Term IRI Term label Parent term IRI Parent term label Alternative term Definition http://purl.obolibrary.org/obo/APO_0000002 abnormal http://purl.obolibrary.org/obo/APO_0000001 qualifier The observed phenotype is detectably different from that in the wild type. http://purl.obolibrary.org/obo/APO_0000003 decreased http://purl.obolibrary.org/obo/APO_0000002 abnormal The observed feature is decreased compared to that in the wild type (slower, weaker, lower, smaller, etc.). http://purl.obolibrary.org/obo/APO_0000004 increased http://purl.obolibrary.org/obo/APO_0000002 abnormal The observed feature is increased compared to that in the wild type (faster, stronger, higher, larger, etc.). http://purl.obolibrary.org/obo/APO_0000005 absent http://purl.obolibrary.org/obo/APO_0000003 decreased The observed feature is not detectable in the mutant. http://purl.obolibrary.org/obo/APO_0000007 misexpression http://purl.obolibrary.org/obo/APO_0000006 mutant_type The mutation results in expression of the gene product at a developmental stage, in a cell type, or at a subcellular location different from that at which the wild-type gene is expressed. http://purl.obolibrary.org/obo/APO_0000008 overexpression http://purl.obolibrary.org/obo/APO_0000006 mutant_type The mutation causes expression of the otherwise normal gene product to higher levels than wild-type. http://purl.obolibrary.org/obo/APO_0000009 activation http://purl.obolibrary.org/obo/APO_0000006 mutant_type The mutation increases the normal activity of a gene product. http://purl.obolibrary.org/obo/APO_0000010 gain of function http://purl.obolibrary.org/obo/APO_0000006 mutant_type The mutation confers a new activity on the gene product. http://purl.obolibrary.org/obo/APO_0000011 null mutant http://purl.obolibrary.org/obo/APO_0000006 mutant_type The mutation abolishes completely the function of the gene product. http://purl.obolibrary.org/obo/APO_0000012 repressible http://purl.obolibrary.org/obo/APO_0000006 mutant_type The mutation leads to reduction of levels of the gene product, often through the use of a repressible promoter. http://purl.obolibrary.org/obo/APO_0000013 reduction of function http://purl.obolibrary.org/obo/APO_0000006 mutant_type The mutation reduces the activity of the gene product. http://purl.obolibrary.org/obo/APO_0000014 conditional http://purl.obolibrary.org/obo/APO_0000006 mutant_type The activity of the gene product is normal under some conditions and altered under others. http://purl.obolibrary.org/obo/APO_0000015 unspecified http://purl.obolibrary.org/obo/APO_0000006 mutant_type The mutation type is not specified in the reference. http://purl.obolibrary.org/obo/APO_0000020 classical genetics http://purl.obolibrary.org/obo/APO_0000192 phenotype assays Phenotypic analysis of one or a few mutant strains in small-scale, focused experiments that do not require knowledge of the entire genome sequence. http://purl.obolibrary.org/obo/APO_0000021 competitive growth http://purl.obolibrary.org/obo/APO_0000114 large-scale survey Quantitative data on survival of a mutant strain, obtained in large scale experiments where mutants are grown together with wild type or other mutants for many generations. http://purl.obolibrary.org/obo/APO_0000022 protein activity http://purl.obolibrary.org/obo/APO_0000094 metabolism and growth The enzymatic or other activity of a protein. http://purl.obolibrary.org/obo/APO_0000023 development http://purl.obolibrary.org/obo/APO_0000017 observable Developmental processes. http://purl.obolibrary.org/obo/APO_0000024 budding http://purl.obolibrary.org/obo/APO_0000023 development The formation of a bud, which develops into a daughter cell during asexual reproduction. http://purl.obolibrary.org/obo/APO_0000025 axial budding pattern http://purl.obolibrary.org/obo/APO_0000200 budding pattern Localization of the newly emerging bud near the site of the previous bud. http://purl.obolibrary.org/obo/APO_0000026 bipolar budding pattern http://purl.obolibrary.org/obo/APO_0000200 budding pattern Localization of the emerging bud at the cell pole opposite the previous bud site. http://purl.obolibrary.org/obo/APO_0000027 filamentous growth http://purl.obolibrary.org/obo/APO_0000023 development Growth in a threadlike, filamentous shape. http://purl.obolibrary.org/obo/APO_0000028 invasive growth http://purl.obolibrary.org/obo/APO_0000027 filamentous growth Penetration of cells into a solid substrate during filamentous growth. http://purl.obolibrary.org/obo/APO_0000029 pseudohyphal growth http://purl.obolibrary.org/obo/APO_0000027 filamentous growth Growth in a pattern that occurs in conditions of nitrogen limitation and abundant fermentable carbon source. Cells become elongated, switch to a unipolar budding pattern, remain physically attached to each other, and invade the growth substrate. http://purl.obolibrary.org/obo/APO_0000030 lifespan http://purl.obolibrary.org/obo/APO_0000023 development The duration of the life of an individual organism. http://purl.obolibrary.org/obo/APO_0000031 sexual cycle http://purl.obolibrary.org/obo/APO_0000023 development The process of sexual reproduction. http://purl.obolibrary.org/obo/APO_0000032 mating response http://purl.obolibrary.org/obo/APO_0000031 sexual cycle The interaction between organisms leading to mating. http://purl.obolibrary.org/obo/APO_0000033 cell fusion http://purl.obolibrary.org/obo/APO_0000032 mating response The fusion of individual cells from each partner during mating. http://purl.obolibrary.org/obo/APO_0000034 mating efficiency http://purl.obolibrary.org/obo/APO_0000032 mating response The proportion of cells within a population that are able to mate. http://purl.obolibrary.org/obo/APO_0000035 nuclear fusion during mating http://purl.obolibrary.org/obo/APO_0000032 mating response The fusion of the nuclei of two mating cells. http://purl.obolibrary.org/obo/APO_0000036 pheromone production http://purl.obolibrary.org/obo/APO_0000032 mating response The production of mating pheromones. http://purl.obolibrary.org/obo/APO_0000037 pheromone sensitivity http://purl.obolibrary.org/obo/APO_0000032 mating response Sensitivity to mating pheromones produced by cells of the opposite mating type. http://purl.obolibrary.org/obo/APO_0000038 shmoo formation http://purl.obolibrary.org/obo/APO_0000032 mating response An alteration of morphology such that the cell has a mating projection, formed in response to mating pheromone by cells of Saccharomyces and other fungi with similar life cycles. Named after the Al Capp cartoon character, whose shape it resembles. http://purl.obolibrary.org/obo/APO_0000039 meiosis http://purl.obolibrary.org/obo/APO_0000031 sexual cycle A specialized cell division in which a single diploid cell undergoes two nuclear divisions following a single round of DNA replication in order to produce four daughter cells that contain half the number of chromosomes as the diploid cell. http://purl.obolibrary.org/obo/APO_0000040 meiotic recombination http://purl.obolibrary.org/obo/APO_0000039 meiosis The exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes during meiosis. http://purl.obolibrary.org/obo/APO_0000041 sporulation http://purl.obolibrary.org/obo/APO_0000031 sexual cycle The formation of ascospores, which are the products of meiosis. http://purl.obolibrary.org/obo/APO_0000042 spore germination http://purl.obolibrary.org/obo/APO_0000041 sporulation The production of viable cells arising from sexual spores. http://purl.obolibrary.org/obo/APO_0000043 spore wall formation http://purl.obolibrary.org/obo/APO_0000041 sporulation The biogenesis of specialized cell walls around developing ascospores. http://purl.obolibrary.org/obo/APO_0000044 sporulation efficiency http://purl.obolibrary.org/obo/APO_0000041 sporulation The percentage of diploid cells in a population that undergo meiosis and form spores under sporulation-inducing conditions. http://purl.obolibrary.org/obo/APO_0000045 sterile http://purl.obolibrary.org/obo/APO_0000031 sexual cycle The sterile phenotype is the inability to mate with cells of the opposite mating type under conditions that normally promote mating. http://purl.obolibrary.org/obo/APO_0000046 silencing http://purl.obolibrary.org/obo/APO_0000143 chromosome/plasmid maintenance Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin. http://purl.obolibrary.org/obo/APO_0000047 transposable element transposition http://purl.obolibrary.org/obo/APO_0000143 chromosome/plasmid maintenance Integration of a transposable element into new positions in the genome. http://purl.obolibrary.org/obo/APO_0000048 virulence http://purl.obolibrary.org/obo/APO_0000287 interaction with host/environment The ability to cause disease in another organism. http://purl.obolibrary.org/obo/APO_0000049 morphology http://purl.obolibrary.org/obo/APO_0000017 observable The size or shape of subcellular structures, cells, or multicellular structures. http://purl.obolibrary.org/obo/APO_0000050 cellular morphology http://purl.obolibrary.org/obo/APO_0000049 morphology The size or shape of cells. http://purl.obolibrary.org/obo/APO_0000051 cell shape http://purl.obolibrary.org/obo/APO_0000050 cellular morphology The shape of the cell. http://purl.obolibrary.org/obo/APO_0000052 cell size http://purl.obolibrary.org/obo/APO_0000050 cellular morphology The size of the cell. http://purl.obolibrary.org/obo/APO_0000053 cell wall morphology http://purl.obolibrary.org/obo/APO_0000226 subcellular morphology The size, shape, or appearance of the cell wall. http://purl.obolibrary.org/obo/APO_0000054 cytoskeleton morphology http://purl.obolibrary.org/obo/APO_0000226 subcellular morphology The size, shape, or appearance of the cytoskeleton. http://purl.obolibrary.org/obo/APO_0000055 mitochondrial morphology http://purl.obolibrary.org/obo/APO_0000226 subcellular morphology The size, shape, or appearance of the mitochondria. http://purl.obolibrary.org/obo/APO_0000056 bud neck morphology http://purl.obolibrary.org/obo/APO_0000050 cellular morphology The size or shape of the bud neck, which is the region where the bud joins the mother cell. http://purl.obolibrary.org/obo/APO_0000057 nuclear morphology http://purl.obolibrary.org/obo/APO_0000303 endomembrane system morphology The size, shape, or appearance of the nucleus. http://purl.obolibrary.org/obo/APO_0000058 peroxisomal morphology http://purl.obolibrary.org/obo/APO_0000303 endomembrane system morphology The size, shape, or appearance of the peroxisomes. http://purl.obolibrary.org/obo/APO_0000059 vacuolar morphology http://purl.obolibrary.org/obo/APO_0000303 endomembrane system morphology The size, shape, or appearance of the vacuole. http://purl.obolibrary.org/obo/APO_0000060 colony appearance http://purl.obolibrary.org/obo/APO_0000158 culture appearance The appearance of colonies of cells growing on a solid substrate. http://purl.obolibrary.org/obo/APO_0000061 colony color http://purl.obolibrary.org/obo/APO_0000060 colony appearance The color of colonies of cells growing on a solid substrate. http://purl.obolibrary.org/obo/APO_0000062 colony shape http://purl.obolibrary.org/obo/APO_0000060 colony appearance The shape of colonies of cells growing on a solid substrate. http://purl.obolibrary.org/obo/APO_0000063 colony size http://purl.obolibrary.org/obo/APO_0000060 colony appearance The size of colonies of cells growing on a solid substrate. http://purl.obolibrary.org/obo/APO_0000064 liquid culture appearance http://purl.obolibrary.org/obo/APO_0000158 culture appearance The appearance of a liquid culture of cells. http://purl.obolibrary.org/obo/APO_0000065 flocculation http://purl.obolibrary.org/obo/APO_0000064 liquid culture appearance Adhesion and aggregation of cells in liquid culture to produce clumps of cells. http://purl.obolibrary.org/obo/APO_0000066 cellular processes http://purl.obolibrary.org/obo/APO_0000017 observable Processes occurring at the cellular level. http://purl.obolibrary.org/obo/APO_0000071 cytokinesis http://purl.obolibrary.org/obo/APO_0000072 mitotic cell cycle The division of the cytoplasm and the plasma membrane of a cell and its separation into two daughter cells. http://purl.obolibrary.org/obo/APO_0000072 mitotic cell cycle http://purl.obolibrary.org/obo/APO_0000066 cellular processes A cycle of DNA replication and cell division via mitosis. http://purl.obolibrary.org/obo/APO_0000073 intracellular transport http://purl.obolibrary.org/obo/APO_0000066 cellular processes Transport of substances within cells. http://purl.obolibrary.org/obo/APO_0000074 autophagy http://purl.obolibrary.org/obo/APO_0000073 intracellular transport The delivery and degradation of autophagy markers to the vacuole via the autophagic pathway. http://purl.obolibrary.org/obo/APO_0000075 endocytosis http://purl.obolibrary.org/obo/APO_0000073 intracellular transport The uptake and delivery of external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. http://purl.obolibrary.org/obo/APO_0000076 mitochondrial transport http://purl.obolibrary.org/obo/APO_0000129 protein transport Import of proteins into mitochondria. http://purl.obolibrary.org/obo/APO_0000077 nuclear transport http://purl.obolibrary.org/obo/APO_0000129 protein transport Transport of proteins or RNAs into or out of the nucleus. http://purl.obolibrary.org/obo/APO_0000078 protein secretion http://purl.obolibrary.org/obo/APO_0000129 protein transport Transport of proteins out of the cell by fusion of a membrane-bounded vesicle containing the proteins by fusion of the vesicle with the plasma membrane. http://purl.obolibrary.org/obo/APO_0000079 vacuolar transport http://purl.obolibrary.org/obo/APO_0000129 protein transport Transport of proteins into the vacuole. http://purl.obolibrary.org/obo/APO_0000080 stress resistance http://purl.obolibrary.org/obo/APO_0000066 cellular processes The level of resistance to stress conditions. http://purl.obolibrary.org/obo/APO_0000081 killer toxin resistance http://purl.obolibrary.org/obo/APO_0000215 toxin resistance The level of resistance to killer toxin, which is encoded on double-stranded RNA viruses carried by some yeast strains. http://purl.obolibrary.org/obo/APO_0000082 osmotic stress resistance http://purl.obolibrary.org/obo/APO_0000087 resistance to chemicals The level of resistance to high or low osmolarity. http://purl.obolibrary.org/obo/APO_0000083 oxidative stress resistance http://purl.obolibrary.org/obo/APO_0000087 resistance to chemicals The level of resistance to oxidative stress. http://purl.obolibrary.org/obo/APO_0000084 radiation resistance http://purl.obolibrary.org/obo/APO_0000080 stress resistance The level of resistance to radiation. http://purl.obolibrary.org/obo/APO_0000085 UV resistance http://purl.obolibrary.org/obo/APO_0000084 radiation resistance The level of resistance to ultraviolet radiation. http://purl.obolibrary.org/obo/APO_0000086 X ray resistance http://purl.obolibrary.org/obo/APO_0000194 ionizing radiation resistance The level of resistance to X ray exposure. http://purl.obolibrary.org/obo/APO_0000087 resistance to chemicals http://purl.obolibrary.org/obo/APO_0000080 stress resistance The level of resistance to exposure to chemicals. http://purl.obolibrary.org/obo/APO_0000089 budding index http://purl.obolibrary.org/obo/APO_0000024 budding The percentage or fraction of budded cells in a population. http://purl.obolibrary.org/obo/APO_0000090 metal resistance http://purl.obolibrary.org/obo/APO_0000087 resistance to chemicals The level of resistance to a specific metal or metals. http://purl.obolibrary.org/obo/APO_0000091 starvation resistance http://purl.obolibrary.org/obo/APO_0000080 stress resistance The level of resistance to starvation conditions. http://purl.obolibrary.org/obo/APO_0000092 temperature sensitive growth http://purl.obolibrary.org/obo/APO_0000080 stress resistance Sensitivity to temperatures that are higher or lower than optimal growth temperature. http://purl.obolibrary.org/obo/APO_0000093 thermotolerance http://purl.obolibrary.org/obo/APO_0000080 stress resistance The ability to survive a period of exposure to extremely high temperature (heat shock). http://purl.obolibrary.org/obo/APO_0000094 metabolism and growth http://purl.obolibrary.org/obo/APO_0000017 observable Processes relating to metabolism and growth. http://purl.obolibrary.org/obo/APO_0000095 chemical compound accumulation http://purl.obolibrary.org/obo/APO_0000094 metabolism and growth The production and/or storage of a specified chemical compound. http://purl.obolibrary.org/obo/APO_0000096 nutrient utilization http://purl.obolibrary.org/obo/APO_0000094 metabolism and growth The ability to utilize specified substances as nutrients. http://purl.obolibrary.org/obo/APO_0000097 auxotrophy http://purl.obolibrary.org/obo/APO_0000096 nutrient utilization The inability of an organism to synthesize a specified organic compound required for its growth. http://purl.obolibrary.org/obo/APO_0000098 utilization of carbon source http://purl.obolibrary.org/obo/APO_0000096 nutrient utilization The ability to utilize the specified compound as a carbon source. http://purl.obolibrary.org/obo/APO_0000099 utilization of nitrogen source http://purl.obolibrary.org/obo/APO_0000096 nutrient utilization The ability to utilize the specified compound as a source of nitrogen. http://purl.obolibrary.org/obo/APO_0000100 nutrient uptake http://purl.obolibrary.org/obo/APO_0000096 nutrient utilization Uptake of nutrients into a cell. http://purl.obolibrary.org/obo/APO_0000101 fermentative metabolism http://purl.obolibrary.org/obo/APO_0000098 utilization of carbon source Growth with energy derived from fermentation; growth on a fermentable carbon source such as glucose. http://purl.obolibrary.org/obo/APO_0000102 respiratory metabolism http://purl.obolibrary.org/obo/APO_0000098 utilization of carbon source Growth with energy derived from respiration; growth on a non-fermentable carbon source. Examples of non-fermentable carbon sources include glycerol, ethanol, and lactate. http://purl.obolibrary.org/obo/APO_0000104 mitochondrial rho- mutation frequency http://purl.obolibrary.org/obo/APO_0000105 mitochondrial genome maintenance The frequency with rho- (rho minus) mutations occur, In this process, all of the mitochondrial genome except for a relatively short segment is lost. The retained segment is amplified and reiterated in a circular genome that is roughly the size of the wild-type genome. http://purl.obolibrary.org/obo/APO_0000105 mitochondrial genome maintenance http://purl.obolibrary.org/obo/APO_0000102 respiratory metabolism The maintenance of a stable and complete mitochondrial genome. http://purl.obolibrary.org/obo/APO_0000106 vegetative growth http://purl.obolibrary.org/obo/APO_0000094 metabolism and growth Growth under standard culture conditions (liquid or solid media). http://purl.obolibrary.org/obo/APO_0000109 survival rate in stationary phase http://purl.obolibrary.org/obo/APO_0000106 vegetative growth The rate of survival in liquid stationary phase cultures. http://purl.obolibrary.org/obo/APO_0000110 competitive fitness http://purl.obolibrary.org/obo/APO_0000216 fitness The ability of a mutant strain to grow or survive under conditions of direct competition with wild type or other mutants. http://purl.obolibrary.org/obo/APO_0000111 viability http://purl.obolibrary.org/obo/APO_0000216 fitness The proportion of cells in a sample that are viable, i.e. able to form colonies. Often measured by spotting aliquots of a dilution series on a plate. http://purl.obolibrary.org/obo/APO_0000112 inviable http://purl.obolibrary.org/obo/APO_0000217 essentiality The inability to grow under standard growth conditions. For S. cerevisiae, this means that visible colonies are not formed from single cells on complete glucose medium (YPD) plates at 30 deg C under normal atmospheric conditions. http://purl.obolibrary.org/obo/APO_0000113 viable http://purl.obolibrary.org/obo/APO_0000217 essentiality The ability to grow under standard growth conditions. For S. cerevisiae, this means that visible colonies are formed from single cells on complete glucose medium (YPD) plates at 30 deg C under normal atmospheric conditions. http://purl.obolibrary.org/obo/APO_0000114 large-scale survey http://purl.obolibrary.org/obo/APO_0000192 phenotype assays Generation and analysis of genome-wide sets of mutants that typically utilizes robotic methods. http://purl.obolibrary.org/obo/APO_0000117 normal http://purl.obolibrary.org/obo/APO_0000001 qualifier The observed phenotype shows no detectable difference between the mutant and the wild type. http://purl.obolibrary.org/obo/APO_0000118 nuclear position http://purl.obolibrary.org/obo/APO_0000296 organelle distribution The location of the nucleus or nuclei within a cell or between separating cells. http://purl.obolibrary.org/obo/APO_0000119 size of nucleus http://purl.obolibrary.org/obo/APO_0000057 nuclear morphology The size of the nucleus. http://purl.obolibrary.org/obo/APO_0000120 actin cytoskeleton morphology http://purl.obolibrary.org/obo/APO_0000054 cytoskeleton morphology The size, shape, or appearance of the actin cytoskeleton. http://purl.obolibrary.org/obo/APO_0000123 recovery from pheromone-induced cell cycle arrest http://purl.obolibrary.org/obo/APO_0000037 pheromone sensitivity Resumption of the cell cycle after the arrest that occurs in response to the presence of mating pheromones from cells of the opposite mating type. http://purl.obolibrary.org/obo/APO_0000124 pheromone-induced cell cycle arrest http://purl.obolibrary.org/obo/APO_0000037 pheromone sensitivity Arrest of the cell cycle that occurs in response to the presence of mating pheromones from cells of the opposite mating type. http://purl.obolibrary.org/obo/APO_0000125 utilization of phosphorus source http://purl.obolibrary.org/obo/APO_0000096 nutrient utilization The ability to utilize the specified compound as a source of phosphorus. http://purl.obolibrary.org/obo/APO_0000126 nuclear import http://purl.obolibrary.org/obo/APO_0000077 nuclear transport Transport of proteins or RNAs into or out of the nucleus. http://purl.obolibrary.org/obo/APO_0000127 nuclear export http://purl.obolibrary.org/obo/APO_0000077 nuclear transport Export of proteins or RNAs from the nucleus. http://purl.obolibrary.org/obo/APO_0000128 peroxisomal transport http://purl.obolibrary.org/obo/APO_0000129 protein transport Import of proteins into peroxisomes. http://purl.obolibrary.org/obo/APO_0000129 protein transport http://purl.obolibrary.org/obo/APO_0000073 intracellular transport Delivery of proteins to specific locations. http://purl.obolibrary.org/obo/APO_0000130 small molecule transport http://purl.obolibrary.org/obo/APO_0000073 intracellular transport Transport of small molecules into, out of, or within the cell. http://purl.obolibrary.org/obo/APO_0000131 protein/peptide modification http://purl.obolibrary.org/obo/APO_0000094 metabolism and growth The covalent modification of a specified protein. http://purl.obolibrary.org/obo/APO_0000132 RNA localization http://purl.obolibrary.org/obo/APO_0000073 intracellular transport Localization of specific RNAs within the cell. http://purl.obolibrary.org/obo/APO_0000141 critical cell size at START (G1 cell-size checkpoint) http://purl.obolibrary.org/obo/APO_0000052 cell size The cell volume (or size) which must be attained before cells can pass through START, a checkpoint which operates in G1, and commit to a full round of cell division. http://purl.obolibrary.org/obo/APO_0000142 critical cell size at G2/M (cryptic G2/M cell size checkpoint) http://purl.obolibrary.org/obo/APO_0000052 cell size The cell volume (or size) which must be attained before cells can pass from G2 into M phase and commit to the completion of mitosis. This normally cryptic checkpoint negatively regulates passage from G2 into M phase. http://purl.obolibrary.org/obo/APO_0000143 chromosome/plasmid maintenance http://purl.obolibrary.org/obo/APO_0000066 cellular processes The stable maintenance of chromosomes or plasmids. http://purl.obolibrary.org/obo/APO_0000144 telomere length http://purl.obolibrary.org/obo/APO_0000143 chromosome/plasmid maintenance The average length of telomeres. http://purl.obolibrary.org/obo/APO_0000145 oxidative phosphorylation http://purl.obolibrary.org/obo/APO_0000102 respiratory metabolism The oxidation of nutrients to generate ATP, performed by enzymes of the mitochondrial inner membrane. http://purl.obolibrary.org/obo/APO_0000147 heat sensitivity http://purl.obolibrary.org/obo/APO_0000092 temperature sensitive growth Sensitivity to temperatures that are higher than optimal growth temperature. http://purl.obolibrary.org/obo/APO_0000148 cold sensitivity http://purl.obolibrary.org/obo/APO_0000092 temperature sensitive growth Sensitivity to temperatures that are lower than optimal growth temperature. http://purl.obolibrary.org/obo/APO_0000149 protein/peptide accumulation http://purl.obolibrary.org/obo/APO_0000094 metabolism and growth Abundance of a specified peptide/protein; production to a certain level. http://purl.obolibrary.org/obo/APO_0000152 haploinsufficient http://purl.obolibrary.org/obo/APO_0000216 fitness The heterozygous diploid displays a decreased growth rate relative to a diploid that is homozygous wild type at that locus. http://purl.obolibrary.org/obo/APO_0000153 petite http://purl.obolibrary.org/obo/APO_0000102 respiratory metabolism The formation of smaller than wild-type colonies on fermentable carbon sources (e.g., glucose), due to a respiratory defect. The respiratory defect could result from mutation or loss of the mitochondrial genome, or from a nuclear mutation affecting respiration. The fermentation of glucose produces ethanol, which is metabolized by the respiratory pathway in wild-type cells and contributes to colony size; respiratory-deficient mutants are unable to utilize this ethanol. http://purl.obolibrary.org/obo/APO_0000154 petite-negative http://purl.obolibrary.org/obo/APO_0000102 respiratory metabolism The petite-negative phenotype arises from mutation in a nuclear gene that is not essential in an otherwise wild-type strain with an intact mitochondrial genome, but becomes essential in strains lacking the mitochondrial genome, referred to as rho- or rho0. Petite-negative strains cannot grow on fermentable carbon sources (e.g., glucose) in the absence of an intact mitochondrial genome. This phenotype is often assayed as the inability grow in the presence of ethidium bromide, which causes the loss of the mitochondrial genome. http://purl.obolibrary.org/obo/APO_0000155 apoptosis http://purl.obolibrary.org/obo/APO_0000312 cell death An energy-dependent, programmed form of cell death that is characterized by phenotypic markers such as increased levels of reactive oxygen species (often detected via DHE staining), externalization of phosphatidylserine (measured by annexin V staining), and DNA fragmentation (detected using the TUNEL assay). Other processes observed during apoptosis include chromosome condensation and breakdown of mitochondria, including loss of membrane potential and release of cytochrome c. Cells undergoing apoptosis do not lose plasma membrane integrity (measured by propidium iodide staining) until late in the process. http://purl.obolibrary.org/obo/APO_0000157 utilization of iron source http://purl.obolibrary.org/obo/APO_0000096 nutrient utilization The ability to utilize the specified compound as a source of iron. http://purl.obolibrary.org/obo/APO_0000158 culture appearance http://purl.obolibrary.org/obo/APO_0000049 morphology The appearance of a population of cells. http://purl.obolibrary.org/obo/APO_0000159 biofilm formation http://purl.obolibrary.org/obo/APO_0000158 culture appearance The ability to form a layer on solid surfaces with or without other microorganisms. http://purl.obolibrary.org/obo/APO_0000193 resistance to enzymatic treatment http://purl.obolibrary.org/obo/APO_0000080 stress resistance The level of resistance to treatment with enzymes. http://purl.obolibrary.org/obo/APO_0000194 ionizing radiation resistance http://purl.obolibrary.org/obo/APO_0000084 radiation resistance The level of resistance to ionizing radiation. http://purl.obolibrary.org/obo/APO_0000195 gamma ray resistance http://purl.obolibrary.org/obo/APO_0000194 ionizing radiation resistance The level of resistance to gamma radiation. http://purl.obolibrary.org/obo/APO_0000196 mating type switching http://purl.obolibrary.org/obo/APO_0000031 sexual cycle Conversion of a cell of one mating type to a different mating type. http://purl.obolibrary.org/obo/APO_0000197 colony sectoring http://purl.obolibrary.org/obo/APO_0000060 colony appearance Formation of wedge-shaped sectors, with a different color or appearance, in colonies of cells growing on a solid substrate. http://purl.obolibrary.org/obo/APO_0000198 mutation frequency http://purl.obolibrary.org/obo/APO_0000143 chromosome/plasmid maintenance The frequency with which mutations occur. http://purl.obolibrary.org/obo/APO_0000199 chitin deposition http://purl.obolibrary.org/obo/APO_0000053 cell wall morphology The pattern of chitin deposition in the cell wall. http://purl.obolibrary.org/obo/APO_0000200 budding pattern http://purl.obolibrary.org/obo/APO_0000024 budding The pattern with which buds emerge from a mother cell. http://purl.obolibrary.org/obo/APO_0000201 acid pH resistance http://purl.obolibrary.org/obo/APO_0000087 resistance to chemicals The level of resistance to acidic pH. http://purl.obolibrary.org/obo/APO_0000202 alkaline pH resistance http://purl.obolibrary.org/obo/APO_0000087 resistance to chemicals The level of resistance to alkaline pH. http://purl.obolibrary.org/obo/APO_0000203 hypoosmotic stress resistance http://purl.obolibrary.org/obo/APO_0000082 osmotic stress resistance The level of resistance to low osmolarity. http://purl.obolibrary.org/obo/APO_0000204 hyperosmotic stress resistance http://purl.obolibrary.org/obo/APO_0000082 osmotic stress resistance The level of resistance to high osmolarity. http://purl.obolibrary.org/obo/APO_0000205 ionic stress resistance http://purl.obolibrary.org/obo/APO_0000087 resistance to chemicals The level of resistance to ionic stress. http://purl.obolibrary.org/obo/APO_0000208 chromosome segregation http://purl.obolibrary.org/obo/APO_0000143 chromosome/plasmid maintenance The physical separation of chromosomes and their distribution to two or more sets during mitosis or meiosis. http://purl.obolibrary.org/obo/APO_0000209 protein/peptide distribution http://purl.obolibrary.org/obo/APO_0000094 metabolism and growth The location(s) where the specified protein is found within the cell. http://purl.obolibrary.org/obo/APO_0000210 anaerobic metabolism http://purl.obolibrary.org/obo/APO_0000094 metabolism and growth Metabolism during growth in the absence of oxygen. http://purl.obolibrary.org/obo/APO_0000212 bud morphology http://purl.obolibrary.org/obo/APO_0000050 cellular morphology The size or shape of the bud. http://purl.obolibrary.org/obo/APO_0000213 spindle morphology http://purl.obolibrary.org/obo/APO_0000054 cytoskeleton morphology The size, shape, or appearance of the mitotic or meiotic spindle. http://purl.obolibrary.org/obo/APO_0000214 position of spindle pole body http://purl.obolibrary.org/obo/APO_0000213 spindle morphology The position of the mitotic or meiotic spindle pole body. http://purl.obolibrary.org/obo/APO_0000215 toxin resistance http://purl.obolibrary.org/obo/APO_0000080 stress resistance The level of resistance to toxins, poisonous compounds that are produced by cells or organisms. http://purl.obolibrary.org/obo/APO_0000216 fitness http://purl.obolibrary.org/obo/APO_0000017 observable The ability of an organism to reproduce and to produce viable progeny. http://purl.obolibrary.org/obo/APO_0000217 essentiality http://purl.obolibrary.org/obo/APO_0000017 observable The essentiality of a gene for survival under standard conditions for growth of that organism. http://purl.obolibrary.org/obo/APO_0000218 redox state http://purl.obolibrary.org/obo/APO_0000094 metabolism and growth The balance of oxidized and reduced molecules in the cell. Respiration and various environmental factors cause formation of reactive oxygen species which can oxidize and damage cellular components. http://purl.obolibrary.org/obo/APO_0000219 utilization of sulfur source http://purl.obolibrary.org/obo/APO_0000096 nutrient utilization The ability to utilize the specified compound as a source of sulfur. http://purl.obolibrary.org/obo/APO_0000220 necrotic cell death http://purl.obolibrary.org/obo/APO_0000312 cell death A form of cell death that is distinct from apoptosis. Cells undergoing necrotic cell death undergo overall destruction. They can be distinguished from apoptotic cells because they lose membrane integrity, which only happens late in apoptosis (positive propidium iodide staining), and do not externalize phosphatidylserine (measured by annexin V staining) as do apoptotic cells. http://purl.obolibrary.org/obo/APO_0000221 septum formation http://purl.obolibrary.org/obo/APO_0000053 cell wall morphology Formation of a septum between dividing cells. http://purl.obolibrary.org/obo/APO_0000222 chemical compound excretion http://purl.obolibrary.org/obo/APO_0000094 metabolism and growth The excretion from the cell of a specified chemical compound. http://purl.obolibrary.org/obo/APO_0000223 mating projection morphology http://purl.obolibrary.org/obo/APO_0000050 cellular morphology The outward appearance or shape of the mating projection. http://purl.obolibrary.org/obo/APO_0000224 RNA accumulation http://purl.obolibrary.org/obo/APO_0000094 metabolism and growth Abundance of a specified RNA or class of RNAs. http://purl.obolibrary.org/obo/APO_0000225 mitotic recombination http://purl.obolibrary.org/obo/APO_0000143 chromosome/plasmid maintenance Measures of the rate of recombination or total recombination observed during the mitotic cell cycle. http://purl.obolibrary.org/obo/APO_0000226 subcellular morphology http://purl.obolibrary.org/obo/APO_0000050 cellular morphology The size, shape, or appearance of subcellular organelles or structures. http://purl.obolibrary.org/obo/APO_0000228 dominant negative http://purl.obolibrary.org/obo/APO_0000006 mutant_type The mutation results in a gene product that interferes with the function of the normal, wild-type gene product. http://purl.obolibrary.org/obo/APO_0000229 homozygous diploid http://purl.obolibrary.org/obo/APO_0000020 classical genetics Classical genetics experiments carried out in a diploid background, where both alleles of the gene being described are identical. http://purl.obolibrary.org/obo/APO_0000230 heterozygous diploid http://purl.obolibrary.org/obo/APO_0000020 classical genetics Classical genetics experiments carried out in a diploid background, where alleles of the gene being described are not identical. http://purl.obolibrary.org/obo/APO_0000231 homozygous diploid, large-scale survey http://purl.obolibrary.org/obo/APO_0000114 large-scale survey Any large-scale survey where the experiments are carried out in a homozygous diploid background. http://purl.obolibrary.org/obo/APO_0000232 heterozygous diploid, large-scale survey http://purl.obolibrary.org/obo/APO_0000114 large-scale survey Any large-scale survey where the experiments carried our are in a heterozygous diploid background. http://purl.obolibrary.org/obo/APO_0000233 homozygous diploid, competitive growth http://purl.obolibrary.org/obo/APO_0000021 competitive growth Any competitive growth experiment carried out in a homozygous diploid background. http://purl.obolibrary.org/obo/APO_0000234 heterozygous diploid, competitive growth http://purl.obolibrary.org/obo/APO_0000021 competitive growth Any competitive growth experiment carried out in a heterozygous diploid background. http://purl.obolibrary.org/obo/APO_0000235 systematic mutation set http://purl.obolibrary.org/obo/APO_0000114 large-scale survey Robotic generation and analysis of large-scale, genome-wide haploid knockout sets. http://purl.obolibrary.org/obo/APO_0000236 homozygous diploid, systematic mutation set http://purl.obolibrary.org/obo/APO_0000235 systematic mutation set Robotic generation and analysis of large-scale, genome-wide knockout sets carried out in a homozygous diploid background. http://purl.obolibrary.org/obo/APO_0000237 heterozygous diploid, systematic mutation set http://purl.obolibrary.org/obo/APO_0000235 systematic mutation set Robotic generation and analysis of large-scale, genome-wide mutation sets carried out in a heterozygous diploid. http://purl.obolibrary.org/obo/APO_0000239 pexophagy http://purl.obolibrary.org/obo/APO_0000074 autophagy A form of autophagy selective for peroxisomes that occurs in response to starvation, damage or as a homeostatic mechanism to regulate the levels of this organelle. Pexophagy can be further subdivided into micropexophagy, the engulfment of a cluster of peroxisomes at the vacuole surface and macropexophagy, the sequestration of individual peroxisomes by a double-membrane vesicle, followed by fusion with the vacuole. http://purl.obolibrary.org/obo/APO_0000240 mitophagy http://purl.obolibrary.org/obo/APO_0000074 autophagy A form of autophagy selective for mitochondria that occurs in response to starvation, damage or during a shift in environmental conditions. The process can be further subdivided into micromitophagy, the engulfment of a cluster of mitochondria at the vacuole surface, and macromitophagy, the sequestration of individual mitochondria by a double-membrane vesicle, followed by fusion with the vacuole. http://purl.obolibrary.org/obo/APO_0000241 freeze-thaw resistance http://purl.obolibrary.org/obo/APO_0000080 stress resistance The level of resistance to one or more cycles of freezing and thawing. http://purl.obolibrary.org/obo/APO_0000242 lipid particle morphology http://purl.obolibrary.org/obo/APO_0000226 subcellular morphology The size, shape, or appearance of lipid particles or droplets, subcellular structures consisting of a hydrophobic core of neutral lipids (triacylglycerol and steryl esters), surrounded by a phospholipid monolayer with a small quantity of embedded proteins including enzymes involved in lipid biosynthesis. Lipid particles function as a storage compartment for lipid components. http://purl.obolibrary.org/obo/APO_0000243 Golgi morphology http://purl.obolibrary.org/obo/APO_0000303 endomembrane system morphology The size, shape or appearance of the Golgi apparatus or its parts. http://purl.obolibrary.org/obo/APO_0000245 decreased rate http://purl.obolibrary.org/obo/APO_0000002 abnormal Observed feature is decreased with respect to time compared to that in the wild type (slower). http://purl.obolibrary.org/obo/APO_0000246 increased rate http://purl.obolibrary.org/obo/APO_0000002 abnormal Observed feature is increased with respect to time compared to that in the wild type (faster, accelerated). http://purl.obolibrary.org/obo/APO_0000247 decreased duration http://purl.obolibrary.org/obo/APO_0000002 abnormal Observed feature occurs over a decreased period of time relative to wild type. http://purl.obolibrary.org/obo/APO_0000248 increased duration http://purl.obolibrary.org/obo/APO_0000002 abnormal Observed feature occurs over an increased period of time relative to wild type. http://purl.obolibrary.org/obo/APO_0000249 delayed http://purl.obolibrary.org/obo/APO_0000002 abnormal Observed feature occurs after being postponed for a period of time relative to wild type. http://purl.obolibrary.org/obo/APO_0000250 arrested http://purl.obolibrary.org/obo/APO_0000002 abnormal Observed feature does not occur in a given time period relative to wild type. http://purl.obolibrary.org/obo/APO_0000251 premature http://purl.obolibrary.org/obo/APO_0000002 abnormal Observed feature occurs too soon, existing before the proper or usual time compared to wild type. http://purl.obolibrary.org/obo/APO_0000252 normal rate http://purl.obolibrary.org/obo/APO_0000117 normal Observed feature occurs at the same time relative to wild type. http://purl.obolibrary.org/obo/APO_0000253 cell cycle progression http://purl.obolibrary.org/obo/APO_0000072 mitotic cell cycle Progression of cells through the mitotic cell cycle. http://purl.obolibrary.org/obo/APO_0000254 cell cycle progression in G2 phase http://purl.obolibrary.org/obo/APO_0000253 cell cycle progression Progression of cells through the G2 phase or second gap phase of the mitotic cell cycle, the interval between the completion of DNA synthesis and the beginning of mitosis. http://purl.obolibrary.org/obo/APO_0000255 cell cycle progression in G1 phase http://purl.obolibrary.org/obo/APO_0000253 cell cycle progression Progression of cells through the G1 or first gap phase of the mitotic cell cycle, the interval between the completion of mitosis and the beginning of DNA synthesis. http://purl.obolibrary.org/obo/APO_0000256 cell cycle passage through START http://purl.obolibrary.org/obo/APO_0000255 cell cycle progression in G1 phase Passage of cells through cell cycle control point or checkpoint located late in the G1 phase of the mitotic cell cycle just prior to S phase entry; passage through START results in commits cells to progression through the entire cell cycle. http://purl.obolibrary.org/obo/APO_0000257 cell cycle progression through the G2/M phase transition http://purl.obolibrary.org/obo/APO_0000253 cell cycle progression Progression of cells from G2 phase to M phase of the mitotic cell cycle. http://purl.obolibrary.org/obo/APO_0000258 cell cycle progression in M phase http://purl.obolibrary.org/obo/APO_0000253 cell cycle progression Progression of cells through the M phase of the mitotic cell cycle, the phase in which mitosis occurs. http://purl.obolibrary.org/obo/APO_0000259 cell cycle passage through the metaphase-anaphase transition http://purl.obolibrary.org/obo/APO_0000258 cell cycle progression in M phase Progression of cells from metaphase to anaphase during M phase of the mitotic cell cycle. http://purl.obolibrary.org/obo/APO_0000260 cell cycle progression in anaphase http://purl.obolibrary.org/obo/APO_0000258 cell cycle progression in M phase Progression of cells through anaphase during M phase of the mitotic cell cycle. http://purl.obolibrary.org/obo/APO_0000261 cell cycle progression in early anaphase http://purl.obolibrary.org/obo/APO_0000260 cell cycle progression in anaphase Progression of cells through early anaphase during M phase of the mitotic cell cycle. http://purl.obolibrary.org/obo/APO_0000262 cell cycle progression in mid anaphase http://purl.obolibrary.org/obo/APO_0000260 cell cycle progression in anaphase Progression of cells through mid anaphase during M phase of the mitotic cell cycle. http://purl.obolibrary.org/obo/APO_0000263 cell cycle progression in late anaphase http://purl.obolibrary.org/obo/APO_0000260 cell cycle progression in anaphase Progression of cells through late anaphase during M phase of the mitotic cell cycle. http://purl.obolibrary.org/obo/APO_0000264 cell cycle progression in metaphase http://purl.obolibrary.org/obo/APO_0000258 cell cycle progression in M phase Progression of cells through metaphase during M phase of the mitotic cell cycle. http://purl.obolibrary.org/obo/APO_0000265 cell cycle progression in telophase http://purl.obolibrary.org/obo/APO_0000258 cell cycle progression in M phase Progression of cells through telophase, the last of the stages of mitosis during M phase of the mitotic cell cycle. http://purl.obolibrary.org/obo/APO_0000266 cell cycle progression in S phase http://purl.obolibrary.org/obo/APO_0000253 cell cycle progression Progression of cells through S phase, the part of the mitotic cell cycle where DNA synthesis occurs. http://purl.obolibrary.org/obo/APO_0000267 entry into G0 (stationary phase) http://purl.obolibrary.org/obo/APO_0000072 mitotic cell cycle Entry of cells into the G0 or stationary phase of the mitotic cell cycle, where they enter a quiescent state. http://purl.obolibrary.org/obo/APO_0000268 exit from G0 (stationary phase) http://purl.obolibrary.org/obo/APO_0000072 mitotic cell cycle Exit of cells from the G0 or stationary phase of the mitotic cell cycle, where they move from a quiescent state to one where growth and division resumes in the G1 phase of the mitotic cell cycle. http://purl.obolibrary.org/obo/APO_0000269 cell cycle progression through the G1/S phase transition http://purl.obolibrary.org/obo/APO_0000253 cell cycle progression Progression of cells from G1 phase to S phase of the mitotic cell cycle. http://purl.obolibrary.org/obo/APO_0000270 endoplasmic reticulum morphology http://purl.obolibrary.org/obo/APO_0000303 endomembrane system morphology The size, shape, or appearance of the endoplasmic reticulum (ER) or its parts. http://purl.obolibrary.org/obo/APO_0000271 RNA modification http://purl.obolibrary.org/obo/APO_0000094 metabolism and growth Covalent modification of a specified RNA; type of modification specified. http://purl.obolibrary.org/obo/APO_0000273 nucleolar morphology http://purl.obolibrary.org/obo/APO_0000057 nuclear morphology The size, shape, or appearance of the nucleolus or its parts. http://purl.obolibrary.org/obo/APO_0000274 prion state http://purl.obolibrary.org/obo/APO_0000066 cellular processes The presence or absence of prions. http://purl.obolibrary.org/obo/APO_0000275 prion inheritance http://purl.obolibrary.org/obo/APO_0000274 prion state The transmission of prions from a mother cell to a daughter cell during budding. http://purl.obolibrary.org/obo/APO_0000276 prion formation http://purl.obolibrary.org/obo/APO_0000274 prion state The conversion from the state of being prion-free to the state of having prions. http://purl.obolibrary.org/obo/APO_0000277 prion loss http://purl.obolibrary.org/obo/APO_0000274 prion state The conversion from the state of having prions to the state of being prion-free. http://purl.obolibrary.org/obo/APO_0000278 normal duration http://purl.obolibrary.org/obo/APO_0000117 normal Observed feature does not change with respect to time compared to that in the wild type. http://purl.obolibrary.org/obo/APO_0000279 haploid, classical genetics http://purl.obolibrary.org/obo/APO_0000020 classical genetics Any classical genetics experiment carried out in a haploid background. http://purl.obolibrary.org/obo/APO_0000280 haploid, competitive growth http://purl.obolibrary.org/obo/APO_0000021 competitive growth Any competitive growth experiment carried out in a haploid background. http://purl.obolibrary.org/obo/APO_0000281 haploid, large-scale survey http://purl.obolibrary.org/obo/APO_0000114 large-scale survey Any large-scale survey experiment carried out in a haploid background. http://purl.obolibrary.org/obo/APO_0000282 aneuploid, classical genetics http://purl.obolibrary.org/obo/APO_0000020 classical genetics Any classical genetics experiment carried out in an aneuploid background, where the strain carries more or fewer copies than normal of a large chromosomal region, or of one or more entire chromosomes. http://purl.obolibrary.org/obo/APO_0000283 aneuploid, large-scale survey http://purl.obolibrary.org/obo/APO_0000114 large-scale survey Any large-scale survey experiment carried out in an aneuploid background. http://purl.obolibrary.org/obo/APO_0000284 aneuploid, competitive growth http://purl.obolibrary.org/obo/APO_0000021 competitive growth Any competitive growth experiment carried out in an aneuploid background. http://purl.obolibrary.org/obo/APO_0000285 haploid, systematic mutation set http://purl.obolibrary.org/obo/APO_0000235 systematic mutation set Robotic generation and analysis of large-scale, genome-wide knockout sets carried out in a haploid background. http://purl.obolibrary.org/obo/APO_0000286 aneuploid, systematic mutation set http://purl.obolibrary.org/obo/APO_0000235 systematic mutation set Robotic generation and analysis of large-scale, genome-wide knockout sets carried out in an aneuploid background. http://purl.obolibrary.org/obo/APO_0000287 interaction with host/environment http://purl.obolibrary.org/obo/APO_0000017 observable Processes relating to interaction with the environment or with a host organism. http://purl.obolibrary.org/obo/APO_0000288 adhesion http://purl.obolibrary.org/obo/APO_0000287 interaction with host/environment Adherence to a substrate in the environment or in a host. http://purl.obolibrary.org/obo/APO_0000289 response to light http://purl.obolibrary.org/obo/APO_0000287 interaction with host/environment The response to visible light. http://purl.obolibrary.org/obo/APO_0000291 formation of anatomical structure http://purl.obolibrary.org/obo/APO_0000023 development The development of a discrete anatomical structure. http://purl.obolibrary.org/obo/APO_0000292 secondary metabolite production http://purl.obolibrary.org/obo/APO_0000094 metabolism and growth The production of secondary metabolites, which are compounds that are not directly involved in normal growth, development or reproduction. http://purl.obolibrary.org/obo/APO_0000293 utilization of zinc source http://purl.obolibrary.org/obo/APO_0000096 nutrient utilization The ability to utilize the specified compound as a source of zinc. http://purl.obolibrary.org/obo/APO_0000294 utilization of magnesium source http://purl.obolibrary.org/obo/APO_0000096 nutrient utilization The ability to utilize the specified compound as a source of magnesium. http://purl.obolibrary.org/obo/APO_0000295 conidiation http://purl.obolibrary.org/obo/APO_0000023 development The formation of conidia, which are asexual spores. http://purl.obolibrary.org/obo/APO_0000296 organelle distribution http://purl.obolibrary.org/obo/APO_0000073 intracellular transport The localization and placement of a particular organelle. http://purl.obolibrary.org/obo/APO_0000297 mitochondrial distribution http://purl.obolibrary.org/obo/APO_0000296 organelle distribution The localization and placement of mitochondria within a cell or between separating cells. http://purl.obolibrary.org/obo/APO_0000298 peroxisomal distribution http://purl.obolibrary.org/obo/APO_0000296 organelle distribution The localization and placement of peroxisomes within a cell or between separating cells. http://purl.obolibrary.org/obo/APO_0000299 vacuolar distribution http://purl.obolibrary.org/obo/APO_0000296 organelle distribution The localization and placement of vacuoles within a cell or between separating cells. http://purl.obolibrary.org/obo/APO_0000300 endoplasmic reticulum distribution http://purl.obolibrary.org/obo/APO_0000296 organelle distribution The localization and placement of endoplasmic reticulum (ER) within a cell or between separating cells. http://purl.obolibrary.org/obo/APO_0000301 Golgi distribution http://purl.obolibrary.org/obo/APO_0000296 organelle distribution The localization and placement of the Golgi apparatus within a cell or between separating cells. http://purl.obolibrary.org/obo/APO_0000302 vesicle distribution http://purl.obolibrary.org/obo/APO_0000296 organelle distribution The localization and placement of secretory, endocytic, or undefined vesicles within a cell or between separating cells. http://purl.obolibrary.org/obo/APO_0000303 endomembrane system morphology http://purl.obolibrary.org/obo/APO_0000226 subcellular morphology The size, shape, or appearance of components of the endomembrane system, which includes the nuclear envelope, endoplasmic reticulum, Golgi apparatus, peroxisomes, vacuoles, and endocytic and exocytic vesicles. http://purl.obolibrary.org/obo/APO_0000304 heterozygous diploid, classical genetics http://purl.obolibrary.org/obo/APO_0000020 classical genetics Any classical genetics experiment carried out in a heterozygous diploid background. http://purl.obolibrary.org/obo/APO_0000305 homozygous diploid, classical genetics http://purl.obolibrary.org/obo/APO_0000020 classical genetics Any classical genetics experiment carried out in a homozygous diploid background. http://purl.obolibrary.org/obo/APO_0000306 conidial germination http://purl.obolibrary.org/obo/APO_0000295 conidiation The production of viable cells arising from conidia, or asexual spores. http://purl.obolibrary.org/obo/APO_0000307 anaerobic growth http://purl.obolibrary.org/obo/APO_0000210 anaerobic metabolism Growth in the absence of oxygen. http://purl.obolibrary.org/obo/APO_0000308 fermentative growth http://purl.obolibrary.org/obo/APO_0000101 fermentative metabolism Growth while utilizing a fermentable carbon source. http://purl.obolibrary.org/obo/APO_0000309 respiratory growth http://purl.obolibrary.org/obo/APO_0000102 respiratory metabolism Growth while utilizing a nonfermentable carbon source. http://purl.obolibrary.org/obo/APO_0000310 growth in exponential phase http://purl.obolibrary.org/obo/APO_0000106 vegetative growth Growth in liquid culture during the exponential phase. http://purl.obolibrary.org/obo/APO_0000311 growth in post-diauxic phase http://purl.obolibrary.org/obo/APO_0000106 vegetative growth Growth in liquid culture during the post-diauxic phase. http://purl.obolibrary.org/obo/APO_0000312 cell death http://purl.obolibrary.org/obo/APO_0000066 cellular processes The cessation of the life of an individual cell. http://purl.obolibrary.org/obo/APO_0000313 autolysis http://purl.obolibrary.org/obo/APO_0000312 cell death A regulated form of cell death that occurs in stationary phase mycelial cultures of filamentous fungi, often in response to carbon starvation. It is characterized by cell wall degradation, hyphal fragmentation and vacuolization, production of intracellular and extracellular hydrolases, and release of ammonia. http://purl.obolibrary.org/obo/APO_0000314 cell lysis http://purl.obolibrary.org/obo/APO_0000312 cell death The breaking apart of a fully formed cell. http://purl.obolibrary.org/obo/APO_0000315 plasma membrane morphology http://purl.obolibrary.org/obo/APO_0000226 subcellular morphology The size, shape, or appearance of the plasma membrane. http://purl.obolibrary.org/obo/APO_0000316 chronological lifespan http://purl.obolibrary.org/obo/APO_0000030 lifespan The number of days that a culture remains viable in stationary phase. http://purl.obolibrary.org/obo/APO_0000317 replicative lifespan http://purl.obolibrary.org/obo/APO_0000030 lifespan The number of divisions that a cell undergoes before dying. http://purl.obolibrary.org/obo/APO_0000318 Affinity Capture-Luminescence http://purl.obolibrary.org/obo/APO_0000187 physical interactions An interaction is inferred when a bait protein, tagged with luciferase, is enzymatically detected in immunoprecipitates of the prey protein as light emission. The prey protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag. http://purl.obolibrary.org/obo/APO_0000319 chlamydospore formation http://purl.obolibrary.org/obo/APO_0000023 development Formation of chlamydospores, which are large, asexual, one-celled spores with a thickened, refractile cell wall that are borne on the ends of suspensor cells attached to hyphae or pseudohyphae. http://purl.obolibrary.org/obo/APO_0000320 germ tube formation http://purl.obolibrary.org/obo/APO_0000027 filamentous growth Formation of an elongated evagination that develops from a yeast-form cell and continues growth to become a hyphal cell. The initiation of germ tube growth is referred to as the yeast-to-hyphal transition. http://purl.obolibrary.org/obo/APO_0000321 phenotypic switching http://purl.obolibrary.org/obo/APO_0000023 development The ability to undergo a reversible change from one distinct phenotype to another, resulting from changes in gene expression rather than from mutation. Cells in a specific phenotypic state have a distinct cellular morphology, which may be reflected in distinct colony morphology and different cellular properties, such as the ability to mate. A well-known example of phenotypic switching is the white-opaque switch of Candida albicans. http://purl.obolibrary.org/obo/APO_0000324 resistance to killing by host cells http://purl.obolibrary.org/obo/APO_0000287 interaction with host/environment The ability of a pathogen to survive an attack by host cells such as neutrophils. http://purl.obolibrary.org/obo/APO_0000325 resistance to phagocytosis http://purl.obolibrary.org/obo/APO_0000287 interaction with host/environment The ability of a pathogen to evade or escape phagocytosis by host cells such as macrophages. http://purl.obolibrary.org/obo/APO_0000326 desiccation resistance http://purl.obolibrary.org/obo/APO_0000080 stress resistance The level of resistance to air-drying or desiccation stress. http://purl.obolibrary.org/obo/APO_0000327 hydrostatic pressure resistance http://purl.obolibrary.org/obo/APO_0000080 stress resistance The level of resistance to increased hydrostatic pressure. http://purl.obolibrary.org/obo/APO_0000328 unknown ploidy, classical genetics http://purl.obolibrary.org/obo/APO_0000020 classical genetics Any classical genetics experiment carried out in a background where the ploidy of the mutation or strain is unknown. http://purl.obolibrary.org/obo/APO_0000329 induction of host response http://purl.obolibrary.org/obo/APO_0000287 interaction with host/environment The induction of host immune cell differentiation, cytokine secretion, cytokine transcriptional regulation or other related host responses to infection by or contact with a microbe. http://purl.obolibrary.org/obo/APO_0000330 haploproficient http://purl.obolibrary.org/obo/APO_0000216 fitness The heterozygous diploid displays an increased growth rate relative to a diploid that is homozygous wild type at that locus. http://purl.obolibrary.org/obo/APO_0000331 capsule formation http://purl.obolibrary.org/obo/APO_0000291 formation of anatomical structure The formation of a coating of extracellular polysaccharide material, as in fungi such a Cryptococcus. http://purl.obolibrary.org/obo/APO_0000332 peg formation http://purl.obolibrary.org/obo/APO_0000291 formation of anatomical structure Formation of a protrusion in a subapical hyphal cell that fuses with a clamp cell to form a fused clamp, in Basidiomycetes. http://purl.obolibrary.org/obo/APO_0000333 acquired thermotolerance http://purl.obolibrary.org/obo/APO_0000093 thermotolerance The ability to survive a period of exposure to an acute heat shock after brief pretreatment at a mildly elevated temperature. http://purl.obolibrary.org/obo/APO_0000334 innate thermotolerance http://purl.obolibrary.org/obo/APO_0000093 thermotolerance The natural or innate ability of a cell to survive a period of exposure to an acute heat shock without pretreatment. http://purl.obolibrary.org/obo/APO_0000335 size of nucleolus http://purl.obolibrary.org/obo/APO_0000273 nucleolar morphology The size of the nucleolus. http://purl.obolibrary.org/obo/APO_0000336 aneuploidy http://purl.obolibrary.org/obo/APO_0000143 chromosome/plasmid maintenance The gain or loss of a chromosome, so that the cell has a number of chromosomes that is not a multiple of the usual complement. Aneuploidy may also be partial, affecting a large segment of a chromosome that is lost or translocated to a different chromosome. http://purl.obolibrary.org/obo/APO_0000337 polyploidy http://purl.obolibrary.org/obo/APO_0000143 chromosome/plasmid maintenance The gain of an entire set or sets of chromosomes beyond the usual complement. http://purl.obolibrary.org/obo/APO_0000338 micronucleophagy http://purl.obolibrary.org/obo/APO_0000074 autophagy A form of microautophagy selective for the nucleus that occurs in response to starvation, damage or during a shift in environmental conditions. http://purl.obolibrary.org/obo/APO_0000339 ribophagy http://purl.obolibrary.org/obo/APO_0000074 autophagy A form of macroautophagy selective for ribosomes that occurs in response to starvation, damage or during a shift in environmental conditions. http://purl.obolibrary.org/obo/APO_0000340 reticulophagy http://purl.obolibrary.org/obo/APO_0000074 autophagy A form of macroautophagy selective for the endoplasmic reticulum that occurs in response to starvation, ER stress, aggregate accumulation or during a shift in environmental conditions. http://purl.obolibrary.org/obo/APO_0000341 nucleophagy http://purl.obolibrary.org/obo/APO_0000074 autophagy Selective degradation of nucleoplasm that occurs upon nitrogen starvation, in which parts of the nucleus and perinuclear ER are packaged into autophagosomes and delivered to the vacuole for degradation. In S. cerevisiae, Atg39p is involved in this process. http://purl.obolibrary.org/obo/APO_0000342 late nucleophagy http://purl.obolibrary.org/obo/APO_0000074 autophagy The autophagic degradation of bulk nucleoplasm that occurs after prolonged nitrogen starvation. In late nucleophagy, delivery of the nuclear cargo to the vacuole does not involve autophagosomes. http://purl.obolibrary.org/obo/APO_0000164 interactions http://purl.obolibrary.org/obo/APO_0000018 experiment_type http://purl.obolibrary.org/obo/APO_0000192 phenotype assays http://purl.obolibrary.org/obo/APO_0000018 experiment_type http://purl.obolibrary.org/obo/APO_0000160 hyphal growth http://purl.obolibrary.org/obo/APO_0000027 filamentous growth http://purl.obolibrary.org/obo/APO_0000186 genetic interactions http://purl.obolibrary.org/obo/APO_0000164 interactions http://purl.obolibrary.org/obo/APO_0000187 physical interactions http://purl.obolibrary.org/obo/APO_0000164 interactions http://purl.obolibrary.org/obo/APO_0000322 Negative Genetic http://purl.obolibrary.org/obo/APO_0000186 genetic interactions http://purl.obolibrary.org/obo/APO_0000171 Dosage Growth Defect http://purl.obolibrary.org/obo/APO_0000186 genetic interactions http://purl.obolibrary.org/obo/APO_0000172 Dosage Lethality http://purl.obolibrary.org/obo/APO_0000186 genetic interactions http://purl.obolibrary.org/obo/APO_0000173 Dosage Rescue http://purl.obolibrary.org/obo/APO_0000186 genetic interactions http://purl.obolibrary.org/obo/APO_0000174 Epistatic MiniArray Profile http://purl.obolibrary.org/obo/APO_0000186 genetic interactions http://purl.obolibrary.org/obo/APO_0000177 Phenotypic Enhancement http://purl.obolibrary.org/obo/APO_0000186 genetic interactions http://purl.obolibrary.org/obo/APO_0000178 Phenotypic Suppression http://purl.obolibrary.org/obo/APO_0000186 genetic interactions http://purl.obolibrary.org/obo/APO_0000182 Synthetic Growth Defect http://purl.obolibrary.org/obo/APO_0000186 genetic interactions http://purl.obolibrary.org/obo/APO_0000183 Synthetic Lethality http://purl.obolibrary.org/obo/APO_0000186 genetic interactions http://purl.obolibrary.org/obo/APO_0000184 Synthetic Rescue http://purl.obolibrary.org/obo/APO_0000186 genetic interactions http://purl.obolibrary.org/obo/APO_0000272 Synthetic Haploinsufficiency http://purl.obolibrary.org/obo/APO_0000186 genetic interactions http://purl.obolibrary.org/obo/APO_0000323 Positive Genetic http://purl.obolibrary.org/obo/APO_0000186 genetic interactions http://purl.obolibrary.org/obo/APO_0000162 Affinity Capture-MS http://purl.obolibrary.org/obo/APO_0000187 physical interactions http://purl.obolibrary.org/obo/APO_0000163 Affinity Capture-RNA http://purl.obolibrary.org/obo/APO_0000187 physical interactions http://purl.obolibrary.org/obo/APO_0000165 Affinity Capture-Western http://purl.obolibrary.org/obo/APO_0000187 physical interactions http://purl.obolibrary.org/obo/APO_0000166 Biochemical Activity http://purl.obolibrary.org/obo/APO_0000187 physical interactions http://purl.obolibrary.org/obo/APO_0000167 Co-crystal Structure http://purl.obolibrary.org/obo/APO_0000187 physical interactions http://purl.obolibrary.org/obo/APO_0000168 Co-fractionation http://purl.obolibrary.org/obo/APO_0000187 physical interactions http://purl.obolibrary.org/obo/APO_0000169 Co-localization http://purl.obolibrary.org/obo/APO_0000187 physical interactions http://purl.obolibrary.org/obo/APO_0000170 Co-purification http://purl.obolibrary.org/obo/APO_0000187 physical interactions http://purl.obolibrary.org/obo/APO_0000175 FRET http://purl.obolibrary.org/obo/APO_0000187 physical interactions http://purl.obolibrary.org/obo/APO_0000176 Far Western http://purl.obolibrary.org/obo/APO_0000187 physical interactions http://purl.obolibrary.org/obo/APO_0000179 Protein-RNA http://purl.obolibrary.org/obo/APO_0000187 physical interactions http://purl.obolibrary.org/obo/APO_0000180 Protein-peptide http://purl.obolibrary.org/obo/APO_0000187 physical interactions http://purl.obolibrary.org/obo/APO_0000181 Reconstituted Complex http://purl.obolibrary.org/obo/APO_0000187 physical interactions http://purl.obolibrary.org/obo/APO_0000185 Two-hybrid http://purl.obolibrary.org/obo/APO_0000187 physical interactions http://purl.obolibrary.org/obo/APO_0000188 Affinity Chromatography http://purl.obolibrary.org/obo/APO_0000187 physical interactions http://purl.obolibrary.org/obo/APO_0000189 Affinity Precipitation http://purl.obolibrary.org/obo/APO_0000187 physical interactions http://purl.obolibrary.org/obo/APO_0000190 Biochemical Assay http://purl.obolibrary.org/obo/APO_0000187 physical interactions http://purl.obolibrary.org/obo/APO_0000191 Purified Complex http://purl.obolibrary.org/obo/APO_0000187 physical interactions http://purl.obolibrary.org/obo/APO_0000244 PCA http://purl.obolibrary.org/obo/APO_0000187 physical interactions http://purl.obolibrary.org/obo/APO_0000001 qualifier The direction of change in the mutant compared to wild type. http://purl.obolibrary.org/obo/APO_0000006 mutant_type A description of the effect of the mutation on the gene product function. http://purl.obolibrary.org/obo/APO_0000016 not yet recorded OBSOLETE. This term was not defined before being made obsolete. http://purl.obolibrary.org/obo/APO_0000017 observable Features of ascomycete fungal cells, cultures, or colonies that can be detected, observed, measured, or monitored. http://purl.obolibrary.org/obo/APO_0000018 experiment_type A description of the experimental approach. http://purl.obolibrary.org/obo/APO_0000019 systematic null mutation set OBSOLETE. Robotic generation and analysis of large-scale, genome-wide knockout sets. http://purl.obolibrary.org/obo/APO_0000067 cell cycle arrest in G1 phase OBSOLETE. This term was not defined before being made obsolete. http://purl.obolibrary.org/obo/APO_0000068 cell cycle arrest at G2 phase OBSOLETE. This term was not defined before being made obsolete. http://purl.obolibrary.org/obo/APO_0000069 cell cycle arrest at START OBSOLETE. This term was not defined before being made obsolete. http://purl.obolibrary.org/obo/APO_0000070 cell cycle arrest OBSOLETE. This term was not defined before being made obsolete. http://purl.obolibrary.org/obo/APO_0000088 drug resistance OBSOLETE. This term was not defined before being made obsolete. http://purl.obolibrary.org/obo/APO_0000103 respiratory growth rate OBSOLETE. http://purl.obolibrary.org/obo/APO_0000107 growth rate in exponential phase OBSOLETE: Growth rate in liquid culture during the exponential phase. http://purl.obolibrary.org/obo/APO_0000108 growth rate in post-diauxic phase OBSOLETE: Growth rate in liquid culture during the post-diauxic phase. http://purl.obolibrary.org/obo/APO_0000115 other method OBSOLETE. This term defined as 'novel techniques' has been obsoleted as it was a remnant of the original mutant types that has not been used. http://purl.obolibrary.org/obo/APO_0000116 other mutant type OBSOLETE. This term was not defined before being made obsolete. http://purl.obolibrary.org/obo/APO_0000121 bud direction OBSOLETE: This term was not defined before being obsoleted. http://purl.obolibrary.org/obo/APO_0000122 cell cycle arrest in M phase OBSOLETE. This term was not defined before being made obsolete. http://purl.obolibrary.org/obo/APO_0000133 cell cycle arrest in metaphase OBSOLETE. This term was not defined before being made obsolete. http://purl.obolibrary.org/obo/APO_0000134 cell cycle arrest at the metaphase - anaphase transition OBSOLETE. This term was not defined before being made obsolete. http://purl.obolibrary.org/obo/APO_0000135 cell cycle arrest in anaphase OBSOLETE. This term was not defined before being made obsolete. http://purl.obolibrary.org/obo/APO_0000136 cell cycle arrest in early anaphase OBSOLETE. This term was not defined before being made obsolete. http://purl.obolibrary.org/obo/APO_0000137 cell cycle arrest in mid anaphase OBSOLETE. This term was not defined before being made obsolete. http://purl.obolibrary.org/obo/APO_0000138 cell cycle arrest in late anaphase OBSOLETE. This term was not defined before being made obsolete. http://purl.obolibrary.org/obo/APO_0000139 cell cycle arrest in telophase OBSOLETE. This term was not defined before being made obsolete. http://purl.obolibrary.org/obo/APO_0000140 cell cycle arrest in G0 (stationary phase) OBSOLETE. This term was not defined before being made obsolete. http://purl.obolibrary.org/obo/APO_0000146 systematic repressible mutation set OBSOLETE. This term was not defined before being made obsolete. http://purl.obolibrary.org/obo/APO_0000150 null homozygous diploid OBSOLETE. Mutation abolishes function of both alleles of the gene in a diploid strain. http://purl.obolibrary.org/obo/APO_0000151 null heterozygous diploid OBSOLETE. Mutation abolishes function of one allele of the gene in a diploid strain. http://purl.obolibrary.org/obo/APO_0000156 fermentative growth rate OBSOLETE: The rate of growth in the presence of a fermentable carbon source. http://purl.obolibrary.org/obo/APO_0000161 multiple OBSOLETE. This term was not defined before being made obsolete. http://purl.obolibrary.org/obo/APO_0000206 heterozygous diploid OBSOLETE. This term was not defined before being made obsolete. http://purl.obolibrary.org/obo/APO_0000207 homozygous diploid OBSOLETE. This term was not defined before being made obsolete. http://purl.obolibrary.org/obo/APO_0000211 anaerobic growth rate OBSOLETE: The rate of growth in the absence of oxygen. http://purl.obolibrary.org/obo/APO_0000227 cell cycle arrest in S phase OBSOLETE. Arrest of cells in the S phase of the cell cycle, the phase in which DNA replication occurs. http://purl.obolibrary.org/obo/APO_0000238 cell cycle arrest at the G2/M phase transition OBSOLETE. Arrest of cells at the transition between the G2 and M phases of the mitotic cell cycle. http://purl.obolibrary.org/obo/APO_0000290 allergy induction OBSOLETE: The induction of an allergic response in the host organism.