Term IRI Term label Parent term IRI Parent term label Alternative term Definition http://www.bioassayontology.org/bao#BAO_0002434 gene knockdown by RNA interference http://www.bioassayontology.org/bao#BAO_0002433 gene knockdown gene knockdown by RNA interference Double-stranded RNA is synthesized with a sequence complementary to a gene of interest and introduced into a cell or organism, where it is recognized as exogenous genetic material and activates the RNAi pathway. Using this mechanism, researchers can cause a drastic decrease in the expression of a targeted gene. http://www.bioassayontology.org/bao#BAO_0000348 80 percent inhibition http://www.bioassayontology.org/bao#BAO_0000201 percent inhibition 80% inhibition 80% reduction of a predefined stimulus. Unit of Measure is always % when normalized to the dynamic range of the assay. http://purl.obolibrary.org/obo/CLO_0009047 SK-MEL-5 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 SK-MEL-5 A melanoma cell line cell. This cell line was established in 1974 from a metastatic site (axillary lymph node) in a 24-year-old Caucasian female with malignant melanoma, expresses mutant B-Raf (V600E) and wildtype N-Ras. http://purl.obolibrary.org/obo/CLO_0009905 SNB75 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 SNB75 A human glioblastoma cell line cell. The cell line is part of the NCI-60 screening panel. http://www.bioassayontology.org/bao#BAO_0040003 background correction http://www.bioassayontology.org/bao#BAO_0040002 image correction flat field correction; shading correction Background correction is a data transformation designed to remove irrelevant contributions from the measured signal, e.g. those due to instrument noise or sample preparation. http://www.bioassayontology.org/bao#BAO_0000349 50 percent cell viability http://www.bioassayontology.org/bao#BAO_0000202 percent cell viability 50% viability Assay has 50% living cells. Unit of Measure is always % when normalized to the dynamic range of the assay. http://www.bioassayontology.org/bao#BAO_0000449 electron microscopy http://www.bioassayontology.org/bao#BAO_0002526 microscopy EM Electron microscopy involve the diffraction, reflection, or refraction of electron beams interacting with the subject of study, and the subsequent collection of this scattered radiation in order to build up an image. http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0000001 细胞系细胞 连续细胞系细胞 A cell line cell that is expected to be capable of an unlimited number of divisions, and is thus able to support indefinite propagation in vitro as part of an immortal cell line. http://www.bioassayontology.org/bao#BAO_0000412 LNA http://www.bioassayontology.org/bao#BAO_0000270 RNA locked nucleic acid Locked nucleic acid (LNA) is a nucleic acid analogue containing one or more LNA nucleotide monomers with a bicyclic furanose unit locked in an RNA mimicking sugar conformation. LNA oligonucleotides have high affinity toward complementary single-stranded RNA and complementary single- or double-stranded DNA. This makes LNA suitable for sequence specific targeting of RNA in vitro or in vivo. http://www.bioassayontology.org/bao#BAO_0002146 MIC http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint minimum inhibitory concentration The lowest concentration of an inhibitor (antimicrobial agent) required to inhibit the growth of a microorganism. http://www.bioassayontology.org/bao#BAO_0000347 50 percent inhibition http://www.bioassayontology.org/bao#BAO_0000201 percent inhibition 50% inhibition 50% reduction of a predefined stimulus. Unit of Measure is always % when normalized to the dynamic range of the assay. http://www.bioassayontology.org/bao#BAO_0003040 Vd http://www.bioassayontology.org/bao#BAO_0002758 volume endpoint Volume of distribution Volume of Distribution is defined as the theoretical volume in which the total drug administered would need to be distributed to produce the concentration that is observed in plasma. Measured as the total amount of drug in the body divided by the concentration of drug in the plasma. http://www.bioassayontology.org/bao#BAO_0002785 gene expression assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics gene expression assay This assay quantifies the expression level of the entire gene pool in a cell or a subpopulation (e.g. tissue-specific gene expression, kinases) using either microarray, bead method, RNASeq, or reporter gene method. http://www.bioassayontology.org/bao#BAO_0000316 genomic DNA http://www.bioassayontology.org/bao#BAO_0000269 DNA linear deoxyribonucleic acid DNA that is linear and not circular. Examples of linear DNA include synthetic oligonucleotide, restriction endonuclease digestion product, polymerase chain reaction product, mechanically sheared genomic DNA, etc. http://www.bioassayontology.org/bao#BAO_0000003 fluorescence polarization http://www.bioassayontology.org/bao#BAO_0000046 fluorescence method FP Fluorescence polarization (FP) measurements are based on the assessment of the rotational motions of species. It is used to measure binding interactions. When linear polarized light is used to excite fluorophores, only those aligned with the plane of polarization will be excited. For fluorophores attached to small, rapidly rotating molecules, the initially photoselected orientational distribution becomes randomized prior to emission, resulting in low fluorescence polarization. But binding of the low molecular weight tracer to a large, slowly rotating molecule results in high fluorescence polarization. http://www.bioassayontology.org/bao#BAO_0000189 GI50 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint growth inhibition by 50% The effective concentration of a growth inhibitor, which produces 50% of the maximum possible response for that inhibitor. GI50 is calculated from [(Ti-Tz)/(C-Tz)] x 100 = 50, where Tz is absorbance at time zero, Ti is absorbance in the presence of test drug, and C is absorbance in the control (untreated cells). As a measure of viable or proliferating cells, different researchers measure different parameters, namely, protein content (by sulforhodamine B staining followed by absorbance measurement), mitochondrial dehydrogenase activity (by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrasodium bromide, known as MTT staining followed by absorbance measurement), expression of proliferation associated antigens (by immunostaining for Ki-67), and ATP content (by using CellTiter-Glo reagent (Promega) followed by luminescence measurement). http://www.bioassayontology.org/bao#BAO_0003042 F http://www.bioassayontology.org/bao#BAO_0002118 graphical calculation endpoint Bioavailability Bioavailability is a subcategory of absorption and is the fraction (or %) of unchanged drug that reaches the systemic circulation, thereby accessing the site of action. It is usually determined as the ratio of AUC(oral)/AUC(iv). http://www.bioassayontology.org/bao#BAO_0000001 fluorescence resonance energy transfer http://www.bioassayontology.org/bao#BAO_0000046 fluorescence method FRET Fluorescence resonance energy transfer (FRET) is based on the transfer of energy between two fluorophores, a donor and an acceptor, when in close proximity. The energy transfer is directed from higher-energy donor fluorophore to lower-energy acceptor fluorophore of labeled protein pairs. Target protein pairs are likely to exhibit FRET if they are no more than 10 nm apart. http://www.bioassayontology.org/bao#BAO_0000656 efficacy http://www.bioassayontology.org/bao#BAO_0000082 percent response Efficacy The maximum response that can be achieved with the perturbagen as percentage of the positive control. http://www.bioassayontology.org/bao#BAO_0002667 90 percent inhibition http://www.bioassayontology.org/bao#BAO_0000201 percent inhibition 90% inhibition 90% reduction of a predefined stimulus. Unit of Measure is always % when normalized to the dynamic range of the assay. http://www.bioassayontology.org/bao#BAO_0003039 IZ http://www.bioassayontology.org/bao#BAO_0002118 graphical calculation endpoint Inhibition zone In the disk diffusion susceptibility test, the zone of inhibition is the clear area surrounding an antimicrobial disk where bacterial growth is inhibited, usually measured as a diameter. The diameter of the zone of inhibition is proportional to the susceptibility of the organism tested. http://www.bioassayontology.org/bao#BAO_0000194 TGI http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint total growth inhibition TGI is total growth inhibition, which is the effective concentration of a growth inhibitor, which produces 0% relative growth for that inhibitor. Thus TGI signifies a cytostatic effect. tgi is calculated from [(Ti-Tz)/(C-Tz)] x 100 =0, where Ti = Tz and Tz is absorbance at time zero, Ti is absorbance in the presence of test drug, and C is absorbance in the control (untreated cells). As a measure of viable cells, different researchers measure different parameters, namely, protein content (by sulforhodamine B staining followed by absorbance measurement), mitochondrial dehydrogenase activity (by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrasodium bromide, known as MTT staining followed by absorbance measurement), and ATP content (by using CellTiter-Glo reagent (Promega) followed by luminescence measurement). http://www.bioassayontology.org/bao#BAO_0000410 endpoint assay http://www.bioassayontology.org/bao#BAO_0000409 assay measurement type end-point assay Reported results do not have a time dimension, but represent a static response. This does not mean that the result is indepent from the time of measurement, such as cell viablity at 12, 24 or 72h where the time point is associated metadata. http://www.bioassayontology.org/bao#BAO_0000428 isothermal titration calorimetry http://www.bioassayontology.org/bao#BAO_0000427 label free method ITC ITC is a thermodynamic technique that can directly measure the heat released or absorbed during a biomolecular binding event. It can measure the binding affinity (Ka), reaction stoichiometry (n), enthalpy (∆H) and entropy (ΔS) of the interaction between two or more molecules in solution. http://www.bioassayontology.org/bao#BAO_0000002 homogeneous time resolved fluorescence http://www.bioassayontology.org/bao#BAO_0000001 fluorescence resonance energy transfer HTRF Homogenous time resolved fluorescence (HTRF) is a technology which combines standard FRET technology with the time-resolved measurement of fluorescence. Through this, HTRF eliminates the short-lived background fluorescence. Introducing a time delay (50-150 micro seconds) between the system excitation and fluorescence measurement, which allows the signal to be cleared of all non-specific short lived emissions. http://www.bioassayontology.org/bao#BAO_0000004 time resolved fluorescence resonance energy transfer http://www.bioassayontology.org/bao#BAO_0000001 fluorescence resonance energy transfer TR-FRET Time resolved-fluorescence resonance energy transfer (TR-FRET) unites TRF (Time-Resolved Fluorescence) and FRET (Fluorescence Resonance Energy Transfer) principles. This combination brings together the low background benefits of TRF with the homogeneous assay format of FRET. Introducing a time delay (50-150 micro seconds) between the system excitation and fluorescence measurement allows the signal to be cleared of all non-specific short lived emissions. TR-FRET uses lanthanide donors which are fluorophores with long emission half-lives. http://www.bioassayontology.org/bao#BAO_0000006 percent cytotoxicity http://www.bioassayontology.org/bao#BAO_0000201 percent inhibition % cytotoxicity It is a measure of the number of dead cells in a culture well. We consider it as a subclass of 'percent inhibition', because cell death is induced by inhibition of vital cellular processes and percent cytotoxicity increases as the number of dead cells increases. It can be estimated in the compound treated wells in comparison to vehicle-treated control wells and is expressed as a percent. The compound treatment is preferably performed in a short window of time to avoid masking the effect due to cell proliferation. Compound cytotoxicity is an important parameter to measure when developing potential human therapeutics. Cytotoxicity is determined as a measure of radioisotope (3H thymidine or 51Cr) release, lactate dehydrogenase release from damaged cells, tetrazolium salt and alamar blue reduction, fluorescent dyes that selectively stain live or dead cells, and decrease in ATP content. ATP levels are detected using a luminescence based assay kit such as CellTiter-Glo (Promega). ATP values higher than controls indicate proliferation and cultures with ATP concentrations lower than controls indicate cytotoxicity. Percent cytotoxicity = 100-percent viability http://www.bioassayontology.org/bao#BAO_0000010 functional http://www.bioassayontology.org/bao#BAO_0000008 bioassay type functional assay An assay where the measured signal corresponds to a direct read out of the analyte (e.g. enzyme activity) or an indirect complex response such as cell survival, proliferation, localization of a protein, nuclear translocation etc. http://www.bioassayontology.org/bao#BAO_0000017 scintillation proximity assay http://www.bioassayontology.org/bao#BAO_0000405 scintillation counting SPA Scintillation proximity assay (SPA) eliminates the separation step of unbound radioisotopes and is performed using low energy radioisotopes (3H and 125I) as labels, which have short range electron emission. SPA involves the use of microscopic beads which are first coated with a receptor protein of interest and contain a scintillant. When stimulated by the binding of radio-labeled ligand molecules, they emit light, which is detected by the photomultiplier tube. SPA is suitable for high throughput since the protocol has no wash or separation steps. http://www.bioassayontology.org/bao#BAO_0000031 primary assay http://www.bioassayontology.org/bao#BAO_0000029 assay screening campaign stage primary screening The first assay performed in a in a screening campaign. The purpose of the primary assay is to identify hits, which are potentially biologically active chemical entities. Generally in this assay, the perturbagens are tested at a single concentration with only one measurement. It is followed by a confirmatory screen, which can be run at a single concentration with multiple replicates or as concentration-response assay. http://www.bioassayontology.org/bao#BAO_0000041 binding type http://www.bioassayontology.org/bao#BAO_0000008 bioassay type binding type Binding assays are performed to understand the interaction between two molecules, e.g. perturbagen-protein, protein-protein, protein-DNA, etc. http://www.bioassayontology.org/bao#BAO_0000054 surface plasmon resonance http://www.bioassayontology.org/bao#BAO_0000057 optical based SPR For surface plasmon resonance measurements, target protein is immobilized onto a solid surface via covalent or noncovalent interaction. Binding of small molecule compounds changes the refractive index of the immobilized target, which can be detected by optical sensing. Shift in wavelength of light is proportional to mass changes near the sensor surface, with sensitivity to detect mass change being ~300 Da. http://www.bioassayontology.org/bao#BAO_0000055 mass spectrometry http://www.bioassayontology.org/bao#BAO_0000035 physical detection method MS This method is used to detect compounds that are bound to the protein targets. The unbound compounds are separated by affinity based, size exclusion, or ultrafiltration methods. The bound compounds are eluted from the protein and detected by mass spectrometry. Based on the separation method, the throughput varies: between 200-2700 compounds can be loaded in each run for separation. Mass spectrometry is used to determine the chemical structure of molecules. The samples are vaporized, followed by ionization and then the mass to charge ratio of the particles is analyzed. http://www.bioassayontology.org/bao#BAO_0000065 percent inhibition normalization http://www.bioassayontology.org/bao#BAO_0002750 normalization based on control Normalized % inhibition Data normalization obtained by dividing the difference of mean of the positive controls and sample measurement by the difference of the mean of the positive controls and mean of the negative control. http://www.bioassayontology.org/bao#BAO_0000066 bio layer interferometry http://www.bioassayontology.org/bao#BAO_0000057 optical based BLI Bio-Layer Interferometry is a used for measuring biomolecular interactions. In this technique, the interference pattern of white light reflected from two surfaces: a layer of immobilized protein on the biosensor tip, and an internal reference layer are analyzed. Changes in the number of molecules bound to the biosensor tip cause a shift in the interference pattern, which can be measured in real-time. http://www.bioassayontology.org/bao#BAO_0000069 resonant waveguide grating http://www.bioassayontology.org/bao#BAO_0000057 optical based RWG Cells are directly cultured onto the surface of a resonant waveguide grating (RWG) biosensor. The mass redistribution within the bottom portion of cells, mediated by stimulus is directly measured with the biosensor. RWG biosensor utilizes an optical beam with an appropriate angular content to illuminate a waveguide film in which a grating structure is embedded. When this beam is reflected by the sensor surface, the resonant angle dominates in the output beam. The mass redistribution within the sensing volume alters the incident angle. Because of its ability for multiparameter measurements, the biosensor has potential to provide high information content for cell sensing. These parameters include the angular shift (one of the most common outputs), the intensity, the peak width at half-maximum (PWHM), and area of the resonant peaks. http://www.bioassayontology.org/bao#BAO_0000074 mode of action http://www.bioassayontology.org/bao#BAO_0003115 assay result component MOA This refers to the effect of the perturbagen on the target of an assay, whether it brings about inhibition, activation, cytotoxicity, etc. http://www.bioassayontology.org/bao#BAO_0000082 percent response http://www.bioassayontology.org/bao#BAO_0000181 response endpoint % response Percent increase or decrease of a predefined stimulus. Unit of Measure is always % when normalized to the dynamic range of the assay. http://www.bioassayontology.org/bao#BAO_0000096 percent growth inhibition http://www.bioassayontology.org/bao#BAO_0000201 percent inhibition % growth inhibition % growth reduction of a predefined stimulus. Unit of Measure is always % when normalized to the dynamic range of the assay. http://www.bioassayontology.org/bao#BAO_0000126 molecular redistribution determination method http://www.bioassayontology.org/bao#BAO_0002202 assay design method translocation method The technologies used to measure the distribution of organelles and molecules within the cell (proteins, second messengers, metal ions, dyes, etc). This is generally visualized by microscopy. http://www.bioassayontology.org/bao#BAO_0000141 Luciferin 4-monooxygenase http://www.bioassayontology.org/bao#BAO_0000291 oxidoreductase luciferase An oxidative enzyme that catalyzes the conversion of luciferin to oxyluciferin with the concomitant emission of light (luminescence). http://www.bioassayontology.org/bao#BAO_0000150 beta galactosidase induction http://www.bioassayontology.org/bao#BAO_0000125 reporter gene method beta-gal induction Beta galactosidase gene is attached to the regulatory sequence of a gene of interest. The effect of a perturbagen on the expression of the gene of interest could be easily monitored by the detection of the product of beta galactosidase enzyme. http://www.bioassayontology.org/bao#BAO_0000160 nuclear magnetic resonance http://www.bioassayontology.org/bao#BAO_0000427 label free method NMR Nuclear magnetic resonance (NMR) is used to analyze protein-small molecule interactions. This binding interaction is commonly monitored by the chemical shift of the compound. With this technique, both the binding interaction and bound compounds can be detected, which allows pools of 5-100 compounds to be tested for binding. http://www.bioassayontology.org/bao#BAO_0000161 circular dichroism http://www.bioassayontology.org/bao#BAO_0000427 label free method CD Circular dichroism (CD) is a technology for assessing interactions of chiral molecules with circularly polarized electromagnetic rays. Secondary and tertiary structure of proteins will impart a distinct CD to that molecule allowing the use of CD to examine the protein folding under different conditions. Information about conformational properties of nucleic acids can be obtained by CD spectroscopy. http://www.bioassayontology.org/bao#BAO_0000169 dna content estimation http://www.bioassayontology.org/bao#BAO_0000127 viability measurement method deoxyribonucleic acid content Cellular nuclei can be by stained with Hoechst, DAPI, etc, which is a measure of cell viability and proliferation. http://www.bioassayontology.org/bao#BAO_0000184 image-based readout http://www.bioassayontology.org/bao#BAO_0002169 assay readout content High content screening High content screening (HCS) is an automated screening method using live cells to understand various aspects of their biology. HCS employs imaging (bright-field or fluorescence) and analyses in a high throughput format. HCS can be applied to monitor complex cellular aspects, namely, signaling, morphology, phenotype, proliferation, motility, intracellular trafficking, toxicology, RNAi knockdown, and receptor activation. http://www.bioassayontology.org/bao#BAO_0000186 AC50 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint Potency The effective concentration of a perturbagen, which produces 50% of the maximal possible response, which could mean either activation (EC50) or inhibition (IC50) for that perturbagen. http://www.bioassayontology.org/bao#BAO_0000199 pIC50 http://www.bioassayontology.org/bao#BAO_0000190 IC50 -log IC50 pIC50 is -log IC50, where IC50 is the effective concentration of an inhibitor, which produces 50% of the maximum possible response for that inhibitor. http://www.bioassayontology.org/bao#BAO_0000200 percent activation http://www.bioassayontology.org/bao#BAO_0000082 percent response % activation Percent increase of a measureable response relative to some baseline. Unit of Measure is always % when normalized to the dynamic range of the assay. Percent activity measures the increased activity vs. an unperturbed state, i.e. percent activation := percent activity - 100; e.g. an agonist that results in twice the activity would have percent activity = 200 and percent activation = 100. http://www.bioassayontology.org/bao#BAO_0000202 percent cell viability http://www.bioassayontology.org/bao#BAO_0001103 percent activity % viability It is a measure of living cells in a culture well. Unit of Measure is always % when normalized to the dynamic range of the assay. It can be estimated in the compound treated wells in comparison to vehicle-treated control wells and is expressed as a percent. Viability is determined by measuring tetrazolium salt and alamar blue reduction, staining with selective fluorescent dyes, or ATP content. ATP levels are detected using a luminescence based assay kit such as CellTiter-Glo (Promega). ATP values higher than controls indicate proliferation and cultures with ATP concentrations lower than controls indicates cytotoxicity. Percent viability = 100-percent cytotoxicity http://www.bioassayontology.org/bao#BAO_0000226 PNA http://www.bioassayontology.org/bao#BAO_0000270 RNA protein nucleic acid PNA or protein nucleic acid is an artificially synthesized polymer whose backbone is composed of repeating N-(2-aminoethyl)-glycine units linked by peptide bonds. Since PNA does not contain charged phosphate groups in its backbone, the interaction between PNA-DNA is stronger than that between DNA-DNA due to the lack of electrostatic repulsion. http://www.bioassayontology.org/bao#BAO_0000315 cDNA http://www.bioassayontology.org/bao#BAO_0000269 DNA complimentary deoxyribonucleic acid cDNA or complementary DNA is complementary in sequence to a particular messenger RNA (mRNA). It is synthesized from mRNA in a reverse transcription reaction by reverse transcriptase enzyme. cDNA can be cloned in a vector and introduced into cells to bring about the expression of that particular gene in those cells. http://www.bioassayontology.org/bao#BAO_0000317 plasmid DNA http://www.bioassayontology.org/bao#BAO_0000269 DNA plasmid deoxyribonucleic acid Plasmid is a double stranded circular DNA molecule that can replicate independently of the chromosomal DNA. It exists naturally in bacteria and some yeast. In genetic engineering, plasmids are exploited to clone and multiply a gene of interest. Several plasmid vectors are available commercially to introduce cloned DNA into different cell types. http://www.bioassayontology.org/bao#BAO_0000322 miRNA http://www.bioassayontology.org/bao#BAO_0000270 RNA micro ribonucleic acid miRNAs or microRNAs are short RNAs (~22 nucleotides long) that bind to complementary sequences in the three prime untranslated regions (3' UTRs) of target messenger RNA transcripts (mRNAs), usually resulting in gene silencing. http://www.bioassayontology.org/bao#BAO_0000323 shRNA http://www.bioassayontology.org/bao#BAO_0000270 RNA short hairpin ribonucleic acid Short hairpin RNA (shRNA) can be used to achieve stable knockdown of gene expression. shRNA molecules are cloned into lentiviral or other vectors and expressed by a pol III type promoter. http://www.bioassayontology.org/bao#BAO_0000324 siRNA http://www.bioassayontology.org/bao#BAO_0000270 RNA small interfering ribonucleic acid In the RNAi pathway, the double stranded RNAs first get processed into 20-25 nucleotide small interfering RNAs (siRNAs) by an RNase III-like enzyme called Dicer. The siRNAs enter into endoribonuclease-containing complexes known as RNA-induced silencing complexes (RISCs), and bring about the cleavage of the target mRNAs to achieve gene silencing. http://www.bioassayontology.org/bao#BAO_0000411 kinetic assay http://www.bioassayontology.org/bao#BAO_0000409 assay measurement type kinetics assay The measurements and reported outcome / result of the kinetic assay quantify a change / response over a time course; the reported result has a time component, for example a reaction constant or rate. This is in contrast to an endpoint that does not have a time dimension, but is associated with a time point as metadata, such as cell viablity at 12, 24 or 72 hs, but not the speed with which the cells propargate or die. http://www.bioassayontology.org/bao#BAO_0000431 percent control normalization http://www.bioassayontology.org/bao#BAO_0002750 normalization based on control % control The (raw) measurement is normalized as a percentage of the positive control. This is typically done by plate. http://www.bioassayontology.org/bao#BAO_0000454 scanning electron microscopy http://www.bioassayontology.org/bao#BAO_0000449 electron microscopy SEM Scanning electron microscopy (SEM) visualizes details on the surfaces of cells and particles and gives a very nice 3D view. It gives results much like those of the stereo light microscope, and, akin to that, its most useful magnification is in the lower range than that of the transmission electron microscope. http://www.bioassayontology.org/bao#BAO_0000455 transmission electron microscopy http://www.bioassayontology.org/bao#BAO_0000449 electron microscopy TEM Transmission electron microscopy (TEM) is quite similar to the compound light microscope, by sending an electron beam through a very thin slice of the specimen. The resolution limit in 2005 was approximately 0.05 nanometer and has not increased appreciably since that time. http://www.bioassayontology.org/bao#BAO_0000456 quartz crystal microbalance http://www.bioassayontology.org/bao#BAO_0000427 label free method QCM Quartz crystal microbalance (QCM) technology is based on measuring the resonant frequency of piezoelectric quartz crystals. It allows measurement of important cellular parameters such as adhesion, proliferation and cytotoxicity. It is also used for the identification of protein ligands by immobilized receptors. http://www.bioassayontology.org/bao#BAO_0000461 bioluminescence resonance energy transfer http://www.bioassayontology.org/bao#BAO_0000050 bioluminescence BRET BRET is similar to FRET but has a bioluminescent protein such as aequorin as the donor and a fluorescent acceptor, e.g. GFP. The donor emits blue light in the absence of GFP, but when GFP and aequorin are associated as they are in vivo, GFP accepts the energy from aequorin and emits green light. Hence BRET eliminates the disadvantages associated with donor fluorophore activation. http://www.bioassayontology.org/bao#BAO_0000462 chemiluminescence resonance energy transfer http://www.bioassayontology.org/bao#BAO_0000051 chemiluminescence CRET Chemiluminescence resonance energy transfer (CRET) is a resonance energy transfer between chemiluminescent donors and fluorescent acceptors. CRET occurs by the oxidation of a luminescent substrate, such as luminol/hydrogen peroxide reaction catalyzed by horseradish peroxidase. CRET eliminates the disadvantages associated with donor fluorophore activation. http://www.bioassayontology.org/bao#BAO_0000478 selectivity assay http://www.bioassayontology.org/bao#BAO_0000032 secondary assay specificity Assay employed to elucidate the specificity of biologically active chemical entities towards one or more targets that are (closely) related to the (intended) primary target. http://www.bioassayontology.org/bao#BAO_0000494 chloramphenicol acetyltransferase induction http://www.bioassayontology.org/bao#BAO_0000125 reporter gene method CAT induction Chloramphenicol acetyltransferase (CAT) gene is attached to the regulatory sequence of a gene of interest. When induced to express, CAT breaks down the antibiotic chloramphenicol resulting in a resistance against that antibiotic. The effect of a perturbagen on the expression of the gene of interest could easily be monitored by the gain of antibiotic resistance by the cells. http://www.bioassayontology.org/bao#BAO_0000495 DNA aptamer http://www.bioassayontology.org/bao#BAO_0003043 molecular entity deoxyribonucleic acid aptamer Aptamers are synthetic affinity probes. DNA aptamers are oligonucleotides that bind to a specific target molecule, such as small molecules, proteins, nucleic acids and cells. They are created by selecting them from a large random sequence pool through repeated rounds of in vitro selection. http://www.bioassayontology.org/bao#BAO_0000496 RNA aptamer http://www.bioassayontology.org/bao#BAO_0000270 RNA ribonucleic acid aptamer Aptamers are synthetic affinity probes. RNA aptamers are oligonucleotides that bind to a specific target molecule such as small molecules, proteins, nucleic acids and cells. They are created by selecting them from a large random sequence pool, but natural aptamers also exist in riboswitches. http://www.bioassayontology.org/bao#BAO_0000508 microplate http://www.bioassayontology.org/bao#BAO_0000512 assay footprint microwell plate The assay is performed in a microplate, which can either be 96 well, 384 well, or 1536 well plates. http://www.bioassayontology.org/bao#BAO_0000534 single readout http://www.bioassayontology.org/bao#BAO_0002169 assay readout content HTS This is a typical HTS assay, which uses a plate reader and generates one or two readouts, in contrast to high content screening, which can generate tens to hundreds of parameters. http://www.bioassayontology.org/bao#BAO_0000538 lead optimization assay http://www.bioassayontology.org/bao#BAO_0000029 assay screening campaign stage lead profiling screen Assays performed in the lead optimization stage. They are typically concentration-response high quality assays. They can involve a number of different assays depending on the required profile of the desired lead compound. http://www.bioassayontology.org/bao#BAO_0000544 esiRNA http://www.bioassayontology.org/bao#BAO_0000270 RNA Endoribonuclease-prepared siRNA esiRNAs are endoribonuclease-prepared siRNA pools comprised of a heterogeneous mixture of siRNAs that all target the same mRNA sequence. http://www.bioassayontology.org/bao#BAO_0000550 DNA construct http://www.bioassayontology.org/bao#BAO_0003111 biological macromolecule deoxyribonucleic acid construct A brief description of the recombinant DNA created by the insertion of a gene or siRNA encoding DNA of interest into a vector. It includes information on the type of vector, the type of promoter, the selectable markers, etc., which are all considered when sub-cloning a gene of interest. The construct is transfected into cells by various methods. http://www.bioassayontology.org/bao#BAO_0000581 Tm http://www.bioassayontology.org/bao#BAO_0000585 temperature endpoint melting temperature Tm is defined as the midpoint temperatuere of the protein unfolding transition. It is determined by generating a thermal denaturation curve for the target molecule and taking the midpoint temperature between folding and unfolding state of the protein. In nucleic acid thermodynamics, it is the temperature at which 50% of the DNA strands and its perfect complement are in duplex. http://www.bioassayontology.org/bao#BAO_0000591 protein-DNA interaction assay http://www.bioassayontology.org/bao#BAO_0002989 binding assay protein-deoxyribonucleic acid Protein-DNA interaction http://www.bioassayontology.org/bao#BAO_0000593 protein-RNA interaction assay http://www.bioassayontology.org/bao#BAO_0002989 binding assay protein-ribonucleic acid Protein-RNA interaction http://www.bioassayontology.org/bao#BAO_0000650 cAMP redistribution assay http://www.bioassayontology.org/bao#BAO_0000379 second messenger redistribution assay cAMP Cyclic AMP (cAMP) functions as second messenger in cell signaling. http://www.bioassayontology.org/bao#BAO_0000651 cGMP redistribution assay http://www.bioassayontology.org/bao#BAO_0000379 second messenger redistribution assay cGMP Cyclic GMP (cGMP) functions as second messenger in cell signaling. http://www.bioassayontology.org/bao#BAO_0000663 siRNA library http://www.bioassayontology.org/bao#BAO_0000661 perturbagen library small interfering ribonucleic acid library siRNA libraries consist of large number of siRNAs, which represent a single organism, a diseased state, etc. They bring about the cleavage of the target mRNAs to achieve gene silencing. http://www.bioassayontology.org/bao#BAO_0000664 miRNA library http://www.bioassayontology.org/bao#BAO_0000661 perturbagen library micro ribonucleic acid library It is a collection of miRNAs or microRNAs, which represents a single organism, a diseased state, etc. miRNAs bind the complementary sequences in the 3' UTRs of target mRNA transcripts, usually resulting in gene silencing. http://www.bioassayontology.org/bao#BAO_0000684 artifact assay http://www.bioassayontology.org/bao#BAO_0000803 counter screening assay physicochemical profiling assay Artifact (aka 'artefact') assays are performed to help interpret HTS results by testing whether a 'hit' might be due to some inherent physicochemical property of the compound or perturbagen alone - in the absence of any target. Examples include fluorescence, or inhibition of the enzyme luciferase, which are part of common assay designs; another example is solubility (e.g., if a compound aggregates and interferes with an assay readout). http://www.bioassayontology.org/bao#BAO_0000852 Pancreatic trypsin inhibitor http://www.bioassayontology.org/bao#BAO_0000369 secreted aprotinin The drug aprotinin (Trasylol, Bayer), is the bovine version of the small protein basic pancreatic trypsin inhibitor, or BPTI, which inhibits trypsin and related proteolytic enzymes. http://www.bioassayontology.org/bao#BAO_0000973 NIH chemical genomics center http://www.bioassayontology.org/bao#BAO_0000709 research institute NCGC It is an MLPCN comprehensive screening center. http://www.bioassayontology.org/bao#BAO_0002117 LD50 http://www.bioassayontology.org/bao#BAO_0002116 dosage endpoint lethal dose 50% The median lethal dose is the dose required to kill (produce lethality) in 50% of tested population. http://www.bioassayontology.org/bao#BAO_0002123 Cp http://www.bioassayontology.org/bao#BAO_0002122 amplification curve calculated endpoint crossing point Crossing point- In an exponential amplification curve (i.e., qPCR amplification) the value in number of amplification cycles at which the signal enters log phase, as determined by the maximal second derivative of the curve. http://www.bioassayontology.org/bao#BAO_0002124 Cq http://www.bioassayontology.org/bao#BAO_0002122 amplification curve calculated endpoint quantificatoin cycle Quantificatoin cycle; general term, whether defined by Cp or Ct, for the value of interest determined from an exponential amplification curve (such as number of cycles in a PCR reaction). http://www.bioassayontology.org/bao#BAO_0002125 Ct http://www.bioassayontology.org/bao#BAO_0002122 amplification curve calculated endpoint threshold cycle Crossing threshold; in an exponential amplification curve (i.e., qPCR amplification) the value in number of amplification cycles at which the signal crosses a defined threshold. http://www.bioassayontology.org/bao#BAO_0002157 native form http://www.bioassayontology.org/bao#BAO_0000013 primary structure canonical form A quality of a protein of being the predominant form in an organism. http://www.bioassayontology.org/bao#BAO_0002419 enzyme-linked immunosorbent spot assay http://www.bioassayontology.org/bao#BAO_0000134 ELISA ELISPOT assay The ELISPOT assay is based on, and was developed from a modified version of the ELISA immunoassay. ELISPOT assays were originally developed to enumerate B cells secreting antigen-specific antibodies, and have subsequently been adapted for various tasks, especially the identification and enumeration of cytokine-producing cells at the single cell level. Simply put, at appropriate conditions the ELISPOT assay allows visualization of the secretory product of individual activated or responding cells. Each spot that develops in the assay represents a single reactive cell. Thus, the ELISPOT assay provides both qualitative (type of immune protein) and quantitative (number of responding cells) information. http://www.bioassayontology.org/bao#BAO_0002583 pEC50 http://www.bioassayontology.org/bao#BAO_0000188 EC50 -log EC50 pEC50 is -logEC50, where EC50 is the effective concentration of an agonist, which produces 50% of the maximum possible response for that agonist. http://www.bioassayontology.org/bao#BAO_0002759 CL http://www.bioassayontology.org/bao#BAO_0002758 volume endpoint Drug clearance Clearance is the volume of plasma from which the drug is completely removed per unit time, or, alternatively, the volume of plasma that would have to lose all of the drug that it contains within a unit of time to account for an observed rate of drug elimination. http://www.bioassayontology.org/bao#BAO_0002969 assay readout parameter http://www.bioassayontology.org/bao#BAO_0002185 measure group specification measured parameter assay readout parameter is the outcome of image analysis and is most often a calculated value. This includes 'parameters', such as 'intensity', 'count', 'morphology', etc which are all dependent on phenotype, e.g., intensity and count (number of bright spots) are a result of the amount of gene expression, and morphology is dependent on morphological phenotype, which is detected by the expression of a marker. http://www.bioassayontology.org/bao#BAO_0002989 binding assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics ligand binding assay It is performed to quantify the interactions between two molecules, e.g. small molecule-protein, protein-protein, protein-DNA, etc. http://www.bioassayontology.org/bao#BAO_0002994 enzyme activity assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics enzymatic activities It is used to measure the effect of a perturbagen on the enzyme activity, which can be measured either directly or coupled to a secondary signal. http://www.bioassayontology.org/bao#BAO_0002995 transcriptional profiling assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics transcriptomic profiling This assay quantifies the expression level of the entire gene pool in a cell or a subpopulation (e.g. tissue-specific gene expression, kinases) using a bead-based method. http://www.bioassayontology.org/bao#BAO_0003002 signal transduction assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics cell signalling assay This assay measures one of the series of events that are downstream to the receipt of a chemical signal at the cell http://www.bioassayontology.org/bao#BAO_0003003 cytokine secretion assay http://www.bioassayontology.org/bao#BAO_0003002 signal transduction assay cytokine release assay It measures the types and amounts of cytokines that are released as the consequence of a signaling event. Cytokines can be quantitated using ELISA-based kits, PCR array, etc. http://www.bioassayontology.org/bao#BAO_0003005 phosphorylation assay http://www.bioassayontology.org/bao#BAO_0003004 posttranslation modification assay protein phosphorylation assay This assay quantifies the phosphorylation levels of a protein. The phosphorylation status is detected by one of several methods: using phosphorylation specific antibodies followed by western blotting or imaging, mass spectrometry, etc. http://www.bioassayontology.org/bao#BAO_0003006 reporter gene assay http://www.bioassayontology.org/bao#BAO_0010044 targeted transcriptional assay reporter gene assays Reporter gene assay measures the gene expression from a reporter gene. The reporter gene is inserted under the control of a foreign promoter or an artificial regulatory element of interest. Reporters include luciferase, beta galactosidase, beta lactamase, chloramphenicol acetyl transferase, or a fluorescent protein. http://www.bioassayontology.org/bao#BAO_0003008 transporter assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay drug transporter assay This assay quantifies the activity of a transporter that carries proteins, cofactors, ions, drugs, etc. across the cell membranes. Fluorescence-conjugated dyes or radiolabeled ligands are used to quantitate the various molecular entities that are being transported. http://www.bioassayontology.org/bao#BAO_0003009 cell viability assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics viability assays This assay type measures the cellular state of living or dying by measuring an indicator of life or death. Cell life indicators include ATP content, cell number, dehydrogenase activity, DNA content, esterase activity, mitochondrial membrane potential, membrane integrity, and protease activity. Cell death indicators include caspase activity, chromatin condensation, and phospholipid redistribution. http://www.bioassayontology.org/bao#BAO_0003041 Vdss http://www.bioassayontology.org/bao#BAO_0002758 volume endpoint Volume of distribution at steady state The theoretical volume in which the total drug administered would need to be distributed to produce the concentration that is observed in plasma at steady state i.e when the rate of change of amount of drug in the body is zero. VdSS is proportional to the amount of drug in the body versus the plasma concentration of the drug at steady state (pseudo-equilibrium). http://www.bioassayontology.org/bao#BAO_0010006 microsomal stability assay http://www.bioassayontology.org/bao#BAO_0010095 metabolic stability assay microsome stability assay A common in vitro ADME assay that tests the stability of compounds when incubated with liver microsomes (subcellular fractions which contain membrane-bound drug-metabolizing enzymes). Assay is used to measure in vitro intrinsic clearance or to identify metabolites formed. Typically liver microsomes from one or more mammalian species (mouse, rat, dog, monkey, human) are analyzed to understand differences in metabolism. Can be reported as % recovery after a set time (single timepoint), or as half-life (multiple timepoints). http://www.bioassayontology.org/bao#BAO_0010007 plasma stability assay http://www.bioassayontology.org/bao#BAO_0010095 metabolic stability assay plasma stability A common in vitro ADME assay that tests the stability of compounds when incubated with plasma. Assay is used to measure stability of new chemical entities in plasma, as compounds that rapidly degrade in plasma generally show poor in vivo efficacy. Typically lplasma from one or more mammalian species (mouse, rat, dog, monkey, human) are analyzed. Can be reported as % recovery after a set time (single timepoint), or as half-life (multiple timepoints). http://www.bioassayontology.org/bao#BAO_0010008 Caco-2 permeability assay http://www.bioassayontology.org/bao#BAO_0010083 permeability assay Caco-2 permeability A common in vitro ADME assay that uses the Caco-2 cell line (derived from human colon carcinoma) to assess transport in both directions (apical to basolateral (A-B) and basolateral to apical (B-A)) across the cell monolayer), to predict the in vivo absorption of drugs across the gut wall and to investigate drug efflux. http://www.bioassayontology.org/bao#BAO_0010009 physicochemical assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay physicochemical assay Physicochemical assays measure inherent properties of molecules, and include turbidimetric and thermodynamic solubility (in water or PBS), chemical stability, pKa, and lipophilicity (logP and logD) http://www.bioassayontology.org/bao#BAO_0010010 solubility assay http://www.bioassayontology.org/bao#BAO_0010009 physicochemical assay solubility assay A physicochemical assay that measures the maximum solubility of a molecule in a particular solvent (typically water or PBS). http://www.bioassayontology.org/bao#BAO_0010011 in vivo efficacy assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics in vivo efficacy study An in vivo efficacy assay is a study perfromed in a whole, living organism (usually an animal such as a mouse or rat) to test the effects of a treatment on a specific disease modeled in this animal. http://www.bioassayontology.org/bao#BAO_0010026 protein profiling assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics protein quantification assay Protein profiling assays can be used to identify and quantify proteins together with their post-translational modifications http://www.bioassayontology.org/bao#BAO_0010044 targeted transcriptional assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics RNA expression Assays that quantify the expression of a predetermined RNA transcript / set of transcripts http://www.bioassayontology.org/bao#BAO_0010045 RNA-seq gene expression profiling assay http://www.bioassayontology.org/bao#BAO_0002995 transcriptional profiling assay RNA-seq gene expression profiling assay An assay that uses NGS (Next Generation Sequencing) to quantify the expression of the entire RNA transcripts in a cell / cell population http://www.bioassayontology.org/bao#BAO_0010072 parallel artificial membrane permeability assay http://www.bioassayontology.org/bao#BAO_0002182 pharmacokinetic assay PAMPA A method which determines the permeability of substances from a donor compartment, through a lipid-infused artificial membrane into an acceptor compartment. At the beginning of the test, the drug is added to the donor compartment, and the acceptor compartment is drug-free. After an incubation period the amount of drug is measured in each compartment. Mass balance allows calculation of drug that remains in the membrane. It is used as an in vitro model of passive, transcellular permeation to predict oral absorption. PAMPA is an alternative to the cell-based Caco-2 permeability assay http://www.bioassayontology.org/bao#BAO_0040034 lysine ligand covalent binding method http://www.bioassayontology.org/bao#BAO_0040033 ligand covalent binding method the lysine ligand covalent binding method is used to measure binding of an amine-reactive molecule with a lysine residue on a protein of interest. Binding assessment can be measured by protein mass spectrometry or other direct-binding methodology. http://www.bioassayontology.org/bao#BAO_0040035 methionine ligand covalent binding method http://www.bioassayontology.org/bao#BAO_0040033 ligand covalent binding method the methionine ligand covalent binding method is used to measure binding of an thioether-reactive molecule with a methionine residue on a protein of interest. Binding assessment can be measured by protein mass spectrometry or other direct-binding methodology. http://www.bioassayontology.org/bao#BAO_0040036 serine ligand covalent binding method http://www.bioassayontology.org/bao#BAO_0040033 ligand covalent binding method the serine ligand covalent binding method is used to measure binding of an alcohol-reactive molecule with a serine residue on a protein of interest. Binding assessment can be measured by protein mass spectrometry or other direct-binding methodology. http://www.bioassayontology.org/bao#BAO_0040037 tyrosine ligand covalent binding method http://www.bioassayontology.org/bao#BAO_0040033 ligand covalent binding method the tyrosine ligand covalent binding method is used to measure binding of a phenol-reactive molecule with a tyrosine residue on a protein of interest. Binding assessment can be measured by protein mass spectrometry or other direct-binding methodology. http://www.bioassayontology.org/bao#BAO_0040038 N-terminal ligand covalent binding method http://www.bioassayontology.org/bao#BAO_0040033 ligand covalent binding method the N-terminal ligand covalent binding method is used to measure binding of an amine-reactive molecule with the N-terminus of a protein of interest. Binding assessment can be measured by protein mass spectrometry or other direct-binding methodology. http://www.bioassayontology.org/bao#BAO_0040039 threonine ligand covalent binding method http://www.bioassayontology.org/bao#BAO_0040033 ligand covalent binding method the threonine ligand covalent binding method is used to measure binding of an alcohol-reactive molecule with a threonine residue on a protein of interest. Binding assessment can be measured by protein mass spectrometry or other direct-binding methodology. http://www.bioassayontology.org/bao#BAO_0040040 unnatural amino acid ligand covalent binding method http://www.bioassayontology.org/bao#BAO_0040033 ligand covalent binding method the unnatural amino acid ligand covalent binding method is used to measure binding of a reactive molecule with a particular unnatural residue on a protein of interest. Binding assessment can be measured by protein mass spectrometry or other direct-binding methodology. Unnatural amino acids can contain a variety of ‘bioorthogonal’ chemical handles. http://www.bioassayontology.org/bao#BAO_0040041 cysteine ligand covalent binding method http://www.bioassayontology.org/bao#BAO_0040034 lysine ligand covalent binding method the cysteine ligand covalent binding method is used to measure binding of a thiol-reactive molecule with a cysteine residue on a protein of interest. Binding assessment can be measured by protein mass spectrometry or other direct-binding methodology. http://www.bioassayontology.org/bao#BAO_0080035 perturbagen / positive control ratio endpoint http://www.bioassayontology.org/bao#BAO_0000143 percent control percent postive control The property values are divided by the average value for the positive control wells and multiplied by 100: X' = 100*(X/PosAvg) http://www.bioassayontology.org/bao#BAO_0100001 DiFMUP (Molecular Probes) http://www.bioassayontology.org/bao#BAO_0003043 molecular entity 6,8-Difluoro-4-Methylumbelliferyl Phosphate A fluorinated 4-methylumbelliferyl phosphate (MUP) derivative that has a lower pKa than that of MUP, making DiFMUP an excellent substrate for continuously assaying acid phosphatases at low pH. The reaction product of DiFMUP has excitation/emission maxima of ~358/450 nm. http://www.bioassayontology.org/bao#BAO_0100002 alamarBlue http://www.bioassayontology.org/bao#BAO_0003043 molecular entity Alamar Blue alamarBlue is a cell viability assay reagent which contains the cell permeable, non-toxic, and weakly fluorescent blue indicator dye called resazurin. http://www.bioassayontology.org/bao#BAO_0100003 Alexa555 http://purl.obolibrary.org/obo/CHEBI_51121 fluorescent dye Alexa555 Fluorescent dye with an excitation/emission maxima of ~555/580 nm. http://www.bioassayontology.org/bao#BAO_0100004 Alexa568 http://purl.obolibrary.org/obo/CHEBI_51121 fluorescent dye Alexa568 Fluorescent dye with an excitation/emission maxima of ~578/603 nm. http://www.bioassayontology.org/bao#BAO_0100005 ammonium acetate http://www.bioassayontology.org/bao#BAO_0003043 molecular entity AmOAc Common buffer component with the chemical formula NH4CH3CO2. http://www.bioassayontology.org/bao#BAO_0100006 beta-mercaptoethanol http://www.bioassayontology.org/bao#BAO_0003043 molecular entity β-mercaptoethanol Used to reduce disulfide bonds http://www.bioassayontology.org/bao#BAO_0100007 BIS-TRIS http://www.bioassayontology.org/bao#BAO_0003043 molecular entity Bis-tris methane Common buffering agent http://www.bioassayontology.org/bao#BAO_0100008 DAPI http://purl.obolibrary.org/obo/CHEBI_51121 fluorescent dye 4',6-diamidino-2-phenylindole Blue-fluorescent DNA stain http://www.bioassayontology.org/bao#BAO_0100009 formamide http://www.bioassayontology.org/bao#BAO_0003043 molecular entity methanamide Organic solvent which allows for the denaturation and renaturation of nucleic acids at room temperature. Often used as a quenching agent. http://www.bioassayontology.org/bao#BAO_0100010 magnesium chloride http://www.bioassayontology.org/bao#BAO_0003043 molecular entity chloromagnestite Hygroscopic salt commonly used in buffers http://www.bioassayontology.org/bao#BAO_0100011 potassium chloride http://www.bioassayontology.org/bao#BAO_0003043 molecular entity KCl Inorganic salt commonly used in buffers http://www.bioassayontology.org/bao#BAO_0100012 sodium chloride http://www.bioassayontology.org/bao#BAO_0003043 molecular entity NaCl Commonly used salt http://www.bioassayontology.org/bao#BAO_0150096 Luminex 200 Flow Cytometer http://www.bioassayontology.org/bao#BAO_0000697 detection instrument The Luminex 200 system is a compact analyzer that performs up to 100 immunoassays simultaneously using a single drop of fluid. http://www.bioassayontology.org/bao#BAO_0150097 FlexStation III Microplate Reader http://www.bioassayontology.org/bao#BAO_0000697 detection instrument FlexStation 3 The FlexStation 3 Multi-Mode Microplate Reader measures absorbance, fluorescence intensity, fluorescence polarization, luminescence, and time-resolved fluorescence for biochemical and cell-based assays. The reader adds up to three transfers of assay reagents from a 96- or 384-well source plate to enhance assay design using integrated fluidics. http://www.bioassayontology.org/bao#BAO_0150098 IN Cell Analyzer 2500 http://www.bioassayontology.org/bao#BAO_0000697 detection instrument IN Cell Analyzer 2500HS is a widefield high-content imaging system equipped with deconvolution. http://www.bioassayontology.org/bao#BAO_0150099 IN Cell Analyzer 6500 http://www.bioassayontology.org/bao#BAO_0000697 detection instrument IN Cell Analyzer 6500HS is a laser-based high-content imaging system featuring IRIS confocal technology. http://www.bioassayontology.org/bao#BAO_0000590 DNA-RNA interaction assay http://www.bioassayontology.org/bao#BAO_0002989 binding assay deoxyribonucleic acid-ribonucleic acid DNA-RNA interaction http://www.bioassayontology.org/bao#BAO_0000346 50 percent activation http://www.bioassayontology.org/bao#BAO_0000200 percent activation 50% activation 50% increase of a predefined stimulus. Unit of Measure is always % when normalized to the dynamic range of the assay. http://www.bioassayontology.org/bao#BAO_0002120 AUC http://www.bioassayontology.org/bao#BAO_0002118 graphical calculation endpoint area under curve It is the area under the drug concentration-time curve (AUC) following a single dose or at steady state, and is expressed as weight*time/volume. http://www.bioassayontology.org/bao#BAO_0000005 flow cytometry http://www.bioassayontology.org/bao#BAO_0000046 fluorescence method Fluorescence-activated cell sorting Flow cytometry uses the principles of light scattering and fluorescence from fluorochrome molecules to generate specific multi-parameter data from particles and cells in the size range of 0.5um to 40um diameter. http://www.bioassayontology.org/bao#BAO_0000134 ELISA http://www.bioassayontology.org/bao#BAO_0000466 ex situ immunoassay enzyme-linked immunosorbent assay Enzyme linked immunosorbent assay or ELISA is used to detect the presence of a particular protein, either an antigen or antibody in the sample such as a body fluid. http://www.bioassayontology.org/bao#BAO_0000164 ATP quantitation http://www.bioassayontology.org/bao#BAO_0000127 viability measurement method adenosine triphosphate content ATP levels are an indicator of viable cell number. ATP values higher than controls (untreated cells) indicate proliferation and cultures with ATP concentrations lower than controls indicate cytotoxicity. ATP levels can be measured using different commercial kits. http://www.bioassayontology.org/bao#BAO_0000392 generic membrane protein http://www.bioassayontology.org/bao#BAO_0000367 membrane protein This class includes membrane proteins other than g-proteins, such as regulators of g-protein, GTPases, etc. http://www.bioassayontology.org/bao#BAO_0002247 JAligner sequence alignment http://www.bioassayontology.org/bao#BAO_0002246 pairwise sequence alignment is an open source Java implementation of the Smith-Waterman algorithm with Gotoh's improvement for biological local pairwise sequence alignment using the affine gap penalty model. http://www.bioassayontology.org/bao#BAO_0000368 G protein http://www.bioassayontology.org/bao#BAO_0000367 membrane protein There are two distinct G protein families, namely the heterotrimeric G proteins (consisting of the α, β and γ subunits) downstream of the G protein coupled receptors (GPCRs) and the monomeric G proteins that belong to the Ras superfamily of GTPases. Upon ligand binding, the GPCR undergoes a conformational change, which allows it to act as a guanine nucleotide exchange factor (GEF) of an associated G protein. The GTP-bound G α subunit then signals by regulating the activity of adenylate cyclase, phospholipase, or Rho GEFs. http://www.bioassayontology.org/bao#BAO_0002480 vital dye staining http://www.bioassayontology.org/bao#BAO_0002452 labeling method Method that employs a stain that is capable of entering and staining a living cell without causing an injury. http://www.bioassayontology.org/bao#BAO_0000928 GM-TriDAP peptide http://www.bioassayontology.org/bao#BAO_0000325 peptide GM-TriDAP (GlcNAc-MurNAc-L-Ala-D-Glu-mesoDAP), is a muropeptide found mostly in Gram-negative bacterial peptidoglycan. http://www.bioassayontology.org/bao#BAO_0002051 DNA vector http://www.bioassayontology.org/bao#BAO_0003111 biological macromolecule The plasmid, phagemid or viral genome that is used to recombinantly clone the DNA molecule of interest to be introduced into a host cell (bacterial, eukaryotic), where it can independently replicate. http://www.bioassayontology.org/bao#BAO_0002457 MTT reduction assay http://www.bioassayontology.org/bao#BAO_0002455 colorimetric cell staining method The MTT assay is a colorimetric assay that relies on the enzymatic reduction of a yellow tetrazolium salt, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT), which forms a purple formazan crystal in metabolically active cells. The formazan can then be solubilized producing a concentration dependent colorimetric signal at 570 nm proportional to the cell number and activity. http://www.bioassayontology.org/bao#BAO_0002887 ECMax_percent inhibition http://www.bioassayontology.org/bao#BAO_0002883 ECMax The compound concentration whereupon perceived activity (percent inhibition) reaches the maximum value observed (with a positive control). http://purl.obolibrary.org/obo/DOID_0080364 malignant adenoma http://purl.obolibrary.org/obo/DOID_0050687 cell type cancer A cell type cancer that is composed_of epithelial tissue in which tumor cells form glands or glandlike structures, representing an early form of colorectal cancer. http://purl.obolibrary.org/obo/DOID_0080377 peroxisomal biogenesis disorder http://purl.obolibrary.org/obo/DOID_906 peroxisomal disease A peroxisomal biogenesis disorder that has_material_basis_in defects in PEX genes. http://purl.obolibrary.org/obo/DOID_0080422 Dravet syndrome http://purl.obolibrary.org/obo/DOID_0050709 early infantile epileptic encephalopathy An early infantile epileptic encephalopathy that has_material_basis_in heterozygous mutation in the SCN1A gene on chromosome 2q24. http://purl.obolibrary.org/obo/DOID_0080488 mucolipidosis http://purl.obolibrary.org/obo/DOID_9455 lipid storage disease A lipid storage disease that is characterized by increased storage of carbohydrates and lipids. http://purl.obolibrary.org/obo/UO_0000058 rotational frequency unit http://purl.obolibrary.org/obo/UO_0000105 frequency unit A unit which is a standard measure of the number of rotations in a given time. http://purl.obolibrary.org/obo/UO_0000073 femtomolar http://purl.obolibrary.org/obo/UO_0000061 unit of molarity A unit of molarity which is equal to 10^[-15] M. http://purl.obolibrary.org/obo/UO_0000092 turns per second http://purl.obolibrary.org/obo/UO_0000058 rotational frequency unit A rotational frequency unit which is equal to the number complete turn in a period of time that equals to 1 second. http://purl.obolibrary.org/obo/UO_0000180 mass per unit volume http://purl.obolibrary.org/obo/UO_0000051 concentration unit A concentration unit which is a standard measure of the mass of a substance in a given volume (density). http://purl.obolibrary.org/obo/UO_0000200 cell concentration unit http://purl.obolibrary.org/obo/UO_0000051 concentration unit A concentration unit which denotes the average cell number in a given volume. http://purl.obolibrary.org/obo/UO_0000201 cells per milliliter http://purl.obolibrary.org/obo/UO_0000200 cell concentration unit A unit of cell concentration which is equal to one cell in a volume of 1 milliliter. http://purl.obolibrary.org/obo/UO_0000202 catalytic (activity) concentration unit http://purl.obolibrary.org/obo/UO_0000051 concentration unit A concentration unit which is a standard measure of the amount of the action of a catalyst in a given volume. http://purl.obolibrary.org/obo/UO_0000203 katal per cubic meter http://purl.obolibrary.org/obo/UO_0000202 catalytic (activity) concentration unit A catalytic (activity) concentration unit which is equal to 1 katal activity of a catalyst in a given volume of one cubic meter. http://purl.obolibrary.org/obo/UO_0000204 katal per liter http://purl.obolibrary.org/obo/UO_0000202 catalytic (activity) concentration unit A catalytic (activity) concentration unit which is equal to 1 katal activity of a catalyst in a given volume of one thousandth of a cubic meter. http://purl.obolibrary.org/obo/UO_0000316 cells per microliter http://purl.obolibrary.org/obo/UO_0000200 cell concentration unit A unit of cell concentration which is equal to one cell in a volume of 1 microliter. http://purl.obolibrary.org/obo/UO_0000317 cells per well http://purl.obolibrary.org/obo/UO_0000200 cell concentration unit A unit of cell concentration which is equal to 1 cell in a well or discrete container of arbitrary volume. http://www.bioassayontology.org/bao#BAO_0000577 vial http://www.bioassayontology.org/bao#BAO_0000512 assay footprint Vials are small containers that are used in biological measurements, including scintillation counting. http://www.bioassayontology.org/bao#BAO_0000407 multi parameter readout http://www.bioassayontology.org/bao#BAO_0002185 measure group specification This is typically performed in HCS, where multiple parameters are measured simultaneously from a single cell / well, by the detection of several fluorescent labels. E.g., neurite length, nuclear size, protein translocation, etc. http://www.bioassayontology.org/bao#BAO_0003036 ED50 http://www.bioassayontology.org/bao#BAO_0002116 dosage endpoint It is the dose that produces an effect in 50% of the tested population, or the dose required to produce half-maximal response. http://www.bioassayontology.org/bao#BAO_0002879 AC26 absolute http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint The compound concentration at which the fitted curve passes activity threshold 26. http://www.bioassayontology.org/bao#BAO_0000643 mutated http://www.bioassayontology.org/bao#BAO_0000013 primary structure Mutation is any alteration in a gene, which may be disease causing or a normal variant. Mutations are introduced into the genes and subsequently, introduced into cells for expression. Different types of mutations include missense, nonsense, deletions, insertions, etc. http://www.bioassayontology.org/bao#BAO_0002454 volumetric titration http://www.bioassayontology.org/bao#BAO_0002413 titration method Method in which the amount of a substance is determined by measuring the volume of a second substance that combines or reacts with the first in known proportions. http://www.bioassayontology.org/bao#BAO_0002883 ECMax http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint The compound concentration whereupon perceived activity reaches the maximum value observed (with a positive control). http://purl.obolibrary.org/obo/DOID_0080615 nephroma http://purl.obolibrary.org/obo/DOID_3116 kidney benign neoplasm A kidney benign neoplasm that is located_in the kidney cortex. http://purl.obolibrary.org/obo/DOID_0080616 kidney cortex disease http://purl.obolibrary.org/obo/DOID_557 kidney disease A kidney disease that is located_in the kidney cortex. http://purl.obolibrary.org/obo/DOID_0080619 auditory system benign neoplasm http://purl.obolibrary.org/obo/DOID_2742 auditory system disease A sensory system benign neoplasm that is located in the auditory system. http://purl.obolibrary.org/obo/DOID_0080639 bone sarcoma http://purl.obolibrary.org/obo/DOID_184 bone cancer A bone cancer that has_material_basis_in abnormally proliferating cells derives from embryonic mesoderm. http://purl.obolibrary.org/obo/UBERON_0000310 breast http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity The upper ventral region of the torso of an organism. http://purl.obolibrary.org/obo/PATO_0000014 color http://purl.obolibrary.org/obo/PATO_0001300 optical quality A composite chromatic quality composed of hue, saturation and intensity parts. http://purl.obolibrary.org/obo/PATO_0000049 intensity http://purl.obolibrary.org/obo/PATO_0001018 physical quality A quality inhering in a bearer by virtue of the bearer's possessing or displaying a distinctive feature in type or degree or effect or force. http://purl.obolibrary.org/obo/PATO_0000051 morphology http://www.bioassayontology.org/bao#BAO_0002928 quality A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure. http://purl.obolibrary.org/obo/PATO_0000052 shape http://purl.obolibrary.org/obo/PATO_0000051 morphology A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc). http://purl.obolibrary.org/obo/PATO_0000060 spatial pattern http://purl.obolibrary.org/obo/PATO_0002182 molecular quality A spatial quality inhering in a bearer by virtue of the bearer's exhibiting repetition of placement of its parts. http://purl.obolibrary.org/obo/PATO_0000117 size http://purl.obolibrary.org/obo/PATO_0000051 morphology A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude. http://purl.obolibrary.org/obo/PATO_0000141 structure http://purl.obolibrary.org/obo/PATO_0000051 morphology A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form. http://purl.obolibrary.org/obo/PATO_0000150 texture http://purl.obolibrary.org/obo/PATO_0000051 morphology A morphologic quality inhering in a bearer by virtue of the bearer's relative size, organization and distribution of its surface elements or the representation or invention of the appearance of its surface; visual and tactile surface characteristics. http://purl.obolibrary.org/obo/PATO_0000165 time http://purl.obolibrary.org/obo/PATO_0001018 physical quality A quality in which events occur in sequence. http://purl.obolibrary.org/obo/PATO_0000402 branched http://purl.obolibrary.org/obo/PATO_0000052 shape A branchiness quality inhering in a bearer by virtue of the bearer's having branches. http://purl.obolibrary.org/obo/PATO_0000411 circular http://purl.obolibrary.org/obo/PATO_0000052 shape A shape quality inhering in a bearer by virtue of the bearer's being such that every part of the surface or the circumference is equidistant from the center. http://purl.obolibrary.org/obo/PATO_0000462 absent http://purl.obolibrary.org/obo/PATO_0000068 qualitative A quality denoting the lack of an entity. http://purl.obolibrary.org/obo/PATO_0000467 present http://purl.obolibrary.org/obo/PATO_0000068 qualitative A quality inhering in a bearer by virtue of the bearer's existence. http://purl.obolibrary.org/obo/PATO_0000573 increased length http://purl.obolibrary.org/obo/PATO_0000122 length A length quality which is relatively large. http://purl.obolibrary.org/obo/PATO_0000574 decreased length http://purl.obolibrary.org/obo/PATO_0000122 length A length quality which is relatively small. http://purl.obolibrary.org/obo/PATO_0000585 hypotrophic http://purl.obolibrary.org/obo/PATO_0000918 volume A decreased size quality inhering in a bearer by virtue of the bearer's exhibiting reduced size of a cell or constituent group of cells (for example, organ). http://purl.obolibrary.org/obo/PATO_0000599 decreased width http://purl.obolibrary.org/obo/PATO_0000921 width A width which is relatively small. http://purl.obolibrary.org/obo/PATO_0000600 increased width http://purl.obolibrary.org/obo/PATO_0000921 width A width which is relatively large. http://purl.obolibrary.org/obo/PATO_0000627 localized http://purl.obolibrary.org/obo/PATO_0000060 spatial pattern A spatial pattern quality inhering in a bearer by virtue of the bearer's being confined or restricted to a particular location. http://purl.obolibrary.org/obo/PATO_0000638 apoptotic http://purl.obolibrary.org/obo/PATO_0000141 structure A structural quality inhering in a bearer by virtue of the bearer's consisting of blebbing of the nucleus and DNA fragmentation due to the cell undergoing a specific form of programmed cell death termed apoptosis. http://purl.obolibrary.org/obo/PATO_0000921 width http://purl.obolibrary.org/obo/PATO_0001708 1-D extent A 1-D extent quality which is equal to the distance from one side of an object to another side which is opposite. http://purl.obolibrary.org/obo/PATO_0000982 permeable http://purl.obolibrary.org/obo/PATO_0000141 structure A permeability quality inhering in a bearer by virtue of the bearer's being capable to be permeated or pervaded by a gas or liquid (as by osmosis or diffusion). http://purl.obolibrary.org/obo/PATO_0001018 physical quality http://www.bioassayontology.org/bao#BAO_0002928 quality A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities. http://purl.obolibrary.org/obo/PATO_0001154 elongated http://purl.obolibrary.org/obo/PATO_0000052 shape A quality inhering in a bearer by virtue of the bearer's length being notably higher than its width. http://purl.obolibrary.org/obo/PATO_0001300 optical quality http://purl.obolibrary.org/obo/PATO_0001018 physical quality An EM radiation quality in which the EM radiation is within the fiat range of the spectrum visible deemed to be light. http://purl.obolibrary.org/obo/PATO_0001323 area http://purl.obolibrary.org/obo/PATO_0001709 2-D extent A 2-D extent quality inhering in a bearer by virtue of the bearer's two dimensional extent. http://purl.obolibrary.org/obo/PATO_0001334 diameter http://purl.obolibrary.org/obo/PATO_0001708 1-D extent A length quality which is equal to the length of any straight line segment that passes through the center of a circle and whose endpoints are on the circular boundary. http://purl.obolibrary.org/obo/PATO_0001485 condensed http://purl.obolibrary.org/obo/PATO_0000141 structure A structural quality inhering in a bearer by virtue of the bearer's being thicker or more closely packed together; pressed tightly together. http://purl.obolibrary.org/obo/PATO_0001509 functionality http://purl.obolibrary.org/obo/PATO_0002182 molecular quality A quality of a single physical entity that arises by virtue of whether the bearer exhibits the ability to perform a regular function(s). http://purl.obolibrary.org/obo/PATO_0001516 focus http://purl.obolibrary.org/obo/PATO_0001300 optical quality An optical quality where light rays originating from a point on the object converge. http://purl.obolibrary.org/obo/PATO_0001518 blurry http://purl.obolibrary.org/obo/PATO_0000049 intensity An optical quality inhering in a bearer by virtue of the bearer's lacking focus. http://purl.obolibrary.org/obo/PATO_0001566 distributed http://purl.obolibrary.org/obo/PATO_0000060 spatial pattern A spatial pattern inhering in a bearer by virtue of the bearer's being spread out or scattered about or divided up. http://purl.obolibrary.org/obo/PATO_0001629 aggregated http://purl.obolibrary.org/obo/PATO_0000060 spatial pattern A spatial pattern inhering in a bearer by virtue of the bearer's being gathered or tending to gather into a mass or whole. http://purl.obolibrary.org/obo/PATO_0001708 1-D extent http://purl.obolibrary.org/obo/PATO_0000117 size A size quality inhering in an bearer by virtue of the bearer's extension in one dimension. http://purl.obolibrary.org/obo/PATO_0001709 2-D extent http://purl.obolibrary.org/obo/PATO_0000117 size A size quality inhering in an bearer by virtue of the bearer's extension in two dimensions. http://purl.obolibrary.org/obo/PATO_0001710 3-D extent http://purl.obolibrary.org/obo/PATO_0000117 size A size quality inhering in an bearer by virtue of the bearer's extension in three dimensions. http://purl.obolibrary.org/obo/PATO_0001782 increased intensity http://purl.obolibrary.org/obo/PATO_0000049 intensity An intensity which is relatively high. http://purl.obolibrary.org/obo/PATO_0001783 decreased intensity http://purl.obolibrary.org/obo/PATO_0000049 intensity An intensity which is relatively low. http://purl.obolibrary.org/obo/PATO_0001791 multi-localised http://purl.obolibrary.org/obo/PATO_0000060 spatial pattern A spatial pattern inhering in a bearer by virtue of the bearer's being confined or restricted to multiple locations. http://purl.obolibrary.org/obo/PATO_0001861 fasciculated http://purl.obolibrary.org/obo/PATO_0000141 structure A structural quality inhering in a bearer by virtue of the bearer's forming a bundle of aligned anatomical fibers, as of muscle or nerve. http://purl.obolibrary.org/obo/PATO_0001928 blistered http://purl.obolibrary.org/obo/PATO_0000150 texture A texture quality inhering in a bearer by virtue of a local accumulation of fluid underneath the surface of the bearer. http://purl.obolibrary.org/obo/PATO_0001959 defasciculated http://purl.obolibrary.org/obo/PATO_0000141 structure A structural quality inhering in a bearer by virtue of the bearer's in which bundles of aligned anatomical fibers have become separated. http://purl.obolibrary.org/obo/PATO_0002065 star shaped http://purl.obolibrary.org/obo/PATO_0000052 shape A shape quality inhering in a bearer by virtue of the bearer's being arranged like rays or radii; radiating from a common center. http://purl.obolibrary.org/obo/PATO_0002182 molecular quality http://www.bioassayontology.org/bao#BAO_0002928 quality A quality which inheres in a molecular entity, a single molecule, atom, ion, radical etc. http://purl.obolibrary.org/obo/PATO_0002220 phosphorylated http://www.bioassayontology.org/bao#BAO_0000672 posttranslationally modified A quality inhering in a protein or a molecule by virtue of the bearer's having a phosphate (PO4) group. http://purl.obolibrary.org/obo/PATO_0002263 dephosphorylated http://www.bioassayontology.org/bao#BAO_0000672 posttranslationally modified A quality inhering in a protein or a molecule by virtue of the bearer's lacking a phosphate (PO4) group. http://purl.obolibrary.org/obo/PATO_0002354 active http://purl.obolibrary.org/obo/PATO_0001509 functionality A quality of an physical object that is currently realizing one of its functions. http://purl.obolibrary.org/obo/PATO_0002355 inactive http://purl.obolibrary.org/obo/PATO_0001509 functionality A quality of a physical object that is currently realizing none of its functions. http://purl.obolibrary.org/obo/PATO_0002364 shortened http://purl.obolibrary.org/obo/PATO_0000052 shape A quality inhering in a bearer by virtue of the bearer's length being notably lower than its width. http://www.bioassayontology.org/bao#BAO_0000424 electrophysiological method http://www.bioassayontology.org/bao#BAO_0000377 membrane potential measurement method Electrically active cells, such as neurons, muscle and endocrine cells undergo changes in membrane potential due to depolarization and hyperpolarization as a result of opening and closing of ion channels. The electrical recordings from these cells are obtained by the insertion or attaching microelectrodes to these cells. Patch clamp, voltage clamp and current clamp are three ways of studying the current-voltage relationships of these ion channels. http://purl.obolibrary.org/obo/NCIT_C101294 Whole Genome Sequencing http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics A procedure that can determine the DNA sequence for nearly the entire genome of an individual. http://purl.obolibrary.org/obo/NCIT_C134270 Potency Assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics The determination of the strength of a material, as measured by the ability to produce a specific response. The potency of a pharmacologic substance is measured by the amount needed to produce a certain effect. http://purl.obolibrary.org/obo/DOID_0080638 B-cell acute lymphoblastic leukemia http://purl.obolibrary.org/obo/DOID_9952 acute lymphoblastic leukemia An acute lymphocytic leukemia characterized by too many B-cell lymphoblasts (immature white blood cells) in the bone marrow and blood. http://www.bioassayontology.org/bao#BAO_0080002 IC25 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint The effective concentration of an inhibitor, which produces 25% of the maximum possible response for that inhibitor. http://purl.obolibrary.org/obo/DOID_9255 frontotemporal dementia http://purl.obolibrary.org/obo/DOID_936 brain disease A dementia characterized by progressive neuronal loss predominantly involving the frontal and/or temporal lobes of the brain resulting in a gradual and progressive decline in behavior or language. http://purl.obolibrary.org/obo/DOID_1754 mitral valve stenosis http://purl.obolibrary.org/obo/DOID_61 mitral valve disease A mitral valve disease that is characterized by the narrowing of the orifice of the mitral valve of the heart. http://purl.obolibrary.org/obo/DOID_1785 pituitary cancer http://purl.obolibrary.org/obo/DOID_53 pituitary gland disease An endocrine gland cancer located_in the pituitary gland located at the base of the brain. http://purl.obolibrary.org/obo/DOID_1788 peritoneal mesothelioma http://purl.obolibrary.org/obo/DOID_1749 squamous cell carcinoma A peritoneum cancer that develops from cells of the mesothelium and is located_in the peritoneum. http://purl.obolibrary.org/obo/DOID_1790 malignant mesothelioma http://purl.obolibrary.org/obo/DOID_0050687 cell type cancer A cell type cancer that has_material_basis_in mesothelial tissue that develops from the thin layer of tissue that covers many of the internal organs. http://purl.obolibrary.org/obo/DOID_1791 peritoneal carcinoma http://purl.obolibrary.org/obo/DOID_3119 gastrointestinal system cancer A carcinoma that is located_in the inside of the abdomen. http://purl.obolibrary.org/obo/DOID_1793 pancreatic cancer http://purl.obolibrary.org/obo/DOID_26 pancreas disease An endocrine gland cancer located_in the pancreas. http://purl.obolibrary.org/obo/DOID_1795 malignant exocrine pancreas neoplasm http://purl.obolibrary.org/obo/DOID_1793 pancreatic cancer A pancreatic cancer that arises from the epithelial cells of the exocrine pancreatic tissue. http://purl.obolibrary.org/obo/DOID_1798 pancreatic endocrine carcinoma http://purl.obolibrary.org/obo/DOID_1799 islet cell tumor An islet cell tumor that has_material_basis_in epithelial cells. http://purl.obolibrary.org/obo/DOID_1799 islet cell tumor http://purl.obolibrary.org/obo/DOID_1793 pancreatic cancer A pancreatic cancer that is located_in the pancreatic islet cells. http://purl.obolibrary.org/obo/DOID_180 ossifying fibroma http://purl.obolibrary.org/obo/DOID_0060094 bone benign neoplasm A bone benign neoplasm that is located_in the mouth and results_in an overgrowth of gingival tissue due to irritation or trauma. http://purl.obolibrary.org/obo/DOID_1800 neuroendocrine carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A carcinoma that derives_from neuroendocrine cells. http://purl.obolibrary.org/obo/DOID_1825 childhood absence epilepsy http://purl.obolibrary.org/obo/DOID_0050704 childhood electroclinical syndrome A childhood electroclinical syndrome that is characterized by brief and frequent absence seizures in children with age of onset between four and ten years. http://purl.obolibrary.org/obo/DOID_1849 cannabis dependence http://purl.obolibrary.org/obo/DOID_9977 hallucinogen dependence A drug dependence that involves the continued use of cannabis despite problems related to use of the substance. http://purl.obolibrary.org/obo/DOID_1852 intrahepatic cholestasis http://purl.obolibrary.org/obo/DOID_13580 cholestasis A cholestasis characterized by impairment of the bile flow caused by obstruction located_in liver. http://purl.obolibrary.org/obo/DOID_1856 cherubism http://purl.obolibrary.org/obo/DOID_37 skin disease A bone disease characterized by replacement of bone in the jaws with fibrous tissue leding to facial swelling that has_material_basis_in heterozygous mutation in SH3BP2 on chromosome 4p16.3. http://purl.obolibrary.org/obo/DOID_1858 McCune Albright syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by polyostotic fibrous dysplasia, precocious puberty, and café-au-lait spots and has_material_basis_in spontaneous post zygotic missense mutation at ARG201 or Gln227 of the GNAS gene during embryogenesis. http://purl.obolibrary.org/obo/DOID_1862 jaw cancer http://purl.obolibrary.org/obo/DOID_184 bone cancer A bone cancer and jaw disease that is located in the jaw and results in a swollen jaw, results in numbness or a tingling sensation in jaw, and results in an abnormal growth of the jaw bone. http://purl.obolibrary.org/obo/DOID_1883 hepatitis C http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis C virus, which is transmitted_by blood from an infected person enters the body of an uninfected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice. http://purl.obolibrary.org/obo/DOID_1911 endodermal sinus tumor http://purl.obolibrary.org/obo/DOID_2994 germ cell cancer A germ cell cancer that has_material_basis_in cells that line the yolk sac of the embryo. http://purl.obolibrary.org/obo/DOID_1920 hyperuricemia http://purl.obolibrary.org/obo/DOID_0060158 acquired metabolic disease An acquired metabolic disease that has_material_basis_in an abnormally high level of uric acid in the blood. http://purl.obolibrary.org/obo/DOID_1921 Klinefelter syndrome http://purl.obolibrary.org/obo/DOID_0060429 chromosomal duplication syndrome A chromosomal duplication syndrome that is characterized by infertility and that has_material_basis_in an extra X chromosome in cells in men. http://purl.obolibrary.org/obo/DOID_1925 Coffin-Siris syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome An autosomal dominant non-syndromic intellectual disability that is characterized by mental retardation associated with coarse facial features, hypertrichosis, sparse scalp hair, and hypoplastic or absent fifth fingernails or toenails. http://purl.obolibrary.org/obo/DOID_1926 Gaucher's disease http://purl.obolibrary.org/obo/DOID_1927 sphingolipidosis A sphingolipidosis characterized by deficiency of the enzyme glucocerebrosidase which results in the accumulation of harmful quantities of the glycolipid glucocerebroside throughout the body, especially within the bone marrow, spleen and liver. http://purl.obolibrary.org/obo/DOID_1928 Williams-Beuren syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by mild to moderate intellectual disability, a broad forehead, a short nose with a broad tip, full cheeks, and a wide mouth with full lips and difficulty with visual-spatial tasks and has_material_basis_in hemizygous deletion of 1.5 to 1.8 Mb on chromosome 7q11.23. http://purl.obolibrary.org/obo/DOID_1929 supravalvular aortic stenosis http://purl.obolibrary.org/obo/DOID_1712 aortic valve stenosis An aortic valve stenosis that is characterized by a narrowing of the section of the aorta just above the valve that connects the aorta to the heart. http://purl.obolibrary.org/obo/DOID_1930 Laurence-Moon syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by pituitary dysfunction, childhood onset ataxia, peripheral neuropathy, spastic paraplegia, and chorioretinopathy that has_material_basis_in homozygous or compound heterozygous mutation in PNPLA6 on chromosome 19p13.2. http://purl.obolibrary.org/obo/DOID_1932 Angelman syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by delayed development, intellectual disability, severe speech impairment, and problems with movement and balance. http://purl.obolibrary.org/obo/DOID_1933 Rubinstein-Taybi syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by short stature, moderate to sever intellectual disability, distinctive facial features and broad thumbs and first toes. http://purl.obolibrary.org/obo/DOID_1947 trichomoniasis http://purl.obolibrary.org/obo/DOID_2789 parasitic protozoa infectious disease A parasitic protozoa infectious disease that is caused by singled-celled protozoan parasites Trichomonas vaginalis or Trichomonas tenax, which infect the urogenital tract and mouth respectively. http://purl.obolibrary.org/obo/DOID_1949 cholecystitis http://purl.obolibrary.org/obo/DOID_9446 cholangitis A cholangitis that is characterized by an inflammation that is located in the gallbladder. http://purl.obolibrary.org/obo/DOID_1963 fallopian tube carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A fallopian tube cancer that is located_in the fallopian tube. http://purl.obolibrary.org/obo/DOID_1964 fallopian tube cancer http://purl.obolibrary.org/obo/DOID_1962 fallopian tube disease A female reproductive organ cancer that is located_in fallopian tube. http://purl.obolibrary.org/obo/DOID_1967 leiomyosarcoma http://purl.obolibrary.org/obo/DOID_4230 smooth muscle cancer A smooth muscle cancer that can arise almost anywhere in the body, but is most common in the uterus, abdomen, or pelvis. http://purl.obolibrary.org/obo/DOID_1974 adenosarcoma http://purl.obolibrary.org/obo/DOID_4236 carcinosarcoma A carcinosarcoma that derives_from simultaneously or consecutively in mesodermal tissue and glandular epithelium. http://purl.obolibrary.org/obo/DOID_1993 rectum cancer http://purl.obolibrary.org/obo/DOID_9256 colorectal cancer A colorectal cancer that is located_in the rectum. http://purl.obolibrary.org/obo/DOID_1996 rectum adenocarcinoma http://purl.obolibrary.org/obo/DOID_299 adenocarcinoma A rectum cancer that derives_from epithelial cells of glandular origin. http://purl.obolibrary.org/obo/DOID_2001 neuroma http://purl.obolibrary.org/obo/DOID_0060115 nervous system benign neoplasm A nervous system benign neoplasm that is characterized as a nerve tissue tumor. http://purl.obolibrary.org/obo/DOID_2012 Nezelof syndrome http://purl.obolibrary.org/obo/DOID_11200 T cell deficiency A T cell deficiency that results from the disfunction or underdevelopment of the thymus. http://purl.obolibrary.org/obo/DOID_2021 placenta cancer http://purl.obolibrary.org/obo/DOID_780 placenta disease A female reproductive organ cancer that is located_in the placenta. http://purl.obolibrary.org/obo/DOID_2025 gestational choriocarcinoma http://purl.obolibrary.org/obo/DOID_3594 choriocarcinoma A choriocarcicoma that develops in the presence of a preceding gestational event. http://purl.obolibrary.org/obo/DOID_203 exostosis http://purl.obolibrary.org/obo/DOID_205 hyperostosis A hyperostosis that involves formation of new bone on the surface of preexisting bone. http://purl.obolibrary.org/obo/DOID_2043 hepatitis B http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis B virus, which is transmitted_by sexual contact, transmitted_by blood transfusions, and transmitted_by fomites like needles or syringes. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice. http://purl.obolibrary.org/obo/DOID_2047 hepatitis D http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis delta virus, which is an incomplete virus that requires the helper function of Hepatitis B virus to replicate and only occurs among people who are infected with the Hepatitis B virus. The infection has_symptom fatigue, has_symptom lethargy, has_symptom anorexia, has_symptom nausea, has_symptom jaundice, has_symptom clay-colored stools, has_symptom dark urine, has_symptom changes in personality, has_symptom disturbances in sleep, has_symptom confusion, has_symptom abnormal behavior, has_symptom somnolence, and has_symptom coma. http://purl.obolibrary.org/obo/DOID_2048 autoimmune hepatitis http://purl.obolibrary.org/obo/DOID_0060031 autoimmune disease of gastrointestinal tract An autoimmune disease of gastrointestinal tract that results_in inflammation located_in liver caused by the body's immune system attacking the liver cells. http://purl.obolibrary.org/obo/DOID_2050 acute maxillary sinusitis http://purl.obolibrary.org/obo/DOID_2051 maxillary sinusitis A maxillary sinusitis which lasts for less than 4 weeks. http://purl.obolibrary.org/obo/DOID_2055 post-traumatic stress disorder http://purl.obolibrary.org/obo/DOID_2030 anxiety disorder An anxiety disorder which results from a traumatic experience that results in psychological trauma. http://purl.obolibrary.org/obo/DOID_2058 chronic mucocutaneous candidiasis http://purl.obolibrary.org/obo/DOID_4123 nail disease A candidiasis that refers to a heterogeneous group of disorders characterized by recurrent or persistent superficial fungal infections located_in skin, located_in mucous membrane, or located_in nail due to T-cell defects, has-agent Candida species and has_symptom scaling of skin lesions, has_symptom thickening of nails, has_symptom swollen periungal tissue, and has_symptom scarring of the scalp. http://purl.obolibrary.org/obo/DOID_2089 constipation http://purl.obolibrary.org/obo/DOID_9779 bowel dysfunction A bowel dysfunction that is characterized by infrequent or difficult evacuation of feces. http://purl.obolibrary.org/obo/DOID_2093 vulvar melanoma http://purl.obolibrary.org/obo/DOID_1245 vulva cancer A vulva cancer that has_material_basis in melanocytes. http://purl.obolibrary.org/obo/DOID_2097 vulval Paget's disease http://purl.obolibrary.org/obo/DOID_2098 vulva adenocarcinoma A vulva adenocarcinoma that is characterized by distinctive large cells with prominent cytoplasm, referred to as Paget cells and is an intraepithelial neoplasm of epithelial origin expressing apocrine or eccrine glandular-like features. http://purl.obolibrary.org/obo/DOID_2098 vulva adenocarcinoma http://purl.obolibrary.org/obo/DOID_299 adenocarcinoma A vulva carcinoma that derives_from epithelial cells of glandular origin. http://purl.obolibrary.org/obo/DOID_2106 myotonia congenita http://purl.obolibrary.org/obo/DOID_66 muscle tissue disease A muscle tissue disease that is characterised by slow muscle relaxation associated with hyperexcitation of the muscle fibres. http://purl.obolibrary.org/obo/DOID_2112 cystoisosporiasis http://purl.obolibrary.org/obo/DOID_2113 coccidiosis A coccidiosis that involves infection of the epithelial cells of the small intestine with Cystoisospora belli, which results in nonbloody diarrhea with crampy abdominal pain, malabsorption and weight loss. http://purl.obolibrary.org/obo/DOID_2120 focal dermal hypoplasia http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized at birth by streaks of very thin skin (dermal hypoplasia), cutis aplasia, and telangiectases, and has_material_basis_in heterozygous mutation in the PORCN gene on chromosome Xp11.23. http://purl.obolibrary.org/obo/DOID_2121 ectodermal dysplasia http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by abnormal development in 2 or more ectodermal structures (hair, nails, teeth, and sweat glands) without other systemic findings. http://purl.obolibrary.org/obo/DOID_2129 atypical teratoid rhabdoid tumor http://purl.obolibrary.org/obo/DOID_1319 brain cancer A brain cancer that is usually located in the brain, but can occur anywhere in the central nervous system. http://purl.obolibrary.org/obo/DOID_2151 malignant ovarian surface epithelial-stromal neoplasm http://purl.obolibrary.org/obo/DOID_2152 ovary epithelial cancer An ovary epithelial cancer that has_material_basis_in epithelial and stromal tissue and arises from the surface epithelium of the ovary. http://purl.obolibrary.org/obo/DOID_2152 ovary epithelial cancer http://purl.obolibrary.org/obo/DOID_305 carcinoma An ovarian cancer that is derives_from ovarian surface epithelium. http://purl.obolibrary.org/obo/DOID_2154 nephroblastoma http://purl.obolibrary.org/obo/DOID_263 kidney cancer A kidney cancer that affects the kidneys and typically located_in children. http://purl.obolibrary.org/obo/DOID_2156 ovarian germ cell cancer http://purl.obolibrary.org/obo/DOID_2394 ovarian cancer An ovarian cancer that originates in the germ (egg) cells of the ovary. http://purl.obolibrary.org/obo/DOID_2174 ocular cancer http://purl.obolibrary.org/obo/DOID_5614 eye disease A sensory system cancer located_in the eye that is characterized by uncontrolled cellular proliferation in the eye. http://purl.obolibrary.org/obo/DOID_2211 factor XIII deficiency http://purl.obolibrary.org/obo/DOID_1247 blood coagulation disease A blood coagulation disease that is characterized by easy bleeding, has_symptom prolonged umbilical cord bleeding, epistaxis, bleeding of the gums, menorrhagia, recurrent miscarriages, abnormal scar formation and wound healing, and hemarthrosis, and has_material_basis_in autosomal recessive inheritance of mutation of the F13A1 or F13B gene, which encodes Factor XIII, formally known as fibrin stabilizing factor. http://purl.obolibrary.org/obo/DOID_2215 factor VII deficiency http://purl.obolibrary.org/obo/DOID_1247 blood coagulation disease A blood coagulation disease that is characterized by easy bleeding, has_symptom epistaxis, bleeding of the gums, menorrhagia, and occasionally hemarthrosis, and has_material_basis_in autosomal recessive inheritance of mutation in the F7 gene, which encodes coagulation factor VII, an important factor in the clotting cascade. http://purl.obolibrary.org/obo/DOID_2217 Bernard-Soulier syndrome http://purl.obolibrary.org/obo/DOID_1247 blood coagulation disease A blood coagulation disease characterized by autosomal recessive inheritance of mucosal bleeding, purpuric skin bleeding, epistaxis, and menorrhagia with prolonged bleeding times, enlarged platelets and absence of platelet aggregation in response to von Willebrand factor that has material_basis_in mutation in the GP1BA gene, the GP1BB gene, or the GP9 gene which are subunits of the platelet membrane von Willebrand factor receptor complex, glycoprotein Ib. http://purl.obolibrary.org/obo/DOID_2219 Glanzmann's thrombasthenia http://purl.obolibrary.org/obo/DOID_2218 blood platelet disease A blood coagulation disease characterized by autosomal recessive inheritance of failure of platelet aggregation and absent or diminished clot retraction that has material_basis_in mutation in the ITGA2B or ITGB3 genes on chromosome 17q21.32. http://purl.obolibrary.org/obo/DOID_2222 factor X deficiency http://purl.obolibrary.org/obo/DOID_1247 blood coagulation disease A blood coagulation disease that is characterized by the partial or complete absence of factor X activity in the blood. http://purl.obolibrary.org/obo/DOID_2224 essential thrombocythemia http://purl.obolibrary.org/obo/DOID_2226 myeloproliferative neoplasm A myeloproliferative neoplasm that is characterized by sustained thrombocytosis in the blood, increased numbers of large, mature megakaryocytes in the bone marrow, and episodes of thrombosis and/or hemorrhage and that results_in the overproduction of platelets. http://purl.obolibrary.org/obo/DOID_2226 myeloproliferative neoplasm http://purl.obolibrary.org/obo/DOID_0070004 myeloid neoplasm A myeloid neoplasm that is characterized by a group of slow growing blood cancers in which large numbers of abnormal red blood cells, white blood cells, or platelets grow and spread in the bone marrow and the peripheral blood. http://purl.obolibrary.org/obo/DOID_2228 thrombocytosis http://purl.obolibrary.org/obo/DOID_2218 blood platelet disease A blood platelet disease that is characterized by the presence of high platelet counts in the blood. http://purl.obolibrary.org/obo/DOID_2229 factor XI deficiency http://purl.obolibrary.org/obo/DOID_1247 blood coagulation disease A blood coagulation disease that is characterized by deficiency of factor XI clotting factor and mild prolonged bleeding, especially of mucosal sites following trauma, and has_material_basis_in homozygous, compound heterozygous, or heterozygous mutation of the coagulation factor XI gene of chromosome 4q35.2. http://purl.obolibrary.org/obo/DOID_2231 factor XII deficiency http://purl.obolibrary.org/obo/DOID_1247 blood coagulation disease A blood coagulation disease that is characterized by prolonged PTT time without clinical symptoms, and has_material_basis_in a mutation in the F12 gene on chromosome 5q33. http://purl.obolibrary.org/obo/DOID_2236 congenital afibrinogenemia http://purl.obolibrary.org/obo/DOID_1247 blood coagulation disease A blood coagulation disease that is characterized by an impaired blood clotting resulting from a lack deficiency of a the fibrinogen protein (coagulation factor I). http://purl.obolibrary.org/obo/DOID_2247 spondylosis http://purl.obolibrary.org/obo/DOID_0080010 bone structure disease An bone structure disease that involves degeneration between vertebra located_in vertebral column. http://purl.obolibrary.org/obo/DOID_2272 vulvovaginal candidiasis http://purl.obolibrary.org/obo/DOID_1508 candidiasis A candidiasis that involves fungal infection of the vaginal mucous membranes in women caused by Candida albicans. The symptoms include intense vulval pruritus, burning, erythema and dyspareunia associated with a creamy white, curd-like discharge. http://purl.obolibrary.org/obo/DOID_2275 pharyngitis http://purl.obolibrary.org/obo/DOID_974 upper respiratory tract disease An upper respiratory tract disease involving inflammation of the throat or pharynx resulting from bacterial, viral, fungal infections or irritants like pollutants or chemical substances and smoking. The infection is often referred to as sore throat. The symptoms include pain during swallowing, enlarged tonsils coated with a white discharge, runny nose, cough and slight fever. http://purl.obolibrary.org/obo/DOID_2277 gonadal disease http://purl.obolibrary.org/obo/DOID_28 endocrine system disease An endocrine system disease that is located_in the gonads. http://purl.obolibrary.org/obo/DOID_2280 hidradenitis suppurativa http://purl.obolibrary.org/obo/DOID_2282 hidradenitis A hidradenitis that is characterized by chronic inflammation of the apocrine sweat glands, has_symptom painful nodules, abscesses, sinus tract formation, scarring, erythema, pruritis, and pain, and has_material_basis_in chronic inflammation of the apocrine sweat glands leading to recurrent folliculitis and an accompanying immune response that worsens inflammation. http://purl.obolibrary.org/obo/DOID_2282 hidradenitis http://purl.obolibrary.org/obo/DOID_1383 sweat gland disease A sweat gland disease that is characterized by inflammation of the apocrine sweat glands and has_symptom erythema, edema, papules, plaques, pruritis, and pain. http://purl.obolibrary.org/obo/DOID_2297 leptospirosis http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that involves systemic infection, has_material_basis_in Leptospira, which is transmitted by contact with water, food, or soil containing urine from the infected animals. The infection has symptom jaundice, has symptom chills, has symptom fever, has symptom muscle pain, and has symptom hepatomegaly. http://purl.obolibrary.org/obo/DOID_230 lateral sclerosis http://purl.obolibrary.org/obo/DOID_231 motor neuron disease A motor neuron disease characterized by painless but progressive weakness and stiffness of the muscles of the legs. http://purl.obolibrary.org/obo/DOID_2300 spondylolysis http://purl.obolibrary.org/obo/DOID_0080010 bone structure disease A bone structure disease that involves a defect located_in lumbar vertebral column. http://purl.obolibrary.org/obo/DOID_2303 stereotypic movement disorder http://purl.obolibrary.org/obo/DOID_0060038 specific developmental disorder A specific developmental disorder that is characterized by repeated, rhythmic, purposeless movements or activities such as head banging, nail biting, or body rocking. http://purl.obolibrary.org/obo/DOID_2312 nocardiosis http://purl.obolibrary.org/obo/DOID_0050340 opportunistic bacterial infectious disease An opportunistic bacterial infectious disease that results_in disseminated infection in immunocompromised hosts, has_material_basis_in Nocardia asteroides. The infection has_symptom pneumonia, has_symptom cellulitis, has_symptom lesions in the brain or meninges, and has_symptom ascending regional lymphadenopathy. http://purl.obolibrary.org/obo/DOID_2316 brain ischemia http://purl.obolibrary.org/obo/DOID_6713 cerebrovascular disease An ischemia that is characterized by insufficient blood flow to the brain to meet metabolic demand. http://purl.obolibrary.org/obo/DOID_2320 obstructive lung disease http://purl.obolibrary.org/obo/DOID_850 lung disease A lung disease that is characterized by narrowing of pulmonary airways. http://purl.obolibrary.org/obo/DOID_2326 gastroenteritis http://purl.obolibrary.org/obo/DOID_77 gastrointestinal system disease A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen. http://purl.obolibrary.org/obo/DOID_2338 mandibular cancer http://purl.obolibrary.org/obo/DOID_1862 jaw cancer A jaw cancer and mandibular disease that affects your lower jawbone. http://purl.obolibrary.org/obo/DOID_2352 hemochromatosis http://purl.obolibrary.org/obo/DOID_896 metal metabolism disorder A metal metabolism disorder characterized by the accumulation of iron in various organs of the body. http://purl.obolibrary.org/obo/DOID_2354 myelophthisic anemia http://purl.obolibrary.org/obo/DOID_12449 aplastic anemia An aplastic anemia that is characterized by displacement of hemopoietic bone-marrow tissue either by fibrosis, tumors or granulomas. http://purl.obolibrary.org/obo/DOID_2366 West Nile fever http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in infection, has_material_basis_in West Nile virus, which is transmitted_by Culex and transmitted_by Aedes mosquitoes. The infection has_symptom fever, has_symptom sore throat, has_symptom headache, has_symptom body ache, has_symptom nausea, has_symptom maculopapular rash and has_symptom vomiting. http://purl.obolibrary.org/obo/DOID_2368 gangliosidosis http://purl.obolibrary.org/obo/DOID_1927 sphingolipidosis A sphingolipidosis that is characterized by the accumulation of lipids known as gangliosides. http://purl.obolibrary.org/obo/DOID_2373 hereditary elliptocytosis http://purl.obolibrary.org/obo/DOID_74 hematopoietic system disease A hematopoietic system disease characterized by oval or elliptical red blood cells, slight or absent hemolysis with little or no anemia; splenomegaly is often present. http://purl.obolibrary.org/obo/DOID_2382 kernicterus http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is characterized by hyperbilirubinemia-induced brain dysfunction. http://purl.obolibrary.org/obo/DOID_2384 Wernicke encephalopathy http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is characterised by the presence of neurological symptoms of ophthalmoplegia, ataxia, and confusion caused by biochemical lesions of the central nervous system after exhaustion of B-vitamin reserves, in particular thiamine (vitamin B1). http://purl.obolibrary.org/obo/DOID_2426 gangliocytoma http://purl.obolibrary.org/obo/DOID_0060090 central nervous system benign neoplasm A central nervous system benign neoplasm that has_material_basis_in mature neurons, and is classified by the absence of neoplastic glial cells. http://purl.obolibrary.org/obo/DOID_2449 acromegaly http://purl.obolibrary.org/obo/DOID_2444 hyperpituitarism A disease of metabolism that has_material_basis_in excessive growth hormone production which results_in enlargement located_in limb. http://purl.obolibrary.org/obo/DOID_2479 central nervous system origin vertigo http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is characterized by vertigo caused by hemorrhagic insult, ischemic insult or mass lesion of the cerebellum, the vestibular nuclei, and the brainstem, has_symptom dizziness, has_symptom nausea, has_symptom vomiting and has_symptom difficulty walking. http://purl.obolibrary.org/obo/DOID_248 trachea leiomyoma http://purl.obolibrary.org/obo/DOID_3225 tracheal disease A respiratory system benign neoplasm that derives_from smooth muscle cells and is located_in the trachea. http://purl.obolibrary.org/obo/DOID_2491 sensory peripheral neuropathy http://purl.obolibrary.org/obo/DOID_870 neuropathy A neuropathy that involves damage to nerves of the peripheral nervous system. http://purl.obolibrary.org/obo/DOID_2508 Takayasu's arteritis http://purl.obolibrary.org/obo/DOID_865 vasculitis A vasculitis that involves inflammation of the aorta that carries blood from the heart to the rest of the body. http://purl.obolibrary.org/obo/DOID_2512 nevoid basal cell carcinoma syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by multiple early-onset basal cell carcinoma, multiple jaw keratocysts and skeletal abnormalities that has_material_basis_in heterozygous mutation in either PTCH1, PTCH2, or SUFU on chromosome 9q22, 1p32, or 10q24-q25, respectively. http://purl.obolibrary.org/obo/DOID_2513 basal cell carcinoma http://purl.obolibrary.org/obo/DOID_3451 skin carcinoma A skin carcinoma affecting basal cells. http://purl.obolibrary.org/obo/DOID_252 alcoholic psychosis http://purl.obolibrary.org/obo/DOID_251 alcohol-induced mental disorder An alcohol-induced mental disorder involving prominent hallucinations and delusions occurring during or shortly after acute alcohol intoxication or withdrawal. http://purl.obolibrary.org/obo/DOID_2544 extratemporal epilepsy http://purl.obolibrary.org/obo/DOID_1826 epilepsy An epilepsy syndrome that is located_in an area of the brain other than the temporal lobe. http://purl.obolibrary.org/obo/DOID_2556 relapsing polychondritis http://purl.obolibrary.org/obo/DOID_2557 chondromalacia A chondromalacia that is characterized by recurrent inflammation of cartilage and other tissues throughout the body. http://purl.obolibrary.org/obo/DOID_2559 opiate dependence http://purl.obolibrary.org/obo/DOID_9974 drug dependence A drug dependence that involves the continued use of opiate drugs despite despite problems related to use of the substance. http://purl.obolibrary.org/obo/DOID_2560 morphine dependence http://purl.obolibrary.org/obo/DOID_2559 opiate dependence An opiate dependence that involves the continued use of morphine despite despite problems related to use of the substance. http://purl.obolibrary.org/obo/DOID_2565 macular corneal dystrophy http://purl.obolibrary.org/obo/DOID_0060442 stromal dystrophy A corneal dystrophy that is characterized by corneal haze, bilateral loss of vision, eventually necessitating corneal transplantation resulting from progressive punctate opacities in the cornea. http://purl.obolibrary.org/obo/DOID_2571 Langerhans-cell histiocytosis http://purl.obolibrary.org/obo/DOID_3405 histiocytosis A histiocytosis that is characterized by clonal proliferation of Langerhans cells. http://purl.obolibrary.org/obo/DOID_2575 barbiturate dependence http://purl.obolibrary.org/obo/DOID_9974 drug dependence A drug dependence that involves the continued use of barbiturates despite problems related to use of the substance. http://purl.obolibrary.org/obo/DOID_2600 laryngeal carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A larynx cancer that has_material_basis_in epithelial cells. http://purl.obolibrary.org/obo/DOID_262 kidney hemangiopericytoma http://purl.obolibrary.org/obo/DOID_263 kidney cancer A kidney cancer which is manifested in the kidney. http://purl.obolibrary.org/obo/DOID_2621 autonomic nervous system neoplasm http://purl.obolibrary.org/obo/DOID_1192 peripheral nervous system neoplasm A peripheral nervous system neoplasm that is located_in the autonomic nervous system. http://purl.obolibrary.org/obo/DOID_263 kidney cancer http://purl.obolibrary.org/obo/DOID_557 kidney disease A urinary system cancer that is located_in the kidney. http://purl.obolibrary.org/obo/DOID_2634 cystadenoma http://purl.obolibrary.org/obo/DOID_657 adenoma An adenoma that forms a cyst. http://purl.obolibrary.org/obo/DOID_2636 ovarian Brenner tumor http://purl.obolibrary.org/obo/DOID_0060112 ovarian benign neoplasm An ovarian benign neoplasm that has_material_basis_in the surface epithelium of the ovary. http://purl.obolibrary.org/obo/DOID_2639 breast pericanalicular fibroadenoma http://purl.obolibrary.org/obo/DOID_1618 breast fibroadenoma A breast fibroadenoma that is characterized by stromal proliferation around epithelial structures. http://purl.obolibrary.org/obo/DOID_264 hemangiopericytoma http://purl.obolibrary.org/obo/DOID_201 connective tissue cancer A soft tissue cancer that is a soft tissue sarcoma and originates in the pericytes in the walls of capillaries. http://purl.obolibrary.org/obo/DOID_2640 struma ovarii http://purl.obolibrary.org/obo/DOID_2641 ovarian germ cell monodermal and highly specialized teratoma An ovarian germ cell monodermal and highly specialized teratoma that is composed either exclusively or predominantly of thyroid tissue. http://purl.obolibrary.org/obo/DOID_2641 ovarian germ cell monodermal and highly specialized teratoma http://purl.obolibrary.org/obo/DOID_5207 monodermal teratoma A monodermal teratoma that has_material_basis in germ cells that are highly specialized and is located_in the ovary. http://purl.obolibrary.org/obo/DOID_2645 benign mesothelioma http://purl.obolibrary.org/obo/DOID_3314 angiomyolipoma A cell type benign neoplasm that has_material_basis_in mesothelium. http://purl.obolibrary.org/obo/DOID_2649 chondroblastoma http://purl.obolibrary.org/obo/DOID_0060123 connective tissue benign neoplasm A connective tissue benign neoplasm that derives_from chondroblasts and begins in cartilage at the ends of long bones (thighbone, shinbone, humerus) close to the joints. http://purl.obolibrary.org/obo/DOID_2660 cystic teratoma http://purl.obolibrary.org/obo/DOID_0080602 benign teratoma A benign teratoma that is characterized by the presence of cysts or cystic spaces. http://purl.obolibrary.org/obo/DOID_2661 myoepithelioma http://purl.obolibrary.org/obo/DOID_2664 sweat gland benign neoplasm A sweat gland benign neoplasm that is composed_of outgrowths of myoepithelial cells from a sweat gland. http://purl.obolibrary.org/obo/DOID_2671 transitional cell carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A carcinoma that derives_from transitional epithelial cells. http://purl.obolibrary.org/obo/DOID_2673 adult cystic nephroma http://purl.obolibrary.org/obo/DOID_0080615 nephroma A nephroma that is characterized as a localized, well-circumscribed multilocular tumor lined by hobnail epithelium. http://purl.obolibrary.org/obo/DOID_2683 adenofibroma http://purl.obolibrary.org/obo/DOID_0060084 cell type benign neoplasm A cell type benign neoplasm that is composed_of glandular and fibrous tissues, with a relatively large proportion of glands. http://purl.obolibrary.org/obo/DOID_2689 lymphangiosarcoma http://purl.obolibrary.org/obo/DOID_0060073 lymphatic system cancer A lymphatic system cancer that has_material_basis_in endothelial cells located_in lymphatic vessels. http://purl.obolibrary.org/obo/DOID_2691 myoma http://purl.obolibrary.org/obo/DOID_0060095 uterine benign neoplasm A muscle benign neoplasm that is characterized as benign hyperplastic lesions of uterine smooth muscle cells. http://purl.obolibrary.org/obo/DOID_2696 Leydig cell tumor http://purl.obolibrary.org/obo/DOID_192 sex cord-gonadal stromal tumor A sex cord-gonadal stromal tumor that secretes testosterone characterized by excessive proliferation of Leydig cells located_in ovary or testicle. http://purl.obolibrary.org/obo/DOID_270 liver sarcoma http://purl.obolibrary.org/obo/DOID_3571 liver cancer A sarcoma and malignant non-epithelial hepatic and intrahepatic bile duct neoplasm sthat is located_in the liver. http://purl.obolibrary.org/obo/DOID_2710 sick building syndrome http://purl.obolibrary.org/obo/DOID_841 extrinsic allergic alveolitis An extrinsic allergic alveolitis that is characterized by a set of symptoms such as headache, fatigue, eye irritation, and breathing difficulties that affect workers in modern airtight office buildings. The disease is caused by indoor pollutants (as formaldehyde fumes, particulate matter, or microorganisms), and the symptoms tend to disappear when affected individuals leave the building. http://purl.obolibrary.org/obo/DOID_2717 Bloom syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by sun sensitivity, short stature, predisposition to the development of cancer and genomic instability. http://purl.obolibrary.org/obo/DOID_2718 hemopneumothorax http://purl.obolibrary.org/obo/DOID_1673 pneumothorax A pneumothorax that is characterized by having air in the chest cavity and blood in the chest cavity. http://purl.obolibrary.org/obo/DOID_2729 dyskeratosis congenita http://purl.obolibrary.org/obo/DOID_37 skin disease A skin disease characterized by cutaneous pigmentation, premature graying, dystrophy of the nails, leukoplakia of the oral mucosa, continuous lacrimation due to atresia of the lacrimal ducts, often thrombocytopenia, anemia, testicular atrophy in the male carriers and predisposition to cancer. http://purl.obolibrary.org/obo/DOID_2730 epidermolysis bullosa http://purl.obolibrary.org/obo/DOID_2731 vesiculobullous skin disease A vesiculobullous skin disease that is characterized by formation of blisters with only minor skin trauma, which can cause widespread wounds, dehydration, electrolyte abnormalities, and severe infection, frequently develops_from mutations in connective tissue elements, including genes encoding keratin, collagen, and laminin. http://purl.obolibrary.org/obo/DOID_2736 Hajdu-Cheney syndrome http://purl.obolibrary.org/obo/DOID_0080001 bone disease A bone disease characterized by short stature, coarse and dysmorphic facies, bowing of the long bones, and vertebral anomalies that has_material_basis_in heterozygous mutation in NOTCH2 on chromosome 1p12. http://purl.obolibrary.org/obo/DOID_2738 pseudoxanthoma elasticum http://purl.obolibrary.org/obo/DOID_65 connective tissue disease A connective tissue disease that is characterized by the accumulation of deposits of calcium and other minerals in elastic fibers, which are a component of connective tissue, this can result in changes in the skin, eyes, cardiovascular system and gastrointestinal system. http://purl.obolibrary.org/obo/DOID_2739 Gilbert syndrome http://purl.obolibrary.org/obo/DOID_2741 bilirubin metabolic disorder A bilirubin metabolic disorder that involves elevated levels of unconjugated bilirubin as bilirubin is not being conjugated as a result of reduced glucuronyltransferase activity. http://purl.obolibrary.org/obo/DOID_2745 narcissistic personality disorder http://purl.obolibrary.org/obo/DOID_1510 personality disorder A personality disorder that involves an excessive preoccupation with issues of personal adequacy, power, prestige and vanity. http://purl.obolibrary.org/obo/DOID_2752 glycogen storage disease II http://purl.obolibrary.org/obo/DOID_2747 glycogen storage disease A glycogen storage disease that has_material_basis_in deficiency of the lysosomal acid alpha-glucosidase enzyme resulting in damage to muscle and nerve cells due to an accumulation of glycogen in the lysosome. http://purl.obolibrary.org/obo/DOID_2755 Mycobacterium avium complex disease http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that results_in infection, has_material_basis_in Mycobacterium avium complex (MAC), which is transmitted_by inhalation or transmitted_by ingestion of via the respiratory or gastrointestinal tract respectively. The bacteria cause disseminated infection in HIV infected people, while pulmonary disease in immunocompetent persons. http://purl.obolibrary.org/obo/DOID_2772 irritant dermatitis http://purl.obolibrary.org/obo/DOID_2773 contact dermatitis A contact dermatitis that is characterized by a cutaneous inflammatory reaction to repeated contact with an irritant substance, friction, liquid, or adverse temperature that interacts with the skin and often has_symptom erythema, edema, scaling, pain, pruritis, or burning sensation. http://purl.obolibrary.org/obo/DOID_2776 adamantinoma http://purl.obolibrary.org/obo/DOID_184 bone cancer A bone cancer that is located_in almost exclusively in the long bones. http://purl.obolibrary.org/obo/DOID_2784 lung sarcoma http://purl.obolibrary.org/obo/DOID_1324 lung cancer A lung cancer that is located_in the lung and that arises from transformed cells of mesenchymal origin. http://purl.obolibrary.org/obo/DOID_2785 Dandy-Walker syndrome http://purl.obolibrary.org/obo/DOID_2786 cerebellar disease A cerebellar disease that is characterized by hypoplasia and upward rotation of the cerebellar vermis and cystic dilation of the fourth ventricle. http://purl.obolibrary.org/obo/DOID_2790 necatoriasis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that involves infection of the small intestine of humans, dogs and cats by the nematode Necator americanus causing abdominal pain, diarrhea, cramps, weight loss and anemia. Cutaneous larvae migrans in humans is characterized by skin ruptures and severe itching. http://purl.obolibrary.org/obo/DOID_2799 bronchiolitis obliterans http://purl.obolibrary.org/obo/DOID_3082 interstitial lung disease A obstructive lung disease involving obstruction of the bronchioles due to inflammation and fibrosis which occurs as a complication of various lung conditions or physiological insults. http://purl.obolibrary.org/obo/DOID_2855 hyperthyroxinemia http://purl.obolibrary.org/obo/DOID_50 thyroid gland disease A thyroid gland disease that is characterized by elevated thyroxine levels in the blood. http://purl.obolibrary.org/obo/DOID_2870 endometrial adenocarcinoma http://purl.obolibrary.org/obo/DOID_299 adenocarcinoma An endometrial carcinoma that derives_from epithelial cells of glandular origin. http://purl.obolibrary.org/obo/DOID_2871 endometrial carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A endometrial cancer that is located_in the tissue lining the uterus. http://purl.obolibrary.org/obo/DOID_2876 laryngeal squamous cell carcinoma http://purl.obolibrary.org/obo/DOID_1749 squamous cell carcinoma A laryngeal carcinoma that has_material_basis_in squamous cells. http://purl.obolibrary.org/obo/DOID_288 endometriosis of uterus http://purl.obolibrary.org/obo/DOID_345 uterine disease A uterine disease that is characterized by the presence of endometrial tissue grows outside of the endometrium, such as into the myometrium. http://purl.obolibrary.org/obo/DOID_2883 prostatic adenoma http://purl.obolibrary.org/obo/DOID_47 prostate disease A male reproductive organ benign neoplasm that derives_from glandular epithelial cells and that is located_in the prostate. http://purl.obolibrary.org/obo/DOID_2891 thyroid adenoma http://purl.obolibrary.org/obo/DOID_657 adenoma An endocrine organ benign neoplasm that is located_in the thyroid and derives_from glandular epithelial cells. http://purl.obolibrary.org/obo/DOID_2893 cervix carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A cervical cancer that is located_in the cervix uteri or located_in the cervical area and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. http://purl.obolibrary.org/obo/DOID_2907 Goldenhar syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by incomplete development of the ear, nose, soft palate, lip, and mandible. It is associated with anomalous development of the first branchial arch and second branchial arch. http://purl.obolibrary.org/obo/DOID_2908 Treacher Collins syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by bilateral and symmetric downslanting palpebral fissures, malar hypoplasia, micrognathia, and external ear abnormalities. http://purl.obolibrary.org/obo/DOID_2917 cryoglobulinemia http://purl.obolibrary.org/obo/DOID_2916 hypersensitivity reaction type IV disease A hypersensitivity reaction type IV disease that involves large amounts of cryoglobulins in the blood which become thick or gel-like in cold temperatures. http://purl.obolibrary.org/obo/DOID_2926 Klippel-Trenaunay syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by large cutaneous hemangiomata with hypertrophy of the related bones and soft tissues. http://purl.obolibrary.org/obo/DOID_2929 Newcastle disease http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in infection in birds and humans, has_material_basis_in Newcastle disease virus, which is transmitted_by contact with feces and urine of an infected bird, or transmitted_by fomites. The infection has_symptom conjunctivitis, has_symptom headache, and has_symptom lacrimation in humans, and has_symptom gasping, has_symptom coughing, has_symptom twisting of head and neck, has_symptom circling, has_symptom complete paralysis, has_symptom watery diarrhea, and has_symptom reduced egg production in birds. http://purl.obolibrary.org/obo/DOID_2935 Chediak-Higashi syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by oculocutaneous albinism, immune deficiency, coagulation deficiency and neuropathy; it is that has_material_basis_in mutations in the CHS1 gene. http://purl.obolibrary.org/obo/DOID_2942 bronchiolitis http://purl.obolibrary.org/obo/DOID_850 lung disease A lung disease that is an inflammation of the bronchioles, the smallest air passages of the lungs. It is caused by viruses and bacteria. The disease has_symptom cough, has_symptom wheezing, has_symptom shortness of breath, has_symptom fever, has_symptom nasal flaring in infants and has_symptom bluish skin due to lack of oxygen. http://purl.obolibrary.org/obo/DOID_2945 severe acute respiratory syndrome http://purl.obolibrary.org/obo/DOID_0080599 Coronavirus infectious disease A Coronavirus infection that results_in infection located_in respiratory tract, has_material_basis_in SARS coronavirus (SARS-CoV), which is transmitted_by droplet spread of respiratory secretions, transmitted_by ingestion of contaminated food, or transmitted_by fomites. The infection has_symptom fever, has_symptom headache, has_symptom body aches, has_symptom dry cough, and has_symptom hypoxia. http://purl.obolibrary.org/obo/DOID_2960 photosensitive trichothiodystrophy http://purl.obolibrary.org/obo/DOID_0111866 trichothiodystrophy A trichothiodystrophy characterized by skin that is extremely sensitive to ultraviolet (UV) rays from sunlight. http://purl.obolibrary.org/obo/DOID_2962 Cockayne syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that has_material_basis_in rare mutations in two DNA excision repair proteins, ERCC-8 and ERCC-6, and characterized by growth failure, impaired development of the nervous system, abnormal sensitivity to sunlight (photosensitivity), and premature aging. http://purl.obolibrary.org/obo/DOID_2977 primary hyperoxaluria http://purl.obolibrary.org/obo/DOID_2978 carbohydrate metabolic disorder A carbohydrate metabolic disorder characterized by impaired glyoxylate metabolism resulting in accumulation of oxalate throughout the body typically manifesting as kidney and bladder stones. http://purl.obolibrary.org/obo/DOID_2986 IgA glomerulonephritis http://purl.obolibrary.org/obo/DOID_2921 glomerulonephritis A glomerulonephritis characterized by build up of IgA antibody in the glomerulus. http://purl.obolibrary.org/obo/DOID_2987 familial Mediterranean fever http://purl.obolibrary.org/obo/DOID_417 autoimmune disease An autoimmune disease characterized by recurrent episodes of fever and acute inflammation of the membranes lining the abdomen, joints and lungs; that has_material_basis_in mutations in the MEFV gene, which encodes the protein pyrin. http://purl.obolibrary.org/obo/DOID_2988 antiphospholipid syndrome http://purl.obolibrary.org/obo/DOID_0060051 autoimmune disease of cardiovascular system An autoimmune disease that is characterized by recurrent venous or arterial thrombosis and/or fetal losses associated with characteristic elevated levels of antibodies directed against membrane anionic phospholipids (anticardiolipin). http://purl.obolibrary.org/obo/DOID_2994 germ cell cancer http://purl.obolibrary.org/obo/DOID_0050687 cell type cancer A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from germ cells. http://purl.obolibrary.org/obo/DOID_2997 Sertoli-Leydig cell tumor http://purl.obolibrary.org/obo/DOID_192 sex cord-gonadal stromal tumor A sex cord-gonadal stromal tumor characterized by variable proportions of Sertoli cells, Leydig cells, primitive gonadal stroma and/or heterologous elements located_in the ovaries and testicles. http://purl.obolibrary.org/obo/DOID_2999 granulosa cell tumor http://purl.obolibrary.org/obo/DOID_192 sex cord-gonadal stromal tumor A sex cord-gonadal stromal tumor that has_material_basis_in granulosa cells and arises from the sex cord stroma. http://purl.obolibrary.org/obo/DOID_3010 lobular neoplasia http://purl.obolibrary.org/obo/DOID_8791 breast carcinoma in situ A breast carcinoma in situ that is characterized by abnormal cells are found in the lobules (glands that make milk) of the breast. http://purl.obolibrary.org/obo/DOID_3012 Li-Fraumeni syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by autosomal dominant inheritance of increased risk of developing several types of cancer, including breast cancer, osteosarcomata and soft tissue sarcomata. http://purl.obolibrary.org/obo/DOID_3016 breast malignant phyllodes tumor http://purl.obolibrary.org/obo/DOID_1612 breast cancer A breast cancer that is characterized by a prominent infiltrative border, unequivocal sarcomatous areas, and stromal overgrowth and arises_from the stroma, lined by an epithelial and myoepithelial bilayer, forming a leaflike structure. They tend to grow rapidly and present in middle-aged women (40s-50s). http://purl.obolibrary.org/obo/DOID_3017 breast sarcoma http://purl.obolibrary.org/obo/DOID_1612 breast cancer A breast cancer that has_material_basis_in abnormally proliferating cells derives_from mesenchymal cells. http://purl.obolibrary.org/obo/DOID_3025 acinar cell carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A carcinoma that has_material_basis_in abnormally proliferating cells, derives_from spindle cells and/or derives_from giant cells. http://purl.obolibrary.org/obo/DOID_3030 mucinous adenocarcinoma http://purl.obolibrary.org/obo/DOID_299 adenocarcinoma An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which produce mucin. http://purl.obolibrary.org/obo/DOID_3042 allergic contact dermatitis http://purl.obolibrary.org/obo/DOID_1205 allergic disease A contact dermatitis that is an allergic skin reaction to foreign chemical or substances leading to red, itchy, weepy reaction where the skin has come into contact with a substance that the immune system recognizes as foreign. http://purl.obolibrary.org/obo/DOID_3049 Churg-Strauss syndrome http://purl.obolibrary.org/obo/DOID_865 vasculitis A vasculitits that is systemic vasculitis realized as blood vessel inflammation and has_symptom asthma along with hay fever, rash and gastrointestinal bleeding. http://purl.obolibrary.org/obo/DOID_3055 paratyphoid fever http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Salmonella enterica subsp enterica serovar Paratyphi A, B or C, which are transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom headache, has_symptom abdominal pain, has_symptom malaise, has_symptom anorexia, has_symptom constipation, has_symptom rosy spots on the central body, has_symptom non productive cough (in early stage of illness), has_symptom bradycardia, and has_symptom hepatosplenomegaly. http://purl.obolibrary.org/obo/DOID_3069 astrocytoma http://purl.obolibrary.org/obo/DOID_3070 malignant glioma A malignant glioma that is has_material_basis_in astrocyte cells, a type of star-shaped glial cell, located in the brain and spinal cord. http://purl.obolibrary.org/obo/DOID_3071 gliosarcoma http://purl.obolibrary.org/obo/DOID_3068 glioblastoma A gliomablastoma that is characterized by a biphasic tissue pattern with alternating areas displaying glial and mesenchymal differentiation. http://purl.obolibrary.org/obo/DOID_3083 chronic obstructive pulmonary disease http://purl.obolibrary.org/obo/DOID_2320 obstructive lung disease An obstructive lung disease that is characterized by irreversible airflow obstruction due to chronic bronchitis, emphysema, and/or small airways disease. http://purl.obolibrary.org/obo/DOID_3095 germ cell and embryonal cancer http://purl.obolibrary.org/obo/DOID_1115 sarcoma A germ cell cancer that is derives_from a mixture of germs cells and embryonal cells. http://purl.obolibrary.org/obo/DOID_3103 thoracic outlet syndrome http://purl.obolibrary.org/obo/DOID_178 vascular disease A vascular disease that is characterized by compression at the superior thoracic outlet[1] resulting from excess pressure placed on a neurovascular bundle passing between the anterior scalene and middle scalene muscles. http://purl.obolibrary.org/obo/DOID_3108 ascaridiasis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that involves infection of the intestine of humans and birds with nematodes of the genus Ascaridia. http://purl.obolibrary.org/obo/DOID_3111 cystadenocarcinoma http://purl.obolibrary.org/obo/DOID_60004 malignant cystadenoma An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, in which cystic accumulations of retained secretions are formed. http://purl.obolibrary.org/obo/DOID_3112 papillary adenocarcinoma http://purl.obolibrary.org/obo/DOID_299 adenocarcinoma An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which form complex papillary structures and exhibit compressive, destructive growth that replaces the normal tissue. http://purl.obolibrary.org/obo/DOID_3114 serous cystadenocarcinoma http://purl.obolibrary.org/obo/DOID_3111 cystadenocarcinoma A cystadenocarcinoma that derives_from epithelial cells originating in glandular tissue forming serous lesions. http://purl.obolibrary.org/obo/DOID_3118 hepatobiliary disease http://purl.obolibrary.org/obo/DOID_77 gastrointestinal system disease A gastrointestinal system disease that is located_in the liver and/or biliary tract. http://purl.obolibrary.org/obo/DOID_3125 multiple endocrine neoplasia http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by tumors in at least two endocrine glands. http://purl.obolibrary.org/obo/DOID_3127 proctitis http://purl.obolibrary.org/obo/DOID_1285 rectal disease A rectal disease that involves inflammation of the rectal mucosa, which results from infection, inflammatory bowel disease, or radiation. Sexually transmitted pathogens (Neisseria gonorrhoeae, Chlamydia trachomatis, herpes simplex virus 1 and 2, Treponema pallidum) and enteric pathogens (Campylobacter, Shigella, Salmonella) are involved in the disease. Symptoms are rectal discomfort and bleeding. http://purl.obolibrary.org/obo/DOID_3132 porphyria cutanea tarda http://purl.obolibrary.org/obo/DOID_3133 acute porphyria An acute porphyria characterized by painful, blistering skin lesions that develop on sun-exposed skin. http://purl.obolibrary.org/obo/DOID_3141 mucinoses http://purl.obolibrary.org/obo/DOID_65 connective tissue disease A connective tissue disease characterized by accumulation of glycosaminoglycan located_in the dermal tissue. http://purl.obolibrary.org/obo/DOID_3144 cutis laxa http://purl.obolibrary.org/obo/DOID_37 skin disease A skin disease characterized by loose, hanging, wrinkled skin lacking in elasticity. http://purl.obolibrary.org/obo/DOID_3185 spinal cord glioma http://purl.obolibrary.org/obo/DOID_5612 spinal cancer A spinal cancer that is located in the spinal cord and has_material_basis_in glial cells. http://purl.obolibrary.org/obo/DOID_3191 nemaline myopathy http://purl.obolibrary.org/obo/DOID_422 congenital structural myopathy A congenital structural myopathy characterized by generally non-progressive muscle weakness of varying severity; certain muscle fibers show the presence of rod-like structures called nemaline bodies. http://purl.obolibrary.org/obo/DOID_3193 peripheral nerve sheath neoplasm http://purl.obolibrary.org/obo/DOID_1192 peripheral nervous system neoplasm A peripheral nervous system neoplasm that is located in the connective tissue surrounding nerves. http://purl.obolibrary.org/obo/DOID_3200 cerebellopontine angle tumor http://purl.obolibrary.org/obo/DOID_4203 brain stem cancer A brain stem cancer that is characterized by neoplasms in the fossa located_in cerebellopotine angle. http://purl.obolibrary.org/obo/DOID_321 tropical spastic paraparesis http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results in inflammation located in spinal cord, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted by sexual contact, and transmitted by breast feeding. The infection has symptom spastic weakness of both legs, has symptom muscle stiffness, has symptom sensory disturbance, and has symptom spasms. http://purl.obolibrary.org/obo/DOID_3210 Pelizaeus-Merzbacher disease http://purl.obolibrary.org/obo/DOID_0080012 X-linked recessive disease A hypomyelinating leukodystrophy characterized by impaired myelin formation, nystagmus, spastic quadriplegia, ataxia, and developmental delay that has_material_basis_in mutation in the PLP1 gene on chromosome Xq22. http://purl.obolibrary.org/obo/DOID_322 myelitis http://purl.obolibrary.org/obo/DOID_319 spinal cord disease A spinal cord disease that is characterized by inflammation of the white matter or gray matter of the spinal cord. http://purl.obolibrary.org/obo/DOID_3240 aspiration pneumonitis http://purl.obolibrary.org/obo/DOID_552 pneumonia A pneumonia that is defined as an acute lung injury after the inhalation of foreign material such as regurgitated acidic gastric contents, petroleum products and laxative oils. This syndrome occurs in patients who have a marked disturbance of consciousness such as that resulting from a drug overdose, seizures, a massive cerebrovascular accident, or the use of anesthesia. Aspiration of gastric contents results in a chemical burn of the tracheobronchial tree and pulmonary parenchyma, causing an intense parenchymal inflammatory reaction. The disease has_symptom non-productive cough, has_symptom tachypnea, has_symptom bronchospasm, has_symptom bloody sputum, has_symptom frothy sputum, or has_symptom respiratory distress, 2-5 hrs after aspiration. http://purl.obolibrary.org/obo/DOID_3241 lipid pneumonia http://purl.obolibrary.org/obo/DOID_3240 aspiration pneumonitis An aspiration pneumonitis resulting from the aspiration of lipids. It is the result of a foreign body-type reaction to the presence of lipid material within the lung parenchyma. It is caused by inhalation of nasal drops with oil base or cosmetic oil and aspiration of mineral oil when used as a laxative agent. http://purl.obolibrary.org/obo/DOID_3247 rhabdomyosarcoma http://purl.obolibrary.org/obo/DOID_4043 skeletal muscle cancer A skeletal muscle cancer that arise from skeletal muscle progenitors. http://purl.obolibrary.org/obo/DOID_3252 prostate rhabdomyosarcoma http://purl.obolibrary.org/obo/DOID_4054 prostate sarcoma A rhabdomyosarcoma and sarcoma of prostate that is located_in the prostate. http://purl.obolibrary.org/obo/DOID_3261 hyper IgE recurrent infection syndrome 1 http://purl.obolibrary.org/obo/DOID_0080545 hyper IgE syndrome A hyper IgE syndrome that has_material_basis_in heterozygous mutation in the STAT3 gene on chromosome 17q21. http://purl.obolibrary.org/obo/DOID_3262 phagocyte bactericidal dysfunction http://purl.obolibrary.org/obo/DOID_612 primary immunodeficiency disease A primary immunodeficiency disease where phagocytes have a diminished ability to fight bacterial infection. http://purl.obolibrary.org/obo/DOID_3263 piebaldism http://purl.obolibrary.org/obo/DOID_16 integumentary system disease An integumentary system disease characterized by congenital absence of melanocytes in areas of the skin and hair that has_material_basis_in heterozygous mutation in either KIT or SNAI2 on chromosome 4q12 or 8q11.21, respectively. http://purl.obolibrary.org/obo/DOID_3265 chronic granulomatous disease http://purl.obolibrary.org/obo/DOID_850 lung disease A phagocyte bactericidal dysfunction characterized by an inability to resist repeated infectious diseases and a tendency to develop chronic inflammation. Life-threatening recurrent fungal and bacterial infections affecting the skin, lungs, and bones may occur along with swollen areas of inflamed tissues known as granulomas that can be widely distributed. http://purl.obolibrary.org/obo/DOID_3269 ovarian cystadenoma http://purl.obolibrary.org/obo/DOID_0060112 ovarian benign neoplasm An ovarian benign neoplasm that has_material_basis_in glandular epithelial tissue in which cystic accumulations of retained secretions are formed. http://purl.obolibrary.org/obo/DOID_3275 thymoma http://purl.obolibrary.org/obo/DOID_3277 thymus cancer A thymus cancer that derives_from epithelial cells located_in the thymus. The tumor cells in a thymoma look similar to the normal cells of the thymus, grow slowly, and rarely spread beyond the thymus. http://purl.obolibrary.org/obo/DOID_3284 thymic carcinoma http://purl.obolibrary.org/obo/DOID_3277 thymus cancer A thymus cancer that derives_from epithelial cells. The tumor cells in a thymic carcinoma look very different from the normal cells of the thymus, grow more quickly, and have usually spread to other parts of the body when the cancer is found. http://purl.obolibrary.org/obo/DOID_3292 monkeypox http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results in infection of primates, rodents and humans, located in skin, has_material_basis_in Monkeypox virus, which is transmitted by contact with the animal's blood, body fluids, rash, or with the body fluids of a sick person, transmitted by fomites, and transmitted by respiratory droplets. The infection has symptom fever, has symptom muscle ache, has symptom headache, and has symptom lymphadenopathy. http://purl.obolibrary.org/obo/DOID_3298 vaccinia http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in infection, located_in skin, has_material_basis_in Vaccinia virus, which is used as a live vaccine against smallpox. The virus is transmitted_by contact with the vaccination site before it has healed, or transmitted_by fomites that have been contaminated with live virus from the vaccination site. The infection has_symptom rash, has_symptom fever, and has_symptom body aches. http://purl.obolibrary.org/obo/DOID_3301 gonadoblastoma http://purl.obolibrary.org/obo/DOID_0060084 cell type benign neoplasm A cell type benign neoplasm that is composed_of a mixture of gonadal elements, such as large primordial germ cells, immature Sertoli cells or granulosa cells of the sex cord, and gonadal stromal cells (which comprises the granulosa, theca, and fibrocyte cells). http://purl.obolibrary.org/obo/DOID_3303 notochordal cancer http://purl.obolibrary.org/obo/DOID_184 bone cancer An embryonal cancer and bone cancer and mesenchymal cell neoplasm that is located_in the notochord. http://purl.obolibrary.org/obo/DOID_3304 germinoma http://purl.obolibrary.org/obo/DOID_2994 germ cell cancer A germ cell cancer that lacks histologic differentiation. It usually refers to a tumor in the brain. http://purl.obolibrary.org/obo/DOID_3305 teratocarcinoma http://purl.obolibrary.org/obo/DOID_3095 germ cell and embryonal cancer A mixed germ cell tumor that is a mixture of teratoma with embryonal carcinoma, or with choriocarcinoma, or with both. http://purl.obolibrary.org/obo/DOID_3307 teratoma http://purl.obolibrary.org/obo/DOID_3095 germ cell and embryonal cancer A germ cell and embryonal cancer that is an encapsulated tumor with tissue or organ components resembling normal derivatives of all three germ layers. http://purl.obolibrary.org/obo/DOID_3308 embryonal carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma An embryonal cancer that is a type of germ cell tumour that is located_in the ovaries or located_in the testes. http://purl.obolibrary.org/obo/DOID_3314 angiomyolipoma http://purl.obolibrary.org/obo/DOID_0060084 cell type benign neoplasm A cell type benign neoplasm that is primarily located in the kidneys but may be found in the lungs, liver or other organs and is derived from perivascular epithelioid cells. http://purl.obolibrary.org/obo/DOID_3319 lymphangioleiomyomatosis http://purl.obolibrary.org/obo/DOID_850 lung disease A lung disease that is characterized by progressive cystic destruction of the lung and lymphatic abnormalities, frequently associated with renal angiomyolipomas. http://purl.obolibrary.org/obo/DOID_3321 GM2 gangliosidosis http://purl.obolibrary.org/obo/DOID_2368 gangliosidosis A gangliosidosis that is characterized by excessive accumulation of ganglioside GM2 and related glycolipids in the lysosomes. http://purl.obolibrary.org/obo/DOID_3323 Sandhoff disease http://purl.obolibrary.org/obo/DOID_3321 GM2 gangliosidosis A GM2 gangliosidosis that is characterized by an accumulation of GM2 gangliosides, particularly in neurons, and that has_material_basis_in mutation in the beta subunit of hexosaminidase (HEXB) on chromosome 5q13. http://purl.obolibrary.org/obo/DOID_334 histrionic personality disorder http://purl.obolibrary.org/obo/DOID_1510 personality disorder A personality disorder that is characterized by a pattern of excessive emotionality and attention-seeking, including an excessive need for approval and inappropriately seductive behavior, usually beginning in early adulthood. http://purl.obolibrary.org/obo/DOID_3341 osteitis fibrosa http://purl.obolibrary.org/obo/DOID_0080011 bone resorption disease A bone resorption disease that has_material_basis_in hyperparathyroidism which results_in hyperactivity in osteoclasts, deformity, and loss of mass located_in bone. http://purl.obolibrary.org/obo/DOID_3343 glycoproteinosis http://purl.obolibrary.org/obo/DOID_0080488 mucolipidosis A mucolipidosis that is characterized by a deficiency of the enzyme alpha-N -acetyl neuraminidase (sialidase). http://purl.obolibrary.org/obo/DOID_3345 xanthomatosis http://purl.obolibrary.org/obo/DOID_9455 lipid storage disease A lipid storage disease that is characterized by the desposition of yellowish cholesterol-rich material in tendons or other body parts. http://purl.obolibrary.org/obo/DOID_3347 osteosarcoma http://purl.obolibrary.org/obo/DOID_0080639 bone sarcoma A bone sarcoma that is located_in bone that has_material_basis_in cells of mesenchymal origin. http://purl.obolibrary.org/obo/DOID_3355 fibrosarcoma http://purl.obolibrary.org/obo/DOID_201 connective tissue cancer A connective tissue cancer that has_material_basis_in fibrous connective tissue and characterized by the presence of immature proliferating fibroblasts or undifferentiated anaplastic spindle cells in a storiform pattern. http://purl.obolibrary.org/obo/DOID_3382 liposarcoma http://purl.obolibrary.org/obo/DOID_3939 lipomatous cancer A lipomatous cancer that arises in fat cells in deep soft tissue retroperitoneum and the extremities. http://purl.obolibrary.org/obo/DOID_3385 bacterial vaginosis http://purl.obolibrary.org/obo/DOID_2170 vaginitis A vaginitis that is characterized by a grayish vaginal discharge usually of foul odor and the presence of Gardnerella vaginalis. http://purl.obolibrary.org/obo/DOID_3389 Papillon-Lefevre disease http://purl.obolibrary.org/obo/DOID_1091 tooth disease An ectodermal dysplasia that is characterized by palmoplantar keratoderma associated with early-onset periodontitis and has_material_basis_in homozygous or compound heterozygous mutation in the cathepsin C gene on chromosome 11q14. http://purl.obolibrary.org/obo/DOID_3405 histiocytosis http://purl.obolibrary.org/obo/DOID_75 lymphatic system disease A lymphatic system disease that is characterized by an excessive number of histiocytes. http://purl.obolibrary.org/obo/DOID_3413 alpha-mannosidosis http://purl.obolibrary.org/obo/DOID_3211 lysosomal storage disease A lysosomal storage disease that has_material_basis_in deficiency of the alpha-D-manosidase enzyme resulting in the impairment of cell function from a build up of complex sugars derived from glycoproteins in the lysosome. http://purl.obolibrary.org/obo/DOID_3429 inclusion body myositis http://purl.obolibrary.org/obo/DOID_633 myositis A myositis that is characterized by late onset of skeletal muscle inflammation, weakness, and atrophy with cytoplasmic granules and vacuoles in the muscle. http://purl.obolibrary.org/obo/DOID_3443 mammary Paget's disease http://purl.obolibrary.org/obo/DOID_3458 breast adenocarcinoma A breast adenocarcinoma that has_material_basis_in epidermal Paget cells, which are malignant glandular epithelial cells with abundant and clear cytoplasm, usually containing mucin, and pleomorphic and hyperchromatic nucleus. http://purl.obolibrary.org/obo/DOID_3447 anus adenocarcinoma http://purl.obolibrary.org/obo/DOID_299 adenocarcinoma An anal carcinoma that originating in the cortex of the adrenal gland and derives_from epithelial cells of glandular origin. http://purl.obolibrary.org/obo/DOID_3449 penis carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A penile cancer that is located_in the skin or tissues of the penis. http://purl.obolibrary.org/obo/DOID_3454 brain infarction http://purl.obolibrary.org/obo/DOID_6713 cerebrovascular disease A cerebrovascular disease that is characterized by tissue necrosis located_in the brain, resulting from inadequate blood flow through the brain. http://purl.obolibrary.org/obo/DOID_3457 invasive lobular carcinoma http://purl.obolibrary.org/obo/DOID_0050938 breast lobular carcinoma A breast lobular carcinoma that is characterized by infiltration into the tissue of the breast outside of the lobule where it originated. http://purl.obolibrary.org/obo/DOID_3458 breast adenocarcinoma http://purl.obolibrary.org/obo/DOID_3459 breast carcinoma A breast carcinoma that originates in the milk ducts and/or lobules (glandular tissue) of the breast. http://purl.obolibrary.org/obo/DOID_348 blepharochalasis http://purl.obolibrary.org/obo/DOID_530 eyelid disease An eyelid disease that is characterized by exacerbations and remissions of eyelid edema, which results in a stretching and subsequent atrophy of the eyelid tissue, leading to the formation of redundant folds over the lid margins. http://purl.obolibrary.org/obo/DOID_3492 mixed connective tissue disease http://purl.obolibrary.org/obo/DOID_854 collagen disease A collagen disease that is considered an overlap of three diseases, systemic lupus erythematosus, scleroderma, and polymyositis with very high titers of circulating antinuclear antibody to a ribonucleoprotein antigen. http://purl.obolibrary.org/obo/DOID_3493 signet ring cell adenocarcinoma http://purl.obolibrary.org/obo/DOID_299 adenocarcinoma An adenocarcinoma that derives_from epithelial cells originating in glandular tissue, which have signet ring appearance. http://purl.obolibrary.org/obo/DOID_3498 pancreatic ductal adenocarcinoma http://purl.obolibrary.org/obo/DOID_4074 pancreatic adenocarcinoma A pancreatic adenocarcinoma that derives_from pancreatic duct cells. http://purl.obolibrary.org/obo/DOID_3507 dermatofibrosarcoma protuberans http://purl.obolibrary.org/obo/DOID_3355 fibrosarcoma A fibrosarcoma that is located_in the dermis laryer of the skin and that begins as a hard nodule and grows slowly. http://purl.obolibrary.org/obo/DOID_3526 cerebral infarction http://purl.obolibrary.org/obo/DOID_3454 brain infarction A cerebrovascular disease that is characterized by an area of necrotic tissue in the brain resulting from a blockage or narrowing in the arteries supplying blood and oxygen to the brain. http://purl.obolibrary.org/obo/DOID_3535 Unverricht-Lundborg syndrome http://purl.obolibrary.org/obo/DOID_891 progressive myoclonus epilepsy A progressive myoclonus epilepsy characterized by onset between 6 and 13 years of age of action- and stimulus-sensitive myoclonus, tonic-clonic seizures with ataxia, and a mild cognitive decline. http://purl.obolibrary.org/obo/DOID_3540 choroid plexus cancer http://purl.obolibrary.org/obo/DOID_3541 cerebral ventricle cancer A cerebral ventricle cancer that is located_in the plexus located_in the ventricles of the brain. http://purl.obolibrary.org/obo/DOID_355 mast-cell sarcoma http://purl.obolibrary.org/obo/DOID_1115 sarcoma A sarcoma that has_material_basis in mast cells. http://purl.obolibrary.org/obo/DOID_3559 pseudomyxoma peritonei http://purl.obolibrary.org/obo/DOID_11239 appendix cancer An appendix cancer that is characterized by progressive accumulation of mucus-secreting tumor cells within the abdomen and pelvis. http://purl.obolibrary.org/obo/DOID_3571 liver cancer http://purl.obolibrary.org/obo/DOID_0080355 hepatobiliary system cancer A hepatobiliary system cancer that is located_in the liver. http://purl.obolibrary.org/obo/DOID_3577 Sertoli cell tumor http://purl.obolibrary.org/obo/DOID_192 sex cord-gonadal stromal tumor A sex cord-gonadal stromal tumor characterized by excessive proliferation of Sertoli cells. http://purl.obolibrary.org/obo/DOID_3594 choriocarcinoma http://purl.obolibrary.org/obo/DOID_2021 placenta cancer A placenta cancer that has_material_basis_in trophoblastic cells. http://purl.obolibrary.org/obo/DOID_3596 placental site trophoblastic tumor http://purl.obolibrary.org/obo/DOID_3594 choriocarcinoma A choriocarcinoma that is characterized by low beta-hCG levels and arises from neoplastic transformation of intermediate trophoblastic cells. http://purl.obolibrary.org/obo/DOID_3602 toxic encephalopathy http://purl.obolibrary.org/obo/DOID_863 nervous system disease A nervous system disease that results from exposure to neurotoxicants and is characterized by an altered mental status, memory loss, and visual problems. http://purl.obolibrary.org/obo/DOID_3603 mucinous cystadenocarcinoma http://purl.obolibrary.org/obo/DOID_3111 cystadenocarcinoma A cystadenocarcinoma that derives_from epithelial cells originating in glandular tissue, with a capsulated structure and mucus-producing cells. http://purl.obolibrary.org/obo/DOID_3604 ovarian mucinous cystadenocarcinoma http://purl.obolibrary.org/obo/DOID_3605 ovarian cystadenocarcinoma An ovarian cystadenocarcinoma that is characterized by the presence of mucin. http://purl.obolibrary.org/obo/DOID_3605 ovarian cystadenocarcinoma http://purl.obolibrary.org/obo/DOID_3713 ovary adenocarcinoma An ovary adenocarcinoma that is characterized by the presence of cysts or cystic spaces. http://purl.obolibrary.org/obo/DOID_3606 ovarian mucinous adenocarcinoma http://purl.obolibrary.org/obo/DOID_3713 ovary adenocarcinoma An ovary adenocarcinoma that is characterized by the presence of mucin. http://purl.obolibrary.org/obo/DOID_3608 appendix adenocarcinoma http://purl.obolibrary.org/obo/DOID_299 adenocarcinoma An appendix carcinoma that derives_from epithelial cells of glandular origin. http://purl.obolibrary.org/obo/DOID_361 cervix endometriosis http://purl.obolibrary.org/obo/DOID_2253 cervix disease A cervix disease that is characterized by the growth endometrial tissue that is located on the cervix. http://purl.obolibrary.org/obo/DOID_3614 Kallmann syndrome http://purl.obolibrary.org/obo/DOID_0090070 hypogonadotropic hypogonadism A hypogonadotropic hypogonadism with a defective sense of smell (anosmia or hyposmia). http://purl.obolibrary.org/obo/DOID_3616 angiolipoma http://purl.obolibrary.org/obo/DOID_3315 lipoma A lipoma that is a painful subcutaneous nodule, having all other features of a typical lipoma. http://purl.obolibrary.org/obo/DOID_3633 beta-mannosidosis http://purl.obolibrary.org/obo/DOID_3211 lysosomal storage disease A lysosomal storage disease that has_material_basis_in deficiency of the beta-A-manosidase enzyme resulting in the disruption of N-linked glycoprotein oligosaccharide catabolism. http://purl.obolibrary.org/obo/DOID_3635 congenital myasthenic syndrome http://purl.obolibrary.org/obo/DOID_439 neuromuscular junction disease A neuromuscular junction disease that is characterized by weakness and easy fatiguability resulting from a genetic defect at the junction where the nerve stimulates muscle activity that result in muscle weakness and may affect nerve cells (presynaptic), muscle cells (postsynaptic) or the space between nerve and muscle cells (synaptic). http://purl.obolibrary.org/obo/DOID_3640 central nervous system teratoma http://purl.obolibrary.org/obo/DOID_1115 sarcoma A teratoma that is located_in the central nervous system. http://purl.obolibrary.org/obo/DOID_3649 pyruvate decarboxylase deficiency http://purl.obolibrary.org/obo/DOID_2978 carbohydrate metabolic disorder A carbohydrate metabolic disorder characterized by the buildup of lactic acid in the body and a variety of neurological problems and caused by a deficiency of one of the three enzymes in the pyruvate dehydrogenase complex. http://purl.obolibrary.org/obo/DOID_3652 Leigh disease http://purl.obolibrary.org/obo/DOID_700 mitochondrial metabolism disease A mitochondrial metabolism disease characterized by progressive loss of mental and movement abilities. Symptoms usually begin between ages of three months and two years and include loss of appetite, vomiting, irritability and seizure activity. http://purl.obolibrary.org/obo/DOID_3659 sialuria http://purl.obolibrary.org/obo/DOID_3211 lysosomal storage disease A lysosomal storage disease characterized by increased sialic acid in the urine. http://purl.obolibrary.org/obo/DOID_3664 mast cell neoplasm http://purl.obolibrary.org/obo/DOID_2531 hematologic cancer A hematologic cancer that has_material_basis_in mast cells. http://purl.obolibrary.org/obo/DOID_3672 rhabdoid cancer http://purl.obolibrary.org/obo/DOID_3675 childhood kidney cancer A childhood kidney neoplasm that is located_in the kidney, liver, muscle, heart, lung, soft tissues, skin and central nervous system. http://purl.obolibrary.org/obo/DOID_3687 MELAS syndrome http://purl.obolibrary.org/obo/DOID_890 mitochondrial encephalomyopathy A mitochondrial encephalomyopathy that is characterized by mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes, has_symptom myalgia, motor weakness, headaches, seizures, and stroke-like episodes with acute hemiparesis and severe headaches, and develops_from mutation in mitochondrial genes including MT-TL1, which encodes tRNA proteins. http://purl.obolibrary.org/obo/DOID_3706 fallopian tube adenocarcinoma http://purl.obolibrary.org/obo/DOID_299 adenocarcinoma A fallopian tube carcinoma that derives_from epithelial cells of glandular origin. http://purl.obolibrary.org/obo/DOID_3711 bladder adenocarcinoma http://purl.obolibrary.org/obo/DOID_299 adenocarcinoma A bladder carcinoma that derives_from epithelial cells of glandular origin. http://purl.obolibrary.org/obo/DOID_3713 ovary adenocarcinoma http://purl.obolibrary.org/obo/DOID_4001 ovarian carcinoma An ovarian carcinoma that derives_from epithelial cells of glandular origin. http://purl.obolibrary.org/obo/DOID_3733 theileriasis http://purl.obolibrary.org/obo/DOID_2789 parasitic protozoa infectious disease A parasitic protozoa infectious disease that involves infection of humans and cattle caused by a genus of parasitic protozoa Theileria, which is transmitted by ixodid ticks. http://purl.obolibrary.org/obo/DOID_3737 verrucous carcinoma http://purl.obolibrary.org/obo/DOID_1749 squamous cell carcinoma A squamous cell carcinoma that is a diffuse, papillary, non metastasizing, well differentiated, malignant neoplasm of epidermis or oral epithelium. http://purl.obolibrary.org/obo/DOID_374 nutrition disease http://purl.obolibrary.org/obo/DOID_0060158 acquired metabolic disease An acquired metabolic disease that is characterized by an insufficient intake of food or of certain nutrients, by an inability of the body to absorb and use nutrients, or by overconsumption of certain foods. http://purl.obolibrary.org/obo/DOID_3744 cervical squamous cell carcinoma http://purl.obolibrary.org/obo/DOID_1749 squamous cell carcinoma A cervix carcinoma that has_material_basis_in squamous cells of the cervix. http://purl.obolibrary.org/obo/DOID_3748 esophagus squamous cell carcinoma http://purl.obolibrary.org/obo/DOID_1749 squamous cell carcinoma An esophageal carcinoma that derives_from epithelial squamous cells located_in the esophagus. http://purl.obolibrary.org/obo/DOID_3755 antithrombin III deficiency http://purl.obolibrary.org/obo/DOID_2452 thrombophilia A thrombophilia that is characterized by the tendency to form clots in the veins. http://purl.obolibrary.org/obo/DOID_3756 protein C deficiency http://purl.obolibrary.org/obo/DOID_2452 thrombophilia A thrombophilia that is characterized by recurrent venous thrombosis and that has_material_basis_in heterozygous mutation in the PROC gene on chromosome 2q14. http://purl.obolibrary.org/obo/DOID_3764 Denys-Drash syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by the association of diffuse mesangial sclerosis (DMS), male pseudohermaphroditism with a 46,XY karyotype, and nephroblastoma that derives_from an abnormality in the WT1 gene (Wilms' tumor suppressor gene). http://purl.obolibrary.org/obo/DOID_3766 leukorrhea http://purl.obolibrary.org/obo/DOID_3767 vaginal discharge A vaginal discharge that is characterized by a whitish or yellow color. http://purl.obolibrary.org/obo/DOID_3767 vaginal discharge http://purl.obolibrary.org/obo/DOID_121 vaginal disease A vaginal disease that is characterized by the presence of discharge. http://purl.obolibrary.org/obo/DOID_3781 anovulation http://purl.obolibrary.org/obo/DOID_1100 ovarian disease An ovarian disease that is characterized by the absence of ovulation. http://purl.obolibrary.org/obo/DOID_3783 Coffin-Lowry syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by skeletal malformations, growth retardation, hearing deficit, paroxysmal movement disorders, and cognitive impairment in affected males and some carrier females, and has_material_basis_in mutation in the RSK2 gene on chromosome Xp22. http://purl.obolibrary.org/obo/DOID_3818 photoallergic dermatitis http://purl.obolibrary.org/obo/DOID_3042 allergic contact dermatitis An allergic contact dermatitis that is characterized by a delayed-type hypersensitivity cutaneous reaction in response to a photoantigen applied to the skin in individuals previously sensitized to the same substance, and has_symptom erythematous papules, vesicles, or eczema. http://purl.obolibrary.org/obo/DOID_3827 congenital diaphragmatic hernia http://purl.obolibrary.org/obo/DOID_10481 diaphragm disease A diaphragm disease characterized by the lack of development of all or part of the diaphragm, which results in an abnormal opening that allows the stomach and intestines to move into the chest cavity and crowd the heart and lungs. http://purl.obolibrary.org/obo/DOID_3829 pituitary adenoma http://purl.obolibrary.org/obo/DOID_60009 pituitary gland benign neoplasm A pituitary gland benign neoplasm that derives_from glandular epithelial cells. http://purl.obolibrary.org/obo/DOID_3857 large cell medulloblastoma http://purl.obolibrary.org/obo/DOID_0050902 medulloblastoma A medulloblastoma that is characterized by cells that are larger than would be normally expected. http://purl.obolibrary.org/obo/DOID_3891 placental insufficiency http://purl.obolibrary.org/obo/DOID_780 placenta disease A placenta disease that is characterized by insufficient blood flow to the placenta during pregnancy. http://purl.obolibrary.org/obo/DOID_3892 insulinoma http://purl.obolibrary.org/obo/DOID_0060084 cell type benign neoplasm A pancreatic cystadenoma that is characterized by the overproduction of insulin. http://purl.obolibrary.org/obo/DOID_3896 hidradenoma http://purl.obolibrary.org/obo/DOID_2664 sweat gland benign neoplasm A sweat gland benign neoplasm that is located_in an apical sweat gland. http://purl.obolibrary.org/obo/DOID_3901 vulvitis http://purl.obolibrary.org/obo/DOID_2059 vulvar disease A vulvar disease that is characterized by inflammation of the vulva. http://purl.obolibrary.org/obo/DOID_3907 lung squamous cell carcinoma http://purl.obolibrary.org/obo/DOID_1749 squamous cell carcinoma A non-small cell lung carcinoma that has_material_basis_in the squamous cell. http://purl.obolibrary.org/obo/DOID_3908 lung non-small cell carcinoma http://purl.obolibrary.org/obo/DOID_3905 lung carcinoma A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma. http://purl.obolibrary.org/obo/DOID_3911 progeria http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by extreme short stature, low body weight, early loss of hair, lipodystrophy, scleroderma, decreased joint mobility, osteolysis, and facial features that resemble aged persons that has_material_basis_in mutation in LMNA on chromosome 1q22. http://purl.obolibrary.org/obo/DOID_3948 adrenocortical carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma An adrenal cortex cancer that forms in the outer layer of tissue of the adrenal gland and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. http://purl.obolibrary.org/obo/DOID_3950 adrenal carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma An adrenal cancer that is located_in the cortex (steroid hormone-producing tissue) of the adrenal gland and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. http://purl.obolibrary.org/obo/DOID_3953 adrenal gland cancer http://purl.obolibrary.org/obo/DOID_9553 adrenal gland disease An endocrine gland cancer located_in the adrenal glands which are located above the kidneys. http://purl.obolibrary.org/obo/DOID_3969 thyroid gland papillary carcinoma http://purl.obolibrary.org/obo/DOID_0080525 differentiated thyroid gland carcinoma A differentiated thyroid gland carcinoma that is characterized by the small mushroom shape of the tumor which has a stem attached to the epithelial layer abd arises from the follicular cells of the thyroid gland. http://purl.obolibrary.org/obo/DOID_3981 pantothenate kinase-associated neurodegeneration http://purl.obolibrary.org/obo/DOID_0110734 neurodegeneration with brain iron accumulation A neurodegeneration with brain iron accumulation that has_material_basis_in autosomal recessive inheritance of mutation in the PANK2 gene on chromosome 20p13. http://purl.obolibrary.org/obo/DOID_3982 Meige syndrome http://purl.obolibrary.org/obo/DOID_0050845 cranio-facial dystonia A cranio-facial dystonia that is accompanied by blepharospasm. http://purl.obolibrary.org/obo/DOID_3985 ostertagiasis http://purl.obolibrary.org/obo/DOID_1255 trichostrongyloidiasis A trichostrongyloidiasis that involves parasitic infection of the ruminant gastrointestinal tract by nematodes of the genus Ostertagia. http://purl.obolibrary.org/obo/DOID_4006 bladder urothelial carcinoma http://purl.obolibrary.org/obo/DOID_4007 bladder carcinoma A bladder carcinoma that has_material_basis_in transitional cells located_in the lining of the bladder. http://purl.obolibrary.org/obo/DOID_4007 bladder carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A urinary bladder cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. http://purl.obolibrary.org/obo/DOID_401 multidrug-resistant tuberculosis http://purl.obolibrary.org/obo/DOID_399 tuberculosis A tuberculosis that is resistant to isoniazid and rifampicin, the two most powerful first-line anti-TB drugs. http://purl.obolibrary.org/obo/DOID_4012 papillary transitional carcinoma http://purl.obolibrary.org/obo/DOID_2671 transitional cell carcinoma A transitional cell carcinoma that has several papillary fronds with central fibrovascular core lined by transitional type epithelium. http://purl.obolibrary.org/obo/DOID_4022 ureterocele http://purl.obolibrary.org/obo/DOID_1426 ureteral disease A ureteral disease that is characterized_as a congenital anomaly in which the distal end of the ureter swells as it enters the bladder. http://purl.obolibrary.org/obo/DOID_4028 angioma serpiginosum http://purl.obolibrary.org/obo/DOID_471 skin hemangioma A skin hemangioma that is characterized by the presence of small red dots that cluster together to form a linear or snake-like array or ring-shaped pattern located_in the blood vessels of the skin. http://purl.obolibrary.org/obo/DOID_4029 gastritis http://purl.obolibrary.org/obo/DOID_76 stomach disease A stomach disease that is an inflammation of the lining of the stomach. http://purl.obolibrary.org/obo/DOID_4054 prostate sarcoma http://purl.obolibrary.org/obo/DOID_1115 sarcoma A prostate cancer that is located_in the prostate. http://purl.obolibrary.org/obo/DOID_4074 pancreatic adenocarcinoma http://purl.obolibrary.org/obo/DOID_299 adenocarcinoma A pancreatic carcinoma that derives_from epithelial cells of glandular origin. http://purl.obolibrary.org/obo/DOID_4078 tricuspid valve stenosis http://purl.obolibrary.org/obo/DOID_0050826 tricuspid valve disease A tricuspid valve disease that is characterized by the narrowing of the orifice of the tricuspid valve of the heart. This causes increased resistance to blood flow through the valve. http://purl.obolibrary.org/obo/DOID_4080 tricuspid valve insufficiency http://purl.obolibrary.org/obo/DOID_0050826 tricuspid valve disease A tricuspid valve disease that is characterized by failure of the heart's tricuspid valve to close properly during systole. As a result, with each heart beat, blood is pumped out from the right side of the heart in the opposite direction to normal. http://purl.obolibrary.org/obo/DOID_4085 trophoblastic neoplasm http://purl.obolibrary.org/obo/DOID_3095 germ cell and embryonal cancer A germ cell and embryonal cancer that derives_from trophoblastic tissue. http://purl.obolibrary.org/obo/DOID_4140 biliary dyskinesia http://purl.obolibrary.org/obo/DOID_0060262 gallbladder disease A gallbladder disease characterized by altered tonus of the sphincter of Oddi, disturbance in the coordination of contraction of the biliary ducts, and/or reduction in the speed of emptying of the biliary tree. http://purl.obolibrary.org/obo/DOID_4143 orbital cancer http://purl.obolibrary.org/obo/DOID_930 orbital disease A bone cancer that is located_in the area behind the eye and derives_from the orbit or secondarily derives_from an adjacent source (eyelid, paranasal sinus, or intracranial compartment). It results_in the eye pushing forward causing a bulging of the eye called proptosis. http://purl.obolibrary.org/obo/DOID_4156 primary syphilis http://purl.obolibrary.org/obo/DOID_4166 syphilis A syphilis that is the first stage of syphilis, marked by the development of a chancre, which is characterized by mononuclear leukocytic infiltration, macrophages, and lymphocytes. http://purl.obolibrary.org/obo/DOID_4166 syphilis http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that is a sexually transmitted systemic disease, has_material_basis_in Treponema pallidum subsp pallidum, which is transmitted_by sexual contact, transmitted_by blood product transfusion, transmitted_by congenital method from mother to fetus or transmitted_by contact with infectious lesions. If left untreated, produces chancres, rashes, and systemic lesions in a clinical course with three stages continued over many years. http://purl.obolibrary.org/obo/DOID_4189 mutism http://purl.obolibrary.org/obo/DOID_92 speech disorder A speech disorder that involves a complete inability to speak. http://purl.obolibrary.org/obo/DOID_419 scleroderma http://purl.obolibrary.org/obo/DOID_1575 rheumatic disease A rheumatic disease that involves the abnormal growth of connective tissue, which supports the skin and internal organs. http://purl.obolibrary.org/obo/DOID_4202 brain stem glioma http://purl.obolibrary.org/obo/DOID_4203 brain stem cancer A brain stem cancer that is characterized by mass lesion of the brainstem, associated cranial nerve nuclei and long tracts, has_material_basis_in abnormally proliferating cells, derives_from glial cells. http://purl.obolibrary.org/obo/DOID_421 hair disease http://purl.obolibrary.org/obo/DOID_16 integumentary system disease An integumentary system disease that is located_in hair. http://purl.obolibrary.org/obo/DOID_4217 malignant ovarian Brenner tumor http://purl.obolibrary.org/obo/DOID_2151 malignant ovarian surface epithelial-stromal neoplasm A malignant ovarian surface epithelial-stromal neoplasm that has_material_basis_in the surface epithelium of the ovary. http://purl.obolibrary.org/obo/DOID_4226 endometrial stromal sarcoma http://purl.obolibrary.org/obo/DOID_5166 endometrial stromal tumor An endometrial stromal tumor that has_material_basis in connective tissue. http://purl.obolibrary.org/obo/DOID_4232 extraosseous Ewing sarcoma http://purl.obolibrary.org/obo/DOID_3369 Ewing sarcoma A Ewing sarcoma that is morphologically indistinguishable from skeletal Ewing sarcoma but is located in extraosseous locations. http://purl.obolibrary.org/obo/DOID_4233 clear cell sarcoma http://purl.obolibrary.org/obo/DOID_1115 sarcoma A sarcoma that is characterized by solid nests and fascicles of tumor cells with clear cytoplasm and prominent nucleoli. It presents as a slow growing mass that especially affects tendons and aponeuroses and it is deeply situated. http://purl.obolibrary.org/obo/DOID_4235 spindle cell sarcoma http://purl.obolibrary.org/obo/DOID_1115 sarcoma A sarcoma that results_in cells that are spindle-shaped. They are usually resistant to radiation therapy. http://purl.obolibrary.org/obo/DOID_4236 carcinosarcoma http://purl.obolibrary.org/obo/DOID_154 mixed cell type cancer A mixed cell type cancer that has_material_basis_in carcinomatous (epithelial tissue) and sarcomatous (connective tissue) components. http://purl.obolibrary.org/obo/DOID_4239 alveolar soft part sarcoma http://purl.obolibrary.org/obo/DOID_4043 skeletal muscle cancer A soft tissue cancer that is a slow growing tumor of an unknown origin that effects children and effects young adults. http://purl.obolibrary.org/obo/DOID_424 pulmonary immaturity http://purl.obolibrary.org/obo/DOID_850 lung disease A lung disease that is characterized by pulmonary collapse, accompanied by hypoventilation which can affect a lobe, segment, or all of the lung, resulting in a decrease in the ventilation/perfusion ratio. http://purl.obolibrary.org/obo/DOID_4242 kidney sarcoma http://purl.obolibrary.org/obo/DOID_263 kidney cancer A kidney cancer that is located in the kidney's connective tissue. http://purl.obolibrary.org/obo/DOID_4249 Gerstmann-Straussler-Scheinker syndrome http://purl.obolibrary.org/obo/DOID_649 prion disease A prion disease characterized by adult onset of memory loss, dementia, ataxia, and pathologic deposition of amyloid-like plaques in the brain. http://purl.obolibrary.org/obo/DOID_4252 Alexander disease http://purl.obolibrary.org/obo/DOID_10579 leukodystrophy A leukodystrophy that is characterized by the destruction of white matter and the formation of Rosenthal fibers consisting of abnormal clumps of protein that accumulate in astrocytes. http://purl.obolibrary.org/obo/DOID_4253 melorheostosis http://purl.obolibrary.org/obo/DOID_4254 osteosclerosis An osteosclerosis that has_material_basis_in a mutation of the LEMD3 gene which results_in a hyperdense bony cortex. http://purl.obolibrary.org/obo/DOID_4257 Caffey disease http://purl.obolibrary.org/obo/DOID_3342 bone inflammation disease A bone inflammation disease that causes bone changes, soft tissue swelling and irritability in infants. The disease has been associated with COL1A1 gene. It has symptom soft-tissue swelling, has symptom bone lesions, and has symptom irritability. http://purl.obolibrary.org/obo/DOID_4267 akinetic mutism http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease characterized by marked reduction of nearly all motor functions including facial expressions, gestures and speech output, but with some degree of alertness. http://purl.obolibrary.org/obo/DOID_4270 encephalitozoonosis http://purl.obolibrary.org/obo/DOID_4271 microsporidiosis A microsporidiosis that is a zoonotic infectious disease results_in disseminated fungal infection in dogs, cats, hamsters, guinea pigs, rats, mice and humans, has_material_basis_in Encephalitozoon cuniculi, has_material_basis_in Encephalitozoon intestinalis or has_material_basis_in Encephalitozoon hellem. http://purl.obolibrary.org/obo/DOID_4271 microsporidiosis http://purl.obolibrary.org/obo/DOID_2473 opportunistic mycosis An opportunistic mycosis that results_in systemic fungal infection in immunocompromised people, has_material_basis_in Microsporidia phylum members. http://purl.obolibrary.org/obo/DOID_4280 nodular basal cell carcinoma http://purl.obolibrary.org/obo/DOID_2513 basal cell carcinoma A basal cell carcinoma characterized by elevated, pearl shaped nodules with telengactisae on the surface and periphery. http://purl.obolibrary.org/obo/DOID_4288 external ear carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma An external ear cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. http://purl.obolibrary.org/obo/DOID_4297 scimitar syndrome http://purl.obolibrary.org/obo/DOID_1682 congenital heart disease A congenital heart disease that is characterized by partial or entire anomalous curved venous drainage of the right lung to the inferior vena cava, association with variable right lung and pulmonary artery hypoplasia, dextraposition of the heart and an anomalous systemic blood supply to the ipsilateral lung. http://purl.obolibrary.org/obo/DOID_4305 bone giant cell tumor http://purl.obolibrary.org/obo/DOID_200 benign giant cell tumor A benign giant cell tumor that results_in the presence of multinucleated giant cells. http://purl.obolibrary.org/obo/DOID_4306 radiculopathy http://purl.obolibrary.org/obo/DOID_574 peripheral nervous system disease A peripheral nervous system disease that is characterized by the pinching of a nerve root in the spine and has symptoms of pain, weakness, numbness and tingling. http://purl.obolibrary.org/obo/DOID_4313 epidermolysis bullosa acquisita http://purl.obolibrary.org/obo/DOID_0060039 autoimmune disease of skin and connective tissue An acquired epidermolysis bullosa that is characterized by formation of recurrent blisters secondary to minor trauma in the skin and mucosa, and has_material_basis_in the development of autoantibodies to type VII collagen. http://purl.obolibrary.org/obo/DOID_4325 Ebola hemorrhagic fever http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Zaire ebolavirus, has_material_basis_in Sudan ebolavirus, has_material_basis_in Cote d'Ivoire ebolavirus, or has_material_basis_in Bundibugyo ebolavirus, which are transmitted_by contact with the body fluids of an infected animal or person, transmitted by contaminated fomites, or transmitted by infected medical equipment. The infection has_symptom fever, has_symptom headache, has_symptom joint pain, has_symptom muscle aches, has_symptom sore throat, has_symptom weakness, has_symptom diarrhea, has_symptom vomiting, has_symptom stomach pain, has_symptom rash, has_symptom red eyes, has_symptom hiccups, and has_symptom internal and external bleeding. http://purl.obolibrary.org/obo/DOID_4327 Marburg hemorrhagic fever http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Marburgvirus, which is transmitted_by contact with the body fluids of an infected person. The infection has_symptom fever, has_symptom chills, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash on the trunk, has_symptom nausea, has_symptom vomiting, has_symptom chest pain, has_symptom sore throat, has_symptom abdominal pain, has_symptom diarrhea, and has_symptom bleeding. http://purl.obolibrary.org/obo/DOID_4333 parovarian cyst http://purl.obolibrary.org/obo/DOID_229 female reproductive system disease A female reproductive system disease that is characterized by epithelium-lined fluid-filled cysts in the adnexa adjacent to the fallopian tube and ovary. http://purl.obolibrary.org/obo/DOID_4336 tinea favosa http://purl.obolibrary.org/obo/DOID_4337 tinea capitis A tinea capitis that results_in fungal infection located_in scalp, located_in glabrous skin or located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and results_in_formation_of scutula, yellowish cup-shaped crusts of dense masses of mycelium and epithelial debris, which develop at the surface of a hair follicle with the shaft in the center of the raised lesion. Removal of these crusts reveals an oozing, moist, red base. Later, atrophy of the skin occurs leaving a cicatricial alopecia and scarring. http://purl.obolibrary.org/obo/DOID_4362 cervical cancer http://purl.obolibrary.org/obo/DOID_363 uterine cancer A female reproductive organ cancer that is located_in the cervix. http://purl.obolibrary.org/obo/DOID_4367 apparent mineralocorticoid excess syndrome http://purl.obolibrary.org/obo/DOID_630 genetic disease A steroid inherited metabolic disorder characterized by decreased conversion of biologically active cortisol to inactive cortisone resulting in low aldosterone levels, metabolic alkalosis, hypernatremia, hypokalemia and early-onset severe hypertension that has_material_basis_in homozygous or compound heterozygous mutation in the HSD11B2 gene on chromosome 16. http://purl.obolibrary.org/obo/DOID_4371 Schnitzler syndrome http://purl.obolibrary.org/obo/DOID_2916 hypersensitivity reaction type IV disease A hypersensitivity reaction type IV disease that is characterized by chronic urticarial rash and monoclonal IgM gammopathy, has_symptom rash, intermittent fever, arthralgia, and lymphadenopathy. http://purl.obolibrary.org/obo/DOID_4378 peanut allergy http://purl.obolibrary.org/obo/DOID_0060904 legume allergy A legume allergy that is an allergy or hypersensitivity to dietary substances from peanuts causing an overreaction of the immune system which in a small percentage of people may lead to severe physical symptoms. http://purl.obolibrary.org/obo/DOID_4411 hepatitis E http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis E virus, which is transmitted_by ingestion of contaminated food. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom dark urine, has_symptom joint pain, and has_symptom jaundice. http://purl.obolibrary.org/obo/DOID_4423 sea-blue histiocytosis http://purl.obolibrary.org/obo/DOID_1927 sphingolipidosis A sphingolipidosis characterized by dysfunctional metabolism of sphingolipids. http://purl.obolibrary.org/obo/DOID_4428 dyslexia http://purl.obolibrary.org/obo/DOID_13365 reading disorder A reading disorder resulting from a developmental reading disability involving the inability to process graphic symbols resulting in impairment of reading ability. http://purl.obolibrary.org/obo/DOID_4439 central nervous system germ cell tumor http://purl.obolibrary.org/obo/DOID_3620 central nervous system cancer A central nervous system cancer that is characterized by tumors near the pineal gland, the pituitary gland and the tissue just above it, develops from mismigrational pluripotent embryonic cells that remain in the brain after birth, has_material_basis_in abnormally proliferating cells derives_from germ cells. http://purl.obolibrary.org/obo/DOID_4440 seminoma http://purl.obolibrary.org/obo/DOID_2994 germ cell cancer A germinoma that has_material_basis_in cells that make sperm and eggs. http://purl.obolibrary.org/obo/DOID_4441 dysgerminoma http://purl.obolibrary.org/obo/DOID_2394 ovarian cancer A germ cell cancer that derives_from cells that give rise to egg cells. http://purl.obolibrary.org/obo/DOID_4450 renal cell carcinoma http://purl.obolibrary.org/obo/DOID_4451 renal carcinoma A renal carcinoma that has_material_basis_in the lining of the proximal convoluted renal tubule of the kidney. http://purl.obolibrary.org/obo/DOID_4451 renal carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A kidney cancer that derives_from the lining of the proximal convoluted tubule (the very small tubes in the kidney that filter the blood and remove waste products). http://purl.obolibrary.org/obo/DOID_4464 collecting duct carcinoma http://purl.obolibrary.org/obo/DOID_4450 renal cell carcinoma A renal cell carcinoma that begins in distal collecting ducts of the kidney with a tubulopapillary morphology and intracytoplasmic mucicarminophilic material. http://purl.obolibrary.org/obo/DOID_4465 papillary renal cell carcinoma http://purl.obolibrary.org/obo/DOID_4450 renal cell carcinoma A renal cell carcinoma that is characterized by the development of multiple, bilateral papillary renal tumors. http://purl.obolibrary.org/obo/DOID_4467 clear cell renal cell carcinoma http://purl.obolibrary.org/obo/DOID_4450 renal cell carcinoma A renal cell carcinoma that has_material_basis_in cells that appear very pale or clear when examined under microscope. http://purl.obolibrary.org/obo/DOID_4468 clear cell adenocarcinoma http://purl.obolibrary.org/obo/DOID_299 adenocarcinoma An adenocarcinoma that derives_from epithelial cells which have clear cytoplasm. http://purl.obolibrary.org/obo/DOID_4471 chromophobe renal cell carcinoma http://purl.obolibrary.org/obo/DOID_4450 renal cell carcinoma A renal cell carcinoma that has_material_basis_in chromophobe cell that appear pale when viewed under microscope, but that are larger and display different features than clear cells. http://purl.obolibrary.org/obo/DOID_4480 achondroplasia http://purl.obolibrary.org/obo/DOID_2256 osteochondrodysplasia An osteochondrodysplasia that results_in dwarfism which has_material_basis_in abnormal ossification of cartilage in located_in long bone. http://purl.obolibrary.org/obo/DOID_4481 allergic rhinitis http://purl.obolibrary.org/obo/DOID_0060496 respiratory allergy A rhinitis that is an allergic inflammation and irritation of the nasal airways involving sneezing, runny nose, nasal congestion, itching and tearing of the eyes caused by exposure to an allergen such as pollen, dust, mold, animal dander and droppings of cockroaches or house dust mites. http://purl.obolibrary.org/obo/DOID_4483 rhinitis http://purl.obolibrary.org/obo/DOID_2163 nasal cavity disease A upper respiratory infectious disease which involves irritation and inflammation of the mucous membrane of the nose due to viruses, bacteria or irritants. The inflammation results in generation of excessive amounts of mucus leading to runny nose, as well as nasal congestion and post-nasal drip. http://purl.obolibrary.org/obo/DOID_4492 avian influenza http://purl.obolibrary.org/obo/DOID_8469 influenza An influenza that results in infection located in respiratory tract of humans, domestic and wild birds, has_material_basis_in Influenza A virus, which is transmitted by contact with infected poultry. Five strains of avian influenza A viruses (H5N1, H7N3, H7N2, H7N7 and H9N2) are known to cause human infections. The infection has_symptom fever, has_symptom cough, has_symptom sore throat, has_symptom muscle aches, has_symptom nausea, has_symptom diarrhea, has_symptom vomiting, has_symptom neurologic changes, has_symptom pneumonia, and has_symptom acute respiratory distress. http://purl.obolibrary.org/obo/DOID_452 pleomorphic adenoma http://purl.obolibrary.org/obo/DOID_0050624 gastrointestinal system benign neoplasm A gastrointestinal system benign neoplasm that is a located_in the salivary glands. http://purl.obolibrary.org/obo/DOID_4534 Hallermann-Streiff syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that affects growth, cranial development, hair growth and dental development. http://purl.obolibrary.org/obo/DOID_4540 dysgraphia http://purl.obolibrary.org/obo/DOID_0060047 writing disorder A writing disorder that involves a deficiency in the ability to write where the writing is distorted or incorrect, spelling difficulty, poor handwriting or trouble putting thoughts on paper. http://purl.obolibrary.org/obo/DOID_4543 retrograde amnesia http://purl.obolibrary.org/obo/DOID_10914 amnestic disorder An amnestic disorder that involves a loss of one's pre-existing memories to conscious recollection. http://purl.obolibrary.org/obo/DOID_4549 extraosseous chondrosarcoma http://purl.obolibrary.org/obo/DOID_3371 chondrosarcoma A chondrosarcoma that is located_in exclusively soft tissue. http://purl.obolibrary.org/obo/DOID_456 ascariasis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that involves infection of the intestine with the nematode Ascaris lumbricoides. Larvae migrating through the lungs cause cough, wheezing and hemoptysis. Bowel or biliary obstruction causes cramping abdominal pain, nausea, and vomiting. Peritonitis, enlargement of the liver or spleen, toxicity and pneumonia are observed when larvae get into the portal circulation. http://purl.obolibrary.org/obo/DOID_4607 biliary tract cancer http://purl.obolibrary.org/obo/DOID_0080355 hepatobiliary system cancer A hepatobiliary system cancer that results_in malignant growth located_in the gallbladder or located_in the bile duct. http://purl.obolibrary.org/obo/DOID_4621 holoprosencephaly http://purl.obolibrary.org/obo/DOID_2490 congenital nervous system abnormality A congenital nervous system abnormality characterized by failed or incomplete separation of the forebrain early in gestation; it is accompanied by a spectrum of characteristic craniofacial anomalies. http://purl.obolibrary.org/obo/DOID_4624 Ollier disease http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by an asymmetric distribution of cartilagenous tumors, which may lead to skeletal deformities and limb-length discrepancy. This condition primarily affects the long bones and cartilage of the joints of the arms and legs, specifically the area where the shaft and head of a long bone meet. http://purl.obolibrary.org/obo/DOID_4650 bilateral retinoblastoma http://purl.obolibrary.org/obo/DOID_768 retinoblastoma A retinoblastoma that develops in both eyes. http://purl.obolibrary.org/obo/DOID_4661 multiple chemical sensitivity http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is an adverse physical reaction to low levels of many common chemicals. http://purl.obolibrary.org/obo/DOID_4674 androgen insensitivity syndrome http://purl.obolibrary.org/obo/DOID_1923 disorder of sexual development A disorder of sexual developement that is characterized by the inability of the cell to respond to androgens in individuals with a karyotype of 46,XY resulting in female physical traits but male genetic makeup. http://purl.obolibrary.org/obo/DOID_4680 breast metaplastic carcinoma http://purl.obolibrary.org/obo/DOID_3459 breast carcinoma A breast carcinoma that represents a mixed group of malignant neoplasms characterized by the histologic presence of two or more cellular types. http://purl.obolibrary.org/obo/DOID_4692 endophthalmitis http://purl.obolibrary.org/obo/DOID_1242 globe disease A globe disease that is characterized by inflammation of the inside of the eye. http://purl.obolibrary.org/obo/DOID_4723 intracranial hypotension http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is characterized by low pressure inside the skull, and thus in the brain tissue and cerebrospinal fluid; may occur as a result of an occult or iatrogenically caused leak of CSF into another body cavity; may result in the downward displacement of the cerebellar tonsils through the foramen magnum or Chiari malformation; has_symptom orthostatic headache; other symptoms are related to compression of cranial nerves due to brain sagging. http://purl.obolibrary.org/obo/DOID_4724 brain edema http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is characterized by excess accumulation of fluid in the intracellular and/or extracellular spaces of the brain, has_symptom nausea, has_symptom vomiting, has_symptom blurred vision, has_symptom seizure, has_symptom coma. http://purl.obolibrary.org/obo/DOID_4744 placenta accreta http://purl.obolibrary.org/obo/DOID_780 placenta disease A placenta disease that is characterized by an abnormally deep attachment of the placenta, through the endometrium and into the myometrium. http://purl.obolibrary.org/obo/DOID_4765 pulmonary blastoma http://purl.obolibrary.org/obo/DOID_1532 pleural disease A lung cancer that has_material_basis_in tissues of the lung and has_material_basis_in pleural tissues. It is most commonly effects children. http://purl.obolibrary.org/obo/DOID_4769 pleuropulmonary blastoma http://purl.obolibrary.org/obo/DOID_4765 pulmonary blastoma A pulmonary blastoma that derives_from the lung or pleural cavity. http://purl.obolibrary.org/obo/DOID_4773 congenital mesoblastic nephroma http://purl.obolibrary.org/obo/DOID_0080015 physical disorder A kidney cancer that is characterized by the presence of fibroblastic cells. http://purl.obolibrary.org/obo/DOID_4810 cerebrotendinous xanthomatosis http://purl.obolibrary.org/obo/DOID_3345 xanthomatosis A xanthomatosis that is characterized by a deficiency in the production of the bile acid, chenodeoxycholic acid that has_material_basis_in autosomal recessive inheritance and results in cholestanol deposition in the brain and other tissues and with elevated levels of cholesterol in plasma. http://purl.obolibrary.org/obo/DOID_4817 ganglioneuroma http://purl.obolibrary.org/obo/DOID_0080321 autonomic nervous system benign neoplasm An autonomic nervous system benign neoplasm that is characterized by the presence of mature ganglion cells and a mature Schwannian stroma and arises from the sympathetic trunk in the mediastinum. http://purl.obolibrary.org/obo/DOID_4830 adenosquamous carcinoma http://purl.obolibrary.org/obo/DOID_1749 squamous cell carcinoma A squamous cell carcinoma that contains squamous cells and gland-like cells. http://purl.obolibrary.org/obo/DOID_4837 Gorham's disease http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by bone loss (osteolysis) which is often associated with swelling or abnormal blood vessel growth (angiomatous proliferation). Bone loss can occur in just one bone or spread to soft tissue and adjacent bones. http://purl.obolibrary.org/obo/DOID_4838 myoepithelial carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A carcinoma that derives_from myoepithelial cells. http://purl.obolibrary.org/obo/DOID_4851 pilocytic astrocytoma http://purl.obolibrary.org/obo/DOID_0080830 pediatric low-grade glioma A pediatric low-grade glioma that is characterized by cells that look like fibers when viewed under a microscope and is located_in the brain. http://purl.obolibrary.org/obo/DOID_4885 Colorado tick fever http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in infection, has_material_basis_in Colorado tick fever virus, which is transmitted_by rocky mountain wood tick, Dermacentor andersoni. The infection has_symptom fever for 2-3 days, followed by an afebrile period of similar duration and then another 2-3 days of fever, has_symptom headache, has_symptom myalgia, and has_symptom fatigue. http://purl.obolibrary.org/obo/DOID_4889 lymph node tuberculosis http://purl.obolibrary.org/obo/DOID_9942 lymph node disease An extrapulmonary tuberculosis that is located_in lymph node, and has_symptom lymphadenopathy, has_symptom fever, has_symptom weight loss, has_symptom fatigue, has_symptom night sweats and has_symptom cough. http://purl.obolibrary.org/obo/DOID_4896 bile duct adenocarcinoma http://purl.obolibrary.org/obo/DOID_299 adenocarcinoma A bile duct carcinoma that derives_from epithelial cells of glandular origin. http://purl.obolibrary.org/obo/DOID_4897 bile duct carcinoma http://purl.obolibrary.org/obo/DOID_4606 bile duct cancer A bile duct cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. http://purl.obolibrary.org/obo/DOID_4902 appendix carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma An appendix cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. http://purl.obolibrary.org/obo/DOID_4905 pancreatic carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A pancreas cancer that derives_from epithelial cells located_in the pancreas. http://purl.obolibrary.org/obo/DOID_4907 small intestine carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A small intestine cancer that develops from epithelial cells and is located_in the small intestine. http://purl.obolibrary.org/obo/DOID_4908 anal carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A anus cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is located_in the anus. http://purl.obolibrary.org/obo/DOID_4923 thymus adenocarcinoma http://purl.obolibrary.org/obo/DOID_299 adenocarcinoma A thymic carcinoma that derives_from epithelial cells of glandular origin. http://purl.obolibrary.org/obo/DOID_4927 Klatskin's tumor http://purl.obolibrary.org/obo/DOID_4928 intrahepatic cholangiocarcinoma An intrahepatic cholangiocarcinoma arising near or at the confluence of the right and left hepatic ducts. http://purl.obolibrary.org/obo/DOID_4932 ampulla of Vater carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma An ampulla of Vater cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. http://purl.obolibrary.org/obo/DOID_4943 adenocarcinoma in situ http://purl.obolibrary.org/obo/DOID_8719 in situ carcinoma An in situ carcinoma that derives_from epithelial cells of glandular origin. http://purl.obolibrary.org/obo/DOID_4947 cholangiocarcinoma http://purl.obolibrary.org/obo/DOID_4896 bile duct adenocarcinoma A bile duct adenocarcinoma that has_material_basis_in bile duct epithelial cells. http://purl.obolibrary.org/obo/DOID_4948 gallbladder carcinoma http://purl.obolibrary.org/obo/DOID_3121 gallbladder cancer A gallbladder cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. http://purl.obolibrary.org/obo/DOID_4964 neurotic disorder http://purl.obolibrary.org/obo/DOID_2030 anxiety disorder An anxiety disorder that involves discress but neither delusions nor hallucinations. http://purl.obolibrary.org/obo/DOID_4970 prosopagnosia http://purl.obolibrary.org/obo/DOID_4090 agnosia An agnosia that results in the loss of the ability to consciously recognize familiar faces. http://purl.obolibrary.org/obo/DOID_4971 myelofibrosis http://purl.obolibrary.org/obo/DOID_0070004 myeloid neoplasm A myeloid neoplasm that is located in the bone marrow which results in bone marrow being replaced by fibrous (scar) tissue. http://purl.obolibrary.org/obo/DOID_4974 actinobacillosis http://purl.obolibrary.org/obo/DOID_1579 respiratory system disease A commensal bacterial infectious disease that results_in infection, has_material_basis_in Actinobacillus ureae, which is a commensal of the human respiratory tract. The pathogen causes meningitis, endocarditis, bacteremia, atrophic rhinitis, bronchitis, pneumonia, conjunctivitis, peritonitis, and otitis media. http://purl.obolibrary.org/obo/DOID_4990 essential tremor http://purl.obolibrary.org/obo/DOID_480 movement disease A movement disorder that causes involuntary tremors, especially in the hands. It occurs alone without other neurological signs and symptoms. http://purl.obolibrary.org/obo/DOID_4997 Camurati-Engelmann disease http://purl.obolibrary.org/obo/DOID_4254 osteosclerosis An osteosclerosis that has_material_basis_in mutations in the TGFB1 gene which results_in increased bone density located_in long bone. http://purl.obolibrary.org/obo/DOID_5015 fibrolamellar carcinoma http://purl.obolibrary.org/obo/DOID_684 hepatocellular carcinoma A hepatocellular carcinoma characterized microscopically by laminated fibrous layers interspersed between the tumour cells. The polygonal, deeply eosinophilic tumor cells arise in non-cirrhotic livers. http://purl.obolibrary.org/obo/DOID_502 central nervous system mesenchymal non-meningothelial tumor http://purl.obolibrary.org/obo/DOID_3620 central nervous system cancer A central nervous system cancer that is characterized by mesenchymal tumors within the CNS that develops from meninges, has_material_basis_in abnormally proliferating cells derives_from mesoderm. http://purl.obolibrary.org/obo/DOID_5052 melioidosis http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that results_in infection, has_material_basis_in Burkholderia pseudomallei, which is transmitted_by contact with the contaminated water or soil. The infection has_symptom fever, has_symptom respiratory distress, has_symptom chest pain, and has_symptom stomach pain. http://purl.obolibrary.org/obo/DOID_5062 phencyclidine abuse http://purl.obolibrary.org/obo/DOID_302 substance abuse A substance abuse that involves the recurring use of phencyclidine (PCP) drugs despite negative consequences. http://purl.obolibrary.org/obo/DOID_507 adjustment disorder http://purl.obolibrary.org/obo/DOID_150 disease of mental health A disease of mental health that is an abnormal and excessive emotional and behavioral reaction to a life stress that develops within 3 months of a life stress, and which is stronger or greater than what would be expected for the type of event that occurred. http://purl.obolibrary.org/obo/DOID_5074 malignant ependymoma http://purl.obolibrary.org/obo/DOID_3541 cerebral ventricle cancer A malignant glioma that is derived from ependymal cells, a type of glial cell, located_in ventricle lining within the central part of the brain. http://purl.obolibrary.org/obo/DOID_5078 ganglioglioma http://purl.obolibrary.org/obo/DOID_0060090 central nervous system benign neoplasm A cell type benign neoplasm that has_material_basis_in glial-type cells. http://purl.obolibrary.org/obo/DOID_5112 copper deficiency myelopathy http://purl.obolibrary.org/obo/DOID_5113 nutritional deficiency disease A nutritional deficiency disease that is characterized by deficiency of copper, causing spastic gait and ataxia, often with anemia and neutropenia, has_symptom imbalance and jerking movements, and has_material_basis_in copper deficiency possibly due to malabsorption or excess zinc ingestion. http://purl.obolibrary.org/obo/DOID_5138 leiomyomatosis http://purl.obolibrary.org/obo/DOID_127 leiomyoma A leiomyoma that is multiple and diffuse. http://purl.obolibrary.org/obo/DOID_5142 vulvar leiomyoma http://purl.obolibrary.org/obo/DOID_0060109 vulvar benign neoplasm A vulvar benign neoplasm that is located_in smooth muscle cells. http://purl.obolibrary.org/obo/DOID_5154 borna disease http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in infection, which affects dopaminergic neurotransmission located_in central nervous system, has_material_basis_in Borna disease virus, which is transmitted_by contact with infected oronasal secretions. The infection has_symptom mood disturbances, has_symptom behaviour disturbances, has_symptom cognitive disturbances, has_symptom neurologic disturbances, and has_symptom movement impairment. http://purl.obolibrary.org/obo/DOID_5162 arteriolosclerosis http://purl.obolibrary.org/obo/DOID_2349 arteriosclerosis An arteriosclerosis that is characterized by thickening of the wall of the small arteries and arterioles, caused by deposition of hyaline material in the wall or concentric smooth muscle wall hypertrophy, and results in lumen narrowing and tissue ischemia. http://purl.obolibrary.org/obo/DOID_5183 hereditary Wilms' tumor http://purl.obolibrary.org/obo/DOID_2154 nephroblastoma A nephroblastoma that results_in either bilateral disease or a family history of Wilms' tumour. http://purl.obolibrary.org/obo/DOID_5204 fructose-1,6-bisphosphatase deficiency http://purl.obolibrary.org/obo/DOID_2978 carbohydrate metabolic disorder A carbohydrate metabolic disorder that has_material_basis_in a deficiency of fructose-1,6-bisphosphatase resulting in hypoglycemia and metabolic acidosis on fasting due to insufficient fructose bisphosphatase for gluconeogenesis. http://purl.obolibrary.org/obo/DOID_5207 monodermal teratoma http://purl.obolibrary.org/obo/DOID_5567 ovarian germ cell teratoma An ovarian germ cell teratoma that has_material_basis_in a tissue type from one germ cell layer (ectoderm, mesoderm or endoderm). http://purl.obolibrary.org/obo/DOID_5213 chronic inflammatory demyelinating polyradiculoneuropathy http://purl.obolibrary.org/obo/DOID_0060033 autoimmune disease of peripheral nervous system An autoimmune disease of peripheral nervous system that is characterized by inflammation of nerve roots and peripheral nerves and destruction of the fatty protective covering (myelin sheath) over the nerves. This affects how fast the nerve signals are transmitted and leads to loss of nerve fibers. http://purl.obolibrary.org/obo/DOID_526 human immunodeficiency virus infectious disease http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands. http://purl.obolibrary.org/obo/DOID_5272 small intestinal sarcoma http://purl.obolibrary.org/obo/DOID_10154 small intestine cancer A sarcoma and malignant tumor of small intestine that is located_in the small intestine. http://purl.obolibrary.org/obo/DOID_5282 prostate leiomyosarcoma http://purl.obolibrary.org/obo/DOID_4054 prostate sarcoma A prostate sarcoma that is located_in the prostate. http://purl.obolibrary.org/obo/DOID_5285 breast leiomyosarcoma http://purl.obolibrary.org/obo/DOID_3017 breast sarcoma A breast sarcoma that arises from smooth muscle cells. http://purl.obolibrary.org/obo/DOID_5287 kidney leiomyosarcoma http://purl.obolibrary.org/obo/DOID_4242 kidney sarcoma A leiomyosarcoma and sarcoma of kidney that is located_in the kidney. http://purl.obolibrary.org/obo/DOID_529 blepharospasm http://purl.obolibrary.org/obo/DOID_0050836 focal dystonia A focal dystonia that is characterized by the involuntary, forcible contraction of the muscles controlling eye blinks. http://purl.obolibrary.org/obo/DOID_5304 ovarian clear cell adenocarcinoma http://purl.obolibrary.org/obo/DOID_3713 ovary adenocarcinoma A ovarian adenocarcinoma that derives_from epithelial cells which have clear cytoplasm. http://purl.obolibrary.org/obo/DOID_5325 Roberts syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by tetraphocomelia, craniofacial anomalies, growth retardation, intellectual disability, and cardiac and renal abnormalities that has_material_basis_in homozygous or compound heterozygous mutation in ESCO2 on chromosome 8p21.1. http://purl.obolibrary.org/obo/DOID_5363 myxoid liposarcoma http://purl.obolibrary.org/obo/DOID_3382 liposarcoma A liposarcoma that is characterized by the presence of a hypocellular spindle cell proliferation set in a myxoid background and has_material_basis_in chromosomal translocations. http://purl.obolibrary.org/obo/DOID_5381 bile duct adenoma http://purl.obolibrary.org/obo/DOID_657 adenoma A biliary tract benign neoplasm that results_in a small firm white nodule with multiple bile ducts that are located_in a fibrous stroma. http://purl.obolibrary.org/obo/DOID_5386 lung adenoma http://purl.obolibrary.org/obo/DOID_657 adenoma A lung benign neoplasm that derives_from glandular epithelial cells. http://purl.obolibrary.org/obo/DOID_5387 middle ear adenoma http://purl.obolibrary.org/obo/DOID_5100 middle ear disease A sensory organ benign neoplasm that is located_in the middle ear. http://purl.obolibrary.org/obo/DOID_5398 lipoadenoma http://purl.obolibrary.org/obo/DOID_657 adenoma An adenoma that is composed_of epithelial cells admixed with adipose tissue cells. http://purl.obolibrary.org/obo/DOID_5403 microcystic adenoma http://purl.obolibrary.org/obo/DOID_0060084 cell type benign neoplasm A pancreatic cystadenoma that is characterized by innumerable small cysts lined by bland clear cells. http://purl.obolibrary.org/obo/DOID_5408 Paget's disease of bone http://purl.obolibrary.org/obo/DOID_205 hyperostosis A bone formation disease that has_material_basis_in hyperactive osteoclast which results_in abnormal osteoblast bone formation located_in skull, located_in pelvis, located_in vertebral column, located_in set of limbs. http://purl.obolibrary.org/obo/DOID_5418 schizoaffective disorder http://purl.obolibrary.org/obo/DOID_2468 psychotic disorder A psychotic disorder that is characterized by recurring episodes of mood fluctuations and a loss of contact with reality. http://purl.obolibrary.org/obo/DOID_5425 ovarian hyperstimulation syndrome http://purl.obolibrary.org/obo/DOID_1100 ovarian disease An ovarian disease that is characterized by cystic enlargement of the ovaries and a fluid shift from the intravascular to the third space and has_symptom abdominal pain, has_symptom nausea and has_symptom vomiting. This disease is an iatrogenic complication of assisted reproduction technology. http://purl.obolibrary.org/obo/DOID_5426 premature ovarian failure http://purl.obolibrary.org/obo/DOID_1100 ovarian disease An ovarian disease where ovaries do not produce estrogen despite high levels of circulating gonadotropins in women under 40. http://purl.obolibrary.org/obo/DOID_5468 biliary papillomatosis http://purl.obolibrary.org/obo/DOID_2615 papilloma A biliary tract benign neoplasm characterized by multiple papillary tumors in the intrahepatic and/or extrahepatic biliary tree. http://purl.obolibrary.org/obo/DOID_5482 cystadenofibroma http://purl.obolibrary.org/obo/DOID_0060112 ovarian benign neoplasm An ovarian benign neoplasm that is composed_of epithelial ovarian tissue. http://purl.obolibrary.org/obo/DOID_5485 synovial sarcoma http://purl.obolibrary.org/obo/DOID_2706 synovium cancer A synovium cancer which develops in the synovial membrane of the joints. http://purl.obolibrary.org/obo/DOID_5503 spinal cord ependymoma http://purl.obolibrary.org/obo/DOID_3185 spinal cord glioma A spinal cord glioma that has_material_basis_in cells linking the spinal cord central canal. http://purl.obolibrary.org/obo/DOID_5515 nasal cavity squamous cell carcinoma http://purl.obolibrary.org/obo/DOID_1749 squamous cell carcinoma A nasal cavity carcinoma that has_material_basis_in squamous cells. http://purl.obolibrary.org/obo/DOID_5517 stomach carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A stomach cancer that is located_in the stomach. http://purl.obolibrary.org/obo/DOID_5522 basaloid squamous cell carcinoma http://purl.obolibrary.org/obo/DOID_1749 squamous cell carcinoma A squamous cell carcinoma that has a solid, closely packed growth of cells with hyperchromatic nuclei, scant cytoplasm, small cystic spaces, and foci of necrosis. It has overlying squamous dysplasia, rare foci of overt keratinization, and/or coexistent keratinizing squamous cell carcinoma. http://purl.obolibrary.org/obo/DOID_5525 anal squamous cell carcinoma http://purl.obolibrary.org/obo/DOID_1749 squamous cell carcinoma An anal carcinoma that arises near the squamocolumnar junction. http://purl.obolibrary.org/obo/DOID_5535 gallbladder squamous cell carcinoma http://purl.obolibrary.org/obo/DOID_1749 squamous cell carcinoma A squamous cell carcinoma that is located_in the gallbladder. http://purl.obolibrary.org/obo/DOID_5566 mature teratoma http://purl.obolibrary.org/obo/DOID_3307 teratoma A teratoma that is composed exclusively of mature tissues derived from two or three germ layers. http://purl.obolibrary.org/obo/DOID_5572 Beckwith-Wiedemann syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by overgrowth (macrosomia), an increased risk of childhood cancer and congenital malformations. http://purl.obolibrary.org/obo/DOID_5577 gastrinoma http://purl.obolibrary.org/obo/DOID_169 neuroendocrine tumor A neuroendocrine tumor that results_in an overproduction of gastric acid. http://purl.obolibrary.org/obo/DOID_5592 breast papillary carcinoma http://purl.obolibrary.org/obo/DOID_3459 breast carcinoma A breast carcinoma that is characterized by the presence of arborescent fibrovascular stalks lined by epithelial cells, grossly forming a circumscribed mass. http://purl.obolibrary.org/obo/DOID_5603 T-cell acute lymphoblastic leukemia http://purl.obolibrary.org/obo/DOID_9952 acute lymphoblastic leukemia An acute lymphoblastic leukemia that is characterized by too many T-cell lymphoblasts found in the bone marrow and blood. http://purl.obolibrary.org/obo/DOID_5621 histiocytic and dendritic cell cancer http://purl.obolibrary.org/obo/DOID_2531 hematologic cancer A sarcoma and hematologic cancer that derives_from follicular lymphoma. http://purl.obolibrary.org/obo/DOID_5636 cervical adenosquamous carcinoma http://purl.obolibrary.org/obo/DOID_1749 squamous cell carcinoma A cervical carcinoma that derives_from squamous cells and gland-like cells. http://purl.obolibrary.org/obo/DOID_5648 choroid plexus carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A choroid plexus cancer that has_material_basis_in epithelial cells of the choroid plexus. http://purl.obolibrary.org/obo/DOID_5658 lipid-rich carcinoma http://purl.obolibrary.org/obo/DOID_3459 breast carcinoma A breast carcinoma characterized by the presence of malignant epithelial cells with clear cytoplasm which contains neutral lipids. http://purl.obolibrary.org/obo/DOID_5665 external ear cancer http://purl.obolibrary.org/obo/DOID_5101 ear cancer An ear cancer that is located_in the external ear. http://purl.obolibrary.org/obo/DOID_5675 cribriform carcinoma http://purl.obolibrary.org/obo/DOID_3459 breast carcinoma A breast carcinoma that is characterized by an irregular cribriform growth pattern, nuclear grade I in at least 90% of cells, and absent myoepithelial cells. http://purl.obolibrary.org/obo/DOID_5683 hereditary breast ovarian cancer syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by the higher than normal tendency associated with BRCA1 and BRCA2 to develop breast and ovarian cancers in genetically related families. http://purl.obolibrary.org/obo/DOID_5684 spondyloepimetaphyseal dysplasia, Sponastrime type http://purl.obolibrary.org/obo/DOID_0080027 spondyloepimetaphyseal dysplasia A spondyloepimetaphyseal dysplasia that is characterized by spondylar and nasal changes, with striations of the metaphyses that has_material_basis_in autosomal recessive inheritance. http://purl.obolibrary.org/obo/DOID_5688 Werner syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by premature aging and age-related phenotypes such as atherosclerosis, arteriosclerosis, cataracts, osteoporosis, soft tissue calcification, premature thinning, graying, and loss of hair, as well as a high incidence of some types of cancers and that has_material_basis_in mutations in the WRN gene, on chromosome 8. http://purl.obolibrary.org/obo/DOID_57 aortic valve insufficiency http://purl.obolibrary.org/obo/DOID_62 aortic valve disease An aortic valve disease that is characterized by leaking of the aortic valve of the heart causes blood to flow in the reverse direction during ventricular diastole, from the aorta into the left ventricle. http://purl.obolibrary.org/obo/DOID_5718 adrenal neuroblastoma http://purl.obolibrary.org/obo/DOID_3953 adrenal gland cancer An adrenal gland cancer that derives_from immature neuroblastic cells. http://purl.obolibrary.org/obo/DOID_5742 pancreatic acinar cell adenocarcinoma http://purl.obolibrary.org/obo/DOID_4074 pancreatic adenocarcinoma A pancreatic adenocarcinoma that has_material_basis_in cells with morphological resemblance to acinar cells and is associated with increased serum lipase. http://purl.obolibrary.org/obo/DOID_5746 ovarian serous cystadenocarcinoma http://purl.obolibrary.org/obo/DOID_3605 ovarian cystadenocarcinoma An ovary serous adenocarcinoma that has_material_basis_in glandular epithelium, in which cystic accumulations of retained secretions are formed. http://purl.obolibrary.org/obo/DOID_5757 endocervicitis http://purl.obolibrary.org/obo/DOID_2568 cervicitis A cervicitis that is located_in the endocervix. http://purl.obolibrary.org/obo/DOID_576 proteinuria http://purl.obolibrary.org/obo/DOID_557 kidney disease A kidney disease that is characterized by the presence of excess proteins in the urine. http://purl.obolibrary.org/obo/DOID_5773 oral submucous fibrosis http://purl.obolibrary.org/obo/DOID_403 mouth disease A mouth disease that is characterized by juxta-epithelial inflammatory reaction and progressive fibrosis of the submucosal tissues. http://purl.obolibrary.org/obo/DOID_580 uric acid nephrolithiasis http://purl.obolibrary.org/obo/DOID_585 nephrolithiasis A nephrolithiasis that is characterized by stones composed predominantly uric acid. http://purl.obolibrary.org/obo/DOID_5805 subvalvular aortic stenosis http://purl.obolibrary.org/obo/DOID_1712 aortic valve stenosis An aortic valve stenosis that is characterized by a narrowing of the section of the heart under the aortic valve resulting in left ventricular outflow obstruction. http://purl.obolibrary.org/obo/DOID_5813 purine nucleoside phosphorylase deficiency http://purl.obolibrary.org/obo/DOID_628 combined T cell and B cell immunodeficiency A combined T cell and B cell immunodeficiency that is a rare autosomal recessive metabolic disorder that has_material_basis_in mutation in the PNP gene and characterized mainly by decreased T-cell function. http://purl.obolibrary.org/obo/DOID_5820 composite lymphoma http://purl.obolibrary.org/obo/DOID_707 B-cell lymphoma A lymphoma that begins in cells of the immune system in which different types of lymphoma cells occur at the same time. http://purl.obolibrary.org/obo/DOID_5822 gray zone lymphoma http://purl.obolibrary.org/obo/DOID_0060058 lymphoma A lymphoma that is characterized by having cellular features of both classic Hodgkin's lymphomas and large B-cell Lymphomas. http://purl.obolibrary.org/obo/DOID_5826 breast lymphoma http://purl.obolibrary.org/obo/DOID_1612 breast cancer A breast cancer that arises_from lymphocytes. http://purl.obolibrary.org/obo/DOID_5828 endometrioid ovary carcinoma http://purl.obolibrary.org/obo/DOID_3713 ovary adenocarcinoma An ovary adenocarcinoma that has_material_basis_in endometrial tissue. http://purl.obolibrary.org/obo/DOID_5844 myocardial infarction http://purl.obolibrary.org/obo/DOID_3393 coronary artery disease A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia. http://purl.obolibrary.org/obo/DOID_585 nephrolithiasis http://purl.obolibrary.org/obo/DOID_557 kidney disease A kidney disease characterized by the formation of stoney concentrations in the kidneys. http://purl.obolibrary.org/obo/DOID_5870 eosinophilic pneumonia http://purl.obolibrary.org/obo/DOID_552 pneumonia A pneumonia in which certain type of white blood cell called an eosinophil accumulates in the lung. These cells cause disruption of the normal air spaces (alveoli) where oxygen is extracted from the atmosphere. It is caused by certain medications or environmental triggers, parasitic infections, and cancer. The most common symptoms include cough, fever, difficulty breathing, and sweating at night. http://purl.obolibrary.org/obo/DOID_593 agoraphobia http://purl.obolibrary.org/obo/DOID_591 phobic disorder A phobic disorder involving the specific anxiety about being in a place or situation where escape is difficult or embarrassing or where help may be unavailable. http://purl.obolibrary.org/obo/DOID_594 panic disorder http://purl.obolibrary.org/obo/DOID_2030 anxiety disorder An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress. http://purl.obolibrary.org/obo/DOID_6067 ovarian mucinous neoplasm http://purl.obolibrary.org/obo/DOID_2152 ovary epithelial cancer An ovary epithelial cancer that is characterized by the presence of mucin. http://purl.obolibrary.org/obo/DOID_6088 acute stress disorder http://purl.obolibrary.org/obo/DOID_2030 anxiety disorder An anxiety disorder that has_symptom flashbacks, has_symptom bad dreams, has_symptom frightening thoughts, has_symptom avoidance or has_symptom hyperarousal of PTSD occurring within one month of a traumatic experience as Acute Stress Disorder or ASD. http://purl.obolibrary.org/obo/DOID_6126 anal canal carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma An anal canal cancer that derives_from epithelial cells. http://purl.obolibrary.org/obo/DOID_6132 bronchitis http://purl.obolibrary.org/obo/DOID_1176 bronchial disease A bronchial disease that is an inflammation of the bronchial tubes. It is caused by bacteria and viruses. The disease has_symptom cough with mucus, has_symptom shortness of breath, has_symptom low fever and has_symptom chest tightness. http://purl.obolibrary.org/obo/DOID_614 lymphopenia http://purl.obolibrary.org/obo/DOID_615 leukopenia A leukopenia that is the condition of having an abnormally low level of lymphocytes in the blood. http://purl.obolibrary.org/obo/DOID_6179 ovarian small cell carcinoma http://purl.obolibrary.org/obo/DOID_4001 ovarian carcinoma An ovarian carcinoma that is an undifferentiated neoplasm composed of primitive-appearing cells. http://purl.obolibrary.org/obo/DOID_6193 epithelioid sarcoma http://purl.obolibrary.org/obo/DOID_201 connective tissue cancer A connective tissue cancer that is characterized by the presence of epithelioid cells forming nodular patterns and has_material_basis_in mesenchymal tissue. http://purl.obolibrary.org/obo/DOID_6196 reactive arthritis http://purl.obolibrary.org/obo/DOID_848 arthritis An arthritis that is an autoimmune disease which develops due to an infection located elsewhere in the body. http://purl.obolibrary.org/obo/DOID_6217 gastric diffuse adenocarcinoma http://purl.obolibrary.org/obo/DOID_3717 gastric adenocarcinoma A gastric adenocarcinoma that is characterized by the presence of a diffuse infiltrate, composed of individual adenocarcinoma cells or groups of adenocarcinoma cells in a fibrous or mucoid stroma. http://purl.obolibrary.org/obo/DOID_6262 follicular dendritic cell sarcoma http://purl.obolibrary.org/obo/DOID_7849 dendritic cell sarcoma A dendritic cell sarcoma cancer that effects the follicular dendritic cells. http://purl.obolibrary.org/obo/DOID_6263 inflammatory breast carcinoma http://purl.obolibrary.org/obo/DOID_3458 breast adenocarcinoma A breast adenocarcinoma that is characterized by the clinical appearance of inflammation, with edema and redness of the breast due to pathologic plugging of the dermal lymphatics of the breast with tumor emboli. http://purl.obolibrary.org/obo/DOID_635 acquired immunodeficiency syndrome http://purl.obolibrary.org/obo/DOID_526 human immunodeficiency virus infectious disease A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per microliter of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS. http://purl.obolibrary.org/obo/DOID_6354 CLL/SLL http://purl.obolibrary.org/obo/DOID_1040 chronic lymphocytic leukemia A chronic lymphocytic leukemia that is characterized by the presence of immature lymphocytes in the blood and bone marrow and/or in the lymph nodes. http://purl.obolibrary.org/obo/DOID_636 central pontine myelinolysis http://purl.obolibrary.org/obo/DOID_3213 demyelinating disease A demyelination disease that is characterized by severe damage to the myelin sheath of the pons' nerve cells and has_symptom acute paralysis, has_symptom dysphagia, and has_symptom dysarthria. http://purl.obolibrary.org/obo/DOID_6367 acral lentiginous melanoma http://purl.obolibrary.org/obo/DOID_8923 skin melanoma A skin melanoma that is characterized by slow growth of a small pigmented spot on the skin with a clearly defined edge, surrounded by normal-appearing skin and occurs on occurs on non hair-bairing surfaces including hands and feet, subungual sites, and fingers or toes. http://purl.obolibrary.org/obo/DOID_643 progressive multifocal leukoencephalopathy http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that involves reactivation of JC polyomavirus in immune-compromised individuals which causes the loss of white matter (which is made up of myelin, a substance the surrounds and protects nerve fibers) in multiple areas of the brain. The symptoms include hemiparesis, aphasia, dysarthria, hemianopia, cognitive impairment and coma. http://purl.obolibrary.org/obo/DOID_6457 Cowden syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by multiple noncancerous, tumor-like growths (hamartomas) and an increased risk of certain forms of cancer, especially breast, thyroid and endometrium. http://purl.obolibrary.org/obo/DOID_6469 ovarian mucinous adenofibroma http://purl.obolibrary.org/obo/DOID_0060112 ovarian benign neoplasm An ovarian benign neoplasm that is characterized by low beta-hCG levels and is has_material_basis_in glandular and fibrous tissues, with a relatively large proportion of glands. http://purl.obolibrary.org/obo/DOID_6496 extraskeletal myxoid chondrosarcoma http://purl.obolibrary.org/obo/DOID_4549 extraosseous chondrosarcoma An extraosseous chondrosarcoma that has_material_basis_in cells derived from transformed cells that produce cartilage and is characterized by a marked abundance of extracellular mucoid (myxoid) matrix. http://purl.obolibrary.org/obo/DOID_6536 plasma cell neoplasm http://purl.obolibrary.org/obo/DOID_706 mature B-cell neoplasm A mature B-cell neoplasm that is composed of plasma cells. http://purl.obolibrary.org/obo/DOID_6543 acne http://purl.obolibrary.org/obo/DOID_9098 sebaceous gland disease A sebaceous gland disease characterized by areas of blackheads, whiteheads, pimples, greasy skin, and possibly scarring. http://purl.obolibrary.org/obo/DOID_6612 leukocyte adhesion deficiency http://purl.obolibrary.org/obo/DOID_9500 leukocyte disease A combined T cell and B cell immunodeficiency that is characterized by defects affecting how white blood cells respond and travel to the site of a wound or infection affecting the immune system. http://purl.obolibrary.org/obo/DOID_6620 X-linked hyper IgM syndrome http://purl.obolibrary.org/obo/DOID_0080544 hyper IgM syndrome A hyper IgM syndrome that is characterized by neutropenia and a high rate of gastrointestinal and central nervous system infections and that has_material_basis_in a mutation in the CD40LG gene (300386) on chromosome Xq26. http://purl.obolibrary.org/obo/DOID_6621 cerebral angioma http://purl.obolibrary.org/obo/DOID_5393 brain angioma A brain angioma that is characterized by vascular abnormalities that develops from cranial and spinal blood vasculature, has_material_basis_in abnormally proliferating cells, derives_from endothelial cells in and about the vascular lumen. http://purl.obolibrary.org/obo/DOID_6652 diffuse idiopathic skeletal hyperostosis http://purl.obolibrary.org/obo/DOID_182 calcinosis A calcinosis that is the calcification or a bony hardening of ligaments in areas where they attach to your spine. http://purl.obolibrary.org/obo/DOID_6678 tooth and nail syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that affects the teeth, nails, hair, and/or skin. It is characterized by absence (hypodontia) and/or malformation of certain primary (deciduous) and secondary (permanent) teeth occurring in association with improper development of the nails, particularly the toenails. http://purl.obolibrary.org/obo/DOID_668 myositis ossificans http://purl.obolibrary.org/obo/DOID_633 myositis A myositis that is accompanied by ossification of muscle tissue or bony deposits in the muscles. http://purl.obolibrary.org/obo/DOID_6680 Capgras syndrome http://purl.obolibrary.org/obo/DOID_778 delusional disorder A delusional disorder in which a person holds a delusion that a friend, spouse, parent, or other close family member has been replaced by an identical-looking impostor. http://purl.obolibrary.org/obo/DOID_6682 spondylolisthesis http://purl.obolibrary.org/obo/DOID_0080010 bone structure disease A bone structure disease that has_material_basis_in displacement located_in set of vertebrae. http://purl.obolibrary.org/obo/DOID_6683 X-linked Aarskog syndrome http://purl.obolibrary.org/obo/DOID_0111824 Aarskog syndrome A syndromic X-linked intellectual disability affects a person's height, muscles, skeleton, genitals, and appearance of the face. http://purl.obolibrary.org/obo/DOID_6712 anterior spinal artery syndrome http://purl.obolibrary.org/obo/DOID_6713 cerebrovascular disease A syndrome that is characterized by loss of function of the anterior two-thirds of the spinal cord that results from ischemia of the anterior spinal artery. http://purl.obolibrary.org/obo/DOID_6725 spinal stenosis http://purl.obolibrary.org/obo/DOID_0080007 bone deterioration disease A bone deterioration disease that has_material_basis_in bony spurs, disc degeneration, or thickened ligaments which results_in narrowing located_in spinal cord. http://purl.obolibrary.org/obo/DOID_676 juvenile rheumatoid arthritis http://purl.obolibrary.org/obo/DOID_7148 rheumatoid arthritis A rheumatoid arthritis that involves an autoimmune disease onset in children under 16 which attacks the healthy cells and tissue of located_in joint. http://purl.obolibrary.org/obo/DOID_678 progressive supranuclear palsy http://purl.obolibrary.org/obo/DOID_480 movement disease A movement disease that is characterized by serious and progressive problems with control of gait and balance, along with complex eye movement and thinking problems. It involves gradual deterioration and death of specific volumes of the brain. http://purl.obolibrary.org/obo/DOID_6811 juvenile pilocytic astrocytoma http://purl.obolibrary.org/obo/DOID_4851 pilocytic astrocytoma A pilocytic astrocytoma that occurs during adolescence. http://purl.obolibrary.org/obo/DOID_684 hepatocellular carcinoma http://purl.obolibrary.org/obo/DOID_686 liver carcinoma A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver. http://purl.obolibrary.org/obo/DOID_686 liver carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A liver cancer that has_material_basis_in epithelial cells. http://purl.obolibrary.org/obo/DOID_688 embryonal cancer http://purl.obolibrary.org/obo/DOID_2994 germ cell cancer A germ cell cancer that is associated with an embryo. http://purl.obolibrary.org/obo/DOID_6903 eye lymphoma http://purl.obolibrary.org/obo/DOID_0060058 lymphoma A lymphoma by site that is manifested in immune system cells called lymphocytes. http://purl.obolibrary.org/obo/DOID_7004 ACTH-secreting pituitary adenoma http://purl.obolibrary.org/obo/DOID_5395 functioning pituitary adenoma A functioning pituitary adenoma that characterized by excess cortisol a primary cause of Cushing's syndrome. http://purl.obolibrary.org/obo/DOID_701 dentin dysplasia http://purl.obolibrary.org/obo/DOID_214 teeth hard tissue disease A teeth hard tissue disease characterized by presence of normal enamel but atypical dentin with abnormal pulpal morphology. http://purl.obolibrary.org/obo/DOID_7033 anisakiasis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that results_in infection located_in intestinal mucosa with larvae of the nematodes transmitted_by ingestion of raw or poorly cooked saltwater fish, has_material_basis_in Anisakis simplex or has_material_basis_in Pseudoterranova decipiens and has_symptom abdominal pain, has_symptom nausea and vomiting. Invasive anisakiasis results in the infection of omentum, pancreas, liver, and lung. http://purl.obolibrary.org/obo/DOID_7146 Langerhans cell sarcoma http://purl.obolibrary.org/obo/DOID_9500 leukocyte disease A histiocytic and dendritic cell cancer that derives from the lymph nodes, derives from the skin, derives from the liver, derives from the spleen and derives from bones. http://purl.obolibrary.org/obo/DOID_7147 ankylosing spondylitis http://purl.obolibrary.org/obo/DOID_3342 bone inflammation disease A bone inflammation disease that results_in inflammation in the joints of the spine and pelvis. The disease has_symptom pain, has_symptom stiffness in the spine, has_symptom stiffness in the neck, has_symptom stiffness in the hips, has_symptom stiffness in the jaw and has_symptom stiffness in the rib cage. http://purl.obolibrary.org/obo/DOID_7148 rheumatoid arthritis http://purl.obolibrary.org/obo/DOID_848 arthritis An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint. http://purl.obolibrary.org/obo/DOID_718 autoimmune hemolytic anemia http://purl.obolibrary.org/obo/DOID_0060050 autoimmune disease of blood An autoimmune disease of blood that is characterized by deficient red blood cells caused by auto-antibodies. http://purl.obolibrary.org/obo/DOID_7188 autoimmune thyroiditis http://purl.obolibrary.org/obo/DOID_0060005 autoimmune disease of endocrine system An autoimmune disease of endocrine system that involves inflammation located_in thyroid gland caused by the immune system reacting against its own tissues. http://purl.obolibrary.org/obo/DOID_7223 breast giant fibroadenoma http://purl.obolibrary.org/obo/DOID_1618 breast fibroadenoma A breast fibroadenoma that is larger than 5 cm. http://purl.obolibrary.org/obo/DOID_734 urethra cancer http://purl.obolibrary.org/obo/DOID_732 urethral disease An urinary tract cancer that derives_from the tissues of the urethra. http://purl.obolibrary.org/obo/DOID_7400 Nijmegen breakage syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by chromosomal instability, microcephaly, growth retardation, immunodeficiency, cellular hypersensitivity to X-rays, and predisposition to cancer that has_material_basis_in homozygous or compound heterozygous mutation in NBN on chromosome 8q21.3. http://purl.obolibrary.org/obo/DOID_7426 cutaneous anthrax http://purl.obolibrary.org/obo/DOID_7427 anthrax disease An anthrax disease that results_in infection located_in skin, has_material_basis_in Bacillus anthracis, which is transmitted_by contact with infected animals or animal products. The infection has_symptom skin lesion that eventually forms an ulcer with a black center. http://purl.obolibrary.org/obo/DOID_7442 monoclonal gammopathy of uncertain significance http://purl.obolibrary.org/obo/DOID_620 blood protein disease A blood protein disease that is characterized by the presence of an abnormal protein called monoclonal protein in the blood. http://purl.obolibrary.org/obo/DOID_7457 enterobiasis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that involves infection of the anus by the pinworm Enterobius vermicularis. The major symptom is perianal itching. Infected people experience perianal pruritus and excoriations from scratching. http://purl.obolibrary.org/obo/DOID_7465 chronic NK-cell lymphocytosis http://purl.obolibrary.org/obo/DOID_2916 hypersensitivity reaction type IV disease A hypersensitivity reaction type IV disease that is characterized by absolute lymphocytosis of natural killer (CD3- CD16+) cells often with concurrent cytopenia and has_symptom fever, arthralgia, apthous ulcers, vasculitic skin rash, and peripheral neuropathy. http://purl.obolibrary.org/obo/DOID_7474 malignant pleural mesothelioma http://purl.obolibrary.org/obo/DOID_5158 pleural cancer A pleural cancer that has_material_basis_in mesothelium cells. http://purl.obolibrary.org/obo/DOID_7489 Osgood-Schlatter's disease http://purl.obolibrary.org/obo/DOID_3342 bone inflammation disease A bone inflammation disease that involves rupture of the growth plate in children located_in tibia. http://purl.obolibrary.org/obo/DOID_7608 parathyroid adenoma http://purl.obolibrary.org/obo/DOID_60008 parathyroid gland benign neoplasm A parathyroid gland benign neoplam that is located_in the parathyroid. http://purl.obolibrary.org/obo/DOID_7615 sarcomatosis http://purl.obolibrary.org/obo/DOID_1115 sarcoma A sarcoma that results_in the formation of numerous sarcomas or located_in various parts of the body. http://purl.obolibrary.org/obo/DOID_768 retinoblastoma http://purl.obolibrary.org/obo/DOID_771 retinal cell cancer A retinal cell cancer and malignant neoplasm of retina and neuroblastoma and neuroendocrine tumors that derives_from the tissues of the retina. http://purl.obolibrary.org/obo/DOID_7693 abdominal aortic aneurysm http://purl.obolibrary.org/obo/DOID_3627 aortic aneurysm An aortic aneurysm that is located_in the abdominal aorta. http://purl.obolibrary.org/obo/DOID_771 retinal cell cancer http://purl.obolibrary.org/obo/DOID_4645 retinal cancer A malignant neoplasm that derives_from the retina. http://purl.obolibrary.org/obo/DOID_7725 epilepsy with generalized tonic-clonic seizures http://purl.obolibrary.org/obo/DOID_0050705 adolescence-adult electroclinical syndrome An adolescence-adult electroclinical syndrome starting in adolescence exhibiting generalized tonic-clonic seizures as the only seizure type. http://purl.obolibrary.org/obo/DOID_778 delusional disorder http://purl.obolibrary.org/obo/DOID_2468 psychotic disorder A psychotic disorder that involves an uncommon psychiatric condition in which patients present with circumscribed symptoms of non-bizarre delusions, but with the absence of prominent hallucinations and no thought disorder, mood disorder, or significant flattening effect. http://purl.obolibrary.org/obo/DOID_783 end stage renal disease http://purl.obolibrary.org/obo/DOID_784 chronic kidney disease A chronic kidney disease is characterized by non-functioning kidneys, as the final stage in chronic kidney disease. http://purl.obolibrary.org/obo/DOID_784 chronic kidney disease http://purl.obolibrary.org/obo/DOID_1074 kidney failure A kidney failure that is characterized by the gradual loss of kidney function. http://purl.obolibrary.org/obo/DOID_7843 female breast carcinoma http://purl.obolibrary.org/obo/DOID_3459 breast carcinoma A breast carcinoma that is manifested in the female breast. http://purl.obolibrary.org/obo/DOID_7849 dendritic cell sarcoma http://purl.obolibrary.org/obo/DOID_1115 sarcoma A histiocytic and dendritic cell cancer that is mainly located_in lymph nodes. http://purl.obolibrary.org/obo/DOID_7880 luteoma http://purl.obolibrary.org/obo/DOID_0060112 ovarian benign neoplasm An ovarian benign neoplasm characterized by solid proliferations of luteinized cells, resulting in a tumor-like ovarian enlargement that regresses during the puerperium. http://purl.obolibrary.org/obo/DOID_7894 mite infestation http://purl.obolibrary.org/obo/DOID_4110 parasitic ectoparasitic infectious disease A parasitic ectoparasitic infectious disease that involves infestation of mites belonging to the family Sarcoptidae, Trombiculidae and Demodicidae. http://purl.obolibrary.org/obo/DOID_799 varicose veins http://purl.obolibrary.org/obo/DOID_866 vein disease A vein disease that is characterized by swollen, twisted veins visible just under the surface of the skin. http://purl.obolibrary.org/obo/DOID_8029 sporadic breast cancer http://purl.obolibrary.org/obo/DOID_3459 breast carcinoma A breast carcinoma that occurs in people who do not have a family history of that cancer or an inherited change in their DNA that would increase their risk for that cancer. http://purl.obolibrary.org/obo/DOID_809 cocaine abuse http://purl.obolibrary.org/obo/DOID_302 substance abuse A substance abuse that involves the recurring use of cocaine despite negative consequences. http://purl.obolibrary.org/obo/DOID_813 septic arthritis http://purl.obolibrary.org/obo/DOID_848 arthritis An arthritis that involves infection by a pathogen located_in joint. http://purl.obolibrary.org/obo/DOID_819 mediastinitis http://purl.obolibrary.org/obo/DOID_65 connective tissue disease A connective tissue disease characterized by inflammation located_in the mediastinum, which extends from the diaphragm to the thoracic inlet and between the pleural cavities. http://purl.obolibrary.org/obo/DOID_820 myocarditis http://purl.obolibrary.org/obo/DOID_3978 extrinsic cardiomyopathy An extrinsic cardiomyopathy that is characterized as an inflammation of the heart muscle. http://purl.obolibrary.org/obo/DOID_8302 mixed endometrial stromal and smooth muscle tumor http://purl.obolibrary.org/obo/DOID_9460 uterine corpus cancer A uterine corpus cancer that has_material_basis_in endometrial stroma and smooth muscle cells. http://purl.obolibrary.org/obo/DOID_833 auditory system cancer http://purl.obolibrary.org/obo/DOID_2742 auditory system disease An organ system cancer located_in the ear and characterized by uncontrolled cellular proliferation of the auditory organs. http://purl.obolibrary.org/obo/DOID_8337 appendicitis http://purl.obolibrary.org/obo/DOID_1518 cecal disease A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has_symptom pain, in the upper abdomen initially and later in the lower abdomen, has_symptom nausea, has_symptom vomiting and has_symptom fever. http://purl.obolibrary.org/obo/DOID_8354 complement component 3 deficiency http://purl.obolibrary.org/obo/DOID_626 complement deficiency A complement deficiency that is characterized by deficiency of complement component 3 that increases susceptibility to infection and autoimmune diseases and has_material_basis_in autosomal recessive inheritance of mutation in the C3 gene on chromosome 19p13.3, has_symptom recurrent bacterial infections. http://purl.obolibrary.org/obo/DOID_8398 osteoarthritis http://purl.obolibrary.org/obo/DOID_848 arthritis An arthritis that has_material_basis_in worn out cartilage located_in joint. http://purl.obolibrary.org/obo/DOID_84 osteochondritis dissecans http://purl.obolibrary.org/obo/DOID_0080008 ischemic bone disease An ischemic bone disease that results_in necrosis located_in epiphysis. http://purl.obolibrary.org/obo/DOID_8438 afferent loop syndrome http://purl.obolibrary.org/obo/DOID_8439 postgastrectomy syndrome A postgastrectomy syndrome that is characterized by obstruction of the afferent loop that arises after gastric surgery with gastrojejunostomy reconstruction. http://purl.obolibrary.org/obo/DOID_8443 brachial plexus lesion http://purl.obolibrary.org/obo/DOID_3690 brachial plexus neuropathy A brachial plexus neuropathy characterized by an abnormality, usually caused by disease or trauma, located in the brachial plexus. http://purl.obolibrary.org/obo/DOID_8445 intestinal volvulus http://purl.obolibrary.org/obo/DOID_8437 intestinal obstruction An intestinal obstruction characterized by abnormal rotation of the intestines. http://purl.obolibrary.org/obo/DOID_845 cyclothymic disorder http://purl.obolibrary.org/obo/DOID_3312 bipolar disorder A bipolar disorder that involves recurrent hypomanic and dysthymic episodes, but no full manic episodes or full major depressive episodes. http://purl.obolibrary.org/obo/DOID_8454 riboflavin deficiency http://purl.obolibrary.org/obo/DOID_5113 nutritional deficiency disease A nutritional deficiency disease that is characterized by stomatitis, cheilosis, glossitis, conjunctivitis, and anemia, develops_from vitamin B2 (riboflavin) deficiency, has_symptom red chapped lips, painful swollen tongue, sore throat, blurred vision, and fatigue, and has_material_basis_in inadequate intake, endocrine disorder, liver disorder, alcoholism, and dialysis. http://purl.obolibrary.org/obo/DOID_8457 pellagra http://purl.obolibrary.org/obo/DOID_5113 nutritional deficiency disease A nutritional deficiency disease that is characterized by deficiency of niacin (vitamin B3), has_symptom gastrointestinal disturbance, anorexia, diarrhea, dementia, hallucinations, depression, psychosis, and/or non-specific skin changes, and has_material_basis_in deficiency of niacin, often from inadequate diet, malabsorption, or medication side effects. http://purl.obolibrary.org/obo/DOID_8461 Aicardi syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by absence or underdeveloped tissue connecting the left and right halves of the brain, infantile spasms and chorioretinal lacunae, which are defects in the light-sensitive tissue at the back of the eye. http://purl.obolibrary.org/obo/DOID_8478 actinomycosis http://purl.obolibrary.org/obo/DOID_1579 respiratory system disease A commensal bacterial infectious disease that results in infection, which is characterized by contiguous spread, suppurative and granulomatous inflammation, and formation of multiple abscesses and sinus tracts that may discharge sulfur granules, has_material_basis_in Actinomyces israelii, has_material_basis_in Actinomyces gerencseriae, has_material_basis_in Actinomyces naeslundii, has_material_basis_in Actinomyces odontolyticus, has_material_basis_in Actinomyces viscosus, has_material_basis_in Actinomyces meyeri, has_material_basis_in Propionibacterium propionicum, which require a break in the integrity of the mucous membranes and the presence of devitalized tissue to invade deeper body structures. http://purl.obolibrary.org/obo/DOID_8488 polyhydramnios http://purl.obolibrary.org/obo/DOID_780 placenta disease A placenta disease that is characterized by an excess of amniotic fluid in the amniotic sac. http://purl.obolibrary.org/obo/DOID_8506 bullous pemphigoid http://purl.obolibrary.org/obo/DOID_0060039 autoimmune disease of skin and connective tissue An autoimmune disease of skin and connective tissue characterized by large blisters. http://purl.obolibrary.org/obo/DOID_8527 monocytic leukemia http://purl.obolibrary.org/obo/DOID_8692 myeloid leukemia A myeloid leukemia that is characterized by a dominance of monocytes in the marrow. http://purl.obolibrary.org/obo/DOID_8533 hypopharynx cancer http://purl.obolibrary.org/obo/DOID_0060119 pharynx cancer A pharynx cancer that is located_in the hypopharynx. http://purl.obolibrary.org/obo/DOID_8536 herpes zoster http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in infection located_in nerve fiber, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The virus is transmitted_by direct contact with the rash, which can develop into chickenpox in newly-infected individuals. The infection has_symptom rash which is followed by blisters, has_symptom headache, has_symptom fever, has_symptom malaise, has_symptom itching, has_symptom burning pain, and has_symptom paresthesia. http://purl.obolibrary.org/obo/DOID_8544 chronic fatigue syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that involves prolonged and severe tiredness or weariness that is unrelated to exertion, is not relieved by rest and for a minimum of six months and is not directly caused by other conditions. http://purl.obolibrary.org/obo/DOID_8545 malignant hyperthermia http://purl.obolibrary.org/obo/DOID_66 muscle tissue disease A muscle tissue disease that is characterized by a drastic and uncontrolled increase in skeletal muscle oxidative metabolism, which overwhelms the body's capacity to supply oxygen, remove carbon dioxide, and regulate body temperature. http://purl.obolibrary.org/obo/DOID_8557 oropharynx cancer http://purl.obolibrary.org/obo/DOID_0060119 pharynx cancer A pharynx cancer that is located_in the oropharynx. http://purl.obolibrary.org/obo/DOID_856 biotinidase deficiency http://purl.obolibrary.org/obo/DOID_857 multiple carboxylase deficiency A multiple carboxylase deficiency that involves a deficiency in biotinidase. http://purl.obolibrary.org/obo/DOID_8566 herpes simplex http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in_formation_of lesions, located_in mouth, located_in face, located_in genitalia, or located_in hands, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which are transmitted_by direct contact with an active lesion or body fluid of an infected person. http://purl.obolibrary.org/obo/DOID_8567 Hodgkin's lymphoma http://purl.obolibrary.org/obo/DOID_0060058 lymphoma A lymphoma that is marked by the presence of a type of cell called the Reed-Sternberg cell. http://purl.obolibrary.org/obo/DOID_8568 infectious mononucleosis http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results in inflammation, located in pharynx, has_material_basis_in Human herpesvirus 4 and has symptom fever, has symptom fatigue, has symptom lymphadenopathy, and has symptom splenomegaly. http://purl.obolibrary.org/obo/DOID_857 multiple carboxylase deficiency http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder An amino acid metabolic disorder that involves failures of carboxylation enzymes. http://purl.obolibrary.org/obo/DOID_8577 ulcerative colitis http://purl.obolibrary.org/obo/DOID_0060180 colitis A colitis that is predominantly confined to the mucosa located_in colon and includes characteristic ulcers, or open sores. http://purl.obolibrary.org/obo/DOID_8584 Burkitt lymphoma http://purl.obolibrary.org/obo/DOID_706 mature B-cell neoplasm A mature B-cell neoplasm of B-cells found in the germinal center. http://purl.obolibrary.org/obo/DOID_859 holocarboxylase synthetase deficiency http://purl.obolibrary.org/obo/DOID_857 multiple carboxylase deficiency A multiple carboxylase deficiency that involves a deficiency in holocarboxylase synthetase. http://purl.obolibrary.org/obo/DOID_8596 scarlet fever http://purl.obolibrary.org/obo/DOID_974 upper respiratory tract disease An upper respiratory tract disease described as an acute contagious disease caused by Group A bacteria of the genus Streptococcus (especially various strains of S. pyogenes) and characterized by inflammation of the nose, throat, and mouth, generalized toxemia, and a red rash. http://purl.obolibrary.org/obo/DOID_8622 measles http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in infection located_in skin, has_material_basis_in Measles virus, which is transmitted_by contact with oronasal secretions, or semen of an infected person. The infection has_symptom fever, has_symptom cough, has_symptom coryza, has_symptom conjunctivitis, and has_symptom maculopapular, erythematous rash. http://purl.obolibrary.org/obo/DOID_8632 Kaposi's sarcoma http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A connective tissue cancer that derives_from lymphatic endothelium, and derives_from spindle cells, results_in_formation_of vascular channels that fill with blood cells, has_material_basis_in Human herpesvirus 8 (HHV8). http://purl.obolibrary.org/obo/DOID_8634 prostate carcinoma in situ http://purl.obolibrary.org/obo/DOID_8719 in situ carcinoma An in situ carcinoma that is located_in the prostate. http://purl.obolibrary.org/obo/DOID_8659 chickenpox http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human herpesvirus 3, which is transmitted_by direct contact with secretions from the rash, or transmitted_by droplet spread of respiratory secretions. The infection has_symptom anorexia, has_symptom myalgia, has_symptom nausea, has_symptom fever, has_symptom headache, has_symptom sore throat, and has_symptom blisters. http://purl.obolibrary.org/obo/DOID_8687 skin carcinoma in situ http://purl.obolibrary.org/obo/DOID_8719 in situ carcinoma A carcinoma in situ that is characterized by the spread of cancer in skin and the lack of invasion of surrounding tissues. http://purl.obolibrary.org/obo/DOID_8692 myeloid leukemia http://purl.obolibrary.org/obo/DOID_1240 leukemia A leukemia that is located_in myeloid tissue. http://purl.obolibrary.org/obo/DOID_8704 genital herpes http://purl.obolibrary.org/obo/DOID_8566 herpes simplex A herpes simplex that results_in infection located_in genital system, or located_in rectum, has_material_basis_in Human herpesvirus 1 or has_material_basis_in Human herpesvirus 2, which is transmitted_by sexual contact. The infection has_symptom sores, has_symptom fever, and has_symptom swollen glands. http://purl.obolibrary.org/obo/DOID_8717 decubitus ulcer http://purl.obolibrary.org/obo/DOID_8549 chronic ulcer of skin Decubitus ulcer is a chronic ulcer of skin where the ulcer is an ulceration of tissue deprived of adequate blood supply by prolonged pressure. http://purl.obolibrary.org/obo/DOID_8725 vascular dementia http://purl.obolibrary.org/obo/DOID_1307 dementia A dementia that involves impairments in cognitive function caused by problems in blood vessels that feed the brain. http://purl.obolibrary.org/obo/DOID_8741 seborrheic dermatitis http://purl.obolibrary.org/obo/DOID_2723 dermatitis A dermatitis that is an inflammatory skin condition resulting in flaky, white to yellowish scales on oily areas such as the scalp or inside the ear, which is caused due to a combination of an over production of skin oil and irritation from a yeast Malassezia furfur. The symptoms include itching, skin lesions and scales, redness, plaques and hair loss. http://purl.obolibrary.org/obo/DOID_8761 acute megakaryocytic leukemia http://purl.obolibrary.org/obo/DOID_9119 acute myeloid leukemia An acute myeloid leukemia that derives from blood-forming tissue in which megakaryocytes proliferate in the bone marrow and circulate in the blood in large numbers. http://purl.obolibrary.org/obo/DOID_8771 contagious pustular dermatitis http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in infection located_in skin, has_material_basis_in Orf virus, which is transmitted_by contact with infected or recently vaccinated animals, or transmitted_by fomites carrying the virus. The infection has_symptom lesions on the finger, hand, arm, face, and penis. http://purl.obolibrary.org/obo/DOID_8781 rubella http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in infection located_in skin, has_material_basis_in Rubella virus, which is transmitted_by droplet spread of oronasal secretions from the infected person through coughing and sneezing, and transmitted_by congenital method. The infection has_symptom rash on the face which spreads to the trunk and limbs, has_symptom fever, has_symptom lymphadenopathy, has_symptom joint pains, has_symptom headache, and has_symptom conjunctivitis. http://purl.obolibrary.org/obo/DOID_8800 lung carcinoma in situ http://purl.obolibrary.org/obo/DOID_8719 in situ carcinoma An in situ carcinoma that is located_in the lung. http://purl.obolibrary.org/obo/DOID_8826 colon carcinoma in situ http://purl.obolibrary.org/obo/DOID_5353 colonic disease An intestine carcinoma in situ that is located_in the colon. http://purl.obolibrary.org/obo/DOID_884 metagonimiasis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine by Metagonimus yokogawai. The symptoms are diarrhea and colicky abdominal pain. The heart and brain can also be infected. http://purl.obolibrary.org/obo/DOID_885 fascioliasis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Fasciola hepatica or Fasciola gigantica. During the acute phase, manifestations include abdominal pain, hepatomegaly, fever, vomiting, diarrhea, urticaria and eosinophilia. Occasionally, infection occurs in intestinal wall, lungs, subcutaneous tissue, and pharyngeal mucosa. http://purl.obolibrary.org/obo/DOID_8867 molluscum contagiosum http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in infection located_in skin, has_material_basis_in Molluscum contagiosum virus, which is transmitted_by contact with the skin, and transmitted_by fomites. The infection has_symptom lesions which are flesh-colored with a pit in the center. http://purl.obolibrary.org/obo/DOID_8869 neuromyelitis optica http://purl.obolibrary.org/obo/DOID_319 spinal cord disease A central nervous system disease characterized by inflammation of the optic nerve (optic neuritis) and inflammation of the spinal cord (myelitis). http://purl.obolibrary.org/obo/DOID_888 fasciolopsiasis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine by Fasciolopsis buski. The symptoms include diarrhea, abdominal pain, fever, ascites, anasarca and intestinal obstruction. http://purl.obolibrary.org/obo/DOID_8893 psoriasis http://purl.obolibrary.org/obo/DOID_0060039 autoimmune disease of skin and connective tissue A skin disease that is characterized by patches of thick red skin and silvery scales. http://purl.obolibrary.org/obo/DOID_891 progressive myoclonus epilepsy http://purl.obolibrary.org/obo/DOID_0050706 variable age at onset electroclinical syndrome A variable age at onset electroclinical syndrome characterised by a relentlessly progressive disease course until death. http://purl.obolibrary.org/obo/DOID_8912 tinea nigra http://purl.obolibrary.org/obo/DOID_0050133 superficial mycosis A superficial mycosis that is a superficial fungal infection of the skin characterized by brown to black macules which usually occur on the palmar aspects of hands and occasionally the plantar and other surfaces of the skin, caused by Hortaea werneckii, which is a common saprophytic fungus believed to occur in soil, compost, humus and on wood in humid tropical and sub-tropical regions. http://purl.obolibrary.org/obo/DOID_8924 autoimmune thrombocytopenic purpura http://purl.obolibrary.org/obo/DOID_8925 primary thrombocytopenia A primary thrombocytopenia that involves relatively few platelets in blood as a result of autoantibodies. http://purl.obolibrary.org/obo/DOID_8943 lattice corneal dystrophy http://purl.obolibrary.org/obo/DOID_0060441 epithelial-stromal TGFBI dystrophy An epithelial-stromal TGFBI dystrophy that is characterized by recurrent erosions and lattice line refractile and fleck-like opacification located_in the cornea, amyloid deposits beginning in the anterior stroma, and progressive vision loss later in life, and has_material_basis_in autosomal dominant inheritance of mutation of transforming growth factor beta-induced gene located in chromosome 5q31.1, which encodes keratoepithelin. Abnormalities lead to increased amyloid protein deposition and disruption of the corneal surface. http://purl.obolibrary.org/obo/DOID_8956 cowpox http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in infection in rodents, cows, and humans, located_in skin, has_material_basis_in Cowpox virus, which is transmitted_by contact with an infected animal. The infection results_in_formation_of vesicopustular lesions on the hands or face. http://purl.obolibrary.org/obo/DOID_8970 subacute sclerosing panencephalitis http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in infection located_in brain and that has_material_basis_in Measles virus which is immune resistant. http://purl.obolibrary.org/obo/DOID_8991 cervix uteri carcinoma in situ http://purl.obolibrary.org/obo/DOID_2253 cervix disease An uterus carcinoma in situ that is located_in the uterine cervix. http://purl.obolibrary.org/obo/DOID_8997 polycythemia vera http://purl.obolibrary.org/obo/DOID_2226 myeloproliferative neoplasm A myeloproliferative neoplasm characterized by erythroid hyperplasia, myeloid leukocytosis, thrombocytosis, and splenomegaly. http://purl.obolibrary.org/obo/DOID_90 degenerative disc disease http://purl.obolibrary.org/obo/DOID_0080007 bone deterioration disease A bone deterioration disease that has_material_basis_in gradual dehydration and tears located_in intervertebral disc. http://purl.obolibrary.org/obo/DOID_9007 sudden infant death syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by the sudden death of an infant that is not predicted by medical history and remains unexplained after a thorough forensic autopsy and detailed death scene investigation. http://purl.obolibrary.org/obo/DOID_9008 psoriatic arthritis http://purl.obolibrary.org/obo/DOID_848 arthritis An arthritis that is characterized by joint inflammation that usually occurs in combination with psoriasis. http://purl.obolibrary.org/obo/DOID_9024 intestine carcinoma in situ http://purl.obolibrary.org/obo/DOID_8719 in situ carcinoma An in situ carcinoma that is located_in the intestine. http://purl.obolibrary.org/obo/DOID_905 Zellweger syndrome http://purl.obolibrary.org/obo/DOID_0080377 peroxisomal biogenesis disorder A peroxisomal biogenesis disorder that is characterized by the reduction or absence of functional peroxisomes in the cells of an individual that has_material_basis_in autosomal recessive inheritance of a mutation in the peroxisome biogenesis factor (PEX) genes. http://purl.obolibrary.org/obo/DOID_9053 bladder carcinoma in situ http://purl.obolibrary.org/obo/DOID_8719 in situ carcinoma An in situ carcinoma that is located_in the bladder. http://purl.obolibrary.org/obo/DOID_9060 pityriasis versicolor http://purl.obolibrary.org/obo/DOID_0050133 superficial mycosis A superficial mycosis that is a chronic, superficial fungal infection of the skin caused by Malassezia furfur, which is characterized by well-demarcated white, pink, fawn, or brownish lesions, often coalescing, and covered with thin furfuraceous scales. http://purl.obolibrary.org/obo/DOID_9063 Ritter's disease http://purl.obolibrary.org/obo/DOID_37 skin disease A commensal bacterial infectious disease that is characterized by widespread erythema, peeling, and necrosis of the skin, that is caused by a toxin produced by a bacterium of the genus Staphylococcus (S. aureus). The infection has_symptoms redness of skin, has_symptom fluid-filled blister formation, has_symptom fever and has_symptom irritability. http://purl.obolibrary.org/obo/DOID_9065 leishmaniasis http://purl.obolibrary.org/obo/DOID_2789 parasitic protozoa infectious disease A parasitic protozoa infectious disease that involves infection caused by protozoan parasite of the genus Leishmania, which is transmitted by the bite of sand fly (subfamily Phlebotominae). http://purl.obolibrary.org/obo/DOID_9074 systemic lupus erythematosus http://purl.obolibrary.org/obo/DOID_8857 lupus erythematosus A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart. http://purl.obolibrary.org/obo/DOID_9098 sebaceous gland disease http://purl.obolibrary.org/obo/DOID_37 skin disease A skin disease that is located_in the sebaceous gland. http://purl.obolibrary.org/obo/DOID_9108 uterus carcinoma in situ http://purl.obolibrary.org/obo/DOID_8719 in situ carcinoma An in situ carcinoma that is located_in the uterus. http://purl.obolibrary.org/obo/DOID_9111 cutaneous leishmaniasis http://purl.obolibrary.org/obo/DOID_37 skin disease A leishmaniasis that involves skin infection caused by Leishmania species, resulting in one or more cutaneous lesions. http://purl.obolibrary.org/obo/DOID_9123 eczema herpeticum http://purl.obolibrary.org/obo/DOID_37 skin disease A herpes simplex that results_in infection located_in skin, effected by preexisting dermatosis, has_material_basis_in Human herpesvirus 1 or Human herpesvirus 2. The infection has_symptom watery blisters, has_symptom fever, and has_symptom swelling of the lymph nodes. http://purl.obolibrary.org/obo/DOID_9138 stomach carcinoma in situ http://purl.obolibrary.org/obo/DOID_8719 in situ carcinoma An in situ carcinoma that is located_in the stomach. http://purl.obolibrary.org/obo/DOID_9146 visceral leishmaniasis http://purl.obolibrary.org/obo/DOID_409 liver disease A leishmaniasis that is the most severe form of the disease caused by protozoan parasites of the Leishmania genus, resulting in the infection of the internal organs such as liver, spleen and bone marrow. The symptoms include fever, weight loss, and an enlarged spleen and liver. http://purl.obolibrary.org/obo/DOID_9155 mucocutaneous leishmaniasis http://purl.obolibrary.org/obo/DOID_974 upper respiratory tract disease A leishmaniasis that involves a chronic inflammatory process involving the nasal, pharyngeal, and laryngeal mucosa, which can lead to extensive tissue destruction, caused by protozoan parasites belonging to the genus Leishmania. The infection is characterized by granulomatous lesion which can destroy upper respiratory tract mucosa. http://purl.obolibrary.org/obo/DOID_9159 gas gangrene http://purl.obolibrary.org/obo/DOID_0080000 muscular disease A commensal bacterial infectious disease that results in infection, located in muscle tissue, has_material_basis_in Clostridium perfringens, which produce gas that becomes trapped in the infected tissue. Gas gangrene usually develops after injuries or surgery. The infection has symptom large blisters, has symptom pain in the infected area, has symptom myonecrosis, has symptom gas production, and has symptom sepsis. http://purl.obolibrary.org/obo/DOID_9164 achalasia http://purl.obolibrary.org/obo/DOID_6050 esophageal disease An esophageal disease that is characterized by an inability of the esophagus to move food toward the stomach resulting from the lower esophogeal sphincter not fully relaxing during swallowing. http://purl.obolibrary.org/obo/DOID_9169 Wiskott-Aldrich syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by abnormal immune system function and a reduced ability to form blood clots resulting from a decrease in the number and size of blood cell fragments involved in clotting (microthrombocytopenia). http://purl.obolibrary.org/obo/DOID_9181 amebiasis http://purl.obolibrary.org/obo/DOID_2789 parasitic protozoa infectious disease A parasitic protozoa infectious disease that involves infection caused by the amoeba Entamoeba histolytica. Amebic invasion of the intestinal lining causes dysentery, colitis or diarrhea. The infection can also spread through the blood to the liver and, rarely, to the lungs, brain or other organs. http://purl.obolibrary.org/obo/DOID_92 speech disorder http://purl.obolibrary.org/obo/DOID_2033 communication disorder A communication disorder that involves difficulty with the act of speech production. http://purl.obolibrary.org/obo/DOID_9201 lichen planus http://purl.obolibrary.org/obo/DOID_8574 lichen disease A lichen disease that is located_in skin, located_in tongue or located_in oral mucosa, which presents itself in the form of papules, lesions or rashes. http://purl.obolibrary.org/obo/DOID_9210 herpes zoster oticus http://purl.obolibrary.org/obo/DOID_4953 poliomyelitis A viral infectious disease that results_in inflammation located_in facial nerve, which leads to paralysis of one side of the face, has_material_basis_in Human herpesvirus 3, which reactivates after appearing as chickenpox in childhood. The infection has_symptom vesicular rash of the ear or mouth, has_symptom tinnitus, has_symptom vertigo, has_symptom otalgia, and has_symptom headache. http://purl.obolibrary.org/obo/DOID_9212 pityriasis rubra pilaris http://purl.obolibrary.org/obo/DOID_37 skin disease A skin disease that is characterized by hyperkeratotic follicular papules coalescing into orange-red scaly plaques, islands of sparing, and palmoplantar keratoderma. http://purl.obolibrary.org/obo/DOID_9220 central sleep apnea http://purl.obolibrary.org/obo/DOID_0050847 sleep apnea A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing. http://purl.obolibrary.org/obo/DOID_9230 pompholyx http://purl.obolibrary.org/obo/DOID_1383 sweat gland disease A sweat gland disease that is characterized by recurrent vesicles and bullae that develop particularly upon the lateral palms, soles, and fingers and has_symptom pruritis and cracked skin. http://purl.obolibrary.org/obo/DOID_9240 erythromelalgia http://purl.obolibrary.org/obo/DOID_870 neuropathy A neuropathy that is characterized by intense, burning pain of affected extremities, severe redness and increased skin temperature. http://purl.obolibrary.org/obo/DOID_9245 Alagille syndrome http://purl.obolibrary.org/obo/DOID_409 liver disease A liver disease that is characterized by an accumulation of bile in the liver resulting from a reducted number of liver small bile ducts. http://purl.obolibrary.org/obo/DOID_9246 cerebral amyloid angiopathy http://purl.obolibrary.org/obo/DOID_9120 amyloidosis An amyloidosis where amyloid protein progressively deposits in cerebral blood vessel walls with subsequent degenerative vascular changes that usually result in spontaneous cerebral hemorrhage, ischemic lesions and progressive dementia. http://purl.obolibrary.org/obo/DOID_9250 acrocallosal syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is an autosomal recessive disorder, which is characterized by corpus callosum agenesis, polydactyly, multiple dysmorphic features, motor and mental retardation. http://purl.obolibrary.org/obo/DOID_9254 mast-cell leukemia http://purl.obolibrary.org/obo/DOID_1240 leukemia A leukemia that results_in an overwhelming number of tissue mast cells located_in peripheral blood. http://purl.obolibrary.org/obo/DOID_9258 Waardenburg's syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by varying degrees of deafness, minor defects in structures arising from the neural crest and pigmentation anomalies of the hair, the skin and/or the iris of both eyes. http://purl.obolibrary.org/obo/DOID_9261 nasopharynx carcinoma http://purl.obolibrary.org/obo/DOID_9561 nasopharyngeal disease A pharynx cancer that is located in the nasopharynx, the uppermost region of the pharynx or throat, where the nasal passages and auditory tubes join the remainder of the upper respiratory tract. http://purl.obolibrary.org/obo/DOID_9263 homocystinuria http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder An amino acid metabolic disorder that involves an accumulation of homocysteine in the serum and an increased excretion of homocysteine in the urine. http://purl.obolibrary.org/obo/DOID_9266 cystinuria http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder An amino acid metabolic disorder that involves the formation of cystine stones in the kidneys, ureter, and bladder. http://purl.obolibrary.org/obo/DOID_9267 urea cycle disorder http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder An amino acid metabolic disorder that involves a deficiency of one of the enzymes in the urea cycle which is responsible for removing ammonia from the blood stream. http://purl.obolibrary.org/obo/DOID_9268 glycine encephalopathy http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder An amino acid metabolic disorder that involves abnormally high levels of the amino acid glycine in bodily fluids and tissues. http://purl.obolibrary.org/obo/DOID_9269 maple syrup urine disease http://purl.obolibrary.org/obo/DOID_0060159 organic acidemia An organic acidemia that is caused by a deficiency of decarboxylase leading to high concentrations of valine, leucine, isoleucine, and alloisoleucine in the blood, urine, and cerebrospinal fluid and characterized by an odor of maple syrup to the urine, vomiting, hypertonicity, severe mental retardation, seizures, and eventually death unless the condition is treated with dietary measures. http://purl.obolibrary.org/obo/DOID_9270 alkaptonuria http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder An amino acid metabolic disorder that involves phenylalanine and tyrosine metabolism with the accumulation of homogentisic acid, a toxic tyrosine byproduct. http://purl.obolibrary.org/obo/DOID_9271 ornithine carbamoyltransferase deficiency http://purl.obolibrary.org/obo/DOID_9267 urea cycle disorder An urea cycle disorder that involves a mutated and ineffective form of the enzyme ornithine transcarbamylase. http://purl.obolibrary.org/obo/DOID_9274 hyperlysinemia http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder An amino acid metabolic disorder that involves an abnormal increase of lysine in the blood. http://purl.obolibrary.org/obo/DOID_9278 hyperargininemia http://purl.obolibrary.org/obo/DOID_9267 urea cycle disorder An urea cycle disorder that involves arginase deficiency resulting in elevated levels of plasma arginine. http://purl.obolibrary.org/obo/DOID_9279 hyperhomocysteinemia http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder An amino acid metabolic disorder that involves an abnormally large level of homocysteine in the blood. http://purl.obolibrary.org/obo/DOID_9280 carbamoyl phosphate synthetase I deficiency disease http://purl.obolibrary.org/obo/DOID_0050737 autosomal recessive disease A urea cycle disorder that involves accumulation of ammonia in the blood. http://purl.obolibrary.org/obo/DOID_9281 phenylketonuria http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder An amino acid metabolic disorder that is characterized by a mutation in the gene for the hepatic enzyme phenylalanine hydroxylase (PAH), rendering it nonfunctional. http://purl.obolibrary.org/obo/DOID_9282 ocular hypertension http://purl.obolibrary.org/obo/DOID_5614 eye disease An eye disease that is characterized by elevated intraocular pressure in the absence of optic nerve damage or visual field loss. http://purl.obolibrary.org/obo/DOID_9286 priapism http://purl.obolibrary.org/obo/DOID_341 peripheral vascular disease A peripheral vascular disease characterized by blood trapped in the penis that is unable to drain. http://purl.obolibrary.org/obo/DOID_9296 cleft lip http://purl.obolibrary.org/obo/DOID_9297 lip disease An orofacial cleft that is characterized by a congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. http://purl.obolibrary.org/obo/DOID_9317 lymphangitis http://purl.obolibrary.org/obo/DOID_75 lymphatic system disease A lymphatic system disease that is characterized by inflammation of the lymphatic channels which occurs as a result of infection at a site distal to the channel. It is caused by Streptococcus pyogenes (Group A strep) or Staphylococcus aureus. Lymphangitis is also sometimes called blood poisoning. http://purl.obolibrary.org/obo/DOID_9362 status asthmaticus http://purl.obolibrary.org/obo/DOID_0080810 acute asthma An acute asthma that is characterized by an acute episode with a progressive severity that is poorly responsive to standard therapeutic measures, regardless of disease severity or phenotypic variant. http://purl.obolibrary.org/obo/DOID_9370 exophthalmos http://purl.obolibrary.org/obo/DOID_5614 eye disease An eye disease that is characterized by a bulging of the eye anteriorly out of the orbit. http://purl.obolibrary.org/obo/DOID_9375 Fuchs' heterochromic uveitis http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is a chronic unilateral (or rarely bilateral) iridocyclitis appearing with the triad of heterochromia, predisposition to cataracts and glaucoma, and keratitic percipitates on the posterior corneal surface. http://purl.obolibrary.org/obo/DOID_9392 tracheitis http://purl.obolibrary.org/obo/DOID_3225 tracheal disease A tracheal disease which involves bacterial infection of the trachea often caused by Staphylococcus aureus and streptococci that follows a recent viral upper respiratory infection. The symptoms include barking croup cough, loud squeaking noise while breathing, scratchy feeling in the throat, high fever, and production of large amounts of pus-filled secretions. http://purl.obolibrary.org/obo/DOID_9395 croup http://purl.obolibrary.org/obo/DOID_1579 respiratory system disease A respiratory system infectious disease that involves inflammation, edema, and subsequent obstruction of the larynx, trachea, and bronchi. The disease is caused by viruses, bacteria, allergies and inhaled irritants. It is marked by episodes of difficult breathing and hoarse metallic cough in infants and young children. Croup is caused by parainfluenza virus (types 1 and 2), Influenza A and B viruses, Measles virus, adenovirus, respiratory syncytial virus, Staphylococcus and Streptococcus. http://purl.obolibrary.org/obo/DOID_9398 epiglottitis http://purl.obolibrary.org/obo/DOID_974 upper respiratory tract disease An upper respiratory tract disease which involves inflammation of the epiglottis due to infection. Haemophilus influenzae type B is the most common bacterial causative agent, although some cases are attributable to Streptococcus pneumoniae or Streptococcus pyogenes. The infection can cause the epiglottis to either obstruct or completely close off the windpipe. Epiglottitis typically affects children, and is associated with fever, difficulty in swallowing, drooling, hoarseness of voice, and stridor. http://purl.obolibrary.org/obo/DOID_9452 fatty liver disease http://purl.obolibrary.org/obo/DOID_9455 lipid storage disease A lipid storage disease characterized by the accumulation of large vacuoles of triglyceride fat in liver cells via the process of steatosis. http://purl.obolibrary.org/obo/DOID_9467 nail-patella syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by nail dysplasia and absent or hypoplastic patellae that has_material_basis_in heterozygous mutation in LMX1B on chromosome 9q33.3. http://purl.obolibrary.org/obo/DOID_9477 pulmonary embolism http://purl.obolibrary.org/obo/DOID_60001 pulmonary artery disease An artery disease characterized by a blockage of the main artery of the lung or one of its branches by a substance that has travelled from elsewhere in the body, e.g. a blood clot. http://purl.obolibrary.org/obo/DOID_9505 cannabis abuse http://purl.obolibrary.org/obo/DOID_302 substance abuse A substance abuse that involves the recurring use of cannabis despite negative consequences. http://purl.obolibrary.org/obo/DOID_9507 ethmoid sinusitis http://purl.obolibrary.org/obo/DOID_0050127 sinusitis A sinusitis which involves infection of ethmoid sinuses that causes pain or pressure behind and between the eyes, tearing, and headache over the forehead. http://purl.obolibrary.org/obo/DOID_9521 Laron syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by marked short stature with normal or high serum growth hormone and low serum insulin-like growth factor-1 levels that has_material_basis_in homozygous or compound heterozygous mutation in GHR on chromosome 5p13-p12. http://purl.obolibrary.org/obo/DOID_9531 latent syphilis http://purl.obolibrary.org/obo/DOID_4166 syphilis A syphilis that is characterized as having serologic proof of infection without signs or symptoms of disease. http://purl.obolibrary.org/obo/DOID_9537 Lassa fever http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in infection, has_material_basis_in Lassa virus, which is transmitted_by multimammate rat of the genus Mastomys. The infection has_symptom fever, has_symptom retrosternal pain, has_symptom sore throat, has_symptom back pain, has_symptom cough, has_symptom abdominal pain, has_symptom vomiting, has_symptom diarrhea, has_symptom conjunctivitis, has_symptom facial swelling, has_symptom proteinuria (protein in the urine), and has_symptom mucosal bleeding. http://purl.obolibrary.org/obo/DOID_9538 multiple myeloma http://purl.obolibrary.org/obo/DOID_9500 leukocyte disease A myeloid neoplasm that is located_in the plasma cells in bone marrow. http://purl.obolibrary.org/obo/DOID_9563 bronchiectasis http://purl.obolibrary.org/obo/DOID_1176 bronchial disease A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances. http://purl.obolibrary.org/obo/DOID_9577 neonatal candidiasis http://purl.obolibrary.org/obo/DOID_1508 candidiasis A candidiasis that involves fungal infection in neonates caused by Candida species. Low birthweight and age, prolonged intravascular catheterization and the use of antibiotic drugs are the principle predisposing conditions for systemic candidiasis in neonates. http://purl.obolibrary.org/obo/DOID_9584 Venezuelan equine encephalitis http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Venezuelan equine encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom fever, has_symptom chills, has_symptom malaise, has_symptom severe headache, has_symptom photophobia, and has_symptom myalgia in the legs and lumbosacral region. http://purl.obolibrary.org/obo/DOID_9598 fasciitis http://purl.obolibrary.org/obo/DOID_65 connective tissue disease A connective tissue disease characterized by inflammation located in the fascia. http://purl.obolibrary.org/obo/DOID_96 staphyloenterotoxemia http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that results_in infection located_in intestine caused by eating food contaminated with enterotoxins produced by bacteria, has_material_basis_in Staphylococcus aureus. The infection has_symptom diarrhea, has_symptom vomiting, has_symptom nausea, has_symptom cramps, and has_symptom weakness. http://purl.obolibrary.org/obo/DOID_9620 vesicoureteral reflux http://purl.obolibrary.org/obo/DOID_1426 ureteral disease A ureteral disease characterized by backward flow of urine from the urinary bladder into the ureter. http://purl.obolibrary.org/obo/DOID_9631 Pelger-Huet anomaly http://purl.obolibrary.org/obo/DOID_74 hematopoietic system disease A hematopoietic system disease characterized by white blood cells with unusually shaped nuclei that has_material_basis_in heterozygous mutation in LBR on chromosome 1q42.12. http://purl.obolibrary.org/obo/DOID_9640 sarcocystosis http://purl.obolibrary.org/obo/DOID_2113 coccidiosis A coccidiosis that involves infection of the intestine and muscles of humans and animals caused by an intracellular protozoan parasite of genus Sarcocystis. The symptoms include mild fever, diarrhea, chills, vomiting, muscle swelling, erythema, muscle tenderness,cough, arthralgia, transient pruritic rashes, headache, malaise and lymphadenopathy. http://purl.obolibrary.org/obo/DOID_9643 babesiosis http://purl.obolibrary.org/obo/DOID_2789 parasitic protozoa infectious disease A parasitic protozoa infectious disease that has_symptom mild fevers and has_symptom anemia described as malaria-like symptoms caused by a protozoan of genus Babesia, which reproduce in red blood cells and cause hemolytic anemia. They are transmitted by Ixodid ticks or by blood transfusion. Babesiosis is a zoonotic disease. http://purl.obolibrary.org/obo/DOID_9649 congenital nystagmus http://purl.obolibrary.org/obo/DOID_9650 pathologic nystagmus A pathologic nystagmus, present at birth, characterized by involuntary, rhythmic eye movements; oscillations are usually horizontal in direction. http://purl.obolibrary.org/obo/DOID_9663 aphthous stomatitis http://purl.obolibrary.org/obo/DOID_9637 stomatitis A stomatitis characterized by the repeated formation of benign and non-contagious mouth ulcers. http://purl.obolibrary.org/obo/DOID_9667 placental abruption http://purl.obolibrary.org/obo/DOID_780 placenta disease A placenta disease that is characterized by separation of the placental lining from the uterus of the mother. http://purl.obolibrary.org/obo/DOID_9681 cervical incompetence http://purl.obolibrary.org/obo/DOID_2253 cervix disease A cervix disease that is characterized by the beginning of dilation and effacement of a pregnant woman's cervix before her pregnancy has reached term. http://purl.obolibrary.org/obo/DOID_9682 yellow fever http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results in infection, has_material_basis_in Yellow fever virus, which is transmitted by Aedes, transmitted by Haemagogus, or transmitted by Sabethes species of mosquitoes. The infection has symptom fever, has symptom muscle pain, has symptom backache, has symptom headache, has symptom shivers, has symptom loss of appetite, has symptom jaundice, and has symptom bleeding from the mouth, nose, eyes or stomach leading to vomitus containing blood. http://purl.obolibrary.org/obo/DOID_9699 ophthalmia neonatorum http://purl.obolibrary.org/obo/DOID_9700 bacterial conjunctivitis A bacterial conjuctivitis that is characterized by pain and tenderness in the eyeball and conjuctival discharge. http://purl.obolibrary.org/obo/DOID_9719 neovascular inflammatory vitreoretinopathy http://purl.obolibrary.org/obo/DOID_9720 vitreous disease A retinal and vitreous disease characterized by ocular inflammation, vascular dropout, large spots of hyperpigmentation, neovascularization of the peripheral and posterior retina, vitreous hemorrhage, and retinal detachment that has_material_basis_in heterozygous mutation in CAPN5 on chromosome 11q13.5. http://purl.obolibrary.org/obo/DOID_9733 renal tuberculosis http://purl.obolibrary.org/obo/DOID_557 kidney disease An urogenital tuberculosis that results_in formation of granulomas located_in kidney. http://purl.obolibrary.org/obo/DOID_9765 emphysematous cholecystitis http://purl.obolibrary.org/obo/DOID_1949 cholecystitis Emphysematous cholecystitis is a bacterial infectious disease consisting of an inflammation of the gallbladder characterized by air-filled expansions in interstitial or subcutaneous tissues. http://purl.obolibrary.org/obo/DOID_9778 irritable bowel syndrome http://purl.obolibrary.org/obo/DOID_5295 intestinal disease An intestinal disease that is characterized by chronic abdominal pain, discomfort, bloating, and alteration of bowel habits in the absence of any detectable organic cause. http://purl.obolibrary.org/obo/DOID_9784 trichinosis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that involves parasitic infection of animals and humans by Trichinella spiralis, Trichinella nativa or Trichinella britovi. Intestinal invasion causes diarrhea, abdominal pain and vomiting. Larval migration into muscle tissues can cause periorbital and facial edema, conjunctivitis, fever, myalgias, splinter hemorrhages, rashes, and blood eosinophilia. Myocarditis, central nervous system involvement, and pneumonitis can also occur. http://purl.obolibrary.org/obo/DOID_9790 toxocariasis http://purl.obolibrary.org/obo/DOID_936 brain disease A parasitic helminthiasis infectious disease that involves zoonotic infection of humans by the larvae of Toxocara canis or Toxocara cati. The larvae invade multiple tissues like liver, heart, lungs, brain, muscle and eyes causing various symptoms including fever, anorexia, weight loss, cough, wheezing, rashes, hepatosplenomegaly, hypereosinophilia and ophthalmologic lesions. http://purl.obolibrary.org/obo/DOID_9808 Goodpasture syndrome http://purl.obolibrary.org/obo/DOID_850 lung disease An autoimmune disease that is characterized by antibody attack of the basement membrane in lungs and kidneys, leading to bleeding from the lungs and kidney failure. http://purl.obolibrary.org/obo/DOID_9810 polyarteritis nodosa http://purl.obolibrary.org/obo/DOID_865 vasculitis A vasculitis that is characterized by necrotizing inflammation of medium or small arteries. http://purl.obolibrary.org/obo/DOID_9828 neonatal abstinence syndrome http://purl.obolibrary.org/obo/DOID_0060001 withdrawal disorder A withdrawal disorder that is characterized by a group of problems that occur in a newborn who was exposed to addictive illegal or prescription drugs while in the mother's womb or postnatally following the discontinuance of drug treatment. http://purl.obolibrary.org/obo/DOID_988 mitral valve prolapse http://purl.obolibrary.org/obo/DOID_61 mitral valve disease A mitral valve disease where one or both of the cusps of the mitral valve bulge or collapse backward in the left atrium during systole. http://purl.obolibrary.org/obo/DOID_9883 Becker muscular dystrophy http://purl.obolibrary.org/obo/DOID_9884 muscular dystrophy A muscular dystrophy that involves slowly worsening muscle weakness of the legs and pelvis, and has_material_basis in X-linked recessive inheritance of mutation in the dystrophin gene on chromosome Xp21. http://purl.obolibrary.org/obo/DOID_990 congenital heart block http://purl.obolibrary.org/obo/DOID_0080015 physical disorder An atrioventricular block characterized by the presence of conduction system disease of any form, which is diagnosed on or before 28 days of life. http://purl.obolibrary.org/obo/DOID_9909 hordeolum http://purl.obolibrary.org/obo/DOID_530 eyelid disease Hordeolum is a sequelae of infectious and parasitic disease consisting of an infection of the sebaceous glands at the base of the eyelashes. Styes are generally caused by a Staphylococcus aureus bacterial infection. http://purl.obolibrary.org/obo/DOID_9923 developmental coordination disorder http://purl.obolibrary.org/obo/DOID_0060038 specific developmental disorder A specific developmental disorder that involves disordered motor skills where coordinated muscle movement is impaired. http://purl.obolibrary.org/obo/DOID_9931 Waterhouse-Friderichsen syndrome http://purl.obolibrary.org/obo/DOID_9553 adrenal gland disease An adrenal gland disease that is characterized by failure of the adrenal gland due to bleeding into the gland. http://purl.obolibrary.org/obo/DOID_9935 chronic inflammation of lacrimal passage http://purl.obolibrary.org/obo/DOID_1400 lacrimal apparatus disease A lacrimal apparatus disease that is characterized by longstanding inflammation of the lacrimal passage, and has_symptom pain, increased or decreased tearing, and swelling between the eye and nose. http://purl.obolibrary.org/obo/DOID_9946 steroid-induced glaucoma http://purl.obolibrary.org/obo/DOID_1686 glaucoma A glaucoma characterized by elevated intraocular pressure secondary to chronic corticosteroid use, which leads to glaucomatous optic nerve atrophy and progressive vision loss and has_symptom progressive decreased vision, visual field defects, and decreased peripheral vision. Steroid-induced glaucoma is caused by chronic corticosteroid use. http://purl.obolibrary.org/obo/DOID_9955 hypoplastic left heart syndrome http://purl.obolibrary.org/obo/DOID_1682 congenital heart disease A congenital heart disease characterized by abnormal development of the left-sided structures of the heart. http://purl.obolibrary.org/obo/DOID_9958 hemometra http://purl.obolibrary.org/obo/DOID_345 uterine disease A uterine disease that is characterized by the presence of blood in the uterine cavity. http://purl.obolibrary.org/obo/DOID_997 uterine inversion http://purl.obolibrary.org/obo/DOID_345 uterine disease A uterine disease that is characterized by the uterine cavity turning inside out as a complication of childbirth. http://purl.obolibrary.org/obo/DOID_9971 hypervitaminosis D http://purl.obolibrary.org/obo/DOID_654 overnutrition An overnutrition that is characterized by elevated vitamin D, which can subsequently cause high levels of calcium, has_symptom myalgia, fatigue, irritability, nausea, dehydration, polyuria, and nephrocalcinosis, and possibly has_material_basis_in excess intake of vitamin D. http://purl.obolibrary.org/obo/DOID_9974 drug dependence http://purl.obolibrary.org/obo/DOID_9973 substance dependence A substance dependence that involves the continued use of drugs despite problems related to use of the substance. http://purl.obolibrary.org/obo/DOID_9975 cocaine dependence http://purl.obolibrary.org/obo/DOID_9974 drug dependence A drug dependence that is a psychological dependency on the regular use of cocaine. http://purl.obolibrary.org/obo/DOID_9976 heroin dependence http://purl.obolibrary.org/obo/DOID_2559 opiate dependence An opiate dependence that involves the continued use of heroin despite problems related to use of the substance. http://purl.obolibrary.org/obo/DOID_9977 hallucinogen dependence http://purl.obolibrary.org/obo/DOID_9974 drug dependence A drug dependence that involves the continued use of hallucinogenic drugs despite problems related to use of the substance. http://purl.obolibrary.org/obo/DOID_999 hypereosinophilic syndrome http://purl.obolibrary.org/obo/DOID_9500 leukocyte disease A leukocyte disease that is characterized by high numbers of eosinophils which over time enter various tissues, eventually damaging organs. http://purl.obolibrary.org/obo/DOID_9993 hypoglycemia http://purl.obolibrary.org/obo/DOID_4194 glucose metabolism disease A glucose metabolism disease that is characterized by abnormally low levels of blood glucose. http://purl.obolibrary.org/obo/UBERON_0000002 uterine cervix http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity Lower, narrow portion of the uterus where it joins with the top end of the vagina. http://purl.obolibrary.org/obo/UBERON_0000473 testis http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity A gonad of a male animal. A gonad produces and releases sperm. http://purl.obolibrary.org/obo/UBERON_0001264 pancreas http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes[GO]. http://purl.obolibrary.org/obo/UBERON_0002369 adrenal gland http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity Either of a pair of complex endocrine organs near the anterior medial border of the kidney consisting of a mesodermal cortex that produces glucocorticoid, mineralocorticoid, and androgenic hormones and an ectodermal medulla that produces epinephrine and norepinephrine[BTO]. http://purl.obolibrary.org/obo/UBERON_0002385 muscle tissue http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]. http://purl.obolibrary.org/obo/CLO_0000001 细胞系细胞 http://www.bioassayontology.org/bao#BAO_0003114 assay biology component A cultured cell that is part of a cell line - a stable and homogeneous population of cells with a common biological origin and propagation history in culture http://purl.obolibrary.org/obo/CLO_0000031 细胞系 http://www.bioassayontology.org/bao#BAO_0003114 assay biology component 一个培养细胞群体，其代表具有共同增殖历史（即已经在培养中一起连续传代）的遗传稳定且同质的培养细胞群体。 http://purl.obolibrary.org/obo/PATO_0000011 age http://purl.obolibrary.org/obo/PATO_0000165 time A time quality inhering in a bearer by virtue of how long the bearer has existed. http://purl.obolibrary.org/obo/PATO_0000047 biological sex http://purl.obolibrary.org/obo/PATO_0001995 organismal quality An organismal quality inhering in a bearer by virtue of the bearer's ability to undergo sexual reproduction in order to differentiate the individuals or types involved. http://purl.obolibrary.org/obo/PATO_0000122 length http://purl.obolibrary.org/obo/PATO_0001708 1-D extent A 1-D extent quality which is equal to the distance between two points. http://purl.obolibrary.org/obo/PATO_0000383 female http://purl.obolibrary.org/obo/PATO_0000047 biological sex A biological sex quality inhering in an individual or a population that only produces gametes that can be fertilised by male gametes. http://purl.obolibrary.org/obo/PATO_0000384 male http://purl.obolibrary.org/obo/PATO_0000047 biological sex A biological sex quality inhering in an individual or a population whose sex organs contain only male gametes. http://purl.obolibrary.org/obo/PATO_0000918 volume http://purl.obolibrary.org/obo/PATO_0001710 3-D extent A 3-D extent quality inhering in a bearer by virtue of the bearer's amount of 3-dimensional space it occupies. http://purl.obolibrary.org/obo/PATO_0001396 cellular quality http://www.bioassayontology.org/bao#BAO_0002928 quality A monadic quality of continuant that exists at the cellular level of organisation. http://purl.obolibrary.org/obo/PATO_0001995 organismal quality http://www.bioassayontology.org/bao#BAO_0002928 quality A quality that inheres in an entire organism or part of an organism. http://purl.obolibrary.org/obo/UO_0000001 length unit http://www.bioassayontology.org/bao#BAO_0000077 unit of measurement A unit which is a standard measure of the distance between two points. http://purl.obolibrary.org/obo/UO_0000003 time unit http://www.bioassayontology.org/bao#BAO_0000077 unit of measurement A unit which is a standard measure of the dimension in which events occur in sequence. http://purl.obolibrary.org/obo/UO_0000005 temperature unit http://www.bioassayontology.org/bao#BAO_0000077 unit of measurement A unit which is a standard measure of the average kinetic energy of the particles in a sample of matter. http://purl.obolibrary.org/obo/UO_0000008 meter http://purl.obolibrary.org/obo/UO_0000001 length unit A length unit which is equal to the length of the path traveled by light in vacuum during a time interval of 1/299 792 458 of a second. http://purl.obolibrary.org/obo/UO_0000010 second http://purl.obolibrary.org/obo/UO_0000003 time unit A time unit which is equal to the duration of 9 192 631 770 periods of the radiation corresponding to the transition between the two hyperfine levels of the ground state of the caesium 133 atom. http://purl.obolibrary.org/obo/UO_0000015 centimeter http://purl.obolibrary.org/obo/UO_0000001 length unit A length unit which is equal to one hundredth of a meter or 10^[-2] m. http://purl.obolibrary.org/obo/UO_0000016 millimeter http://purl.obolibrary.org/obo/UO_0000001 length unit A length unit which is equal to one thousandth of a meter or 10^[-3] m. http://purl.obolibrary.org/obo/UO_0000017 micrometer http://purl.obolibrary.org/obo/UO_0000001 length unit A length unit which is equal to one millionth of a meter or 10^[-6] m. http://purl.obolibrary.org/obo/UO_0000018 nanometer http://purl.obolibrary.org/obo/UO_0000001 length unit A length unit which is equal to one thousandth of one millionth of a meter or 10^[-9] m. http://purl.obolibrary.org/obo/UO_0000019 angstrom http://purl.obolibrary.org/obo/UO_0000001 length unit A length unit which is equal to 10 [-10] m. http://purl.obolibrary.org/obo/UO_0000027 degree Celsius http://purl.obolibrary.org/obo/UO_0000005 temperature unit A temperature unit which is equal to one kelvin degree. However, they have their zeros at different points. The centigrade scale has its zero at 273.15 K. http://purl.obolibrary.org/obo/UO_0000031 minute http://purl.obolibrary.org/obo/UO_0000003 time unit A time unit which is equal to 60 seconds. http://purl.obolibrary.org/obo/UO_0000032 hour http://purl.obolibrary.org/obo/UO_0000003 time unit A time unit which is equal to 3600 seconds or 60 minutes. http://purl.obolibrary.org/obo/UO_0000033 day http://purl.obolibrary.org/obo/UO_0000003 time unit A time unit which is equal to 24 hours. http://purl.obolibrary.org/obo/UO_0000034 week http://purl.obolibrary.org/obo/UO_0000003 time unit A time unit which is equal to 7 days. http://purl.obolibrary.org/obo/UO_0000035 month http://purl.obolibrary.org/obo/UO_0000003 time unit A time unit which is approximately equal to the length of time of one of cycle of the moon's phases which in science is taken to be equal to 30 days. http://purl.obolibrary.org/obo/UO_0000036 year http://purl.obolibrary.org/obo/UO_0000003 time unit A time unit which is equal to 12 months which in science is taken to be equal to 365.25 days. http://purl.obolibrary.org/obo/UO_0000051 concentration unit http://www.bioassayontology.org/bao#BAO_0000077 unit of measurement A unit which represents a standard measurement of how much of a given substance there is mixed with another substance. http://purl.obolibrary.org/obo/UO_0000062 molar http://purl.obolibrary.org/obo/UO_0000061 unit of molarity A unit of concentration which expresses a concentration of 1 mole of solute per liter of solution (mol/L). http://purl.obolibrary.org/obo/UO_0000063 millimolar http://purl.obolibrary.org/obo/UO_0000061 unit of molarity A unit of molarity which is equal to one thousandth of a molar or 10^[-3] M. http://purl.obolibrary.org/obo/UO_0000064 micromolar http://purl.obolibrary.org/obo/UO_0000061 unit of molarity A unit of molarity which is equal to one millionth of a molar or 10^[-6] M. http://purl.obolibrary.org/obo/UO_0000065 nanomolar http://purl.obolibrary.org/obo/UO_0000061 unit of molarity A unit of molarity which is equal to one thousandth of one millionth of a molar or 10^[-9] M. http://purl.obolibrary.org/obo/UO_0000066 picomolar http://purl.obolibrary.org/obo/UO_0000061 unit of molarity A unit of molarity which is equal to 10^[-12] M. http://purl.obolibrary.org/obo/UO_0000105 frequency unit http://www.bioassayontology.org/bao#BAO_0000077 unit of measurement A unit which is a standard measure of the number of repetitive actions in a particular time. http://purl.obolibrary.org/obo/UO_0000106 hertz http://purl.obolibrary.org/obo/UO_0000105 frequency unit A frequency unit which is equal to 1 complete cycle of a recurring phenomenon in 1 second. http://purl.obolibrary.org/obo/UO_0000163 mass percentage http://purl.obolibrary.org/obo/UO_0000051 concentration unit A dimensionless concentration unit which denotes the mass of a substance in a mixture as a percentage of the mass of the entire mixture. http://purl.obolibrary.org/obo/UO_0000196 pH http://purl.obolibrary.org/obo/UO_0000051 concentration unit A dimensionless concentration notation which denotes the acidity of a solution in terms of activity of hydrogen ions (H+). http://www.bioassayontology.org/bao#BAO_0000588 50 percent cytotoxicity http://www.bioassayontology.org/bao#BAO_0000006 percent cytotoxicity The perturbagen mediated 50% of cells to die in an assay. http://purl.obolibrary.org/obo/DOID_0090070 hypogonadotropic hypogonadism http://purl.obolibrary.org/obo/DOID_1924 hypogonadism A hypogonadism characterized by a impaired signalling by gonadotrpin relasing hormone. http://www.bioassayontology.org/bao#BAO_0002862 EC 5 hour http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint The concentration of compound that elicits an extension of circadian period length by 5 hours. http://www.bioassayontology.org/bao#BAO_0002886 ECMax_fold increase http://www.bioassayontology.org/bao#BAO_0002883 ECMax The compound concentration whereupon perceived activity (fold increase) reaches the maximum value observed (with a positive control). http://purl.obolibrary.org/obo/DOID_0070313 thiamine deficiency disease http://purl.obolibrary.org/obo/DOID_5113 nutritional deficiency disease A nutritional deficiency disease that is characterized by low levels of thiamine. http://purl.obolibrary.org/obo/DOID_0070329 mitochondrial DNA depletion syndrome http://purl.obolibrary.org/obo/DOID_700 mitochondrial metabolism disease A mitochondrial metabolism disease that is characterized by significant reduction in mitochondrial DNA in affected tissues, resulting in impaired mtDNA-encoded protein synthesis and energy production in the affected tissues and organs. http://purl.obolibrary.org/obo/DOID_0014667 disease of metabolism http://purl.obolibrary.org/obo/DOID_4 disease A disease that involving errors in metabolic processes of building or degradation of molecules. http://purl.obolibrary.org/obo/DOID_0050012 chikungunya http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in infection located_in joint, has_material_basis_in Chikungunya virus, which is transmitted_by Aedes mosquito bite. The infection has_symptom fever, has_symptom arthralgia, and has_symptom maculopapular rash. http://purl.obolibrary.org/obo/DOID_0050013 carbohydrate metabolism disease http://purl.obolibrary.org/obo/DOID_0060158 acquired metabolic disease An acquired metabolic disease that is characterized by abnormal carbohydrate metabolism. http://purl.obolibrary.org/obo/DOID_0050025 human granulocytic anaplasmosis http://purl.obolibrary.org/obo/DOID_10242 ehrlichiosis An ehrlichiosis that results in infection located in granular leukocyte, has_material_basis_in Anaplasma phagocytophilum, which is transmitted by lone start tick (Amblyomma americanum ). The infection has symptom headache, has symptom muscle aches, has symptom fatigue, has symptom fever and has symptom rash. http://purl.obolibrary.org/obo/DOID_0050026 human monocytic ehrlichiosis http://purl.obolibrary.org/obo/DOID_10242 ehrlichiosis An ehrlichiosis that results in infection located in monocyte or located in macrophage, has_material_basis_in Ehrlichia chaffeensis, which is transmitted by black-legged tick (Ixodes scapularis), transmitted by western black-legged tick (Ixodes pacificus) or transmitted by castor bean tick (Ixodes ricinus). The infection has symptom headache, has symptom muscle aches, has symptom fatigue, has symptom fever and has symptom rash. http://purl.obolibrary.org/obo/DOID_0050032 mineral metabolism disease http://purl.obolibrary.org/obo/DOID_0060158 acquired metabolic disease An acquired metabolic disease that is characterized by abnormal mineral metabolism. http://purl.obolibrary.org/obo/DOID_0050035 African tick-bite fever http://purl.obolibrary.org/obo/DOID_11104 spotted fever A spotted fever that has_material_basis_in Rickettsia africae, which is transmitted_by ticks (Amblyomma hebraeum and Amblyomma variegatum). The infection has_symptom fever, has_symptom eschar and has_symptom maculopapular rash. http://purl.obolibrary.org/obo/DOID_0050046 Far Eastern spotted fever http://purl.obolibrary.org/obo/DOID_11104 spotted fever A spotted fever that has_material_basis_in Rickettsia heilongjiangensis, which is transmitted_by ticks (Haemaphysalis concinna). The infection has_symptom fever, has_symptom eschar, has_symptom maculopapular rash, and has_symptom regional adenopathy. http://purl.obolibrary.org/obo/DOID_0050050 Japanese spotted fever http://purl.obolibrary.org/obo/DOID_11104 spotted fever A spotted fever that has_material_basis_in Rickettsia japonica, which is transmitted_by ticks (Dermacentor taiwanensis and Haemaphysalis flava). The infection has_symptom fever, has_symptom eschars, has_symptom regional adenopathy, and has_symptom rash on extremities. http://purl.obolibrary.org/obo/DOID_0050061 erysipeloid http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that results_in infection located_in skin, has_material_basis_in Erysipelothrix rhusiopathiae, which is transmitted_by contact with infected animals. The infection has_symptom redness of skin, has_symptom tenderness of skin and has_symptom warmth of skin. http://purl.obolibrary.org/obo/DOID_0050072 adiaspiromycosis http://purl.obolibrary.org/obo/DOID_850 lung disease A primary systemic mycosis that is a fungal infection located_in lungs, or located_in skin, which results_in disseminated granulomatous pulmonary process and cutaneous infection in rodents, small wild mammals and humans, has_material_basis_in Chrysosporium parvum or Emmonsia crescens. http://purl.obolibrary.org/obo/DOID_0050073 invasive aspergillosis http://purl.obolibrary.org/obo/DOID_850 lung disease An aspergillosis that is a serious fungal infection of the lung with pneumonia caused by Aspergillus, which spreads to other parts of the body through bloodstream in patients with acute leukemia and recipients of tissue transplants. Clinical symptoms include pulmonary nodules and hemorrhage. http://purl.obolibrary.org/obo/DOID_0050083 Keshan disease http://purl.obolibrary.org/obo/DOID_5113 nutritional deficiency disease A nutritional deficiency that is disease characterized by a cardiomyopathy secondary to selenium deficiency. http://purl.obolibrary.org/obo/DOID_0050117 disease by infectious agent http://purl.obolibrary.org/obo/DOID_4 disease A disease that is the consequence of the presence of pathogenic microbial agents, including pathogenic viruses, pathogenic bacteria, fungi, protozoa, multicellular parasites, and aberrant proteins known as prions. http://purl.obolibrary.org/obo/DOID_0050118 La Crosse encephalitis http://purl.obolibrary.org/obo/DOID_936 brain disease A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in La Crosse virus, which is transmitted_by treehole mosquito, Ochlerotatus triseriatus. The infection has_symptom seizures, has_symptom headache, has_symptom fever, has_symptom coma, and has_symptom paralysis. http://purl.obolibrary.org/obo/DOID_0050120 hemophagocytic lymphohistiocytosis http://purl.obolibrary.org/obo/DOID_75 lymphatic system disease A lymphatic system disease that is characterized by an expansion of the monocyte-macrophage population and intense hemophagocytosis. It can occur de novo, but more often occurs in the setting of another disorder, usually an infection or a malignancy. A clinical picture of fever, hepatosplenomegaly, lymphadenopathy and peripheral pancytopenia. The morphologic hallmark of this syndrome is the phagocytosis of hematopoietic elements by morphologically normal macrophages. http://purl.obolibrary.org/obo/DOID_0050127 sinusitis http://purl.obolibrary.org/obo/DOID_1352 paranasal sinus disease A paranasal sinus disease involving inflammation of the paranasal sinuses resulting from bacterial, fungal, viral infection, allergic or autoimmune issues. Symptoms can include fever, weakness, fatigue, cough and congestion. There may also be mucus drainage in the back of the throat, called postnasal drip. http://purl.obolibrary.org/obo/DOID_0050129 secretory diarrhea http://purl.obolibrary.org/obo/DOID_13250 diarrhea Secretory diarrhea is a diarrhea where there is an increase in the active secretion, or there is an inhibition of absorption causing little to no structural damage. The most common cause of this type of diarrhea is a cholera toxin that stimulates the secretion of anions, especially chloride ions. http://purl.obolibrary.org/obo/DOID_0050133 superficial mycosis http://purl.obolibrary.org/obo/DOID_1564 fungal infectious disease A fungal infectious disease that results_in infection of the outermost layer located_in skin or located_in hair shaft, has_material_basis_in Fungi. No living tissue is invaded and there is no cellular response from the host. http://purl.obolibrary.org/obo/DOID_0050134 cutaneous mycosis http://purl.obolibrary.org/obo/DOID_1564 fungal infectious disease A fungal infectious disease that results_in infection of the keratinized layers located_in skin, located_in hair or located_in nail, which extends deeper into the epidermis, has_material_basis_in Fungi and results_in_formation_of skin lesions. http://purl.obolibrary.org/obo/DOID_0050135 subcutaneous mycosis http://purl.obolibrary.org/obo/DOID_37 skin disease A fungal infectious disease that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Fungi, which penetrate the dermis or even deeper during or after a skin trauma. http://purl.obolibrary.org/obo/DOID_0050136 systemic mycosis http://purl.obolibrary.org/obo/DOID_1564 fungal infectious disease A fungal infectious disease that results_in infection of internal organs and tissues located_in human body, has_material_basis_in Fungi, which enter the body via the respiratory tract, through the gut, paranasal sinuses or skin and spread through the bloodstream to multiple organs. http://purl.obolibrary.org/obo/DOID_0050140 acute diarrhea http://purl.obolibrary.org/obo/DOID_13250 diarrhea A diarrhea that is of rapid onset and course characterized by frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. http://purl.obolibrary.org/obo/DOID_0050141 intestinal botulism http://purl.obolibrary.org/obo/DOID_11976 botulism A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) in adults, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F, which are transmitted by ingestion of bacterial spores, which then grow in the intestine and release toxins. http://purl.obolibrary.org/obo/DOID_0050145 adenoiditis http://purl.obolibrary.org/obo/DOID_974 upper respiratory tract disease An upper respiratory tract disease which involves inflammation, pain, and swelling of the adenoid tissue due to the infection by bacteria and viruses. It occurs primarily in children and may be secondary to an allergy, infection of nose or throat and an obstruction of the eustachian tube. The infection has symptom pain, has symptom redness, has symptom swelling, and has symptom difficulty swallowing. http://purl.obolibrary.org/obo/DOID_0050147 otomycosis http://purl.obolibrary.org/obo/DOID_9463 otitis externa An otitis externa which is a disease of the ear produced by the growth of fungi in the external auditory canal. It is characterized by inflammation, pruritus, scaling and severe discomfort. The most common fungi are Aspergillus niger and Candida albicans. http://purl.obolibrary.org/obo/DOID_0050148 laryngotracheitis http://purl.obolibrary.org/obo/DOID_974 upper respiratory tract disease An upper respiratory tract disease involving inflammation of both larynx and trachea often caused by viral infection. The infection can close off the windpipe. http://purl.obolibrary.org/obo/DOID_0050150 Pontiac fever http://purl.obolibrary.org/obo/DOID_10458 legionellosis A legionellosis that involves a milder respiratory illness without pneumonia. Symptoms include fever, headache and muscle aches which last for 2 to 5 days. http://purl.obolibrary.org/obo/DOID_0050152 aspiration pneumonia http://purl.obolibrary.org/obo/DOID_874 bacterial pneumonia A bacterial pneumonia which is an acute pulmonary inflammatory response that develops after the inhalation of colonized oropharyngeal material containing bacteria. It is seen in individuals with dysphagia and gastric dysmotility. The disease has_symptom tachypnea and has_symptom cough. http://purl.obolibrary.org/obo/DOID_0050153 pulmonary aspergilloma http://purl.obolibrary.org/obo/DOID_850 lung disease An aspergillosis that presents as a clump of tangled mass of Aspergillus fungus fibres, blood clots, and white blood cells, which exists in the cavities of the lungs that develop in an area of previous lung disease or lung scarring. http://purl.obolibrary.org/obo/DOID_0050155 sensory system disease http://purl.obolibrary.org/obo/DOID_863 nervous system disease A nervous system disease which is located in a part of the nervous system responsible for processing sensory information that consists of sensory receptors, neural pathways, and parts of the brain involved in sensory perception. Commonly recognized sensory systems are those for vision, hearing, somatic sensation (touch), taste and olfaction (smell). http://purl.obolibrary.org/obo/DOID_0050156 idiopathic pulmonary fibrosis http://purl.obolibrary.org/obo/DOID_3770 pulmonary fibrosis A pulmonary fibrosis that is characterized by scarring of the lung. http://purl.obolibrary.org/obo/DOID_0050157 cryptogenic organizing pneumonia http://purl.obolibrary.org/obo/DOID_2797 idiopathic interstitial pneumonia An idiopathic interstitial pneumonia characterized by lung inflammation and scarring that obstructs the small airways and air sacs of the lungs (alveoli). A flu-like illness, with a cough, fever, a feeling of illness (malaise), fatigue, and weight loss, heralds the onset in about 50% of people. Frequent presence of crackling sounds (called Velcro crackles) when the doctor listens with a stethoscope. http://purl.obolibrary.org/obo/DOID_0050160 inhalation anthrax http://purl.obolibrary.org/obo/DOID_7427 anthrax disease An anthrax disease that results in infection located in lung lymph nodes brought on by breathing in the spores of the bacteria Bacillus anthracis. The first symptoms of inhalation anthrax are like cold or flu symptoms and can include a sore throat, mild fever and muscle aches. Later symptoms include cough, chest discomfort, shortness of breath, tiredness and muscle aches. http://purl.obolibrary.org/obo/DOID_0050161 lower respiratory tract disease http://purl.obolibrary.org/obo/DOID_1579 respiratory system disease A respiratory system disease which involves the lower respiratory tract. http://purl.obolibrary.org/obo/DOID_0050167 autoimmune polyendocrine syndrome type 1 http://purl.obolibrary.org/obo/DOID_14040 autoimmune polyendocrine syndrome An autoimmune polyendocrine syndrome that is inherited in an autosomal recessive fashion, which is characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs. http://purl.obolibrary.org/obo/DOID_0050168 autoimmune polyendocrine syndrome type 2 http://purl.obolibrary.org/obo/DOID_14040 autoimmune polyendocrine syndrome An autoimmune polyendocrine syndrome that is characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs. It is more heterogeneous and has not been linked to one gene. http://purl.obolibrary.org/obo/DOID_0050169 cutaneous lupus erythematosus http://purl.obolibrary.org/obo/DOID_8857 lupus erythematosus A lupus erythematosus that causes skin lesions on parts of the body that are exposed to sunlight. http://purl.obolibrary.org/obo/DOID_0050175 tick-borne encephalitis http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Tick-borne encephalitis virus, which is transmitted_by Ixodes ticks. The infection has_symptom drowsiness, has_symptom confusion, has_symptom sensory disturbances, and has_symptom paralysis. http://purl.obolibrary.org/obo/DOID_0050177 monogenic disease http://purl.obolibrary.org/obo/DOID_630 genetic disease A genetic disease that is the result of one or more abnormal alleles and may be dominant, semi-dominant, or recessive. http://purl.obolibrary.org/obo/DOID_0050185 erythema multiforme http://purl.obolibrary.org/obo/DOID_37 skin disease A skin disease that is a type of allergic reaction located_in skin, which occurs in response to medications, infections, or illness. http://purl.obolibrary.org/obo/DOID_0050194 Argentine hemorrhagic fever http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Junin virus, which is transmitted_by rodent, Calomys musculinus. The infection has_symptom fever, has_symptom fatigue, has_symptom malaise, has_symptom leukopenia, has_symptom thrombocytopenia, and has_symptom hemorrhagic manifestations. http://purl.obolibrary.org/obo/DOID_0050196 Venezuelan hemorrhagic fever http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Guanarito virus, which is transmitted_by cotton rat, Sigmodon alstoni and transmitted_by cane mouse, Zygodontomys brevicauda. The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom sore throat, has_symptom weakness, has_symptom anorexia, has_symptom nausea, has_symptom vomiting, has_symptom convulsions, has_symptom epistaxis, has_symptom bleeding gums, has_symptom hematemesis, has_symptom melena, and has_symptom menorrhagia. http://purl.obolibrary.org/obo/DOID_0050200 Korean hemorrhagic fever http://purl.obolibrary.org/obo/DOID_11266 Hantavirus hemorrhagic fever with renal syndrome A hemorrhagic fever with renal syndrome that results_in infection located_in kidney, has_material_basis_in Hantaan virus, which is transmitted_by the eurasian field mouse, Apodemus agrarius, or has_material_basis_in Seoul virus, which is transmitted_by norwegian rat, Rattus norvegicus. The infection has_symptom headache, has_symptom back pain, has_symptom abdominal pain, has_symptom fever, has_symptom chills, has_symptom nausea, has_symptom blurred vision, has_symptom flushing of the face, has_symptom redness of the eyes, has_symptom rash, has_symptom low blood pressure, has_symptom acute shock, has_symptom vascular leakage, and has_symptom acute kidney failure, which can cause severe fluid overload. http://purl.obolibrary.org/obo/DOID_0050214 Lambert-Eaton myasthenic syndrome http://purl.obolibrary.org/obo/DOID_439 neuromuscular junction disease A neuromuscular junction disease that is characterized by an abnormality of acetylcholine (ACh) release at the neuromuscular junction which results from an autoimmune attack against voltage-gated calcium channels (VGCC) on the presynaptic motor nerve terminal. http://purl.obolibrary.org/obo/DOID_0050242 primary amebic meningoencephalitis http://purl.obolibrary.org/obo/DOID_331 central nervous system disease A parasitic protozoa infectious disease that involves infection of the central nervous system caused by Naegleria fowleri. The symptoms include headache, nausea, rigidity of the neck muscles, vomiting, delirium, seizures and coma. http://purl.obolibrary.org/obo/DOID_0050246 granulomatous amebic encephalitis http://purl.obolibrary.org/obo/DOID_936 brain disease A parasitic protozoa infectious disease that results in infection of the brain caused by Acanthamoeba or Balamuthia mandrillaris. The symptoms include headaches, altered mental status, and focal neurologic deficit, which progresses over several weeks to death. http://purl.obolibrary.org/obo/DOID_0050256 angiostrongyliasis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that involves parasitic infection of the intestine, central nervous system and eyes by Angiostrongylus cantonensis or Angiostrongylus costaricensis. http://purl.obolibrary.org/obo/DOID_0050266 tungiasis http://purl.obolibrary.org/obo/DOID_4110 parasitic ectoparasitic infectious disease A parasitic ectoparasitic infectious disease that is an inflammatory skin disease caused by the parasitic infestation of the female chigoe flea, Tunga penetrans in animals and humans. The symptoms include skin inflammation, severe pain, itching, and a lesion at the site of infection that is characterized by a black dot at the center of a swollen red lesion, surrounded a white halo. http://purl.obolibrary.org/obo/DOID_0050268 ophthalmomyiasis http://purl.obolibrary.org/obo/DOID_5614 eye disease A myiasis that involves parasitic infestation of Oestrus ovis larvae in the eye causing severe irritation, edema, and pain. http://purl.obolibrary.org/obo/DOID_0050279 conidiobolomycosis http://purl.obolibrary.org/obo/DOID_0050135 subcutaneous mycosis An subcutaneous mycosis that is a chronic inflammatory or granulomatous fungal infection caused by Conidiobolus species, which is restricted to the nasal submucosa and characterized by polyps or palpable restricted subcutaneous masses. Symptoms include nasal obstruction, drainage and sinus pain. Subcutaneous nodules develop in the nasal and perinasal regions. http://purl.obolibrary.org/obo/DOID_0050289 fusariosis http://purl.obolibrary.org/obo/DOID_2473 opportunistic mycosis An opportunistic mycosis that involves localized or hematogenously disseminated fungal infection by Fusarium solani or Fusarium oxysporum. Skin lesions are seen in neutropenic patients, and indolent cellulitis or soft-tissue necrosis occur in immunocompromised patients at the site of trauma. http://purl.obolibrary.org/obo/DOID_0050290 trichosporonosis http://purl.obolibrary.org/obo/DOID_2473 opportunistic mycosis An opportunistic mycosis that results_in disseminated infection, has_material_basis_in Trichosporon and results_in_formation_of nontender erythematous nodules anywhere on the body. http://purl.obolibrary.org/obo/DOID_0050292 primary systemic mycosis http://purl.obolibrary.org/obo/DOID_0050136 systemic mycosis A systemic mycosis that results_in infection located_in human body, has_material_basis_in Fungi, which can overcome the physiological and cellular defences of the normal human host. The primary deep pathogens usually gain access to the host via the respiratory tract. http://purl.obolibrary.org/obo/DOID_0050304 aniseikonia http://purl.obolibrary.org/obo/DOID_9835 refractive error A refractive error that is characterized by the significant difference in perceived sizes of an object between the two eyes. http://purl.obolibrary.org/obo/DOID_0050328 congenital hypothyroidism http://purl.obolibrary.org/obo/DOID_1459 hypothyroidism A hypothyroidism that is present at birth. http://purl.obolibrary.org/obo/DOID_0050331 LADD syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by autosomal dominant inheritance of abnormalities affecting the lacrimal and salivary glands and ducts, ears, teeth and fingers and toes. http://purl.obolibrary.org/obo/DOID_0050332 enlarged vestibular aqueduct http://purl.obolibrary.org/obo/DOID_3426 vestibular disease A vestibular disease that is characterized by progressive hearing loss resulting from congenital enlargement of the vestibular aqueducts. http://purl.obolibrary.org/obo/DOID_0050336 hypophosphatemia http://purl.obolibrary.org/obo/DOID_2485 phosphorus metabolism disease A phosphorus metabolism disease that is characterized by hypophosphatemia and the symptoms of osteomalacia including bone pain, skeletal deformities and osteoarthritis. http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease http://purl.obolibrary.org/obo/DOID_104 bacterial infectious disease A bacterial infectious disease that results_in infection by bacteria as a result of their presence or activity within the normal, healthy host, and their intrinsic virulence is, in part, a necessary consequence of their need to reproduce and spread. http://purl.obolibrary.org/obo/DOID_0050339 commensal bacterial infectious disease http://purl.obolibrary.org/obo/DOID_104 bacterial infectious disease A bacterial infectious disease that results_in infection by bacteria which are part of the normal human flora when one or more of the defense mechanisms designed to restrict them from the usually sterile internal tissues are breached by accident, by intent (surgery), or by an underlying metabolic or an infectious disorder. http://purl.obolibrary.org/obo/DOID_0050340 opportunistic bacterial infectious disease http://purl.obolibrary.org/obo/DOID_104 bacterial infectious disease A bacterial infectious disease that results_in infection by bacteria in individuals whose host defense mechanisms have been compromised. http://purl.obolibrary.org/obo/DOID_0050352 foodborne botulism http://purl.obolibrary.org/obo/DOID_11976 botulism A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), which are transmitted by ingestion of food contaminated with preformed toxins, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F. The infection has symptom blurred vision, has symptom diplopia, has symptom dysarthria, has symptom dysphonia, has symptom dysphagia and has symptom descending muscle paralysis. http://purl.obolibrary.org/obo/DOID_0050353 wound botulism http://purl.obolibrary.org/obo/DOID_11976 botulism A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F), has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F, which are transmitted by contact of spores with the open wounds, which then reproduce in an anaerobic environment to produce toxins. http://purl.obolibrary.org/obo/DOID_0050354 infant botulism http://purl.obolibrary.org/obo/DOID_11976 botulism A botulism that involves intoxication caused by botulinum neurotoxins (BoNTA or B) in infants, has_material_basis_in Clostridium botulinum A or has_material_basis_in Clostridium botulinum B, which are transmitted_by ingestion of bacterial spores, which then grow in the intestine and release toxins. The infection has_symptom constipation, has_symptom lethargy, has_symptom difficulty feeding, has_symptom swallowing, has_symptom ptosis, has_symptom loss of head control, and has_symptom muscle weakness. http://purl.obolibrary.org/obo/DOID_0050398 Carrion's disease http://purl.obolibrary.org/obo/DOID_11102 bartonellosis A bartonellosis that results_in infection located_in endothelial cells or located_in red blood cells, has_material_basis_in Bartonella bacilliformis, which is transmitted_by sandflies of genus Lutzomyia. The infection has acute and chronic phases. The acute phase is characterized by severe hemolytic anemia and transient immunosuppression. The chronic phase is characterized by verruga peruana lesions which may ulcerate and bleed. http://purl.obolibrary.org/obo/DOID_0050424 familial adenomatous polyposis http://purl.obolibrary.org/obo/DOID_5295 intestinal disease An intestinal disease that has_material_basis_in mutations in the APC gene and involves formation of numerous polyps in the epithelium of the large intestine which are initially benign and later transform into colon cancer. http://purl.obolibrary.org/obo/DOID_0050426 Stevens-Johnson syndrome http://purl.obolibrary.org/obo/DOID_37 skin disease A skin disease that is characterized by ulceration of less than 10 percent of the surface area of the body. The disease is often precipitated by the use of medications, such as antibiotics or antiepileptics, or onset of infection. http://purl.obolibrary.org/obo/DOID_0050427 xeroderma pigmentosum http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by a deficiency in the ability to repair ultraviolet damage that has_material_basis_in autosomal recessive inheritance of DNA repair. http://purl.obolibrary.org/obo/DOID_0050428 nonepidermolytic palmoplantar keratoderma http://purl.obolibrary.org/obo/DOID_3390 palmoplantar keratosis A palmoplantar keratosis characterized by a well-demarcated, symmetric keratoderma located_in palms and located_in soles. http://purl.obolibrary.org/obo/DOID_0050429 Hailey-Hailey disease http://purl.obolibrary.org/obo/DOID_9182 pemphigus A pemphigus that is characterized by recurring blistering most commonly occurring in the folds of the skin and has_material_basis_in mutations in the ATP2C1 gene that result in loss of adhesion within the skin. http://purl.obolibrary.org/obo/DOID_0050430 multiple endocrine neoplasia type 2A http://purl.obolibrary.org/obo/DOID_0050736 autosomal dominant disease A multiple endocrine neoplasia characterized by medullary carcinoma of the thyroid, pheochromocytoma, hyperparathyroidism, and occasionally cutaneous lichen amyloidosis. http://purl.obolibrary.org/obo/DOID_0050431 arrhythmogenic right ventricular cardiomyopathy http://purl.obolibrary.org/obo/DOID_0060036 intrinsic cardiomyopathy An intrinsic cardiomyopathy that is characterized by hypokinetic areas involving the free wall of the right ventricle, with fibrofatty replacement of the right ventricular myocardium, with associated arrhythmias originating in the right ventricle. http://purl.obolibrary.org/obo/DOID_0050432 Asperger syndrome http://purl.obolibrary.org/obo/DOID_0060041 autism spectrum disorder An autism spectrum disorder that is characterized by significant difficulties in social interaction, along with restricted and repetitive patterns of behavior and interests. It differs from other autism spectrum disorders by its relative preservation of linguistic and cognitive development. http://purl.obolibrary.org/obo/DOID_0050433 fatal familial insomnia http://purl.obolibrary.org/obo/DOID_649 prion disease A prion disease that is characterized by insomnia, hallucinations, dementia and death, located_in the brain. http://purl.obolibrary.org/obo/DOID_0050436 mulibrey nanism http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by global growth retardation of the muscle, liver, brain and eyes as well as constrictive pericarditis and has_material_basis_in mutations in the TRIM37 gene. http://purl.obolibrary.org/obo/DOID_0050437 Danon disease http://purl.obolibrary.org/obo/DOID_3211 lysosomal storage disease A lysosomal storage disease that is characterized by cardiomyopathy, skeletal myopathy and intellectual disability and has_material_basis_in mutations in the LAMP2 gene. http://purl.obolibrary.org/obo/DOID_0050438 Frasier syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by gonadal dysgenesis, streak gonads, progressive focal segmental glomerulonephropathy and the development of urogenital cancers that is the result of mutation in the WT1 gene. http://purl.obolibrary.org/obo/DOID_0050439 Usher syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by a combination of hearing loss and visual impairment. http://purl.obolibrary.org/obo/DOID_0050441 mucosulfatidosis http://purl.obolibrary.org/obo/DOID_1927 sphingolipidosis A sphingolipidosis that is characterized by leukodystrophy, ichthyosis, skeletal abnormalities and shortened life expectancy and has_material_basis_in mutation in the SUMF1 gene that results in deficiency in multiple sulfatase enzymes. http://purl.obolibrary.org/obo/DOID_0050444 infantile Refsum disease http://purl.obolibrary.org/obo/DOID_906 peroxisomal disease A peroxisomal disease that is characterized by neurological impairment, intellectual disability, hepatosplenomegaly and ichthyosis and results from the accumulation of very long chain fatty acids and phytanic acid, secondary to mutation in the PEX genes. http://purl.obolibrary.org/obo/DOID_0050445 X-linked dominant hypophosphatemic rickets http://purl.obolibrary.org/obo/DOID_10609 rickets A rickets has_material_basis in X-linked mutations in the PHEX gene that lead to increased circulating levels of FGF-23, a phosphate-regulating hormone (phosphatonin), that leads to reduced renal phosphate reabsorption and consequently abnormal bone mineralization. http://purl.obolibrary.org/obo/DOID_0050448 hereditary mucosal leukokeratosis http://purl.obolibrary.org/obo/DOID_37 skin disease A skin disease characterized by a defect in the normal process of keratinization of the mucosa. http://purl.obolibrary.org/obo/DOID_0050449 pachyonychia congenita http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by hypertrophic nails and hyperkeratosis of the hands and feet and has_material_basis in gene mutations that result in changes in keratin. http://purl.obolibrary.org/obo/DOID_0050450 Gitelman syndrome http://purl.obolibrary.org/obo/DOID_447 renal tubular transport disease A renal tubular transport disease that is has_material_basis_in mutations in genes that produce proteins involved in the kidneys' reabsorption of salt (sodium chloride or NaCl) from urine back into the bloodstream, thus impairing the kidneys' ability to reabsorb salt, leading to the loss of excess salt in the urine (salt wasting). http://purl.obolibrary.org/obo/DOID_0050451 Brugada syndrome http://purl.obolibrary.org/obo/DOID_10273 heart conduction disease A heart conduction disease that is characterized by abnormal electrocardiogram (ECG) findings and an increased risk of sudden cardiac death. http://purl.obolibrary.org/obo/DOID_0050452 mevalonic aciduria http://purl.obolibrary.org/obo/DOID_906 peroxisomal disease A peroxisomal disease that is characterized by cortical atrophy, microcephaly, dysmorphic facies, muscular hypotonia and intellectual disability and has_material_basis_in mutation in the MVK gene that results in deficiency of mevalonate kinase and impaired cholesterol. biosynthesis. http://purl.obolibrary.org/obo/DOID_0050453 lissencephaly http://purl.obolibrary.org/obo/DOID_2490 congenital nervous system abnormality A congenital nervous system abnormality characterized by the absence of folds in the cerebral cortex and caused_by defective neuronal migration during the 12th to 24th weeks of gestation. http://purl.obolibrary.org/obo/DOID_0050454 periventricular nodular heterotopia http://purl.obolibrary.org/obo/DOID_2490 congenital nervous system abnormality A congenital nervous system abnormality characterized by non proper migration of neurons during the early development of the fetal brain. http://purl.obolibrary.org/obo/DOID_0050456 Buruli ulcer disease http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that results_in infection located_in skin or located_in subcutaneous tissue, has_material_basis_in Mycobacterium ulcerans, which could be transmitted_by insects. The bacterium produces a toxin, named mycolactone, which causes subcutaneous fat necrosis and inhibits an immune response. The infection has_symptom nodule, which is a painless, mobile swelling in the skin. http://purl.obolibrary.org/obo/DOID_0050457 Sertoli cell-only syndrome http://purl.obolibrary.org/obo/DOID_12336 male infertility A male infertility disease characterized by male sterility, has_material_basis_in azospermia without abnormal sexual development. http://purl.obolibrary.org/obo/DOID_0050458 juvenile myelomonocytic leukemia http://purl.obolibrary.org/obo/DOID_4972 myelodysplastic/myeloproliferative neoplasm A myelodysplastic/myeloproliferative neoplasm that is characterized by the uncontrolled growth of monocytes. http://purl.obolibrary.org/obo/DOID_0050459 hyperphosphatemia http://purl.obolibrary.org/obo/DOID_2485 phosphorus metabolism disease A phosphorus metabolism disease characterized by hyperphosphatemia and abnormal deposits of phosphate and calcium in joints and soft tissues, results from abnomral phosphorus metabolism and has_material_basis_in mutations in the FGF23, GALNT3 or KL gene. http://purl.obolibrary.org/obo/DOID_0050460 Wolf-Hirschhorn syndrome http://purl.obolibrary.org/obo/DOID_0060388 chromosomal deletion syndrome A chromosomal deletion syndrome that is characterized by distinct craniofacial features, hypotonia and intellectual disability and has_material_basis_in a microdeletion of the short arm of chromosome 4. http://purl.obolibrary.org/obo/DOID_0050461 aspartylglucosaminuria http://purl.obolibrary.org/obo/DOID_630 genetic disease A lysosomal storage disease that is characterized by delayed speech at 2-3 years of age, has_material_basis_in mutations in the AGA gene that result in the absence or shortage of the aspartylglucosaminidase enzyme in lysosomes, preventing the normal breakdown of glycoproteins. http://purl.obolibrary.org/obo/DOID_0050462 Antley-Bixler syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized at birth or prenatally by malformations and deformities affecting the majority of the skeleton and other areas of the body with autosomal recessive inheritance of the FGFR2 gene. http://purl.obolibrary.org/obo/DOID_0050463 campomelic dysplasia http://purl.obolibrary.org/obo/DOID_2256 osteochondrodysplasia An osteochondrodysplasia that has_material_basis_in a mutation in chromosome 17 which results_in bowing in the located_in tibia or located_in femur. http://purl.obolibrary.org/obo/DOID_0050464 Farber lipogranulomatosis http://purl.obolibrary.org/obo/DOID_9455 lipid storage disease A lipid storage disease that is characterized by abnormalities in swallowing, cognition, joint function, and central nervous system due to a deficiency in the enzyme ceramidase that results in sphingolipids deposition. http://purl.obolibrary.org/obo/DOID_0050465 Muir-Torre syndrome http://purl.obolibrary.org/obo/DOID_3883 Lynch syndrome A Lynch syndrome that is characterized by a propensity to develop cancers of the gastrointestinal tract, genitourinary tract, and skin that has_material_basis_in mutations in DNA mismatch repair genes. http://purl.obolibrary.org/obo/DOID_0050466 Loeys-Dietz syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by increased risk of aortic aneurysm and dissection, elongated limbs, hypertelorism, bifid uvula and easy skin bruising due to mutations in TGFB3 that results in connective tissue defects. http://purl.obolibrary.org/obo/DOID_0050467 erythrokeratodermia variabilis http://purl.obolibrary.org/obo/DOID_37 skin disease A skin disease that is characterized by areas of sharply demarcated, brown hyperkeratosis and has_material_basis_in mutations in genes encoding for connexin channels proteins in the epidermis. http://purl.obolibrary.org/obo/DOID_0050468 yellow nail syndrome http://purl.obolibrary.org/obo/DOID_4123 nail disease A syndrome that is characterized by an accumulation of protein-rich fluid (lymph) in the soft layers of tissue under the skin resulting in pleural effusions, lymphedema (due to lymphatic hypoplasia) and yellow dystrophic nails hat lack a cuticle, grow slowly, and are loose or detached. http://purl.obolibrary.org/obo/DOID_0050469 Costello syndrome http://purl.obolibrary.org/obo/DOID_0080690 RASopathy A RASopathy characterized by craniofacial dysmorphology, cardiac defects, mild mental retardation, and high birth weight followed by a failure to thrive and developmental delays. http://purl.obolibrary.org/obo/DOID_0050470 Donohue syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by protuberant and low-set ears, flaring nostrils, thick lips, enlarged secondary sex organs and overwhelming insulin resistance and has_material_basis_in mutation within the INSR gene causing abnormalities in the insulin receptor. http://purl.obolibrary.org/obo/DOID_0050471 Carney complex http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by myxomas, spotty pigmentation of the skin and endocrine overactivity. http://purl.obolibrary.org/obo/DOID_0050472 monilethrix http://purl.obolibrary.org/obo/DOID_0050736 autosomal dominant disease A hair disease that is characterized by short, easily broken hair that results in alopecia and has_material_basis_in mutations in genes for type II hair cortex keratins. http://purl.obolibrary.org/obo/DOID_0050473 Alstrom syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by multiorgan dysfunction. The key features are childhood obesity, blindness due to congenital retinal dystrophy, and sensorineural hearing loss with autosomal recessive inheritance and has_material_basis_in mutations in the ALMS1 gene. http://purl.obolibrary.org/obo/DOID_0050474 Netherton syndrome http://purl.obolibrary.org/obo/DOID_37 skin disease A skin disease that is characterized by chronic skin inflammation, trichorrhexis invaginata, atopic dermatitis and has_material_basis_in mutations in the SPINK5 gene resulting in reduced capacity to inhibit serine proteases expressed in the skin. http://purl.obolibrary.org/obo/DOID_0050475 Weill-Marchesani syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by short stature, bachycephaly and other facial abnormalities, brachydactyly, joint stiffness and distinctive ocular abnormalities. http://purl.obolibrary.org/obo/DOID_0050476 Barth syndrome http://purl.obolibrary.org/obo/DOID_3146 lipid metabolism disorder A lipid metabolism disorder that has_material_basis_in X-linked inheritance of the tafazzin gene and is characterized by decreased production of an enzyme required to produce cardiolipin. http://purl.obolibrary.org/obo/DOID_0050477 Liddle syndrome http://purl.obolibrary.org/obo/DOID_447 renal tubular transport disease A renal tubular transport disease that is characterized by hypertension and hypokalemia caused by dysregulation of epithelial sodium channels causing over expression of the channel. http://purl.obolibrary.org/obo/DOID_0050481 endemic typhus http://purl.obolibrary.org/obo/DOID_11256 typhus A typhus that has_material_basis_in Rickettsia typhi or has_material_basis_in Rickettsia felis, which are transmitted by fleas (Xenopsylla cheopis). The infection has symptom headache, has symptom fever, has symptom chills, has symptom myalgia, has symptom nausea, has symptom vomiting, has symptom cough and has symptom rash. http://purl.obolibrary.org/obo/DOID_0050485 sennetsu fever http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that results_in infection, has_material_basis_in Neorickettsia sennetsu, which is transmitted_by ingestion of raw or under-cooked gray mullet fish infected with the trematodes. The infection has_symptom fever, has_symptom malaise, has_symptom anorexia, has_symptom lymphadenopathy, has_symptom hepatosplenomegaly, has_symptom fatigue, has_symptom chills, has_symptom headache, has_symptom backache and has_symptom myalgia. http://purl.obolibrary.org/obo/DOID_0050486 exanthem http://purl.obolibrary.org/obo/DOID_37 skin disease A skin disease that is characterized by a rash that results from a variety of causes including bacteria, viruses, toxins, drugs and autoimmune disorders. http://purl.obolibrary.org/obo/DOID_0050495 exanthema subitum http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in infection in infants and children, located_in skin, has_material_basis_in Human herpesvirus 6 or has_material_basis_in Human herpesvirus 7 and has_symptom sudden high fever, and has_symptom red rash that occurs first on the trunk then spreading to legs and neck. http://purl.obolibrary.org/obo/DOID_0050523 adult T-cell leukemia http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A T-cell leukemia that results_in abnormal increase of lymphocytes, derives_from T-cells, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, transmitted_by contaminated needles used by intravenous-drug users, and transmitted_by breast feeding. The infection results_in_formation_of skin lesions. http://purl.obolibrary.org/obo/DOID_0050524 maturity-onset diabetes of the young http://purl.obolibrary.org/obo/DOID_9351 diabetes mellitus A diabetes mellitus that has_material_basis_in autosomal dominant inheritance of mutations in the MODY genes impacting beta-cell function, typically occurring before 25 years of age and caused by primary insulin secretion defects. http://purl.obolibrary.org/obo/DOID_0050528 nonphotosensitive trichothiodystrophy 4 http://purl.obolibrary.org/obo/DOID_0111867 nonphotosensitive trichothiodystrophy A syndrome that is characterized by brittle hair, short stature, decreased fertility and cognitive impairment without photosensitivity has_material_basis_in mutations in the TTDN1 gene. http://purl.obolibrary.org/obo/DOID_0050529 adult spinal muscular atrophy http://purl.obolibrary.org/obo/DOID_12377 spinal muscular atrophy A spinal muscular atrophy that is characterized by progressive muscular weakness and motor disability that typically presents in the third decade of life and has_material_basis_in mutations in the SMN1 or SMN2 genes that are required for the survival of motor neurons. http://purl.obolibrary.org/obo/DOID_0050534 congenital stationary night blindness http://purl.obolibrary.org/obo/DOID_0080015 physical disorder A hereditary night blindness that is characterized by hemeralopia with a moderate loss of visual acuity and caused by defective photoreceptor-to-bipolar cell signaling with common ERG findings of reduced or absent b-waves and generally normal a-waves. http://purl.obolibrary.org/obo/DOID_0050535 exudative vitreoretinopathy http://purl.obolibrary.org/obo/DOID_2462 retinal vascular disease A retinal vascular disease characterized by the prevention of blood vessel formation at the edges of the retina and the hemorrhage of the blood vessels in the retina. http://purl.obolibrary.org/obo/DOID_0050537 posterior polar cataract http://purl.obolibrary.org/obo/DOID_83 cataract A cataract that is characterized by a distinctive discoid lens opacity situated posteriorly and adjacent to the posterior capsule. http://purl.obolibrary.org/obo/DOID_0050538 Charcot-Marie-Tooth disease type 1 http://purl.obolibrary.org/obo/DOID_10595 Charcot-Marie-Tooth disease A Charcot-Marie-Tooth disease characterized by demyelination of the peripheral nerve axons. http://purl.obolibrary.org/obo/DOID_0050540 Charcot-Marie-Tooth disease type 3 http://purl.obolibrary.org/obo/DOID_10595 Charcot-Marie-Tooth disease A Charcot-Marie-Tooth disease that is characterized by motor and sensory peripheral neuropathies caused by demyelination. http://purl.obolibrary.org/obo/DOID_0050544 hypermethioninemia http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder An amino acid metabolic disorder that involves an excess of the amino acid methionine, in the blood. This condition can occur when methionine is not broken down properly in the body. http://purl.obolibrary.org/obo/DOID_0050545 visceral heterotaxy http://purl.obolibrary.org/obo/DOID_0080015 physical disorder A physical disorder characterized by the abnormal distribution of the major visceral organs within the chest and abdomen. http://purl.obolibrary.org/obo/DOID_0050546 congenital adrenal insufficiency http://purl.obolibrary.org/obo/DOID_9553 adrenal gland disease An adrenal gland disease that is characterized by cortisol deficiency, hypoaldosteronism and excessive or insufficient sex hormones, has_material_basis_in the mutation in the gene for 21-hydroxylase, 11beta-hydroxylase, 3beta-hydroxysteroid, 17alpha-hydroxylase or 20,22-desmolase. http://purl.obolibrary.org/obo/DOID_0050547 familial medullary thyroid carcinoma http://purl.obolibrary.org/obo/DOID_3973 thyroid gland medullary carcinoma A thyroid gland medullary carcinoma that has_material_basis_in autosomal dominant inheritance. http://purl.obolibrary.org/obo/DOID_0050548 hereditary sensory neuropathy http://purl.obolibrary.org/obo/DOID_870 neuropathy A neuropathy characterized by congenital insensitivity to pain resulting in ulceration to the fingers, tongue, lips, and other distal appendages. http://purl.obolibrary.org/obo/DOID_0050553 JMP syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by childhood onset of joint stiffness and severe contractures of the hands and feet, erythematous skin lesions with subsequent development of severe lipodystrophy that has_material_basis_in homozygous or compound heterozygous mutation in PSMB8 on chromosome 6p21.32. http://purl.obolibrary.org/obo/DOID_0050554 X-linked sideroblastic anemia with ataxia http://purl.obolibrary.org/obo/DOID_8955 sideroblastic anemia A sideroblastic anemia that is characterized by decreased production of hemoglobin and ataxia and has_material_basis_in the mutation in the ABCB7 gene. http://purl.obolibrary.org/obo/DOID_0050557 congenital muscular dystrophy http://purl.obolibrary.org/obo/DOID_9884 muscular dystrophy A muscular dystrophy that is characterized by diminished muscle tone (hypotonia), progressive muscle weakness and degeneration (atrophy), abnormally fixed joints, spinal rigidity, and delays in reaching motor milestones such as sitting or standing unassisted. http://purl.obolibrary.org/obo/DOID_0050558 Ullrich congenital muscular dystrophy http://purl.obolibrary.org/obo/DOID_0050737 autosomal recessive disease A congenital muscular dystrophy that is characterized by muscle weakness and respiratory depression and has_material_basis_in mutation in the COL6A1, COL6A2 and COL6A3 that produce components of type VI collagen. http://purl.obolibrary.org/obo/DOID_0050559 Fukuyama congenital muscular dystrophy http://purl.obolibrary.org/obo/DOID_0111229 congenital muscular dystrophy-dystroglycanopathy type A A congenital muscular dystrophy-dystroglycanopathy type A that is characterized by muscle weakness, failure to thrive, severe intellectual and developmental disability, impaired vision and cardiac abnormalities and has_material_basis_in mutation in the FKTN gene that produces the fukutin protein. http://purl.obolibrary.org/obo/DOID_0050560 Walker-Warburg syndrome http://purl.obolibrary.org/obo/DOID_0050737 autosomal recessive disease A congenital muscular dystrophy that is characterized by hypotonia, seizures, severe intellectual and developmental disability, eye abnormalities and early death and has_material_basis_in mutations in multiple genes including POMT1, POMT2, ISPD, FKTN, FKRP, and LARGE1. http://purl.obolibrary.org/obo/DOID_0050561 Lennox-Gastaut syndrome http://purl.obolibrary.org/obo/DOID_0050704 childhood electroclinical syndrome A childhood electroclinical syndrome that is characterized by frequent seizures and intellectual disability that present in early childhood. http://purl.obolibrary.org/obo/DOID_0050563 nonsyndromic deafness http://purl.obolibrary.org/obo/DOID_2742 auditory system disease An auditory system disease that is associated with permanent hearing loss caused by damage to structures in the inner ear and/or the middle ear, which is not associated with other signs and symptoms. http://purl.obolibrary.org/obo/DOID_0050566 X-linked nonsyndromic deafness http://purl.obolibrary.org/obo/DOID_0050735 X-linked monogenic disease A nonsyndromic deafness characterized by an X-linked inheritance mode. http://purl.obolibrary.org/obo/DOID_0050567 orofacial cleft http://purl.obolibrary.org/obo/DOID_225 syndrome A physical disorder that is characterized by cleft lip and/or cleft palate that result in feeding, speech and hearing problems caused by failures during development. http://purl.obolibrary.org/obo/DOID_0050568 spondylocostal dysostosis http://purl.obolibrary.org/obo/DOID_1934 dysostosis A dysostosis that results_in abnormal development located_in vertebrae or located_in ribs. The bones of the spine do not develop properly, which causes them to be misshapen and abnormally joined together. http://purl.obolibrary.org/obo/DOID_0050569 Seckel syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by intrauterine growth retardation and postnatal dwarfism with microcephaly and intellectual disability. http://purl.obolibrary.org/obo/DOID_0050572 cone-rod dystrophy http://purl.obolibrary.org/obo/DOID_8466 retinal degeneration A retinal degeneration that characterized by progressive deterioration of the cone and rod photoreceptor cells. http://purl.obolibrary.org/obo/DOID_0050573 2-hydroxyglutaric aciduria http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder An amino acid metabolic disorder that is an autosomal recessive neurometabolic disorder characterized by the significant elevation of urinary levels of hydroxyglutaric acid causing progressive brain damage. http://purl.obolibrary.org/obo/DOID_0050574 L-2-hydroxyglutaric aciduria http://purl.obolibrary.org/obo/DOID_2786 cerebellar disease An 2-hydroxyglutaric aciduria that involves damage to cerebellum affecting movement coordination resulting in problems with balance and muscle coordination (ataxia). http://purl.obolibrary.org/obo/DOID_0050575 D-2-hydroxyglutaric aciduria http://purl.obolibrary.org/obo/DOID_0050573 2-hydroxyglutaric aciduria An 2-hydroxyglutaric aciduria that involves developmental delay, seizures, weak muscle tone (hypotonia), and abnormalities in the largest part of the brain (the cerebrum), which controls many important functions such as muscle movement, speech, vision, thinking, emotion, and memory. http://purl.obolibrary.org/obo/DOID_0050577 cranioectodermal dysplasia http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by characterized by sagittal craniosynostosis and facial, ectodermal, and skeletal anomalies. http://purl.obolibrary.org/obo/DOID_0050578 occult macular dystrophy http://purl.obolibrary.org/obo/DOID_4448 macular degeneration A macular degeneration that is characterized by a central cone dysfunction leading to a loss of vision with a normal fundus and normal fluorescein angiography findings. http://purl.obolibrary.org/obo/DOID_0050581 brachydactyly http://purl.obolibrary.org/obo/DOID_1934 dysostosis A dysostosis characterized by short fingers and toes. http://purl.obolibrary.org/obo/DOID_0050587 trichotillomania http://purl.obolibrary.org/obo/DOID_10937 impulse control disorder An impulse control disorder that involves the uncontrollable plucking of ones hair. http://purl.obolibrary.org/obo/DOID_0050588 muscular dystrophy-dystroglycanopathy http://purl.obolibrary.org/obo/DOID_0050737 autosomal recessive disease A congenital muscular dystrophy characterized by muscle weakness, cognitive impairment and brain abnormalities and has_material_basis_in mutation to the POMT1 gene that encodes O-mannosyltransferase. http://purl.obolibrary.org/obo/DOID_0050589 inflammatory bowel disease http://purl.obolibrary.org/obo/DOID_5295 intestinal disease An intestinal disease characterized by inflammation located in all parts of digestive tract. http://purl.obolibrary.org/obo/DOID_0050590 severe congenital neutropenia http://purl.obolibrary.org/obo/DOID_1227 neutropenia A neutropenia characterized by a maturation arrest of granulopoiesis at the level or promyelocytes and early onset of severe bacterial infections. http://purl.obolibrary.org/obo/DOID_0050591 tooth agenesis http://purl.obolibrary.org/obo/DOID_1091 tooth disease A tooth disease characterized by failure to develop on or more missing teeth. http://purl.obolibrary.org/obo/DOID_0050592 asphyxiating thoracic dystrophy http://purl.obolibrary.org/obo/DOID_0080006 bone development disease A bone development disease characterized by skeletal abnormalities and resulting in difficulty in breathing caused by mutations that result in ciliopathy. http://purl.obolibrary.org/obo/DOID_0050596 taeniasis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that has_material_basis_in Taenia solium or has_material_basis_in Taenia saginata, which are transmitted by ingestion of undercooked contaminated meat. http://purl.obolibrary.org/obo/DOID_0050597 intestinal schistosomiasis http://purl.obolibrary.org/obo/DOID_5295 intestinal disease A schistosomiasis that involves parasitic infection of the intestine caused by Schistosoma mansoni, Schistosoma intercalatum or Schistosomiasis japonicum. The symptoms include fever, cough, abdominal pain, diarrhea, hepatosplenomegaly, colonic polyposis with bloody diarrhea and eosinophilia. http://purl.obolibrary.org/obo/DOID_0050598 extrapulmonary tuberculosis http://purl.obolibrary.org/obo/DOID_399 tuberculosis A tuberculosis that occurs at body sites other than the lung. http://purl.obolibrary.org/obo/DOID_0050599 abdominal tuberculosis http://purl.obolibrary.org/obo/DOID_0050598 extrapulmonary tuberculosis An extrapulmonary tuberculosis that is located_in gastrointestinal tract, located_in peritoneum, located_in omentum, located_in mesentery, located_in liver, located_in spleen or located_in pancreas. http://purl.obolibrary.org/obo/DOID_0050600 ABCD syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by albinism, black lock, cell migration disorder of the neurocytes of the gut and sensorineural deafness and has_material_basis_in a mutation in the endothelin B receptor gene (EDNRB). http://purl.obolibrary.org/obo/DOID_0050601 ADULT syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by light pigmentation with excessive freckling, sparse hair involving the scalp and axilla, lacrimal duct stenosis or atresia, onychodysplasia, hypodontia or early loss of permanent teeth, athelia or hypoplastic nipples, and breast hypoplasia, has_material_basis_in a mutation in TP63. http://purl.obolibrary.org/obo/DOID_0050602 triple-A syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by achalasia, adrenal insufficiency and alacrima and has_material_basis_in mutations in the AAAS gene that encodes ALADIN within the nuclear envelope and results in dysfunction of the autonomic nervous system. http://purl.obolibrary.org/obo/DOID_0050603 acheiropody http://purl.obolibrary.org/obo/DOID_2256 osteochondrodysplasia An osteochondrodysplasia characterized by a lack of formation of the distal extremities has_material_basis_in mutation in the LMBR1 gene. http://purl.obolibrary.org/obo/DOID_0050605 acrodermatitis enteropathica http://purl.obolibrary.org/obo/DOID_896 metal metabolism disorder A metal metabolism disorder characterized by dermatitis around bodily openings and the tips of fingers and toes, alopecia and diarrhea and has_material_basis_in mutation in the SLC39A4 gene that encodes a zinc uptake protein and results in zinc deficiency. http://purl.obolibrary.org/obo/DOID_0050606 acrokeratosis verruciformis http://purl.obolibrary.org/obo/DOID_161 keratosis A keratosis that has_material_basis_in mutations in the ATP2A2 gene. http://purl.obolibrary.org/obo/DOID_0050615 respiratory system cancer http://purl.obolibrary.org/obo/DOID_1579 respiratory system disease An organ system cancer located_in the respiratory system that is characterized by uncontrolled cellular proliferation in the respiratory tract. http://purl.obolibrary.org/obo/DOID_0050619 paranasal sinus cancer http://purl.obolibrary.org/obo/DOID_1352 paranasal sinus disease A respiratory system cancer that is located_in the paranasal sinuses. http://purl.obolibrary.org/obo/DOID_0050621 respiratory system benign neoplasm http://purl.obolibrary.org/obo/DOID_1579 respiratory system disease An organ system benign neoplasm that is located in the respiratory system which extends from the nasal sinuses to the diaphragm. http://purl.obolibrary.org/obo/DOID_0050622 reproductive organ benign neoplasm http://purl.obolibrary.org/obo/DOID_15 reproductive system disease An organ system benign neoplasm that is located_in reproductive system organs. http://purl.obolibrary.org/obo/DOID_0050623 bladder benign neoplasm http://purl.obolibrary.org/obo/DOID_731 urinary system benign neoplasm A urinary system benign neoplasm located_in the bladder including papillomas, leiomyomas, fibromas, hemangiomas, neurofibromas and lipomas. http://purl.obolibrary.org/obo/DOID_0050624 gastrointestinal system benign neoplasm http://purl.obolibrary.org/obo/DOID_77 gastrointestinal system disease An organ system benign neoplasm located_in gastrointestinal tract organs. http://purl.obolibrary.org/obo/DOID_0050625 biliary tract benign neoplasm http://purl.obolibrary.org/obo/DOID_9741 biliary tract disease A hepatobiliary benign neoplasm located_in the biliary tract. http://purl.obolibrary.org/obo/DOID_0050629 Aicardi-Goutieres syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is a genetically heterogeneous encephalopathy characterized in its most severe form by cerebral atrophy, leukodystrophy, intracranial calcifications, chronic cerebrospinal fluid lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infections. http://purl.obolibrary.org/obo/DOID_0050630 Aland Island eye disease http://purl.obolibrary.org/obo/DOID_5614 eye disease An eye disease characterized by fundus hypopigmentation, decreased visual acuity, nystagmus, astigmatism, myopia and defective darkness adaptation and has_material_basis_in mutation in the CACNA1F gene. http://purl.obolibrary.org/obo/DOID_0050631 Allan-Herndon-Dudley syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that has_material_basis_in mutation at is in the gene encoding the monocarboxylate transporter-8 which alters the structure and function of the SLC16A2 protein which is then unable to transport the thyroid triiodothyronine (T3) hormone into nerve cells of the developing brain affecting normal brain development resulting in intellectual disability and problems with movement. http://purl.obolibrary.org/obo/DOID_0050632 oculocutaneous albinism http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by abnormal pigmentation of the skin, hair and eyes. http://purl.obolibrary.org/obo/DOID_0050633 ocular albinism http://purl.obolibrary.org/obo/DOID_5614 eye disease An eye disease that is characterized by reduced pigmentation of the iris and the resulting impairment of visual acuity without significantly affecting the color of skin or hair and has_material_basis in mutation in the GPR143 gene that encodes segments of the melanosomes that stores melanin. http://purl.obolibrary.org/obo/DOID_0050639 primary cutaneous amyloidosis http://purl.obolibrary.org/obo/DOID_9120 amyloidosis An amyloidosis characterized by pruritus, skin scratching and by deposits of amyloid in the dermis. http://purl.obolibrary.org/obo/DOID_0050644 arterial calcification of infancy http://purl.obolibrary.org/obo/DOID_0050828 artery disease A vascular disease that is characterized by generalized calcification of the arterial internal elastic lamina, leading to rupture of the lamina and occlusive changes in the tunica intima with stenosis and decreased elasticity of the vessel wall. http://purl.obolibrary.org/obo/DOID_0050645 arterial tortuosity syndrome http://purl.obolibrary.org/obo/DOID_65 connective tissue disease A connective tissue disease that is characterized by elongation and generalized tortuosity of the major arteries including the aorta. http://purl.obolibrary.org/obo/DOID_0050646 distal arthrogryposis http://purl.obolibrary.org/obo/DOID_66 muscle tissue disease A muscle tissue disease characterized by congenital joint contractures of hand and feet. http://purl.obolibrary.org/obo/DOID_0050647 Arts syndrome http://purl.obolibrary.org/obo/DOID_0060309 syndromic X-linked intellectual disability An X-linked disease that is characterized by profound congenital sensorineural hearing impairment, early-onset hypotonia, delayed motor development, mild to moderate intellectual disability, ataxia, and increased risk of infection and has_material_basis_in mutations of the PRPS1 gene. http://purl.obolibrary.org/obo/DOID_0050648 atelosteogenesis http://purl.obolibrary.org/obo/DOID_2256 osteochondrodysplasia An osteochondrodysplasia that is characterized by specific patterns of aplasia/hypoplasia of humeri, femora, spine in newborns. http://purl.obolibrary.org/obo/DOID_0050649 atransferrinemia http://purl.obolibrary.org/obo/DOID_896 metal metabolism disorder A metal metabolism disorder that is characterized by transferrin deficiency, microcytic anemia, and iron loading, and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the structural gene for transferrin on chromosome 3q22. http://purl.obolibrary.org/obo/DOID_0050650 familial atrial fibrillation http://purl.obolibrary.org/obo/DOID_0060224 atrial fibrillation An atrial fibrillation that has_material_basis_in autosomal dominant inheritance of the familial atrial fibrillation (ATFB) genes. http://purl.obolibrary.org/obo/DOID_0050651 atrioventricular septal defect http://purl.obolibrary.org/obo/DOID_1681 heart septal defect A congenital heart septal defect characterized by an abnormal or inadequate fusion of the superior and inferior endocardial cushions with the mid portion of the atrial septum and the muscular portion of the ventricular septum, thus allowing extra blood to circulate the lungs. http://purl.obolibrary.org/obo/DOID_0050654 Baller-Gerold syndrome http://purl.obolibrary.org/obo/DOID_11971 synostosis A synostosis characterized by coronal craniosynostosis, short stature, and aplasia or hypoplasia of the radial bone. http://purl.obolibrary.org/obo/DOID_0050655 Bamforth-Lazarus syndrome http://purl.obolibrary.org/obo/DOID_1459 hypothyroidism A hypothyroidism that is characterized by thyroid dysgenesis, cleft palate, spiky hair and bifid epiglottis, has_material_basis_in homozygous mutation in the FKHL15 gene on chromosome 9q22. http://purl.obolibrary.org/obo/DOID_0050656 pseudo-TORCH syndrome 1 http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by congenital microcephaly, intracranial calcifications, severe developmental delay, simplified gyration and polymicrogyria that has_material_basis_in homozygous or compound heterozygous mutation in OCLN on chromosome 5q13.2. http://purl.obolibrary.org/obo/DOID_0050657 Bannayan-Riley-Ruvalcaba syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by macrocephaly, multiple noncancerous tumors and hamartomas, and dark freckles on the penis, and has_material_basis_in heterozygous germline mutation in the PTEN gene on chromosome 10q23. http://purl.obolibrary.org/obo/DOID_0050658 Bart-Pumphrey syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by leukonychia, wart-like skin growths, palmoplantar keratoderma and hearing loss, has_material_basis_in heterozygous mutation in the GJB2 gene on chromosome 13q12. http://purl.obolibrary.org/obo/DOID_0050659 biotin-responsive basal ganglia disease http://purl.obolibrary.org/obo/DOID_679 basal ganglia disease A basal ganglia disease that is characterized by recurrent subacute encephalopathy, has_symptom confusion, has_symptom seizure, has_symptom ataxia, has_symptom dystonia, has_symptom supranuclear facial palsy, has_symptom external ophthalmoplegia, and has_symptom dysphagia. http://purl.obolibrary.org/obo/DOID_0050660 Beare-Stevenson cutis gyrata syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by cutis gyrata, acanthosis nigricans and craniosynostosis, has_material_basis_in heterozygous mutation in the FGFR2 gene on chromosome 10q26. http://purl.obolibrary.org/obo/DOID_0050661 vitelliform macular dystrophy http://purl.obolibrary.org/obo/DOID_4448 macular degeneration A macular degeneration that it is characterized by the disruption of cells in a small area near the center of the retina, the macula and may cause progressive vision loss. http://purl.obolibrary.org/obo/DOID_0050662 bestrophinopathy http://purl.obolibrary.org/obo/DOID_4448 macular degeneration A macular degeneration that is characterized by central vision loss, an absent electrooculogram light rise and a reduced electroretinogram, has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the BEST1 gene on chromosome 11q12. http://purl.obolibrary.org/obo/DOID_0050663 Bethlem myopathy http://purl.obolibrary.org/obo/DOID_0050557 congenital muscular dystrophy A congenital muscular dystrophy that is characterized by myopathy and joint contractures that progresses slowly, has_material_basis_in autosomal dominant inheritance of heterozygous mutation in the COL6A1 gene, the COL6A2 gene, or the COL6A3 gene. http://purl.obolibrary.org/obo/DOID_0050665 fetal alcohol syndrome http://purl.obolibrary.org/obo/DOID_0050696 fetal alcohol spectrum disorder A fetal alcohol spectrum disorder that results in severe mental and physical defects which can develop in a child when the mother drinks alcohol during pregnancy. The presenting features include craniofacial dysmorphology (microcephaly, smooth philtrum, thin upper lip, small eye openings), pre- and postnatal growth deficiency, and central nervous system dysfunction. http://purl.obolibrary.org/obo/DOID_0050666 partial fetal alcohol syndrome http://purl.obolibrary.org/obo/DOID_0050696 fetal alcohol spectrum disorder A fetal alcohol spectrum disorder that results in most, but not all, of the growth deficiency and/or craniofacial features of fetal alcohol syndrome including central nervous system dysfunction due to prenatal alcohol exposure. http://purl.obolibrary.org/obo/DOID_0050667 alcohol-related neurodevelopmental disorder http://purl.obolibrary.org/obo/DOID_0050696 fetal alcohol spectrum disorder A fetal alcohol spectrum disorder that results in central nervous system dysfunction and behavioral and/or cognitive deficits due to prenatal alcohol exposure. http://purl.obolibrary.org/obo/DOID_0050669 spastic cerebral palsy http://purl.obolibrary.org/obo/DOID_1969 cerebral palsy A cerebral palsy that is caused by damage in the outer layer of the brain, the cerebral cortex, which results in increased tone, or tension, in a muscle causing abnormal movements. http://purl.obolibrary.org/obo/DOID_0050670 ataxic cerebral palsy http://purl.obolibrary.org/obo/DOID_1969 cerebral palsy A cerebral palsy that is caused by damage to the cerebellum, which affects muscle coordination, particularly in the limb. Some individuals suffer from hypotonia, tremors, difficulty with visual and/or auditory processing. http://purl.obolibrary.org/obo/DOID_0050674 congenital bile acid synthesis defect http://purl.obolibrary.org/obo/DOID_1701 steroid inherited metabolic disorder A steroid inherited metabolic disorder characterized by abnormal conversion of cholesterol into bile acids which occurs predominantly in the liver. http://purl.obolibrary.org/obo/DOID_0050675 Birk-Barel syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by intellectual disability, hypotonia, hyperactivity and facies, has_material_basis_in heterozygous mutation in the KCNK9 gene on chromosome 8q24. http://purl.obolibrary.org/obo/DOID_0050676 Birt-Hogg-Dube syndrome http://purl.obolibrary.org/obo/DOID_37 skin disease A skin disease that is characterized by the development of skin papules on the head, face and upper torso, has_material_basis_in heterozygous mutation in the gene encoding folliculin on chromosome 17p11. http://purl.obolibrary.org/obo/DOID_0050678 Blau syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by familial granulomatous arthritis, uveitis and skin granulomas. It has_material_basis_in heterozygous mutations in the NOD2 gene. http://purl.obolibrary.org/obo/DOID_0050679 blue cone monochromacy http://purl.obolibrary.org/obo/DOID_13911 achromatopsia An achromatopsia that is characterized by severely impaired color discrimination, low visual acuity, nystagmus, photophobia due to the absence of functional long wavelength-sensitive and medium wavelength-sensitive cones in the retina and has_material_basis_in recessive X-linked inheritance. http://purl.obolibrary.org/obo/DOID_0050680 Boomerang dysplasia http://purl.obolibrary.org/obo/DOID_2256 osteochondrodysplasia An osteochondrodysplasia that is characterized by severe dwarfism, dislocated joints, club feet, distinctive facies and dysplastic tubular bones with boomerang-like bowing, has_material_basis_in heterozygous mutation in the FLNB gene on chromosome 3p14. http://purl.obolibrary.org/obo/DOID_0050681 Borjeson-Forssman-Lehmann syndrome http://purl.obolibrary.org/obo/DOID_0080012 X-linked recessive disease An X-linked disease that is characterized by intellectual disability, truncal obesity, seizures, hypogonadism, developmental delay, distinctive facial features, tapered fingers and short toes and has_material_basis_in X-linked recessive inheritance of mutations in the PHF6 gene. http://purl.obolibrary.org/obo/DOID_0050684 Bowen-Conradi syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by growth delays, failure to thrive and malformations of the head and face that results in infantile death, has_material_basis_in homozygous mutation in the EMG1 gene on chromosome 12p13. http://purl.obolibrary.org/obo/DOID_0050685 small cell carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A carcinoma that is an undifferentiated neoplasm composed of primitive-appearing cells. http://purl.obolibrary.org/obo/DOID_0050686 organ system cancer http://purl.obolibrary.org/obo/DOID_162 cancer A cancer that is classified based on the organ it starts in. http://purl.obolibrary.org/obo/DOID_0050687 cell type cancer http://purl.obolibrary.org/obo/DOID_162 cancer A cancer that is classified by the type of cell from which it is derived. http://purl.obolibrary.org/obo/DOID_0050688 anal canal cancer http://purl.obolibrary.org/obo/DOID_5672 large intestine cancer A large intestine cancer that is located_in the terminal part of the large intestine. http://purl.obolibrary.org/obo/DOID_0050689 brachydactyly-syndactyly syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by brachydactyly and syndactyly, has_material_basis_in heterozygous mutation in the HOXD13 gene on chromosome 2q31. http://purl.obolibrary.org/obo/DOID_0050690 brachyolmia http://purl.obolibrary.org/obo/DOID_2256 osteochondrodysplasia An osteochondrodysplasia characterized by generalized platyspondyly without significant long bone abnormalities and short stature. http://purl.obolibrary.org/obo/DOID_0050691 branchiooculofacial syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by low birth weight and growth retardation, bilateral branchial clefts. http://purl.obolibrary.org/obo/DOID_0050693 Brooke-Spiegler syndrome http://purl.obolibrary.org/obo/DOID_37 skin disease A skin disease that is characterized by the development of several types of tumors from the skin, has_material_basis_in heterozygous mutation in the CYLD gene on chromosome 16q12. http://purl.obolibrary.org/obo/DOID_0050694 Brown-Vialetto-Van Laere syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by sensorineural hearing loss and a variety of cranial nerve palsies, usually involving the motor components of the seventh and ninth to twelfth cranial nerves. http://purl.obolibrary.org/obo/DOID_0050696 fetal alcohol spectrum disorder http://purl.obolibrary.org/obo/DOID_0060038 specific developmental disorder A specific developmental disorder and physical disorder that is characterized by physical, behavioral and learning birth defects resulting from maternal ingestion of alcohol during pregnancy. http://purl.obolibrary.org/obo/DOID_0050697 chorioamnionitis http://purl.obolibrary.org/obo/DOID_780 placenta disease A placenta disease that is an inflammation of the fetal membranes (amnion and chorion) due to a bacterial infection. http://purl.obolibrary.org/obo/DOID_0050698 funisitis http://purl.obolibrary.org/obo/DOID_65 connective tissue disease A connective tissue disease that is an inflammation of the connective tissue of the umbilical cord. http://purl.obolibrary.org/obo/DOID_0050700 cardiomyopathy http://purl.obolibrary.org/obo/DOID_114 heart disease A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle. http://purl.obolibrary.org/obo/DOID_0050701 electroclinical syndrome http://purl.obolibrary.org/obo/DOID_1826 epilepsy An epilepsy syndrome that is a group of clinical entities showing a cluster of electro-clinical characteristics, classified according to age at onset, cognitive and developmental antecedents and consequences, motor and sensory examinations, EEG features, provoking or triggering factors, and patterns of seizure occurrence with respect to sleep. http://purl.obolibrary.org/obo/DOID_0050702 neonatal period electroclinical syndrome http://purl.obolibrary.org/obo/DOID_0050701 electroclinical syndrome An electroclinical syndrome with onset in the neonatal period less than 44 weeks of gestational age. http://purl.obolibrary.org/obo/DOID_0050703 infancy electroclinical syndrome http://purl.obolibrary.org/obo/DOID_0050701 electroclinical syndrome An electroclinical syndrome with onset in infancy occurring between birth and one year of age. http://purl.obolibrary.org/obo/DOID_0050704 childhood electroclinical syndrome http://purl.obolibrary.org/obo/DOID_0070309 absence epilepsy An electroclinical syndrome with onset in childhood between one and 12 years of age. http://purl.obolibrary.org/obo/DOID_0050705 adolescence-adult electroclinical syndrome http://purl.obolibrary.org/obo/DOID_0070309 absence epilepsy An electroclinical syndrome with onset in adolescence and adulthood. http://purl.obolibrary.org/obo/DOID_0050706 variable age at onset electroclinical syndrome http://purl.obolibrary.org/obo/DOID_0050701 electroclinical syndrome An electroclinial syndrome that is characterized by development of seizures later in life with a variable age of onset and duration. http://purl.obolibrary.org/obo/DOID_0050708 early onset absence epilepsy http://purl.obolibrary.org/obo/DOID_0050704 childhood electroclinical syndrome A childhood electroclinical syndrome characterized by the occurrence of typical absence seizures starting between the age of four and ten years. http://purl.obolibrary.org/obo/DOID_0050709 early infantile epileptic encephalopathy http://purl.obolibrary.org/obo/DOID_0050702 neonatal period electroclinical syndrome A neonatal period electroclinical syndrome that is characterized by tonic spasms and partial seizures. http://purl.obolibrary.org/obo/DOID_0050710 3-Methylcrotonyl-CoA carboxylase deficiency http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder An amino acid metabolic disorder that is classified by inadequate levels of the enzyme 3-methylcrotonyl-CoA carboxylase that helps break down proteins containing the amino acid leucine. This disease has_symptom muscular hypotonia (weak muscle tone), has_symptom muscular atrophy, has_symptom feeding difficulties, has_symptom recurrent episodes of vomiting and diarrhea, and has_symptom lethargy. http://purl.obolibrary.org/obo/DOID_0050711 aceruloplasminemia http://purl.obolibrary.org/obo/DOID_2351 iron metabolism disease An iron metabolism disease that has_material_basis_in a mutation in the ceruloplasmin gene characterized by progressive neurodegeneration of the retina and basal ganglia and diabetes mellitus. http://purl.obolibrary.org/obo/DOID_0050712 AGAT deficiency http://purl.obolibrary.org/obo/DOID_0050798 cerebral creatine deficiency syndrome An amino acid metabolic disorder that has_material_basis_in a mutation in the GATM gene resulting in deficiency of arginine:glycine amidinotransferase which then limits creatine synthesis. http://purl.obolibrary.org/obo/DOID_0050718 vitamin metabolic disorder http://purl.obolibrary.org/obo/DOID_655 inherited metabolic disorder An inherited metabolic disorder resulting from a deficiency in vitamin or vitamin cofactor transport or metabolism. http://purl.obolibrary.org/obo/DOID_0050720 ornithine translocase deficiency http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder An amino acid metabolic disorder that has_material_basis in deficiency of ornithine translocase resulting in the accumulation of ammonia in the blood. http://purl.obolibrary.org/obo/DOID_0050721 serine deficiency http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder An amino acid metabolic disorder that has_material_basis_in defects in the biosynthesis of the amino acid L-serine. http://purl.obolibrary.org/obo/DOID_0050727 tyrosinemia type III http://purl.obolibrary.org/obo/DOID_9275 tyrosinemia A tyrosinemia that has_material_basis_in deficiency of 4-hydroxyphenylpyruvate dioxygenase disrupting the break down of tyrosine. http://purl.obolibrary.org/obo/DOID_0050728 glycogen metabolism disorder http://purl.obolibrary.org/obo/DOID_2978 carbohydrate metabolic disorder A carbohydrate metabolism disorder that is characterized by abnormal accumulation or depletion of liver glycogen. http://purl.obolibrary.org/obo/DOID_0050729 neutral lipid storage disease http://purl.obolibrary.org/obo/DOID_9455 lipid storage disease A lipid storage disease that is characterized by accumulation of triglycerides in the cytoplasm of leukocytes, muscle, liver, fibroblasts, and other tissues. http://purl.obolibrary.org/obo/DOID_0050730 coenzyme Q10 deficiency disease http://purl.obolibrary.org/obo/DOID_700 mitochondrial metabolism disease A mitochondrial metabolism disease that is characterized by a deficiency of CoQ10 resulting from reduced biosynthesis. http://purl.obolibrary.org/obo/DOID_0050731 vitamin B12 deficiency http://purl.obolibrary.org/obo/DOID_0050718 vitamin metabolic disorder A vitamin metabolic disorder that results from low blood levels of vitamin B12. http://purl.obolibrary.org/obo/DOID_0050735 X-linked monogenic disease http://purl.obolibrary.org/obo/DOID_0050177 monogenic disease A monogenic disease that has_material_basis_in muations in genes on the X chromosome. http://purl.obolibrary.org/obo/DOID_0050736 autosomal dominant disease http://purl.obolibrary.org/obo/DOID_0050739 autosomal genetic disease An autosomal genetic disease that is characterized by the presence of one disease-associated mutation of a gene which is sufficient to cause the disease. http://purl.obolibrary.org/obo/DOID_0050737 autosomal recessive disease http://purl.obolibrary.org/obo/DOID_0050739 autosomal genetic disease An autosomal genetic disease that is characterized by the presence of two mutated copies of the gene, both of which must be present in order for the disease or trait to develop. http://purl.obolibrary.org/obo/DOID_0050739 autosomal genetic disease http://purl.obolibrary.org/obo/DOID_0050177 monogenic disease A monogenic disease that has_material_basis_in a mutation in a single gene on one of the non-sex chromosomes. http://purl.obolibrary.org/obo/DOID_0050741 alcohol dependence http://purl.obolibrary.org/obo/DOID_9973 substance dependence A substance dependence that is characterized by tolerance, withdrawal symptoms, increasing use, persistent desire to decrease consumption, time spent obtaining or recovering from alcohol caused by a physical and psychological dependence on alcohol. http://purl.obolibrary.org/obo/DOID_0050742 nicotine dependence http://purl.obolibrary.org/obo/DOID_9973 substance dependence A substance dependence that is characterized by a physical dependence on nicotine. http://purl.obolibrary.org/obo/DOID_0050743 mature T-cell and NK-cell lymphoma http://purl.obolibrary.org/obo/DOID_0060060 non-Hodgkin lymphoma A non-Hodgkin lymphoma that has_material_basis_in mature T lymphocytes and natural killer cells. http://purl.obolibrary.org/obo/DOID_0050744 anaplastic large cell lymphoma http://purl.obolibrary.org/obo/DOID_0060060 non-Hodgkin lymphoma A non-Hodgkin lymphoma involving aberrant T-cells. http://purl.obolibrary.org/obo/DOID_0050745 diffuse large B-cell lymphoma http://purl.obolibrary.org/obo/DOID_707 B-cell lymphoma A B-cell lymphoma that is a cancer of B cells presenting as an aggressive tumour which can arise in virtually any part of the body. http://purl.obolibrary.org/obo/DOID_0050746 mantle cell lymphoma http://purl.obolibrary.org/obo/DOID_707 B-cell lymphoma A B-cell lymphocytic neoplasm due to CD5 positive antigen-naive pregerminal center B-cell within the mantle zone that surrounds normal germinal center follicles. http://purl.obolibrary.org/obo/DOID_0050748 marginal zone B-cell lymphoma http://purl.obolibrary.org/obo/DOID_9500 leukocyte disease A B-cell lymphoma that is characterized by initial formation in the marginal zones of lymph tissue. http://purl.obolibrary.org/obo/DOID_0050749 peripheral T-cell lymphoma http://purl.obolibrary.org/obo/DOID_0050743 mature T-cell and NK-cell lymphoma A mature T-cell and NK-cell lymphoma includes a group of T-cell lymphomas that develop away from the thymus. http://purl.obolibrary.org/obo/DOID_0050750 splenic marginal zone lymphoma http://purl.obolibrary.org/obo/DOID_672 spleen cancer A marginal zone B-cell lymphocyte located_in the spleen comprised of B-cells in place of white pulp. http://purl.obolibrary.org/obo/DOID_0050753 cerebellar ataxia http://purl.obolibrary.org/obo/DOID_2786 cerebellar disease A hereditary ataxia that is characterized by ataxia originating in the cerebellum. http://purl.obolibrary.org/obo/DOID_0050755 ataxia with oculomotor apraxia type 2 http://purl.obolibrary.org/obo/DOID_0050950 autosomal recessive cerebellar ataxia An autosomal recessive cerebellar ataxia that is characterized by the onset of ataxia between age three and thirty including axonal sensorimotor neuropathy, oculomotor apraxia, cerebellar atrophy and elevated alpha-fetoprotein, has_material_basis_in homozygous or compound heterozygous mutation in the SETX gene on chromosome 9q34. http://purl.obolibrary.org/obo/DOID_0050757 deafness-dystonia-optic neuronopathy syndrome http://purl.obolibrary.org/obo/DOID_700 mitochondrial metabolism disease A mitochondrial metabolism disease that is characterized by hearing loss that begins early in life, problems with movement, impaired vision, and behavior problems, and has_material_basis_in mutations in the TIMM8A gene resulting in abnormal protein transport within the mitochondria. http://purl.obolibrary.org/obo/DOID_0050758 metabolic acidosis http://purl.obolibrary.org/obo/DOID_0060158 acquired metabolic disease An acquired metabolic disease that characterized by excessive production of acid. http://purl.obolibrary.org/obo/DOID_0050759 myotonic dystrophy type 2 http://purl.obolibrary.org/obo/DOID_450 myotonic disease A myotonic disease that is characterized by myotonia and progressive, proximal muscle wasting and weakness affecting the skeletal and smooth muscles of the neck, shoulders, elbows and hips and has_material_basis_in the autosomal dominant inheritance of the CNBP (ZNF9) gene containing an expansion of a CCTG repeat in intron one. http://purl.obolibrary.org/obo/DOID_0050763 ARC syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by congenital joint contractures, renal tubular dysfunction, cholestasis, severe failure to thrive, ichthyosis and a defect in platelet alpha-granule biogenesis and that has_material_basis_in homozygous or compound heterozygous mutation in the VPS33B gene or homozygous or compound heterozygous mutation in the VIPAR gene on chromosome 14q24.3. http://purl.obolibrary.org/obo/DOID_0050765 neuroacanthocytosis http://purl.obolibrary.org/obo/DOID_1289 neurodegenerative disease A neurodegenerative disease that is characterized by characterized by misshapen, spiny red blood cells (acanthocytosis) and neurological abnormalities, especially movement disorders. http://purl.obolibrary.org/obo/DOID_0050766 choreaacanthocytosis http://purl.obolibrary.org/obo/DOID_0050765 neuroacanthocytosis A neuroacanthocytosis characterized by progressive neurodegeneration and red cell acanthocytosis, with onset in the third to fifth decade of life and has_material_basis_in homozygous or compound heterozygous mutation in the VPS13A gene, which encodes chorein, on chromosome 9q21. http://purl.obolibrary.org/obo/DOID_0050769 N syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by intellectual disability, deafness, ocular abnormalities, T-cell leukemia, cryptorchidism, hypospadias and spasticity. http://purl.obolibrary.org/obo/DOID_0050770 polycystic liver disease http://purl.obolibrary.org/obo/DOID_409 liver disease A liver disease that is characterized by the presence of multiple cysts located_in the liver. http://purl.obolibrary.org/obo/DOID_0050771 pheochromocytoma http://purl.obolibrary.org/obo/DOID_0060089 endocrine organ benign neoplasm An endocrine organ benign neoplasm that arises within the adrenal medulla, releasing epinephrines and norepinephrines hormones that cause either episodic or persistent high blood pressure. http://purl.obolibrary.org/obo/DOID_0050773 paraganglioma http://purl.obolibrary.org/obo/DOID_0050771 pheochromocytoma A pheochromocytoma that arises in extraadrenal sympathetic ganglia. http://purl.obolibrary.org/obo/DOID_0050774 rapadilino syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by radial ray defect, patellae hypoplasia, cleft palate, diarrhea, dislocated joints, limb malformations, long nose and normal intelligence, has_material_basis_in homozygous or compound heterozygous mutation in the DNA helicase gene RECQL4 on chromosome 8q24. http://purl.obolibrary.org/obo/DOID_0050775 schneckenbecken dysplasia http://purl.obolibrary.org/obo/DOID_2256 osteochondrodysplasia An osteochondrodysplasia that is characterized by hypoplastic iliac bones, hypoplastic vertebral bodies, short ribs and broad long bones, prenatally lethal, has_material_basis_in homozygous or compound heterozygous mutation in the SLC35D1 gene on chromosome 1p31. http://purl.obolibrary.org/obo/DOID_0050776 non-syndromic X-linked intellectual disability http://purl.obolibrary.org/obo/DOID_0050889 non-syndromic intellectual disability A non-syndromic intellectual disability characterized by a X-linked inheritance pattern. http://purl.obolibrary.org/obo/DOID_0050798 cerebral creatine deficiency syndrome http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder An amino acid metabolic disorder that is characterized by mental retardation, severe speech delay, behavioral abnormalities and seizures, has_material_basis_in mutation in the creatine transporter gene on chromosome Xq28. http://purl.obolibrary.org/obo/DOID_0050820 atrioventricular block http://purl.obolibrary.org/obo/DOID_10273 heart conduction disease A heart conduction disease that is characterized by the impairment of the conduction between the atria and ventricles of the heart. http://purl.obolibrary.org/obo/DOID_0050824 sinoatrial node disease http://purl.obolibrary.org/obo/DOID_10273 heart conduction disease A heart conduction disease that is characterized by dysfunction of the impulse-generating (pacemaker) tissue located in the right atrium of the heart which generates normal sinus rhythm. http://purl.obolibrary.org/obo/DOID_0050825 endocardium disease http://purl.obolibrary.org/obo/DOID_114 heart disease A heart disease that is located_in the innermost layer of tissue that lines the chambers of the heart. http://purl.obolibrary.org/obo/DOID_0050826 tricuspid valve disease http://purl.obolibrary.org/obo/DOID_4079 heart valve disease A heart valve disease that is characterized by valvular insufficiency or valvular stenosis, located_in tricuspid valve between the right atrium and right ventricle. http://purl.obolibrary.org/obo/DOID_0050828 artery disease http://purl.obolibrary.org/obo/DOID_178 vascular disease A vascular disease that is located_in an artery. http://purl.obolibrary.org/obo/DOID_0050829 pericardium disease http://purl.obolibrary.org/obo/DOID_1287 cardiovascular system disease A cardiovascular system disease that is located_in the fibrous sac surrounding the heart. http://purl.obolibrary.org/obo/DOID_0050836 focal dystonia http://purl.obolibrary.org/obo/DOID_543 dystonia A dystonia that is localized to a specific part of the body. http://purl.obolibrary.org/obo/DOID_0050845 cranio-facial dystonia http://purl.obolibrary.org/obo/DOID_0050836 focal dystonia A focal dystonia that is characterized as dystonia that affects the muscles of the head, face, and neck. http://purl.obolibrary.org/obo/DOID_0050847 sleep apnea http://purl.obolibrary.org/obo/DOID_535 sleep disorder A sleep disorder characterized by repeated cessation and commencing of breathing that repeatedly disrupts sleep. http://purl.obolibrary.org/obo/DOID_0050851 glomerulosclerosis http://purl.obolibrary.org/obo/DOID_2921 glomerulonephritis A glomerulonephritis that is characterized by hardening of the glomerulus in the kidney. http://purl.obolibrary.org/obo/DOID_0050888 syndromic intellectual disability http://purl.obolibrary.org/obo/DOID_1059 intellectual disability An intellectual disability that is characterized by the presence of associated medical and behavioral sign and symptoms. http://purl.obolibrary.org/obo/DOID_0050889 non-syndromic intellectual disability http://purl.obolibrary.org/obo/DOID_1059 intellectual disability An intellectual disability that is characterized by the absence of associated medical and behavioral signs and symptoms. http://purl.obolibrary.org/obo/DOID_0050890 synucleinopathy http://purl.obolibrary.org/obo/DOID_1289 neurodegenerative disease A neurodegenerative disease that is characterized by the abnormal accumulation of aggregates of alpha-synuclein protein in neurons, nerve fibres or glial cells. http://purl.obolibrary.org/obo/DOID_0050902 medulloblastoma http://purl.obolibrary.org/obo/DOID_4706 infratentorial cancer An infratentorial cancer that is located_in the lower part of the brain and is a type of primitive neuroectodermal tumor. http://purl.obolibrary.org/obo/DOID_0050904 salivary gland carcinoma http://purl.obolibrary.org/obo/DOID_8850 salivary gland cancer A salivary gland cancer that has_material_basis_in epithelial cells. http://purl.obolibrary.org/obo/DOID_0050938 breast lobular carcinoma http://purl.obolibrary.org/obo/DOID_3459 breast carcinoma A breast carcinoma that derives_from breast lobules (milk glands). http://purl.obolibrary.org/obo/DOID_0050950 autosomal recessive cerebellar ataxia http://purl.obolibrary.org/obo/DOID_0050753 cerebellar ataxia A cerebellar ataxia that has_material_basis_in autosomal recessive inheritance. http://purl.obolibrary.org/obo/DOID_0050951 hereditary ataxia http://purl.obolibrary.org/obo/DOID_1289 neurodegenerative disease A neurodegenerative disease that is characterized by slowly progressive incoordination of gait and often associated with poor coordination of hands, speech, and eye movements. http://purl.obolibrary.org/obo/DOID_0060000 infective endocarditis http://purl.obolibrary.org/obo/DOID_10314 endocarditis An endocarditis that is characterized by inflammation of the endocardium caused by infectious agents. http://purl.obolibrary.org/obo/DOID_0060001 withdrawal disorder http://purl.obolibrary.org/obo/DOID_303 substance-related disorder A substance-related disorder that occurs upon the abrupt discontinuation/separation or a decrease in dosage of the intake of medications, recreational drugs, and alcohol. http://purl.obolibrary.org/obo/DOID_0060002 C1 inhibitor deficiency http://purl.obolibrary.org/obo/DOID_626 complement deficiency A complement deficiency that is a functional deficiency in the complement component C1 inhibitor leading to hereditary angioedema (HAE) involving swelling due to leakage of fluid from blood vessels into connective tissue. http://purl.obolibrary.org/obo/DOID_0060004 autoimmune disease of central nervous system http://purl.obolibrary.org/obo/DOID_438 autoimmune disease of the nervous system An autoimmune hypersensitivity disease located_in the central nervous system. http://purl.obolibrary.org/obo/DOID_0060005 autoimmune disease of endocrine system http://purl.obolibrary.org/obo/DOID_417 autoimmune disease An autoimmune disease that is the abnormal functioning of the immune system resulting in production of antibodies or T cells against cells and/or tissues in the endocrine system. http://purl.obolibrary.org/obo/DOID_0060009 MHC class I deficiency http://purl.obolibrary.org/obo/DOID_627 severe combined immunodeficiency A severe combined immunodeficiency that is characterized by recurrent bacterial, viral, and fungal infections, especially of the lung, and sterile necrotizing granulomas of the skin, develops_from deficiency or decreased surface expression of MHC Class I, has_material_basis_in autosomal recessive inheritance of mutation affecting MHC Class I production or expression and frequently involves TAP1 and TAP2 subunits, and is typically asymptomatic in infancy. http://purl.obolibrary.org/obo/DOID_0060010 Omenn syndrome http://purl.obolibrary.org/obo/DOID_627 severe combined immunodeficiency A severe combined immunodeficiency that has_material_basis in the RAG1 and RAG2 genes on chromosome 11p and the Artemis gene on chromosome 10p. It is characterized by erythroderma, desquamation, alopecia, chronic diarrhea, failure to thrive, lymphadenopathy, and hepatosplenomegaly. http://purl.obolibrary.org/obo/DOID_0060013 X-linked severe combined immunodeficiency http://purl.obolibrary.org/obo/DOID_627 severe combined immunodeficiency A severe combined immunodeficiency that is a X-linked SCID that has_material_basis_in mutations in genes encoding common gamma chain proteins shared by the interleukin (IL-2,4,7,9,16 and21) receptors resulting in a non-functional gamma chain, defective interleukin signalling, minimal or ascent T- and NK cells and non-functional B-cells. http://purl.obolibrary.org/obo/DOID_0060019 coronin-1A deficiency http://purl.obolibrary.org/obo/DOID_627 severe combined immunodeficiency A severe combined immunodeficiency that is an actin regulator when mutated results in SCID through inhibition of thymic egress of mature thymocytes into peripheral lymphoid organs. http://purl.obolibrary.org/obo/DOID_0060020 reticular dysgenesis http://purl.obolibrary.org/obo/DOID_627 severe combined immunodeficiency A severe combined immunodeficiency that is the most severe form of SCID and has_material_basis_in mutations in the gene encoding mitochondrial adenylate kinase 2. It is characterized by congenital agranulocytosis, lymphopenia, and lymphoid and thymic hypoplasia with absent cellular and humoral immunity functions. http://purl.obolibrary.org/obo/DOID_0060021 DNA ligase IV deficiency http://purl.obolibrary.org/obo/DOID_628 combined T cell and B cell immunodeficiency A combined T cell and B cell immunodeficiency that has_material_basis_in a mutation in the LIG4 gene, a DNA ligase, encoding a protein essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). Patients present with immunodeficiency and developmental and growth delay. http://purl.obolibrary.org/obo/DOID_0060022 CD40 ligand deficiency http://purl.obolibrary.org/obo/DOID_628 combined T cell and B cell immunodeficiency A combined T cell and B cell immunodeficiency that is a X-linked immunodeficiency with hyperimmunoglobulin M (XHIM) affecting isotype switching and is caused by the absence of CD40 ligand which is normally expressed on activated CD4+ T cells. Individuals with this mutation are unable to switch from IgM to IgG, IgA and IgE. http://purl.obolibrary.org/obo/DOID_0060025 immunoglobulin alpha deficiency http://purl.obolibrary.org/obo/DOID_2115 B cell deficiency A B cell deficiency that is an autosomal recessive disorder that has_material_basis_in mutation in the IgA (CD79 alpha) antigen receptor. http://purl.obolibrary.org/obo/DOID_0060028 Good syndrome http://purl.obolibrary.org/obo/DOID_628 combined T cell and B cell immunodeficiency A combined T cell and B cell immunodeficiency that is a condition where there is co-occurrence of deficient cell-mediated immunity and benign thymoma. http://purl.obolibrary.org/obo/DOID_0060029 autoimmune disease of exocrine system http://purl.obolibrary.org/obo/DOID_417 autoimmune disease An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the exocrine system. http://purl.obolibrary.org/obo/DOID_0060031 autoimmune disease of gastrointestinal tract http://purl.obolibrary.org/obo/DOID_77 gastrointestinal system disease An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the gastrointestinal tract. http://purl.obolibrary.org/obo/DOID_0060032 autoimmune disease of musculoskeletal system http://purl.obolibrary.org/obo/DOID_417 autoimmune disease An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the musculoskeletal system. http://purl.obolibrary.org/obo/DOID_0060033 autoimmune disease of peripheral nervous system http://purl.obolibrary.org/obo/DOID_574 peripheral nervous system disease An autoimmune disease of the nervous system that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the peripheral nervous system. http://purl.obolibrary.org/obo/DOID_0060036 intrinsic cardiomyopathy http://purl.obolibrary.org/obo/DOID_0050700 cardiomyopathy A cardiomyopathy that is characterized as weakness in the muscle of the heart that is not due to an identifiable external cause. http://purl.obolibrary.org/obo/DOID_0060037 developmental disorder of mental health http://purl.obolibrary.org/obo/DOID_150 disease of mental health A disease of mental health that occur during a child's developmental period between birth and age 18 resulting in retarding of the child's psychological or physical development. http://purl.obolibrary.org/obo/DOID_0060038 specific developmental disorder http://purl.obolibrary.org/obo/DOID_0060037 developmental disorder of mental health A developmental disorder of mental health that categorizes specific learning disabilities and developmental disorders affecting coordination. http://purl.obolibrary.org/obo/DOID_0060039 autoimmune disease of skin and connective tissue http://purl.obolibrary.org/obo/DOID_65 connective tissue disease An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the skin and connective tissue. http://purl.obolibrary.org/obo/DOID_0060040 pervasive developmental disorder http://purl.obolibrary.org/obo/DOID_0060037 developmental disorder of mental health A developmental disorder of mental health that refers to a group of five disorders characterized by impairments in socialization and communication, as well as restricted interests and repetitive behaviors. http://purl.obolibrary.org/obo/DOID_0060041 autism spectrum disorder http://purl.obolibrary.org/obo/DOID_0060040 pervasive developmental disorder A pervasive developmental disorder that is a spectrum of psychological conditions. The disease has_symptom widespread abnormalities of social interactions and communication, has_symptom severely restricted interests and has_symptom highly repetitive behavior. http://purl.obolibrary.org/obo/DOID_0060042 atypical autism http://purl.obolibrary.org/obo/DOID_0060041 autism spectrum disorder An autism spectrum disorder that involves some autistic symptoms occuring after age 3 with an abscence of all the traits necessary for a diagnosis of autism. http://purl.obolibrary.org/obo/DOID_0060043 sexual disorder http://purl.obolibrary.org/obo/DOID_150 disease of mental health A disease of mental health that involves the impairment in normal sexual functioning. http://purl.obolibrary.org/obo/DOID_0060044 paraphilia disorder http://purl.obolibrary.org/obo/DOID_0060043 sexual disorder A sexual disorder that is characterized recurrent, intense sexually arousing fantasies, sexual urges or behaviors generally involving nonhuman objects. http://purl.obolibrary.org/obo/DOID_0060046 aphasia http://purl.obolibrary.org/obo/DOID_93 language disorder A language disorder that involves an acquired impairment of any laguage modality such as producting or comprehending spoken or written language. http://purl.obolibrary.org/obo/DOID_0060047 writing disorder http://purl.obolibrary.org/obo/DOID_8927 learning disability A learning disability that involves impaired written language ability such as impairments in handwriting, spelling, organization of ideas, and composition. http://purl.obolibrary.org/obo/DOID_0060049 autoimmune disease of urogenital tract http://purl.obolibrary.org/obo/DOID_417 autoimmune disease An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the urogenital tract. http://purl.obolibrary.org/obo/DOID_0060050 autoimmune disease of blood http://purl.obolibrary.org/obo/DOID_417 autoimmune disease An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the blood. http://purl.obolibrary.org/obo/DOID_0060051 autoimmune disease of cardiovascular system http://purl.obolibrary.org/obo/DOID_417 autoimmune disease An autoimmune disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the cardiovascular system. http://purl.obolibrary.org/obo/DOID_0060056 hypersensitivity reaction disease http://purl.obolibrary.org/obo/DOID_2914 immune system disease An immune system disease that has_material_basis_in abnormal immune responses. http://purl.obolibrary.org/obo/DOID_0060058 lymphoma http://purl.obolibrary.org/obo/DOID_2531 hematologic cancer A hematologic cancer that affects lymphocytes that reside in the lymphatic system and in blood-forming organs. http://purl.obolibrary.org/obo/DOID_0060060 non-Hodgkin lymphoma http://purl.obolibrary.org/obo/DOID_0060058 lymphoma A lymphoma that is characterized as any kind of lymphoma except Hodgkin's lymphoma. http://purl.obolibrary.org/obo/DOID_0060061 cutaneous T cell lymphoma http://purl.obolibrary.org/obo/DOID_0050749 peripheral T-cell lymphoma A non-Hodgkin's lymphoma that has_material_basis_in a mutation of T cells. http://purl.obolibrary.org/obo/DOID_0060062 familial juvenile hyperuricemic nephropathy http://purl.obolibrary.org/obo/DOID_557 kidney disease A kidney disease that is characterized by hyperuricemia with renal uric acid under-excretion, gout and chronic kidney disease. http://purl.obolibrary.org/obo/DOID_0060066 pyridoxine-responsive sideroblastic anemia http://purl.obolibrary.org/obo/DOID_8955 sideroblastic anemia A sideoblastic anemia that is characterized by the presence of microcytic hypochromic anemia and iron overload, and has_material_basis_in X-linked inheritance. http://purl.obolibrary.org/obo/DOID_0060067 Pearson syndrome http://purl.obolibrary.org/obo/DOID_700 mitochondrial metabolism disease A mitochondrial metabolism disease that is characterized by sideroblastic anemia and exocrine pancreas dysfunction. http://purl.obolibrary.org/obo/DOID_0060071 pre-malignant neoplasm http://purl.obolibrary.org/obo/DOID_14566 disease of cellular proliferation A disease of cellular proliferation that results in abnormal growths in the body, which do not invade or destroy the surrounding tissue but, given enough time, will transform into a cancer. http://purl.obolibrary.org/obo/DOID_0060072 benign neoplasm http://purl.obolibrary.org/obo/DOID_14566 disease of cellular proliferation A disease of cellular proliferation that results in abnormal growths in the body which lack the ability to metastasize. http://purl.obolibrary.org/obo/DOID_0060073 lymphatic system cancer http://purl.obolibrary.org/obo/DOID_75 lymphatic system disease An immune system cancer that is located_in the lymphatic system and is characterized by uncontrolled cellular proliferation of lymphoid tissue. http://purl.obolibrary.org/obo/DOID_0060074 ductal carcinoma in situ http://purl.obolibrary.org/obo/DOID_8791 breast carcinoma in situ A breast carcinoma in situ that is characterized by being non-invasive, not having spread outside of the duct into the surrounding breast tissue, has_material_basis_in abnormally proliferating cells, derives_from epithelial cells. http://purl.obolibrary.org/obo/DOID_0060075 estrogen-receptor positive breast cancer http://purl.obolibrary.org/obo/DOID_1612 breast cancer A breast cancer that is characterized by the presence of estrogen receptors. http://purl.obolibrary.org/obo/DOID_0060082 breast benign neoplasm http://purl.obolibrary.org/obo/DOID_3463 breast disease A thoracic benign neoplasm that is characterized by lack of malignancy. http://purl.obolibrary.org/obo/DOID_0060083 immune system cancer http://purl.obolibrary.org/obo/DOID_2914 immune system disease An organ system cancer located_in the immune system that is characterized by uncontrolled cellular proliferation in organs of the immune system. http://purl.obolibrary.org/obo/DOID_0060084 cell type benign neoplasm http://purl.obolibrary.org/obo/DOID_0060072 benign neoplasm A benign neoplasm that is classified by the type of cell or tissue from which it is derived. http://purl.obolibrary.org/obo/DOID_0060085 organ system benign neoplasm http://purl.obolibrary.org/obo/DOID_0060072 benign neoplasm A benign neoplasm that is classified by the organ system from which it is arising from. http://purl.obolibrary.org/obo/DOID_0060086 female reproductive organ benign neoplasm http://purl.obolibrary.org/obo/DOID_229 female reproductive system disease A reproductive organ benign neoplasm that is characterized by a lack of malignancy located_in the female reproductive system. http://purl.obolibrary.org/obo/DOID_0060087 male reproductive organ benign neoplasm http://purl.obolibrary.org/obo/DOID_48 male reproductive system disease A reproductive organ benign neoplasm that is characterized by a lack of malignancy located_in the male reproductive system. http://purl.obolibrary.org/obo/DOID_0060089 endocrine organ benign neoplasm http://purl.obolibrary.org/obo/DOID_0060085 organ system benign neoplasm An organ system benign neoplasm that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body. http://purl.obolibrary.org/obo/DOID_0060090 central nervous system benign neoplasm http://purl.obolibrary.org/obo/DOID_331 central nervous system disease A nervous system benign neoplasm that is characterized by lack of malignancy. http://purl.obolibrary.org/obo/DOID_0060091 cardiovascular organ benign neoplasm http://purl.obolibrary.org/obo/DOID_1287 cardiovascular system disease An organ system benign neoplasm disease located_in the blood, heart, blood vessels or the lymphatic system. http://purl.obolibrary.org/obo/DOID_0060094 bone benign neoplasm http://purl.obolibrary.org/obo/DOID_0080001 bone disease A connective tissue benign neoplasm that is located_in bone. http://purl.obolibrary.org/obo/DOID_0060095 uterine benign neoplasm http://purl.obolibrary.org/obo/DOID_345 uterine disease A female reproductive organ benign neoplasm that is located_in the uterus. http://purl.obolibrary.org/obo/DOID_0060096 sensory organ benign neoplasm http://purl.obolibrary.org/obo/DOID_0060115 nervous system benign neoplasm A nervous system benign neoplasm that is located_in a sensory organ. http://purl.obolibrary.org/obo/DOID_0060097 thoracic benign neoplasm http://purl.obolibrary.org/obo/DOID_0060118 thoracic disease An organ system benign neoplam that is located_in the thoracic cavity. http://purl.obolibrary.org/obo/DOID_0060098 osteoblastoma http://purl.obolibrary.org/obo/DOID_0060094 bone benign neoplasm A bone benign neoplasm of the bone that is characterized by clinical and histological similarity to osteoid osteomas. http://purl.obolibrary.org/obo/DOID_0060099 musculoskeletal system benign neoplasm http://purl.obolibrary.org/obo/DOID_17 musculoskeletal system disease An organ system benign neoplasm that is located_in the muscular and skeletal organs. http://purl.obolibrary.org/obo/DOID_0060100 musculoskeletal system cancer http://purl.obolibrary.org/obo/DOID_17 musculoskeletal system disease An organ system cancer located_in the muscular and skeletal organs and characterized by uncontrolled cellular proliferation of the musculoskeletal organs. http://purl.obolibrary.org/obo/DOID_0060101 benign glioma http://purl.obolibrary.org/obo/DOID_936 brain disease A cell type benign neoplasm that has_material_basis_in glial cells. http://purl.obolibrary.org/obo/DOID_0060103 central nervous system primitive neuroectodermal neoplasm http://purl.obolibrary.org/obo/DOID_3620 central nervous system cancer A central nervous system cancer of children and young adults that develops from neural crest cells located_in cerebrum, has_material_basis_in abnormally proliferating cells derives_from neuroectoderm. http://purl.obolibrary.org/obo/DOID_0060108 brain glioma http://purl.obolibrary.org/obo/DOID_1319 brain cancer A brain cancer that has_material_basis_in glial cells. http://purl.obolibrary.org/obo/DOID_0060109 vulvar benign neoplasm http://purl.obolibrary.org/obo/DOID_2059 vulvar disease A female reproductive organ benign neoplasm that is located_in the vulva. http://purl.obolibrary.org/obo/DOID_0060112 ovarian benign neoplasm http://purl.obolibrary.org/obo/DOID_1100 ovarian disease A female reproductive organ benign neoplasm that is located_in the ovary. http://purl.obolibrary.org/obo/DOID_0060115 nervous system benign neoplasm http://purl.obolibrary.org/obo/DOID_863 nervous system disease An organ system benign neoplasm that is located_in the central nervous system or located_in the peripheral nervous system. http://purl.obolibrary.org/obo/DOID_0060116 sensory system cancer http://purl.obolibrary.org/obo/DOID_3093 nervous system cancer A nervous system cancer that is located in the sensory system. http://purl.obolibrary.org/obo/DOID_0060118 thoracic disease http://purl.obolibrary.org/obo/DOID_7 disease of anatomical entity A disease of anatomical entity that is located_in the thoracic cavity. http://purl.obolibrary.org/obo/DOID_0060119 pharynx cancer http://purl.obolibrary.org/obo/DOID_3119 gastrointestinal system cancer A gastrointestinal system cancer that is located_in the pharynx. http://purl.obolibrary.org/obo/DOID_0060121 integumentary system benign neoplasm http://purl.obolibrary.org/obo/DOID_16 integumentary system disease An organ system benign neoplasm located_in the integumentary system organs. http://purl.obolibrary.org/obo/DOID_0060122 integumentary system cancer http://purl.obolibrary.org/obo/DOID_16 integumentary system disease An organ system cancer that is located_in the skin, hair and nails. http://purl.obolibrary.org/obo/DOID_0060123 connective tissue benign neoplasm http://purl.obolibrary.org/obo/DOID_65 connective tissue disease A musculoskeletal system benign neoplasm that is located_in connective tissue. http://purl.obolibrary.org/obo/DOID_0060125 heavy chain disease http://purl.obolibrary.org/obo/DOID_2916 hypersensitivity reaction type IV disease A hypersensitivity reaction type IV disease that results from a proliferation of cells producing immunoglobulin heavy chains. http://purl.obolibrary.org/obo/DOID_0060126 alpha chain disease http://purl.obolibrary.org/obo/DOID_0060125 heavy chain disease A heavy chain disease that results from an overproduction of alpha antibodies (IgA). http://purl.obolibrary.org/obo/DOID_0060127 gamma heavy chain disease http://purl.obolibrary.org/obo/DOID_0060125 heavy chain disease A heavy chain disease that results from an overproduction of gamma antibody (IgG). http://purl.obolibrary.org/obo/DOID_0060128 mu chain disease http://purl.obolibrary.org/obo/DOID_0060125 heavy chain disease A heavy chain disease that results from an overproduction of mu antibody (IgM). http://purl.obolibrary.org/obo/DOID_0060131 alexithymia http://purl.obolibrary.org/obo/DOID_4090 agnosia An agnosia that is a deficiency in understanding, processing, or describing emotions. http://purl.obolibrary.org/obo/DOID_0060132 amusia http://purl.obolibrary.org/obo/DOID_4090 agnosia An agnosia that is a loss of the ability to recognize musical notes, rhythms, and intervals. http://purl.obolibrary.org/obo/DOID_0060133 anosognosia http://purl.obolibrary.org/obo/DOID_4090 agnosia An agnosia that is a loss of the ability to gain feedback about one's own condition or impairments. http://purl.obolibrary.org/obo/DOID_0060134 apperceptive agnosia http://purl.obolibrary.org/obo/DOID_4090 agnosia An agnosia that is a loss of the ability to distinguish visual shapes. http://purl.obolibrary.org/obo/DOID_0060135 apraxia http://purl.obolibrary.org/obo/DOID_4090 agnosia An agnosia that is a loss of the ability to map out physical actions in order to repeat them in functional activities. http://purl.obolibrary.org/obo/DOID_0060136 associative agnosia http://purl.obolibrary.org/obo/DOID_4090 agnosia An agnosia that is a loss of the ability to recognize visual scenes or classes of objects but retain the abilty to describe them. http://purl.obolibrary.org/obo/DOID_0060137 auditory agnosia http://purl.obolibrary.org/obo/DOID_4090 agnosia An agnosia that is a loss of the ability to distinguishing environmental and non-verbal auditory cues including difficulty distinguishing speech from non-speech sounds even though hearing is usually normal. http://purl.obolibrary.org/obo/DOID_0060140 cortical deafness http://purl.obolibrary.org/obo/DOID_4090 agnosia An agnosia that is a loss of the ability to perceive any auditory information but whose hearing is intact. http://purl.obolibrary.org/obo/DOID_0060141 finger agnosia http://purl.obolibrary.org/obo/DOID_4090 agnosia An agnosia that is a loss of the ability to distinguish the fingers on the hand. http://purl.obolibrary.org/obo/DOID_0060142 form agnosia http://purl.obolibrary.org/obo/DOID_4090 agnosia An agnosia that is a loss of the ability to perceive a whole object while perceiving only parts of details. http://purl.obolibrary.org/obo/DOID_0060145 pain agnosia http://purl.obolibrary.org/obo/DOID_4090 agnosia An agnosia that is a loss of the ability to perceive and process pain. http://purl.obolibrary.org/obo/DOID_0060148 simultanagnosia http://purl.obolibrary.org/obo/DOID_4090 agnosia An agnosia that is a loss of the ability to recgonize a whole image or scene while retianing the ability to recognize objects or details in their visual field one at a time. http://purl.obolibrary.org/obo/DOID_0060150 astereognosia http://purl.obolibrary.org/obo/DOID_4090 agnosia An agnosia that is the loss of the ability to recognize objects by touch based on its texture, size and weight. http://purl.obolibrary.org/obo/DOID_0060151 tactile agnosia http://purl.obolibrary.org/obo/DOID_4090 agnosia An agnosia that is a loss of the ability to recognize or identify objects by touch alone. http://purl.obolibrary.org/obo/DOID_0060154 verbal auditory agnosia http://purl.obolibrary.org/obo/DOID_4090 agnosia An agnosia that is a loss of the ability to recognising spoken words as semantically meaningful. http://purl.obolibrary.org/obo/DOID_0060155 visual agnosia http://purl.obolibrary.org/obo/DOID_4090 agnosia An agnosia that is a loss of the ability to visually recognize objects. http://purl.obolibrary.org/obo/DOID_0060158 acquired metabolic disease http://purl.obolibrary.org/obo/DOID_0014667 disease of metabolism A disease of metabolism that has _material_basis_in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption. http://purl.obolibrary.org/obo/DOID_0060159 organic acidemia http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder An amino acid metabolic disorder that disrupts normal amino acid metabolism causing a building up of branched-chain amino acids. http://purl.obolibrary.org/obo/DOID_0060160 childhood spinal muscular atrophy http://purl.obolibrary.org/obo/DOID_12377 spinal muscular atrophy A spinal muscular atrophy that is associated with the survival of motor neuron protein in childhood. http://purl.obolibrary.org/obo/DOID_0060161 Kennedy's disease http://purl.obolibrary.org/obo/DOID_12377 spinal muscular atrophy A spinal muscular dystrophy that has_material_basis_in an X-linked recessive expansion of CAG triplet repeats (glutamine) in exon 1 of AR gene encoding the androgen receptor. http://purl.obolibrary.org/obo/DOID_0060162 dentatorubral-pallidoluysian atrophy http://purl.obolibrary.org/obo/DOID_1441 autosomal dominant cerebellar ataxia An autosomal dominant cerebellar ataxia that has_material_basis_in expansion of CAG triplet repeats (glutamine) encoding a polyglutamine tract in the atrophin-1 protein. http://purl.obolibrary.org/obo/DOID_0060163 body dysmorphic disorder http://purl.obolibrary.org/obo/DOID_4737 somatoform disorder A somatoform disorder that involves an excessive concern about and preoccupation with a perceived defect in his or her physical features (body image). http://purl.obolibrary.org/obo/DOID_0060164 pain disorder http://purl.obolibrary.org/obo/DOID_4737 somatoform disorder A somatoform disorder that involves chronic pain in one or more areas, and is thought to be caused by psychological stress. http://purl.obolibrary.org/obo/DOID_0060165 Kleine-Levin syndrome http://purl.obolibrary.org/obo/DOID_8619 recurrent hypersomnia A recurrent hypersomnia that is characterized by recurring periods of excessive amounts of sleep and altered behavior. http://purl.obolibrary.org/obo/DOID_0060168 histidinemia http://purl.obolibrary.org/obo/DOID_9265 histidine metabolism disease A histidine metabolism disease characterized by a deficiency of the enzyme histidase. http://purl.obolibrary.org/obo/DOID_0060169 benign familial infantile epilepsy http://purl.obolibrary.org/obo/DOID_0050703 infancy electroclinical syndrome An infancy electroclinical syndrome that is characterized by convulsions, with onset at age 3 to 12 months. http://purl.obolibrary.org/obo/DOID_0060172 juvenile absence epilepsy http://purl.obolibrary.org/obo/DOID_0050705 adolescence-adult electroclinical syndrome An adolescence-adult electroclinical syndrome statring between the age of ten to 17 years characterized by the occurrence of typical absence seizures. http://purl.obolibrary.org/obo/DOID_0060173 Timothy syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by cardiac, hand/foot, facial, and neurodevelopmental features. The two forms are type 1 (classic) and type 2, a rare form that has_material_basis_in mutations in a transcript variant of CACNA1C on chromosome 12p13.33. http://purl.obolibrary.org/obo/DOID_0060175 succinic semialdehyde dehydrogenase deficiency http://purl.obolibrary.org/obo/DOID_0060176 gamma-amino butyric acid metabolism disorder A gamma-amino butyric acid metabolism disorder that is characterized by a deficiency of succinic semialdehyde dehydrogenase resulting in elevated levels of gamma-hydroxybutyric acid. http://purl.obolibrary.org/obo/DOID_0060176 gamma-amino butyric acid metabolism disorder http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder An amino acid metabolic disorder characterized by impairment of the GABA catabolic pathway. http://purl.obolibrary.org/obo/DOID_0060177 homocarnosinosis http://purl.obolibrary.org/obo/DOID_936 brain disease A gamma-amino butyric acid metabolism disorder that is characterized by an excess of homocarnosine in the brain and has_material_basis_in a deficiency of serum carnosinase in its ability to hydrolyze homocarnosine. http://purl.obolibrary.org/obo/DOID_0060180 colitis http://purl.obolibrary.org/obo/DOID_0050589 inflammatory bowel disease An inflammatory bowel disease that involves inflammation located_in colon. http://purl.obolibrary.org/obo/DOID_0060220 physical urticaria http://purl.obolibrary.org/obo/DOID_1555 urticaria An urticaria induced by external physical influences. http://purl.obolibrary.org/obo/DOID_0060224 atrial fibrillation http://purl.obolibrary.org/obo/DOID_10273 heart conduction disease A heart conduction disease that is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular and has symptoms palpitations, weakness, fatigue, lightheadedness, dizziness, confusion, shortness of breath and chest pain. http://purl.obolibrary.org/obo/DOID_0060262 gallbladder disease http://purl.obolibrary.org/obo/DOID_77 gastrointestinal system disease A gastrointestinal system disease that is located_in the gallbladder. http://purl.obolibrary.org/obo/DOID_0060307 autosomal dominant non-syndromic intellectual disability http://purl.obolibrary.org/obo/DOID_0050889 non-syndromic intellectual disability A non-syndromic intellectual disability characterized by an autosomal dominant inheritance pattern. http://purl.obolibrary.org/obo/DOID_0060309 syndromic X-linked intellectual disability http://purl.obolibrary.org/obo/DOID_0050888 syndromic intellectual disability A syndromic intellectual characterized by an X-linked inheritance pattern. http://purl.obolibrary.org/obo/DOID_0060340 ciliopathy http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome associated with mutations encoding defective proteins, which result in either abnormal function formation or function of cilia. http://purl.obolibrary.org/obo/DOID_0060388 chromosomal deletion syndrome http://purl.obolibrary.org/obo/DOID_0080014 chromosomal disease A chromosomal disease that has_material_basis_in partial deletion of chromosomes. http://purl.obolibrary.org/obo/DOID_0060429 chromosomal duplication syndrome http://purl.obolibrary.org/obo/DOID_0080014 chromosomal disease A chromosomal disease that has_material_basis_in extra copies of a chromosomal region. http://purl.obolibrary.org/obo/DOID_0060441 epithelial-stromal TGFBI dystrophy http://purl.obolibrary.org/obo/DOID_2566 corneal dystrophy A corneal dystrophy that is characterized by abnormal deposition of proteins in the cornea and is caused by mutations in TGFBI gene of chromosome 5q. http://purl.obolibrary.org/obo/DOID_0060442 stromal dystrophy http://purl.obolibrary.org/obo/DOID_2566 corneal dystrophy A corneal dystrophy that affects the corneal stroma. http://purl.obolibrary.org/obo/DOID_0060443 corneal endothelial dystrophy http://purl.obolibrary.org/obo/DOID_2566 corneal dystrophy A corneal dystrophy that affects the corneal endothelium and/or the descemet membrane. http://purl.obolibrary.org/obo/DOID_0060496 respiratory allergy http://purl.obolibrary.org/obo/DOID_1205 allergic disease An allergic disease that is located_in the respiratory tract. http://purl.obolibrary.org/obo/DOID_0060502 gastrointestinal allergy http://purl.obolibrary.org/obo/DOID_1205 allergic disease An allergic disease that is located_in the gastrointestinal tract. http://purl.obolibrary.org/obo/DOID_0060503 fruit allergy http://purl.obolibrary.org/obo/DOID_3044 food allergy A food allergy triggered by a plant fruit product. http://purl.obolibrary.org/obo/DOID_0060564 spinal disease http://purl.obolibrary.org/obo/DOID_0080001 bone disease A bone disease that is located_in the spine. http://purl.obolibrary.org/obo/DOID_0060611 abdominal obesity-metabolic syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by abdominal obesity, blood lipid disorders, inflammation, insulin resistance or full-blown diabetes, and increased risk of developing cardiovascular disease. http://purl.obolibrary.org/obo/DOID_0060655 autosomal recessive congenital ichthyosis http://purl.obolibrary.org/obo/DOID_1697 ichthyosis An ichthyosis that is characterized by autosomal recessive inheritance and abnormal skin scaling over the whole body due to a defect in keratinization. http://purl.obolibrary.org/obo/DOID_0060668 anencephaly http://purl.obolibrary.org/obo/DOID_2490 congenital nervous system abnormality A congenital nervous system abnormality characterized by failure of the anterior neuropore to close resulting in partial or complete absence of the cranial vault accompanied by absence of overlying tissues, including the brain and cerebral hemispheres, skull and scalp. http://purl.obolibrary.org/obo/DOID_0060786 hypomyelinating leukodystrophy http://purl.obolibrary.org/obo/DOID_10579 leukodystrophy A leukodystrophy characterized by T2 hyperintensity and T1 iso- or hyperintensity of affected white matter in the central nervous system. http://purl.obolibrary.org/obo/DOID_0060858 hypotonia-cystinuria syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that has_material_basis_in homozygous deletion on chromosome 2p21 that disrupts the SLC3A1 and PREPL genes. The deletion ranges in size from 23.8 to 75.5 kb. Itis characterized_by neonatal and infantile hypotonia and failure to thrive, cystinuria type 1 and nephrolithiasis, growth retardation due to growth hormone deficiency, and minor facial dysmorphism. http://purl.obolibrary.org/obo/DOID_0060859 salmonellosis http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease caused by the bacteria of the genus Salmonella. It has sypmtoms diarrhea, fever, vomiting, and abdominal cramps 12 to 72 hours after infection. In most cases, the illness lasts four to seven days, and most people recover without treatment. http://purl.obolibrary.org/obo/DOID_0070003 blastoma http://purl.obolibrary.org/obo/DOID_0050687 cell type cancer A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from precursor cells called blast cells. http://purl.obolibrary.org/obo/DOID_0070004 myeloid neoplasm http://purl.obolibrary.org/obo/DOID_4960 bone marrow cancer A bone marrow cancer that is formed of any one of the bone marrow cells belonging to the granulocytic (neutrophil, eosinophil, basophil), monocytic/macrophage, erythroid, megakaryocytic and mast cell lineages. http://purl.obolibrary.org/obo/DOID_0080000 muscular disease http://purl.obolibrary.org/obo/DOID_17 musculoskeletal system disease A musculoskeletal system disease that affects the muscles. http://purl.obolibrary.org/obo/DOID_0080001 bone disease http://purl.obolibrary.org/obo/DOID_65 connective tissue disease A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function. http://purl.obolibrary.org/obo/DOID_0080005 bone remodeling disease http://purl.obolibrary.org/obo/DOID_0080001 bone disease A bone disease that results_in formation or resorption abnormalities located_in bone. http://purl.obolibrary.org/obo/DOID_0080006 bone development disease http://purl.obolibrary.org/obo/DOID_0080001 bone disease A bone disease that results_in abnormal growth and development located_in bone or located_in cartilage. http://purl.obolibrary.org/obo/DOID_0080007 bone deterioration disease http://purl.obolibrary.org/obo/DOID_0080010 bone structure disease A bone structure disease that results_in change or damage of structure located_in bone. http://purl.obolibrary.org/obo/DOID_0080008 ischemic bone disease http://purl.obolibrary.org/obo/DOID_0080001 bone disease A bone disease that results_in an interruption of blood supply located_in bone. http://purl.obolibrary.org/obo/DOID_0080009 X-linked dominant disease http://purl.obolibrary.org/obo/DOID_0050735 X-linked monogenic disease A X-linked monogenic disease that has_material_basis_in dominant inheritance. http://purl.obolibrary.org/obo/DOID_0080010 bone structure disease http://purl.obolibrary.org/obo/DOID_0060564 spinal disease A bone disease that has_material_basis_in an abnormality in the location or function of the skeletal structure. http://purl.obolibrary.org/obo/DOID_0080011 bone resorption disease http://purl.obolibrary.org/obo/DOID_0080005 bone remodeling disease A bone remodeling disease that results in an abnormal decrease of bone density or mass. http://purl.obolibrary.org/obo/DOID_0080012 X-linked recessive disease http://purl.obolibrary.org/obo/DOID_0050735 X-linked monogenic disease A X-linked monogenic disease that has_material_basis_in recessive inheritance. http://purl.obolibrary.org/obo/DOID_0080014 chromosomal disease http://purl.obolibrary.org/obo/DOID_630 genetic disease A genetic disease that has_material_basis_in extra, missing, or re-arranged chromosomes. http://purl.obolibrary.org/obo/DOID_0080015 physical disorder http://purl.obolibrary.org/obo/DOID_4 disease A disease that has_material_basis_in a genetic abnormality, error with embryonic development, infection or compromised intrauterine environment. http://purl.obolibrary.org/obo/DOID_0080016 spina bifida http://purl.obolibrary.org/obo/DOID_0080074 neural tube defect A neural tube defect that is characterized by incomplete closing of the spine and membranes around the spinal cord during early development. http://purl.obolibrary.org/obo/DOID_0080019 metaphyseal dysplasia http://purl.obolibrary.org/obo/DOID_2256 osteochondrodysplasia An osteochondrodysplasia that is characterized by abnormally broad ends of the arm and leg long bones resembling a boat oar or paddle due to enlargement of the spongy inner layer of bone. http://purl.obolibrary.org/obo/DOID_0080027 spondyloepimetaphyseal dysplasia http://purl.obolibrary.org/obo/DOID_2256 osteochondrodysplasia An osteochondrodysplasia that results_in abnormalities of bone growth located_in vertebral column, located_in epiphysis, located_in metaphysis. http://purl.obolibrary.org/obo/DOID_0080031 fibrous dysplasia http://purl.obolibrary.org/obo/DOID_0080005 bone remodeling disease A bone remodeling disease that results_in the destruction of normal bone and replacing it with fibrous bone tissue. http://purl.obolibrary.org/obo/DOID_0080033 craniometaphyseal dysplasia http://purl.obolibrary.org/obo/DOID_4254 osteosclerosis An osteosclerosis that is characterized by hyperostosis and sclerosis of the craniofacial bones associated with abnormal modeling of the metaphyses. http://purl.obolibrary.org/obo/DOID_0080036 SOST-related sclerosing bone dysplasia http://purl.obolibrary.org/obo/DOID_205 hyperostosis A hyperostosis that has_material_basis_in a mutation in the SOST gene which results_in overgrowth of endosteal bone producing dense and wide bones throughout the body especially located_in skull. http://purl.obolibrary.org/obo/DOID_0080038 pycnodysostosis http://purl.obolibrary.org/obo/DOID_2256 osteochondrodysplasia An osteochondrodysplasia that has_material_basis_in a mutation in the CTSK gene which results_in dwarfism, brittle bones, osteopetrosis, shortening of the distal phalanges. http://purl.obolibrary.org/obo/DOID_0080041 hypochondroplasia http://purl.obolibrary.org/obo/DOID_2256 osteochondrodysplasia An osteochondrodysplasia that has_material_basis_in mutation in the FGFR3 gene which affects ossification of cartilage and results_in short limb dwarfism. http://purl.obolibrary.org/obo/DOID_0080043 achondrogenesis http://purl.obolibrary.org/obo/DOID_2256 osteochondrodysplasia An osteochondrodysplasia that has_material_basis_in deficient endochondral ossification which results_in dwarfism, short-trunk, short-limbed, anascara, disaprportionately large cranium, and a narrow chest which leads to death in utero or during early neonatal period. http://purl.obolibrary.org/obo/DOID_0080045 Kniest dysplasia http://purl.obolibrary.org/obo/DOID_2256 osteochondrodysplasia An osteochondrodysplasia that has_material_basis_in a mutation in the COL2A1 gene which results_in dwarfism with a short trunk and limbs as well as vision and hearing problems. The disease has_symptom large joints, has_symptom wide set eyes, has_symptom round flat face. http://purl.obolibrary.org/obo/DOID_0080046 Stickler syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by a distinctive facial appearance, eye abnormalities, hearing loss, and joint problems. http://purl.obolibrary.org/obo/DOID_0080047 pseudoachondroplasia http://purl.obolibrary.org/obo/DOID_2256 osteochondrodysplasia An osteochondrodysplasia that has_material_basis_in mutations in the COMP gene which results_in short limb dwarfism. http://purl.obolibrary.org/obo/DOID_0080049 acromesomelic dysplasia http://purl.obolibrary.org/obo/DOID_2256 osteochondrodysplasia An osteochondrodysplasia that has_material_basis_in mesomelia and acromelia, which results_in short limb dwarfism. http://purl.obolibrary.org/obo/DOID_0080072 intestinal pseudo-obstruction http://purl.obolibrary.org/obo/DOID_5353 colonic disease A colonic disease that is characterized by bowel obstruction resulting from impairment of the muscle contractions that move food through the digestive tract. http://purl.obolibrary.org/obo/DOID_0080074 neural tube defect http://purl.obolibrary.org/obo/DOID_0080015 physical disorder A physical disorder characterized by incomplete closure of the neural tube. http://purl.obolibrary.org/obo/DOID_0080122 Alpers-Huttenlocher syndrome http://purl.obolibrary.org/obo/DOID_0050737 autosomal recessive disease A mitochondrial DNA depletion syndrome that is characterized by a clinical triad of psychomotor retardation, intractable epilepsy, and liver failure in infants and young children, and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the nuclear gene encoding mitochondrial DNA polymerase gamma on chromosome 15q26. http://purl.obolibrary.org/obo/DOID_0080126 mitochondrial DNA depletion syndrome 7 http://purl.obolibrary.org/obo/DOID_0050737 autosomal recessive disease A mitochondrial DNA depletion syndrome that is characterized by progressive ataxia, hypotonia, hyporeflexia, athetosis and sensory impairment and has_material_basis_in autosomal recessive homozygous or compound heterozygous mutation in the C10ORF2 gene, which encodes the twinkle and twinky proteins, on chromosome 10q24. http://purl.obolibrary.org/obo/DOID_0110731 neuronal ceroid lipofuscinosis 3 http://purl.obolibrary.org/obo/DOID_630 genetic disease A neuronal ceroid lipofuscinosis that is characterized by juvenile-onset of progressive dementia, seizures, and progressive visual failure and an ultrastructural pattern of lipopigment with a 'fingerprint' profile and has_material_basis_in homozygous or compound heterozygous mutation in the CLN3 gene on chromosome 16p11. http://purl.obolibrary.org/obo/DOID_0110734 neurodegeneration with brain iron accumulation http://purl.obolibrary.org/obo/DOID_1289 neurodegenerative disease A neurodegenerative disease characterized by progressive iron accumulation in the basal ganglia and other regions of the brain, resulting in extrapyramidal movements, such as parkinsonism and dystonia. http://purl.obolibrary.org/obo/DOID_100 intestinal infectious disease http://purl.obolibrary.org/obo/DOID_5295 intestinal disease An intestinal disease that involves intestinal infection that has_material_basis_in viruses, bacteria, fungi and parasites. http://purl.obolibrary.org/obo/DOID_10017 multiple endocrine neoplasia type 1 http://purl.obolibrary.org/obo/DOID_0050736 autosomal dominant disease A multiple endocrine neoplasia that has_material_basis_in a mutation in the MEN1 tumor suppressor gene and is characterized by over active endocrine glands frequently involving tumors of the parathyroid glands, the pituitary gland, and the pancreas. http://purl.obolibrary.org/obo/DOID_1002 endometritis http://purl.obolibrary.org/obo/DOID_1005 endometrial disease An endometrial disease that is characterized by inflammation of the endometrium. http://purl.obolibrary.org/obo/DOID_10021 duodenum cancer http://purl.obolibrary.org/obo/DOID_10154 small intestine cancer A small intestine cancer that is located_in the beginning section of the small intestine. http://purl.obolibrary.org/obo/DOID_10024 migraine with aura http://purl.obolibrary.org/obo/DOID_6364 migraine A migraine characterized by migraine headache which is preceded or accompanied by a transient focal neurological phenomenon. http://purl.obolibrary.org/obo/DOID_10027 tabes dorsalis http://purl.obolibrary.org/obo/DOID_9988 tertiary neurosyphilis A tertiary neurosyphilis that results in slow degeneration of the nerve cells and nerve fibers that carry sensory information to the brain. The infection has symptom intense, stabbing pain in the back and legs that recurs irregularly, has symptom gait ataxia, has symptom hyperesthesia, has symptom paresthesia, has symptom loss of bladder sensation leading to urine retention, has symptom erectile dysfunction. http://purl.obolibrary.org/obo/DOID_1003 pelvic inflammatory disease http://purl.obolibrary.org/obo/DOID_229 female reproductive system disease A female reproductive system disease that is characterized by an infection of the female reproductive organs. http://purl.obolibrary.org/obo/DOID_10034 eye accommodation disease http://purl.obolibrary.org/obo/DOID_5614 eye disease An eye disease that is characterized by decreased ability to change the optical power of the eye to maintain a clear image. http://purl.obolibrary.org/obo/DOID_10047 nodular malignant melanoma http://purl.obolibrary.org/obo/DOID_8923 skin melanoma A melanoma that is characterized as highly aggressive and manifests as a uniform blue-black, blue-red, or amelanotic nodule. http://purl.obolibrary.org/obo/DOID_1005 endometrial disease http://purl.obolibrary.org/obo/DOID_345 uterine disease A uterine disease that is located_in the endometrium. http://purl.obolibrary.org/obo/DOID_10074 hymenolepiasis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that involves infection of the bowel by Hymenolepis nana or Hymenolepis diminuta. The symptoms include diarrhea, gastrointestinal discomfort, itchy anus, poor appetite and weakness. http://purl.obolibrary.org/obo/DOID_10075 diphyllobothriasis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that involves parasitic infection caused by Diphyllobothrium latum through the consumption of raw or undercooked fish. The symptoms include abdominal discomfort, diarrhea, vomiting, weight loss and vitamin B12 deficiency with pernicious anemia. http://purl.obolibrary.org/obo/DOID_10079 cysticercosis http://purl.obolibrary.org/obo/DOID_5614 eye disease A taeniasis that results from ingestion of eggs or larvae of the Taenia solium tapeworm in undercooked pork or fecally contaminated food or water, which subsequently infect the central nervous system, heart, muscles, subcutaneous tissues, and eyes. Neurocysticercosis causes seizures, mental disturbances, focal neurologic deficits and intracerebral lesions. http://purl.obolibrary.org/obo/DOID_10080 sparganosis http://purl.obolibrary.org/obo/DOID_936 brain disease A parasitic helminthiasis infectious disease that involves parasitic infection by the genus Spirometra. A painful nodule develops after the plerocercoid larvae migrate to the brain causing cerebral sparganosis. Subcutaneous tissue, breast, orbit, urinary tract, pleural cavity, lungs, abdominal viscera and inner ear can be infected. http://purl.obolibrary.org/obo/DOID_10095 intracranial abscess http://purl.obolibrary.org/obo/DOID_331 central nervous system disease A central nervous system disease that is located_in the skull and is characterized by a collection of pus (infected material) inside the skull. http://purl.obolibrary.org/obo/DOID_10112 sleeping sickness http://purl.obolibrary.org/obo/DOID_10113 trypanosomiasis A trypanosomiasis that results from infection by Trypanosoma brucei and gambiense, which is transmitted by the bite of an infected tsetse fly (Glossina spp). The symptoms include fever, headache, joint pain, itching, confusion, sensory disturbances, poor coordination and sleep disturbances. http://purl.obolibrary.org/obo/DOID_10113 trypanosomiasis http://purl.obolibrary.org/obo/DOID_2789 parasitic protozoa infectious disease A parasitic protozoa infectious disease that involves infection caused by parasitic protozoan of the genus Trypanosoma in animals and humans. http://purl.obolibrary.org/obo/DOID_10123 pigmentation disease http://purl.obolibrary.org/obo/DOID_37 skin disease A skin disease that is characterized by discoloration of the skin. http://purl.obolibrary.org/obo/DOID_10124 corneal disease http://purl.obolibrary.org/obo/DOID_5614 eye disease An eye disease that affects the cornea, which is the transparent surface of the eye that assists in light refraction. http://purl.obolibrary.org/obo/DOID_10126 keratoconus http://purl.obolibrary.org/obo/DOID_10124 corneal disease A corneal disease characterized by structural changes within the cornea causing it to thin and change, leading to a protruding conical shape. http://purl.obolibrary.org/obo/DOID_10128 venous insufficiency http://purl.obolibrary.org/obo/DOID_866 vein disease A vein disease that is characterized by impaired flow of blood through the veins. http://purl.obolibrary.org/obo/DOID_10140 dry eye syndrome http://purl.obolibrary.org/obo/DOID_1400 lacrimal apparatus disease A lacrimal apparatus disease that is characterized by persistent irritation or burning of the coreneal surface. http://purl.obolibrary.org/obo/DOID_10154 small intestine cancer http://purl.obolibrary.org/obo/DOID_10155 intestinal cancer An intestinal cancer that is located_in the small intestine. http://purl.obolibrary.org/obo/DOID_10155 intestinal cancer http://purl.obolibrary.org/obo/DOID_5295 intestinal disease A gastrointestinal system cancer that is located_in the intestine. http://purl.obolibrary.org/obo/DOID_10159 osteonecrosis http://purl.obolibrary.org/obo/DOID_0080008 ischemic bone disease An ischemic bone disease that results_in necrosis located_in bone. http://purl.obolibrary.org/obo/DOID_10188 skin lipoma http://purl.obolibrary.org/obo/DOID_3315 lipoma A skin benign neoplasm that derives_from fat cells. http://purl.obolibrary.org/obo/DOID_1019 osteomyelitis http://purl.obolibrary.org/obo/DOID_3342 bone inflammation disease A bone inflammation disease that has_material_basis_in infection located_in bone or located_in bone marrow. http://purl.obolibrary.org/obo/DOID_10199 breast lipoma http://purl.obolibrary.org/obo/DOID_3315 lipoma A breast benign neoplasm that is composed of lipocytes. http://purl.obolibrary.org/obo/DOID_10223 dermatomyositis http://purl.obolibrary.org/obo/DOID_633 myositis A myositis that results_in inflammation located_in muscle or located_in skin where a skin rash is often seen prior to the onset of muscle weakness. The disease may result from either a viral infection or an autoimmune reaction. http://purl.obolibrary.org/obo/DOID_1024 leprosy http://purl.obolibrary.org/obo/DOID_974 upper respiratory tract disease A primary bacterial infectious disease that results_in infection located_in superficial peripheral nerves, located_in skin, located_in mucous membranes of the upper respiratory tract, located_in anterior chamber of the eyes, or located_in testes, has_material_basis_in Mycobacterium leprae, which is transmitted_by aerosol spread from infected nasal secretions to exposed nasal and oral mucosa. The infection has_symptom skin lesions, has_symptom sensory loss, has_symptom motor loss and has_symptom eye damage. http://purl.obolibrary.org/obo/DOID_10241 thalassemia http://purl.obolibrary.org/obo/DOID_583 hemolytic anemia A hemolytic anemia characterized by decreased synthesis of one or more hemoglobin polypeptide chains. http://purl.obolibrary.org/obo/DOID_10242 ehrlichiosis http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that results in infection located_in leukocyte, has_material_basis_in Ehrlichia chaffeensis or Anaplasma phagocytophilum, which are transmitted_by lone start stick and transmitted_by black-legged tick respectively. The infection has_symptom headache, has_symptom muscle aches, has_symptom fatigue and has_symptom rash. http://purl.obolibrary.org/obo/DOID_10247 pleurisy http://purl.obolibrary.org/obo/DOID_1532 pleural disease A pleural disease that is characterized by inflammation of the pleura, the lining of the pleural cavity surrounding the lungs. http://purl.obolibrary.org/obo/DOID_10250 louping ill http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results in infection in sheep and rarely humans, has_material_basis_in Louping ill virus, which is transmitted by sheep tick, Ixodes ricinus. The infection has symptom lethargy, has symptom muscle pains, has symptom fever, and has symptom focal neurological signs. http://purl.obolibrary.org/obo/DOID_10264 mumps http://purl.obolibrary.org/obo/DOID_10883 herpangina A viral infectious disease that results in inflammation located in salivary gland, has_material_basis_in Mumps rubulavirus, which is transmitted by droplet spread of saliva or mucus from the mouth, nose, or throat of an infected person, or transmitted by contaminated fomites. The infection has symptom fever, has symptom headache, has symptom muscle aches, has symptom tiredness, has symptom loss of appetite, has symptom swollen and tender salivary glands under the ears or jaw on one or both sides of the face. http://purl.obolibrary.org/obo/DOID_10273 heart conduction disease http://purl.obolibrary.org/obo/DOID_114 heart disease A cardiovascular system disease that involves the heart's electrical conduction system. http://purl.obolibrary.org/obo/DOID_10283 prostate cancer http://purl.obolibrary.org/obo/DOID_47 prostate disease A male reproductive organ cancer that is located_in the prostate. http://purl.obolibrary.org/obo/DOID_10301 parotitis http://purl.obolibrary.org/obo/DOID_10302 parotid disease A parotid disease characterized by the inflammation of one or both parotid glands. http://purl.obolibrary.org/obo/DOID_10314 endocarditis http://purl.obolibrary.org/obo/DOID_0050825 endocardium disease A endocardium disease characterized by inflammation of the endocardium of the heart chambers and valves. http://purl.obolibrary.org/obo/DOID_10316 pneumoconiosis http://purl.obolibrary.org/obo/DOID_3082 interstitial lung disease An interstitial lung disease that is caused by the inhalation of dust. http://purl.obolibrary.org/obo/DOID_10320 asbestosis http://purl.obolibrary.org/obo/DOID_10316 pneumoconiosis A pneumoconiosis caused by inhalation and retention of asbestos fibers. http://purl.obolibrary.org/obo/DOID_10325 silicosis http://purl.obolibrary.org/obo/DOID_10316 pneumoconiosis A pneumoconiosis that is an inflammation and scarring of the uper lobes of the lungs causing nodular lesions resulting from inhalation of silica, quartz or slate particles. http://purl.obolibrary.org/obo/DOID_10350 breast cyst http://purl.obolibrary.org/obo/DOID_0060082 breast benign neoplasm A breast benign neoplasm that is characterized by a fluid-filled sac. http://purl.obolibrary.org/obo/DOID_1037 lymphoid leukemia http://purl.obolibrary.org/obo/DOID_1240 leukemia A leukemia that has_material_basis_in a B-cell or T-cell lineage involving primarily the bone marrow and the peripheral blood. http://purl.obolibrary.org/obo/DOID_10371 yaws http://purl.obolibrary.org/obo/DOID_37 skin disease A primary bacterial infectious disease that results in infection located in skin, located in joint or located in bone, has_material_basis_in Treponema pallidum subsp pertenue, which is transmitted by direct skin contact with an infected person. The infection has symptom skin lesions. http://purl.obolibrary.org/obo/DOID_10376 amblyopia http://purl.obolibrary.org/obo/DOID_5614 eye disease An eye disease that is characterized by poor vision in one eye resulting from the brain failing to process inputs from one eye and over time favors the other eye. http://purl.obolibrary.org/obo/DOID_10398 pneumonic plague http://purl.obolibrary.org/obo/DOID_850 lung disease A plague that results_in infection located_in lung, which results from direct inhalation of the bacillus and has_symptom fever, has_symptom chills, has_symptom cough and has_symptom difficulty breathing. http://purl.obolibrary.org/obo/DOID_104 bacterial infectious disease http://purl.obolibrary.org/obo/DOID_0050117 disease by infectious agent A disease by infectious agent that results_in infection, has_material_basis_in Bacteria. http://purl.obolibrary.org/obo/DOID_1040 chronic lymphocytic leukemia http://purl.obolibrary.org/obo/DOID_1037 lymphoid leukemia A lymphocytic leukemia characterized by over production of B-cells and their accumulation in bone marrow and blood. http://purl.obolibrary.org/obo/DOID_10426 Klippel-Feil syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A physical disorder that is characterized by abnormal segmentation of the vertebra during fetal development which results in fusion located in cervical vertebra. http://purl.obolibrary.org/obo/DOID_10439 Mooren's ulcer http://purl.obolibrary.org/obo/DOID_8463 corneal ulcer A corneal ulcer that is characterized by painful peripheral corneal ulceration, sterile limbal inflammation, and episcleral and conjunctival edema. http://purl.obolibrary.org/obo/DOID_10456 tonsillitis http://purl.obolibrary.org/obo/DOID_974 upper respiratory tract disease An upper respiratory tract disease which is characterized by inflammation of the tonsils resulting from bacterial (Group A streptococcus) and viral (Epstein-Barr virus, adenovirus) infections. Symptoms include a severe sore throat, painful or difficult swallowing, coughing, headache, myalgia, fever and chills. http://purl.obolibrary.org/obo/DOID_10457 Legionnaires' disease http://purl.obolibrary.org/obo/DOID_10458 legionellosis A legionellosis that is characterized by severe form of infection producing pneumonia. Symptoms include fever, chills, and cough. http://purl.obolibrary.org/obo/DOID_10458 legionellosis http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that results_in infection located_in respiratory tract, has_material_basis_in Legionella pneumophila, which is transmitted_by inhalation of droplets containing bacteria. The symptoms include dry cough, fever, headache and diarrhea. http://purl.obolibrary.org/obo/DOID_10459 common cold http://purl.obolibrary.org/obo/DOID_974 upper respiratory tract disease An upper respiratory tract disease which involves inflammation of the mucous membranes of the nose, throat, eyes, and eustachian tubes with watery then purulent discharge. This is an acute contagious disease caused by rhinoviruses, human parainfluenza viruses, human respiratory syncytial virus, influenza viruses, adenoviruses, enteroviruses, or metapneumovirus. http://purl.obolibrary.org/obo/DOID_10460 nasopharyngitis http://purl.obolibrary.org/obo/DOID_9561 nasopharyngeal disease A nasopharyngeal disease which involves inflammation of the nasal passages and upper part of the pharynx. http://purl.obolibrary.org/obo/DOID_10481 diaphragm disease http://purl.obolibrary.org/obo/DOID_0080000 muscular disease A muscular disease that is located_in the diaphragm. http://purl.obolibrary.org/obo/DOID_10487 Hirschsprung's disease http://purl.obolibrary.org/obo/DOID_11372 megacolon A megacolon that is characterized by a blockage of the large intestine due to improper muscle movement in the bowel. http://purl.obolibrary.org/obo/DOID_10533 viral pneumonia http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A pneumonia described as an inflammatory illness of the lung commonly caused by viruses such as influenza virus, parainfluenza, adenovirus, rhinovirus, herpes simplex virus, respiratory syncytial virus, hantavirus, and cytomegalovirus. http://purl.obolibrary.org/obo/DOID_10534 stomach cancer http://purl.obolibrary.org/obo/DOID_76 stomach disease A gastrointestinal system cancer that is located_in the stomach. http://purl.obolibrary.org/obo/DOID_10554 meningoencephalitis http://purl.obolibrary.org/obo/DOID_331 central nervous system disease A central nervous system disease that involves encephalitis which occurs along with meningitis. http://purl.obolibrary.org/obo/DOID_1056 oculocerebrorenal syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that has_material_basis_in mutation in the OCRL gene on chromosome Xq26 and that is characterized by hydrophthalmia, cataract, mental retardation, vitamin D-resistant rickets, amino aciduria, and reduced ammonia production by the kidney. http://purl.obolibrary.org/obo/DOID_10573 osteomalacia http://purl.obolibrary.org/obo/DOID_0080005 bone remodeling disease A bone remodeling disease that has_material_basis_in a vitamin D deficiency which results_in softening located_in bone. http://purl.obolibrary.org/obo/DOID_10579 leukodystrophy http://purl.obolibrary.org/obo/DOID_1443 cerebral degeneration A cerebral degeneration characterized by dysfunction of the white matter of the brain. http://purl.obolibrary.org/obo/DOID_10581 metachromatic leukodystrophy http://purl.obolibrary.org/obo/DOID_1927 sphingolipidosis A sphingolipidosis characterized by the accumulation of sulfatides in cells, especially the myelin producing cells of the nervous system. http://purl.obolibrary.org/obo/DOID_10584 retinitis pigmentosa http://purl.obolibrary.org/obo/DOID_8466 retinal degeneration A retinal degeneration characterized by the gradual deterioration of the photoreceptors or the retinal pigment epithelium of the retina leading to progressive sight loss. http://purl.obolibrary.org/obo/DOID_10588 adrenoleukodystrophy http://purl.obolibrary.org/obo/DOID_10579 leukodystrophy A leukodystrophy that disrupts the breakdown of very-long-chain fatty acids resulting in progressive brain damage, failure of the adrenal glands and eventually death. http://purl.obolibrary.org/obo/DOID_1059 intellectual disability http://purl.obolibrary.org/obo/DOID_0060038 specific developmental disorder A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills. http://purl.obolibrary.org/obo/DOID_10591 pre-eclampsia http://purl.obolibrary.org/obo/DOID_10763 hypertension A hypertension occurring during pregnancy characterized by large amounts of protein in the urine (proteinuria) and edema, usually by the last trimester of pregnancy. http://purl.obolibrary.org/obo/DOID_10595 Charcot-Marie-Tooth disease http://purl.obolibrary.org/obo/DOID_440 neuromuscular disease A neuromuscular disease that is characterized by a slowly progressive degeneration of the muscles of the foot, lower leg, hand and forearm. http://purl.obolibrary.org/obo/DOID_1060 Hartnup disease http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder An amino acid metabolic disorder that is caused by abnormalities of the renal tubules and is characterized especially by aminoaciduria involving only monocarboxylic monoamines, a dry red scaly rash, and episodic muscular incoordination due to the effects of the disease on the cerebellum. http://purl.obolibrary.org/obo/DOID_10600 chronic tic disorder http://purl.obolibrary.org/obo/DOID_2769 tic disorder A tic disorder that is characterized by single or multiple motor or phonic tics, but not both, which are present for more than a year. http://purl.obolibrary.org/obo/DOID_10605 short bowel syndrome http://purl.obolibrary.org/obo/DOID_5295 intestinal disease An intestinal disease that is characterized by a reduced ability to absorb nutrients due to the physical loss or the loss of function of a portion of the small and/or large intestine. http://purl.obolibrary.org/obo/DOID_10606 blind loop syndrome http://purl.obolibrary.org/obo/DOID_5295 intestinal disease An intestinal disease characterized by a dysbalance of the bacterial flora of the small intestine, causing derangement to the normal physiological processes of digestion and absorption. http://purl.obolibrary.org/obo/DOID_10608 celiac disease http://purl.obolibrary.org/obo/DOID_0060031 autoimmune disease of gastrointestinal tract An autoimmune disease of gastrointestinal tract that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite. http://purl.obolibrary.org/obo/DOID_10609 rickets http://purl.obolibrary.org/obo/DOID_0080005 bone remodeling disease A bone remodeling disease that has_material_basis_in impaired mineralization or calcification of bones before epiphyseal closure due to deficiency or impaired metabolism of vitamin D, phosphorus or calcium which results_in softening and deformity located_in bone. http://purl.obolibrary.org/obo/DOID_10612 allergic urticaria http://purl.obolibrary.org/obo/DOID_1555 urticaria An urticaria that is characterized by erythematous papules and plaques, has_symptom pruritis, and has_material_basis_in allergic reaction. http://purl.obolibrary.org/obo/DOID_1062 Fanconi syndrome http://purl.obolibrary.org/obo/DOID_447 renal tubular transport disease A renal tubular transport disease of the proximal renal tubes characterized by glucosuria, phosphaturia, generalized aminoaciduria and HCO3 wasting. http://purl.obolibrary.org/obo/DOID_10629 microphthalmia http://purl.obolibrary.org/obo/DOID_5614 eye disease An eye disease where one or both eyeballs are abnormally small. http://purl.obolibrary.org/obo/DOID_10632 Wolfram syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by diabetes mellitus, optic atrophy, and deafness. http://purl.obolibrary.org/obo/DOID_1064 cystinosis http://purl.obolibrary.org/obo/DOID_3211 lysosomal storage disease A lysosomal storage disease characterized by the abnormal accumulation of cystine in the lysosomes. It follows an autosomal recessive inheritance pattern and that has_material_basis_in mutations in the CTNS gene, located on chromosome 17. http://purl.obolibrary.org/obo/DOID_10646 schizotypal personality disorder http://purl.obolibrary.org/obo/DOID_1510 personality disorder A personality disorder that involves a need for social isolation, anxiety in social situations, odd behavior and thinking, and often unconventional beliefs. http://purl.obolibrary.org/obo/DOID_10652 Alzheimer's disease http://purl.obolibrary.org/obo/DOID_680 tauopathy A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. http://purl.obolibrary.org/obo/DOID_1067 open-angle glaucoma http://purl.obolibrary.org/obo/DOID_1686 glaucoma A glaucoma characterized by optic nerve damage resulting in progressive loss of visual field and increased pressure in the eye due to trabecular blockage. http://purl.obolibrary.org/obo/DOID_10690 mastitis http://purl.obolibrary.org/obo/DOID_3463 breast disease A breast disease characterized by painful infection of the breast tissue. http://purl.obolibrary.org/obo/DOID_10699 paragonimiasis http://purl.obolibrary.org/obo/DOID_936 brain disease A parasitic helminthiasis infectious disease that involves parasitic infection by flukes of the genus Paragonimus. In the acute phase, the symptoms are diarrhea, abdominal pain, fever, cough, urticaria, hepatosplenomegaly, pulmonary abnormalities, and eosinophilia. Pulmonary manifestations include cough, expectoration of discolored sputum, hemoptysis, and chest radiographic abnormalities. Various organs like brain, spleen and liver can be infected. http://purl.obolibrary.org/obo/DOID_1070 primary open angle glaucoma http://purl.obolibrary.org/obo/DOID_1067 open-angle glaucoma An open-angle glaucoma that is characterized by the absence of any apparent obstruction of aqueous outflow through the trabecular meshwork with gonioscopy, but often with elevated intraocular pressure. http://purl.obolibrary.org/obo/DOID_10718 giardiasis http://purl.obolibrary.org/obo/DOID_2789 parasitic protozoa infectious disease A parasitic protozoa infectious disease that involves infection of the small intestine by a single-celled enteric protozoan parasite Giardia intestinalis. The symptoms include greasy and malodorous stools, diarrhea, abdominal pain, bloating, nausea, and vomiting. http://purl.obolibrary.org/obo/DOID_1074 kidney failure http://purl.obolibrary.org/obo/DOID_557 kidney disease A kidney disease characterized by the failure of the kidneys to adequately filter waste products from the blood. http://purl.obolibrary.org/obo/DOID_10754 otitis media http://purl.obolibrary.org/obo/DOID_5100 middle ear disease A otitis which involves inflammation of the middle ear. http://purl.obolibrary.org/obo/DOID_10763 hypertension http://purl.obolibrary.org/obo/DOID_0050828 artery disease An artery disease characterized by chronic elevated blood pressure in the arteries. http://purl.obolibrary.org/obo/DOID_10784 Queensland tick typhus http://purl.obolibrary.org/obo/DOID_11104 spotted fever A spotted fever that has_material_basis_in Rickettsia australis, which is transmitted_by ticks (Ixodes holocyclus). The infection has_symptom fever, has_symptom headache, has_symptom myalgia, has_symptom maculopapular rash, and has_symptom lymphadenopathy. http://purl.obolibrary.org/obo/DOID_10791 frontal sinusitis http://purl.obolibrary.org/obo/DOID_0050127 sinusitis A sinusitis which involves infection of the frontal sinuses over the eyes in the brow area. This causes pain or pressure in the frontal sinus cavity and headache over the forehead. http://purl.obolibrary.org/obo/DOID_10792 chronic maxillary sinusitis http://purl.obolibrary.org/obo/DOID_2051 maxillary sinusitis A maxillary sinusitis which lasts for 12 weeks or more. http://purl.obolibrary.org/obo/DOID_10794 sphenoid sinusitis http://purl.obolibrary.org/obo/DOID_0050127 sinusitis A sinusitis which involves infection of sphenoid sinuses that causes pain or pressure behind the eyes, but often refers to the vertex of the head. http://purl.obolibrary.org/obo/DOID_1080 filariasis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that involves parasitic infection of the lymphatics and subcutaneous tissue by nematodes of the superfamily Filarioidea. http://purl.obolibrary.org/obo/DOID_10811 nasal cavity cancer http://purl.obolibrary.org/obo/DOID_2163 nasal cavity disease A respiratory system cancer that is located_in the nasal cavity. http://purl.obolibrary.org/obo/DOID_10816 duodenum adenocarcinoma http://purl.obolibrary.org/obo/DOID_299 adenocarcinoma A duodenum cancer that derives_from epithelial cells of glandular origin. http://purl.obolibrary.org/obo/DOID_1082 dirofilariasis http://purl.obolibrary.org/obo/DOID_850 lung disease A filariasis that is a zoonotic infection caused by nematodes Dirofilaria immitis or Dirofilaria repens, which are transmitted to humans from dogs, cats, wolves and coyotes by infected mosquitoes. The disease manifests as either subcutaneous nodules or pulmonary lesions. http://purl.obolibrary.org/obo/DOID_10841 Eastern equine encephalitis http://purl.obolibrary.org/obo/DOID_936 brain disease A viral infectious disease that results in inflammation located in brain of horses and humans, has_material_basis_in Eastern equine encephalitis virus, which is transmitted by Aedes, transmitted by Coquillettidia, and transmitted by Culex species of mosquitoes. The infection has symptom sudden onset of headache, has symptom high fever, has symptom chills, has symptom vomiting, has symptom disorientation, has symptom seizures, and has symptom coma. http://purl.obolibrary.org/obo/DOID_10842 Murray Valley encephalitis http://purl.obolibrary.org/obo/DOID_936 brain disease A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in Murray Valley encephalitis virus, which is transmitted_by Culex annulirostris mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom drowsiness, has_symptom confusion, has_symptom fitting, and has_symptom weakness. http://purl.obolibrary.org/obo/DOID_10843 Western equine encephalitis http://purl.obolibrary.org/obo/DOID_936 brain disease A viral infectious disease that results_in inflammation located_in brain of horses and humans, has_material_basis_in Western equine encephalomyelitis virus, which is transmitted_by Culex and transmitted_by Aedes species of mosquitoes. The infection has_symptom fever, has_symptom headache, has_symptom nausea, has_symptom vomiting, has_symptom anorexia, has_symptom malaise, has_symptom altered mental status, and has_symptom weakness. http://purl.obolibrary.org/obo/DOID_10844 Japanese encephalitis http://purl.obolibrary.org/obo/DOID_936 brain disease A viral infectious disease that results_in infection located_in brain, has_material_basis_in Japanese encephalitis virus, which is transmitted_by Culex tritaeniorhynchus mosquito bite. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, and has_symptom spastic paralysis. http://purl.obolibrary.org/obo/DOID_10845 St. Louis encephalitis http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in inflammation located_in brain, has_material_basis_in St. Louis encephalitis virus, which is transmitted_by Culex mosquitoes. The infection has_symptom headache, has_symptom high fever, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions and has_symptom spastic paralysis. http://purl.obolibrary.org/obo/DOID_1085 Edwards syndrome http://purl.obolibrary.org/obo/DOID_0060429 chromosomal duplication syndrome A chromosomal duplciation syndrome that is characterized by slow growth before birth and a low birth weight and that has_material_basis_in three copies of chromosome 18. http://purl.obolibrary.org/obo/DOID_10854 salivary gland disease http://purl.obolibrary.org/obo/DOID_403 mouth disease A mouth disease located_in the salivary gland. http://purl.obolibrary.org/obo/DOID_10871 age related macular degeneration http://purl.obolibrary.org/obo/DOID_2007 degeneration of macula and posterior pole A degeneration of macula and posterior pole that is characterized by a loss of vision in the center of the visual field (the macula) resulting from damage to the retina and resulting in blurring of the sharp central vision. http://purl.obolibrary.org/obo/DOID_1088 meningocele http://purl.obolibrary.org/obo/DOID_0080016 spina bifida A spina bifida that is characterized by herniation of the meninges between the vertebrae. http://purl.obolibrary.org/obo/DOID_10881 hand, foot and mouth disease http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in infection located_in skin, has_material_basis_in Human coxsackievirus A16 or has_material_basis_in Human enterovirus 71, which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has_symptom fever, has_symptom poor appetite, has_symptom malaise, has_symptom sore throat, has_symptom painful sores in the mouth, and has_symptom skin rash on the palms of the hands and soles of the feet. http://purl.obolibrary.org/obo/DOID_10882 epidemic pleurodynia http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results in necrosis located in intercostal muscle, has_material_basis_in Human enterovirus B. The infection has symptom severe chest pain, has symptom fever, has symptom malaise, has symptom pleuritis, and has symptom headache. http://purl.obolibrary.org/obo/DOID_10883 herpangina http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results in infection located in mouth, has_material_basis_in Human coxsackievirus A16, has_material_basis_in Human enterovirus 71, has_material_basis_in group B coxsackievirus, or has_material_basis_in echoviruses, which are transmitted by ingestion of food contaminated with feces, transmitted by contact with pharyngeal secretions, or transmitted by droplet spread of oronasal secretions. The infection has symptom fever, has symptom sore throat, and has symptom lesions in the back area of the mouth, particularly the soft palate or tonsillar pillars. http://purl.obolibrary.org/obo/DOID_10892 hypospadias http://purl.obolibrary.org/obo/DOID_0080015 physical disorder A physical disorder characterized by an abnormally placed urethral opening on the underside of the penis or on the perineum. http://purl.obolibrary.org/obo/DOID_10907 microcephaly http://purl.obolibrary.org/obo/DOID_2490 congenital nervous system abnormality A congenital nervous system abnormality that is characterized by a significantly smaller than normal head in infants. http://purl.obolibrary.org/obo/DOID_10908 hydrocephalus http://purl.obolibrary.org/obo/DOID_1443 cerebral degeneration A cerebral degeneration characterized by an abnormal accumulation of cerebrospinal fluid in the ventricles of the brain, leading to progressive enlargement of the head. http://purl.obolibrary.org/obo/DOID_1091 tooth disease http://purl.obolibrary.org/obo/DOID_403 mouth disease A mouth disease located_in the teeth. http://purl.obolibrary.org/obo/DOID_10914 amnestic disorder http://purl.obolibrary.org/obo/DOID_1561 cognitive disorder A cognitive disorder where the memory is disturbed or lost and involves the loss of memories previously established, loss of the ability to create new memories, or loss of the ability to learn new information. http://purl.obolibrary.org/obo/DOID_10915 Wernicke-Korsakoff syndrome http://purl.obolibrary.org/obo/DOID_0070313 thiamine deficiency disease A nutritional deficiency disease that is characterized by ophthalmoplegia, ataxia, change in mental status and acute onset of severe memory impairment without any dysfunction in intellectual abilities, and has_material_basis_in thiamine deficiency. http://purl.obolibrary.org/obo/DOID_10919 transsexualism http://purl.obolibrary.org/obo/DOID_1234 gender identity disorder A gender identity disorder that is characterized by an individual's identification with a gender inconsistent or not culturally associated with their biological sex. http://purl.obolibrary.org/obo/DOID_10923 sickle cell anemia http://purl.obolibrary.org/obo/DOID_620 blood protein disease A blood protein disease that is characterized by low number of red blood cells, repeated infections, and periodic episodes of pain, resulting from atypical hemoglobin molecules called hemoglobin S, which can distort red blood cells into a sickle, or crescent, shape. http://purl.obolibrary.org/obo/DOID_10930 borderline personality disorder http://purl.obolibrary.org/obo/DOID_1510 personality disorder A personality disorder that involves a prolonged disturbance of personality function characterized by depth and variability of moods. http://purl.obolibrary.org/obo/DOID_10931 dependent personality disorder http://purl.obolibrary.org/obo/DOID_1510 personality disorder A personality disorder that is characterized by a pervasive psychological dependence on other people. http://purl.obolibrary.org/obo/DOID_10932 obsessive-compulsive personality disorder http://purl.obolibrary.org/obo/DOID_1510 personality disorder A personality disorder that is characterized by a pervasive pattern of preoccupation with orderliness, perfectionism, and mental and interpersonal control at the expense of flexibility, openness, and efficiency. http://purl.obolibrary.org/obo/DOID_10934 multiple personality disorder http://purl.obolibrary.org/obo/DOID_10935 dissociative disorder A dissociative disorder that involves the simultaneous display of multiple distinct identities or personalities. http://purl.obolibrary.org/obo/DOID_10935 dissociative disorder http://purl.obolibrary.org/obo/DOID_150 disease of mental health A disease of mental health in which the normally well-integrated functions of memory, identity, perception, or consciousness are separated (dissociated). http://purl.obolibrary.org/obo/DOID_10936 schizoid personality disorder http://purl.obolibrary.org/obo/DOID_1510 personality disorder A personality disorder that is characterized by a lack of interest in social relationships, a tendency towards a solitary lifestyle, secretiveness, emotional coldness and sometimes sexual apathy, with a simultaneous rich, elaborate and exclusively internal fantasy world. http://purl.obolibrary.org/obo/DOID_10937 impulse control disorder http://purl.obolibrary.org/obo/DOID_150 disease of mental health A disease of mental health that involves a failure to resist an impulsive act or behaviour that may be harmful to self or others. http://purl.obolibrary.org/obo/DOID_10938 paranoid personality disorder http://purl.obolibrary.org/obo/DOID_1510 personality disorder A personality disorder that is characterized by paranoia and a pervasive, long-standing suspiciousness and generalized mistrust of others. http://purl.obolibrary.org/obo/DOID_10939 antisocial personality disorder http://purl.obolibrary.org/obo/DOID_1510 personality disorder A personality disorder that involves a pervasive pattern of disregard for, and violation of, the rights of others that begins in childhood or early adolescence and continues into adulthood. http://purl.obolibrary.org/obo/DOID_1094 attention deficit hyperactivity disorder http://purl.obolibrary.org/obo/DOID_0060038 specific developmental disorder A specific developmental disorder that is characterized by co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone and symptoms starting before seven years of age. http://purl.obolibrary.org/obo/DOID_10944 tongue disease http://purl.obolibrary.org/obo/DOID_403 mouth disease A mouth disease located_in the tongue. http://purl.obolibrary.org/obo/DOID_10952 nephritis http://purl.obolibrary.org/obo/DOID_557 kidney disease A kidney disease that is characterized by an inflammation of the kidneys. http://purl.obolibrary.org/obo/DOID_10955 strongyloidiasis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that involves infection of the intestine, lungs, skin and central nervous system with nematode Strongyloides stercoralis. http://purl.obolibrary.org/obo/DOID_10965 spastic diplegia http://purl.obolibrary.org/obo/DOID_0050669 spastic cerebral palsy A spastic cerebral palsy that affects lower extremities resulting in tight leg and hip muscles. The legs cross at the knees, making it difficult to walk. http://purl.obolibrary.org/obo/DOID_10967 spastic hemiplegia http://purl.obolibrary.org/obo/DOID_0050669 spastic cerebral palsy A spastic cerebral palsy that affects one side of the body resulting in stiff arm, hand and leg. On the affected side,the arm and leg may not develop normally. http://purl.obolibrary.org/obo/DOID_10969 hemiplegia http://purl.obolibrary.org/obo/DOID_331 central nervous system disease A central nervous system disease that is characterized by the complete paralysis of half of the body. http://purl.obolibrary.org/obo/DOID_10970 spastic quadriplegia http://purl.obolibrary.org/obo/DOID_0050669 spastic cerebral palsy A spastic cerebral palsy that affects all four limbs. The individuals have difficulty with walking and talking. http://purl.obolibrary.org/obo/DOID_10974 oophoritis http://purl.obolibrary.org/obo/DOID_1100 ovarian disease An ovarian disease that is characterized by inflammation of the ovary. http://purl.obolibrary.org/obo/DOID_10983 Alport syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome disease that is characterized by glomerulonephritis, endstage kidney disease, and hearing loss. http://purl.obolibrary.org/obo/DOID_1099 alpha thalassemia http://purl.obolibrary.org/obo/DOID_10241 thalassemia Alpha thalassemia is a thalassemia involving the genes HBA1and HBA2 hemoglobin genes. http://purl.obolibrary.org/obo/DOID_10992 acute hemorrhagic leukoencephalitis http://purl.obolibrary.org/obo/DOID_639 acute disseminated encephalomyelitis A very rare form of acute disseminated encephalomyelitis, characterized by a brief but intense attack of inflammation and necrotizing vasculitis of venules and hemorrhage, and edema. http://purl.obolibrary.org/obo/DOID_110 lens disease http://purl.obolibrary.org/obo/DOID_5614 eye disease An eye disease that affects the lens of the eye, which is the transparent disc that focuses light to the photosensors in the back of the eye. http://purl.obolibrary.org/obo/DOID_1100 ovarian disease http://purl.obolibrary.org/obo/DOID_229 female reproductive system disease A female reproductive system disease that is located_in the ovary. http://purl.obolibrary.org/obo/DOID_11037 dissociative amnesia http://purl.obolibrary.org/obo/DOID_10935 dissociative disorder A dissociative disorder where he continuity of the patient's memory is disrupted. Patients with dissociative amnesia have recurrent episodes in which they forget important personal information or events, usually connected with trauma or severe stress. http://purl.obolibrary.org/obo/DOID_11038 depersonalization disorder http://purl.obolibrary.org/obo/DOID_10935 dissociative disorder A dissociative disorder in which the sufferer is affected by persistent or recurrent feelings of depersonalization and/or derealization. http://purl.obolibrary.org/obo/DOID_11042 Felty's syndrome http://purl.obolibrary.org/obo/DOID_417 autoimmune disease A syndrome that results_in rheumatoid arthritis, splenomegaly and neutropenia. http://purl.obolibrary.org/obo/DOID_11049 meconium aspiration syndrome http://purl.obolibrary.org/obo/DOID_850 lung disease A lung disease that is characterized by a newborn breathing in a mixture of meconium and amniotic fluid into the lungs around the time of delivery. http://purl.obolibrary.org/obo/DOID_11054 urinary bladder cancer http://purl.obolibrary.org/obo/DOID_3996 urinary system cancer An urinary system cancer that results_in malignant growth located_in the urinary bladder. http://purl.obolibrary.org/obo/DOID_11055 pasteurellosis http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Pasteurella multocida, which is transmitted_by animal bite, scratch, or lick. The infection has_symptom joint pain has_symptom fever, has_symptom rigors, has_symptom pneumonia, has_symptom meningeal irritation, and has_symptom tachycardia. http://purl.obolibrary.org/obo/DOID_11060 placenta praevia http://purl.obolibrary.org/obo/DOID_780 placenta disease A placenta disease that is characterized by placenta attachment to the uterine wall close to or covering the cervix. http://purl.obolibrary.org/obo/DOID_1107 esophageal carcinoma http://purl.obolibrary.org/obo/DOID_5041 esophageal cancer A esophageal cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. http://purl.obolibrary.org/obo/DOID_11077 brucellosis http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that is caused by the bacteria of the genus Brucella, when humans come in contact with contaminated animals or animal products or ingestion of infected food products. The disease has_symptom fever, has_symptom sweat, has_symptom headache, has_symptom back pain, has_symptom physical weakness, has_symptom joint pain and has_symptom fatigue. http://purl.obolibrary.org/obo/DOID_11080 myiasis http://purl.obolibrary.org/obo/DOID_4110 parasitic ectoparasitic infectious disease A parasitic ectoparasitic infectious disease that is caused by parasitic dipterous fly larvae (maggots) feeding on the host's necrotic or living tissue. http://purl.obolibrary.org/obo/DOID_11088 asphyxia neonatorum http://purl.obolibrary.org/obo/DOID_1579 respiratory system disease A respiratory system disease that is characterized by deprivation of oxygen to a newborn infant that lasts long enough during the birth process to cause physical harm, usually to the brain. http://purl.obolibrary.org/obo/DOID_11100 Q fever http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that is a zoonotic infectious disease affecting multiple organs, has_material_basis_in Coxiella burnetii, which is transmitted_by inhalation of air contaminated by barnyard dust containing dried placental material, birth fluids, or excreta of infected herd animals, transmitted_by ingestion of contaminated milk, transmitted_by tick bites and transmitted_by contact with infected person. The infection has_symptom fever, has_symptom headache, has_symptom cough, has_symptom pleuritic chest pain, has_symptom myalgia and has_symptom arthralgia. http://purl.obolibrary.org/obo/DOID_11101 trench fever http://purl.obolibrary.org/obo/DOID_11102 bartonellosis A primary bacterial infectious disease that results in systemic infection, has_material_basis_in Bartonella quintana, which is transmitted by body lice (Pediculus humanus corporis). The infection has symptom relapsing fever, has symptom headache, has symptom shin pain, and has symptom soreness of the muscles of the legs and back. http://purl.obolibrary.org/obo/DOID_11102 bartonellosis http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that is caused by the bacteria of the genus Bartonella. http://purl.obolibrary.org/obo/DOID_11104 spotted fever http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that results in infection, located in endothelial cell of artery or located in endothelial cell of vein, has_material_basis_in Rickettsia, which is transmitted by ticks and mites. The infection has symptom fever, has symptom headache, has symptom fatigue, has symptom muscle aches, and has symptom maculopapular or petechial rash. A distinctive eschar (blackened or crusted skin) may develop at the site of a tick bite. http://purl.obolibrary.org/obo/DOID_11105 fundus albipunctatus http://purl.obolibrary.org/obo/DOID_8501 fundus dystrophy A fundus dystrophy that is characterized by discrete uniform white dots over the entire fundus with greatest density in the midperiphery and no macular involvement. http://purl.obolibrary.org/obo/DOID_11119 Gilles de la Tourette syndrome http://purl.obolibrary.org/obo/DOID_2769 tic disorder A tic disorder that is characterized by multiple physical (motor) tics and at least one vocal (phonic) tic present for more than a year. http://purl.obolibrary.org/obo/DOID_11123 Henoch-Schoenlein purpura http://purl.obolibrary.org/obo/DOID_9809 hypersensitivity vasculitis A hypersensitivity vasculitis that is characterized by purpura (purplish plaques), arthralgia, gastrointestinal upset, and/or glomerulonephritis, and may be related to increased immune response following an infection. http://purl.obolibrary.org/obo/DOID_1115 sarcoma http://purl.obolibrary.org/obo/DOID_0050687 cell type cancer A cell type cancer that has_material_basis_in abnormally proliferating cells derives from embryonic mesoderm. http://purl.obolibrary.org/obo/DOID_11153 miliaria rubra http://purl.obolibrary.org/obo/DOID_1382 miliaria A miliaria that is characterized by erythematous papules resulting in leakage of sweat into the deeper, subcorneal layers of the epidermis provoking a local inflammatory reaction. http://purl.obolibrary.org/obo/DOID_11155 hypohidrosis http://purl.obolibrary.org/obo/DOID_1383 sweat gland disease A sweat gland disease that is characterized by reduced ability to sweat, has_symptom hyperthermia and dry skin of affected areas, and has_material_basis_in trauma to the sweat glands. http://purl.obolibrary.org/obo/DOID_11156 anhidrosis http://purl.obolibrary.org/obo/DOID_11155 hypohidrosis A hypohidrosis that is characterized by the inability to sweat and has_symptom hyperthermia and dry skin. http://purl.obolibrary.org/obo/DOID_1116 pertussis http://purl.obolibrary.org/obo/DOID_0050339 commensal bacterial infectious disease A commensal bacterial infectious disease that results_in inflammation located_in respiratory tract, has_material_basis_in Bordetella pertussis, or has_material_basis_in Bordetella parapertussis, which produce toxins that paralyze the cilia of the respiratory epithelial cells. The infection is characterized by a prolonged, high-pitched, deeply indrawn breath (whoop). http://purl.obolibrary.org/obo/DOID_11162 respiratory failure http://purl.obolibrary.org/obo/DOID_850 lung disease A lung disease characterized by inadequate gas exchange by the respiratory system. http://purl.obolibrary.org/obo/DOID_11165 common wart http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in infection located_in skin, has_material_basis_in human papillomavirus (types 2 and 4). This infection has_symptom raised wart with roughened surface, most common on hands, but can grow anywhere on the body. http://purl.obolibrary.org/obo/DOID_11168 anogenital venereal wart http://purl.obolibrary.org/obo/DOID_3128 anus disease A viral infectious disease that results_in infection located_in skin of vagina, cervix, uterus, anus, penis, scrotum, mouth, and throat, has_material_basis_in human papillomaviruses (types 6 and 11), which are transmitted_by direct contact with the skin during oral, genital, or anal sex with an infected partner. The infection has_symptom anogenital warts. http://purl.obolibrary.org/obo/DOID_11180 non-suppurative otitis media http://purl.obolibrary.org/obo/DOID_10754 otitis media A otitis media which involves transudation of fluid in the middle ear without pus formation. http://purl.obolibrary.org/obo/DOID_11193 syndactyly http://purl.obolibrary.org/obo/DOID_11971 synostosis A synostosis that results_in the fusion of two or more digits. http://purl.obolibrary.org/obo/DOID_11198 DiGeorge syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that has_material_basis_in a large deletion of the chromosome 22q11.2 region which includes the DGS gene needed for development of the thymus and related glands with subsequent lack of T-cell production. http://purl.obolibrary.org/obo/DOID_11199 hypoparathyroidism http://purl.obolibrary.org/obo/DOID_11201 parathyroid gland disease A parathyroid gland disease characterized by decreased function of parathyroid glands with underproduction of parathyroid hormone (PTH), leading to abnormally low ionized calcium levels in the blood. http://purl.obolibrary.org/obo/DOID_11200 T cell deficiency http://purl.obolibrary.org/obo/DOID_612 primary immunodeficiency disease A primary immunodeficiency disease that is characterized by decreased numbers of circulating or functioning T cells. http://purl.obolibrary.org/obo/DOID_11201 parathyroid gland disease http://purl.obolibrary.org/obo/DOID_28 endocrine system disease An endocrine system disease that is located_in the parathyroid gland. http://purl.obolibrary.org/obo/DOID_11204 allergic conjunctivitis http://purl.obolibrary.org/obo/DOID_2475 chronic conjunctivitis A chronic conjunctivitis that is an inflammation of the conjunctiva involing red, itchy, and watery eyes a resulting from an exposure to an allergen or an irritant. http://purl.obolibrary.org/obo/DOID_11206 opioid abuse http://purl.obolibrary.org/obo/DOID_302 substance abuse A substance abuse that involves the recurring use of opioid drugs despite negative consequences. http://purl.obolibrary.org/obo/DOID_11227 acute hemorrhagic conjunctivitis http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results in inflammation located in conjunctiva, has_material_basis_in Human coxsackievirus A24 or has_material_basis_in Human enterovirus 70, which are transmitted by contaminated fomites or transmitted by contact with contaminated hands. The infection has symptom vascular dilation, has symptom eyelid edema, has symptom photophobia, has symptom redness of the eyes, has symptom watering of the eye, has symptom conjunctival congestion, and has symptom superficial punctate epithelial keratitis. http://purl.obolibrary.org/obo/DOID_11234 orbital cellulitis http://purl.obolibrary.org/obo/DOID_11230 acute orbital inflammation An acute orbital inflammation that is characterized by painful orbital mass and has_symptom eyelid edema, has_symptom erythema, has_symptom chemiosis, has_symptom proptosis, has_symptom blurred vision, has_symptom headache, has_symptom fever and has_symptom double vision. http://purl.obolibrary.org/obo/DOID_11239 appendix cancer http://purl.obolibrary.org/obo/DOID_60000 appendix disease A intestinal cancer that is located_in the appendix. http://purl.obolibrary.org/obo/DOID_11249 vitamin K deficiency bleeding http://purl.obolibrary.org/obo/DOID_5113 nutritional deficiency disease A nutritional deficiency disease that is characterized by easy bleeding due to an inability to form blood clots caused by vitamin K deficiency, occurs most commonly in newborns, and has_material_basis_in deficiency of vitamin K secondary to liver prematurity, lack of vitamin K in a breastmillk diet, largely sterile gut, malabsorption, diarrhea, chronic illness, menorrhagia, chronic kidney disease, and some medications. http://purl.obolibrary.org/obo/DOID_11256 typhus http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that refers to a group of diseases, located in endothelial cells of the small venous, arterial, and capillary vessels, has_material_basis_in Rickettsia bacteria, which are transmitted by lice, transmitted by fleas, and transmitted by mites. http://purl.obolibrary.org/obo/DOID_11258 cat-scratch disease http://purl.obolibrary.org/obo/DOID_9942 lymph node disease A bartonellosis that results_in infection located_in lymph node, has_material_basis_in Bartonella henselae or has_material_basis_in Bartonella clarridgeiae, which are transmitted_by scratch or bite of a kitten, or transmitted_by contact of animal's saliva with an eye or through broken skin. The infection has_symptom regional lymphadenopathy, has_symptom headache, has_symptom chills, has_symptom backache, and has_symptom abdominal pain. http://purl.obolibrary.org/obo/DOID_11260 rabies http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results in inflammation located in brain or located in spinal cord, has_material_basis_in Rabies virus, which is transmitted by bite of an infected animal, or transmitted by contact of mucous membranes with saliva of an infected animal. The infection has symptom fever, has symptom headache, has symptom prickling or itching sensation at the site of bite, has symptom anxiety, has symptom confusion, has symptom agitation, has symptom delirium, has symptom difficulty swallowing, has symptom hydrophobia, and has symptom paralysis. http://purl.obolibrary.org/obo/DOID_11262 ornithosis http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that results_in systemic infection, has_material_basis_in Chlamydia psittaci, which is transmitted_by inhaling aerosolized dried droppings or transmitted_by contact with infected birds. The infection has_symptom fever, has_symptom headache, has_symptom rash, has_symptom chills, and has_symptom pneumonia. http://purl.obolibrary.org/obo/DOID_11265 trachoma http://purl.obolibrary.org/obo/DOID_5614 eye disease A commensal bacterial infectious disease that results_in infection located_in eye, has_material_basis_in Chlamydia trachomatis (A, B, Ba and C serovars), which is transmitted_by contact with eye discharge from the infected person and transmitted_by congenital method. The infection causes eyelid to turn inward which makes eyelashes to scratch the cornea. http://purl.obolibrary.org/obo/DOID_11266 Hantavirus hemorrhagic fever with renal syndrome http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that is a hemorrhagic fever, located in kidney, has_material_basis_in Hantaan virus, has_material_basis_in Dobrava-Belgrade orthohantavirus has_material_basis_in Seoul virus, or has_material_basis_in Puumala virus, which are carried and transmitted by rodents. The infection has symptom headache, has symptom fever, has symptom muscle pains, has symptom facial flush, has symptom petechiae, has symptom hemorrhagic features, has symptom proteinuria, and has symptom renal failure. http://purl.obolibrary.org/obo/DOID_11294 arteriovenous malformation http://purl.obolibrary.org/obo/DOID_255 hemangioma A hemangioma that is characterized by a configuration of blood vessels that shunts arterial blood directly into veins by bypassing the capillary system. http://purl.obolibrary.org/obo/DOID_11302 cercarial dermatitis http://purl.obolibrary.org/obo/DOID_37 skin disease A schistosomiasis that is a short-term, cutaneous inflammatory response associated with penetration of the skin by cercariae of bird schistosome, Austrobilharzia variglandis. The disease has symptom skin reddening, has symptom skin itching, in the water or immediately after emerging and has symptom itchy, raised papules, occur within hours of infection. http://purl.obolibrary.org/obo/DOID_11320 Kyasanur forest disease http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Kyasanur forest disease virus, which is transmitted by Haemaphysalis spinigera tick bite. The infection has symptom fever, has symptom headache, has symptom stiffness of the neck, has symptom severe muscle pain, has symptom cough, has symptom dehydration, and has symptom bleeding problems. http://purl.obolibrary.org/obo/DOID_11335 sarcoidosis http://purl.obolibrary.org/obo/DOID_2916 hypersensitivity reaction type IV disease A hypersensitivity reaction type IV disease characterized by the growth of collections of inflammatory cells (granulomas) in multiple organs. http://purl.obolibrary.org/obo/DOID_11336 rhinoscleroma http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that involves the inflammation of mucosa lining the nasal cavity, pharynx, larynx, trachea and bronchi that is characterized by the formation of granulomas, dense induration of the tissues and nodular deformity caused by Klebsiella rhinoscleromatis. http://purl.obolibrary.org/obo/DOID_11338 tetanus http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that results in prolonged contraction of skeletal muscle fibers, has_material_basis_in Clostridium tetani, which produces tetanospasmin, a neurotoxin, which is carried to the brain and spinal cord, where it binds irreversibly to receptors inhibiting neurotransmission. Damaged upper motor neurons cannot control reflex responses to afferent sensory stimuli. http://purl.obolibrary.org/obo/DOID_11339 pneumocystosis http://purl.obolibrary.org/obo/DOID_850 lung disease An opportunistic mycosis that is located in lungs, but can also occur in eyes, ears, skin, thyroid, pituitary, palate, parathyroid, esophagus, pleura, heart, liver, spleen, small intestine, adrenals, kidneys, bone marrow, and lymph nodes, has_material_basis_in Pneumocystis jirovecii that effects interstitial and alveolar tissues and has symptom nonproductive cough, has symptom shortness of breath, and has symptom fever. http://purl.obolibrary.org/obo/DOID_11343 scleral disease http://purl.obolibrary.org/obo/DOID_5614 eye disease An eye disease that affects the sclera, which is the white fibrous outer layer of the eyeball. http://purl.obolibrary.org/obo/DOID_11360 Phlebotomus fever http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results in infection, has_material_basis_in Sandfly fever Naples virus, or has_material_basis_in Sandfly fever sicilian virus, which are transmitted by Phlebotomus papatasi sandfly. The infection has symptom fever, has symptom severe frontal headaches, has symptom muscle ache, has symptom joint aches, has symptom flushing of the face, and has symptom tachycardia. http://purl.obolibrary.org/obo/DOID_11372 megacolon http://purl.obolibrary.org/obo/DOID_5353 colonic disease A colonic disease that is characterized by an abnormal dilation of the colon. http://purl.obolibrary.org/obo/DOID_11379 gnathomiasis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that involves parasitic infection due to migrating immature worms of Gnathostoma spinigerum or Gnathostoma hispidum, which occurs by eating undercooked fish or poultry containing third-stage larvae, or by drinking water containing infective second-stage larvae in Cyclops. Migration in the subcutaneous tissues causes intermittent, migratory, painful, pruritic swellings (cutaneous larva migrans). Migration to other tissues (visceral larva migrans), result in cough, hematuria, and ocular involvement, with the most serious manifestations eosinophilic meningitis with myeloencephalitis. http://purl.obolibrary.org/obo/DOID_11385 expressive language disorder http://purl.obolibrary.org/obo/DOID_93 language disorder A language disorder that involves difficulties with verbal and written expression characterized by an ability to use expressive spoken language that is markedly below the appropriate level for the mental age, but with a language comprehension that is within normal limits. http://purl.obolibrary.org/obo/DOID_11387 epidural abscess http://purl.obolibrary.org/obo/DOID_331 central nervous system disease A central nervous system disease that is characterized by a collection of pus (infected material) between the outer covering of the brain and spinal cord and the bones of the skull or spine and is caused by infection in the area between the bones of the skull or spine, and the membranes covering the brain and spinal cord (meninges). http://purl.obolibrary.org/obo/DOID_11394 adult respiratory distress syndrome http://purl.obolibrary.org/obo/DOID_11162 respiratory failure A respiratory failure that results from diffuse injury to the endothelium of the lung (as in sepsis, chest trauma, massive blood transfusion, aspiration of the gastric contents, or pneumonia) and is characterized by pulmonary edema with an abnormally high amount of protein in the edematous fluid and by difficult rapid breathing and hypoxemia. http://purl.obolibrary.org/obo/DOID_114 heart disease http://purl.obolibrary.org/obo/DOID_1287 cardiovascular system disease A cardiovascular system disease that involves the heart. http://purl.obolibrary.org/obo/DOID_11405 diphtheria http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that is characterized by sore throat, low fever, and an adherent membrane (a pseudomembrane) on the tonsils, pharynx, and/or nasal cavity. A milder form of diphtheria can be restricted to the skin. It is caused by Corynebacterium diphtheriae, an aerobic Gram-positive bacterium. Diphtheria toxin spreads through the bloodstream and can lead to potentially life-threatening complications that affect other organs of the body, such as the heart and kidneys. http://purl.obolibrary.org/obo/DOID_11427 endosalpingiosis http://purl.obolibrary.org/obo/DOID_289 endometriosis A female reproductive system disease characterized by the growth of fallopian tube-like epithelium outside the fallopian tube. http://purl.obolibrary.org/obo/DOID_11457 brain compression http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is characterized by pressure on the intracranial tissues by an effusion of blood or cerebrospinal fluid, an abscess, a neoplasm, a depressed fracture of the skull, or edema of the brain. http://purl.obolibrary.org/obo/DOID_11476 osteoporosis http://purl.obolibrary.org/obo/DOID_0080011 bone resorption disease A bone resorption disease characterized by decreased density of normally mineralized bone which results_in the thinning of bone tissue and decreased mechanical strength. http://purl.obolibrary.org/obo/DOID_1148 polydactyly http://purl.obolibrary.org/obo/DOID_0080015 physical disorder A physical disorder that is characterized by the presence of more than five fingers per hand or five toes per foot. http://purl.obolibrary.org/obo/DOID_11482 hemopericardium http://purl.obolibrary.org/obo/DOID_118 pericardial effusion A pericardial effusion that results from blood in the pericardial sac. http://purl.obolibrary.org/obo/DOID_115 cardiac tamponade http://purl.obolibrary.org/obo/DOID_118 pericardial effusion A pericardial effusion in which fluid accumulates in the pericardium (the sac in which the heart is enclosed) and the pericardial spaces fills up faster than the pericardial sac can stretch. http://purl.obolibrary.org/obo/DOID_11506 suppurative otitis media http://purl.obolibrary.org/obo/DOID_10754 otitis media A otitis media which involves inflammation of the middle ear with infected effusion containing pus. http://purl.obolibrary.org/obo/DOID_11516 hypertensive heart disease http://purl.obolibrary.org/obo/DOID_114 heart disease A heart disease that is caused by high blood pressure. http://purl.obolibrary.org/obo/DOID_11555 Fuchs' endothelial dystrophy http://purl.obolibrary.org/obo/DOID_0060443 corneal endothelial dystrophy A corneal dystrophy characterized by accumulation of focal outgrowths (guttae) and thickening of Descemet's membrane, leading to corneal edema and loss of vision. http://purl.obolibrary.org/obo/DOID_1156 chondrocalcinosis http://purl.obolibrary.org/obo/DOID_848 arthritis An arthritis that has_material_basis_in the accumulation of salt crystals located_in joint. http://purl.obolibrary.org/obo/DOID_11569 neurocirculatory asthenia http://purl.obolibrary.org/obo/DOID_4737 somatoform disorder A somatoform disorder that involves heart disease symptoms without any identifiable physiological abnormatlities. http://purl.obolibrary.org/obo/DOID_11573 listeriosis http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that results_in infection, has_material_basis_in Listeria monocytogenes, which is transmitted_by ingestion of contaminated food or raw milk or transmitted_by congenital method. Ingestion of Listeria by pregnant women has_symptom nausea, has_symptom vomiting, has_symptom diarrhea, has_symptom fever, has_symptom malaise, has_symptom back pain, and has_symptom headache. Maternal infection with Listeria can result in chorioamnionitis, premature labor, spontaneous abortion, or stillbirth. http://purl.obolibrary.org/obo/DOID_11577 Cauda equina syndrome http://purl.obolibrary.org/obo/DOID_574 peripheral nervous system disease A peripheral nervous system disease that involves an acute loss of function of the lumbar plexus, neurologic elements (nerve roots) of the spinal canal below the termination (conus) of the spinal cord. http://purl.obolibrary.org/obo/DOID_11608 fungal meningitis http://purl.obolibrary.org/obo/DOID_9471 meningitis A meningitis that has_material_basis_in a fungal infection. http://purl.obolibrary.org/obo/DOID_11612 polycystic ovary syndrome http://purl.obolibrary.org/obo/DOID_1414 ovarian dysfunction An ovarian dysfunction that is characterized by hyperandrogenism, polycystic ovaries, hirsutism, oligomenorrhea or amenorrhea, anovulation and excessive body weight. http://purl.obolibrary.org/obo/DOID_11656 cicatricial pemphigoid http://purl.obolibrary.org/obo/DOID_8502 bullous skin disease A bullous skin disease characterized by skin lesions and scaring and located_in mucous membranes and located_in skin. http://purl.obolibrary.org/obo/DOID_1166 palindromic rheumatism http://purl.obolibrary.org/obo/DOID_848 arthritis An arthritis that involves sudden and rapidly developing attacks of arthritis with a remission period that results_in no joint damage or symptoms. http://purl.obolibrary.org/obo/DOID_11661 blue color blindness http://purl.obolibrary.org/obo/DOID_13399 color blindness A color blindness that is characterised by a selective deficiency of blue vision, has_material_basis_in autosomal dominant inheritance of a mutation in the OPN1SW gene and is associated with a deficiency or absence of blue-sensitive cone photoreceptor function. http://purl.obolibrary.org/obo/DOID_11678 onchocerciasis http://purl.obolibrary.org/obo/DOID_1080 filariasis A filariasis that involves parasitic infection caused by the nematode Onchocerca volvulus, which is transmitted to humans through the bite of a blackfly of the genus Simulium. The worms spread throughout the body and, when they die, cause intense itching and a strong immune system response that can destroy nearby tissue. The symptoms include pruritus, dermatitis, blindness, onchocercomata (subcutaneous nodules), and lymphadenopathy. http://purl.obolibrary.org/obo/DOID_11695 portal vein thrombosis http://purl.obolibrary.org/obo/DOID_0060903 thrombosis A hepatic vascular disease that is characterized by a blood clot that forms within the hepatic portal vein. http://purl.obolibrary.org/obo/DOID_117 heart cancer http://purl.obolibrary.org/obo/DOID_176 cardiovascular cancer A cardiovascular cancer located_in the heart. http://purl.obolibrary.org/obo/DOID_11702 dysgammaglobulinemia http://purl.obolibrary.org/obo/DOID_6025 selective immunoglobulin deficiency disease A selective immunoglobulin deficiency disease that is caused by a reduction in some types of gamma globulins. http://purl.obolibrary.org/obo/DOID_11713 diabetic angiopathy http://purl.obolibrary.org/obo/DOID_341 peripheral vascular disease A peripheral vascular disease that is characterized by narrowing of the arteries as a complication arising from chronic diabetes. http://purl.obolibrary.org/obo/DOID_11714 gestational diabetes http://purl.obolibrary.org/obo/DOID_9351 diabetes mellitus A diabetes mellitus that manifests during pregnancy. http://purl.obolibrary.org/obo/DOID_11716 prediabetes syndrome http://purl.obolibrary.org/obo/DOID_4194 glucose metabolism disease A glucose metabolism disease that is characterized by blood glucose levels are high, but not high enough to be classified as type 2 diabetes. http://purl.obolibrary.org/obo/DOID_11717 neonatal diabetes http://purl.obolibrary.org/obo/DOID_9351 diabetes mellitus A diabetes mellitus that is characterized by hyperglycemia occuring within the first 6 months of life. http://purl.obolibrary.org/obo/DOID_11720 distal myopathy http://purl.obolibrary.org/obo/DOID_9884 muscular dystrophy A muscular dystrophy that is characterized by predominant weakness and atrophy beginning in the feet and/or hands. http://purl.obolibrary.org/obo/DOID_11722 myotonic dystrophy type 1 http://purl.obolibrary.org/obo/DOID_450 myotonic disease A myotonic disease that is characterized by progressive muscle wasting and weakness affecting the distal skeletal and smooth muscles of lower legs, hands, neck, and face along with myotonia and cataracts and has_material_basis_in the autosomal dominant inheritance of the DMPK gene containing an expansion of a CTG trinucleotide repeat in the non-coding region. http://purl.obolibrary.org/obo/DOID_11723 Duchenne muscular dystrophy http://purl.obolibrary.org/obo/DOID_9884 muscular dystrophy A muscular dystrophy that has_material_basis_in X-linked mutations in the DMD gene found on the X chromosome. It is characterized by rapidly progressing muscle weakness and muscle atrophy initially involving the lower extremities and eventually affecting the whole body. It affects males whereas females can be carriers. The symptoms start before the age of six and may appear at infancy. http://purl.obolibrary.org/obo/DOID_11724 limb-girdle muscular dystrophy http://purl.obolibrary.org/obo/DOID_9884 muscular dystrophy A muscular dystrophy that is characterized by weakening of the muscles of the hip and shoulders which comprise the limb girdle muscles. http://purl.obolibrary.org/obo/DOID_11725 Cornelia de Lange syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by slow growth before and after birth, intellectual disability that is usually severe to profound, skeletal abnormalities involving the arms and hands, and distinctive facial features. http://purl.obolibrary.org/obo/DOID_11726 Emery-Dreifuss muscular dystrophy http://purl.obolibrary.org/obo/DOID_9884 muscular dystrophy A muscular dystrophy that chiefly affects muscles used for movement (skeletal) and heart (cardiac) muscle. http://purl.obolibrary.org/obo/DOID_11729 Lyme disease http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia burgdorferi, which is transmitted_by blacklegged tick (Ixodes scapularis) or transmitted_by western blacklegged tick (Ixodes pacificus). The infection has_symptom fever, has_symptom headache, has_symptom fatigue, and has_symptom skin rash called erythema migrans. If left untreated, infection can spread to joints, the heart, and the nervous system. http://purl.obolibrary.org/obo/DOID_1176 bronchial disease http://purl.obolibrary.org/obo/DOID_0050161 lower respiratory tract disease A lower respiratory tract disease that affects the airways leading into the lungs, which is caused due to inflammation of the bronchi and bronchioles, infection, or blockage. http://purl.obolibrary.org/obo/DOID_11782 astigmatism http://purl.obolibrary.org/obo/DOID_9835 refractive error A refractive error characterized by the optics of the eye to focus a point object into a sharp focused image on the retina, has_symptom blurred vision. http://purl.obolibrary.org/obo/DOID_118 pericardial effusion http://purl.obolibrary.org/obo/DOID_0050829 pericardium disease A pericardium disease that is characterized by an abnormal accumulation of fluid in the pericardial cavity. http://purl.obolibrary.org/obo/DOID_11801 protein-energy malnutrition http://purl.obolibrary.org/obo/DOID_5113 nutritional deficiency disease A nutritional deficiency disease that is characterized by inadequate dietary protein and calories, which can have profound systemic effects including decreased metabolism, altered tissue distribution, compromised immunity, and impaired growth, and has_material_basis_in dietary deprivation. http://purl.obolibrary.org/obo/DOID_11819 ureter cancer http://purl.obolibrary.org/obo/DOID_3996 urinary system cancer A urinary system cancer that is located_in the ureter. http://purl.obolibrary.org/obo/DOID_11824 multicentric reticulohistiocytosis http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by papulonodular skin lesions containing a proliferation of true macrophages associated with arthritis. http://purl.obolibrary.org/obo/DOID_11830 myopia http://purl.obolibrary.org/obo/DOID_9835 refractive error A refractive error characterized by the inability to see farther objects clearly. http://purl.obolibrary.org/obo/DOID_11836 clubfoot http://purl.obolibrary.org/obo/DOID_0080006 bone development disease A bone development disease where one or both are inclined inwards, axially rotated outwards, and pointing downwards with concomitant soft tissue abnormalities. http://purl.obolibrary.org/obo/DOID_1184 nephrotic syndrome http://purl.obolibrary.org/obo/DOID_2527 nephrosis A nephrosis characterized by marked increase in glomerular protein permeability resulting in marked elevation of urine protein levels, hypoalbuminemia, hyperlipidemia, and hypercoagulability. http://purl.obolibrary.org/obo/DOID_1188 mononeuropathy http://purl.obolibrary.org/obo/DOID_870 neuropathy A neuropathy that is characterized by damage to a single nerve, which results in loss of movement, sensation, or other function of that nerve. http://purl.obolibrary.org/obo/DOID_119 vaginal cancer http://purl.obolibrary.org/obo/DOID_121 vaginal disease A female reproductive system cancer that is located_in the vagina. http://purl.obolibrary.org/obo/DOID_11917 tinea cruris http://purl.obolibrary.org/obo/DOID_8913 dermatophytosis A dermatophytosis that results_in fungal skin infection located_in groin, located_in perineum, or located_in perianal region, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching in groin, thigh skin folds, or anus and results_in_formation_of rash which appears as raised red plaques (platelike areas) and scaly patches with sharply defined borders that may blister and ooze. http://purl.obolibrary.org/obo/DOID_1192 peripheral nervous system neoplasm http://purl.obolibrary.org/obo/DOID_574 peripheral nervous system disease A nervous system cancer that is located in the peripheral nervous system. http://purl.obolibrary.org/obo/DOID_11920 tracheal cancer http://purl.obolibrary.org/obo/DOID_3225 tracheal disease A respiratory system cancer that is located_in the trachea. http://purl.obolibrary.org/obo/DOID_11934 head and neck cancer http://purl.obolibrary.org/obo/DOID_162 cancer An organ system cancer that arises in the head or neck region. This region includes the nasal cavity, sinuses, lips, mouth, salivary glands, throat, or larynx. http://purl.obolibrary.org/obo/DOID_11971 synostosis http://purl.obolibrary.org/obo/DOID_1934 dysostosis A dysostosis that results_in abnormal fusing of adjacent bones. http://purl.obolibrary.org/obo/DOID_11976 botulism http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) located in neuromuscular junction resulting in descending muscle paralysis, has_material_basis_in Clostridium botulinum A, has_material_basis_in Clostridium botulinum B, has_material_basis_in Clostridium botulinum E and has_material_basis_in Clostridium botulinum F. http://purl.obolibrary.org/obo/DOID_11983 Prader-Willi syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A chromosomal disease that is characterized by weak muscle tone, feeding difficulties, poor growth, and delayed development. Beginning in childhood, affected individuals develop an insatiable appetite, which leads to chronic overeating and obesity. http://purl.obolibrary.org/obo/DOID_11984 hypertrophic cardiomyopathy http://purl.obolibrary.org/obo/DOID_0060036 intrinsic cardiomyopathy An intrinsic cardiomyopathy that is characterized by abnormal thickening (hypertrophy) of the heart without any obvious cause. http://purl.obolibrary.org/obo/DOID_11991 osteopoikilosis http://purl.obolibrary.org/obo/DOID_4254 osteosclerosis An osteosclerosis that results_in numerous bone islands located_in skeleton. http://purl.obolibrary.org/obo/DOID_120 female reproductive organ cancer http://purl.obolibrary.org/obo/DOID_229 female reproductive system disease A reproductive organ cancer that is manifested in the female genitals. This includes organs such as the ovaries, fallopian tubes, uterus, cervix, vagina and vulva. http://purl.obolibrary.org/obo/DOID_12028 Conn's syndrome http://purl.obolibrary.org/obo/DOID_656 adrenal adenoma An adrenal adenoma characterized by the over production of aldosterone. http://purl.obolibrary.org/obo/DOID_12030 panuveitis http://purl.obolibrary.org/obo/DOID_13141 uveitis An uveitis that is characterized by inflammation of all layers of the uvea (middle layer) of the eye, which includes the iris, ciliary body, and choroid. http://purl.obolibrary.org/obo/DOID_1205 allergic disease http://purl.obolibrary.org/obo/DOID_2914 immune system disease An immune system disease that is an exaggerated immune response to allergens, such as insect venom, dust mites, pollen, pet dander, drugs or some foods. http://purl.obolibrary.org/obo/DOID_12053 cryptococcosis http://purl.obolibrary.org/obo/DOID_2473 opportunistic mycosis An opportunistic mycosis that results_in fungal infection and has_material_basis_in Cryptococcus neoformans or Cryptococcus gattii. http://purl.obolibrary.org/obo/DOID_1206 Rett syndrome http://purl.obolibrary.org/obo/DOID_0060040 pervasive developmental disorder A pervasive developmental disease that is characterized by normal early growth and development followed by a slowing of development, loss of purposeful use of the hands, distinctive hand movements, slowed brain and head growth, problems with walking, seizures, and intellectual disability. http://purl.obolibrary.org/obo/DOID_121 vaginal disease http://purl.obolibrary.org/obo/DOID_229 female reproductive system disease A female reproductive system disease that is located_in the vagina. http://purl.obolibrary.org/obo/DOID_1210 optic neuritis http://purl.obolibrary.org/obo/DOID_1891 optic nerve disease An optic nerve disease that results_in inflammation located_in optic nerve which may cause a complete or partial loss of vision. http://purl.obolibrary.org/obo/DOID_12117 pulmonary alveolar microlithiasis http://purl.obolibrary.org/obo/DOID_850 lung disease A lung disease that is characterized the accumulation of tiny fragments of calcium phosphate gradually accumulate in the alveoli of the lungs. http://purl.obolibrary.org/obo/DOID_12119 hemosiderosis http://purl.obolibrary.org/obo/DOID_2351 iron metabolism disease An iron metabolism disease that has_material_basis_in an accumulation of hemosiderin, an iron-storage complex, resulting in iron overload. http://purl.obolibrary.org/obo/DOID_12120 pulmonary alveolar proteinosis http://purl.obolibrary.org/obo/DOID_850 lung disease A lung disease that is characterized by abnormal accumulation of surfactant occurs within the alveoli, interfering with gas exchange. http://purl.obolibrary.org/obo/DOID_12132 granulomatosis with polyangiitis http://purl.obolibrary.org/obo/DOID_850 lung disease An autoimmune disease that is characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis, vasculitis, and the presence of antineutrophil cytoplasmatic autoantibodies (ANCAs) in patient sera, and is located_in lung, located_in kidney, located_in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels. http://purl.obolibrary.org/obo/DOID_12134 factor VIII deficiency http://purl.obolibrary.org/obo/DOID_1247 blood coagulation disease A blood coagulation disease that has_material_basis_in Factor VIII deficiency, which results in the formation of fibrin deficient clots which makes coagulation much more prolonged. http://purl.obolibrary.org/obo/DOID_12139 dysthymic disorder http://purl.obolibrary.org/obo/DOID_3324 mood disorder A mood disorder that involves the presence of a low mood almost daily over a span of at least two years. http://purl.obolibrary.org/obo/DOID_12140 Chagas disease http://purl.obolibrary.org/obo/DOID_10113 trypanosomiasis A trypanosomiasis that is a tropical parasitic disease caused by the flagellate protozoan Trypanosoma cruzi, which is transmitted to humans and other mammals by an insect vector, the blood-sucking assassin bugs of the subfamily Triatominae (family Reduviidae), most commonly species belonging to the Triatoma, Rhodnius, and Panstrongylus genera. The symptoms include fever, fatigue, body aches, headache, rash, loss of appetite, diarrhea, vomiting, swelling of the eyelids and myocarditis. http://purl.obolibrary.org/obo/DOID_12155 lymphocytic choriomeningitis http://purl.obolibrary.org/obo/DOID_936 brain disease A viral infectious disease that results in infection located in brain, or located in meninges, or located in brain and meninges, has_material_basis_in Lymphocytic choriomeningitis virus, which is transmitted by common house mouse, Mus musculus. The infection has symptom fever, has symptom lack of appetite, has symptom headache, has symptom muscle aches, has symptom malaise, has symptom nausea, and has symptom vomiting. http://purl.obolibrary.org/obo/DOID_12176 goiter http://purl.obolibrary.org/obo/DOID_50 thyroid gland disease A thyroid gland disease that involves an abnormal enlargement of the thyroid gland. http://purl.obolibrary.org/obo/DOID_12177 common variable immunodeficiency http://purl.obolibrary.org/obo/DOID_417 autoimmune disease An agammaglobulinemia that is results in insufficient production of antibodies needed to respond to exposure of pathogens and is characterized by low Ig levels with phenotypically normal B cells that can proliferate but do not develop into Ig-producing cells. http://purl.obolibrary.org/obo/DOID_12185 otosclerosis http://purl.obolibrary.org/obo/DOID_2952 inner ear disease An otitis interna characterized by an abnormal bone growth in the middle ear. http://purl.obolibrary.org/obo/DOID_12205 dengue disease http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results in infection, has_material_basis_in Dengue virus [NCBITaxon:12637] with four serotypes (Dengue virus 1, 2, 3 and 4), which are transmitted by Aedes mosquito bite. The infection has symptom fever, has symptom severe headache, has symptom severe pain behind the eyes, has symptom joint pain, has symptom muscle and bone pain, has symptom rash, and has symptom mild bleeding. http://purl.obolibrary.org/obo/DOID_12215 oligohydramnios http://purl.obolibrary.org/obo/DOID_780 placenta disease A placenta disease that is characterized by a deficiency of amniotic fluid sometimes resulting in an embryonic defect through adherence between embryo and amnion. http://purl.obolibrary.org/obo/DOID_12217 Lewy body dementia http://purl.obolibrary.org/obo/DOID_1307 dementia A dementia that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities. http://purl.obolibrary.org/obo/DOID_1222 cartilage disease http://purl.obolibrary.org/obo/DOID_65 connective tissue disease A connective tissue disease that is located_in cartilage. http://purl.obolibrary.org/obo/DOID_12236 primary biliary cholangitis http://purl.obolibrary.org/obo/DOID_5082 liver cirrhosis A liver cirrhosis characterized by chronic and slow progressive destruction of intrahepatic bile ducts. http://purl.obolibrary.org/obo/DOID_12259 hemophilia B http://purl.obolibrary.org/obo/DOID_1247 blood coagulation disease A blood coagulation disease that has_material_basis_in Factor IX deficiency, which makes coagulation much more prolonged. The disease is inherited as an X-linked recessive trait. http://purl.obolibrary.org/obo/DOID_12270 coloboma http://purl.obolibrary.org/obo/DOID_5614 eye disease An eye disease characterized by missing pieces of tissue in structures that form the eye, such as the iris, retina, choroid or optic disc. http://purl.obolibrary.org/obo/DOID_12271 aniridia http://purl.obolibrary.org/obo/DOID_240 iris disease An iris disease that is characterized by a complete or partial absence of the colored part of the eye. http://purl.obolibrary.org/obo/DOID_12287 Crimean-Congo hemorrhagic fever http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that is a hemorrhagic fever, has_material_basis_in Crimean-Congo hemorrhagic fever virus, which is transmitted_by Hyalomma ticks. The infection has_symptom headache, has_symptom high fever, has_symptom back pain, has_symptom joint pain, has_symptom stomach pain, has_symptom vomiting, has_symptom red eyes, has_symptom flushed face, has_symptom red throat, has_symptom petechiae (red spots) on the palate, has_symptom jaundice, has_symptom nosebleeds, and has_symptom blood in the feces and urine. http://purl.obolibrary.org/obo/DOID_12297 Vogt-Koyanagi-Harada disease http://purl.obolibrary.org/obo/DOID_0060039 autoimmune disease of skin and connective tissue An autoimmune disease that is caused by T helper cell mediated autoimmune attack of melanocytes resulting in inflammation of the inside of the eye, whitening of hair, skin pigment loss, and meningitis. http://purl.obolibrary.org/obo/DOID_12306 vitiligo http://purl.obolibrary.org/obo/DOID_0060039 autoimmune disease of skin and connective tissue An autoimmune disease that causes depigmentation of patches of skin resulting from loss of function or death of melanoctyes. http://purl.obolibrary.org/obo/DOID_12308 Dubin-Johnson syndrome http://purl.obolibrary.org/obo/DOID_2741 bilirubin metabolic disorder A bilirubin metabolic disorder that involves elevated levels of unconjugated bilirubin without elevation of liver alanine transaminase and aspartate transaminase enzymes as a result of the deficient ability of hepatocytes to secrete conjugated bilirubin into the bile. http://purl.obolibrary.org/obo/DOID_12318 granular corneal dystrophy http://purl.obolibrary.org/obo/DOID_0060441 epithelial-stromal TGFBI dystrophy An epithelial-stromal TGFBI dystrophy that is characterized by progressive accumulation of deposits within the layers of the cornea. http://purl.obolibrary.org/obo/DOID_1234 gender identity disorder http://purl.obolibrary.org/obo/DOID_150 disease of mental health A disease of mental health that involves a conflict between a person's actual physical gender and the gender that person identifies himself or herself as. http://purl.obolibrary.org/obo/DOID_12341 retroperitoneal sarcoma http://purl.obolibrary.org/obo/DOID_5875 retroperitoneal cancer A malignant retroperitoneal cancer and sarcoma that is located_in the retroperitoneal space. http://purl.obolibrary.org/obo/DOID_12347 osteogenesis imperfecta http://purl.obolibrary.org/obo/DOID_2256 osteochondrodysplasia An osteochondrodysplasia that has_material_basis_in a deficiency in type-I collagen which results_in brittle bones and defective connective tissue. http://purl.obolibrary.org/obo/DOID_12358 patulous eustachian tube http://purl.obolibrary.org/obo/DOID_9739 eustachian tube disease A eustachian tube disorder with a wider eustachian tube which allows a larger bolus of bacteria-laden material from the nasopharynx during an infection to enter the middle ear, causing a more fulminant infection. http://purl.obolibrary.org/obo/DOID_12361 Graves' disease http://purl.obolibrary.org/obo/DOID_0060005 autoimmune disease of endocrine system An autoimmune disease of endocrine system that involves production of excessive amount of thyroid hormones, located_in thyroid gland. http://purl.obolibrary.org/obo/DOID_12365 malaria http://purl.obolibrary.org/obo/DOID_2789 parasitic protozoa infectious disease A parasitic protozoa infectious disease characterized as a vector-borne infectious disease caused by the presence of protozoan parasites of the genus Plasmodium in the red blood cells, transmitted from an infected to an uninfected individual by the bite of anopheline mosquitoes, and characterized by periodic attacks of chills and fever that coincide with mass destruction of blood cells and the release of toxic substances by the parasite at the end of each reproductive cycle. http://purl.obolibrary.org/obo/DOID_12375 bronchopneumonia http://purl.obolibrary.org/obo/DOID_552 pneumonia A pneumonia involving inflammation of lungs that begins in the terminal bronchioles, which become clogged with thick mucus that forms consolidated patches in adjacent lobules. It is caused by bacteria and viruses. http://purl.obolibrary.org/obo/DOID_12377 spinal muscular atrophy http://purl.obolibrary.org/obo/DOID_231 motor neuron disease A motor neuron disease that is a degenerative neuromuscular disease characterized by lower motor neuron degeneration associated with progressive muscle weakness and atrophy. http://purl.obolibrary.org/obo/DOID_12384 dysentery http://purl.obolibrary.org/obo/DOID_100 intestinal infectious disease An intestinal infectious disease that involves inflammation of the intestines, especially colon, due to chemical irritants, bacteria, protozoa, or parasitic worms, which results in severe diarrhea with passage of mucus and blood. http://purl.obolibrary.org/obo/DOID_12385 shigellosis http://purl.obolibrary.org/obo/DOID_5353 colonic disease A primary bacterial infectious disease that results_in infection located_in epithelium of colon, has_material_basis_in Shigella boydii, has_material_basis_in Shigella dysenteriae, has_material_basis_in Shigella flexneri, or has_material_basis_in Shigella sonnei, which produce toxins that can attack the lining of the large intestine, causing swelling, ulcers on the intestinal wall, and bloody diarrhea. The bacteria are transmitted_by ingestion of food and water contaminated with feces. http://purl.obolibrary.org/obo/DOID_12387 nephrogenic diabetes insipidus http://purl.obolibrary.org/obo/DOID_557 kidney disease A kidney disease characterized by a complete or partial resistance of the kidneys to vasopressin (ADH). http://purl.obolibrary.org/obo/DOID_12399 pathological gambling http://purl.obolibrary.org/obo/DOID_10937 impulse control disorder An impulse control disorder that involves the uncontrollable impulse to gamble, irrespective of the interference the behaviour has on the individual's life. http://purl.obolibrary.org/obo/DOID_1240 leukemia http://purl.obolibrary.org/obo/DOID_2531 hematologic cancer A cancer that affects the blood or bone marrow characterized by an abnormal proliferation of blood cells. http://purl.obolibrary.org/obo/DOID_12400 kleptomania http://purl.obolibrary.org/obo/DOID_10937 impulse control disorder An impulse control disorder that involves the repeated impulse to steal for no great gain, when he or she has sufficient money to pay for the item and no need for what is stolen. http://purl.obolibrary.org/obo/DOID_12401 intermittent explosive disorder http://purl.obolibrary.org/obo/DOID_10937 impulse control disorder An impulse control disorder that involves the episodic inability to control violent impulses with a disproportionate degree of aggressiveness. http://purl.obolibrary.org/obo/DOID_12402 pyromania http://purl.obolibrary.org/obo/DOID_10937 impulse control disorder An impulse control disorder that involves the uncontrollable impulse to repeatedly set fires with no obvious motive. http://purl.obolibrary.org/obo/DOID_12403 tinea pedis http://purl.obolibrary.org/obo/DOID_8913 dermatophytosis A dermatophytosis that results_in fungal infection located_in skin of foot, especially between the toes, has_material_basis_in Trichophyton or has_material_basis_in Epidermophyton and has_symptom fissures, has_symptom scaling, has_symptom maceration, and eroded areas between the toes and on the plantar surface of the foot. http://purl.obolibrary.org/obo/DOID_1242 globe disease http://purl.obolibrary.org/obo/DOID_5614 eye disease An eye disease that involves the globe of the eye. http://purl.obolibrary.org/obo/DOID_12449 aplastic anemia http://purl.obolibrary.org/obo/DOID_2355 anemia An anemia that is characterized by a deficiency of red blood cells, white blood cells and platelets produced by bone marrow. http://purl.obolibrary.org/obo/DOID_1245 vulva cancer http://purl.obolibrary.org/obo/DOID_2059 vulvar disease A female reproductive organ cancer that is located_in the vulva. http://purl.obolibrary.org/obo/DOID_12450 pancytopenia http://purl.obolibrary.org/obo/DOID_2355 anemia An anemia that is characterized by a reduction in the number of red blood cells, white blood cells, and platelets. http://purl.obolibrary.org/obo/DOID_1247 blood coagulation disease http://purl.obolibrary.org/obo/DOID_74 hematopoietic system disease A hematopoietic system disease that is characterized by abnormal blood clotting or bleeding. http://purl.obolibrary.org/obo/DOID_12474 capillariasis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that involves infection of the intestine, liver and lungs caused by Capillaria species. http://purl.obolibrary.org/obo/DOID_12506 Bell's palsy http://purl.obolibrary.org/obo/DOID_13934 facial paralysis A facial paralysis resulting from dysfunction in the cranial nerve VII (facial nerve). http://purl.obolibrary.org/obo/DOID_1251 tuberculous epididymitis http://purl.obolibrary.org/obo/DOID_0080373 epididymis disease An urogenital tuberculosis that is located_in epididymis, has_symptom pain and has_symptom scrotal swelling. http://purl.obolibrary.org/obo/DOID_1252 trichuriasis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that involves parasitic infection located_in intestine in humans, has_material_basis_in Trichuris trichiura, which is transmitted_by ingestion of food contaminated with egg-carrying soil. The infection has_symptom abdominal pain, has_symptom diarrhea, has_symptom rectal prolapse and has_symptom growth retardation. http://purl.obolibrary.org/obo/DOID_12531 von Willebrand's disease http://purl.obolibrary.org/obo/DOID_1247 blood coagulation disease A blood coagulation disease that is a hereditary abnormality which slows the blood clotting process. It arises from a qualitative or quantitative deficiency of von Willebrand factor (vWF), a multimeric protein that is required for platelet adhesion. http://purl.obolibrary.org/obo/DOID_1254 trichostrongylosis http://purl.obolibrary.org/obo/DOID_1255 trichostrongyloidiasis A trichostrongyloidiasis that involves infection of the small intestine with Trichostrongylus colubriformis or Trichostrongylus axei, which results in abdominal pain, diarrhea, anorexia, headache, fatigue, anemia and eosinophilia. http://purl.obolibrary.org/obo/DOID_12549 hepatitis A http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in inflammation located_in liver, has_material_basis_in Hepatitis A virus, which is transmitted_by ingestion of contaminated food or water, or transmitted_by direct contact with an infected person. The infection has_symptom fever, has_symptom fatigue, has_symptom loss of appetite, has_symptom nausea, has_symptom vomiting, has_symptom abdominal pain, has_symptom clay-colored bowel movements, has_symptom joint pain, and has_symptom jaundice. http://purl.obolibrary.org/obo/DOID_1255 trichostrongyloidiasis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that involves parasitic infection of animals and humans by nematodes of the superfamily Trichostrongyloidea. http://purl.obolibrary.org/obo/DOID_12554 hemolytic-uremic syndrome http://purl.obolibrary.org/obo/DOID_557 kidney disease A kidney disease that is characterized by hemolytic anemia, thrombocytopenia, and renal failure caused by platelet thrombi in the microcirculation of the kidney and other organs. http://purl.obolibrary.org/obo/DOID_12559 idiopathic juvenile osteoporosis http://purl.obolibrary.org/obo/DOID_11476 osteoporosis An osteoporosis with no known cause that is characterized by pain in the back and extremities, walking difficulties, multiple fractures, and radiological evidence of osteoporosis. http://purl.obolibrary.org/obo/DOID_12568 dyscalculia http://purl.obolibrary.org/obo/DOID_8927 learning disability A learning disability involving a math disability can cause such difficulties as learning math concepts (such as quantity, place value, and time), difficulty memorizing math facts, difficulty organizing numbers, and understanding how problems are organized on the page. http://purl.obolibrary.org/obo/DOID_12571 phacogenic glaucoma http://purl.obolibrary.org/obo/DOID_1686 glaucoma A glaucoma characterized by glaucomatous optic atrophy secondary to a lens abnormality and has_symptom progressive decreased vision, especially decreased peripheral vision. Phacogenic glaucoma can be caused by cataracts, trauma to the eye, or age-related damage that obstructs aqueous outflow, leading to inappropriately increased intraocular pressure and eventual optic nerve atrophy with associated vision loss. http://purl.obolibrary.org/obo/DOID_12580 Cri-Du-Chat syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that has_material_basis_in deletion of the end of the chromosome 5 p arm and that is characterized by intellectual disability, delayed development, small head size, low birth weight, weak muscle tone widely set eyes, low-set ears, a small jaw, a rounded face and a high-pitched cry that sounds like that of a cat. http://purl.obolibrary.org/obo/DOID_12583 velocardiofacial syndrome http://purl.obolibrary.org/obo/DOID_0060388 chromosomal deletion syndrome A chromosomal deletion disease that has_material_basis_in deletion polymorphisms at chromosome location 22q11 and that is characterized by variable developmental problems and schizoid features. http://purl.obolibrary.org/obo/DOID_12594 Potter's syndrome http://purl.obolibrary.org/obo/DOID_14766 renal agenesis A renal agenesis characterized by the typical physical appearance and associated pulmonary hypoplasia of a newborn as a direct result of kidney failure, oligohydramnios and compression while in the uterus. http://purl.obolibrary.org/obo/DOID_12603 acute leukemia http://purl.obolibrary.org/obo/DOID_1037 lymphoid leukemia A lymphoid leukemia that occurs when a hematopoietic stem cell undergoes malignant transformation into a primitive, undifferentiated cell with abnormal longevity producing large numbers of white blood cells to be produced and enter the blood stream. http://purl.obolibrary.org/obo/DOID_12662 paracoccidioidomycosis http://purl.obolibrary.org/obo/DOID_9942 lymph node disease A primary systemic mycosis that results_in systemic fungal infection located_in mucosa, located_in lymph nodes, located_in bone, located_in skin or located_in lungs, has_material_basis_in Paracoccidioides brasiliensis. http://purl.obolibrary.org/obo/DOID_12663 blastomycosis http://purl.obolibrary.org/obo/DOID_0050292 primary systemic mycosis A primary systemic mycosis that results_in a systemic fungal infection, has_material_basis_in Blastomyces dermatitidis, transmitted_by airborne spores and has_symptom skin lesions, has_symptom lung lesions and has_symptom pleural thickening. http://purl.obolibrary.org/obo/DOID_12680 pseudobulbar palsy http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is characterized by damage to neurons of the corticobulbar tract, has_symptom dysarthria, has_symptom dysphagia, has_symptom spasticity located_in tongue, has_symptom abnormal bulbar reflexes, and has_symptom emotional outbursts. http://purl.obolibrary.org/obo/DOID_12683 vestibular neuronitis http://purl.obolibrary.org/obo/DOID_4953 poliomyelitis A inner ear infectious disease caused by a viral infection which involves inflammation of the vestibular nerve. It usually results as a complication of an upper respiratory infection. This causes sudden and severe vertigo, nausea and vomiting. Auditory symptoms are usually absent. http://purl.obolibrary.org/obo/DOID_12697 locked-in syndrome http://purl.obolibrary.org/obo/DOID_863 nervous system disease A nervous system disease that is characterized by complete paralysis of all voluntary muscles except for the ones that control the movements of the eyes. http://purl.obolibrary.org/obo/DOID_12698 gynecomastia http://purl.obolibrary.org/obo/DOID_1923 disorder of sexual development A disorder of sexual development that is characterized by enlargement or swelling of male breast tissue resulting from elevated male estrogen levels or imbalanced estrogen and testosterone levels. http://purl.obolibrary.org/obo/DOID_127 leiomyoma http://purl.obolibrary.org/obo/DOID_0060084 cell type benign neoplasm A cell type benign neoplasm that is a benign tumor of smooth muscle cells. http://purl.obolibrary.org/obo/DOID_1270 hereditary hemorrhagic telangiectasia http://purl.obolibrary.org/obo/DOID_178 vascular disease A vascular disease characterized by the presence of multiple arteriovenous malformations that lack intervening capillaries and result in direct connections between arteries and veins. http://purl.obolibrary.org/obo/DOID_12700 hyperprolactinemia http://purl.obolibrary.org/obo/DOID_0060158 acquired metabolic disease An acquired metabolic disease that has_material_basis_in the presence of abnormally-high levels of prolactin in the blood. http://purl.obolibrary.org/obo/DOID_12704 ataxia telangiectasia http://purl.obolibrary.org/obo/DOID_0050950 autosomal recessive cerebellar ataxia An autosomal recessive cerebellar ataxia that is characterized by cerebellar ataxia, telangiectases, immune defects, and a predisposition to malignancy and that has_material_basis_in homozygous or compound heterozygous mutation in the ATM gene on chromosome 11q22. http://purl.obolibrary.org/obo/DOID_1271 capillary disease http://purl.obolibrary.org/obo/DOID_178 vascular disease A vascular disease that is located_in the capillaries. http://purl.obolibrary.org/obo/DOID_12712 nephronophthisis http://purl.obolibrary.org/obo/DOID_557 kidney disease A kidney disease that is characterized by a chronic tubulointerstitial nephritis that progress to terminal renal failure during the second decade (juvenile form) or before the age of 5 years (infantile form) resulting from dysfunction of ciliary proteins (ciliopathy). http://purl.obolibrary.org/obo/DOID_12714 Ellis-Van Creveld syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by short limbs, short ribs, postaxial polydactyly, dysplastic nails and teeth, and in many patients congenital cardiac defects that has_material_basis_in homozygous or compound heterozygous mutation in either EVC or EVC2 on chromosome 4p16.2. http://purl.obolibrary.org/obo/DOID_12716 newborn respiratory distress syndrome http://purl.obolibrary.org/obo/DOID_11162 respiratory failure A respiratory failure that is characterized by deficiency of the surfactant coating the inner surface of the lungs, by failure of the lungs to expand and contract properly during breathing with resulting collapse, and by the accumulation of a protein-containing film lining the alveoli and their ducts. http://purl.obolibrary.org/obo/DOID_12721 multiple epiphyseal dysplasia http://purl.obolibrary.org/obo/DOID_2256 osteochondrodysplasia An osteochondrodysplasia that has_material_basis_in defective cartilage mineralization into bone which results in irregular ossification centers of the located in hip or located in knee. The disease has symptom fatigue, has symptom joint pain. http://purl.obolibrary.org/obo/DOID_1273 respiratory syncytial virus infectious disease http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in infection located_in upper respiratory tract or located_in lower respiratory tract, has_material_basis_in Human respiratory syncytial virus, which is transmitted_by droplet spread of nasal secretions from an infected person while coughing or sneezing, or transmitted_by contaminated fomites. The infection has_symptom runny nose, has_symptom fever, has_symptom cough, has_symptom wheezing, and has_symptom respiratory distress. http://purl.obolibrary.org/obo/DOID_12783 migraine without aura http://purl.obolibrary.org/obo/DOID_6364 migraine A migraine that is characterized by migraine headaches that are not accompanied by an aura. http://purl.obolibrary.org/obo/DOID_12798 mucopolysaccharidosis http://purl.obolibrary.org/obo/DOID_3211 lysosomal storage disease A lysosomal storage disease that involves the accumulation of glycosaminoglycans in the tissues and their excretion in the urine. http://purl.obolibrary.org/obo/DOID_12800 mucopolysaccharidosis VI http://purl.obolibrary.org/obo/DOID_12798 mucopolysaccharidosis A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme N-acetylgalactosamine 4-sulfatase. http://purl.obolibrary.org/obo/DOID_12801 mucopolysaccharidosis III http://purl.obolibrary.org/obo/DOID_12798 mucopolysaccharidosis A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme resulting in incomplete breakdown of the heparan sulfate sugar chain. http://purl.obolibrary.org/obo/DOID_12804 mucopolysaccharidosis IV http://purl.obolibrary.org/obo/DOID_12798 mucopolysaccharidosis A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzymes galactose 6-sulfate sulfatase (Type A) or beta-galactosidase (Type B) needed to break down the keratan sulfate sugar chain. http://purl.obolibrary.org/obo/DOID_1284 prolapse of female genital organ http://purl.obolibrary.org/obo/DOID_229 female reproductive system disease A female reproductive system disease that is characteried by the descent of one or more of the pelvic structures (bladder, uterus, vagina) from the normal anatomic location toward or through the vaginal opening. http://purl.obolibrary.org/obo/DOID_12841 ancylostomiasis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that involves infection of skin, eyes, and viscera in humans by the parasitic nematodes Ancylostoma braziliense, Ancylostoma ceylanicum, Ancylostoma duodenale or Ancylostoma caninum. The larvae cause lesions on the skin at the site of penetration. The infection has_symptom intestinal bleeding, has_symptom abdominal pain, has_symptom anemia, has_symptom severe diarrhea and has_symptom malnutrition. http://purl.obolibrary.org/obo/DOID_12842 Guillain-Barre syndrome http://purl.obolibrary.org/obo/DOID_0060033 autoimmune disease of peripheral nervous system An autoimmune disease of peripheral nervous system that causes body's immune system to attack part of the peripheral nervous system. http://purl.obolibrary.org/obo/DOID_12849 autistic disorder http://purl.obolibrary.org/obo/DOID_0060041 autism spectrum disorder An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years. http://purl.obolibrary.org/obo/DOID_12858 Huntington's disease http://purl.obolibrary.org/obo/DOID_1289 neurodegenerative disease A neurodegenerative disease that has_material_basis_in autosomal dominant inheritance and is characterized by unwanted choreatic movements, behavioral and psychiatric disturbances and dementia and has_material_basis_in expansion of CAG triplet repeats (glutamine) resulting in neuron degeneration affecting muscle coordination, cognitive abilities. http://purl.obolibrary.org/obo/DOID_1287 cardiovascular system disease http://purl.obolibrary.org/obo/DOID_7 disease of anatomical entity A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. http://purl.obolibrary.org/obo/DOID_12889 Miller Fisher syndrome http://purl.obolibrary.org/obo/DOID_12842 Guillain-Barre syndrome A Guillain-Barre syndrome that manifests as a descending paralysis. It usually affects the eye muscles first and presents with the triad of ophthalmoplegia, ataxia, and areflexia. http://purl.obolibrary.org/obo/DOID_1289 neurodegenerative disease http://purl.obolibrary.org/obo/DOID_331 central nervous system disease A central nervous system disease that results in the progressive deterioration of function or structure of neurons. http://purl.obolibrary.org/obo/DOID_12894 Sjogren's syndrome http://purl.obolibrary.org/obo/DOID_0060029 autoimmune disease of exocrine system An autoimmune disease that involves attack of immune cells which destroy the exocrine glands that produce tears and saliva. http://purl.obolibrary.org/obo/DOID_12900 Mikulicz disease http://purl.obolibrary.org/obo/DOID_417 autoimmune disease An autoimmune disease that is characterized by chronic enlargement of the glands of the head and neck, has_symptom lumps of the face and neck, dry eyes, dry mouth, and intermittent fever, and is often associated with an underlying autoimmune disorder, hematologic malignancy, tuberculosis infection, or syphilis infection. http://purl.obolibrary.org/obo/DOID_12929 endocardial fibroelastosis http://purl.obolibrary.org/obo/DOID_0050825 endocardium disease An endocardium disease that is characterized by a thickening of the inmost lining of the heart chambers due to an increase in the amount of supporting connective tissue and elastic fibers. http://purl.obolibrary.org/obo/DOID_12930 dilated cardiomyopathy http://purl.obolibrary.org/obo/DOID_0060036 intrinsic cardiomyopathy An intrinsic cardiomyopathy that is characterized by an an enlarged heart and damage to the myocardium causing the heart to pump blood inefficiently. http://purl.obolibrary.org/obo/DOID_1294 vulva carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A vulva cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. http://purl.obolibrary.org/obo/DOID_12960 acrocephalosyndactylia http://purl.obolibrary.org/obo/DOID_11971 synostosis A synostosis that results_in craniosynostosis and syndactyly. http://purl.obolibrary.org/obo/DOID_12969 central nervous system leukemia http://purl.obolibrary.org/obo/DOID_3620 central nervous system cancer A hematologic cancer located_in the central nervous system. http://purl.obolibrary.org/obo/DOID_12971 hereditary spherocytosis http://purl.obolibrary.org/obo/DOID_589 congenital hemolytic anemia A congenital hemolytic anemia characterized by the production of red blood cells with a sphere shape, rather than the normal biconcave disk shape. http://purl.obolibrary.org/obo/DOID_12987 agranulocytosis http://purl.obolibrary.org/obo/DOID_615 leukopenia A leukopenia that is characterized by a severe lack of of granulocytes with a drop in granulocyte concentration below 200 cells/mm³ of blood. http://purl.obolibrary.org/obo/DOID_12995 conduct disorder http://purl.obolibrary.org/obo/DOID_0060038 specific developmental disorder A specific developmental disorder marked by a pattern of repetitive behavior wherein the rights of others or social norms are violated. http://purl.obolibrary.org/obo/DOID_13027 transient global amnesia http://purl.obolibrary.org/obo/DOID_10914 amnestic disorder An amnestic disorder that is characterized by temporary but almost total disruption of short-term memory with a range of problems accessing older memories. http://purl.obolibrary.org/obo/DOID_13034 relapsing fever http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that results_in infection, has_material_basis_in Borrelia, which is transmitted_by tick or transmitted_by body louse. http://purl.obolibrary.org/obo/DOID_13036 tick-borne relapsing fever http://purl.obolibrary.org/obo/DOID_13034 relapsing fever A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia hermsii, has_material basis_in Borrelia parkeri or has_material basis_in Borrelia duttoni, which are transmitted_by soft ticks (Ornithodoros parkeri and Ornithodoros hermsii). The infection has_symptom tachypnea, has_symptom tachycardia, has_symptom hepatosplenomegaly and has_symptom lymphadenopathy. http://purl.obolibrary.org/obo/DOID_1307 dementia http://purl.obolibrary.org/obo/DOID_1561 cognitive disorder A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior. http://purl.obolibrary.org/obo/DOID_13074 tinea unguium http://purl.obolibrary.org/obo/DOID_8913 dermatophytosis A dermatophytosis that results_in fungal infection located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which cause separation of the nail plate from the nail bed and has_symptom thickening of subungueal area. Sometimes, white islands are seen on the external nail plates. These gradually coalesce until the entire nail plate is involved. http://purl.obolibrary.org/obo/DOID_13078 eumycotic mycetoma http://purl.obolibrary.org/obo/DOID_1563 dermatomycosis A dermatomycosis that effects skin and subcutaneous tissue located in foot, located in trunk, located in buttocks, located in eyelids, located in lacrimal glands, located in paranasal sinuses, located in mandible, located in scalp, located in neck, located in perineum, or located in testes and has symptom sinus discharge and results in formation of nodules. http://purl.obolibrary.org/obo/DOID_13098 central retinal artery occlusion http://purl.obolibrary.org/obo/DOID_8483 retinal artery occlusion A retinal artery occlusion characterized by blockage of blood flow through the central retinal artery. http://purl.obolibrary.org/obo/DOID_13099 Moyamoya disease http://purl.obolibrary.org/obo/DOID_3527 cerebral arterial disease A cerebral arterial disease characterized by constriction of certain arteries at the base of the brain. Blood flow is blocked by the constriction and also by blood clots. http://purl.obolibrary.org/obo/DOID_13109 bladder leiomyoma http://purl.obolibrary.org/obo/DOID_127 leiomyoma A bladder benign neoplasm that derives_from smooth muscle cells. http://purl.obolibrary.org/obo/DOID_13137 Werdnig-Hoffmann disease http://purl.obolibrary.org/obo/DOID_0060160 childhood spinal muscular atrophy A childhood spinal muscular atrophy that is a severe form and is characterized by muscle weakness onset from birth to six months of age, the inability to sit unassisted. http://purl.obolibrary.org/obo/DOID_13141 uveitis http://purl.obolibrary.org/obo/DOID_3480 uveal disease An uveal disease is characterized by inflammation of any of the layers of the uvea of the eye, which includes the iris, ciliary body, and choroid. http://purl.obolibrary.org/obo/DOID_13189 gout http://purl.obolibrary.org/obo/DOID_848 arthritis An arthritis that has_material_basis_in uric acid crystal deposits located_in joint. http://purl.obolibrary.org/obo/DOID_1319 brain cancer http://purl.obolibrary.org/obo/DOID_936 brain disease A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain. http://purl.obolibrary.org/obo/DOID_13223 uterine fibroid http://purl.obolibrary.org/obo/DOID_0060095 uterine benign neoplasm An uterine benign neoplasm derived from the smooth muscle layer of the uterus. http://purl.obolibrary.org/obo/DOID_1324 lung cancer http://purl.obolibrary.org/obo/DOID_850 lung disease A respiratory system cancer that is located_in the lung. http://purl.obolibrary.org/obo/DOID_1325 bronchus cancer http://purl.obolibrary.org/obo/DOID_1176 bronchial disease A respiratory system cancer that is located_in the bronchus. http://purl.obolibrary.org/obo/DOID_13250 diarrhea http://purl.obolibrary.org/obo/DOID_77 gastrointestinal system disease A gastrointestinal system disease described as the condition of having frequent loose or liquid bowel movements. Acute diarrhea is a common cause of death in developing countries and the second most common cause of infant deaths worldwide. The loss of fluids through diarrhea can cause severe dehydration which is one cause of death in diarrhea sufferers. Along with water, sufferers also lose dangerous amounts of important salts, electrolytes, and other nutrients. There are at least four types of diarrhea: secretory diarrhea, osmotic diarrhea, motility-related diarrhea, and inflammatory diarrhea. http://purl.obolibrary.org/obo/DOID_13258 typhoid fever http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that is a communicable systemic illness, has_material_basis_in Salmonella enterica subsp enterica serovar Typhi, which is transmitted_by ingestion of food or water contaminated with the feces of an infected person. The infection has_symptom fever, has_symptom diarrhea, has_symptom prostration, has_symptom headache, has_symptom splenomegaly, has_symptom liver enlargement, has_symptom eruption of rose-colored spots, and has_symptom leukopenia. http://purl.obolibrary.org/obo/DOID_13268 porphyria http://purl.obolibrary.org/obo/DOID_655 inherited metabolic disorder An inherited metabolic disorder that involves certain enzymes in the heme bio-synthetic pathway resulting in the overproduction and accumulation of the porphyrins. http://purl.obolibrary.org/obo/DOID_13270 erythropoietic protoporphyria http://purl.obolibrary.org/obo/DOID_3133 acute porphyria An acute porphyria characterized by a deficiency in the enzyme ferrochelatase, leading to abnormally high levels of protoporphyrin in the tissue. http://purl.obolibrary.org/obo/DOID_1328 Rift Valley fever http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in infection, has_material_basis_in Rift Valley fever virus, which is transmitted_by Aedes mosquitoes. The virus affects domestic animals (cattle, buffalo, sheep, goats, and camels) and humans. The infection has_symptom jaundice, has_symptom vomiting blood, has_symptom passing blood in the feces, has_symptom ecchymoses (caused by bleeding in the skin), has_symptom bleeding from the nose or gums, has_symptom menorrhagia and has_symptom bleeding from venepuncture sites. http://purl.obolibrary.org/obo/DOID_13282 intestinal tuberculosis http://purl.obolibrary.org/obo/DOID_5295 intestinal disease A gastrointestinal tuberculosis that involves diffuse mucosal fold thickening, formation of ulcers and fistulae located_in intestine. The infection has_symptom abdominal pain, has_symptom gastrointestinal bleeding, has_symptom nausea and has_symptom vomiting. http://purl.obolibrary.org/obo/DOID_13300 Scheuermann's disease http://purl.obolibrary.org/obo/DOID_8125 osteochondrosis An osteochondrosis that results_in abnormal bone growth and curvature located_in thoracic vertebral column. http://purl.obolibrary.org/obo/DOID_13317 hyperinsulinemic hypoglycemia http://purl.obolibrary.org/obo/DOID_2978 carbohydrate metabolic disorder A carbohydrate metabolic disorder that involves low blood glucose resulting from an excess of insulin. http://purl.obolibrary.org/obo/DOID_13328 diabetic cataract http://purl.obolibrary.org/obo/DOID_83 cataract A cataract that is characterized by loss of lens transparency secondary to hyperglycemia related to diabetes mellitus. http://purl.obolibrary.org/obo/DOID_13336 congenital toxoplasmosis http://purl.obolibrary.org/obo/DOID_9965 toxoplasmosis A toxoplasmosis that involves a reactivated infection of the mother transmitted to the fetus during pregnancy. Spontaneous abortion and stillbirth may occur. http://purl.obolibrary.org/obo/DOID_13359 Ehlers-Danlos syndrome http://purl.obolibrary.org/obo/DOID_854 collagen disease A collagen disease that is characterized by extremely flexible joints, elastic skin, and excessive bruising caused by a heritable defect in collagen synthesis, which leads to marked healing difficulties. EDS has five cardinal signs, which may be present to some degree in all of the subtypes. These five cardinal signs are skin fragility, blood vessel fragility, skin hyperelasticity, joint hypermobility, and characteristic subcutaneous nodules. http://purl.obolibrary.org/obo/DOID_13365 reading disorder http://purl.obolibrary.org/obo/DOID_8927 learning disability A learning disability involing difficulty reading resulting primarily from neurological factors which affect any part of the reading process. http://purl.obolibrary.org/obo/DOID_13366 Stiff-Person syndrome http://purl.obolibrary.org/obo/DOID_480 movement disease A movement disease that is of unknown etiology characterized by progressive rigidity. http://purl.obolibrary.org/obo/DOID_13369 tinea manuum http://purl.obolibrary.org/obo/DOID_8913 dermatophytosis A dermatophytosis that results_in fungal skin infection located_in hand, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching, has_symptom burning, has_symptom cracking, and has_symptom scaling. http://purl.obolibrary.org/obo/DOID_13371 scrub typhus http://purl.obolibrary.org/obo/DOID_11256 typhus A typhus that has_material_basis_in Orientia tsutsugamushi, which is transmitted by trombiculid mites (Leptotrombidium deliense). The infection has symptom fever, has symptom headache, has symptom muscle pain, has symptom cough, has symptom maculopapular rash, has symptom eschar, has symptom splenomegaly and has symptom lymphadenopathy. http://purl.obolibrary.org/obo/DOID_13372 alpha 1-antitrypsin deficiency http://purl.obolibrary.org/obo/DOID_2345 plasma protein metabolism disease A plasma protein metabolism disease that has_material_basis_in defective production of the protease inhibitor alpha 1-antitrypsin (A1AT), leading to decreased A1AT activity in the blood and lungs, and deposition of excessive abnormal A1AT protein in liver cells. http://purl.obolibrary.org/obo/DOID_13374 fibrodysplasia ossificans progressiva http://purl.obolibrary.org/obo/DOID_65 connective tissue disease A connective tissue disease that is characterized by progressive ossification of skeletal muscle, fascia, tendons, and ligaments and has_material_basis_in heterozygous mutation in the ACVR1 gene. http://purl.obolibrary.org/obo/DOID_13378 Kawasaki disease http://purl.obolibrary.org/obo/DOID_1602 lymphadenitis A lymphadenitis characterized by swelling of cervical lymph nodes in infants and young children and inflammation of medium-sized blood vessels located_in body, has_symptom fever, has_symptom congestion of ocular conjunctivae, has_symptom reddening of lips, has_symptom reddening of oral cavity, has_symptom protuberance of tongue papillae and has_symptom edema of extremities. http://purl.obolibrary.org/obo/DOID_1338 congenital dyserythropoietic anemia http://purl.obolibrary.org/obo/DOID_589 congenital hemolytic anemia A congenital hemolytic anemia characterized by ineffective erythropoiesis, and resulting from a decrease in the number of red blood cells (RBCs) in the body and a less than normal quantity of hemoglobin in the blood. http://purl.obolibrary.org/obo/DOID_13381 pernicious anemia http://purl.obolibrary.org/obo/DOID_5113 nutritional deficiency disease A nutritional deficiency disease that is characterized by a decrease in red blood cells due to malabsorption of vitamin B12, has_symptom fatigue, pallor, shortness of breath, glossitis, ataxia, and/or paresthesia, has_material_basis_in atrophic gastritis, autoimmune disorder affecting the production or function of intrinsic factor, and/or genetic factors. http://purl.obolibrary.org/obo/DOID_13382 megaloblastic anemia http://purl.obolibrary.org/obo/DOID_2361 macrocytic anemia A macrocytic anemia that is characterized by inhibition of DNA synthesis during red blood cell production. http://purl.obolibrary.org/obo/DOID_1339 Diamond-Blackfan anemia http://purl.obolibrary.org/obo/DOID_1342 congenital hypoplastic anemia A congenital hypoplastic anemia that is characterized by anemia (low red blood cell counts) with decreased erythroid progenitors in the bone marrow and has_material_basis_insufficient levels of red blood cells due to bone marrow dysfunction. http://purl.obolibrary.org/obo/DOID_13399 color blindness http://purl.obolibrary.org/obo/DOID_1432 blindness A blindness that is characterized by the inability or decreased ability to see color, or perceive color differences, under normal lighting conditions. http://purl.obolibrary.org/obo/DOID_13405 cardiac sarcoidosis http://purl.obolibrary.org/obo/DOID_11335 sarcoidosis A sarcoidosis that is characterized by conduction abnormalities, arrhythmias, and congestive heart failure with noncaseating granulomas present on endomyocardial biopsy, and develops_from a type IV hypersensitivity reaction with noncaseating granulomas infiltrating the myocardial tissue, especially that of the left ventricle. http://purl.obolibrary.org/obo/DOID_13413 hepatic encephalopathy http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is characterized by loss of brain function, the occurrence of confusion, altered level of consciousness, and coma that results when the liver is unable to remove toxins from the blood. http://purl.obolibrary.org/obo/DOID_13444 glanders http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that results in septicemic infection, has_material_basis_in Burkholderia mallei, which is transmitted by contact with tissues or body fluids of infected animals, or through mucosal surfaces such as the eyes and nose. The infection has symptom fever, has symptom chills, has symptom sweating, has symptom muscle aches, has symptom chest pain, has symptom muscle tightness, has symptom headache, has symptom mucopurulent nasal discharge, and has symptom nodular lesions in the lungs. http://purl.obolibrary.org/obo/DOID_13450 coccidioidomycosis http://purl.obolibrary.org/obo/DOID_0050292 primary systemic mycosis A primary systemic mycosis that results_in systemic fungal infection, has_material_basis_in Coccidioides immitis, transmitted_by airborne spores and has_symptom conjunctivitis, has_symptom arthritis, has_symptom chest pain and results_in_formation_of skin nodules. http://purl.obolibrary.org/obo/DOID_13477 balanitis xerotica obliterans http://purl.obolibrary.org/obo/DOID_13033 balanitis A balantitis characterized by white plaques or patches on genitals. http://purl.obolibrary.org/obo/DOID_13481 thanatophoric dysplasia http://purl.obolibrary.org/obo/DOID_2256 osteochondrodysplasia An osteochondrodysplasia that results_in short arms and legs with excess folds of skin. http://purl.obolibrary.org/obo/DOID_13482 Proteus syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by overgrowth of the bones, skin, and other tissues. http://purl.obolibrary.org/obo/DOID_13487 childhood disintegrative disease http://purl.obolibrary.org/obo/DOID_0060040 pervasive developmental disorder A pervasive developmental disorder that is a rare condition characterized by late onset (greater than 3 years of age) of developmental delays in language, social function, and motor skills where children who have had previously normal development who then appear to regress. http://purl.obolibrary.org/obo/DOID_13501 Mobius syndrome http://purl.obolibrary.org/obo/DOID_1756 facial nerve disease A facial nerve disease characterized by congenital, uni- or bilateral, non-progressive facial weakness and limited abduction of the eye(s). http://purl.obolibrary.org/obo/DOID_13515 tuberous sclerosis http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by the growth of numerous noncancerous tumors in many parts of the body. http://purl.obolibrary.org/obo/DOID_13521 tetanus neonatorum http://purl.obolibrary.org/obo/DOID_11338 tetanus A tetanus that occurs in newborn babies when the birth cord stump gets dirty through cutting it with an unclean blade or applying substances containing bacteria to it. The infection has symptom stiff body, has symptom muscle spasms, has symptom difficulty in breathing, and has symptom exhaustion. http://purl.obolibrary.org/obo/DOID_13523 loiasis http://purl.obolibrary.org/obo/DOID_5614 eye disease A filariasis that involves parasitic infection of the skin and eyes caused by the nematode Loa loa, which is transmitted through the bite of a deer fly or mango fly. The disease is characterized by episodic angioedema in the arms and legs, and cyst-like enlargements of the connective tissue around the sheaths of muscle tendons. Dead worms may cause chronic abscesses, which may lead to the formation of granulomatous reactions and fibrosis. http://purl.obolibrary.org/obo/DOID_13533 osteopetrosis http://purl.obolibrary.org/obo/DOID_4254 osteosclerosis An osteosclerosis that has_material_basis_in lack of bone resorption which results_in abnormally hard and brittle bones. http://purl.obolibrary.org/obo/DOID_13543 hyperparathyroidism http://purl.obolibrary.org/obo/DOID_11201 parathyroid gland disease A parathyroid gland disease characterized by an overactivity of the parathyroid glands, leading to an excess of parathyroid hormone in the body. http://purl.obolibrary.org/obo/DOID_13544 low tension glaucoma http://purl.obolibrary.org/obo/DOID_1067 open-angle glaucoma An open-angle glaucoma characterized by increased intrinsic resistance to aqueous outflow without known secondary causes, an anatomically narrow anterior chamber angle, or elevated intraocular pressure compared to the average population. Normal tension glaucoma has_symptom progressive decreased vision and progressive loss of peripheral vision. http://purl.obolibrary.org/obo/DOID_13549 interval angle-closure glaucoma http://purl.obolibrary.org/obo/DOID_1405 primary angle-closure glaucoma A primary angle-closure glaucoma characterized by acute closure of the anterior chamber angle by an intrinsic defect such that aqueous outflow is blocked and the intraocular pressure becomes suddenly inappropriately elevated threatening optic nerve damage and visual field loss; but that typically resolves spontaneously after several hours, even though it may recur. Interval angle-closure glaucoma has_symptom sudden pain, redness, headache, and blurry vision with haloes around lights that resolves spontaneously. Interval angle-closure glaucoma can be caused by exacerbation of chronic primary angle-closure glaucoma, typically by a medication or state that dilates the eyes and thus narrows the anterior chamber angle, blocking any aqueous outflow. http://purl.obolibrary.org/obo/DOID_13550 angle-closure glaucoma http://purl.obolibrary.org/obo/DOID_1686 glaucoma A glaucoma characterized by closure of the anterior chamber angle such that aqueous outflow is blocked and the intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Angle-closure glaucoma has_symptom progressive peripheral vision loss, decreased vision, and pain, redness, and headache in acute cases. Angle closure glaucoma can be caused by anatomically narrow angle, injury to the trabecular meshwork, and injuries to the anterior chamber, such as neovascularization and uveitis. http://purl.obolibrary.org/obo/DOID_13564 aspergillosis http://purl.obolibrary.org/obo/DOID_2473 opportunistic mycosis An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney, heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system. http://purl.obolibrary.org/obo/DOID_13580 cholestasis http://purl.obolibrary.org/obo/DOID_4138 bile duct disease A bile duct disease that is characterized by where bile cannot flow from the liver to the duodenum. http://purl.obolibrary.org/obo/DOID_13593 eclampsia http://purl.obolibrary.org/obo/DOID_10591 pre-eclampsia A pre-eclampsia characterized by the presence of seizures. http://purl.obolibrary.org/obo/DOID_13608 biliary atresia http://purl.obolibrary.org/obo/DOID_13580 cholestasis A cholestasis characterized by blockage of the ducts that carry bile from the liver to the gallbladder. http://purl.obolibrary.org/obo/DOID_13622 campylobacteriosis http://purl.obolibrary.org/obo/DOID_104 bacterial infectious disease A primary bacterial infectious disease that results_in infection located_in intestine, has_material_basis_in Campylobacter jejuni, which is transmitted_by ingestion of contaminated food or water or transmitted_by contact with infected people or animals. The infection has_symptom diarrhea or has_symptom dysentery, has_symptom abdominal cramps and pain, and has_symptom fever. http://purl.obolibrary.org/obo/DOID_13628 favism http://purl.obolibrary.org/obo/DOID_2862 glucosephosphate dehydrogenase deficiency A glucosephosphate dehydrogenase deficiency characterized by a hemolytic reaction to consumption of broad beans. http://purl.obolibrary.org/obo/DOID_13636 Fanconi anemia http://purl.obolibrary.org/obo/DOID_1342 congenital hypoplastic anemia A congenital hypoplastic anemia characterized by progressive pancytopenia with bone marrow failure, variable congenital malformations and predisposition to develop hematological or solid tumors. It is a result of a genetic defect in a cluster of proteins responsible for DNA repair. http://purl.obolibrary.org/obo/DOID_13641 exfoliation syndrome http://purl.obolibrary.org/obo/DOID_240 iris disease A phacogenic glaucoma that is characterized by open-angle glaucoma related to deposition of extracellular fibrillar material in anterior segment structures, which blocks aqueous fluid outflow, raises intraocular pressure, and leads to eventual optic nerve atrophy and visual field loss. Exfoliation syndrome has_symptom progressive decreased vision, especially peripheral vision. Exfoliation syndrome is caused by age-related deposition of fibrillar material in anterior segment structures. http://purl.obolibrary.org/obo/DOID_13717 mature cataract http://purl.obolibrary.org/obo/DOID_9669 senile cataract A senile cataract that is characterized by full white or brunescent opacification of the lens of the eye such that the red reflex is obscured. It is a later stage of senile cataracts and is caused by a multifactorial etiology related to aging. http://purl.obolibrary.org/obo/DOID_13722 neuroschistosomiasis http://purl.obolibrary.org/obo/DOID_936 brain disease A schistosomiasis that involves parasitic infection of the brain and spinal cord by Schistosoma haematobium, Schistosoma mansoni or Schistosoma japonicum causing acute or subacute myelopathy, focal central nervous system impairment, seizures and increased intracranial pressure. http://purl.obolibrary.org/obo/DOID_13724 scurvy http://purl.obolibrary.org/obo/DOID_5113 nutritional deficiency disease A nutritional deficiency disease that is characterized by vitamin C (ascorbic acid) deficiency and has_symptom fatigue, weakness, anemia, petechiae, corkscrew hair, gingivitis, and poor wound healing. http://purl.obolibrary.org/obo/DOID_13725 beriberi http://purl.obolibrary.org/obo/DOID_0070313 thiamine deficiency disease A thiamine deficiency disease that is characterized by being severe and chronic. http://purl.obolibrary.org/obo/DOID_1373 endometrial stromal nodule http://purl.obolibrary.org/obo/DOID_0060095 uterine benign neoplasm An uterine benign neoplasm that has_material_basis_in cells reminiscent of proliferative phase endometrial stroma. http://purl.obolibrary.org/obo/DOID_13760 Pthirus pubis infestation http://purl.obolibrary.org/obo/DOID_5502 lice infestation A lice infestation that involves parasitic infestation by pubic lice Pthirus pubis, which are found in the pubic hair, less commonly in eyebrows, eyelashes, beard, mustache, armpit, perianal area, groin, trunk and scalp. The symptoms include itching in the pubic and groin area. Intense itching leads to scratching which can cause sores and secondary bacterial infection of the skin. http://purl.obolibrary.org/obo/DOID_13767 clonorchiasis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that involves parasitic infection of the bile ducts of the liver by Clonorchis sinensis. The symptoms include abdominal pain, nausea, diarrhea, and eosinophilia. In long-standing infections, cholangitis, cholelithiasis, pancreatitis, and cholangiocarcinoma can develop. http://purl.obolibrary.org/obo/DOID_13768 opisthorchiasis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that involves parasitic infection of the liver, pancreas and gall bladder by Opisthorchis viverrini or Opisthorchis felineus. The symptoms include dyspepsia, abdominal pain, diarrhea, constipation, hepatomegaly, cholangitis, cholecystitis, and chlolangiocarcinoma. http://purl.obolibrary.org/obo/DOID_13774 Addison's disease http://purl.obolibrary.org/obo/DOID_10493 adrenal cortical hypofunction An adrenal cortical hypofunction that is characterized by insufficient steroid hormone production by the adrenal glands. http://purl.obolibrary.org/obo/DOID_13777 epidermodysplasia verruciformis http://purl.obolibrary.org/obo/DOID_612 primary immunodeficiency disease A primary immunodeficiency disease that results_in skin squamous cell carcinoma located_in skin, associated with a high risk of carcinoma. It is characterized by abnormal susceptibility to human papillomaviruses of the skin and has_symptom lesions on the body. http://purl.obolibrary.org/obo/DOID_13778 chancroid http://purl.obolibrary.org/obo/DOID_37 skin disease A primary bacterial infectious disease that is a sexually transmitted infection located in skin of the genitals, has_material_basis_in Haemophilus ducreyi, which is transmitted by sexual contact. The infection has symptom painful and soft ulcers. http://purl.obolibrary.org/obo/DOID_1380 endometrial cancer http://purl.obolibrary.org/obo/DOID_363 uterine cancer A uterine cancer that is located_in tissues lining the uterus. http://purl.obolibrary.org/obo/DOID_13800 inclusion conjunctivitis http://purl.obolibrary.org/obo/DOID_4251 conjunctival disease A commensal bacterial infectious disease that results_in inflammation, located_in conjunctiva of the eye, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact. The infection has_symptom swollen conjunctiva and eyelids and has_symptom discharge of pus and mucus. http://purl.obolibrary.org/obo/DOID_1381 Fox-Fordyce disease http://purl.obolibrary.org/obo/DOID_1383 sweat gland disease A sweat gland disease that is characterized by dilatation of the follicular infundibulum with hyperkeratosis, acanthosis, and spongiosis with perifollicular inflammation leading to hair loss and has_symptom flesh colored papules with hair loss and pruritis, especially of the axilla. http://purl.obolibrary.org/obo/DOID_13819 lymphogranuloma venereum http://purl.obolibrary.org/obo/DOID_9113 granuloma inguinale A commensal bacterial infectious disease that results_in infection located_in lymph nodes, has_material_basis_in Chlamydia trachomatis, which is transmitted_by sexual contact, and transmitted_by fomites. The infection has_symptom inguinal lymphadenitis, has_symptom abscesses in the groin area, and has_symptom lymphangitis. http://purl.obolibrary.org/obo/DOID_1382 miliaria http://purl.obolibrary.org/obo/DOID_1383 sweat gland disease A sweat gland disease that is characterized by blocked eccrine sweat glands and ducts. http://purl.obolibrary.org/obo/DOID_1383 sweat gland disease http://purl.obolibrary.org/obo/DOID_37 skin disease A skin disease located_in the sweat glands. http://purl.obolibrary.org/obo/DOID_1386 abetalipoproteinemia http://purl.obolibrary.org/obo/DOID_1387 hypolipoproteinemia A hypolipoproteinemia that is characterized by an inablility to fully absorb dietary fats, cholesterol and fat-soluble vitamins, has_material_basis_in an autosomal recessive disorder of lipid metabolism that has_material_basis_in mutation in the microsomal triglyceride transfer protein that catalyzes the transport of lipids and is required in the secretion of BETA-LIPOPROTEINS. http://purl.obolibrary.org/obo/DOID_13862 acute closed-angle glaucoma http://purl.obolibrary.org/obo/DOID_1405 primary angle-closure glaucoma A primary angle-closure glaucoma characterized by acute closure of the anterior chamber angle by an intrinsic defect such that aqueous outflow is blocked and the intraocular pressure becomes suddenly inappropriately elevated threatening futher optic nerve damage and visual field loss. Acute closed-angle glaucoma has_symptom sudden pain, redness, headache, and blurry vision with haloes around lights. Acute closed-angle glaucoma can be caused by exacerbation of chronic primary angle-closure glaucoma, typically by a medication or state that dilates the eyes and thus narrows the anterior chamber angle, blocking any aqueous outflow. http://purl.obolibrary.org/obo/DOID_1389 polyneuropathy http://purl.obolibrary.org/obo/DOID_574 peripheral nervous system disease A peripheral system disease that is characterized by damage affecting peripheral nerves (peripheral neuropathy) in roughly the same areas on both sides of the body, featuring weakness, numbness, pins-and-needles, and burning pain. http://purl.obolibrary.org/obo/DOID_1390 hypobetalipoproteinemia http://purl.obolibrary.org/obo/DOID_1387 hypolipoproteinemia A hypolipoproteinemia characterized by permanently low levels of apolipoprotein B and LDL cholesterol resulting from an impaired ability to absorb and transport fats. http://purl.obolibrary.org/obo/DOID_13911 achromatopsia http://purl.obolibrary.org/obo/DOID_13399 color blindness A color blindness that is characterized by a congenital cone color vision disorder, the inability to perceive color and to achieve satisfactory visual acuity at high light levels has_material_basis_in autosomal recessive inheritance. http://purl.obolibrary.org/obo/DOID_13922 eosinophilic esophagitis http://purl.obolibrary.org/obo/DOID_11963 esophagitis An esophagitis characterized by inflammation involving eosinophils located_in esophagus. http://purl.obolibrary.org/obo/DOID_1393 visual pathway disease http://purl.obolibrary.org/obo/DOID_5614 eye disease An eye disease that affects the neural pathway from the optic nerve to the visual cortex, through which light is interpreted as an image. http://purl.obolibrary.org/obo/DOID_13938 amenorrhea http://purl.obolibrary.org/obo/DOID_229 female reproductive system disease A female reproductive system disease that is characterized by the absence of menstruation. http://purl.obolibrary.org/obo/DOID_1394 urinary schistosomiasis http://purl.obolibrary.org/obo/DOID_365 bladder disease A schistosomiasis that involves parasitic infection of the urinary tract caused by a digenetic trematode Schistosoma haematobium causing cystitis, ureteritis, fibrosis of the bladder and haematuria, which can progress to bladder cancer. http://purl.obolibrary.org/obo/DOID_13945 CADASIL http://purl.obolibrary.org/obo/DOID_10579 leukodystrophy A leukodystrophy characterized by recurrent subcortical ischemic stroke and cognitive impairment. http://purl.obolibrary.org/obo/DOID_1395 schistosomiasis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that involves infection of the intestine, urinary tract, skin, liver and spleen caused by multiple species of the trematode fluke of the genus Schistosoma. The symptoms include fever, chills, nausea, abdominal pain, diarrhea, malaise, myalgia, liver and spleen enlargement, rash and hematuria. http://purl.obolibrary.org/obo/DOID_13964 Morgagni cataract http://purl.obolibrary.org/obo/DOID_9669 senile cataract A senile cataract that is characterized by dense white opacification of the lens and milky fluid in the lens capsule such that the dense nucleus of the lens sinks in the surrounding fluid. It is the late stage of senile cataracts and is caused by a multifactorial etiology related to aging. http://purl.obolibrary.org/obo/DOID_1398 parasitic infectious disease http://purl.obolibrary.org/obo/DOID_0050117 disease by infectious agent A disease by infectious agent that is carried out by a parasite which by definition is a pathogen that simultaneously injures and derives sustenance from its host. http://purl.obolibrary.org/obo/DOID_13994 cleidocranial dysplasia http://purl.obolibrary.org/obo/DOID_2256 osteochondrodysplasia An osteochondrodysplasia that has_material_basis_in mutations in the RUNX2 gene which results_in undeveloped or absent located_in clavicle along with delayed closing of fontanels in the located_in skull. http://purl.obolibrary.org/obo/DOID_1400 lacrimal apparatus disease http://purl.obolibrary.org/obo/DOID_5614 eye disease An eye disease that affects the lacrimal apparatus (the lacrimal gland and its related structures) which moisten and drain the eye. http://purl.obolibrary.org/obo/DOID_14026 folic acid deficiency anemia http://purl.obolibrary.org/obo/DOID_5113 nutritional deficiency disease A nutritional deficiency disease that is characterized by a decrease in red blood cells due to lack of folate, has_material_basis in insufficient folic acid in diet, hemolytic anemia, alcoholism, and/or certain medicines. http://purl.obolibrary.org/obo/DOID_14039 POEMS syndrome http://purl.obolibrary.org/obo/DOID_620 blood protein disease A blood protein disease that is characterized by polyneuropathy, oranomegaly, endocrinopathy, monoclonal gammopathy, and skin changes, especially hyperpigmentation. http://purl.obolibrary.org/obo/DOID_14040 autoimmune polyendocrine syndrome http://purl.obolibrary.org/obo/DOID_0060005 autoimmune disease of endocrine system An autoimmune disease of endocrine system characterized by abnormal functioning of the immune system that causes auto-reactivity against endocrine organs. http://purl.obolibrary.org/obo/DOID_14042 bipolar I disorder http://purl.obolibrary.org/obo/DOID_3312 bipolar disorder A bipolar disorder that is characterized by at least one manic or mixed episode. http://purl.obolibrary.org/obo/DOID_14049 phaeohyphomycosis http://purl.obolibrary.org/obo/DOID_936 brain disease A primary systemic mycosis located_in subcutaneous tissues, located_in brain, located_in sinuses, located_in lungs, or located_in peritoneal cavity, has_material_basis_in Exophiala dermatitidis, has_material_basis_in Phialophora, has_material_basis_in Bipolaris hawaiiensis, has_material_basis_in Exserohilum, has_material_basis_in Cladophialophora bantiana, has_material_basis_in Phaeoannellomyces, has_material_basis_in Aureobasidium, has_material_basis_in Cladosporium cladosporoides, has_material_basis_in Alternaria or has_material_basis_in Rhinocladiella mackenziei and results_in_formation_of subcutaneous abscesses arising at the site of minor trauma, and occur in both immunosuppressed and immunocompetent individuals. http://purl.obolibrary.org/obo/DOID_1405 primary angle-closure glaucoma http://purl.obolibrary.org/obo/DOID_13550 angle-closure glaucoma An angle-closure glaucoma characterized by closure of the anterior chamber angle by an intrinsic defect such that aqueous outflow is blocked and the intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Primary angle-closure glaucoma has_symptom progressive peripheral vision loss, decreased vision, and pain, redness, and headache in acute cases. Primary angle closure glaucoma can be caused by anatomically narrow angle, defects in the trabecular meshwork, and iris abnormalities. Primary angle-closure glaucoma has a strong genetic component. http://purl.obolibrary.org/obo/DOID_14068 blackwater fever http://purl.obolibrary.org/obo/DOID_12365 malaria A malaria that presents as a rare febrile complication of repeated malarial attacks characterized by intravascular haemolysis, haemoglobinuria and kidney failure, resulting from destruction of red blood cells caused by heavy parasitization with Plasmodium falciparum or Plasmodium vivax. http://purl.obolibrary.org/obo/DOID_14087 epicondylitis http://purl.obolibrary.org/obo/DOID_3342 bone inflammation disease A bone inflammation disease that results_in inflammation located_in epicondyle. http://purl.obolibrary.org/obo/DOID_14095 boutonneuse fever http://purl.obolibrary.org/obo/DOID_11104 spotted fever A spotted fever that has_material_basis_in Rickettsia conorii subsp conorii, which is transmitted_by dog tick (Rhipicephalus sanguineus). The infection has_symptom fever, has_symptom eschar (usually single), has_symptom regional adenopathy, has_symptom maculopapular rash on extremities. http://purl.obolibrary.org/obo/DOID_14110 anus cancer http://purl.obolibrary.org/obo/DOID_5672 large intestine cancer A large intestine cancer that is located_in the anus. http://purl.obolibrary.org/obo/DOID_14115 toxic shock syndrome http://purl.obolibrary.org/obo/DOID_0050339 commensal bacterial infectious disease A commensal bacterial infectious disease that results_in infection, has_material_basis_in Streptococcus pyogenes or has_material_basis_in Staphylococcus aureus , which produce toxins that are absorbed systemically and produce the systemic manifestations. The infection has_symptom fever, has_symptom rash, has_symptom hypotension, has_symptom multiorgan failure, has_symptom desquamation, has_symptom vomiting, has_symptom diarrhea, has_symptom headache, and has_symptom nonfocal neurologic abnormalities. http://purl.obolibrary.org/obo/DOID_14118 familial lipoprotein lipase deficiency http://purl.obolibrary.org/obo/DOID_0111417 familial chylomicronemia syndrome A familial hyperlipemia characterized by a deficiency of the enzyme lipoprotein lipase and the subsequent build up of chylomicrons and increased plasma concentration of triglycerides. http://purl.obolibrary.org/obo/DOID_1412 bacteriuria http://purl.obolibrary.org/obo/DOID_18 urinary system disease A urinary system disease which consists of the presence of bacteria in urine. http://purl.obolibrary.org/obo/DOID_14130 lateral cystocele http://purl.obolibrary.org/obo/DOID_1284 prolapse of female genital organ A prolapse of the female genital organ that is characterized by the descent of the bladder causing a bulge in the anterolateral vaginal walls. http://purl.obolibrary.org/obo/DOID_14133 Masters-Allen syndrome http://purl.obolibrary.org/obo/DOID_229 female reproductive system disease A female reproductive system disease that is characterized by an excessively mobile uterus secondary to lacerations of the broad and cardinal ligaments, specific tenderness with movement of the cervix and previous untoward obstetrics events, such as premature maternal voluntary efforts, precipate delivery, and forceps delivery. http://purl.obolibrary.org/obo/DOID_1414 ovarian dysfunction http://purl.obolibrary.org/obo/DOID_1100 ovarian disease An ovarian disease that is characterized by irregular or absent ovulation. http://purl.obolibrary.org/obo/DOID_14146 ureterolithiasis http://purl.obolibrary.org/obo/DOID_1426 ureteral disease An ureteral disease this is characterized by the formation of stoney concentrations in the ureter. http://purl.obolibrary.org/obo/DOID_14179 X-linked agammaglobulinemia http://purl.obolibrary.org/obo/DOID_2583 agammaglobulinemia An agammaglobulinemia that is that has_material_basis_in a mutation in the Bruton's tyrosine kinase (BTK) gene on the X chromosome resulting in X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. http://purl.obolibrary.org/obo/DOID_14188 frozen shoulder http://purl.obolibrary.org/obo/DOID_65 connective tissue disease A connective tissue disease characterized by restriction of both active and passive range of motion located_in the scapulohumeral joint and has_symptom pain and has_symptom restricted range of motion. http://purl.obolibrary.org/obo/DOID_14213 hypophosphatasia http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by disruption of mineralization of bones and teeth that has_material_basis_in mutation in ALPL on chromosome 1p36.12. http://purl.obolibrary.org/obo/DOID_14218 dihydropyrimidine dehydrogenase deficiency http://purl.obolibrary.org/obo/DOID_653 purine-pyrimidine metabolic disorder A purine-pyrimidine metabolic disorder that is an autosomal recessive metabolic disorder in which there is absent or significantly decreased activity of dihydropyrimidine dehydrogenase, an enzyme involved in the metabolism of uracil and thymine. http://purl.obolibrary.org/obo/DOID_14219 renal tubular acidosis http://purl.obolibrary.org/obo/DOID_447 renal tubular transport disease A renal tubular transport disease characterized by excess levels of acid in the blood, due to a failure of the kidneys to appropriately acidify the urine. http://purl.obolibrary.org/obo/DOID_14221 abdominal obesity-metabolic syndrome 1 http://purl.obolibrary.org/obo/DOID_0060611 abdominal obesity-metabolic syndrome An abdominal obesity-metabolic syndrome characterized by insulin resistance and hyperinsulinemia, dyslipidemia, essential hypertension, abdominal obesity, glucose intolerance or noninsulin-dependent diabetes mellitus and an increased risk of cardiovascular events. http://purl.obolibrary.org/obo/DOID_14223 ochronosis http://purl.obolibrary.org/obo/DOID_65 connective tissue disease A connective tissue disease characterized by bluish-brown discoloration of connective tissues that develops from the deposition of homogentisic acid and subsequent oxidation and polymerization reactions. http://purl.obolibrary.org/obo/DOID_14225 acute frontal sinusitis http://purl.obolibrary.org/obo/DOID_10791 frontal sinusitis A frontal sinusitis which lasts for less than 4 weeks. http://purl.obolibrary.org/obo/DOID_14227 azoospermia http://purl.obolibrary.org/obo/DOID_12336 male infertility A male infertility disease characterized by the absence of any measurable level of sperm in semen. http://purl.obolibrary.org/obo/DOID_14228 oligospermia http://purl.obolibrary.org/obo/DOID_12336 male infertility A male fertility issue defined as a low sperm concentration in the ejaculate. http://purl.obolibrary.org/obo/DOID_14230 scleromalacia perforans http://purl.obolibrary.org/obo/DOID_11343 scleral disease A scleral disease that is characterized by a painless severe necrotizing scleritis where the sclera is white, avascular, and thin. The choroid can become exposed leading to infarction and necrosis of related areas; the sclera can also thin such that the dark uvea protrudes through the front of the eye, forming a staphyloma which has_symptom loss of vision and appearance of a dark bulge. Scleromalacia perforans is usually caused by a rare complication of autoimmune disease like rheumatoid arthritis. http://purl.obolibrary.org/obo/DOID_14247 chronic purulent otitis media http://purl.obolibrary.org/obo/DOID_11506 suppurative otitis media A suppurative otitis media which is persistent and long-lasting. http://purl.obolibrary.org/obo/DOID_14250 Down syndrome http://purl.obolibrary.org/obo/DOID_0060429 chromosomal duplication syndrome A chromosomal disease that is characterized by flat-looking facial features and weak muscle tone (hypotonia) in infancy and is caused by trisomy of all or a critical portion of chromosome 21 and is associated with intellectual disability. http://purl.obolibrary.org/obo/DOID_14256 adult-onset Still's disease http://purl.obolibrary.org/obo/DOID_7148 rheumatoid arthritis A rheumatoid arthritis that is characterized by high fevers, rash, sore throat and joint pain. http://purl.obolibrary.org/obo/DOID_1426 ureteral disease http://purl.obolibrary.org/obo/DOID_18 urinary system disease A urinary system disease that is located_in the ureter. http://purl.obolibrary.org/obo/DOID_14261 fragile X syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by moderate to severe mental retardation, macroorchidism, and distinct facial features, including long face, large ears, and prominent jaw, and has_material_basis_in X-linked inheritance and a loss of FMR1 function. http://purl.obolibrary.org/obo/DOID_14264 benign neonatal seizures http://purl.obolibrary.org/obo/DOID_0050702 neonatal period electroclinical syndrome A neonatal period electroclinical syndrome that is characterized by tonic-clonic seizures in newborns occurring within the first seven days of life and ceasing within the first 15 weeks of life and has_material_basis_in autosomal dominant inheritance of voltage-gated potassium channels or a chromosomal inversion. http://purl.obolibrary.org/obo/DOID_14265 pulmonary valve insufficiency http://purl.obolibrary.org/obo/DOID_5749 pulmonary valve disease A pulmonary valve disease that occurs when the pulmonary valve is not strong enough to prevent backflow into the right ventricle. If it is secondary to pulmonary hypertension it is referred to as a Graham Steell murmur. http://purl.obolibrary.org/obo/DOID_14289 Ebstein anomaly http://purl.obolibrary.org/obo/DOID_0050826 tricuspid valve disease A tricuspid valve disease that is a congenital heart defect in which the septal leaflet of the tricuspid valve is displaced towards the apex of the right ventricle of the heart. http://purl.obolibrary.org/obo/DOID_14291 Noonan syndrome with multiple lentigines http://purl.obolibrary.org/obo/DOID_0080690 RASopathy A RASopathy that is characterized by autosomal dominant inheritance of brown skin spots called lentigines that are similar to freckles, heart defects, widely spaced eyes a sunken chest or protruding chest and short stature. http://purl.obolibrary.org/obo/DOID_14305 tuberculous empyema http://purl.obolibrary.org/obo/DOID_3798 pleural empyema A pleural empyema which involves presence of pus in the pleural cavity and calcified visceral pleura. It results from a large number of mycobacteria spilling into the pleural space, usually from rupture of a cavity or an adjacent paranchymal focus via a bronchopleural fistula. http://purl.obolibrary.org/obo/DOID_1432 blindness http://purl.obolibrary.org/obo/DOID_5614 eye disease An eye disease characterized by a lack or loss of vision. http://purl.obolibrary.org/obo/DOID_14320 generalized anxiety disorder http://purl.obolibrary.org/obo/DOID_2030 anxiety disorder An anxiety disorder that is characterized by long-lasting anxiety that is not focused on any one object or situation. http://purl.obolibrary.org/obo/DOID_14323 Marfan syndrome http://purl.obolibrary.org/obo/DOID_65 connective tissue disease A connective tissue disease that is characterized by tall stature, elongated extremities, mitral valve prolapse, aortic dilatation, aortic dissection, and subluxation of the lens. http://purl.obolibrary.org/obo/DOID_14325 mixed malaria http://purl.obolibrary.org/obo/DOID_12365 malaria A malaria that involves infection with more than one species of Plasmodium at the same time. http://purl.obolibrary.org/obo/DOID_14330 Parkinson's disease http://purl.obolibrary.org/obo/DOID_0050890 synucleinopathy A synucleinopathy that has_material_basis_in degeneration of the central nervous system that often impairs motor skills, speech, and other functions. http://purl.obolibrary.org/obo/DOID_14365 systemic primary carnitine deficiency disease http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder An amino acid metabolic disorder that involves defective proteins called carnitine transporters, which bring carnitine into cells and prevent its escape from the body preventing the body cannot utilize fats for energy. http://purl.obolibrary.org/obo/DOID_14374 norwegian scabies http://purl.obolibrary.org/obo/DOID_8295 scabies A scabies that involves infestation of human itch mite Sarcoptes scabiei type hominis in immunocompromised and elderly persons, which is characterized by vesicles and formation of thick crusts over the skin, accompanied by abundant mites but only slight itching. http://purl.obolibrary.org/obo/DOID_1440 Machado-Joseph disease http://purl.obolibrary.org/obo/DOID_1441 autosomal dominant cerebellar ataxia An autosomal dominant cerebellar ataxia that is characterized by slow degeneration of the hindbrain and has_material_basis_in expansion of CAG triplet repeats (glutamine) in the ATXN3 gene. http://purl.obolibrary.org/obo/DOID_1441 autosomal dominant cerebellar ataxia http://purl.obolibrary.org/obo/DOID_0050753 cerebellar ataxia A cerebellar ataxia that has_material_basis_in autosomal dominant inheritance. http://purl.obolibrary.org/obo/DOID_14415 Legg-Calve-Perthes disease http://purl.obolibrary.org/obo/DOID_8125 osteochondrosis An osteochondrosis that results_in death and fracture located_in hip joint. http://purl.obolibrary.org/obo/DOID_14418 dracunculiasis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that involves parasitic infection by the larvae of the nematode Dracunculus medinensis, which are transmitted to humans by drinking water containing copepods infected with the larvae. The female, which contains larvae, burrows into the deeper connective tissues or adjacent to long bones or joints of the extremities. The worm emerges as a whitish filament in the center of a painful ulcer, accompanied by inflammation and frequently by secondary bacterial infection. http://purl.obolibrary.org/obo/DOID_1443 cerebral degeneration http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is characterized by loss of structure or function of neurons, including death of neurons and loss of brain tissue. http://purl.obolibrary.org/obo/DOID_14443 cholinergic urticaria http://purl.obolibrary.org/obo/DOID_0060220 physical urticaria A physical urticaria induced by sweating. http://purl.obolibrary.org/obo/DOID_14444 sclerosing keratitis http://purl.obolibrary.org/obo/DOID_9858 deep keratitis A deep keratitis that is characterized by inflammation of the anterior sclera and subsequent inflammation of the adjacent cornea with opacification of the corneal stroma and has_symptom pain, red eyes, photophobia, tearing, and blurry vision. Sclerosing keratitis is caused by severe anterior scleritis that causes inflammation and injury to the adjacent corneal layer. Anterior scleritis can be caused by autoimmune diseases, connective tissue diseases, and infection. http://purl.obolibrary.org/obo/DOID_14447 gonadal dysgenesis http://purl.obolibrary.org/obo/DOID_1923 disorder of sexual development A disorder of sexual development that is characterized by a progressive loss of germ cells on the developing gonads of an embryo. http://purl.obolibrary.org/obo/DOID_14449 mixed gonadal dysgenesis http://purl.obolibrary.org/obo/DOID_14447 gonadal dysgenesis A gonadal dysgenesis that is characterized by progressive loss of primordial cells on the developing glands of an embryo, leading to extremely hypoplastic and dysfuctioning gonads resulting in one differentiated gonad and either a streak gonad or streak testis. http://purl.obolibrary.org/obo/DOID_14453 farmer's lung http://purl.obolibrary.org/obo/DOID_841 extrinsic allergic alveolitis An extrinsic allergic alveolitis which is induced by the inhalation of spores (Aspergillus sp and thermophilic actinomycetes) in dust from moldy hay or straw. It is characterized by sudden onset, fever, cough, expectoration, and breathlessness. http://purl.obolibrary.org/obo/DOID_14464 neuroleptic malignant syndrome http://purl.obolibrary.org/obo/DOID_863 nervous system disease A nervous system disease that is characterized by hyperthermia, muscular rigidity, autonomic dysfunction and altered consciousness and is associated with administration of antipsychotic and other central dopaminergic blockers. http://purl.obolibrary.org/obo/DOID_14472 hantavirus pulmonary syndrome http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results in infection located in lung, has_material_basis_in Sin Nombre virus, transmitted by deer mouse (Myodes glareolus), has_material_basis_in Black Creek Canal virus, transmitted by cotton rat (Sigmodon hispidus), has_material_basis_in Bayou virus, transmitted by marsh rice rat (Oryzomys palustris), has_material_basis_in Laguna Negra virus, transmitted by small vesper mouse (Calomys laucha), or has_material_basis_in Andes virus, transmitted by rice rat (Oligoryzomys longicaudatus). The infection has _ymptom fever, has_symptom muscle pain, has_symptom headache, has_symptom cough, has_symptom vomiting, has_symptom chills which rapidly progress to bilateral interstitial pulmonary infiltrates occurrence, pulmonary edema and hypoxia often resulting in death from shock or cardiac complications. http://purl.obolibrary.org/obo/DOID_14482 pemphigoid gestationis http://purl.obolibrary.org/obo/DOID_2731 vesiculobullous skin disease A vesiculobullous skin disease that is characterized by erythematous papules, vesicles, and plaques around the trunk and extremities that develop during pregnancy, particularly during the second and third trimesters, has_symptom pruritis, and has_material_basis_in autoantibodies to the basement membrane, which triggers a complement cascade and attracts eosinophils to the subepidermis. http://purl.obolibrary.org/obo/DOID_14484 sporotrichosis http://purl.obolibrary.org/obo/DOID_0050292 primary systemic mycosis A primary systemic mycosis that results_in a systemic fungal infection, has_material_basis_in Sporothrix schenckii in animals and humans and results_in_formation_of red papule at the site of inoculation. http://purl.obolibrary.org/obo/DOID_14499 Fabry disease http://purl.obolibrary.org/obo/DOID_1927 sphingolipidosis A sphingolipidosis that is characterized by the buildup of globotriaosylceramide in the body's cells and has_material_basis_in X-linked inherited mutations in the GLA gene, encoding alpha-galactosidase A, on chromosome Xq22. http://purl.obolibrary.org/obo/DOID_14504 Niemann-Pick disease http://purl.obolibrary.org/obo/DOID_1927 sphingolipidosis A sphingoliidosis characterized by the accumulation of the lipid sphingomyelin in lysosomes in cells. http://purl.obolibrary.org/obo/DOID_14515 WAGR syndrome http://purl.obolibrary.org/obo/DOID_0060388 chromosomal deletion syndrome A chromosomal deletion syndrome that is a nephroblastoma that results_in a rare genetic syndrome in which affected children are predisposed to develop Wilms tumor, Aniridia (absence of the colored part of the eye, the iris), genitourinary anomalies, and mental retardation. The condition results from a deletion on chromosome 11 resulting in the loss of several genes. As such, it is one of the best studied examples of a condition caused by loss of neighbouring (contiguous) genes. http://purl.obolibrary.org/obo/DOID_14525 Reye syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by acute brain damage and liver function problems. It has been associated with aspirin consumption by children with viral illness, although it also occurs in the absence of aspirin use. http://purl.obolibrary.org/obo/DOID_14557 primary pulmonary hypertension http://purl.obolibrary.org/obo/DOID_12326 chronic pulmonary heart disease A chronic pulmonary heart disease characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein, or pulmonary capillaries, among others, has symptoms shortness of breath, dizziness, fainting, leg swelling. http://purl.obolibrary.org/obo/DOID_14566 disease of cellular proliferation http://purl.obolibrary.org/obo/DOID_4 disease A disease that is characterized by abnormally rapid cell division. http://purl.obolibrary.org/obo/DOID_1459 hypothyroidism http://purl.obolibrary.org/obo/DOID_50 thyroid gland disease A thyroid gland disease which involves an underproduction of thyroid hormone. http://purl.obolibrary.org/obo/DOID_14669 acrodysostosis http://purl.obolibrary.org/obo/DOID_1934 dysostosis A dysostosis that results_in shortening of interphalangeal joints located_in hand or located_in foot along with mental deficiency. http://purl.obolibrary.org/obo/DOID_14671 multiple intestinal atresia http://purl.obolibrary.org/obo/DOID_5295 intestinal disease An intestinal disease characterized by the presence of numerous atresic segments in the small and large intestines that has_material_basis_in homozygous or compound heterozygous mutation in TTC7A on chromosome 2p21. http://purl.obolibrary.org/obo/DOID_14679 VACTERL association http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by the presence of at least three of the following: vertebral defects, anal atresia, cardiac defects, tracheo-esophageal fistula, renal anomalies, and limb abnormalities. http://purl.obolibrary.org/obo/DOID_1468 labyrinthitis http://purl.obolibrary.org/obo/DOID_3930 otitis interna An otitis interna which involves inflammation of the labyrinths. http://purl.obolibrary.org/obo/DOID_14681 Silver-Russell syndrome http://purl.obolibrary.org/obo/DOID_0080015 physical disorder A physical disorder that is characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. http://purl.obolibrary.org/obo/DOID_14686 Axenfeld-Rieger syndrome http://purl.obolibrary.org/obo/DOID_5614 eye disease An eye disease characterized by abnormalities of the front part of the eye, the anterior segment. http://purl.obolibrary.org/obo/DOID_14687 diastrophic dysplasia http://purl.obolibrary.org/obo/DOID_2256 osteochondrodysplasia An osteochondrodysplasia that has_material_basis_in abnormal cartilage development due to mutations in the SLC26A2 gene which results_in short limb dwarfism. http://purl.obolibrary.org/obo/DOID_14694 Johanson-Blizzard syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that involves abnormal development of the pancreas, nose and scalp, with mental retardation, hearing loss and growth failure. It is inherited in an autosomal recessive manner. http://purl.obolibrary.org/obo/DOID_14695 galactokinase deficiency http://purl.obolibrary.org/obo/DOID_9870 galactosemia A galactosemia that involves an accumulation of galactose and galactitol secondary to the decreased conversion of galactose to galactose-1-phosphate by galactokinase. http://purl.obolibrary.org/obo/DOID_14699 thrombocytopenia-absent radius syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A chromosomal deletion syndrome that is characterized by absence of the radius bone and platelet deficiency and bilateral absence of the radii with the presence of both thumbs and generally transient thrombocytopenia (less than 50 platelets/nL) and that has_material_basis_in compound heterozygosity for a rare null mutation involving the RBM8A gene on chromosome 1q12 on 1 allele and 1 of 2 low-frequency noncoding single-nucleotide polymorphisms in RBM8A on the other. http://purl.obolibrary.org/obo/DOID_1470 major depressive disorder http://purl.obolibrary.org/obo/DOID_1596 mental depression An endogenous depression that is characterized by an all-encompassing low mood accompanied by low self-esteem, and by loss of interest or pleasure in normally enjoyable activities. http://purl.obolibrary.org/obo/DOID_14701 propionic acidemia http://purl.obolibrary.org/obo/DOID_0060159 organic acidemia An organic acidemia that involes a nonfunctional propionyl CoA carboxylase affecting conversion of aminio acids and fats into sugar for energy. http://purl.obolibrary.org/obo/DOID_14702 branchiootorenal syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by branchial arch anomalies (branchial fistulas, clefts, or cysts), hearing impairment, structural defects of the outer, middle, and inner ear, and renal abnormalities. http://purl.obolibrary.org/obo/DOID_14711 FG syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by retardation, hyperactivity, hypotonia, broad thumbs, big first toes and a characteristic facial appearance including macrocephaly and has an X-linked recessive inheritance pattern. http://purl.obolibrary.org/obo/DOID_14717 centronuclear myopathy http://purl.obolibrary.org/obo/DOID_423 myopathy A myopathy characterized by abnormally located nuclei in skeletal muscle cells. The nuclei are located in the center of the cell, instead of their normal location at the periphery. http://purl.obolibrary.org/obo/DOID_14723 beta-ketothiolase deficiency http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder An amino acid metabolic disorder characterized by inability to process isoleucine and ketones, has_symptom recurrent ketoacidotic attacks in infancy marked by vomitting, lethargy, dehydration, and seizures, and has_material_basis_in mutation in the ACAT1 gene of chromosome 11q22.3 responsible for producing the ACAT1 enzyme in mitochondria, which processes isoleucine and ketones. http://purl.obolibrary.org/obo/DOID_14725 autosomal dominant microcephaly http://purl.obolibrary.org/obo/DOID_10907 microcephaly A microcephaly that has_material_basis_in heterozygous mutation in an autosomal gene. http://purl.obolibrary.org/obo/DOID_14731 Weaver syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by prenatal and postnatal overgrowth, accelerated osseous maturation, characteristic craniofacial appearance, and developmental delay and has_material_basis_in heterozygous mutation in the EZH2 gene on chromosome 7q36. http://purl.obolibrary.org/obo/DOID_14737 craniofrontonasal syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that has_material_basis_in mutation in the EFNB1 gene on chromosome Xq13 and is characterized in hemizygous males by hypertelorism and with greater severity in females by frontonasal dysplasia, craniofacial asymmetry, craniosynostosis, bifid nasal tip, grooved nails, wiry hair, and abnormalities of the thoracic skeleton. http://purl.obolibrary.org/obo/DOID_1474 aggressive periodontitis http://purl.obolibrary.org/obo/DOID_824 periodontitis A periodontitis that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as dental plaque and dental calculus resulting in inflammation and a loss of periodontium. http://purl.obolibrary.org/obo/DOID_14743 trichorhinophalangeal syndrome type I http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by short stature, sparse hair, a bulbous nasal tip and cone-shaped epiphyses (the growing ends of bones), as well as severe generalized shortening of all finger and toe bones (brachydactyly). http://purl.obolibrary.org/obo/DOID_14744 Partington syndrome http://purl.obolibrary.org/obo/DOID_0080012 X-linked recessive disease A syndrome characterized by intellectual disability, focal dystonia of the hands and dysarthria. http://purl.obolibrary.org/obo/DOID_14748 Sotos syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that occurs rarely and is characterized by excessive physical growth during the first 2 to 3 years of life. http://purl.obolibrary.org/obo/DOID_14749 methylmalonic acidemia http://purl.obolibrary.org/obo/DOID_0060159 organic acidemia An organic acidemia that involves an accumulation of methylmalonic acid in the blood. http://purl.obolibrary.org/obo/DOID_1475 lymphangioma http://purl.obolibrary.org/obo/DOID_60006 benign vascular tumor A benign vascular tumor that is composed of dilated lymphatic channels. http://purl.obolibrary.org/obo/DOID_14753 isovaleric acidemia http://purl.obolibrary.org/obo/DOID_0060159 organic acidemia An organic acidemia that disrupts or prevents normal metabolism of the branched-chain amino acid leucine. http://purl.obolibrary.org/obo/DOID_14755 argininosuccinic aciduria http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder An amino acid metabolic disorder that involves the accumulation of argininosuccinic acid (ASA) in the blood and urine. http://purl.obolibrary.org/obo/DOID_14762 calcaneonavicular coalition http://purl.obolibrary.org/obo/DOID_11971 synostosis A synostosis characterized by the fusion of carpal and tarsal bones, which causes stiffness and immobility of the hands and the feet. http://purl.obolibrary.org/obo/DOID_14764 Larsen syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome Asyndrome that is characterized by autosomal dominant inheritance of large-joint dislocations and characteristic craniofacial abnormalities. http://purl.obolibrary.org/obo/DOID_14766 renal agenesis http://purl.obolibrary.org/obo/DOID_557 kidney disease A renal disease that is characterized by the failure of one or both kidneys to develop. http://purl.obolibrary.org/obo/DOID_14773 cartilage-hair hypoplasia http://purl.obolibrary.org/obo/DOID_0050737 autosomal recessive disease An ectodermal dysplasia characterized by short-limbed short stature and fine, sparse hair that has_material_basis_in homozygous or compound heterozygous mutation in RMRP on chromosome 9p13.3. http://purl.obolibrary.org/obo/DOID_14778 blepharophimosis, ptosis, and epicanthus inversus syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by blepharophimosis, ptosis, epicanthus inversus, and telecanthus with (type I) or without (premature ovarian failure) that has_material_basis_in heterozygous or rarely homozygous mutation in FOXL2 on chromosome 3q22.3. http://purl.obolibrary.org/obo/DOID_14780 KBG syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by short stature, moderate to severe degrees of mental retardation, developmental abnormalities of the limbs, bones of the spine (vertebrae), extremities, and/or underdevelopment of the bones of the skeleton. http://purl.obolibrary.org/obo/DOID_14791 Leber congenital amaurosis http://purl.obolibrary.org/obo/DOID_5679 retinal disease A retinal disease that is characterized by nystagmus, sluggish or no pupillary responses, and severe vision loss or blindness. http://purl.obolibrary.org/obo/DOID_14793 hypohidrotic ectodermal dysplasia http://purl.obolibrary.org/obo/DOID_2121 ectodermal dysplasia An ectodermal dysplasia that is characterized by malformation of ectodermal (skin, hair, teeth and sweat glands) structures including hypotrichosis (sparseness of scalp and body hair), hypohidrosis (reduced ability to sweat), and hypodontia (congenital absence of teeth). http://purl.obolibrary.org/obo/DOID_14796 Dubowitz syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by microcephaly, growth retardation and a characteristic facial appearance including but not limited to narrow or triangular shaped head, micrognathia, ptosis, a broad, wide-tipped nose, and wide-set eyes with drooping eyelids. http://purl.obolibrary.org/obo/DOID_1483 gingival disease http://purl.obolibrary.org/obo/DOID_3388 periodontal disease A periodontal disease that is located_in the gums. http://purl.obolibrary.org/obo/DOID_1485 cystic fibrosis http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by the buildup of thick, sticky mucus that can damage many organs. http://purl.obolibrary.org/obo/DOID_1496 echinococcosis http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease A parasitic helminthiasis infectious disease that involves parasitic infection of humans and domestic animals caused by the larval stages of tapeworms of the genus Echinococcus in the liver, lungs, spleen, brain, heart and kidneys. http://purl.obolibrary.org/obo/DOID_1498 cholera http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that is described as an acute, diarrheal illness caused by infection of the intestine with the bacterium Vibrio cholerae, which is characterized by profuse watery diarrhea, vomiting, leg cramps, circulatory collapse and shock. http://purl.obolibrary.org/obo/DOID_15 reproductive system disease http://purl.obolibrary.org/obo/DOID_7 disease of anatomical entity A disease of anatomical entity that is located_in reproductive system organs. http://purl.obolibrary.org/obo/DOID_150 disease of mental health http://purl.obolibrary.org/obo/DOID_4 disease A disease that involves a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which are not a part of normal development or culture. http://purl.obolibrary.org/obo/DOID_1508 candidiasis http://purl.obolibrary.org/obo/DOID_2473 opportunistic mycosis An opportunistic mycosis that involves fungal infection of the mouth, throat, skin, scalp, vagina, fingers, nails, bronchi, lungs, heart and brain by Candida species, of which Candida albicans is the most common. Systemic Candida infections are usually confined to severely immunocompromised persons. http://purl.obolibrary.org/obo/DOID_1509 avoidant personality disorder http://purl.obolibrary.org/obo/DOID_1510 personality disorder A personality disorder that is characterized by a pervasive pattern of social inhibition, feelings of inadequacy, extreme sensitivity to negative evaluation, and avoidance of social interaction. http://purl.obolibrary.org/obo/DOID_1510 personality disorder http://purl.obolibrary.org/obo/DOID_150 disease of mental health A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work. http://purl.obolibrary.org/obo/DOID_1518 cecal disease http://purl.obolibrary.org/obo/DOID_5295 intestinal disease An intestinal disease located_in the cecum. http://purl.obolibrary.org/obo/DOID_1519 cecum carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A cecum cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. http://purl.obolibrary.org/obo/DOID_1521 cecum cancer http://purl.obolibrary.org/obo/DOID_5672 large intestine cancer A large intestine cancer that is located_in the cecum. http://purl.obolibrary.org/obo/DOID_1526 panniculitis http://purl.obolibrary.org/obo/DOID_37 skin disease A skin disease that is characterized by inflammation of subcutaneous adipose tissue. http://purl.obolibrary.org/obo/DOID_1532 pleural disease http://purl.obolibrary.org/obo/DOID_0050161 lower respiratory tract disease A thoracic disease which may involve inflammation of pleura, collection of air within the pleural cavity, abnormal collection of pleural fluid, abnormal growths on the pleura (pleural tumor) and pleural plaques. The main causes of pleural diseases including pleural effusions are congestive heart failure, malignancy, parapneumonic infections and pulmonary embolism. http://purl.obolibrary.org/obo/DOID_154 mixed cell type cancer http://purl.obolibrary.org/obo/DOID_0050687 cell type cancer A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from two germinal layers of tissue. http://purl.obolibrary.org/obo/DOID_1540 parathyroid carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma An endocrine gland cancer located_in the parathyroid glands located in the neck. http://purl.obolibrary.org/obo/DOID_1555 urticaria http://purl.obolibrary.org/obo/DOID_37 skin disease A skin disease characterized by skin rash notable for pale red, raised and itchy bumps, located_in the upper dermis. http://purl.obolibrary.org/obo/DOID_1557 hypersensitivity reaction type III disease http://purl.obolibrary.org/obo/DOID_0060056 hypersensitivity reaction disease A hypersensitivity reaction disease that is characterized by the accumulation of antigen-antibody immune complexes, causing an inflammatory response and injury. http://purl.obolibrary.org/obo/DOID_1558 angioedema http://purl.obolibrary.org/obo/DOID_37 skin disease A skin disease characterized by the rapid swelling of the dermis, subcutaneous tissue, mucosa and submucosal tissues. http://purl.obolibrary.org/obo/DOID_1561 cognitive disorder http://purl.obolibrary.org/obo/DOID_150 disease of mental health A disease of mental health that affects cognitive functions including memory processing, perception and problem solving. http://purl.obolibrary.org/obo/DOID_1562 chromoblastomycosis http://purl.obolibrary.org/obo/DOID_0050135 subcutaneous mycosis A subcutaneous mycosis that is a chronic subcutaneous fungal infection, which presents as nodular or verrucoid, ulcerated, or crusted skin lesions on exposed areas of skin caused by Fonsecaea pedrosoi, Fonsecaea compacta, Cladophialophora carrionii or Phialophora verrucosa. Histological examination reveals muriform cells (with perpendicular septations) or thick walled, dark-colored, rounded forms (copper pennies) that are characteristic of this infection. http://purl.obolibrary.org/obo/DOID_1563 dermatomycosis http://purl.obolibrary.org/obo/DOID_37 skin disease A cutaneous mycosis that results in fungal infection located in skin or of its appendages, has_material_basis_in Ascomycota fungi other than the dermatophytes. http://purl.obolibrary.org/obo/DOID_1564 fungal infectious disease http://purl.obolibrary.org/obo/DOID_0050117 disease by infectious agent A disease by infectious agent that results_in infection, has_material_basis_in Fungi, which pass the resistance barriers of the human or animal body. http://purl.obolibrary.org/obo/DOID_1575 rheumatic disease http://purl.obolibrary.org/obo/DOID_65 connective tissue disease A musculoskeletal system disease that involves inflammation or pain in the muscles, joints, or fibrous tissue. http://purl.obolibrary.org/obo/DOID_1579 respiratory system disease http://purl.obolibrary.org/obo/DOID_7 disease of anatomical entity A disease of anatomical entity that located_in the respiratory system which extends from the nasal sinuses to the diaphragm. http://purl.obolibrary.org/obo/DOID_1583 laryngeal tuberculosis http://purl.obolibrary.org/obo/DOID_3437 laryngitis A pulmonary tuberculosis causing granulomatous leisons in the larynx resulting from an inflammation caused by mycobacteria leading to hoarseness, dysphagia and odynophagia. http://purl.obolibrary.org/obo/DOID_1584 acute chest syndrome http://purl.obolibrary.org/obo/DOID_850 lung disease A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion. The disease has_symptom fever, has_symptom pleuritic chest pain, has_symptom tachypnea, has_symptom cough, has_symptom hypoxemia, has_symptom marked leukocytosis, and has_symptom diffuse infiltrates on chest radiograph. http://purl.obolibrary.org/obo/DOID_1586 rheumatic fever http://purl.obolibrary.org/obo/DOID_104 bacterial infectious disease A connective tissue disease that develops from an antecedent Group A Streptococcal pharyngeal infection and has_symptom carditis, has_symptom polyarthritis, has_symptom chorea, has_symptom erythema marginatum, has_symptom subcutaneous nodules, has_symptom arthralgia, has_symptom prolonged PR interval, and/or has_symptom fever. http://purl.obolibrary.org/obo/DOID_1588 thrombocytopenia http://purl.obolibrary.org/obo/DOID_2218 blood platelet disease A blood platelet disease that is characterized by low a platelet count in the blood. http://purl.obolibrary.org/obo/DOID_1595 endogenous depression http://purl.obolibrary.org/obo/DOID_1470 major depressive disorder A mental depression that is characterized by a dysregulation of the endogenous opioid system and not of the monaminergic system. http://purl.obolibrary.org/obo/DOID_16 integumentary system disease http://purl.obolibrary.org/obo/DOID_7 disease of anatomical entity A disease of anatomical entity that is located_in the integumentary system comprising the skin and its appendages. http://purl.obolibrary.org/obo/DOID_1607 hypoglycemic coma http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is characterized by coma or unconsciousness, develops from a prolonged insufficient supply of glucose to the brain, has_symptom decreased cognition, has_symptom aberrant behavior, has_symptom seizure, and has_symptom coma. http://purl.obolibrary.org/obo/DOID_161 keratosis http://purl.obolibrary.org/obo/DOID_37 skin disease A skin disease characterized_by growth of keratin on the skin or mucous membranes. http://purl.obolibrary.org/obo/DOID_1612 breast cancer http://purl.obolibrary.org/obo/DOID_5093 thoracic cancer A thoracic cancer that originates in the mammary gland. http://purl.obolibrary.org/obo/DOID_1618 breast fibroadenoma http://purl.obolibrary.org/obo/DOID_657 adenoma A breast benign neoplasm comprised of fibrous and glandoular tissues located_in breast. http://purl.obolibrary.org/obo/DOID_162 cancer http://purl.obolibrary.org/obo/DOID_14566 disease of cellular proliferation A disease of cellular proliferation that is malignant and primary, characterized by uncontrolled cellular proliferation, local cell invasion and metastasis. http://purl.obolibrary.org/obo/DOID_1625 breast adenoma http://purl.obolibrary.org/obo/DOID_657 adenoma A breast benign neoplasm that is has_material_basis_in epithelial tissue in which tumor cells form glands or glandlike structures. http://purl.obolibrary.org/obo/DOID_1642 breast adenomyoepithelioma http://purl.obolibrary.org/obo/DOID_3004 breast myoepithelial neoplasm A breast myoepithelial neoplasm that affects the breast and is characterized by biphasic proliferation of both epithelial and myoepithelial cells. http://purl.obolibrary.org/obo/DOID_1657 ventricular septal defect http://purl.obolibrary.org/obo/DOID_1681 heart septal defect A heart septal defect characterized by an opening in the interventricular septum, causing a shunt between ventricles. http://purl.obolibrary.org/obo/DOID_1659 supratentorial cancer http://purl.obolibrary.org/obo/DOID_1319 brain cancer A brain cancer that is located in the supratentorial region. http://purl.obolibrary.org/obo/DOID_1664 pineoblastoma http://purl.obolibrary.org/obo/DOID_5032 pineal gland cancer A pineal gland neoplasm located_in the brain. http://purl.obolibrary.org/obo/DOID_1673 pneumothorax http://purl.obolibrary.org/obo/DOID_1532 pleural disease A pleural disease that is characterized as an abnormal collection of air in the pleural space between the lung and the chest wall. http://purl.obolibrary.org/obo/DOID_1679 cystitis http://purl.obolibrary.org/obo/DOID_365 bladder disease A bladder disease that is characterized by inflammation of the bladder. http://purl.obolibrary.org/obo/DOID_1686 glaucoma http://purl.obolibrary.org/obo/DOID_5614 eye disease An eye disease that is characterized by an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. http://purl.obolibrary.org/obo/DOID_1687 neovascular glaucoma http://purl.obolibrary.org/obo/DOID_1686 glaucoma A glaucoma characterized by narrowing of the anterior chamber angle secondary to neovascularization along the iris and iridocorneal angle such that the aqueous fluid outflow is blocked and intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Neovascular glaucoma has_symptom progressive peripheral vision loss, decreased vision, and pain, redness, and headache in acute cases. Neovascular glaucoma can be related to abnormal angiogenesis with ischemic retinal diseases, inflammation, diabetes mellitus, intraocular malignancy, and autoinmmune diseases. http://purl.obolibrary.org/obo/DOID_169 neuroendocrine tumor http://purl.obolibrary.org/obo/DOID_170 endocrine gland cancer An endocrine gland cancer that has_material_basis_in neuroendocrine cells. http://purl.obolibrary.org/obo/DOID_1697 ichthyosis http://purl.obolibrary.org/obo/DOID_37 skin disease A skin disease characterized by drying and scaling of skin with the accumulation of thick scales and cracks that may be painful or bleed. http://purl.obolibrary.org/obo/DOID_17 musculoskeletal system disease http://purl.obolibrary.org/obo/DOID_7 disease of anatomical entity A disease of anatomical entity that occurs in the muscular and/or skeletal system. http://purl.obolibrary.org/obo/DOID_170 endocrine gland cancer http://purl.obolibrary.org/obo/DOID_0050686 organ system cancer An organ system cancer located_in endocrine system that is characterized by uncontrolled cellular proliferation of the hormone producing glands of the endocrine system. http://purl.obolibrary.org/obo/DOID_1700 X-linked ichthyosis http://purl.obolibrary.org/obo/DOID_1697 ichthyosis An ichthyosis that is characterized by a build-up of scales on the skin, typically on the back of the neck and trunk resulting from skin cells that do not properly separate from the outermost surface of the skin, and has_material_basis_in X-linked recessive mutation or deletion of the STS gene on chromosome Xp22. http://purl.obolibrary.org/obo/DOID_1701 steroid inherited metabolic disorder http://purl.obolibrary.org/obo/DOID_3146 lipid metabolism disorder A lipid metabolism disorder that involves defects in steroid metabolism. http://purl.obolibrary.org/obo/DOID_1702 ichthyosis vulgaris http://purl.obolibrary.org/obo/DOID_1697 ichthyosis An ichthyosis that has_material_basis_in heterozygous mutation in the filaggrin gene on chromosome 1q21 and is characterized by dead skin cells accumulate in thick, dry scales on your skin's surface. http://purl.obolibrary.org/obo/DOID_1712 aortic valve stenosis http://purl.obolibrary.org/obo/DOID_62 aortic valve disease An aortic valve disease that is characterized by narrowing of the heart's aortic valve opening. http://purl.obolibrary.org/obo/DOID_1725 peritoneum cancer http://purl.obolibrary.org/obo/DOID_0050686 organ system cancer An organ system cancer that is located in the peritoneum. http://purl.obolibrary.org/obo/DOID_1731 histoplasmosis http://purl.obolibrary.org/obo/DOID_0050292 primary systemic mycosis A primary systemic mycosis that results in systemic fungal infection, has_material_basis_in Histoplasma capsulatum var capsulatum or has_material_basis_in Histoplasma capsulatum var duboisii, transmitted_by airborne spores and has_symptom nonproductive cough, has_symptom headache, has_symptom loss of appetite and has_symptom muscle pains. http://purl.obolibrary.org/obo/DOID_1733 cryptosporidiosis http://purl.obolibrary.org/obo/DOID_5295 intestinal disease A coccidiosis that involves a parasitic protozoan infection of the intestine of humans and a wide range of animals caused by Cryptosporidium species, through contaminated water and food, The symptoms include watery diarrhea, dehydration, weight loss, abdominal pain, fever, nausea and vomiting. Cryptosporidium infections have also been found in other digestive tract organs, the lungs, and conjunctiva. Immunocompromised persons are at greater risk of developing the infection. http://purl.obolibrary.org/obo/DOID_1749 squamous cell carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A carcinoma that derives_from squamous epithelial cells. http://purl.obolibrary.org/obo/DOID_175 vascular cancer http://purl.obolibrary.org/obo/DOID_178 vascular disease A cardiovascular cancer that is located_in blood vessels. http://purl.obolibrary.org/obo/DOID_176 cardiovascular cancer http://purl.obolibrary.org/obo/DOID_1287 cardiovascular system disease An organ system cancer that located_in the heart and blood vessels. http://purl.obolibrary.org/obo/DOID_178 vascular disease http://purl.obolibrary.org/obo/DOID_1287 cardiovascular system disease A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart. http://purl.obolibrary.org/obo/DOID_1781 thyroid gland cancer http://purl.obolibrary.org/obo/DOID_50 thyroid gland disease An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage. http://purl.obolibrary.org/obo/DOID_1787 pericarditis http://purl.obolibrary.org/obo/DOID_0050829 pericardium disease A pericardium disease that is characterized by an inflammation of the pericardium and has_symptom chest pain. http://purl.obolibrary.org/obo/DOID_18 urinary system disease http://purl.obolibrary.org/obo/DOID_7 disease of anatomical entity A disease of anatomical entity that is located_in kidney, ureter, bladder and urethra. http://purl.obolibrary.org/obo/DOID_182 calcinosis http://purl.obolibrary.org/obo/DOID_10575 calcium metabolism disease A calcium metabolism disease that is the result of the formation of calcium deposits in any soft tissue. http://purl.obolibrary.org/obo/DOID_1826 epilepsy http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions. http://purl.obolibrary.org/obo/DOID_1827 idiopathic generalized epilepsy http://purl.obolibrary.org/obo/DOID_1826 epilepsy An epilepsy syndrome that is characterised by generalised seizures with no apparent cause which arise from many independent foci (multifocal epilepsies) or from epileptic circuits that involve the whole brain. http://purl.obolibrary.org/obo/DOID_184 bone cancer http://purl.obolibrary.org/obo/DOID_201 connective tissue cancer A connective tissue cancer that is located_in bone and is characterized by uncontrolled cellular proliferation that destroys normal bone tissue. http://purl.obolibrary.org/obo/DOID_1882 atrial heart septal defect http://purl.obolibrary.org/obo/DOID_1681 heart septal defect A heart septal defect located_in in the septum that separates the two atria of the heart. http://purl.obolibrary.org/obo/DOID_1884 viral hepatitis http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A hepatitis that involves viral infection causing inflammation of the liver. http://purl.obolibrary.org/obo/DOID_1891 optic nerve disease http://purl.obolibrary.org/obo/DOID_5656 cranial nerve disease A cranial nerve disease that is located_in the optic nerve. http://purl.obolibrary.org/obo/DOID_1909 melanoma http://purl.obolibrary.org/obo/DOID_0050687 cell type cancer A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from melanocytes which are found in skin, the bowel and the eye. http://purl.obolibrary.org/obo/DOID_192 sex cord-gonadal stromal tumor http://purl.obolibrary.org/obo/DOID_193 reproductive organ cancer A reproductive organ cancer that is located_in the sex cord-derived tissues of the ovary or testis and derives_from granulosa cells, Leydig cells, Sertoli cells, and fibroblasts. http://purl.obolibrary.org/obo/DOID_1923 disorder of sexual development http://purl.obolibrary.org/obo/DOID_2277 gonadal disease A gonadal disease that is characterized by atypical development of chromosomal, gonadal, or anatomic sex. http://purl.obolibrary.org/obo/DOID_1924 hypogonadism http://purl.obolibrary.org/obo/DOID_2277 gonadal disease A gonadal disease that is characterized by diminished functional activity of the gonads. http://purl.obolibrary.org/obo/DOID_1927 sphingolipidosis http://purl.obolibrary.org/obo/DOID_9455 lipid storage disease A lipid storage disease characterized by functional deficiencies in the enzymes needed for lysosomal degradation of sphingolipid substrates. http://purl.obolibrary.org/obo/DOID_193 reproductive organ cancer http://purl.obolibrary.org/obo/DOID_15 reproductive system disease An organ system cancer that is manifested in the reproductive organs. http://purl.obolibrary.org/obo/DOID_1934 dysostosis http://purl.obolibrary.org/obo/DOID_0080006 bone development disease A bone development disease that results in defective ossification of located in bone. http://purl.obolibrary.org/obo/DOID_1935 Bardet-Biedl syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that results from mutations in multiple BBS genes affecting cellular cilia structure or function (ciliopathy) resulting in variable presentation and characterized principally by obesity, retinitis pigmentosa,vision loss, polydactyly, mental retardation, hypogonadism, and renal failure in some cases. http://purl.obolibrary.org/obo/DOID_1962 fallopian tube disease http://purl.obolibrary.org/obo/DOID_229 female reproductive system disease A female reproductive system disease that is located_in the fallopian tube. http://purl.obolibrary.org/obo/DOID_1969 cerebral palsy http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is caused by damage to the motor control centers of the developing brain during pregnancy, during childbirth or after birth, which affects muscle movement and balance. http://purl.obolibrary.org/obo/DOID_201 connective tissue cancer http://purl.obolibrary.org/obo/DOID_65 connective tissue disease A musculoskeletal system cancer that is located_in connective tissue. http://purl.obolibrary.org/obo/DOID_2030 anxiety disorder http://purl.obolibrary.org/obo/DOID_1561 cognitive disorder A cognitive disorder that involves an excessive, irrational dread of everyday situations. http://purl.obolibrary.org/obo/DOID_2033 communication disorder http://purl.obolibrary.org/obo/DOID_0060038 specific developmental disorder A specific developmental disorder that involves specific developmental disorders of speech and language. http://purl.obolibrary.org/obo/DOID_2034 encephalomalacia http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is characterized by cerebral softening located_in cerebrum has_material_basis_in injured or dead cells of the central nervous system. http://purl.obolibrary.org/obo/DOID_204 enthesopathy http://purl.obolibrary.org/obo/DOID_65 connective tissue disease A connective tissue disease characterized by damage of tissues located_in the entheses, the site of insertion of tendons or ligaments into bones or joint capsules, with symptoms of pain, swelling and inflammation. http://purl.obolibrary.org/obo/DOID_205 hyperostosis http://purl.obolibrary.org/obo/DOID_0080005 bone remodeling disease A bone remodeling disease that results in an abnormal growth of located in bone. http://purl.obolibrary.org/obo/DOID_2051 maxillary sinusitis http://purl.obolibrary.org/obo/DOID_0050127 sinusitis A sinusitis which involves infection of maxillary sinuses that causes pain or pressure over the cheeks just below the eyes, tooth ache, and headache. http://purl.obolibrary.org/obo/DOID_2059 vulvar disease http://purl.obolibrary.org/obo/DOID_229 female reproductive system disease A female reproductive system disease that is located_in the vulva. http://purl.obolibrary.org/obo/DOID_2113 coccidiosis http://purl.obolibrary.org/obo/DOID_2789 parasitic protozoa infectious disease A parasitic protozoa infectious disease that occurs in the intestinal tract of animals and humans caused by Coccidia protozoa. Immunocompromised persons are at greater risk of developing the infection. http://purl.obolibrary.org/obo/DOID_2115 B cell deficiency http://purl.obolibrary.org/obo/DOID_612 primary immunodeficiency disease A primary immunnodeficiency disease that is caused by a lack of infection-fighting antibody producing B cells (immunoglobulins) or B cells that are not functioning properly. http://purl.obolibrary.org/obo/DOID_2123 tularemia http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that has_material_basis_in Francisella tularensis, which is transmitted by dog tick bite (Dermacentor variabilis), transmitted by deer flies (Chrysops sp) or transmitted by contact with infected animal tissues. http://purl.obolibrary.org/obo/DOID_2149 urogenital tuberculosis http://purl.obolibrary.org/obo/DOID_0050598 extrapulmonary tuberculosis An extrapulmonary tuberculosis that is located_in urogenital system. http://purl.obolibrary.org/obo/DOID_216 dental caries http://purl.obolibrary.org/obo/DOID_214 teeth hard tissue disease A teeth hard tissue disease that is characterized by damage to a tooth that can happen when decay-causing bacteria in your mouth make acids that attack the tooth’s surface, or enamel. http://purl.obolibrary.org/obo/DOID_2170 vaginitis http://purl.obolibrary.org/obo/DOID_121 vaginal disease A vaginal disease that is characterized by inflammation of the vagina. http://purl.obolibrary.org/obo/DOID_2187 amelogenesis imperfecta http://purl.obolibrary.org/obo/DOID_693 dental enamel hypoplasia A dental enamel hypoplasia characterized by abnormal enamel formation. http://purl.obolibrary.org/obo/DOID_219 colon cancer http://purl.obolibrary.org/obo/DOID_9256 colorectal cancer A colorectal cancer that is located_in the colon. http://purl.obolibrary.org/obo/DOID_2218 blood platelet disease http://purl.obolibrary.org/obo/DOID_1247 blood coagulation disease A blood coagulation disease that is characterized by an abnormal increase or decrease in platelets or platelet dysfunction. http://purl.obolibrary.org/obo/DOID_2234 focal epilepsy http://purl.obolibrary.org/obo/DOID_1826 epilepsy An epilepsy syndrome that is characterised by seizures that are preceded by an isolated disturbance of a cerebral function and arise from an epileptic focus, a small portion of the brain that serves as the irritant driving the epileptic response. http://purl.obolibrary.org/obo/DOID_224 transient cerebral ischemia http://purl.obolibrary.org/obo/DOID_2316 brain ischemia A brain ischemia that is characterized by ischemia of brief duration and without resultant tissue death. http://purl.obolibrary.org/obo/DOID_225 syndrome http://purl.obolibrary.org/obo/DOID_4 disease A disease characterized by a group of signs and symptoms that occur together and characterize a particular abnormality. http://purl.obolibrary.org/obo/DOID_2253 cervix disease http://purl.obolibrary.org/obo/DOID_345 uterine disease A uterine disease that is located_in the cervix. http://purl.obolibrary.org/obo/DOID_2256 osteochondrodysplasia http://purl.obolibrary.org/obo/DOID_0080006 bone development disease A bone development disease that results_in defective development of cartilage or bone. http://purl.obolibrary.org/obo/DOID_227 ankylosis http://purl.obolibrary.org/obo/DOID_381 arthropathy Ankylosis is a arthropathy where there is a stiffness of a joint, the result of injury or disease. The rigidity may be complete or partial and may be due to inflammation of the tendinous or muscular structures outside the joint or of the tissues of the joint itself. http://purl.obolibrary.org/obo/DOID_229 female reproductive system disease http://purl.obolibrary.org/obo/DOID_15 reproductive system disease A reproductive system disease that impairs the ability to reproduce and is located in the uterus, vagina, cervix, ovaries or fallopian tubes. http://purl.obolibrary.org/obo/DOID_231 motor neuron disease http://purl.obolibrary.org/obo/DOID_1289 neurodegenerative disease A neurodegenerative disease that is located_in the motor neurones. http://purl.obolibrary.org/obo/DOID_2340 craniosynostosis http://purl.obolibrary.org/obo/DOID_11971 synostosis A synostosis that results_in premature fusion located_in skull. http://purl.obolibrary.org/obo/DOID_2345 plasma protein metabolism disease http://purl.obolibrary.org/obo/DOID_655 inherited metabolic disorder An inherited metabolic disorder that involves plasma protein metabolism malfunction. http://purl.obolibrary.org/obo/DOID_2349 arteriosclerosis http://purl.obolibrary.org/obo/DOID_0050828 artery disease An artery disease that is characterized by a thickening and hardening of arterial walls in the arteries. http://purl.obolibrary.org/obo/DOID_235 colonic benign neoplasm http://purl.obolibrary.org/obo/DOID_5353 colonic disease An intestinal benign neoplasm that is located_in the colon. http://purl.obolibrary.org/obo/DOID_2355 anemia http://purl.obolibrary.org/obo/DOID_74 hematopoietic system disease A hematopoietic system disease that is characterized by a decrease in the normal number of red blood cells. http://purl.obolibrary.org/obo/DOID_2365 West Nile encephalitis http://purl.obolibrary.org/obo/DOID_936 brain disease A viral infectious disease that results in inflammation located in brain, has_material_basis_in West Nile virus, which is transmitted_by Culex, transmitted by Aedes, and transmitted_by Anopheles species of mosquitoes. The infection has_symptom high fever, has_symptom headache, has_symptom neck stiffness, has_symptom stupor, has_symptom disorientation, has_symptom coma, has_symptom tremors, has_symptom convulsions, has_symptom muscle weakness, has_symptom vision loss, has_symptom numbness, and has_symptom paralysis. http://purl.obolibrary.org/obo/DOID_2377 multiple sclerosis http://purl.obolibrary.org/obo/DOID_3213 demyelinating disease A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring. http://purl.obolibrary.org/obo/DOID_2383 neonatal jaundice http://purl.obolibrary.org/obo/DOID_10123 pigmentation disease A pigmentation disease characterized by a high level of bilirubin in the blood, causing a yellowing of the skin and other tissues of a newborn infant. http://purl.obolibrary.org/obo/DOID_2394 ovarian cancer http://purl.obolibrary.org/obo/DOID_120 female reproductive organ cancer A female reproductive organ cancer that is located_in the ovary. http://purl.obolibrary.org/obo/DOID_2452 thrombophilia http://purl.obolibrary.org/obo/DOID_1247 blood coagulation disease A blood coagulation disease that is characterized by an increased tendency to form clots. http://purl.obolibrary.org/obo/DOID_2468 psychotic disorder http://purl.obolibrary.org/obo/DOID_1561 cognitive disorder A cognitive disorder that involves abnormal thinking and perceptions resulting in a disconnection with reality. http://purl.obolibrary.org/obo/DOID_2473 opportunistic mycosis http://purl.obolibrary.org/obo/DOID_0050136 systemic mycosis A systemic mycosis that results_in fungal infection located_in human body of immunocompromised individuals, has_material_basis_in Fungi. The organisms invade via the respiratory tract, alimentary tract, or intravascular devices. http://purl.obolibrary.org/obo/DOID_2494 angiodysplasia http://purl.obolibrary.org/obo/DOID_178 vascular disease A vascular disease that is characterized as a small vascular malformation of the gut. http://purl.obolibrary.org/obo/DOID_2527 nephrosis http://purl.obolibrary.org/obo/DOID_576 proteinuria A proteinuria that is characterized by the leaking of blood protein into the urine, swelling or edema, and degenerative lesions without inflammation. http://purl.obolibrary.org/obo/DOID_2531 hematologic cancer http://purl.obolibrary.org/obo/DOID_74 hematopoietic system disease An organ system cancer located in the hematological system that is characterized by uncontrolled cellular proliferation in blood, bone marrow and lymph nodes. http://purl.obolibrary.org/obo/DOID_255 hemangioma http://purl.obolibrary.org/obo/DOID_178 vascular disease A cardiovascular organ benign neoplasm that has_material_basis_in endothelial cells that line blood vessels and is characterised by increased number of normal or abnormal vessels filled with blood. http://purl.obolibrary.org/obo/DOID_2557 chondromalacia http://purl.obolibrary.org/obo/DOID_6227 articular cartilage disease A cartilage disease that is characterized by softening and breakdown of cartilage inside a joint. http://purl.obolibrary.org/obo/DOID_2568 cervicitis http://purl.obolibrary.org/obo/DOID_2253 cervix disease A cervix disease that is characterized by inflammation of the cervix. http://purl.obolibrary.org/obo/DOID_2580 rhizomelic chondrodysplasia punctata http://purl.obolibrary.org/obo/DOID_2581 chondrodysplasia punctata A chondrodysplasia punctata that is characterized by disproportionately short stature primarily affecting the proximal parts of the extremities, a typical facial appearance including a broad nasal bridge, epicanthus, high-arched palate, dysplastic external ears, and micrognathia, congenital contractures, characteristic ocular involvement, dwarfism, and severe mental retardation with spasticity. http://purl.obolibrary.org/obo/DOID_2581 chondrodysplasia punctata http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by abnormal calcification of the epiphyses, causing stippling in radiography. http://purl.obolibrary.org/obo/DOID_2583 agammaglobulinemia http://purl.obolibrary.org/obo/DOID_2115 B cell deficiency A B cell deficiency that is caused by a reduction in all types of gamma globulins. http://purl.obolibrary.org/obo/DOID_2596 larynx cancer http://purl.obolibrary.org/obo/DOID_786 laryngeal disease A respiratory system cancer that is located_in the larynx. http://purl.obolibrary.org/obo/DOID_26 pancreas disease http://purl.obolibrary.org/obo/DOID_28 endocrine system disease An endocrine system disease that is located_in the pancreas. http://purl.obolibrary.org/obo/DOID_2602 chondroma http://purl.obolibrary.org/obo/DOID_0060084 cell type benign neoplasm A cell type benign neoplasm that is a cartilaginous tumor encapsulated with a lobular growing pattern. http://purl.obolibrary.org/obo/DOID_2615 papilloma http://purl.obolibrary.org/obo/DOID_0060084 cell type benign neoplasm A cell type benign neoplam that is composed of epithelial tissue on papillae of vascularized connective tissue. http://purl.obolibrary.org/obo/DOID_2658 dermoid cyst http://purl.obolibrary.org/obo/DOID_2660 cystic teratoma A cystic teratoma that is composed exclusively of mature tissues derived from two or three germ layers (ectoderm, mesoderm and endoderm). http://purl.obolibrary.org/obo/DOID_2703 synovitis http://purl.obolibrary.org/obo/DOID_65 connective tissue disease A connective tissue disease that results_in inflammation located_in synovial membrane that lines a synovial joint which causes pain and swelling. http://purl.obolibrary.org/obo/DOID_272 hepatic vascular disease http://purl.obolibrary.org/obo/DOID_409 liver disease A vascular disease that is located_in the liver. http://purl.obolibrary.org/obo/DOID_2722 acrodermatitis http://purl.obolibrary.org/obo/DOID_2723 dermatitis A dermatitis that selectively affects the hands and feet. http://purl.obolibrary.org/obo/DOID_2723 dermatitis http://purl.obolibrary.org/obo/DOID_37 skin disease A skin disease characterized by itchy, erythematous, vesicular, weeping and crusting patches of skin. http://purl.obolibrary.org/obo/DOID_2731 vesiculobullous skin disease http://purl.obolibrary.org/obo/DOID_37 skin disease A skin disease that is characterized by fluid filled blisters. http://purl.obolibrary.org/obo/DOID_2741 bilirubin metabolic disorder http://purl.obolibrary.org/obo/DOID_655 inherited metabolic disorder An inherited metabolic disorder that involves elevated levels of bilirubin resulting from disruption of bilirubin metabolism. http://purl.obolibrary.org/obo/DOID_2742 auditory system disease http://purl.obolibrary.org/obo/DOID_0050155 sensory system disease A sensory system disease that is characterized by auditory dysfunction located_in the auditory system. http://purl.obolibrary.org/obo/DOID_2747 glycogen storage disease http://purl.obolibrary.org/obo/DOID_0050728 glycogen metabolism disorder A glycogen metabolism disorder that has_material_basis_in enzymes deficiencies necessary in the processing of glycogen synthesis or breakdown within muscles, liver, and other cell types. http://purl.obolibrary.org/obo/DOID_2769 tic disorder http://purl.obolibrary.org/obo/DOID_0060038 specific developmental disorder A specific developmental disorder that is characterized by the persistent presence of involuntary brief movements or sounds occuring intermittently and unpredictably out of a background of normal motor activity. http://purl.obolibrary.org/obo/DOID_2786 cerebellar disease http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is characterized by damage to brain substance located_in cerebellum; has_symptom ataxia, has_symptom dysarthria, and has_symptom cerebellar cognitive affective syndrome. http://purl.obolibrary.org/obo/DOID_2789 parasitic protozoa infectious disease http://purl.obolibrary.org/obo/DOID_1398 parasitic infectious disease A parasitic infectious disease that is caused by parasitic protozoa which are microorganisms classified as unicellular eukaryotes. http://purl.obolibrary.org/obo/DOID_2797 idiopathic interstitial pneumonia http://purl.obolibrary.org/obo/DOID_552 pneumonia A pneumonia located_in the lung parenchyma of unknown cause. http://purl.obolibrary.org/obo/DOID_28 endocrine system disease http://purl.obolibrary.org/obo/DOID_7 disease of anatomical entity A disease of anatomical entity that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body. http://purl.obolibrary.org/obo/DOID_2841 asthma http://purl.obolibrary.org/obo/DOID_1176 bronchial disease A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. http://purl.obolibrary.org/obo/DOID_2843 long QT syndrome http://purl.obolibrary.org/obo/DOID_0060036 intrinsic cardiomyopathy An autosomal genetic disease that is characterized by delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsade de pointes (TDP, a form of irregular heartbeat that originates from the ventricles). http://purl.obolibrary.org/obo/DOID_285 hairy cell leukemia http://purl.obolibrary.org/obo/DOID_1040 chronic lymphocytic leukemia A chronic lymphocytic leukemia that is characterized by over production of B cells (lymphocytes) by the bone marrow where the B cells appear hairy under a microscope. http://purl.obolibrary.org/obo/DOID_2862 glucosephosphate dehydrogenase deficiency http://purl.obolibrary.org/obo/DOID_2978 carbohydrate metabolic disorder A carbohydrate metabolic disorder that is characterised by abnormally low levels of glucose-6-phosphate dehydrogenase (abbreviated G6PD or G6PDH). http://purl.obolibrary.org/obo/DOID_289 endometriosis http://purl.obolibrary.org/obo/DOID_229 female reproductive system disease A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body. http://purl.obolibrary.org/obo/DOID_2914 immune system disease http://purl.obolibrary.org/obo/DOID_7 disease of anatomical entity A disease of anatomical entity that is located_in the immune system. http://purl.obolibrary.org/obo/DOID_2916 hypersensitivity reaction type IV disease http://purl.obolibrary.org/obo/DOID_0060056 hypersensitivity reaction disease A hypersensitivity reaction disease that is characterized by a cell-mediated response to antigens, where Th1 helper T cells react with antigens on antigen-presenting cells and cause a delayed type immune response. http://purl.obolibrary.org/obo/DOID_2921 glomerulonephritis http://purl.obolibrary.org/obo/DOID_10952 nephritis A nephritis that causes inflammation of the glomeruli located_in kidney. http://purl.obolibrary.org/obo/DOID_2959 hyperimmunoglobulin syndrome http://purl.obolibrary.org/obo/DOID_2115 B cell deficiency A B cell deficiency that is characterized by relative predominance of certain immunoglobulin subtypes and deficiencies of others. http://purl.obolibrary.org/obo/DOID_2978 carbohydrate metabolic disorder http://purl.obolibrary.org/obo/DOID_655 inherited metabolic disorder An inherited metabolic disorder that affect the catabolism and anabolism of carbohydrates. http://purl.obolibrary.org/obo/DOID_299 adenocarcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A carcinoma that has_material_basis_in abnormally proliferating cells, derives_from epithelial cells, which originate in glandular tissue. http://purl.obolibrary.org/obo/DOID_2998 testicular cancer http://purl.obolibrary.org/obo/DOID_3856 male reproductive organ cancer A male reproductive system cancer that is located_in the testicles. http://purl.obolibrary.org/obo/DOID_3004 breast myoepithelial neoplasm http://purl.obolibrary.org/obo/DOID_1612 breast cancer A breast cancer that arises from myoepithelial cells, which are a normal constituent of the salivary acini and ducts and are found between the epithelial cells and the basement membrane. http://purl.obolibrary.org/obo/DOID_3013 intraductal breast benign neoplasm http://purl.obolibrary.org/obo/DOID_0060082 breast benign neoplasm A breast benign neoplasm that is located_in the breast ducts. http://purl.obolibrary.org/obo/DOID_302 substance abuse http://purl.obolibrary.org/obo/DOID_303 substance-related disorder A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning. http://purl.obolibrary.org/obo/DOID_303 substance-related disorder http://purl.obolibrary.org/obo/DOID_150 disease of mental health A disease of mental health involving the abuse or dependence on a substance that is ingested in order to produce a high, alter one's senses, or otherwise affect functioning. http://purl.obolibrary.org/obo/DOID_3044 food allergy http://purl.obolibrary.org/obo/DOID_0060502 gastrointestinal allergy A hypersensitivity reaction type I disease that is an abnormal response to a food, triggered by the body's immune system. http://purl.obolibrary.org/obo/DOID_305 carcinoma http://purl.obolibrary.org/obo/DOID_0050687 cell type cancer A cell type cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. http://purl.obolibrary.org/obo/DOID_3068 glioblastoma http://purl.obolibrary.org/obo/DOID_3069 astrocytoma An astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes. http://purl.obolibrary.org/obo/DOID_3070 malignant glioma http://purl.obolibrary.org/obo/DOID_184 bone cancer A cell type cancer that has_material_basis_in glial cells and is located in brain or located in spine. http://purl.obolibrary.org/obo/DOID_3082 interstitial lung disease http://purl.obolibrary.org/obo/DOID_850 lung disease A lung disease that is characterized by inflammation and altered lung interstitium compromising pulmonary function and often has_symptom shortness of breath, dyspnea, and/or cough. http://purl.obolibrary.org/obo/DOID_3093 nervous system cancer http://purl.obolibrary.org/obo/DOID_863 nervous system disease An organ system cancer located_in the nervous system that affects the central or peripheral nervous system. http://purl.obolibrary.org/obo/DOID_3117 hepatobiliary benign neoplasm http://purl.obolibrary.org/obo/DOID_0050624 gastrointestinal system benign neoplasm A gastrointestinal system benign neoplasm located_in the hepatobiliary system. http://purl.obolibrary.org/obo/DOID_3119 gastrointestinal system cancer http://purl.obolibrary.org/obo/DOID_77 gastrointestinal system disease An organ system cancer located_in gastrointestinal tract that is manifested in organs of the gastrointestinal system. http://purl.obolibrary.org/obo/DOID_3121 gallbladder cancer http://purl.obolibrary.org/obo/DOID_0060262 gallbladder disease A biliary tract cancer that is located_in the gallbladder. http://purl.obolibrary.org/obo/DOID_3133 acute porphyria http://purl.obolibrary.org/obo/DOID_13268 porphyria A porphyria that has_symptom abdominal pain, has_symptom neuropathy, has_symptom autonomic instability and has_symptom psychosis. http://purl.obolibrary.org/obo/DOID_3146 lipid metabolism disorder http://purl.obolibrary.org/obo/DOID_655 inherited metabolic disorder An inherited metabolic disorder that involves the creation and degradation of lipids. http://purl.obolibrary.org/obo/DOID_3168 squamous cell neoplasm http://purl.obolibrary.org/obo/DOID_0060084 cell type benign neoplasm A cell type benign neoplasm composed_of epithelial cells located_in the ectodermal or endodermal cells linking body cavities. http://purl.obolibrary.org/obo/DOID_3209 junctional epidermolysis bullosa http://purl.obolibrary.org/obo/DOID_2730 epidermolysis bullosa An epidermolysis bullosa that is characterized by recurrent blistering located in the lamina lucida of the basement membrane secondary to minor trauma, which can cause limited wounds, dehydration, electrolyte abnormalities, severe infection, among other issues, and has_material_basis_in mutation in genes related to laminin 332, which strengthens the skin. http://purl.obolibrary.org/obo/DOID_3211 lysosomal storage disease http://purl.obolibrary.org/obo/DOID_655 inherited metabolic disorder An inherited metabolic disorder that involve an abnormal accumulation of substances inside the lysosome resulting from defects in lysosomal function. http://purl.obolibrary.org/obo/DOID_3213 demyelinating disease http://purl.obolibrary.org/obo/DOID_1289 neurodegenerative disease A neurodegenerative disease that is characterized by damage to the myelin sheath present around nerve axons. http://purl.obolibrary.org/obo/DOID_3234 central nervous system lymphoma http://purl.obolibrary.org/obo/DOID_5772 central nervous system hematologic cancer A hematologic cancer that has_material_basis_in lymphoma located_in central nervous system. http://purl.obolibrary.org/obo/DOID_3246 embryonal rhabdomyosarcoma http://purl.obolibrary.org/obo/DOID_3247 rhabdomyosarcoma A rhabdomyosarcoma wherein the mesenchymally-derived malignant cells resemble the primitive developing skeletal muscle of the embryo; it occurs most often in the head and neck area or in the genital or urinary organs. http://purl.obolibrary.org/obo/DOID_326 ischemia http://purl.obolibrary.org/obo/DOID_178 vascular disease A vascular disease that is characterized by a restriction in blood supply to tissues. http://purl.obolibrary.org/obo/DOID_3277 thymus cancer http://purl.obolibrary.org/obo/DOID_170 endocrine gland cancer An immune system cancer located_in the thymus. http://purl.obolibrary.org/obo/DOID_3302 chordoma http://purl.obolibrary.org/obo/DOID_3303 notochordal cancer A notochordal cancer that derives_from cellular remnants of the notochord. http://purl.obolibrary.org/obo/DOID_331 central nervous system disease http://purl.obolibrary.org/obo/DOID_863 nervous system disease A nervous system disease that affects either the spinal cord (myelopathy) or brain (encephalopathy) of the central nervous system. http://purl.obolibrary.org/obo/DOID_3310 atopic dermatitis http://purl.obolibrary.org/obo/DOID_3042 allergic contact dermatitis An allergic contact dermatitis that is a chronically relapsing inflammatory allergic response located_in the skin that causes itching and flaking. http://purl.obolibrary.org/obo/DOID_3312 bipolar disorder http://purl.obolibrary.org/obo/DOID_3324 mood disorder A mood disorder that involves alternating periods of mania and depression. http://purl.obolibrary.org/obo/DOID_3315 lipoma http://purl.obolibrary.org/obo/DOID_0060084 cell type benign neoplasm A cell type benign neoplasm that is composed of lipocytes. http://purl.obolibrary.org/obo/DOID_332 amyotrophic lateral sclerosis http://purl.obolibrary.org/obo/DOID_231 motor neuron disease A motor neuron disease that is characterized by muscle spasticity, rapidly progressive weakness due to muscle atrophy, difficulty in speaking, swallowing, and breathing. http://purl.obolibrary.org/obo/DOID_3324 mood disorder http://purl.obolibrary.org/obo/DOID_1561 cognitive disorder A cognitive disorder that involves a disturbance in mood as the predominant underlying feature. http://purl.obolibrary.org/obo/DOID_3342 bone inflammation disease http://purl.obolibrary.org/obo/DOID_0080001 bone disease A bone disease that results_in inflammation of the located_in bone. http://purl.obolibrary.org/obo/DOID_3350 mesenchymal cell neoplasm http://purl.obolibrary.org/obo/DOID_0050687 cell type cancer A cell type cancer that has_material_basis_in abnormally proliferating cells derives from embryonic connective tissue that is capable of developing into connective tissue, such as bone, and cartilage, the lymphatic system, and the circulatory system. http://purl.obolibrary.org/obo/DOID_3369 Ewing sarcoma http://purl.obolibrary.org/obo/DOID_201 connective tissue cancer A connective tissue cancer that has_material_basis in neural crest cells derives_from undeveloped, undifferentiated neuroectoderm. http://purl.obolibrary.org/obo/DOID_3371 chondrosarcoma http://purl.obolibrary.org/obo/DOID_0080639 bone sarcoma A bone sarcoma that has_material_basis_in cells derived from transformed cells that produce cartilage. http://purl.obolibrary.org/obo/DOID_338 cranial nerve neoplasm http://purl.obolibrary.org/obo/DOID_5656 cranial nerve disease A central nervous system cancer develops from schwann cells located_in cranial nerves, has_material_basis_in abnormally proliferating cells. http://purl.obolibrary.org/obo/DOID_3388 periodontal disease http://purl.obolibrary.org/obo/DOID_403 mouth disease A mouth disease that is relating to or affecting the structures surrounding and supporting the teeth. http://purl.obolibrary.org/obo/DOID_3390 palmoplantar keratosis http://purl.obolibrary.org/obo/DOID_161 keratosis A keratosis characterized by abnormal thickening of the palms and the soles. http://purl.obolibrary.org/obo/DOID_3393 coronary artery disease http://purl.obolibrary.org/obo/DOID_0050828 artery disease An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles. http://purl.obolibrary.org/obo/DOID_341 peripheral vascular disease http://purl.obolibrary.org/obo/DOID_178 vascular disease A vascular disease that is characterized by obstruction of larger arteries not within the coronary, aortic arch vasculature, or brain. http://purl.obolibrary.org/obo/DOID_3418 glossopharyngeal nerve disease http://purl.obolibrary.org/obo/DOID_5656 cranial nerve disease A cranial nerve disease that is located_in the ninth cranial nerve or its nuclei in the medulla. http://purl.obolibrary.org/obo/DOID_3437 laryngitis http://purl.obolibrary.org/obo/DOID_786 laryngeal disease A laryngeal disease involving an inflammation of the larynx leading to hoarse voice or a complete loss of voice due to irritation of the vocal cords caused by viral, bacterial or fungal infection, inflammation due to overuse of the vocal cords and excessive coughing, smoking, or alcohol consumption. http://purl.obolibrary.org/obo/DOID_345 uterine disease http://purl.obolibrary.org/obo/DOID_229 female reproductive system disease A female reproductive system disease that is located_in the uterus. http://purl.obolibrary.org/obo/DOID_3451 skin carcinoma http://purl.obolibrary.org/obo/DOID_4159 skin cancer A skin cancer that is located_in tissues of the skin and develops from epithelial cells. http://purl.obolibrary.org/obo/DOID_3459 breast carcinoma http://purl.obolibrary.org/obo/DOID_1612 breast cancer A breast cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. http://purl.obolibrary.org/obo/DOID_3463 breast disease http://purl.obolibrary.org/obo/DOID_0060118 thoracic disease A thoracic disease that is located_in the breast. http://purl.obolibrary.org/obo/DOID_3479 uveal cancer http://purl.obolibrary.org/obo/DOID_3480 uveal disease An ocular cancer that is located_in the uvea, which are the pigmented layers of the eye consisting of the iris, ciliary body, and choroid. The uvea is the most common location of intraocular malignancy in adults and may commonly be caused by a subtype of cancer that arises from melanocytes. http://purl.obolibrary.org/obo/DOID_3480 uveal disease http://purl.obolibrary.org/obo/DOID_5614 eye disease An eye disease affecting the uvea, which are the pigmented layers of the eye consisting of the iris, ciliary body, and choroid. http://purl.obolibrary.org/obo/DOID_3482 plague http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that results_in infection, located_in lymph node, located_in vasculature or located_in lungs, has_material_basis_in Yersinia pestis, which is transmitted_by oriental rat flea (Xenopsylla cheopis) infected by feeding on rodents and other mammals, transmitted_by air, transmitted_by direct contact or transmitted_by ingestion of contaminated undercooked food. http://purl.obolibrary.org/obo/DOID_3490 Noonan syndrome http://purl.obolibrary.org/obo/DOID_0080690 RASopathy A RASopathy that is characterized by mildly unusual facial features, short stature, heart defects, bleeding problems, skeletal malformations, and many other signs and symptoms. http://purl.obolibrary.org/obo/DOID_3491 Turner syndrome http://purl.obolibrary.org/obo/DOID_14447 gonadal dysgenesis A gonadal dysgenesis that is characterized by short stature and early loss of ovarian function resulting from ovarian hypofunction or premature ovarian failure and has_material_basis_in one missing or structurally altered X chromosome. http://purl.obolibrary.org/obo/DOID_3541 cerebral ventricle cancer http://purl.obolibrary.org/obo/DOID_368 cerebrum cancer A cerebrum cancer that is located_in the cerebral ventricles. http://purl.obolibrary.org/obo/DOID_3565 meningioma http://purl.obolibrary.org/obo/DOID_3620 central nervous system cancer A central nervous system cancer that are manifested in the central nervous system and arise from the arachnoid cap cells of the arachnoid villi in the meninges. http://purl.obolibrary.org/obo/DOID_3620 central nervous system cancer http://purl.obolibrary.org/obo/DOID_331 central nervous system disease A nervous system cancer that is located_in the central nervous system. http://purl.obolibrary.org/obo/DOID_3627 aortic aneurysm http://purl.obolibrary.org/obo/DOID_520 aortic disease An aortic disease that is characterized by an enlargement (dilation) of the aorta to greater than 1.5 times normal size. http://purl.obolibrary.org/obo/DOID_363 uterine cancer http://purl.obolibrary.org/obo/DOID_345 uterine disease A female reproductive organ cancer that is located_in the uterus. http://purl.obolibrary.org/obo/DOID_365 bladder disease http://purl.obolibrary.org/obo/DOID_18 urinary system disease A urinary system disease that is located_in the bladder. http://purl.obolibrary.org/obo/DOID_3650 lactic acidosis http://purl.obolibrary.org/obo/DOID_0050758 metabolic acidosis A metabolic acidosis characterized by buildup of lactate. http://purl.obolibrary.org/obo/DOID_368 cerebrum cancer http://purl.obolibrary.org/obo/DOID_1659 supratentorial cancer A supratentorial cancer that is located_in the cerebrum. http://purl.obolibrary.org/obo/DOID_37 skin disease http://purl.obolibrary.org/obo/DOID_16 integumentary system disease An integumentary system disease that is located_in skin. http://purl.obolibrary.org/obo/DOID_3717 gastric adenocarcinoma http://purl.obolibrary.org/obo/DOID_299 adenocarcinoma A stomach carcinoma that derives_from epithelial cells of glandular origin. http://purl.obolibrary.org/obo/DOID_3753 Hermansky-Pudlak syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by oculocutaneous albinism, bleeding problems due to platelet storage pool defect, visual impairment and lysosomal accumulation of ceroid lipofuscin. http://purl.obolibrary.org/obo/DOID_3770 pulmonary fibrosis http://purl.obolibrary.org/obo/DOID_3082 interstitial lung disease An interstitial lung disease that is characterized by destruction, scarring, and thickening of the interstitial lung tissues and progressive pulmonary function loss in a restrictive pattern, has_symptom progressive shortness of breath, fatigue, and chronic cough, possibly has_material_basis_in exposure to certain chemicals, autoimmune conditions, and radiation. http://purl.obolibrary.org/obo/DOID_3798 pleural empyema http://purl.obolibrary.org/obo/DOID_1532 pleural disease A soft tissue infectious disease that involves accumulation of pus in the pleural cavity as a result of infection within the lung (pneumonia) or a lung abscess spreading into the space. The symptoms include cough, fever, chest pain, sweating and shortness of breath. http://purl.obolibrary.org/obo/DOID_381 arthropathy http://purl.obolibrary.org/obo/DOID_0080001 bone disease A bone disease that is located_in the joint. http://purl.obolibrary.org/obo/DOID_3856 male reproductive organ cancer http://purl.obolibrary.org/obo/DOID_48 male reproductive system disease A reproductive organ cancer that is manifested in the male genital system. This includes organs such as the penis and scrotum. http://purl.obolibrary.org/obo/DOID_3883 Lynch syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by an increased risk for colon cancer and cancers of the endometrium, ovary, stomach, small intestine, hepatobiliary tract, urinary tract, brain, and skin and has_material_basis_in mutation of mismatch repair genes that increases the risk of many types of cancers. http://purl.obolibrary.org/obo/DOID_3904 bronchus carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A bronchus cancer that has_material_basis_in epithelial cells. http://purl.obolibrary.org/obo/DOID_3905 lung carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A lung cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells and is located_in the lungs and has_symptom cough and has_symptom chest discomfort or pain and has_symptom weight loss and has_symptom hemoptysis. http://purl.obolibrary.org/obo/DOID_3930 otitis interna http://purl.obolibrary.org/obo/DOID_2952 inner ear disease An inner ear disease which involves inflammation of the inner ear. http://purl.obolibrary.org/obo/DOID_3963 thyroid gland carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma A thyroid gland cancer that has_material_basis_in epithelial cells. http://purl.obolibrary.org/obo/DOID_397 restrictive cardiomyopathy http://purl.obolibrary.org/obo/DOID_0060036 intrinsic cardiomyopathy An intrinsic cardiomyopathy characterized by impaired ventricular filling, with normal or decreased diastolic volume of either or both ventricles typically resulting from increased stiffness of the myocardium. http://purl.obolibrary.org/obo/DOID_3973 thyroid gland medullary carcinoma http://purl.obolibrary.org/obo/DOID_3963 thyroid gland carcinoma A thyroid gland carcinoma that has_material_basis_in parafollicular cells. http://purl.obolibrary.org/obo/DOID_3978 extrinsic cardiomyopathy http://purl.obolibrary.org/obo/DOID_0050700 cardiomyopathy A cardiomyopathy that is characterized by the pathology occuring outside of the myocardium. http://purl.obolibrary.org/obo/DOID_399 tuberculosis http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes. http://purl.obolibrary.org/obo/DOID_3996 urinary system cancer http://purl.obolibrary.org/obo/DOID_18 urinary system disease An organ system cancer that is located_in the kidneys, ureteres, bladder or urethra. http://purl.obolibrary.org/obo/DOID_4001 ovarian carcinoma http://purl.obolibrary.org/obo/DOID_2151 malignant ovarian surface epithelial-stromal neoplasm An ovarian cancer that has_material_basis_in epithelial tissue and is located_in the ovary. http://purl.obolibrary.org/obo/DOID_403 mouth disease http://purl.obolibrary.org/obo/DOID_77 gastrointestinal system disease A gastrointestinal system disease that is located_in the mouth. http://purl.obolibrary.org/obo/DOID_404 gastrointestinal tuberculosis http://purl.obolibrary.org/obo/DOID_0050599 abdominal tuberculosis An abdominal tuberculosis that results_in infection located_in gastrointestinal tract. The infection has_symptom abdominal pain, has_symptom weight loss, has_symptom fever, has_symptom anorexia, has_symptom change in bowel habits, has_symptom nausea, and has_symptom vomiting. http://purl.obolibrary.org/obo/DOID_4045 muscle cancer http://purl.obolibrary.org/obo/DOID_0080000 muscular disease A musculoskeletal system cancer that is located_in muscle. http://purl.obolibrary.org/obo/DOID_4079 heart valve disease http://purl.obolibrary.org/obo/DOID_114 heart disease A heart disease involving one or more of the four valves of the heart (the aortic and mitral valves on the left and the pulmonary and tricuspid valves on the right). http://purl.obolibrary.org/obo/DOID_4090 agnosia http://purl.obolibrary.org/obo/DOID_2033 communication disorder A communication disorder that is a loss of ability to recognize objects, persons, sounds, shapes, or smells while the specific sense is not defective nor is there any significant memory loss. http://purl.obolibrary.org/obo/DOID_4109 tick infestation http://purl.obolibrary.org/obo/DOID_4110 parasitic ectoparasitic infectious disease A parasitic ectoparasitic infectious disease that involves parasitic infestation of blood feeding ticks of the families Ixodidae and Argasidae on animals and humans. Ticks are vectors of a number diseases, including Lyme disease, Q fever, Colorado tick fever, tularemia, tick-borne relapsing fever, babesiosis, ehrlichiosis and tick-borne meningoencephalitis, as well as anaplasmosis in cattle and canine jaundice. http://purl.obolibrary.org/obo/DOID_4110 parasitic ectoparasitic infectious disease http://purl.obolibrary.org/obo/DOID_1398 parasitic infectious disease A parasitic infectious disease that is caused by organisms that live primarily on the surface of the host. http://purl.obolibrary.org/obo/DOID_4123 nail disease http://purl.obolibrary.org/obo/DOID_16 integumentary system disease An integumentary system disease that is located_in nail. http://purl.obolibrary.org/obo/DOID_4159 skin cancer http://purl.obolibrary.org/obo/DOID_37 skin disease An integumentary system cancer located_in the skin that is the uncontrolled growth of abnormal skin cells. http://purl.obolibrary.org/obo/DOID_417 autoimmune disease http://purl.obolibrary.org/obo/DOID_612 primary immunodeficiency disease An immune system disease that is an overactive immune response of the body against substances and tissues normally present in the body resulting from an abnormal functioning of the immune system that results in the production of antibodies or T cell directed against the host tissues. http://purl.obolibrary.org/obo/DOID_418 systemic scleroderma http://purl.obolibrary.org/obo/DOID_419 scleroderma A scleroderma that is characterized by fibrosis (or hardening) of the skin and major organs, as well as vascular alterations, and autoantibodies. http://purl.obolibrary.org/obo/DOID_4186 articulation disorder http://purl.obolibrary.org/obo/DOID_92 speech disorder A speech disorder that involves mispronouncing speech sounds by omitting, distorting, substituting, or adding sounds which can make speech difficult to understand. http://purl.obolibrary.org/obo/DOID_420 hypertrichosis http://purl.obolibrary.org/obo/DOID_421 hair disease A hair disease characterized by hair growth that is abnormal in quantity or location. http://purl.obolibrary.org/obo/DOID_4223 pyoderma http://purl.obolibrary.org/obo/DOID_2723 dermatitis A dermatitis that is characterized by a pyogenic infection causing the formation of pus. http://purl.obolibrary.org/obo/DOID_423 myopathy http://purl.obolibrary.org/obo/DOID_66 muscle tissue disease A muscular disease in which the muscle fibers do not function resulting in muscular weakness. http://purl.obolibrary.org/obo/DOID_4251 conjunctival disease http://purl.obolibrary.org/obo/DOID_5614 eye disease An eye disease affecting the conjunctiva, which is the mucous membrane surrounding the eye and interior of the eyelids. http://purl.obolibrary.org/obo/DOID_4254 osteosclerosis http://purl.obolibrary.org/obo/DOID_0080005 bone remodeling disease A bone remodeling disease that results_in abnormal elevated bone density or mass. http://purl.obolibrary.org/obo/DOID_4337 tinea capitis http://purl.obolibrary.org/obo/DOID_8913 dermatophytosis A dermatophytosis that results_in contagious fungal infection located_in scalp, located_in hair of head, located_in eyebrow or located_in eyelash, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes and has_symptom itching of the scalp, has_symptom pus filled lesions on the scalp, and has_symptom patches of hair loss, sometimes with a 'black dot' pattern. http://purl.obolibrary.org/obo/DOID_437 myasthenia gravis http://purl.obolibrary.org/obo/DOID_438 autoimmune disease of the nervous system An autoimmune disease of the nervous system that has_material_basis_in antibodies to acetylcholine receptors at the neuromuscular junction, has_symptom ptosis, has_symptom diplopia, has_symptom dysphagia, has_symptom dysarthria, has_symptom muscle weakness and has_symptom shortness of breath. http://purl.obolibrary.org/obo/DOID_4377 egg allergy http://purl.obolibrary.org/obo/DOID_3044 food allergy A food allergy that is an allergy or hypersensitivity to dietary substances from the yolk or whites of eggs, causing an overreaction of the immune system which may lead to severe physical symptoms. http://purl.obolibrary.org/obo/DOID_438 autoimmune disease of the nervous system http://purl.obolibrary.org/obo/DOID_863 nervous system disease An autoimmune disease affecting the nervous system. http://purl.obolibrary.org/obo/DOID_439 neuromuscular junction disease http://purl.obolibrary.org/obo/DOID_440 neuromuscular disease A neuromuscular disease that is characterized by the disfunction of conduction through the neuromuscular junction. http://purl.obolibrary.org/obo/DOID_440 neuromuscular disease http://purl.obolibrary.org/obo/DOID_870 neuropathy A neuropathy that affect the nerves that control the voluntary muscles. http://purl.obolibrary.org/obo/DOID_4448 macular degeneration http://purl.obolibrary.org/obo/DOID_8466 retinal degeneration A retinal degeneration characterized by gradual deterioration of light-sensing cells in the tissues at the back of the eye and has_symptom vision loss. http://purl.obolibrary.org/obo/DOID_446 primary hyperaldosteronism http://purl.obolibrary.org/obo/DOID_3947 adrenal gland hyperfunction An adrenal gland hyperfunction disease that results in the overproduction of aldosterone by the adrenal glands. http://purl.obolibrary.org/obo/DOID_450 myotonic disease http://purl.obolibrary.org/obo/DOID_9884 muscular dystrophy A muscular dystrophy that is characterized by progressive muscle wasting and weakness. http://purl.obolibrary.org/obo/DOID_4501 orofaciodigital syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by malformations of the face, oral cavity, and digits. http://purl.obolibrary.org/obo/DOID_4531 mucoepidermoid carcinoma http://purl.obolibrary.org/obo/DOID_0050904 salivary gland carcinoma A salivary gland carcinoma that is characterized by squamous cells, mucus-secreting cells, and intermediate cells. http://purl.obolibrary.org/obo/DOID_4535 hypotrichosis http://purl.obolibrary.org/obo/DOID_421 hair disease A hair disease that is characterized by sparse hair on the scalp resulting from abnormal hair follicle development and has_material_basis in mutations in proteins involved in hair growth, division or proliferation of cells within hair follicles. http://purl.obolibrary.org/obo/DOID_4606 bile duct cancer http://purl.obolibrary.org/obo/DOID_4138 bile duct disease A biliary tract cancer that is located_in the bile duct. http://purl.obolibrary.org/obo/DOID_4610 intestinal benign neoplasm http://purl.obolibrary.org/obo/DOID_5295 intestinal disease A gastrointestinal system benign neoplasm that is located_in the intestine. http://purl.obolibrary.org/obo/DOID_4644 epidermolysis bullosa simplex http://purl.obolibrary.org/obo/DOID_2730 epidermolysis bullosa An epidermolysis bullosa that is characterized by recurrent blistering at the level of the epidermis secondary to minor trauma, which can cause limited wounds, dehydration, electrolyte abnormalities, severe infection, among other issues, and has_material_basis_in mutation in the KRT5, KRT14, or PLEC genes, which encode keratin and plectin proteins that provide resilience in skin. http://purl.obolibrary.org/obo/DOID_4677 keratitis http://purl.obolibrary.org/obo/DOID_10124 corneal disease A corneal disease that is characterized by inflammation of the cornea. http://purl.obolibrary.org/obo/DOID_4706 infratentorial cancer http://purl.obolibrary.org/obo/DOID_1319 brain cancer A brain cancer that is located_in the infratentorial region. http://purl.obolibrary.org/obo/DOID_4737 somatoform disorder http://purl.obolibrary.org/obo/DOID_150 disease of mental health A disease of mental health that involves physical symptoms suggesting a physical illness where the biological or medical cause of the symptoms is indeterminate. http://purl.obolibrary.org/obo/DOID_48 male reproductive system disease http://purl.obolibrary.org/obo/DOID_15 reproductive system disease A reproductive system disease that affects male reproductive organs. http://purl.obolibrary.org/obo/DOID_480 movement disease http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is characterized by a clinical syndrome of either hyperkinetic movement or hyperkinetic movement unrelated to weakness or spasticity. http://purl.obolibrary.org/obo/DOID_4866 salivary gland adenoid cystic carcinoma http://purl.obolibrary.org/obo/DOID_0050904 salivary gland carcinoma A salivary gland carcinoma that is characterized by a distinctive pattern in which abnormal nests or cords of epithelial cells surround and/or infiltrate ducts or glandular structures within the affected organ. These structures are typically filled with a mucous-like material or contain abnormal fibrous membranes. http://purl.obolibrary.org/obo/DOID_4906 small intestine adenocarcinoma http://purl.obolibrary.org/obo/DOID_299 adenocarcinoma A small intestine carcinoma that derives_from epithelial cells of glandular origin. http://purl.obolibrary.org/obo/DOID_4939 ureter carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma An ureter cancer that is located_in the ureter. http://purl.obolibrary.org/obo/DOID_4953 poliomyelitis http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results in destruction located in motor neurons, has_material_basis_in Human poliovirus 1, has_material_basis_in Human poliovirus 2, or has_material_basis_in Human poliovirus 3, which are transmitted by ingestion of food or water contaminated with feces, or transmitted by direct contact with the oral secretions. The infection has symptom fever, has symptom sore throat, has symptom headache, has symptom vomiting, has symptom fatigue, has symptom neck stiffness, has symptom muscle spasms, and has symptom acute flaccid paralysis. http://purl.obolibrary.org/obo/DOID_4960 bone marrow cancer http://purl.obolibrary.org/obo/DOID_2531 hematologic cancer A hematopoietic cancer that derives_from the blood-forming stem cells of the bone marrow. http://purl.obolibrary.org/obo/DOID_4972 myelodysplastic/myeloproliferative neoplasm http://purl.obolibrary.org/obo/DOID_0070004 myeloid neoplasm A myeloid neoplasm that results_in the overproduction of white blood cells. http://purl.obolibrary.org/obo/DOID_50 thyroid gland disease http://purl.obolibrary.org/obo/DOID_28 endocrine system disease An endocrine system disease that is located_in the thyroid. http://purl.obolibrary.org/obo/DOID_5032 pineal gland cancer http://purl.obolibrary.org/obo/DOID_170 endocrine gland cancer An endocrine gland located_in the pineal gland located in the brain. http://purl.obolibrary.org/obo/DOID_5041 esophageal cancer http://purl.obolibrary.org/obo/DOID_6050 esophageal disease A gastrointestinal system cancer that is located_in the esophagus. http://purl.obolibrary.org/obo/DOID_5093 thoracic cancer http://purl.obolibrary.org/obo/DOID_0060118 thoracic disease An organ system cancer located_in the thoracic cavity that develops in the different types of cells within the lungs, as well as less common cancers of the esophagus, the trachea, or the chest wall. http://purl.obolibrary.org/obo/DOID_5113 nutritional deficiency disease http://purl.obolibrary.org/obo/DOID_374 nutrition disease A nutrition disease that is characterized by deficiency of a nutritional element, such as a vitamin, mineral, carbohydrate, protein, fat, or general energy content. http://purl.obolibrary.org/obo/DOID_5158 pleural cancer http://purl.obolibrary.org/obo/DOID_201 connective tissue cancer A connective tissue cancer that located_in the pleura. http://purl.obolibrary.org/obo/DOID_520 aortic disease http://purl.obolibrary.org/obo/DOID_0050828 artery disease An artery disease that is characterized by degeneration of the cells composing the aortic wall. http://purl.obolibrary.org/obo/DOID_5212 congenital disorder of glycosylation http://purl.obolibrary.org/obo/DOID_2978 carbohydrate metabolic disorder A carbohydrate metabolic disorder that involves deficient or defective glycosylation of a variety of tissue proteins and/or lipids. http://purl.obolibrary.org/obo/DOID_5295 intestinal disease http://purl.obolibrary.org/obo/DOID_77 gastrointestinal system disease A gastrointestinal system disease that is located_in the intestine. http://purl.obolibrary.org/obo/DOID_53 pituitary gland disease http://purl.obolibrary.org/obo/DOID_28 endocrine system disease An endocrine system disease that is located_in the pituitary gland. http://purl.obolibrary.org/obo/DOID_530 eyelid disease http://purl.obolibrary.org/obo/DOID_37 skin disease An adnexa disease that is located_in the eyelid. http://purl.obolibrary.org/obo/DOID_535 sleep disorder http://purl.obolibrary.org/obo/DOID_150 disease of mental health A disease of mental health that involves disruption of sleep patterns. http://purl.obolibrary.org/obo/DOID_5353 colonic disease http://purl.obolibrary.org/obo/DOID_5295 intestinal disease A intestinal disease located in the colon. http://purl.obolibrary.org/obo/DOID_540 strabismus http://purl.obolibrary.org/obo/DOID_1279 ocular motility disease A hyperopia that is characterized by eyes that do not properly align with each other when looking at an object. http://purl.obolibrary.org/obo/DOID_5409 lung small cell carcinoma http://purl.obolibrary.org/obo/DOID_3905 lung carcinoma A lung carcinoma that has_material_basis_in primitive-appearing cells that are smaller than normal cells and is located_in the lung. http://purl.obolibrary.org/obo/DOID_5419 schizophrenia http://purl.obolibrary.org/obo/DOID_2468 psychotic disorder A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness. http://purl.obolibrary.org/obo/DOID_5502 lice infestation http://purl.obolibrary.org/obo/DOID_4110 parasitic ectoparasitic infectious disease A parasitic ectoparasitic infectious disease that involves infestation of lice, which are blood-feeding ectoparasitic insects of the order Phthiraptera. http://purl.obolibrary.org/obo/DOID_552 pneumonia http://purl.obolibrary.org/obo/DOID_850 lung disease A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. It is accompanied by fever, chills, cough, and difficulty in breathing. http://purl.obolibrary.org/obo/DOID_557 kidney disease http://purl.obolibrary.org/obo/DOID_18 urinary system disease A urinary system disease that is located_in the kidney. http://purl.obolibrary.org/obo/DOID_5604 adult acute lymphocytic leukemia http://purl.obolibrary.org/obo/DOID_9952 acute lymphoblastic leukemia An acute lymphocytic leukemia occurring during adulthood. http://purl.obolibrary.org/obo/DOID_5612 spinal cancer http://purl.obolibrary.org/obo/DOID_3620 central nervous system cancer A central nervous system cancer that is located_in the spinal cord. It is mostly formed from metastases from primary cancers elsewhere (commonly breast, prostate, and lung cancer). http://purl.obolibrary.org/obo/DOID_5614 eye disease http://purl.obolibrary.org/obo/DOID_0050155 sensory system disease An eye and adnexa disease that is located_in the eye. http://purl.obolibrary.org/obo/DOID_5656 cranial nerve disease http://purl.obolibrary.org/obo/DOID_870 neuropathy A neuropathy that is located_in one of the twelve cranial nerves. http://purl.obolibrary.org/obo/DOID_5672 large intestine cancer http://purl.obolibrary.org/obo/DOID_10155 intestinal cancer An intestinal cancer that effects the long, tube-like organ that is connected to the small intestine at one end and the anus at the other. http://purl.obolibrary.org/obo/DOID_5679 retinal disease http://purl.obolibrary.org/obo/DOID_5614 eye disease An eye disease that is located_in the retina. http://purl.obolibrary.org/obo/DOID_5723 optic atrophy http://purl.obolibrary.org/obo/DOID_1891 optic nerve disease An optic nerve disease that is characterized the death of the retinal ganglion cell axons that comprise the optic nerve. http://purl.obolibrary.org/obo/DOID_5733 salpingitis http://purl.obolibrary.org/obo/DOID_1962 fallopian tube disease A fallopian tube disease that is characterized by inflammation of the fallopian tube. http://purl.obolibrary.org/obo/DOID_574 peripheral nervous system disease http://purl.obolibrary.org/obo/DOID_863 nervous system disease A nervous system disease that affects the peripheral nervous system. http://purl.obolibrary.org/obo/DOID_5772 central nervous system hematologic cancer http://purl.obolibrary.org/obo/DOID_3620 central nervous system cancer A hematologic cancer and central nervous system neoplasm that is located_in the central nervous system. http://purl.obolibrary.org/obo/DOID_5875 retroperitoneal cancer http://purl.obolibrary.org/obo/DOID_0050686 organ system cancer An organ system cancer located_in the retroperitoneal space that is manifested in retroperitoneal space in the abdominal cavity behind the peritoneum. http://purl.obolibrary.org/obo/DOID_591 phobic disorder http://purl.obolibrary.org/obo/DOID_2030 anxiety disorder An anxiety disorder where fear and anxiety are triggered by a specific stimulus or situation. http://purl.obolibrary.org/obo/DOID_599 specific phobia http://purl.obolibrary.org/obo/DOID_591 phobic disorder A phobic disorder that is characterized by an unreasonable or irrational fear related to exposure to specific objects or situations. http://purl.obolibrary.org/obo/DOID_6000 congestive heart failure http://purl.obolibrary.org/obo/DOID_114 heart disease A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body. http://purl.obolibrary.org/obo/DOID_6025 selective immunoglobulin deficiency disease http://purl.obolibrary.org/obo/DOID_2115 B cell deficiency A B cell deficiency that is characterized by deficiency of an immunoglobulin subtype. The clinical course and prognosis is dependent upon the severity of the selective deficiency and associated morbidity. http://purl.obolibrary.org/obo/DOID_6050 esophageal disease http://purl.obolibrary.org/obo/DOID_77 gastrointestinal system disease A gastrointestinal system disease that is located_in the esophagus. http://purl.obolibrary.org/obo/DOID_612 primary immunodeficiency disease http://purl.obolibrary.org/obo/DOID_2914 immune system disease An immune system disease that results when one or more essential parts of the immune system is missing or not working properly at birth due to a genetic mutation. http://purl.obolibrary.org/obo/DOID_615 leukopenia http://purl.obolibrary.org/obo/DOID_9500 leukocyte disease A leukocyte disorder that is characterized by a decrease in the number of white blood cells (leukocytes) found in the blood, which places individuals at increased risk of infection. http://purl.obolibrary.org/obo/DOID_6195 conjunctivitis http://purl.obolibrary.org/obo/DOID_4251 conjunctival disease A conjunctival disease characterized by an inflammation of the conjunctiva, the outermost layer of the eye and the inner surface of the eyelids. http://purl.obolibrary.org/obo/DOID_626 complement deficiency http://purl.obolibrary.org/obo/DOID_612 primary immunodeficiency disease A primary immunodeficiency disease that is the result in a mutation of a gene encoding one of the thirty complement system proteins, produced predominantly in liver, which function to defend against infection and produce inflammation. http://purl.obolibrary.org/obo/DOID_627 severe combined immunodeficiency http://purl.obolibrary.org/obo/DOID_0111962 combined immunodeficiency A combined T cell and B cell immunodeficiency that is caused by a defect in infection-fighting immune cells resulting in individuals with non-functional immune systems. http://purl.obolibrary.org/obo/DOID_628 combined T cell and B cell immunodeficiency http://purl.obolibrary.org/obo/DOID_0111962 combined immunodeficiency A primary immunodeficiency disease characterized by impaired T cell-mediated immunity and impaired B cell mediated humoral immunity. http://purl.obolibrary.org/obo/DOID_630 genetic disease http://purl.obolibrary.org/obo/DOID_4 disease A disease that has_material_basis_in genetic variations in the human genome. http://purl.obolibrary.org/obo/DOID_633 myositis http://purl.obolibrary.org/obo/DOID_423 myopathy A myopathy characterized by muscle inflammation. http://purl.obolibrary.org/obo/DOID_6364 migraine http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing. http://purl.obolibrary.org/obo/DOID_639 acute disseminated encephalomyelitis http://purl.obolibrary.org/obo/DOID_640 encephalomyelitis An encephalomyelitis characterized by inflammation located in brain and located in spinal cord that damages myelin. It usually occurs after viral infection, but also following vaccination, bacterial or parasitic infection. http://purl.obolibrary.org/obo/DOID_6432 pulmonary hypertension http://purl.obolibrary.org/obo/DOID_10763 hypertension A hypertension characterized by an increase of blood pressure in the pulmonary artery, pulmonary vein or pulmonary capillaries. http://purl.obolibrary.org/obo/DOID_646 viral encephalitis http://purl.obolibrary.org/obo/DOID_9588 encephalitis An encephalitis that involves inflammation of the brain caused by viral infection. http://purl.obolibrary.org/obo/DOID_6460 large intestine lipoma http://purl.obolibrary.org/obo/DOID_4610 intestinal benign neoplasm An intestinal benign neoplasm that derives_from fat cells and that is located_in the large intestine. http://purl.obolibrary.org/obo/DOID_649 prion disease http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is characterized by brain damage resulting from the abnormal folding, clumping and accumulation of cellular proteins in the brain induced by prion proteins. http://purl.obolibrary.org/obo/DOID_65 connective tissue disease http://purl.obolibrary.org/obo/DOID_17 musculoskeletal system disease A musculoskeletal system disease that affects tissues such as skin, tendons, and cartilage. http://purl.obolibrary.org/obo/DOID_653 purine-pyrimidine metabolic disorder http://purl.obolibrary.org/obo/DOID_655 inherited metabolic disorder An inherited metabolic disorder involving dysfunction of purine and pyrimidine metabolism. http://purl.obolibrary.org/obo/DOID_654 overnutrition http://purl.obolibrary.org/obo/DOID_374 nutrition disease A nutrition disease that is characterized by an excess of a nutritional element, such as a vitamin, mineral, carbohydrate, protein, fat, or general energy content. http://purl.obolibrary.org/obo/DOID_655 inherited metabolic disorder http://purl.obolibrary.org/obo/DOID_0014667 disease of metabolism A disease of metabolism that is characterized by enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to inherited enzyme abnormality. http://purl.obolibrary.org/obo/DOID_656 adrenal adenoma http://purl.obolibrary.org/obo/DOID_9553 adrenal gland disease An endocrine organ benign neoplasm that is a benign tumor of the glandular type (adenoma) in the adrenal gland. http://purl.obolibrary.org/obo/DOID_657 adenoma http://purl.obolibrary.org/obo/DOID_0060084 cell type benign neoplasm A cell type benign neoplasm that is composed_of epithelial tissue in which tumor cells form glands or glandlike structures. http://purl.obolibrary.org/obo/DOID_6688 autoimmune lymphoproliferative syndrome http://purl.obolibrary.org/obo/DOID_2916 hypersensitivity reaction type IV disease A hypersensitivity reaction type IV disease that is an inherited disorder in which the body cannot properly regulate the number of immune system cells (lymphocytes). It is characterized by the production of an abnormally large number of lymphocytes. Accumulation of excess lymphocytes results in enlargement of the lymph nodes, the liver, and the spleen. http://purl.obolibrary.org/obo/DOID_6713 cerebrovascular disease http://purl.obolibrary.org/obo/DOID_936 brain disease An vascular disease that is characterized by dysfunction of the blood vessels supplying the brain. http://purl.obolibrary.org/obo/DOID_672 spleen cancer http://purl.obolibrary.org/obo/DOID_2529 splenic disease A lymphatic system cancer that affects white blood cells and involves tumor deposits in the spleen. http://purl.obolibrary.org/obo/DOID_674 cleft palate http://purl.obolibrary.org/obo/DOID_0050567 orofacial cleft An orofacial cleft characterized by a fissure of the soft and/or hard palate, due to faulty fusion of the two plates of the skull that form the hard palate. http://purl.obolibrary.org/obo/DOID_679 basal ganglia disease http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is characterized by dysfunctional movement, located_in basal ganglia with_material_basis_in diseased components of the basal ganglia and associated neural circuits. http://purl.obolibrary.org/obo/DOID_680 tauopathy http://purl.obolibrary.org/obo/DOID_1289 neurodegenerative disease A neurodegenerative disease that has_material_basis_in the pathological aggregation of tau protein in so-called neurofibrillary tangles (NFT) in the human brain. http://purl.obolibrary.org/obo/DOID_699 mitochondrial myopathy http://purl.obolibrary.org/obo/DOID_423 myopathy A myopathy that is characterized by mitochondrial dysfunction. http://purl.obolibrary.org/obo/DOID_7 disease of anatomical entity http://purl.obolibrary.org/obo/DOID_4 disease A disease that manifests in a defined anatomical structure. http://purl.obolibrary.org/obo/DOID_700 mitochondrial metabolism disease http://purl.obolibrary.org/obo/DOID_655 inherited metabolic disorder An inherited metabolic disorder that involves mitochondrial metabolism dysfunction. http://purl.obolibrary.org/obo/DOID_707 B-cell lymphoma http://purl.obolibrary.org/obo/DOID_0060060 non-Hodgkin lymphoma A non-Hodgkin lymphoma that has_material_basis_in B cells. http://purl.obolibrary.org/obo/DOID_731 urinary system benign neoplasm http://purl.obolibrary.org/obo/DOID_18 urinary system disease An organ system benign neoplasm that is located_in the kidneys, ureteres, bladder or urethra. http://purl.obolibrary.org/obo/DOID_732 urethral disease http://purl.obolibrary.org/obo/DOID_18 urinary system disease A urinary system disease that is located_in the urethra. http://purl.obolibrary.org/obo/DOID_74 hematopoietic system disease http://purl.obolibrary.org/obo/DOID_7 disease of anatomical entity A disease of anatomical entity that has_material_basis_in hematopoietic cells. http://purl.obolibrary.org/obo/DOID_7427 anthrax disease http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that results_in infection located_in skin, located_in lung lymph nodes or located_in gastrointestinal tract, has_material_basis_in Bacillus anthracis, transmitted_by contact with infected animals or animal products, transmitted_by airborne spores or transmitted_by ingestion of undercooked meat from infected animals and has_symptom skin ulcer, has_symptom nausea, has_symptom poor appetite, has_symptom bloody diarrhea, has_symptom fever or has_symptom shortness of breath. http://purl.obolibrary.org/obo/DOID_7475 diverticulitis http://purl.obolibrary.org/obo/DOID_5295 intestinal disease An intestinal disease characterized by the formation and inflammation of diverticula within the bowel wall. http://purl.obolibrary.org/obo/DOID_75 lymphatic system disease http://purl.obolibrary.org/obo/DOID_2914 immune system disease An immune system disease that is located_in the lymphatic system. http://purl.obolibrary.org/obo/DOID_7551 gonorrhea http://purl.obolibrary.org/obo/DOID_732 urethral disease A primary bacterial infectious disease that is a sexually transmitted infection, located_in uterus, located_in fallopian tube, located_in urethra, located_in mouth, located_in throat, located_in eye or located_in anus, has_material_basis_in Neisseria gonorrhoeae, which is transmitted_by contact with the penis, vagina, mouth, or anus or transmitted_by congenitally from mother to baby during delivery. The infection has_symptom burning sensation during urination, has_symptom discharge from the penis, has_symptom increased vaginal discharge, or has_symptom vaginal bleeding between periods. http://purl.obolibrary.org/obo/DOID_76 stomach disease http://purl.obolibrary.org/obo/DOID_77 gastrointestinal system disease A gastrointestinal system disease that is located_in the stomach. http://purl.obolibrary.org/obo/DOID_769 neuroblastoma http://purl.obolibrary.org/obo/DOID_2621 autonomic nervous system neoplasm An autonomic nervous system neoplasm that derives_from immature nerve cells. http://purl.obolibrary.org/obo/DOID_77 gastrointestinal system disease http://purl.obolibrary.org/obo/DOID_7 disease of anatomical entity A disease of anatomical entity that is located_in the gastrointestinal tract. http://purl.obolibrary.org/obo/DOID_780 placenta disease http://purl.obolibrary.org/obo/DOID_345 uterine disease A uterine disease that is located_in the placenta. http://purl.obolibrary.org/obo/DOID_7997 thyrotoxicosis http://purl.obolibrary.org/obo/DOID_50 thyroid gland disease A thyroid gland disease that is characterized by excess thyroid hormone. http://purl.obolibrary.org/obo/DOID_7998 hyperthyroidism http://purl.obolibrary.org/obo/DOID_50 thyroid gland disease A thyroid gland disease that involves an over production of thyroid hormone. http://purl.obolibrary.org/obo/DOID_811 lipodystrophy http://purl.obolibrary.org/obo/DOID_65 connective tissue disease A connective tissue disease that is characterized by marked reduction, absence, and/or the redistribution of adipose tissue. http://purl.obolibrary.org/obo/DOID_8125 osteochondrosis http://purl.obolibrary.org/obo/DOID_0080008 ischemic bone disease An ischemic bone disease that results_in necrosis followed by regrowth in children and teens located_in bone. http://purl.obolibrary.org/obo/DOID_8200 tertiary syphilis http://purl.obolibrary.org/obo/DOID_4166 syphilis A syphilis that is characterized as the third stage of syphilis that develops after the disappearance of the secondary symptoms and is marked by ulcers and gummas under the skin and commonly by involvement of the skeletal, cardiovascular, and nervous systems. http://purl.obolibrary.org/obo/DOID_8283 peritonitis http://purl.obolibrary.org/obo/DOID_77 gastrointestinal system disease A gastrointestinal system disease that involves inflammation of the peritoneum resulting from perforation of the gastrointestinal tract, which produces immediate chemical inflammation followed shortly by infection from intestinal organisms. Peritonitis can also result from appendicitis, diverticulitis, strangulating intestinal obstruction, pancreatitis, pelvic inflammatory disease, mesenteric ischemia, intraperitoneal blood, barium, or peritoneo-systemic shunts, drains, and dialysis catheters in the peritoneal cavity. The symptoms include abdominal pain and tenderness, fever, fluid in the abdomen, nausea, vomiting and low urine output. http://purl.obolibrary.org/obo/DOID_8295 scabies http://purl.obolibrary.org/obo/DOID_7894 mite infestation A mite infestation that is a contagious ectoparasite skin infection caused by human itch mite Sarcoptes scabiei type hominis, which burrows into the upper layer of the skin but never below the stratum corneum causing severe itching and a rash found on the hands, folds of the wrist, elbow or knee, penis, breast, and shoulder blades. http://purl.obolibrary.org/obo/DOID_83 cataract http://purl.obolibrary.org/obo/DOID_110 lens disease A lens disease characterized by clouding of the lens inside the eye which leads to a decrease in vision. http://purl.obolibrary.org/obo/DOID_841 extrinsic allergic alveolitis http://purl.obolibrary.org/obo/DOID_3082 interstitial lung disease An interstitial lung disease involving inflammation of alveoli and smallest airways (bronchioles) of the lung caused by an allergic reaction to inhaled organic dusts containing microorganisms or proteins, and chemicals. Symptoms include chills, cough, fever, malaise, shortness of breath, loss of appetite and weight loss. http://purl.obolibrary.org/obo/DOID_8432 polycythemia http://purl.obolibrary.org/obo/DOID_4961 bone marrow disease A bone marrow disease characterized by an increased number of red blood cells in the bloodstream resulting in thicker blood and reduced blood flow. http://purl.obolibrary.org/obo/DOID_8466 retinal degeneration http://purl.obolibrary.org/obo/DOID_9799 eye degenerative disease A retinal disease that is characterized by deterioration of the retina caused by the progressive and eventual death of the cells of the retina. http://purl.obolibrary.org/obo/DOID_8469 influenza http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results in infection, located in respiratory tract, has_material_basis_in Influenzavirus A, has_material_basis_in Influenzavirus B, or has_material_basis_in Influenzavirus C, which are transmitted_by droplet spread of oronasal secretions during coughing, sneezing, or talking from an infected person. It is a highly contagious disease that affects birds and mammals and has_symptom chills, has_symptom fever, has_symptom sore throat, has_symptom runny nose, has_symptom muscle pains, has_symptom severe headache, has_symptom cough, and has_symptom weakness. http://purl.obolibrary.org/obo/DOID_848 arthritis http://purl.obolibrary.org/obo/DOID_3342 bone inflammation disease A bone inflammation disease that involves a response to irritation or injury, characterized by joint pain, swelling, stiffness located_in joint. http://purl.obolibrary.org/obo/DOID_8499 night blindness http://purl.obolibrary.org/obo/DOID_5679 retinal disease A retinal disease that is characterized by difficulty or the inability to see in relatively low light. http://purl.obolibrary.org/obo/DOID_850 lung disease http://purl.obolibrary.org/obo/DOID_0050161 lower respiratory tract disease A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide. http://purl.obolibrary.org/obo/DOID_8502 bullous skin disease http://purl.obolibrary.org/obo/DOID_65 connective tissue disease An autoimmune disease of skin and connective tissue that is characterized by blisters filled with a watery fluid, located_in skin. The disease is associated with the amount of gluten ingested. http://purl.obolibrary.org/obo/DOID_8504 impetigo http://purl.obolibrary.org/obo/DOID_4223 pyoderma A pyoderma consisting of three forms of skin lesions having either a thick, adherent, recurrent, dirty yellow crust with an erythematous margin (common or superficial impetigo) or lessions which are superficial, thin-walled, and bullous as found in bullous impetigo. The lesions in bullous (staphylococcal) impetigo, which are always caused by S aureus, are superficial, thin-walled, and bullous. http://purl.obolibrary.org/obo/DOID_8515 Cor pulmonale http://purl.obolibrary.org/obo/DOID_6000 congestive heart failure A congestive heart failure that involves a failure of the right side of the heart and is characterized by an enlargement of the right ventricle of the heart as a response to increased resistance or high blood pressure in the lungs. http://purl.obolibrary.org/obo/DOID_854 collagen disease http://purl.obolibrary.org/obo/DOID_65 connective tissue disease A connective tissue disease that characterized by connective tissue disease that has_material_basis in inheritable defects in collagen. http://purl.obolibrary.org/obo/DOID_8552 chronic myeloid leukemia http://purl.obolibrary.org/obo/DOID_8692 myeloid leukemia A myeloid leukemia that is characterized by over production of white blood cells. http://purl.obolibrary.org/obo/DOID_8618 oral cavity cancer http://purl.obolibrary.org/obo/DOID_403 mouth disease A gastrointestinal system cancer that is located_in the oral cavity. http://purl.obolibrary.org/obo/DOID_8619 recurrent hypersomnia http://purl.obolibrary.org/obo/DOID_535 sleep disorder A sleep disorder that involves recurring bouts of excessive amounts of sleepiness. http://purl.obolibrary.org/obo/DOID_863 nervous system disease http://purl.obolibrary.org/obo/DOID_7 disease of anatomical entity A disease of anatomical entity that is located_in the central nervous system or located_in the peripheral nervous system. http://purl.obolibrary.org/obo/DOID_865 vasculitis http://purl.obolibrary.org/obo/DOID_178 vascular disease A vascular disease that is characterized by inflammation of the blood vessels. http://purl.obolibrary.org/obo/DOID_866 vein disease http://purl.obolibrary.org/obo/DOID_178 vascular disease A vascular disease that is located_in a vein. http://purl.obolibrary.org/obo/DOID_8670 eating disorder http://purl.obolibrary.org/obo/DOID_0060038 specific developmental disorder A specific developmental disorder that is characterized by abnormal eating habits that may involve either insufficient or excessive food intake to the detriment of an individual's physical and emotional health. http://purl.obolibrary.org/obo/DOID_869 cholesteatoma http://purl.obolibrary.org/obo/DOID_161 keratosis A keratosis that is characterized by keratinizing squamous epithelium located in middle ear and/or mastoid, subepithelial connective tissue and by the progressive accumulation of keratin debris with or without surrounding inflammatory reaction. http://purl.obolibrary.org/obo/DOID_870 neuropathy http://purl.obolibrary.org/obo/DOID_574 peripheral nervous system disease A nervous system disease that is located_in nerves or nerve cells. http://purl.obolibrary.org/obo/DOID_8719 in situ carcinoma http://purl.obolibrary.org/obo/DOID_0060071 pre-malignant neoplasm A carcinoma that is an early development defined by the absence of invasion of surrounding tissues. http://purl.obolibrary.org/obo/DOID_8736 smallpox http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results in infection located in skin, has_material_basis_in Variola virus, which is transmitted by droplets from oral, nasal or pharyngeal mucosa, transmitted by contact with the body fluids, or transmitted by fomites. The infection results in formation of lesions, first on the face, hands and forearms and later on the trunk. http://purl.obolibrary.org/obo/DOID_874 bacterial pneumonia http://purl.obolibrary.org/obo/DOID_552 pneumonia A pneumonia involving inflammation of the lungs caused by bacteria. http://purl.obolibrary.org/obo/DOID_8778 Crohn's disease http://purl.obolibrary.org/obo/DOID_0050589 inflammatory bowel disease An intestinal disease that involves inflammation located_in intestine. http://purl.obolibrary.org/obo/DOID_8791 breast carcinoma in situ http://purl.obolibrary.org/obo/DOID_8719 in situ carcinoma An in situ carcinoma that is located_in the breast. http://purl.obolibrary.org/obo/DOID_883 parasitic helminthiasis infectious disease http://purl.obolibrary.org/obo/DOID_1398 parasitic infectious disease A parasitic infectious disease that occurs when part of the body is infested with parasitic worms such as cestodes, nematodes and trematodes. http://purl.obolibrary.org/obo/DOID_8850 salivary gland cancer http://purl.obolibrary.org/obo/DOID_8618 oral cavity cancer An oral cavity cancer that is located_in the salivary gland. http://purl.obolibrary.org/obo/DOID_8857 lupus erythematosus http://purl.obolibrary.org/obo/DOID_0060032 autoimmune disease of musculoskeletal system An autoimmune disease that is characterized by a constellation of findings that include elevated antibodies to nuclear antigens, antiphospholipids, low complement levels, ulcers, non-scarring alopecia, renal or neurologic damage, and low white blood cell and platelet counts, has_symptom rashes, fatigue, arthritis, hair loss, seizures, and symptoms related to affected organs. http://purl.obolibrary.org/obo/DOID_8864 acute monocytic leukemia http://purl.obolibrary.org/obo/DOID_8527 monocytic leukemia A monocytic leukemia where the majority of monocytic cells are promonocytes. http://purl.obolibrary.org/obo/DOID_8913 dermatophytosis http://purl.obolibrary.org/obo/DOID_0050134 cutaneous mycosis A cutaneous mycosis that results_in fungal infection located_in scalp, located_in glabrous skin, or located_in nail, has_material_basis_in Ascomycota fungi that belong to a group called dermatophytes, which have the ability to utilize keratin as a nutrient source. http://purl.obolibrary.org/obo/DOID_8923 skin melanoma http://purl.obolibrary.org/obo/DOID_4159 skin cancer A skin cancer that has_material_basis_in melanocytes. http://purl.obolibrary.org/obo/DOID_8927 learning disability http://purl.obolibrary.org/obo/DOID_0060038 specific developmental disorder A specific developmental disorder that involves difficulty in scholastic skills such as reading, writing, spelling, reasoning, recalling and/or organizing information resulting from the brain's inability to receive and process information. http://purl.obolibrary.org/obo/DOID_8955 sideroblastic anemia http://purl.obolibrary.org/obo/DOID_12449 aplastic anemia An aplastic anemia where the bone marrow produces ringed sideroblasts rather than healthy red blood cells (erythrocytes). http://purl.obolibrary.org/obo/DOID_896 metal metabolism disorder http://purl.obolibrary.org/obo/DOID_655 inherited metabolic disorder An inherited metabolic disorder that involves metabolic disturbances in the processing or distribution of dietary minerals. http://purl.obolibrary.org/obo/DOID_898 autosomal dominant polycystic kidney disease http://purl.obolibrary.org/obo/DOID_0080322 polycystic kidney disease A polycystic kidney disease characterized by the presence of multiple cysts located_in the kidney resulting from ciliopathy that disrupts the function of primary cilium, inherited in an autosomal dominant fashion. http://purl.obolibrary.org/obo/DOID_9036 parotid gland cancer http://purl.obolibrary.org/obo/DOID_8850 salivary gland cancer A salivary gland cancer that is located_in the parotid gland. http://purl.obolibrary.org/obo/DOID_906 peroxisomal disease http://purl.obolibrary.org/obo/DOID_655 inherited metabolic disorder An inherited metabolic disorder that involves peroxisome malfunction. http://purl.obolibrary.org/obo/DOID_9113 granuloma inguinale http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease A primary bacterial infectious disease that results_in infection located_in skin or located_in mucosa of genital tract, has_material_basis_in Klebsiella granulomatis, transmitted by sexual contact or transmitted_by contact with the open sores. The infection has_symptom painless genital ulcers. http://purl.obolibrary.org/obo/DOID_9119 acute myeloid leukemia http://purl.obolibrary.org/obo/DOID_8692 myeloid leukemia A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. http://purl.obolibrary.org/obo/DOID_9120 amyloidosis http://purl.obolibrary.org/obo/DOID_0060158 acquired metabolic disease An acquired metabolic disease that has_material_basis_in extracellular tissue deposition of mis-folded proteins called fibrils composed of low molecular weight subunits of a variety of proteins. These deposits may result in a wide range of clinical manifestations depending upon their type, location, and the amount of deposition. http://purl.obolibrary.org/obo/DOID_9182 pemphigus http://purl.obolibrary.org/obo/DOID_8502 bullous skin disease A bullous skin disease that is characterized by blistering of the skin and mucous membranes (mouth, nose, throat, eyes, and genitals). http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder http://purl.obolibrary.org/obo/DOID_655 inherited metabolic disorder An inherited metabolic disorder that is characterized by impaired synthesis and degradation of amino acids. http://purl.obolibrary.org/obo/DOID_9256 colorectal cancer http://purl.obolibrary.org/obo/DOID_5672 large intestine cancer A large intestine cancer that is located_in the colon and/or located_in the rectum. http://purl.obolibrary.org/obo/DOID_9265 histidine metabolism disease http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder An amino acid metabolic disorder that involves deficiency in histidine. http://purl.obolibrary.org/obo/DOID_9275 tyrosinemia http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder An amino acid metabolic disorder that involves impaired break down of the amino acid tyrosine. http://purl.obolibrary.org/obo/DOID_9297 lip disease http://purl.obolibrary.org/obo/DOID_403 mouth disease A mouth disease located_in the lip. http://purl.obolibrary.org/obo/DOID_93 language disorder http://purl.obolibrary.org/obo/DOID_2033 communication disorder A communication disorder that involves the processing of linguistic information. http://purl.obolibrary.org/obo/DOID_930 orbital disease http://purl.obolibrary.org/obo/DOID_0080001 bone disease An adnexa disease that is located_in the eye socket. http://purl.obolibrary.org/obo/DOID_934 viral infectious disease http://purl.obolibrary.org/obo/DOID_0050117 disease by infectious agent A disease by infectious agent that results in infection, has_material_basis_in Viruses. http://purl.obolibrary.org/obo/DOID_9351 diabetes mellitus http://purl.obolibrary.org/obo/DOID_4194 glucose metabolism disease A glucose metabolism disease characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. http://purl.obolibrary.org/obo/DOID_9352 type 2 diabetes mellitus http://purl.obolibrary.org/obo/DOID_9351 diabetes mellitus A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. http://purl.obolibrary.org/obo/DOID_936 brain disease http://purl.obolibrary.org/obo/DOID_331 central nervous system disease A central nervous system disease that is located_in the brain. http://purl.obolibrary.org/obo/DOID_9406 hypopituitarism http://purl.obolibrary.org/obo/DOID_53 pituitary gland disease A pituitary gland disease characterized by the decreased secretion of one or more of the eight hormones normally produced by the pituitary gland. http://purl.obolibrary.org/obo/DOID_9423 blepharitis http://purl.obolibrary.org/obo/DOID_530 eyelid disease An eyelid disease that is characterized by often chronic inflammation of the eyelid, generally the part where eyelashes grow. http://purl.obolibrary.org/obo/DOID_9428 intracranial hypertension http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is characterized by high pressure inside the skull, the brain tissue and cerebrospinal fluid, has_symptom headache, has_symptom vomiting, has_symptom altered mental status, has_symptom papilledema. http://purl.obolibrary.org/obo/DOID_9446 cholangitis http://purl.obolibrary.org/obo/DOID_4138 bile duct disease A bile duct disease that is an inflammation of the bile duct. http://purl.obolibrary.org/obo/DOID_9455 lipid storage disease http://purl.obolibrary.org/obo/DOID_3211 lysosomal storage disease A lysosomal storage disease that involves the accumulation of harmful amounts of lipids (fats) in some of the body's cells and tissues. http://purl.obolibrary.org/obo/DOID_9460 uterine corpus cancer http://purl.obolibrary.org/obo/DOID_363 uterine cancer A uterine cancer that is located_in the uterine corpus. http://purl.obolibrary.org/obo/DOID_9463 otitis externa http://purl.obolibrary.org/obo/DOID_379 external ear disease An external ear disease that involves inflammation of the outer ear and ear canal. It can be caused by active bacterial or fungal infections. http://purl.obolibrary.org/obo/DOID_9471 meningitis http://purl.obolibrary.org/obo/DOID_331 central nervous system disease A central nervous system disease that is characterized by an inflammation of the pia-arachnoid meninges. It can be caused by growth of bacteria, fungi, or parasites within the subarachnoid space or by the growth of bacteria or viruses within the meningeal or ependymal cells. http://purl.obolibrary.org/obo/DOID_9500 leukocyte disease http://purl.obolibrary.org/obo/DOID_74 hematopoietic system disease A hematopoietic system disease that is located_in white blood cells. http://purl.obolibrary.org/obo/DOID_9553 adrenal gland disease http://purl.obolibrary.org/obo/DOID_28 endocrine system disease An endocrine system disease that is located_in the adrenal gland. http://purl.obolibrary.org/obo/DOID_9562 primary ciliary dyskinesia http://purl.obolibrary.org/obo/DOID_0060340 ciliopathy A ciliopathy that is characterized by impaired function of the cilia lining the respiratory tract (lower and upper, sinuses, Eustachian tube, middle ear) and fallopian tube. http://purl.obolibrary.org/obo/DOID_9588 encephalitis http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is characterized as an acute inflammation of the brain with flu-like symptoms. http://purl.obolibrary.org/obo/DOID_963 episodic ataxia http://purl.obolibrary.org/obo/DOID_0050951 hereditary ataxia A hereditary ataxia characterized by sporadic bouts of ataxia with or without continuous muscle movement. http://purl.obolibrary.org/obo/DOID_9637 stomatitis http://purl.obolibrary.org/obo/DOID_9297 lip disease A mouth disease that is characterized by inflammation of the mouth and lips. http://purl.obolibrary.org/obo/DOID_9669 senile cataract http://purl.obolibrary.org/obo/DOID_83 cataract A cataract that is characterized by thickening and loss of transparency of the lens with age progression, caused by a multifactorial etiology related to aging. http://purl.obolibrary.org/obo/DOID_9720 vitreous disease http://purl.obolibrary.org/obo/DOID_5614 eye disease An eye and adnexa disease that is located in the vitreous of the eye. http://purl.obolibrary.org/obo/DOID_9739 eustachian tube disease http://purl.obolibrary.org/obo/DOID_11180 non-suppurative otitis media A non-suppurative otitis media and eustachian tube disorder in which the tube is either too narrow or too wide. It can also be cuased by nasal inflammation which leads to inflammatory swelling and obstruction of the eustachian tube, which, in turn, leads to increased negative pressure in the middle ear and improper ventilation. http://purl.obolibrary.org/obo/DOID_974 upper respiratory tract disease http://purl.obolibrary.org/obo/DOID_1579 respiratory system disease A respiratory system disease which involves the upper respiratory tract. http://purl.obolibrary.org/obo/DOID_9742 pelvic varices http://purl.obolibrary.org/obo/DOID_799 varicose veins A varicose veins that is located_in the pelvis. http://purl.obolibrary.org/obo/DOID_9809 hypersensitivity vasculitis http://purl.obolibrary.org/obo/DOID_1557 hypersensitivity reaction type III disease A hypersensitivity reaction type III disease that is characterized by inflammation and injury to blood vessels and has_symptom purpura, telangiectasia, blistering, urticaria, and ulcers. http://purl.obolibrary.org/obo/DOID_9840 esotropia http://purl.obolibrary.org/obo/DOID_540 strabismus A strabismus that is characterized the eye which turns inward toward the nose. http://purl.obolibrary.org/obo/DOID_9849 Meniere's disease http://purl.obolibrary.org/obo/DOID_9848 endolymphatic hydrops A vestibular disease characterized by vertigo, low-pitched tinnitus and hearing loss. http://purl.obolibrary.org/obo/DOID_986 alopecia areata http://purl.obolibrary.org/obo/DOID_0060039 autoimmune disease of skin and connective tissue An autoimmune disease resulting in the loss of hair on the scalp and elsewhere on the body initially causing bald spots. http://purl.obolibrary.org/obo/DOID_987 alopecia http://purl.obolibrary.org/obo/DOID_4535 hypotrichosis A hypotrichosis that is characterized by a loss of hair from the head or body. http://purl.obolibrary.org/obo/DOID_9870 galactosemia http://purl.obolibrary.org/obo/DOID_2978 carbohydrate metabolic disorder A carbohydrate metabolic disorder that involves a defect in galactose metabolism resulting in toxic levels of galactose 1-phosphate in various tissues. http://purl.obolibrary.org/obo/DOID_9884 muscular dystrophy http://purl.obolibrary.org/obo/DOID_423 myopathy A myopathy is characterized by progressive skeletal muscle weakness degeneration. http://purl.obolibrary.org/obo/DOID_9938 dacryocystitis http://purl.obolibrary.org/obo/DOID_6970 acute inflammation of lacrimal passage An acute inflammation of lacrimal passage that is characterized by inflammation of the lacrimal sac, has_symptom conjunctivitis and has_symptom purulent discharge. http://purl.obolibrary.org/obo/DOID_9952 acute lymphoblastic leukemia http://purl.obolibrary.org/obo/DOID_12603 acute leukemia A acute leukemia that is characterized by over production of lymphoblasts. http://purl.obolibrary.org/obo/DOID_9965 toxoplasmosis http://purl.obolibrary.org/obo/DOID_2113 coccidiosis A coccidiosis that has_material_basis_in protozoan Toxoplasma gondii. The parasite effects most genera of warm-blooded animals, including humans, but the primary host is the felid (cat) family. Animals are infected by eating infected meat, by ingestion of feces of a cat that has itself recently been infected, or transmission_by mother to fetus. The symptoms include bilateral, nontender cervical or axillary lymphadenopathy, fever, malaise, myalgia, hepatosplenomegaly, anemia and leukopenia. http://purl.obolibrary.org/obo/DOID_9970 obesity http://purl.obolibrary.org/obo/DOID_654 overnutrition An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. http://purl.obolibrary.org/obo/DOID_9973 substance dependence http://purl.obolibrary.org/obo/DOID_303 substance-related disorder A substance-related disorder that involves the continued use of alcohol or other drugs despite problems related to use of the substance. http://purl.obolibrary.org/obo/DOID_9988 tertiary neurosyphilis http://purl.obolibrary.org/obo/DOID_936 brain disease A tertiary syphilis that results in infection located in brain or located in spinal cord. http://purl.obolibrary.org/obo/UBERON_0000056 ureter http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity Muscular duct that propels urine from the kidneys to the urinary bladder, or related organs. http://purl.obolibrary.org/obo/UBERON_0000160 intestine http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine. http://purl.obolibrary.org/obo/UBERON_0000178 blood http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity A fluid that is composed of blood plasma and erythrocytes. http://purl.obolibrary.org/obo/UBERON_0000945 stomach http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium. http://purl.obolibrary.org/obo/UBERON_0000955 brain http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]. http://purl.obolibrary.org/obo/UBERON_0000992 ovary http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity the gonad of a female organism which contains germ cells http://purl.obolibrary.org/obo/UBERON_0000995 uterus http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity the female muscular organ of gestation in which the developing embryo or fetus is nourished until birth http://purl.obolibrary.org/obo/UBERON_0000997 mammalian vulva http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity external genital organs of the female mammal[WP]. http://purl.obolibrary.org/obo/UBERON_0001016 nervous system http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]. http://purl.obolibrary.org/obo/UBERON_0001043 esophagus http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993). http://purl.obolibrary.org/obo/UBERON_0001255 urinary bladder http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity distensible musculomembranous organ situated in the anterior part of the pelvic cavity in which urine collects before excretion[MP]. http://purl.obolibrary.org/obo/UBERON_0002046 thyroid gland http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity A two-lobed endocrine gland found in all vertebrates, located in front of and on either side of the trachea in humans, and producing various hormones, such as triiodothyronine and calcitonin[BTO]. http://purl.obolibrary.org/obo/UBERON_0002048 lung http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity Respiration organ that develops as an outpocketing of the esophagus. http://purl.obolibrary.org/obo/UBERON_0002107 liver http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]. http://purl.obolibrary.org/obo/UBERON_0002110 gall bladder http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity An organ that aids digestion and stores bile produced by the liver[WP]. http://purl.obolibrary.org/obo/UBERON_0002113 kidney http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity A paired organ of the urinary tract which has the production of urine as its primary function. http://purl.obolibrary.org/obo/UBERON_0002114 duodenum http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one). http://purl.obolibrary.org/obo/UBERON_0002367 prostate gland http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid. http://purl.obolibrary.org/obo/UBERON_0002391 lymph http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity Lymph is the fluid that is formed when interstitial fluid enters the conduits of the lymphatic system through lymph capillaries[WP]. http://purl.obolibrary.org/obo/DOID_0080544 hyper IgM syndrome http://purl.obolibrary.org/obo/DOID_2959 hyperimmunoglobulin syndrome A hyperimmunoglobin syndrome that is characterized by an immune system that fails to produce normal levels of the antibodies IgA, IgG and IgE but can produce normal or elevated levels of IgM. http://purl.obolibrary.org/obo/DOID_0080545 hyper IgE syndrome http://purl.obolibrary.org/obo/DOID_2959 hyperimmunoglobulin syndrome A hyperimmunoglobulin syndrome that is characterized by eczema, distinct facial features, a tendency to experience bone fractures and recurrent bacterial infections of the skin and lungs. http://purl.obolibrary.org/obo/DOID_0111417 familial chylomicronemia syndrome http://purl.obolibrary.org/obo/DOID_1168 familial hyperlipidemia A familial hyperlipidemia characterized by hypertriglyceridemia and fasting chylomicronemia. http://purl.obolibrary.org/obo/GO_0008144 drug binding http://purl.obolibrary.org/obo/GO_0005488 binding Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease. http://purl.obolibrary.org/obo/GO_0051327 meiotic M phase http://purl.obolibrary.org/obo/GO_0000279 M phase A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a meiotic cell cycle. http://purl.obolibrary.org/obo/GO_0051330 meiotic G1 phase http://purl.obolibrary.org/obo/GO_0051318 G1 phase The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by meiosis and the beginning of DNA synthesis. http://purl.obolibrary.org/obo/GO_0051331 meiotic G2 phase http://purl.obolibrary.org/obo/GO_0051319 G2 phase The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by meiosis. http://purl.obolibrary.org/obo/GO_0051332 meiotic S phase http://purl.obolibrary.org/obo/GO_0051320 S phase The cell cycle phase, following G1, during which DNA synthesis takes place as part of a meiotic cell cycle. http://purl.obolibrary.org/obo/UBERON_0000068 embryo stage http://purl.obolibrary.org/obo/UBERON_0000105 life cycle stage A life cycle stage that starts with fertilization and ends with the fully formed embryo. http://purl.obolibrary.org/obo/UBERON_0000105 life cycle stage http://purl.obolibrary.org/obo/PATO_0000011 age A spatiotemporal region encompassing some part of the life cycle of an organism. http://purl.obolibrary.org/obo/UBERON_0000109 gastrula stage http://purl.obolibrary.org/obo/UBERON_0000105 life cycle stage A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. http://purl.obolibrary.org/obo/UBERON_0000113 post-juvenile adult stage http://purl.obolibrary.org/obo/UBERON_0000105 life cycle stage The stage of being a sexually mature adult animal. http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity http://www.bioassayontology.org/bao#BAO_0003114 assay biology component Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. http://purl.obolibrary.org/obo/UBERON_0001474 bone element http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity Skeletal element that is composed of bone tissue. http://purl.obolibrary.org/obo/UBERON_0001969 blood plasma http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity The liquid component of blood, in which erythrocytes are suspended. http://purl.obolibrary.org/obo/UBERON_0001977 blood serum http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity The portion of blood plasma that excludes clotting factors. http://purl.obolibrary.org/obo/UBERON_0002097 skin of body http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity The organ covering the body that consists of the dermis and epidermis. http://purl.obolibrary.org/obo/UBERON_0007811 craniocervical region http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae. http://purl.obolibrary.org/obo/CLO_0037217 DRD cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 DRD=BJ fibroblasts expressing hTERT, SV40 small T oncoprotein, dominant negative p53, cyclin D1, a mutant form of CDK4, along with the oncogene HRASV12 http://purl.obolibrary.org/obo/CLO_0037218 HL2/3 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 HL2/3 is a derivative of HeLa cells and contains a stably integrated copies of the HIV-1 molecular clone HXB2/3gpt. http://purl.obolibrary.org/obo/CLO_0037219 HeLa-MAGI-CCR5 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 HeLa-MAGI-CCR5 cells are derived from HeLa cells and express human CD4, CXCR4 and CCR5, and an integrated gene encoding the b-galactosidase gene expressed from the HIV long terminal repeat. http://purl.obolibrary.org/obo/CLO_0037220 HeLa-R5-16 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 HeLa-R5-16 (gift from Roche Palo Alto, LLC) is a derivative of HeLa cells, engineered to express the Envelope protein (Env) from the CCR5-tropic HIV-1 clinical isolate 92US715, and also to express the Tat protein from HIV-1 NL43 http://purl.obolibrary.org/obo/CLO_0037222 Sufu-KO-LIGHT cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 Sufu-KO-LIGHT cells were derived from Sufu knockout mouse embryonic fibroblasts according to the method of Chen et al. [Genes Dev. 2009;23(16): 1910-28.] The cells were co-transfected with the zeocin resistance vector (pVgRXR, Invitrogen) and a firefly luciferase reporter driven by eight Gli binding sites and a γ-crystallin basal promoter (8XGHBS-FL). Sufu-KO-LIGHT lacks Sufu and exhibits constitutive Hh target gene expression in response to endogenous Gli activators. http://purl.obolibrary.org/obo/CLO_0037223 Ub-G76V-GFP/HeLa http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 A Hela-derived cell line cell that expresses ubiquitinated GFP (Green Fluroescent Protein) http://purl.obolibrary.org/obo/UO_0000190 ratio http://purl.obolibrary.org/obo/UO_0000186 dimensionless unit A dimensionless unit which denotes an amount or magnitude of one quantity relative to another. http://purl.obolibrary.org/obo/UO_0000020 picometer http://purl.obolibrary.org/obo/UO_0000001 length unit A length unit which is equal to 10^[-12] m. http://purl.obolibrary.org/obo/UO_0000030 picosecond http://purl.obolibrary.org/obo/UO_0000003 time unit A time unit which is equal to 10^[-12] s. http://purl.obolibrary.org/obo/UO_0000150 nanosecond http://purl.obolibrary.org/obo/UO_0000003 time unit A time unit which is equal to one thousandth of one millionth of a second or 10^[-9] s. http://purl.obolibrary.org/obo/UO_0000151 century http://purl.obolibrary.org/obo/UO_0000003 time unit A time unit which is equal to 100 years. http://purl.obolibrary.org/obo/UO_0000152 half life http://purl.obolibrary.org/obo/UO_0000003 time unit A time unit which represents the period over which the activity or concentration of a specified chemical or element falls to half its original activity or concentration. http://www.bioassayontology.org/bao#BAO_0000513 96 well plate http://www.bioassayontology.org/bao#BAO_0000508 microplate This microplate contains 96 wells. It is suitable for a low throughput assay. http://www.bioassayontology.org/bao#BAO_0000515 384 well plate http://www.bioassayontology.org/bao#BAO_0000508 microplate This microplate contains 384 wells. It is suitable for a HTS assay. http://www.bioassayontology.org/bao#BAO_0001005 rauwolscine http://www.bioassayontology.org/bao#BAO_0003043 molecular entity Rauwolscine acts predominantly as a α2-adrenergic receptor antagonist. It has also been shown to function as a 5-HT1A receptor partial agonist and 5-HT2A and 5-HT2B receptor antagonist. http://www.bioassayontology.org/bao#BAO_0000464 densitometric scan http://www.bioassayontology.org/bao#BAO_0000468 signal quantitation method Following a western analysis, the individual proteins in a gel, blot, or autoradiogram are quantitated by a densitometric scan over a limited range of protein concentration per band (1-10 ug). A scanner measures the optical density of the material by directing a beam of light and measuring its transmission or reflection. http://purl.obolibrary.org/obo/DOID_0080217 lysosomal and lipase deficiency http://purl.obolibrary.org/obo/DOID_9455 lipid storage disease A lipid storage disease characterized by lysosomal and lipase deficiency. http://purl.obolibrary.org/obo/DOID_60001 pulmonary artery disease http://purl.obolibrary.org/obo/DOID_850 lung disease An artery disease that is located in the lungs. http://purl.obolibrary.org/obo/DOID_0080524 thyroid gland adenocarcinoma http://purl.obolibrary.org/obo/DOID_3963 thyroid gland carcinoma A thyroid gland carcinoma that derives_from epithelial cells of glandular origin. http://purl.obolibrary.org/obo/DOID_0111229 congenital muscular dystrophy-dystroglycanopathy type A http://purl.obolibrary.org/obo/DOID_0050588 muscular dystrophy-dystroglycanopathy A congenital muscular dystrophy-dystroglycanopathy type A characterized by cobblestone lissencephaly, muscle weakness, and brain and eye anomalies that has_material_basis_in autosomal recessive inheritance a defect in alpha-dystroglycan post-translational processing. http://purl.obolibrary.org/obo/DOID_0111824 Aarskog syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by facial, limbs and genital anomalies, and a disproportionate acromelic short stature. http://www.bioassayontology.org/bao#BAO_0000448 morphology assessment method http://www.bioassayontology.org/bao#BAO_0002202 assay design method The technologies used to measure the size and shape of cells and organelles (phenotype). These are detected by microscopy. http://www.bioassayontology.org/bao#BAO_0000579 saturation binding http://www.bioassayontology.org/bao#BAO_0000476 ligand binding mode of action These experiments measure specific radioligand binding at equilibrium at various concentrations of the radioligand. http://www.bioassayontology.org/bao#BAO_0002772 AUC(iv) http://www.bioassayontology.org/bao#BAO_0002120 AUC The area under the drug concentration-time curve following an intravenous dose. http://www.bioassayontology.org/bao#BAO_0001051 WKYMVm peptide http://www.bioassayontology.org/bao#BAO_0000325 peptide Selective agonist for the formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM) and FPR3 (EC50 = 3 nM), expressed on immune cells. Trp-Lys-Tyr-Met-Val-D-Med-NH2 http://www.bioassayontology.org/bao#BAO_0000163 electrical sensor http://www.bioassayontology.org/bao#BAO_0000427 label free method Electrical sensors are used to measure the electrical impedance, or the current-voltage relationships of these ion channels. http://www.bioassayontology.org/bao#BAO_0000264 biological process http://www.bioassayontology.org/bao#BAO_0003114 assay biology component Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end (from GO). http://www.bioassayontology.org/bao#BAO_0003022 foreign promoter region http://www.bioassayontology.org/bao#BAO_0003019 regulatory region The regulatory DNA from a non-native gene, e.g., the regulatory region from the actin gene being cloned upstream of the myosin gene in a DNA construct. http://www.bioassayontology.org/bao#BAO_0002305 quantitative structure activity relationship analysis http://www.bioassayontology.org/bao#BAO_0002410 structure activity relationship analysis Mathematical relationships linking chemical structure and pharmacological activity in a quantitative manner for a series of compounds. Methods which can be used in QSAR include various regression and pattern recognition techniques. http://www.bioassayontology.org/bao#BAO_0000034 Kd http://www.bioassayontology.org/bao#BAO_0000587 binding constant Kd – is the equilibrium dissociation constant for a drug. It describes the affinity between a ligand (L) (such as a drug) and a protein (P). Ligand-protein affinities are influenced by non-covalent intermolecular interactions between the two molecules such as hydrogen bonding, electrostatic interactions, hydrophobic and Van der Waals forces. Kd = ([P] [L]) / [PL] The dissociation constant has molar units (M), which corresponds to the concentration of ligand [L] at which the binding site on a particular protein is half occupied, i.e. the concentration of ligand, at which the concentration of protein with ligand bound [PL], equals the concentration of protein with no ligand bound [P]. The smaller the dissociation constant, the more tightly bound the ligand is, or the higher the affinity between ligand and protein. http://www.graphpad.com/curvefit/law_of_mass_action.htm http://www.bioassayontology.org/bao#BAO_0000364 bacterium http://www.bioassayontology.org/bao#BAO_0000658 cellular organisms Bacteria lack membrane bound organelles and are surrounded by a rigid cell wall. Though they are unicellular, they function by aggregating into multicellular colonies. http://www.bioassayontology.org/bao#BAO_0000511 invertebrate http://www.bioassayontology.org/bao#BAO_0000659 metazoa These animals lack a vertebral column and many of which are used as model organisms in HTS screening including Drosophila, C.elegans, sea urchin, etc. http://www.bioassayontology.org/bao#BAO_0000362 mammalian http://www.bioassayontology.org/bao#BAO_0000510 vertebrate This includes animal models typically used in drug discovery for toxicity or pharmacology studies, such as mouse, rat (mammals). http://www.bioassayontology.org/bao#BAO_0000518 non-mammalian http://www.bioassayontology.org/bao#BAO_0000510 vertebrate This includes vertebrate model organisms such as the Danio rerio (zebrafish), Xenopus laevis, etc which are tested generally to understand development. http://www.bioassayontology.org/bao#BAO_0000232 virus http://www.bioassayontology.org/bao#BAO_0000551 organism Viruses are small infectious agents that depend on the host cells to reproduce. Outside the host, they contain a protein coat called capsid that encloses their genetic material (either DNA or RNA). Viruses can infect bacteria, plants and animals and cause a number of diseases, e.g. smallpox, chickenpox, influenza, polio, rabies, etc. http://www.bioassayontology.org/bao#BAO_0000605 plant http://www.bioassayontology.org/bao#BAO_0000509 eukaryote They are living organisms which derive their energy from photosynthesis, with the exception of parasitic plants. Plants include herbs, shrubs, trees, grasses, vines, etc. http://www.bioassayontology.org/bao#BAO_0000233 unicellular fungi http://www.bioassayontology.org/bao#BAO_0000418 fungi It includes the baker's yeast (Saccharomyces cerevisiae) and fission yeast (Schizosaccharomyces pombe), which are unicellular. http://www.bioassayontology.org/bao#BAO_0002440 gene knockdown by morpholino treatment http://www.bioassayontology.org/bao#BAO_0002433 gene knockdown Method for reducing gene expression using morpholinos. Morpholino oligomers are an antisense technology used to block access of other molecules to specific sequences within nucleic acid. Morpholinos block small (~25 base) regions of the base-pairing surfaces of ribonucleic acid (RNA). http://www.bioassayontology.org/bao#BAO_0000871 burnham center for chemical genomics http://www.bioassayontology.org/bao#BAO_0000709 research institute It is an MLPCN comprehensive screening center. http://www.bioassayontology.org/bao#BAO_0002473 SYBR Green I DNA staining http://www.bioassayontology.org/bao#BAO_0002472 fluorescent DNA intercalation method A technique for DNA detection using SYBR Green 1 stain.The fluorescence intensity of SYBR Green is enhanced over 100-fold on binding to DNA which results in bright fluorescent DNA bands against a very dark background. Using a Dark Reader transilluminator, it is possible to detect less than 100 pg of SYBR Green-stained DNA by eye and tens of picograms using a CCD system. http://www.bioassayontology.org/bao#BAO_0000375 fold activation http://www.bioassayontology.org/bao#BAO_0000193 fold change The ratio of biological activity in the presence of an exogenous substance to that in its absence. This result type is used exclusively with single point (screening concentration) assays. http://www.bioassayontology.org/bao#BAO_0002233 global sequence alignment http://www.bioassayontology.org/bao#BAO_0002232 sequence alignment by method Global alignments, which attempt to align every residue in every sequence, are most useful when the sequences in the query set are similar and of roughly equal size. http://www.bioassayontology.org/bao#BAO_0000288 isomerase http://www.bioassayontology.org/bao#BAO_0000279 enzyme Intramolecule rearrangement, i.e. isomerization changes within a single molecule. http://www.bioassayontology.org/bao#BAO_0000293 generic transferase http://www.bioassayontology.org/bao#BAO_0000292 transferase Includes all transferases except kinases. http://www.bioassayontology.org/bao#BAO_0002560 glycosylated http://www.bioassayontology.org/bao#BAO_0000672 posttranslationally modified A quality of an amino acid residue that has a carbohydrate moiety attached to it. http://www.bioassayontology.org/bao#BAO_0000133 oligonucleotide array http://www.bioassayontology.org/bao#BAO_0000504 nucleic acid array Oligonucleotides are immobilized by spotting on a solid support, such as a glass slide. They are hybridized with labeled nucleic acids from a sample and the signals measured, which reflects the composition of the sample nucleic acids. This is performed to either quantify gene expression or genomic profiling to understand genetic variation in humans. http://www.bioassayontology.org/bao#BAO_0002420 fluorescence-linked immunosorbent assay http://www.bioassayontology.org/bao#BAO_0000134 ELISA Fluorescence-linked immunosorbent assay (FLISA) is a technique where a fluorescent probe is used on an antibody of interest, which results in direct detecting fluorescence intensity instead of more complicated enzymatic reaction. Compared with the sandwich ELISA, FLISA has similar sensitivity and specificity, but it is much more rapid, economic and convenient. http://www.bioassayontology.org/bao#BAO_0000193 fold change http://www.bioassayontology.org/bao#BAO_0000181 response endpoint It is the ratio of biological activity in the presence of an exogenous substance to that in its absence. The fold change is useful when comparing test compounds evaluated across multiple functional assays because varying levels of efficacy can be observed amongst the different or same reference agonists. http://www.bioassayontology.org/bao#BAO_0002973 morphometric parameter http://www.bioassayontology.org/bao#BAO_0002969 assay readout parameter morphometric parameter is an output of image analysis measuring a structure, a concept that encompasses size and shape of the subject (cells, organisms). http://www.bioassayontology.org/bao#BAO_0000294 kinase http://www.bioassayontology.org/bao#BAO_0000292 transferase A protein kinase is an enzyme that modifies other proteins by chemically adding phosphate groups to them. The substrate protein's activity, localization and overall function is modulated by the kinase reaction. http://www.bioassayontology.org/bao#BAO_0000535 multiple concentration http://www.bioassayontology.org/bao#BAO_0002177 concentration throughput Concentration-response (dose-response) screen in which each concentration is only measured once. This is equivalent to quantitative high-throughput screening (qHTS). http://www.bioassayontology.org/bao#BAO_0002272 de novo structure design http://www.bioassayontology.org/bao#BAO_0002269 structure generation The design of bioactive compounds by incremental construction of a ligand model within a model of the receptor or enzyme active site, the structure of which is known from X-ray or NMR data. http://www.bioassayontology.org/bao#BAO_0000479 koff http://www.bioassayontology.org/bao#BAO_0000487 enzyme kinetic constant The off-rate associated with the release of inhibitor from an enzyme-inhibitor complex. http://www.bioassayontology.org/bao#BAO_0002877 AC1000 absolute http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint The compound concentration at which the fitted curve passes activity threshold 1000. http://www.bioassayontology.org/bao#BAO_0000553 multicellular fungi http://www.bioassayontology.org/bao#BAO_0000418 fungi Most of the fungi are multicellular, e.g. molds, mushrooms, etc. They are made up of multicellular filaments known as hyphae. Several parasitic fungi exist, which infect animals and plants, e.g., Aspergillus flavus, Claviceps purpurea, Pneumocystis jirovecii, etc. http://www.bioassayontology.org/bao#BAO_0000843 AK295 peptide http://www.bioassayontology.org/bao#BAO_0000325 peptide selective calpain inhibitor AK295 http://www.bioassayontology.org/bao#BAO_0000125 reporter gene method http://www.bioassayontology.org/bao#BAO_0003024 gene expression detection method Inducible reporter technologies involve the use of a reporter gene to study the effect of perturbagens on gene expression. Some reporter genes can be easily detected, e.g. green fluorescence protein, and others function as selectable markers, e.g. antibiotic resistance. http://www.bioassayontology.org/bao#BAO_0040008 edge detection http://www.bioassayontology.org/bao#BAO_0040007 image segmentation Edge detection is the process to identify regions in a digital image where the image brightness changes sharply or the image has discontinuities. http://www.bioassayontology.org/bao#BAO_0000404 x ray crystallography http://www.bioassayontology.org/bao#BAO_0000427 label free method X-ray crystallography is used to analyze protein-small molecule interactions. This binding interaction is monitored by measuring the difference of diffraction between protein-compound binding complex and protein alone. With this technique, both the binding interaction and bound compounds can be detected, which allows pools of 5-100 compounds to be tested for binding. http://www.bioassayontology.org/bao#BAO_0000527 z factor http://www.bioassayontology.org/bao#BAO_0000028 assay quality assessment method It describes the assay dynamic range considering range and data variation: Z=1-{3x[StdDev(sample)+StdDev(negcontrol)]/[Avg(sample)-Avg(negcontrol)]} Not to be confused with z-score. http://www.bioassayontology.org/bao#BAO_0000672 posttranslationally modified http://www.bioassayontology.org/bao#BAO_0000013 primary structure A quality of an amino acid residue that has a moiety (e.g., phosphate, carbohydrate) attached to it after translation. http://purl.obolibrary.org/obo/DOID_60007 cerebrovascular benign neoplasm http://purl.obolibrary.org/obo/DOID_0060091 cardiovascular organ benign neoplasm A cardiovascular organ benign neoplasm that is located_in the cerebrovascular system. http://purl.obolibrary.org/obo/DOID_60008 parathyroid gland benign neoplasm http://purl.obolibrary.org/obo/DOID_11201 parathyroid gland disease An endocrine organ benign neoplasm that is located_in some parathyroid gland. http://purl.obolibrary.org/obo/DOID_60009 pituitary gland benign neoplasm http://purl.obolibrary.org/obo/DOID_53 pituitary gland disease A benign neoplasm located in the pituitary gland. http://purl.obolibrary.org/obo/GO_0000080 mitotic G1 phase http://purl.obolibrary.org/obo/GO_0051318 G1 phase The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis. http://purl.obolibrary.org/obo/GO_0000084 mitotic S phase http://purl.obolibrary.org/obo/GO_0051320 S phase The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle. http://purl.obolibrary.org/obo/GO_0000085 mitotic G2 phase http://purl.obolibrary.org/obo/GO_0051319 G2 phase The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis. http://purl.obolibrary.org/obo/GO_0000087 mitotic M phase http://purl.obolibrary.org/obo/GO_0000279 M phase A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle. http://purl.obolibrary.org/obo/GO_0000189 obsolete MAPK import into nucleus http://purl.obolibrary.org/obo/GO_0006606 protein import into nucleus OBSOLETE. The directed movement of a MAP kinase to the nucleus upon activation. http://purl.obolibrary.org/obo/GO_0000278 mitotic cell cycle http://purl.obolibrary.org/obo/GO_0007049 cell cycle Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. http://purl.obolibrary.org/obo/GO_0000279 M phase http://purl.obolibrary.org/obo/GO_0022403 cell cycle phase A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase. http://purl.obolibrary.org/obo/GO_0001588 dopamine neurotransmitter receptor activity, coupled via Gs http://purl.obolibrary.org/obo/GO_0023052 signaling Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity. http://purl.obolibrary.org/obo/GO_0005102 signaling receptor binding http://purl.obolibrary.org/obo/GO_0005515 protein binding Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. http://purl.obolibrary.org/obo/GO_0005515 protein binding http://purl.obolibrary.org/obo/GO_0005488 binding Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). http://purl.obolibrary.org/obo/GO_0006351 transcription, DNA-templated http://purl.obolibrary.org/obo/GO_0010467 gene expression The cellular synthesis of RNA on a template of DNA. http://purl.obolibrary.org/obo/GO_0006412 translation http://purl.obolibrary.org/obo/GO_0010467 gene expression The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. http://purl.obolibrary.org/obo/GO_0031175 neuron projection development http://purl.obolibrary.org/obo/GO_0048666 neuron development The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). http://purl.obolibrary.org/obo/GO_0051318 G1 phase http://purl.obolibrary.org/obo/GO_0022403 cell cycle phase The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis. http://purl.obolibrary.org/obo/GO_0051319 G2 phase http://purl.obolibrary.org/obo/GO_0022403 cell cycle phase The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis). http://purl.obolibrary.org/obo/GO_0051320 S phase http://purl.obolibrary.org/obo/GO_0022403 cell cycle phase The cell cycle phase, following G1, during which DNA synthesis takes place. http://purl.obolibrary.org/obo/GO_0051321 meiotic cell cycle http://purl.obolibrary.org/obo/GO_0007049 cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. http://purl.obolibrary.org/obo/GO_0031690 adrenergic receptor binding http://purl.obolibrary.org/obo/GO_0005102 signaling receptor binding Interacting selectively and non-covalently with an adrenergic receptor. http://purl.obolibrary.org/obo/GO_0031748 D1 dopamine receptor binding http://purl.obolibrary.org/obo/GO_0005102 signaling receptor binding Interacting selectively and non-covalently with a D1 dopamine receptor. http://purl.obolibrary.org/obo/GO_0031752 D5 dopamine receptor binding http://purl.obolibrary.org/obo/GO_0005102 signaling receptor binding Interacting selectively and non-covalently with a D5 dopamine receptor. http://purl.obolibrary.org/obo/GO_0042991 obsolete transcription factor import into nucleus http://purl.obolibrary.org/obo/GO_0006606 protein import into nucleus OBSOLETE. The directed movement of a transcription factor from the cytoplasm to the nucleus. http://purl.obolibrary.org/obo/UO_0000012 kelvin http://purl.obolibrary.org/obo/UO_0000005 temperature unit A thermodynamic temperature unit which is equal to the fraction 1/273.16 of the thermodynamic temperature of the triple point of water. http://purl.obolibrary.org/obo/UO_0000028 millisecond http://purl.obolibrary.org/obo/UO_0000003 time unit A time unit which is equal to one thousandth of a second or 10^[-3] s. http://purl.obolibrary.org/obo/UO_0000029 microsecond http://purl.obolibrary.org/obo/UO_0000003 time unit A time unit which is equal to one millionth of a second or 10^[-6] s. http://purl.obolibrary.org/obo/UO_0000061 unit of molarity http://purl.obolibrary.org/obo/UO_0000051 concentration unit A concentration unit which is a standard measure of the number of moles of a given substance per liter of solution. http://purl.obolibrary.org/obo/UO_0000186 dimensionless unit http://www.bioassayontology.org/bao#BAO_0000077 unit of measurement A unit which is a standard measure of physical quantity consisting of only a numerical number without any units. http://purl.obolibrary.org/obo/UO_0000187 percent http://purl.obolibrary.org/obo/UO_0000190 ratio A dimensionless ratio unit which denotes numbers as fractions of 100. http://purl.obolibrary.org/obo/UO_0000195 degree Fahrenheit http://purl.obolibrary.org/obo/UO_0000005 temperature unit A temperature unit which is equal to 5/9ths of a kelvin. Negative 40 degrees Fahrenheit is equal to negative 40 degrees Celsius. http://www.bioassayontology.org/bao#BAO_0000868 BRL-54443 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity 5-Hydroxy-3-(1-methylpiperidin-4-yl)-1H-indole A potent 5-ht1E/1F receptor agonist http://www.bioassayontology.org/bao#BAO_0000188 EC50 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint The effective concentration of an agonist, which produces 50% of the maximum possible response for that agonist. http://www.bioassayontology.org/bao#BAO_0002885 ECMax_Agonist http://www.bioassayontology.org/bao#BAO_0002883 ECMax The agonist concentration whereupon perceived activity reaches the maximum value observed (with a positive control). http://www.bioassayontology.org/bao#BAO_0002884 ECMax_Tm http://www.bioassayontology.org/bao#BAO_0002883 ECMax The compound concentration whereupon perceived activity (change in Tm) reaches the maximum value observed (with a positive control). http://www.bioassayontology.org/bao#BAO_0003065 viability indicator http://purl.obolibrary.org/obo/CHEBI_24432 biological role The role of a molecular entity of specifying the cell's status of being alive, e.g., ATP. http://purl.obolibrary.org/obo/DOID_0080810 acute asthma http://purl.obolibrary.org/obo/DOID_2841 asthma An asthma that is characterized by severe and sudden onset of increasing wheezing, airways closing, smooth muscle contraction, mucus plugging and lower airway edema that may be reversible upon treatment. http://purl.obolibrary.org/obo/GO_0045837 negative regulation of membrane potential http://purl.obolibrary.org/obo/GO_0042391 regulation of membrane potential Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. http://purl.obolibrary.org/obo/GO_0045838 positive regulation of membrane potential http://purl.obolibrary.org/obo/GO_0042391 regulation of membrane potential Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. http://purl.obolibrary.org/obo/GO_0051881 regulation of mitochondrial membrane potential http://purl.obolibrary.org/obo/GO_0042391 regulation of membrane potential Any process that modulates the establishment or extent of the mitochondrial membrane potential, the electric potential existing across the mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. http://www.bioassayontology.org/bao#BAO_0000401 filter assay http://www.bioassayontology.org/bao#BAO_0000405 scintillation counting This assay is performed to study interaction between a radio-labeled ligand and the receptor. The reaction mixture containing the receptor and radioligand is transferred to a filter plate, washed to remove the unbound radioligand. The bound complex remains on the filter, which can be eluted into the scintillation fluid and the radioactivity measured. Filter assays differ from SPA because a separation of free radioligand and radioligand bound to the receptor is required for measurement. http://www.bioassayontology.org/bao#BAO_0000222 generic hydrolase http://www.bioassayontology.org/bao#BAO_0000287 hydrolase Includes all hydrolases except phosphatases and proteases. http://www.bioassayontology.org/bao#BAO_0002432 gene knock in http://www.bioassayontology.org/bao#BAO_0002431 gene expression modulation method A Knock-in refers to a genetic engineering method that involves the insertion of a protein coding cDNA sequence at a particular locus in an organism's chromosome. The difference between knock-in technology and transgenic technology is that a knock-in involves a gene inserted into a specific locus, and is a "targeted" insertion. http://www.bioassayontology.org/bao#BAO_0002442 gene overexpression http://www.bioassayontology.org/bao#BAO_0002431 gene expression modulation method Gene overexpression refers to genetic techniques in which an organism or cell line is engineered to express increased levels of a gene. http://www.bioassayontology.org/bao#BAO_0000376 fold inhibition http://www.bioassayontology.org/bao#BAO_0000193 fold change The ratio of biological activity in the absence of an exogenous substance to that in its presence. This result type is used exclusively with single point (screening concentration) assays. http://www.bioassayontology.org/bao#BAO_0002433 gene knockdown http://www.bioassayontology.org/bao#BAO_0002431 gene expression modulation method Gene knockdown refers to techniques by which the expression of one or more of an organism's genes is reduced, either through genetic modification (a change in the DNA of one of the organism's chromosomes) or by treatment with a reagent such as a short DNA or RNA oligonucleotide with a sequence complementary to either an mRNA transcript or a gene. http://www.bioassayontology.org/bao#BAO_0000457 brightfield microscopy http://www.bioassayontology.org/bao#BAO_0000451 optical microscopy In brightfield microscopy, sample is illuminated with transmitted white light from below and observed from above. http://www.bioassayontology.org/bao#BAO_0000631 group a streptococcus http://www.bioassayontology.org/bao#BAO_0000364 bacterium Causes mild infections such as "strep throat" to severe diseases such as necrotizing fasciitis and streptococcal toxic shock syndrome. http://www.bioassayontology.org/bao#BAO_0000450 fluorescence microscopy http://www.bioassayontology.org/bao#BAO_0000451 optical microscopy Fluorescence microscopy is used to image the distribution of molecules based on the properties of fluorescence emission. Excitation of fluorescent molecules with a specific wavelength results in the production of an image by the secondary fluorescence emission at longer wavelengths. http://www.bioassayontology.org/bao#BAO_0000506 gene array http://www.bioassayontology.org/bao#BAO_0000504 nucleic acid array Gene arrays include a collection of gene-specific nucleic acids that have been placed at defined locations on a solid support, either by spotting or direct synthesis. Labeled nucleic acids from a sample are hybridized with target genes on the array and the signals measured, which reflects the composition of the sample nucleic acids. http://www.bioassayontology.org/bao#BAO_0002646 isoform http://www.bioassayontology.org/bao#BAO_0000013 primary structure A quality of a protein that harbors a variation from the native protein (called canonical form), which could arise due to alternative promoter usage, alternative splicing, alternative translation initiation and ribosomal frameshifting. http://www.bioassayontology.org/bao#BAO_0002441 gene knockout http://www.bioassayontology.org/bao#BAO_0002431 gene expression modulation method A gene knockout is a genetic technique in which an organism is engineered to carry genes that have been made inoperative (have been "knocked out" of the organism). http://www.bioassayontology.org/bao#BAO_0000079 negative control http://www.bioassayontology.org/bao#BAO_0000072 assay control It is the role played by the solvent (e.g. DMSO) in which the perturbagen was dissolved. The negative control is used to determine the base-line to compare the effect of the test perturbagen. http://www.bioassayontology.org/bao#BAO_0002112 emission filter http://www.bioassayontology.org/bao#BAO_0002110 fluorescence microscope filter An emission filter is an optical-glass filter used in fluorescence microscopy for selection of the emission wavelength of light from a fluorescent molecule, e.g., fluorophore or dye. http://www.bioassayontology.org/bao#BAO_0000063 voltage clamp http://www.bioassayontology.org/bao#BAO_0000382 microelectrode measurement The voltage clamp technique is used to measure the ion currents across an excitable cell membrane, such as neuronal membrane, while holding the membrane voltage at a constant level. The neuronal membrane contains different kinds of ion channels including voltage gated ion channels. Manipulation of the membrane voltage using voltage clamping allows the current-voltage relationships of these ion channels to be studied. http://purl.obolibrary.org/obo/DOID_0080599 Coronavirus infectious disease http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that has_material_basis_in Coronavirus. http://purl.obolibrary.org/obo/DOID_0080602 benign teratoma http://purl.obolibrary.org/obo/DOID_0080601 germ cell benign neoplasm A germ cell benign neoplasm that derives_from mature tissue elements or a limited amount of immature tissue elements. http://www.bioassayontology.org/bao#BAO_0000191 IC80 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint The effective concentration of an inhibitor, which produces 80% of the maximum possible response for that inhibitor. http://www.bioassayontology.org/bao#BAO_0000837 Ac-WEHD-CHO http://www.bioassayontology.org/bao#BAO_0000325 peptide Ac-Trp-Glu-His-Asp-CHO Very potent reversible inhibitor of caspase-1 (ICE) that contains the optimal tetrapeptide recognition motif for this enzyme. With a Ki of 56 pM, it displays the most potent reversible, peptide-based inhibitors described for any protease. For caspase-8 a Ki of 21.1 nM has been reported. http://www.bioassayontology.org/bao#BAO_0000118 DMSO http://www.bioassayontology.org/bao#BAO_0003043 molecular entity Dimethyl sulfoxide (DMSO) is a common organic solvent that is used to solubilize the chemical compounds prior to their addition to an assay. DMSO can have a significant impact on enzyme activity and the concentration of DMSO in the wells containing compound should be identical to the concentration of DMSO in the control wells. DMSO can also impact the solubility of a compound and its observed potency. Therefore, the concentration of DMSO should be consistent in replicate experiments. http://www.bioassayontology.org/bao#BAO_0002439 gene knockdown by antisense RNA http://www.bioassayontology.org/bao#BAO_0002433 gene knockdown Antisense RNA is a single-stranded RNA that is complementary to a messenger RNA (mRNA) strand transcribed within a cell. Antisense RNA may be introduced into a cell to inhibit translation of a complementary mRNA by base pairing to it and physically obstructing the translation machinery. http://www.bioassayontology.org/bao#BAO_0002024 growth factor http://www.bioassayontology.org/bao#BAO_0000022 endogenous ligand The role played by a protein in initiating cell division via cell signaling, subsequent to binding to its cognate cell surface receptor. http://www.bioassayontology.org/bao#BAO_0000363 fluorescence intensity http://www.bioassayontology.org/bao#BAO_0000046 fluorescence method Fluorescence intensity is the measure of fluorescence from a sample. http://www.bioassayontology.org/bao#BAO_0003018 DNA region http://www.bioassayontology.org/bao#BAO_0003114 assay biology component The categorization of different functional or non-functional elements in DNA. http://www.bioassayontology.org/bao#BAO_0001017 SNC80 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity A highly selective and potent non-peptide δ-opioid agonist, 2000-fold selective over μ-opioid receptors. (+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-di methyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethyl benzamide http://www.bioassayontology.org/bao#BAO_0002882 AC500 absolute http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint The compound concentration at which the fitted curve passes activity threshold 500. http://www.bioassayontology.org/bao#BAO_0000465 unpurified http://www.bioassayontology.org/bao#BAO_0002619 categorical purity Crude protein preparation http://www.bioassayontology.org/bao#BAO_0002490 one-hybrid assay http://www.bioassayontology.org/bao#BAO_0002489 hybrid screening The one-hybrid variation of the hybrid screening technique is designed to investigate protein-DNA interactions and uses a single fusion protein in which the AD is linked directly to the binding domain. http://purl.obolibrary.org/obo/DOID_0080690 RASopathy http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that has_material_basis_in mutations in genes that alter the Ras subfamily and mitogen-activated protein kinases that control signal transduction. http://purl.obolibrary.org/obo/DOID_0111866 trichothiodystrophy http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome characterized by sparse, brittle, sulfur-deficient hair that is easily broken and in more severe cases delayed development, significant intellectual disability, and recurrent infections. http://purl.obolibrary.org/obo/ERO_0001500 liquid chromatography http://www.bioassayontology.org/bao#BAO_0040031 size separation method A chromatography technique in which the mobile phase is a liquid and is carried out either in a column or a plane for the purpose of separating mixtures. http://purl.obolibrary.org/obo/ERO_0002176 isobaric labeling http://www.bioassayontology.org/bao#BAO_0040014 protein abundance method A mass spectrometry labeling technique in which peptides or proteins are labeled with various chemical groups that are isobaric, or the same in mass, but which fragment during tandem mass spectrometry to yield reporter ions of different mass. http://www.ebi.ac.uk/efo/EFO_0001272 adult http://purl.obolibrary.org/obo/UBERON_0000113 post-juvenile adult stage A maturity quality inhering in an individual by virtue of the individual having attained sexual maturity and full growth http://www.ebi.ac.uk/efo/EFO_0002562 embryonic day 11.5 http://purl.obolibrary.org/obo/UBERON_0000068 embryo stage mouse embryo stage at age 11.5 days http://www.ebi.ac.uk/efo/EFO_0002563 embryonic day 12.5 http://purl.obolibrary.org/obo/UBERON_0000068 embryo stage mouse embryo stage at age 12.5 days http://www.ebi.ac.uk/efo/EFO_0002564 embryonic day 13.5 http://purl.obolibrary.org/obo/UBERON_0000068 embryo stage mouse embryo stage at age 13.5 days http://www.ebi.ac.uk/efo/EFO_0002565 embryonic day 14.5 http://purl.obolibrary.org/obo/UBERON_0000068 embryo stage mouse embryo stage at age 14.5 days http://www.ebi.ac.uk/efo/EFO_0002566 embryonic day 15.5 http://purl.obolibrary.org/obo/UBERON_0000068 embryo stage mouse embryo stage at age 15.5 days http://www.ebi.ac.uk/efo/EFO_0002567 embryonic day 16.5 http://purl.obolibrary.org/obo/UBERON_0000068 embryo stage mouse embryo stage at age 16.5 days http://www.ebi.ac.uk/efo/EFO_0002568 embryonic day 17.5 http://purl.obolibrary.org/obo/UBERON_0000068 embryo stage mouse embryo stage at age 17.5 days http://www.ebi.ac.uk/efo/EFO_0002569 embryonic day 18 http://purl.obolibrary.org/obo/UBERON_0000068 embryo stage mouse embryo stage at age 18 days http://www.ebi.ac.uk/efo/EFO_0002570 embryonic day 18.5 http://purl.obolibrary.org/obo/UBERON_0000068 embryo stage mouse embryo stage at age 18.5 days http://www.ebi.ac.uk/efo/EFO_0002948 postnatal http://purl.obolibrary.org/obo/UBERON_0000105 life cycle stage The time period after birth. http://purl.obolibrary.org/obo/NCIT_C18639 Quantitative Autoradiography http://www.bioassayontology.org/bao#BAO_0002532 tissue distribution assay Autoradiographic analysis performed in accordance with specified guidelines that will result in a defined correspondence between the intensity of the autoradiographic image and the amount of radioactivity present in the sample. This permits assignment of a value to the amount of radioactive material in the object under study. http://purl.obolibrary.org/obo/NCIT_C18803 Gene Knock-Out Model http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics Models of human disease produced through gene knockout methods http://purl.obolibrary.org/obo/NCIT_C18996 Renal Pharmacology http://www.bioassayontology.org/bao#BAO_0002533 safety pharmacology assay The science concerned with drugs and their actions and uses in kidney biology and the treatment of kidney disease. http://purl.obolibrary.org/obo/NCIT_C19286 Tissue Slice Technology http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics A technology used for preclinical research as an alternative to some animal testing. Micrometer-thin slices of various organs are incubated with various experimental compounds for assays involving toxicology, absorption, distribution, and metabolism. http://purl.obolibrary.org/obo/NCIT_C19425 Migration Assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics An in vitro assay in which cultured cells are monitored and analyzed for their ability to move into an acellular area of a culture material. http://purl.obolibrary.org/obo/NCIT_C19812 Xenograft Model http://purl.obolibrary.org/obo/NCIT_C79367 Pharmacology: Pharmacodynamic Drug Interactions An experimental system in which (usually) human tumor cells are transplanted into immunocompromised mice that do not reject human cells; cells may be implanted under the skin or into the organ type in which the tumor originated. These model systems may be used for drug development and studies of molecular biological mechanisms of cancer. http://purl.obolibrary.org/obo/NCIT_C20604 Affinity http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics The strength of noncovalent chemical binding between two substances as measured by the dissociation constant of the complex. http://purl.obolibrary.org/obo/DOID_0070309 absence epilepsy http://purl.obolibrary.org/obo/DOID_0050701 electroclinical syndrome An electroclinical syndrome characterized by the occurrence of generalized onset seizures that cause lapses in awareness, begin and end abruptly, typically last only a few seconds and are associated with abnormal spike-wave discharges as seen by electroencephalogram. http://purl.obolibrary.org/obo/DOID_0080320 peripheral nervous system benign neoplasm http://purl.obolibrary.org/obo/DOID_0060090 central nervous system benign neoplasm A central nervous system benign neoplasm the is located_in the peripheral nervous system. http://purl.obolibrary.org/obo/DOID_0080321 autonomic nervous system benign neoplasm http://purl.obolibrary.org/obo/DOID_0080320 peripheral nervous system benign neoplasm A peripheral nervous system benign neoplasm that is located_in the autonomic nervous system. http://purl.obolibrary.org/obo/DOID_0080322 polycystic kidney disease http://purl.obolibrary.org/obo/DOID_2975 cystic kidney disease A cystic kidney disease that is characterized by the growth of fluid-filled cysts in the kidneys that reduces kidney function and may lead to kidney failure. http://purl.obolibrary.org/obo/DOID_60000 appendix disease http://purl.obolibrary.org/obo/DOID_77 gastrointestinal system disease A gastrointestinal system disease that is located_in the appendix. http://purl.obolibrary.org/obo/DOID_0080630 B-lymphoblastic leukemia/lymphoma http://purl.obolibrary.org/obo/DOID_0080638 B-cell acute lymphoblastic leukemia A B-cell acute lymphoblastic leukemia that is characterized by the presence of too many B-cell lymphoblasts in the blood and bone marrow. http://www.bioassayontology.org/bao#BAO_0002208 SplitsTree phylogenetic analysis http://www.bioassayontology.org/bao#BAO_0002206 computational phylogenetic analysis Program for inferring phylogenetic trees or, more generally, phylogenetic networks from various types of data such as a sequence alignment, a distance matrix or a set of trees. http://www.bioassayontology.org/bao#BAO_0000089 wild type http://purl.obolibrary.org/obo/PATO_0001995 organismal quality The phenotype of an organism that is most common in nature and was unmodified. http://www.bioassayontology.org/bao#BAO_0000599 EC30 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint The effective concentration of an agonist, which produces 30% of the maximum possible response for that agonist. http://www.bioassayontology.org/bao#BAO_0002414 Karl Fischer titration http://www.bioassayontology.org/bao#BAO_0002413 titration method Karl Fischer titration is a classic titration method in analytical chemistry that uses coulometric or volumetric titration to determine trace amounts of water in a sample. It was invented in 1935 by the German chemist Karl Fischer. http://www.bioassayontology.org/bao#BAO_0002771 AUC(oral) http://www.bioassayontology.org/bao#BAO_0002120 AUC The area under the drug concentration-time curve following an oral dose. http://www.bioassayontology.org/bao#BAO_0000899 emory university molecular libraries screening center http://www.bioassayontology.org/bao#BAO_0000709 research institute It is an MLSCN (pilot phase) screening center. http://purl.obolibrary.org/obo/NCIT_C122936 Patient Derived Xenograft http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics The transfer of a tumor fragment from a patient into an immunodeficient mouse. http://www.bioassayontology.org/bao#BAO_0000528 z-prime factor http://www.bioassayontology.org/bao#BAO_0000028 assay quality assessment method It describes the assay dynamic range considering range and data variation: Z'=1-{3x[StdDev(poscontrol)+StdDev(negcontrol)]/[Avg(poscontrol)-Avg(negcontrol)]} http://purl.obolibrary.org/obo/NCIT_C127803 Dose Response Study http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics A study of the effect of dose changes on the efficacy of a drug in order to determine the dose-response relationship and optimal dose of a therapy. http://purl.obolibrary.org/obo/NCIT_C16681 Histology http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics The study of the structure of the cells and their arrangement to constitute tissues and, finally, the association among these to form organs. In pathology, the microscopic process of identifying normal and abnormal morphologic characteristics in tissues, by employing various cytochemical and immunocytochemical stains. http://purl.obolibrary.org/obo/NCIT_C17376 Mutagenesis http://purl.obolibrary.org/obo/NCIT_C79367 Pharmacology: Pharmacodynamic Drug Interactions Production of genetic alterations by any technique, including chemicals, radiation, recombination, or other molecular biology methods. http://purl.obolibrary.org/obo/NCIT_C18079 Cardiovascular Pharmacology http://www.bioassayontology.org/bao#BAO_0002533 safety pharmacology assay Cardiovascular Pharmacology; the study of the effects of drugs upon the heart or circulatory system http://www.bioassayontology.org/bao#BAO_0000007 nucleosome format http://www.bioassayontology.org/bao#BAO_0000220 subcellular format They are the basic repeating units of the eukaryotic chromatin consisting of DNA wound around a histone protein core. http://www.bioassayontology.org/bao#BAO_0000008 bioassay type http://www.bioassayontology.org/bao#BAO_0003112 assay bioassay component Categorization of bioassays based on the property or process that the assay is interrogating, e.g. ADMET, functional, etc. http://www.bioassayontology.org/bao#BAO_0000009 ADMET http://www.bioassayontology.org/bao#BAO_0000008 bioassay type ADMET stands for absorption, distribution, metabolism, excretion and toxicity. Admet assays are performed for verifying the bio-availability, toxicity, metabolic stability, and drug-drug interaction potential of drugs: They quantify absorption of drugs in the intestine which is dependent on their solubility; distribution which ascertains their binding to plasma proteins, central nervous system penetration; metabolism where the in vivo clearance is monitored; and finally, toxicity in terms of inhibition of liver cytochrome p450 enzymes or hERG which could cause drug-drug interactions and cardiac arrhythmias, respectively. http://www.bioassayontology.org/bao#BAO_0000013 primary structure http://www.bioassayontology.org/bao#BAO_0000138 molecular structure The quality of a biological macromolecule (DNA, RNA or protein), which could either be unmodified' (native) or modified, e.g., methylated, phosphorylated, etc. http://www.bioassayontology.org/bao#BAO_0000015 bioassay http://www.bioassayontology.org/bao#BAO_0003112 assay bioassay component A set of instructions, methodology, operations, required reagents, instruments to carry out experiments for the purpose of testing the effect of a perturbing agent in a biological model system, measuring one or multiple effect(s) of the agent facilitated by an assay design method translate the perturbation into a detectable signal to arrive at one or multiple endpoint(s) that quantify or qualify the extent of the perturbation. Bioassay is described by multiple bioassay components: assay format, biology (biological participants in various role and processes), design method, physical detection method / technology, screened entity, and endpoint. Bioassay includes one or multiple measure groups to describe panel, profiling, multiparametric (or multiplexed) assays (assays that measure more than one effect of the perturbagen on the system that is screened). http://www.bioassayontology.org/bao#BAO_0000016 protein substrate and ligand constant http://www.bioassayontology.org/bao#BAO_0000179 endpoint They are used to express the binding interactions between labeled or unlabeled ligands with protein receptors and include Bmax, Kd, etc. http://www.bioassayontology.org/bao#BAO_0000019 assay format http://www.bioassayontology.org/bao#BAO_0003113 assay format component Assay format is a conceptualization of assays based on the biological and / or chemical features of the experimental system. For example assay formats include biochemical assays - referring to assays with purified protein, cell-based - referring to assays in whole cells, or organism-based - referring to assays performed in an organism. http://www.bioassayontology.org/bao#BAO_0000026 bioassay specification http://www.bioassayontology.org/bao#BAO_0003112 assay bioassay component Description of an experiment carried out for the purpose of screening a perturbing agent in a biological system, measuring the effect of the agents using specified technology, and arriving at endpoints that satisfy particular criteria. http://www.bioassayontology.org/bao#BAO_0000027 assay provider http://www.bioassayontology.org/bao#BAO_0002900 researcher role The role of a scientist who has designed an assay and requested it to be run at a screening center. http://www.bioassayontology.org/bao#BAO_0000028 assay quality assessment method http://www.bioassayontology.org/bao#BAO_0002754 assay data processing method Commonly used statistical parameters for monitoring assay quality include Z and Z' factors. Prior to starting a large screen, and after assay optimization and miniaturization, pilot screens are performed to assess the quality of the assay run and to assess / validate the suitability of a assay for a high-throughput screening run. http://www.bioassayontology.org/bao#BAO_0000029 assay screening campaign stage http://www.bioassayontology.org/bao#BAO_0002933 experimental specification The assay stage describes the purpose of the assay in an assay campaign. Assay stage also relates to the order of assays in a screening campaign. For example the primary assay, which is performed first, identifies hits. The primary hits are then confirmed in a confirmatory assay. Subsequent secondary assays are run to eliminate compounds that are not of interest or to confirm hits using an alternate design / technology, or to further characterize compounds. Whether an assay is run in single concentration or concentration response is defined in the class 'assay measurement throughput quality'. For example primary assays are typically run in single concentration with single measurements. However, the NCGC runs qHTS primary assays as concentration-response assays. http://www.bioassayontology.org/bao#BAO_0000030 confirmatory assay http://www.bioassayontology.org/bao#BAO_0000029 assay screening campaign stage Assay performed to confirm activity of compounds identified in the primary screen. It can be performed as replicate measurements at a single screening concentration or as concentration-response assay. http://www.bioassayontology.org/bao#BAO_0000032 secondary assay http://www.bioassayontology.org/bao#BAO_0000029 assay screening campaign stage Additional assays following the confirmatory stage to confirm the biological activity of chemical entities via a different type of assay or to eliminate certain active compounds based on their mechanism of action, toxicity or activity profile. Secondary assays can also include selectivity and specificity assays. http://www.bioassayontology.org/bao#BAO_0000033 Bmax http://www.bioassayontology.org/bao#BAO_0000587 binding constant It is the amount of drug required to saturate a population of receptors and a measure of the number of receptors present in the sample. It is derived from Scatchard plot of binding data. It is analogous to Vmax in enzyme kinetics. The units of Bmax include cpm, sites/cell or fmol/mg. http://graphpad.com/curvefit/fitting_specific_binding_.htm http://www.bioassayontology.org/bao#BAO_0000035 physical detection method http://www.bioassayontology.org/bao#BAO_0002753 assay method component The physical method (technology) used to measure / readout the effect caused by a perturbagen in the assay environment. http://www.bioassayontology.org/bao#BAO_0000040 measure group http://www.bioassayontology.org/bao#BAO_0003112 assay bioassay component Measure group is used to group and link multiple (different) sets of experimental results to one bioassay. Measure groups thus facilitate the description of multiparametric (or multiplexed) assays, that measure more than one effect of the perturbagen on the system that is screened. It also facilitate the definition of panel and profiling assays, e.g. assays that test compounds against multiple (protein) targets. Compare definition of bioassay. Measure group links to those classes that can vary among different measurements of a panel assay, profiling assay, multiparametric assay, e.g. target, assay design method, physical detection method, endpoint. Measure group is also used to define derived endpoints, for example concentration-response endpoints obtained by curve fitting a set of results from the same compound tested in the same assay at different concentrations. http://www.bioassayontology.org/bao#BAO_0000043 endpoint qualifier http://www.bioassayontology.org/bao#BAO_0002754 assay data processing method Qualifies the endpoint as either the exact value (=) or less than (<) or greater than (>) the endpoint value specified. In case of less than or greater than, the endpoint cutoff is often determined manually; for example in a concentration response experiment the tested compound can be inactive at the minimum tested concentration; or a compound can still be active even at the lowest tested concentration. http://www.bioassayontology.org/bao#BAO_0000045 luminescence method http://www.bioassayontology.org/bao#BAO_0000035 physical detection method The emission of light from a substance that occurs from an electronically excited state which is reached either by a physical, mechanical, or chemical mechanism. http://www.bioassayontology.org/bao#BAO_0000048 conformation determination method http://www.bioassayontology.org/bao#BAO_0002202 assay design method This technology relates to measurement of protein and nucleic acid conformational properties. Proteins undergo changes to their tertiary structure upon heating, binding to perturbagens, other proteins and substrates. Nucleic acids have characteristic secondary structures, which include the B-family of structures, A-form, Z-form, guanine quadruplexes, cytosine quadruplexes, triplexes, etc. Information about conformational properties of protein and nucleic acids can be obtained by circular dichroism spectroscopy, thermal shift, fluorescence resonance energy transfer (FRET), nuclear magnetic resonance (NMR), X-ray crystallography, etc. http://www.bioassayontology.org/bao#BAO_0000049 spectrophotometry method http://www.bioassayontology.org/bao#BAO_0000035 physical detection method Spectrophotometry involves the use of a spectrophotometer to measure the amount of light that a sample absorbs. The instrument operates by passing a beam of light through a sample and measuring the intensity of light reaching a detector. http://www.bioassayontology.org/bao#BAO_0000050 bioluminescence http://www.bioassayontology.org/bao#BAO_0000045 luminescence method Bioluminescence refers to the production and emission of light by a living organism. Bioluminescence is a naturally occurring form of chemiluminescence whereby energy is released by a chemical reaction in the form of light emission. The chemical reaction can occur either inside or outside the cell, and can be detected using a plate reader or a charge-coupled device (CCD) camera. http://www.bioassayontology.org/bao#BAO_0000051 chemiluminescence http://www.bioassayontology.org/bao#BAO_0000045 luminescence method Chemiluminescence is the generation of light as a result of a chemical reaction using synthetic compounds and usually involving a highly oxidized species such as peroxide. http://www.bioassayontology.org/bao#BAO_0000057 optical based http://www.bioassayontology.org/bao#BAO_0000427 label free method These biosensors employ evanescent waves (surface plasmon resonance, resonant waveguide grating) or interference of light waves to characterize the cellular processes that are taking place at or near the sensor surface: e.g. to study the affinity of a sample to the biological receptors immobilized on the sensor surface. http://www.bioassayontology.org/bao#BAO_0000058 thermal shift http://www.bioassayontology.org/bao#BAO_0000046 fluorescence method Upon heating, a protein unfolds and loses the native conformation. Binding of a small molecule can often stabilize the protein conformation, resulting in a higher unfolding temperature. The temperature shift in unfolding can be detected using a fluorescent dye, which is sensitive to the protein environment. http://www.bioassayontology.org/bao#BAO_0000060 current clamp http://www.bioassayontology.org/bao#BAO_0000382 microelectrode measurement The current clamp technique is used to measure biological voltages such as the action potential of an excitable cell with a microelectrode while keeping electrical current through the recording electrode constant. It can be used for both extracellular and intracellular recordings. http://www.bioassayontology.org/bao#BAO_0000061 impedance http://www.bioassayontology.org/bao#BAO_0000163 electrical sensor Impedance biosensors measure the electrical opposition of an interface in AC steady state with constant DC bias conditions. This is accomplished by imposing a small sinusoidal voltage at a particular frequency and measuring the resulting current; the process can be repeated at different frequencies. The current-voltage ratio gives the impedance. http://www.bioassayontology.org/bao#BAO_0000062 patch clamp http://www.bioassayontology.org/bao#BAO_0000382 microelectrode measurement The patch clamping technique is refined from the voltage clamp technique, wherein a blunt electrode is placed on the surface of the cell membrane. It is a common intracellular recording technique in electrophysiology that allows either the measurement of current passing through individual ion channels in cells or through whole cells. Suction is applied via the blunt electrode (glass pipette in classical patch clamp technique) to create a high resistance (gigaohm) between the electrode and cell surface. This seal isolates the ion channels within the patch from the rest of the membrane and allows the neurophysiologist to record only from these ion channels. http://www.bioassayontology.org/bao#BAO_0000064 total internal reflection fluorescence microscopy http://www.bioassayontology.org/bao#BAO_0000450 fluorescence microscopy This technique probes the surface of fluorescently-labeled living cells with an evanescent wave generated by a light beam traveling between two media of differing refractive indices. An incident laser beam is reflected at a critical angle (total internal reflection) when it encounters the interface between a microscope glass slide and the aqueous medium containing the cells. Only fluorophores which are within a few nanometers of the surface are excited, while those farther away are not, making possible the study the interactions at the cell surface. http://www.bioassayontology.org/bao#BAO_0000067 fiber optic waveguide http://www.bioassayontology.org/bao#BAO_0000057 optical based It is based on the ability of a transparent substance, such as glass to conduct some of the visible or near-visible light to its interior by means of internal reflection. http://www.bioassayontology.org/bao#BAO_0000068 optical waveguide grating http://www.bioassayontology.org/bao#BAO_0000057 optical based The optical grating coupler sensor responds to the change of optical refractive index of the liquid or gas cover medium and to the adsorption or binding of molecules on the surface. The optical grating coupler sensor chip is based on a fine optical grating prepared on a thin waveguide layer carried by a glass substrate. The optical grating couples the light of a He-Ne laser at a given resonance angle into the waveguide layer. This incoupling angle is very sensitive to the presence of adsorbed molecules and to any change of refractive index of the medium covering the surface of the chip. By precise measurement of the incoupling angle, the amount of the adsorbed material can be determined with ultra high sensitivity. http://www.bioassayontology.org/bao#BAO_0000070 absorbance http://www.bioassayontology.org/bao#BAO_0000049 spectrophotometry method The absorbance of a beam of collimated monochromatic radiation in a homogeneous isotropic medium is proportional to the absorption path length and to the concentration of the absorbing species. Absorbance is a logarithmic measure of the amount of light (at a specific wavelength) that is absorbed when passing through a sample. A= -log10(I/I0), where A is absorbance, I is the intensity of incident light and I0 is the intensity of light transmitted after passing through the sample. http://www.bioassayontology.org/bao#BAO_0000071 transmittance http://www.bioassayontology.org/bao#BAO_0000049 spectrophotometry method The transmittance of a sample is the ratio of the intensity of the light that has passed through the sample to the intensity of the light when it entered the sample (T = Iout / Iin ). To convert between the absorbance and transmittance scales, the following equation is used: A = -log T = - log (I / Io). http://www.bioassayontology.org/bao#BAO_0000072 assay control http://purl.obolibrary.org/obo/CHEBI_33232 application The role of a compound that is routinely run in the same manner as the test compounds in every run of the assay. This term does not refer to the plate controls used to define the maximum and minimum responses, and they may or may not be a “literature standard” or “reference” compound. http://www.bioassayontology.org/bao#BAO_0000073 phospholipid redistribution estimation http://www.bioassayontology.org/bao#BAO_0000127 viability measurement method In a viable cell, the phospholipid, phosphatidyl serine (PS) is localized on the inner leaflet of the cell membrane facing the cytosol. When the cell is undergoing apoptosis, the cell membrane loses its phospholipid asymmetry and exposes PS on the outer layer of the membrane. Annexin V specifically binds PS. Hence, apoptotic cells can be detected by staining with FITC conjugated Annexin V followed by flow cytometry. http://www.bioassayontology.org/bao#BAO_0000075 endpoint normalization method http://www.bioassayontology.org/bao#BAO_0002754 assay data processing method Two kinds of inference errors can occur after screening at single perturbagen concentration: false positives and false negatives. To correct for this, the raw data is normalized using different statistical correction methods, namely, normalized percent distribution, Z-score, B-score, etc to derive at these endpoints. http://www.bioassayontology.org/bao#BAO_0000077 unit of measurement http://www.bioassayontology.org/bao#BAO_0003115 assay result component It is the definite magnitude of a physical quantity or of time. It has a quantity and a unit associated with it. http://www.bioassayontology.org/bao#BAO_0000080 positive control http://www.bioassayontology.org/bao#BAO_0000072 assay control The role of a chemical compound or reagent used in each plate of an assay to normalize the response of the test perturbagens (by plate). Compounds that can have a positive control role are known from previous experiments or is a previously established standard. It is usually highly active resulting in a strong response of the intended effect. In an inhibition assay the positive control would usually result in the complete inhibition, which is then used for normalization (i.e. set as 100%). In an activation assay it would be activator used to normalize activity. Using controls provides an external reference and reduces the number of false negatives and false positives. http://www.bioassayontology.org/bao#BAO_0000084 ligand function mode of action http://www.bioassayontology.org/bao#BAO_0000074 mode of action Data measuring the biological effect of a compound, e.g. % cell death, activation of reporter gene expression, inhibition of enzyme activity, etc. http://www.bioassayontology.org/bao#BAO_0000085 irreversible binding http://www.bioassayontology.org/bao#BAO_0000476 ligand binding mode of action In this assay, the binding of the ligand to a receptor is permanent and cannot be dissociated by changing the binding conditions such as buffer, salt concentration, etc. http://www.bioassayontology.org/bao#BAO_0000086 reversible binding http://www.bioassayontology.org/bao#BAO_0000476 ligand binding mode of action In this assay, the interaction of the ligand with a receptor can be dissociated by changing the binding conditions, e.g. buffer, salt concentration, etc. http://www.bioassayontology.org/bao#BAO_0000087 activation http://www.bioassayontology.org/bao#BAO_0000084 ligand function mode of action Increase of a predefined stimulus. Unit of Measure is always % when normalized to the dynamic range of the assay. http://www.bioassayontology.org/bao#BAO_0000088 methylated http://www.bioassayontology.org/bao#BAO_0002158 posttranscriptionally modified A quality of a DNA or RNA residue that has a methyl group attached to it. http://www.bioassayontology.org/bao#BAO_0000090 cytotoxicity http://www.bioassayontology.org/bao#BAO_0080004 phenotypic mode of action It is the toxic or cell-death inducing property of a perturbagen. Known cytotoxic agents mediate cell death commonly by necrosis, apoptosis, or autophagy. Cytotoxicity can be detected by measuring various aspects of the death process: e.g. membrane permeability, ATP concentration, DNA fragmentation, etc. http://www.bioassayontology.org/bao#BAO_0000091 inhibition http://www.bioassayontology.org/bao#BAO_0000084 ligand function mode of action Reduction of a predefined stimulus. Unit of Measure is always % when normalized to the dynamic range of the assay. http://www.bioassayontology.org/bao#BAO_0000093 stimulation http://www.bioassayontology.org/bao#BAO_0000084 ligand function mode of action Increase of a predefined stimulus. Unit of Measure is always % when normalized to the dynamic range of the assay. http://www.bioassayontology.org/bao#BAO_0000098 screening concentration http://www.bioassayontology.org/bao#BAO_0000180 concentration endpoint The concentration of a perturbagen used in an assay to elicit the biological effect or perturbation. This typically assumes uniform / equal distribution of the perturbagen / compound in the assay system (typically a screening well). http://www.bioassayontology.org/bao#BAO_0000099 antibiotic resistance http://purl.obolibrary.org/obo/PATO_0001396 cellular quality It is the quality which allows a microorganism to survive after exposure to one or more antibiotics. http://www.bioassayontology.org/bao#BAO_0000100 small-molecule physicochemical format http://www.bioassayontology.org/bao#BAO_0000019 assay format Assays in which the physical and chemical properties of perturbagens are measured, namely, aqueous solubility, octanol water partition, cell permeability models, for e.g. Caco2 cells, parallel artificial membrane permeability assay (PAMPA), etc. http://www.bioassayontology.org/bao#BAO_0000105 feeder cell http://purl.obolibrary.org/obo/CHEBI_24432 biological role The role played by a cell line in supporting the growth of another cell line (e.g., stem cell). The feeder cell, e.g., mouse embryonic fibroblasts (MEFs) provides an adhesive surface to which the stem cells can attach and also secrete factors required for their growth. http://www.bioassayontology.org/bao#BAO_0000110 protein-small molecule interaction assay http://www.bioassayontology.org/bao#BAO_0002989 binding assay It is an interaction between a protein (e.g., receptor, transcription factor) and small molecule (e.g., hormone, organic compound with a low molecular weight (<800 Da)). http://www.bioassayontology.org/bao#BAO_0000114 culture medium http://www.bioassayontology.org/bao#BAO_0003116 material entity The liquid broth used to grow cells, which is optimized for each cell type and includes additives such as growth factors, buffers, amino acids, antibiotics, etc. This information can be obtained from ATCC or found in relevant publications. http://www.bioassayontology.org/bao#BAO_0000123 binding assessment method http://www.bioassayontology.org/bao#BAO_0002202 assay design method Binding reporter technology is used to quantitate the interactions between two molecules, e.g. perturbagen-protein, protein-protein, protein-DNA, etc. The technologies used are radioligand binding, resonance energy transfer, fluorescence polarization, protein fragment complementation assay, and several label-free methods, including surface plasmon resonance, impedance, nuclear magnetic resonance, X-ray diffraction, isothermal titration calorimetry, mass spectrometry, etc. http://www.bioassayontology.org/bao#BAO_0000124 enzyme activity measurement method http://www.bioassayontology.org/bao#BAO_0002202 assay design method It describes the different methods by which an enzyme activity can be measured and the ways it is expressed. This can be measured either directly or coupled to a secondary signal. http://www.bioassayontology.org/bao#BAO_0000127 viability measurement method http://www.bioassayontology.org/bao#BAO_0002202 assay design method Compound cytotoxicity is an important parameter to measure when developing potential human therapeutics. Cytotoxicity is determined as a measure of radioisotope (3H thymidine or 51Cr) release, lactate dehydrogenase release from damaged cells, tetrazolium salt and alamar blue reduction, fluorescent dyes that selectively stain live or dead cells, and decrease in ATP content. The viability reporter technologies measure cell life or death by quantitating ATP content, caspase activity, membrane potential, and so on. http://www.bioassayontology.org/bao#BAO_0000128 in situ immunoassay http://www.bioassayontology.org/bao#BAO_0000129 immunoassay In situ refers to in place or position; undisturbed with respect to the antigen that is being tested in the immunoassay. The protein detection and localization is achieved by visualization under a microscope. http://www.bioassayontology.org/bao#BAO_0000129 immunoassay http://www.bioassayontology.org/bao#BAO_0000126 molecular redistribution determination method It measures the concentration of a substance in a solution based on the specific binding of an antibody to that substance, which produces a measurable signal. The signal measured depends on the label that is associated with this interaction, namely radioactive element (in radioimmunoassays), fluorescent, phosphorescent and chemiluminescent dyes, etc. http://www.bioassayontology.org/bao#BAO_0000130 alphascreen http://www.bioassayontology.org/bao#BAO_0000045 luminescence method This technology measures the interaction of two molecules bioconjugated to donor and acceptor beads. Laser excitation leads to light emission which is directly proportional to the amount of binding, provided molecules are in proximity to cause a chemical reaction (interact). Users have modified this and coupled it to chemiluminescence emission. This technology has been adapted to study protein-protein, protein-DNA and receptor-ligand, immunoassay, phosphorylation and protease reactions. http://www.bioassayontology.org/bao#BAO_0000132 competitive immunoassay http://www.bioassayontology.org/bao#BAO_0000134 ELISA A competitive binding assay is based upon the competition of labeled and unlabeled ligand for a limited number of antibody binding sites. Briefly, the free antigen and antibody are incubated to form antigen-antibody complex and then the complex are bound to antigen-coated surface in the assay plate. The unbound antibody-antigen complex is washed off before adding enzyme-linked secondary antibody against the primary antibody. The substrate is then added and the antigen concentration can then be determined by the signal strength elicited by the enzyme-substrate reaction. In this assay, the enzyme-linked secondary antibody compete with the sample antigen which is associated with the primary antibody. http://www.bioassayontology.org/bao#BAO_0000136 single repetition http://www.bioassayontology.org/bao#BAO_0002178 repetition throughput High-throughput screening (HTS) is a method of scientific experiment which is used in drug discovery. It involves large scale screening of perturbagens against a biological target and requires robotics, liquid handling devices, sensitive detectors and data processing. The results of these experiments provide starting points for drug design or understanding the role of a specific biological process. In HTS, greater than 100,000 compounds are screened per assay. http://www.bioassayontology.org/bao#BAO_0000137 antigen down assay http://www.bioassayontology.org/bao#BAO_0000134 ELISA An antigen-down immunoassay or immunometric assay involves binding the antigen to a solid surface instead of an antibody. Antigen-down immunoassays are used to bind antibodies found in a sample. When the sample is added (such as human serum), the antibodies (IgE for example) from the sample bind to the antigen coated on the plate. http://www.bioassayontology.org/bao#BAO_0000139 direct enzyme activity measurement method http://www.bioassayontology.org/bao#BAO_0000124 enzyme activity measurement method An enzyme is a protein that acts as a catalyst for specific biochemical reaction, converting specific substrates into chemically distinct products. Enzyme activity assays quantify the kinetics of the product formation or substrate depletion in the reaction, which result in fluorescence, luminescence or colorimetric outputs. http://www.bioassayontology.org/bao#BAO_0000142 coupled enzyme activity measurement method http://www.bioassayontology.org/bao#BAO_0000124 enzyme activity measurement method This technology is used to measure the effect of a perturbagen on an enzyme activity, which is coupled to a secondary signal. E.g., the activity of a kinase determines the residual pool of ATP, with ATP being its substrate, which in turn determines the rate of a coupled enzyme luciferase, since ATP is one of its substrates too. http://www.bioassayontology.org/bao#BAO_0000143 percent control http://www.bioassayontology.org/bao#BAO_0000082 percent response Percent control is the response relative to a reference state, typically to a high control. For example it can describe (remaining) activity of a kinase (or e.g. kinase bound to substrate). Percent control could also quantify an inhibitory action depending on control and assay method. http://www.bioassayontology.org/bao#BAO_0000151 beta lactamase induction http://www.bioassayontology.org/bao#BAO_0000125 reporter gene method Beta lactamase gene is attached to the regulatory sequence of a gene of interest. The effect of a perturbagen on the expression of the gene of interest could be easily monitored by the detection of the product of beta lactamase enzyme. http://www.bioassayontology.org/bao#BAO_0000152 luciferase induction http://www.bioassayontology.org/bao#BAO_0000125 reporter gene method Luciferase gene is attached to the regulatory sequence of a gene of interest. The effect of a perturbagen on the expression of the gene of interest could be easily measured by the detection of light emitted as a product the luciferase reaction. http://www.bioassayontology.org/bao#BAO_0000156 high signal control http://www.bioassayontology.org/bao#BAO_0000072 assay control The role played by the substrate, which is titrated without inhibitor to reflect the maximum enzyme activity at each substrate concentration. http://www.bioassayontology.org/bao#BAO_0000158 esterase activity determination http://www.bioassayontology.org/bao#BAO_0000127 viability measurement method Cell viability can be assessed by the presence of cytoplasmic esterases that cleave a lipid-soluble nonfluorescent probe to yield a fluorescent product. The product is charged and is thus retained within the cell if the membrane is intact. Typical probes include fluorescein diacetate (FDA), carboxyfluorescein, and calcein. http://www.bioassayontology.org/bao#BAO_0000159 chromatin condensation visualization http://www.bioassayontology.org/bao#BAO_0000127 viability measurement method Chromatin condensation is one of the morphological changes that occur during apoptosis. It is also known as pyknosis and can be visualized by staining with dyes followed by microscopy. http://www.bioassayontology.org/bao#BAO_0000162 metal ion redistribution assay http://www.bioassayontology.org/bao#BAO_0002999 redistribution assay Metal ions such as copper, iron, magnesium and zinc are transported between different cellular compartments to bring about specific functions. This is regulated by their influx and efflux across membranes, which could occur either by passive diffusion or active transport. http://www.bioassayontology.org/bao#BAO_0000165 caspase activity determination http://www.bioassayontology.org/bao#BAO_0000127 viability measurement method Caspases are cysteine proteases which play an important role in apoptosis. They are synthesized and stored in cells as inactive procaspases. Once apoptosis is initiated in a cell, the procaspases get activated by proteolytic cleavage. This sets in motion a caspase cascade, which leads to the activation of proteins involved in the chromatin fragmentation and finally culminates in cell death. http://www.bioassayontology.org/bao#BAO_0000166 dehydrogenase activity determination http://www.bioassayontology.org/bao#BAO_0000127 viability measurement method An expansion in the number of viable cells results in an increase in the overall activity of mitochondrial dehydrogenases in the sample. The internal environment of the proliferating cell is more reduced than that of non-proliferating cells. Specifically, the ratios of NADPH/NADP, FADH/FAD, FMNH/FMN, and NADH/NAD, increase during proliferation. Compounds such as tetrazolium salts and Alamar Blue, which can be reduced by these metabolic intermediates, can be used to monitor cell proliferation. Their reduction is accompanied by a measurable shift in wavelength with a corresponding change in color. http://www.bioassayontology.org/bao#BAO_0000167 membrane permeability assessment http://www.bioassayontology.org/bao#BAO_0000127 viability measurement method Live cells with intact membranes have the ability to exclude dyes that easily penetrate dead or damaged cells. Examples of the dyes include propidium iodide, 7-amino actinomycin D, and trypan blue. Cells stained with the former two can be quantified by flow cytometry, while the latter is by manual counting using hemocytometer. http://www.bioassayontology.org/bao#BAO_0000168 low signal control http://www.bioassayontology.org/bao#BAO_0000072 assay control The role played by the substrate, which is titrated without enzyme and without inhibitor. The low controls should reflect the signal expected for no enzyme activity at each substrate concentration. Depending on the composition of the inhibitor stocks, DMSO might be needed in the control wells to assure consistency across all the experiments. http://www.bioassayontology.org/bao#BAO_0000170 protease activity determination http://www.bioassayontology.org/bao#BAO_0000127 viability measurement method Live cells have a conserved and constitutive protease activity which serves as a biomarker of cell viability. The live-cell protease activity is measured using a fluorogenic, cell-permeant, peptide substrate (Gly-Phe-AFC). The substrate enters intact cells, where it is cleaved by the live-cell protease activity to generate a fluorescent signal proportional to the number of living cells. The live-cell protease becomes inactive upon loss of membrane integrity and leakage into the surrounding culture medium. http://www.bioassayontology.org/bao#BAO_0000171 lipid http://www.bioassayontology.org/bao#BAO_0003111 biological macromolecule Lipids are a group of naturally occurring organic compounds that are soluble in nonpolar organic solvents, but insoluble in water. Examples include fatty acids, triglycerides, phospholipids, etc. Lipids function to store energy, form a component of cell membrane and as signaling molecules. http://www.bioassayontology.org/bao#BAO_0000174 peptoid http://www.bioassayontology.org/bao#BAO_0003043 molecular entity Peptoids are a class of biomimetic polymers based on oligo-N-substituted glycine backbones, designed to mimic peptides and proteins. Peptoids are resistant to proteolysis and not typically denatured by solvent, temperature, or chemical denaturants. http://www.bioassayontology.org/bao#BAO_0000175 protein http://www.bioassayontology.org/bao#BAO_0003111 biological macromolecule A protein or polypeptide is a long polymer of amino acids joined together by peptide bonds. The sequence of the amino acids is defined by the genetic code. Here, a protein is a perturbagen whereby its ability to modulate a physiological process or a disease pathology is assessed. http://www.bioassayontology.org/bao#BAO_0000176 small molecule http://www.bioassayontology.org/bao#BAO_0000076 screened entity Small molecule is an organic compound with a low molecular weight (<800 Da) which is used to screen against a biological target, e.g. protein, nucleic acid, cell or organism to test its ability to bind it and bring about a change in activity. It is either isolated from a natural source or is synthesized. http://www.bioassayontology.org/bao#BAO_0000178 screening campaign http://www.bioassayontology.org/bao#BAO_0002933 experimental specification Screening campaign incudes a sequence of (assay) experiments performed to identify a compound (or a series of compounds) with a specific function and it is desirable to have a known mechanism of action. It includes primary (screening at single concentration), secondary, and confirmatory (dose response) screens, structure activity relationship (SAR) studies, lead optimization, etc. http://www.bioassayontology.org/bao#BAO_0000179 endpoint http://www.bioassayontology.org/bao#BAO_0003115 assay result component The endpoint is a quantitive or qualitative interpretable standardized representation of a perturbation (a change from a defined reference state of a "closed" model system) that is measured by the bioassay. An endpoint consists of a series of data points, one for each perturbing agent (screened entity) tested the assay. http://www.bioassayontology.org/bao#BAO_0000180 concentration endpoint http://www.bioassayontology.org/bao#BAO_0000179 endpoint It can refer to the screening concentration (for example in a primary assay) or it can be a concentration at which the perturbagen mediates a defined response, such as IC50 or EC50. It always has one value and a concentration unit. http://www.bioassayontology.org/bao#BAO_0000181 response endpoint http://www.bioassayontology.org/bao#BAO_0000179 endpoint Reporting the extent / magnitude of the perturbation (induced by the perturbagen) such as percent inhibition. Response-type endpoints would typically be obtained from a single concentration perturbagen measurement. http://www.bioassayontology.org/bao#BAO_0000187 CC50 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint The effective concentration of a cytotoxic compound, which produces 50% of the maximum possible cell death for that compound. Although the cytotoxic compound induces cell death, we define CC50 as subclass of IC50, because critical cellular processes are inhibited and CC50 is often used as a more specific description of IC50 for cell toxicity assays. Compound cytotoxicity is an important parameter to measure when developing potential human therapeutics. Cytotoxicity can be determined for example as a measure of radioisotope (3H thymidine or 51Cr) release, lactate dehydrogenase release from damaged cells, tetrazolium salt and alamar blue reduction, fluorescent dyes that selectively stain live or dead cells, or decrease in ATP content. ATP levels are detected using a luminescence based assay kit such as CellTiter-Glo (Promega). ATP values higher than controls (untreated cells) indicate proliferation and cultures with ATP concentrations lower than controls indicate cytotoxicity. http://www.bioassayontology.org/bao#BAO_0000190 IC50 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint The effective concentration of an inhibitor, which produces 50% of the maximum possible response for that inhibitor. http://www.bioassayontology.org/bao#BAO_0000192 Ki http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint Ki is the equilibrium inhibitor dissociation constant, the concentration of the competing inhibitor that results in binding to half the enzymes sites at equilibrium in the absence of substrate or other competitors. The Cheng and Prusoff equation: Ki - (IC50) / ( 1+ ([L]/Kd)) relates IC50 to Ki under conditions of competitive binding; Kd equilibrium dissociation constant of the (labeled) ligand, [L] ligand concentration. The Cheng and Prusoff equation: Ki - (IC50) / ( 1+ ([S]/Km)) relates IC50 to Ki under conditions of competitive inhibition; Ki equilibrium enzyme inhibitor dissociation constant; Km Michaelis-Menton constant, [S] substrate concentration. http://www.bioassayontology.org/bao#BAO_0000197 IC50 absolute http://www.bioassayontology.org/bao#BAO_0000190 IC50 Absolute IC50 (calculated from the curve-fit function) is the concentration corresponding to exactly 50 percent inhibition. It is obtained from the curve fit function (back-calculated IC50) and can also be extrapolated. Commonly the relative IC50 is reported; however in cell proliferation assays absolute IC50 is often used. The absolute IC50 can be more reproducible. http://www.bioassayontology.org/bao#BAO_0000201 percent inhibition http://www.bioassayontology.org/bao#BAO_0000082 percent response Percent decrease of a measureable response as a consequence of compound treatment. Unit of Measure is always % when normalized to the dynamic range of the assay. Percent inhibition is expressed relative to a positive control (which results in total inhibition). http://www.bioassayontology.org/bao#BAO_0000215 small molecule probe http://www.bioassayontology.org/bao#BAO_0000176 small molecule A small molecule useful to interrogate a biological system of interest. It has to be active in the system studies, i.e. cell permeable or active in vivo and be sufficiently efficacious and selective. The term probe also refers to the MLI screening effort, which has the goal to generate chemical probes. In addition, the MLI requires a novel chemical probe to be superior to the state of the art in terms of efficacy and selectivity and in-vivo properties. A list of probes generated is available here: http://mli.nih.gov/mli/mlp-probes/ http://www.bioassayontology.org/bao#BAO_0000217 biochemical format http://www.bioassayontology.org/bao#BAO_0000019 assay format It is an in vitro format used to measure the activity of a biological macromolecule, either a purified protein or a nucleic acid. It is most often a homogeneous assay type, but can be heterogeneous if a solid phase such as beads is used to immobilize the macromolecule. http://www.bioassayontology.org/bao#BAO_0000218 organism-based format http://www.bioassayontology.org/bao#BAO_0000019 assay format Involves the use of a living organism, either single or multi-celled, and is a heterogeneous assay type. http://www.bioassayontology.org/bao#BAO_0000219 cell-based format http://www.bioassayontology.org/bao#BAO_0000019 assay format Involves the use of living cells of eukaryotic origin, derived from a multicellular organism, and is a heterogeneous assay type. Typically, this refers to permanent (immortal) cell lines, or primary cells, or some form of stem cells. This is distinct from a single-celled organism-based format (classically bacteria or yeast). http://www.bioassayontology.org/bao#BAO_0000220 subcellular format http://www.bioassayontology.org/bao#BAO_0000366 cell-free format subcellular organelles / component (not individual proteins) obtained via cell lysis and differential centrifugation (or potentially other method of purification / extraction of the organelles) http://www.bioassayontology.org/bao#BAO_0000221 tissue-based format http://www.bioassayontology.org/bao#BAO_0000019 assay format Involves the use of a tissue derived from a living organism and is a heterogeneous assay type. http://www.bioassayontology.org/bao#BAO_0000223 protein complex format http://www.bioassayontology.org/bao#BAO_0000224 protein format Two or more proteins interact to form a stable complex. Each of the members of this complex has a distinct role in mediating the overall function of the complex, which can be as a chaperone (DnaK, DnaJ and grpE), an enzyme (mitochondrial respiratory complexes), a signaling complex (G-proteins), etc. It can be viewed as a quaternary structure of the proteins. http://www.bioassayontology.org/bao#BAO_0000224 protein format http://www.bioassayontology.org/bao#BAO_0000217 biochemical format In this format, the perturbagen targets a protein to regulate its function. http://www.bioassayontology.org/bao#BAO_0000225 nucleic acid format http://www.bioassayontology.org/bao#BAO_0000217 biochemical format In this format, the perturbagen targets a nucleic acid (DNA or RNA) to regulate its function. http://www.bioassayontology.org/bao#BAO_0000228 fused http://www.bioassayontology.org/bao#BAO_0000013 primary structure Fusion proteins or chimeric proteins are created through the joining of two or more cDNAs which encode different proteins. Upon expression, a single polypeptide containing each of the proteins results. Generally, the protein of interest is tagged with a reporter protein, e.g. luciferase, GFP, etc, whose expression could easily be monitored. http://www.bioassayontology.org/bao#BAO_0000237 adhesion http://www.bioassayontology.org/bao#BAO_0000175 protein The proteins located on the cell surface which are involved with the binding with other cells or the extracellular matrix. They belong to 5 families: Immunoglobulin superfamily, integrins, cadherins, selectins and the lymphocyte homing receptors. http://www.bioassayontology.org/bao#BAO_0000238 cell line modification method http://www.bioassayontology.org/bao#BAO_0002197 modification method This describes the type of alterations performed on the cell line, which include plasmid transfection, viral transduction, cell fusion, etc. http://www.bioassayontology.org/bao#BAO_0000239 primary cell http://purl.obolibrary.org/obo/CLO_0000001 细胞系细胞 Cells that are cultured from a subject (tissue or tumor) and which are not immortalized. They can undergo only a limited number of cell divisions prior to reaching senescence. http://www.bioassayontology.org/bao#BAO_0000240 cell fusion method http://www.bioassayontology.org/bao#BAO_0000238 cell line modification method Cell fusion is the formation of a hybrid cell from two different cells of same or different species. After such fusion, one of the parental cells has a dominant phenotype over the other, and the resulting hybrids will have the features of only one of the parental cells. Fusion is performed to understand the dominance of genetic material, DNA recombination events, etc. http://www.bioassayontology.org/bao#BAO_0000242 cybrid cell creation method http://www.bioassayontology.org/bao#BAO_0000240 cell fusion method Cell fusion is the formation of a hybrid cell from two different cells of same or different species. Fusion cybrids are created by fusing a nucleated and an enucleated (nucleus removed) cell. The resulting cybrids have one nucleus, but they contain the mitochondria from both the parental cells. This allows one to study the mitochondrial inheritance and to ascertain the role of mitochondrial DNA mutations in diseases. http://www.bioassayontology.org/bao#BAO_0000243 hybrid cell creation method http://www.bioassayontology.org/bao#BAO_0000240 cell fusion method Cell fusion is the formation of a hybrid cell from two different cells of same or different species. Fusion hybrids are created by fusing two nucleated cells obtained from same or different species. http://www.bioassayontology.org/bao#BAO_0000244 viral transduction method http://www.bioassayontology.org/bao#BAO_0000241 genetic modification method This refers to the infection of cells with either a pathogenic or a modified virus, which introduces viral genome into the cells. Pathogenic viruses include the influenza virus, measles virus, Japanese encephalitis virus, etc. For recombinant expression of proteins in cells or tissues, several types of viruses are utilized, including lentivirus, retrovirus, adenovirus, etc, with each having their own advantages and disadvantages. http://www.bioassayontology.org/bao#BAO_0000245 transfection method http://www.bioassayontology.org/bao#BAO_0000241 genetic modification method This refers to the introduction of nucleic acids into cells using a construct. Plasmids constructs are created by the insertion of a gene or siRNA encoding DNA of interest into a plasmid. The engineered plasmids are introduced into cells by various means, namely, transfection, electroporation, nucleofection, etc which regulates the efficiency and location of gene transfer, for e.g., nucleofection delivers the plasmid directly into the nucleus in contrast to the other methods that deliver into the cytosol. http://www.bioassayontology.org/bao#BAO_0000246 stable transfection http://www.bioassayontology.org/bao#BAO_0000245 transfection method In this method, the introduced plasmid construct is stably integrated in the cellular genome, and is hence a permanent modification of the cells. This is achieved by selecting for cells which express a plasmid-encoded selectable marker, which is commonly an antibiotic resistance protein. http://www.bioassayontology.org/bao#BAO_0000247 transient transfection http://www.bioassayontology.org/bao#BAO_0000245 transfection method It is the temporary introduction of a gene or siRNA encoding DNA of interest into a cell using various plasmids. Usually, the transiently transfected DNA remains in the cell for 2-3 days and is functional: expresses the gene of interest. There are numerous transient transfection reagents and protocols available that have been optimized for various cell lines. http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0003112 assay bioassay component The title of the kit/biologicals used in the assay. http://www.bioassayontology.org/bao#BAO_0000249 cell membrane format http://www.bioassayontology.org/bao#BAO_0000220 subcellular format The thin outer covering of a cell consisting of lipid-bilayer embedded with proteins. It is semi-permeable and is also called "plasma membrane" http://www.bioassayontology.org/bao#BAO_0000250 cytosol format http://www.bioassayontology.org/bao#BAO_0000220 subcellular format The fluid component of cytoplasm, without the organelles and the insoluble cytoplasmic components. http://www.bioassayontology.org/bao#BAO_0000251 microsome format http://www.bioassayontology.org/bao#BAO_0000220 subcellular format Microsomes are vesicle-like structures formed as an artifact from the endoplasmic reticulum after the cell has been ruptured by homogenization. http://www.bioassayontology.org/bao#BAO_0000252 mitochondrion format http://www.bioassayontology.org/bao#BAO_0000220 subcellular format An organelle found in the cytoplasm of eukaryotic cells that metabolizes glucose and other sugars to produce usable energy in the form of ATP. It contains its own genome which encodes proteins, tRNA and rRNA. http://www.bioassayontology.org/bao#BAO_0000253 nuclear extract format http://www.bioassayontology.org/bao#BAO_0000220 subcellular format It is a soluble extract prepared from the cellular nuclei, which are obtained by differential centrifugation of the cell lysate. http://www.bioassayontology.org/bao#BAO_0000254 whole cell lysate format http://www.bioassayontology.org/bao#BAO_0000366 cell-free format A cell whose membrane has been ruptured, either mechanically or by freeze-thawing. The entire cell lysate is used in the assay without extensive purification (or separation). http://www.bioassayontology.org/bao#BAO_0000255 rabbit reticulocyte lysate format http://www.bioassayontology.org/bao#BAO_0000254 whole cell lysate format The lysate contains the cellular components necessary for in vitro protein synthesis (tRNA, ribosomes, amino acids, initiation, elongation and termination factors). It is prepared from rabbit reticulocytes by lysis, followed by treatment with micrococcal nuclease to destroy endogenous mRNA for background reduction. http://www.bioassayontology.org/bao#BAO_0000260 signal increase corresponding to activation http://www.bioassayontology.org/bao#BAO_0080026 signal increase Increase in perturbation (reported by the endpoint mode of action, activation) is correlated to increase in signal. http://www.bioassayontology.org/bao#BAO_0000261 signal decrease corresponding to inhibition http://www.bioassayontology.org/bao#BAO_0080025 signal decrease Increase in perturbation (reported by the endpoint mode of action, inhibition) is correlated to decrease in signal. http://www.bioassayontology.org/bao#BAO_0000269 DNA http://www.bioassayontology.org/bao#BAO_0000011 nucleic acid DNA or deoxyribonucleic acid is the genetic material in all the living things, and some viruses. It is a polymer of nucleotides, with a backbone made of deoxyribose sugar and phosphate groups joined together by ester bonds. http://www.bioassayontology.org/bao#BAO_0000270 RNA http://www.bioassayontology.org/bao#BAO_0000011 nucleic acid RNA or ribonucleic acid is a polymer of nucleotides with a backbone made of ribose sugar and phosphate groups linked together by ester bonds. RNA has the base uracil instead of thymine, which is present in DNA. http://www.bioassayontology.org/bao#BAO_0000274 mRNA http://www.bioassayontology.org/bao#BAO_0000270 RNA mRNA or messenger RNA is a genetic intermediate between DNA and protein. It is transcribed from DNA by RNA polymerases which is further processed by other enzymes. mRNA serves as the template to synthesize proteins on the ribosomes. http://www.bioassayontology.org/bao#BAO_0000275 rRNA http://www.bioassayontology.org/bao#BAO_0000270 RNA rRNA or ribosomal RNAs are present in ribosomes in a cell. Ribosomes are protein translation machinery which can read messenger RNAs and translate that information into proteins. http://www.bioassayontology.org/bao#BAO_0000277 chaperone http://www.bioassayontology.org/bao#BAO_0000365 cytosolic protein They have an essential role in the regulation of protein conformation states. Molecular chaperones help nascent polypeptides fold correctly and multimeric protein complexes assemble properly, and reduce the possibility of protein aggregation. http://www.bioassayontology.org/bao#BAO_0000278 enzyme regulator http://www.bioassayontology.org/bao#BAO_0000175 protein It modulates the activity of an enzyme. http://www.bioassayontology.org/bao#BAO_0000279 enzyme http://www.bioassayontology.org/bao#BAO_0000175 protein Enzymes are biological catalysts involved in important pathways that allow chemical reactions to occur at higher rates (velocities) than would be possible without the enzyme. Enzymes are generally globular proteins that have one or more substrate binding sites. http://www.bioassayontology.org/bao#BAO_0000280 ion channel http://www.bioassayontology.org/bao#BAO_0000285 transmembrane receptor Ion channels are present in the cell membrane. They are pore-forming protein complexes that facilitate diffusion of ions across membranes and thus establish the small voltage gradient across the plasma membrane of living cells. http://www.bioassayontology.org/bao#BAO_0000281 receptor http://www.bioassayontology.org/bao#BAO_0000175 protein A membrane or intracellular protein that specifically binds a known stimulus of cellular activity, such as a hormone, growth factor, antigen, neurotransmitter, drug, etc. http://www.bioassayontology.org/bao#BAO_0000282 transcription factor http://www.bioassayontology.org/bao#BAO_0000175 protein It is a protein that binds to a specific sequence of DNA (upstream of the genes that it regulates) and regulates gene expression. http://www.bioassayontology.org/bao#BAO_0000283 transporter http://www.bioassayontology.org/bao#BAO_0000175 protein A transporter protein is a transmembrane protein that helps transport small molecules and proteins across the membrane. This is done using facilitated diffusion or active transport. http://www.bioassayontology.org/bao#BAO_0000284 G protein coupled receptor http://www.bioassayontology.org/bao#BAO_0000285 transmembrane receptor G protein-coupled receptors (GPCRs), comprise the largest integral membrane protein family with nearly 1000 members. They integrate extracellular signals from hormones, growth factors, neurotransmitters, etc to downstream cellular responses. They are important pharmacological targets, being associated with a number of diseases. Upon ligand binding extracellularly, the GPCR signals through a downstream heterotrimeric G protein complex, consisting of the α, β and γ subunits. http://www.bioassayontology.org/bao#BAO_0000285 transmembrane receptor http://www.bioassayontology.org/bao#BAO_0000281 receptor Transmembrane receptors are integral membrane proteins in either the cell- or organelle-membrane. They bind specific hormones, neurotransmitters, cytokines, growth factors, etc and initiate cell signaling, which results in changes in the cell function. http://www.bioassayontology.org/bao#BAO_0000286 nuclear receptor http://www.bioassayontology.org/bao#BAO_0000281 receptor Nuclear receptors are localized in the cytosol and mediate the activity of hormones and certain vitamins. They are all transcription factors, which upon activation by ligand binding, translocate to the nucleus, bind specific DNA sequence and activate gene expression. http://www.bioassayontology.org/bao#BAO_0000289 ligase http://www.bioassayontology.org/bao#BAO_0000279 enzyme Join together two molecules by synthesis of new C-O, C-S, C-N or C-C bonds with simultaneous breakdown of ATP. http://www.bioassayontology.org/bao#BAO_0000290 lyase http://www.bioassayontology.org/bao#BAO_0000279 enzyme Non-hydrolytic addition or removal of groups from substrates. C-C, C-N, C-O or C-S bonds may be cleaved. http://www.bioassayontology.org/bao#BAO_0000291 oxidoreductase http://www.bioassayontology.org/bao#BAO_0000279 enzyme To catalyze oxidation/reduction reactions; transfer of H and O atoms or electrons from one substance to another. http://www.bioassayontology.org/bao#BAO_0000292 transferase http://www.bioassayontology.org/bao#BAO_0000279 enzyme Transfer of a functional group from one substance to another. The group may be methyl-, acyl-, amino- or phosphate group. http://www.bioassayontology.org/bao#BAO_0000295 phosphatase http://www.bioassayontology.org/bao#BAO_0000287 hydrolase A phosphatase is an enzyme that removes a phosphate group from its substrate by hydrolysis of phosphoric acid esters. http://www.bioassayontology.org/bao#BAO_0000313 morpholino oligonucleotide http://www.bioassayontology.org/bao#BAO_0003043 molecular entity Morpholinos are antisense oligos that bind to specific mRNAs to reduce gene expression. They are small (~25 base) and possess altered back structures compared to DNA or RNA making them resistant to cleavage by nucleases. They are used extensively as tools to investigate zebrafish, Xenopus and sea urchin embryonic development. http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0003111 biological macromolecule Peptide is a short polymer of amino acids, which is generally <50 amino acids long. http://www.bioassayontology.org/bao#BAO_0000334 background control http://www.bioassayontology.org/bao#BAO_0000072 assay control The role played by the reading obtained from wells to which the sample or one of the reagents was not added. This is subtracted from all the experimental readings prior to further analysis. http://www.bioassayontology.org/bao#BAO_0000356 protein preparation method http://www.bioassayontology.org/bao#BAO_0002014 preparation method This describes the method by which a protein is purified from its source. http://www.bioassayontology.org/bao#BAO_0000357 single protein format http://www.bioassayontology.org/bao#BAO_0000224 protein format one protein sequence http://www.bioassayontology.org/bao#BAO_0000360 recombinant expression http://www.bioassayontology.org/bao#BAO_0000356 protein preparation method This involves cloning the cDNA of the gene of interest in a plasmid or viral vector and introducing it into a bacterial, insect or mammalian cell for expression. The expressed protein is then purified after lysing the cells followed by a series of centrifugation and, or chromatography and electrophoresis methods. http://www.bioassayontology.org/bao#BAO_0000365 cytosolic protein http://www.bioassayontology.org/bao#BAO_0000175 protein Proteins localized in the cytosol, but do not belong to the transcription factor, transporter, structural, enzyme, enzyme regulator and nuclear receptor classes of proteins in the cytosol. http://www.bioassayontology.org/bao#BAO_0000366 cell-free format http://www.bioassayontology.org/bao#BAO_0000019 assay format This originates from a cell, but does not use intact (live) cells; does not include biochemical assays, which is one of the major formats that is categorized separately. It is most often a homogeneous assay type, but can be heterogeneous if a solid phase such as beads are used to immobilize the components. http://www.bioassayontology.org/bao#BAO_0000367 membrane protein http://www.bioassayontology.org/bao#BAO_0000175 protein Membrane proteins are associated with the cell membrane. They can be classified into two broad categories http://www.bioassayontology.org/bao#BAO_0000369 secreted http://www.bioassayontology.org/bao#BAO_0000175 protein These proteins are translocated from the inside of the cell to the cell's exterior. Proteins targeted for secretion undergo glycosylation and other postranslational modifications in the endoplasmic reticulum and the golgi complex, and are enclosed in secretory vesicles. The fusion of vesicles to the cell membrane releases the secretory proteins to the exterior. Examples include growth factors, tumor necrosis factors, cytokines, etc. http://www.bioassayontology.org/bao#BAO_0000370 structural http://www.bioassayontology.org/bao#BAO_0000175 protein These proteins constitute the largest class with respect to the total protein mass. They are fibrous proteins, e.g. keratin, actin, myosin, etc whose primary function is to provide scaffolding that maintains cell shape. http://www.bioassayontology.org/bao#BAO_0000371 assay phase characteristic http://www.bioassayontology.org/bao#BAO_0003113 assay format component It refers to whether all the assay components are in solution or some are in solid phase, which determines their ability to scatter light. http://www.bioassayontology.org/bao#BAO_0000372 homogeneous phase http://www.bioassayontology.org/bao#BAO_0000371 assay phase characteristic All assay components exist in solution phase at the time of detection (e.g. none of the components are in beads or cells). Technically no component scatters light. http://www.bioassayontology.org/bao#BAO_0000373 heterogeneous phase http://www.bioassayontology.org/bao#BAO_0000371 assay phase characteristic One or more assay components are present in solid phase at time of detection. (e.g.: cells, beads). http://www.bioassayontology.org/bao#BAO_0000377 membrane potential measurement method http://www.bioassayontology.org/bao#BAO_0002202 assay design method All living cells maintain a resting membrane potential, which is the difference in voltage between the interior and exterior of the cell. Electrically active cells, such as neurons, muscle and endocrine cells undergo changes in membrane potential due to depolarization and hyperpolarization as a result of opening and closing of ion channels. Action potentials are large and rapid changes in membrane potential which are generated as a result of a large depolarization event. In neurons, action potentials are used to transmit signals across neurons, while in muscle and endocrine cells, they lead to intracellular events, such as muscle contraction and hormone release, respectively. In addition, mitochondria possess a trans-membrane potential as a result of their respiratory function. Membrane potential can be measured either by using electrophysiological techniques or by staining with dyes whose binding is dependent on the membrane potential. http://www.bioassayontology.org/bao#BAO_0000378 protein redistribution assay http://www.bioassayontology.org/bao#BAO_0002999 redistribution assay Cellular signaling can bring about the movement of proteins in cells. Upon receiving a cue, proteins undergo posttranslational modifications, e.g. phosphorylation, dephosphorylation, etc, which results in their activation and migration to different compartments, often to the nucleus, where they regulate gene expression. http://www.bioassayontology.org/bao#BAO_0000379 second messenger redistribution assay http://www.bioassayontology.org/bao#BAO_0002999 redistribution assay Second messengers relay signals from the receptors to the cell interior as part of a signaling event. In the process, they amplify the signal. Examples include cAMP, cGMP, calcium, nitric oxide, diacylglycerol, etc, which play important roles in different physiological processes. http://www.bioassayontology.org/bao#BAO_0000382 microelectrode measurement http://www.bioassayontology.org/bao#BAO_0000163 electrical sensor Electrically active cells, such as neurons, muscle and endocrine cells undergo changes in membrane potential due to depolarization and hyperpolarization as a result of opening and closing of ion channels. The electrical recordings from these cells are obtained by the insertion or attaching microelectrodes to these cells. Patch clamp, voltage clamp and current clamp are three ways of studying the current-voltage relationships of these ion channels. http://www.bioassayontology.org/bao#BAO_0000384 summary comment http://www.bioassayontology.org/bao#BAO_0000520 assay description The comment deposited by the assay provider, which summarizes the screening campaign with respect to the identification of lead compounds and chemical probes. http://www.bioassayontology.org/bao#BAO_0000394 protein-nucleotide interaction assay http://www.bioassayontology.org/bao#BAO_0002989 binding assay Protein-nucleotide interaction http://www.bioassayontology.org/bao#BAO_0000402 radioligand binding method http://www.bioassayontology.org/bao#BAO_0000123 binding assessment method It is used for analysis of receptor-ligand interactions in screening applications. It utilizes a radiolabeled ligand and a source of receptor (membranes, soluble/purified). http://www.bioassayontology.org/bao#BAO_0000405 scintillation counting http://www.bioassayontology.org/bao#BAO_0000657 radiometry method It involves the incorporation of radiolabeled precursors into uniform distribution with a liquid medium capable of converting the kinetic energy of nuclear emissions into light energy. A scintillation counter is used to measure ionizing radiation. The scintillation counter consists of a sensor, called a scintillator, made of transparent crystal or an organic liquid that fluoresces when struck by ionizing radiation. A photomultiplier is then used to measure the light emitted by the sensor and is attached to an electronic apparatus that amplifies and quantifies the radiation signal. http://www.bioassayontology.org/bao#BAO_0000406 protein fragment complementation method http://www.bioassayontology.org/bao#BAO_0000123 binding assessment method This is used to study the interaction of two proteins. An enzyme or fluorescent protein is rationally dissected into two fragments and fused to two test proteins, whose interaction is being studied. Binding of the two test proteins results in the reconstitution of the enzyme or fluorescent protein from the two fragments, which can be measured. http://www.bioassayontology.org/bao#BAO_0000408 lysate based http://www.bioassayontology.org/bao#BAO_0000405 scintillation counting This assay is performed to study interaction between a radio-labeled ligand and the receptor in presence of cold ligand. The cells exposed to the radioligand and cold ligand are washed to remove the unbound ligands. They are then lysed and the bound radioactivity is counted in a liquid scintillation counter. http://www.bioassayontology.org/bao#BAO_0000409 assay measurement type http://www.bioassayontology.org/bao#BAO_0000026 bioassay specification This describes whether a change in an assay is measured once at one fixed end-point or over a period of time at several time points. http://www.bioassayontology.org/bao#BAO_0000415 immunohistochemistry http://www.bioassayontology.org/bao#BAO_0000128 in situ immunoassay This technique is used to detect proteins and peptides in a tissue section by binding to specific antibodies. Subsequently, a secondary antibody that is conjugated to a fluorophore or an enzyme needed for the detection of a signal is hybridized to the primary antibody. Signal is generally detected by immunofluorescence or less commonly, by a colored reaction. This allows the detection and subcellular localization of the protein of interest by visualization under a microscope. http://www.bioassayontology.org/bao#BAO_0000416 immunocytochemistry http://www.bioassayontology.org/bao#BAO_0000128 in situ immunoassay This technique is used to detect proteins and peptides in a cell by binding to specific antibodies. Subsequently, a secondary antibody that is conjugated to a fluorophore or an enzyme needed for the detection of a signal is hybridized to the primary antibody. Signal is generally detected by immunofluorescence or less commonly, by a colored reaction. This allows the detection and subcellular localization of the protein of interest by visualization under a microscope. http://www.bioassayontology.org/bao#BAO_0000423 mitochondrial membrane potential assessment http://www.bioassayontology.org/bao#BAO_0000127 viability measurement method Activity of the mitochondrial respiratory chain results in the generation of a proton gradient which consists of two components: a membrane potential and a pH gradient. Disruption of delta-psi has been shown to be one of the first intracellular changes following the onset of apoptosis. Delta-psi is generally quantitated by staining with specific dyes whose binding is dependent on the potential and less commonly, by electrophysiological techniques. http://www.bioassayontology.org/bao#BAO_0000425 dye binding method http://www.bioassayontology.org/bao#BAO_0000377 membrane potential measurement method Most often, the mitochondrial membrane potential which is called delta-psi is quantitated by staining with specific dyes whose binding is dependent on the potential. http://www.bioassayontology.org/bao#BAO_0000427 label free method http://www.bioassayontology.org/bao#BAO_0000035 physical detection method It allows the detection of binding interactions and cell-based reactions without the need to use conventional labels, e.g., fluorescent probes. The advantages include the ability to measure a) functional activity without modifying the binding partners with labels, b) binding interactions independent of functional activity, and c) cell-Based GPCR assays without the need for engineering cell-lines to over-express given receptors. http://www.bioassayontology.org/bao#BAO_0000430 B-score http://www.bioassayontology.org/bao#BAO_0002126 statistical endpoint The B score is an analog of the Z score, but is more resistant to the presence of outliers and to differences in the measurement error distributions of the compounds. It is calculated by first computing a two-way median to account for row and column effects of the plate, which is then divided by their median absolute deviation to standardize for plate-to-plate variability. http://www.bioassayontology.org/bao#BAO_0000433 curve fit method http://www.bioassayontology.org/bao#BAO_0002754 assay data processing method Curve fit methods include Levenberg-Marquardt, Simplex, Linear Regression (linear least-squares), etc. The Levenberg-Marquardt method is a robust algorithm and has become the standard for non-linear regression. http://www.bioassayontology.org/bao#BAO_0000434 curve fit specification http://www.bioassayontology.org/bao#BAO_0003115 assay result component Has curve fit parameters, curve fit method, properties like Hill coefficient, concentration range, and measurement repetition. It involves capturing the trend in the data by assigning a single function across the entire range. The goal of curve fitting is to find the parameter values that most closely match the data. http://www.bioassayontology.org/bao#BAO_0000441 competitive binding http://www.bioassayontology.org/bao#BAO_0000476 ligand binding mode of action An assay based on the competition between a labeled and an unlabeled ligand in the reaction with a receptor binding agent (e.g. antibody, receptor, transport protein). http://www.bioassayontology.org/bao#BAO_0000442 non-competitive binding http://www.bioassayontology.org/bao#BAO_0000476 ligand binding mode of action Non-competitive ligands interact with receptors at sites distinct from the competitive ligand binding pocket, conferring multiple modes of action. http://www.bioassayontology.org/bao#BAO_0000443 input data http://www.bioassayontology.org/bao#BAO_0000434 curve fit specification It identifies whether the data has been normalized (by Z and Z' factors, signal to background, signal to noise, and coefficient of variance), or if it was an immediate readout obtained from a HTS assay. http://www.bioassayontology.org/bao#BAO_0000444 normalized data http://www.bioassayontology.org/bao#BAO_0000443 input data Data can be normalized by Z and Z' factors, signal to background, signal to noise, and coefficient of variance. Plate based normalization is usually based on controls. In the absence of controls, the Z-score can be used to normalize the data by plate. http://www.bioassayontology.org/bao#BAO_0000445 raw data http://www.bioassayontology.org/bao#BAO_0000443 input data The readout obtained from a HTS assay which includes measurements from the positive and negative control wells in each plate. This is the data that needs to be processed. http://www.bioassayontology.org/bao#BAO_0000451 optical microscopy http://www.bioassayontology.org/bao#BAO_0002526 microscopy Optical or light microscopy involves passing visible light transmitted through or reflected from the sample through a single or multiple lenses to allow a magnified view of the sample http://www.bioassayontology.org/bao#BAO_0000452 imaging method http://www.bioassayontology.org/bao#BAO_0000035 physical detection method The field of using microscopes to see objects that cannot be seen with the unaided eye. http://www.bioassayontology.org/bao#BAO_0000453 confocal microscopy http://www.bioassayontology.org/bao#BAO_0000451 optical microscopy Confocal microscopy has advantages over widefield optical microscopy, including the ability to eliminate or reduce background information away from the focal plane and collect serial optical sections from thick specimens. It uses point illumination and a spatial pinhole to eliminate out-of-focus light in specimens that are thicker than the focal plane. http://www.bioassayontology.org/bao#BAO_0000458 phase contrast microscopy http://www.bioassayontology.org/bao#BAO_0000451 optical microscopy Phase contrast microscopy shows differences in refractive index as difference in contrast. Regions with higher contrast, e.g. nuclei, appear darker than the surrounding cytoplasm. http://www.bioassayontology.org/bao#BAO_0000459 scanning probe microscopy http://www.bioassayontology.org/bao#BAO_0002526 microscopy It forms images of surfaces using a physical probe that scans the specimen and measuring on a fine scale, down to the level of molecules and groups of atoms. The resolution is not limited by the diffraction, but by the size of probe-sample interaction volume. Atomic force microscopy (AFM), scanning tunneling microscopy (STM), and near-field scanning optical microscopy (NSOM) are the three common scanning probe techniques. http://www.bioassayontology.org/bao#BAO_0000466 ex situ immunoassay http://www.bioassayontology.org/bao#BAO_0000129 immunoassay Ex situ refers to out of place or position, with respect to the antigen that is being tested in the immunoassay. Usually the antigen is present in a tissue or cell lysate, or as a purified protein in the assay. http://www.bioassayontology.org/bao#BAO_0000467 alternate assay format http://www.bioassayontology.org/bao#BAO_0000806 alternate confirmatory assay This assay is performed using a different assay format with respect to the primary or confirmatory assay. http://www.bioassayontology.org/bao#BAO_0000468 signal quantitation method http://www.bioassayontology.org/bao#BAO_0002429 assay supporting method A digital system used for quantitating proteins in gels, blots, etc. http://www.bioassayontology.org/bao#BAO_0000469 nucleic acid conformation assessment http://www.bioassayontology.org/bao#BAO_0000048 conformation determination method This technology relates to measurement of nucleic acid conformational properties using one of the following methods: circular dichroism spectroscopy, thermal shift, fluorescence resonance energy transfer (FRET), nuclear magnetic resonance (NMR), X-ray crystallography, etc. http://www.bioassayontology.org/bao#BAO_0000470 protein conformation assessment http://www.bioassayontology.org/bao#BAO_0000048 conformation determination method This technology relates to measurement of protein conformational properties using one of the following methods: circular dichroism spectroscopy, thermal shift, fluorescence resonance energy transfer (FRET), nuclear magnetic resonance (NMR), X-ray crystallography, etc. http://www.bioassayontology.org/bao#BAO_0000471 carbon nanotube based sensor http://www.bioassayontology.org/bao#BAO_0000163 electrical sensor Carbon nanotubes (CNT) are rolled up seamless cylinders of graphene sheets, exhibiting many unique physical, mechanical and chemical properties. CNT based biosensors are used to detect protein interactions, e.g. protein-DNA, antibody-aptamer interaction, etc. http://www.bioassayontology.org/bao#BAO_0000473 small molecule array http://www.bioassayontology.org/bao#BAO_0000514 array Small molecules which are either natural or synthetic are immobilized by robotic printing on a solid support, such as a functionalized glass slide. Protein targets either purified or from a lysate are hybridized to the immobilized small molecules in an attempt to identify the natural ligands for proteins, and also molecules that could regulate their function. http://www.bioassayontology.org/bao#BAO_0000474 lysate array http://www.bioassayontology.org/bao#BAO_0000505 protein array This contains complex samples, such as cell or tissue lysates, spotted on an array surface and interrogated with antibodies. http://www.bioassayontology.org/bao#BAO_0000476 ligand binding mode of action http://www.bioassayontology.org/bao#BAO_0000074 mode of action Concepts describing the type of perturbagen interaction with the receptor. http://www.bioassayontology.org/bao#BAO_0000477 km http://www.bioassayontology.org/bao#BAO_0000487 enzyme kinetic constant The concentration of substrate at ½ Vmax, according to the Henri-Michaelis-Menten kinetic model. http://www.bioassayontology.org/bao#BAO_0000480 kon http://www.bioassayontology.org/bao#BAO_0000487 enzyme kinetic constant The on-rate associated with the formation of an enzyme-inhibitor complex. http://www.bioassayontology.org/bao#BAO_0000481 kcat http://www.bioassayontology.org/bao#BAO_0000487 enzyme kinetic constant Turnover number representing the maximum number of substrate molecules converted to products per active site per unit time. http://www.bioassayontology.org/bao#BAO_0000482 competitive inhibition http://www.bioassayontology.org/bao#BAO_0000091 inhibition A competitive inhibitor binds only to free enzyme. Often this binding event occurs on the active site of the target, precisely where substrate also binds. It will raise the apparent KM value for its substrate with no change in the apparent Vmax value. As a result, competitive inhibition can be overcome, observed by an increase in the apparent KI value, at higher concentrations of substrate. http://www.bioassayontology.org/bao#BAO_0000483 uncompetitive inhibition http://www.bioassayontology.org/bao#BAO_0000091 inhibition An uncompetitive inhibitor binds exclusively to the enzyme-substrate complex yielding an inactive enzyme-substrate-inhibitor complex. When encountered, the apparent Vmax value and the apparent KM value should both decrease. http://www.bioassayontology.org/bao#BAO_0000485 non-competitive inhibition http://www.bioassayontology.org/bao#BAO_0000091 inhibition A noncompetitive inhibitor binds equally well to both free enzyme and the enzyme-substrate complex. These binding events occur exclusively at a site distinct from the precise active site occupied by substrate. It will lower the apparent Vmax value, yet there is no effect on the apparent KM value for its substrate. Essentially, the KI of the inhibitor does not change as a function of the substrate concentration. http://www.bioassayontology.org/bao#BAO_0000487 enzyme kinetic constant http://www.bioassayontology.org/bao#BAO_0000016 protein substrate and ligand constant Describe kinetics of enzyme-catalyzed reactions. It includes the enzyme kinetic constants namely, Km and Vmax, which help to model the time course of disappearance of substrate and the production of product. http://www.bioassayontology.org/bao#BAO_0000488 partial inhibition http://www.bioassayontology.org/bao#BAO_0000091 inhibition Partial inhibition results from the formation of an enzyme-substrate-inhibitor complex that can generate product with less efficiency than the enzyme-substrate complex. http://www.bioassayontology.org/bao#BAO_0000489 allosteric modulation http://www.bioassayontology.org/bao#BAO_0002909 modulation An allosteric effector operates to enhance active site substrate affinity and/or catalysis. An allosteric inhibitor decreases activity by binding to an allosteric site, other than or in addition to the active site on the target. This interaction is characterized by a conformational change in the target enzyme that is required for inhibition. http://www.bioassayontology.org/bao#BAO_0000490 tight binding inhibition http://www.bioassayontology.org/bao#BAO_0000091 inhibition In this type of inhibition, the population of free, soluble inhibitor is significantly depleted by the formation of the enzyme-inhibitor or enzyme-substrate-inhibitor complex. While tight-binding inhibitors can bind to the target enzyme in a competitive, noncompetitive, or uncompetitive manner with respect to substrate binding, they can display noncompetitive phenotypes. http://www.bioassayontology.org/bao#BAO_0000491 time dependent inhibition http://www.bioassayontology.org/bao#BAO_0000091 inhibition Time-dependent inhibitors bind slowly to the enzyme on the time scale of enzymatic turnover, and thus display a change in initial velocity with time. This has the effect of slowing the observed onset of inhibition. http://www.bioassayontology.org/bao#BAO_0000492 analytical array http://www.bioassayontology.org/bao#BAO_0000505 protein array In this method, antibodies or peptides are spotted on a support to be hybridized to analytes in complex mixtures of proteins. http://www.bioassayontology.org/bao#BAO_0000497 peptide aptamer http://www.bioassayontology.org/bao#BAO_0003043 molecular entity Aptamers are synthetic affinity probes. Peptide aptamers consist of a variable peptide loop attached at both ends of a protein scaffold, such as thioredoxin-A. They bind to target proteins with high affinity, similar to that of an antibody. They are designed to inhibit the function of other protein inside the cell. http://www.bioassayontology.org/bao#BAO_0000498 riboswitch http://www.bioassayontology.org/bao#BAO_0000270 RNA They are part of mRNA that regulate gene expression through ligand induced changes in mRNA secondary or tertiary structure. The ligand is generally a small metabolite which binds to the aptamer part of the riboswitch. http://www.bioassayontology.org/bao#BAO_0000499 cell movement measurement method http://www.bioassayontology.org/bao#BAO_0002202 assay design method The technologies used to measure the movement of cells and organelles (phenotype). These are detected by microscopy. http://www.bioassayontology.org/bao#BAO_0000500 molecular beacon http://www.bioassayontology.org/bao#BAO_0003043 molecular entity Molecular beacons are hairpin shaped oligonucleotide probes with an internally quenched fluorophore whose fluorescence is restored upon binding to a target nucleic acid. They are used to detect nucleic acids in solution. http://www.bioassayontology.org/bao#BAO_0000501 purified protein array http://www.bioassayontology.org/bao#BAO_0000505 protein array In this method, many different purified proteins are spotted on a support, and used to assay biochemical functions such as protein-protein, protein-DNA, protein-small molecule interactions and enzyme activity. http://www.bioassayontology.org/bao#BAO_0000502 antibody http://www.bioassayontology.org/bao#BAO_0002554 protein complex Antibody is a protein (immunoglobulin) produced by the immune system of an organism in response to exposure to a foreign molecule (antigen) and characterized by its specific binding to a site of that molecule (antigenic determinant or epitope). Antibodies are used extensively as tools to characterize proteins. Antibodies are either monoclonal or polyclonal. http://www.bioassayontology.org/bao#BAO_0000503 monoclonal http://www.bioassayontology.org/bao#BAO_0000502 antibody Highly specific antibodies produced by the clones of a single hybrid cell, which is generated by the fusion of a B cell with a tumor cell. They recognize a unique epitope of an antigen. http://www.bioassayontology.org/bao#BAO_0000504 nucleic acid array http://www.bioassayontology.org/bao#BAO_0000514 array Nucleic acids, either DNA or RNA are immobilized by spotting on a solid support such as a glass slide. They are hybridized with labeled nucleic acids from a sample and the signals measured, which reflects the composition of the sample nucleic acids. This is performed to quantify gene expression under various situations, e.g. diseases, development, etc. http://www.bioassayontology.org/bao#BAO_0000505 protein array http://www.bioassayontology.org/bao#BAO_0000514 array This includes spotting purified proteins, cell or tissue lysates, antibodies, or peptides in order to quantify the proteome, or study protein-protein, protein-DNA, protein-small molecule interactions and enzyme activity. http://www.bioassayontology.org/bao#BAO_0000507 polyclonal http://www.bioassayontology.org/bao#BAO_0000502 antibody Antibodies produced by immunizing a mammal such as a mouse, rabbit or goat with an antigen. They are a mixture of antibodies produced from different B cells raised against any of the different epitopes of that antigen. http://www.bioassayontology.org/bao#BAO_0000509 eukaryote http://www.bioassayontology.org/bao#BAO_0000658 cellular organisms This includes fungi, vertebrates and invertebrates. Eukaryotic cells have a well-defined nucleus and membrane enveloped organelles namely, mitochondria, endoplasmic reticulum, golgi apparatus, and lysosomes. http://www.bioassayontology.org/bao#BAO_0000510 vertebrate http://www.bioassayontology.org/bao#BAO_0000659 metazoa This includes animals having a vertebral column, and model organisms from this group include the zebrafish, mouse, rat, etc http://www.bioassayontology.org/bao#BAO_0000512 assay footprint http://www.bioassayontology.org/bao#BAO_0000026 bioassay specification This describes the physical format such as plate density in which an assay is performed, which is generally a microplate format, but can also be an array format. http://www.bioassayontology.org/bao#BAO_0000514 array http://www.bioassayontology.org/bao#BAO_0000512 assay footprint The immobilization of thousands of small molecules, genes or proteins on a glass slide for performing binding studies. http://www.bioassayontology.org/bao#BAO_0000517 summary assay http://www.bioassayontology.org/bao#BAO_0000029 assay screening campaign stage It is a PubChem-specific assay stage. A summary assay references and summarizes the assays in PubChem that correspond to a screening campaign or a probe development project. http://www.bioassayontology.org/bao#BAO_0000519 signal direction http://www.bioassayontology.org/bao#BAO_0003115 assay result component It is the trend of measured readout signal, whether it increases or decreases in perturbagen treated wells, as compared to the untreated or carrier-treated wells and the endpoint mode of action of an assay. http://www.bioassayontology.org/bao#BAO_0000520 assay description http://www.bioassayontology.org/bao#BAO_0002933 experimental specification This includes the different pieces of information about a PubChem bioassay that is available at the PubChem website, namely, the assay title, assay protocol, assay description, assay provider, endpoint name, etc. http://www.bioassayontology.org/bao#BAO_0000521 assay title http://www.bioassayontology.org/bao#BAO_0000520 assay description The name of a bioassay which is associated with each assay ID (AID). It contains information about the target tested, the stage of the assay (primary or confirmatory), the assay format (biochemical or cell based), etc. http://www.bioassayontology.org/bao#BAO_0000522 assay narrative http://www.bioassayontology.org/bao#BAO_0000520 assay description This contains the background information and rationale for performing a bioassay and is found on the PubChem website associated with each assay ID (AID). It also includes the assay design and some information on the related bioassays. http://www.bioassayontology.org/bao#BAO_0000523 assay protocol http://www.bioassayontology.org/bao#BAO_0000520 assay description This includes the methodology used to perform a particular bioassay and is found on the PubChem website associated with each assay ID (AID). It includes the assay components and the order in which they were added, the incubation times, detection method and the kit used, etc. http://www.bioassayontology.org/bao#BAO_0000524 assay depositor http://www.bioassayontology.org/bao#BAO_0002900 researcher role The role of an organization or individual to add an assay to a repository, such as PubChem. http://www.bioassayontology.org/bao#BAO_0000525 assay comment http://www.bioassayontology.org/bao#BAO_0000520 assay description This is the PubChem assay remark that can be assigned by depositors to a bioassay. http://www.bioassayontology.org/bao#BAO_0000529 signal window http://www.bioassayontology.org/bao#BAO_0000028 assay quality assessment method Difference of signal between positive and negative controls; assay dynamic range: SW={Avg(poscontrol)-Avg(negcontrol)-3x[StdDev(poscontrol)+StdDev(negcontrol)]}/StdDev(poscontrol). http://www.bioassayontology.org/bao#BAO_0000530 signal to noise http://www.bioassayontology.org/bao#BAO_0000028 assay quality assessment method Measure of signal strength. S/N=[Avg(poscontrol)-Avg(negcontrol)]/[StdDev(poscontrol)+StdDev(negcontrol)] http://www.bioassayontology.org/bao#BAO_0000531 coefficient of variation http://www.bioassayontology.org/bao#BAO_0000028 assay quality assessment method Measure of the signal dispersion: CV=100x[StdDev(sample)/Avg(sample)] http://www.bioassayontology.org/bao#BAO_0000532 assay measurement throughput http://www.bioassayontology.org/bao#BAO_0000026 bioassay specification Assay measurements throughput quality describes the quality of the measurements performed on each sample, such as single concentration, single repetition, concentration-response, multiple repetitions, etc. http://www.bioassayontology.org/bao#BAO_0000536 single concentration http://www.bioassayontology.org/bao#BAO_0002177 concentration throughput Multiple measurements (typically three) are preformed at a single concentration. This is often used as a mode of confirmatory screening following a primary screen. http://www.bioassayontology.org/bao#BAO_0000545 recombinant virus transduction method http://www.bioassayontology.org/bao#BAO_0002155 silencing RNA delivery method This refers to the infection of cells with a modified virus, which introduces viral genome containing the foreign genes. Several types of viruses are utilized for recombinant gene expression, including lentivirus, retrovirus, adenovirus, etc, with each having their own advantages and disadvantages. http://www.bioassayontology.org/bao#BAO_0000546 pathogenic virus transduction method http://www.bioassayontology.org/bao#BAO_0000244 viral transduction method This refers to the infection of cells with a disease-causing virus, which could effect humans, animals and plants. Pathogenic viruses include the influenza virus, measles virus, Japanese encephalitis virus, etc. http://www.bioassayontology.org/bao#BAO_0000547 bacterial infection method http://www.bioassayontology.org/bao#BAO_0000238 cell line modification method It is a live cell assay in which eukaryotic cells are infected with bacteria. http://www.bioassayontology.org/bao#BAO_0000551 organism http://www.bioassayontology.org/bao#BAO_0003114 assay biology component The organism related to the target / meta-target of the bioassay. It includes both bacterium and eukaryote. http://www.bioassayontology.org/bao#BAO_0000558 manufacturer role http://www.bioassayontology.org/bao#BAO_0002590 organization role The role of an individual or a company as a creator of an assay kit, compound library, or detection instrument. http://www.bioassayontology.org/bao#BAO_0000562 assay readout content parametricity http://www.bioassayontology.org/bao#BAO_0000026 bioassay specification This describes the throughput and information content generated. Categorizing multiplexed (i.e. mutiple targets measured simultaneously) and multiparametric assays and high content (image-based) and regular (plate reader) assays. http://www.bioassayontology.org/bao#BAO_0000563 single parameter readout http://www.bioassayontology.org/bao#BAO_0002185 measure group specification Typically uses a plate reader and generates one or two readouts, in contrast to high content screening or multiplexed assays, which can generate tens to hundreds of parameters. The readout is typically from a single target / meta-target in each well. http://www.bioassayontology.org/bao#BAO_0000565 wavelength http://purl.obolibrary.org/obo/PATO_0001018 physical quality A physical quality which is equal to the distance between repeating units of a wave pattern (from PATO). For fluorescence measurements, it is the wavelength at which the fluorophore is excited and the wavelength at which it emits fluorescence. In the case of absorbance, it is the wavelength at which light is absorbed by a biological entity or a dye. http://www.bioassayontology.org/bao#BAO_0000566 excitation wavelength http://www.bioassayontology.org/bao#BAO_0000565 wavelength For fluorescence measurements, it is the wavelength at which a fluorophore is excited http://www.bioassayontology.org/bao#BAO_0000568 absorbance wavelength http://www.bioassayontology.org/bao#BAO_0000565 wavelength In absorbance measurements, it is the wavelength at which light is absorbed by a biological entity or a dye http://www.bioassayontology.org/bao#BAO_0000570 partially purified http://www.bioassayontology.org/bao#BAO_0002619 categorical purity The protein is only partially purified http://www.bioassayontology.org/bao#BAO_0000572 cell number determination http://www.bioassayontology.org/bao#BAO_0000127 viability measurement method Cells are counted to determine their viability. Cultured animal cells are counted either manually using hemocytometer, or by an automated cell counter, e.g. Coulter counter or Vi-CELL. The latter can distinguish live and dead cells by the trypan blue cell exclusion method. Yeast and bacterial cell growth is determined by measuring absorbance in a spectrophotometer, or by viable plate count. http://www.bioassayontology.org/bao#BAO_0000573 perturbagen delivery method http://www.bioassayontology.org/bao#BAO_0002198 delivery method This describes whether the perturbagens are tested individually or as mixtures / pools http://www.bioassayontology.org/bao#BAO_0000574 single perturbagen http://www.bioassayontology.org/bao#BAO_0000573 perturbagen delivery method The perturbagens are tested individually in an assay http://www.bioassayontology.org/bao#BAO_0000575 mixture of perturbagens http://www.bioassayontology.org/bao#BAO_0000573 perturbagen delivery method Mixtures / pools of perturbagens are tested in an assay http://www.bioassayontology.org/bao#BAO_0000578 cuvette http://www.bioassayontology.org/bao#BAO_0000512 assay footprint Cuvettes are used to measure absorbance or fluorescence in a spectrophotometer or fluorimeter, respectively using either plastic, glass or quartz cuvettes. http://www.bioassayontology.org/bao#BAO_0000583 raw activity http://www.bioassayontology.org/bao#BAO_0000181 response endpoint Raw or qualitative data are reported as endpoints in an assay, e.g., luminescence counts, fluorescence intensity, etc. http://www.bioassayontology.org/bao#BAO_0000585 temperature endpoint http://www.bioassayontology.org/bao#BAO_0000179 endpoint The types of endpoints that report changes in temperature as a measure of a biological reaction, e.g. tm. http://www.bioassayontology.org/bao#BAO_0000586 vmax http://www.bioassayontology.org/bao#BAO_0000487 enzyme kinetic constant Vmax is defined as the maximum initial velocity of an enzyme catalyzed reaction under the given conditions, and it is measured in units of quantity of substrate transformed per unit time for a given concentration of enzyme. http://www.bioassayontology.org/bao#BAO_0000587 binding constant http://www.bioassayontology.org/bao#BAO_0000016 protein substrate and ligand constant This endpoint type describes the bonding affinity between two molecules at equilibrium, e.g., drug-receptor interaction. http://www.bioassayontology.org/bao#BAO_0000596 assay medium http://www.bioassayontology.org/bao#BAO_0003116 material entity The cell culture broth used while performing an assay on cells, which is optimized for each assay type. Some interfering additives such as serum, growth factors, buffers, amino acids, antibiotics, etc. might be eliminated in this medium. http://www.bioassayontology.org/bao#BAO_0000610 PubChem endpoint name http://www.bioassayontology.org/bao#BAO_0003115 assay result component It is the term that describes an endpoint or result of a bioassay, which is deposited at PubChem. http://www.bioassayontology.org/bao#BAO_0000612 assay repository http://www.bioassayontology.org/bao#BAO_0002933 experimental specification It is the repository (database) in which the assay was deposited, e.g., PubChem, ChEMBL, etc. http://www.bioassayontology.org/bao#BAO_0000613 PubChem http://www.bioassayontology.org/bao#BAO_0000612 assay repository PubChem (http://pubchem.ncbi.nlm.nih.gov) is a public database that contains high throughput screening (HTS) data, where the assays are performed to identify small molecules effective at modulating a given biological process or disease state. The bioactivity results in PubChem are contributed by several organizations, with the majority of data coming from the screening center network under the NIH Molecular Libraries Program (MLP). http://www.bioassayontology.org/bao#BAO_0000614 ChEMBL http://www.bioassayontology.org/bao#BAO_0000612 assay repository It is a public database that contains structure http://www.bioassayontology.org/bao#BAO_0000615 PDSP http://www.bioassayontology.org/bao#BAO_0000612 assay repository It is a public database that contains screening data of novel psychoactive compounds for pharmacological and functional activity. http://www.bioassayontology.org/bao#BAO_0000623 compound toxicity assay http://www.bioassayontology.org/bao#BAO_0000803 counter screening assay This assay is performed to identify compounds that have an ability to kill the cells (cytotoxic). http://www.bioassayontology.org/bao#BAO_0000625 curve fit model http://www.bioassayontology.org/bao#BAO_0000434 curve fit specification A mathematical model / equation to which the data is fitted (using the curve fit method / algorithm). http://www.bioassayontology.org/bao#BAO_0000641 inserted http://www.bioassayontology.org/bao#BAO_0000643 mutated A quality of the genetic material (DNA or RNA) that harbors a change (mutation), where one or more nucleotides are added either spontaneously (within the cell) or intentionally (experimentally). http://www.bioassayontology.org/bao#BAO_0000642 point mutated http://www.bioassayontology.org/bao#BAO_0000643 mutated A quality of the genetic material (DNA or RNA) that harbors a change (mutation), where one nucleotide is replaced by a different nucleotide either spontaneously (within the cell) or intentionally (experimentally). http://www.bioassayontology.org/bao#BAO_0000644 truncated http://www.bioassayontology.org/bao#BAO_0000643 mutated A quality of a protein that harbors a change (mutation), where a portion of the protein towards the carboxyl-terminal is missing either spontaneously (within the cell) or intentionally (experimentally). http://www.bioassayontology.org/bao#BAO_0000647 parental cell line assay http://www.bioassayontology.org/bao#BAO_0000803 counter screening assay This assay is performed with the unmodified or parental cell line instead of the one modified with a DNA construct that was used in primary or confirmatory assays. http://www.bioassayontology.org/bao#BAO_0000648 compound library http://www.bioassayontology.org/bao#BAO_0000661 perturbagen library The name of a small molecule collection from one source, which can be either commercial or academic, e.g., MLSMR, LOPAC, etc. This collection is generally diverse and contains compounds that modulate diverse biological targets. http://www.bioassayontology.org/bao#BAO_0000649 calcium redistribution assay http://www.bioassayontology.org/bao#BAO_0000819 ion redistribution assay Calcium functions as second messenger in cell signaling. http://www.bioassayontology.org/bao#BAO_0000652 protease http://www.bioassayontology.org/bao#BAO_0000287 hydrolase A protease is an enzyme that hydrolyzes the peptide bonds in a protein or a peptide. http://www.bioassayontology.org/bao#BAO_0000653 dye redistribution assay http://www.bioassayontology.org/bao#BAO_0002999 redistribution assay Dye redistribution is used to study flux of molecules across membranes, e.g. calcein AM, ethidium homodimer-1, etc. http://www.bioassayontology.org/bao#BAO_0000657 radiometry method http://www.bioassayontology.org/bao#BAO_0000035 physical detection method Detection technology using radioactive tracers, e.g. filter assay, SPA, etc http://www.bioassayontology.org/bao#BAO_0000658 cellular organisms http://www.bioassayontology.org/bao#BAO_0000551 organism This includes all organisms which are made up of cells, e.g. bacteria, plants and animals. http://www.bioassayontology.org/bao#BAO_0000659 metazoa http://www.bioassayontology.org/bao#BAO_0000509 eukaryote Metazoa comprises of animals, which are multicellular eukaryotic organisms. This includes those having a vertebral column (e.g. fish, frog, snake, bird, human) and those that do not (e.g. worm, fly, star fish, etc). http://www.bioassayontology.org/bao#BAO_0000661 perturbagen library http://www.bioassayontology.org/bao#BAO_0003120 assay screened entity component It is a collection of perturbagens, e.g., compound, siRNA, miRNA, etc, which are sold by different vendors, or generated in academic institutions. http://www.bioassayontology.org/bao#BAO_0000666 metal salt http://www.bioassayontology.org/bao#BAO_0003043 molecular entity An ionic compound (principally consisting of Na, K, Li, Ca, and Mg as cation) which is used as an additive in an assay. http://www.bioassayontology.org/bao#BAO_0000673 amino acid substituted http://www.bioassayontology.org/bao#BAO_0000643 mutated A quality of a protein that harbors a change (mutation), where either one or more amino acids are replaced by different ones to study the role of those amino acids in the function of the protein. http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0003118 instrument The names of equipment used for measurement/readout from an assay, e.g. FLIPR, ViewLux plate reader, PHERAstar, etc. http://www.bioassayontology.org/bao#BAO_0000709 research institute http://www.bioassayontology.org/bao#BAO_0002934 organization The name of the screening center organization that is affiliated with an assay or an experiment; for example the assay was developed by an individual affiliated with that organization or an assay experiment (screen) was performed by a group / in lab affiliated with that research organization. http://www.bioassayontology.org/bao#BAO_0000710 vanderbilt screening center for gpcrs, ion channels and transporters http://www.bioassayontology.org/bao#BAO_0000709 research institute It is a specialized chemistry center of MLPCN. http://www.bioassayontology.org/bao#BAO_0000791 southern research institute http://www.bioassayontology.org/bao#BAO_0000709 research institute It is a specialized screening center of MLPCN. http://www.bioassayontology.org/bao#BAO_0000803 counter screening assay http://www.bioassayontology.org/bao#BAO_0000032 secondary assay An assay run to eliminate those hits from the primary and confirmatory assay stages that are not of interest, i.e. do not act via the MMOA of interest; for example compounds that are assay artifacts (e.g. fluorescent), promiscuously active, toxic. http://www.bioassayontology.org/bao#BAO_0000804 maximal inhibition http://www.bioassayontology.org/bao#BAO_0000656 efficacy Maximum inhibition of an antagonist or inhibitor (relative an efficacious positive control) http://www.bioassayontology.org/bao#BAO_0000805 maximal activation http://www.bioassayontology.org/bao#BAO_0000656 efficacy The maximum percent activation of an agonist http://www.bioassayontology.org/bao#BAO_0000806 alternate confirmatory assay http://www.bioassayontology.org/bao#BAO_0000032 secondary assay An assay using orthogonal assay design / technology run to confirm the identified hits from the primary and confirmatory assay stages. http://www.bioassayontology.org/bao#BAO_0000813 MLSCN center at columbia university http://www.bioassayontology.org/bao#BAO_0000709 research institute It is an MLSCN (pilot phase) screening center. http://www.bioassayontology.org/bao#BAO_0000818 biological ligand http://purl.obolibrary.org/obo/CHEBI_24432 biological role The role played by a soluble molecule, such as a hormone, neurotransmitter, or small molecule that binds to a biomolecular entity, such as a receptor. http://www.bioassayontology.org/bao#BAO_0000819 ion redistribution assay http://www.bioassayontology.org/bao#BAO_0002999 redistribution assay Radiolabeled flux assays to study ion channel activity by chemically initiating the opening of channels in the presence of a fixed amount of radiolabeled cation or anion, and a potential ion channel modulator compound. http://www.bioassayontology.org/bao#BAO_0000834 Ac-DEVD-CHO http://www.bioassayontology.org/bao#BAO_0000325 peptide Ac-DEVD-CHO is an inhibitor of caspase-3/7 (DEVDase) activity. http://www.bioassayontology.org/bao#BAO_0000862 bisindolylmaleimide http://www.bioassayontology.org/bao#BAO_0003043 molecular entity PKC inhibitor 3-{1-[3-(dimethylamino)propyl]-1H-indol-3-yl}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione http://www.bioassayontology.org/bao#BAO_0000885 cysteine http://www.bioassayontology.org/bao#BAO_0003043 molecular entity Cysteine has antioxidant properties due to the ability of thiols to undergo redox reactions. http://www.bioassayontology.org/bao#BAO_0000891 diminazene aceturate http://www.bioassayontology.org/bao#BAO_0003043 molecular entity It intercalates DNA and RNA. http://www.bioassayontology.org/bao#BAO_0000895 DTT http://www.bioassayontology.org/bao#BAO_0003043 molecular entity Dithiothreitol (DTT) is the common name for a small-molecule redox reagent known as Cleland's reagent. DTT's formula is C4H10O2S2 and the molecular structure of its reduced form is shown at the right; its oxidized form is a disulfide-bonded 6-membered ring (shown below). Its name derives from the four-carbon sugar, threose. http://www.bioassayontology.org/bao#BAO_0000918 fMLFF peptide http://www.bioassayontology.org/bao#BAO_0000325 peptide fMLFF peptide is used as a FPR-blocking peptide. http://www.bioassayontology.org/bao#BAO_0000929 Go6976 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity 5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile Potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM). http://www.bioassayontology.org/bao#BAO_0000932 GW5074 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity 3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one Potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC50 = 9 nM). Displays ≥ 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. http://www.bioassayontology.org/bao#BAO_0000933 GW8510 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity An inhibitor of cyclin kinase 2 (CDK2) which prevents and/or reduces the side effects of chemotherapy (alopecia, plantar-palmar syndrome and mucositis). http://www.bioassayontology.org/bao#BAO_0000951 john hopkins ion channel center http://www.bioassayontology.org/bao#BAO_0000709 research institute It is a specialized screening center of MLPCN. http://www.bioassayontology.org/bao#BAO_0000952 L-AP4 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity L-(+)-2-Amino-4-phosphonobutyric acid Selective group III metabotropic glutamate receptor agonist. http://www.bioassayontology.org/bao#BAO_0000954 LDV peptide http://www.bioassayontology.org/bao#BAO_0000325 peptide LDV peptide targeted against the alpha4beta integrin VLA-4 http://www.bioassayontology.org/bao#BAO_0000956 lipofectamine 2000 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity Lipofectamine™ 2000 Reagent delivers DNA or siRNA with excellent transfection performance for protein expression, gene silencing, and functional assays. Superior efficiency, optimized protocols, and unparalleled success across a broad range of cell lines. http://www.bioassayontology.org/bao#BAO_0000989 the penn center for molecular discovery http://www.bioassayontology.org/bao#BAO_0000709 research institute It is an MLSCN (pilot phase) screening center. http://www.bioassayontology.org/bao#BAO_0000998 probenecid http://www.bioassayontology.org/bao#BAO_0003043 molecular entity 4-(Dipropylsulfamoyl)benzoic acid Inhibitor of multidrug resistance-associated proteins (MRP). http://www.bioassayontology.org/bao#BAO_0001003 pyrimidine-4,6-dicarboxylic acid http://www.bioassayontology.org/bao#BAO_0003043 molecular entity pyrimidine-4,6-dicarboxylic acid, bis-(4-fluoro-3-methyl-benzylamide) Degrades collagen type I. http://www.bioassayontology.org/bao#BAO_0001004 R18 peptide http://www.bioassayontology.org/bao#BAO_0000325 peptide The peptide sequence, PHCVPRDLSWLDLEANMCLP, named R18, was identified as an unphosphorylated peptide that binds to 14-3-3 proteins with high affinity (Kd=80 nM). It has been shown to bind to the same amphipathic groove on the surface of 14-3-3 as phosphorylated peptides. R18 can inhibit the formation of the 14-3-3-Raf-1 complex, reduce Raf-1 dependent transcriptional activity in cells and block the activation of ExoS by 14-3-3. It binds to all the 14-3-3 isoforms with equal affinities. This peptide is useful for competitive inhibition experiments. http://www.bioassayontology.org/bao#BAO_0001012 Ro 20-1724 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone Widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM). http://www.bioassayontology.org/bao#BAO_0001013 rolipram http://www.bioassayontology.org/bao#BAO_0003043 molecular entity Rolipram is a PDE4-inhibitor. http://www.bioassayontology.org/bao#BAO_0001018 sodium orthovanadate http://www.bioassayontology.org/bao#BAO_0003043 molecular entity Sodium orthovanadate is the chemical compound Na3VO4 and contains the tetrahedral VO43−. It is an inhibitor of protein tyrosine phosphatases, alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue. The VO43- ion binds reversibly to the active sites of most protein tyrosine phosphatases. http://www.bioassayontology.org/bao#BAO_0001021 staurosporine http://www.bioassayontology.org/bao#BAO_0003043 molecular entity Staurosporine (antibiotic AM-2282 or STS) is a natural product originally isolated in 1977 from the bacterium Streptomyces staurosporeus. http://www.bioassayontology.org/bao#BAO_0001022 stibavirin http://www.bioassayontology.org/bao#BAO_0003043 molecular entity The stibonic acid compound, NSC13778, also know as stibavirin, previously has been reported to inhibit the interaction between transcription factors C/EBP, C/EBPß, CREB, Fos/JunD, and VBP and their cognate DNA sequences, HIV nucleocapsid protein p7 and viral RNA, and HIV gp120 and CD4. Now, we report that this compound is a potent inhibitor of the interaction between transcription factors TFE3, Alveolar Soft Part Sarcoma (ASPS) associated fusion protein ASPL-TFE3 type 1, and ASPL-TFE3 type 2 and their cognate DNA. Proc Amer Assoc Cancer Res, Volume 47, 2006 http://www.bioassayontology.org/bao#BAO_0001027 TG003 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity 219479 Cdc2-Like Kinase Inhibitor, TG003 (Z)-1-(3-Ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene)propan-2-one, Clk Inhibitor, TG003 http://www.bioassayontology.org/bao#BAO_0001031 the scripps research institute molecular screening center http://www.bioassayontology.org/bao#BAO_0000709 research institute It is an MLPCN comprehensive screening center. http://www.bioassayontology.org/bao#BAO_0001032 thioflavine S http://www.bioassayontology.org/bao#BAO_0003043 molecular entity used for staining of senile amyloid deposits/plaques http://www.bioassayontology.org/bao#BAO_0001041 Ubiquitin vinyl sulfone http://www.bioassayontology.org/bao#BAO_0000365 cytosolic protein For use in the detection and identification of deubiquitinylating enzymes http://www.bioassayontology.org/bao#BAO_0001050 WIN55212 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity WIN 55,212-2 is a potent cannabinoid receptor agonist. http://www.bioassayontology.org/bao#BAO_0001064 alternate target assay http://www.bioassayontology.org/bao#BAO_0000803 counter screening assay This assay is performed with a different but a related target (usually from the same protein family) than that was tested in primary or confirmatory assays, e.g., SIP1 instead of SIP3. http://www.bioassayontology.org/bao#BAO_0001065 alternate cell line assay http://www.bioassayontology.org/bao#BAO_0000478 selectivity assay This assay is performed with a different cell line than that was tested in primary or confirmatory assays. http://www.bioassayontology.org/bao#BAO_0001066 alternate organism assay http://www.bioassayontology.org/bao#BAO_0000478 selectivity assay This assay is performed with a different organism than that was tested in primary or confirmatory assays. http://www.bioassayontology.org/bao#BAO_0001096 orthogonal assay technology http://www.bioassayontology.org/bao#BAO_0000806 alternate confirmatory assay This assay is performed using a different assay design or detection technology, e.g., a beta-lactamase assay performed using FRET technology instead of absorbance for measurement. http://www.bioassayontology.org/bao#BAO_0001097 alternate assay type http://www.bioassayontology.org/bao#BAO_0000806 alternate confirmatory assay This assay is a different bioassay type when compared to the primary or confirmatory assays, for e.g., a functional confirmatory assay (Ca-flux FLIPR), where the primary assay could be a binding assay. http://www.bioassayontology.org/bao#BAO_0001098 alternate assay conditions http://www.bioassayontology.org/bao#BAO_0000806 alternate confirmatory assay This assay is different from the primary or confirmatory assays with respect to the use of reagents / buffer, in order to narrow the mechanism of action of a perturbagen. http://www.bioassayontology.org/bao#BAO_0001099 compound fluorescence assay http://www.bioassayontology.org/bao#BAO_0000684 artifact assay This assay is performed to identify compounds that have a property of auto-fluorescence. http://www.bioassayontology.org/bao#BAO_0001100 compound aggregation assay http://www.bioassayontology.org/bao#BAO_0000684 artifact assay This assay is performed to identify compounds that have a propensity to aggregate. http://www.bioassayontology.org/bao#BAO_0001101 compound redox activity assay http://www.bioassayontology.org/bao#BAO_0000684 artifact assay This assay is performed to identify compounds with redox (reducing or oxidizing) activity. http://www.bioassayontology.org/bao#BAO_0001103 percent activity http://www.bioassayontology.org/bao#BAO_0000082 percent response Percent activity is the response relative to an unperturbed state; in case of inhibition the interpretation is that of remaining activity, i.e. percent inhibition := 100 - percent activity. http://www.bioassayontology.org/bao#BAO_0002006 percent apoptotic cells http://www.bioassayontology.org/bao#BAO_0000006 percent cytotoxicity The percentage of cells in an assay that show the hallmarks of 'programmed cell death' or apoptosis, namely, membrane asymmetry, caspase activation, nuclear fragmentation, etc. http://www.bioassayontology.org/bao#BAO_0002007 phosphorylated http://www.bioassayontology.org/bao#BAO_0000672 posttranslationally modified A quality of an amino acid residue that has a phosphate group attached to it. http://www.bioassayontology.org/bao#BAO_0002023 cytokine http://www.bioassayontology.org/bao#BAO_0000022 endogenous ligand The role played by a protein in modulating immune cell function via cell signaling, subsequent to binding to its cognate cell surface receptor. http://www.bioassayontology.org/bao#BAO_0002030 coupled substrate http://purl.obolibrary.org/obo/CHEBI_24432 biological role The role played by a molecular entity as being the substrate for a coupled enzyme (see definition of coupled enzyme). For e.g., luciferin, which is generated by cytochrome P450 (from modified luciferin) in a coupled enzyme reaction is the coupled substrate for luciferase. http://www.bioassayontology.org/bao#BAO_0002032 cell culture substrate http://purl.obolibrary.org/obo/CHEBI_24432 biological role The supportive role of a protein in mediating attachment of cells to a cell culture dish, on which it is coated. http://www.bioassayontology.org/bao#BAO_0002040 percent mitotic cells http://www.bioassayontology.org/bao#BAO_0001103 percent activity This represents the percentage of cells in a cell population that are in the M phase of the cell cycle. The cells in this phase can be detected using various markers, one of which is the characteristic phosphorylation of certain proteins that stain positive with MPM2 antibody. http://www.bioassayontology.org/bao#BAO_0002042 percent interphase cells http://www.bioassayontology.org/bao#BAO_0001103 percent activity This represents the percentage of cells in a cell population that are preparing for cell division and that exist in either G1, S or G2 phases of the cell cycle. This is calculated by subtracting from the total cell number, the number of cells in the M phase, apoptotic and dead cells in an assay plate. http://www.bioassayontology.org/bao#BAO_0002044 percent DNA replicated cells http://www.bioassayontology.org/bao#BAO_0001103 percent activity This represents the percentage of cells in a cell population that have undergone the S phase (completed DNA replication) in preparation for mitosis, as indicated by staining positive for EdU. http://www.bioassayontology.org/bao#BAO_0002046 percent dead cells http://www.bioassayontology.org/bao#BAO_0000006 percent cytotoxicity The percentage of cells in an assay that are no longer alive (viable), and show the characteristic features, such as staining with propidium iodide, blurry staining with DAPI, etc. http://www.bioassayontology.org/bao#BAO_0002057 engineered http://purl.obolibrary.org/obo/PATO_0001995 organismal quality The phenotype of an organism that has been derived by genetic modification. http://www.bioassayontology.org/bao#BAO_0002067 assay readout type http://www.bioassayontology.org/bao#BAO_0002185 measure group specification A physical parameter associated with an assay measurement. http://www.bioassayontology.org/bao#BAO_0002080 polymerase chain reaction http://www.bioassayontology.org/bao#BAO_0002450 nucleic acid amplification method In molecular biology, the polymerase chain reaction (PCR) is a technique to amplify a single or few copies of a piece of DNA across several orders of magnitude, generating thousands to millions of copies of a particular DNA sequence. The method relies on thermal cycling, consisting of cycles of repeated heating and cooling of the reaction for DNA melting and enzymatic replication of the DNA. Primers (short DNA fragments) containing sequences complementary to the target region along with a DNA polymerase (after which the method is named) are key components to enable selective and repeated amplification. As PCR progresses, the DNA generated is itself used as a template for replication, setting in motion a chain reaction in which the DNA template is exponentially amplified. http://www.bioassayontology.org/bao#BAO_0002081 percent G2 arrested cells http://www.bioassayontology.org/bao#BAO_0001103 percent activity This represents the percentage of cells in a cell population that have undergone the DNA synthesis in the S phase as indicated by staining positive for EdU, but have not undergone the M phase as they stained negative for MDM2. In other words, these cells were arrested in the G2/M cell cycle check-points after treatment with the respective perturbagen in the assay. http://www.bioassayontology.org/bao#BAO_0002082 percent non-arrested cells http://www.bioassayontology.org/bao#BAO_0001103 percent activity This represents the percentage of cells in a cell population that have completed the mitotic cell cycle, and that have stained positive for both S phase (EdU) and M phase (MDM2) markers. In other words, these cells were not arrested in any of the cell cycle check-points after treatment with the respective perturbagen in the assay. http://www.bioassayontology.org/bao#BAO_0002084 real-time PCR http://www.bioassayontology.org/bao#BAO_0002080 polymerase chain reaction In molecular biology, real-time polymerase chain reaction, also called quantitative real time polymerase chain reaction (Q-PCR/qPCR) or kinetic polymerase chain reaction, is a laboratory technique based on the PCR, which is used to amplify and simultaneously quantify a targeted DNA molecule. It enables both detection and quantification (as absolute number of copies or relative amount when normalized to DNA input or additional normalizing genes) of one or more specific sequences in a DNA sample. http://www.bioassayontology.org/bao#BAO_0002085 channel blocker http://purl.obolibrary.org/obo/CHEBI_51086 chemical role The role of a chemical entity to bind inside the pore of a specific type of ion channel and block the flow of ions through it, resulting in an alteration of the electrochemical gradient of the cell membrane. http://www.bioassayontology.org/bao#BAO_0002087 differentiation agent http://purl.obolibrary.org/obo/CHEBI_24432 biological role The molecular entity that brings about the transformation of less specialized cells to more specialized cell types, which differ morphologically and /or functionally. http://www.bioassayontology.org/bao#BAO_0002088 activator http://purl.obolibrary.org/obo/CHEBI_51086 chemical role The role of a molecular entity to bring about an increase of a predefined stimulus in an assay. http://www.bioassayontology.org/bao#BAO_0002089 reverse transcription PCR http://www.bioassayontology.org/bao#BAO_0002080 polymerase chain reaction Reverse transcription polymerase chain reaction (RT-PCR) is a variant of PCR in which the RNA strand is first reverse transcribed into its DNA complement (complementary DNA, or cDNA) using the enzyme reverse transcriptase, and the resulting cDNA is amplified using traditional or real-time PCR. http://www.bioassayontology.org/bao#BAO_0002090 quantitative reverse transcription PCR http://www.bioassayontology.org/bao#BAO_0002089 reverse transcription PCR Quantitative reverse transcription PCR is a PCR technique used to determine the amount of cDNA in a sample. It is the most commonly used form of quantitative PCR (qPCR). This technique is also called real-time reverse transcription PCR. http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0002934 organization The name of an organization that is involved in manufacture and / or commercialization of assay kits, detection instruments, small molecule libraries, etc. http://www.bioassayontology.org/bao#BAO_0002092 reference compound http://purl.obolibrary.org/obo/CHEBI_51086 chemical role The role of a small molecule to act as a standard in a particular assay type, e.g., 1,4-Dioxane (for NMR), Cediranib (for Kinomescan). http://www.bioassayontology.org/bao#BAO_0002093 carrier http://purl.obolibrary.org/obo/CHEBI_51086 chemical role Role of a protein in the transport of ions, small molecules, or macromolecules across a semi-permeable membrane, such as plasma membrane. http://www.bioassayontology.org/bao#BAO_0002094 computational method http://www.bioassayontology.org/bao#BAO_0002753 assay method component Method based on the application of information technology to chemistry and biology. http://www.bioassayontology.org/bao#BAO_0002095 bioinformatics method http://www.bioassayontology.org/bao#BAO_0002094 computational method Method based on application of information technology to the field of molecular biology. http://www.bioassayontology.org/bao#BAO_0002096 coupled enzyme http://purl.obolibrary.org/obo/CHEBI_24432 biological role The role played by an enzyme in reporting the activity of a different enzyme by being able to use the substrate or product of the latter in its own reaction (either as a substrate or cofactor). E.g., luciferase acts as a coupled enzyme for cytochrome P450, as the luciferin generated (from modified luciferin) by the latter acts as its substrate. http://www.bioassayontology.org/bao#BAO_0002098 depolarizer http://purl.obolibrary.org/obo/CHEBI_51086 chemical role The role of a molecular entity (e.g., barium chloride, acetylcholine) to change a cell's membrane potential, making it more positive. http://www.bioassayontology.org/bao#BAO_0002099 cell growth property http://purl.obolibrary.org/obo/PATO_0001396 cellular quality Cell line culturing describes the growth mode of a cell line, whether it grows attached to the culture dish (adherent) or floating (suspension) in the culture medium or partially attached (mixed adherent and suspension). http://www.bioassayontology.org/bao#BAO_0002102 media component http://purl.obolibrary.org/obo/CHEBI_24432 biological role The role played by a molecular entity that is added as an ingredient to a broth that is used to culture cells. http://www.bioassayontology.org/bao#BAO_0002105 transfection agent http://purl.obolibrary.org/obo/CHEBI_51086 chemical role The role of a molecular entity of mediating the introduction of a foreign nucleic acid into cells, e.g., Lipofectamine 2000, Fugene 6, etc. http://www.bioassayontology.org/bao#BAO_0002111 excitation filter http://www.bioassayontology.org/bao#BAO_0002110 fluorescence microscope filter An excitation filter is an optical-glass filter used in fluorescence microscopy for selection of the excitation wavelength of light from a light source. http://www.bioassayontology.org/bao#BAO_0002114 time endpoint http://www.bioassayontology.org/bao#BAO_0000179 endpoint An endpoint defined by a length in time at which a desired effect or observation occurs. http://www.bioassayontology.org/bao#BAO_0002115 T1/2 http://www.bioassayontology.org/bao#BAO_0002114 time endpoint Half-life of drug is the time taken for the concentration of the drug to decrease by half. http://www.bioassayontology.org/bao#BAO_0002116 dosage endpoint http://www.bioassayontology.org/bao#BAO_0000180 concentration endpoint An endpoint defined an effect seen in animals at a particular dosage, typically defined as a ratio of treatment to animal mass (e.g., mg/kg). http://www.bioassayontology.org/bao#BAO_0002119 Cmax http://www.bioassayontology.org/bao#BAO_0002118 graphical calculation endpoint The maximal concentration of a drug achieved following administration (maximum point of a concentration-time curve). http://www.bioassayontology.org/bao#BAO_0002121 slope http://www.bioassayontology.org/bao#BAO_0002118 graphical calculation endpoint Slope is described as the ratio of the change in y-axis divided by the change in x-axis between two points on a line or a curve. m= y2-y1 / x2-x1 http://www.bioassayontology.org/bao#BAO_0002122 amplification curve calculated endpoint http://www.bioassayontology.org/bao#BAO_0002118 graphical calculation endpoint Endpoint values derived from an exponential growth curve, such as in a PCR reaction. http://www.bioassayontology.org/bao#BAO_0002126 statistical endpoint http://www.bioassayontology.org/bao#BAO_0000181 response endpoint Endpoint values determined by a statistical measurement of the signal relative to the populations of signals observed. http://www.bioassayontology.org/bao#BAO_0002127 MAD score http://www.bioassayontology.org/bao#BAO_0002126 statistical endpoint The number of median absolute deviations outside the median of control or compound wells. http://www.bioassayontology.org/bao#BAO_0002128 physical property endpoint http://www.bioassayontology.org/bao#BAO_0000179 endpoint A measurement of an intrinsic property of a molecular entity. http://www.bioassayontology.org/bao#BAO_0002129 logD http://www.bioassayontology.org/bao#BAO_0002128 physical property endpoint Logarithm (log10) of the Distribution Coefficient, D, which is defined as the ratio of concentrations of a small molecule / drug distributed between octanol and water. LogD refers to the distribution of all forms of a compound between the two immiscible phases at equilibrium. It depends on pH of the aqueous phase, which is buffered to a specific value. A larger logD means the compound / drug is more hydrophobic (greasy) and a lower logD corresponds to better solubility in water. http://www.bioassayontology.org/bao#BAO_0002130 logP http://www.bioassayontology.org/bao#BAO_0002128 physical property endpoint Logarithm (log10) of the Partition Coefficient, P, which is defined as ratio of concentrations of a small molecule / drug distributed in octanol and water. LogP refers to the distribution of un-ionized (neutral species of) compound between the two immiscible phases at equilibrium; the pH is adjusted such that the major microspecies is the un-ionized form. A larger logP means the compound / drug is more hydrophobic (greasy) and a lower logP corresponds to better solubility in water. http://www.bioassayontology.org/bao#BAO_0002131 pKa http://www.bioassayontology.org/bao#BAO_0002128 physical property endpoint pKa is the negative log10 of the acid dissociation constant (Ka) of a molecule. Ka is the equilibrium constant for dissociation of the protonated base (acid) into the free base and a proton (hydromium ion). http://www.bioassayontology.org/bao#BAO_0002132 percent purity http://www.bioassayontology.org/bao#BAO_0002128 physical property endpoint Percent purity is the ratio of mass of pure compound to the actual mass of the available/vendor supplied compound, multiplied by 100. The majority of compounds and elemental substances are only available with a larger or smaller amount of impurities, which contribute to the mass of the impure compound. http://www.bioassayontology.org/bao#BAO_0002133 permeability A-B http://www.bioassayontology.org/bao#BAO_0002808 permeability This is measured to assess the transport of a drug across the cell monolayer in the apical to basolateral (A-B) direction. Typically, CaCo2 cells are used in the permeability measurements during the ADME phase, which model the intestinal epithelium.. http://www.bioassayontology.org/bao#BAO_0002134 permeability B-A http://www.bioassayontology.org/bao#BAO_0002808 permeability This is measured to assess the transport of a drug across the cell monolayer in the basolateral to apical (B-A) direction. Typically, CaCo2 cells are used in the permeability measurements during the ADME phase, which model the intestinal epithelium. http://www.bioassayontology.org/bao#BAO_0002135 solubility http://www.bioassayontology.org/bao#BAO_0002128 physical property endpoint The ability of a chemical substance to dissolve in a solid, liquid, or gaseous solvent to form a homogeneous solution. The solubility of a given substance is dependent on the solvent used, as well as on temperature and pressure. http://www.bioassayontology.org/bao#BAO_0002136 profile endpoint http://www.bioassayontology.org/bao#BAO_0000179 endpoint An endpoint defined by a set of measurements from a multiparametric assay. The set of measurements may be aggregated to an overall profile score, weighting each measurment in the profile relative to a desired outcome. http://www.bioassayontology.org/bao#BAO_0002141 activity threshold signal direction http://www.bioassayontology.org/bao#BAO_0002140 activity threshold specification The direction of the readout signal, relative to negative controls, which is considered to be of interest for determining active perturbagents (hits). http://www.bioassayontology.org/bao#BAO_0002143 robust z-prime factor http://www.bioassayontology.org/bao#BAO_0000028 assay quality assessment method A parameter defining the separation of the noise bands of the negative and positive controls in an experiment using robust statistics. The robust z' is defined as 1-(3*(MAD(pos)-MAD(neg))/abs(median(pos)-median(neg)) where MAD(pos) is the median absolute deviation of the positive control population and MAD(neg) is the median absolute deviation of the negative control population. Typically defined on a per-plate basis but may be defined for an overall assay. http://www.bioassayontology.org/bao#BAO_0002144 IC90 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint The effective concentration of an inhibitor, which produces 90% of the maximum possible response for that inhibitor. http://www.bioassayontology.org/bao#BAO_0002145 LC50 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint It is 50% lethal concentration (the concentration that kills 50% of treated cells). http://www.bioassayontology.org/bao#BAO_0002147 percent bound http://www.bioassayontology.org/bao#BAO_0000082 percent response It is a measure of the amount of radioligand that binds to its receptor in a competitive binding assay. It is the ratio of the bound to the total bound, where bound refers to the reading obtained from a binding reaction involving radioligand, receptor and a cold competitor ligand, while total bound is the reading obtained in the absence of any added competitor. http://www.bioassayontology.org/bao#BAO_0002148 percent recovery http://www.bioassayontology.org/bao#BAO_0000082 percent response In a purification assay, percent recovery is the ratio of mass of the entity obtained after the affinity purification to the mass of the unpurified entity originally added in the assay, multiplied by 100. http://www.bioassayontology.org/bao#BAO_0002152 signal decrease corresponding to activation http://www.bioassayontology.org/bao#BAO_0080025 signal decrease Increase in perturbation (reported by the endpoint mode of action, activation) is correlated to decrease in signal. http://www.bioassayontology.org/bao#BAO_0002153 signal increase corresponding to inhibition http://www.bioassayontology.org/bao#BAO_0080026 signal increase Increase in perturbation (reported by the endpoint mode of action, inhibition) is correlated to increase in signal. http://www.bioassayontology.org/bao#BAO_0002158 posttranscriptionally modified http://www.bioassayontology.org/bao#BAO_0000013 primary structure A quality of a DNA or RNA residue that has a group (e.g., methyl) attached to it after transcription. http://www.bioassayontology.org/bao#BAO_0002171 ln http://www.bioassayontology.org/bao#BAO_0002170 endpoint modifier Natural log (log base e) http://www.bioassayontology.org/bao#BAO_0002172 log http://www.bioassayontology.org/bao#BAO_0002170 endpoint modifier Log base 10 http://www.bioassayontology.org/bao#BAO_0002175 p http://www.bioassayontology.org/bao#BAO_0002170 endpoint modifier -(log10(endpoint)) http://www.bioassayontology.org/bao#BAO_0002185 measure group specification http://www.bioassayontology.org/bao#BAO_0003112 assay bioassay component An abstract concept to group one or more assay readout and allow description of an assay that measures one or more effect of a perturbagen on the biological entity. This does not define the physical readout method itself, which is captured in assay design, but rather classifies the data being generated by those readouts. http://www.bioassayontology.org/bao#BAO_0002202 assay design method http://www.bioassayontology.org/bao#BAO_0003028 assay method The assay design method describes how a biological or physical process screened / investigated in the model system is translated into a detectable signal. This relates to the technology / technologies used to make the assay system work, i.e. enable that the screened process can be detected. It typically involves some manipulation of the (biological) model system to detect the process of interest. http://www.bioassayontology.org/bao#BAO_0002203 computational analysis of gene expression http://www.bioassayontology.org/bao#BAO_0002166 computational expression analysis Computational methods used for analysis of microarrays, expressed cDNA sequence tag (EST) sequencing, serial analysis of gene expression (SAGE) tag sequencing, massively parallel signature sequencing (MPSS), or various applications of multiplexed in-situ hybridization. http://www.bioassayontology.org/bao#BAO_0002204 computational analysis of protein expression http://www.bioassayontology.org/bao#BAO_0002166 computational expression analysis Computational methods involved in analysis of protein microarrays and high throughput (HT) mass spectrometry (MS). http://www.bioassayontology.org/bao#BAO_0002206 computational phylogenetic analysis http://www.bioassayontology.org/bao#BAO_0002095 bioinformatics method Computational methods involved in construction and interpretation of phylogenetic trees, which are used to classify the evolutionary relationships between homologous genes represented in the genomes of divergent species. http://www.bioassayontology.org/bao#BAO_0002207 Mesquite phylogenetic analysis http://www.bioassayontology.org/bao#BAO_0002206 computational phylogenetic analysis Software for evolutionary biology, designed to help biologists analyze comparative data about organisms. Its emphasis is on phylogenetic analysis, but some of its modules concern population genetics, while others do non-phylogenetic multivariate analysis. http://www.bioassayontology.org/bao#BAO_0002209 Treefinder phylogenetic analysis http://www.bioassayontology.org/bao#BAO_0002206 computational phylogenetic analysis is a free computer program for the likelihood-based reconstruction of phylogenetic trees from molecular sequences. http://www.bioassayontology.org/bao#BAO_0002211 phylogeny inference package http://www.bioassayontology.org/bao#BAO_0002206 computational phylogenetic analysis A free Computational phylogenetics package of programs for inferring evolutionary trees (phylogenies). http://www.bioassayontology.org/bao#BAO_0002221 homology modeling http://www.bioassayontology.org/bao#BAO_0002216 3D structure prediction Also known as comparative modeling of protein, refers to constructing an atomic-resolution model of the "target" protein from its amino acid sequence and an experimental three-dimensional structure of a related homologous protein (the "template"). http://www.bioassayontology.org/bao#BAO_0002224 protein threading http://www.bioassayontology.org/bao#BAO_0002216 3D structure prediction A method of computational protein structure prediction used for protein sequences which have the same fold as proteins of known structures but do not have homologous proteins with known structure. http://www.bioassayontology.org/bao#BAO_0002225 RAPTOR protein threading http://www.bioassayontology.org/bao#BAO_0002224 protein threading protein threading software used for protein structure prediction, given a primary sequence. http://www.bioassayontology.org/bao#BAO_0002228 structure alignment http://www.bioassayontology.org/bao#BAO_0002216 3D structure prediction Structural alignment software attempts to establish equivalences between two or more polymer structures based on their shape and three-dimensional conformation. http://www.bioassayontology.org/bao#BAO_0002229 distance matrix alignment http://www.bioassayontology.org/bao#BAO_0002228 structure alignment DALI breaks the input structures into hexapeptide fragments and calculates a distance matrix by evaluating the contact patterns between successive fragments. http://www.bioassayontology.org/bao#BAO_0002231 sequence alignment http://www.bioassayontology.org/bao#BAO_0002095 bioinformatics method Computational methods used to arrange the sequences of DNA, RNA, or protein to identify regions of similarity that may be a consequence of functional, structural, or evolutionary relationships between the sequences. http://www.bioassayontology.org/bao#BAO_0002236 local sequence alignment http://www.bioassayontology.org/bao#BAO_0002232 sequence alignment by method Local alignments are more useful for dissimilar sequences that are suspected to contain regions of similarity or similar sequence motifs within their larger sequence context. http://www.bioassayontology.org/bao#BAO_0002237 FASTA local sequence alignment http://www.bioassayontology.org/bao#BAO_0002236 local sequence alignment Local search with fast k-tuple heuristic, slower but more sensitive than BLAST. http://www.bioassayontology.org/bao#BAO_0002238 basic local alignment search tool http://www.bioassayontology.org/bao#BAO_0002236 local sequence alignment Local search with fast k-tuple heuristic. http://www.bioassayontology.org/bao#BAO_0002240 Clustal sequence alignment http://www.bioassayontology.org/bao#BAO_0002245 multiple sequence alignment Multiple sequence alignment computer program. http://www.bioassayontology.org/bao#BAO_0002243 MAVID sequence alignment http://www.bioassayontology.org/bao#BAO_0002239 progressive system alignment is a multiple sequence alignment program suitable for the alignment of large numbers of DNA sequences. http://www.bioassayontology.org/bao#BAO_0002246 pairwise sequence alignment http://www.bioassayontology.org/bao#BAO_0002244 sequence alignment by type Pairwise sequence alignment methods are used to find the best-matching piecewise (local) or global alignments of two query sequences. http://www.bioassayontology.org/bao#BAO_0002248 cheminformatics method http://www.bioassayontology.org/bao#BAO_0002094 computational method Methods using of computer and informational techniques for problems in the field of chemistry http://www.bioassayontology.org/bao#BAO_0002249 conformational search http://www.bioassayontology.org/bao#BAO_0002248 cheminformatics method Consists of the exploration of energetically favorable spatial arrangements (shapes) of a molecule (conformations). http://www.bioassayontology.org/bao#BAO_0002256 Lipinski rule of 5 filtering http://www.bioassayontology.org/bao#BAO_0002255 database filtering Set of criteria for predicting the oral bioavailability of a compound on the basis of simple molecular features (molecular weight, CLogP, numbers of hydrogen- bond donors and acceptors). http://www.bioassayontology.org/bao#BAO_0002257 library design http://www.bioassayontology.org/bao#BAO_0002248 cheminformatics method Library design enables access to the large number of drug- like molecules that could theoretically be made and can serve several purposes: for example, to generate a maximally diverse virtual library for lead generation, a biased library aimed at a specific target or target family, or a lead optimization library. http://www.bioassayontology.org/bao#BAO_0002283 computer simulation method by force field http://www.bioassayontology.org/bao#BAO_0002282 computer simulation method A set of functions and parametrization used in molecular mechanics calculations. http://www.bioassayontology.org/bao#BAO_0002295 simulated annealing http://www.bioassayontology.org/bao#BAO_0002293 global minimum search a simulations procedure, in which the system is allowed to equilibrate at high temperatures, and then cooled down slowly to remove kinetic energy and to permit trajectories to settle into local minimum energy conformations. http://www.bioassayontology.org/bao#BAO_0002301 molecular dynamics simulation http://www.bioassayontology.org/bao#BAO_0002282 computer simulation method A simulation procedure consisting of the computation of the motion of atoms in a molecule or of individual atoms or molecules in solids, liquids and gases, according to Newton's laws of motion. The forces acting on the atoms, required to simulate their motions, are generally calculated using molecular mechanics force fields. http://www.bioassayontology.org/bao#BAO_0002312 three dimensional QSAR http://www.bioassayontology.org/bao#BAO_0002305 quantitative structure activity relationship analysis Involves the analysis of the quantitative relationship between the biological activity of a set of compounds and their three- dimensional properties using statistical correlation methods. http://www.bioassayontology.org/bao#BAO_0002313 comparative molecular field analysis http://www.bioassayontology.org/bao#BAO_0002312 three dimensional QSAR A 3D-QSAR method that uses statistical correlation techniques for the analysis of the quantitative relationship between the biological activity of a set of compounds with a specified alignment, and their three-dimensional electronic and steric properties. http://www.bioassayontology.org/bao#BAO_0002318 ab initio quantum chemistry computational method http://www.bioassayontology.org/bao#BAO_0002317 quantum chemistry computational method Methods of quantum mechanical calculations independent of any experiment other than the determination of fundamental constants. The methods are based on the use of the full Schr http://www.bioassayontology.org/bao#BAO_0002326 semi-empirical quantum chemistry computational method http://www.bioassayontology.org/bao#BAO_0002317 quantum chemistry computational method Use parameters derived from experimental data to simplify computations. http://www.bioassayontology.org/bao#BAO_0002364 virtual screening http://www.bioassayontology.org/bao#BAO_0002094 computational method Selection of compounds by evaluating their desirability in a computational model. http://www.bioassayontology.org/bao#BAO_0002366 ligand based pharmacophore model http://www.bioassayontology.org/bao#BAO_0002365 ligand based virtual screening The ligand-based ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response. http://www.bioassayontology.org/bao#BAO_0002373 molecular docking http://www.bioassayontology.org/bao#BAO_0002372 structure based virtual screening Method which predicts the preferred orientation of one molecule to a second when bound to each other to form a stable complex. http://www.bioassayontology.org/bao#BAO_0002401 enzyme-multiplied immunoassay technique http://www.bioassayontology.org/bao#BAO_0000466 ex situ immunoassay Enzyme multiplied immunoassay technique, or EMIT, is a common method for screening urine and blood for drugs, both legal or illicit. A mix and read protocol has been developed that is exceptionally simple and rapid. The most widely used applications for EMIT are for therapeutic drug monitoring (serum) and as a primary screen for abused drugs and their metabolites (urine). http://www.bioassayontology.org/bao#BAO_0002405 receptor based pharmacophore search http://www.bioassayontology.org/bao#BAO_0002372 structure based virtual screening The receptor-based ensemble of steric and electronic features that is necessary to ensure the optimal supramolecular interactions with a specific biological target structure and to trigger (or to block) its biological response. http://www.bioassayontology.org/bao#BAO_0002411 two site enzyme immunoassay http://www.bioassayontology.org/bao#BAO_0000466 ex situ immunoassay In a conventional 2-site enzyme immunoassay, the antigen under assay which must have two or more epitopes, is insolubilised by reaction with an unlabelled antibody conjugated to a solid phase and reacted with an enzyme-labelled antibody directed to a different (preferably roomly-spaced) epitope of the analyte. The quantity of labelled antibody which becomes immobilised due to the complexing reaction is directly proportional to the amount of analyte present in the sample. http://www.bioassayontology.org/bao#BAO_0002415 dot immunobinding assay http://www.bioassayontology.org/bao#BAO_0000466 ex situ immunoassay Dot immunobinding assay (Dot Iba) is a simple and highly reproducible immunodiagnostic method. Antibody or antigen is dotted directly onto nitrocellulose membrane (NCM) discs. The diagnostic material to be checked can be incubated on this disc. Presence of antigen antibody complex in NCM discs can be directly demonstrated with enzyme-conjugated antiglobulins and substrate. Development of a purple-pink colored, insoluble substrate product in the NCM will be considered a positive result in the assay. This assay allows the processing of multiple specimens at a time. http://www.bioassayontology.org/bao#BAO_0002416 checkerboard titration http://www.bioassayontology.org/bao#BAO_0002413 titration method A checkerboard titration is a single experiment in which the concentration of the two components is varied in a way that will result in a pattern. This method is often used to optimize reagent concentrations and to measure susceptibility to microbes to various agents. http://www.bioassayontology.org/bao#BAO_0002421 sandwich ELISA http://www.bioassayontology.org/bao#BAO_0000134 ELISA The sandwich ELISA measures the amount of antigen between two layers of antibodies. The antigens to be measured must contain at least two antigenic sites, capable of binding to antibody, since at least two antibodies act in the sandwich. So sandwich assays are restricted to the quantitation of multivalent antigens such as proteins or polysaccharides. Sandwich ELISAs for quantitation of antigens are especially valuable when the concentration of antigens is low and/or they are contained in high concentrations of contaminating protein. http://www.bioassayontology.org/bao#BAO_0002423 in-cell western assay http://www.bioassayontology.org/bao#BAO_0002422 immunoblot The In-Cell Western Assay is an immunocytochemical assay that uses NIR fluorescence to detect and quantify proteins in fixed cells. Detecting proteins in their cellular context increases quantification precision. Proteins in fixed, cultured cells are detected directly in microplates, which yields higher throughput compared to Western blotting and eliminates typical Western blotting steps such as cell lysate preparation, electrophoresis, and membrane transfer. Using the In-Cell Western Assay kits, the cost per well for secondary screening is reduced to a fraction of the cost of typical western blots. http://www.bioassayontology.org/bao#BAO_0002425 immunolabeling method http://www.bioassayontology.org/bao#BAO_0002452 labeling method Immunolabeling is a means of localizing particular antigens within tissue. Immunolabeling is a methodological process where: 1) antibodies are used to identify antigens within an organism and 2) a tag (e.g. through fluorescence, gold beads, epitope tag, etc.) is added to a secondary antibody which binds to the primary antibody. http://www.bioassayontology.org/bao#BAO_0002426 immunofluorescent labeling http://www.bioassayontology.org/bao#BAO_0002425 immunolabeling method Immunofluorescence is the labeling of antibodies or antigens with fluorescent dyes. http://www.bioassayontology.org/bao#BAO_0002427 immunogold labeling http://www.bioassayontology.org/bao#BAO_0002425 immunolabeling method Immunolabeling method in which gold particles are conjugated to a primary or secondary antibody and used for identification of an antigen. http://www.bioassayontology.org/bao#BAO_0002429 assay supporting method http://www.bioassayontology.org/bao#BAO_0003028 assay method Assay supporting methods describe the methods to prepare, generate or post-process the assay system or assay screening process. Such methods include the sample preparation, labeling, data processing, etc., which are required to performing the assay, but do not constitute the actual assay (design method). http://www.bioassayontology.org/bao#BAO_0002430 serial analysis of gene expression http://www.bioassayontology.org/bao#BAO_0002447 nucleic acid sequencing method Serial analysis of gene expression (SAGE) is a technique used by molecular biologists to produce a snapshot of the messenger RNA population in a sample of interest in the form of small tags that correspond to fragments of those transcripts. http://www.bioassayontology.org/bao#BAO_0002450 nucleic acid amplification method http://www.bioassayontology.org/bao#BAO_0002445 genotyping method A method that uses purified enzymes to isolate and then replicate specific nucleic acids to levels where they can be detected. Examples are PCR, TMA, NASBA, etc. http://www.bioassayontology.org/bao#BAO_0002451 chromosome mapping http://www.bioassayontology.org/bao#BAO_0002445 genotyping method Mapping is the construction of a series of chromosome descriptions that depict the position and spacing of unique, identifiable biochemical landmarks, including some genes, that occur on the DNA of chromosomes. http://www.bioassayontology.org/bao#BAO_0002456 MTS reduction assay http://www.bioassayontology.org/bao#BAO_0002455 colorimetric cell staining method The the MTS assay is a laboratory test and a standard colorimetric assay (an assay which measures changes in color) for measuring the activity of enzymes that reduce MTS + PMS to formazan, giving a purple color. MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium), in the presence of phenazine methosulfate (PMS), produces a water-soluble formazan product that has an absorbance maximum at 490-500 nm in phosphate-buffered saline. It is advantageous over MTT in that (1) the reagents MTS + PMS are reduced more efficiently than MTT, and (2) the product is water soluble, decreasing toxicity to cells seen with an insoluble product. http://www.bioassayontology.org/bao#BAO_0002458 XTT reduction assay http://www.bioassayontology.org/bao#BAO_0002455 colorimetric cell staining method The XTT Cell Proliferation Assay is a colorimetric assay system which measures the reduction of a tetrazolium component (XTT) into soluble formazan product by the mitochondria of viable cells. The samples are read using an ELISA plate reader at a wavelength of 450nm. The amount of color produced is directly proportional to the number of viable cells. http://www.bioassayontology.org/bao#BAO_0002459 resazurin reduction assay http://www.bioassayontology.org/bao#BAO_0002455 colorimetric cell staining method For spectrophotometric measurement of metabolic activity of living cells. Absorbance of converted dye is measured at a wavelength of 600 nm. Bioreduction of the dye reduces the amount of its oxidized form (blue) and concomitantly increases the fluorescent intermediate (red). http://www.bioassayontology.org/bao#BAO_0002460 sulforhodamine B staining http://www.bioassayontology.org/bao#BAO_0002462 colorimetric protein staining method The sulforhodamine B (SRB) assay is used for cell density determination, based on the measurement of cellular protein content. http://www.bioassayontology.org/bao#BAO_0002463 Bradford protein assay http://www.bioassayontology.org/bao#BAO_0002462 colorimetric protein staining method The Bradford assay, a colorimetric protein assay, is based on an absorbance shift in the dye Coomassie when the previously red form coomassie reagent changes and stabilizes into coomassie blue by the binding of protein. http://www.bioassayontology.org/bao#BAO_0002464 Coomassie dye protein staining http://www.bioassayontology.org/bao#BAO_0002462 colorimetric protein staining method Coomassie dyes (also known as Coomassie Brilliant Dyes) are a family of dyes commonly used to stain proteins in sodium dodecyl sulfate and blue native polyacrylamide gel electrophoresis (SDS-PAGE and BN-PAGE, respectively) gels. http://www.bioassayontology.org/bao#BAO_0002465 Lowry assay http://www.bioassayontology.org/bao#BAO_0002462 colorimetric protein staining method The Lowry protein assay is a biochemical assay for determining the total level of protein in a solution. The total protein concentration is exhibited by a color change of the sample solution in proportion to protein concentration, which can then be measured using colorimetric techniques. http://www.bioassayontology.org/bao#BAO_0002466 Ponceau S protein staining http://www.bioassayontology.org/bao#BAO_0002462 colorimetric protein staining method Ponceau S, Acid Red 112, or C.I. 27195 is a sodium salt of a diazo dye that may be used to prepare a stain for rapid reversible detection of protein bands on nitrocellulose or PVDF membranes (Western blotting), as well as on cellulose acetate membranes. A Ponceau S stain is easily reversed with water washes, facilitating subsequent immunological detection. http://www.bioassayontology.org/bao#BAO_0002467 bicinchoninic acid assay http://www.bioassayontology.org/bao#BAO_0002462 colorimetric protein staining method The bicinchoninic acid assay (also known as the BCA assay or Smith assay) is a biochemical assay for determining the total level of protein in a solution, similar to Lowry protein assay, Bradford protein assay or biuret reagent. The total protein concentration is exhibited by a color change of the sample solution from green to purple in proportion to protein concentration, which can then be measured using colorimetric techniques. http://www.bioassayontology.org/bao#BAO_0002468 crystal violet staining http://www.bioassayontology.org/bao#BAO_0002453 colorimetric labeling method Crystal violet is a dye derived from gentian violet that is used as a general biological stain and an acid-base indicator. http://www.bioassayontology.org/bao#BAO_0002474 ethidium bromide DNA staining http://www.bioassayontology.org/bao#BAO_0002472 fluorescent DNA intercalation method Ethidium bromide is an intercalating agent used as a fluorescent tag (nucleic acid stain) in molecular biology laboratories for various techniques. When exposed to ultraviolet light, it will fluoresce with an orange colour, intensifying almost 20-fold after binding to DNA. http://www.bioassayontology.org/bao#BAO_0002476 propidium iodide DNA staining http://www.bioassayontology.org/bao#BAO_0002472 fluorescent DNA intercalation method Propidium iodide (or PI) is an intercalating agent and a fluorescent molecule with a molecular mass of 668.4 Da that can be used to stain DNA. When excited by 488 nm of laser light, it can be detected with 562-588 nm band pass filter. http://www.bioassayontology.org/bao#BAO_0002479 photoaffinity labeling http://www.bioassayontology.org/bao#BAO_0002452 labeling method A technique of attaching a label to the active site of a large molecule and especially a protein by using a molecule which binds loosely and reversibly to the large molecule's active site and which has an inactive part that can be converted by photolysis to a highly reactive form causing the complex of the large substrate molecule and the loosely attached label to bind more permanently. http://www.bioassayontology.org/bao#BAO_0002481 dye exclusion method http://www.bioassayontology.org/bao#BAO_0002480 vital dye staining Dye staining method in which the dye is excluded from particular cells, usually due to the presence of an intact plasma membrane. http://www.bioassayontology.org/bao#BAO_0002482 propidium iodide exclusion http://www.bioassayontology.org/bao#BAO_0002481 dye exclusion method Dye uptake assays using neutral red, trypan blue and fluorescent compounds such as propidium iodide are traditional methods to assess cell viability and membrane damage. Trypan blue and fluorescent compounds such as propidium iodide are excluded by healthy, functional cell membranes but are able to traverse damaged cell membranes thereby preferentially staining dead cells. http://www.bioassayontology.org/bao#BAO_0002489 hybrid screening http://www.bioassayontology.org/bao#BAO_0002488 genetic complementation Refers to variations on the two-hybrid technique, which measures activation of a reporter gene caused by binding between fusion proteins or other molecular entities. http://www.bioassayontology.org/bao#BAO_0002491 three-hybrid assay http://www.bioassayontology.org/bao#BAO_0002489 hybrid screening RNA-protein interactions have been investigated through a three-hybrid variation of the two-hybrid technique. In this case, a hybrid RNA molecule serves to adjoin together the two protein fusion domains which are not intended to interact with each other but rather the intermediary RNA molecule (through their RNA-binding domains). http://www.bioassayontology.org/bao#BAO_0002492 two-hybrid assay http://www.bioassayontology.org/bao#BAO_0002489 hybrid screening A molecular biology technique used to discover protein-protein interactions and protein-DNA interactions by testing for physical interactions (such as binding) between two proteins or a single protein and a DNA molecule, respectively. The premise behind the test is the activation of downstream reporter gene(s) by the binding of a transcription factor onto an upstream activating sequence (UAS). For two-hybrid screening, the transcription factor is split into two separate fragments, called the binding domain (BD) and activating domain (AD). The BD is the domain responsible for binding to the UAS and the AD is the domain responsible for the activation of transcription. http://www.bioassayontology.org/bao#BAO_0002493 mammalian two-hybrid assay http://www.bioassayontology.org/bao#BAO_0002492 two-hybrid assay Two-hybrid assay performed in mammalian cells. http://www.bioassayontology.org/bao#BAO_0002503 immunocapture http://www.bioassayontology.org/bao#BAO_0002502 antibody-based separation method using capture antibodies which are able to isolate large enzyme complexes in the their fully intact, fully active states from small samples of tissue or cells. http://www.bioassayontology.org/bao#BAO_0002504 immunochromatography http://www.bioassayontology.org/bao#BAO_0002502 antibody-based separation method Test based on a strip of paper coated with an immobilized antibody specific for an antigen that is characteristic of a disease. Samples conjugated to a second antibody (which allows chromogenic detection) can be applied to the paper strip and results visualized in less than 10 minutes. By using multiple antigens at different positions on the strip, multiple diseases can be screened for in one sample. http://www.bioassayontology.org/bao#BAO_0002505 immunodepletion http://www.bioassayontology.org/bao#BAO_0002502 antibody-based separation method The removal of certain proteins by the use of antibodies. http://www.bioassayontology.org/bao#BAO_0002508 immunoprecipitation http://www.bioassayontology.org/bao#BAO_0002502 antibody-based separation method It is the technique of precipitating a protein antigen out of solution using an antibody that specifically binds to that particular protein. This process can be used to isolate and concentrate a particular protein from a sample containing many thousands of different proteins. Immunoprecipitation requires that the antibody be coupled to a solid substrate at some point in the procedure. http://www.bioassayontology.org/bao#BAO_0002528 phosphorimaging http://www.bioassayontology.org/bao#BAO_0000657 radiometry method The use of photostimulated luminescence to make a form of X-ray image. http://www.bioassayontology.org/bao#BAO_0002539 protein tag http://purl.obolibrary.org/obo/CHEBI_24432 biological role The role of the peptide that is appended at the N- or C-terminal of a protein (e.g., GST, His, HA, Myc, etc) which allows for easy identification and/or separation of that protein. http://www.bioassayontology.org/bao#BAO_0002554 protein complex http://www.bioassayontology.org/bao#BAO_0003111 biological macromolecule Two or more proteins interact to form a stable complex. Each of the members of this complex has a distinct role in mediating the overall function of the complex, which can be as a chaperone (DnaK, DnaJ and grpE), an enzyme (mitochondrial respiratory complexes), a signaling complex (G-proteins), etc. It can be viewed as a quaternary structure of the proteins. http://www.bioassayontology.org/bao#BAO_0002555 protein subunit http://www.bioassayontology.org/bao#BAO_0003111 biological macromolecule The individual protein molecule of a protein complex. In the complex, it associates with other protein subunits which are either the same or different, e.g., hemoglobin, microtubule, etc. http://www.bioassayontology.org/bao#BAO_0002590 organization role http://www.bioassayontology.org/bao#BAO_0002929 role The role of an organization or individual in the various stages of implementation of an assay, such as manufacturing an assay kit or depositing an assay in a repository. http://www.bioassayontology.org/bao#BAO_0002596 culture serum http://www.bioassayontology.org/bao#BAO_0003116 material entity The serum used in cell culture medium. Cultured cells require serum or growth factors for growth by cell division. In the laboratory, each cell type is grown in a medium supplemented with a variable concentration of serum (up to 20%) which is optimized for its growth. Specialized sera include dextran charcoal treated serum, which lacks certain hormones, growth factors, etc, dialyzed serum, which lacks low molecular weight molecules (below 10,000 MW), such as glucose, amino acids, low molecular weight hormones, cytokines, etc. Most commonly, fetal bovine serum is used in cell culture, but other sera such as horse serum are also used. http://www.bioassayontology.org/bao#BAO_0002597 assay serum http://www.bioassayontology.org/bao#BAO_0003116 material entity The serum used in assay medium while performing a cell-based assay and is optimized for each assay type. In certain assays, the cells could be maintained at either a lower concentration of the serum or in a specialized serum, including dextran charcoal treated serum, dialyzed serum, etc. This is done to avoid interference with the assay measurements. http://www.bioassayontology.org/bao#BAO_0002609 antibody isotype http://purl.obolibrary.org/obo/PATO_0002182 molecular quality The different varieties or classes of antibodies, which differ in their properties and biological functions. http://www.bioassayontology.org/bao#BAO_0002624 commercial vendor http://www.bioassayontology.org/bao#BAO_0002590 organization role The role of a company as a creator of an assay kit, compound library, or detection instrument. http://www.bioassayontology.org/bao#BAO_0002625 academic chemist http://www.bioassayontology.org/bao#BAO_0002900 researcher role The role of an individual, who works at an academic institution as a creator of a chemical compound. http://www.bioassayontology.org/bao#BAO_0002626 biologics and screening manufacturer http://www.bioassayontology.org/bao#BAO_0002624 commercial vendor The role of a company as a creator of reagents and assay kits. http://www.bioassayontology.org/bao#BAO_0002627 compound library manufacturer http://www.bioassayontology.org/bao#BAO_0002624 commercial vendor The role of a company as a creator of a compound library. http://www.bioassayontology.org/bao#BAO_0002636 bandwidth http://purl.obolibrary.org/obo/PATO_0001018 physical quality Bandwidth is the range of wavelength of light that it allows to pass through the filter, which is either excitation or emission type. http://www.bioassayontology.org/bao#BAO_0002642 antibody role http://purl.obolibrary.org/obo/CHEBI_24432 biological role This categorizes the distinct roles played by antibodies in recognizing either the antigen or an antibody itself. http://www.bioassayontology.org/bao#BAO_0002643 primary antibody http://www.bioassayontology.org/bao#BAO_0002642 antibody role The role of an antibody to detect and bind a specific antigen in a sample (cell, tissue, protein blot). http://www.bioassayontology.org/bao#BAO_0002644 secondary antibody http://www.bioassayontology.org/bao#BAO_0002642 antibody role The role of an antibody to detect and bind a primary antibody in a sample (cell, tissue, protein blot). http://www.bioassayontology.org/bao#BAO_0002656 reporter gene http://purl.obolibrary.org/obo/CHEBI_24432 biological role A gene that performs the role of encoding a reporter protein, which can easily be detected in an assay, e.g., luciferase gene that encodes the luciferase protein. DNA constructs that contain reporter genes are excellent tools to understand regulation of gene expression. http://www.bioassayontology.org/bao#BAO_0002718 BSR http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 A clone of BHK (Baby hamster kidney) cells. http://www.bioassayontology.org/bao#BAO_0002726 assay component http://purl.obolibrary.org/obo/CHEBI_24432 biological role The role played by a molecular entity that is added as an ingredient to an assay. http://www.bioassayontology.org/bao#BAO_0002743 Anti-MPM-2 http://www.bioassayontology.org/bao#BAO_0000503 monoclonal Recognizes a phosphorylated epitope (S/T)P found in phosphoproteins such as MAP2, HSP70, cdc25, and DNA topoisomerase IIa, most of which are phosphorylated at the onset of mitosis. The number of phosphoproteins recognized by MPM-2 varies from species to species and with the cell type. http://www.bioassayontology.org/bao#BAO_0002750 normalization based on control http://www.bioassayontology.org/bao#BAO_0000075 endpoint normalization method Raw sample measurements are normalized relative to positive and negative control samples with known activity and inactivity. Endpoints are usually expressed as percentage, which include percent activity, percent inhibition, etc. http://www.bioassayontology.org/bao#BAO_0002751 normalization without control http://www.bioassayontology.org/bao#BAO_0000075 endpoint normalization method Where control samples are not available, data can be normalized statistically assuming that the majority of the samples are negative, i.e. not active. An example is z-score. http://www.bioassayontology.org/bao#BAO_0002752 measured concentration http://www.bioassayontology.org/bao#BAO_0000180 concentration endpoint Measured / detected concentration of the perturbagen / compound in the assay or a subsystem (locally) in the assay. For example measured absolute concentration in the brain. This is in contrast to screening concentration, which is the (final assumed) concentration of a compound added to the assay. http://www.bioassayontology.org/bao#BAO_0002754 assay data processing method http://www.bioassayontology.org/bao#BAO_0002429 assay supporting method Methods to process the measurement into the result type / endpoint reported as the final outcome of the assay; or other characteristics of the assay, which as data characterizing quality of an assay. Includes endpoint normalization and assay quality assessment. http://www.bioassayontology.org/bao#BAO_0002768 T1/2(in vitro) http://www.bioassayontology.org/bao#BAO_0002115 T1/2 The time taken for the concentration of the drug in an in-vitro system (e.g., liver microsomes) to decrease by half. http://www.bioassayontology.org/bao#BAO_0002773 CL(renal) http://www.bioassayontology.org/bao#BAO_0002759 CL Clearance of the drug due to renal excretion. http://www.bioassayontology.org/bao#BAO_0002774 CL(hepatic) http://www.bioassayontology.org/bao#BAO_0002759 CL Clearance of the drug due to hepatic enzyme activity and biliary excretion. http://www.bioassayontology.org/bao#BAO_0002775 aqueous solubility http://www.bioassayontology.org/bao#BAO_0002135 solubility The ability of a chemical substance to dissolve in water. http://www.bioassayontology.org/bao#BAO_0002873 chemist http://www.bioassayontology.org/bao#BAO_0165001 researcher A person that performs scientific research and could have the capability of synthesizing new chemical entities. http://www.bioassayontology.org/bao#BAO_0002878 AC10 absolute http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint The compound concentration at which the fitted curve passes activity threshold 10. http://www.bioassayontology.org/bao#BAO_0002907 allosteric activation http://www.bioassayontology.org/bao#BAO_0000087 activation Small molecule that can bind to sites other than the receptor active site and affect activity of the receptor. http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0002935 automated cytometer An imageing cytometer is an instrument for image-based study or measurement of cells. (definition from OBI) http://www.bioassayontology.org/bao#BAO_0002970 counting parameter http://www.bioassayontology.org/bao#BAO_0002969 assay readout parameter counting parameter is an output of the device measuring the number of the subject. http://www.bioassayontology.org/bao#BAO_0002971 densitometric parameter http://www.bioassayontology.org/bao#BAO_0002969 assay readout parameter densitometric parameter is an output of the device that is the density value of the subject by measuring the amount of light or fluorescence detected on the image. http://www.bioassayontology.org/bao#BAO_0002972 intensity parameter http://www.bioassayontology.org/bao#BAO_0002969 assay readout parameter intensity parameter is an output of the device measuring the intensity value for the light signal of the subject. http://www.bioassayontology.org/bao#BAO_0002990 protein-protein interaction assay http://www.bioassayontology.org/bao#BAO_0002989 binding assay It is performed to quantify the interactions between two protein molecules, using methods such as protein fragment complementation assay, immunoassay, radioligand binding, etc. http://www.bioassayontology.org/bao#BAO_0002991 cell morphology assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay It reports the size and shape of cells and organelles (phenotype). These are detected by microscopy. http://www.bioassayontology.org/bao#BAO_0002992 cell motility assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay It is performed to measure the movement of cells and organelles (phenotype). These are detected by microscopy. http://www.bioassayontology.org/bao#BAO_0002996 membrane potential assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay This reports the membrane potential of a cell by using electrophysiological techniques or by staining with dyes whose binding is dependent on the membrane potential. http://www.bioassayontology.org/bao#BAO_0002997 ion channel assay http://www.bioassayontology.org/bao#BAO_0002996 membrane potential assay Ion channel assays are performed in electrically active cells: neurons, muscle, and endocrine cells. http://www.bioassayontology.org/bao#BAO_0002998 protein folding assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay This assay quantifies the protein folding/conformation using technologies, such as nuclear magnetic resonance, circular dichroism are used to determine the protein folding/conformation. http://www.bioassayontology.org/bao#BAO_0002999 redistribution assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay It is performed to measure the redistribution of organelles and molecules within the cell (proteins, second messengers, metal ions, dyes, etc. ). This is visualized by microscopy. http://www.bioassayontology.org/bao#BAO_0003000 rna splicing assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay This assay quantifies the amount of a mature transcript that is produced after splicing. Splicing is a modification of an mRNA intermediate after transcription, in which introns are removed and exons are joined. It can be detected by several methods, namely, the use of a reporter gene, RNA-Seq, specialiez microarrays, etc. http://www.bioassayontology.org/bao#BAO_0003001 sensitizer assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay This assay allows the identification of new drugs that sensitize or desensitize the sensitivity of a cell to its signaling molecule (e.g calcium, light). The perturbagen has the role 'sensitizer' in this assay. http://www.bioassayontology.org/bao#BAO_0003004 posttranslation modification assay http://www.bioassayontology.org/bao#BAO_0003002 signal transduction assay This assay quantifies the modification that a protein can undergo after it is synthesized by translation. E.g. phosphorylation, acetylation, etc. The modification status is detected by one of several methods such as using modification specific antibodies followed by western blotting, imaging; mass spectrometry, etc. http://www.bioassayontology.org/bao#BAO_0003007 second messenger assay http://www.bioassayontology.org/bao#BAO_0003002 signal transduction assay This assay quantifies the second messengers (calcium, cAMP, cGMP) produced in the cell as a result of a signaling event. http://www.bioassayontology.org/bao#BAO_0003010 protein-turnover assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay This assay quantifies the protein turnover, which is a natural phenomenon in healthy cells, but becomes aberrant in diseased cells. The protein that is needed to be degraded first undergoes ubiquitinated. Ubiquitinated proteins are degraded in the proteasome complex. The protein degradation is quantitated by using reporters, such as green fluorescent protein as proteasome substrates. http://www.bioassayontology.org/bao#BAO_0003019 regulatory region http://www.bioassayontology.org/bao#BAO_0003018 DNA region The DNA region that is involved in initiating and modulating transcription. http://www.bioassayontology.org/bao#BAO_0003020 transcribed region http://www.bioassayontology.org/bao#BAO_0003018 DNA region The region of a gene that codes for RNA. http://www.bioassayontology.org/bao#BAO_0003021 artificial regulatory region http://www.bioassayontology.org/bao#BAO_0003019 regulatory region A synthetic DNA element that is known to be regulated by a transcription factor/s, which is cloned upstream of a gene of interest. http://www.bioassayontology.org/bao#BAO_0003023 native promoter region http://www.bioassayontology.org/bao#BAO_0003019 regulatory region The regulatory DNA from a native gene, e.g., the regulatory region from the actin gene being cloned upstream of the actin gene in a DNA construct. http://www.bioassayontology.org/bao#BAO_0003026 nucleic acid array method http://www.bioassayontology.org/bao#BAO_0003034 nucleic acid identification and quantitation method Gene-specific DNA is immobilized by spotting on a solid support, such as a glass slide. The DNA is hybridized with labeled nucleic acids from a sample and the signals measured, which reflect the composition of the sample nucleic acids. This is performed to quantify gene expression under various situations,e.g. diseases, development, etc. http://www.bioassayontology.org/bao#BAO_0003027 rna-seq method http://www.bioassayontology.org/bao#BAO_0002447 nucleic acid sequencing method RNA-Seq is an approach for transcriptome profiling which uses deep-sequencing technologies. RNA-Seq, also called "Whole Transcriptome Shotgun Sequencing" ("WTSS") and dubbed "a revolutionary tool for transcriptomics", refers to the use of High-throughput sequencing technologies to sequence cDNA in order to get information about a sample's RNA content, a technique that is quickly becoming invaluable in the study of diseases like cancer. Thanks to the deep coverage and base level resolution provided by next-generation sequencing instruments, RNA-Seq provides researchers with efficient ways to measure transcriptome data experimentally, allowing them to get information such as how different alleles of a gene are expressed, detect post-transcriptional mutations or identifying gene fusions. http://www.bioassayontology.org/bao#BAO_0003028 assay method http://www.bioassayontology.org/bao#BAO_0002753 assay method component The methods required to perform typical screening assay. These include the assay design methods (to generate a detectable signal) and assay supporting methods. Assay methods include laboratory methods. Computational methods are not currently categorized as assay methods, although some may also be used to process the assay measurement results. http://www.bioassayontology.org/bao#BAO_0003038 pA2 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint The negative logarithm (log10) of the molar concentration of antagonist which requires the agonist concentration to be doubled in order to achieve the original response. http://www.bioassayontology.org/bao#BAO_0003048 permanent cell line http://purl.obolibrary.org/obo/CLO_0000001 细胞系细胞 A cell line that is immortalized. http://www.bioassayontology.org/bao#BAO_0003052 cellular component http://www.bioassayontology.org/bao#BAO_0003114 assay biology component The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together (from Gene Ontology). http://www.bioassayontology.org/bao#BAO_0003058 inducer http://purl.obolibrary.org/obo/CHEBI_51086 chemical role The role of a molecular entity to initiate a biological process. E.g., interferon-gamma has an inducer role in STAT-1 mediated transcriptional activation of cells. http://www.bioassayontology.org/bao#BAO_0003059 perturbagen http://purl.obolibrary.org/obo/CHEBI_51086 chemical role The role of a molecular entity (small molecule, siRNA/shRNA, etc.) in altering the activity of proteins that serve as targets in a bioassay. http://www.bioassayontology.org/bao#BAO_0003060 potentiator http://purl.obolibrary.org/obo/CHEBI_51086 chemical role The role of a molecular entity as a known activator of a target/pathway, added prior to screening the compounds for selective inhibitor indications (e.g., forskolin is a potentiator for Gi/o pathway of G-proteins). http://www.bioassayontology.org/bao#BAO_0003061 reporter protein http://purl.obolibrary.org/obo/CHEBI_24432 biological role The role of a protein to be easily detected in an assay by virtue of its innate properties (fluorescence) or catalyzing a reaction that result in easily measurable products, such as luminescence, colored product, etc. Examples include luciferase, GFP, beta-galactosidase, etc. http://www.bioassayontology.org/bao#BAO_0003062 sensitizer http://purl.obolibrary.org/obo/CHEBI_51086 chemical role The role of a compound to increase or decrease the ability of a cell to respond to its signaling molecule. http://www.bioassayontology.org/bao#BAO_0003063 substrate http://purl.obolibrary.org/obo/CHEBI_24432 biological role The role of a molecular entity to serve as the input for an enzymatic reaction that generates a product, e.g. ATP has the role of a substrate for ATPase, which hydrolyzes it to produce ADP and Pi. http://www.bioassayontology.org/bao#BAO_0003064 target http://purl.obolibrary.org/obo/CHEBI_24432 biological role The role of a molecular entity (protein or nucleic acid) that is the presumed subject of an assay and whose activity is being regulated by an entity with a perturbagen role in that assay. http://www.bioassayontology.org/bao#BAO_0003066 depolarization blocker http://www.bioassayontology.org/bao#BAO_0002085 channel blocker A chemical entity that has the role of depolarization, which is to make the cell's membrane potential more negative. http://www.bioassayontology.org/bao#BAO_0003068 selectable marker http://purl.obolibrary.org/obo/CHEBI_24432 biological role The role of a chemical entity to distinguish two populations of cells, e.g., ampicillin is added to culture medium to identify ampicillin resistant bacteria. http://www.bioassayontology.org/bao#BAO_0010018 gel http://www.bioassayontology.org/bao#BAO_0000512 assay footprint Gel electrophoresis is a method for separation and analysis of macromolecules (DNA, RNA and proteins) and their fragments, based on their size and charge. This general method encompasses different types of matrices (gels) with different properties. The most common types are polyacrylamide and agarose, both low-throughput methods. http://www.bioassayontology.org/bao#BAO_0010019 PAGE http://www.bioassayontology.org/bao#BAO_0010018 gel Polyacrylamide gel electrophoresis (PAGE), describes a technique to separate biological macromolecules, usually proteins or nucleic acids, according to their electrophoretic mobility. Mobility is a function of the length, conformation and charge of the molecule. Gels can be native or denaturing (urea for nucleic acids, SDS for proteins). A low-throughput method. http://www.bioassayontology.org/bao#BAO_0010020 agarose gel http://www.bioassayontology.org/bao#BAO_0010018 gel Agarose gel electrophoresis is a method to separate a mixed population of DNA or proteins in a matrix of agarose. The proteins may be separated by charge and/or size, and the DNA and RNA fragments by length, by applying an electric field to move the charged molecules through an agarose matrix. A low-throughput method. http://www.bioassayontology.org/bao#BAO_0010021 coverslip http://www.bioassayontology.org/bao#BAO_0000512 assay footprint Coverslips are typically thin square pieces of glass http://www.bioassayontology.org/bao#BAO_0010022 16-well electronic plate http://www.bioassayontology.org/bao#BAO_0000508 microplate 16 well electronic plate ('E Plate 16' (Roche Diagnostics)), used for electrophysiology http://www.bioassayontology.org/bao#BAO_0010023 chip http://www.bioassayontology.org/bao#BAO_0000512 assay footprint The word 'chip' is used to describe any flat surface (glass, plastic, other) that may be coated or treated to impart certain properties to help in either the immobilization and/or measurement of certain properties of varied macromolecules (protien, nucleic acid, small molecule). If an array of molecules is immobilized on a chip, the preferred term is 'array'. http://www.bioassayontology.org/bao#BAO_0010024 Sensor chip CM5 http://www.bioassayontology.org/bao#BAO_0010023 chip Sensor chip CM5 is a chip used in Biacore (GE Healthcare) systems based on surface plasmon resonance (SPR) to measure molecular interactions with at least one molecule immobilized on a sensor surface. CM5 sensor chips have a matrix of carboxymethylated dextran covalently attached to a gold surface. http://www.bioassayontology.org/bao#BAO_0010025 preclinical development stage http://www.bioassayontology.org/bao#BAO_0000029 assay screening campaign stage Assays performed in the pre-clinical development stage. These are assays on a lead candidate to develop it to an Investigative New Drug (IND). This stage typically includes both in vitro and in vivo assays, including thorough PK/PD profiling, toxicity, and in vivo dosing/ formulation optimization for efficacy. http://www.bioassayontology.org/bao#BAO_0010027 shotgun MS protein profiling assay http://www.bioassayontology.org/bao#BAO_0010026 protein profiling assay An assay that is used to identify in a data-dependent mode proteins by combining the HPLC and MS methods. It is also known as liquid chromatography-coupled tandem mass spectrometry (LC-MS) http://www.bioassayontology.org/bao#BAO_0010028 SWATH MS protein profiling assay http://www.bioassayontology.org/bao#BAO_0010026 protein profiling assay Sequential window acquisition of all theoretical mass spectra (SWATH) MS is a mass spectrometrical method thatcouples data-independent acquisition is coupled with peptide spectral library match http://www.bioassayontology.org/bao#BAO_0010029 P100 protein profiling assay http://www.bioassayontology.org/bao#BAO_0010026 protein profiling assay A targeted phosphoproteomic assay that uses a data-driven approach to identify and quantify a set of 96 phosphopeptide probes http://www.bioassayontology.org/bao#BAO_0010030 RPPA protein profiling assay http://www.bioassayontology.org/bao#BAO_0010026 protein profiling assay Reverse phase protein array (RPPA) is a an assay that measures multiple protein expression levels in a large number of biological samples simultaneously using high quality antibodies http://www.bioassayontology.org/bao#BAO_0010031 epigenetic assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay Epigenetic assays that can be used to identify epigenome modifications together with the epigenetic enzymes that regulate it. The epigenetic assays are split in two categories: targeted epigenetic assays and epigenetic profiling assays depending on whether they are used to identify a modifications on a global scale or only measure and identify a predetermined list of targets http://www.bioassayontology.org/bao#BAO_0010032 targeted epigenetic assay http://www.bioassayontology.org/bao#BAO_0010031 epigenetic assay Assays that measure a targeted and predetermined subset of the epigenetic modifications in a cell http://www.bioassayontology.org/bao#BAO_0010033 acetylated histone assay http://www.bioassayontology.org/bao#BAO_0010032 targeted epigenetic assay An assay that quantifies the levels of the acetylated histones in a cell. Acetylated histones are involved in the regulation of chromatin structure and thetranscription factor recruitment http://www.bioassayontology.org/bao#BAO_0010034 methylated histone assay http://www.bioassayontology.org/bao#BAO_0010032 targeted epigenetic assay An assay that quantifies the levels of the methylated histones in a cell http://www.bioassayontology.org/bao#BAO_0010035 ChIP-seq assay http://www.bioassayontology.org/bao#BAO_0010032 targeted epigenetic assay An assay that identifies genome-wide DNA binding sites for transcription factors and other proteins http://www.bioassayontology.org/bao#BAO_0010036 epigenetic profiling assay http://www.bioassayontology.org/bao#BAO_0010031 epigenetic assay Assays that are used to capture the genome-wide epigenetic modifications in a cell http://www.bioassayontology.org/bao#BAO_0010037 Bisulfite Sequencing assay http://www.bioassayontology.org/bao#BAO_0010036 epigenetic profiling assay An assay that is used to determine themethylation marks in a cells genome http://www.bioassayontology.org/bao#BAO_0010038 ATAC-seq epigenetic profiling assay http://www.bioassayontology.org/bao#BAO_0010036 epigenetic profiling assay ATAC-seq (assay for transposase-accessible chromatin using sequencing) is an assay that identifies open-chromatin sites on the whole genome level by using theTn5 transposase, which inserts sequencing adapters into accessible regions of chromatin http://www.bioassayontology.org/bao#BAO_0010039 global chromatin epigenetic profiling assay http://www.bioassayontology.org/bao#BAO_0010036 epigenetic profiling assay A mass spectrometry-based assay that is used to identify and quantify post-translational modifications on histone proteins from bulk chromatin http://www.bioassayontology.org/bao#BAO_0010040 metabolomic assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay Assays that identify and quantify cell metabolites (metabolic analytes) http://www.bioassayontology.org/bao#BAO_0010042 metabolomic profiling assay http://www.bioassayontology.org/bao#BAO_0010040 metabolomic assay Assays that profile key metabolomic parameters http://www.bioassayontology.org/bao#BAO_0010043 Cellarium metabolomic profiling assay http://www.bioassayontology.org/bao#BAO_0010042 metabolomic profiling assay A high throughput live-cell microarray screening assay that is used to detect metabolic analytes such as oxygen, pH and glucose at the single-cell level http://www.bioassayontology.org/bao#BAO_0010046 L1000 mRNA profiling assay http://www.bioassayontology.org/bao#BAO_0002995 transcriptional profiling assay L1000 is a bead-based, high-throughput gene expression assay in which cultured cells are treated with various chemical and genetic perturbations and the corresponding transcriptional responses are measured http://www.bioassayontology.org/bao#BAO_0010047 Nanostring http://www.bioassayontology.org/bao#BAO_0002995 transcriptional profiling assay An assay that uses barcoded hybridization probes to quantify the expression of RNA transcripts http://www.bioassayontology.org/bao#BAO_0010048 Microarray http://www.bioassayontology.org/bao#BAO_0002995 transcriptional profiling assay An array based method that simultaneously measures the expression of tens of thousands of RNA transcripts http://www.bioassayontology.org/bao#BAO_0010067 Protein-Protein NanoBRET Assay http://www.bioassayontology.org/bao#BAO_0002990 protein-protein interaction assay A variant of the BRET assay utilizing Nanoluc luciferace, providing higher stability, smaller size, greater separation of donor and acceptor wavelengths, and higher fluorescence intensity, enabling more accurate and precise quantification of protein-protein interactions http://www.bioassayontology.org/bao#BAO_0010068 Protein-Small Molecule NanoBRET Assay http://www.bioassayontology.org/bao#BAO_0000110 protein-small molecule interaction assay A variant of the BRET assay utilizing Nanoluc luciferace, providing higher stability, smaller size, greater separation of donor and acceptor wavelengths, and higher fluorescence intensity, enabling more accurate and precise quantification of protein-small molecule interactions http://www.bioassayontology.org/bao#BAO_0010069 Kinase NanoBRET Assay http://www.bioassayontology.org/bao#BAO_0010068 Protein-Small Molecule NanoBRET Assay A specific application of protein-small molecule NanoBRET examining the interaction of small molecules with specific kinases http://www.bioassayontology.org/bao#BAO_0010078 Arrestin2 recruitment assay http://www.bioassayontology.org/bao#BAO_0010077 GPCR Signaling A variant of a BRET assay wherein fluorescently tagged beta-arrestin2 is detected when in proximity of a G-protein coupled receptor with an Rluc C-terminal tag. http://www.bioassayontology.org/bao#BAO_0010079 PRESTO-TANGO http://www.bioassayontology.org/bao#BAO_0010078 Arrestin2 recruitment assay Beta-arrestin2 fused to the TEV protease liberates a tTA molecule fused to the C-terminus of a target G-protein coupled receptor when in close proximity, resulting in a tTA-driven expression of RLuc from a genomic TETO7-RLuc locus. http://www.bioassayontology.org/bao#BAO_0010080 Heterotrimeric G-protein dissassociation assay http://www.bioassayontology.org/bao#BAO_0002990 protein-protein interaction assay Measure release of the heterotrimeric G-protein complex from G-protein coupled receptors (GPCRs). When activated GPCRs catalyze the exchange of GDP for GTP in the G-alpha subunit of the Galpha-beta-gamma heterotrimeric complex, resulting in the disassociation of these subunits from the GPCR of interest. http://www.bioassayontology.org/bao#BAO_0010081 TRUPath http://www.bioassayontology.org/bao#BAO_0010080 Heterotrimeric G-protein dissassociation assay Measures heterotrimer G-protein disassociation using BRET between alpha and gamma subunits. http://www.bioassayontology.org/bao#BAO_0013016 functional target-based http://www.bioassayontology.org/bao#BAO_0000010 functional An assay where the measure signal is a direct or coupled readout of the proteins native mechanistic or conformational cycle. This can include: (1) assays that directly or indirectly measure product of an enzymatic cycle (e.g.: NADPH consumption, antibody based detection of phosphorylated peptide substrate, mass spec product detection and quantitation, electrofluidic mobility shift assay, etc); (2) assays that directly or indirectly measure the transmission of signal as a result of the interaction with a membrane bound receptor detected through fluorescent dye that detects the release of intracellular calcium, nuclear receptor, and (3) biochemical assays that measures the increase or decrease of an RNA transcript as a result of interaction with a nuclear receptor http://www.bioassayontology.org/bao#BAO_0013017 functional phenotypic http://www.bioassayontology.org/bao#BAO_0000010 functional An assay where the measured signal is a phenotypic response of the system or the readout is indirect (e.g. comparing cell survival between wildtype and mutant protein). http://www.bioassayontology.org/bao#BAO_0020003 plasma format http://www.bioassayontology.org/bao#BAO_0000366 cell-free format Plasma is the liquid part of the blood and lymphatic fluid, which makes up about half of the volume of blood. Plasma is devoid of cells and, unlike serum, has not clotted. http://www.bioassayontology.org/bao#BAO_0020004 serum format http://www.bioassayontology.org/bao#BAO_0000366 cell-free format Serum is the clear cell-free liquid that is separated from clotted blood. Serum differs from plasma in that the blood is first allowed to clot before centrifugation (separating from cells) while plasma preparations entail preventing blood clotting. Both are cell-free and contain antibodies. http://www.bioassayontology.org/bao#BAO_0040004 image resize http://www.bioassayontology.org/bao#BAO_0040002 image correction Image resize is a process to change the size of the image data by increasing or decreasing the number of pixels within the image. Mostly used for reducing in either the horizontal or vertical dimension. http://www.bioassayontology.org/bao#BAO_0040005 image sharpening http://www.bioassayontology.org/bao#BAO_0040002 image correction Image sharpening is a process to enhance the definition of object edges in an image. http://www.bioassayontology.org/bao#BAO_0040006 image smoothing http://www.bioassayontology.org/bao#BAO_0040002 image correction Image smoothing is a set of local pre-processing methods designed to suppress image noise. http://www.bioassayontology.org/bao#BAO_0040009 image thresholding http://www.bioassayontology.org/bao#BAO_0040007 image segmentation Image thresholding is a procedure that eliminates shades of gray from regions of an image above or below particular gray levels, replacing them instead with solid white or black. http://www.bioassayontology.org/bao#BAO_0040011 molecular abundance method http://www.bioassayontology.org/bao#BAO_0002202 assay design method Any method that simply measures the overall abundance (concentration, relative amount, etc) of a particular molecule (lipids, second messenger, nucleic acid, protein, etc.) http://www.bioassayontology.org/bao#BAO_0040012 second messenger abundance http://www.bioassayontology.org/bao#BAO_0040011 molecular abundance method Second messengers relay and amplify signals from receptors to the cell interior as part of a signaling event. Examples include cAMP, cGMP, calcium, nitric oxide, diacylglycerol, etc. Levels of these second messengers are measured to reflect strength of the signaling. http://www.bioassayontology.org/bao#BAO_0040013 lipid abundance method http://www.bioassayontology.org/bao#BAO_0040011 molecular abundance method Measuring lipid abundance could include mass spec-based methods and lipid droplet formation, a fluorescent intensity+image analysis assay to measure lipid stored in droplets within a cell, http://www.bioassayontology.org/bao#BAO_0040015 cell density determination http://www.bioassayontology.org/bao#BAO_0000127 viability measurement method Cell density, typically measured by absorbance (often indicated as A600 or OD600), is often used for bacterial or fungal cultures as an indication of cell number, viability or proliferation. http://www.bioassayontology.org/bao#BAO_0040016 Beta-galactosidase activity measurement method http://www.bioassayontology.org/bao#BAO_0000139 direct enzyme activity measurement method Beta-galactosidase activity measurement method http://www.bioassayontology.org/bao#BAO_0040017 DNA or RNA abundance method http://www.bioassayontology.org/bao#BAO_0040011 molecular abundance method Any method that simply measures the overall abundance (concentration, relative amount, etc) of a nucleic acid (DNA or RNA), typically via hybridization methods http://www.bioassayontology.org/bao#BAO_0040018 small molecule abundance method http://www.bioassayontology.org/bao#BAO_0040011 molecular abundance method Any method that simply measures the overall abundance (concentration, relative amount, etc) of a small molecule, such as LC-MS/MS or LC-UV. Typically used in both in vitro and in vivo ADME assays to monitor compound. http://www.bioassayontology.org/bao#BAO_0040019 cellular morphology assessment method http://www.bioassayontology.org/bao#BAO_0000448 morphology assessment method Any method that measures the size and shape of whole cells. Typically detected by microscopy or flow cytometry http://www.bioassayontology.org/bao#BAO_0040020 sub-cellular morphology assessment method http://www.bioassayontology.org/bao#BAO_0000448 morphology assessment method Any method that measures the size and shape of structures or organelles within cells, such as nuclei, mitochindria, Golgi, ER or vesicles. Typically detected by microscopy or flow cytometry http://www.bioassayontology.org/bao#BAO_0040021 in vivo assay method http://www.bioassayontology.org/bao#BAO_0002202 assay design method Any study performed in a whole, living organism (usually an animal such as a mouse or rat). http://www.bioassayontology.org/bao#BAO_0040022 in vivo efficacy method http://www.bioassayontology.org/bao#BAO_0040021 in vivo assay method Any study performed in a whole, living organism (usually an animal such as a mouse or rat), to test the effects of a treatment on a specific disease modeled in this animal. Study design and measured endpoints vary tremendously and depend on the particular aspects of the targeted disease. Ideally, the endpoints measured will correlate with how efficacy would be measured in humans. http://www.bioassayontology.org/bao#BAO_0040023 in vivo PK/PD/Tox method http://www.bioassayontology.org/bao#BAO_0040021 in vivo assay method Any study performed in a whole, living organism (usually an animal such as a mouse or rat) to investigate the pharmacokinetics (PK), pharmacodynamics (PD) or toxicity of a perturbagen or treatment. http://www.bioassayontology.org/bao#BAO_0040024 thermal shift assessment method http://www.bioassayontology.org/bao#BAO_0000123 binding assessment method Changes in protein thermal stability can be induced by ligand binding, and this thermodynamic stabilization can be measured by a variety of methods, often reported as a delta Tm (or change in the melting temperature of the protein). http://www.bioassayontology.org/bao#BAO_0040025 chemiluminescent labeling method http://www.bioassayontology.org/bao#BAO_0002452 labeling method A method that uses chemilumiscence to quantify the labeled entity. For this, an enzyme converts a substrate to a product that emits photons of light http://www.bioassayontology.org/bao#BAO_0040026 dna-seq method http://www.bioassayontology.org/bao#BAO_0002447 nucleic acid sequencing method A method that is used to identify the precise order/sequence of the nucleotides in a dna molecule by using the shotgun method in which DNA is fragmented and then the individual frgaments are sequenced http://www.bioassayontology.org/bao#BAO_0040027 chromatin acessibility method http://www.bioassayontology.org/bao#BAO_0002202 assay design method A method that is used to identify open / accessible genomic sites of remodeled chromatin http://www.bioassayontology.org/bao#BAO_0040028 metabolite abundance method http://www.bioassayontology.org/bao#BAO_0040011 molecular abundance method A method that is used to quantify various cell metabolites or metabolism-related analytes (e.g. O2, glucose, pH) http://www.bioassayontology.org/bao#BAO_0040030 transcription factor occupancy http://www.bioassayontology.org/bao#BAO_0040027 chromatin acessibility method A method that is used to identify the DNA regions that are being occupied by a predefined transcriptional factor(s) http://www.bioassayontology.org/bao#BAO_0040031 size separation method http://www.bioassayontology.org/bao#BAO_0002202 assay design method Techniques used to separate mixtures of macromolecules based on physical size and mass http://www.bioassayontology.org/bao#BAO_0050002 visual observation method http://www.bioassayontology.org/bao#BAO_0000035 physical detection method Any method entailing primarily routine examination, requiring no special instrumentation. http://www.bioassayontology.org/bao#BAO_0050003 simple measurement method http://www.bioassayontology.org/bao#BAO_0000035 physical detection method Any method entailing basic measurements that require no special instrumentation. Examples are measuring a tumor size using calipers, or a subject's weight using a scale. http://www.bioassayontology.org/bao#BAO_0070002 Tox21 Compound Library http://www.bioassayontology.org/bao#BAO_0000648 compound library The Tox21 compound collection is a library of approximately 10,000 (10K) environmental chemicals and drugs (~10,500 chemicals (~8,300 unique)), also referred to as the 'Tox21 10K library'. Several publications, from NCATS and EPA. See also https://www.epa.gov/chemical-research/toxicology-testing-21st-century-tox21 or https://ncats.nih.gov/tox21/about/operations. http://www.bioassayontology.org/bao#BAO_0080016 TC50 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint The concentration of compound required to kill 50% of a cell population (i.e., 50% inhibitory concentration in a cytotoxicity assay). http://www.bioassayontology.org/bao#BAO_0080017 TCID50 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint 50% Tissue Culture Infective Dose (TCID50) is the measure of infectious virus titer. This endpoint dilution assay quantifies the amount of virus required to kill 50% of infected hosts or to produce a cytopathic effect in 50% of inoculated tissue culture cells. http://www.bioassayontology.org/bao#BAO_0080023 binary unit http://www.bioassayontology.org/bao#BAO_0000077 unit of measurement A simple binary assessment, such as 'active/ inactive', 'true/ false', etc. http://www.bioassayontology.org/bao#BAO_0080024 binary endpoint http://www.bioassayontology.org/bao#BAO_0080045 categorical endpoint Any result reported as a simple binary assessment, such as 'active/ inactive', 'true/ false', etc. http://www.bioassayontology.org/bao#BAO_0080034 beta-arrestin clustering assay http://www.bioassayontology.org/bao#BAO_0000110 protein-small molecule interaction assay The Transfluor assay employs a a beta-arrestin-GFP fusion protein to detect activation of GPCRs: Upon ligand binding the GPCR, cytosolic arrestin-GFP quickly translocates to the cell membrane and then to endocytic vesicles, where it 'clusters' and can be detected by fluorescent image analysis. (Developed / commercialized by Norak, then Molecular Devices) http://www.bioassayontology.org/bao#BAO_0080037 Emax http://www.bioassayontology.org/bao#BAO_0002118 graphical calculation endpoint Maximum induction effect (dimensionless) http://www.bioassayontology.org/bao#BAO_0080038 molar attenuation coefficient http://www.bioassayontology.org/bao#BAO_0002128 physical property endpoint This is a measurement of how strongly a chemical species attenuates light at a given wavelength. Common units are L/(mol*cm). http://www.bioassayontology.org/bao#BAO_0080039 max fold increase http://www.bioassayontology.org/bao#BAO_0000193 fold change The maximum observed fold increase. http://www.bioassayontology.org/bao#BAO_0080040 fraction unbound http://www.bioassayontology.org/bao#BAO_0002128 physical property endpoint The fraction of compound that does not bind to substrate (e.x. plasma proteins) http://www.bioassayontology.org/bao#BAO_0080041 cell count http://www.bioassayontology.org/bao#BAO_0000583 raw activity Count of cells as an endpoint http://www.bioassayontology.org/bao#BAO_0080042 ratio endpoint http://www.bioassayontology.org/bao#BAO_0000179 endpoint A ratio endpoint is the relative relation between two quantitative results (a/b) http://www.bioassayontology.org/bao#BAO_0080043 blood to plasma ratio http://www.bioassayontology.org/bao#BAO_0080042 ratio endpoint The ratio of the concentration of molecule in whole blood (i.e. contains both red blood cells and plasma) to the concentration of molecule in plasma, namely CB/CP. http://www.bioassayontology.org/bao#BAO_0080044 AC50 Ratio http://www.bioassayontology.org/bao#BAO_0080042 ratio endpoint Ratio of AC50 values http://www.bioassayontology.org/bao#BAO_0080045 categorical endpoint http://www.bioassayontology.org/bao#BAO_0000179 endpoint A categorical endpoint is any result that can take one of a limited number of possible values. http://www.bioassayontology.org/bao#BAO_0140009 CytoTox-Glo (Promega) http://www.bioassayontology.org/bao#BAO_0140017 Luciferase-based ('Glo') Assay System (Promega) CytoTox-Glo Cytotoxicity Assay (Promega) uses a luminogenic peptide substrate of luciferase, the AAF-Glo Substrate, to measure dead-cell protease activity, which is released from cells that have lost membrane integrity. http://www.bioassayontology.org/bao#BAO_0140010 CAT ELISA (Roche/ Sigma-Aldrich) http://www.bioassayontology.org/bao#BAO_0000248 assay kit The CAT ELISA is used to quantitatively measure CAT expression in eukaryotic cells that are transfected with a plasmid bearing a CAT-encoding reporter gene. http://www.bioassayontology.org/bao#BAO_0140011 ACTOne cAMP biosensor assay (BD Biosciences; CodexBIosolutions) http://www.bioassayontology.org/bao#BAO_0000248 assay kit This assay directly measures the intracellular concentration of the second messenger cAMPin living cells, in real-time. It works with cell lines that contain a proprietary exogenous Cyclic Nucleotide-Gated (CNG) channel (BD Biosciences, sold to CodexBiosolutions; both in Maryland). The channel is activated by elevated intracellular levels of cAMP, resulting in ion flux (detectable by calcium-responsive dyes) and cell membrane depolarization which can be detected with a fluorescent membrane potential (MP) dye. http://www.bioassayontology.org/bao#BAO_0140012 CellTiter-Blue Cell Viability Assay (Promega) http://www.bioassayontology.org/bao#BAO_0000248 assay kit The CellTiter-Blue Cell Viability Assay provides a homogeneous, fluorescent method for monitoring cell viability. The assay is based on the ability of living cells to convert a redox dye (resazurin) into a fluorescent end product (resorufin) http://www.bioassayontology.org/bao#BAO_0140013 Gal-Screen Beta-Galactosidase Reporter Gene Assay system http://www.bioassayontology.org/bao#BAO_0000248 assay kit The Gal-Screen assay system combines direct cell lysis with rapid, ultra-sensitive chemiluminescent detection of _-galactosidase reporter enzyme. http://www.bioassayontology.org/bao#BAO_0140014 QuantiTect SYBR Green PCR Kits (Qiagen/Thermo-Fisher) http://www.bioassayontology.org/bao#BAO_0000248 assay kit Real-time PCR (or RT-PCR) for quantitation of DNA (or RNA, respectively) using the fluorescent dye SYBR green that binds dsDNA and emits fluorescence only when bound. http://www.bioassayontology.org/bao#BAO_0140015 TaqMan Real-Time PCR assays (Thermo-Fisher) http://www.bioassayontology.org/bao#BAO_0000248 assay kit Real-time PCR (or RT-PCR) for quantitation of DNA (or RNA, respectively) using a pair of unlabeled PCR primers and a 'TaqMan' fluorogenic probe labeled on the 5' end and minor groove binder (MGB) and nonfluorescent quencher (NFQ) on the 3' end, to detect target as it accumulates during PCR. http://www.bioassayontology.org/bao#BAO_0140016 Ultra-Glo Luciferin Detection (Promega) http://www.bioassayontology.org/bao#BAO_0140017 Luciferase-based ('Glo') Assay System (Promega) Ultra-Glo (Promega) is a thermostable recombinant luciferase that can be coupled with different luciferin-based substrates to generate a luminescent signal proportional to the substrate abundance. http://www.bioassayontology.org/bao#BAO_0140017 Luciferase-based ('Glo') Assay System (Promega) http://www.bioassayontology.org/bao#BAO_0000248 assay kit An assay system (Promega) based on the bioluminescent enzyme luciferase's catalysis of the substrate luciferin to generate light, adapted for multiple applications, such as cell viability, apoptosis, or kinase, cytochrome P450, or proteasome activity. http://www.bioassayontology.org/bao#BAO_0140018 WST-1 assay (Roche) http://www.bioassayontology.org/bao#BAO_0000248 assay kit A colorimatric assay for cell viability/ proliferation based on the stable tetrazolium salt WST-1, which is cleaved to a soluble formazan by a complex cellular mechanism that occurs primarily at the cell surface. This bioreduction is largely dependent on the glycolytic production of NAD(P)H in viable cells. http://www.bioassayontology.org/bao#BAO_0140020 Alpha Screen Assay Kit (PerkinElmer) http://www.bioassayontology.org/bao#BAO_0000248 assay kit A homogeneous bead-based proximity assay (alpha = 'amplified luminescent proximity homogeneous assay'). Binding of molecules captured on donor and acceptor beads leads to an energy transfer from one bead to the other, ultimately producing a luminescent/fluorescent signal. Ligands on the bead allow for detection of many different types of molecules. http://www.bioassayontology.org/bao#BAO_0140022 Human Cytochrome c ELISA (R&D Systems) http://www.bioassayontology.org/bao#BAO_0000248 assay kit A solid phase sandwich ELISA to meaasure human cytochrome c in cell lysates http://www.bioassayontology.org/bao#BAO_0140024 TRANSCREENER ADP2 FP Kinase Assay (BellBrook Labs) http://www.bioassayontology.org/bao#BAO_0000248 assay kit A fluorescence polarization (FP) assay that uses an antibody against ADP and a tracer to measure the progress of any enzyme that produces ADP http://www.bioassayontology.org/bao#BAO_0140025 Polar Screen PPARg Competitor Assay, Green (Invitrogen) http://www.bioassayontology.org/bao#BAO_0000248 assay kit A fluorescence polarization (FP) assay. http://www.bioassayontology.org/bao#BAO_0140026 QUANTI-Blue (InvivoGen) http://www.bioassayontology.org/bao#BAO_0000248 assay kit QUANTI-Blue is a colorimetric enzyme assay to measure alkaline phosphatase activity. http://www.bioassayontology.org/bao#BAO_0140027 ToxiLight BioAssay Kit (Lonza) http://www.bioassayontology.org/bao#BAO_0000248 assay kit The ToxiLighte BioAssay Kit is a bioluminescent cytolysis assay kit that measures release of the enzyme, adenylate kinase (AK), from damaged cells. http://www.bioassayontology.org/bao#BAO_0140028 TransAM Kit for NF-kB Family (Active Motif) http://www.bioassayontology.org/bao#BAO_0000248 assay kit TransAM Kits are DNA-binding ELISAs that facilitate the study of transcription factor activation in mammalian tissue and cell extracts. http://www.bioassayontology.org/bao#BAO_0140029 TRANSCREENER AMP2/GMP2 FP Assay (BellBrook Labs) http://www.bioassayontology.org/bao#BAO_0000248 assay kit A fluorescence polarization (FP) assay that uses an antibody against AMP or GMP and a tracer to measure the progress of any enzyme that produces AMP or GMP http://www.bioassayontology.org/bao#BAO_0140030 Caspase-Glo 6 Assay System (Promega) http://www.bioassayontology.org/bao#BAO_0140017 Luciferase-based ('Glo') Assay System (Promega) A homogeneous, bioluminescent assay to measure caspase-6 activity. http://www.bioassayontology.org/bao#BAO_0140031 CDP-Star alkaline phosphatase assay system http://www.bioassayontology.org/bao#BAO_0000248 assay kit CDP-Star is a chemiluminescent substrate of alkaline phosphatase, compatible with both membrane- and solution-based assays. Sold by multiple vendors. http://www.bioassayontology.org/bao#BAO_0140032 Sensolyte 520 HCV Protease Assay Kit (AnaSpec) http://www.bioassayontology.org/bao#BAO_0000248 assay kit An assay kit for measuring hepatitits C virus (HCV) NS3/4A protease activity using a 5-FAM/QXL520 fluorescence resonance energy transfer (FRET) peptide. Called 'Enzolyte' as well as 'Sensolyte'. http://www.bioassayontology.org/bao#BAO_0140033 EnzyChrom Aspartate Transaminase Assay Kit (BioAssay Systems) http://www.bioassayontology.org/bao#BAO_0000248 assay kit An absorbance-based assay system for measuring aspartate transaminase (known as serum glutamic oxaloacetic transaminase (GOT) or aspartate aminotransferase (ASAT/AAT)), based on the quantification of oxaloacetate produced by AST. In this assay, oxaloacetate and NADH are converted to malate and NAD by the enzyme malate dehydrogenase. The decrease in NADH absorbance at 340 nm is proportionate to AST activity. http://www.bioassayontology.org/bao#BAO_0140034 FluoZin-2 AM fluorescent assay of zinc concentration http://www.bioassayontology.org/bao#BAO_0000248 assay kit FluoZin-2 AM is a cell-permeant (acetoxymymethyl (AM)) fluorescent indicator designed to detect Zn2+ concentrations that are present in synaptic vesicles and released in response to electrical stimulation or excitotoxic agonists. (Sold by Molecular Probes, Themro-Fisher) http://www.bioassayontology.org/bao#BAO_0140035 Phospho-ERK1/2 (Thr202/Tyr204) Cellular Assay Kit (Cisbio) http://www.bioassayontology.org/bao#BAO_0000248 assay kit This homogeneous (HTRF) phospho-ERK assay is based on a TR-FRET sandwich immunoassay format comprising two specific monoclonal anti-pERK1/2 antibodies (recognizing the phosphorylated residue (Thr202/Tyr204), one labeled with Eu3+-cryptate (donor) and the other labeled with d2 (acceptor). The proximity of donor and acceptor leads to a fluorescent TR-FRET signal; the signal intensity is proportional to the substrate phosphorylation. Also called 'HTRF Cellul'ERK Kit'. http://www.bioassayontology.org/bao#BAO_0140036 IMAP Assay of phosphoproteins (Molecular Devices) http://www.bioassayontology.org/bao#BAO_0000248 assay kit IMAP (Immobilized Metal Ion Affinity Particle) technology is a non-antibody-based assay for protein kinases in which a fluorescently labeled peptide substrate that is phosphorylated by a kinase is captured on trivalent metal-containing nanoparticles. IMAP can be adapted for either FP or TR-FRET detection. http://www.bioassayontology.org/bao#BAO_0140037 insulin ELISA kit (Alpco) http://www.bioassayontology.org/bao#BAO_0000248 assay kit This Insulin ELISA kit is an FDA registered in vitro diagnostic tool for the quantification of human insulin. It uses a dual-monoclonal antibody sandwich ELISA format, typically in a 96-well or other microplate format, with colorimetric (OD 450 nm) detection. http://www.bioassayontology.org/bao#BAO_0140038 LanthaScreen Tb-Ubiquitin Assay http://www.bioassayontology.org/bao#BAO_0000248 assay kit An assay to monitor protein ubiquitination, using ubiquitin labeled with the LanthaScreen terbium chelate, in combination with a FRET acceptor such as fluorescein-ubiquitin or a fluorescein-labeled antibody. http://www.bioassayontology.org/bao#BAO_0140039 LanthaScreen Tb-Streptavidin Binding Assay http://www.bioassayontology.org/bao#BAO_0000248 assay kit A terbium-labeled streptavidin used in combination with a fluorescent molecule to detect interaction via a TR-FRET assay. http://www.bioassayontology.org/bao#BAO_0140040 PathHunter U2OS Keap1-NRF2 Nuclear Translocation Assay (DiscoverX) http://www.bioassayontology.org/bao#BAO_0000248 assay kit An assay system employing enzyme fragment complementation (two fragments of the beta-galactosidase enzyme), applied in U2OS cells engineered to express two appropriately tagged proteins. Inhibition of Keap1-NRF2 interaction results in Nrf2 nuclear translocation, and susbequent complementation and formation of a functional enzyme, detected using a chemiluminescent substrate of beta-galactosidase. http://www.bioassayontology.org/bao#BAO_0140041 qScript One-step Fast qRT-PCR kit (QuantaBioSciences) http://www.bioassayontology.org/bao#BAO_0000248 assay kit A general kit for use in all types of qRT-PCR reactions http://www.bioassayontology.org/bao#BAO_0140042 Renilla-Glo luciferase assay system (Promega) http://www.bioassayontology.org/bao#BAO_0140017 Luciferase-based ('Glo') Assay System (Promega) A bioluminescent assay sytem for detecting sea pansy (Renilla reniformis) luciferase, an alternative to the firefly (Photinus pyralis) systems. http://www.bioassayontology.org/bao#BAO_0140043 Ub-CHOP2-Reporter-Kit (LifeSensors Inc.) http://www.bioassayontology.org/bao#BAO_0000248 assay kit An assay for deubiquitination activity, employing a reporter enzyme fused to ubiquitin (making the reporter catalytically inactive). Following cleavage of the Ub-reporter system by the isopeptidase, the free reporter can act upon its fluorescent substrate. http://www.bioassayontology.org/bao#BAO_0140046 CellTiter-Fluor Cell Viability Assay Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit The CellTiter-Fluor Cell Viability Assay measures the relative number of viable cells in a population. The assay is based on measurement of a conserved and constitutive protease activity within live cells and therefore serves as a biomarker of cell viability. The live-cell protease activity is restricted to intact viable cells and is measured using a fluorogenic, cell-permeant, peptide substrate (Gly-Phe-AFC). The substrate enters intact cells, where it is cleaved by the live-cell protease activity to generate a fluorescent signal proportional to the number of living cells. The live-cell protease becomes inactive upon loss of membrane integrity and leakage into the surrounding culture medium. (description adapted from vendor Promega) http://www.bioassayontology.org/bao#BAO_0150052 IonWorks automated electrophysiology system (Molecular Devices) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument Automated patch clamp systems for ion channel research http://www.bioassayontology.org/bao#BAO_0150053 Analyst AD (Molecular Devices) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument Assay development system (plate-reader) with four modes: fluorescence, luminescence, absorbance, and Epi-absorbance (Molecular Devices) http://www.bioassayontology.org/bao#BAO_0150054 Axopatch 200B amplifier (Molecular Devices) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument An instument for single-channel recoding and whole-cell voltage-clamp recording (Axon Instruments/ Molecular Devices) http://www.bioassayontology.org/bao#BAO_0150055 Becton Dickinson (BD) LSRII FACS http://www.bioassayontology.org/bao#BAO_0000697 detection instrument The BD LSRII FACS is an air-cooled multi-laser benchtop flow cytometer. http://www.bioassayontology.org/bao#BAO_0150056 Synergy 2 Multi-Mode Reader (BioTek) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument The Synergy 2 Multi-Mode Plate Reader's (BioTek) detection modes include fluorescence intensity, fluorescence polarization, time-resolved fluorescence, AlphaScreen, luminescence and UV-visible absorbance. http://www.bioassayontology.org/bao#BAO_0150057 BMG PHERAstar FSX plate reader (BMG Labtech, Cary NC) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument BMG PHERAstar is a multi-mode benchtop plate reader; FSX and other models (BMG Labtech) http://www.bioassayontology.org/bao#BAO_0150058 Countess automatic cell counter http://www.bioassayontology.org/bao#BAO_0000697 detection instrument An automated cell counting device: Countess; Countes II FL has fluorescence capabilites (Invitrogen/ ThermoFisher) http://www.bioassayontology.org/bao#BAO_0150059 FacSCAN flow cytometer http://www.bioassayontology.org/bao#BAO_0000697 detection instrument A flow cell_based benchtop cytometer (Becton Dickinson (BD)) http://www.bioassayontology.org/bao#BAO_0150060 Molecular Devices Vmax plate reader http://www.bioassayontology.org/bao#BAO_0000697 detection instrument A filter-based absorbance platereader for kinetic and endpoint assays (Molecualr Devices) http://www.bioassayontology.org/bao#BAO_0150061 Molecular Devices SpectraMax Plate reader http://www.bioassayontology.org/bao#BAO_0000697 detection instrument Several models of UV-visible absorbance microplate readers: SpectraMax 190; SpectraMax Plus 384; SpectraMax 340PC384 (Molecular Devices) http://www.bioassayontology.org/bao#BAO_0150062 Qpatch automated patch clamp system (Biolin) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument Several models of automated patch clamp systems for studying ion channels: QPatch8, QPAtch16, QpatchHT (Biolin Scientific) http://www.bioassayontology.org/bao#BAO_0150063 LightCycler 480 Real-Time PCR detection instrument http://www.bioassayontology.org/bao#BAO_0000697 detection instrument One of several models of a plate-based real-time PCR device (Roche ) http://www.bioassayontology.org/bao#BAO_0150064 Mx3005P RT-PCR instrument (Agilent Technologies) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument The Agilent Mx3005P QPCR System, a benchtop RT-PCR plate reader, has been replaced with the AriaMx system (Agilent Technologies) http://www.bioassayontology.org/bao#BAO_0150065 Synergy HT Multi-Mode Reader (BioTek) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument The Synergy HT (or HTX) is a Multi-Mode Plate Reader (BioTek) is a single-channel absorbance, fluorescence and luminescence microplate reader. http://www.bioassayontology.org/bao#BAO_0150066 GloMax luminometer (Promega) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument One of several models of luminometer, either single-tube to multiple plate readers (Promega). Some models are multimode and can also read fluorescence or absorbance in addition to luminescence ) http://www.bioassayontology.org/bao#BAO_0150067 LTQ-Orbitrap Velos (Thermo Scientific) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument A mass spectrometer http://www.bioassayontology.org/bao#BAO_0150068 Appled Biosystems Real-Time PCR System (ThermoFisher) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument Encompasses various models--ABI-9300, ABI-7500, and QuantStudio. http://www.bioassayontology.org/bao#BAO_0150069 Agilent 1100 series LC-MSD SL http://www.bioassayontology.org/bao#BAO_0000697 detection instrument A mass spectrometer http://www.bioassayontology.org/bao#BAO_0150071 micro-Quant Plate Reader (BioTek) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument A microplate spectrophotometer http://www.bioassayontology.org/bao#BAO_0150081 Typhoon Trio variable-mode imager (Amersham/ GE LifeSciences) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument A laser-based scanner that produces digital images of radioactive, fluorescent, or chemiluminescent samples http://www.bioassayontology.org/bao#BAO_0150083 xCELLigence RTCA DP cellular impedance instrument (Acea Biosciences) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument The xCELLigence RTCA DP instrument uses noninvasive electrical impedance monitoring to quantify cell proliferation, morphology change, and attachment quality in a label-free, real-time manner. http://www.bioassayontology.org/bao#BAO_0150085 Biacore 3000 SPR System (GE Healthcare) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument One of several models of surface plasmon resonance (SPR) instruments. http://www.bioassayontology.org/bao#BAO_0150086 ChemiDoc XRS Imaging System (BioRad) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument Imaging system based on CCD high-resolution detection, supports multiple detection methods including fluorescence, colorimetry, densitometry, chemiluminescence, and chemifluorescence. http://www.bioassayontology.org/bao#BAO_0150090 Storm PhosphorImager (Molecular Dynamics/ GE) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument An imaging system for blots, gels, etc, to replace use of film; can be used for autoradiography, fluorescence, and chemifluorescence imaging. http://www.bioassayontology.org/bao#BAO_0150095 Luminex 200 Flow Cytometer http://www.bioassayontology.org/bao#BAO_0000697 detection instrument The Luminex 100/200 System is the combination of three core xMAP® Technologies. The first is xMAP microspheres, a family of fluorescently dyed micron-sized polystyrene microspheres that act as both the identifier and the solid surface to build the assay. The second is a flow cytometry-based instrument, the Luminex 100/200 analyzer, which integrates key xMAP detection components, such as lasers, optics, fluidics, and high-speed digital signal processors. The third component is the xPONENT® software, which is designed for protocol-based data acquisition with robust data regression analysis. From https://www.luminexcorp.com/research-luminex-100200/ http://www.bioassayontology.org/bao#BAO_0170001 molecular phenotype http://www.bioassayontology.org/bao#BAO_0002542 cell phenotype The molecular characteristics of a cell of tissue including expressed coding and non-coding RNAs, proteins and their post-translational modifications, lipids, carbohydrates and small molecules that characterize the state in a cell or tissue and that result from the interaction of its genotype and the environment. http://www.bioassayontology.org/bao#BAO_0170003 biochemical phenotype http://www.bioassayontology.org/bao#BAO_0170001 molecular phenotype The proteins and their post-translational modifications, lipids, carbohydrates and small molecules that characterize the state in a cell or tissue and that result from the interaction of its genotype and the environment. http://www.bioassayontology.org/bao#BAO_0170004 transcriptional phenotype http://www.bioassayontology.org/bao#BAO_0170001 molecular phenotype The coding and non-coding RNAs expressed in a cell or tissue that result from the interaction of its genotype and the environment. http://www.bioassayontology.org/bao#BAO_0190000 concentration unit http://www.bioassayontology.org/bao#BAO_0000077 unit of measurement It describes the most common unit used in calculating volumetric stoichiometry: molarity. Units include: molar, millimolar, micromolar, nanomolar. http://www.bioassayontology.org/bao#BAO_0190004 pKi http://www.bioassayontology.org/bao#BAO_0002128 physical property endpoint Negative base-10 logarithm of KI, the equilibrium dissociation constant (Ki) of an antogonist-receptor complex http://www.bioassayontology.org/bao#BAO_0190005 pKd http://www.bioassayontology.org/bao#BAO_0002128 physical property endpoint Negative base-10 logarithm of a solution's KD (drug affinity dissociation constant) http://www.bioassayontology.org/bao#BAO_0190006 pKb http://www.bioassayontology.org/bao#BAO_0002128 physical property endpoint Negative base-10 logarithm of a solution's base dissociation constant (Kb) http://www.bioassayontology.org/bao#BAO_0200000 Illumina http://www.bioassayontology.org/bao#BAO_0002091 commercial company A biotechnology company that develops, manufactures, and markets integrated systems for the analysis of genetic variation and biological function. The company provides a line of products and services that serves the sequencing, genotyping, gene expression, and proteomics markets. Explanation: Not currently available as a commercial company, but well known and used in next-gen sequencing circles. http://www.bioassayontology.org/bao#BAO_0700003 bivalent small molecule-peptide http://www.bioassayontology.org/bao#BAO_0000076 screened entity A synthetic ligand consisting of a small molecule tethered (covalently or non-covalently) to a peptide. http://www.bioassayontology.org/bao#BAO_0700004 FDA-approved compound library http://www.bioassayontology.org/bao#BAO_0000648 compound library Any compound library consisting solely of small molecules that have been approved by the FDA. Often used for 'drug re-purposing' assays. The specific compounds included in any given FDA-approved compound library may differ based on availability or timing. http://www.bioassayontology.org/bao#BAO_0000692 Infinite F200 http://www.bioassayontology.org/bao#BAO_0000697 detection instrument Tecan Infinite F200 is a multifunctional microplate filter-based reader with injector option, that provides high performance for the vast majority of microplate applications and research. It has been designed as a general purpose laboratory instrument for professional use, supporting common 6 to 384-well microplates. (Manufacturer description) http://www.bioassayontology.org/bao#BAO_0000435 Hill equation http://www.bioassayontology.org/bao#BAO_0000625 curve fit model The Hill equation is commonly used to estimate the number of ligand molecules that are required to bind to a receptor to produce a functional effect. The Hill coefficient can be considered as an interaction coefficient, reflecting the extent of cooperativity among multiple ligand binding sites. http://www.bioassayontology.org/bao#BAO_0003035 MIC50 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint The lowest concentration of an antimicrobial agent required to inhibit the growth of 50% of organisms. http://www.bioassayontology.org/bao#BAO_0002880 AC35 absolute http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint The compound concentration at which the fitted curve passes activity threshold 35. http://www.bioassayontology.org/bao#BAO_0001043 university of pittsburgh molecular libraries screening center http://www.bioassayontology.org/bao#BAO_0000709 research institute It is an MLSCN (pilot phase) screening center. http://www.bioassayontology.org/bao#BAO_0000432 Z-score http://www.bioassayontology.org/bao#BAO_0002126 statistical endpoint Random and systematic error can induce either underestimation (false negatives) or overestimation (false positives) of measured signals. Z score indicates how many standard deviations an observation is above or below the mean. For calculating this, the average of the plate values is subtracted from individual raw values and the difference divided by the standard deviation estimated from all measurements of the plate. http://www.bioassayontology.org/bao#BAO_0000230 deleted http://www.bioassayontology.org/bao#BAO_0000643 mutated A quality of the genetic material (DNA or RNA) that harbors a change (mutation), where one or more nucleotides are lost (spontaneously) or removed (intentionally). http://purl.obolibrary.org/obo/DOID_0060903 thrombosis http://purl.obolibrary.org/obo/DOID_178 vascular disease A vascular disease caused by the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system. http://www.bioassayontology.org/bao#BAO_0000276 tRNA http://www.bioassayontology.org/bao#BAO_0000270 RNA tRNA or transfer RNA is a small RNA molecule that transfers a specific active amino acid to a growing polypeptide chain at the ribosomal site of protein synthesis. http://www.bioassayontology.org/bao#BAO_0000567 emission wavelength http://www.bioassayontology.org/bao#BAO_0000565 wavelength For fluorescence measurements, it is the wavelength at which an excited fluorophore emits fluorescence. http://purl.obolibrary.org/obo/DOID_0060904 legume allergy http://purl.obolibrary.org/obo/DOID_0060503 fruit allergy A fruit allergy triggered by Fabaceae (legume) plant fruit or seed food product. http://purl.obolibrary.org/obo/DOID_0111867 nonphotosensitive trichothiodystrophy http://purl.obolibrary.org/obo/DOID_0111866 trichothiodystrophy A trichothiodystrophy characterized by absence of extreme sensitivity to UV radiation. http://www.bioassayontology.org/bao#BAO_0000576 24 well plate http://www.bioassayontology.org/bao#BAO_0000508 microplate This microplate contains 24 wells. It is suitable for a low throughput assay. http://www.bioassayontology.org/bao#BAO_0000198 IC50 relative http://www.bioassayontology.org/bao#BAO_0000190 IC50 The concentration of a test substance that produces an inhibitory effect corresponding to 50% of the activity of that particular substance (i.e. 50% of the difference between top and bottom of fitted curve). It can also be described as the concentration corresponding to the inflection point of the curve. http://www.bioassayontology.org/bao#BAO_0000241 genetic modification method http://www.bioassayontology.org/bao#BAO_0000238 cell line modification method This refers to the introduction of cloned genes into cells by various methods, including transfection, transduction, electroporation, nucleofection, etc. It is generally performed to express the exogenously introduced gene and study its effect on the cell. In addition, DNA encoding regulatory moieties, such as siRNA is similarly introduced to inhibit the expression of a specific gene(s). http://www.bioassayontology.org/bao#BAO_0000153 fluorescent protein induction http://www.bioassayontology.org/bao#BAO_0000125 reporter gene method Fluorescent proteins are commonly used as reporter genes to study the effect of perturbagens on gene expression. Examples include green fluorescent protein (GFP) from the jellyfish Aequorea victoria and the various modifications of it created by amino acid substitutions to either optimize the codon usage in mammalian cells or to change the spectral properties of the protein. http://www.bioassayontology.org/bao#BAO_0000533 multiple repetition http://www.bioassayontology.org/bao#BAO_0002178 repetition throughput Regular high-throughput screening (primary screening) to identify hits. http://www.bioassayontology.org/bao#BAO_0002475 fluorescent intercalator displacement http://www.bioassayontology.org/bao#BAO_0002472 fluorescent DNA intercalation method The assay utilizes the displacement of ethidium bromide (or thiazole orange) from hairpin deoxyoligonucleotides. http://www.bioassayontology.org/bao#BAO_0000046 fluorescence method http://www.bioassayontology.org/bao#BAO_0000035 physical detection method Detection techniques that use the principles of fluorescence, whereby incident light excites a fluorophore which then emits light at lower energy (higher wavelength). The emitted light is typically from the visible portion of the UV-Visible spectrum. http://www.bioassayontology.org/bao#BAO_0002110 fluorescence microscope filter http://www.bioassayontology.org/bao#BAO_0003118 instrument This categorizes the devices that selectively transmit light in a particular range of wavelengths, including excitation and emission filters. For optimal results, the distance between the wavelengths of the excitation and emission filter should be more than 85% of the sum of both filters’ bandwidths. http://www.bioassayontology.org/bao#BAO_0000094 growth inhibition http://www.bioassayontology.org/bao#BAO_0000091 inhibition Growth reduction of a predefined stimulus. Unit of Measure is always % when normalized to the dynamic range of the assay. As a measure of viable or proliferating cells, different researchers measure different parameters, namely, protein content (by sulforhodamine B staining followed by absorbance measurement), mitochondrial dehydrogenase activity (by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrasodium bromide, known as MTT staining followed by absorbance measurement), expression of proliferation associated antigens (by immunostaining for Ki-67), and ATP content (by using CellTiter-Glo reagent (Promega) followed by luminescence measurement. http://www.bioassayontology.org/bao#BAO_0003024 gene expression detection method http://www.bioassayontology.org/bao#BAO_0002202 assay design method The technologies used to quantify the expression level of the entire gene pool in a cell or a subpopulation (e.g. tissue-specific gene expression, kinases pool, etc.) using one of the three methods, namely: microarray, bead based method or RNASeq. http://www.bioassayontology.org/bao#BAO_0002118 graphical calculation endpoint http://www.bioassayontology.org/bao#BAO_0000179 endpoint An endpoint derived from calculus-based analysis of graphical measures. http://www.bioassayontology.org/bao#BAO_0000287 hydrolase http://www.bioassayontology.org/bao#BAO_0000279 enzyme Formation of two products from a substrate by hydrolysis. http://www.bioassayontology.org/bao#BAO_0000564 multiplexed readout http://www.bioassayontology.org/bao#BAO_0002169 assay readout content It is a HTS assay, where the readout is measured from multiple targets from one well. E.g., several protein targets are detected simultaneously by using probes labeled with different fluorescent properties. http://www.bioassayontology.org/bao#BAO_0003037 Tmax http://www.bioassayontology.org/bao#BAO_0002114 time endpoint The time required for a drug to reach maximum concentration in plasma (Cmax) following administration. http://www.bioassayontology.org/bao#BAO_0170002 morphological phenotype http://www.bioassayontology.org/bao#BAO_0002542 cell phenotype The form and structure of an organism and its parts, including cells, that result from the interaction of its genotype and the environment. http://www.bioassayontology.org/bao#BAO_0000977 new mexico molecular libraries screening center http://www.bioassayontology.org/bao#BAO_0000709 research institute It is a specialized screening center of MLPCN. http://www.bioassayontology.org/bao#BAO_0002494 yeast two-hybrid assay http://www.bioassayontology.org/bao#BAO_0002492 two-hybrid assay Two-hybrid assay performed using yeast. http://www.bioassayontology.org/bao#BAO_0000419 endpoint correction http://www.bioassayontology.org/bao#BAO_0002754 assay data processing method This refers to the correction performed on the raw data values from an assay. B-score correction is a common method used for this purpose. http://www.bioassayontology.org/bao#BAO_0000516 1536 well plate http://www.bioassayontology.org/bao#BAO_0000508 microplate This microplate contains 1536 wells. It is highly miniaturized to accommodate more wells on one plate which reduces the plate handling time and allows working with very small volumes (few microliters) that reduces the cost of an assay. http://purl.obolibrary.org/obo/NCIT_C89775 Bleeding Time http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics The amount of time it take for a cessation of bleeding. It is a measurement of the ability of capillaries and platelets to interact to form a blood clot. http://purl.obolibrary.org/obo/NCIT_C90370 Central Nervous System Pharmacology http://www.bioassayontology.org/bao#BAO_0002533 safety pharmacology assay The branch of pharmacology that deals with the central nervous system. http://purl.obolibrary.org/obo/NCIT_C90449 Respiratory Pharmacology http://www.bioassayontology.org/bao#BAO_0002533 safety pharmacology assay The branch of pharmacology that deals with the respiratory system. http://purl.obolibrary.org/obo/DOID_0080355 hepatobiliary system cancer http://purl.obolibrary.org/obo/DOID_3119 gastrointestinal system cancer A gastrointestinal system cancer that is located_in the hepatobiliary system. http://purl.obolibrary.org/obo/DOID_0080373 epididymis disease http://purl.obolibrary.org/obo/DOID_48 male reproductive system disease A male reproductive system disease that is located_in the epididymis. http://purl.obolibrary.org/obo/DOID_0080601 germ cell benign neoplasm http://purl.obolibrary.org/obo/DOID_0060084 cell type benign neoplasm A benign neoplasm that derives_from germ cells. http://www.bioassayontology.org/bao#BAO_0000418 fungi http://www.bioassayontology.org/bao#BAO_0000509 eukaryote Fungi are either unicellular or multicellular and include yeasts, molds, mushrooms, etc. Several parasitic fungi exist, which infect animals and plants, e.g., Aspergillus flavus, Claviceps purpurea, Pneumocystis jirovecii, etc. http://www.bioassayontology.org/bao#BAO_0000662 protozoan http://www.bioassayontology.org/bao#BAO_0000509 eukaryote Protozoans are single celled organisms, some of which are parasitic, e.g., Plasmodium falciparum, Leishmania mexicana, Trypanosoma brucei, etc which cause malaria, leishmaniasis, and sleeping sickness, respectively. http://www.bioassayontology.org/bao#BAO_0080003 IC30 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint The effective concentration of an inhibitor, which produces 30% of the maximum possible response for that inhibitor. http://www.bioassayontology.org/bao#BAO_0000963 Macrophage inflammatory protein 3 alpha http://www.bioassayontology.org/bao#BAO_0000369 secreted MIP3a, CCL20 peptide http://www.bioassayontology.org/bao#BAO_0000582 gene http://www.bioassayontology.org/bao#BAO_0003111 biological macromolecule A genomic sequence, which is the unit of heredity of a living organism. It consists of regulatory regions and transcribed regions. http://www.bioassayontology.org/bao#BAO_0000869 broad institute http://www.bioassayontology.org/bao#BAO_0000709 research institute It is an MLPCN comprehensive screening center. http://www.bioassayontology.org/bao#BAO_0002245 multiple sequence alignment http://www.bioassayontology.org/bao#BAO_0002244 sequence alignment by type Multiple sequence alignment is an extension of pairwise alignment to incorporate more than two sequences at a time. http://www.bioassayontology.org/bao#BAO_0002766 T1/2(in vivo) http://www.bioassayontology.org/bao#BAO_0002115 T1/2 The time taken for the concentration of the drug in a particular tissue or blood plasma to decrease by half. http://www.bioassayontology.org/bao#BAO_0002881 AC40 absolute http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint The compound concentration at which the fitted curve passes activity threshold 40. http://www.bioassayontology.org/bao#BAO_0080001 IC20 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint The effective concentration of an inhibitor, which produces 20% of the maximum possible response for that inhibitor. http://www.bioassayontology.org/bao#BAO_0002234 AVID sequence alignment http://www.bioassayontology.org/bao#BAO_0002233 global sequence alignment Pairwise global alignment with whole genomes. http://www.bioassayontology.org/bao#BAO_0000807 variant construct assay http://www.bioassayontology.org/bao#BAO_0000803 counter screening assay This assay is performed with a different DNA construct than that was used in primary or confirmatory assays to modify a cell line. http://www.bioassayontology.org/bao#BAO_0000103 endpoint action correlation http://www.bioassayontology.org/bao#BAO_0003115 assay result component Endpoint action correlation describes weather a low or high endpoint value corresponds to low or high activity. Specifically if the endpoint value is positively or inversely correlated with the action that corresponds to the endpoint and which is specified as 'mode of action'. For example 'percent control' can be positively correlated with enzyme activity (remaining activity) and inversely correlated with the mode of action (function) inhibition depending on how the signal is normalized. http://www.bioassayontology.org/bao#BAO_0002424 western blot http://www.bioassayontology.org/bao#BAO_0002422 immunoblot The western blot (alternatively, protein immunoblot) is an analytical technique used to detect specific proteins in a given sample of tissue homogenate or extract. It uses gel electrophoresis to separate native or denatured proteins by the length of the polypeptide (denaturing conditions) or by the 3-D structure of the protein (native/ non-denaturing conditions). The proteins are then transferred to a membrane (typically nitrocellulose or PVDF), where they are probed (detected) using antibodies specific to the target protein. http://purl.obolibrary.org/obo/DOID_0080525 differentiated thyroid gland carcinoma http://purl.obolibrary.org/obo/DOID_0080524 thyroid gland adenocarcinoma A thyroid gland adenocarcinoma characterized by extensive evidence of follicular cell differentiation. http://purl.obolibrary.org/obo/DOID_0111962 combined immunodeficiency http://purl.obolibrary.org/obo/DOID_612 primary immunodeficiency disease A primary immunodeficiency disease that involves multiple components of the immune system. http://purl.obolibrary.org/obo/DOID_0080829 low-grade glioma http://purl.obolibrary.org/obo/DOID_3070 malignant glioma A malignant glioma that originate from two types of glial cells, astrocytes and oligodendrocytes. http://purl.obolibrary.org/obo/DOID_0080830 pediatric low-grade glioma http://purl.obolibrary.org/obo/DOID_0080829 low-grade glioma A low-grade glioma that occurs in children and encompasses tumors of astrocytic, oligodendroglial, and mixed glial-neuronal histology. http://www.bioassayontology.org/bao#BAO_0000875 Cyclic adenosine monophosphate http://www.bioassayontology.org/bao#BAO_0002010 nucleotide cAMP http://purl.obolibrary.org/obo/CHEBI_25512 neurotransmitter http://purl.obolibrary.org/obo/CHEBI_33280 molecular messenger neurotransmitters http://purl.obolibrary.org/obo/CHEBI_27311 volatile oil component http://purl.obolibrary.org/obo/CHEBI_25212 metabolite volatile oil components http://purl.obolibrary.org/obo/CHEBI_35444 antinematodal drug http://purl.obolibrary.org/obo/CHEBI_35443 anthelminthic drug antinematodals http://purl.obolibrary.org/obo/CHEBI_35469 antidepressant http://purl.obolibrary.org/obo/CHEBI_35471 psychotropic drug thymoleptics http://purl.obolibrary.org/obo/CHEBI_48318 fragrance http://purl.obolibrary.org/obo/CHEBI_33232 application scent http://purl.obolibrary.org/obo/CHEBI_49201 anti-ulcer drug http://purl.obolibrary.org/obo/CHEBI_23888 drug anti-ulcer drugs http://purl.obolibrary.org/obo/CHEBI_50218 EC 3.1.4.* (phosphoric diester hydrolase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76760 EC 3.1.* (ester hydrolase) inhibitor phosphoric diester hydrolase (EC 3.1.4.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_50268 GABA modulator http://purl.obolibrary.org/obo/CHEBI_51374 GABA agent GABA modulators http://purl.obolibrary.org/obo/CHEBI_50902 genotoxin http://purl.obolibrary.org/obo/CHEBI_52209 aetiopathogenetic role genotoxins http://purl.obolibrary.org/obo/CHEBI_50904 allergen http://purl.obolibrary.org/obo/CHEBI_52209 aetiopathogenetic role allergenic agent http://purl.obolibrary.org/obo/CHEBI_55324 gastrointestinal drug http://purl.obolibrary.org/obo/CHEBI_23888 drug gastrointestinal drugs http://purl.obolibrary.org/obo/CHEBI_59163 biomarker http://purl.obolibrary.org/obo/CHEBI_47867 indicator biological marker http://purl.obolibrary.org/obo/CHEBI_64915 antiplasmodial drug http://purl.obolibrary.org/obo/CHEBI_35442 antiparasitic agent antiplasmodium drugs http://purl.obolibrary.org/obo/CHEBI_67079 anti-inflammatory agent http://purl.obolibrary.org/obo/CHEBI_33232 application antiinflammatory agents http://purl.obolibrary.org/obo/CHEBI_67200 provitamin A http://purl.obolibrary.org/obo/CHEBI_50188 provitamin provitamin As http://purl.obolibrary.org/obo/CHEBI_72575 alarm pheromone http://purl.obolibrary.org/obo/CHEBI_26013 pheromone alarm substances http://purl.obolibrary.org/obo/CHEBI_76956 Aspergillus metabolite http://purl.obolibrary.org/obo/CHEBI_76946 fungal metabolite Aspergillus metabolites http://purl.obolibrary.org/obo/CHEBI_76967 human xenobiotic metabolite http://purl.obolibrary.org/obo/CHEBI_77746 human metabolite human xenobiotic metabolites http://purl.obolibrary.org/obo/CHEBI_83056 Daphnia magna metabolite http://purl.obolibrary.org/obo/CHEBI_83057 Daphnia metabolite Daphnia magna metabolites http://purl.obolibrary.org/obo/CHEBI_24527 herbicide http://purl.obolibrary.org/obo/CHEBI_25944 pesticide herbicides http://purl.obolibrary.org/obo/CHEBI_26089 photosystem-II inhibitor http://purl.obolibrary.org/obo/CHEBI_26087 photosynthetic electron-transport chain inhibitor photosystem II inhibitors http://purl.obolibrary.org/obo/CHEBI_33231 antitubercular agent http://purl.obolibrary.org/obo/CHEBI_64912 antimycobacterial drug tuberculostatic agent http://purl.obolibrary.org/obo/CHEBI_37699 protein kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_76668 EC 2.7.* (P-containing group transferase) inhibitor protein kinase inhibitors http://purl.obolibrary.org/obo/CHEBI_47868 photosensitizing agent http://purl.obolibrary.org/obo/CHEBI_23888 drug photosensitising agent http://purl.obolibrary.org/obo/CHEBI_51039 dopamine uptake inhibitor http://purl.obolibrary.org/obo/CHEBI_48560 dopaminergic agent dopamine uptake inhibitors http://purl.obolibrary.org/obo/CHEBI_64049 food acidity regulator http://purl.obolibrary.org/obo/CHEBI_64047 food additive pH control agents http://purl.obolibrary.org/obo/CHEBI_64345 MALDI matrix material http://purl.obolibrary.org/obo/CHEBI_33232 application 'matrix-assisted laser desorption/ionization' matrix material http://purl.obolibrary.org/obo/CHEBI_68494 apoptosis inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role apoptosis inhibitors http://purl.obolibrary.org/obo/CHEBI_74783 astringent http://purl.obolibrary.org/obo/CHEBI_23888 drug astringents http://purl.obolibrary.org/obo/CHEBI_77307 cardioprotective agent http://purl.obolibrary.org/obo/CHEBI_50267 protective agent cardioprotective agents http://purl.obolibrary.org/obo/CHEBI_131186 IP3 receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist D-myo-inositol 1,4,5-trisphosphate receptor antagonist http://purl.obolibrary.org/obo/CHEBI_131359 adenosine A2B receptor agonist http://purl.obolibrary.org/obo/CHEBI_73311 adenosine receptor agonist adenosine A2B receptor agonists http://purl.obolibrary.org/obo/CHEBI_131492 Wnt signalling activator http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role Wnt signalling activators http://purl.obolibrary.org/obo/CHEBI_131495 formyl peptide receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist formyl peptide receptor agonists http://purl.obolibrary.org/obo/CHEBI_131509 lysine-specific histone demethylase 1A inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role lysine-specific histone demethylase 1A inhibitors http://purl.obolibrary.org/obo/CHEBI_131561 hyaluronic acid synthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor hyaluronic acid synthesis inhibitors http://purl.obolibrary.org/obo/CHEBI_131611 teichoic acid biosynthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role teichoic acid biosynthesis inhibitors http://purl.obolibrary.org/obo/CHEBI_131699 EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor http://purl.obolibrary.org/obo/CHEBI_38234 DNA polymerase inhibitor DNA nucleotidyltransferase (DNA-directed) inhibitor http://purl.obolibrary.org/obo/CHEBI_131734 EC 2.7.11.20 (elongation factor 2 kinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76812 EC 2.7.11.* (protein-serine/threonine kinase) inhibitor EC 2.7.11.20 (elongation factor 2 kinase) inhibitors http://purl.obolibrary.org/obo/CHEBI_131770 EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76895 EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor cystic fibrosis transmembrane conductance regulator inhibitor http://purl.obolibrary.org/obo/CHEBI_131789 RUNX1 inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor runt-related transcription factor 1 inhibitors http://purl.obolibrary.org/obo/CHEBI_131790 melatonin receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist melatonin receptor antagonists http://purl.obolibrary.org/obo/CHEBI_131791 HIV-1 Tat inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor human immunodeficiency virus type 1 Tat antagonists http://purl.obolibrary.org/obo/CHEBI_131794 EC 2.7.11.17 (Ca(2+)/calmodulin-dependent protein kinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76812 EC 2.7.11.* (protein-serine/threonine kinase) inhibitor Ca(2+)/calmodulin-dependent protein kinase kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_131795 dopamine receptor D1 agonist http://purl.obolibrary.org/obo/CHEBI_51065 dopamine agonist dopamine receptor D1 agonists http://purl.obolibrary.org/obo/CHEBI_131809 SMO receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist smoothened receptor agonists http://purl.obolibrary.org/obo/CHEBI_131844 EC 1.14.11.1 (gamma-butyrobetaine dioxygenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76902 EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor EC 1.14.11.1 (gamma-butyrobetaine dioxygenase) inhibitors http://purl.obolibrary.org/obo/CHEBI_13193 hydrogen acceptor http://purl.obolibrary.org/obo/CHEBI_17654 electron acceptor R http://purl.obolibrary.org/obo/CHEBI_131961 EC 1.13.11.11 (tryptophan 2,3-dioxygenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76837 EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor EC 1.13.11.11 (tryptophan 2,3-dioxygenase) inhibitors http://purl.obolibrary.org/obo/CHEBI_132272 herbicide safener http://purl.obolibrary.org/obo/CHEBI_33286 agrochemical herbicide safeners http://purl.obolibrary.org/obo/CHEBI_132365 EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76902 EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) inhibitor http://purl.obolibrary.org/obo/CHEBI_132518 EC 3.2.1.23 (beta-galactosidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_52424 EC 3.2.1.* (glycosidase) inhibitor trilactase inhibitors http://purl.obolibrary.org/obo/CHEBI_132608 TRPM4 channel inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor Transient receptor potential cation channel subfamily M member 4 inhibitors http://purl.obolibrary.org/obo/CHEBI_132710 xenoantigen http://purl.obolibrary.org/obo/CHEBI_59132 antigen xenoantigens http://purl.obolibrary.org/obo/CHEBI_132771 EC 3.6.5.* (hydrolases acting on GTP; involved in cellular and subcellular movement) inhibitor http://purl.obolibrary.org/obo/CHEBI_73216 EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor EC 3.6.5.* (hydrolases acting on GTP; involved in cellular and subcellular movement) inhibitors http://purl.obolibrary.org/obo/CHEBI_132772 EC 3.6.5.5 (dynamin GTPase) inhibitor http://purl.obolibrary.org/obo/CHEBI_132771 EC 3.6.5.* (hydrolases acting on GTP; involved in cellular and subcellular movement) inhibitor dynamin GTPase inhibitors http://purl.obolibrary.org/obo/CHEBI_133811 EC 2.4.1.17 (glucuronosyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76789 EC 2.4.1.* (hexosyltransferase) inhibitor uridine 5'-diphosphoglucuronyltransferase inhibitors http://purl.obolibrary.org/obo/CHEBI_134182 platelet-activating factor receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist platelet-activating factor receptor antagonists http://purl.obolibrary.org/obo/CHEBI_17499 hydrogen donor http://purl.obolibrary.org/obo/CHEBI_15022 electron donor Reduced acceptor http://purl.obolibrary.org/obo/CHEBI_17654 electron acceptor http://purl.obolibrary.org/obo/CHEBI_15339 acceptor oxidized donor http://purl.obolibrary.org/obo/CHEBI_22180 EC 2.2.1.6 (acetolactate synthase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76876 EC 2.2.1.* (transketolase/transaldolase) inhibitor acetolactate pyruvate-lyase (carboxylating) inhibitors http://purl.obolibrary.org/obo/CHEBI_22583 antifeedant http://purl.obolibrary.org/obo/CHEBI_25944 pesticide antifeedants http://purl.obolibrary.org/obo/CHEBI_22917 phytogenic insecticide http://purl.obolibrary.org/obo/CHEBI_24852 insecticide phytogenic insecticides http://purl.obolibrary.org/obo/CHEBI_23357 cofactor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role cofactors http://purl.obolibrary.org/obo/CHEBI_24852 insecticide http://purl.obolibrary.org/obo/CHEBI_25944 pesticide insecticides http://purl.obolibrary.org/obo/CHEBI_25491 nematicide http://purl.obolibrary.org/obo/CHEBI_25944 pesticide nematocide http://purl.obolibrary.org/obo/CHEBI_26013 pheromone http://purl.obolibrary.org/obo/CHEBI_26645 semiochemical pheromones http://purl.obolibrary.org/obo/CHEBI_26155 plant growth regulator http://purl.obolibrary.org/obo/CHEBI_39317 growth regulator plant growth regulators http://purl.obolibrary.org/obo/CHEBI_26645 semiochemical http://purl.obolibrary.org/obo/CHEBI_33280 molecular messenger semiochemicals http://purl.obolibrary.org/obo/CHEBI_26841 synthetic auxin http://purl.obolibrary.org/obo/CHEBI_22676 auxin synthetic auxins http://purl.obolibrary.org/obo/CHEBI_27026 toxin http://purl.obolibrary.org/obo/CHEBI_25212 metabolite toxins http://purl.obolibrary.org/obo/CHEBI_27780 detergent http://purl.obolibrary.org/obo/CHEBI_33232 application detergent http://purl.obolibrary.org/obo/CHEBI_33893 reagent http://purl.obolibrary.org/obo/CHEBI_33232 application reagents http://purl.obolibrary.org/obo/CHEBI_35195 surfactant http://purl.obolibrary.org/obo/CHEBI_63046 emulsifier surfactants http://purl.obolibrary.org/obo/CHEBI_35219 plant growth retardant http://purl.obolibrary.org/obo/CHEBI_26155 plant growth regulator plant growth retardants http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor http://purl.obolibrary.org/obo/CHEBI_24432 biological role inhibitors http://purl.obolibrary.org/obo/CHEBI_35223 catalyst http://purl.obolibrary.org/obo/CHEBI_51086 chemical role catalyst http://purl.obolibrary.org/obo/CHEBI_35224 effector http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role enzyme modulator http://purl.obolibrary.org/obo/CHEBI_35225 buffer http://purl.obolibrary.org/obo/CHEBI_51086 chemical role buffer compounds http://purl.obolibrary.org/obo/CHEBI_35337 central nervous system stimulant http://purl.obolibrary.org/obo/CHEBI_35470 central nervous system drug central stimulant http://purl.obolibrary.org/obo/CHEBI_35493 antipyretic http://purl.obolibrary.org/obo/CHEBI_23888 drug anti-pyretic http://purl.obolibrary.org/obo/CHEBI_35497 androgen antagonist http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist antiandrogen http://purl.obolibrary.org/obo/CHEBI_35526 hypoglycemic agent http://purl.obolibrary.org/obo/CHEBI_23888 drug hypoglycemic drugs http://purl.obolibrary.org/obo/CHEBI_35530 beta-adrenergic antagonist http://purl.obolibrary.org/obo/CHEBI_48540 beta-adrenergic drug beta-blockers http://purl.obolibrary.org/obo/CHEBI_35617 flavouring agent http://purl.obolibrary.org/obo/CHEBI_64047 food additive flavouring agents http://purl.obolibrary.org/obo/CHEBI_35705 immunosuppressive agent http://purl.obolibrary.org/obo/CHEBI_50846 immunomodulator inmunosupresor http://purl.obolibrary.org/obo/CHEBI_35856 lipoxygenase inhibitor http://purl.obolibrary.org/obo/CHEBI_76837 EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor lipoxygenase inhibitors http://purl.obolibrary.org/obo/CHEBI_36335 trypanocidal drug http://purl.obolibrary.org/obo/CHEBI_35820 antiprotozoal drug trypanosomicidal agents http://purl.obolibrary.org/obo/CHEBI_37335 MRI contrast agent http://purl.obolibrary.org/obo/CHEBI_37334 diagnostic imaging agent magnetic resonance imaging contrast agent http://purl.obolibrary.org/obo/CHEBI_38161 chelator http://purl.obolibrary.org/obo/CHEBI_52214 ligand complexon http://purl.obolibrary.org/obo/CHEBI_38231 phytotoxin http://purl.obolibrary.org/obo/CHEBI_76924 plant metabolite phytotoxins http://purl.obolibrary.org/obo/CHEBI_38462 EC 3.1.1.7 (acetylcholinesterase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76773 EC 3.1.1.* (carboxylic ester hydrolase) inhibitor true cholinesterase inhibitors http://purl.obolibrary.org/obo/CHEBI_38623 EC 1.4.3.4 (monoamine oxidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76861 EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor monoamine:O2 oxidoreductase (deaminating) inhibitor http://purl.obolibrary.org/obo/CHEBI_38633 sodium channel blocker http://purl.obolibrary.org/obo/CHEBI_39000 sodium channel modulator sodium channel blockers http://purl.obolibrary.org/obo/CHEBI_38869 general anaesthetic http://purl.obolibrary.org/obo/CHEBI_38867 anaesthetic general anesthetics http://purl.obolibrary.org/obo/CHEBI_39116 pyrethroid ester insecticide http://purl.obolibrary.org/obo/CHEBI_26413 pyrethroid insecticide pyrethroid ester insecticides http://purl.obolibrary.org/obo/CHEBI_39208 antibiotic insecticide http://purl.obolibrary.org/obo/CHEBI_39215 antibiotic pesticide antibiotic insecticides http://purl.obolibrary.org/obo/CHEBI_48356 protic solvent http://purl.obolibrary.org/obo/CHEBI_48354 polar solvent protogenic solvent http://purl.obolibrary.org/obo/CHEBI_48578 radical scavenger http://purl.obolibrary.org/obo/CHEBI_22586 antioxidant free-radical scavenger http://purl.obolibrary.org/obo/CHEBI_48705 agonist http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role agonists http://purl.obolibrary.org/obo/CHEBI_50141 bronchoconstrictor agent http://purl.obolibrary.org/obo/CHEBI_23888 drug bronchoconstrictor drug http://purl.obolibrary.org/obo/CHEBI_50177 dermatologic drug http://purl.obolibrary.org/obo/CHEBI_23888 drug dermatological agent http://purl.obolibrary.org/obo/CHEBI_50266 prodrug http://purl.obolibrary.org/obo/CHEBI_23888 drug Prodrugs http://purl.obolibrary.org/obo/CHEBI_50427 platelet aggregation inhibitor http://purl.obolibrary.org/obo/CHEBI_50248 hematologic agent platelet aggregation inhibitors http://purl.obolibrary.org/obo/CHEBI_50503 laxative http://purl.obolibrary.org/obo/CHEBI_23888 drug purgatives http://purl.obolibrary.org/obo/CHEBI_50683 EC 1.5.1.3 (dihydrofolate reductase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76863 EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor tetrahydrofolate dehydrogenase inhibitors http://purl.obolibrary.org/obo/CHEBI_50733 nutraceutical http://purl.obolibrary.org/obo/CHEBI_23888 drug Nutritional supplement http://purl.obolibrary.org/obo/CHEBI_50751 anti-estrogen http://purl.obolibrary.org/obo/CHEBI_23888 drug antioestrogenic drug http://purl.obolibrary.org/obo/CHEBI_50857 anti-allergic agent http://purl.obolibrary.org/obo/CHEBI_23888 drug anti-allergic drugs http://purl.obolibrary.org/obo/CHEBI_50909 nephrotoxic agent http://purl.obolibrary.org/obo/CHEBI_52209 aetiopathogenetic role nephrotoxicant http://purl.obolibrary.org/obo/CHEBI_51065 dopamine agonist http://purl.obolibrary.org/obo/CHEBI_48560 dopaminergic agent Dopaminergic agonist http://purl.obolibrary.org/obo/CHEBI_51217 fluorochrome http://purl.obolibrary.org/obo/CHEBI_51121 fluorescent dye fluorochromes http://purl.obolibrary.org/obo/CHEBI_52217 pharmaceutical http://purl.obolibrary.org/obo/CHEBI_33232 application pharmaceuticals http://purl.obolibrary.org/obo/CHEBI_52290 mitogen http://purl.obolibrary.org/obo/CHEBI_24432 biological role mitogens http://purl.obolibrary.org/obo/CHEBI_52424 EC 3.2.1.* (glycosidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76761 EC 3.2.* (glycosylase) inhibitor glycoside hydrolase inhibitors http://purl.obolibrary.org/obo/CHEBI_53121 adenosine A2A receptor antagonist http://purl.obolibrary.org/obo/CHEBI_71232 adenosine receptor antagonist adenosine A2A receptor antagonists http://purl.obolibrary.org/obo/CHEBI_59132 antigen http://purl.obolibrary.org/obo/CHEBI_24432 biological role antigens http://purl.obolibrary.org/obo/CHEBI_59997 EC 1.14.18.1 (tyrosinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76845 EC 1.14.18.* (oxidoreductase acting on paired donors, miscellaneous compound as one donor, incorporating 1 atom of oxygen) inhibitor monophenol dihydroxyphenylalanine:oxygen oxidoreductase inhibitor http://purl.obolibrary.org/obo/CHEBI_60311 thyroid hormone http://purl.obolibrary.org/obo/CHEBI_24621 hormone thyroid hormones http://purl.obolibrary.org/obo/CHEBI_61016 angiotensin receptor antagonist http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist angiotensin receptor antagonists http://purl.obolibrary.org/obo/CHEBI_62434 EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_38637 tyrosine kinase inhibitor EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitors http://purl.obolibrary.org/obo/CHEBI_62488 signalling molecule http://purl.obolibrary.org/obo/CHEBI_33280 molecular messenger signalling molecules http://purl.obolibrary.org/obo/CHEBI_62872 EC 1.2.3.1 (aldehyde oxidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76853 EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor retinoic acid synthase inhibitors http://purl.obolibrary.org/obo/CHEBI_63957 adenosine A1 receptor antagonist http://purl.obolibrary.org/obo/CHEBI_71232 adenosine receptor antagonist adenosine A1 receptor antagonists http://purl.obolibrary.org/obo/CHEBI_64033 EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76807 EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor fatty acid amide hydrolase (EC 3.5.1.99) inhibitors http://purl.obolibrary.org/obo/CHEBI_64571 NMDA receptor agonist http://purl.obolibrary.org/obo/CHEBI_50103 excitatory amino acid agonist NMDAR agonists http://purl.obolibrary.org/obo/CHEBI_64909 poison http://purl.obolibrary.org/obo/CHEBI_24432 biological role toxic substances http://purl.obolibrary.org/obo/CHEBI_64947 anti-HIV-1 agent http://purl.obolibrary.org/obo/CHEBI_64946 anti-HIV agent anti-LAV agents http://purl.obolibrary.org/obo/CHEBI_65255 food preservative http://purl.obolibrary.org/obo/CHEBI_64047 food additive food preservatives http://purl.obolibrary.org/obo/CHEBI_65259 GABA antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist gamma-aminobutyric acid receptor antagonists http://purl.obolibrary.org/obo/CHEBI_66900 prostaglandin receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist prostaglandin receptor agonists http://purl.obolibrary.org/obo/CHEBI_67114 ryanodine receptor agonist http://purl.obolibrary.org/obo/CHEBI_38809 ryanodine receptor modulator ryanodine receptor activators http://purl.obolibrary.org/obo/CHEBI_67232 EC 3.2.1.10 (oligo-1,6-glucosidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_52424 EC 3.2.1.* (glycosidase) inhibitor sucrase-isomaltase inhibitors http://purl.obolibrary.org/obo/CHEBI_67239 EC 3.2.1.20 (alpha-glucosidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_52424 EC 3.2.1.* (glycosidase) inhibitor maltase-glucoamylase inhibitors http://purl.obolibrary.org/obo/CHEBI_70722 EC 6.4.1.2 (acetyl-CoA carboxylase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76824 EC 6.4.1.* (carboxylase) inhibitor acetyl-CoA:carbon-dioxide ligase (ADP-forming) inhibitor http://purl.obolibrary.org/obo/CHEBI_70727 topoisomerase inhibitor http://purl.obolibrary.org/obo/CHEBI_76830 EC 5.99.1.* (miscellaneous isomerase) inhibitor topoisomerase inhibitors http://purl.obolibrary.org/obo/CHEBI_70774 capsaicin receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist transient receptor potential cation channel subfamily V member 1 antagonists http://purl.obolibrary.org/obo/CHEBI_70782 PPARalpha agonist http://purl.obolibrary.org/obo/CHEBI_70781 PPAR modulator peroxisome proliferator-activated receptor-alpha agonists http://purl.obolibrary.org/obo/CHEBI_70868 antileishmanial agent http://purl.obolibrary.org/obo/CHEBI_35820 antiprotozoal drug antileishmanial drugs http://purl.obolibrary.org/obo/CHEBI_71692 insect repellent http://purl.obolibrary.org/obo/CHEBI_24852 insecticide insect repellents http://purl.obolibrary.org/obo/CHEBI_73192 EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76860 EC 1.3.3.* (oxidoreductase acting on donor CH-CH group, oxygen as acceptor) inhibitor protoporphyrinogen-IX:oxygen oxidoreductase inhibitor http://purl.obolibrary.org/obo/CHEBI_73216 EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor http://purl.obolibrary.org/obo/CHEBI_76759 EC 3.* (hydrolase) inhibitor EC 3.6.* (hydrolases acting on acid anhydrides) inhibitors http://purl.obolibrary.org/obo/CHEBI_73240 NF-kappaB inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor nuclear factor kappa-light-chain-enhancer of activated B cells inhibitor http://purl.obolibrary.org/obo/CHEBI_73311 adenosine receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist adenosine receptor agonist http://purl.obolibrary.org/obo/CHEBI_73335 ultraviolet filter http://purl.obolibrary.org/obo/CHEBI_52215 photochemical role ultraviolet filters http://purl.obolibrary.org/obo/CHEBI_74440 epidermal growth factor receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist epidermal growth factor receptor inhibitors http://purl.obolibrary.org/obo/CHEBI_74518 anti-obesity agent http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role anti-obestic agents http://purl.obolibrary.org/obo/CHEBI_75047 B-Raf inhibitor http://purl.obolibrary.org/obo/CHEBI_50925 EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor human mutant serine/threonine kinase inhibitors http://purl.obolibrary.org/obo/CHEBI_75768 mammalian metabolite http://purl.obolibrary.org/obo/CHEBI_75767 animal metabolite mammalian metabolites http://purl.obolibrary.org/obo/CHEBI_75769 B vitamin http://purl.obolibrary.org/obo/CHEBI_27314 water-soluble vitamin vitamin B http://purl.obolibrary.org/obo/CHEBI_76595 nephroprotective agent http://purl.obolibrary.org/obo/CHEBI_50267 protective agent nephroprotective agents http://purl.obolibrary.org/obo/CHEBI_76617 EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_38637 tyrosine kinase inhibitor non-specific protein-tyrosine kinase (EC 2.7.10.2) inhibitor http://purl.obolibrary.org/obo/CHEBI_76811 EC 3.1.4.12 (sphingomyelin phosphodiesterase) inhibitor http://purl.obolibrary.org/obo/CHEBI_50218 EC 3.1.4.* (phosphoric diester hydrolase) inhibitor sphingomyelin phosphodiesterase (EC 3.1.4.12) inhibitor http://purl.obolibrary.org/obo/CHEBI_76812 EC 2.7.11.* (protein-serine/threonine kinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76668 EC 2.7.* (P-containing group transferase) inhibitor protein-serine/threonine kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_76837 EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor http://purl.obolibrary.org/obo/CHEBI_76740 EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitors http://purl.obolibrary.org/obo/CHEBI_76895 EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor http://purl.obolibrary.org/obo/CHEBI_73216 EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitors http://purl.obolibrary.org/obo/CHEBI_76988 xenoestrogen http://purl.obolibrary.org/obo/CHEBI_138015 endocrine disruptor xenoestrogens http://purl.obolibrary.org/obo/CHEBI_77255 EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_59107 EC 3.4.24.* (metalloendopeptidase) inhibitor anthrax lethal factor endopeptidase (EC 3.4.24.83) inhibitors http://purl.obolibrary.org/obo/CHEBI_77745 EC 3.4.24.18 (meprin A) inhibitor http://purl.obolibrary.org/obo/CHEBI_59107 EC 3.4.24.* (metalloendopeptidase) inhibitor N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase inhibitors http://purl.obolibrary.org/obo/CHEBI_77747 EC 3.6.3.1 (phospholipid-translocating ATPase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76895 EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor ATP phosphohydrolase (phospholipid-flipping) inhibitor http://purl.obolibrary.org/obo/CHEBI_77748 EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76895 EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor xenobiotic-transporting ATPase (EC 3.6.3.44) inhibitor http://purl.obolibrary.org/obo/CHEBI_79050 EC 3.4.22.52 (calpain-1) inhibitor http://purl.obolibrary.org/obo/CHEBI_82824 calpain inhibitor mu-calpain inhibitors http://purl.obolibrary.org/obo/CHEBI_79085 potassium channel opener http://purl.obolibrary.org/obo/CHEBI_50510 potassium channel modulator potassium channel openers http://purl.obolibrary.org/obo/CHEBI_82665 EC 2.7.11.22 (cyclin-dependent kinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76812 EC 2.7.11.* (protein-serine/threonine kinase) inhibitor cyclin-dependent protein kinase activating kinase inhibitors http://purl.obolibrary.org/obo/CHEBI_82821 EC 3.4.22.53 (calpain-2) inhibitor http://purl.obolibrary.org/obo/CHEBI_82824 calpain inhibitor milli-calpain inhibitors http://purl.obolibrary.org/obo/CHEBI_83039 crustacean metabolite http://purl.obolibrary.org/obo/CHEBI_75767 animal metabolite crustacean metabolites http://purl.obolibrary.org/obo/CHEBI_83399 marine xenobiotic metabolite http://purl.obolibrary.org/obo/CHEBI_76206 xenobiotic metabolite marine xenobiotic metabolites http://purl.obolibrary.org/obo/CHEBI_83762 EC 3.2.1.28 (alpha,alpha-trehalase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76789 EC 2.4.1.* (hexosyltransferase) inhibitor alpha,alpha-trehalase inhibitors http://purl.obolibrary.org/obo/CHEBI_84087 human urinary metabolite http://purl.obolibrary.org/obo/CHEBI_77746 human metabolite human urinary metabolites http://purl.obolibrary.org/obo/CHEBI_85094 EC 2.7.11.11 (cAMP-dependent protein kinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76812 EC 2.7.11.* (protein-serine/threonine kinase) inhibitor cAMP-dependent protein kinase (EC 2.7.11.11) inhibitors http://purl.obolibrary.org/obo/CHEBI_86264 rat metabolite http://purl.obolibrary.org/obo/CHEBI_75768 mammalian metabolite rat metabolites http://purl.obolibrary.org/obo/CHEBI_86327 antifungal drug http://purl.obolibrary.org/obo/CHEBI_35718 antifungal agent pharmaceutical fungicides http://purl.obolibrary.org/obo/CHEBI_86328 antifungal agrochemical http://purl.obolibrary.org/obo/CHEBI_33286 agrochemical antifungal agrochemicals http://purl.obolibrary.org/obo/CHEBI_87183 STAT3 inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role signal transducer and activator of transcription 3 inhibitor http://purl.obolibrary.org/obo/CHEBI_90713 retinoic acid receptor alpha antagonist http://purl.obolibrary.org/obo/CHEBI_90714 retinoic acid receptor antagonist retinoic acid receptor alpha antagonists http://purl.obolibrary.org/obo/CHEBI_90714 retinoic acid receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist retinoic acid receptor antagonists http://purl.obolibrary.org/obo/CHEBI_91092 EC 2.7.11.26 (tau-protein kinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76812 EC 2.7.11.* (protein-serine/threonine kinase) inhibitor tau-tubulin inhibitors http://purl.obolibrary.org/obo/CHEBI_20569 EC 2.5.1.19 (3-phosphoshikimate 1-carboxyvinyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76663 EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor 3-enol-pyruvoylshikimate-5-phosphate synthase inhibitor http://purl.obolibrary.org/obo/CHEBI_22309 alicyclic antibiotics http://purl.obolibrary.org/obo/CHEBI_33281 antimicrobial agent alicyclic antibiotics http://purl.obolibrary.org/obo/CHEBI_22311 aliphatic antibiotics http://purl.obolibrary.org/obo/CHEBI_33281 antimicrobial agent aliphatic antibiotics http://purl.obolibrary.org/obo/CHEBI_22368 alpha-1-microglobulin-Ig alpha complex chromophores http://purl.obolibrary.org/obo/CHEBI_23240 chromophore alpha-1-microglobulin-Ig alpha complex chromophores http://purl.obolibrary.org/obo/CHEBI_22476 amino acid derivative antibiotics http://purl.obolibrary.org/obo/CHEBI_33281 antimicrobial agent amino acid derivative antibiotics http://purl.obolibrary.org/obo/CHEBI_22581 antiauxins http://purl.obolibrary.org/obo/CHEBI_26155 plant growth regulator antiauxins http://purl.obolibrary.org/obo/CHEBI_22986 calcium ionophore http://purl.obolibrary.org/obo/CHEBI_24869 ionophore calcium ionophores http://purl.obolibrary.org/obo/CHEBI_23092 chemosterilant http://purl.obolibrary.org/obo/CHEBI_25944 pesticide chemosterilants http://purl.obolibrary.org/obo/CHEBI_23100 chitin synthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_24851 insect growth regulator chitin synthesis inhibitors http://purl.obolibrary.org/obo/CHEBI_23529 cytochrome-b6f complex inhibitor http://purl.obolibrary.org/obo/CHEBI_26087 photosynthetic electron-transport chain inhibitor cytochrome b6f inhibitor http://purl.obolibrary.org/obo/CHEBI_23582 defoliant http://purl.obolibrary.org/obo/CHEBI_24527 herbicide defoliants http://purl.obolibrary.org/obo/CHEBI_23891 ecdysone antagonists http://purl.obolibrary.org/obo/CHEBI_24851 insect growth regulator ecdysone antagonists http://purl.obolibrary.org/obo/CHEBI_24028 iron(3+) chelator http://purl.obolibrary.org/obo/CHEBI_38157 iron chelator iron(III) chelator http://purl.obolibrary.org/obo/CHEBI_24319 EC 6.3.1.2 (glutamate--ammonia ligase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76823 EC 6.3.1.* (acid-ammonia/amine ligase) inhibitor L-glutamate:ammonia ligase (ADP-forming) inhibitors http://purl.obolibrary.org/obo/CHEBI_24430 group transfer coenzymes http://purl.obolibrary.org/obo/CHEBI_23354 coenzyme group transfer coenzymes http://purl.obolibrary.org/obo/CHEBI_24432 biological role http://www.bioassayontology.org/bao#BAO_0002929 role biological function http://purl.obolibrary.org/obo/CHEBI_24850 insect attractant http://purl.obolibrary.org/obo/CHEBI_25944 pesticide insect attractants http://purl.obolibrary.org/obo/CHEBI_24851 insect growth regulator http://purl.obolibrary.org/obo/CHEBI_39317 growth regulator insect growth regulators http://purl.obolibrary.org/obo/CHEBI_24853 intercalator http://purl.obolibrary.org/obo/CHEBI_25435 mutagen intercalators http://purl.obolibrary.org/obo/CHEBI_24869 ionophore http://purl.obolibrary.org/obo/CHEBI_38632 membrane transport modulator ionophores http://purl.obolibrary.org/obo/CHEBI_24874 iron ionophore http://purl.obolibrary.org/obo/CHEBI_24869 ionophore iron ionophores http://purl.obolibrary.org/obo/CHEBI_24941 juvenile hormone antagonists http://purl.obolibrary.org/obo/CHEBI_24851 insect growth regulator juvenile hormone antagonists http://purl.obolibrary.org/obo/CHEBI_24942 juvenile hormone mimic http://purl.obolibrary.org/obo/CHEBI_24851 insect growth regulator juvenile hormone mimics http://purl.obolibrary.org/obo/CHEBI_25540 neonicotinoid insectide http://purl.obolibrary.org/obo/CHEBI_50910 neurotoxin nicotinoid insectides http://purl.obolibrary.org/obo/CHEBI_25573 nodulation factor http://purl.obolibrary.org/obo/CHEBI_24432 biological role nodulation factors http://purl.obolibrary.org/obo/CHEBI_25943 pesticide synergist http://purl.obolibrary.org/obo/CHEBI_25944 pesticide pesticide synergists http://purl.obolibrary.org/obo/CHEBI_25944 pesticide http://purl.obolibrary.org/obo/CHEBI_33232 application pesticides http://purl.obolibrary.org/obo/CHEBI_26083 phosphorus containing antibiotics http://purl.obolibrary.org/obo/CHEBI_22311 aliphatic antibiotics phosphorus containing antibiotics http://purl.obolibrary.org/obo/CHEBI_26088 photosystem-I inhibitor http://purl.obolibrary.org/obo/CHEBI_26087 photosynthetic electron-transport chain inhibitor photosystem I inhibitors http://purl.obolibrary.org/obo/CHEBI_26157 plant growth stimulator http://purl.obolibrary.org/obo/CHEBI_26155 plant growth regulator plant growth stimulators http://purl.obolibrary.org/obo/CHEBI_26220 precocenes http://purl.obolibrary.org/obo/CHEBI_24941 juvenile hormone antagonists 7-alkoxy-2,2-dimethylchromenes http://purl.obolibrary.org/obo/CHEBI_26413 pyrethroid insecticide http://purl.obolibrary.org/obo/CHEBI_39000 sodium channel modulator pyrethroid insecticides http://purl.obolibrary.org/obo/CHEBI_26671 sideramine http://purl.obolibrary.org/obo/CHEBI_26672 siderophore sideramines http://purl.obolibrary.org/obo/CHEBI_33280 molecular messenger http://purl.obolibrary.org/obo/CHEBI_24432 biological role chemical messenger http://purl.obolibrary.org/obo/CHEBI_33904 molluscicide http://purl.obolibrary.org/obo/CHEBI_25944 pesticide molluscicides http://purl.obolibrary.org/obo/CHEBI_33937 macronutrient http://purl.obolibrary.org/obo/CHEBI_33284 nutrient macronutrients http://purl.obolibrary.org/obo/CHEBI_35204 tracer http://purl.obolibrary.org/obo/CHEBI_33232 application tracer http://purl.obolibrary.org/obo/CHEBI_35499 hallucinogen http://purl.obolibrary.org/obo/CHEBI_35471 psychotropic drug psychedelics http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role neurotransmitter agents http://purl.obolibrary.org/obo/CHEBI_37670 protease inhibitor http://purl.obolibrary.org/obo/CHEBI_60258 EC 3.4.* (hydrolases acting on peptide bond) inhibitor protease inhibitors http://purl.obolibrary.org/obo/CHEBI_37930 phenothiazine antipsychotic drug http://purl.obolibrary.org/obo/CHEBI_65190 first generation antipsychotic phenothiazine neuroleptics http://purl.obolibrary.org/obo/CHEBI_38155 phytosiderophore http://purl.obolibrary.org/obo/CHEBI_24874 iron ionophore phytosiderophores http://purl.obolibrary.org/obo/CHEBI_38461 carbamate insecticide http://purl.obolibrary.org/obo/CHEBI_38462 EC 3.1.1.7 (acetylcholinesterase) inhibitor carbamate insecticides http://purl.obolibrary.org/obo/CHEBI_38496 electron-transport chain inhibitor http://purl.obolibrary.org/obo/CHEBI_76932 pathway inhibitor electron transport chain inhibitors http://purl.obolibrary.org/obo/CHEBI_38497 respiratory-chain inhibitor http://purl.obolibrary.org/obo/CHEBI_38496 electron-transport chain inhibitor respiratory-chain inhibitors http://purl.obolibrary.org/obo/CHEBI_38632 membrane transport modulator http://purl.obolibrary.org/obo/CHEBI_52208 biophysical role membrane transport modulators http://purl.obolibrary.org/obo/CHEBI_39000 sodium channel modulator http://purl.obolibrary.org/obo/CHEBI_38632 membrane transport modulator sodium channel modulators http://purl.obolibrary.org/obo/CHEBI_39141 Bronsted acid http://purl.obolibrary.org/obo/CHEBI_37527 acid hydron donor http://purl.obolibrary.org/obo/CHEBI_39317 growth regulator http://purl.obolibrary.org/obo/CHEBI_24432 biological role growth regulators http://purl.obolibrary.org/obo/CHEBI_49200 EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76895 EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor ATP phosphohydrolase (H(+)/K(+)-exchanging) inhibitor http://purl.obolibrary.org/obo/CHEBI_50627 EC 3.2.1.1 (alpha-amylase) inhibitor http://purl.obolibrary.org/obo/CHEBI_52424 EC 3.2.1.* (glycosidase) inhibitor glycogenase inhibitors http://purl.obolibrary.org/obo/CHEBI_50643 EC 2.5.1.1 (dimethylallyltranstransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76663 EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor dimethylallyltranstransferase (EC 2.5.1.1) inhibitor http://purl.obolibrary.org/obo/CHEBI_50949 serotonin uptake inhibitor http://purl.obolibrary.org/obo/CHEBI_48278 serotonergic drug serotonin reuptake inhibitor http://purl.obolibrary.org/obo/CHEBI_51087 protecting group http://purl.obolibrary.org/obo/CHEBI_33232 application protective group http://purl.obolibrary.org/obo/CHEBI_52215 photochemical role http://purl.obolibrary.org/obo/CHEBI_51086 chemical role photochemical roles http://purl.obolibrary.org/obo/CHEBI_59672 EC 2.4.1.16 (chitin synthase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76789 EC 2.4.1.* (hexosyltransferase) inhibitor chitin-UDP N-acetylglucosaminyltransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_59739 electrophilic reagent http://purl.obolibrary.org/obo/CHEBI_39143 Lewis acid electrophilic reagents http://purl.obolibrary.org/obo/CHEBI_60688 EC 4.2.1.20 (tryptophan synthase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76907 EC 4.2.1.* (hydro-lyases) inhibitor L-serine hydro-lyase (adding indoleglycerol-phosphate) inhibitor http://purl.obolibrary.org/obo/CHEBI_60788 affinity label http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor affinity labels http://purl.obolibrary.org/obo/CHEBI_61015 nephrotoxin http://purl.obolibrary.org/obo/CHEBI_64909 poison nephrotoxins http://purl.obolibrary.org/obo/CHEBI_64152 cysteine protease inhibitor http://purl.obolibrary.org/obo/CHEBI_76796 EC 3.4.22.* (cysteine endopeptidase) inhibitor cysteine proteinase inhibitors http://purl.obolibrary.org/obo/CHEBI_64912 antimycobacterial drug http://purl.obolibrary.org/obo/CHEBI_36047 antibacterial drug antimycobacterium http://purl.obolibrary.org/obo/CHEBI_64953 anti-HSV-1 agent http://purl.obolibrary.org/obo/CHEBI_64952 anti-HSV agent anti-human herpes virus-I agents http://purl.obolibrary.org/obo/CHEBI_67105 insect sterilant http://purl.obolibrary.org/obo/CHEBI_23092 chemosterilant insect sterilants http://purl.obolibrary.org/obo/CHEBI_71178 EC 2.1.1.4 (acetylserotonin O-methyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76871 EC 2.1.1.* (methyltransferases) inhibitor acetylserotonin O-methyltransferase (EC 2.1.1.4) inhibitors http://purl.obolibrary.org/obo/CHEBI_73191 abscisic acid receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist abscisic acid receptor agonists http://purl.obolibrary.org/obo/CHEBI_73214 EC 3.6.3.14 (H(+)-transporting two-sector ATPase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76895 EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor ATP phosphohydrolase (H(+)-transporting) inhibitors http://purl.obolibrary.org/obo/CHEBI_73966 nitric oxide synthase activator http://purl.obolibrary.org/obo/CHEBI_35224 effector nitric oxide synthase activators http://purl.obolibrary.org/obo/CHEBI_76787 EC 3.4.11.* (aminopeptidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_60258 EC 3.4.* (hydrolases acting on peptide bond) inhibitor aminopeptidase (EC 3.4.11.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_76797 EC 2.5.1.18 (glutathione transferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76663 EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor glutathione transferase inhibitors http://purl.obolibrary.org/obo/CHEBI_76823 EC 6.3.1.* (acid-ammonia/amine ligase) inhibitor http://purl.obolibrary.org/obo/CHEBI_75600 EC 6.3.* (C-N bond-forming ligase) inhibitor acid-ammonia (or amine) ligase inhibitors http://purl.obolibrary.org/obo/CHEBI_76876 EC 2.2.1.* (transketolase/transaldolase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76660 EC 2.2.* (aldehyde or ketone transferase) inhibitor EC 2.2.1.* (transketolases and transaldolases) inhibitor http://purl.obolibrary.org/obo/CHEBI_76907 EC 4.2.1.* (hydro-lyases) inhibitor http://purl.obolibrary.org/obo/CHEBI_76712 EC 4.2.* (C-O lyase) inhibitor hydro-lyase (EC 4.2.1.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_78592 vesicant http://purl.obolibrary.org/obo/CHEBI_52208 biophysical role vesicants http://purl.obolibrary.org/obo/CHEBI_82632 phytochrome chromophore http://purl.obolibrary.org/obo/CHEBI_23240 chromophore phytochrome chromophores http://purl.obolibrary.org/obo/CHEBI_88227 potassium ionophore http://purl.obolibrary.org/obo/CHEBI_24869 ionophore potassium ionophores http://purl.obolibrary.org/obo/CHEBI_88230 autophagy inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role autophagy inhibitors http://purl.obolibrary.org/obo/CHEBI_91141 EC 1.1.5.3 (glycerol-3-phosphate dehydrogenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_91142 EC 1.1.5.* (oxidoreductase acting on donor CH-OH group, quinone or similar compound as acceptor) inhibitor EC 1.1.5.3 (glycerol-3-phosphate dehydrogenase) inhibitors http://purl.obolibrary.org/obo/CHEBI_37153 EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76775 EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor serine/threonine specific protein phosphatase inhibitors http://purl.obolibrary.org/obo/CHEBI_37845 growth hormone http://purl.obolibrary.org/obo/CHEBI_24621 hormone growth hormones http://purl.obolibrary.org/obo/CHEBI_37961 H2-receptor antagonist http://purl.obolibrary.org/obo/CHEBI_37956 histamine antagonist histamine H2 receptor antagonists http://purl.obolibrary.org/obo/CHEBI_38162 iron(2+) chelator http://purl.obolibrary.org/obo/CHEBI_38157 iron chelator iron(II) chelator http://purl.obolibrary.org/obo/CHEBI_38456 ecdysone agonist http://purl.obolibrary.org/obo/CHEBI_24851 insect growth regulator ecdysone mimetic http://purl.obolibrary.org/obo/CHEBI_38502 cytochrome-bc1 complex inhibitor http://purl.obolibrary.org/obo/CHEBI_38497 respiratory-chain inhibitor cytochrome-bc1 inhibitor http://purl.obolibrary.org/obo/CHEBI_38503 EC 1.6.5.3 [NADH:ubiquinone reductase (H(+)-translocating)] inhibitor http://purl.obolibrary.org/obo/CHEBI_76866 EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor dihydronicotinamide adenine dinucleotide-coenzyme Q reductase inhibitor http://purl.obolibrary.org/obo/CHEBI_38828 nonionic surfactant http://purl.obolibrary.org/obo/CHEBI_35195 surfactant nonionic surfactants http://purl.obolibrary.org/obo/CHEBI_38849 blood substitute http://purl.obolibrary.org/obo/CHEBI_52217 pharmaceutical oxygen carrier http://purl.obolibrary.org/obo/CHEBI_39011 Good's buffer substance http://purl.obolibrary.org/obo/CHEBI_35225 buffer Good's buffers http://purl.obolibrary.org/obo/CHEBI_39142 Bronsted base http://purl.obolibrary.org/obo/CHEBI_22695 base hydron acceptor http://purl.obolibrary.org/obo/CHEBI_39144 Lewis base http://purl.obolibrary.org/obo/CHEBI_22695 base donneur d'une paire d'electrons http://purl.obolibrary.org/obo/CHEBI_39215 antibiotic pesticide http://purl.obolibrary.org/obo/CHEBI_33281 antimicrobial agent antibiotic pesticides http://purl.obolibrary.org/obo/CHEBI_39216 antibiotic acaricide http://purl.obolibrary.org/obo/CHEBI_22153 acaricide antibiotic acaricides http://purl.obolibrary.org/obo/CHEBI_39217 antibiotic nematicide http://purl.obolibrary.org/obo/CHEBI_39215 antibiotic pesticide antibiotic nematicides http://purl.obolibrary.org/obo/CHEBI_39277 fumigant insecticide http://purl.obolibrary.org/obo/CHEBI_39276 fumigant fumigant insecticides http://purl.obolibrary.org/obo/CHEBI_39301 sulfite ester acaricide http://purl.obolibrary.org/obo/CHEBI_22153 acaricide sulfite ester acaricides http://purl.obolibrary.org/obo/CHEBI_39316 mite growth regulator http://purl.obolibrary.org/obo/CHEBI_22153 acaricide mite growth regulators http://purl.obolibrary.org/obo/CHEBI_39318 tetrazine acaricide http://purl.obolibrary.org/obo/CHEBI_22153 acaricide tetrazine acaricides http://purl.obolibrary.org/obo/CHEBI_39351 pyrethroid ether insecticide http://purl.obolibrary.org/obo/CHEBI_26413 pyrethroid insecticide pyrethroid ether insecticides http://purl.obolibrary.org/obo/CHEBI_39415 dinitrophenol insecticide http://purl.obolibrary.org/obo/CHEBI_24852 insecticide dinitrophenol insecticides http://purl.obolibrary.org/obo/CHEBI_49205 CETP inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role cholesteryl ester transfer protein inhibitor http://purl.obolibrary.org/obo/CHEBI_59897 EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor http://purl.obolibrary.org/obo/CHEBI_22587 antiviral agent deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) inhibitor http://purl.obolibrary.org/obo/CHEBI_60258 EC 3.4.* (hydrolases acting on peptide bond) inhibitor http://purl.obolibrary.org/obo/CHEBI_76759 EC 3.* (hydrolase) inhibitor inhibitors of hydrolases acting on peptide bond (EC 3.4.*) http://purl.obolibrary.org/obo/CHEBI_63114 sphingosine-1-phosphate receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist sphingosine-1-phosphate receptor agonists http://purl.obolibrary.org/obo/CHEBI_63173 T-cell proliferation inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor T-cell proliferation inhibitors http://purl.obolibrary.org/obo/CHEBI_63962 Hsp90 inhibitor http://purl.obolibrary.org/obo/CHEBI_76939 EC 3.6.4.10 (non-chaperonin molecular chaperone ATPase) inhibitor heat shock protein 90 inhibitors http://purl.obolibrary.org/obo/CHEBI_68563 P2Y12 receptor antagonist http://purl.obolibrary.org/obo/CHEBI_91079 purinergic receptor P2 antagonist purinergic receptor subtype P2Y12 antagonists http://purl.obolibrary.org/obo/CHEBI_76668 EC 2.7.* (P-containing group transferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_71300 EC 2.* (transferase) inhibitor EC 2.7.* (P-containing group transferase) inhibitors http://purl.obolibrary.org/obo/CHEBI_76773 EC 3.1.1.* (carboxylic ester hydrolase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76760 EC 3.1.* (ester hydrolase) inhibitor carboxylic ester hydrolase (EC 3.1.1.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_76815 EC 2.7.7.* (nucleotidyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76668 EC 2.7.* (P-containing group transferase) inhibitor nucleotidyltransferase inhibitors http://purl.obolibrary.org/obo/CHEBI_76861 EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76730 EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor (EC 1.4.3.*) inhibitor http://purl.obolibrary.org/obo/CHEBI_76866 EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76733 EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor (EC 1.6.5.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_76870 EC 1.9.3.* (oxidoreductase acting on donor heme group, oxygen as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76736 EC 1.9.* (oxidoreductase acting on donor heme group) inhibitor oxidoreductase acting on donor heme group, oxygen as acceptor (EC 1.9.3.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_76926 EC 3.4.13.19 (membrane dipeptidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_59499 EC 3.4.13.* (dipeptidase) inhibitor renal dipeptidase inhibitors http://purl.obolibrary.org/obo/CHEBI_76932 pathway inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor pathway inhibitors http://purl.obolibrary.org/obo/CHEBI_77402 EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76869 EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitor trypanothione-disulfide reductase (EC 1.8.1.12) inhibitors http://purl.obolibrary.org/obo/CHEBI_78361 lichen metabolite http://purl.obolibrary.org/obo/CHEBI_25212 metabolite lichen metabolites http://purl.obolibrary.org/obo/CHEBI_86430 EC 1.14.13.78 (ent-kaurene oxidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76741 EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor ent-kaurene oxidase (EC 1.14.13.78) inhibitors http://purl.obolibrary.org/obo/CHEBI_48668 gamma-secretase modulator http://purl.obolibrary.org/obo/CHEBI_35224 effector gamma-secretase modulators http://purl.obolibrary.org/obo/CHEBI_49324 female contraceptive drug http://purl.obolibrary.org/obo/CHEBI_49323 contraceptive drug female contraceptive drugs http://purl.obolibrary.org/obo/CHEBI_49325 oral contraceptive http://purl.obolibrary.org/obo/CHEBI_49324 female contraceptive drug oral contraceptives http://purl.obolibrary.org/obo/CHEBI_50112 sex hormone http://purl.obolibrary.org/obo/CHEBI_24621 hormone sex hormones http://purl.obolibrary.org/obo/CHEBI_50242 enzyme reactivator http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role enzyme reactivators http://purl.obolibrary.org/obo/CHEBI_50382 EC 2.4.1.80 (ceramide glucosyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76789 EC 2.4.1.* (hexosyltransferase) inhibitor UDP-glucose:N-acylsphingosine D-glucosyltransferase inhibitors http://purl.obolibrary.org/obo/CHEBI_50408 visual indicator http://purl.obolibrary.org/obo/CHEBI_47867 indicator visual indicator http://purl.obolibrary.org/obo/CHEBI_50409 adsorption indicator http://purl.obolibrary.org/obo/CHEBI_50408 visual indicator indicateur par adsorption http://purl.obolibrary.org/obo/CHEBI_50410 colour indicator http://purl.obolibrary.org/obo/CHEBI_50408 visual indicator indicateurs colores http://purl.obolibrary.org/obo/CHEBI_50411 one-colour indicator http://purl.obolibrary.org/obo/CHEBI_50410 colour indicator one-colour indicator http://purl.obolibrary.org/obo/CHEBI_50433 platelet glycoprotein-IIb/IIIa receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist glycoprotein-IIb/IIIa receptor antagonists http://purl.obolibrary.org/obo/CHEBI_50685 antitrichomonal drug http://purl.obolibrary.org/obo/CHEBI_35820 antiprotozoal drug antitrichomonal agent http://purl.obolibrary.org/obo/CHEBI_50689 reproductive control drug http://purl.obolibrary.org/obo/CHEBI_23888 drug reproductive control drugs http://purl.obolibrary.org/obo/CHEBI_50779 appetite enhancer http://purl.obolibrary.org/obo/CHEBI_50780 appetite regulator orexigenic http://purl.obolibrary.org/obo/CHEBI_50780 appetite regulator http://purl.obolibrary.org/obo/CHEBI_23888 drug appetite regulators http://purl.obolibrary.org/obo/CHEBI_50827 antiparathyroid drug http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist antiparathyroid drugs http://purl.obolibrary.org/obo/CHEBI_50914 EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76881 EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor phosphatidylinositol 3-kinase (EC 2.7.1.137) inhibitors http://purl.obolibrary.org/obo/CHEBI_50916 lipid kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_76668 EC 2.7.* (P-containing group transferase) inhibitor lipid kinase inhibitors http://purl.obolibrary.org/obo/CHEBI_51061 hormone receptor modulator http://purl.obolibrary.org/obo/CHEBI_23888 drug hormone receptor modulators http://purl.obolibrary.org/obo/CHEBI_52209 aetiopathogenetic role http://purl.obolibrary.org/obo/CHEBI_24432 biological role etiopathogenetic role http://purl.obolibrary.org/obo/CHEBI_55351 substance P receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist substance P receptor antagonists http://purl.obolibrary.org/obo/CHEBI_60599 mu-opioid agent http://purl.obolibrary.org/obo/CHEBI_60598 opioid agent mu-opioid agents http://purl.obolibrary.org/obo/CHEBI_60605 opioid receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist opioid receptor antagonists http://purl.obolibrary.org/obo/CHEBI_70728 actin polymerisation inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor actin polymerization inhibitors http://purl.obolibrary.org/obo/CHEBI_70781 PPAR modulator http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role peroxisome proliferator-activated receptor modulators http://purl.obolibrary.org/obo/CHEBI_73361 methionine aminopeptidase 2 inhibitor http://purl.obolibrary.org/obo/CHEBI_73360 EC 3.4.11.18 (methionyl aminopeptidase) inhibitor methionine aminopeptidase-2 inhibitors http://purl.obolibrary.org/obo/CHEBI_73913 antifolate http://purl.obolibrary.org/obo/CHEBI_35221 antimetabolite folic acid antagonists http://purl.obolibrary.org/obo/CHEBI_75190 EC 5.4.3.2 (lysine 2,3-aminomutase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76829 EC 5.4.3.* (intramolecular transferase transferring amino groups) inhibitor lysine 2,3-aminomutase inhibitors http://purl.obolibrary.org/obo/CHEBI_76760 EC 3.1.* (ester hydrolase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76759 EC 3.* (hydrolase) inhibitor ester hydrolase inhibitors http://purl.obolibrary.org/obo/CHEBI_76809 EC 3.5.4.* (non-peptide cyclic amidine C-N hydrolase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76764 EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor non-peptide cyclic amidine C-N hydrolase inhibitors http://purl.obolibrary.org/obo/CHEBI_76838 EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76741 EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor oxidoreductase acting on paired donors, with incorporation of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor (EC 1.14.14.*) inhibitor http://purl.obolibrary.org/obo/CHEBI_76857 EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76729 EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor oxidoreductase acting on CH-CH group of donor with NAD(+) or NADP(+) as acceptor (EC 1.3.1.*) inhibitor http://purl.obolibrary.org/obo/CHEBI_76863 EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76731 EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor EC 1.5.1.* (oxidoreductase acting on donor CH-NH group, NAD(+) or NADP(+) as acceptor) inhibitors http://purl.obolibrary.org/obo/CHEBI_76867 EC 1.6.3.* (oxidoreductase acting on NADH or NADPH with oxygen as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76733 EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor oxidoreductase acting on NADH or NADPH with oxygen as acceptor (EC 1.6.3.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_76881 EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76668 EC 2.7.* (P-containing group transferase) inhibitor EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitors http://purl.obolibrary.org/obo/CHEBI_76898 EC 1.14.14.1 (unspecific monooxygenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76838 EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidising) inhibitors http://purl.obolibrary.org/obo/CHEBI_83317 sterol biosynthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role sterol biosynthesis inhibitors http://purl.obolibrary.org/obo/CHEBI_83319 EC 1.3.1.70 (Delta(14)-sterol reductase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76857 EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor Delta(14)-sterol reductase (EC 1.3.1.70) inhibitors http://purl.obolibrary.org/obo/CHEBI_90710 receptor modulator http://purl.obolibrary.org/obo/CHEBI_23888 drug receptor modulators http://purl.obolibrary.org/obo/CHEBI_90757 antidote to benzodiazepine poisoning http://purl.obolibrary.org/obo/CHEBI_50247 antidote antidote to benzodiazepine overdose http://purl.obolibrary.org/obo/CHEBI_60280 EC 3.5.1.2 (glutaminase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76807 EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor glutamine aminohydrolase inhibitors http://purl.obolibrary.org/obo/CHEBI_60598 opioid agent http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent opioid agents http://purl.obolibrary.org/obo/CHEBI_60649 glucagon receptor antagonist http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist glucagon receptor antagonists http://purl.obolibrary.org/obo/CHEBI_60798 excitatory amino acid antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist excitatory amino acid receptor antagonists http://purl.obolibrary.org/obo/CHEBI_61026 bile therapy drug http://purl.obolibrary.org/obo/CHEBI_23888 drug bile therapy drugs http://purl.obolibrary.org/obo/CHEBI_76730 EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor inhibitor of oxidoreductase acting on CH-NH2 group of donors http://purl.obolibrary.org/obo/CHEBI_77161 Toll-like receptor 2 agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist Toll-like receptor-2 agonists http://purl.obolibrary.org/obo/CHEBI_78058 food antifoaming agent http://purl.obolibrary.org/obo/CHEBI_64047 food additive food defoamers http://purl.obolibrary.org/obo/CHEBI_62530 EC 2.3.1.24 (sphingosine N-acyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76878 EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor EC 2.3.1.24 (sphingosine N-acyltransferase) inhibitors http://purl.obolibrary.org/obo/CHEBI_62887 tankyrase inhibitor http://purl.obolibrary.org/obo/CHEBI_76662 EC 2.4.* (glycosyltransferase) inhibitor tankyrase inhibitors http://purl.obolibrary.org/obo/CHEBI_62914 axin stabilizer http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role axin stabilizers http://purl.obolibrary.org/obo/CHEBI_62915 sialyltransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_76882 EC 2.4.99.* (glycosyltransferases transferring other glycosyl groups) inhibitor sialyltransferase inhibitors http://purl.obolibrary.org/obo/CHEBI_63064 crystallisation adjutant http://purl.obolibrary.org/obo/CHEBI_51086 chemical role crystallization adjutants http://purl.obolibrary.org/obo/CHEBI_63175 peptidomimetic http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role peptidomimetics http://purl.obolibrary.org/obo/CHEBI_63457 fibroblast growth factor receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist fibroblast growth factor receptor inhibitors http://purl.obolibrary.org/obo/CHEBI_63673 chemokine receptor 5 antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist chemokine receptor 5 antagonists http://purl.obolibrary.org/obo/CHEBI_63674 EC 2.6.1.19 (4-aminobutyrate--2-oxoglutarate transaminase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76879 EC 2.6.1.* (transaminase) inhibitor GABA--alpha-ketoglutarate aminotransferase inhibitors http://purl.obolibrary.org/obo/CHEBI_63720 EC 2.1.1.45 (thymidylate synthase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76871 EC 2.1.1.* (methyltransferases) inhibitor methylenetetrahydrofolate:dUMP C-methyltransferase inhibitors http://purl.obolibrary.org/obo/CHEBI_63721 EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76874 EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitor 10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase inhibitors http://purl.obolibrary.org/obo/CHEBI_63908 film-forming compound http://purl.obolibrary.org/obo/CHEBI_51086 chemical role film-forming compounds http://purl.obolibrary.org/obo/CHEBI_63936 alpha1B-adrenoceptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist alpha1B-adrenoceptor antagonists http://purl.obolibrary.org/obo/CHEBI_63951 estrogen receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist estrogen receptor agonists http://purl.obolibrary.org/obo/CHEBI_64088 incretin mimetic http://purl.obolibrary.org/obo/CHEBI_24432 biological role incretin mimetics http://purl.obolibrary.org/obo/CHEBI_64105 protein kinase G agonist http://purl.obolibrary.org/obo/CHEBI_64106 protein kinase agonist protein kinase G agonists http://purl.obolibrary.org/obo/CHEBI_64106 protein kinase agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist protein kinase agonists http://purl.obolibrary.org/obo/CHEBI_68542 EC 1.3.98.1 [dihydroorotate oxidase (fumarate)] inhibitor http://purl.obolibrary.org/obo/CHEBI_76858 EC 1.3.98.* (oxidoreductase acting on donor CH-CH group, with other, known, acceptors) inhibitor dihydroorotate oxidase (fumarate) (EC 1.3.98.1) inhibitors http://purl.obolibrary.org/obo/CHEBI_68543 pyrimidine synthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_76932 pathway inhibitor pyrimidine synthesis inhibitors http://purl.obolibrary.org/obo/CHEBI_71196 glucagon-like peptide-1 receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist glucagon-like peptide-1 receptor agonists http://purl.obolibrary.org/obo/CHEBI_73416 CB1 receptor antagonist http://purl.obolibrary.org/obo/CHEBI_73413 cannabinoid receptor antagonist type 1 cannabinoid receptor antagonists http://purl.obolibrary.org/obo/CHEBI_76662 EC 2.4.* (glycosyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_71300 EC 2.* (transferase) inhibitor glycosyltransferase inhibitors http://purl.obolibrary.org/obo/CHEBI_76790 EC 2.4.2.* (pentosyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76662 EC 2.4.* (glycosyltransferase) inhibitor pentosyltransferase inhibitors http://purl.obolibrary.org/obo/CHEBI_76817 EC 2.7.10.* (protein-tyrosine kinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76668 EC 2.7.* (P-containing group transferase) inhibitor protein-tyrosine kinase inhibitors http://purl.obolibrary.org/obo/CHEBI_76832 EC 4.3.1.* (ammonia-lyase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76713 EC 4.3.* (C-N lyase) inhibitor ammonia-lyase inhibitors http://purl.obolibrary.org/obo/CHEBI_76836 EC 1.1.3.* (oxidoreductase acting on donor CH-OH group, oxygen as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76726 EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor oxidoreductase acting on donor CH-OH group, oxygen as acceptor (EC 1.1.3.*) inhibitor http://purl.obolibrary.org/obo/CHEBI_76847 EC 1.14.16.* (oxidoreductase acting on paired donors, reduced pteridine as one donor, incorporating 1 atom of oxygen) inhibitor http://purl.obolibrary.org/obo/CHEBI_76741 EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor EC 1.14.16.* (oxidoreductase acting on paired donors, reduced pteridine as one donor, incorporating 1 atom of oxygen) inhibitors http://purl.obolibrary.org/obo/CHEBI_76853 EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76727 EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor EC 1.2.3.* (oxidoreductase acting on donor aldehyde/oxo group with oxygen as acceptor) inhibitors http://purl.obolibrary.org/obo/CHEBI_76874 EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitor http://purl.obolibrary.org/obo/CHEBI_76655 EC 2.1.* (C1-transferase) inhibitor hydroxymethyl-, formyl- and related transferases (EC 2.1.2.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_76882 EC 2.4.99.* (glycosyltransferases transferring other glycosyl groups) inhibitor http://purl.obolibrary.org/obo/CHEBI_76662 EC 2.4.* (glycosyltransferase) inhibitor glycosyltransferases transferring other glycosyl groups (EC 2.4.99.*) inhibitor http://purl.obolibrary.org/obo/CHEBI_76883 EC 3.11.1.* (hydrolases acting on C-P bonds of phosphono-acetaldehyde, -acetate, or -pyruvate) inhibitor http://purl.obolibrary.org/obo/CHEBI_76770 EC 3.11.* (hydrolases acting on C-P bonds) inhibitor EC 3.11.1.* (hydrolases acting on C-P bonds of phosphono-acetaldehyde, -acetate, or -pyruvate) inhibitors http://purl.obolibrary.org/obo/CHEBI_76939 EC 3.6.4.10 (non-chaperonin molecular chaperone ATPase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76938 EC 3.6.4.* (hydrolases acting on ATP; involved in cellular and subcellular movement) inhibitor ATP phosphohydrolase (polypeptide-polymerising) inhibitors http://purl.obolibrary.org/obo/CHEBI_76960 Chaetomium metabolite http://purl.obolibrary.org/obo/CHEBI_76946 fungal metabolite Chaetomium metabolites http://purl.obolibrary.org/obo/CHEBI_78031 Wnt signalling inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor Wnt-signalling inhibitors http://purl.obolibrary.org/obo/CHEBI_70724 cell dedifferentiation agent http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role cell dedifferentiation agents http://purl.obolibrary.org/obo/CHEBI_70725 adenosine A3 receptor antagonist http://purl.obolibrary.org/obo/CHEBI_71232 adenosine receptor antagonist adenosine A3 receptor antagonistS http://purl.obolibrary.org/obo/CHEBI_70817 EC 1.2.1.12 [glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)] inhibitor http://purl.obolibrary.org/obo/CHEBI_76852 EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor glyceraldehyde phosphate dehydrogenase (NAD) inhibitor http://purl.obolibrary.org/obo/CHEBI_70982 reactive oxygen species generator http://purl.obolibrary.org/obo/CHEBI_51086 chemical role reactive oxygen species generators http://purl.obolibrary.org/obo/CHEBI_71014 AMPA receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonists http://purl.obolibrary.org/obo/CHEBI_71027 progesterone receptor modulator http://purl.obolibrary.org/obo/CHEBI_51061 hormone receptor modulator progesterone receptor modulators http://purl.obolibrary.org/obo/CHEBI_71033 carbamylphosphate synthetase I activator http://purl.obolibrary.org/obo/CHEBI_35224 effector carbamylphosphate synthetase I activators http://purl.obolibrary.org/obo/CHEBI_71300 EC 2.* (transferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor transferase inhibitors http://purl.obolibrary.org/obo/CHEBI_72771 breast cancer resistance protein inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role breast cancer resistance protein inhibitors http://purl.obolibrary.org/obo/CHEBI_76824 EC 6.4.1.* (carboxylase) inhibitor http://purl.obolibrary.org/obo/CHEBI_75604 EC 6.4.* (C-C bond-forming ligase) inhibitor inhibitors of ligases forming C-C bonds http://purl.obolibrary.org/obo/CHEBI_76830 EC 5.99.1.* (miscellaneous isomerase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76697 EC 5.99.* (other isomerases) inhibitor EC 5.99.1.* inhibitors http://purl.obolibrary.org/obo/CHEBI_71551 EC 3.5.1.23 (ceramidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76807 EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor glycosphingolipid ceramide deacylase inhibitors http://purl.obolibrary.org/obo/CHEBI_71554 PPARgamma agonist http://purl.obolibrary.org/obo/CHEBI_70781 PPAR modulator peroxisome proliferator-activated receptor-gamma agonists http://purl.obolibrary.org/obo/CHEBI_72298 MTP inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role microsomal triglyceride transfer protein inhibitors http://purl.obolibrary.org/obo/CHEBI_72311 glucagon-like peptide-2 receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist glucagon-like peptide-2 receptor agonists http://purl.obolibrary.org/obo/CHEBI_73189 brassinosteroid biosynthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor brassinosteroid biosynthesis inhibitors http://purl.obolibrary.org/obo/CHEBI_73193 gibberellin biosynthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor gibberellin biosynthesis inhibitors http://purl.obolibrary.org/obo/CHEBI_73273 sodium-glucose transport protein subtype 2 inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role sodium-glucose transport protein subtype 2 inhibitors http://purl.obolibrary.org/obo/CHEBI_73310 adenosine A2A receptor agonist http://purl.obolibrary.org/obo/CHEBI_73311 adenosine receptor agonist adenosine A2A receptor agonists http://purl.obolibrary.org/obo/CHEBI_73319 adenosine A3 receptor agonist http://purl.obolibrary.org/obo/CHEBI_73311 adenosine receptor agonist adenosine A3 receptor agonists http://purl.obolibrary.org/obo/CHEBI_73334 thyroid hormone agonist http://purl.obolibrary.org/obo/CHEBI_51060 hormone agonist thyromimetics http://purl.obolibrary.org/obo/CHEBI_73360 EC 3.4.11.18 (methionyl aminopeptidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76787 EC 3.4.11.* (aminopeptidase) inhibitor peptidase M inhibitors http://purl.obolibrary.org/obo/CHEBI_73413 cannabinoid receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist cannabinoid receptor antagonists http://purl.obolibrary.org/obo/CHEBI_73417 CB2 receptor antagonist http://purl.obolibrary.org/obo/CHEBI_73413 cannabinoid receptor antagonist type 2 cannabinoid receptor antagonists http://purl.obolibrary.org/obo/CHEBI_75381 EC 1.11.1.* (peroxidases) inhibitor http://purl.obolibrary.org/obo/CHEBI_76738 EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor peroxidases inhibitors http://purl.obolibrary.org/obo/CHEBI_76818 EC 2.7.3.* (phosphotransferases with a nitrogenous group as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76668 EC 2.7.* (P-containing group transferase) inhibitor phosphotransferases with a nitrogenous group as acceptor (EC 2.7.3.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_76831 EC 4.4.1.* (C-S lyase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76714 EC 4.4.* (C-S lyase) inhibitor EC 4.4.1.* inhibitors http://purl.obolibrary.org/obo/CHEBI_76859 EC 1.3.99.* (oxidoreductase acting on donor CH-CH group, with other acceptors) inhibitor http://purl.obolibrary.org/obo/CHEBI_76729 EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor oxidoreductase acting on donor CH-CH group with other acceptors (EC 1.3.99.*) inhibitor http://purl.obolibrary.org/obo/CHEBI_76860 EC 1.3.3.* (oxidoreductase acting on donor CH-CH group, oxygen as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76729 EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor EC 1.3.3.* (oxidoreductase acting on donor CH-CH group, oxygen as acceptor) inhibitors http://purl.obolibrary.org/obo/CHEBI_76877 EC 2.3.2.* (aminoacyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76661 EC 2.3.* (acyltransferase) inhibitor aminoacyltransferase (EC 2.3.2.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_78927 EC 3.6.1.* (hydrolases acting on acid anhydrides in P-containing anhydrides) inhibitor http://purl.obolibrary.org/obo/CHEBI_73216 EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor EC 3.6.1.* (hydrolases acting on acid anhydrides in phosphorus-containing anhydrides) inhibitor http://purl.obolibrary.org/obo/CHEBI_79046 melatonin receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist melatonin receptor agonists http://purl.obolibrary.org/obo/CHEBI_79088 EC 3.4.24.35 (gelatinase B) inhibitor http://purl.obolibrary.org/obo/CHEBI_50664 matrix metalloproteinase inhibitor type V collagenase inhibitors http://purl.obolibrary.org/obo/CHEBI_79092 EC 1.11.2.* (oxidoreductase with H2O2 as acceptor, incorporating 1 O atom into product) inhibitor http://purl.obolibrary.org/obo/CHEBI_76738 EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor EC 1.11.2.* inhibitors http://purl.obolibrary.org/obo/CHEBI_79386 glycerophosphoinositol synthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_76932 pathway inhibitor glycerophosphoinositol synthesis inhibitors http://purl.obolibrary.org/obo/CHEBI_79392 EC 6.1.1.2 (tryptophan--tRNA ligase) inhibitor http://purl.obolibrary.org/obo/CHEBI_75416 EC 6.1.1.* (ligases forming aminoacyl tRNA and related compounds) inhibitor L-tryptophan:tRNA(Trp) ligase (AMP-forming) inhibitor http://purl.obolibrary.org/obo/CHEBI_83034 EC 4.1.2.27 (sphinganine-1-phosphate aldolase) inhibitor http://purl.obolibrary.org/obo/CHEBI_83035 EC 4.1.2.* (aldehyde-lyase) inhibitor EC 4.1.2.27 (sphinganine-1-phosphate aldolase) inhibitors http://purl.obolibrary.org/obo/CHEBI_85053 EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} activator http://purl.obolibrary.org/obo/CHEBI_35224 effector [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activators http://purl.obolibrary.org/obo/CHEBI_91016 GABAA receptor agonist http://purl.obolibrary.org/obo/CHEBI_51373 GABA agonist GABAA receptor agonists http://purl.obolibrary.org/obo/CHEBI_82756 EC 6.1.1.12 (aspartate--tRNA ligase) inhibitor http://purl.obolibrary.org/obo/CHEBI_75416 EC 6.1.1.* (ligases forming aminoacyl tRNA and related compounds) inhibitor aspartyl-transfer ribonucleic acid synthetase inhibitors http://purl.obolibrary.org/obo/CHEBI_82823 EC 3.4.22.54 (calpain-3) inhibitor http://purl.obolibrary.org/obo/CHEBI_82824 calpain inhibitor muscle-specific calcium-activated neutral protease 3 inhibitors http://purl.obolibrary.org/obo/CHEBI_83035 EC 4.1.2.* (aldehyde-lyase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76906 EC 4.1.1.* (carboxy-lyase) inhibitor EC 4.1.2.* inhibitors http://purl.obolibrary.org/obo/CHEBI_83057 Daphnia metabolite http://purl.obolibrary.org/obo/CHEBI_83039 crustacean metabolite Daphnia metabolites http://purl.obolibrary.org/obo/CHEBI_83074 kairomone http://purl.obolibrary.org/obo/CHEBI_26645 semiochemical kairomones http://purl.obolibrary.org/obo/CHEBI_83075 Daphnia pulex metabolite http://purl.obolibrary.org/obo/CHEBI_83057 Daphnia metabolite Daphnia pulex metabolites http://purl.obolibrary.org/obo/CHEBI_83156 EC 6.2.1.* (acid-thiol ligase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76707 EC 6.2.* (C-S bond-forming ligase) inhibitor EC 6.2.1.* inhibitors http://purl.obolibrary.org/obo/CHEBI_83157 EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor http://purl.obolibrary.org/obo/CHEBI_83156 EC 6.2.1.* (acid-thiol ligase) inhibitor long-chain fatty acyl coenzyme A synthetase inhibitor http://purl.obolibrary.org/obo/CHEBI_83296 orexin receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist orexin receptor antagonists http://purl.obolibrary.org/obo/CHEBI_83313 protease-activated receptor-1 antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist thrombin receptor antagonists http://purl.obolibrary.org/obo/CHEBI_83316 EC 1.14.13.72 (methylsterol monooxygenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76841 EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor methylsterol monooxygenase (EC 1.14.13.72) inhibitors http://purl.obolibrary.org/obo/CHEBI_83799 nonstructural protein 5A inhibitor http://purl.obolibrary.org/obo/CHEBI_22587 antiviral agent nonstructural protein 5A inhibitors http://purl.obolibrary.org/obo/CHEBI_90190 EC 2.1.1.37 [DNA (cytosine-5-)-methyltransferase] inhibitor http://purl.obolibrary.org/obo/CHEBI_76871 EC 2.1.1.* (methyltransferases) inhibitor deoxyribonucleic acid modification methylase inhibitor http://purl.obolibrary.org/obo/CHEBI_90199 c-Met tyrosine kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_62434 EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor MET proto-oncogene, receptor tyrosine kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_90285 EC 4.1.1.23 (orotidine-5'-phosphate decarboxylase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76906 EC 4.1.1.* (carboxy-lyase) inhibitor orotidine-5'-phosphate decarboxylase (EC 4.1.1.23) inhibitors http://purl.obolibrary.org/obo/CHEBI_90365 EC 4.6.1.1 (adenylate cyclase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76716 EC 4.6.* (P-O lyase) inhibitor ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) inhibitor http://purl.obolibrary.org/obo/CHEBI_90374 histone acetyltransferase activator http://purl.obolibrary.org/obo/CHEBI_35224 effector histone acetyltransferase activators http://purl.obolibrary.org/obo/CHEBI_90375 Sir1 inhibitor http://purl.obolibrary.org/obo/CHEBI_61115 EC 3.5.1.98 (histone deacetylase) inhibitor sirtuin 1 inhibitors http://purl.obolibrary.org/obo/CHEBI_90414 secretagogue http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role secretagogues http://purl.obolibrary.org/obo/CHEBI_90689 EC 5.3.1.* (intramolecular oxidoreductase interconverting aldoses and ketoses) inhibitor http://purl.obolibrary.org/obo/CHEBI_76694 EC 5.3.* (intramolecular oxidoreductase) inhibitor intramolecular oxidoreductase interconverting aldoses and ketoses (EC 5.3.1.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_90709 nuclear receptor modulator http://purl.obolibrary.org/obo/CHEBI_90710 receptor modulator nuclear receptor modulators http://purl.obolibrary.org/obo/CHEBI_90742 retinoic acid receptor beta agonist http://purl.obolibrary.org/obo/CHEBI_67198 retinoic acid receptor agonist retinoic acid receptor beta agonists http://purl.obolibrary.org/obo/CHEBI_90744 retinoic acid receptor gamma antagonist http://purl.obolibrary.org/obo/CHEBI_90714 retinoic acid receptor antagonist retinoic acid receptor gamma antagonists http://purl.obolibrary.org/obo/CHEBI_90767 eukaryotic translation elongation factor 1alpha 1 inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role eEF1A inhibitors http://purl.obolibrary.org/obo/CHEBI_90780 AKT1 kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_50925 EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor RAC-alpha serine/threonine-protein kinase inhibitors http://purl.obolibrary.org/obo/CHEBI_90845 prostacyclin receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist prostacyclin receptor agonists http://purl.obolibrary.org/obo/CHEBI_90846 liver X receptor inverse agonist http://purl.obolibrary.org/obo/CHEBI_90847 inverse agonist liver X receptor inverse agonists http://purl.obolibrary.org/obo/CHEBI_90878 EC 2.4.2.4 (thymidine phosphorylase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76790 EC 2.4.2.* (pentosyltransferase) inhibitor pyrimidine deoxynucleoside phosphorylase inhibitors http://purl.obolibrary.org/obo/CHEBI_90920 EC 1.8.5.* (oxidoreductase acting on sulfur group donors, quinone or similar as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76735 EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor EC 1.8.5.* (oxidoreductase acting on sulfur group donors, quinone or similar as acceptor) inhibitors http://purl.obolibrary.org/obo/CHEBI_90921 EC 1.8.5.4 (sulfide:quinone reductase) inhibitor http://purl.obolibrary.org/obo/CHEBI_90920 EC 1.8.5.* (oxidoreductase acting on sulfur group donors, quinone or similar as acceptor) inhibitor sulfide:quinone reductase inhibitors http://purl.obolibrary.org/obo/CHEBI_90961 ERK dimerisation inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor extracellular signal-regulated kinase dimerisation inhibitor http://purl.obolibrary.org/obo/CHEBI_90991 steroid receptor coactivator stimulator http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role steroid receptor coactivator small molecule stimulator http://purl.obolibrary.org/obo/CHEBI_91142 EC 1.1.5.* (oxidoreductase acting on donor CH-OH group, quinone or similar compound as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76726 EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor oxidoreductase acting on donor CH-OH group, quinone or simliar compound as acceptor (EC 1.1.5.*) inhibitor http://purl.obolibrary.org/obo/CHEBI_91189 VEGF activator http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role vascular endothelial growth factor inducers http://purl.obolibrary.org/obo/CHEBI_91193 lysophosphatidic acid receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist lysophosphatidic acid receptor antagonists http://purl.obolibrary.org/obo/CHEBI_91214 macrophage migration inhibitory factor inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role macrophage migration inhibitory factor inhibitors http://purl.obolibrary.org/obo/CLO_0007203 L6 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 L6 http://purl.obolibrary.org/obo/CLO_0007606 MCF7 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 MCF7 http://purl.obolibrary.org/obo/CLO_0007634 MDA-MB-231 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 MDA-MB-231 http://purl.obolibrary.org/obo/CLO_0007646 MDCK 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 MDCK http://purl.obolibrary.org/obo/CLO_0007657 ME-180 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 ME-180 http://purl.obolibrary.org/obo/CLO_0007865 MRC-5 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 MRC-5 http://purl.obolibrary.org/obo/CLO_0007904 Mv 1 Lu 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 Mv 1 Lu http://purl.obolibrary.org/obo/CLO_0008172 NIH-3T3 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 NIH-3T3 http://purl.obolibrary.org/obo/CLO_0009015 SH-SY5Y 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 SH-SY5Y http://purl.obolibrary.org/obo/CLO_0009059 SK-N-SH 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 SK-N-SH http://purl.obolibrary.org/obo/CLO_0009215 SW403 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 SW403 http://purl.obolibrary.org/obo/CLO_0009348 THP-1 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 THP-1 http://purl.obolibrary.org/obo/CLO_0009454 U-2 OS 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 U2OS http://purl.obolibrary.org/obo/CLO_0009463 obsolete: U87 MG cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 U87 MG http://purl.obolibrary.org/obo/CLO_0009524 Vero 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 Vero http://purl.obolibrary.org/obo/CLO_0009526 VERO 76 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 VERO 76 http://purl.obolibrary.org/obo/CLO_0009527 VERO C1008 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 VERO C1008 http://purl.obolibrary.org/obo/NCBITaxon_102793 H5N1 subtype http://www.bioassayontology.org/bao#BAO_0000232 virus H5N1 http://purl.obolibrary.org/obo/NCBITaxon_210 Helicobacter pylori http://www.bioassayontology.org/bao#BAO_0000364 bacterium Helicobacter nemestrinae http://purl.obolibrary.org/obo/NCBITaxon_10906 Bluetongue virus 10 http://www.bioassayontology.org/bao#BAO_0000232 virus Bluetongue virus type 10 http://www.bioassayontology.org/bao#BAO_0001061 guanosine triphosphate http://www.bioassayontology.org/bao#BAO_0002010 nucleotide GTP http://purl.obolibrary.org/obo/CHEBI_136537 EC 2.4.2.8 (hypoxanthine phosphoribosyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76790 EC 2.4.2.* (pentosyltransferase) inhibitor EC 2.4.2.8 (hypoxanthine phosphoribosyltransferase) inhibitors http://purl.obolibrary.org/obo/CHEBI_136643 propesticide http://purl.obolibrary.org/obo/CHEBI_136859 pro-agent propesticides http://purl.obolibrary.org/obo/CHEBI_136644 proinsecticide http://purl.obolibrary.org/obo/CHEBI_136643 propesticide proinsecticides http://purl.obolibrary.org/obo/CHEBI_136645 profungicide http://purl.obolibrary.org/obo/CHEBI_24127 fungicide profungicides http://purl.obolibrary.org/obo/CHEBI_136646 proherbicide http://purl.obolibrary.org/obo/CHEBI_136643 propesticide proherbicides http://purl.obolibrary.org/obo/CHEBI_136647 proacaricide http://purl.obolibrary.org/obo/CHEBI_22153 acaricide proacaricides http://purl.obolibrary.org/obo/CHEBI_136648 prosafener http://purl.obolibrary.org/obo/CHEBI_136643 propesticide prosafeners http://purl.obolibrary.org/obo/CHEBI_136651 S100 calcium-binding protein B inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role S100B inhibitors http://purl.obolibrary.org/obo/CHEBI_136859 pro-agent http://purl.obolibrary.org/obo/CHEBI_33232 application proagents http://purl.obolibrary.org/obo/CHEBI_136580 LRH-1 antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist LRH-1 antagonists http://www.bioassayontology.org/bao#BAO_0000204 Interleukin-6 http://www.bioassayontology.org/bao#BAO_0000369 secreted IL-6 http://purl.obolibrary.org/obo/NCBITaxon_10245 Vaccinia virus http://www.bioassayontology.org/bao#BAO_0000232 virus vaccinia virus VV http://purl.obolibrary.org/obo/NCBITaxon_11036 Venezuelan equine encephalitis virus http://www.bioassayontology.org/bao#BAO_0000232 virus Venezuelan equine encephalomyelitis virus http://purl.obolibrary.org/obo/NCBITaxon_11103 Hepacivirus C http://www.bioassayontology.org/bao#BAO_0000232 virus post-transfusion hepatitis non A non B virus http://purl.obolibrary.org/obo/NCBITaxon_11620 Lassa mammarenavirus http://www.bioassayontology.org/bao#BAO_0000232 virus Lassa virus http://purl.obolibrary.org/obo/NCBITaxon_11676 Human immunodeficiency virus 1 http://www.bioassayontology.org/bao#BAO_0000232 virus human immunodeficiency virus-1 HIV-1 http://purl.obolibrary.org/obo/NCBITaxon_1773 Mycobacterium tuberculosis http://www.bioassayontology.org/bao#BAO_0000364 bacterium Mycobacterium tuberculosis variant tuberculosis http://purl.obolibrary.org/obo/NCBITaxon_3702 Arabidopsis thaliana http://www.bioassayontology.org/bao#BAO_0000605 plant thale-cress http://purl.obolibrary.org/obo/NCBITaxon_4932 Saccharomyces cerevisiae http://www.bioassayontology.org/bao#BAO_0000233 unicellular fungi Mycoderma cerevisiae http://purl.obolibrary.org/obo/NCBITaxon_6239 Caenorhabditis elegans http://www.bioassayontology.org/bao#BAO_0000511 invertebrate roundworm http://purl.obolibrary.org/obo/NCBITaxon_7227 Drosophila melanogaster http://www.bioassayontology.org/bao#BAO_0000511 invertebrate Sophophora melanogaster http://purl.obolibrary.org/obo/NCBITaxon_9606 Homo sapiens http://www.bioassayontology.org/bao#BAO_0000362 mammalian man http://www.bioassayontology.org/bao#BAO_0000762 Interleukin-3 http://www.bioassayontology.org/bao#BAO_0000369 secreted IL-3 http://www.bioassayontology.org/bao#BAO_0002720 MES http://www.bioassayontology.org/bao#BAO_0003043 molecular entity 2-(N-morpholino)ethanesulfonic acid http://purl.obolibrary.org/obo/CHEBI_134545 EC 1.8.1.4 (dihydrolipoyl dehydrogenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_77402 EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor EC 1.8.1.4 (dihydrolipoyl dehydrogenase) inhibitors http://purl.obolibrary.org/obo/CLO_0037254 DPX2 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 DPX-2 http://purl.obolibrary.org/obo/CHEBI_110725 EC 2.1.1.8 (histamine N-methyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76871 EC 2.1.1.* (methyltransferases) inhibitor EC 2.1.1.8 (histamine N-methyltransferase) inhibitors http://purl.obolibrary.org/obo/CHEBI_50113 androgen http://purl.obolibrary.org/obo/CHEBI_50112 sex hormone androgens http://purl.obolibrary.org/obo/CHEBI_50114 estrogen http://purl.obolibrary.org/obo/CHEBI_50112 sex hormone oestrogens http://purl.obolibrary.org/obo/CHEBI_50646 bone density conservation agent http://purl.obolibrary.org/obo/CHEBI_23888 drug bone density conservation drugs http://purl.obolibrary.org/obo/CHEBI_75772 Saccharomyces cerevisiae metabolite http://purl.obolibrary.org/obo/CHEBI_76946 fungal metabolite baker's yeast secondary metabolites http://purl.obolibrary.org/obo/CHEBI_76507 marine metabolite http://purl.obolibrary.org/obo/CHEBI_25212 metabolite marine metabolites http://purl.obolibrary.org/obo/CHEBI_76871 EC 2.1.1.* (methyltransferases) inhibitor http://purl.obolibrary.org/obo/CHEBI_76655 EC 2.1.* (C1-transferase) inhibitor methyltransferase (EC 2.1.1.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_85234 human blood serum metabolite http://purl.obolibrary.org/obo/CHEBI_77746 human metabolite human blood serum metabolites http://purl.obolibrary.org/obo/CHEBI_35482 opioid analgesic http://purl.obolibrary.org/obo/CHEBI_35480 analgesic opioid analgesics http://purl.obolibrary.org/obo/CHEBI_38317 EC 1.13.11.27 (4-hydroxyphenylpyruvate dioxygenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76837 EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor 4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating) inhibitors http://purl.obolibrary.org/obo/CHEBI_38867 anaesthetic http://purl.obolibrary.org/obo/CHEBI_23888 drug anesthetics http://purl.obolibrary.org/obo/CHEBI_55322 mu-opioid receptor agonist http://purl.obolibrary.org/obo/CHEBI_60606 opioid receptor agonist mu-opioid receptor agonists http://purl.obolibrary.org/obo/CHEBI_60807 anaesthesia adjuvant http://purl.obolibrary.org/obo/CHEBI_60809 adjuvant anaesthestic adjuvants http://purl.obolibrary.org/obo/CHEBI_60809 adjuvant http://purl.obolibrary.org/obo/CHEBI_52217 pharmaceutical adjuvants http://purl.obolibrary.org/obo/CHEBI_72768 aryl hydrocarbon receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist aryl hydrocarbon receptor agonists http://purl.obolibrary.org/obo/CHEBI_76206 xenobiotic metabolite http://purl.obolibrary.org/obo/CHEBI_25212 metabolite xenobiotic metabolites http://purl.obolibrary.org/obo/CHEBI_132972 farnesoid X receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist farnesoid X receptor agonists http://purl.obolibrary.org/obo/CHEBI_132992 radiosensitizing agent http://purl.obolibrary.org/obo/CHEBI_23888 drug radiosensitizing agents http://purl.obolibrary.org/obo/CHEBI_133016 5-hydroxytryptamine 2A receptor inverse agonist http://purl.obolibrary.org/obo/CHEBI_90847 inverse agonist 5HT2Ainverse agonist http://purl.obolibrary.org/obo/CHEBI_133022 B-cell lymphoma 2 inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role Bcl-2 inhibitors http://purl.obolibrary.org/obo/CHEBI_133024 lymphocyte function-associated antigen-1 antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist lymphocyte function-associated antigen-1 antagonists http://purl.obolibrary.org/obo/CHEBI_133106 chemical hybridisation agent http://purl.obolibrary.org/obo/CHEBI_26155 plant growth regulator chemical hybridization agents http://purl.obolibrary.org/obo/CHEBI_133190 fatty acid oxidation inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role fatty acid oxidation inhibitors http://purl.obolibrary.org/obo/CHEBI_133878 neuropeptide Y receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist neuropeptide Y receptor antagonists http://purl.obolibrary.org/obo/CHEBI_133891 salt-inducible kinase 2 inhibitor http://purl.obolibrary.org/obo/CHEBI_37699 protein kinase inhibitor serine/threonine-protein kinase SIK2 inhibitor http://purl.obolibrary.org/obo/CHEBI_133895 EC 2.5.1.46 (deoxyhypusine synthase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76663 EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor spermidine:eIF5A-lysine 4-aminobutyltransferase (propane-1,3-diamine-forming) inhibitors http://purl.obolibrary.org/obo/CHEBI_134083 hypoxia-inducible factor pathway activator http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role hypoxia-inducible factor pathway activators http://purl.obolibrary.org/obo/CHEBI_134084 EC 1.15.1.1 (superoxide dismutase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76742 EC 1.15.* (oxidoreductase acting on superoxide as acceptor) inhibitor superoxide:superoxide oxidoreductase inhibitors http://purl.obolibrary.org/obo/CHEBI_134108 lipopolysaccharide biosynthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role lipopolysaccharide biosynthesis inhibitors http://purl.obolibrary.org/obo/CHEBI_134109 EC 3.5.1.108 (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76807 EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase inhibitors http://purl.obolibrary.org/obo/CHEBI_134173 antidote to barbiturate poisoning http://purl.obolibrary.org/obo/CHEBI_50247 antidote antidote to barbiturate overdose http://purl.obolibrary.org/obo/CHEBI_15022 electron donor http://purl.obolibrary.org/obo/CHEBI_17891 donor electron donor http://purl.obolibrary.org/obo/CHEBI_15339 acceptor http://purl.obolibrary.org/obo/CHEBI_51086 chemical role acceptor http://purl.obolibrary.org/obo/CHEBI_17891 donor http://purl.obolibrary.org/obo/CHEBI_51086 chemical role donor http://purl.obolibrary.org/obo/CHEBI_22153 acaricide http://purl.obolibrary.org/obo/CHEBI_25944 pesticide miticide http://purl.obolibrary.org/obo/CHEBI_23888 drug http://purl.obolibrary.org/obo/CHEBI_52217 pharmaceutical medicine http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role inhibiteurs enzymatiques http://purl.obolibrary.org/obo/CHEBI_24621 hormone http://purl.obolibrary.org/obo/CHEBI_33280 molecular messenger hormones http://purl.obolibrary.org/obo/CHEBI_25442 mycotoxin http://purl.obolibrary.org/obo/CHEBI_76946 fungal metabolite mycotoxins http://purl.obolibrary.org/obo/CHEBI_25728 osmolyte http://purl.obolibrary.org/obo/CHEBI_24432 biological role osmolytes http://purl.obolibrary.org/obo/CHEBI_26348 prosthetic group http://purl.obolibrary.org/obo/CHEBI_23357 cofactor prosthetic groups http://purl.obolibrary.org/obo/CHEBI_26672 siderophore http://purl.obolibrary.org/obo/CHEBI_24874 iron ionophore siderophores http://purl.obolibrary.org/obo/CHEBI_27027 micronutrient http://purl.obolibrary.org/obo/CHEBI_33284 nutrient trace elements http://purl.obolibrary.org/obo/CHEBI_33284 nutrient http://purl.obolibrary.org/obo/CHEBI_78295 food component nutrients http://purl.obolibrary.org/obo/CHEBI_35443 anthelminthic drug http://purl.obolibrary.org/obo/CHEBI_35442 antiparasitic agent antihelmintico http://purl.obolibrary.org/obo/CHEBI_35522 beta-adrenergic agonist http://purl.obolibrary.org/obo/CHEBI_48540 beta-adrenergic drug beta-adrenoceptor agonists http://purl.obolibrary.org/obo/CHEBI_35524 sympathomimetic agent http://purl.obolibrary.org/obo/CHEBI_37962 adrenergic agent sympathomimetics http://purl.obolibrary.org/obo/CHEBI_35554 cardiovascular drug http://purl.obolibrary.org/obo/CHEBI_23888 drug cardiovascular drugs http://purl.obolibrary.org/obo/CHEBI_35820 antiprotozoal drug http://purl.obolibrary.org/obo/CHEBI_36043 antimicrobial drug antiprotozoal drugs http://purl.obolibrary.org/obo/CHEBI_36063 oxytocic http://purl.obolibrary.org/obo/CHEBI_23888 drug uterine stimulants http://purl.obolibrary.org/obo/CHEBI_37338 radioopaque medium http://purl.obolibrary.org/obo/CHEBI_37334 diagnostic imaging agent radiopaque medium http://purl.obolibrary.org/obo/CHEBI_37527 acid http://purl.obolibrary.org/obo/CHEBI_51086 chemical role an acid http://purl.obolibrary.org/obo/CHEBI_37700 EC 2.7.11.13 (protein kinase C) inhibitor http://purl.obolibrary.org/obo/CHEBI_76812 EC 2.7.11.* (protein-serine/threonine kinase) inhibitor calcium/phospholipid dependent protein kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_38068 antimalarial http://purl.obolibrary.org/obo/CHEBI_64915 antiplasmodial drug antimalarials http://purl.obolibrary.org/obo/CHEBI_38324 cholinergic agonist http://purl.obolibrary.org/obo/CHEBI_38323 cholinergic drug cholinomimetics http://purl.obolibrary.org/obo/CHEBI_38999 GABA-gated chloride channel antagonist http://purl.obolibrary.org/obo/CHEBI_38632 membrane transport modulator GABA-gated chloride channel antagonists http://purl.obolibrary.org/obo/CHEBI_47958 nicotinic acetylcholine receptor agonist http://purl.obolibrary.org/obo/CHEBI_38324 cholinergic agonist nicotinic agonists http://purl.obolibrary.org/obo/CHEBI_48001 protein synthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_76932 pathway inhibitor protein synthesis inhibitors http://purl.obolibrary.org/obo/CHEBI_48358 polar aprotic solvent http://purl.obolibrary.org/obo/CHEBI_48357 aprotic solvent dipolar aprotic solvent http://purl.obolibrary.org/obo/CHEBI_48360 amphiprotic solvent http://purl.obolibrary.org/obo/CHEBI_48359 protophilic solvent amphiprotic solvent http://purl.obolibrary.org/obo/CHEBI_48675 antifibrinolytic drug http://purl.obolibrary.org/obo/CHEBI_48676 fibrin modulating drug antifibrinolytic drugs http://purl.obolibrary.org/obo/CHEBI_48887 bile acid metabolite http://purl.obolibrary.org/obo/CHEBI_25212 metabolite bile salt metabolite http://purl.obolibrary.org/obo/CHEBI_49023 prostaglandin antagonist http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist prostaglandin inhibitor http://purl.obolibrary.org/obo/CHEBI_49110 peripheral nervous system drug http://purl.obolibrary.org/obo/CHEBI_23888 drug peripheral nervous system drugs http://purl.obolibrary.org/obo/CHEBI_50247 antidote http://purl.obolibrary.org/obo/CHEBI_50267 protective agent antidotes http://purl.obolibrary.org/obo/CHEBI_50566 nitric oxide donor http://purl.obolibrary.org/obo/CHEBI_17891 donor nitric oxide releasing agents http://purl.obolibrary.org/obo/CHEBI_50630 cyclooxygenase 1 inhibitor http://purl.obolibrary.org/obo/CHEBI_35544 EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor prostaglandin-endoperoxide synthase 1 inhibitors http://purl.obolibrary.org/obo/CHEBI_50905 teratogenic agent http://purl.obolibrary.org/obo/CHEBI_52209 aetiopathogenetic role teratogeno http://purl.obolibrary.org/obo/CHEBI_50910 neurotoxin http://purl.obolibrary.org/obo/CHEBI_52209 aetiopathogenetic role neurotoxins http://purl.obolibrary.org/obo/CHEBI_50912 cardiotoxic agent http://purl.obolibrary.org/obo/CHEBI_52209 aetiopathogenetic role cardiotoxicant http://purl.obolibrary.org/obo/CHEBI_51177 antitussive http://purl.obolibrary.org/obo/CHEBI_23888 drug cough suppressants http://purl.obolibrary.org/obo/CHEBI_51371 muscle relaxant http://purl.obolibrary.org/obo/CHEBI_51372 neuromuscular agent muscle relaxants http://purl.obolibrary.org/obo/CHEBI_52726 proteasome inhibitor http://purl.obolibrary.org/obo/CHEBI_23888 drug proteasome inhibitors http://purl.obolibrary.org/obo/CHEBI_53431 chain carrier http://purl.obolibrary.org/obo/CHEBI_51086 chemical role chain carriers http://purl.obolibrary.org/obo/CHEBI_53784 antispasmodic drug http://purl.obolibrary.org/obo/CHEBI_51371 muscle relaxant antispasmodics http://purl.obolibrary.org/obo/CHEBI_55350 neurokinin-1 receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist neurokinin-1 receptor antagonists http://purl.obolibrary.org/obo/CHEBI_59174 hapten http://purl.obolibrary.org/obo/CHEBI_24432 biological role haptens http://purl.obolibrary.org/obo/CHEBI_59740 nucleophilic reagent http://purl.obolibrary.org/obo/CHEBI_39144 Lewis base nucleophilic reagents http://purl.obolibrary.org/obo/CHEBI_60643 NMDA receptor antagonist http://purl.obolibrary.org/obo/CHEBI_60798 excitatory amino acid antagonist NMDAR antagonists http://purl.obolibrary.org/obo/CHEBI_63156 EC 1.1.3.13 (alcohol oxidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76836 EC 1.1.3.* (oxidoreductase acting on donor CH-OH group, oxygen as acceptor) inhibitor ethanol oxidase inhibitors http://purl.obolibrary.org/obo/CHEBI_63157 EC 4.2.1.22 (cystathionine beta-synthase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76907 EC 4.2.1.* (hydro-lyases) inhibitor L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming) inhibitors http://purl.obolibrary.org/obo/CHEBI_63158 EC 2.3.1.21 (carnitine O-palmitoyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76878 EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor carnitine O-palmitoyltransferase (EC 2.3.1.21) inhibitors http://purl.obolibrary.org/obo/CHEBI_63248 oxidising agent http://purl.obolibrary.org/obo/CHEBI_51086 chemical role oxidizing agents http://purl.obolibrary.org/obo/CHEBI_63794 retinoid X receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist retinoid X receptor agonists http://purl.obolibrary.org/obo/CHEBI_63958 cellulose synthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_76932 pathway inhibitor cellulose synthesis inhibitors http://purl.obolibrary.org/obo/CHEBI_64570 EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76874 EC 2.1.2.* (hydroxymethyl-, formyl- and related transferases) inhibitor EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitors http://purl.obolibrary.org/obo/CHEBI_64584 uremic toxin http://purl.obolibrary.org/obo/CHEBI_27026 toxin uremic toxins http://purl.obolibrary.org/obo/CHEBI_64588 glycine transporter 1 inhibitor http://purl.obolibrary.org/obo/CHEBI_85425 glycine transporter inhibitor glycine transporter 1 inhibitors http://purl.obolibrary.org/obo/CHEBI_64589 glycine receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist glycine receptor agonists http://purl.obolibrary.org/obo/CHEBI_64697 acyl-CoA:cholesterol acyltransferase 2 inhibitor http://purl.obolibrary.org/obo/CHEBI_64696 EC 2.3.1.26 (sterol O-acyltransferase) inhibitor acyl-CoA:cholesterol acyltransferase 2 inhibitors http://purl.obolibrary.org/obo/CHEBI_64911 antimitotic http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role mitotic inhibitors http://purl.obolibrary.org/obo/CHEBI_64924 hepatitis C protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670 protease inhibitor hepatitis C protease inhibitors http://purl.obolibrary.org/obo/CHEBI_66987 radiation protective agent http://purl.obolibrary.org/obo/CHEBI_50267 protective agent radiation protective drugs http://purl.obolibrary.org/obo/CHEBI_66993 tocolytic agent http://purl.obolibrary.org/obo/CHEBI_50689 reproductive control drug tocolytics http://purl.obolibrary.org/obo/CHEBI_67198 retinoic acid receptor agonist http://purl.obolibrary.org/obo/CHEBI_90708 retinoic acid receptor modulator retinoic acid receptor agonists http://purl.obolibrary.org/obo/CHEBI_67199 AP-1 antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist activator protein-1 antagonists http://purl.obolibrary.org/obo/CHEBI_71476 EC 2.3.1.85 (fatty acid synthase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76878 EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing) inhibitors http://purl.obolibrary.org/obo/CHEBI_73182 plant activator http://purl.obolibrary.org/obo/CHEBI_33286 agrochemical plant activators http://purl.obolibrary.org/obo/CHEBI_73336 vulnerary http://purl.obolibrary.org/obo/CHEBI_23888 drug wound-healing drugs http://purl.obolibrary.org/obo/CHEBI_76395 EC 2.3.1.48 (histone acetyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76878 EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor nucleosome-histone acetyltransferase inhibitors http://purl.obolibrary.org/obo/CHEBI_76413 greenhouse gas http://purl.obolibrary.org/obo/CHEBI_51086 chemical role greenhouse gases http://purl.obolibrary.org/obo/CHEBI_76663 EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76834 EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitors http://purl.obolibrary.org/obo/CHEBI_76742 EC 1.15.* (oxidoreductase acting on superoxide as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor inhibitor of oxidoreductase acting on superoxide as acceptor http://purl.obolibrary.org/obo/CHEBI_76789 EC 2.4.1.* (hexosyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76662 EC 2.4.* (glycosyltransferase) inhibitor hexosyltransferase inhibitors http://purl.obolibrary.org/obo/CHEBI_76807 EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76764 EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor non-peptide linear amide C-N hydrolase (EC 3.5.1.*) inhibitor http://purl.obolibrary.org/obo/CHEBI_76964 Penicillium metabolite http://purl.obolibrary.org/obo/CHEBI_76946 fungal metabolite Penicillium metabolites http://purl.obolibrary.org/obo/CHEBI_76968 fungal xenobiotic metabolite http://purl.obolibrary.org/obo/CHEBI_76946 fungal metabolite fungal xenobiotic metabolites http://purl.obolibrary.org/obo/CHEBI_76989 phytoestrogen http://purl.obolibrary.org/obo/CHEBI_50114 estrogen phytoestrogens http://purl.obolibrary.org/obo/CHEBI_77090 EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76832 EC 4.3.1.* (ammonia-lyase) inhibitor EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitors http://purl.obolibrary.org/obo/CHEBI_77425 EC 1.1.1.188 (prostaglandin-F synthase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76835 EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor NADPH-dependent prostaglandin D2 11-keto reductase inhibitors http://purl.obolibrary.org/obo/CHEBI_77495 bradykinin receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist bradykinin receptor agonists http://purl.obolibrary.org/obo/CHEBI_77496 bradykinin receptor B2 agonist http://purl.obolibrary.org/obo/CHEBI_77495 bradykinin receptor agonist bradykinin receptor B2 agonists http://purl.obolibrary.org/obo/CHEBI_77523 Maillard reaction product http://purl.obolibrary.org/obo/CHEBI_77521 thermal degradation product maillard reaction products http://purl.obolibrary.org/obo/CHEBI_77715 nasal decongestant http://purl.obolibrary.org/obo/CHEBI_23888 drug nasal decongestants http://purl.obolibrary.org/obo/CHEBI_77853 persistent organic pollutant http://purl.obolibrary.org/obo/CHEBI_78298 environmental contaminant persistent organic pollutants http://purl.obolibrary.org/obo/CHEBI_77881 EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76832 EC 4.3.1.* (ammonia-lyase) inhibitor 2,3-diaminopropanoate ammonia-lyase (adding water; pyruvate-forming) inhibitor http://purl.obolibrary.org/obo/CHEBI_77941 EC 3.5.1.4 (amidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76807 EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor fatty acylamidase inhibitors http://purl.obolibrary.org/obo/CHEBI_77974 food packaging gas http://purl.obolibrary.org/obo/CHEBI_64047 food additive food packaging gases http://purl.obolibrary.org/obo/CHEBI_78675 fundamental metabolite http://purl.obolibrary.org/obo/CHEBI_25212 metabolite fundamental metabolites http://purl.obolibrary.org/obo/CHEBI_78803 nematode metabolite http://purl.obolibrary.org/obo/CHEBI_75767 animal metabolite nematode metabolites http://purl.obolibrary.org/obo/CHEBI_79091 EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76812 EC 2.7.11.* (protein-serine/threonine kinase) inhibitor EC 2.7.11.24 (mitogen-activated protein kinase) inhibitors http://purl.obolibrary.org/obo/CHEBI_79314 flame retardant http://purl.obolibrary.org/obo/CHEBI_33232 application flame retardants http://purl.obolibrary.org/obo/CHEBI_82655 animal growth promotant http://purl.obolibrary.org/obo/CHEBI_33286 agrochemical animal growth promoters http://purl.obolibrary.org/obo/CHEBI_82933 gut flora metabolite http://purl.obolibrary.org/obo/CHEBI_25212 metabolite gut flora metabolites http://purl.obolibrary.org/obo/CHEBI_85185 hepatitis C virus nonstructural protein 5A inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role hepatitis C virus nonstructural protein 5A inhibitors http://purl.obolibrary.org/obo/CHEBI_90847 inverse agonist http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role inverse agonists http://purl.obolibrary.org/obo/CHEBI_37886 adrenergic agonist http://purl.obolibrary.org/obo/CHEBI_37962 adrenergic agent adrenomimetics http://purl.obolibrary.org/obo/CHEBI_38060 triazine insecticide http://purl.obolibrary.org/obo/CHEBI_24852 insecticide triazine insecticides http://purl.obolibrary.org/obo/CHEBI_39143 Lewis acid http://purl.obolibrary.org/obo/CHEBI_37527 acid electron-pair acceptor http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist hormone antagonists http://purl.obolibrary.org/obo/CHEBI_50745 progestogen http://purl.obolibrary.org/obo/CHEBI_50112 sex hormone progestogens http://purl.obolibrary.org/obo/CHEBI_51121 fluorescent dye http://purl.obolibrary.org/obo/CHEBI_37958 dye fluorescent dyes http://purl.obolibrary.org/obo/CHEBI_61950 microtubule-stabilising agent http://purl.obolibrary.org/obo/CHEBI_60832 tubulin modulator microtubule-stabilizing agent http://purl.obolibrary.org/obo/CHEBI_62754 glycine receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist glycine receptor antagonists http://purl.obolibrary.org/obo/CHEBI_64237 EC 2.7.8.15 (UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76816 EC 2.7.8.* (transferases for other substituted phosphate groups) inhibitor N-acetylglucosamine-1-phosphate transferase inhibitors http://purl.obolibrary.org/obo/CHEBI_64670 EC 1.8.1.9 (thioredoxin reductase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76869 EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitor thioredoxin:NADP+ oxidoreductase inhibitors http://purl.obolibrary.org/obo/CHEBI_64857 cosmetic http://purl.obolibrary.org/obo/CHEBI_33232 application cosmetics http://purl.obolibrary.org/obo/CHEBI_64995 EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_35856 lipoxygenase inhibitor EC 1.13.11.31 (arachidonate 12-lipoxygenase) inhibitors http://purl.obolibrary.org/obo/CHEBI_66991 sympatholytic agent http://purl.obolibrary.org/obo/CHEBI_37962 adrenergic agent sympatholytics http://purl.obolibrary.org/obo/CHEBI_75599 EC 6.3.2.2 (glutamate--cysteine ligase) inhibitor http://purl.obolibrary.org/obo/CHEBI_59105 EC 6.3.2.* (acid--D-amino-acid ligase) inhibitor glutamate--cysteine ligase inhibitors http://purl.obolibrary.org/obo/CHEBI_78379 EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76663 EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor pyruvate-uridine diphospho-N-acetylglucosamine transferase inhibitor http://purl.obolibrary.org/obo/CHEBI_83757 EC 2.4.1.231 [alpha,alpha-trehalose phosphorylase (configuration-retaining)] inhibitor http://purl.obolibrary.org/obo/CHEBI_76789 EC 2.4.1.* (hexosyltransferase) inhibitor alpha,alpha-trehalose:phosphate alpha-D-glucosyltransferase inhibitors http://purl.obolibrary.org/obo/CHEBI_83760 EC 2.4.1.64 (alpha,alpha-trehalose phosphorylase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76789 EC 2.4.1.* (hexosyltransferase) inhibitor alpha,alpha-trehalose:phosphate beta-D-glucosyltransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_39369 pyrethroid ether acaricide http://purl.obolibrary.org/obo/CHEBI_22153 acaricide pyrethroid ether acaricides http://purl.obolibrary.org/obo/CHEBI_59727 vasopressin receptor agonist http://purl.obolibrary.org/obo/CHEBI_51060 hormone agonist vasopressin receptor agonists http://purl.obolibrary.org/obo/CHEBI_59745 chromatographic reagent http://purl.obolibrary.org/obo/CHEBI_33893 reagent derivatizing reagents http://purl.obolibrary.org/obo/CHEBI_63054 osteogenesis regulator http://purl.obolibrary.org/obo/CHEBI_39317 growth regulator osteogenesis regulators http://purl.obolibrary.org/obo/CHEBI_63090 EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76790 EC 2.4.2.* (pentosyltransferase) inhibitor purine-nucleoside phosphorylase (EC 2.4.2.1) inhibitor http://purl.obolibrary.org/obo/CHEBI_63963 metabotropic glutamate receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist metabotropic glutamate receptor antagonists http://purl.obolibrary.org/obo/CHEBI_64102 AMPA receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist quisqualate receptor agonist http://purl.obolibrary.org/obo/CHEBI_64297 reaction intermediate http://purl.obolibrary.org/obo/CHEBI_51086 chemical role chemical intermediate http://purl.obolibrary.org/obo/CHEBI_64922 EC 3.4.21.37 (leukocyte elastase) inhibitor http://purl.obolibrary.org/obo/CHEBI_5924 EC 3.4.21.* (serine endopeptidase) inhibitor serine elastase inhibitors http://purl.obolibrary.org/obo/CHEBI_64926 serine protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670 protease inhibitor serine protease inhibitors http://purl.obolibrary.org/obo/CHEBI_71338 autoinducer http://purl.obolibrary.org/obo/CHEBI_62488 signalling molecule autoinducers http://purl.obolibrary.org/obo/CHEBI_72470 provitamin B1 http://purl.obolibrary.org/obo/CHEBI_50188 provitamin provitamin B1s http://purl.obolibrary.org/obo/CHEBI_73267 oxidative phosphorylation inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor oxidative phosphorylation inhibitors http://purl.obolibrary.org/obo/CHEBI_75380 EC 1.11.1.6 (catalase) inhibitor http://purl.obolibrary.org/obo/CHEBI_75381 EC 1.11.1.* (peroxidases) inhibitor hydrogen-peroxide:hydrogen-peroxide oxidoreductase inhibitors http://purl.obolibrary.org/obo/CHEBI_76798 EC 1.14.15.4 (steroid 11beta-monooxygenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76843 EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced Fe-S protein as one donor, incorporating 1 O atom) inhibitor steroid 11beta-monooxygenase (EC 1.14.15.4) inhibitors http://purl.obolibrary.org/obo/CHEBI_77654 EC 1.1.1.267 (1-deoxy-D-xylulose-5-phosphate reductoisomerase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76835 EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors http://purl.obolibrary.org/obo/CHEBI_78024 EC 4.1.1.50 (adenosylmethionine decarboxylase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76906 EC 4.1.1.* (carboxy-lyase) inhibitor S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium-salt-forming] inhibitor http://purl.obolibrary.org/obo/CHEBI_78366 EC 2.7.1.1 (hexokinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76881 EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor hexokinase type IV inhibitors http://purl.obolibrary.org/obo/CHEBI_78377 EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor http://purl.obolibrary.org/obo/CHEBI_76857 EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitors http://purl.obolibrary.org/obo/CHEBI_78547 protein kinase A agonist http://purl.obolibrary.org/obo/CHEBI_64106 protein kinase agonist protein kinase A agonists http://purl.obolibrary.org/obo/CHEBI_78548 adenylate cyclase agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist adenylyl cyclase agonists http://purl.obolibrary.org/obo/CHEBI_78681 tropomyosin-related kinase B receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist tropomyosin-related kinase B receptor antagonists http://purl.obolibrary.org/obo/CHEBI_78756 EC 2.5.1.6 (methionine adenosyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76663 EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor EC 2.5.1.6 (methionine adenosyltransferase) inhibitors http://purl.obolibrary.org/obo/CHEBI_85049 EC 1.10.3.1 (catechol oxidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_85048 EC 1.10.3.* (oxidoreductase acting on diphenols and related substances as donors with oxygen as acceptor) inhibitor pyrocatechol oxidase inhibitors http://purl.obolibrary.org/obo/CHEBI_85050 EC 1.10.3.2 (laccase) inhibitor http://purl.obolibrary.org/obo/CHEBI_85048 EC 1.10.3.* (oxidoreductase acting on diphenols and related substances as donors with oxygen as acceptor) inhibitor urushiol oxidase inhibitors http://purl.obolibrary.org/obo/CHEBI_85051 EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76837 EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor quercetin:oxygen 2,3-oxidoreductase (ring-opening) inhibitors http://purl.obolibrary.org/obo/CHEBI_85052 EC 1.4.3.3 (D-amino-acid oxidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76861 EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor D-amino-acid:oxygen oxidoreductase (deaminating) inhibitors http://purl.obolibrary.org/obo/CHEBI_86029 liver X receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist liver X receptor agonists http://purl.obolibrary.org/obo/CHEBI_88048 cyanotoxin http://purl.obolibrary.org/obo/CHEBI_76969 bacterial metabolite cyanotoxins http://purl.obolibrary.org/obo/CHEBI_59105 EC 6.3.2.* (acid--D-amino-acid ligase) inhibitor http://purl.obolibrary.org/obo/CHEBI_75600 EC 6.3.* (C-N bond-forming ligase) inhibitor EC 6.3.2.* [acid--D-amino-acid ligase (peptide synthase)] inhibitors http://purl.obolibrary.org/obo/CHEBI_59499 EC 3.4.13.* (dipeptidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_60258 EC 3.4.* (hydrolases acting on peptide bond) inhibitor EC 3.4.13.* inhibitors http://purl.obolibrary.org/obo/CHEBI_59752 bolaamphiphile http://purl.obolibrary.org/obo/CHEBI_35195 surfactant bolaphile http://purl.obolibrary.org/obo/CHEBI_59864 depigmentation drug http://purl.obolibrary.org/obo/CHEBI_23888 drug depigmentors http://purl.obolibrary.org/obo/CHEBI_59886 HIV fusion inhibitor http://purl.obolibrary.org/obo/CHEBI_64946 anti-HIV agent HIV fusion inhibitors http://purl.obolibrary.org/obo/CHEBI_60218 mimotope http://purl.obolibrary.org/obo/CHEBI_24432 biological role mimotope role http://purl.obolibrary.org/obo/CHEBI_60601 delta-opioid agent http://purl.obolibrary.org/obo/CHEBI_60598 opioid agent delta-opioid agents http://purl.obolibrary.org/obo/CHEBI_60603 kappa-opioid agent http://purl.obolibrary.org/obo/CHEBI_60598 opioid agent kappa-opioid agents http://purl.obolibrary.org/obo/CHEBI_71942 EC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitor http://purl.obolibrary.org/obo/CHEBI_50218 EC 3.1.4.* (phosphoric diester hydrolase) inhibitor cyclic guanosine 3',5'-monophosphate phosphodiesterase inhibitors http://purl.obolibrary.org/obo/CHEBI_72316 virulence factor http://purl.obolibrary.org/obo/CHEBI_27026 toxin virulence factors http://purl.obolibrary.org/obo/CHEBI_75600 EC 6.3.* (C-N bond-forming ligase) inhibitor http://purl.obolibrary.org/obo/CHEBI_75603 EC 6.* (ligase) inhibitor EC 6.3.*.* inhibitors http://purl.obolibrary.org/obo/CHEBI_76759 EC 3.* (hydrolase) inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor hydrolase inhibitors http://purl.obolibrary.org/obo/CHEBI_76841 EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76741 EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor (EC 1.14.13.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_76845 EC 1.14.18.* (oxidoreductase acting on paired donors, miscellaneous compound as one donor, incorporating 1 atom of oxygen) inhibitor http://purl.obolibrary.org/obo/CHEBI_76741 EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor oxidoreductase acting on paired donors, miscellaneous compound as one donor, incorporating 1 atom of oxygen (EC 1.14.18.*) inhibitor http://purl.obolibrary.org/obo/CHEBI_76878 EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor http://purl.obolibrary.org/obo/CHEBI_76661 EC 2.3.* (acyltransferase) inhibitor EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitors http://purl.obolibrary.org/obo/CHEBI_76906 EC 4.1.1.* (carboxy-lyase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76711 EC 4.1.* (C-C lyase) inhibitor carboxy-lyases (EC 4.1.1.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_68481 mTOR inhibitor http://purl.obolibrary.org/obo/CHEBI_37699 protein kinase inhibitor mammalian target of rapamycin inhibitors http://purl.obolibrary.org/obo/CHEBI_68509 glutathione depleting agent http://purl.obolibrary.org/obo/CHEBI_24432 biological role glutathione depletors http://purl.obolibrary.org/obo/CHEBI_68553 guanylate cyclase 2C agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist guanylate cyclase 2C agonists http://purl.obolibrary.org/obo/CHEBI_68557 bradykinin receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist bradykinin receptor antagonists http://purl.obolibrary.org/obo/CHEBI_68581 EC 3.4.21.6 (coagulation factor Xa) inhibitor http://purl.obolibrary.org/obo/CHEBI_5924 EC 3.4.21.* (serine endopeptidase) inhibitor thromboplastin inhibitors http://purl.obolibrary.org/obo/CHEBI_68640 EC 1.14.99.9 (steroid 17alpha-monooxygenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76840 EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor cytochrome P450 17-alpha-hydroxylase/C17,20-lyase inhibitor http://purl.obolibrary.org/obo/CHEBI_75282 ergosterol biosynthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_83317 sterol biosynthesis inhibitor ergosterol biosynthesis inhibitors http://purl.obolibrary.org/obo/CHEBI_76788 EC 3.4.14.* (dipeptidyl- and tripeptidyl-peptidases) inhibitor http://purl.obolibrary.org/obo/CHEBI_60258 EC 3.4.* (hydrolases acting on peptide bond) inhibitor EC 3.4.14.* (dipeptidyl- and tripeptidyl-peptidases) inhibitors http://purl.obolibrary.org/obo/CHEBI_76858 EC 1.3.98.* (oxidoreductase acting on donor CH-CH group, with other, known, acceptors) inhibitor http://purl.obolibrary.org/obo/CHEBI_76729 EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor oxidoreductase acting on CH-CH group of donors, with other, known, acceptors (EC 1.3.98.*) inhibitor http://purl.obolibrary.org/obo/CHEBI_76973 Streptococcus pneumoniae metabolite http://purl.obolibrary.org/obo/CHEBI_76969 bacterial metabolite Streptococcus pneumoniae secondary metabolites http://purl.obolibrary.org/obo/CHEBI_77758 EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor http://purl.obolibrary.org/obo/CHEBI_50218 EC 3.1.4.* (phosphoric diester hydrolase) inhibitor 3',5'-cyclic-AMP phosphodiesterase (EC 3.1.4.53) inhibitor http://purl.obolibrary.org/obo/CHEBI_78678 EC 4.6.1.2 (guanylate cyclase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76716 EC 4.6.* (P-O lyase) inhibitor GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) inhibitors http://purl.obolibrary.org/obo/CHEBI_82891 glucocorticoid receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist glucocorticoid receptor antagonists http://purl.obolibrary.org/obo/CHEBI_84036 EC 3.4.24.24 (gelatinase A) inhibitor http://purl.obolibrary.org/obo/CHEBI_59107 EC 3.4.24.* (metalloendopeptidase) inhibitor type IV collagenase/gelatinase inhibitors http://purl.obolibrary.org/obo/CHEBI_91079 purinergic receptor P2 antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist purinergic receptor P2 antagonists http://purl.obolibrary.org/obo/CHEBI_77088 EC 1.4.7.* (oxidoreductase acting on donor CH-NH2 group, Fe-S protein as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76730 EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor oxidoreductase acting on donor CH-NH2 group, Fe-S protein as acceptor (EC 1.4.7.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_77102 EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76729 EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor inhibitors of oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor http://purl.obolibrary.org/obo/CHEBI_77105 EC 1.10.2.* (oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76737 EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor inhibitors of an oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor (EC 1.10.2.*) http://purl.obolibrary.org/obo/CHEBI_77109 EC 1.21.3.* (oxidoreductase acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76748 EC 1.21.* (oxidoreductase acting on X-H and Y-H to form an X-Y bond) inhibitor EC 1.21.3.* (oxidoreductase acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor) inhibitors http://purl.obolibrary.org/obo/CHEBI_77117 EC 3.5.5.* (hydrolase acting on C-N bonds in nitriles) inhibitor http://purl.obolibrary.org/obo/CHEBI_76764 EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor inhibitors of hydrolases acting on C-N bonds in nitriles http://purl.obolibrary.org/obo/CHEBI_77318 pregnane X receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist pregnane X receptor agonists http://purl.obolibrary.org/obo/CHEBI_77324 UDP-glucuronosyltransferase activator http://purl.obolibrary.org/obo/CHEBI_35224 effector UDP-glucuronosyltransferase activators http://purl.obolibrary.org/obo/CHEBI_77521 thermal degradation product http://purl.obolibrary.org/obo/CHEBI_51086 chemical role thermal degradation products http://purl.obolibrary.org/obo/CHEBI_77705 EC 3.4.19.* (omega-peptidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_60258 EC 3.4.* (hydrolases acting on peptide bond) inhibitor omega-peptidase inhibitors http://purl.obolibrary.org/obo/CHEBI_77731 p53 activator http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role tumour suppressor p53 activators http://purl.obolibrary.org/obo/CHEBI_77750 ATP/ADP translocase inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role ATP/ADP translocase inhibitors http://purl.obolibrary.org/obo/CHEBI_77763 EC 1.2.1.88 (L-glutamate gamma-semialdehyde dehydrogenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76852 EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) inhibitors http://purl.obolibrary.org/obo/CHEBI_77783 EC 1.14.13.67 (quinine 3-monooxygenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76841 EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor quinine,NADPH:oxygen oxidoreductase inhibitors http://purl.obolibrary.org/obo/CHEBI_77953 EC 6.1.1.4 (leucine--tRNA ligase) inhibitor http://purl.obolibrary.org/obo/CHEBI_75416 EC 6.1.1.* (ligases forming aminoacyl tRNA and related compounds) inhibitor leucyl-transfer ribonucleic acid synthetase inhibitors http://purl.obolibrary.org/obo/CHEBI_77963 sequestrant http://purl.obolibrary.org/obo/CHEBI_65255 food preservative sequestrants http://purl.obolibrary.org/obo/CHEBI_77964 anticaking agent http://purl.obolibrary.org/obo/CHEBI_33232 application anticaking agents http://purl.obolibrary.org/obo/CHEBI_77968 humectant http://purl.obolibrary.org/obo/CHEBI_33232 application humectants http://purl.obolibrary.org/obo/CHEBI_77972 food glazing agent http://purl.obolibrary.org/obo/CHEBI_64047 food additive glazing agents http://purl.obolibrary.org/obo/CHEBI_77973 antifoaming agent http://purl.obolibrary.org/obo/CHEBI_33232 application defoamers http://purl.obolibrary.org/obo/CHEBI_78006 food colour retention agent http://purl.obolibrary.org/obo/CHEBI_64047 food additive food colour retention agents http://purl.obolibrary.org/obo/CHEBI_78007 foaming agent http://purl.obolibrary.org/obo/CHEBI_64047 food additive foaming agents http://purl.obolibrary.org/obo/CHEBI_78009 Wiskott-Aldrich syndrome protein inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role Wiskott-Aldrich syndrome protein inhibitors http://purl.obolibrary.org/obo/CHEBI_78059 food additive carrier http://purl.obolibrary.org/obo/CHEBI_64047 food additive food additive carriers http://purl.obolibrary.org/obo/CHEBI_78152 enzyme mimic http://purl.obolibrary.org/obo/CHEBI_33232 application enzyme mimics http://purl.obolibrary.org/obo/CHEBI_78248 vitamin B1 antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist vitamin B1 antagonists http://purl.obolibrary.org/obo/CHEBI_78372 EC 3.1.1.5 (lysophospholipase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76773 EC 3.1.1.* (carboxylic ester hydrolase) inhibitor phospholipase B inhibitors http://purl.obolibrary.org/obo/CHEBI_78380 EC 3.5.4.1 (cytosine deaminase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76809 EC 3.5.4.* (non-peptide cyclic amidine C-N hydrolase) inhibitor isocytosine deaminase inhibitors http://purl.obolibrary.org/obo/CHEBI_78381 EC 5.1.2.* (racemases acting on hydroxy acids and derivatives) inhibitor http://purl.obolibrary.org/obo/CHEBI_76692 EC 5.1.* (racemase/epimerase) inhibitor inhibitors of racemases acting on hydroxy acids and derivatives http://purl.obolibrary.org/obo/CHEBI_78382 EC 5.1.3.* (racemases acting on carbohydrates and derivatives) inhibitor http://purl.obolibrary.org/obo/CHEBI_76692 EC 5.1.* (racemase/epimerase) inhibitor EC 5.1.3.* (racemases acting on carbohydrates and derivatives) inhibitors http://purl.obolibrary.org/obo/CHEBI_78383 EC 5.1.99.* (racemases acting on other compounds) inhibitor http://purl.obolibrary.org/obo/CHEBI_76692 EC 5.1.* (racemase/epimerase) inhibitor inhibitor of racemases acting on other compounds (EC 5.1.99.*) http://purl.obolibrary.org/obo/CHEBI_78384 EC 5.1.3.2 (UDP-glucose 4-epimerase) inhibitor http://purl.obolibrary.org/obo/CHEBI_78382 EC 5.1.3.* (racemases acting on carbohydrates and derivatives) inhibitor uridine diphosphate galactose 4-epimerase inhibitors http://purl.obolibrary.org/obo/CHEBI_78622 EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} inhibitor http://purl.obolibrary.org/obo/CHEBI_76812 EC 2.7.11.* (protein-serine/threonine kinase) inhibitor hydroxymethylglutaryl-CoA reductase kinase inhibitors http://purl.obolibrary.org/obo/CHEBI_78623 bone morphogenetic protein receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist bone morphogenetic protein receptor inhibitors http://purl.obolibrary.org/obo/CHEBI_78728 EC 1.3.1.72 (Delta(24)-sterol reductase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76857 EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor Delta(24)-sterol reductase (EC 1.3.1.72) inhibitors http://purl.obolibrary.org/obo/CHEBI_78760 EC 2.7.1.91 (sphinganine kinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76881 EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor dihydrosphingosine kinase (phosphorylating) inhibitors http://purl.obolibrary.org/obo/CHEBI_78926 survivin dimerisation modulator http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role survivin modulators http://purl.obolibrary.org/obo/CHEBI_78928 EC 3.6.1.3 (adenosinetriphosphatase) inhibitor http://purl.obolibrary.org/obo/CHEBI_78927 EC 3.6.1.* (hydrolases acting on acid anhydrides in P-containing anhydrides) inhibitor complex V (mitochondrial electron transport) inhibitor http://purl.obolibrary.org/obo/CHEBI_83734 sterol demethylation inhibitor http://purl.obolibrary.org/obo/CHEBI_35718 antifungal agent sterol demethylation inhibitors http://purl.obolibrary.org/obo/CHEBI_87588 Smad3 inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor mothers against decapentaplegic homolog 3 inhibitor http://purl.obolibrary.org/obo/CHEBI_87786 signal transducer and activator of transcription 5 protein inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role signal transducer and activator of transcription 5 protein inhibitors http://purl.obolibrary.org/obo/CHEBI_88285 EC 2.7.12.* [dual-specificity kinases (those acting on Ser/Thr and Tyr residues)] inhibitor http://purl.obolibrary.org/obo/CHEBI_76668 EC 2.7.* (P-containing group transferase) inhibitor inhibitor of dual-specificity kinases (those acting on Ser/Thr and Tyr residues) (EC 2.7.12.*) http://purl.obolibrary.org/obo/CHEBI_88286 EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_88285 EC 2.7.12.* [dual-specificity kinases (those acting on Ser/Thr and Tyr residues)] inhibitor ATP:protein phosphotransferase (MAPKKK-activated) inhibitors http://purl.obolibrary.org/obo/CHEBI_88295 G-protein-coupled receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist GPCR antagonists http://purl.obolibrary.org/obo/CHEBI_88336 retinoic acid receptor gamma agonist http://purl.obolibrary.org/obo/CHEBI_67198 retinoic acid receptor agonist nuclear receptor subfamily 1, group B, member 3 agonist http://purl.obolibrary.org/obo/CHEBI_88355 alpha-secretase activator http://purl.obolibrary.org/obo/CHEBI_35224 effector alpha-secretase activators http://purl.obolibrary.org/obo/CHEBI_90113 EC 1.1.1.170 [3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating)] inhibitor http://purl.obolibrary.org/obo/CHEBI_76835 EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor 3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating) inhibitor http://purl.obolibrary.org/obo/NCBITaxon_10090 Mus musculus http://www.bioassayontology.org/bao#BAO_0000362 mammalian mouse http://purl.obolibrary.org/obo/NCBITaxon_10116 Rattus norvegicus http://www.bioassayontology.org/bao#BAO_0000362 mammalian rats http://purl.obolibrary.org/obo/NCBITaxon_10376 Human gammaherpesvirus 4 http://www.bioassayontology.org/bao#BAO_0000232 virus Human herpesvirus type 4 http://purl.obolibrary.org/obo/NCBITaxon_11250 Human orthopneumovirus http://www.bioassayontology.org/bao#BAO_0000232 virus human RSV http://purl.obolibrary.org/obo/NCBITaxon_1280 Staphylococcus aureus http://www.bioassayontology.org/bao#BAO_0000364 bacterium Staphylococcus pyogenes aureus http://purl.obolibrary.org/obo/NCBITaxon_1392 Bacillus anthracis http://www.bioassayontology.org/bao#BAO_0000364 bacterium anthrax bacterium http://purl.obolibrary.org/obo/NCBITaxon_5833 Plasmodium falciparum http://www.bioassayontology.org/bao#BAO_0000662 protozoan malaria parasite P. falciparum http://purl.obolibrary.org/obo/NCBITaxon_5665 Leishmania mexicana http://www.bioassayontology.org/bao#BAO_0000662 protozoan Leishmania (Leishmania) mexicana http://purl.obolibrary.org/obo/CHEBI_101090 EC 5.4.99.* (intramolecular transferase transferring other groups) inhibitor http://purl.obolibrary.org/obo/CHEBI_76695 EC 5.4.* (intramolecular transferase) inhibitor intramolecular transferase transferring other groups inhibitor http://purl.obolibrary.org/obo/CHEBI_102248 EC 1.14.11.29 (hypoxia-inducible factor-proline dioxygenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76902 EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor hypoxia-inducible factor-L-proline, 2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) inhibitors http://purl.obolibrary.org/obo/CHEBI_102368 EC 2.6.1.40 [(R)-3-amino-2-methylpropionate--pyruvate transaminase] inhibitor http://purl.obolibrary.org/obo/CHEBI_76879 EC 2.6.1.* (transaminase) inhibitor D-beta-aminoisobutyrate:pyruvate aminotransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_131604 Mycoplasma genitalium metabolite http://purl.obolibrary.org/obo/CHEBI_76969 bacterial metabolite Mycoplasma genitalium metabolites http://purl.obolibrary.org/obo/CHEBI_131787 dopamine receptor D2 antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist D2R antagonist http://purl.obolibrary.org/obo/CHEBI_22586 antioxidant http://purl.obolibrary.org/obo/CHEBI_51086 chemical role antoxidant http://purl.obolibrary.org/obo/CHEBI_22587 antiviral agent http://purl.obolibrary.org/obo/CHEBI_33281 antimicrobial agent antivirals http://purl.obolibrary.org/obo/CHEBI_23018 EC 4.2.1.1 (carbonic anhydrase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76907 EC 4.2.1.* (hydro-lyases) inhibitor carbonate hydro-lyase (carbon-dioxide-forming) inhibitor http://purl.obolibrary.org/obo/CHEBI_25212 metabolite http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role secondary metabolites http://purl.obolibrary.org/obo/CHEBI_33229 vitamin http://purl.obolibrary.org/obo/CHEBI_78295 food component vitaminum http://purl.obolibrary.org/obo/CHEBI_33281 antimicrobial agent http://purl.obolibrary.org/obo/CHEBI_24432 biological role microbicides http://purl.obolibrary.org/obo/CHEBI_33282 antibacterial agent http://purl.obolibrary.org/obo/CHEBI_33281 antimicrobial agent bactericides http://purl.obolibrary.org/obo/CHEBI_33288 rodenticide http://purl.obolibrary.org/obo/CHEBI_25944 pesticide rodenticides http://purl.obolibrary.org/obo/CHEBI_35221 antimetabolite http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role antimetabolites http://purl.obolibrary.org/obo/CHEBI_35441 antiinfective agent http://purl.obolibrary.org/obo/CHEBI_23888 drug antiinfective drug http://purl.obolibrary.org/obo/CHEBI_35470 central nervous system drug http://purl.obolibrary.org/obo/CHEBI_23888 drug central nervous system agents http://purl.obolibrary.org/obo/CHEBI_35471 psychotropic drug http://purl.obolibrary.org/obo/CHEBI_35470 central nervous system drug psychotropic drugs http://purl.obolibrary.org/obo/CHEBI_35472 anti-inflammatory drug http://purl.obolibrary.org/obo/CHEBI_23888 drug antiinflammatory drugs http://purl.obolibrary.org/obo/CHEBI_35474 anxiolytic drug http://purl.obolibrary.org/obo/CHEBI_35473 tranquilizing drug minor tranquilizing agents http://purl.obolibrary.org/obo/CHEBI_35475 non-steroidal anti-inflammatory drug http://purl.obolibrary.org/obo/CHEBI_35842 antirheumatic drug non-steroidal anti-inflammatory drugs http://purl.obolibrary.org/obo/CHEBI_35476 antipsychotic agent http://purl.obolibrary.org/obo/CHEBI_35473 tranquilizing drug neuroleptiques http://purl.obolibrary.org/obo/CHEBI_35488 central nervous system depressant http://purl.obolibrary.org/obo/CHEBI_35470 central nervous system drug central nervous system depressants http://purl.obolibrary.org/obo/CHEBI_35498 diuretic http://purl.obolibrary.org/obo/CHEBI_23888 drug diuretics http://purl.obolibrary.org/obo/CHEBI_35610 antineoplastic agent http://purl.obolibrary.org/obo/CHEBI_23888 drug cytostatic http://purl.obolibrary.org/obo/CHEBI_35620 vasodilator agent http://purl.obolibrary.org/obo/CHEBI_35554 cardiovascular drug vasodilator agents http://purl.obolibrary.org/obo/CHEBI_35623 anticonvulsant http://purl.obolibrary.org/obo/CHEBI_35488 central nervous system depressant antiepileptiques http://purl.obolibrary.org/obo/CHEBI_35674 antihypertensive agent http://purl.obolibrary.org/obo/CHEBI_35554 cardiovascular drug antihypertensive drugs http://purl.obolibrary.org/obo/CHEBI_35703 xenobiotic http://purl.obolibrary.org/obo/CHEBI_24432 biological role xenobiotics http://purl.obolibrary.org/obo/CHEBI_35717 sedative http://purl.obolibrary.org/obo/CHEBI_35488 central nervous system depressant sedatives and hypnotics http://purl.obolibrary.org/obo/CHEBI_35718 antifungal agent http://purl.obolibrary.org/obo/CHEBI_33281 antimicrobial agent antifungals http://purl.obolibrary.org/obo/CHEBI_35941 serotonergic agonist http://purl.obolibrary.org/obo/CHEBI_48278 serotonergic drug serotonin agonists http://purl.obolibrary.org/obo/CHEBI_36044 antiviral drug http://purl.obolibrary.org/obo/CHEBI_36043 antimicrobial drug antiviral drugs http://purl.obolibrary.org/obo/CHEBI_36047 antibacterial drug http://purl.obolibrary.org/obo/CHEBI_36043 antimicrobial drug antibacterial drugs http://purl.obolibrary.org/obo/CHEBI_37890 alpha-adrenergic antagonist http://purl.obolibrary.org/obo/CHEBI_48539 alpha-adrenergic drug alpha-adrenoceptor antagonists http://purl.obolibrary.org/obo/CHEBI_37956 histamine antagonist http://purl.obolibrary.org/obo/CHEBI_37957 histaminergic drug histamine receptor blockers http://purl.obolibrary.org/obo/CHEBI_38157 iron chelator http://purl.obolibrary.org/obo/CHEBI_38161 chelator iron chelators http://purl.obolibrary.org/obo/CHEBI_38215 calcium channel blocker http://purl.obolibrary.org/obo/CHEBI_38808 calcium channel modulator calcium channel blockers http://purl.obolibrary.org/obo/CHEBI_38325 muscarinic agonist http://purl.obolibrary.org/obo/CHEBI_38324 cholinergic agonist muscarinic cholinergic agonists http://purl.obolibrary.org/obo/CHEBI_38877 intravenous anaesthetic http://purl.obolibrary.org/obo/CHEBI_38869 general anaesthetic intravenous anesthetics http://purl.obolibrary.org/obo/CHEBI_39456 antiglaucoma drug http://purl.obolibrary.org/obo/CHEBI_66981 ophthalmology drug antiglaucoma drugs http://purl.obolibrary.org/obo/CHEBI_48279 serotonergic antagonist http://purl.obolibrary.org/obo/CHEBI_48278 serotonergic drug serotonin blockaders http://purl.obolibrary.org/obo/CHEBI_48422 angiogenesis inhibitor http://purl.obolibrary.org/obo/CHEBI_23888 drug anti-angiogenic agent http://purl.obolibrary.org/obo/CHEBI_48550 EC 1.1.1.21 (aldehyde reductase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76835 EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor polyol dehydrogenase (NADP(+)) inhibitors http://purl.obolibrary.org/obo/CHEBI_48561 dopaminergic antagonist http://purl.obolibrary.org/obo/CHEBI_48560 dopaminergic agent dopaminergic antagonists http://purl.obolibrary.org/obo/CHEBI_48876 muscarinic antagonist http://purl.obolibrary.org/obo/CHEBI_48873 cholinergic antagonist muscarinic antagonists http://purl.obolibrary.org/obo/CHEBI_49103 drug metabolite http://purl.obolibrary.org/obo/CHEBI_76967 human xenobiotic metabolite drug metabolites http://purl.obolibrary.org/obo/CHEBI_49159 leukotriene antagonist http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist leukotriene receptor antagonists http://purl.obolibrary.org/obo/CHEBI_49167 anti-asthmatic drug http://purl.obolibrary.org/obo/CHEBI_65023 anti-asthmatic agent anti-asthmatic drugs http://purl.obolibrary.org/obo/CHEBI_50176 keratolytic drug http://purl.obolibrary.org/obo/CHEBI_50177 dermatologic drug skin-peeling agent http://purl.obolibrary.org/obo/CHEBI_50183 P450 inhibitor http://purl.obolibrary.org/obo/CHEBI_76898 EC 1.14.14.1 (unspecific monooxygenase) inhibitor cytochrome P450 inhibitors http://purl.obolibrary.org/obo/CHEBI_50249 anticoagulant http://purl.obolibrary.org/obo/CHEBI_50248 hematologic agent anticoagulants http://purl.obolibrary.org/obo/CHEBI_50267 protective agent http://purl.obolibrary.org/obo/CHEBI_23888 drug protective agents http://purl.obolibrary.org/obo/CHEBI_50390 EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor http://purl.obolibrary.org/obo/CHEBI_76866 EC 1.6.5.* (oxidoreductase acting on NADH or NADPH with a quinone or similar as acceptor) inhibitor NAD(P)H:(quinone-acceptor)oxidoreductase inhibitors http://purl.obolibrary.org/obo/CHEBI_50502 EC 2.5.1.15 (dihydropteroate synthase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76663 EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_50629 cyclooxygenase 2 inhibitor http://purl.obolibrary.org/obo/CHEBI_35544 EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor prostaglandin-endoperoxide synthase 2 inhibitors http://purl.obolibrary.org/obo/CHEBI_50750 EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor http://purl.obolibrary.org/obo/CHEBI_70727 topoisomerase inhibitor EC 5.99.1.3 (DNA topoisomerase (ATP-hydrolysing)) inhibitor http://purl.obolibrary.org/obo/CHEBI_50903 carcinogenic agent http://purl.obolibrary.org/obo/CHEBI_52209 aetiopathogenetic role carcinogens http://purl.obolibrary.org/obo/CHEBI_50925 EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76812 EC 2.7.11.* (protein-serine/threonine kinase) inhibitor non-specific serine/threonine protein kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_52214 ligand http://purl.obolibrary.org/obo/CHEBI_51086 chemical role ligands http://purl.obolibrary.org/obo/CHEBI_53559 topoisomerase IV inhibitor http://purl.obolibrary.org/obo/CHEBI_70727 topoisomerase inhibitor topoisomerase IV inhibitors http://purl.obolibrary.org/obo/CHEBI_53756 HIV-1 reverse transcriptase inhibitor http://purl.obolibrary.org/obo/CHEBI_52629 EC 3.1.26.13 (retroviral ribonuclease H) inhibitor reverse transcriptase inhibitors http://purl.obolibrary.org/obo/CHEBI_55347 vitamin K antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist vitamin K antagonists http://purl.obolibrary.org/obo/CHEBI_59107 EC 3.4.24.* (metalloendopeptidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_60258 EC 3.4.* (hydrolases acting on peptide bond) inhibitor metalloendopeptidase inhibitors http://purl.obolibrary.org/obo/CHEBI_59517 DNA synthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_76932 pathway inhibitor DNA synthesis inhibitors http://purl.obolibrary.org/obo/CHEBI_61908 EC 1.14.13.39 (nitric oxide synthase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76841 EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor endothelium-derived relaxing factor synthase inhibitor http://purl.obolibrary.org/obo/CHEBI_61966 metabotropic glutamate receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist metabotropic glutamate receptor agonists http://purl.obolibrary.org/obo/CHEBI_62868 hepatoprotective agent http://purl.obolibrary.org/obo/CHEBI_50267 protective agent hepatoprotective agents http://purl.obolibrary.org/obo/CHEBI_63726 neuroprotective agent http://purl.obolibrary.org/obo/CHEBI_50267 protective agent neuroprotective agents http://purl.obolibrary.org/obo/CHEBI_64932 cathepsin B inhibitor http://purl.obolibrary.org/obo/CHEBI_64152 cysteine protease inhibitor cathepsin II inhibitors http://purl.obolibrary.org/obo/CHEBI_64964 EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76837 EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor arachidonate 5-lipoxygenase (EC 1.13.11.34) inhibitors http://purl.obolibrary.org/obo/CHEBI_65023 anti-asthmatic agent http://purl.obolibrary.org/obo/CHEBI_33232 application antiasthmatic agents http://purl.obolibrary.org/obo/CHEBI_66981 ophthalmology drug http://purl.obolibrary.org/obo/CHEBI_23888 drug ophthalmology drugs http://purl.obolibrary.org/obo/CHEBI_67267 EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitor http://purl.obolibrary.org/obo/CHEBI_76663 EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitors http://purl.obolibrary.org/obo/CHEBI_68495 apoptosis inducer http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role apoptosis inducers http://purl.obolibrary.org/obo/CHEBI_72483 vesicular glutamate transport inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role vesicular glutamate transporter 1 inhibitors http://purl.obolibrary.org/obo/CHEBI_74925 EC 3.4.23.46 (memapsin 2) inhibitor http://purl.obolibrary.org/obo/CHEBI_76885 EC 3.4.23.* (aspartic endopeptidase) inhibitor beta-site Alzheimer's amyloid precursor protein cleaving enzyme 1 inhibitors http://purl.obolibrary.org/obo/CHEBI_75767 animal metabolite http://purl.obolibrary.org/obo/CHEBI_75763 eukaryotic metabolite animal metabolites http://purl.obolibrary.org/obo/CHEBI_75771 mouse metabolite http://purl.obolibrary.org/obo/CHEBI_75768 mammalian metabolite mouse metabolites http://purl.obolibrary.org/obo/CHEBI_76695 EC 5.4.* (intramolecular transferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_75596 EC 5.* (isomerase) inhibitor intramolecular transferase inhibitors http://purl.obolibrary.org/obo/CHEBI_76879 EC 2.6.1.* (transaminase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76665 EC 2.6.* (nitrogenous group transferase) inhibitor transaminase (EC 2.6.1.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_76902 EC 1.14.11.* (oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors) inhibitor http://purl.obolibrary.org/obo/CHEBI_76741 EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor oxidoreductase acting on paired donors, 2-oxoglutarate as one donor, incorporating 1 atom each of oxygen into both donors (EC 1.14.11.*) inhibitor http://purl.obolibrary.org/obo/CHEBI_76924 plant metabolite http://purl.obolibrary.org/obo/CHEBI_75763 eukaryotic metabolite plant secondary metabolites http://purl.obolibrary.org/obo/CHEBI_76946 fungal metabolite http://purl.obolibrary.org/obo/CHEBI_75763 eukaryotic metabolite fungal metabolites http://purl.obolibrary.org/obo/CHEBI_76971 Escherichia coli metabolite http://purl.obolibrary.org/obo/CHEBI_76969 bacterial metabolite Escherichia coli metabolites http://purl.obolibrary.org/obo/CHEBI_76990 mycoestrogen http://purl.obolibrary.org/obo/CHEBI_50114 estrogen mycoestrogens http://purl.obolibrary.org/obo/CHEBI_78298 environmental contaminant http://purl.obolibrary.org/obo/CHEBI_51086 chemical role environmental contaminants http://purl.obolibrary.org/obo/CHEBI_88188 drug allergen http://purl.obolibrary.org/obo/CHEBI_23888 drug allergenic drug http://purl.obolibrary.org/obo/CHEBI_91202 TGFbeta receptor antagonist http://purl.obolibrary.org/obo/CHEBI_137123 EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor transforming growth factor receptor antagonists http://purl.obolibrary.org/obo/CHEBI_21241 vitamin C http://purl.obolibrary.org/obo/CHEBI_85046 skin lightening agent vitaminum C http://purl.obolibrary.org/obo/CHEBI_23354 coenzyme http://purl.obolibrary.org/obo/CHEBI_23357 cofactor coenzymes http://purl.obolibrary.org/obo/CHEBI_27314 water-soluble vitamin http://purl.obolibrary.org/obo/CHEBI_33229 vitamin water-soluble vitamins http://purl.obolibrary.org/obo/CHEBI_50185 fatty acid synthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_76932 pathway inhibitor fatty acid synthesis inhibitors http://purl.obolibrary.org/obo/CHEBI_63247 reducing agent http://purl.obolibrary.org/obo/CHEBI_51086 chemical role reductants http://purl.obolibrary.org/obo/CHEBI_64577 flour treatment agent http://purl.obolibrary.org/obo/CHEBI_64047 food additive improving agents http://purl.obolibrary.org/obo/CHEBI_64996 EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76837 EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor arachidonate 15-lipoxygenase (EC 1.13.11.33) inhibitor http://purl.obolibrary.org/obo/CHEBI_65001 EC 3.1.1.3 (triacylglycerol lipase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76773 EC 3.1.1.* (carboxylic ester hydrolase) inhibitor post-heparin plasma protamine-resistant lipase inhibitors http://purl.obolibrary.org/obo/CHEBI_65256 antimicrobial food preservative http://purl.obolibrary.org/obo/CHEBI_33281 antimicrobial agent antimicrobial preservatives http://purl.obolibrary.org/obo/CHEBI_75763 eukaryotic metabolite http://purl.obolibrary.org/obo/CHEBI_25212 metabolite eukaryotic metabolites http://purl.obolibrary.org/obo/CHEBI_76976 bacterial xenobiotic metabolite http://purl.obolibrary.org/obo/CHEBI_76969 bacterial metabolite bacterial xenobiotic metabolites http://purl.obolibrary.org/obo/CHEBI_77962 food antioxidant http://purl.obolibrary.org/obo/CHEBI_22586 antioxidant food antioxidants http://purl.obolibrary.org/obo/CHEBI_84735 algal metabolite http://purl.obolibrary.org/obo/CHEBI_75763 eukaryotic metabolite algal metabolites http://purl.obolibrary.org/obo/CHEBI_25435 mutagen http://purl.obolibrary.org/obo/CHEBI_50902 genotoxin mutagens http://purl.obolibrary.org/obo/CHEBI_35442 antiparasitic agent http://purl.obolibrary.org/obo/CHEBI_35441 antiinfective agent parasiticides http://purl.obolibrary.org/obo/CHEBI_50790 EC 1.14.14.14 (aromatase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76838 EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor oestrogen synthetase inhibitors http://purl.obolibrary.org/obo/CHEBI_53000 epitope http://purl.obolibrary.org/obo/CHEBI_24432 biological role epitope role http://purl.obolibrary.org/obo/CHEBI_24020 fat-soluble vitamin http://purl.obolibrary.org/obo/CHEBI_33229 vitamin fettloesliche Vitamine http://purl.obolibrary.org/obo/CHEBI_35523 bronchodilator agent http://purl.obolibrary.org/obo/CHEBI_23888 drug broncholytic agent http://purl.obolibrary.org/obo/CHEBI_35640 adrenergic uptake inhibitor http://purl.obolibrary.org/obo/CHEBI_37962 adrenergic agent norepinephrine reuptake inhibitors http://purl.obolibrary.org/obo/CHEBI_38070 anti-arrhythmia drug http://purl.obolibrary.org/obo/CHEBI_35554 cardiovascular drug antiarrhythmic agent http://purl.obolibrary.org/obo/CHEBI_61115 EC 3.5.1.98 (histone deacetylase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76807 EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor histone deacetylase inhibitors http://purl.obolibrary.org/obo/CHEBI_63330 sodium-dependent Pi-transporter inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor sodium-dependent inorganic phosphate transporter inhibitor http://purl.obolibrary.org/obo/CHEBI_22676 auxin http://purl.obolibrary.org/obo/CHEBI_37848 plant hormone auxins http://purl.obolibrary.org/obo/CHEBI_23240 chromophore http://purl.obolibrary.org/obo/CHEBI_52215 photochemical role chromophores http://purl.obolibrary.org/obo/CHEBI_23366 compatible osmolytes http://purl.obolibrary.org/obo/CHEBI_25728 osmolyte compatible osmolytes http://purl.obolibrary.org/obo/CHEBI_25355 mitochondrial respiratory-chain inhibitor http://purl.obolibrary.org/obo/CHEBI_38497 respiratory-chain inhibitor mitochondrial respiratory chain inhibitors http://purl.obolibrary.org/obo/CHEBI_25747 oxidized luciferins http://purl.obolibrary.org/obo/CHEBI_25078 luciferin oxidized luciferins http://purl.obolibrary.org/obo/CHEBI_26087 photosynthetic electron-transport chain inhibitor http://purl.obolibrary.org/obo/CHEBI_38496 electron-transport chain inhibitor photosynthetic electron transport chain inhibitors http://purl.obolibrary.org/obo/CHEBI_26115 phytoalexin http://purl.obolibrary.org/obo/CHEBI_38231 phytotoxin phytoalexins http://purl.obolibrary.org/obo/CHEBI_26130 biological pigment http://purl.obolibrary.org/obo/CHEBI_52208 biophysical role pigments http://purl.obolibrary.org/obo/CHEBI_33287 fertilizer http://purl.obolibrary.org/obo/CHEBI_33286 agrochemical fertilizers http://purl.obolibrary.org/obo/CHEBI_33295 diagnostic agent http://purl.obolibrary.org/obo/CHEBI_52217 pharmaceutical diagnostic aid http://purl.obolibrary.org/obo/CHEBI_35230 fossil fuel http://purl.obolibrary.org/obo/CHEBI_33292 fuel fossil fuel http://purl.obolibrary.org/obo/CHEBI_35487 EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor http://purl.obolibrary.org/obo/CHEBI_76852 EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitors http://purl.obolibrary.org/obo/CHEBI_35608 EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76775 EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitors http://purl.obolibrary.org/obo/CHEBI_35664 EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76835 EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor hydroxymethylglutaryl-CoA reductase inhibitors http://purl.obolibrary.org/obo/CHEBI_35679 antilipemic drug http://purl.obolibrary.org/obo/CHEBI_23888 drug hypolipidemic agents http://purl.obolibrary.org/obo/CHEBI_35821 anticholesteremic drug http://purl.obolibrary.org/obo/CHEBI_35679 antilipemic drug hypocholesteremic agent http://purl.obolibrary.org/obo/CHEBI_36043 antimicrobial drug http://purl.obolibrary.org/obo/CHEBI_35441 antiinfective agent antimicrobial drugs http://purl.obolibrary.org/obo/CHEBI_37733 EC 3.1.1.8 (cholinesterase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76773 EC 3.1.1.* (carboxylic ester hydrolase) inhibitor pseudocholinesterase inhibitors http://purl.obolibrary.org/obo/CHEBI_37848 plant hormone http://purl.obolibrary.org/obo/CHEBI_24621 hormone plant hormones http://purl.obolibrary.org/obo/CHEBI_37958 dye http://purl.obolibrary.org/obo/CHEBI_33232 application teintures http://purl.obolibrary.org/obo/CHEBI_37962 adrenergic agent http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent adrenergics http://purl.obolibrary.org/obo/CHEBI_38870 inhalation anaesthetic http://purl.obolibrary.org/obo/CHEBI_38869 general anaesthetic inhalation anesthetics http://purl.obolibrary.org/obo/CHEBI_39412 bridged diphenyl acaricide http://purl.obolibrary.org/obo/CHEBI_22153 acaricide bridged diphenyl acaricides http://purl.obolibrary.org/obo/CHEBI_46787 solvent http://purl.obolibrary.org/obo/CHEBI_51086 chemical role solvents http://purl.obolibrary.org/obo/CHEBI_48218 antiseptic drug http://purl.obolibrary.org/obo/CHEBI_35441 antiinfective agent topical microbicides http://purl.obolibrary.org/obo/CHEBI_48219 disinfectant http://purl.obolibrary.org/obo/CHEBI_33281 antimicrobial agent disinfecting agent http://purl.obolibrary.org/obo/CHEBI_48354 polar solvent http://purl.obolibrary.org/obo/CHEBI_46787 solvent polar solvents http://purl.obolibrary.org/obo/CHEBI_48355 non-polar solvent http://purl.obolibrary.org/obo/CHEBI_46787 solvent non-polar solvents http://purl.obolibrary.org/obo/CHEBI_48407 antiparkinson drug http://purl.obolibrary.org/obo/CHEBI_66956 antidyskinesia agent antiparkinson agent http://purl.obolibrary.org/obo/CHEBI_48560 dopaminergic agent http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent dopaminergic agents http://purl.obolibrary.org/obo/CHEBI_49323 contraceptive drug http://purl.obolibrary.org/obo/CHEBI_50689 reproductive control drug contraceptive drugs http://purl.obolibrary.org/obo/CHEBI_50248 hematologic agent http://purl.obolibrary.org/obo/CHEBI_23888 drug hematologic agents http://purl.obolibrary.org/obo/CHEBI_50276 EC 5.99.1.2 (DNA topoisomerase) inhibitor http://purl.obolibrary.org/obo/CHEBI_70727 topoisomerase inhibitor type I DNA topoisomerase inhibitors http://purl.obolibrary.org/obo/CHEBI_50370 parasympatholytic http://purl.obolibrary.org/obo/CHEBI_48873 cholinergic antagonist parasympatholytics http://purl.obolibrary.org/obo/CHEBI_50445 EC 3.5.4.4 (adenosine deaminase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76809 EC 3.5.4.* (non-peptide cyclic amidine C-N hydrolase) inhibitor deoxyadenosine deaminase inhibitors http://purl.obolibrary.org/obo/CHEBI_50469 EC 3.1.1.4 (phospholipase A2) inhibitor http://purl.obolibrary.org/obo/CHEBI_76773 EC 3.1.1.* (carboxylic ester hydrolase) inhibitor phospholipase A2 inhibitors http://purl.obolibrary.org/obo/CHEBI_50505 sweetening agent http://purl.obolibrary.org/obo/CHEBI_35617 flavouring agent sweeteners http://purl.obolibrary.org/obo/CHEBI_50513 mydriatic agent http://purl.obolibrary.org/obo/CHEBI_23888 drug mydriatics http://purl.obolibrary.org/obo/CHEBI_50696 EC 2.4.1.129 (peptidoglycan glycosyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76789 EC 2.4.1.* (hexosyltransferase) inhibitor peptidoglycan glycosyltransferase (EC 2.4.1.129) inhibitor http://purl.obolibrary.org/obo/CHEBI_50847 immunological adjuvant http://purl.obolibrary.org/obo/CHEBI_50846 immunomodulator Immunostimulant http://purl.obolibrary.org/obo/CHEBI_52425 EC 3.2.1.18 (exo-alpha-sialidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_36044 antiviral drug sialidase inhibitors http://purl.obolibrary.org/obo/CHEBI_53746 EC 1.1.1.205 (IMP dehydrogenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76835 EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor inosinic acid dehydrogenase inhibitors http://purl.obolibrary.org/obo/CHEBI_59647 EC 2.3.1.50 (serine C-palmitoyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76878 EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) inhibitor http://purl.obolibrary.org/obo/CHEBI_59826 progestin http://purl.obolibrary.org/obo/CHEBI_50745 progestogen progestins http://purl.obolibrary.org/obo/CHEBI_60606 opioid receptor agonist http://purl.obolibrary.org/obo/CHEBI_60598 opioid agent opioid receptor agonists http://purl.obolibrary.org/obo/CHEBI_60832 tubulin modulator http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role tubulin modulators http://purl.obolibrary.org/obo/CHEBI_61951 microtubule-destabilising agent http://purl.obolibrary.org/obo/CHEBI_60832 tubulin modulator microtubule-destabilizing agents http://purl.obolibrary.org/obo/CHEBI_62089 EC 1.4.7.1 [glutamate synthase (ferredoxin)] inhibitor http://purl.obolibrary.org/obo/CHEBI_76730 EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor glutamate synthase (ferredoxin) (EC 1.4.7.1) inhibitor http://purl.obolibrary.org/obo/CHEBI_62215 allelochemical http://purl.obolibrary.org/obo/CHEBI_25212 metabolite allelochemicals http://purl.obolibrary.org/obo/CHEBI_62871 EC 4.3.1.24 (phenylalanine ammonia-lyase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76832 EC 4.3.1.* (ammonia-lyase) inhibitor L-phenylalanine ammonia-lyase (trans-cinnamate-forming) inhibitor http://purl.obolibrary.org/obo/CHEBI_62913 EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76790 EC 2.4.2.* (pentosyltransferase) inhibitor NAD(+):poly(ADP-D-ribosyl)-acceptor ADP-D-ribosyl-transferase inhibitors http://purl.obolibrary.org/obo/CHEBI_63332 EC 3.1.3.1 (alkaline phosphatase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76775 EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor phosphate-monoester phosphohydrolase (alkaline optimum) inhibitors http://purl.obolibrary.org/obo/CHEBI_63490 explosive http://purl.obolibrary.org/obo/CHEBI_51086 chemical role explosives chemicals http://purl.obolibrary.org/obo/CHEBI_64018 protein kinase C agonist http://purl.obolibrary.org/obo/CHEBI_64106 protein kinase agonist protein kinase C agonists http://purl.obolibrary.org/obo/CHEBI_65053 EC 4.1.1.19 (arginine decarboxylase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76906 EC 4.1.1.* (carboxy-lyase) inhibitor L-arginine carboxy-lyase (agmatine-forming) inhibitors http://purl.obolibrary.org/obo/CHEBI_65056 EC 3.1.3.11 (fructose-bisphosphatase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76775 EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor D-fructose-1,6-bisphosphate 1-phosphohydrolase inhibitors http://purl.obolibrary.org/obo/CHEBI_65057 adenosine A1 receptor agonist http://purl.obolibrary.org/obo/CHEBI_73311 adenosine receptor agonist adenosine A1 receptor agonists http://purl.obolibrary.org/obo/CHEBI_65064 EC 2.1.1.79 (cyclopropane-fatty-acyl-phospholipid synthase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76871 EC 2.1.1.* (methyltransferases) inhibitor S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclizing) inhibitors http://purl.obolibrary.org/obo/CHEBI_65065 EC 2.1.1.72 [site-specific DNA-methyltransferase (adenine-specific)] inhibitor http://purl.obolibrary.org/obo/CHEBI_76871 EC 2.1.1.* (methyltransferases) inhibitor EC 2.1.1.72 (site-specific DNA-methyltransferase (adenine-specific)) inhibitors http://purl.obolibrary.org/obo/CHEBI_65207 vascular endothelial growth factor receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist vascular endothelial growth factor receptor antagonists http://purl.obolibrary.org/obo/CHEBI_65232 EC 3.4.21.5 (thrombin) inhibitor http://purl.obolibrary.org/obo/CHEBI_5924 EC 3.4.21.* (serine endopeptidase) inhibitor tropostasin inhibitors http://purl.obolibrary.org/obo/CHEBI_66956 antidyskinesia agent http://purl.obolibrary.org/obo/CHEBI_23888 drug antidyskinetic drugs http://purl.obolibrary.org/obo/CHEBI_66980 nootropic agent http://purl.obolibrary.org/obo/CHEBI_23888 drug smart drugs http://purl.obolibrary.org/obo/CHEBI_68612 EC 3.4.14.5 (dipeptidyl-peptidase IV) inhibitor http://purl.obolibrary.org/obo/CHEBI_76788 EC 3.4.14.* (dipeptidyl- and tripeptidyl-peptidases) inhibitor postproline dipeptidyl aminopeptidase IV inhibitor http://purl.obolibrary.org/obo/CHEBI_70709 progesterone receptor agonist http://purl.obolibrary.org/obo/CHEBI_51060 hormone agonist progesterone receptor agonists http://purl.obolibrary.org/obo/CHEBI_70770 Aurora kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_37699 protein kinase inhibitor Aurora kinase inhibitors http://purl.obolibrary.org/obo/CHEBI_71181 Sir2 inhibitor http://purl.obolibrary.org/obo/CHEBI_61115 EC 3.5.1.98 (histone deacetylase) inhibitor Sir2 inhibitors http://purl.obolibrary.org/obo/CHEBI_71212 prohormone http://purl.obolibrary.org/obo/CHEBI_24432 biological role prohormones http://purl.obolibrary.org/obo/CHEBI_72854 EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76837 EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor EC 1.13.11.52 (indoleamine 2,3-dioxygenase) inhibitors http://purl.obolibrary.org/obo/CHEBI_73181 EC 1.11.1.11 (L-ascorbate peroxidase) inhibitors http://purl.obolibrary.org/obo/CHEBI_75381 EC 1.11.1.* (peroxidases) inhibitor L-ascorbate:hydrogen-peroxide oxidoreductase inhibitors http://purl.obolibrary.org/obo/CHEBI_74529 antidote to paracetamol poisoning http://purl.obolibrary.org/obo/CHEBI_50247 antidote paracetamol poisoning antidotes http://purl.obolibrary.org/obo/CHEBI_76779 EC 3.4.21.26 (prolyl oligopeptidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_5924 EC 3.4.21.* (serine endopeptidase) inhibitor prolyl oligopeptidase inhibitor http://purl.obolibrary.org/obo/CHEBI_77020 EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor http://purl.obolibrary.org/obo/CHEBI_77019 EC 1.10.99.* (oxidoreductases acting on diphenols and related substances as donors, other acceptors) inhibitor N-ribosyldihydronicotinamide dehydrogenase (quinone) inhibitors http://purl.obolibrary.org/obo/CHEBI_77034 mucolytic http://purl.obolibrary.org/obo/CHEBI_23888 drug mucolytics http://purl.obolibrary.org/obo/CHEBI_77089 EC 2.5.1.49 (O-acetylhomoserine aminocarboxypropyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76663 EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor EC 2.5.1.49 (O-acetylhomoserine aminocarboxypropyltransferase) inhibitors http://purl.obolibrary.org/obo/CHEBI_77108 EC 1.1.1.141 [15-hydroxyprostaglandin dehydrogenase (NAD(+))] inhibitor http://purl.obolibrary.org/obo/CHEBI_76835 EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (type I) inhibitor http://purl.obolibrary.org/obo/CHEBI_77110 EC 1.21.3.3 (reticuline oxidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_77109 EC 1.21.3.* (oxidoreductase acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor) inhibitor (S)-reticuline:oxygen oxidoreductase (methylene-bridge-forming) inhibitors http://purl.obolibrary.org/obo/CHEBI_77111 EC 2.1.1.116 [3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase] inhibitor http://purl.obolibrary.org/obo/CHEBI_76871 EC 2.1.1.* (methyltransferases) inhibitor S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_77113 EC 2.7.11.10 (IkappaB kinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76812 EC 2.7.11.* (protein-serine/threonine kinase) inhibitor TBK1 inhibitors http://purl.obolibrary.org/obo/CHEBI_77115 EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor http://purl.obolibrary.org/obo/CHEBI_76871 EC 2.1.1.* (methyltransferases) inhibitor tetrahydroprotoberberine cis-N-methyltransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_77119 EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76835 EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor (5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate:NADP(+) 9-oxidoreductase inhibitors http://purl.obolibrary.org/obo/CHEBI_77182 food colouring http://purl.obolibrary.org/obo/CHEBI_64047 food additive food colourings http://purl.obolibrary.org/obo/CHEBI_77194 EC 2.7.1.33 (pantothenate kinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76881 EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor ATP:(R)-pantothenate 4'-phosphotransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_77965 food anticaking agent http://purl.obolibrary.org/obo/CHEBI_64047 food additive food anticaking agent http://purl.obolibrary.org/obo/CHEBI_77966 food stabiliser http://purl.obolibrary.org/obo/CHEBI_64047 food additive stabilizers http://purl.obolibrary.org/obo/CHEBI_77969 food humectant http://purl.obolibrary.org/obo/CHEBI_64047 food additive food humectants http://purl.obolibrary.org/obo/CHEBI_77970 food thickening agent http://purl.obolibrary.org/obo/CHEBI_64047 food additive thickening agents http://purl.obolibrary.org/obo/CHEBI_77971 raising agent http://purl.obolibrary.org/obo/CHEBI_64047 food additive raising agents http://purl.obolibrary.org/obo/CHEBI_78004 food bulking agent http://purl.obolibrary.org/obo/CHEBI_64047 food additive food bulking agents http://purl.obolibrary.org/obo/CHEBI_78017 food propellant http://purl.obolibrary.org/obo/CHEBI_76414 propellant food propellants http://purl.obolibrary.org/obo/CHEBI_78295 food component http://purl.obolibrary.org/obo/CHEBI_52211 physiological role food components http://purl.obolibrary.org/obo/CHEBI_78299 environmental food contaminant http://purl.obolibrary.org/obo/CHEBI_78295 food component environmental food contaminants http://purl.obolibrary.org/obo/CHEBI_78433 refrigerant http://purl.obolibrary.org/obo/CHEBI_33232 application refrigerants http://purl.obolibrary.org/obo/CHEBI_78444 EC 3.1.1.1 (carboxylesterase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76773 EC 3.1.1.* (carboxylic ester hydrolase) inhibitor vitamin A esterase inhibitors http://purl.obolibrary.org/obo/CHEBI_78691 EC 2.3.1.97 (glycylpeptide N-tetradecanoyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76878 EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor EC 2.3.1.97 (glycylpeptide N-tetradecanoyltransferase) inhibitors http://purl.obolibrary.org/obo/CHEBI_78947 archaeal metabolite http://purl.obolibrary.org/obo/CHEBI_75787 prokaryotic metabolite archaeal metabolites http://purl.obolibrary.org/obo/CHEBI_83038 Daphnia galeata metabolite http://purl.obolibrary.org/obo/CHEBI_83057 Daphnia metabolite Daphnia galeata metabolites http://purl.obolibrary.org/obo/CHEBI_84264 EC 3.5.1.19 (nicotinamidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76807 EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor nicotinamide deaminase inhibitors http://purl.obolibrary.org/obo/CHEBI_85046 skin lightening agent http://purl.obolibrary.org/obo/CHEBI_64857 cosmetic skin whitening agents http://purl.obolibrary.org/obo/CHEBI_90172 c-Jun N-terminal kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_79091 EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor c-Jun N-terminal kinase inhibitors http://purl.obolibrary.org/obo/CHEBI_22695 base http://purl.obolibrary.org/obo/CHEBI_51086 chemical role bases http://purl.obolibrary.org/obo/CHEBI_24002 ethylene releasers http://purl.obolibrary.org/obo/CHEBI_26155 plant growth regulator ethylene releasers http://purl.obolibrary.org/obo/CHEBI_25605 nucleoside antibiotic http://purl.obolibrary.org/obo/CHEBI_33281 antimicrobial agent nucleoside antibiotics http://purl.obolibrary.org/obo/CHEBI_35544 EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76840 EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitors http://purl.obolibrary.org/obo/CHEBI_35569 alpha-adrenergic agonist http://purl.obolibrary.org/obo/CHEBI_48539 alpha-adrenergic drug alpha-adrenoceptor agonists http://purl.obolibrary.org/obo/CHEBI_38147 cardiotonic drug http://purl.obolibrary.org/obo/CHEBI_35554 cardiovascular drug cardiotonic drugs http://purl.obolibrary.org/obo/CHEBI_38500 EC 1.9.3.1 (cytochrome c oxidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_25355 mitochondrial respiratory-chain inhibitor complex IV (mitochondrial electron transport) inhibitors http://purl.obolibrary.org/obo/CHEBI_38637 tyrosine kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_37699 protein kinase inhibitor tyrphostins http://purl.obolibrary.org/obo/CHEBI_38807 calcium channel agonist http://purl.obolibrary.org/obo/CHEBI_38808 calcium channel modulator calcium channel agonists http://purl.obolibrary.org/obo/CHEBI_38808 calcium channel modulator http://purl.obolibrary.org/obo/CHEBI_38632 membrane transport modulator calcium channel modulators http://purl.obolibrary.org/obo/CHEBI_38941 schistosomicide drug http://purl.obolibrary.org/obo/CHEBI_35684 antiplatyhelmintic drug schistosomicides http://purl.obolibrary.org/obo/CHEBI_39276 fumigant http://purl.obolibrary.org/obo/CHEBI_25944 pesticide fumigants http://purl.obolibrary.org/obo/CHEBI_47867 indicator http://purl.obolibrary.org/obo/CHEBI_33232 application Indikator http://purl.obolibrary.org/obo/CHEBI_48353 serine proteinase inhibitor http://purl.obolibrary.org/obo/CHEBI_5924 EC 3.4.21.* (serine endopeptidase) inhibitor serine proteinase inhibitors http://purl.obolibrary.org/obo/CHEBI_48873 cholinergic antagonist http://purl.obolibrary.org/obo/CHEBI_38323 cholinergic drug cholinergic-blocking agents http://purl.obolibrary.org/obo/CHEBI_48878 nicotinic antagonist http://purl.obolibrary.org/obo/CHEBI_48873 cholinergic antagonist nicotinic cholinergic agonist http://purl.obolibrary.org/obo/CHEBI_50671 antithyroid drug http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist antithyroid drugs http://purl.obolibrary.org/obo/CHEBI_50684 cross-linking reagent http://purl.obolibrary.org/obo/CHEBI_33893 reagent cross-linking reagents http://purl.obolibrary.org/obo/CHEBI_50748 antipsoriatic http://purl.obolibrary.org/obo/CHEBI_50177 dermatologic drug antipsoriatic drug http://purl.obolibrary.org/obo/CHEBI_50781 EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor http://purl.obolibrary.org/obo/CHEBI_76857 EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor 3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+)) inhibitors http://purl.obolibrary.org/obo/CHEBI_50846 immunomodulator http://purl.obolibrary.org/obo/CHEBI_23888 drug immunomodulators http://purl.obolibrary.org/obo/CHEBI_50908 hepatotoxic agent http://purl.obolibrary.org/obo/CHEBI_52209 aetiopathogenetic role hepatoxicant http://purl.obolibrary.org/obo/CHEBI_55323 antidiarrhoeal drug http://purl.obolibrary.org/obo/CHEBI_55324 gastrointestinal drug antiperistaltics http://purl.obolibrary.org/obo/CHEBI_62803 fuel additive http://purl.obolibrary.org/obo/CHEBI_51086 chemical role fuel enhancer http://purl.obolibrary.org/obo/CHEBI_63047 food emulsifier http://purl.obolibrary.org/obo/CHEBI_63046 emulsifier food emulsifiers http://purl.obolibrary.org/obo/CHEBI_63510 EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76895 EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor sodium-potassium adenosine triphosphatase inhibitors http://purl.obolibrary.org/obo/CHEBI_64416 EC 1.3.1.43 (arogenate dehydrogenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76857 EC 1.3.1.* (oxidoreductase acting on donor CH-CH group, NAD(+) or NADP(+) as acceptor) inhibitor L-arogenate:NAD(+) oxidoreductase (decarboxylating) inhibitor http://purl.obolibrary.org/obo/CHEBI_64477 monolignol http://purl.obolibrary.org/obo/CHEBI_76924 plant metabolite monolignols http://purl.obolibrary.org/obo/CHEBI_64763 EC 3.1.4.11 (phosphoinositide phospholipase C) inhibitor http://purl.obolibrary.org/obo/CHEBI_50218 EC 3.1.4.* (phosphoric diester hydrolase) inhibitor phosphatidylinositol-specific phospholipase C inhibitors http://purl.obolibrary.org/obo/CHEBI_64951 anti-HBV agent http://purl.obolibrary.org/obo/CHEBI_22587 antiviral agent anti-hepatitis B virus agents http://purl.obolibrary.org/obo/CHEBI_67195 gap junctional intercellular communication inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor gap junctional intercellular communication inhibitors http://purl.obolibrary.org/obo/CHEBI_70998 G-protein-coupled receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist GPCR agonists http://purl.obolibrary.org/obo/CHEBI_73136 EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor http://purl.obolibrary.org/obo/CHEBI_76835 EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor EC 1.1.1.184 (carbonyl reductase (NADPH)) inhibitor http://purl.obolibrary.org/obo/CHEBI_74213 EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76848 EC 1.17.4.* (oxidoreductase acting on CH or CH2 with a disulfide as acceptor) inhibitor ribonucleoside-diphosphate reductase (EC 1.17.4.1) inhibitor http://purl.obolibrary.org/obo/CHEBI_75050 chromogenic compound http://purl.obolibrary.org/obo/CHEBI_50411 one-colour indicator chromogens http://purl.obolibrary.org/obo/CHEBI_75325 cathartic http://purl.obolibrary.org/obo/CHEBI_52208 biophysical role cathartics http://purl.obolibrary.org/obo/CHEBI_76891 EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76787 EC 3.4.11.* (aminopeptidase) inhibitor thiol-activated aminopeptidase inhibitors http://purl.obolibrary.org/obo/CHEBI_76893 EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor http://purl.obolibrary.org/obo/CHEBI_76788 EC 3.4.14.* (dipeptidyl- and tripeptidyl-peptidases) inhibitor dipeptidylarylamidase inhibitors http://purl.obolibrary.org/obo/CHEBI_77035 expectorant http://purl.obolibrary.org/obo/CHEBI_23888 drug expectorants http://purl.obolibrary.org/obo/CHEBI_77118 EC 3.5.5.1 (nitrilase) inhhibitor http://purl.obolibrary.org/obo/CHEBI_77117 EC 3.5.5.* (hydrolase acting on C-N bonds in nitriles) inhibitor nitrile aminohydrolase inhhibitors http://purl.obolibrary.org/obo/CHEBI_77326 androstane receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist constitutive androstane receptor agonists http://purl.obolibrary.org/obo/CHEBI_77703 EC 4.3.1.3 (histidine ammonia-lyase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76832 EC 4.3.1.* (ammonia-lyase) inhibitor histidine ammonia-lyase inhibitors http://purl.obolibrary.org/obo/CHEBI_78003 food bleaching agent http://purl.obolibrary.org/obo/CHEBI_64047 food additive food bleaching agents http://purl.obolibrary.org/obo/CHEBI_78016 food gelling agent http://purl.obolibrary.org/obo/CHEBI_64047 food additive food gelling agents http://purl.obolibrary.org/obo/CHEBI_79056 plasticiser http://purl.obolibrary.org/obo/CHEBI_33232 application plasticizers http://purl.obolibrary.org/obo/CHEBI_35660 HIV protease inhibitor http://purl.obolibrary.org/obo/CHEBI_64946 anti-HIV agent HIV protease inhibitors http://purl.obolibrary.org/obo/CHEBI_35678 histamine agonist http://purl.obolibrary.org/obo/CHEBI_37957 histaminergic drug histamine agonists http://purl.obolibrary.org/obo/CHEBI_35684 antiplatyhelmintic drug http://purl.obolibrary.org/obo/CHEBI_35443 anthelminthic drug antiplatyhelmintic drugs http://purl.obolibrary.org/obo/CHEBI_37887 adrenergic antagonist http://purl.obolibrary.org/obo/CHEBI_37962 adrenergic agent adrenoceptor antagonists http://purl.obolibrary.org/obo/CHEBI_39259 pyrethroid ester acaricide http://purl.obolibrary.org/obo/CHEBI_22153 acaricide pyrethroid ester acaricides http://purl.obolibrary.org/obo/CHEBI_48278 serotonergic drug http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent serotonin drugs http://purl.obolibrary.org/obo/CHEBI_48539 alpha-adrenergic drug http://purl.obolibrary.org/obo/CHEBI_37962 adrenergic agent alpha-adrenergic drugs http://purl.obolibrary.org/obo/CHEBI_48676 fibrin modulating drug http://purl.obolibrary.org/obo/CHEBI_23888 drug fibrin modulating drugs http://purl.obolibrary.org/obo/CHEBI_49326 synthetic oral contraceptive http://purl.obolibrary.org/obo/CHEBI_49325 oral contraceptive synthetic oral contraceptives http://purl.obolibrary.org/obo/CHEBI_50103 excitatory amino acid agonist http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent excitatory amino acid receptor agonists http://purl.obolibrary.org/obo/CHEBI_50137 mu-opioid receptor antagonist http://purl.obolibrary.org/obo/CHEBI_60605 opioid receptor antagonist mu-opioid receptor antagonists http://purl.obolibrary.org/obo/CHEBI_50241 cholinesterase reactivator http://purl.obolibrary.org/obo/CHEBI_50242 enzyme reactivator cholinesterase reactivators http://purl.obolibrary.org/obo/CHEBI_50407 acid-base indicator http://purl.obolibrary.org/obo/CHEBI_50410 colour indicator indicateur acide-base http://purl.obolibrary.org/obo/CHEBI_50412 two-colour indicator http://purl.obolibrary.org/obo/CHEBI_50410 colour indicator two-colour indicator http://purl.obolibrary.org/obo/CHEBI_50568 EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor http://purl.obolibrary.org/obo/CHEBI_50218 EC 3.1.4.* (phosphoric diester hydrolase) inhibitor 3',5'-cyclic nucleoside monophosphate phosphodiesterase inhibitors http://purl.obolibrary.org/obo/CHEBI_50691 abortifacient http://purl.obolibrary.org/obo/CHEBI_50689 reproductive control drug abortifacients http://purl.obolibrary.org/obo/CHEBI_50741 retinoic acid receptor alpha/beta agonist http://purl.obolibrary.org/obo/CHEBI_67198 retinoic acid receptor agonist RAR alpha/beta agonist http://purl.obolibrary.org/obo/CHEBI_50788 EC 1.1.1.210 [3beta(or 20alpha)-hydroxysteroid dehydrogenase] inhibitor http://purl.obolibrary.org/obo/CHEBI_76835 EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor 3beta,20alpha-hydroxysteroid oxidoreductase inhibitors http://purl.obolibrary.org/obo/CHEBI_50792 estrogen receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist estrogen receptor antagonists http://purl.obolibrary.org/obo/CHEBI_50837 estrogen antagonist http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist oestrogen antagonist http://purl.obolibrary.org/obo/CHEBI_50864 insulin-sensitizing drug http://purl.obolibrary.org/obo/CHEBI_70781 PPAR modulator peroxisome proliferator-activated receptor gamma agonist http://purl.obolibrary.org/obo/CHEBI_50913 fixative http://purl.obolibrary.org/obo/CHEBI_24432 biological role fixation agent http://purl.obolibrary.org/obo/CHEBI_53353 GHB receptor agonist http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent GHB receptor agonists http://purl.obolibrary.org/obo/CHEBI_53659 EC 1.4.3.22 (diamine oxidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76861 EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor histamine:oxygen oxidoreductase (deaminating) inhibitor http://purl.obolibrary.org/obo/CHEBI_59010 antiseborrheic http://purl.obolibrary.org/obo/CHEBI_50177 dermatologic drug antiseborrheics http://purl.obolibrary.org/obo/CHEBI_59229 GnRH antagonist http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist gonadotrophin-releasing hormone antagonists http://purl.obolibrary.org/obo/CHEBI_59282 kappa-opioid receptor agonist http://purl.obolibrary.org/obo/CHEBI_60606 opioid receptor agonist kappa-opioid receptor agonists http://purl.obolibrary.org/obo/CHEBI_59283 delta-opioid receptor antagonist http://purl.obolibrary.org/obo/CHEBI_60601 delta-opioid agent delta-opioid antagonists http://purl.obolibrary.org/obo/CHEBI_59285 EC 1.14.13.132 (squalene monooxygenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76841 EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor squalene-2,3-epoxide cyclase inhibitors http://purl.obolibrary.org/obo/CHEBI_59321 EC 4.1.1.28 (aromatic-L-amino-acid decarboxylase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76906 EC 4.1.1.* (carboxy-lyase) inhibitor tryptophan decarboxylase inhibitors http://purl.obolibrary.org/obo/CHEBI_59680 vasopressin receptor antagonist http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist vasopressin receptor antagonists http://purl.obolibrary.org/obo/CHEBI_59941 amphiphile http://purl.obolibrary.org/obo/CHEBI_35195 surfactant amphiphiles http://purl.obolibrary.org/obo/CHEBI_60186 EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76895 EC 3.6.3.* (acid anhydride hydrolase catalysing transmembrane movement of substances) inhibitor sarco(endo)plasmic reticulum Ca(2+)-ATPase inhibitor http://purl.obolibrary.org/obo/CHEBI_62608 EC 4.2.1.3 (aconitate hydratase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76907 EC 4.2.1.* (hydro-lyases) inhibitor citrate(isocitrate) hydro-lyase inhibitors http://purl.obolibrary.org/obo/CHEBI_65191 second generation antipsychotic http://purl.obolibrary.org/obo/CHEBI_35476 antipsychotic agent second generation antipsychotics http://purl.obolibrary.org/obo/CHEBI_65265 antacid http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role antacids http://purl.obolibrary.org/obo/CHEBI_73263 cyclooxygenase 3 inhibitor http://purl.obolibrary.org/obo/CHEBI_35544 EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor cyclooxygenase-3 inhibitors http://purl.obolibrary.org/obo/CHEBI_73296 cholecystokinin antagonist http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist cholecystokinin antagonists http://purl.obolibrary.org/obo/CHEBI_73333 scabicide http://purl.obolibrary.org/obo/CHEBI_22153 acaricide scabicides http://purl.obolibrary.org/obo/CHEBI_74352 quinol oxidation site inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor quinol oxidation site inhibitors http://purl.obolibrary.org/obo/CHEBI_76498 coral metabolite http://purl.obolibrary.org/obo/CHEBI_75767 animal metabolite coral metabolites http://purl.obolibrary.org/obo/CHEBI_77178 histological dye http://purl.obolibrary.org/obo/CHEBI_37958 dye histological stains http://purl.obolibrary.org/obo/CHEBI_77567 eugeroic http://purl.obolibrary.org/obo/CHEBI_35471 psychotropic drug wakefulness-promoting drugs http://purl.obolibrary.org/obo/CHEBI_77608 loop diuretic http://purl.obolibrary.org/obo/CHEBI_35498 diuretic loop diuretics http://purl.obolibrary.org/obo/CHEBI_77884 EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor http://purl.obolibrary.org/obo/CHEBI_83734 sterol demethylation inhibitor EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitors http://purl.obolibrary.org/obo/CHEBI_78606 Hsp70 inducer http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role heat shock protein 70 inducers http://purl.obolibrary.org/obo/CHEBI_85540 thromboxane A2 antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist thromboxane A2 receptor antagonists http://purl.obolibrary.org/obo/CHEBI_90318 EC 6.4.1.1 (pyruvate carboxylase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76824 EC 6.4.1.* (carboxylase) inhibitor pyruvate:carbon-dioxide ligase (ADP-forming) inhibitor http://purl.obolibrary.org/obo/CHEBI_90755 antidote to opioid poisoning http://purl.obolibrary.org/obo/CHEBI_50247 antidote antidote to opioid overdose http://purl.obolibrary.org/obo/CHEBI_33290 food http://purl.obolibrary.org/obo/CHEBI_52211 physiological role foodstuffs http://purl.obolibrary.org/obo/CHEBI_35477 antimanic drug http://purl.obolibrary.org/obo/CHEBI_35473 tranquilizing drug antimanics http://purl.obolibrary.org/obo/CHEBI_38634 voltage-gated sodium channel blocker http://purl.obolibrary.org/obo/CHEBI_38633 sodium channel blocker voltage-dependent sodium channel blockers http://purl.obolibrary.org/obo/CHEBI_38706 pediculicide http://purl.obolibrary.org/obo/CHEBI_24852 insecticide pediculicides http://purl.obolibrary.org/obo/CHEBI_64370 glutamate transporter activator http://purl.obolibrary.org/obo/CHEBI_64371 neurotransmitter transporter modulator glutamate transporter activators http://purl.obolibrary.org/obo/CHEBI_71031 orphan drug http://purl.obolibrary.org/obo/CHEBI_23888 drug orphan drugs http://purl.obolibrary.org/obo/CHEBI_74236 polymerisation monomer http://purl.obolibrary.org/obo/CHEBI_51086 chemical role polymerization monomer http://purl.obolibrary.org/obo/CHEBI_77960 food firming agent http://purl.obolibrary.org/obo/CHEBI_64047 food additive food firming agents http://purl.obolibrary.org/obo/CHEBI_83072 EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitor http://purl.obolibrary.org/obo/CHEBI_77102 EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor EC 1.3.5.1 [succinate dehydrogenase (quinone)] inhibitors http://purl.obolibrary.org/obo/CHEBI_84012 EC 4.2.1.94 (scytalone dehydratase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76907 EC 4.2.1.* (hydro-lyases) inhibitor scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming) inhibitor http://purl.obolibrary.org/obo/CHEBI_48357 aprotic solvent http://purl.obolibrary.org/obo/CHEBI_46787 solvent aprotic solvent http://purl.obolibrary.org/obo/CHEBI_48359 protophilic solvent http://purl.obolibrary.org/obo/CHEBI_48354 polar solvent protophilic solvent http://purl.obolibrary.org/obo/CHEBI_48406 EC 2.1.1.6 (catechol O-methyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76871 EC 2.1.1.* (methyltransferases) inhibitor catechol O-methyltransferase (EC 2.1.1.6) inhibitors http://purl.obolibrary.org/obo/CHEBI_48525 calcimimetic http://purl.obolibrary.org/obo/CHEBI_23888 drug calcimimetics http://purl.obolibrary.org/obo/CHEBI_50184 ion transport inhibitor http://purl.obolibrary.org/obo/CHEBI_38632 membrane transport modulator ion-transport inhibitors http://purl.obolibrary.org/obo/CHEBI_50269 EC 1.1.1.1 (alcohol dehydrogenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76835 EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor NAD-specific aromatic alcohol dehydrogenase inhibitor http://purl.obolibrary.org/obo/CHEBI_50664 matrix metalloproteinase inhibitor http://purl.obolibrary.org/obo/CHEBI_60258 EC 3.4.* (hydrolases acting on peptide bond) inhibitor matrix metalloproteinase inhibitors http://purl.obolibrary.org/obo/CHEBI_5924 EC 3.4.21.* (serine endopeptidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_60258 EC 3.4.* (hydrolases acting on peptide bond) inhibitor serine endopeptidase inhibitors http://purl.obolibrary.org/obo/CHEBI_59844 antihyperplasia drug http://purl.obolibrary.org/obo/CHEBI_23888 drug antihyperplastic http://purl.obolibrary.org/obo/CHEBI_63562 glucocorticoid receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist glucocorticoid receptor agonists http://purl.obolibrary.org/obo/CHEBI_63923 sclerotherapy agent http://purl.obolibrary.org/obo/CHEBI_24432 biological role sclerotherapy agents http://purl.obolibrary.org/obo/CHEBI_64133 EC 2.5.1.58 (protein farnesyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76663 EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor farnesyl-diphosphate:protein-cysteine farnesyltransferase inhibitors http://purl.obolibrary.org/obo/CHEBI_64338 K-ATP channel agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist K-ATP channel agonists http://purl.obolibrary.org/obo/CHEBI_68844 phosphodiesterase IV inhibitor http://purl.obolibrary.org/obo/CHEBI_77758 EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor type 4 phosphodiesterase inhibitors http://purl.obolibrary.org/obo/CHEBI_72773 carotogenesis inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor carotogenesis inhibitors http://purl.obolibrary.org/obo/CHEBI_72774 EC 1.3.99.29 [phytoene desaturase (zeta-carotene-forming)] inhibitor http://purl.obolibrary.org/obo/CHEBI_76859 EC 1.3.99.* (oxidoreductase acting on donor CH-CH group, with other acceptors) inhibitor 15-cis-phytoene:acceptor oxidoreductase (zeta-carotene-forming) inhibitors http://purl.obolibrary.org/obo/CHEBI_74136 lachrymator http://purl.obolibrary.org/obo/CHEBI_52208 biophysical role lachrymators http://purl.obolibrary.org/obo/CHEBI_76648 fluorescence quencher http://purl.obolibrary.org/obo/CHEBI_51086 chemical role fluorescence quenchers http://purl.obolibrary.org/obo/CHEBI_77023 EC 2.3.3.1 [citrate (Si)-synthase] inhibitor http://purl.obolibrary.org/obo/CHEBI_77022 EC 2.3.3.* (acyltransferase converting acyl to alkyl group on transfer) inhibitor acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming] inhibitor http://purl.obolibrary.org/obo/CHEBI_77024 EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76775 EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor xK-pNPPase inhibitors http://purl.obolibrary.org/obo/CHEBI_79093 EC 1.11.2.2 (myeloperoxidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_79092 EC 1.11.2.* (oxidoreductase with H2O2 as acceptor, incorporating 1 O atom into product) inhibitor chloride:hydrogen-peroxide oxidoreductase (hypochlorite-forming) inhibitors http://purl.obolibrary.org/obo/CHEBI_82973 EC 3.4.24.11 (neprilysin) inhibitor http://purl.obolibrary.org/obo/CHEBI_59107 EC 3.4.24.* (metalloendopeptidase) inhibitor kidney-brush-border neutral endopeptidase inhibitors http://purl.obolibrary.org/obo/CHEBI_82974 EC 3.4.24.71 (endothelin-converting enzyme 1) inhibitor http://purl.obolibrary.org/obo/CHEBI_59107 EC 3.4.24.* (metalloendopeptidase) inhibitor endothelin-converting enzyme 1 (EC 3.4.24.71) inhibitor http://purl.obolibrary.org/obo/CHEBI_84799 EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76878 EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitors http://purl.obolibrary.org/obo/CHEBI_84800 EC 2.4.1.1 (glycogen phosphorylase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76789 EC 2.4.1.* (hexosyltransferase) inhibitor 1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase inhibitors http://purl.obolibrary.org/obo/CHEBI_84801 EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76881 EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor inositol-trisphosphate 3-kinase (EC 2.7.1.127) inhibitor http://purl.obolibrary.org/obo/CHEBI_84802 EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76881 EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitors http://purl.obolibrary.org/obo/CHEBI_84804 EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_84803 EC 2.7.4.* (phosphotransferases with a phosphate group as acceptor) inhibitor nucleoside-diphosphate kinase (EC 2.7.4.6) inhibitor http://purl.obolibrary.org/obo/CHEBI_86385 EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor http://purl.obolibrary.org/obo/CHEBI_86383 EC 5.3.3.* (intramolecular oxidase transposing C=C bonds) inhibitor Delta(7)-cholestenol Delta(7)-Delta(8)-isomerase inhibitor http://purl.obolibrary.org/obo/CHEBI_86501 EC 1.14.13.97 (taurochenodeoxycholate 6alpha-hydroxylase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76841 EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor taurochenodeoxycholate 6alpha-hydroxylase inhibitors http://purl.obolibrary.org/obo/CHEBI_51076 antifouling biocide http://purl.obolibrary.org/obo/CHEBI_25944 pesticide Marine pesticide http://purl.obolibrary.org/obo/CHEBI_51166 Wittig reagent http://purl.obolibrary.org/obo/CHEBI_33893 reagent reactivos de Wittig http://purl.obolibrary.org/obo/CHEBI_51237 Grignard reagent http://purl.obolibrary.org/obo/CHEBI_33893 reagent Grignards Reagens http://purl.obolibrary.org/obo/CHEBI_51451 endothelin receptor antagonist http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist ERA http://purl.obolibrary.org/obo/CHEBI_52629 EC 3.1.26.13 (retroviral ribonuclease H) inhibitor http://purl.obolibrary.org/obo/CHEBI_76785 EC 3.1.26.* (endoribonucleases producing 5'-phosphomonoesters) inhibitor retroviral ribonuclease H (EC 3.1.26.13) inhibitors http://purl.obolibrary.org/obo/CHEBI_52941 phosphate protecting group http://purl.obolibrary.org/obo/CHEBI_51087 protecting group phosphate protecting groups http://purl.obolibrary.org/obo/CHEBI_52943 carboxylic acid protecting group http://purl.obolibrary.org/obo/CHEBI_51087 protecting group carboxylic acid protecting groups http://purl.obolibrary.org/obo/CHEBI_53337 tissue adhesive http://purl.obolibrary.org/obo/CHEBI_24432 biological role tissue adhesives http://purl.obolibrary.org/obo/CHEBI_63060 phase-transfer catalyst http://purl.obolibrary.org/obo/CHEBI_35223 catalyst phase-transfer catalysts http://purl.obolibrary.org/obo/CHEBI_67126 colorimetric reagent http://purl.obolibrary.org/obo/CHEBI_33893 reagent colour reagents http://purl.obolibrary.org/obo/CHEBI_72716 EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76877 EC 2.3.2.* (aminoacyltransferase) inhibitor R-glutaminyl-peptide:amine gamma-glutamyl transferase inhibitor http://purl.obolibrary.org/obo/CHEBI_73352 protein-sequencing agent http://purl.obolibrary.org/obo/CHEBI_33232 application sequencing agents http://purl.obolibrary.org/obo/CHEBI_73354 EC 2.7.3.2 (creatine kinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76818 EC 2.7.3.* (phosphotransferases with a nitrogenous group as acceptor) inhibitor creatine phosphokinase inhibitors http://purl.obolibrary.org/obo/CHEBI_73618 spectrophotometric reagent http://purl.obolibrary.org/obo/CHEBI_33893 reagent spectrophotometric reagents http://purl.obolibrary.org/obo/CHEBI_73623 tolerogen http://purl.obolibrary.org/obo/CHEBI_24432 biological role tolerogens http://purl.obolibrary.org/obo/CHEBI_73668 peptide coupling reagent http://purl.obolibrary.org/obo/CHEBI_33893 reagent peptide coupling reagents http://purl.obolibrary.org/obo/CHEBI_76761 EC 3.2.* (glycosylase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76759 EC 3.* (hydrolase) inhibitor glycosylase inhibitors http://purl.obolibrary.org/obo/CHEBI_76785 EC 3.1.26.* (endoribonucleases producing 5'-phosphomonoesters) inhibitor http://purl.obolibrary.org/obo/CHEBI_76760 EC 3.1.* (ester hydrolase) inhibitor EC 3.1.26.* (endoribonucleases producing 5'-phosphomonoesters) inhibitors http://purl.obolibrary.org/obo/CHEBI_66894 erythropeotin receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist erythropoiesis-stimulating agents http://purl.obolibrary.org/obo/CHEBI_66902 CFTR potentiator http://purl.obolibrary.org/obo/CHEBI_38632 membrane transport modulator cystic fibrosis transmembrane conductance regulator potentiator http://purl.obolibrary.org/obo/CHEBI_66908 SMO receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist smoothened receptor antagonists http://purl.obolibrary.org/obo/CHEBI_67072 cannabinoid receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist cannabinoid receptor agonists http://purl.obolibrary.org/obo/CHEBI_67137 NMR shift reagent http://purl.obolibrary.org/obo/CHEBI_33893 reagent nuclear magnetic resonance shift reagents http://purl.obolibrary.org/obo/CHEBI_67189 EC 3.4.24.3 (microbial collagenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_59107 EC 3.4.24.* (metalloendopeptidase) inhibitor soycollagestin inhibitors http://purl.obolibrary.org/obo/CHEBI_67230 EC 3.2.1.45 (glucosylceramidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_52424 EC 3.2.1.* (glycosidase) inhibitor D-glucosyl-N-acylsphingosine glucohydrolase inhibitors http://purl.obolibrary.org/obo/CHEBI_67231 EC 3.2.1.48 (sucrose alpha-glucosidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_52424 EC 3.2.1.* (glycosidase) inhibitor sucrose-alpha-D-glucohydrolase inhibitors http://purl.obolibrary.org/obo/CHEBI_70821 cathepsin L (EC 3.4.22.15) inhibitor http://purl.obolibrary.org/obo/CHEBI_76796 EC 3.4.22.* (cysteine endopeptidase) inhibitor cathepsin L1 inhibitors http://purl.obolibrary.org/obo/CHEBI_70822 EC 3.4.22.2 (papain) inhibitor http://purl.obolibrary.org/obo/CHEBI_76796 EC 3.4.22.* (cysteine endopeptidase) inhibitor velardon inhibitors http://purl.obolibrary.org/obo/CHEBI_71951 EC 3.5.1.88 (peptide deformylase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76807 EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor formyl-L-methionyl peptide amidohydrolase inhibitor http://purl.obolibrary.org/obo/CHEBI_72294 nerve growth factor stimulator http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent nerve growth factor stimulators http://purl.obolibrary.org/obo/CHEBI_73196 EC 4.4.1.11 (methionine gamma-lyase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76831 EC 4.4.1.* (C-S lyase) inhibitor methionine gamma-lyase inhibitors http://purl.obolibrary.org/obo/CHEBI_76822 EC 3.2.1.31 (beta-glucuronidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_52424 EC 3.2.1.* (glycosidase) inhibitor beta-D-glucuronoside glucuronosohydrolase inhibitors http://purl.obolibrary.org/obo/CHEBI_78505 venom http://purl.obolibrary.org/obo/CHEBI_27026 toxin venoms http://purl.obolibrary.org/obo/CHEBI_90708 retinoic acid receptor modulator http://purl.obolibrary.org/obo/CHEBI_90709 nuclear receptor modulator retinoic acid receptor modulators http://purl.obolibrary.org/obo/CHEBI_73730 PPARbeta/delta agonist http://purl.obolibrary.org/obo/CHEBI_70781 PPAR modulator peroxisome proliferator-activated receptor-delta agonist http://purl.obolibrary.org/obo/CHEBI_73911 vibriostatic agent http://purl.obolibrary.org/obo/CHEBI_33282 antibacterial agent vibriostatics http://purl.obolibrary.org/obo/CHEBI_74234 EC 1.1.1.153 [sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming)] inhibitor http://purl.obolibrary.org/obo/CHEBI_76835 EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor sepiapterin reductase (L-erythro-7,8-dihydrobiopterin forming) (EC 1.1.1.153) inhibitor http://purl.obolibrary.org/obo/CHEBI_74520 EC 1.1.1.44 (NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76835 EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor phosphogluconate dehydrogenase (NADP+ -dependent, decarboxylating) inhibitors http://purl.obolibrary.org/obo/CHEBI_74570 EC 2.3.2.2 (gamma-glutamyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76877 EC 2.3.2.* (aminoacyltransferase) inhibitor (5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase inhibitors http://purl.obolibrary.org/obo/CHEBI_74914 microarray analysis reagent http://purl.obolibrary.org/obo/CHEBI_33893 reagent microarray analysis reagents http://purl.obolibrary.org/obo/CHEBI_74949 EC 3.1.27.3 (ribonuclease T1) inhibitor http://purl.obolibrary.org/obo/CHEBI_76791 EC 3.1.27.* (endoribonucleases producing other than 5'-phosphomonoesters) inhibitor ribonuclease guaninenucleotido-2'-transferase (cyclizing) inhibitors http://purl.obolibrary.org/obo/CHEBI_75174 EC 2.5.1.21 (squalene synthase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76663 EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_75252 insulin-like growth factor receptor 1 antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist insulin-like growth factor receptor 1 antagonists http://purl.obolibrary.org/obo/CHEBI_75414 platelet-activating factor receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist platelet-activating factor receptor agonists http://purl.obolibrary.org/obo/CHEBI_76791 EC 3.1.27.* (endoribonucleases producing other than 5'-phosphomonoesters) inhibitor http://purl.obolibrary.org/obo/CHEBI_76760 EC 3.1.* (ester hydrolase) inhibitor inhibitor of endoribonucleases producing other than 5'-phosphomonoesters (EC 3.1.27.*) http://purl.obolibrary.org/obo/CHEBI_76829 EC 5.4.3.* (intramolecular transferase transferring amino groups) inhibitor http://purl.obolibrary.org/obo/CHEBI_76695 EC 5.4.* (intramolecular transferase) inhibitor inhibitor of intramolecular transferase transferring amino groups (EC 5.4.3.*) http://purl.obolibrary.org/obo/CHEBI_76848 EC 1.17.4.* (oxidoreductase acting on CH or CH2 with a disulfide as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76744 EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor oxidoreductase acting on CH or CH2 with a disulfide as acceptor (EC 1.17.4.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_76885 EC 3.4.23.* (aspartic endopeptidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_60258 EC 3.4.* (hydrolases acting on peptide bond) inhibitor aspartic endopeptidases (EC 3.4.23.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_78763 EC 2.7.11.18 (myosin-light-chain kinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76812 EC 2.7.11.* (protein-serine/threonine kinase) inhibitor ATP:myosin-light-chain O-phosphotransferase inhibitors http://purl.obolibrary.org/obo/CHEBI_85180 nonnucleoside hepatitis C virus polymerase inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role nonstructural protein 5B inhibitors http://purl.obolibrary.org/obo/CHEBI_85516 Human Antigen R Protein Expression Modulator and AkT Inhibitor http://purl.obolibrary.org/obo/CHEBI_24432 biological role ELAVL1 http://purl.obolibrary.org/obo/CHEBI_85618 EC 2.5.1.31 {ditrans,polycis-undecaprenyl-diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific]} inhibitor http://purl.obolibrary.org/obo/CHEBI_76663 EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor ditrans,polycis-undecaprenyl-diphosphate synthase inhibitors http://purl.obolibrary.org/obo/CHEBI_86009 EC 1.4.1.* (oxidoreductase acting on donor CH-NH2 group; NAD(+) or NADP(+) as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76730 EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor EC 1.4.1.* (oxidoreductase acting on donor CH-NH2 group; NAD(+) or NADP(+) as acceptor) inhibitors http://purl.obolibrary.org/obo/CHEBI_86010 EC 1.4.1.3 {glutamate dehydrogenase [NAD(P)(+)]} inhibitor http://purl.obolibrary.org/obo/CHEBI_86009 EC 1.4.1.* (oxidoreductase acting on donor CH-NH2 group; NAD(+) or NADP(+) as acceptor) inhibitor L-glutamate:NAD(P)(+) oxidoreductase (deaminating) inhibitor http://purl.obolibrary.org/obo/CHEBI_86383 EC 5.3.3.* (intramolecular oxidase transposing C=C bonds) inhibitor http://purl.obolibrary.org/obo/CHEBI_76694 EC 5.3.* (intramolecular oxidoreductase) inhibitor intramolecular oxidase transposing C=C bonds inhibitor (EC 5.3.3.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_86966 EC 3.4.21.92 (endopeptidase Clp) inhibitor http://purl.obolibrary.org/obo/CHEBI_5924 EC 3.4.21.* (serine endopeptidase) inhibitor protease Ti inhibitors http://purl.obolibrary.org/obo/NCBITaxon_1491 Clostridium botulinum http://www.bioassayontology.org/bao#BAO_0000364 bacterium Pacinia putrifica http://purl.obolibrary.org/obo/NCBITaxon_7955 Danio rerio http://www.bioassayontology.org/bao#BAO_0000518 non-mammalian Danio rerio frankei http://purl.obolibrary.org/obo/NCBITaxon_9913 Bos taurus http://www.bioassayontology.org/bao#BAO_0000362 mammalian dairy cow http://purl.obolibrary.org/obo/CLO_0037059 SU-DHL-10 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 SU-DHL-10 http://purl.obolibrary.org/obo/CLO_0037063 SU-DHL-6 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 SU-DHL-6 http://purl.obolibrary.org/obo/CLO_0037212 BJeLR cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 BJeLR http://purl.obolibrary.org/obo/CLO_0037213 BJeH cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 BJeLR http://www.bioassayontology.org/bao#BAO_0000761 3-isobutyl-1-methylanxthine http://www.bioassayontology.org/bao#BAO_0003043 molecular entity IBMX http://purl.obolibrary.org/obo/CHEBI_24127 fungicide http://purl.obolibrary.org/obo/CHEBI_35718 antifungal agent fungicides http://purl.obolibrary.org/obo/CHEBI_33286 agrochemical http://purl.obolibrary.org/obo/CHEBI_33232 application agrochemicals http://purl.obolibrary.org/obo/CHEBI_35625 EC 3.5.2.6 (beta-lactamase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76808 EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitor penicillinase inhibitors http://purl.obolibrary.org/obo/CHEBI_38499 mitochondrial cytochrome-bc1 complex inhibitor http://purl.obolibrary.org/obo/CHEBI_25355 mitochondrial respiratory-chain inhibitor mitochondrial complex III inhibitors http://purl.obolibrary.org/obo/CHEBI_50919 antiemetic http://purl.obolibrary.org/obo/CHEBI_23888 drug antiemetics http://purl.obolibrary.org/obo/CHEBI_77746 human metabolite http://purl.obolibrary.org/obo/CHEBI_75768 mammalian metabolite Homo sapiens metabolites http://purl.obolibrary.org/obo/CHEBI_35457 EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor http://purl.obolibrary.org/obo/CHEBI_76782 EC 3.4.15.* (peptidyl-dipeptidase) inhibitor peptidyldipeptide hydrolase inhibitors http://purl.obolibrary.org/obo/CHEBI_48425 topical anaesthetic http://purl.obolibrary.org/obo/CHEBI_36333 local anaesthetic topical anesthetic http://purl.obolibrary.org/obo/CHEBI_59683 antipruritic drug http://purl.obolibrary.org/obo/CHEBI_50177 dermatologic drug antipruritic drugs http://purl.obolibrary.org/obo/CHEBI_78804 Caenorhabditis elegans metabolite http://purl.obolibrary.org/obo/CHEBI_78803 nematode metabolite Caenorhabditis elegans metabolites http://purl.obolibrary.org/obo/CHEBI_48706 antagonist http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role antagonists http://purl.obolibrary.org/obo/CHEBI_59544 phosphoantigen http://purl.obolibrary.org/obo/CHEBI_59132 antigen phosphoantigens http://purl.obolibrary.org/obo/CHEBI_82824 calpain inhibitor http://purl.obolibrary.org/obo/CHEBI_76796 EC 3.4.22.* (cysteine endopeptidase) inhibitor calpain inhibitors http://purl.obolibrary.org/obo/CHEBI_26842 systemic acquired resistance inducing compounds http://purl.obolibrary.org/obo/CHEBI_35703 xenobiotic systemic acquired resistance inducing compounds http://purl.obolibrary.org/obo/CHEBI_27334 xenobiotic organic ethers http://purl.obolibrary.org/obo/CHEBI_35703 xenobiotic xenobiotic organic ethers http://purl.obolibrary.org/obo/CHEBI_33289 avicide http://purl.obolibrary.org/obo/CHEBI_25944 pesticide avicides http://purl.obolibrary.org/obo/CHEBI_35634 EC 1.17.3.2 (xanthine oxidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76850 EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitor xanthine:xanthine oxidase inhibitors http://purl.obolibrary.org/obo/CHEBI_35816 leprostatic drug http://purl.obolibrary.org/obo/CHEBI_64912 antimycobacterial drug leprostatic drugs http://purl.obolibrary.org/obo/CHEBI_35818 coccidiostat http://purl.obolibrary.org/obo/CHEBI_35820 antiprotozoal drug coccidiostats http://purl.obolibrary.org/obo/CHEBI_35842 antirheumatic drug http://purl.obolibrary.org/obo/CHEBI_23888 drug antirheumatic drugs http://purl.obolibrary.org/obo/CHEBI_36333 local anaesthetic http://purl.obolibrary.org/obo/CHEBI_38867 anaesthetic local anesthetics http://purl.obolibrary.org/obo/CHEBI_37416 EC 2.7.7.6 (RNA polymerase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76815 EC 2.7.7.* (nucleotidyltransferase) inhibitor nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) inhibitor http://purl.obolibrary.org/obo/CHEBI_37955 H1-receptor antagonist http://purl.obolibrary.org/obo/CHEBI_37956 histamine antagonist classical antihistaminics http://purl.obolibrary.org/obo/CHEBI_38323 cholinergic drug http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent cholinomimetic http://purl.obolibrary.org/obo/CHEBI_38498 mitochondrial NADH:ubiquinone reductase inhibitor http://purl.obolibrary.org/obo/CHEBI_25355 mitochondrial respiratory-chain inhibitor mitochondrial complex I inhibitors http://purl.obolibrary.org/obo/CHEBI_38809 ryanodine receptor modulator http://purl.obolibrary.org/obo/CHEBI_38808 calcium channel modulator ryanodine-sensitive calcium-release channel modulator http://purl.obolibrary.org/obo/CHEBI_50188 provitamin http://purl.obolibrary.org/obo/CHEBI_24432 biological role provitamins http://purl.obolibrary.org/obo/CHEBI_50423 EC 1.6.3.1. [NAD(P)H oxidase (H2O2-forming)] inhibitor http://purl.obolibrary.org/obo/CHEBI_76867 EC 1.6.3.* (oxidoreductase acting on NADH or NADPH with oxygen as acceptor) inhibitor NAD(P)H:oxygen oxidoreductase (H2O2-forming) inhibitor http://purl.obolibrary.org/obo/CHEBI_50635 EC 3.5.1.5 (urease) inhibitor http://purl.obolibrary.org/obo/CHEBI_76807 EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor urease inhibitors http://purl.obolibrary.org/obo/CHEBI_51068 miotic http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent miotics http://purl.obolibrary.org/obo/CHEBI_53142 P2Y2 receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist P2Y2 receptor agonists http://purl.obolibrary.org/obo/CHEBI_60901 EC 2.5.1.9 (riboflavin synthase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76663 EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor 6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase inhibitors http://purl.obolibrary.org/obo/CHEBI_63932 EC 1.14.16.2 (tyrosine 3-monooxygenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76847 EC 1.14.16.* (oxidoreductase acting on paired donors, reduced pteridine as one donor, incorporating 1 atom of oxygen) inhibitor tyrosine hydroxylase inhibitors http://purl.obolibrary.org/obo/CHEBI_64047 food additive http://purl.obolibrary.org/obo/CHEBI_78295 food component food additives http://purl.obolibrary.org/obo/CHEBI_64176 H3-receptor antagonist http://purl.obolibrary.org/obo/CHEBI_37956 histamine antagonist histamine H3-receptor antagonists http://purl.obolibrary.org/obo/CHEBI_64933 melanin synthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_59864 depigmentation drug melanogenesis inhibitors http://purl.obolibrary.org/obo/CHEBI_64946 anti-HIV agent http://purl.obolibrary.org/obo/CHEBI_22587 antiviral agent anti-HIV agents http://purl.obolibrary.org/obo/CHEBI_65190 first generation antipsychotic http://purl.obolibrary.org/obo/CHEBI_35476 antipsychotic agent typical antipsychotics http://purl.obolibrary.org/obo/CHEBI_71232 adenosine receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist adenosine receptor antagonists http://purl.obolibrary.org/obo/CHEBI_73190 antimutagen http://purl.obolibrary.org/obo/CHEBI_24432 biological role antimutagens http://purl.obolibrary.org/obo/CHEBI_74530 antidote to curare poisoning http://purl.obolibrary.org/obo/CHEBI_50247 antidote tubocurarine antidotes http://purl.obolibrary.org/obo/CHEBI_75358 curing agent http://purl.obolibrary.org/obo/CHEBI_33232 application vulcanizing agents http://purl.obolibrary.org/obo/CHEBI_77484 EC 1.1.1.25 (shikimate dehydrogenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76835 EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor shikimate:NADP(+) oxidoreductase inhibitors http://purl.obolibrary.org/obo/CHEBI_77706 EC 3.4.19.3 (pyroglutamyl-peptidase I) inhibitor http://purl.obolibrary.org/obo/CHEBI_77705 EC 3.4.19.* (omega-peptidase) inhibitor pyrrolidonyl peptidase inhibitor http://purl.obolibrary.org/obo/CHEBI_77781 EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76841 EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitors http://purl.obolibrary.org/obo/CHEBI_83146 Daphnia tenebrosa metabolite http://purl.obolibrary.org/obo/CHEBI_83057 Daphnia metabolite Daphnia tenebrosa metabolites http://purl.obolibrary.org/obo/CHEBI_90415 insulin secretagogue http://purl.obolibrary.org/obo/CHEBI_90414 secretagogue insulin secretagogues http://purl.obolibrary.org/obo/CHEBI_90691 EC 5.3.1.1 (triose-phosphate isomerase) inhibitor http://purl.obolibrary.org/obo/CHEBI_90689 EC 5.3.1.* (intramolecular oxidoreductase interconverting aldoses and ketoses) inhibitor triosephosphate mutase inhibitors http://purl.obolibrary.org/obo/CHEBI_91025 erythropoietin inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor erythropoietin inhibitors http://purl.obolibrary.org/obo/CHEBI_91085 collagen cross-linking inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor collagen cross-linking inhibitors http://purl.obolibrary.org/obo/CHEBI_91139 elastin-laminin receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist elastin-laminin receptor agonists http://purl.obolibrary.org/obo/CHEBI_35197 lumiphore http://purl.obolibrary.org/obo/CHEBI_52215 photochemical role lumiphore http://purl.obolibrary.org/obo/CHEBI_35205 chemical tracer http://purl.obolibrary.org/obo/CHEBI_35204 tracer chemical tracer http://purl.obolibrary.org/obo/CHEBI_35206 isotopic tracer http://purl.obolibrary.org/obo/CHEBI_35204 tracer isotopic tracer http://purl.obolibrary.org/obo/CHEBI_35207 radioactive tracer http://purl.obolibrary.org/obo/CHEBI_35204 tracer radioactive tracer http://purl.obolibrary.org/obo/CHEBI_35208 physical tracer http://purl.obolibrary.org/obo/CHEBI_35204 tracer physical tracer http://purl.obolibrary.org/obo/CHEBI_35209 label http://purl.obolibrary.org/obo/CHEBI_33232 application label http://purl.obolibrary.org/obo/CHEBI_35210 spin label http://purl.obolibrary.org/obo/CHEBI_35209 label spin label http://purl.obolibrary.org/obo/CHEBI_35211 radioactive label http://purl.obolibrary.org/obo/CHEBI_35209 label radioactive label http://purl.obolibrary.org/obo/CHEBI_35226 spin probe http://purl.obolibrary.org/obo/CHEBI_50406 probe spin probe http://purl.obolibrary.org/obo/CHEBI_35231 nuclear fuel http://purl.obolibrary.org/obo/CHEBI_33292 fuel nuclear fuel http://purl.obolibrary.org/obo/CHEBI_35232 radiopharmaceutical http://purl.obolibrary.org/obo/CHEBI_52217 pharmaceutical radiopharmaceuticals http://purl.obolibrary.org/obo/CHEBI_35473 tranquilizing drug http://purl.obolibrary.org/obo/CHEBI_35488 central nervous system depressant tranquillizing agents http://purl.obolibrary.org/obo/CHEBI_35841 uricosuric drug http://purl.obolibrary.org/obo/CHEBI_35846 renal agent uricosuric drugs http://purl.obolibrary.org/obo/CHEBI_35845 gout suppressant http://purl.obolibrary.org/obo/CHEBI_35842 antirheumatic drug gout suppressants http://purl.obolibrary.org/obo/CHEBI_35846 renal agent http://purl.obolibrary.org/obo/CHEBI_23888 drug renal agents http://purl.obolibrary.org/obo/CHEBI_36050 antitreponemal drug http://purl.obolibrary.org/obo/CHEBI_36047 antibacterial drug antitreponemal drugs http://purl.obolibrary.org/obo/CHEBI_36051 antisyphilitic drug http://purl.obolibrary.org/obo/CHEBI_36050 antitreponemal drug antisyphilitics http://purl.obolibrary.org/obo/CHEBI_36053 acaricide drug http://purl.obolibrary.org/obo/CHEBI_35442 antiparasitic agent acaricide drugs http://purl.obolibrary.org/obo/CHEBI_36710 interferon inducer http://purl.obolibrary.org/obo/CHEBI_23888 drug interferon inducers http://purl.obolibrary.org/obo/CHEBI_37957 histaminergic drug http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent histaminergic drugs http://purl.obolibrary.org/obo/CHEBI_38956 ectoparasiticide http://purl.obolibrary.org/obo/CHEBI_35442 antiparasitic agent ectoparasiticides http://purl.obolibrary.org/obo/CHEBI_48540 beta-adrenergic drug http://purl.obolibrary.org/obo/CHEBI_37962 adrenergic agent beta-adrenergic drugs http://purl.obolibrary.org/obo/CHEBI_63046 emulsifier http://purl.obolibrary.org/obo/CHEBI_51086 chemical role emulsifiers http://purl.obolibrary.org/obo/CHEBI_71173 H1-receptor agonist http://purl.obolibrary.org/obo/CHEBI_35678 histamine agonist histamine H1-receptor agonists http://purl.obolibrary.org/obo/CHEBI_76775 EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76760 EC 3.1.* (ester hydrolase) inhibitor EC 3.1.3.* (phosphoric monoester hydrolase) inhibitors http://purl.obolibrary.org/obo/CHEBI_76782 EC 3.4.15.* (peptidyl-dipeptidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_60258 EC 3.4.* (hydrolases acting on peptide bond) inhibitor peptidyl-dipeptidase inhibitors http://purl.obolibrary.org/obo/CHEBI_76808 EC 3.5.2.* (non-peptide cyclic amide C-N hydrolase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76764 EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor non-peptide cyclic amide C-N hydrolase (EC 3.5.2.*) inhibitor http://purl.obolibrary.org/obo/CHEBI_76835 EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76726 EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor (EC 1.1.1.*) inhibitor http://purl.obolibrary.org/obo/CHEBI_76840 EC 1.14.99.* (miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor http://purl.obolibrary.org/obo/CHEBI_76741 EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor miscellaneous oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen (EC 1.14.99.*) inhibitor http://purl.obolibrary.org/obo/CHEBI_76850 EC 1.17.3.* (oxidoreductase acting on CH or CH2 with oxygen as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76744 EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor oxidoreductase acting on CH or CH2 with oxygen as acceptor (EC 1.17.3.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_76852 EC 1.2.1.* (oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76727 EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor oxidoreductase acting on donor aldehyde/oxo group with NAD(+) or NADP(+) as acceptor (EC 1.2.1.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_83741 phospholipid biosynthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role phospholipid biosynthesis inhibitors http://purl.obolibrary.org/obo/CHEBI_91081 purinergic receptor P2X antagonist http://purl.obolibrary.org/obo/CHEBI_91079 purinergic receptor P2 antagonist purinergic receptor P2X antagonists http://purl.obolibrary.org/obo/CHEBI_62609 EC 3.11.1.3 (phosphonopyruvate hydrolase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76883 EC 3.11.1.* (hydrolases acting on C-P bonds of phosphono-acetaldehyde, -acetate, or -pyruvate) inhibitor phosphonopyruvate hydrolase (EC 3.11.1.3) inhibitors http://purl.obolibrary.org/obo/CHEBI_63533 gonadotropin releasing hormone agonist http://purl.obolibrary.org/obo/CHEBI_51060 hormone agonist gonadotropin releasing hormone agonists http://purl.obolibrary.org/obo/CHEBI_77103 EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor http://purl.obolibrary.org/obo/CHEBI_77102 EC 1.3.5.* (oxidoreductase acting on CH-CH of donor with a quinone or related compound as acceptor) inhibitor EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitors http://purl.obolibrary.org/obo/CHEBI_77106 EC 1.10.2.2 (quinol--cytochrome-c reductase) inhibitor http://purl.obolibrary.org/obo/CHEBI_77105 EC 1.10.2.* (oxidoreductase acting on diphenols and related substances as donors with a cytochrome as acceptor) inhibitor quinol--cytochrome-c reductase (EC 1.10.2.2) inhibitors http://purl.obolibrary.org/obo/CHEBI_85384 GABA reuptake inhibitor http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent gamma-aminobutyric acid reuptake inhibitors http://purl.obolibrary.org/obo/CHEBI_91015 corrosion inhibitor http://purl.obolibrary.org/obo/CHEBI_51086 chemical role corrosion inhibitors http://purl.obolibrary.org/obo/CHEBI_64154 H3-receptor agonist http://purl.obolibrary.org/obo/CHEBI_35678 histamine agonist histamine H3-receptor agonists http://purl.obolibrary.org/obo/CHEBI_64155 H4-receptor agonist http://purl.obolibrary.org/obo/CHEBI_35678 histamine agonist H4-receptor agonists http://purl.obolibrary.org/obo/CHEBI_64371 neurotransmitter transporter modulator http://purl.obolibrary.org/obo/CHEBI_38632 membrane transport modulator neurotransmitter transporter modulators http://purl.obolibrary.org/obo/CHEBI_64406 EC 3.4.22.38 (cathepsin K) inhibitor http://purl.obolibrary.org/obo/CHEBI_76796 EC 3.4.22.* (cysteine endopeptidase) inhibitor cathepsin X inhibitors http://purl.obolibrary.org/obo/CHEBI_64411 EC 2.5.1.29 (geranylgeranyl diphosphate synthase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76663 EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor geranylgeranyl diphosphate synthase (EC 2.5.1.29) inhibitor http://purl.obolibrary.org/obo/CHEBI_64696 EC 2.3.1.26 (sterol O-acyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76878 EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor acylcoenzyme A:cholesterol O-acyltransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_64919 EC 2.3.1.20 (diacylglycerol O-acyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76878 EC 2.3.1.* (acyltransferase transferring other than amino-acyl group) inhibitor diacylglycerol O-acyltransferase (EC 2.3.1.20) inhibitor http://purl.obolibrary.org/obo/CHEBI_64920 EC 6.5.1.1 [DNA ligase (ATP)] inhibitor http://purl.obolibrary.org/obo/CHEBI_76827 EC 6.5.1.* (DNA/RNA repair enzymes) inhibitor sealase inhibitors http://purl.obolibrary.org/obo/CHEBI_64943 EC 3.4.21.1 (chymotrypsin) inhibitor http://purl.obolibrary.org/obo/CHEBI_5924 EC 3.4.21.* (serine endopeptidase) inhibitor quimotrase inhibitors http://purl.obolibrary.org/obo/CHEBI_64949 anti-HIV-2 agent http://purl.obolibrary.org/obo/CHEBI_64946 anti-HIV agent anti-HIV-2 agents http://purl.obolibrary.org/obo/CHEBI_64952 anti-HSV agent http://purl.obolibrary.org/obo/CHEBI_22587 antiviral agent anti-human herpes virus agents http://purl.obolibrary.org/obo/CHEBI_64954 anti-HSV-2 agent http://purl.obolibrary.org/obo/CHEBI_64952 anti-HSV agent anti-human herpes virus-II agents http://purl.obolibrary.org/obo/CHEBI_64955 EC 3.2.1.166 (heparanase) inhibitor http://purl.obolibrary.org/obo/CHEBI_52424 EC 3.2.1.* (glycosidase) inhibitor heparan sulfate N-sulfo-D-glucosamine endoglucanase inhibitor http://purl.obolibrary.org/obo/CHEBI_64957 EC 3.4.21.39 (chymase) inhibitor http://purl.obolibrary.org/obo/CHEBI_5924 EC 3.4.21.* (serine endopeptidase) inhibitor skin chymotryptic proteinase inhibitors http://purl.obolibrary.org/obo/CHEBI_65239 EC 3.2.1.114 (mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_52424 EC 3.2.1.* (glycosidase) inhibitor GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase inhibitors http://purl.obolibrary.org/obo/CHEBI_65254 LRH-1 agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist nuclear receptor subfamily 5 group A member 2 agonist http://purl.obolibrary.org/obo/CHEBI_71168 HIV-1 maturation inhibitor http://purl.obolibrary.org/obo/CHEBI_64947 anti-HIV-1 agent HIV-1 maturation inhibitors http://purl.obolibrary.org/obo/CHEBI_72571 pro-angiogenic agent http://purl.obolibrary.org/obo/CHEBI_50926 angiogenesis modulating agent proangiogenic agents http://purl.obolibrary.org/obo/CHEBI_76733 EC 1.6.* (oxidoreductase acting on NADH or NADPH) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor inhibitor of oxidoreductase acting on NADH or NADPH http://purl.obolibrary.org/obo/CHEBI_76795 EC 3.4.22.36 (caspase-1) inhibitor http://purl.obolibrary.org/obo/CHEBI_76796 EC 3.4.22.* (cysteine endopeptidase) inhibitor interleukin 1beta-converting endopeptidase inhibitor http://purl.obolibrary.org/obo/CHEBI_76796 EC 3.4.22.* (cysteine endopeptidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_60258 EC 3.4.* (hydrolases acting on peptide bond) inhibitor cysteine endopeptidase inhibitors http://purl.obolibrary.org/obo/CHEBI_76816 EC 2.7.8.* (transferases for other substituted phosphate groups) inhibitor http://purl.obolibrary.org/obo/CHEBI_76668 EC 2.7.* (P-containing group transferase) inhibitor EC 2.7.8.* inhibitors http://purl.obolibrary.org/obo/CHEBI_76827 EC 6.5.1.* (DNA/RNA repair enzymes) inhibitor http://purl.obolibrary.org/obo/CHEBI_75605 EC 6.5.* (phosphoric ester bond-forming ligase) inhibitor EC 6.5.1.* inhibitors http://purl.obolibrary.org/obo/CHEBI_76869 EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76735 EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD(+) or NADP(+) as acceptor) inhibitors http://purl.obolibrary.org/obo/CHEBI_76940 EC 3.4.21.4 (trypsin) inhibitor http://purl.obolibrary.org/obo/CHEBI_5924 EC 3.4.21.* (serine endopeptidase) inhibitor trypure inhibitors http://purl.obolibrary.org/obo/CHEBI_85425 glycine transporter inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor glycine transporter inhibitors http://purl.obolibrary.org/obo/CHEBI_75298 histamine releasing agent http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role histamine releasing substances http://purl.obolibrary.org/obo/CHEBI_75324 excipient http://purl.obolibrary.org/obo/CHEBI_33232 application fillers http://purl.obolibrary.org/obo/CHEBI_75416 EC 6.1.1.* (ligases forming aminoacyl tRNA and related compounds) inhibitor http://purl.obolibrary.org/obo/CHEBI_76706 EC 6.1.* (C-O bond-forming ligase) inhibitor tRNA synthetase inhibitors http://purl.obolibrary.org/obo/CHEBI_75429 EC 1.4.4.2 [glycine dehydrogenase (aminomethyl-transferring)] inhibitor http://purl.obolibrary.org/obo/CHEBI_76862 EC 1.4.4.* (oxidoreductase acting on donor CH-NH2 group, a disulfide as acceptor) inhibitor glycine dehydrogenase (aminomethyl-transferring) (EC 1.4.4.2) inhibitors http://purl.obolibrary.org/obo/CHEBI_75495 EC 6.1.1.11 (serine--tRNA ligase) inhibitor http://purl.obolibrary.org/obo/CHEBI_75416 EC 6.1.1.* (ligases forming aminoacyl tRNA and related compounds) inhibitor seryl-transfer ribonucleic acid synthetase inhibitors http://purl.obolibrary.org/obo/CHEBI_75595 EC 5.1.1.1 (alanine racemase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76828 EC 5.1.1.* (racemases acting on amino acids and derivatives) inhibitor alanine racemase inhibitors http://purl.obolibrary.org/obo/CHEBI_75596 EC 5.* (isomerase) inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor isomerase inhibitors http://purl.obolibrary.org/obo/CHEBI_75598 EC 6.3.2.4 (D-alanine--D-alanine ligase) inhibitor http://purl.obolibrary.org/obo/CHEBI_59105 EC 6.3.2.* (acid--D-amino-acid ligase) inhibitor D-alanine--D-alanine ligase (EC 6.3.2.4) inhibitors http://purl.obolibrary.org/obo/CHEBI_75603 EC 6.* (ligase) inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor ligase inhibitors http://purl.obolibrary.org/obo/CHEBI_75604 EC 6.4.* (C-C bond-forming ligase) inhibitor http://purl.obolibrary.org/obo/CHEBI_75603 EC 6.* (ligase) inhibitor EC 6.4.*.* inhibitors http://purl.obolibrary.org/obo/CHEBI_75605 EC 6.5.* (phosphoric ester bond-forming ligase) inhibitor http://purl.obolibrary.org/obo/CHEBI_75603 EC 6.* (ligase) inhibitor EC 6.5.* (phosphoric ester bond-forming ligase) inhibitors http://purl.obolibrary.org/obo/CHEBI_75787 prokaryotic metabolite http://purl.obolibrary.org/obo/CHEBI_25212 metabolite prokaryotic metabolites http://purl.obolibrary.org/obo/CHEBI_75835 anti-anaemic agent http://purl.obolibrary.org/obo/CHEBI_33232 application antianemia drugs http://purl.obolibrary.org/obo/CHEBI_75968 EC 6.3.2.19 (ubiquitin--protein ligase) inhibitor http://purl.obolibrary.org/obo/CHEBI_59105 EC 6.3.2.* (acid--D-amino-acid ligase) inhibitor ubiquitin:protein-lysine N-ligase (AMP-forming) inhibitors http://purl.obolibrary.org/obo/CHEBI_76022 soluble guanylate cyclase activator http://purl.obolibrary.org/obo/CHEBI_35224 effector soluble guanylyl cyclase activators http://purl.obolibrary.org/obo/CHEBI_76414 propellant http://purl.obolibrary.org/obo/CHEBI_33232 application propellants http://purl.obolibrary.org/obo/CHEBI_76531 odorant receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist odorant receptor blockers http://purl.obolibrary.org/obo/CHEBI_76655 EC 2.1.* (C1-transferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_71300 EC 2.* (transferase) inhibitor one-carbon-containing group transferase inhibitors http://purl.obolibrary.org/obo/CHEBI_76660 EC 2.2.* (aldehyde or ketone transferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_71300 EC 2.* (transferase) inhibitor EC 2.2.* (aldehyde or ketone transferase) inhibitors http://purl.obolibrary.org/obo/CHEBI_76661 EC 2.3.* (acyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_71300 EC 2.* (transferase) inhibitor acyltransferase inhibitors http://purl.obolibrary.org/obo/CHEBI_76665 EC 2.6.* (nitrogenous group transferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_71300 EC 2.* (transferase) inhibitor nitrogenous group transferase (EC 2.6.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_76676 EC 2.8.* (S-containing group transferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_71300 EC 2.* (transferase) inhibitor EC 2.8.* (S-containing group transferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76677 EC 2.9.* (Se-containing group transferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_71300 EC 2.* (transferase) inhibitor selenium-containing group transferase (EC 2.9.*) inhibitor http://purl.obolibrary.org/obo/CHEBI_76681 EC 2.10.* (Mo- or W-containing group transferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_71300 EC 2.* (transferase) inhibitor EC 2.10.* (Mo- or W-containing group transferase) inhibitors http://purl.obolibrary.org/obo/CHEBI_76692 EC 5.1.* (racemase/epimerase) inhibitor http://purl.obolibrary.org/obo/CHEBI_75596 EC 5.* (isomerase) inhibitor racemase/epimerase inhibitors http://purl.obolibrary.org/obo/CHEBI_76693 EC 5.2.* (cis-trans-isomerase) inhibitor http://purl.obolibrary.org/obo/CHEBI_75596 EC 5.* (isomerase) inhibitor cis-trans-isomerase inhibitors http://purl.obolibrary.org/obo/CHEBI_76694 EC 5.3.* (intramolecular oxidoreductase) inhibitor http://purl.obolibrary.org/obo/CHEBI_75596 EC 5.* (isomerase) inhibitor EC 5.3.* (intramolecular oxidoreductase) inhibitors http://purl.obolibrary.org/obo/CHEBI_76696 EC 5.5.* (intramolecular lyase) inhibitor http://purl.obolibrary.org/obo/CHEBI_75596 EC 5.* (isomerase) inhibitor intramolecular lyase inhibitors http://purl.obolibrary.org/obo/CHEBI_76697 EC 5.99.* (other isomerases) inhibitor http://purl.obolibrary.org/obo/CHEBI_75596 EC 5.* (isomerase) inhibitor EC 5.99.* inhibitors http://purl.obolibrary.org/obo/CHEBI_76706 EC 6.1.* (C-O bond-forming ligase) inhibitor http://purl.obolibrary.org/obo/CHEBI_75603 EC 6.* (ligase) inhibitor EC 6.1.* inhibitors http://purl.obolibrary.org/obo/CHEBI_76707 EC 6.2.* (C-S bond-forming ligase) inhibitor http://purl.obolibrary.org/obo/CHEBI_75603 EC 6.* (ligase) inhibitor EC 6.2.* inhibitors http://purl.obolibrary.org/obo/CHEBI_76708 EC 6.6.* (N-metal bond-forming ligase) inhibitor http://purl.obolibrary.org/obo/CHEBI_75603 EC 6.* (ligase) inhibitor N-metal bond-forming ligase inhibitors http://purl.obolibrary.org/obo/CHEBI_76710 EC 4.* (lyase) inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor lyase inhibitors http://purl.obolibrary.org/obo/CHEBI_76711 EC 4.1.* (C-C lyase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76710 EC 4.* (lyase) inhibitor EC 4.1.* inhibitors http://purl.obolibrary.org/obo/CHEBI_76712 EC 4.2.* (C-O lyase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76710 EC 4.* (lyase) inhibitor EC 4.2.* inhibitors http://purl.obolibrary.org/obo/CHEBI_76713 EC 4.3.* (C-N lyase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76710 EC 4.* (lyase) inhibitor EC 4.3.* inhibitors http://purl.obolibrary.org/obo/CHEBI_76714 EC 4.4.* (C-S lyase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76710 EC 4.* (lyase) inhibitor EC 4.4.* inhibitors http://purl.obolibrary.org/obo/CHEBI_76715 EC 4.5.* (C-halide lyase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76710 EC 4.* (lyase) inhibitor EC 4.5.* inhibitors http://purl.obolibrary.org/obo/CHEBI_76716 EC 4.6.* (P-O lyase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76710 EC 4.* (lyase) inhibitor P-O lyase inhibitors http://purl.obolibrary.org/obo/CHEBI_76717 EC 4.7.* (C-P lyase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76710 EC 4.* (lyase) inhibitor EC 4.7.* inhibitors http://purl.obolibrary.org/obo/CHEBI_76718 EC 4.99.* (miscellaneous lyase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76710 EC 4.* (lyase) inhibitor other lyase (EC 4.99.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor oxidoreductase inhibitors http://purl.obolibrary.org/obo/CHEBI_76726 EC 1.1.* (oxidoreductase acting on donor CH-OH group) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor inhibitors of oxidoreductase acting on CH-OH group of donors http://purl.obolibrary.org/obo/CHEBI_76727 EC 1.2.* (oxidoreductase acting on donor aldehyde/oxo group) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor EC 1.2.* (oxidoreductase acting on donor aldehyde or oxo group) inhibitors http://purl.obolibrary.org/obo/CHEBI_76729 EC 1.3.* (oxidoreductase acting on donor CH-CH group) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor inhibitors of oxidoreductase acting on CH-CH group of donor http://purl.obolibrary.org/obo/CHEBI_76731 EC 1.5.* (oxidoreductase acting on donor CH-NH group) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor inhibitor of oxidoreductase acting on CH-NH group of donor http://purl.obolibrary.org/obo/CHEBI_76734 EC 1.7.* (oxidoreductase acting on other nitrogenous compounds as donors) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor inhibitor of oxidoreductase acting on other nitrogenous compounds as donors (EC 1.7.*) http://purl.obolibrary.org/obo/CHEBI_76735 EC 1.8.* (oxidoreductase acting on sulfur group of donors) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor oxidoreductase acting on a sulfur group of donors (EC 1.8.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_76736 EC 1.9.* (oxidoreductase acting on donor heme group) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor EC 1.9.* (oxidoreductase acting on a heme group of donors) inhibitors http://purl.obolibrary.org/obo/CHEBI_76737 EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor inhibitor of an oxidoreductase acting on diphenols and related substances as donor http://purl.obolibrary.org/obo/CHEBI_76738 EC 1.11.* (oxidoreductase acting on peroxide as donors) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor EC 1.11.* (oxidoreductases acting on peroxide as donors) inhibitors http://purl.obolibrary.org/obo/CHEBI_76739 EC 1.12.* (oxidoreductase acting on hydrogen as donors) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor oxidoreductase acting on hydrogen as donors inhibitor http://purl.obolibrary.org/obo/CHEBI_76740 EC 1.13.* [oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases)] inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor oxidoreductase acting on single donors with incorporation of molecular oxygen (oxygenases) inhibitor http://purl.obolibrary.org/obo/CHEBI_76741 EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitors http://purl.obolibrary.org/obo/CHEBI_76743 EC 1.16.* (oxidoreductase oxidising metal ions) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor EC 1.16.* (oxidoreductase oxidizing metal ions) inhibitors http://purl.obolibrary.org/obo/CHEBI_76744 EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor EC 1.17.* (oxidoreductase acting on CH or CH2) inhibitors http://purl.obolibrary.org/obo/CHEBI_76745 EC 1.18.* (oxidoreductase acting on Fe-S proteins as donors) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor inhibitor of oxidoreductase acting on Fe-S proteins as donors http://purl.obolibrary.org/obo/CHEBI_76746 EC 1.19.* (oxidoreductase acting on reduced flavodoxin as donor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor EC 1.19.* (oxidoreductase acting on reduced flavodoxin as donor) inhibitors http://purl.obolibrary.org/obo/CHEBI_76747 EC 1.20.* (oxidoreductase acting on P or As in donors) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor EC 1.20.* (oxidoreductase acting on P or As in donors) inhibitors http://purl.obolibrary.org/obo/CHEBI_76748 EC 1.21.* (oxidoreductase acting on X-H and Y-H to form an X-Y bond) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor EC 1.21.* (oxidoreductase acting on X-H and Y-H to form an X-Y bond) inhibitors http://purl.obolibrary.org/obo/CHEBI_76750 EC 1.22* (oxidoreductase acting on halogen in donors) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor EC 1.22* (oxidoreductase acting on halogen in donors) inhibitors http://purl.obolibrary.org/obo/CHEBI_76752 EC 1.23.* (oxidoreductase acting on C-O-C group as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor oxidoreductase acting on C-O-C group as acceptor (EC 1.23.*) inhibitors http://purl.obolibrary.org/obo/CHEBI_76753 EC 1.97.* (other oxidoreductase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor inhibitor of miscellaneous oxidoreductase (EC 1.97.*) http://purl.obolibrary.org/obo/CHEBI_76755 EC 1.98.* (enzymes using H2 as reductant) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor EC 1.98.* (enzymes using H2 as reductant) inhibitors http://purl.obolibrary.org/obo/CHEBI_76757 EC 1.99.* (other oxidoreductases using O2 as oxidant) inhibitor http://purl.obolibrary.org/obo/CHEBI_76725 EC 1.* (oxidoreductase) inhibitor EC 1.99.* (other oxidoreductases using O2 as oxidant) inhibitors http://purl.obolibrary.org/obo/CHEBI_76762 EC 3.3.* (ether hydrolase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76759 EC 3.* (hydrolase) inhibitor EC 3.3.* (hydrolase acting on ether bond) inhibitor http://purl.obolibrary.org/obo/CHEBI_76764 EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor http://purl.obolibrary.org/obo/CHEBI_76759 EC 3.* (hydrolase) inhibitor EC 3.5.* (hydrolases acting on C-N bonds, other than peptide bonds) inhibitors http://purl.obolibrary.org/obo/CHEBI_76766 EC 3.7.* (hydrolases acting on C-C bonds) inhibitor http://purl.obolibrary.org/obo/CHEBI_76759 EC 3.* (hydrolase) inhibitor EC 3.7.* (hydrolases acting on carbon-carbon bonds) inhibitors http://purl.obolibrary.org/obo/CHEBI_76767 EC 3.8.* (hydrolases acting on halide bonds) inhibitor http://purl.obolibrary.org/obo/CHEBI_76759 EC 3.* (hydrolase) inhibitor EC 3.8.* (hydrolases acting on halide bonds) inhibitors http://purl.obolibrary.org/obo/CHEBI_76768 EC 3.9.* (hydrolases acting on P-N bonds) inhibitor http://purl.obolibrary.org/obo/CHEBI_76759 EC 3.* (hydrolase) inhibitor inhibitors of hydrolases acting on phosphorus-nitrogen bonds http://purl.obolibrary.org/obo/CHEBI_76769 EC 3.10.* (hydrolases acting on S-N bonds) inhibitor http://purl.obolibrary.org/obo/CHEBI_76759 EC 3.* (hydrolase) inhibitor inhibitors of hydrolases acting on sulfur-nitrogen bonds (EC 3.10.*) http://purl.obolibrary.org/obo/CHEBI_76770 EC 3.11.* (hydrolases acting on C-P bonds) inhibitor http://purl.obolibrary.org/obo/CHEBI_76759 EC 3.* (hydrolase) inhibitor EC 3.11.* (hydrolases acting on C-P bonds) inhibitors http://purl.obolibrary.org/obo/CHEBI_76771 EC 3.12.* (hydrolases acting on S-S bonds) inhibitor http://purl.obolibrary.org/obo/CHEBI_76759 EC 3.* (hydrolase) inhibitor hydrolases acting on sulfur-sulfur bonds inhibitors http://purl.obolibrary.org/obo/CHEBI_76772 EC 3.13.* (hydrolases acting on C-S bonds) inhibitor http://purl.obolibrary.org/obo/CHEBI_76759 EC 3.* (hydrolase) inhibitor hydrolases acting on carbon-sulfur bonds inhibitors http://purl.obolibrary.org/obo/CHEBI_76828 EC 5.1.1.* (racemases acting on amino acids and derivatives) inhibitor http://purl.obolibrary.org/obo/CHEBI_76692 EC 5.1.* (racemase/epimerase) inhibitor inhibitor of racemases acting on amino acids and derivatives http://purl.obolibrary.org/obo/CHEBI_76834 EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_71300 EC 2.* (transferase) inhibitor EC 2.5.* (non-methyl-alkyl or aryl transferase) inhibitors http://purl.obolibrary.org/obo/CHEBI_76843 EC 1.14.15.* (oxidoreductase acting on paired donors, with reduced Fe-S protein as one donor, incorporating 1 O atom) inhibitor http://purl.obolibrary.org/obo/CHEBI_76741 EC 1.14.* (oxidoreductase acting on paired donors, with incorporation or reduction of molecular oxygen) inhibitor oxidoreductase acting on paired donors, with reduced iron-sulfur protein as one donor, incorporating 1 atom of oxygen (EC 1.14.15.*) inhibitor http://purl.obolibrary.org/obo/CHEBI_76862 EC 1.4.4.* (oxidoreductase acting on donor CH-NH2 group, a disulfide as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76730 EC 1.4.* (oxidoreductase acting on donor CH-NH2 group) inhibitor oxidoreductase acting on donor CH-NH2 group, a disulfide as acceptor (EC 1.4.4.*) inhibitor http://purl.obolibrary.org/obo/CHEBI_76916 hyperglycemic agent http://purl.obolibrary.org/obo/CHEBI_23888 drug hyperglycemic agents http://purl.obolibrary.org/obo/CHEBI_76920 EC 1.1.3.9 (galactose oxidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76836 EC 1.1.3.* (oxidoreductase acting on donor CH-OH group, oxygen as acceptor) inhibitor galactose oxidase inhibitors http://purl.obolibrary.org/obo/CHEBI_76938 EC 3.6.4.* (hydrolases acting on ATP; involved in cellular and subcellular movement) inhibitor http://purl.obolibrary.org/obo/CHEBI_73216 EC 3.6.* (hydrolases acting on acid anhydrides) inhibitor hydrolases acting on ATP; involved in cellular and subcellular movement (EC 3.6.4.*) inhibitor http://purl.obolibrary.org/obo/CHEBI_76977 corticotropin-releasing factor receptor antagonist http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist CRF antagonists http://purl.obolibrary.org/obo/CHEBI_76998 aryl hydrocarbon receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist aryl hydrocarbon receptor antagonists http://purl.obolibrary.org/obo/CHEBI_77019 EC 1.10.99.* (oxidoreductases acting on diphenols and related substances as donors, other acceptors) inhibitor http://purl.obolibrary.org/obo/CHEBI_76737 EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor oxidoreductases acting on diphenols and related substances as donors, other acceptors (EC 1.10.99.*) inhibitor http://purl.obolibrary.org/obo/CHEBI_77022 EC 2.3.3.* (acyltransferase converting acyl to alkyl group on transfer) inhibitor http://purl.obolibrary.org/obo/CHEBI_76661 EC 2.3.* (acyltransferase) inhibitor acyltransferase converting acyl to alkyl group on transfer (EC 2.3.3.*) inhibitor http://purl.obolibrary.org/obo/CHEBI_83609 steatosis inducing agent http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role steatosis inducing drugs http://purl.obolibrary.org/obo/CHEBI_83612 hepatic steatosis inducing agent http://purl.obolibrary.org/obo/CHEBI_83609 steatosis inducing agent hepatic steatosis inducing drugs http://purl.obolibrary.org/obo/CHEBI_84297 EC 3.4.21.64 (peptidase K) inhibitor http://purl.obolibrary.org/obo/CHEBI_5924 EC 3.4.21.* (serine endopeptidase) inhibitor proteinase K inhibitors http://purl.obolibrary.org/obo/CHEBI_84803 EC 2.7.4.* (phosphotransferases with a phosphate group as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76668 EC 2.7.* (P-containing group transferase) inhibitor EC 2.7.4.* inhibitors http://purl.obolibrary.org/obo/CHEBI_85011 EC 2.6.1.19 (glutamine--fructose-6-phosphate transaminase (isomerizing)) inhibitor http://purl.obolibrary.org/obo/CHEBI_76879 EC 2.6.1.* (transaminase) inhibitor L-glutamine:D-fructose-6-phosphate isomerase (deaminating) inhibitors http://purl.obolibrary.org/obo/CHEBI_85012 thrombopoietin receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist thrombopoietin receptor agonists http://purl.obolibrary.org/obo/CHEBI_85048 EC 1.10.3.* (oxidoreductase acting on diphenols and related substances as donors with oxygen as acceptor) inhibitor http://purl.obolibrary.org/obo/CHEBI_76737 EC 1.10.* (oxidoreductase acting on diphenols and related substances as donors) inhibitor EC 1.10.3.* (oxidoreductase acting on diphenols and related substances as donors with oxygen as acceptor) inhibitors http://purl.obolibrary.org/obo/CHEBI_85113 EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76812 EC 2.7.11.* (protein-serine/threonine kinase) inhibitor ATP:protein phosphotransferase (cGMP-dependent) inhibitors http://purl.obolibrary.org/obo/CHEBI_85424 glycine transporter 2 inhibitor http://purl.obolibrary.org/obo/CHEBI_85425 glycine transporter inhibitor glycine transporter 2 inhibitors http://purl.obolibrary.org/obo/CHEBI_90753 antidote to organophosphate poisoning http://purl.obolibrary.org/obo/CHEBI_50247 antidote antidote to acetylcholinesterase inhibitor poisoning http://purl.obolibrary.org/obo/CLO_0001008 697 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 697 http://purl.obolibrary.org/obo/CLO_0001230 HEK293 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 HEK-293 http://purl.obolibrary.org/obo/CLO_0001235 293T/17 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 293T/17 http://purl.obolibrary.org/obo/CLO_0001601 A549 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 A549 http://purl.obolibrary.org/obo/CLO_0001654 ACHN 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 ACHN http://purl.obolibrary.org/obo/CLO_0001716 AML12 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 AML12 http://purl.obolibrary.org/obo/CLO_0001842 BA/F3 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 BA/F3 http://purl.obolibrary.org/obo/CLO_0002044 BT-549 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 BT-549 http://purl.obolibrary.org/obo/CLO_0002115 C-33 A 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 C-33 A http://purl.obolibrary.org/obo/CLO_0002175 CAKI-1 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 CAKI-1 http://purl.obolibrary.org/obo/CLO_0002176 Caki-1 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 Caki-1 http://purl.obolibrary.org/obo/CLO_0002191 Calu-1 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 Calu-1 http://purl.obolibrary.org/obo/CLO_0002334 CCRF-CEM 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 CCRF-CEM http://purl.obolibrary.org/obo/CLO_0002420 CHL-1 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 CHL-1 http://purl.obolibrary.org/obo/CLO_0002421 CHO 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 中国仓鼠卵巢细胞 http://purl.obolibrary.org/obo/CLO_0002462 CHO-K1 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 CHO-K1 http://purl.obolibrary.org/obo/CLO_0002544 COLO 205 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 COLO 205 http://purl.obolibrary.org/obo/CLO_0002597 COS-7 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 COS-7 http://purl.obolibrary.org/obo/CLO_0002785 DLD-1 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 DLD-1 http://purl.obolibrary.org/obo/CLO_0002840 DU 145 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 DU 145 http://purl.obolibrary.org/obo/CLO_0003603 H-4-II-E 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 H-4-II-E http://purl.obolibrary.org/obo/CLO_0003610 H69AR cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 H69AR http://purl.obolibrary.org/obo/CLO_0003665 HCT 116 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 HCT-116 http://purl.obolibrary.org/obo/CLO_0003679 HEL 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 HEL http://purl.obolibrary.org/obo/CLO_0003684 HeLa 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 HeLa http://purl.obolibrary.org/obo/CLO_0003704 Hep G2 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 HepG2 http://purl.obolibrary.org/obo/CLO_0003775 HL-60 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 HL-60 http://purl.obolibrary.org/obo/CLO_0004009 Hs 578T 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 Hs 578T http://purl.obolibrary.org/obo/CLO_0004276 HT-1080 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 HT-1080 http://purl.obolibrary.org/obo/CLO_0004283 HT-29 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 HT-29 http://purl.obolibrary.org/obo/CLO_0004307 HUV-EC-C 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 HUVEC http://purl.obolibrary.org/obo/CLO_0004342 IEC-6 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 IEC-6 http://purl.obolibrary.org/obo/NCBITaxon_1422 Geobacillus stearothermophilus http://www.bioassayontology.org/bao#BAO_0000364 bacterium Bacillus thermoliquefaciens http://purl.obolibrary.org/obo/NCBITaxon_5691 Trypanosoma brucei http://www.bioassayontology.org/bao#BAO_0000662 protozoan Trypanosoma brucei subgroup http://purl.obolibrary.org/obo/NCBITaxon_373153 Streptococcus pneumoniae D39 http://www.bioassayontology.org/bao#BAO_0000364 bacterium Streptococcus pneumoniae strain D39 http://www.bioassayontology.org/bao#BAO_0002438 gene knockdown by siRNA transfection http://www.bioassayontology.org/bao#BAO_0002434 gene knockdown by RNA interference siRNA knockdown http://purl.obolibrary.org/obo/NCBITaxon_10141 Cavia porcellus http://www.bioassayontology.org/bao#BAO_0000362 mammalian Cavia cobaya http://purl.obolibrary.org/obo/NCBITaxon_1351 Enterococcus faecalis http://www.bioassayontology.org/bao#BAO_0000364 bacterium Streptococcus liquefaciens http://purl.obolibrary.org/obo/NCBITaxon_208964 Pseudomonas aeruginosa PAO1 http://www.bioassayontology.org/bao#BAO_0000364 bacterium Pseudomonas sp. PAO1 http://purl.obolibrary.org/obo/NCBITaxon_39947 Oryza sativa Japonica Group http://www.bioassayontology.org/bao#BAO_0000605 plant Oryza sativa subsp. japonica http://purl.obolibrary.org/obo/NCBITaxon_562 Escherichia coli http://www.bioassayontology.org/bao#BAO_0000364 bacterium E. coli http://purl.obolibrary.org/obo/NCBITaxon_5664 Leishmania major http://www.bioassayontology.org/bao#BAO_0000518 non-mammalian Leishmania tropica major http://purl.obolibrary.org/obo/NCBITaxon_573 Klebsiella pneumoniae http://www.bioassayontology.org/bao#BAO_0000364 bacterium 'Klebsiella aerogenes' (Kruse) Taylor et al. 1956 http://purl.obolibrary.org/obo/NCBITaxon_630 Yersinia enterocolitica http://www.bioassayontology.org/bao#BAO_0000364 bacterium Bacterium enterocoliticum http://purl.obolibrary.org/obo/NCBITaxon_8355 Xenopus laevis http://www.bioassayontology.org/bao#BAO_0000518 non-mammalian platanna http://purl.obolibrary.org/obo/NCBITaxon_90371 Salmonella enterica subsp. enterica serovar Typhimurium http://www.bioassayontology.org/bao#BAO_0000364 bacterium Salmonella typhimurium http://purl.obolibrary.org/obo/NCBITaxon_9615 Canis lupus familiaris http://www.bioassayontology.org/bao#BAO_0000362 mammalian Canis familiaris http://purl.obolibrary.org/obo/NCBITaxon_9796 Equus caballus http://www.bioassayontology.org/bao#BAO_0000362 mammalian Equus przewalskii forma caballus http://purl.obolibrary.org/obo/NCBITaxon_9823 Sus scrofa http://www.bioassayontology.org/bao#BAO_0000362 mammalian wild boar http://purl.obolibrary.org/obo/CLO_0007043 JURKAT 细胞 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 JURKAT http://purl.obolibrary.org/obo/NCBITaxon_11269 Marburg marburgvirus http://www.bioassayontology.org/bao#BAO_0000232 virus Marburg virus MBG http://purl.obolibrary.org/obo/NCBITaxon_1245 Leuconostoc mesenteroides http://www.bioassayontology.org/bao#BAO_0000364 bacterium Betacoccus arabinosaceus http://purl.obolibrary.org/obo/NCBITaxon_669 Vibrio harveyi http://www.bioassayontology.org/bao#BAO_0000364 bacterium Vibrio trachuri http://purl.obolibrary.org/obo/NCBITaxon_90370 Salmonella enterica subsp. enterica serovar Typhi http://www.bioassayontology.org/bao#BAO_0000364 bacterium Salmonella typhi http://purl.obolibrary.org/obo/NCBITaxon_1710587 Photuris pensylvanica http://www.bioassayontology.org/bao#BAO_0000511 invertebrate Pennsylania firefly http://purl.obolibrary.org/obo/NCBITaxon_6289 Haemonchus contortus http://www.bioassayontology.org/bao#BAO_0000511 invertebrate red stomach worm http://purl.obolibrary.org/obo/NCBITaxon_7054 Photinus pyralis http://www.bioassayontology.org/bao#BAO_0000511 invertebrate common eastern firefly http://purl.obolibrary.org/obo/CHEBI_136984 EC 4.4.1.14 (1-aminocyclopropane-1-carboxylate synthase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76831 EC 4.4.1.* (C-S lyase) inhibitor 1-aminocyclopropane-1-carboxylate synthetase inhibitor http://purl.obolibrary.org/obo/CHEBI_137114 bromodomain-containing protein 4 inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role bromodomain-containing protein 4 inhibitors http://purl.obolibrary.org/obo/CHEBI_137123 EC 2.7.11.30 (receptor protein serine/threonine kinase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76812 EC 2.7.11.* (protein-serine/threonine kinase) inhibitor receptor type I serine/threonine protein kinase inhibitor http://www.bioassayontology.org/bao#BAO_0001060 guanosine diphosphate http://www.bioassayontology.org/bao#BAO_0002010 nucleotide GDP http://www.bioassayontology.org/bao#BAO_0002437 gene knockdown by shRNA transfection http://www.bioassayontology.org/bao#BAO_0002434 gene knockdown by RNA interference shRNA knockdown http://www.bioassayontology.org/bao#BAO_0000776 Adenosine triphosphate http://www.bioassayontology.org/bao#BAO_0002010 nucleotide ATP http://www.bioassayontology.org/bao#BAO_0030003 Retinoblastoma-associated protein http://www.bioassayontology.org/bao#BAO_0000175 protein Retinoblastoma protein http://purl.obolibrary.org/obo/CHEBI_137079 eukaryotic initiation factor 4F inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role eukaryotic initiation factor 4F inhibitors http://purl.obolibrary.org/obo/NCBITaxon_5207 Cryptococcus neoformans http://www.bioassayontology.org/bao#BAO_0000418 fungi Torulopsis neoformans http://purl.obolibrary.org/obo/NCBITaxon_5476 Candida albicans http://www.bioassayontology.org/bao#BAO_0000553 multicellular fungi Syringospora albicans http://purl.obolibrary.org/obo/NCBITaxon_6100 Aequorea victoria http://www.bioassayontology.org/bao#BAO_0000511 invertebrate Mesonema victoria http://purl.obolibrary.org/obo/NCBITaxon_6192 Fasciola hepatica http://www.bioassayontology.org/bao#BAO_0000511 invertebrate liver fluke http://purl.obolibrary.org/obo/NCBITaxon_633 Yersinia pseudotuberculosis http://www.bioassayontology.org/bao#BAO_0000364 bacterium Pasteurella lymphangitidis http://www.bioassayontology.org/bao#BAO_0000012 phosphate buffered saline http://www.bioassayontology.org/bao#BAO_0003043 molecular entity PBS http://www.bioassayontology.org/bao#BAO_0000119 induced pluripotent stem cell http://purl.obolibrary.org/obo/CLO_0000001 细胞系细胞 iPSC http://www.bioassayontology.org/bao#BAO_0000271 Interferon gamma http://www.bioassayontology.org/bao#BAO_0000369 secreted IFN-gamma http://www.bioassayontology.org/bao#BAO_0000693 HEPES http://www.bioassayontology.org/bao#BAO_0003043 molecular entity 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid http://www.bioassayontology.org/bao#BAO_0000694 tris http://www.bioassayontology.org/bao#BAO_0003043 molecular entity Tris (hydroxymethyl) aminomethane http://www.bioassayontology.org/bao#BAO_0000764 MurNAc-L-Ala-gamma-D-Glu-mDAP http://www.bioassayontology.org/bao#BAO_0000325 peptide M-TriDAP http://www.bioassayontology.org/bao#BAO_0000772 triiodothyronine http://www.bioassayontology.org/bao#BAO_0003043 molecular entity T3 http://www.bioassayontology.org/bao#BAO_0000774 Z-Leu-Leu-Leu-al http://www.bioassayontology.org/bao#BAO_0000325 peptide MG132 http://www.bioassayontology.org/bao#BAO_0000777 CDP-ME http://www.bioassayontology.org/bao#BAO_0003043 molecular entity 4-diphosphocytidyl-2-C-methyl-D-erythritol http://www.bioassayontology.org/bao#BAO_0000779 Creatine kinase http://www.bioassayontology.org/bao#BAO_0000294 kinase creatine phosphokinase http://www.bioassayontology.org/bao#BAO_0000886 inositol-1-phosphate http://www.bioassayontology.org/bao#BAO_0003043 molecular entity inositol monophosphate http://www.bioassayontology.org/bao#BAO_0000919 G alpha O-Alexa Fluor 488 http://www.bioassayontology.org/bao#BAO_0000368 G protein guanine nucleotide-binding protein G(o) subunit alpha isoform a-Alexa Fluor 488 http://www.bioassayontology.org/bao#BAO_0000972 NBD C6-HPC http://www.bioassayontology.org/bao#BAO_0003043 molecular entity 2-(6-(7-Nitrobenz-2-Oxa-1,3-Diazol-4-yl)amino)Hexanoyl-1-Hexadecanoyl-sn-Glycero-3-Phosphocholine (NBD C6-HPC) http://www.bioassayontology.org/bao#BAO_0001015 the structural genomics consortium http://www.bioassayontology.org/bao#BAO_0000709 research institute SGC Oxford http://www.bioassayontology.org/bao#BAO_0002005 kinase activity assay http://www.bioassayontology.org/bao#BAO_0002795 transferase activity assay kinase screen http://www.bioassayontology.org/bao#BAO_0002016 lipopolysaccharide http://www.bioassayontology.org/bao#BAO_0002015 carbohydrate LPS http://www.bioassayontology.org/bao#BAO_0002043 apoptosis assay http://www.bioassayontology.org/bao#BAO_0002993 cytotoxicity assay programmed cell death http://www.bioassayontology.org/bao#BAO_0002066 Serum albumin http://www.bioassayontology.org/bao#BAO_0000369 secreted Bovine serum albumin http://www.bioassayontology.org/bao#BAO_0002068 calculated value http://www.bioassayontology.org/bao#BAO_0002067 assay readout type calculated measurement http://www.bioassayontology.org/bao#BAO_0002070 measured value http://www.bioassayontology.org/bao#BAO_0002067 assay readout type raw measurement http://www.bioassayontology.org/bao#BAO_0002182 pharmacokinetic assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay pharmacokinetic study http://www.bioassayontology.org/bao#BAO_0002183 pharmacodynamic assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay http://www.bioassayontology.org/bao#BAO_0002184 QT interval assay http://www.bioassayontology.org/bao#BAO_0002533 safety pharmacology assay QT interval study http://www.bioassayontology.org/bao#BAO_0002188 drug interaction assay http://www.bioassayontology.org/bao#BAO_0002533 safety pharmacology assay drug-drug interactions http://www.bioassayontology.org/bao#BAO_0002499 parallel artificial membrane permeation assay http://www.bioassayontology.org/bao#BAO_0002485 reconstitution method Parallel artificial membrane permeability assay http://www.bioassayontology.org/bao#BAO_0002530 bioavailability assay http://www.bioassayontology.org/bao#BAO_0002182 pharmacokinetic assay bioavailability study http://www.bioassayontology.org/bao#BAO_0002532 tissue distribution assay http://www.bioassayontology.org/bao#BAO_0002182 pharmacokinetic assay tissue exposure http://www.bioassayontology.org/bao#BAO_0002533 safety pharmacology assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay safety pharmacology assay http://www.bioassayontology.org/bao#BAO_0002537 ethyleneglycol-bis(β-aminoethyl)-N,N,N′,N′-tetraacetic acid http://www.bioassayontology.org/bao#BAO_0003043 molecular entity EGTA http://www.bioassayontology.org/bao#BAO_0002538 ethylenediaminetetraacetic acid http://www.bioassayontology.org/bao#BAO_0003043 molecular entity EDTA http://www.bioassayontology.org/bao#BAO_0002649 co-culture http://www.bioassayontology.org/bao#BAO_0002647 cell culture method co-culture assay http://www.bioassayontology.org/bao#BAO_0002757 Cyclic guanosine monophosphate http://www.bioassayontology.org/bao#BAO_0002010 nucleotide cGMP http://www.bioassayontology.org/bao#BAO_0002781 inositol 1,4,5-trisphosphate http://www.bioassayontology.org/bao#BAO_0003043 molecular entity inositol trisphosphate http://www.bioassayontology.org/bao#BAO_0002805 cell proliferation assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics proliferation of human breast tumor cells http://www.bioassayontology.org/bao#BAO_0002993 cytotoxicity assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics in vitro cytotoxic activity http://www.bioassayontology.org/bao#BAO_0003033 mobility shift assessment method http://www.bioassayontology.org/bao#BAO_0000123 binding assessment method mobility shift isolated enzyme assay http://www.bioassayontology.org/bao#BAO_0003053 PIPES http://www.bioassayontology.org/bao#BAO_0003043 molecular entity piperazine-N,N'-bis(2-ethanesulfonic acid) http://www.bioassayontology.org/bao#BAO_0003055 octyl glucoside http://www.bioassayontology.org/bao#BAO_0003043 molecular entity n-octyl-β-D-glucoside http://www.bioassayontology.org/bao#BAO_0003056 tris(2-carboxyethyl)phosphine hydrochloride http://www.bioassayontology.org/bao#BAO_0003043 molecular entity TCEP http://www.bioassayontology.org/bao#BAO_0010077 GPCR Signaling http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics GPCR signaling assay http://www.bioassayontology.org/bao#BAO_0010082 drug absorption assay http://www.bioassayontology.org/bao#BAO_0002182 pharmacokinetic assay drug absorption assay http://www.bioassayontology.org/bao#BAO_0010083 permeability assay http://www.bioassayontology.org/bao#BAO_0010082 drug absorption assay permeabillity studies http://www.bioassayontology.org/bao#BAO_0010084 Ussing chamber permeability assay http://www.bioassayontology.org/bao#BAO_0010008 Caco-2 permeability assay Ussing chamber permeability http://www.bioassayontology.org/bao#BAO_0010085 MDCK-BCRP permeability assay http://www.bioassayontology.org/bao#BAO_0010083 permeability assay BCRP-MDCK permeability http://www.bioassayontology.org/bao#BAO_0010086 MDCK permeability assay http://www.bioassayontology.org/bao#BAO_0010083 permeability assay MDCK permeability http://www.bioassayontology.org/bao#BAO_0010087 RRCK permeability assay http://www.bioassayontology.org/bao#BAO_0010083 permeability assay Ralph Russ Canine Kidney assay http://www.bioassayontology.org/bao#BAO_0010088 LLCPK1 monolayer permeability assay http://www.bioassayontology.org/bao#BAO_0010083 permeability assay bidirectional permeability across LLCPK1 monolayers http://www.bioassayontology.org/bao#BAO_0010089 MDCKII monolayer permeability assay http://www.bioassayontology.org/bao#BAO_0010083 permeability assay bidirectional permeability across MDCKII monolayers http://www.bioassayontology.org/bao#BAO_0010090 drug metabolism assay http://www.bioassayontology.org/bao#BAO_0002182 pharmacokinetic assay metabolism in vitro http://www.bioassayontology.org/bao#BAO_0010091 metabolite identification and profiling assay http://www.bioassayontology.org/bao#BAO_0010090 drug metabolism assay metabolite identification and profiling http://www.bioassayontology.org/bao#BAO_0010092 target mediated drug dispositioning http://www.bioassayontology.org/bao#BAO_0010090 drug metabolism assay target mediated drug disposition determination http://www.bioassayontology.org/bao#BAO_0010093 receptor internalization assay http://www.bioassayontology.org/bao#BAO_0010090 drug metabolism assay receptor internalization http://www.bioassayontology.org/bao#BAO_0010094 portal vein study http://www.bioassayontology.org/bao#BAO_0010090 drug metabolism assay portal vein study http://www.bioassayontology.org/bao#BAO_0010095 metabolic stability assay http://www.bioassayontology.org/bao#BAO_0010090 drug metabolism assay metabolic stability http://www.bioassayontology.org/bao#BAO_0010096 cytosol stability assay http://www.bioassayontology.org/bao#BAO_0010095 metabolic stability assay cytosolic stability http://www.bioassayontology.org/bao#BAO_0010097 S9 stability assay http://www.bioassayontology.org/bao#BAO_0010095 metabolic stability assay S9 stability http://www.bioassayontology.org/bao#BAO_0010098 whole blood stability assay http://www.bioassayontology.org/bao#BAO_0010095 metabolic stability assay whole blood stability http://www.bioassayontology.org/bao#BAO_0010099 plasma stability with inhibitors http://www.bioassayontology.org/bao#BAO_0010007 plasma stability assay plasma stability with inhibitor http://www.bioassayontology.org/bao#BAO_0010100 hepatocyte stability assay http://www.bioassayontology.org/bao#BAO_0010095 metabolic stability assay metabolic stability in hepatocytes http://www.bioassayontology.org/bao#BAO_0010101 hepatocyte low clearance relay assay http://www.bioassayontology.org/bao#BAO_0010100 hepatocyte stability assay low intrinsic clearance assay http://www.bioassayontology.org/bao#BAO_0010102 hepatocyte co-culture low clearance assay http://www.bioassayontology.org/bao#BAO_0010100 hepatocyte stability assay low clearance hepatocyte co-culture http://www.bioassayontology.org/bao#BAO_0010103 gastric fluid stability assay http://www.bioassayontology.org/bao#BAO_0010095 metabolic stability assay stabiity in gastric fluids http://www.bioassayontology.org/bao#BAO_0010104 simulated gastric fluid stability assay http://www.bioassayontology.org/bao#BAO_0010243 chemical stability assay simulated gastric fluid stability http://www.bioassayontology.org/bao#BAO_0010105 simulated gastric fluid stability assay (with enzymes) http://www.bioassayontology.org/bao#BAO_0010103 gastric fluid stability assay stability in simulated gastric fluids with enzymes http://www.bioassayontology.org/bao#BAO_0010106 intestinal fluid stability assay http://www.bioassayontology.org/bao#BAO_0010095 metabolic stability assay intestinal fluid stability http://www.bioassayontology.org/bao#BAO_0010107 simulated intestinal fluid stability assay (with enzymes) http://www.bioassayontology.org/bao#BAO_0010106 intestinal fluid stability assay enzymatic simulated intestinal fluid stability http://www.bioassayontology.org/bao#BAO_0010108 simulated intestinal fluid stability assay http://www.bioassayontology.org/bao#BAO_0010243 chemical stability assay simulated intestinal fluid stability http://www.bioassayontology.org/bao#BAO_0010109 interstitial fluid stability assay http://www.bioassayontology.org/bao#BAO_0010095 metabolic stability assay interstitial fluid stability http://www.bioassayontology.org/bao#BAO_0010110 simulated interstitial fluid stability assay http://www.bioassayontology.org/bao#BAO_0010109 interstitial fluid stability assay stability in simulated interstitial fluid http://www.bioassayontology.org/bao#BAO_0010111 tissue homogenate stability assay http://www.bioassayontology.org/bao#BAO_0010095 metabolic stability assay tissue homogenate stability http://www.bioassayontology.org/bao#BAO_0010112 cell homogenate stability assay http://www.bioassayontology.org/bao#BAO_0010095 metabolic stability assay metabolic stability in cell homogenate http://www.bioassayontology.org/bao#BAO_0010113 enzymatic stability assay http://www.bioassayontology.org/bao#BAO_0010095 metabolic stability assay metabolic stability in enzymes http://www.bioassayontology.org/bao#BAO_0010114 enzyme reaction phenotyping http://www.bioassayontology.org/bao#BAO_0010090 drug metabolism assay reaction phenotyping http://www.bioassayontology.org/bao#BAO_0010115 AOX reaction phenotyping http://www.bioassayontology.org/bao#BAO_0010114 enzyme reaction phenotyping in vitro liver cytosol stability for aldehyde oxidase substrates http://www.bioassayontology.org/bao#BAO_0010116 FMO reaction phenotyping http://www.bioassayontology.org/bao#BAO_0010114 enzyme reaction phenotyping flavin-containing monooxygenase (fmo3): screening for substrates http://www.bioassayontology.org/bao#BAO_0010117 MAO reaction phenotyping http://www.bioassayontology.org/bao#BAO_0010114 enzyme reaction phenotyping monoamine oxidase stability http://www.bioassayontology.org/bao#BAO_0010118 hepatocyte relay with inhibitors http://www.bioassayontology.org/bao#BAO_0010114 enzyme reaction phenotyping hepatocyte relay with inhibitors http://www.bioassayontology.org/bao#BAO_0010119 CES reaction phenotyping http://www.bioassayontology.org/bao#BAO_0010114 enzyme reaction phenotyping carboxylesterases (ces1 and ces2): screening for substrate and inhibitor http://www.bioassayontology.org/bao#BAO_0010120 esterase chemical inhibition http://www.bioassayontology.org/bao#BAO_0010119 CES reaction phenotyping esterase chemical inhibitors http://www.bioassayontology.org/bao#BAO_0010121 esterase metabolite formation kinetics http://www.bioassayontology.org/bao#BAO_0010119 CES reaction phenotyping esterase metabolite formation kinetics http://www.bioassayontology.org/bao#BAO_0010122 recombinant esterases http://www.bioassayontology.org/bao#BAO_0010119 CES reaction phenotyping recombinant esterases http://www.bioassayontology.org/bao#BAO_0010123 CYP reaction phenotyping http://www.bioassayontology.org/bao#BAO_0010114 enzyme reaction phenotyping Cytochrome P450 reaction phenotyping http://www.bioassayontology.org/bao#BAO_0010124 CYP chemical inhibition http://www.bioassayontology.org/bao#BAO_0010123 CYP reaction phenotyping CYP phenotyping- chemical inhibition http://www.bioassayontology.org/bao#BAO_0010125 CYP metabolite formation kinetics http://www.bioassayontology.org/bao#BAO_0010123 CYP reaction phenotyping CYP metabolite formation kinetics http://www.bioassayontology.org/bao#BAO_0010126 recombinant CYP reaction phenotyping http://www.bioassayontology.org/bao#BAO_0010123 CYP reaction phenotyping recombinant CYPs reaction phenotyping http://www.bioassayontology.org/bao#BAO_0010127 CYP mAb inhibition http://www.bioassayontology.org/bao#BAO_0010123 CYP reaction phenotyping monoclonal antibody inhibitors of CYP http://www.bioassayontology.org/bao#BAO_0010128 UGT reaction phenotyping http://www.bioassayontology.org/bao#BAO_0010114 enzyme reaction phenotyping UGT substrate identification http://www.bioassayontology.org/bao#BAO_0010129 UGT chemical inhibition http://www.bioassayontology.org/bao#BAO_0010128 UGT reaction phenotyping UGT phenotyping- chemical inhibition http://www.bioassayontology.org/bao#BAO_0010130 UGT metabolite formation kinetics http://www.bioassayontology.org/bao#BAO_0010128 UGT reaction phenotyping UGT metabolite formation kinetics http://www.bioassayontology.org/bao#BAO_0010131 recombinant UGT reaction phenotyping http://www.bioassayontology.org/bao#BAO_0010128 UGT reaction phenotyping recombinant UGTs reaction phenotyping http://www.bioassayontology.org/bao#BAO_0010132 blood to plasma ratio assay http://www.bioassayontology.org/bao#BAO_0002532 tissue distribution assay red blood cell partitioning http://www.bioassayontology.org/bao#BAO_0010133 tissue binding assay http://www.bioassayontology.org/bao#BAO_0002532 tissue distribution assay tissue protein binding assay http://www.bioassayontology.org/bao#BAO_0010134 placental transfer assay http://www.bioassayontology.org/bao#BAO_0002532 tissue distribution assay Placental transfer study http://www.bioassayontology.org/bao#BAO_0010135 plasma protein binding assay http://www.bioassayontology.org/bao#BAO_0002532 tissue distribution assay plasma protein binding (equilibrium dialysis) http://www.bioassayontology.org/bao#BAO_0010136 media binding assay http://www.bioassayontology.org/bao#BAO_0002532 tissue distribution assay stability in induction media http://www.bioassayontology.org/bao#BAO_0010137 BSA binding asssay http://www.bioassayontology.org/bao#BAO_0010136 media binding assay bovine serum albumin binding http://www.bioassayontology.org/bao#BAO_0010138 microsomal binding assay http://www.bioassayontology.org/bao#BAO_0002532 tissue distribution assay microsome protein binding assay http://www.bioassayontology.org/bao#BAO_0010139 drug excretion assay http://www.bioassayontology.org/bao#BAO_0002182 pharmacokinetic assay FDA RPS Pharmacokinetics: Excretion http://www.bioassayontology.org/bao#BAO_0010140 mass balance assay http://www.bioassayontology.org/bao#BAO_0010139 drug excretion assay mass balance study http://www.bioassayontology.org/bao#BAO_0010141 biliary excretion assay http://www.bioassayontology.org/bao#BAO_0010140 mass balance assay excretion into bile http://www.bioassayontology.org/bao#BAO_0010142 milk excretion assay http://www.bioassayontology.org/bao#BAO_0010140 mass balance assay excretion into milk http://www.bioassayontology.org/bao#BAO_0010143 renal excretion assay http://www.bioassayontology.org/bao#BAO_0010140 mass balance assay renal excretion study http://www.bioassayontology.org/bao#BAO_0010144 receptor induction assay http://www.bioassayontology.org/bao#BAO_0002188 drug interaction assay receptor induction http://www.bioassayontology.org/bao#BAO_0010145 Fc/FcRN induction assay http://www.bioassayontology.org/bao#BAO_0010144 receptor induction assay FcRn induction http://www.bioassayontology.org/bao#BAO_0010146 enzyme induction assay http://www.bioassayontology.org/bao#BAO_0002188 drug interaction assay definitive induction http://www.bioassayontology.org/bao#BAO_0010147 CYP induction screen http://www.bioassayontology.org/bao#BAO_0010146 enzyme induction assay CYP induction screen http://www.bioassayontology.org/bao#BAO_0010148 UGT induction assay http://www.bioassayontology.org/bao#BAO_0010146 enzyme induction assay UGT induction assay http://www.bioassayontology.org/bao#BAO_0010149 CYP induction assay http://www.bioassayontology.org/bao#BAO_0010146 enzyme induction assay Induction of cytochrome P450 http://www.bioassayontology.org/bao#BAO_0010150 CYP1A2 induction assay http://www.bioassayontology.org/bao#BAO_0010149 CYP induction assay definitive CYP1A2 induction assay http://www.bioassayontology.org/bao#BAO_0010151 CYP2B6 induction assay http://www.bioassayontology.org/bao#BAO_0010149 CYP induction assay definitive CYP2B6 induction assay http://www.bioassayontology.org/bao#BAO_0010152 CYP2C19 induction assay http://www.bioassayontology.org/bao#BAO_0010149 CYP induction assay definitive CYP2C19 induction assay http://www.bioassayontology.org/bao#BAO_0010153 CYP2C8 induction assay http://www.bioassayontology.org/bao#BAO_0010149 CYP induction assay definitive CYP2C8 induction assay http://www.bioassayontology.org/bao#BAO_0010154 CYP2C9 induction assay http://www.bioassayontology.org/bao#BAO_0010149 CYP induction assay definitive CYP2C9 induction assay http://www.bioassayontology.org/bao#BAO_0010155 CYP3A4 induction assay http://www.bioassayontology.org/bao#BAO_0010149 CYP induction assay definitive CYP3A4 induction assay http://www.bioassayontology.org/bao#BAO_0010156 Relative Induction Score determination http://www.bioassayontology.org/bao#BAO_0010149 CYP induction assay CYP Induction in human hepatocytes - 3A4 Relative Induction Score (RIS) http://www.bioassayontology.org/bao#BAO_0010157 enzyme inhibition assay http://www.bioassayontology.org/bao#BAO_0002188 drug interaction assay enzyme inhibition assay http://www.bioassayontology.org/bao#BAO_0010158 monoamine oxidase inhibition http://www.bioassayontology.org/bao#BAO_0010157 enzyme inhibition assay inhibition of monoamine oxidase http://www.bioassayontology.org/bao#BAO_0010159 CYP inhibition assay http://www.bioassayontology.org/bao#BAO_0010157 enzyme inhibition assay inhibition of cytochrome P450 http://www.bioassayontology.org/bao#BAO_0010160 CYP1A2 inhibition assay http://www.bioassayontology.org/bao#BAO_0010159 CYP inhibition assay CYP1A2 inhibition http://www.bioassayontology.org/bao#BAO_0010161 CYP2B6 inhibition assay http://www.bioassayontology.org/bao#BAO_0010159 CYP inhibition assay CYP2B6 inhibition http://www.bioassayontology.org/bao#BAO_0010162 CYP2C19 inhibition assay http://www.bioassayontology.org/bao#BAO_0010159 CYP inhibition assay CYP2C19 inhibition http://www.bioassayontology.org/bao#BAO_0010163 CYP2C8 inhibition assay http://www.bioassayontology.org/bao#BAO_0010159 CYP inhibition assay CYP2C8 inhibition http://www.bioassayontology.org/bao#BAO_0010164 CYP2C9 inhibition assay http://www.bioassayontology.org/bao#BAO_0010159 CYP inhibition assay CYP2C9 inhibition http://www.bioassayontology.org/bao#BAO_0010165 CYP3A4 inhibition assay http://www.bioassayontology.org/bao#BAO_0010159 CYP inhibition assay CYP3A4 inhibition http://www.bioassayontology.org/bao#BAO_0010166 CYP cocktail IC50 http://www.bioassayontology.org/bao#BAO_0010159 CYP inhibition assay CYP IC50 cocktail http://www.bioassayontology.org/bao#BAO_0010167 CYP single point inhibition http://www.bioassayontology.org/bao#BAO_0010159 CYP inhibition assay CYP single point inhibition http://www.bioassayontology.org/bao#BAO_0010168 definitive CYP IC50 http://www.bioassayontology.org/bao#BAO_0010159 CYP inhibition assay definitive CYP IC50 http://www.bioassayontology.org/bao#BAO_0010169 CYP time-dependent inhibition http://www.bioassayontology.org/bao#BAO_0010157 enzyme inhibition assay time-dependent Inhibition of CYP450 http://www.bioassayontology.org/bao#BAO_0010170 CYP time dependent inhibition IC50 shift http://www.bioassayontology.org/bao#BAO_0010169 CYP time-dependent inhibition Cytochrome P450 time-dependent Inhibition IC50 shift http://www.bioassayontology.org/bao#BAO_0010171 CYP time dependent inhibition Ki/kinact http://www.bioassayontology.org/bao#BAO_0010169 CYP time-dependent inhibition Ki & Kinact (TDI) http://www.bioassayontology.org/bao#BAO_0010172 CYP time dependent inhibition single point http://www.bioassayontology.org/bao#BAO_0010169 CYP time-dependent inhibition time dependent inhibition single point http://www.bioassayontology.org/bao#BAO_0010173 UGT inhibition http://www.bioassayontology.org/bao#BAO_0010157 enzyme inhibition assay UGT inhibition http://www.bioassayontology.org/bao#BAO_0010174 UGT1A1 with BSA http://www.bioassayontology.org/bao#BAO_0010173 UGT inhibition UGT1A1 with BSA http://www.bioassayontology.org/bao#BAO_0010175 UGT1A1 without BSA http://www.bioassayontology.org/bao#BAO_0010173 UGT inhibition UGT1A1 without BSA http://www.bioassayontology.org/bao#BAO_0010176 UGT1A4 with BSA http://www.bioassayontology.org/bao#BAO_0010173 UGT inhibition UGT1A4 with BSA http://www.bioassayontology.org/bao#BAO_0010177 UGT1A4 without BSA http://www.bioassayontology.org/bao#BAO_0010173 UGT inhibition UGT1A4 without BSA http://www.bioassayontology.org/bao#BAO_0010178 UGT1A6 with BSA http://www.bioassayontology.org/bao#BAO_0010173 UGT inhibition UGT1A6 with BSA http://www.bioassayontology.org/bao#BAO_0010179 UGT1A6 without BSA http://www.bioassayontology.org/bao#BAO_0010173 UGT inhibition UGT1A6 without BSA http://www.bioassayontology.org/bao#BAO_0010180 UGT1A9 with BSA http://www.bioassayontology.org/bao#BAO_0010173 UGT inhibition UGT1A9 with BSA http://www.bioassayontology.org/bao#BAO_0010181 UGT1A9 without BSA http://www.bioassayontology.org/bao#BAO_0010173 UGT inhibition UGT1A9 without BSA http://www.bioassayontology.org/bao#BAO_0010182 UGT2B15 with BSA http://www.bioassayontology.org/bao#BAO_0010173 UGT inhibition UGT2B15 with BSA http://www.bioassayontology.org/bao#BAO_0010183 UGT2B15 without BSA http://www.bioassayontology.org/bao#BAO_0010173 UGT inhibition UGT2B15 without BSA http://www.bioassayontology.org/bao#BAO_0010184 UGT2B7 with BSA http://www.bioassayontology.org/bao#BAO_0010173 UGT inhibition UGT2B7 with BSA http://www.bioassayontology.org/bao#BAO_0010185 UGT2B7 without BSA http://www.bioassayontology.org/bao#BAO_0010173 UGT inhibition UGT2B7 without BSA http://www.bioassayontology.org/bao#BAO_0010186 transporter induction assay http://www.bioassayontology.org/bao#BAO_0003008 transporter assay induction of transport proteins http://www.bioassayontology.org/bao#BAO_0010187 p-gp induction assay http://www.bioassayontology.org/bao#BAO_0010186 transporter induction assay multi-drug resistance 1 induction http://www.bioassayontology.org/bao#BAO_0010188 transporter inhibition assay http://www.bioassayontology.org/bao#BAO_0003008 transporter assay transporter inhibition assay http://www.bioassayontology.org/bao#BAO_0010189 efflux transporter inhibition assay http://www.bioassayontology.org/bao#BAO_0010188 transporter inhibition assay efflux transporter inhibition assay http://www.bioassayontology.org/bao#BAO_0010190 BSEP inhibition assay http://www.bioassayontology.org/bao#BAO_0010189 efflux transporter inhibition assay BSEP inhibition http://www.bioassayontology.org/bao#BAO_0010191 BCRP inhibition assay http://www.bioassayontology.org/bao#BAO_0010189 efflux transporter inhibition assay inhibition of BCRP http://www.bioassayontology.org/bao#BAO_0010192 MRP2 inhibition assay http://www.bioassayontology.org/bao#BAO_0010189 efflux transporter inhibition assay MRP2 inhibition http://www.bioassayontology.org/bao#BAO_0010193 P-gp inhibition assay http://www.bioassayontology.org/bao#BAO_0010189 efflux transporter inhibition assay multi-drug resistance 1 inhibition http://www.bioassayontology.org/bao#BAO_0010194 MATE1 inhibition assay http://www.bioassayontology.org/bao#BAO_0010189 efflux transporter inhibition assay SLC47A1 inhibition http://www.bioassayontology.org/bao#BAO_0010195 MATE2 inhibition assay http://www.bioassayontology.org/bao#BAO_0010189 efflux transporter inhibition assay SLC47A2 inhibition http://www.bioassayontology.org/bao#BAO_0010196 uptake transporter inhibition assay http://www.bioassayontology.org/bao#BAO_0010188 transporter inhibition assay uptake transporter inhibition http://www.bioassayontology.org/bao#BAO_0010197 OAT1 inhibition assay http://www.bioassayontology.org/bao#BAO_0010196 uptake transporter inhibition assay SLC22A6 inhibition http://www.bioassayontology.org/bao#BAO_0010198 OAT2 inhibition assay http://www.bioassayontology.org/bao#BAO_0010196 uptake transporter inhibition assay SLC22A7 inhibition http://www.bioassayontology.org/bao#BAO_0010199 OAT3 inhibition assay http://www.bioassayontology.org/bao#BAO_0010196 uptake transporter inhibition assay SLC22A8 inhibition http://www.bioassayontology.org/bao#BAO_0010200 OATP1B1 inhibition assay http://www.bioassayontology.org/bao#BAO_0010196 uptake transporter inhibition assay SLCO1B1 inhibition http://www.bioassayontology.org/bao#BAO_0010201 OATP1B3 inhibition assay http://www.bioassayontology.org/bao#BAO_0010196 uptake transporter inhibition assay SLCO1B3 inhibition http://www.bioassayontology.org/bao#BAO_0010202 OCT1 inhibition assay http://www.bioassayontology.org/bao#BAO_0010196 uptake transporter inhibition assay SLC22A1 inhibition http://www.bioassayontology.org/bao#BAO_0010203 OCT2 inhibition assay http://www.bioassayontology.org/bao#BAO_0010196 uptake transporter inhibition assay SLC22A inhibition http://www.bioassayontology.org/bao#BAO_0010204 transporter substrate assay http://www.bioassayontology.org/bao#BAO_0003008 transporter assay transporter substrate identification http://www.bioassayontology.org/bao#BAO_0010205 efflux transporter substrate assay http://www.bioassayontology.org/bao#BAO_0010204 transporter substrate assay efflux transporter substrate identification http://www.bioassayontology.org/bao#BAO_0010206 P-gp substrate assay http://www.bioassayontology.org/bao#BAO_0010205 efflux transporter substrate assay P-gp substrate identification assay http://www.bioassayontology.org/bao#BAO_0010207 MRP2 substrate assay http://www.bioassayontology.org/bao#BAO_0010205 efflux transporter substrate assay MRP2 substrate http://www.bioassayontology.org/bao#BAO_0010208 BCRP substrate assay http://www.bioassayontology.org/bao#BAO_0010205 efflux transporter substrate assay BCRP substrate identification assay http://www.bioassayontology.org/bao#BAO_0010209 MATE1 substrate assay http://www.bioassayontology.org/bao#BAO_0010205 efflux transporter substrate assay SLC47A1 substrate http://www.bioassayontology.org/bao#BAO_0010210 MATE2 substrate assay http://www.bioassayontology.org/bao#BAO_0010205 efflux transporter substrate assay SLC47A2 substrate http://www.bioassayontology.org/bao#BAO_0010211 uptake transporter substrate assay http://www.bioassayontology.org/bao#BAO_0010204 transporter substrate assay uptake transporter substrate identification http://www.bioassayontology.org/bao#BAO_0010212 OAT1 substrate assay http://www.bioassayontology.org/bao#BAO_0010211 uptake transporter substrate assay SLC22A6 substrate http://www.bioassayontology.org/bao#BAO_0010213 OAT2 substrate assay http://www.bioassayontology.org/bao#BAO_0010211 uptake transporter substrate assay SLC22A7 substrate http://www.bioassayontology.org/bao#BAO_0010214 OAT3 substrate assay http://www.bioassayontology.org/bao#BAO_0010211 uptake transporter substrate assay SLC22A8 substrate http://www.bioassayontology.org/bao#BAO_0010215 OATP1B1 substrate assay http://www.bioassayontology.org/bao#BAO_0010211 uptake transporter substrate assay SLCO1B1 substrate http://www.bioassayontology.org/bao#BAO_0010216 OATP1B3 substrate assay http://www.bioassayontology.org/bao#BAO_0010211 uptake transporter substrate assay SLCO1B3 substrate http://www.bioassayontology.org/bao#BAO_0010217 OCT1 substrate assay http://www.bioassayontology.org/bao#BAO_0010211 uptake transporter substrate assay SLC22A1 substrate http://www.bioassayontology.org/bao#BAO_0010218 OCT2 substrate assay http://www.bioassayontology.org/bao#BAO_0010211 uptake transporter substrate assay SLC22A substrate http://www.bioassayontology.org/bao#BAO_0010219 OATP2B1 substrate assay http://www.bioassayontology.org/bao#BAO_0010211 uptake transporter substrate assay SLCO2B1 substrate http://www.bioassayontology.org/bao#BAO_0010220 hepatocyte uptake assay http://www.bioassayontology.org/bao#BAO_0010211 uptake transporter substrate assay hepatocyte uptake http://www.bioassayontology.org/bao#BAO_0010221 sandwich cultured human hepatocyte assay http://www.bioassayontology.org/bao#BAO_0010220 hepatocyte uptake assay sandwich-cultured human hepatocytes http://www.bioassayontology.org/bao#BAO_0010222 plated human hepatocytes assay http://www.bioassayontology.org/bao#BAO_0010220 hepatocyte uptake assay plated primary human hepatocytes http://www.bioassayontology.org/bao#BAO_0010223 pharmacometrics http://www.bioassayontology.org/bao#BAO_0002182 pharmacokinetic assay pharmacometrics and modeling http://www.bioassayontology.org/bao#BAO_0010224 PBPK modeling http://www.bioassayontology.org/bao#BAO_0010223 pharmacometrics pharmacokinetic (PBPK) modeling http://www.bioassayontology.org/bao#BAO_0010225 method development and validation http://www.bioassayontology.org/bao#BAO_0002182 pharmacokinetic assay methods of analysis http://www.bioassayontology.org/bao#BAO_0010226 other pharmacokinetic studies http://www.bioassayontology.org/bao#BAO_0002182 pharmacokinetic assay other pharmacokinetic studies http://www.bioassayontology.org/bao#BAO_0010227 non-rodent PK http://www.bioassayontology.org/bao#BAO_0002182 pharmacokinetic assay PK non-rodent http://www.bioassayontology.org/bao#BAO_0010228 non-rodent excretion in urine http://www.bioassayontology.org/bao#BAO_0010227 non-rodent PK non-rodent urinary excretion http://www.bioassayontology.org/bao#BAO_0010229 non-rodent IV clearance http://www.bioassayontology.org/bao#BAO_0010227 non-rodent PK non-rodent IV clearance http://www.bioassayontology.org/bao#BAO_0010230 non-rodent IV half-life http://www.bioassayontology.org/bao#BAO_0010227 non-rodent PK non-rodent IV half-life http://www.bioassayontology.org/bao#BAO_0010231 non-rodent oral bioavailability http://www.bioassayontology.org/bao#BAO_0010227 non-rodent PK non-rodent F http://www.bioassayontology.org/bao#BAO_0010232 non-rodent oral half-life http://www.bioassayontology.org/bao#BAO_0010227 non-rodent PK non-rodent oral half-life http://www.bioassayontology.org/bao#BAO_0010233 non-rodent Vdss http://www.bioassayontology.org/bao#BAO_0010227 non-rodent PK non-rodent Vdss http://www.bioassayontology.org/bao#BAO_0010234 rodent PK http://www.bioassayontology.org/bao#BAO_0002182 pharmacokinetic assay PK rodent http://www.bioassayontology.org/bao#BAO_0010235 rodent excretion in urine http://www.bioassayontology.org/bao#BAO_0010234 rodent PK rodent urinary excretion http://www.bioassayontology.org/bao#BAO_0010236 rodent IV clearance http://www.bioassayontology.org/bao#BAO_0010234 rodent PK rodent IV clearance http://www.bioassayontology.org/bao#BAO_0010237 rodent IV half-life http://www.bioassayontology.org/bao#BAO_0010234 rodent PK rodent IV half-life http://www.bioassayontology.org/bao#BAO_0010238 rodent oral bioavailability http://www.bioassayontology.org/bao#BAO_0010234 rodent PK rodent F http://www.bioassayontology.org/bao#BAO_0010239 rodent oral half-life http://www.bioassayontology.org/bao#BAO_0010234 rodent PK rodent oral half-life http://www.bioassayontology.org/bao#BAO_0010240 rodent Vdss http://www.bioassayontology.org/bao#BAO_0010234 rodent PK rodent Vdss http://www.bioassayontology.org/bao#BAO_0010241 lipophilicity assay http://www.bioassayontology.org/bao#BAO_0010009 physicochemical assay LogP/D http://www.bioassayontology.org/bao#BAO_0010242 pKa determination http://www.bioassayontology.org/bao#BAO_0010009 physicochemical assay pKa measurement http://www.bioassayontology.org/bao#BAO_0010243 chemical stability assay http://www.bioassayontology.org/bao#BAO_0010009 physicochemical assay chemical stability http://www.bioassayontology.org/bao#BAO_0010244 pH stability assay http://www.bioassayontology.org/bao#BAO_0010243 chemical stability assay stability-pH profile http://www.bioassayontology.org/bao#BAO_0010245 GSH adduct formation http://www.bioassayontology.org/bao#BAO_0010243 chemical stability assay formation of GSH adducts http://www.bioassayontology.org/bao#BAO_0010246 thermodynamic solubility assay http://www.bioassayontology.org/bao#BAO_0010010 solubility assay thermodynamic solubility http://www.bioassayontology.org/bao#BAO_0010247 turbidimetric solubility assay http://www.bioassayontology.org/bao#BAO_0010010 solubility assay turbidimetric solubility http://www.bioassayontology.org/bao#BAO_0010248 kinome activity assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics kinome screen http://www.bioassayontology.org/bao#BAO_0010249 CRISPR/Cas9 method http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics CRISPR/Cas9 gene editing http://www.bioassayontology.org/bao#BAO_0010250 cell binding assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics cell binding http://www.bioassayontology.org/bao#BAO_0010251 signaling pathway assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics pathway biology http://www.bioassayontology.org/bao#BAO_0010252 protein expression assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics protein expression assay http://www.bioassayontology.org/bao#BAO_0010253 T-cell activation assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics tumor cell - T cell co-culture assay http://www.bioassayontology.org/bao#BAO_0010254 syngeneic tumor model http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics syngeneic tumor models http://www.bioassayontology.org/bao#BAO_0010255 T-cell engraftment http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics T-cell graft http://www.bioassayontology.org/bao#BAO_0010256 in vivo PK/PD assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics pharmocokinetic/pharmocodynamic http://www.bioassayontology.org/bao#BAO_0010257 Dahl salt-sensitive rat model http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics Dahl salt-sensitive rat http://www.bioassayontology.org/bao#BAO_0010258 concentration response assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics concentration response relationship http://www.bioassayontology.org/bao#BAO_0010259 target engagement assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics target occupancy assay http://www.bioassayontology.org/bao#BAO_0010260 delayed-type hypersensitivity model http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics model of delayed type hypersensitivity http://www.bioassayontology.org/bao#BAO_0010261 thermal shift assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics thermofluor study http://www.bioassayontology.org/bao#BAO_0010262 T-cell cytotoxicity assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics tumor cell killing http://www.bioassayontology.org/bao#BAO_0010263 CEREP assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics CEREP screening assay http://www.bioassayontology.org/bao#BAO_0010264 biosensor method http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics biosensor assay http://www.bioassayontology.org/bao#BAO_0010265 Annexin V apoptosis assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics FITC Annexin V apoptosis detection http://www.bioassayontology.org/bao#BAO_0010266 Epitope Mapping http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics Epitope Mapping http://www.bioassayontology.org/bao#BAO_0010267 equilibrium assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics protein binding equilibrium dialysis http://www.bioassayontology.org/bao#BAO_0010268 orthotopic tumor model http://purl.obolibrary.org/obo/NCIT_C79367 Pharmacology: Pharmacodynamic Drug Interactions orthotopic tumor models http://www.bioassayontology.org/bao#BAO_0010269 chemotaxis assay http://purl.obolibrary.org/obo/NCIT_C79365 Pharmacology: Secondary Pharmacodynamics chemotaxis assay http://www.bioassayontology.org/bao#BAO_0010270 PD biomarker assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics biomarker identification http://www.bioassayontology.org/bao#BAO_0010271 MET immunoassay http://www.bioassayontology.org/bao#BAO_0010270 PD biomarker assay pMET immunoassay http://www.bioassayontology.org/bao#BAO_0010272 PAR Immunoassay http://www.bioassayontology.org/bao#BAO_0010270 PD biomarker assay Poly(ADP-Ribose) immunoassay http://www.bioassayontology.org/bao#BAO_0010273 γH2AX, pNBS1, and β-catenin Multiplex Immunofluorescence Assay http://www.bioassayontology.org/bao#BAO_0010270 PD biomarker assay γH2AX, pNBS1, and β-catenin immuno assay http://www.bioassayontology.org/bao#BAO_0010274 γH2Ax immunoassay http://www.bioassayontology.org/bao#BAO_0010270 PD biomarker assay γH2Ax immunofluoresence assay http://www.bioassayontology.org/bao#BAO_0010275 HIF1-alpha assay http://www.bioassayontology.org/bao#BAO_0010270 PD biomarker assay Hypoxia Inducible Factor 1-alpha assay http://www.bioassayontology.org/bao#BAO_0010276 Total Topoisomerase I assay http://www.bioassayontology.org/bao#BAO_0010270 PD biomarker assay Topoisomerase I Immunoassay http://www.bioassayontology.org/bao#BAO_0010277 gpcrMAX℠ GPCR Assay Panel http://purl.obolibrary.org/obo/NCIT_C79365 Pharmacology: Secondary Pharmacodynamics gpcrMAX http://www.bioassayontology.org/bao#BAO_0030001 G2/mitotic-specific cyclin-B1 http://www.bioassayontology.org/bao#BAO_0000175 protein cyclin-B1 http://www.bioassayontology.org/bao#BAO_0030002 Antigen KI-67 http://www.bioassayontology.org/bao#BAO_0000175 protein Ki67 http://www.bioassayontology.org/bao#BAO_0030005 Annexin A5 http://www.bioassayontology.org/bao#BAO_0000365 cytosolic protein Annexin V http://www.bioassayontology.org/bao#BAO_0030007 Vascular cell adhesion protein 1 http://www.bioassayontology.org/bao#BAO_0000237 adhesion VCAM-1 http://www.bioassayontology.org/bao#BAO_0030008 Microtubule-associated proteins 1A/1B light chain 3B http://www.bioassayontology.org/bao#BAO_0000175 protein Autophagy-related protein LC3 B http://www.bioassayontology.org/bao#BAO_0030009 Tubulin beta-3 chain http://www.bioassayontology.org/bao#BAO_0000370 structural Tubulin beta-III http://www.bioassayontology.org/bao#BAO_0030010 Transcription factor p65 http://www.bioassayontology.org/bao#BAO_0000282 transcription factor Nuclear factor NF-kappa-B p65 subunit Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 http://www.bioassayontology.org/bao#BAO_0040001 image analysis method http://www.bioassayontology.org/bao#BAO_0002754 assay data processing method image processing method http://www.bioassayontology.org/bao#BAO_0040033 ligand covalent binding method http://www.bioassayontology.org/bao#BAO_0000123 binding assessment method http://www.bioassayontology.org/bao#BAO_0080007 neurite outgrowth http://www.bioassayontology.org/bao#BAO_0080004 phenotypic mode of action neurite elongation http://www.bioassayontology.org/bao#BAO_0080011 fragments per kilobase of exon per million mapped reads http://www.bioassayontology.org/bao#BAO_0002138 gene-expression profile endpoint FPKM http://www.bioassayontology.org/bao#BAO_0080036 Relative Induction Score http://www.bioassayontology.org/bao#BAO_0002128 physical property endpoint Relative Induction Score (RIS) http://www.bioassayontology.org/bao#BAO_0140047 HEPATOPAC® co-culture kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit HepatoPac® micropatterned co-culture http://www.bioassayontology.org/bao#BAO_0000770 Thrombin Receptor Activator Peptide 6 http://www.bioassayontology.org/bao#BAO_0000325 peptide SFLLRN http://purl.obolibrary.org/obo/CHEBI_137431 antihypotensive agent http://purl.obolibrary.org/obo/CHEBI_35554 cardiovascular drug vasopressor agent http://purl.obolibrary.org/obo/CHEBI_137514 TRPA1 channel agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist transient receptor potential cation channel A1 agonist http://purl.obolibrary.org/obo/CHEBI_137626 EC 1.1.1.146 (11beta-hydroxysteroid dehydrogenase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76835 EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor 11beta-hydroxysteroid:NADP(+) 11-oxidoreductase inhibitors http://purl.obolibrary.org/obo/CHEBI_137692 C3 exoenzyme http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor Rho Inhibitor I http://purl.obolibrary.org/obo/CHEBI_137694 H-1152 dihydrochloride http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor ROCK inhibitor http://purl.obolibrary.org/obo/CHEBI_137736 anxiogenic http://purl.obolibrary.org/obo/CHEBI_35471 psychotropic drug panicogenics http://purl.obolibrary.org/obo/CHEBI_137747 Ciliobrevin D http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor InChI=1S/C17H11Cl3N2O2/c1-8(15(23)11-4-2-9(18)6-13(11)20)16-21-14-7-10(19)3-5-12(14)17(24)22-16/h2-7,21H,1H3,(H,22,24)/b16-8+ http://purl.obolibrary.org/obo/CHEBI_138014 EC 3.4.22.56 (caspase-3) inhibitor http://purl.obolibrary.org/obo/CHEBI_76796 EC 3.4.22.* (cysteine endopeptidase) inhibitor yama protein inhibitors http://purl.obolibrary.org/obo/CHEBI_138033 Dotarizine http://purl.obolibrary.org/obo/CHEBI_35620 vasodilator agent 1-(Diphenylmethyl)-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazin http://purl.obolibrary.org/obo/CHEBI_137401 capsaicin receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist transient receptor potential cation channel subfamily V member 1 agonists http://purl.obolibrary.org/obo/CHEBI_137566 EC 2.5.1.48 (cystathionine gamma-synthase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76663 EC 2.5.1.* (non-methyl-alkyl or aryl transferase) inhibitor O(4)-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase inhibitors http://purl.obolibrary.org/obo/CHEBI_137684 Papio hamadryas metabolite http://purl.obolibrary.org/obo/CHEBI_75768 mammalian metabolite Papio hamadryas metabolites http://purl.obolibrary.org/obo/CHEBI_138015 endocrine disruptor http://purl.obolibrary.org/obo/CHEBI_51061 hormone receptor modulator hormonally active agents http://www.bioassayontology.org/bao#BAO_0002904 HBSS http://www.bioassayontology.org/bao#BAO_0003043 molecular entity Hank's balanced salt solution http://www.bioassayontology.org/bao#BAO_0030004 Transcription factor AP-1 http://www.bioassayontology.org/bao#BAO_0000282 transcription factor c-jun http://www.bioassayontology.org/bao#BAO_0000947 Interleukin-8 http://www.bioassayontology.org/bao#BAO_0000369 secreted IL-8 http://www.bioassayontology.org/bao#BAO_0000987 para-nitrophenylphosphate http://www.bioassayontology.org/bao#BAO_0003043 molecular entity PNPP http://purl.obolibrary.org/obo/CLO_0037228 GripTite 293 MSR cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 GripTite™ 293 MSR http://www.bioassayontology.org/bao#BAO_0002806 generic hydrolase enzyme activity assay http://www.bioassayontology.org/bao#BAO_0002790 hydrolase activity assay http://www.bioassayontology.org/bao#BAO_0002762 phosphatase activity assay http://www.bioassayontology.org/bao#BAO_0002790 hydrolase activity assay http://www.bioassayontology.org/bao#BAO_0002764 protease activity assay http://www.bioassayontology.org/bao#BAO_0002790 hydrolase activity assay http://www.bioassayontology.org/bao#BAO_0002435 gene knockdown by dsRNA transfection http://www.bioassayontology.org/bao#BAO_0002434 gene knockdown by RNA interference http://www.bioassayontology.org/bao#BAO_0002436 gene knockdown by lentiviral shRNA transduction http://www.bioassayontology.org/bao#BAO_0002434 gene knockdown by RNA interference http://www.bioassayontology.org/bao#BAO_0170032 blebbed dendrite phenotype http://www.bioassayontology.org/bao#BAO_0170023 blebbed neurite phenotype http://www.bioassayontology.org/bao#BAO_0170031 blebbed axon phenotype http://www.bioassayontology.org/bao#BAO_0170023 blebbed neurite phenotype http://www.bioassayontology.org/bao#BAO_0002782 P-selectin glycoprotein ligand 1 http://www.bioassayontology.org/bao#BAO_0000392 generic membrane protein http://www.bioassayontology.org/bao#BAO_0002483 vital staining of cells http://www.bioassayontology.org/bao#BAO_0002480 vital dye staining http://www.bioassayontology.org/bao#BAO_0002484 vital staining of organelles http://www.bioassayontology.org/bao#BAO_0002480 vital dye staining http://purl.obolibrary.org/obo/DOID_60004 malignant cystadenoma http://purl.obolibrary.org/obo/DOID_0080364 malignant adenoma http://purl.obolibrary.org/obo/CHEBI_50444 adenosine phosphodiesterase inhibitor http://purl.obolibrary.org/obo/CHEBI_50218 EC 3.1.4.* (phosphoric diester hydrolase) inhibitor http://purl.obolibrary.org/obo/CHEBI_132717 bleaching agent http://purl.obolibrary.org/obo/CHEBI_33893 reagent http://purl.obolibrary.org/obo/CHEBI_60646 chiral reagent http://purl.obolibrary.org/obo/CHEBI_33893 reagent http://purl.obolibrary.org/obo/CHEBI_51266 gelator http://purl.obolibrary.org/obo/CHEBI_33893 reagent http://purl.obolibrary.org/obo/CHEBI_51267 swelling agent http://purl.obolibrary.org/obo/CHEBI_33893 reagent http://www.bioassayontology.org/bao#BAO_0001217 Amplex red reagent http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0001218 Atto 495 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0001220 QuantaBlu http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0001222 Ellman and apos's reagent http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://purl.obolibrary.org/obo/CHEBI_63146 insulin release inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor http://purl.obolibrary.org/obo/CHEBI_51060 hormone agonist http://purl.obolibrary.org/obo/CHEBI_51061 hormone receptor modulator http://purl.obolibrary.org/obo/CHEBI_62873 odorant receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist http://purl.obolibrary.org/obo/CHEBI_51577 partial prostacyclin agonist http://purl.obolibrary.org/obo/CHEBI_35620 vasodilator agent http://purl.obolibrary.org/obo/CHEBI_52216 photobiochemical role http://purl.obolibrary.org/obo/CHEBI_52215 photochemical role http://purl.obolibrary.org/obo/CHEBI_76720 antisense oligonucleotide http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role http://purl.obolibrary.org/obo/CHEBI_60816 immunogen http://purl.obolibrary.org/obo/CHEBI_59132 antigen http://purl.obolibrary.org/obo/CHEBI_67268 HIV-1 integrase inhibitor http://purl.obolibrary.org/obo/CHEBI_76668 EC 2.7.* (P-containing group transferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_20854 ATP synthase inhibitor http://purl.obolibrary.org/obo/CHEBI_25355 mitochondrial respiratory-chain inhibitor http://purl.obolibrary.org/obo/CHEBI_39379 lepidopteran inhibitor of chitin biosynthesis http://purl.obolibrary.org/obo/CHEBI_23100 chitin synthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_39378 homopteran inhibitor of chitin biosynthesis http://purl.obolibrary.org/obo/CHEBI_23100 chitin synthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role http://purl.obolibrary.org/obo/CHEBI_24432 biological role http://purl.obolibrary.org/obo/CHEBI_52208 biophysical role http://purl.obolibrary.org/obo/CHEBI_24432 biological role http://purl.obolibrary.org/obo/CHEBI_52211 physiological role http://purl.obolibrary.org/obo/CHEBI_24432 biological role http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role http://purl.obolibrary.org/obo/CHEBI_24432 biological role http://purl.obolibrary.org/obo/CHEBI_76219 fluorogen http://purl.obolibrary.org/obo/CHEBI_24432 biological role http://www.bioassayontology.org/bao#BAO_0002001 measured entity http://purl.obolibrary.org/obo/CHEBI_24432 biological role http://www.bioassayontology.org/bao#BAO_0002756 second messenger http://purl.obolibrary.org/obo/CHEBI_24432 biological role http://www.bioassayontology.org/bao#BAO_0002760 DNA tag http://purl.obolibrary.org/obo/CHEBI_24432 biological role http://www.bioassayontology.org/bao#BAO_0002798 detected entity http://purl.obolibrary.org/obo/CHEBI_24432 biological role http://www.bioassayontology.org/bao#BAO_0002932 screened entity role http://purl.obolibrary.org/obo/CHEBI_24432 biological role http://www.bioassayontology.org/bao#BAO_0003067 product http://purl.obolibrary.org/obo/CHEBI_24432 biological role http://purl.obolibrary.org/obo/CHEBI_74152 mordant http://purl.obolibrary.org/obo/CHEBI_33232 application http://purl.obolibrary.org/obo/CHEBI_50406 probe http://purl.obolibrary.org/obo/CHEBI_33232 application http://purl.obolibrary.org/obo/CHEBI_33292 fuel http://purl.obolibrary.org/obo/CHEBI_33232 application http://purl.obolibrary.org/obo/CHEBI_50533 protein denaturant http://purl.obolibrary.org/obo/CHEBI_33232 application http://purl.obolibrary.org/obo/CHEBI_74886 neoglycolipid probe http://purl.obolibrary.org/obo/CHEBI_33232 application http://www.bioassayontology.org/bao#BAO_0080029 quantified entity http://purl.obolibrary.org/obo/CHEBI_33232 application http://purl.obolibrary.org/obo/CHEBI_51374 GABA agent http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent http://purl.obolibrary.org/obo/CHEBI_50510 potassium channel modulator http://purl.obolibrary.org/obo/CHEBI_38632 membrane transport modulator http://purl.obolibrary.org/obo/CHEBI_25078 luciferin http://purl.obolibrary.org/obo/CHEBI_52216 photobiochemical role http://purl.obolibrary.org/obo/CHEBI_37336 radioactive imaging agent http://purl.obolibrary.org/obo/CHEBI_37334 diagnostic imaging agent http://purl.obolibrary.org/obo/CHEBI_37337 ultrasound contrast agent http://purl.obolibrary.org/obo/CHEBI_37334 diagnostic imaging agent http://purl.obolibrary.org/obo/CHEBI_38234 DNA polymerase inhibitor http://purl.obolibrary.org/obo/CHEBI_76815 EC 2.7.7.* (nucleotidyltransferase) inhibitor http://purl.obolibrary.org/obo/CHEBI_50509 potassium channel blocker http://purl.obolibrary.org/obo/CHEBI_50510 potassium channel modulator http://purl.obolibrary.org/obo/CHEBI_50507 appetite depressant http://purl.obolibrary.org/obo/CHEBI_50780 appetite regulator http://purl.obolibrary.org/obo/CHEBI_50844 aldosterone antagonist http://purl.obolibrary.org/obo/CHEBI_50843 antimineralocorticoid http://purl.obolibrary.org/obo/CHEBI_61774 inositol phosphorylceramide synthase inhibitor http://purl.obolibrary.org/obo/CHEBI_76881 EC 2.7.1.* (phosphotransferases with an alcohol group as acceptor) inhibitor http://www.bioassayontology.org/bao#BAO_0190007 cells per well http://purl.obolibrary.org/obo/UO_0000200 cell concentration unit http://www.bioassayontology.org/bao#BAO_0190008 cells per microliter http://purl.obolibrary.org/obo/UO_0000200 cell concentration unit http://purl.obolibrary.org/obo/PATO_0000325 obsolete bright http://purl.obolibrary.org/obo/PATO_0000049 intensity http://www.bioassayontology.org/bao#BAO_0003074 endogenous http://purl.obolibrary.org/obo/PATO_0002182 molecular quality http://www.bioassayontology.org/bao#BAO_0000038 unlabeled http://purl.obolibrary.org/obo/PATO_0002182 molecular quality http://www.bioassayontology.org/bao#BAO_0000037 labeled http://purl.obolibrary.org/obo/PATO_0002182 molecular quality http://www.bioassayontology.org/bao#BAO_0000138 molecular structure http://purl.obolibrary.org/obo/PATO_0002182 molecular quality http://www.bioassayontology.org/bao#BAO_0002618 purity http://purl.obolibrary.org/obo/PATO_0002182 molecular quality http://www.bioassayontology.org/bao#BAO_0003072 activated http://purl.obolibrary.org/obo/PATO_0002182 molecular quality http://www.bioassayontology.org/bao#BAO_0003073 synthetic http://purl.obolibrary.org/obo/PATO_0002182 molecular quality http://purl.obolibrary.org/obo/DOID_4916 pituitary carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma http://purl.obolibrary.org/obo/DOID_5716 hormone producing pituitary cancer http://purl.obolibrary.org/obo/DOID_1785 pituitary cancer http://purl.obolibrary.org/obo/DOID_5580 pancreatic gastrinoma http://purl.obolibrary.org/obo/DOID_1799 islet cell tumor http://purl.obolibrary.org/obo/DOID_572 mononeuritis of upper limb and mononeuritis multiplex http://purl.obolibrary.org/obo/DOID_1802 mononeuritis http://purl.obolibrary.org/obo/DOID_3689 brachial plexus neuritis http://purl.obolibrary.org/obo/DOID_3690 brachial plexus neuropathy http://purl.obolibrary.org/obo/DOID_3842 skull base cancer http://purl.obolibrary.org/obo/DOID_1863 skull cancer http://purl.obolibrary.org/obo/DOID_1875 impotence http://purl.obolibrary.org/obo/DOID_1876 sexual dysfunction http://purl.obolibrary.org/obo/DOID_2828 acalculous cholecystitis http://purl.obolibrary.org/obo/DOID_1949 cholecystitis http://purl.obolibrary.org/obo/DOID_9766 xanthogranulomatous cholecystitis http://purl.obolibrary.org/obo/DOID_1949 cholecystitis http://purl.obolibrary.org/obo/DOID_3192 neurilemmoma http://purl.obolibrary.org/obo/DOID_2001 neuroma http://purl.obolibrary.org/obo/DOID_4921 eccrine sweat gland cancer http://purl.obolibrary.org/obo/DOID_2095 sweat gland cancer http://purl.obolibrary.org/obo/DOID_14693 Clouston syndrome http://purl.obolibrary.org/obo/DOID_0050736 autosomal dominant disease http://purl.obolibrary.org/obo/DOID_5567 ovarian germ cell teratoma http://purl.obolibrary.org/obo/DOID_2156 ovarian germ cell cancer http://purl.obolibrary.org/obo/DOID_4645 retinal cancer http://purl.obolibrary.org/obo/DOID_5679 retinal disease http://purl.obolibrary.org/obo/DOID_292 lacrimal system cancer http://purl.obolibrary.org/obo/DOID_1400 lacrimal apparatus disease http://purl.obolibrary.org/obo/DOID_6199 cornea cancer http://purl.obolibrary.org/obo/DOID_10124 corneal disease http://purl.obolibrary.org/obo/DOID_2519 testicular disease http://purl.obolibrary.org/obo/DOID_48 male reproductive system disease http://purl.obolibrary.org/obo/DOID_4031 eosinophilic gastroenteritis http://purl.obolibrary.org/obo/DOID_2326 gastroenteritis http://purl.obolibrary.org/obo/DOID_1936 atherosclerosis http://purl.obolibrary.org/obo/DOID_2348 arteriosclerotic cardiovascular disease http://purl.obolibrary.org/obo/DOID_5132 leiomyoma cutis http://purl.obolibrary.org/obo/DOID_2438 dermis tumor http://purl.obolibrary.org/obo/DOID_3946 pituitary-dependent Cushing's disease http://purl.obolibrary.org/obo/DOID_2444 hyperpituitarism http://purl.obolibrary.org/obo/DOID_2599 glottis carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma http://purl.obolibrary.org/obo/DOID_3675 childhood kidney cancer http://purl.obolibrary.org/obo/DOID_263 kidney cancer http://purl.obolibrary.org/obo/DOID_4919 renal pelvis carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma http://purl.obolibrary.org/obo/DOID_5758 malignant mesenchymoma http://purl.obolibrary.org/obo/DOID_2668 mesenchymoma http://purl.obolibrary.org/obo/DOID_6404 metanephric adenoma http://purl.obolibrary.org/obo/DOID_2697 renal adenoma http://purl.obolibrary.org/obo/DOID_366 olfactory nerve neoplasm http://purl.obolibrary.org/obo/DOID_2815 cranial nerve malignant neoplasm http://purl.obolibrary.org/obo/DOID_3752 larynx verrucous carcinoma http://purl.obolibrary.org/obo/DOID_2876 laryngeal squamous cell carcinoma http://purl.obolibrary.org/obo/DOID_6204 follicular adenoma http://purl.obolibrary.org/obo/DOID_2891 thyroid adenoma http://purl.obolibrary.org/obo/DOID_6740 cervix small cell carcinoma http://purl.obolibrary.org/obo/DOID_2893 cervix carcinoma http://purl.obolibrary.org/obo/DOID_4796 space motion sickness http://purl.obolibrary.org/obo/DOID_2951 motion sickness http://purl.obolibrary.org/obo/DOID_5834 spermatocytoma http://purl.obolibrary.org/obo/DOID_2998 testicular cancer http://purl.obolibrary.org/obo/DOID_5842 testis seminoma http://purl.obolibrary.org/obo/DOID_2998 testicular cancer http://purl.obolibrary.org/obo/DOID_5331 testicular granulosa cell tumor http://purl.obolibrary.org/obo/DOID_2999 granulosa cell tumor http://purl.obolibrary.org/obo/DOID_4845 pilomyxoid astrocytoma http://purl.obolibrary.org/obo/DOID_3069 astrocytoma http://purl.obolibrary.org/obo/DOID_7005 gemistocytic astrocytoma http://purl.obolibrary.org/obo/DOID_3069 astrocytoma http://purl.obolibrary.org/obo/DOID_7305 astroblastoma http://purl.obolibrary.org/obo/DOID_3069 astrocytoma http://purl.obolibrary.org/obo/DOID_9675 pulmonary emphysema http://purl.obolibrary.org/obo/DOID_3083 chronic obstructive pulmonary disease http://purl.obolibrary.org/obo/DOID_409 liver disease http://purl.obolibrary.org/obo/DOID_3118 hepatobiliary disease http://purl.obolibrary.org/obo/DOID_9741 biliary tract disease http://purl.obolibrary.org/obo/DOID_3118 hepatobiliary disease http://purl.obolibrary.org/obo/DOID_4697 perineurioma http://purl.obolibrary.org/obo/DOID_3193 peripheral nerve sheath neoplasm http://purl.obolibrary.org/obo/DOID_5940 malignant peripheral nerve sheath tumor http://purl.obolibrary.org/obo/DOID_3193 peripheral nerve sheath neoplasm http://purl.obolibrary.org/obo/DOID_962 neurofibroma http://purl.obolibrary.org/obo/DOID_3193 peripheral nerve sheath neoplasm http://purl.obolibrary.org/obo/DOID_4051 alveolar rhabdomyosarcoma http://purl.obolibrary.org/obo/DOID_3247 rhabdomyosarcoma http://purl.obolibrary.org/obo/DOID_3282 dendritic cell thymoma http://purl.obolibrary.org/obo/DOID_9500 leukocyte disease http://purl.obolibrary.org/obo/DOID_6530 cortical thymoma http://purl.obolibrary.org/obo/DOID_3282 dendritic cell thymoma http://purl.obolibrary.org/obo/DOID_7926 epithelial malignant thymoma http://purl.obolibrary.org/obo/DOID_3282 dendritic cell thymoma http://purl.obolibrary.org/obo/DOID_3579 testicular gonadoblastoma http://purl.obolibrary.org/obo/DOID_2519 testicular disease http://purl.obolibrary.org/obo/DOID_2643 perivascular epithelioid cell tumor http://purl.obolibrary.org/obo/DOID_3316 perivascular tumor http://purl.obolibrary.org/obo/DOID_3320 Tay-Sachs disease http://purl.obolibrary.org/obo/DOID_3321 GM2 gangliosidosis http://purl.obolibrary.org/obo/DOID_5769 verruciform xanthoma of skin http://purl.obolibrary.org/obo/DOID_37 skin disease http://purl.obolibrary.org/obo/DOID_3356 localized osteosarcoma http://purl.obolibrary.org/obo/DOID_3347 osteosarcoma http://purl.obolibrary.org/obo/DOID_3376 bone osteosarcoma http://purl.obolibrary.org/obo/DOID_3347 osteosarcoma http://purl.obolibrary.org/obo/DOID_3520 pediatric fibrosarcoma http://purl.obolibrary.org/obo/DOID_3355 fibrosarcoma http://purl.obolibrary.org/obo/DOID_3373 juxtacortical osteosarcoma http://purl.obolibrary.org/obo/DOID_3374 peripheral osteosarcoma http://purl.obolibrary.org/obo/DOID_3374 peripheral osteosarcoma http://purl.obolibrary.org/obo/DOID_3376 bone osteosarcoma http://purl.obolibrary.org/obo/DOID_3378 conventional central osteosarcoma http://purl.obolibrary.org/obo/DOID_3376 bone osteosarcoma http://purl.obolibrary.org/obo/DOID_3377 small cell osteogenic sarcoma http://purl.obolibrary.org/obo/DOID_3378 conventional central osteosarcoma http://purl.obolibrary.org/obo/DOID_6951 telangiectatic osteogenic sarcoma http://purl.obolibrary.org/obo/DOID_3378 conventional central osteosarcoma http://purl.obolibrary.org/obo/DOID_7603 fibrosarcomatous osteosarcoma http://purl.obolibrary.org/obo/DOID_3378 conventional central osteosarcoma http://purl.obolibrary.org/obo/DOID_4330 non-Langerhans-cell histiocytosis http://purl.obolibrary.org/obo/DOID_3405 histiocytosis http://purl.obolibrary.org/obo/DOID_4992 optic nerve glioma http://purl.obolibrary.org/obo/DOID_0060108 brain glioma http://purl.obolibrary.org/obo/DOID_5632 optic nerve sheath meningioma http://purl.obolibrary.org/obo/DOID_3419 optic nerve neoplasm http://purl.obolibrary.org/obo/DOID_3446 anal Paget's disease http://purl.obolibrary.org/obo/DOID_3447 anus adenocarcinoma http://purl.obolibrary.org/obo/DOID_4660 indolent systemic mastocytosis http://purl.obolibrary.org/obo/DOID_349 systemic mastocytosis http://purl.obolibrary.org/obo/DOID_4797 SM-AHNMD http://purl.obolibrary.org/obo/DOID_349 systemic mastocytosis http://purl.obolibrary.org/obo/DOID_349 systemic mastocytosis http://purl.obolibrary.org/obo/DOID_350 mastocytosis http://purl.obolibrary.org/obo/DOID_8418 congenital fibrosarcoma http://purl.obolibrary.org/obo/DOID_0080015 physical disorder http://purl.obolibrary.org/obo/DOID_3525 middle cerebral artery infarction http://purl.obolibrary.org/obo/DOID_3526 cerebral infarction http://purl.obolibrary.org/obo/DOID_687 hepatoblastoma http://purl.obolibrary.org/obo/DOID_3571 liver cancer http://purl.obolibrary.org/obo/DOID_3574 lateral sinus thrombosis http://purl.obolibrary.org/obo/DOID_3572 intracranial sinus thrombosis http://purl.obolibrary.org/obo/DOID_3576 sagittal sinus thrombosis http://purl.obolibrary.org/obo/DOID_3572 intracranial sinus thrombosis http://purl.obolibrary.org/obo/DOID_369 olfactory neuroblastoma http://purl.obolibrary.org/obo/DOID_366 olfactory nerve neoplasm http://purl.obolibrary.org/obo/DOID_490 hemangioma of lung http://purl.obolibrary.org/obo/DOID_255 hemangioma http://purl.obolibrary.org/obo/DOID_5364 pulmonary coin lesion http://purl.obolibrary.org/obo/DOID_3683 lung benign neoplasm http://purl.obolibrary.org/obo/DOID_5395 functioning pituitary adenoma http://purl.obolibrary.org/obo/DOID_3829 pituitary adenoma http://purl.obolibrary.org/obo/DOID_4437 skull base meningioma http://purl.obolibrary.org/obo/DOID_3842 skull base cancer http://purl.obolibrary.org/obo/DOID_2061 nodular hidradenoma http://purl.obolibrary.org/obo/DOID_3896 hidradenoma http://purl.obolibrary.org/obo/DOID_5443 clear cell hidradenoma http://purl.obolibrary.org/obo/DOID_3896 hidradenoma http://purl.obolibrary.org/obo/DOID_4556 lung large cell carcinoma http://purl.obolibrary.org/obo/DOID_3908 lung non-small cell carcinoma http://purl.obolibrary.org/obo/DOID_660 adrenal cortex cancer http://purl.obolibrary.org/obo/DOID_3952 adrenal cortex disease http://purl.obolibrary.org/obo/DOID_4035 lymphocytic gastritis http://purl.obolibrary.org/obo/DOID_4029 gastritis http://purl.obolibrary.org/obo/DOID_8929 atrophic gastritis http://purl.obolibrary.org/obo/DOID_4029 gastritis http://purl.obolibrary.org/obo/DOID_4071 duodenogastric reflux http://purl.obolibrary.org/obo/DOID_4072 duodenum disease http://purl.obolibrary.org/obo/DOID_3558 duodenal obstruction http://purl.obolibrary.org/obo/DOID_4072 duodenum disease http://purl.obolibrary.org/obo/DOID_4073 pancreatic cystadenocarcinoma http://purl.obolibrary.org/obo/DOID_4074 pancreatic adenocarcinoma http://purl.obolibrary.org/obo/DOID_3590 gestational trophoblastic neoplasm http://purl.obolibrary.org/obo/DOID_1380 endometrial cancer http://purl.obolibrary.org/obo/DOID_3593 epithelioid trophoblastic tumor http://purl.obolibrary.org/obo/DOID_1324 lung cancer http://purl.obolibrary.org/obo/DOID_4175 Rh isoimmunization http://purl.obolibrary.org/obo/DOID_4176 blood group incompatibility http://purl.obolibrary.org/obo/DOID_8472 localized scleroderma http://purl.obolibrary.org/obo/DOID_419 scleroderma http://purl.obolibrary.org/obo/DOID_3572 intracranial sinus thrombosis http://purl.obolibrary.org/obo/DOID_4193 intracranial thrombosis http://purl.obolibrary.org/obo/DOID_4409 folliculitis http://purl.obolibrary.org/obo/DOID_2723 dermatitis http://purl.obolibrary.org/obo/DOID_3529 central core myopathy http://purl.obolibrary.org/obo/DOID_422 congenital structural myopathy http://purl.obolibrary.org/obo/DOID_4415 fibrous histiocytoma http://purl.obolibrary.org/obo/DOID_4231 histiocytoma http://purl.obolibrary.org/obo/DOID_4247 coronary restenosis http://purl.obolibrary.org/obo/DOID_4248 coronary stenosis http://purl.obolibrary.org/obo/DOID_1866 giant cell reparative granuloma http://purl.obolibrary.org/obo/DOID_4305 bone giant cell tumor http://purl.obolibrary.org/obo/DOID_4418 cutaneous fibrous histiocytoma http://purl.obolibrary.org/obo/DOID_3165 skin benign neoplasm http://purl.obolibrary.org/obo/DOID_4708 foramen magnum meningioma http://purl.obolibrary.org/obo/DOID_3565 meningioma http://purl.obolibrary.org/obo/DOID_7818 petroclival meningioma http://purl.obolibrary.org/obo/DOID_4437 skull base meningioma http://purl.obolibrary.org/obo/DOID_5838 extragonadal seminoma http://purl.obolibrary.org/obo/DOID_4440 seminoma http://purl.obolibrary.org/obo/DOID_4447 cystoid macular edema http://purl.obolibrary.org/obo/DOID_4449 macular retinal edema http://purl.obolibrary.org/obo/DOID_4463 multilocular clear cell renal cell carcinoma http://purl.obolibrary.org/obo/DOID_4450 renal cell carcinoma http://purl.obolibrary.org/obo/DOID_4455 hereditary renal cell carcinoma http://purl.obolibrary.org/obo/DOID_4450 renal cell carcinoma http://purl.obolibrary.org/obo/DOID_4548 extraskeletal mesenchymal chondrosarcoma http://purl.obolibrary.org/obo/DOID_4549 extraosseous chondrosarcoma http://purl.obolibrary.org/obo/DOID_4044 skeletal muscle neoplasm http://purl.obolibrary.org/obo/DOID_461 muscle benign neoplasm http://purl.obolibrary.org/obo/DOID_4310 smooth muscle tumor http://purl.obolibrary.org/obo/DOID_461 muscle benign neoplasm http://purl.obolibrary.org/obo/DOID_468 intramuscular hemangioma http://purl.obolibrary.org/obo/DOID_255 hemangioma http://purl.obolibrary.org/obo/DOID_5039 myoblastoma http://purl.obolibrary.org/obo/DOID_461 muscle benign neoplasm http://purl.obolibrary.org/obo/DOID_9724 purulent endophthalmitis http://purl.obolibrary.org/obo/DOID_4692 endophthalmitis http://purl.obolibrary.org/obo/DOID_4751 striatonigral degeneration http://purl.obolibrary.org/obo/DOID_4752 multiple system atrophy http://purl.obolibrary.org/obo/DOID_483 cavernous hemangioma http://purl.obolibrary.org/obo/DOID_484 vascular hemostatic disease http://purl.obolibrary.org/obo/DOID_5077 subependymal giant cell astrocytoma http://purl.obolibrary.org/obo/DOID_4843 subependymal glioma http://purl.obolibrary.org/obo/DOID_4843 subependymal glioma http://purl.obolibrary.org/obo/DOID_4844 benign ependymoma http://purl.obolibrary.org/obo/DOID_5504 tanycytic ependymoma http://purl.obolibrary.org/obo/DOID_4844 benign ependymoma http://purl.obolibrary.org/obo/DOID_5505 papillary ependymoma http://purl.obolibrary.org/obo/DOID_4844 benign ependymoma http://purl.obolibrary.org/obo/DOID_4682 extrahepatic bile duct carcinoma http://purl.obolibrary.org/obo/DOID_4897 bile duct carcinoma http://purl.obolibrary.org/obo/DOID_5569 malignant syringoma http://purl.obolibrary.org/obo/DOID_4921 eccrine sweat gland cancer http://purl.obolibrary.org/obo/DOID_4928 intrahepatic cholangiocarcinoma http://purl.obolibrary.org/obo/DOID_4947 cholangiocarcinoma http://purl.obolibrary.org/obo/DOID_2913 acute pancreatitis http://purl.obolibrary.org/obo/DOID_4989 pancreatitis http://purl.obolibrary.org/obo/DOID_4988 alcoholic pancreatitis http://purl.obolibrary.org/obo/DOID_4989 pancreatitis http://purl.obolibrary.org/obo/DOID_4055 ectomesenchymoma http://purl.obolibrary.org/obo/DOID_502 central nervous system mesenchymal non-meningothelial tumor http://purl.obolibrary.org/obo/DOID_2436 glomangioma http://purl.obolibrary.org/obo/DOID_5238 benign perivascular tumor http://purl.obolibrary.org/obo/DOID_6307 ectopic thymus http://purl.obolibrary.org/obo/DOID_533 thymus gland disease http://purl.obolibrary.org/obo/DOID_6032 juvenile type testicular granulosa cell tumor http://purl.obolibrary.org/obo/DOID_5331 testicular granulosa cell tumor http://purl.obolibrary.org/obo/DOID_5374 pilomatrixoma http://purl.obolibrary.org/obo/DOID_5375 hair follicle neoplasm http://purl.obolibrary.org/obo/DOID_6275 TSH producing pituitary tumor http://purl.obolibrary.org/obo/DOID_5395 functioning pituitary adenoma http://purl.obolibrary.org/obo/DOID_6239 non-invasive bladder papillary urothelial neoplasm http://purl.obolibrary.org/obo/DOID_5432 bladder papillary transitional cell neoplasm http://purl.obolibrary.org/obo/DOID_6933 bladder transitional cell papilloma http://purl.obolibrary.org/obo/DOID_5432 bladder papillary transitional cell neoplasm http://purl.obolibrary.org/obo/DOID_5432 bladder papillary transitional cell neoplasm http://purl.obolibrary.org/obo/DOID_5433 urinary tract papillary transitional cell benign neoplasm http://purl.obolibrary.org/obo/DOID_6270 gastric cardia carcinoma http://purl.obolibrary.org/obo/DOID_10548 cardia cancer http://purl.obolibrary.org/obo/DOID_7173 cloacogenic carcinoma http://purl.obolibrary.org/obo/DOID_5525 anal squamous cell carcinoma http://purl.obolibrary.org/obo/DOID_715 T-cell lymphoblastic leukemia/lymphoma http://purl.obolibrary.org/obo/DOID_5603 T-cell acute lymphoblastic leukemia http://purl.obolibrary.org/obo/DOID_2648 sebaceous adenoma http://purl.obolibrary.org/obo/DOID_5759 sebaceous gland neoplasm http://purl.obolibrary.org/obo/DOID_5804 discrete subaortic stenosis http://purl.obolibrary.org/obo/DOID_5805 subvalvular aortic stenosis http://purl.obolibrary.org/obo/DOID_5847 posterior myocardial infarction http://purl.obolibrary.org/obo/DOID_5844 myocardial infarction http://purl.obolibrary.org/obo/DOID_5850 inferior myocardial infarction http://purl.obolibrary.org/obo/DOID_5844 myocardial infarction http://purl.obolibrary.org/obo/DOID_5855 anteroseptal myocardial infarction http://purl.obolibrary.org/obo/DOID_5844 myocardial infarction http://purl.obolibrary.org/obo/DOID_9767 myocardial stunning http://purl.obolibrary.org/obo/DOID_5844 myocardial infarction http://purl.obolibrary.org/obo/DOID_3893 hidrocystoma http://purl.obolibrary.org/obo/DOID_5876 apocrine sweat gland neoplasm http://purl.obolibrary.org/obo/DOID_3895 apocrine adenoma http://purl.obolibrary.org/obo/DOID_5876 apocrine sweat gland neoplasm http://purl.obolibrary.org/obo/DOID_5444 spiradenoma http://purl.obolibrary.org/obo/DOID_5876 apocrine sweat gland neoplasm http://purl.obolibrary.org/obo/DOID_5445 syringocystadenoma papilliferum http://purl.obolibrary.org/obo/DOID_5876 apocrine sweat gland neoplasm http://purl.obolibrary.org/obo/DOID_8162 thyroid Hurthle cell adenoma http://purl.obolibrary.org/obo/DOID_6204 follicular adenoma http://purl.obolibrary.org/obo/DOID_3721 plasmacytoma http://purl.obolibrary.org/obo/DOID_6536 plasma cell neoplasm http://purl.obolibrary.org/obo/DOID_775 intraocular lymphoma http://purl.obolibrary.org/obo/DOID_6903 eye lymphoma http://purl.obolibrary.org/obo/DOID_4449 macular retinal edema http://purl.obolibrary.org/obo/DOID_6929 retinal edema http://purl.obolibrary.org/obo/DOID_583 hemolytic anemia http://purl.obolibrary.org/obo/DOID_720 normocytic anemia http://purl.obolibrary.org/obo/DOID_4648 familial retinoblastoma http://purl.obolibrary.org/obo/DOID_768 retinoblastoma http://purl.obolibrary.org/obo/DOID_7765 Coats disease http://purl.obolibrary.org/obo/DOID_7736 retinal telangiectasia http://purl.obolibrary.org/obo/DOID_8481 rheumatic myocarditis http://purl.obolibrary.org/obo/DOID_104 bacterial infectious disease http://purl.obolibrary.org/obo/DOID_3951 acute myocarditis http://purl.obolibrary.org/obo/DOID_820 myocarditis http://purl.obolibrary.org/obo/DOID_5101 ear cancer http://purl.obolibrary.org/obo/DOID_833 auditory system cancer http://purl.obolibrary.org/obo/DOID_8440 ileus http://purl.obolibrary.org/obo/DOID_8437 intestinal obstruction http://purl.obolibrary.org/obo/DOID_8446 intussusception http://purl.obolibrary.org/obo/DOID_8437 intestinal obstruction http://purl.obolibrary.org/obo/DOID_8517 acute cor pulmonale http://purl.obolibrary.org/obo/DOID_8514 acute pulmonary heart disease http://purl.obolibrary.org/obo/DOID_8593 chronic monocytic leukemia http://purl.obolibrary.org/obo/DOID_8527 monocytic leukemia http://purl.obolibrary.org/obo/DOID_8838 Hodgkin's lymphoma, nodular sclerosis http://purl.obolibrary.org/obo/DOID_8567 Hodgkin's lymphoma http://purl.obolibrary.org/obo/DOID_8573 lichen nitidus http://purl.obolibrary.org/obo/DOID_8574 lichen disease http://purl.obolibrary.org/obo/DOID_8743 erythema infectiosum http://purl.obolibrary.org/obo/DOID_8672 viral exanthem http://purl.obolibrary.org/obo/DOID_9088 parapsoriasis http://purl.obolibrary.org/obo/DOID_8893 psoriasis http://purl.obolibrary.org/obo/DOID_4840 sebaceous carcinoma http://purl.obolibrary.org/obo/DOID_4159 skin cancer http://purl.obolibrary.org/obo/DOID_9905 follicular mucinosis http://purl.obolibrary.org/obo/DOID_9098 sebaceous gland disease http://purl.obolibrary.org/obo/DOID_9401 epididymo-orchitis http://purl.obolibrary.org/obo/DOID_9402 epididymitis http://purl.obolibrary.org/obo/DOID_7327 pseudosarcomatous fibromatosis http://purl.obolibrary.org/obo/DOID_9598 fasciitis http://purl.obolibrary.org/obo/DOID_9600 plantar fasciitis http://purl.obolibrary.org/obo/DOID_9598 fasciitis http://purl.obolibrary.org/obo/DOID_9602 necrotizing fasciitis http://purl.obolibrary.org/obo/DOID_9598 fasciitis http://purl.obolibrary.org/obo/DOID_3362 coronary aneurysm http://purl.obolibrary.org/obo/DOID_9768 heart aneurysm http://purl.obolibrary.org/obo/DOID_9822 partial central choroid dystrophy http://purl.obolibrary.org/obo/DOID_9794 hereditary choroidal atrophy http://purl.obolibrary.org/obo/DOID_9794 hereditary choroidal atrophy http://purl.obolibrary.org/obo/DOID_980 choroidal sclerosis http://purl.obolibrary.org/obo/DOID_9939 dacryocystocele http://purl.obolibrary.org/obo/DOID_9935 chronic inflammation of lacrimal passage http://purl.obolibrary.org/obo/DOID_998 eosinophilia-myalgia syndrome http://purl.obolibrary.org/obo/DOID_999 hypereosinophilic syndrome http://www.bioassayontology.org/bao#BAO_0002684 LYMP2-026 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002715 KOPN-8 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002707 OCI-Ly3 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002714 ML-2 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002670 BJ http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002676 LYMP2-014 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002696 LYMP2-011 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002695 LYMP2-013 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002709 HEC-1-A http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002681 LYMP2-022 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0000732 Cos-7 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0000743 Schneider's Drosophila Line 2 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0000758 U937 (CD59+) http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002673 LYMP2-010 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002674 LYMP2-001 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002675 LYMP2-012 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002677 LYMP2-016 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002679 LYMP2-018 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002682 LYMP2-024 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002683 U3A http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002685 MV-4-11 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002686 LYMP2-007 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002687 LYMP2-006 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002688 LYMP2-002 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002689 LYMP2-025 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002690 LYMP2-023 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002691 LYMP2-021 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002692 LYMP2-019 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002693 LYMP2-017 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002694 RBL-2H3 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002697 LYMP2-009 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002698 LYMP2-005 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002700 LYMP2-003 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002701 LYMP1-003 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002704 LYMP2-008 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002705 MSC 80 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002706 LYMP2-015 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002708 C2C12 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002710 WRO http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002712 SK-BR-3 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002713 H4 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002716 PPC-1 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002680 LYMP2-020 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002717 CSM14.1 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002702 LYMP1-002 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002699 LYMP2-004 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002711 N2a http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002703 C6 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002678 BSC-1 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037251 C17.2 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037253 CEM21 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037255 FA2N-4 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037256 HBL-1 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037257 HMC-1-8 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037258 HMLE_sh_ECAD cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037259 HMLE_sh_eGFP cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037260 HMLE_sh_TWIST cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037262 LEADING LIGHT Wnt Reporter cell line cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037263 MCL-1 1780 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037264 MG213 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037265 PathHunter CHO-K1 DRD2L Beta-Arrestin cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037266 PathHunter CHO-K1 DRD3 Beta-Arrestin cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037268 RAW-Blue cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037269 S16 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037270 SW1 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037271 Tango cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037272 TMD8 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037276 U87-EGFRvIII cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037214 RS-11846 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037216 CHO-S cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037221 RD-HGA16 http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037243 2B4/BCL-2 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037246 2B4/MCL-1 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037247 AVA5 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://purl.obolibrary.org/obo/CLO_0037249 BCL-2 1863 cell http://purl.obolibrary.org/obo/CLO_0000019 永生细胞系细胞 http://www.bioassayontology.org/bao#BAO_0002844 Gram staining http://purl.obolibrary.org/obo/PATO_0001995 organismal quality http://purl.obolibrary.org/obo/CHEBI_52303 sterol methyltransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_76871 EC 2.1.1.* (methyltransferases) inhibitor http://purl.obolibrary.org/obo/CHEBI_62049 acyl donor http://purl.obolibrary.org/obo/CHEBI_17891 donor http://purl.obolibrary.org/obo/CHEBI_51372 neuromuscular agent http://purl.obolibrary.org/obo/CHEBI_23888 drug http://purl.obolibrary.org/obo/CHEBI_50926 angiogenesis modulating agent http://purl.obolibrary.org/obo/CHEBI_23888 drug http://purl.obolibrary.org/obo/CHEBI_35480 analgesic http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role http://purl.obolibrary.org/obo/CHEBI_50739 estrogen receptor modulator http://purl.obolibrary.org/obo/CHEBI_23888 drug http://purl.obolibrary.org/obo/CHEBI_36413 anabolic agent http://purl.obolibrary.org/obo/CHEBI_24621 hormone http://purl.obolibrary.org/obo/CHEBI_50514 vasoconstrictor agent http://purl.obolibrary.org/obo/CHEBI_35554 cardiovascular drug http://purl.obolibrary.org/obo/CHEBI_50855 antiatherogenic agent http://purl.obolibrary.org/obo/CHEBI_35554 cardiovascular drug http://purl.obolibrary.org/obo/CHEBI_90749 antidote to cyanide poisoning http://purl.obolibrary.org/obo/CHEBI_50247 antidote http://purl.obolibrary.org/obo/CHEBI_136860 antidote to sarin poisoning http://purl.obolibrary.org/obo/CHEBI_50247 antidote http://purl.obolibrary.org/obo/CHEBI_39442 fluorescent probe http://purl.obolibrary.org/obo/CHEBI_50406 probe http://purl.obolibrary.org/obo/CHEBI_50927 angiogenesis inducing agent http://purl.obolibrary.org/obo/CHEBI_50926 angiogenesis modulating agent http://purl.obolibrary.org/obo/CHEBI_50907 deaminating agent http://purl.obolibrary.org/obo/CHEBI_51086 chemical role http://www.bioassayontology.org/bao#BAO_0110003 quencher http://purl.obolibrary.org/obo/CHEBI_51086 chemical role http://www.bioassayontology.org/bao#BAO_0110004 detection agent http://purl.obolibrary.org/obo/CHEBI_51086 chemical role http://www.bioassayontology.org/bao#BAO_0110005 rescue treatment http://purl.obolibrary.org/obo/CHEBI_51086 chemical role http://www.bioassayontology.org/bao#BAO_0110006 protein binding ligand http://purl.obolibrary.org/obo/CHEBI_51086 chemical role http://purl.obolibrary.org/obo/CHEBI_50843 antimineralocorticoid http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist http://purl.obolibrary.org/obo/CHEBI_52271 squaraine dye http://purl.obolibrary.org/obo/CHEBI_51121 fluorescent dye http://www.bioassayontology.org/bao#BAO_0001213 Fluormone PL Far Red http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0001215 Fluormone ES2 Green http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0001216 Fluorescein http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0001221 Sytox Orange http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://purl.obolibrary.org/obo/CHEBI_51373 GABA agonist http://purl.obolibrary.org/obo/CHEBI_51374 GABA agent http://purl.obolibrary.org/obo/CHEBI_64054 delta-opioid receptor agonist http://purl.obolibrary.org/obo/CHEBI_60606 opioid receptor agonist http://purl.obolibrary.org/obo/DOID_4194 glucose metabolism disease http://purl.obolibrary.org/obo/DOID_0050013 carbohydrate metabolism disease http://purl.obolibrary.org/obo/DOID_4500 hypokalemia http://purl.obolibrary.org/obo/DOID_0050032 mineral metabolism disease http://purl.obolibrary.org/obo/DOID_10575 calcium metabolism disease http://purl.obolibrary.org/obo/DOID_0050032 mineral metabolism disease http://purl.obolibrary.org/obo/DOID_2351 iron metabolism disease http://purl.obolibrary.org/obo/DOID_0050032 mineral metabolism disease http://purl.obolibrary.org/obo/DOID_2485 phosphorus metabolism disease http://purl.obolibrary.org/obo/DOID_0050032 mineral metabolism disease http://purl.obolibrary.org/obo/DOID_445 Bartter disease http://purl.obolibrary.org/obo/DOID_447 renal tubular transport disease http://purl.obolibrary.org/obo/DOID_8672 viral exanthem http://purl.obolibrary.org/obo/DOID_934 viral infectious disease http://purl.obolibrary.org/obo/DOID_758 situs inversus http://purl.obolibrary.org/obo/DOID_0050545 visceral heterotaxy http://purl.obolibrary.org/obo/DOID_11589 Riley-Day syndrome http://purl.obolibrary.org/obo/DOID_0050548 hereditary sensory neuropathy http://purl.obolibrary.org/obo/DOID_3683 lung benign neoplasm http://purl.obolibrary.org/obo/DOID_850 lung disease http://purl.obolibrary.org/obo/DOID_1350 paranasal sinus benign neoplasm http://purl.obolibrary.org/obo/DOID_1352 paranasal sinus disease http://purl.obolibrary.org/obo/DOID_2598 laryngeal benign neoplasm http://purl.obolibrary.org/obo/DOID_786 laryngeal disease http://purl.obolibrary.org/obo/DOID_3906 bronchial benign neoplasm http://purl.obolibrary.org/obo/DOID_1176 bronchial disease http://purl.obolibrary.org/obo/DOID_7333 nephrogenic adenoma of urinary bladder http://purl.obolibrary.org/obo/DOID_657 adenoma http://purl.obolibrary.org/obo/DOID_3918 pancreatic cystadenoma http://purl.obolibrary.org/obo/DOID_26 pancreas disease http://purl.obolibrary.org/obo/DOID_7532 squamous papillomatosis http://purl.obolibrary.org/obo/DOID_0050624 gastrointestinal system benign neoplasm http://purl.obolibrary.org/obo/DOID_308 early myoclonic encephalopathy http://purl.obolibrary.org/obo/DOID_0050702 neonatal period electroclinical syndrome http://purl.obolibrary.org/obo/DOID_2538 Landau-Kleffner syndrome http://purl.obolibrary.org/obo/DOID_0050704 childhood electroclinical syndrome http://purl.obolibrary.org/obo/DOID_3329 benign epilepsy with centrotemporal spikes http://purl.obolibrary.org/obo/DOID_0050704 childhood electroclinical syndrome http://purl.obolibrary.org/obo/DOID_8712 neurofibromatosis http://purl.obolibrary.org/obo/DOID_225 syndrome http://purl.obolibrary.org/obo/DOID_9248 Pallister-Hall syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome http://purl.obolibrary.org/obo/DOID_10041 dysplastic nevus syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome http://purl.obolibrary.org/obo/DOID_14789 spondyloepiphyseal dysplasia congenita http://purl.obolibrary.org/obo/DOID_0080027 spondyloepimetaphyseal dysplasia http://purl.obolibrary.org/obo/DOID_2216 factor V deficiency http://purl.obolibrary.org/obo/DOID_1247 blood coagulation disease http://purl.obolibrary.org/obo/DOID_3613 Canavan disease http://purl.obolibrary.org/obo/DOID_10579 leukodystrophy http://purl.obolibrary.org/obo/DOID_13884 sick sinus syndrome http://purl.obolibrary.org/obo/DOID_0050824 sinoatrial node disease http://purl.obolibrary.org/obo/DOID_5644 tricuspid valve prolapse http://purl.obolibrary.org/obo/DOID_0050826 tricuspid valve disease http://purl.obolibrary.org/obo/DOID_342 subclavian artery aneurysm http://purl.obolibrary.org/obo/DOID_0050828 artery disease http://purl.obolibrary.org/obo/DOID_13095 vertebral artery insufficiency http://purl.obolibrary.org/obo/DOID_225 syndrome http://purl.obolibrary.org/obo/DOID_13446 basilar artery occlusion http://purl.obolibrary.org/obo/DOID_5976 occlusion precerebral artery http://purl.obolibrary.org/obo/DOID_14006 splenic artery aneurysm http://purl.obolibrary.org/obo/DOID_0050828 artery disease http://purl.obolibrary.org/obo/DOID_2388 renal artery disease http://purl.obolibrary.org/obo/DOID_0050828 artery disease http://purl.obolibrary.org/obo/DOID_3407 carotid artery disease http://purl.obolibrary.org/obo/DOID_6713 cerebrovascular disease http://purl.obolibrary.org/obo/DOID_3527 cerebral arterial disease http://purl.obolibrary.org/obo/DOID_13089 intracranial arterial disease http://purl.obolibrary.org/obo/DOID_8483 retinal artery occlusion http://purl.obolibrary.org/obo/DOID_1729 retinal vascular occlusion http://purl.obolibrary.org/obo/DOID_116 pericardium cancer http://purl.obolibrary.org/obo/DOID_117 heart cancer http://purl.obolibrary.org/obo/DOID_1312 focal segmental glomerulosclerosis http://purl.obolibrary.org/obo/DOID_0050851 glomerulosclerosis http://purl.obolibrary.org/obo/DOID_4752 multiple system atrophy http://purl.obolibrary.org/obo/DOID_0050890 synucleinopathy http://purl.obolibrary.org/obo/DOID_3861 medullomyoblastoma http://purl.obolibrary.org/obo/DOID_0050902 medulloblastoma http://purl.obolibrary.org/obo/DOID_3864 adult medulloblastoma http://purl.obolibrary.org/obo/DOID_0050902 medulloblastoma http://purl.obolibrary.org/obo/DOID_3869 childhood medulloblastoma http://purl.obolibrary.org/obo/DOID_0050902 medulloblastoma http://purl.obolibrary.org/obo/DOID_12705 Friedreich ataxia http://purl.obolibrary.org/obo/DOID_0050950 autosomal recessive cerebellar ataxia http://purl.obolibrary.org/obo/DOID_8505 dermatitis herpetiformis http://purl.obolibrary.org/obo/DOID_8502 bullous skin disease http://purl.obolibrary.org/obo/DOID_1876 sexual dysfunction http://purl.obolibrary.org/obo/DOID_0060043 sexual disorder http://purl.obolibrary.org/obo/DOID_10132 psychosexual disorder http://purl.obolibrary.org/obo/DOID_0060043 sexual disorder http://purl.obolibrary.org/obo/DOID_10236 exhibitionism http://purl.obolibrary.org/obo/DOID_0060044 paraphilia disorder http://purl.obolibrary.org/obo/DOID_10834 voyeurism http://purl.obolibrary.org/obo/DOID_0060044 paraphilia disorder http://purl.obolibrary.org/obo/DOID_1235 fetishism http://purl.obolibrary.org/obo/DOID_0060044 paraphilia disorder http://purl.obolibrary.org/obo/DOID_13351 pedophilia http://purl.obolibrary.org/obo/DOID_0060044 paraphilia disorder http://purl.obolibrary.org/obo/DOID_8925 primary thrombocytopenia http://purl.obolibrary.org/obo/DOID_0060050 autoimmune disease of blood http://purl.obolibrary.org/obo/DOID_6547 heart lymphoma http://purl.obolibrary.org/obo/DOID_117 heart cancer http://purl.obolibrary.org/obo/DOID_6760 lung lymphoma http://purl.obolibrary.org/obo/DOID_1324 lung cancer http://purl.obolibrary.org/obo/DOID_8135 gallbladder lymphoma http://purl.obolibrary.org/obo/DOID_3121 gallbladder cancer http://purl.obolibrary.org/obo/DOID_903 gastrointestinal lymphoma http://purl.obolibrary.org/obo/DOID_3119 gastrointestinal system cancer http://purl.obolibrary.org/obo/DOID_10011 thyroid lymphoma http://purl.obolibrary.org/obo/DOID_1781 thyroid gland cancer http://purl.obolibrary.org/obo/DOID_10540 gastric lymphoma http://purl.obolibrary.org/obo/DOID_10534 stomach cancer http://purl.obolibrary.org/obo/DOID_10813 nasal cavity lymphoma http://purl.obolibrary.org/obo/DOID_10811 nasal cavity cancer http://purl.obolibrary.org/obo/DOID_12253 testicular lymphoma http://purl.obolibrary.org/obo/DOID_2998 testicular cancer http://purl.obolibrary.org/obo/DOID_13996 small intestine lymphoma http://purl.obolibrary.org/obo/DOID_10154 small intestine cancer http://purl.obolibrary.org/obo/DOID_8541 Sezary's disease http://purl.obolibrary.org/obo/DOID_0060061 cutaneous T cell lymphoma http://purl.obolibrary.org/obo/DOID_8691 mycosis fungoides http://purl.obolibrary.org/obo/DOID_0060061 cutaneous T cell lymphoma http://purl.obolibrary.org/obo/DOID_8866 actinic keratosis http://purl.obolibrary.org/obo/DOID_0060071 pre-malignant neoplasm http://purl.obolibrary.org/obo/DOID_8538 reticulosarcoma http://purl.obolibrary.org/obo/DOID_0060073 lymphatic system cancer http://purl.obolibrary.org/obo/DOID_3855 seminal vesicle tumor http://purl.obolibrary.org/obo/DOID_0060087 male reproductive organ benign neoplasm http://purl.obolibrary.org/obo/DOID_7675 testicular fibroma http://purl.obolibrary.org/obo/DOID_0060087 male reproductive organ benign neoplasm http://purl.obolibrary.org/obo/DOID_11624 penile benign neoplasm http://purl.obolibrary.org/obo/DOID_1529 penile disease http://purl.obolibrary.org/obo/DOID_1786 adrenal rest tumor http://purl.obolibrary.org/obo/DOID_0060089 endocrine organ benign neoplasm http://purl.obolibrary.org/obo/DOID_5389 oxyphilic adenoma http://purl.obolibrary.org/obo/DOID_0060089 endocrine organ benign neoplasm http://purl.obolibrary.org/obo/DOID_916 liver benign neoplasm http://purl.obolibrary.org/obo/DOID_409 liver disease http://purl.obolibrary.org/obo/DOID_2679 dysembryoplastic neuroepithelial tumor http://purl.obolibrary.org/obo/DOID_0060090 central nervous system benign neoplasm http://purl.obolibrary.org/obo/DOID_3840 craniopharyngioma http://purl.obolibrary.org/obo/DOID_0060090 central nervous system benign neoplasm http://purl.obolibrary.org/obo/DOID_4587 benign meningioma http://purl.obolibrary.org/obo/DOID_0060090 central nervous system benign neoplasm http://purl.obolibrary.org/obo/DOID_5393 brain angioma http://purl.obolibrary.org/obo/DOID_6713 cerebrovascular disease http://purl.obolibrary.org/obo/DOID_5238 benign perivascular tumor http://purl.obolibrary.org/obo/DOID_0060091 cardiovascular organ benign neoplasm http://purl.obolibrary.org/obo/DOID_60006 benign vascular tumor http://purl.obolibrary.org/obo/DOID_0060091 cardiovascular organ benign neoplasm http://purl.obolibrary.org/obo/DOID_200 benign giant cell tumor http://purl.obolibrary.org/obo/DOID_0060094 bone benign neoplasm http://purl.obolibrary.org/obo/DOID_166 melanotic neuroectodermal tumor http://purl.obolibrary.org/obo/DOID_0060094 bone benign neoplasm http://purl.obolibrary.org/obo/DOID_461 muscle benign neoplasm http://purl.obolibrary.org/obo/DOID_0080000 muscular disease http://purl.obolibrary.org/obo/DOID_4844 benign ependymoma http://purl.obolibrary.org/obo/DOID_0060101 benign glioma http://purl.obolibrary.org/obo/DOID_4788 intracranial primitive neuroectodermal tumor http://purl.obolibrary.org/obo/DOID_0060103 central nervous system primitive neuroectodermal neoplasm http://purl.obolibrary.org/obo/DOID_4790 medulloepithelioma http://purl.obolibrary.org/obo/DOID_0060103 central nervous system primitive neuroectodermal neoplasm http://purl.obolibrary.org/obo/DOID_4794 ependymoblastoma http://purl.obolibrary.org/obo/DOID_0060103 central nervous system primitive neuroectodermal neoplasm http://purl.obolibrary.org/obo/DOID_3165 skin benign neoplasm http://purl.obolibrary.org/obo/DOID_37 skin disease http://purl.obolibrary.org/obo/DOID_2701 nodular tenosynovitis http://purl.obolibrary.org/obo/DOID_0060123 connective tissue benign neoplasm http://purl.obolibrary.org/obo/DOID_4231 histiocytoma http://purl.obolibrary.org/obo/DOID_0060123 connective tissue benign neoplasm http://purl.obolibrary.org/obo/DOID_4386 myofibroma http://purl.obolibrary.org/obo/DOID_0060123 connective tissue benign neoplasm http://purl.obolibrary.org/obo/DOID_4260 gait apraxia http://purl.obolibrary.org/obo/DOID_0060135 apraxia http://purl.obolibrary.org/obo/DOID_4627 ideomotor apraxia http://purl.obolibrary.org/obo/DOID_0060135 apraxia http://purl.obolibrary.org/obo/DOID_9714 occlusion of gallbladder http://purl.obolibrary.org/obo/DOID_0060262 gallbladder disease http://purl.obolibrary.org/obo/DOID_10211 cholelithiasis http://purl.obolibrary.org/obo/DOID_0060262 gallbladder disease http://purl.obolibrary.org/obo/DOID_11151 cholecystolithiasis http://purl.obolibrary.org/obo/DOID_0060262 gallbladder disease http://purl.obolibrary.org/obo/DOID_4626 hydranencephaly http://purl.obolibrary.org/obo/DOID_0060668 anencephaly http://purl.obolibrary.org/obo/DOID_66 muscle tissue disease http://purl.obolibrary.org/obo/DOID_0080000 muscular disease http://purl.obolibrary.org/obo/DOID_13357 chondromalacia patellae http://purl.obolibrary.org/obo/DOID_2557 chondromalacia http://purl.obolibrary.org/obo/DOID_1919 Lesch-Nyhan syndrome http://purl.obolibrary.org/obo/DOID_653 purine-pyrimidine metabolic disorder http://purl.obolibrary.org/obo/DOID_11665 Patau syndrome http://purl.obolibrary.org/obo/DOID_0080014 chromosomal disease http://purl.obolibrary.org/obo/DOID_422 congenital structural myopathy http://purl.obolibrary.org/obo/DOID_423 myopathy http://purl.obolibrary.org/obo/DOID_9827 radioulnar synostosis http://purl.obolibrary.org/obo/DOID_0080015 physical disorder http://purl.obolibrary.org/obo/DOID_10488 imperforate anus http://purl.obolibrary.org/obo/DOID_3128 anus disease http://purl.obolibrary.org/obo/DOID_11044 gastroschisis http://purl.obolibrary.org/obo/DOID_0080015 physical disorder http://purl.obolibrary.org/obo/DOID_11367 congenital aphakia http://purl.obolibrary.org/obo/DOID_110 lens disease http://purl.obolibrary.org/obo/DOID_1342 congenital hypoplastic anemia http://purl.obolibrary.org/obo/DOID_12449 aplastic anemia http://purl.obolibrary.org/obo/DOID_14177 congenital hypogammaglobulinemia http://purl.obolibrary.org/obo/DOID_2115 B cell deficiency http://purl.obolibrary.org/obo/DOID_1682 congenital heart disease http://purl.obolibrary.org/obo/DOID_114 heart disease http://purl.obolibrary.org/obo/DOID_2490 congenital nervous system abnormality http://purl.obolibrary.org/obo/DOID_863 nervous system disease http://purl.obolibrary.org/obo/DOID_589 congenital hemolytic anemia http://purl.obolibrary.org/obo/DOID_583 hemolytic anemia http://purl.obolibrary.org/obo/DOID_10020 ampulla of Vater cancer http://purl.obolibrary.org/obo/DOID_4606 bile duct cancer http://purl.obolibrary.org/obo/DOID_1260 parametritis http://purl.obolibrary.org/obo/DOID_1003 pelvic inflammatory disease http://purl.obolibrary.org/obo/DOID_10033 cycloplegia http://purl.obolibrary.org/obo/DOID_10034 eye accommodation disease http://purl.obolibrary.org/obo/DOID_11638 presbyopia http://purl.obolibrary.org/obo/DOID_10034 eye accommodation disease http://purl.obolibrary.org/obo/DOID_3138 acanthosis nigricans http://purl.obolibrary.org/obo/DOID_10123 pigmentation disease http://purl.obolibrary.org/obo/DOID_2283 keratopathy http://purl.obolibrary.org/obo/DOID_10124 corneal disease http://purl.obolibrary.org/obo/DOID_11028 pseudopterygium http://purl.obolibrary.org/obo/DOID_10124 corneal disease http://purl.obolibrary.org/obo/DOID_11030 corneal edema http://purl.obolibrary.org/obo/DOID_10124 corneal disease http://purl.obolibrary.org/obo/DOID_1237 corneal degeneration http://purl.obolibrary.org/obo/DOID_9799 eye degenerative disease http://purl.obolibrary.org/obo/DOID_12753 corneal staphyloma http://purl.obolibrary.org/obo/DOID_10124 corneal disease http://purl.obolibrary.org/obo/DOID_1436 corneal ectasia http://purl.obolibrary.org/obo/DOID_10124 corneal disease http://purl.obolibrary.org/obo/DOID_2566 corneal dystrophy http://purl.obolibrary.org/obo/DOID_10124 corneal disease http://purl.obolibrary.org/obo/DOID_13709 premature ejaculation http://purl.obolibrary.org/obo/DOID_10132 psychosexual disorder http://purl.obolibrary.org/obo/DOID_13868 hypoactive sexual desire disorder http://purl.obolibrary.org/obo/DOID_10132 psychosexual disorder http://purl.obolibrary.org/obo/DOID_11029 pinguecula http://purl.obolibrary.org/obo/DOID_10139 conjunctival degeneration http://purl.obolibrary.org/obo/DOID_10138 xerophthalmia http://purl.obolibrary.org/obo/DOID_10140 dry eye syndrome http://purl.obolibrary.org/obo/DOID_12895 keratoconjunctivitis sicca http://purl.obolibrary.org/obo/DOID_10140 dry eye syndrome http://purl.obolibrary.org/obo/DOID_14202 adult dermatomyositis http://purl.obolibrary.org/obo/DOID_10223 dermatomyositis http://purl.obolibrary.org/obo/DOID_384 Wolff-Parkinson-White syndrome http://purl.obolibrary.org/obo/DOID_10273 heart conduction disease http://purl.obolibrary.org/obo/DOID_13209 right bundle branch block http://purl.obolibrary.org/obo/DOID_10273 heart conduction disease http://purl.obolibrary.org/obo/DOID_7141 prostate small cell carcinoma http://purl.obolibrary.org/obo/DOID_305 carcinoma http://purl.obolibrary.org/obo/DOID_14451 hyperkalemic periodic paralysis http://purl.obolibrary.org/obo/DOID_1029 familial periodic paralysis http://purl.obolibrary.org/obo/DOID_14452 hypokalemic periodic paralysis http://purl.obolibrary.org/obo/DOID_1029 familial periodic paralysis http://purl.obolibrary.org/obo/DOID_10323 byssinosis http://purl.obolibrary.org/obo/DOID_10316 pneumoconiosis http://purl.obolibrary.org/obo/DOID_10327 anthracosis http://purl.obolibrary.org/obo/DOID_10316 pneumoconiosis http://purl.obolibrary.org/obo/DOID_10328 siderosis http://purl.obolibrary.org/obo/DOID_10316 pneumoconiosis http://purl.obolibrary.org/obo/DOID_10375 suppression amblyopia http://purl.obolibrary.org/obo/DOID_10376 amblyopia http://purl.obolibrary.org/obo/DOID_10378 disuse amblyopia http://purl.obolibrary.org/obo/DOID_10376 amblyopia http://purl.obolibrary.org/obo/DOID_9700 bacterial conjunctivitis http://purl.obolibrary.org/obo/DOID_6195 conjunctivitis http://purl.obolibrary.org/obo/DOID_1039 prolymphocytic leukemia http://purl.obolibrary.org/obo/DOID_1040 chronic lymphocytic leukemia http://purl.obolibrary.org/obo/DOID_10480 diaphragmatic eventration http://purl.obolibrary.org/obo/DOID_10481 diaphragm disease http://purl.obolibrary.org/obo/DOID_10548 cardia cancer http://purl.obolibrary.org/obo/DOID_10534 stomach cancer http://purl.obolibrary.org/obo/DOID_6271 gastric cardia adenocarcinoma http://purl.obolibrary.org/obo/DOID_3717 gastric adenocarcinoma http://purl.obolibrary.org/obo/DOID_12678 hypercalcemia http://purl.obolibrary.org/obo/DOID_10575 calcium metabolism disease http://purl.obolibrary.org/obo/DOID_11401 xanthogranulomatous pyelonephritis http://purl.obolibrary.org/obo/DOID_1076 chronic pyelonephritis http://purl.obolibrary.org/obo/DOID_10302 parotid disease http://purl.obolibrary.org/obo/DOID_10854 salivary gland disease http://purl.obolibrary.org/obo/DOID_10303 sialadenitis http://purl.obolibrary.org/obo/DOID_1602 lymphadenitis http://purl.obolibrary.org/obo/DOID_12901 necrotizing sialometaplasia http://purl.obolibrary.org/obo/DOID_10854 salivary gland disease http://purl.obolibrary.org/obo/DOID_12904 mucocele of salivary gland http://purl.obolibrary.org/obo/DOID_10854 salivary gland disease http://purl.obolibrary.org/obo/DOID_1573 communicating hydrocephalus http://purl.obolibrary.org/obo/DOID_10908 hydrocephalus http://purl.obolibrary.org/obo/DOID_4154 dentinogenesis imperfecta http://purl.obolibrary.org/obo/DOID_1091 tooth disease http://purl.obolibrary.org/obo/DOID_13711 dental fluorosis http://purl.obolibrary.org/obo/DOID_1091 tooth disease http://purl.obolibrary.org/obo/DOID_214 teeth hard tissue disease http://purl.obolibrary.org/obo/DOID_1091 tooth disease http://purl.obolibrary.org/obo/DOID_5330 dental pulp disease http://purl.obolibrary.org/obo/DOID_65 connective tissue disease http://purl.obolibrary.org/obo/DOID_11514 fissured tongue http://purl.obolibrary.org/obo/DOID_10944 tongue disease http://purl.obolibrary.org/obo/DOID_1456 glossitis http://purl.obolibrary.org/obo/DOID_10944 tongue disease http://purl.obolibrary.org/obo/DOID_8649 tongue cancer http://purl.obolibrary.org/obo/DOID_8618 oral cavity cancer http://purl.obolibrary.org/obo/DOID_1063 interstitial nephritis http://purl.obolibrary.org/obo/DOID_10952 nephritis http://purl.obolibrary.org/obo/DOID_10972 salpingo-oophoritis http://purl.obolibrary.org/obo/DOID_10974 oophoritis http://purl.obolibrary.org/obo/DOID_11364 lens subluxation http://purl.obolibrary.org/obo/DOID_110 lens disease http://purl.obolibrary.org/obo/DOID_11031 bullous keratopathy http://purl.obolibrary.org/obo/DOID_11030 corneal edema http://purl.obolibrary.org/obo/DOID_11033 idiopathic corneal edema http://purl.obolibrary.org/obo/DOID_11030 corneal edema http://purl.obolibrary.org/obo/DOID_1907 malignant fibrous histiocytoma http://purl.obolibrary.org/obo/DOID_1115 sarcoma http://purl.obolibrary.org/obo/DOID_13576 twin-to-twin transfusion syndrome http://purl.obolibrary.org/obo/DOID_11244 neonatal anemia http://purl.obolibrary.org/obo/DOID_1129 pituitary apoplexy http://purl.obolibrary.org/obo/DOID_1130 pituitary infarct http://purl.obolibrary.org/obo/DOID_13402 skin sarcoidosis http://purl.obolibrary.org/obo/DOID_37 skin disease http://purl.obolibrary.org/obo/DOID_11595 scleral staphyloma http://purl.obolibrary.org/obo/DOID_11343 scleral disease http://purl.obolibrary.org/obo/DOID_13452 scleritis http://purl.obolibrary.org/obo/DOID_11343 scleral disease http://purl.obolibrary.org/obo/DOID_1770 toxic megacolon http://purl.obolibrary.org/obo/DOID_11372 megacolon http://purl.obolibrary.org/obo/DOID_9768 heart aneurysm http://purl.obolibrary.org/obo/DOID_114 heart disease http://purl.obolibrary.org/obo/DOID_1138 spinal meningioma http://purl.obolibrary.org/obo/DOID_3565 meningioma http://purl.obolibrary.org/obo/DOID_1076 chronic pyelonephritis http://purl.obolibrary.org/obo/DOID_11400 pyelonephritis http://purl.obolibrary.org/obo/DOID_11504 autonomic neuropathy http://purl.obolibrary.org/obo/DOID_11465 autonomic nervous system disease http://purl.obolibrary.org/obo/DOID_11599 Frey syndrome http://purl.obolibrary.org/obo/DOID_11465 autonomic nervous system disease http://purl.obolibrary.org/obo/DOID_3223 complex regional pain syndrome http://purl.obolibrary.org/obo/DOID_11465 autonomic nervous system disease http://purl.obolibrary.org/obo/DOID_11486 Horner's syndrome http://purl.obolibrary.org/obo/DOID_11504 autonomic neuropathy http://purl.obolibrary.org/obo/DOID_11914 gastroparesis http://purl.obolibrary.org/obo/DOID_1159 functional gastric disease http://purl.obolibrary.org/obo/DOID_8439 postgastrectomy syndrome http://purl.obolibrary.org/obo/DOID_5295 intestinal disease http://purl.obolibrary.org/obo/DOID_6201 pericardial mesothelioma http://purl.obolibrary.org/obo/DOID_116 pericardium cancer http://purl.obolibrary.org/obo/DOID_1172 hyperlipoproteinemia type IV http://purl.obolibrary.org/obo/DOID_1168 familial hyperlipidemia http://purl.obolibrary.org/obo/DOID_13809 familial combined hyperlipidemia http://purl.obolibrary.org/obo/DOID_1168 familial hyperlipidemia http://purl.obolibrary.org/obo/DOID_11781 regular astigmatism http://purl.obolibrary.org/obo/DOID_11782 astigmatism http://purl.obolibrary.org/obo/DOID_13919 irregular astigmatism http://purl.obolibrary.org/obo/DOID_11782 astigmatism http://purl.obolibrary.org/obo/DOID_12526 tarsal tunnel syndrome http://purl.obolibrary.org/obo/DOID_1187 tibial neuropathy http://purl.obolibrary.org/obo/DOID_1802 mononeuritis http://purl.obolibrary.org/obo/DOID_1188 mononeuropathy http://purl.obolibrary.org/obo/DOID_4201 peroneal neuropathy http://purl.obolibrary.org/obo/DOID_1188 mononeuropathy http://purl.obolibrary.org/obo/DOID_4613 ulnar neuropathy http://purl.obolibrary.org/obo/DOID_1188 mononeuropathy http://purl.obolibrary.org/obo/DOID_1187 tibial neuropathy http://purl.obolibrary.org/obo/DOID_1188 mononeuropathy http://purl.obolibrary.org/obo/DOID_1742 drug psychosis http://purl.obolibrary.org/obo/DOID_1203 drug-induced mental disorder http://purl.obolibrary.org/obo/DOID_1407 anterior uveitis http://purl.obolibrary.org/obo/DOID_12030 panuveitis http://purl.obolibrary.org/obo/DOID_12175 dyshormonogenic goiter http://purl.obolibrary.org/obo/DOID_12176 goiter http://purl.obolibrary.org/obo/DOID_13200 substernal goiter http://purl.obolibrary.org/obo/DOID_12176 goiter http://purl.obolibrary.org/obo/DOID_6227 articular cartilage disease http://purl.obolibrary.org/obo/DOID_1222 cartilage disease http://purl.obolibrary.org/obo/DOID_5284 retroperitoneal leiomyosarcoma http://purl.obolibrary.org/obo/DOID_12341 retroperitoneal sarcoma http://purl.obolibrary.org/obo/DOID_1233 transvestism http://purl.obolibrary.org/obo/DOID_1235 fetishism http://purl.obolibrary.org/obo/DOID_11164 band keratopathy http://purl.obolibrary.org/obo/DOID_1237 corneal degeneration http://purl.obolibrary.org/obo/DOID_11267 keratomalacia http://purl.obolibrary.org/obo/DOID_1237 corneal degeneration http://purl.obolibrary.org/obo/DOID_11541 recurrent corneal erosion http://purl.obolibrary.org/obo/DOID_1237 corneal degeneration http://purl.obolibrary.org/obo/DOID_4873 anterior horn cell disease http://purl.obolibrary.org/obo/DOID_12377 spinal muscular atrophy http://purl.obolibrary.org/obo/DOID_13113 cicatricial entropion http://purl.obolibrary.org/obo/DOID_12397 entropion http://purl.obolibrary.org/obo/DOID_14070 vestibular nystagmus http://purl.obolibrary.org/obo/DOID_1242 globe disease http://purl.obolibrary.org/obo/DOID_1340 pure red-cell aplasia http://purl.obolibrary.org/obo/DOID_12449 aplastic anemia http://purl.obolibrary.org/obo/DOID_2213 hemorrhagic disease http://purl.obolibrary.org/obo/DOID_1247 blood coagulation disease http://purl.obolibrary.org/obo/DOID_12934 Kearns-Sayre syndrome http://purl.obolibrary.org/obo/DOID_12558 chronic progressive external ophthalmoplegia http://purl.obolibrary.org/obo/DOID_1829 urethral stricture http://purl.obolibrary.org/obo/DOID_12577 urethral obstruction http://purl.obolibrary.org/obo/DOID_12668 abnormal retinal correspondence http://purl.obolibrary.org/obo/DOID_12667 binocular vision disease http://purl.obolibrary.org/obo/DOID_2493 gastric antral vascular ectasia http://purl.obolibrary.org/obo/DOID_1271 capillary disease http://purl.obolibrary.org/obo/DOID_2725 capillary hemangioma http://purl.obolibrary.org/obo/DOID_1271 capillary disease http://purl.obolibrary.org/obo/DOID_14400 capillary leak syndrome http://purl.obolibrary.org/obo/DOID_1271 capillary disease http://purl.obolibrary.org/obo/DOID_1278 tolosa-hunt syndrome http://purl.obolibrary.org/obo/DOID_1279 ocular motility disease http://purl.obolibrary.org/obo/DOID_539 ophthalmoplegia http://purl.obolibrary.org/obo/DOID_1279 ocular motility disease http://purl.obolibrary.org/obo/DOID_9650 pathologic nystagmus http://purl.obolibrary.org/obo/DOID_1279 ocular motility disease http://purl.obolibrary.org/obo/DOID_9307 rectal prolapse http://purl.obolibrary.org/obo/DOID_1285 rectal disease http://purl.obolibrary.org/obo/DOID_3128 anus disease http://purl.obolibrary.org/obo/DOID_1285 rectal disease http://purl.obolibrary.org/obo/DOID_11870 Pick's disease http://purl.obolibrary.org/obo/DOID_1289 neurodegenerative disease http://purl.obolibrary.org/obo/DOID_1227 neutropenia http://purl.obolibrary.org/obo/DOID_12987 agranulocytosis http://purl.obolibrary.org/obo/DOID_13120 protein-deficiency anemia http://purl.obolibrary.org/obo/DOID_13121 deficiency anemia http://purl.obolibrary.org/obo/DOID_13139 crescentic glomerulonephritis http://purl.obolibrary.org/obo/DOID_13138 acute proliferative glomerulonephritis http://purl.obolibrary.org/obo/DOID_14550 root resorption http://purl.obolibrary.org/obo/DOID_13240 tooth resorption http://purl.obolibrary.org/obo/DOID_13271 cutaneous porphyria http://purl.obolibrary.org/obo/DOID_37 skin disease http://purl.obolibrary.org/obo/DOID_13910 red color blindness http://purl.obolibrary.org/obo/DOID_13399 color blindness http://purl.obolibrary.org/obo/DOID_1361 frontal sinus benign neoplasm http://purl.obolibrary.org/obo/DOID_1350 paranasal sinus benign neoplasm http://purl.obolibrary.org/obo/DOID_8060 frontal sinus inverted papilloma http://purl.obolibrary.org/obo/DOID_2615 papilloma http://purl.obolibrary.org/obo/DOID_5166 endometrial stromal tumor http://purl.obolibrary.org/obo/DOID_1380 endometrial cancer http://purl.obolibrary.org/obo/DOID_2095 sweat gland cancer http://purl.obolibrary.org/obo/DOID_4159 skin cancer http://purl.obolibrary.org/obo/DOID_2664 sweat gland benign neoplasm http://purl.obolibrary.org/obo/DOID_3165 skin benign neoplasm http://purl.obolibrary.org/obo/DOID_1388 Tangier disease http://purl.obolibrary.org/obo/DOID_1387 hypolipoproteinemia http://purl.obolibrary.org/obo/DOID_1391 Norum disease http://purl.obolibrary.org/obo/DOID_1387 hypolipoproteinemia http://purl.obolibrary.org/obo/DOID_5214 demyelinating polyneuropathy http://purl.obolibrary.org/obo/DOID_1389 polyneuropathy http://purl.obolibrary.org/obo/DOID_5221 chronic polyneuropathy http://purl.obolibrary.org/obo/DOID_1389 polyneuropathy http://purl.obolibrary.org/obo/DOID_1392 pseudopapilledema http://purl.obolibrary.org/obo/DOID_1393 visual pathway disease http://purl.obolibrary.org/obo/DOID_5691 visual cortex disease http://purl.obolibrary.org/obo/DOID_1393 visual pathway disease http://purl.obolibrary.org/obo/DOID_6970 acute inflammation of lacrimal passage http://purl.obolibrary.org/obo/DOID_1400 lacrimal apparatus disease http://purl.obolibrary.org/obo/DOID_13757 excessive tearing http://purl.obolibrary.org/obo/DOID_1400 lacrimal apparatus disease http://purl.obolibrary.org/obo/DOID_13929 lacrimal duct obstruction http://purl.obolibrary.org/obo/DOID_1400 lacrimal apparatus disease http://purl.obolibrary.org/obo/DOID_950 dacryoadenitis http://purl.obolibrary.org/obo/DOID_1400 lacrimal apparatus disease http://purl.obolibrary.org/obo/DOID_9383 iridocyclitis http://purl.obolibrary.org/obo/DOID_1407 anterior uveitis http://purl.obolibrary.org/obo/DOID_980 choroidal sclerosis http://purl.obolibrary.org/obo/DOID_9799 eye degenerative disease http://purl.obolibrary.org/obo/DOID_9821 choroideremia http://purl.obolibrary.org/obo/DOID_1417 choroid disease http://purl.obolibrary.org/obo/DOID_12759 choroid cancer http://purl.obolibrary.org/obo/DOID_3479 uveal cancer http://purl.obolibrary.org/obo/DOID_1415 gyrate atrophy http://purl.obolibrary.org/obo/DOID_1417 choroid disease http://purl.obolibrary.org/obo/DOID_5199 ureteral obstruction http://purl.obolibrary.org/obo/DOID_5200 urinary tract obstruction http://purl.obolibrary.org/obo/DOID_11885 ureteral benign neoplasm http://purl.obolibrary.org/obo/DOID_731 urinary system benign neoplasm http://purl.obolibrary.org/obo/DOID_6977 pancreatic cholera http://purl.obolibrary.org/obo/DOID_1428 endocrine pancreas disease http://purl.obolibrary.org/obo/DOID_2367 neuroaxonal dystrophy http://purl.obolibrary.org/obo/DOID_1443 cerebral degeneration http://purl.obolibrary.org/obo/DOID_10742 cerebral lipidosis http://purl.obolibrary.org/obo/DOID_1443 cerebral degeneration http://purl.obolibrary.org/obo/DOID_14111 median rhomboid glossitis http://purl.obolibrary.org/obo/DOID_1456 glossitis http://purl.obolibrary.org/obo/DOID_11633 thyroid hormone resistance syndrome http://purl.obolibrary.org/obo/DOID_1459 hypothyroidism http://purl.obolibrary.org/obo/DOID_3081 cystic lymphangioma http://purl.obolibrary.org/obo/DOID_1475 lymphangioma http://purl.obolibrary.org/obo/DOID_1134 gingival recession http://purl.obolibrary.org/obo/DOID_1483 gingival disease http://purl.obolibrary.org/obo/DOID_3086 gingival overgrowth http://purl.obolibrary.org/obo/DOID_1483 gingival disease http://purl.obolibrary.org/obo/DOID_3087 gingivitis http://purl.obolibrary.org/obo/DOID_1483 gingival disease http://purl.obolibrary.org/obo/DOID_5223 infertility http://purl.obolibrary.org/obo/DOID_15 reproductive system disease http://purl.obolibrary.org/obo/DOID_2712 phimosis http://purl.obolibrary.org/obo/DOID_1529 penile disease http://purl.obolibrary.org/obo/DOID_8616 Peyronie's disease http://purl.obolibrary.org/obo/DOID_1529 penile disease http://purl.obolibrary.org/obo/DOID_11615 penile cancer http://purl.obolibrary.org/obo/DOID_3856 male reproductive organ cancer http://purl.obolibrary.org/obo/DOID_13033 balanitis http://purl.obolibrary.org/obo/DOID_1529 penile disease http://purl.obolibrary.org/obo/DOID_12782 cicatricial ectropion http://purl.obolibrary.org/obo/DOID_1570 ectropion http://purl.obolibrary.org/obo/DOID_1572 normal pressure hydrocephalus http://purl.obolibrary.org/obo/DOID_1573 communicating hydrocephalus http://purl.obolibrary.org/obo/DOID_1587 thrombocytopenia due to platelet alloimmunization http://purl.obolibrary.org/obo/DOID_1588 thrombocytopenia http://purl.obolibrary.org/obo/DOID_2848 melancholia http://purl.obolibrary.org/obo/DOID_1596 mental depression http://purl.obolibrary.org/obo/DOID_4637 cervical adenitis http://purl.obolibrary.org/obo/DOID_1602 lymphadenitis http://purl.obolibrary.org/obo/DOID_4639 suppurative lymphadenitis http://purl.obolibrary.org/obo/DOID_1602 lymphadenitis http://purl.obolibrary.org/obo/DOID_2734 keratosis follicularis http://purl.obolibrary.org/obo/DOID_161 keratosis http://purl.obolibrary.org/obo/DOID_6498 seborrheic keratosis http://purl.obolibrary.org/obo/DOID_3165 skin benign neoplasm http://purl.obolibrary.org/obo/DOID_6406 double outlet right ventricle http://purl.obolibrary.org/obo/DOID_1657 ventricular septal defect http://purl.obolibrary.org/obo/DOID_3843 diencephalic neoplasm http://purl.obolibrary.org/obo/DOID_1659 supratentorial cancer http://purl.obolibrary.org/obo/DOID_4791 supratentorial primitive neuroectodermal tumor http://purl.obolibrary.org/obo/DOID_1659 supratentorial cancer http://purl.obolibrary.org/obo/DOID_13507 trigonitis http://purl.obolibrary.org/obo/DOID_1679 cystitis http://purl.obolibrary.org/obo/DOID_13949 interstitial cystitis http://purl.obolibrary.org/obo/DOID_1679 cystitis http://purl.obolibrary.org/obo/DOID_6419 tetralogy of Fallot http://purl.obolibrary.org/obo/DOID_1682 congenital heart disease http://purl.obolibrary.org/obo/DOID_9565 dextrocardia http://purl.obolibrary.org/obo/DOID_1682 congenital heart disease http://purl.obolibrary.org/obo/DOID_13832 patent ductus arteriosus http://purl.obolibrary.org/obo/DOID_1682 congenital heart disease http://purl.obolibrary.org/obo/DOID_1681 heart septal defect http://purl.obolibrary.org/obo/DOID_1682 congenital heart disease http://purl.obolibrary.org/obo/DOID_4430 somatostatinoma http://purl.obolibrary.org/obo/DOID_169 neuroendocrine tumor http://purl.obolibrary.org/obo/DOID_5574 VIPoma http://purl.obolibrary.org/obo/DOID_169 neuroendocrine tumor http://purl.obolibrary.org/obo/DOID_2450 central retinal vein occlusion http://purl.obolibrary.org/obo/DOID_1727 retinal vein occlusion http://purl.obolibrary.org/obo/DOID_5442 eccrine acrospiroma http://purl.obolibrary.org/obo/DOID_173 eccrine sweat gland neoplasm http://purl.obolibrary.org/obo/DOID_4323 epidermolytic acanthoma http://purl.obolibrary.org/obo/DOID_174 acanthoma http://purl.obolibrary.org/obo/DOID_3316 perivascular tumor http://purl.obolibrary.org/obo/DOID_175 vascular cancer http://purl.obolibrary.org/obo/DOID_1757 facial hemiatrophy http://purl.obolibrary.org/obo/DOID_1756 facial nerve disease http://purl.obolibrary.org/obo/DOID_1761 Melkersson-Rosenthal syndrome http://purl.obolibrary.org/obo/DOID_1756 facial nerve disease http://purl.obolibrary.org/obo/DOID_13934 facial paralysis http://purl.obolibrary.org/obo/DOID_1756 facial nerve disease http://purl.obolibrary.org/obo/DOID_2462 retinal vascular disease http://purl.obolibrary.org/obo/DOID_5679 retinal disease http://purl.obolibrary.org/obo/DOID_11481 constrictive pericarditis http://purl.obolibrary.org/obo/DOID_1787 pericarditis http://purl.obolibrary.org/obo/DOID_1439 pyuria http://purl.obolibrary.org/obo/DOID_18 urinary system disease http://purl.obolibrary.org/obo/DOID_5200 urinary tract obstruction http://purl.obolibrary.org/obo/DOID_18 urinary system disease http://purl.obolibrary.org/obo/DOID_11832 visual epilepsy http://purl.obolibrary.org/obo/DOID_1826 epilepsy http://purl.obolibrary.org/obo/DOID_1863 skull cancer http://purl.obolibrary.org/obo/DOID_184 bone cancer http://purl.obolibrary.org/obo/DOID_13620 patent foramen ovale http://purl.obolibrary.org/obo/DOID_1882 atrial heart septal defect http://purl.obolibrary.org/obo/DOID_3419 optic nerve neoplasm http://purl.obolibrary.org/obo/DOID_338 cranial nerve neoplasm http://purl.obolibrary.org/obo/DOID_705 Leber hereditary optic neuropathy http://purl.obolibrary.org/obo/DOID_1891 optic nerve disease http://purl.obolibrary.org/obo/DOID_12010 anterior ischemic optic neuropathy http://purl.obolibrary.org/obo/DOID_1891 optic nerve disease http://purl.obolibrary.org/obo/DOID_13561 optic disk drusen http://purl.obolibrary.org/obo/DOID_1891 optic nerve disease http://purl.obolibrary.org/obo/DOID_146 papilledema http://purl.obolibrary.org/obo/DOID_1891 optic nerve disease http://purl.obolibrary.org/obo/DOID_6846 familial melanoma http://purl.obolibrary.org/obo/DOID_1909 melanoma http://purl.obolibrary.org/obo/DOID_7206 melanomatosis http://purl.obolibrary.org/obo/DOID_1909 melanoma http://purl.obolibrary.org/obo/DOID_8167 gallbladder melanoma http://purl.obolibrary.org/obo/DOID_3121 gallbladder cancer http://purl.obolibrary.org/obo/DOID_3763 hermaphroditism http://purl.obolibrary.org/obo/DOID_1923 disorder of sexual development http://purl.obolibrary.org/obo/DOID_11383 cryptorchidism http://purl.obolibrary.org/obo/DOID_1923 disorder of sexual development http://purl.obolibrary.org/obo/DOID_11613 hyperandrogenism http://purl.obolibrary.org/obo/DOID_1923 disorder of sexual development http://purl.obolibrary.org/obo/DOID_3765 pseudohermaphroditism http://purl.obolibrary.org/obo/DOID_1923 disorder of sexual development http://purl.obolibrary.org/obo/DOID_10587 Krabbe disease http://purl.obolibrary.org/obo/DOID_1927 sphingolipidosis http://purl.obolibrary.org/obo/DOID_10230 aortic atherosclerosis http://purl.obolibrary.org/obo/DOID_1936 atherosclerosis http://purl.obolibrary.org/obo/DOID_12720 cerebral atherosclerosis http://purl.obolibrary.org/obo/DOID_1936 atherosclerosis http://purl.obolibrary.org/obo/DOID_2006 preretinal fibrosis http://purl.obolibrary.org/obo/DOID_2007 degeneration of macula and posterior pole http://purl.obolibrary.org/obo/DOID_10873 Kuhnt-Junius degeneration http://purl.obolibrary.org/obo/DOID_2007 degeneration of macula and posterior pole http://purl.obolibrary.org/obo/DOID_2569 retinal drusen http://purl.obolibrary.org/obo/DOID_2007 degeneration of macula and posterior pole http://purl.obolibrary.org/obo/DOID_2668 mesenchymoma http://purl.obolibrary.org/obo/DOID_201 connective tissue cancer http://purl.obolibrary.org/obo/DOID_2706 synovium cancer http://purl.obolibrary.org/obo/DOID_201 connective tissue cancer http://purl.obolibrary.org/obo/DOID_3939 lipomatous cancer http://purl.obolibrary.org/obo/DOID_201 connective tissue cancer http://purl.obolibrary.org/obo/DOID_13088 periventricular leukomalacia http://purl.obolibrary.org/obo/DOID_2034 encephalomalacia http://purl.obolibrary.org/obo/DOID_693 dental enamel hypoplasia http://purl.obolibrary.org/obo/DOID_214 teeth hard tissue disease http://purl.obolibrary.org/obo/DOID_698 dentin sensitivity http://purl.obolibrary.org/obo/DOID_214 teeth hard tissue disease http://purl.obolibrary.org/obo/DOID_12733 hypercementosis http://purl.obolibrary.org/obo/DOID_214 teeth hard tissue disease http://purl.obolibrary.org/obo/DOID_13240 tooth resorption http://purl.obolibrary.org/obo/DOID_214 teeth hard tissue disease http://purl.obolibrary.org/obo/DOID_2498 tooth erosion http://purl.obolibrary.org/obo/DOID_214 teeth hard tissue disease http://purl.obolibrary.org/obo/DOID_217 enamel caries http://purl.obolibrary.org/obo/DOID_216 dental caries http://purl.obolibrary.org/obo/DOID_10461 dentin caries http://purl.obolibrary.org/obo/DOID_216 dental caries http://purl.obolibrary.org/obo/DOID_14089 root caries http://purl.obolibrary.org/obo/DOID_216 dental caries http://purl.obolibrary.org/obo/DOID_9574 choanal atresia http://purl.obolibrary.org/obo/DOID_2163 nasal cavity disease http://purl.obolibrary.org/obo/DOID_218 ascending colon cancer http://purl.obolibrary.org/obo/DOID_219 colon cancer http://purl.obolibrary.org/obo/DOID_12192 sigmoid colon cancer http://purl.obolibrary.org/obo/DOID_219 colon cancer http://purl.obolibrary.org/obo/DOID_484 vascular hemostatic disease http://purl.obolibrary.org/obo/DOID_2213 hemorrhagic disease http://purl.obolibrary.org/obo/DOID_3326 purpura http://purl.obolibrary.org/obo/DOID_2213 hemorrhagic disease http://purl.obolibrary.org/obo/DOID_2223 platelet storage pool deficiency http://purl.obolibrary.org/obo/DOID_2218 blood platelet disease http://purl.obolibrary.org/obo/DOID_12382 complex partial epilepsy http://purl.obolibrary.org/obo/DOID_2234 focal epilepsy http://purl.obolibrary.org/obo/DOID_12351 alcoholic hepatitis http://purl.obolibrary.org/obo/DOID_2237 hepatitis http://purl.obolibrary.org/obo/DOID_13003 vertebrobasilar insufficiency http://purl.obolibrary.org/obo/DOID_224 transient cerebral ischemia http://purl.obolibrary.org/obo/DOID_13002 subclavian steal syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome http://purl.obolibrary.org/obo/DOID_13677 SAPHO syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome http://purl.obolibrary.org/obo/DOID_14283 primary hypertrophic osteoarthropathy http://purl.obolibrary.org/obo/DOID_225 syndrome http://purl.obolibrary.org/obo/DOID_318 progressive muscular atrophy http://purl.obolibrary.org/obo/DOID_231 motor neuron disease http://purl.obolibrary.org/obo/DOID_681 progressive bulbar palsy http://purl.obolibrary.org/obo/DOID_231 motor neuron disease http://purl.obolibrary.org/obo/DOID_2344 polyclonal hypergammaglobulinemia http://purl.obolibrary.org/obo/DOID_2345 plasma protein metabolism disease http://purl.obolibrary.org/obo/DOID_9080 macroglobulinemia http://purl.obolibrary.org/obo/DOID_2345 plasma protein metabolism disease http://purl.obolibrary.org/obo/DOID_2348 arteriosclerotic cardiovascular disease http://purl.obolibrary.org/obo/DOID_2349 arteriosclerosis http://purl.obolibrary.org/obo/DOID_3669 intermittent claudication http://purl.obolibrary.org/obo/DOID_2349 arteriosclerosis http://purl.obolibrary.org/obo/DOID_5160 arteriosclerosis obliterans http://purl.obolibrary.org/obo/DOID_2349 arteriosclerosis http://purl.obolibrary.org/obo/DOID_720 normocytic anemia http://purl.obolibrary.org/obo/DOID_2355 anemia http://purl.obolibrary.org/obo/DOID_11244 neonatal anemia http://purl.obolibrary.org/obo/DOID_2355 anemia http://purl.obolibrary.org/obo/DOID_11759 hypochromic anemia http://purl.obolibrary.org/obo/DOID_2355 anemia http://purl.obolibrary.org/obo/DOID_13121 deficiency anemia http://purl.obolibrary.org/obo/DOID_2355 anemia http://purl.obolibrary.org/obo/DOID_2361 macrocytic anemia http://purl.obolibrary.org/obo/DOID_2355 anemia http://purl.obolibrary.org/obo/DOID_1406 iritis http://purl.obolibrary.org/obo/DOID_240 iris disease http://purl.obolibrary.org/obo/DOID_2451 protein S deficiency http://purl.obolibrary.org/obo/DOID_620 blood protein disease http://purl.obolibrary.org/obo/DOID_10772 thrombotic thrombocytopenic purpura http://purl.obolibrary.org/obo/DOID_2452 thrombophilia http://purl.obolibrary.org/obo/DOID_11247 disseminated intravascular coagulation http://purl.obolibrary.org/obo/DOID_2452 thrombophilia http://purl.obolibrary.org/obo/DOID_7736 retinal telangiectasia http://purl.obolibrary.org/obo/DOID_2462 retinal vascular disease http://purl.obolibrary.org/obo/DOID_1729 retinal vascular occlusion http://purl.obolibrary.org/obo/DOID_341 peripheral vascular disease http://purl.obolibrary.org/obo/DOID_8947 diabetic retinopathy http://purl.obolibrary.org/obo/DOID_2462 retinal vascular disease http://purl.obolibrary.org/obo/DOID_8646 substance-induced psychosis http://purl.obolibrary.org/obo/DOID_2468 psychotic disorder http://purl.obolibrary.org/obo/DOID_2497 enamel erosion http://purl.obolibrary.org/obo/DOID_2498 tooth erosion http://purl.obolibrary.org/obo/DOID_13629 dentine erosion http://purl.obolibrary.org/obo/DOID_2498 tooth erosion http://purl.obolibrary.org/obo/DOID_2518 orchitis http://purl.obolibrary.org/obo/DOID_2519 testicular disease http://purl.obolibrary.org/obo/DOID_11994 atrophy of testis http://purl.obolibrary.org/obo/DOID_2519 testicular disease http://purl.obolibrary.org/obo/DOID_11996 spermatic cord torsion http://purl.obolibrary.org/obo/DOID_2519 testicular disease http://purl.obolibrary.org/obo/DOID_2530 splenic abscess http://purl.obolibrary.org/obo/DOID_2529 splenic disease http://purl.obolibrary.org/obo/DOID_2533 splenic infarction http://purl.obolibrary.org/obo/DOID_2529 splenic disease http://purl.obolibrary.org/obo/DOID_6376 hypersplenism http://purl.obolibrary.org/obo/DOID_2529 splenic disease http://purl.obolibrary.org/obo/DOID_11786 splenic sequestration http://purl.obolibrary.org/obo/DOID_2529 splenic disease http://purl.obolibrary.org/obo/DOID_8683 myeloid sarcoma http://purl.obolibrary.org/obo/DOID_2531 hematologic cancer http://purl.obolibrary.org/obo/DOID_2536 chronic inflammatory demyelinating polyneuritis http://purl.obolibrary.org/obo/DOID_2537 inflammatory and toxic neuropathy http://purl.obolibrary.org/obo/DOID_14183 alcoholic neuropathy http://purl.obolibrary.org/obo/DOID_2537 inflammatory and toxic neuropathy http://purl.obolibrary.org/obo/DOID_495 sclerosing hemangioma http://purl.obolibrary.org/obo/DOID_255 hemangioma http://purl.obolibrary.org/obo/DOID_496 spindle cell hemangioma http://purl.obolibrary.org/obo/DOID_255 hemangioma http://purl.obolibrary.org/obo/DOID_471 skin hemangioma http://purl.obolibrary.org/obo/DOID_3165 skin benign neoplasm http://purl.obolibrary.org/obo/DOID_474 histiocytoid hemangioma http://purl.obolibrary.org/obo/DOID_255 hemangioma http://purl.obolibrary.org/obo/DOID_5241 hemangioblastoma http://purl.obolibrary.org/obo/DOID_255 hemangioma http://purl.obolibrary.org/obo/DOID_625 transient hypogammaglobulinemia http://purl.obolibrary.org/obo/DOID_2583 agammaglobulinemia http://purl.obolibrary.org/obo/DOID_2595 glottis cancer http://purl.obolibrary.org/obo/DOID_2596 larynx cancer http://purl.obolibrary.org/obo/DOID_10069 subglottis neoplasm http://purl.obolibrary.org/obo/DOID_2598 laryngeal benign neoplasm http://purl.obolibrary.org/obo/DOID_2018 hyperinsulinism http://purl.obolibrary.org/obo/DOID_4194 glucose metabolism disease http://purl.obolibrary.org/obo/DOID_4989 pancreatitis http://purl.obolibrary.org/obo/DOID_26 pancreas disease http://purl.obolibrary.org/obo/DOID_10610 pancreatic steatorrhea http://purl.obolibrary.org/obo/DOID_26 pancreas disease http://purl.obolibrary.org/obo/DOID_12388 neurohypophyseal diabetes insipidus http://purl.obolibrary.org/obo/DOID_26 pancreas disease http://purl.obolibrary.org/obo/DOID_13316 exocrine pancreatic insufficiency http://purl.obolibrary.org/obo/DOID_26 pancreas disease http://purl.obolibrary.org/obo/DOID_1428 endocrine pancreas disease http://purl.obolibrary.org/obo/DOID_26 pancreas disease http://purl.obolibrary.org/obo/DOID_2626 choroid plexus papilloma http://purl.obolibrary.org/obo/DOID_60007 cerebrovascular benign neoplasm http://purl.obolibrary.org/obo/DOID_3177 verrucous papilloma http://purl.obolibrary.org/obo/DOID_2615 papilloma http://purl.obolibrary.org/obo/DOID_3178 skin papilloma http://purl.obolibrary.org/obo/DOID_3165 skin benign neoplasm http://purl.obolibrary.org/obo/DOID_3179 inverted papilloma http://purl.obolibrary.org/obo/DOID_2615 papilloma http://purl.obolibrary.org/obo/DOID_5433 urinary tract papillary transitional cell benign neoplasm http://purl.obolibrary.org/obo/DOID_731 urinary system benign neoplasm http://purl.obolibrary.org/obo/DOID_139 squamous cell papilloma http://purl.obolibrary.org/obo/DOID_2615 papilloma http://purl.obolibrary.org/obo/DOID_1627 intraductal papilloma http://purl.obolibrary.org/obo/DOID_3013 intraductal breast benign neoplasm http://purl.obolibrary.org/obo/DOID_2065 syringoma http://purl.obolibrary.org/obo/DOID_2664 sweat gland benign neoplasm http://purl.obolibrary.org/obo/DOID_5876 apocrine sweat gland neoplasm http://purl.obolibrary.org/obo/DOID_2664 sweat gland benign neoplasm http://purl.obolibrary.org/obo/DOID_173 eccrine sweat gland neoplasm http://purl.obolibrary.org/obo/DOID_2664 sweat gland benign neoplasm http://purl.obolibrary.org/obo/DOID_2702 pigmented villonodular synovitis http://purl.obolibrary.org/obo/DOID_2703 synovitis http://purl.obolibrary.org/obo/DOID_914 peliosis hepatis http://purl.obolibrary.org/obo/DOID_272 hepatic vascular disease http://purl.obolibrary.org/obo/DOID_10762 portal hypertension http://purl.obolibrary.org/obo/DOID_272 hepatic vascular disease http://purl.obolibrary.org/obo/DOID_11512 Budd-Chiari syndrome http://purl.obolibrary.org/obo/DOID_272 hepatic vascular disease http://purl.obolibrary.org/obo/DOID_2773 contact dermatitis http://purl.obolibrary.org/obo/DOID_2723 dermatitis http://purl.obolibrary.org/obo/DOID_4398 pustulosis of palm and sole http://purl.obolibrary.org/obo/DOID_2723 dermatitis http://purl.obolibrary.org/obo/DOID_4399 acneiform dermatitis http://purl.obolibrary.org/obo/DOID_2723 dermatitis http://purl.obolibrary.org/obo/DOID_9165 neurotic excoriation http://purl.obolibrary.org/obo/DOID_2723 dermatitis http://purl.obolibrary.org/obo/DOID_11330 erysipelas http://purl.obolibrary.org/obo/DOID_2723 dermatitis http://purl.obolibrary.org/obo/DOID_379 external ear disease http://purl.obolibrary.org/obo/DOID_2742 auditory system disease http://purl.obolibrary.org/obo/DOID_2889 retrocochlear disease http://purl.obolibrary.org/obo/DOID_2742 auditory system disease http://purl.obolibrary.org/obo/DOID_2952 inner ear disease http://purl.obolibrary.org/obo/DOID_2742 auditory system disease http://purl.obolibrary.org/obo/DOID_5100 middle ear disease http://purl.obolibrary.org/obo/DOID_2742 auditory system disease http://purl.obolibrary.org/obo/DOID_11400 pyelonephritis http://purl.obolibrary.org/obo/DOID_2744 pyelitis http://purl.obolibrary.org/obo/DOID_2746 glycogen storage disease V http://purl.obolibrary.org/obo/DOID_2747 glycogen storage disease http://purl.obolibrary.org/obo/DOID_2750 glycogen storage disease IV http://purl.obolibrary.org/obo/DOID_2747 glycogen storage disease http://purl.obolibrary.org/obo/DOID_4205 cerebellum cancer http://purl.obolibrary.org/obo/DOID_4706 infratentorial cancer http://purl.obolibrary.org/obo/DOID_9072 lethal midline granuloma http://purl.obolibrary.org/obo/DOID_2825 nose disease http://purl.obolibrary.org/obo/DOID_1352 paranasal sinus disease http://purl.obolibrary.org/obo/DOID_2825 nose disease http://purl.obolibrary.org/obo/DOID_2163 nasal cavity disease http://purl.obolibrary.org/obo/DOID_2825 nose disease http://purl.obolibrary.org/obo/DOID_5379 hemoglobin E disease http://purl.obolibrary.org/obo/DOID_2860 hemoglobinopathy http://purl.obolibrary.org/obo/DOID_10783 methemoglobinemia http://purl.obolibrary.org/obo/DOID_2860 hemoglobinopathy http://purl.obolibrary.org/obo/DOID_12657 vestibulocochlear nerve disease http://purl.obolibrary.org/obo/DOID_5656 cranial nerve disease http://purl.obolibrary.org/obo/DOID_294 lacrimal gland cancer http://purl.obolibrary.org/obo/DOID_292 lacrimal system cancer http://purl.obolibrary.org/obo/DOID_2920 membranoproliferative glomerulonephritis http://purl.obolibrary.org/obo/DOID_2921 glomerulonephritis http://purl.obolibrary.org/obo/DOID_10976 membranous glomerulonephritis http://purl.obolibrary.org/obo/DOID_2921 glomerulonephritis http://purl.obolibrary.org/obo/DOID_13138 acute proliferative glomerulonephritis http://purl.obolibrary.org/obo/DOID_2921 glomerulonephritis http://purl.obolibrary.org/obo/DOID_14064 acute poststreptococcal glomerulonephritis http://purl.obolibrary.org/obo/DOID_2921 glomerulonephritis http://purl.obolibrary.org/obo/DOID_4781 diffuse glomerulonephritis http://purl.obolibrary.org/obo/DOID_2921 glomerulonephritis http://purl.obolibrary.org/obo/DOID_2951 motion sickness http://purl.obolibrary.org/obo/DOID_2952 inner ear disease http://purl.obolibrary.org/obo/DOID_10003 sensorineural hearing loss http://purl.obolibrary.org/obo/DOID_2952 inner ear disease http://purl.obolibrary.org/obo/DOID_3426 vestibular disease http://purl.obolibrary.org/obo/DOID_2952 inner ear disease http://purl.obolibrary.org/obo/DOID_566 labyrinthine dysfunction http://purl.obolibrary.org/obo/DOID_2952 inner ear disease http://purl.obolibrary.org/obo/DOID_9868 intestinal disaccharidase deficiency http://purl.obolibrary.org/obo/DOID_5295 intestinal disease http://purl.obolibrary.org/obo/DOID_9869 hereditary fructose intolerance syndrome http://purl.obolibrary.org/obo/DOID_2978 carbohydrate metabolic disorder http://purl.obolibrary.org/obo/DOID_10604 lactose intolerance http://purl.obolibrary.org/obo/DOID_2978 carbohydrate metabolic disorder http://purl.obolibrary.org/obo/DOID_12286 testicular leukemia http://purl.obolibrary.org/obo/DOID_2998 testicular cancer http://purl.obolibrary.org/obo/DOID_3774 chordoid glioma http://purl.obolibrary.org/obo/DOID_3070 malignant glioma http://purl.obolibrary.org/obo/DOID_4848 cerebellar astrocytoma http://purl.obolibrary.org/obo/DOID_4205 cerebellum cancer http://purl.obolibrary.org/obo/DOID_5076 mixed glioma http://purl.obolibrary.org/obo/DOID_3070 malignant glioma http://purl.obolibrary.org/obo/DOID_3181 oligodendroglioma http://purl.obolibrary.org/obo/DOID_3070 malignant glioma http://purl.obolibrary.org/obo/DOID_5337 epulis http://purl.obolibrary.org/obo/DOID_3086 gingival overgrowth http://purl.obolibrary.org/obo/DOID_171 neuroectodermal tumor http://purl.obolibrary.org/obo/DOID_3093 nervous system cancer http://purl.obolibrary.org/obo/DOID_2697 renal adenoma http://purl.obolibrary.org/obo/DOID_657 adenoma http://purl.obolibrary.org/obo/DOID_2698 nephrogenic adenofibroma http://purl.obolibrary.org/obo/DOID_3116 kidney benign neoplasm http://purl.obolibrary.org/obo/DOID_6245 renal oncocytoma http://purl.obolibrary.org/obo/DOID_3116 kidney benign neoplasm http://purl.obolibrary.org/obo/DOID_7334 nephrogenic adenoma http://purl.obolibrary.org/obo/DOID_3116 kidney benign neoplasm http://purl.obolibrary.org/obo/DOID_8411 kidney angiomyolipoma http://purl.obolibrary.org/obo/DOID_3116 kidney benign neoplasm http://purl.obolibrary.org/obo/DOID_9253 gastrointestinal stromal tumor http://purl.obolibrary.org/obo/DOID_3119 gastrointestinal system cancer http://purl.obolibrary.org/obo/DOID_12639 pyloric stenosis http://purl.obolibrary.org/obo/DOID_3122 gastric outlet obstruction http://purl.obolibrary.org/obo/DOID_4551 anus benign neoplasm http://purl.obolibrary.org/obo/DOID_4610 intestinal benign neoplasm http://purl.obolibrary.org/obo/DOID_3890 acute intermittent porphyria http://purl.obolibrary.org/obo/DOID_3133 acute porphyria http://purl.obolibrary.org/obo/DOID_4346 variegate porphyria http://purl.obolibrary.org/obo/DOID_3133 acute porphyria http://purl.obolibrary.org/obo/DOID_5230 hepatoerythropoietic porphyria http://purl.obolibrary.org/obo/DOID_3133 acute porphyria http://purl.obolibrary.org/obo/DOID_13269 hereditary coproporphyria http://purl.obolibrary.org/obo/DOID_3133 acute porphyria http://purl.obolibrary.org/obo/DOID_10582 Refsum disease http://purl.obolibrary.org/obo/DOID_3146 lipid metabolism disorder http://purl.obolibrary.org/obo/DOID_1168 familial hyperlipidemia http://purl.obolibrary.org/obo/DOID_3146 lipid metabolism disorder http://purl.obolibrary.org/obo/DOID_1387 hypolipoproteinemia http://purl.obolibrary.org/obo/DOID_3146 lipid metabolism disorder http://purl.obolibrary.org/obo/DOID_14498 lipoid proteinosis http://purl.obolibrary.org/obo/DOID_3146 lipid metabolism disorder http://purl.obolibrary.org/obo/DOID_14692 Smith-Lemli-Opitz syndrome http://purl.obolibrary.org/obo/DOID_3146 lipid metabolism disorder http://purl.obolibrary.org/obo/DOID_3923 diffuse lipomatosis http://purl.obolibrary.org/obo/DOID_3153 lipomatosis http://purl.obolibrary.org/obo/DOID_3927 pelvic lipomatosis http://purl.obolibrary.org/obo/DOID_3153 lipomatosis http://purl.obolibrary.org/obo/DOID_2411 granular cell tumor http://purl.obolibrary.org/obo/DOID_3165 skin benign neoplasm http://purl.obolibrary.org/obo/DOID_2425 cutaneous ganglioneuroma http://purl.obolibrary.org/obo/DOID_3165 skin benign neoplasm http://purl.obolibrary.org/obo/DOID_2433 epidermal appendage tumor http://purl.obolibrary.org/obo/DOID_3165 skin benign neoplasm http://purl.obolibrary.org/obo/DOID_2438 dermis tumor http://purl.obolibrary.org/obo/DOID_3165 skin benign neoplasm http://purl.obolibrary.org/obo/DOID_2495 senile angioma http://purl.obolibrary.org/obo/DOID_3165 skin benign neoplasm http://purl.obolibrary.org/obo/DOID_5375 hair follicle neoplasm http://purl.obolibrary.org/obo/DOID_3165 skin benign neoplasm http://purl.obolibrary.org/obo/DOID_5759 sebaceous gland neoplasm http://purl.obolibrary.org/obo/DOID_3165 skin benign neoplasm http://purl.obolibrary.org/obo/DOID_172 clear cell acanthoma http://purl.obolibrary.org/obo/DOID_3165 skin benign neoplasm http://purl.obolibrary.org/obo/DOID_174 acanthoma http://purl.obolibrary.org/obo/DOID_3168 squamous cell neoplasm http://purl.obolibrary.org/obo/DOID_327 syringomyelia http://purl.obolibrary.org/obo/DOID_319 spinal cord disease http://purl.obolibrary.org/obo/DOID_1089 tethered spinal cord syndrome http://purl.obolibrary.org/obo/DOID_319 spinal cord disease http://purl.obolibrary.org/obo/DOID_3205 melanotic neurilemmoma http://purl.obolibrary.org/obo/DOID_3192 neurilemmoma http://purl.obolibrary.org/obo/DOID_12689 acoustic neuroma http://purl.obolibrary.org/obo/DOID_3192 neurilemmoma http://purl.obolibrary.org/obo/DOID_14500 fucosidosis http://purl.obolibrary.org/obo/DOID_3211 lysosomal storage disease http://purl.obolibrary.org/obo/DOID_1811 reflex sympathetic dystrophy http://purl.obolibrary.org/obo/DOID_3223 complex regional pain syndrome http://purl.obolibrary.org/obo/DOID_3227 tracheal stenosis http://purl.obolibrary.org/obo/DOID_3225 tracheal disease http://purl.obolibrary.org/obo/DOID_3230 high pressure neurological syndrome http://purl.obolibrary.org/obo/DOID_331 central nervous system disease http://purl.obolibrary.org/obo/DOID_607 paraplegia http://purl.obolibrary.org/obo/DOID_331 central nervous system disease http://purl.obolibrary.org/obo/DOID_640 encephalomyelitis http://purl.obolibrary.org/obo/DOID_331 central nervous system disease http://purl.obolibrary.org/obo/DOID_12835 quadriplegia http://purl.obolibrary.org/obo/DOID_331 central nervous system disease http://purl.obolibrary.org/obo/DOID_319 spinal cord disease http://purl.obolibrary.org/obo/DOID_331 central nervous system disease http://purl.obolibrary.org/obo/DOID_3116 kidney benign neoplasm http://purl.obolibrary.org/obo/DOID_731 urinary system benign neoplasm http://purl.obolibrary.org/obo/DOID_1596 mental depression http://purl.obolibrary.org/obo/DOID_3324 mood disorder http://purl.obolibrary.org/obo/DOID_3325 hyperglobulinemic purpura http://purl.obolibrary.org/obo/DOID_3326 purpura http://purl.obolibrary.org/obo/DOID_2647 parachordoma http://purl.obolibrary.org/obo/DOID_3350 mesenchymal cell neoplasm http://purl.obolibrary.org/obo/DOID_2685 ossifying fibromyxoid tumor http://purl.obolibrary.org/obo/DOID_3350 mesenchymal cell neoplasm http://purl.obolibrary.org/obo/DOID_4545 mesenchymal chondrosarcoma http://purl.obolibrary.org/obo/DOID_3371 chondrosarcoma http://purl.obolibrary.org/obo/DOID_2815 cranial nerve malignant neoplasm http://purl.obolibrary.org/obo/DOID_338 cranial nerve neoplasm http://purl.obolibrary.org/obo/DOID_824 periodontitis http://purl.obolibrary.org/obo/DOID_3388 periodontal disease http://purl.obolibrary.org/obo/DOID_4248 coronary stenosis http://purl.obolibrary.org/obo/DOID_3393 coronary artery disease http://purl.obolibrary.org/obo/DOID_8805 intermediate coronary syndrome http://purl.obolibrary.org/obo/DOID_3393 coronary artery disease http://purl.obolibrary.org/obo/DOID_11840 coronary artery vasospasm http://purl.obolibrary.org/obo/DOID_3393 coronary artery disease http://purl.obolibrary.org/obo/DOID_807 carotid artery occlusion http://purl.obolibrary.org/obo/DOID_5976 occlusion precerebral artery http://purl.obolibrary.org/obo/DOID_9348 carotid artery dissection http://purl.obolibrary.org/obo/DOID_3407 carotid artery disease http://purl.obolibrary.org/obo/DOID_13001 carotid stenosis http://purl.obolibrary.org/obo/DOID_3407 carotid artery disease http://purl.obolibrary.org/obo/DOID_10300 Raynaud disease http://purl.obolibrary.org/obo/DOID_341 peripheral vascular disease http://purl.obolibrary.org/obo/DOID_1272 telangiectasis http://purl.obolibrary.org/obo/DOID_341 peripheral vascular disease http://purl.obolibrary.org/obo/DOID_13866 multiple cranial nerve palsy http://purl.obolibrary.org/obo/DOID_3418 glossopharyngeal nerve disease http://purl.obolibrary.org/obo/DOID_14423 glossopharyngeal neuralgia http://purl.obolibrary.org/obo/DOID_3418 glossopharyngeal nerve disease http://purl.obolibrary.org/obo/DOID_9847 peripheral vertigo http://purl.obolibrary.org/obo/DOID_3426 vestibular disease http://purl.obolibrary.org/obo/DOID_9346 Taylor's syndrome http://purl.obolibrary.org/obo/DOID_345 uterine disease http://purl.obolibrary.org/obo/DOID_3965 Merkel cell carcinoma http://purl.obolibrary.org/obo/DOID_3451 skin carcinoma http://purl.obolibrary.org/obo/DOID_4683 cutaneous mucoepidermoid carcinoma http://purl.obolibrary.org/obo/DOID_3451 skin carcinoma http://purl.obolibrary.org/obo/DOID_5376 skin pilomatrix carcinoma http://purl.obolibrary.org/obo/DOID_3451 skin carcinoma http://purl.obolibrary.org/obo/DOID_6425 eyelid carcinoma http://purl.obolibrary.org/obo/DOID_530 eyelid disease http://purl.obolibrary.org/obo/DOID_5050 Ehrlich tumor carcinoma http://purl.obolibrary.org/obo/DOID_3459 breast carcinoma http://purl.obolibrary.org/obo/DOID_1417 choroid disease http://purl.obolibrary.org/obo/DOID_3480 uveal disease http://purl.obolibrary.org/obo/DOID_240 iris disease http://purl.obolibrary.org/obo/DOID_3480 uveal disease http://purl.obolibrary.org/obo/DOID_10941 intracranial aneurysm http://purl.obolibrary.org/obo/DOID_3527 cerebral arterial disease http://purl.obolibrary.org/obo/DOID_14174 central neurocytoma http://purl.obolibrary.org/obo/DOID_3541 cerebral ventricle cancer http://purl.obolibrary.org/obo/DOID_3557 superior mesenteric artery syndrome http://purl.obolibrary.org/obo/DOID_3558 duodenal obstruction http://purl.obolibrary.org/obo/DOID_4591 lymphoplasmacyte-rich meningioma http://purl.obolibrary.org/obo/DOID_3565 meningioma http://purl.obolibrary.org/obo/DOID_6110 jugular foramen meningioma http://purl.obolibrary.org/obo/DOID_3565 meningioma http://purl.obolibrary.org/obo/DOID_7210 psammomatous meningioma http://purl.obolibrary.org/obo/DOID_3565 meningioma http://purl.obolibrary.org/obo/DOID_7211 fibrous meningioma http://purl.obolibrary.org/obo/DOID_3565 meningioma http://purl.obolibrary.org/obo/DOID_7634 suprasellar meningioma http://purl.obolibrary.org/obo/DOID_3565 meningioma http://purl.obolibrary.org/obo/DOID_8031 pineal region meningioma http://purl.obolibrary.org/obo/DOID_5032 pineal gland cancer http://purl.obolibrary.org/obo/DOID_1130 pituitary infarct http://purl.obolibrary.org/obo/DOID_3646 necrosis of pituitary http://purl.obolibrary.org/obo/DOID_724 female stress incontinence http://purl.obolibrary.org/obo/DOID_365 bladder disease http://purl.obolibrary.org/obo/DOID_11353 bladder diverticulum http://purl.obolibrary.org/obo/DOID_365 bladder disease http://purl.obolibrary.org/obo/DOID_12143 neurogenic bladder http://purl.obolibrary.org/obo/DOID_365 bladder disease http://purl.obolibrary.org/obo/DOID_12144 low compliance bladder http://purl.obolibrary.org/obo/DOID_365 bladder disease http://purl.obolibrary.org/obo/DOID_12145 detrusor sphincter dyssynergia http://purl.obolibrary.org/obo/DOID_365 bladder disease http://purl.obolibrary.org/obo/DOID_13948 bladder neck obstruction http://purl.obolibrary.org/obo/DOID_365 bladder disease http://purl.obolibrary.org/obo/DOID_2732 Rothmund-Thomson syndrome http://purl.obolibrary.org/obo/DOID_37 skin disease http://purl.obolibrary.org/obo/DOID_2733 skin atrophy http://purl.obolibrary.org/obo/DOID_37 skin disease http://purl.obolibrary.org/obo/DOID_3134 facial dermatosis http://purl.obolibrary.org/obo/DOID_37 skin disease http://purl.obolibrary.org/obo/DOID_3136 scalp dermatosis http://purl.obolibrary.org/obo/DOID_37 skin disease http://purl.obolibrary.org/obo/DOID_3158 hand dermatosis http://purl.obolibrary.org/obo/DOID_37 skin disease http://purl.obolibrary.org/obo/DOID_4603 epidermolytic hyperkeratosis http://purl.obolibrary.org/obo/DOID_37 skin disease http://purl.obolibrary.org/obo/DOID_4702 mongolian spot http://purl.obolibrary.org/obo/DOID_37 skin disease http://purl.obolibrary.org/obo/DOID_7365 Kimura disease http://purl.obolibrary.org/obo/DOID_37 skin disease http://purl.obolibrary.org/obo/DOID_8549 chronic ulcer of skin http://purl.obolibrary.org/obo/DOID_37 skin disease http://purl.obolibrary.org/obo/DOID_8574 lichen disease http://purl.obolibrary.org/obo/DOID_37 skin disease http://purl.obolibrary.org/obo/DOID_8881 rosacea http://purl.obolibrary.org/obo/DOID_37 skin disease http://purl.obolibrary.org/obo/DOID_3153 lipomatosis http://purl.obolibrary.org/obo/DOID_37 skin disease http://purl.obolibrary.org/obo/DOID_528 hydrarthrosis http://purl.obolibrary.org/obo/DOID_381 arthropathy http://purl.obolibrary.org/obo/DOID_801 hemarthrosis http://purl.obolibrary.org/obo/DOID_381 arthropathy http://purl.obolibrary.org/obo/DOID_10393 secondary hypertrophic osteoarthropathy http://purl.obolibrary.org/obo/DOID_381 arthropathy http://purl.obolibrary.org/obo/DOID_13781 hypermobility syndrome http://purl.obolibrary.org/obo/DOID_381 arthropathy http://purl.obolibrary.org/obo/DOID_14284 patellofemoral pain syndrome http://purl.obolibrary.org/obo/DOID_381 arthropathy http://purl.obolibrary.org/obo/DOID_2092 transient arthritis http://purl.obolibrary.org/obo/DOID_381 arthropathy http://purl.obolibrary.org/obo/DOID_2965 bursitis http://purl.obolibrary.org/obo/DOID_381 arthropathy http://purl.obolibrary.org/obo/DOID_970 tenosynovitis http://purl.obolibrary.org/obo/DOID_971 tendinitis http://purl.obolibrary.org/obo/DOID_8003 alveoli adenoma http://purl.obolibrary.org/obo/DOID_657 adenoma http://purl.obolibrary.org/obo/DOID_10778 fiedler's myocarditis http://purl.obolibrary.org/obo/DOID_3951 acute myocarditis http://purl.obolibrary.org/obo/DOID_4968 Nelson syndrome http://purl.obolibrary.org/obo/DOID_3952 adrenal cortex disease http://purl.obolibrary.org/obo/DOID_10493 adrenal cortical hypofunction http://purl.obolibrary.org/obo/DOID_3952 adrenal cortex disease http://purl.obolibrary.org/obo/DOID_12932 endomyocardial fibrosis http://purl.obolibrary.org/obo/DOID_397 restrictive cardiomyopathy http://purl.obolibrary.org/obo/DOID_4043 skeletal muscle cancer http://purl.obolibrary.org/obo/DOID_4045 muscle cancer http://purl.obolibrary.org/obo/DOID_4230 smooth muscle cancer http://purl.obolibrary.org/obo/DOID_4045 muscle cancer http://purl.obolibrary.org/obo/DOID_5749 pulmonary valve disease http://purl.obolibrary.org/obo/DOID_4079 heart valve disease http://purl.obolibrary.org/obo/DOID_61 mitral valve disease http://purl.obolibrary.org/obo/DOID_4079 heart valve disease http://purl.obolibrary.org/obo/DOID_62 aortic valve disease http://purl.obolibrary.org/obo/DOID_520 aortic disease http://purl.obolibrary.org/obo/DOID_893 Wilson disease http://purl.obolibrary.org/obo/DOID_896 metal metabolism disorder http://purl.obolibrary.org/obo/DOID_900 hepatopulmonary syndrome http://purl.obolibrary.org/obo/DOID_409 liver disease http://purl.obolibrary.org/obo/DOID_918 liver inflammatory pseudotumor http://purl.obolibrary.org/obo/DOID_409 liver disease http://purl.obolibrary.org/obo/DOID_2237 hepatitis http://purl.obolibrary.org/obo/DOID_409 liver disease http://purl.obolibrary.org/obo/DOID_5082 liver cirrhosis http://purl.obolibrary.org/obo/DOID_409 liver disease http://purl.obolibrary.org/obo/DOID_11755 choledocholithiasis http://purl.obolibrary.org/obo/DOID_4137 common bile duct disease http://purl.obolibrary.org/obo/DOID_4137 common bile duct disease http://purl.obolibrary.org/obo/DOID_4138 bile duct disease http://purl.obolibrary.org/obo/DOID_5042 malignant granular cell myoblastoma http://purl.obolibrary.org/obo/DOID_4159 skin cancer http://purl.obolibrary.org/obo/DOID_4183 pseudopseudohypoparathyroidism http://purl.obolibrary.org/obo/DOID_4184 pseudohypoparathyroidism http://purl.obolibrary.org/obo/DOID_4195 hyperglycemia http://purl.obolibrary.org/obo/DOID_4194 glucose metabolism disease http://purl.obolibrary.org/obo/DOID_10603 glucose intolerance http://purl.obolibrary.org/obo/DOID_4195 hyperglycemia http://purl.obolibrary.org/obo/DOID_6458 cerebellar liponeurocytoma http://purl.obolibrary.org/obo/DOID_4205 cerebellum cancer http://purl.obolibrary.org/obo/DOID_8553 pyoderma gangrenosum http://purl.obolibrary.org/obo/DOID_4223 pyoderma http://purl.obolibrary.org/obo/DOID_431 myofascial pain syndrome http://purl.obolibrary.org/obo/DOID_423 myopathy http://purl.obolibrary.org/obo/DOID_767 muscular atrophy http://purl.obolibrary.org/obo/DOID_423 myopathy http://purl.obolibrary.org/obo/DOID_4250 conjunctivochalasis http://purl.obolibrary.org/obo/DOID_4251 conjunctival disease http://purl.obolibrary.org/obo/DOID_10139 conjunctival degeneration http://purl.obolibrary.org/obo/DOID_9799 eye degenerative disease http://purl.obolibrary.org/obo/DOID_4424 juvenile xanthogranuloma http://purl.obolibrary.org/obo/DOID_4330 non-Langerhans-cell histiocytosis http://purl.obolibrary.org/obo/DOID_2007 degeneration of macula and posterior pole http://purl.obolibrary.org/obo/DOID_4448 macular degeneration http://purl.obolibrary.org/obo/DOID_9432 renal glycosuria http://purl.obolibrary.org/obo/DOID_447 renal tubular transport disease http://purl.obolibrary.org/obo/DOID_4479 pseudohypoaldosteronism http://purl.obolibrary.org/obo/DOID_447 renal tubular transport disease http://purl.obolibrary.org/obo/DOID_6658 pulmonary large cell neuroendocrine carcinoma http://purl.obolibrary.org/obo/DOID_4556 lung large cell carcinoma http://purl.obolibrary.org/obo/DOID_11240 appendiceal neoplasm http://purl.obolibrary.org/obo/DOID_4610 intestinal benign neoplasm http://purl.obolibrary.org/obo/DOID_1984 rectal benign neoplasm http://purl.obolibrary.org/obo/DOID_4610 intestinal benign neoplasm http://purl.obolibrary.org/obo/DOID_13626 photokeratitis http://purl.obolibrary.org/obo/DOID_4677 keratitis http://purl.obolibrary.org/obo/DOID_8463 corneal ulcer http://purl.obolibrary.org/obo/DOID_4677 keratitis http://purl.obolibrary.org/obo/DOID_9858 deep keratitis http://purl.obolibrary.org/obo/DOID_4677 keratitis http://purl.obolibrary.org/obo/DOID_11132 prostatic hypertrophy http://purl.obolibrary.org/obo/DOID_47 prostate disease http://purl.obolibrary.org/obo/DOID_14654 prostatitis http://purl.obolibrary.org/obo/DOID_47 prostate disease http://purl.obolibrary.org/obo/DOID_4203 brain stem cancer http://purl.obolibrary.org/obo/DOID_4706 infratentorial cancer http://purl.obolibrary.org/obo/DOID_479 angiokeratoma http://purl.obolibrary.org/obo/DOID_471 skin hemangioma http://purl.obolibrary.org/obo/DOID_14066 acute diffuse nephritis http://purl.obolibrary.org/obo/DOID_4781 diffuse glomerulonephritis http://purl.obolibrary.org/obo/DOID_9912 hydrocele http://purl.obolibrary.org/obo/DOID_48 male reproductive system disease http://purl.obolibrary.org/obo/DOID_11997 spermatocele http://purl.obolibrary.org/obo/DOID_48 male reproductive system disease http://purl.obolibrary.org/obo/DOID_12336 male infertility http://purl.obolibrary.org/obo/DOID_48 male reproductive system disease http://purl.obolibrary.org/obo/DOID_1529 penile disease http://purl.obolibrary.org/obo/DOID_48 male reproductive system disease http://purl.obolibrary.org/obo/DOID_47 prostate disease http://purl.obolibrary.org/obo/DOID_48 male reproductive system disease http://purl.obolibrary.org/obo/DOID_9365 vesiculitis http://purl.obolibrary.org/obo/DOID_48 male reproductive system disease http://purl.obolibrary.org/obo/DOID_543 dystonia http://purl.obolibrary.org/obo/DOID_480 movement disease http://purl.obolibrary.org/obo/DOID_4976 elephantiasis http://purl.obolibrary.org/obo/DOID_4977 lymphedema http://purl.obolibrary.org/obo/DOID_2856 euthyroid sick syndrome http://purl.obolibrary.org/obo/DOID_50 thyroid gland disease http://purl.obolibrary.org/obo/DOID_12837 thyroid crisis http://purl.obolibrary.org/obo/DOID_50 thyroid gland disease http://purl.obolibrary.org/obo/DOID_7166 thyroiditis http://purl.obolibrary.org/obo/DOID_50 thyroid gland disease http://purl.obolibrary.org/obo/DOID_14018 alcoholic liver cirrhosis http://purl.obolibrary.org/obo/DOID_5082 liver cirrhosis http://purl.obolibrary.org/obo/DOID_5782 tympanic membrane disease http://purl.obolibrary.org/obo/DOID_5100 middle ear disease http://purl.obolibrary.org/obo/DOID_519 aortitis http://purl.obolibrary.org/obo/DOID_520 aortic disease http://purl.obolibrary.org/obo/DOID_11111 hydronephrosis http://purl.obolibrary.org/obo/DOID_5200 urinary tract obstruction http://purl.obolibrary.org/obo/DOID_14175 von Hippel-Lindau disease http://purl.obolibrary.org/obo/DOID_5241 hemangioblastoma http://purl.obolibrary.org/obo/DOID_2074 intestinal perforation http://purl.obolibrary.org/obo/DOID_5295 intestinal disease http://purl.obolibrary.org/obo/DOID_3852 Peutz-Jeghers syndrome http://purl.obolibrary.org/obo/DOID_5295 intestinal disease http://purl.obolibrary.org/obo/DOID_4072 duodenum disease http://purl.obolibrary.org/obo/DOID_5295 intestinal disease http://purl.obolibrary.org/obo/DOID_8437 intestinal obstruction http://purl.obolibrary.org/obo/DOID_5295 intestinal disease http://purl.obolibrary.org/obo/DOID_8476 Whipple disease http://purl.obolibrary.org/obo/DOID_5295 intestinal disease http://purl.obolibrary.org/obo/DOID_8633 chronic intestinal vascular insufficiency http://purl.obolibrary.org/obo/DOID_5295 intestinal disease http://purl.obolibrary.org/obo/DOID_8643 duodenitis http://purl.obolibrary.org/obo/DOID_5295 intestinal disease http://purl.obolibrary.org/obo/DOID_9779 bowel dysfunction http://purl.obolibrary.org/obo/DOID_5295 intestinal disease http://purl.obolibrary.org/obo/DOID_10486 intestinal atresia http://purl.obolibrary.org/obo/DOID_5295 intestinal disease http://purl.obolibrary.org/obo/DOID_10607 tropical sprue http://purl.obolibrary.org/obo/DOID_5295 intestinal disease http://purl.obolibrary.org/obo/DOID_10611 protein-losing enteropathy http://purl.obolibrary.org/obo/DOID_5295 intestinal disease http://purl.obolibrary.org/obo/DOID_1285 rectal disease http://purl.obolibrary.org/obo/DOID_5295 intestinal disease http://purl.obolibrary.org/obo/DOID_2444 hyperpituitarism http://purl.obolibrary.org/obo/DOID_53 pituitary gland disease http://purl.obolibrary.org/obo/DOID_3401 inappropriate ADH syndrome http://purl.obolibrary.org/obo/DOID_53 pituitary gland disease http://purl.obolibrary.org/obo/DOID_3642 empty sella syndrome http://purl.obolibrary.org/obo/DOID_53 pituitary gland disease http://purl.obolibrary.org/obo/DOID_7378 pituitary hypoplasia http://purl.obolibrary.org/obo/DOID_53 pituitary gland disease http://purl.obolibrary.org/obo/DOID_3646 necrosis of pituitary http://purl.obolibrary.org/obo/DOID_53 pituitary gland disease http://purl.obolibrary.org/obo/DOID_10348 blepharophimosis http://purl.obolibrary.org/obo/DOID_530 eyelid disease http://purl.obolibrary.org/obo/DOID_12397 entropion http://purl.obolibrary.org/obo/DOID_530 eyelid disease http://purl.obolibrary.org/obo/DOID_12959 lagophthalmos http://purl.obolibrary.org/obo/DOID_530 eyelid disease http://purl.obolibrary.org/obo/DOID_1570 ectropion http://purl.obolibrary.org/obo/DOID_530 eyelid disease http://purl.obolibrary.org/obo/DOID_12514 retinal perforation http://purl.obolibrary.org/obo/DOID_5327 retinal detachment http://purl.obolibrary.org/obo/DOID_5608 dental pulp calcification http://purl.obolibrary.org/obo/DOID_5330 dental pulp disease http://purl.obolibrary.org/obo/DOID_11121 pulpitis http://purl.obolibrary.org/obo/DOID_5330 dental pulp disease http://purl.obolibrary.org/obo/DOID_11623 dental pulp necrosis http://purl.obolibrary.org/obo/DOID_5330 dental pulp disease http://purl.obolibrary.org/obo/DOID_3877 functional colonic disease http://purl.obolibrary.org/obo/DOID_5353 colonic disease http://purl.obolibrary.org/obo/DOID_10655 lipoma of colon http://purl.obolibrary.org/obo/DOID_6460 large intestine lipoma http://purl.obolibrary.org/obo/DOID_9837 hypertropia http://purl.obolibrary.org/obo/DOID_540 strabismus http://purl.obolibrary.org/obo/DOID_9841 hypotropia http://purl.obolibrary.org/obo/DOID_540 strabismus http://purl.obolibrary.org/obo/DOID_10863 paralytic squint http://purl.obolibrary.org/obo/DOID_540 strabismus http://purl.obolibrary.org/obo/DOID_1143 exotropia http://purl.obolibrary.org/obo/DOID_540 strabismus http://purl.obolibrary.org/obo/DOID_12445 conjugate gaze palsy http://purl.obolibrary.org/obo/DOID_540 strabismus http://purl.obolibrary.org/obo/DOID_12557 Duane retraction syndrome http://purl.obolibrary.org/obo/DOID_540 strabismus http://purl.obolibrary.org/obo/DOID_12667 binocular vision disease http://purl.obolibrary.org/obo/DOID_540 strabismus http://purl.obolibrary.org/obo/DOID_2975 cystic kidney disease http://purl.obolibrary.org/obo/DOID_557 kidney disease http://purl.obolibrary.org/obo/DOID_2982 perinephritis http://purl.obolibrary.org/obo/DOID_557 kidney disease http://purl.obolibrary.org/obo/DOID_2983 anuria http://purl.obolibrary.org/obo/DOID_557 kidney disease http://purl.obolibrary.org/obo/DOID_9622 kidney hypertrophy http://purl.obolibrary.org/obo/DOID_557 kidney disease http://purl.obolibrary.org/obo/DOID_12679 nephrocalcinosis http://purl.obolibrary.org/obo/DOID_557 kidney disease http://purl.obolibrary.org/obo/DOID_13068 renal osteodystrophy http://purl.obolibrary.org/obo/DOID_557 kidney disease http://purl.obolibrary.org/obo/DOID_2744 pyelitis http://purl.obolibrary.org/obo/DOID_557 kidney disease http://purl.obolibrary.org/obo/DOID_447 renal tubular transport disease http://purl.obolibrary.org/obo/DOID_557 kidney disease http://purl.obolibrary.org/obo/DOID_9409 diabetes insipidus http://purl.obolibrary.org/obo/DOID_557 kidney disease http://purl.obolibrary.org/obo/DOID_12098 trigeminal neuralgia http://purl.obolibrary.org/obo/DOID_561 trigeminal nerve disease http://purl.obolibrary.org/obo/DOID_1140 spinal canal and spinal cord meningioma http://purl.obolibrary.org/obo/DOID_5612 spinal cancer http://purl.obolibrary.org/obo/DOID_9335 scotoma http://purl.obolibrary.org/obo/DOID_5614 eye disease http://purl.obolibrary.org/obo/DOID_1279 ocular motility disease http://purl.obolibrary.org/obo/DOID_5656 cranial nerve disease http://purl.obolibrary.org/obo/DOID_790 ocular hypotension http://purl.obolibrary.org/obo/DOID_5614 eye disease http://purl.obolibrary.org/obo/DOID_8501 fundus dystrophy http://purl.obolibrary.org/obo/DOID_5614 eye disease http://purl.obolibrary.org/obo/DOID_8886 chorioretinitis http://purl.obolibrary.org/obo/DOID_5614 eye disease http://purl.obolibrary.org/obo/DOID_9368 keratoconjunctivitis http://purl.obolibrary.org/obo/DOID_5614 eye disease http://purl.obolibrary.org/obo/DOID_9799 eye degenerative disease http://purl.obolibrary.org/obo/DOID_5614 eye disease http://purl.obolibrary.org/obo/DOID_9835 refractive error http://purl.obolibrary.org/obo/DOID_5614 eye disease http://purl.obolibrary.org/obo/DOID_1756 facial nerve disease http://purl.obolibrary.org/obo/DOID_5656 cranial nerve disease http://purl.obolibrary.org/obo/DOID_561 trigeminal nerve disease http://purl.obolibrary.org/obo/DOID_5656 cranial nerve disease http://purl.obolibrary.org/obo/DOID_6929 retinal edema http://purl.obolibrary.org/obo/DOID_5679 retinal disease http://purl.obolibrary.org/obo/DOID_7633 macular holes http://purl.obolibrary.org/obo/DOID_5679 retinal disease http://purl.obolibrary.org/obo/DOID_11086 chorioretinal scar http://purl.obolibrary.org/obo/DOID_5679 retinal disease http://purl.obolibrary.org/obo/DOID_11561 hypertensive retinopathy http://purl.obolibrary.org/obo/DOID_5679 retinal disease http://purl.obolibrary.org/obo/DOID_13025 retinopathy of prematurity http://purl.obolibrary.org/obo/DOID_5679 retinal disease http://purl.obolibrary.org/obo/DOID_13401 angioid streaks http://purl.obolibrary.org/obo/DOID_5679 retinal disease http://purl.obolibrary.org/obo/DOID_3612 retinitis http://purl.obolibrary.org/obo/DOID_5679 retinal disease http://purl.obolibrary.org/obo/DOID_5327 retinal detachment http://purl.obolibrary.org/obo/DOID_5679 retinal disease http://purl.obolibrary.org/obo/DOID_11831 cortical blindness http://purl.obolibrary.org/obo/DOID_5691 visual cortex disease http://purl.obolibrary.org/obo/DOID_571 median neuropathy http://purl.obolibrary.org/obo/DOID_572 mononeuritis of upper limb and mononeuritis multiplex http://purl.obolibrary.org/obo/DOID_12168 ulnar nerve lesion http://purl.obolibrary.org/obo/DOID_572 mononeuritis of upper limb and mononeuritis multiplex http://purl.obolibrary.org/obo/DOID_12169 carpal tunnel syndrome http://purl.obolibrary.org/obo/DOID_573 nerve compression syndrome http://purl.obolibrary.org/obo/DOID_5732 pyosalpinx http://purl.obolibrary.org/obo/DOID_5733 salpingitis http://purl.obolibrary.org/obo/DOID_10973 acute salpingitis http://purl.obolibrary.org/obo/DOID_5733 salpingitis http://purl.obolibrary.org/obo/DOID_6925 peroneal nerve paralysis http://purl.obolibrary.org/obo/DOID_574 peripheral nervous system disease http://purl.obolibrary.org/obo/DOID_11465 autonomic nervous system disease http://purl.obolibrary.org/obo/DOID_574 peripheral nervous system disease http://purl.obolibrary.org/obo/DOID_573 nerve compression syndrome http://purl.obolibrary.org/obo/DOID_574 peripheral nervous system disease http://purl.obolibrary.org/obo/DOID_6420 pulmonary valve stenosis http://purl.obolibrary.org/obo/DOID_5749 pulmonary valve disease http://purl.obolibrary.org/obo/DOID_13790 acute tympanitis http://purl.obolibrary.org/obo/DOID_5782 tympanic membrane disease http://purl.obolibrary.org/obo/DOID_2860 hemoglobinopathy http://purl.obolibrary.org/obo/DOID_589 congenital hemolytic anemia http://purl.obolibrary.org/obo/DOID_6707 malignant triton tumor http://purl.obolibrary.org/obo/DOID_5940 malignant peripheral nerve sheath tumor http://purl.obolibrary.org/obo/DOID_9651 systolic heart failure http://purl.obolibrary.org/obo/DOID_6000 congestive heart failure http://purl.obolibrary.org/obo/DOID_9775 diastolic heart failure http://purl.obolibrary.org/obo/DOID_6000 congestive heart failure http://purl.obolibrary.org/obo/DOID_9192 dyskinesia of esophagus http://purl.obolibrary.org/obo/DOID_6050 esophageal disease http://purl.obolibrary.org/obo/DOID_9206 Barrett's esophagus http://purl.obolibrary.org/obo/DOID_6050 esophageal disease http://purl.obolibrary.org/obo/DOID_10485 esophageal atresia http://purl.obolibrary.org/obo/DOID_6050 esophageal disease http://purl.obolibrary.org/obo/DOID_112 esophageal varix http://purl.obolibrary.org/obo/DOID_866 vein disease http://purl.obolibrary.org/obo/DOID_11963 esophagitis http://purl.obolibrary.org/obo/DOID_6050 esophageal disease http://purl.obolibrary.org/obo/DOID_11502 mitral valve insufficiency http://purl.obolibrary.org/obo/DOID_61 mitral valve disease http://purl.obolibrary.org/obo/DOID_11184 acute conjunctivitis http://purl.obolibrary.org/obo/DOID_6195 conjunctivitis http://purl.obolibrary.org/obo/DOID_2475 chronic conjunctivitis http://purl.obolibrary.org/obo/DOID_6195 conjunctivitis http://purl.obolibrary.org/obo/DOID_12451 sulfhemoglobinemia http://purl.obolibrary.org/obo/DOID_620 blood protein disease http://purl.obolibrary.org/obo/DOID_631 fibromyalgia http://purl.obolibrary.org/obo/DOID_633 myositis http://purl.obolibrary.org/obo/DOID_971 tendinitis http://purl.obolibrary.org/obo/DOID_633 myositis http://purl.obolibrary.org/obo/DOID_5453 pulmonary venoocclusive disease http://purl.obolibrary.org/obo/DOID_6432 pulmonary hypertension http://purl.obolibrary.org/obo/DOID_13042 persistent fetal circulation syndrome http://purl.obolibrary.org/obo/DOID_6432 pulmonary hypertension http://purl.obolibrary.org/obo/DOID_3530 chronic wasting disease http://purl.obolibrary.org/obo/DOID_649 prion disease http://purl.obolibrary.org/obo/DOID_5434 scrapie http://purl.obolibrary.org/obo/DOID_649 prion disease http://purl.obolibrary.org/obo/DOID_5435 variant Creutzfeldt-Jakob disease http://purl.obolibrary.org/obo/DOID_649 prion disease http://purl.obolibrary.org/obo/DOID_648 kuru http://purl.obolibrary.org/obo/DOID_649 prion disease http://purl.obolibrary.org/obo/DOID_11949 Creutzfeldt-Jakob disease http://purl.obolibrary.org/obo/DOID_649 prion disease http://purl.obolibrary.org/obo/DOID_11684 melanoacanthoma http://purl.obolibrary.org/obo/DOID_6498 seborrheic keratosis http://purl.obolibrary.org/obo/DOID_3172 papillary adenoma http://purl.obolibrary.org/obo/DOID_657 adenoma http://purl.obolibrary.org/obo/DOID_4193 intracranial thrombosis http://purl.obolibrary.org/obo/DOID_0060903 thrombosis http://purl.obolibrary.org/obo/DOID_4372 intracranial embolism http://purl.obolibrary.org/obo/DOID_6713 cerebrovascular disease http://purl.obolibrary.org/obo/DOID_11390 cerebral arteritis http://purl.obolibrary.org/obo/DOID_6713 cerebrovascular disease http://purl.obolibrary.org/obo/DOID_13089 intracranial arterial disease http://purl.obolibrary.org/obo/DOID_6713 cerebrovascular disease http://purl.obolibrary.org/obo/DOID_13100 intracranial vasospasm http://purl.obolibrary.org/obo/DOID_6713 cerebrovascular disease http://purl.obolibrary.org/obo/DOID_5976 occlusion precerebral artery http://purl.obolibrary.org/obo/DOID_6713 cerebrovascular disease http://purl.obolibrary.org/obo/DOID_890 mitochondrial encephalomyopathy http://purl.obolibrary.org/obo/DOID_699 mitochondrial myopathy http://purl.obolibrary.org/obo/DOID_12558 chronic progressive external ophthalmoplegia http://purl.obolibrary.org/obo/DOID_699 mitochondrial myopathy http://purl.obolibrary.org/obo/DOID_706 mature B-cell neoplasm http://purl.obolibrary.org/obo/DOID_707 B-cell lymphoma http://purl.obolibrary.org/obo/DOID_7165 subacute thyroiditis http://purl.obolibrary.org/obo/DOID_7166 thyroiditis http://purl.obolibrary.org/obo/DOID_7187 subacute lymphocytic thyroiditis http://purl.obolibrary.org/obo/DOID_7166 thyroiditis http://purl.obolibrary.org/obo/DOID_14350 suppurative thyroiditis http://purl.obolibrary.org/obo/DOID_7166 thyroiditis http://purl.obolibrary.org/obo/DOID_12577 urethral obstruction http://purl.obolibrary.org/obo/DOID_732 urethral disease http://purl.obolibrary.org/obo/DOID_1343 urethritis http://purl.obolibrary.org/obo/DOID_732 urethral disease http://purl.obolibrary.org/obo/DOID_13461 urethral intrinsic sphincter deficiency http://purl.obolibrary.org/obo/DOID_732 urethral disease http://purl.obolibrary.org/obo/DOID_13498 urethral syndrome http://purl.obolibrary.org/obo/DOID_732 urethral disease http://purl.obolibrary.org/obo/DOID_4176 blood group incompatibility http://purl.obolibrary.org/obo/DOID_74 hematopoietic system disease http://purl.obolibrary.org/obo/DOID_4961 bone marrow disease http://purl.obolibrary.org/obo/DOID_74 hematopoietic system disease http://purl.obolibrary.org/obo/DOID_620 blood protein disease http://purl.obolibrary.org/obo/DOID_74 hematopoietic system disease http://purl.obolibrary.org/obo/DOID_4347 lymphocele http://purl.obolibrary.org/obo/DOID_75 lymphatic system disease http://purl.obolibrary.org/obo/DOID_533 thymus gland disease http://purl.obolibrary.org/obo/DOID_75 lymphatic system disease http://purl.obolibrary.org/obo/DOID_2529 splenic disease http://purl.obolibrary.org/obo/DOID_75 lymphatic system disease http://purl.obolibrary.org/obo/DOID_4977 lymphedema http://purl.obolibrary.org/obo/DOID_75 lymphatic system disease http://purl.obolibrary.org/obo/DOID_9942 lymph node disease http://purl.obolibrary.org/obo/DOID_75 lymphatic system disease http://purl.obolibrary.org/obo/DOID_752 peptic ulcer perforation http://purl.obolibrary.org/obo/DOID_750 peptic ulcer disease http://purl.obolibrary.org/obo/DOID_8644 gastroduodenitis http://purl.obolibrary.org/obo/DOID_750 peptic ulcer disease http://purl.obolibrary.org/obo/DOID_1724 duodenal ulcer http://purl.obolibrary.org/obo/DOID_750 peptic ulcer disease http://purl.obolibrary.org/obo/DOID_3229 gastric dilatation http://purl.obolibrary.org/obo/DOID_76 stomach disease http://purl.obolibrary.org/obo/DOID_1159 functional gastric disease http://purl.obolibrary.org/obo/DOID_76 stomach disease http://purl.obolibrary.org/obo/DOID_12234 cascade stomach http://purl.obolibrary.org/obo/DOID_76 stomach disease http://purl.obolibrary.org/obo/DOID_12642 hiatus hernia http://purl.obolibrary.org/obo/DOID_76 stomach disease http://purl.obolibrary.org/obo/DOID_3122 gastric outlet obstruction http://purl.obolibrary.org/obo/DOID_76 stomach disease http://purl.obolibrary.org/obo/DOID_4160 differentiating neuroblastoma http://purl.obolibrary.org/obo/DOID_769 neuroblastoma http://purl.obolibrary.org/obo/DOID_4163 ganglioneuroblastoma http://purl.obolibrary.org/obo/DOID_769 neuroblastoma http://purl.obolibrary.org/obo/DOID_8534 gastroesophageal reflux disease http://purl.obolibrary.org/obo/DOID_77 gastrointestinal system disease http://purl.obolibrary.org/obo/DOID_8677 perinatal necrotizing enterocolitis http://purl.obolibrary.org/obo/DOID_77 gastrointestinal system disease http://purl.obolibrary.org/obo/DOID_750 peptic ulcer disease http://purl.obolibrary.org/obo/DOID_77 gastrointestinal system disease http://purl.obolibrary.org/obo/DOID_11527 laryngostenosis http://purl.obolibrary.org/obo/DOID_786 laryngeal disease http://purl.obolibrary.org/obo/DOID_12573 neonatal thyrotoxicosis http://purl.obolibrary.org/obo/DOID_7997 thyrotoxicosis http://purl.obolibrary.org/obo/DOID_10719 toxic diffuse goiter http://purl.obolibrary.org/obo/DOID_7998 hyperthyroidism http://purl.obolibrary.org/obo/DOID_11277 Plummer's disease http://purl.obolibrary.org/obo/DOID_7998 hyperthyroidism http://purl.obolibrary.org/obo/DOID_11269 chronic apical periodontitis http://purl.obolibrary.org/obo/DOID_823 periapical periodontitis http://purl.obolibrary.org/obo/DOID_11693 acute apical periodontitis http://purl.obolibrary.org/obo/DOID_823 periapical periodontitis http://purl.obolibrary.org/obo/DOID_823 periapical periodontitis http://purl.obolibrary.org/obo/DOID_824 periodontitis http://purl.obolibrary.org/obo/DOID_14495 dumping syndrome http://purl.obolibrary.org/obo/DOID_8439 postgastrectomy syndrome http://purl.obolibrary.org/obo/DOID_12161 peripheral retinal degeneration http://purl.obolibrary.org/obo/DOID_8466 retinal degeneration http://purl.obolibrary.org/obo/DOID_8465 retinoschisis http://purl.obolibrary.org/obo/DOID_8466 retinal degeneration http://purl.obolibrary.org/obo/DOID_13094 branch retinal artery occlusion http://purl.obolibrary.org/obo/DOID_8483 retinal artery occlusion http://purl.obolibrary.org/obo/DOID_1727 retinal vein occlusion http://purl.obolibrary.org/obo/DOID_866 vein disease http://purl.obolibrary.org/obo/DOID_8498 hereditary night blindness http://purl.obolibrary.org/obo/DOID_8499 night blindness http://purl.obolibrary.org/obo/DOID_14251 vitreoretinal dystrophy http://purl.obolibrary.org/obo/DOID_8501 fundus dystrophy http://purl.obolibrary.org/obo/DOID_8508 subcorneal pustular dermatosis http://purl.obolibrary.org/obo/DOID_8502 bullous skin disease http://purl.obolibrary.org/obo/DOID_8514 acute pulmonary heart disease http://purl.obolibrary.org/obo/DOID_8515 Cor pulmonale http://purl.obolibrary.org/obo/DOID_12326 chronic pulmonary heart disease http://purl.obolibrary.org/obo/DOID_8515 Cor pulmonale http://purl.obolibrary.org/obo/DOID_8564 lip cancer http://purl.obolibrary.org/obo/DOID_9297 lip disease http://purl.obolibrary.org/obo/DOID_8578 soft palate cancer http://purl.obolibrary.org/obo/DOID_8618 oral cavity cancer http://purl.obolibrary.org/obo/DOID_9149 hard palate cancer http://purl.obolibrary.org/obo/DOID_8618 oral cavity cancer http://purl.obolibrary.org/obo/DOID_251 alcohol-induced mental disorder http://purl.obolibrary.org/obo/DOID_8646 substance-induced psychosis http://purl.obolibrary.org/obo/DOID_1203 drug-induced mental disorder http://purl.obolibrary.org/obo/DOID_8646 substance-induced psychosis http://purl.obolibrary.org/obo/DOID_1803 neuritis http://purl.obolibrary.org/obo/DOID_870 neuropathy http://purl.obolibrary.org/obo/DOID_2477 motor peripheral neuropathy http://purl.obolibrary.org/obo/DOID_870 neuropathy http://purl.obolibrary.org/obo/DOID_7319 axonal neuropathy http://purl.obolibrary.org/obo/DOID_870 neuropathy http://purl.obolibrary.org/obo/DOID_1195 ischemic neuropathy http://purl.obolibrary.org/obo/DOID_870 neuropathy http://purl.obolibrary.org/obo/DOID_2537 inflammatory and toxic neuropathy http://purl.obolibrary.org/obo/DOID_870 neuropathy http://purl.obolibrary.org/obo/DOID_3690 brachial plexus neuropathy http://purl.obolibrary.org/obo/DOID_870 neuropathy http://purl.obolibrary.org/obo/DOID_9743 diabetic neuropathy http://purl.obolibrary.org/obo/DOID_870 neuropathy http://purl.obolibrary.org/obo/DOID_297 pleomorphic adenoma carcinoma http://purl.obolibrary.org/obo/DOID_8850 salivary gland cancer http://purl.obolibrary.org/obo/DOID_5309 epithelial-myoepithelial carcinoma http://purl.obolibrary.org/obo/DOID_8850 salivary gland cancer http://purl.obolibrary.org/obo/DOID_8946 severe nonproliferative diabetic retinopathy http://purl.obolibrary.org/obo/DOID_8947 diabetic retinopathy http://purl.obolibrary.org/obo/DOID_9191 diabetic macular edema http://purl.obolibrary.org/obo/DOID_8947 diabetic retinopathy http://purl.obolibrary.org/obo/DOID_13207 proliferative diabetic retinopathy http://purl.obolibrary.org/obo/DOID_8947 diabetic retinopathy http://purl.obolibrary.org/obo/DOID_1838 Menkes disease http://purl.obolibrary.org/obo/DOID_896 metal metabolism disorder http://purl.obolibrary.org/obo/DOID_1029 familial periodic paralysis http://purl.obolibrary.org/obo/DOID_896 metal metabolism disorder http://purl.obolibrary.org/obo/DOID_4184 pseudohypoparathyroidism http://purl.obolibrary.org/obo/DOID_896 metal metabolism disorder http://purl.obolibrary.org/obo/DOID_2582 acatalasia http://purl.obolibrary.org/obo/DOID_906 peroxisomal disease http://purl.obolibrary.org/obo/DOID_11175 enophthalmos http://purl.obolibrary.org/obo/DOID_930 orbital disease http://purl.obolibrary.org/obo/DOID_11230 acute orbital inflammation http://purl.obolibrary.org/obo/DOID_930 orbital disease http://purl.obolibrary.org/obo/DOID_9461 exposure keratitis http://purl.obolibrary.org/obo/DOID_9368 keratoconjunctivitis http://purl.obolibrary.org/obo/DOID_11581 phlyctenulosis http://purl.obolibrary.org/obo/DOID_9368 keratoconjunctivitis http://purl.obolibrary.org/obo/DOID_12197 punctate epithelial keratoconjunctivitis http://purl.obolibrary.org/obo/DOID_9368 keratoconjunctivitis http://purl.obolibrary.org/obo/DOID_13014 shipyard eye http://purl.obolibrary.org/obo/DOID_9368 keratoconjunctivitis http://purl.obolibrary.org/obo/DOID_11459 pseudotumor cerebri http://purl.obolibrary.org/obo/DOID_9428 intracranial hypertension http://purl.obolibrary.org/obo/DOID_9439 chronic cholangitis http://purl.obolibrary.org/obo/DOID_9446 cholangitis http://purl.obolibrary.org/obo/DOID_14268 sclerosing cholangitis http://purl.obolibrary.org/obo/DOID_9446 cholangitis http://purl.obolibrary.org/obo/DOID_14270 ascending cholangitis http://purl.obolibrary.org/obo/DOID_9446 cholangitis http://purl.obolibrary.org/obo/DOID_14503 neuronal ceroid lipofuscinosis http://purl.obolibrary.org/obo/DOID_9455 lipid storage disease http://purl.obolibrary.org/obo/DOID_350 mastocytosis http://purl.obolibrary.org/obo/DOID_9500 leukocyte disease http://purl.obolibrary.org/obo/DOID_12986 leukostasis http://purl.obolibrary.org/obo/DOID_9500 leukocyte disease http://purl.obolibrary.org/obo/DOID_3947 adrenal gland hyperfunction http://purl.obolibrary.org/obo/DOID_9553 adrenal gland disease http://purl.obolibrary.org/obo/DOID_3952 adrenal cortex disease http://purl.obolibrary.org/obo/DOID_9553 adrenal gland disease http://purl.obolibrary.org/obo/DOID_5222 acute necrotizing encephalitis http://purl.obolibrary.org/obo/DOID_9588 encephalitis http://purl.obolibrary.org/obo/DOID_3512 neurofibrosarcoma http://purl.obolibrary.org/obo/DOID_962 neurofibroma http://purl.obolibrary.org/obo/DOID_9673 ulcerative stomatitis http://purl.obolibrary.org/obo/DOID_9637 stomatitis http://purl.obolibrary.org/obo/DOID_11875 denture stomatitis http://purl.obolibrary.org/obo/DOID_9637 stomatitis http://purl.obolibrary.org/obo/DOID_11771 spontaneous ocular nystagmus http://purl.obolibrary.org/obo/DOID_9650 pathologic nystagmus http://purl.obolibrary.org/obo/DOID_13174 dissociated nystagmus http://purl.obolibrary.org/obo/DOID_9650 pathologic nystagmus http://purl.obolibrary.org/obo/DOID_10471 patellar tendinitis http://purl.obolibrary.org/obo/DOID_971 tendinitis http://purl.obolibrary.org/obo/DOID_14181 calcific tendinitis http://purl.obolibrary.org/obo/DOID_971 tendinitis http://purl.obolibrary.org/obo/DOID_9726 vitreous detachment http://purl.obolibrary.org/obo/DOID_9720 vitreous disease http://purl.obolibrary.org/obo/DOID_11816 vitreous syneresis http://purl.obolibrary.org/obo/DOID_9720 vitreous disease http://purl.obolibrary.org/obo/DOID_10697 chronic endophthalmitis http://purl.obolibrary.org/obo/DOID_9724 purulent endophthalmitis http://purl.obolibrary.org/obo/DOID_13732 panophthalmitis http://purl.obolibrary.org/obo/DOID_9724 purulent endophthalmitis http://purl.obolibrary.org/obo/DOID_2825 nose disease http://purl.obolibrary.org/obo/DOID_974 upper respiratory tract disease http://purl.obolibrary.org/obo/DOID_3225 tracheal disease http://purl.obolibrary.org/obo/DOID_974 upper respiratory tract disease http://purl.obolibrary.org/obo/DOID_786 laryngeal disease http://purl.obolibrary.org/obo/DOID_974 upper respiratory tract disease http://purl.obolibrary.org/obo/DOID_9561 nasopharyngeal disease http://purl.obolibrary.org/obo/DOID_974 upper respiratory tract disease http://purl.obolibrary.org/obo/DOID_9740 postcholecystectomy syndrome http://purl.obolibrary.org/obo/DOID_9741 biliary tract disease http://purl.obolibrary.org/obo/DOID_12237 bile reflux http://purl.obolibrary.org/obo/DOID_9741 biliary tract disease http://purl.obolibrary.org/obo/DOID_4138 bile duct disease http://purl.obolibrary.org/obo/DOID_9741 biliary tract disease http://purl.obolibrary.org/obo/DOID_12337 varicocele http://purl.obolibrary.org/obo/DOID_9742 pelvic varices http://purl.obolibrary.org/obo/DOID_11772 leukocoria http://purl.obolibrary.org/obo/DOID_9799 eye degenerative disease http://purl.obolibrary.org/obo/DOID_9834 hyperopia http://purl.obolibrary.org/obo/DOID_9835 refractive error http://purl.obolibrary.org/obo/DOID_12273 anisometropia http://purl.obolibrary.org/obo/DOID_9835 refractive error http://purl.obolibrary.org/obo/DOID_9839 accommodative esotropia http://purl.obolibrary.org/obo/DOID_9840 esotropia http://purl.obolibrary.org/obo/DOID_9848 endolymphatic hydrops http://purl.obolibrary.org/obo/DOID_9847 peripheral vertigo http://purl.obolibrary.org/obo/DOID_13941 benign paroxysmal positional nystagmus http://purl.obolibrary.org/obo/DOID_9847 peripheral vertigo http://purl.obolibrary.org/obo/DOID_11543 corneal abscess http://purl.obolibrary.org/obo/DOID_9858 deep keratitis http://purl.obolibrary.org/obo/DOID_11727 facioscapulohumeral muscular dystrophy http://purl.obolibrary.org/obo/DOID_9884 muscular dystrophy http://purl.obolibrary.org/obo/DOID_9937 chronic dacryocystitis http://purl.obolibrary.org/obo/DOID_9938 dacryocystitis http://purl.obolibrary.org/obo/DOID_1602 lymphadenitis http://purl.obolibrary.org/obo/DOID_9942 lymph node disease http://purl.obolibrary.org/obo/DOID_11981 morbid obesity http://purl.obolibrary.org/obo/DOID_9970 obesity http://purl.obolibrary.org/obo/CHEBI_101086 EC 5.4.99.7 (lanosterol synthase) inhibitor http://purl.obolibrary.org/obo/CHEBI_101090 EC 5.4.99.* (intramolecular transferase transferring other groups) inhibitor http://purl.obolibrary.org/obo/CHEBI_35481 non-narcotic analgesic http://purl.obolibrary.org/obo/CHEBI_35480 analgesic http://purl.obolibrary.org/obo/CHEBI_50504 osmotic diuretic http://purl.obolibrary.org/obo/CHEBI_35498 diuretic http://purl.obolibrary.org/obo/CHEBI_22333 alkylating agent http://purl.obolibrary.org/obo/CHEBI_25435 mutagen http://purl.obolibrary.org/obo/CHEBI_37334 diagnostic imaging agent http://purl.obolibrary.org/obo/CHEBI_33295 diagnostic agent http://purl.obolibrary.org/obo/CHEBI_23530 cytokinin http://purl.obolibrary.org/obo/CHEBI_37848 plant hormone http://purl.obolibrary.org/obo/CHEBI_24937 jasmonates http://purl.obolibrary.org/obo/CHEBI_37848 plant hormone http://purl.obolibrary.org/obo/CHEBI_51268 drying control chemical additive http://purl.obolibrary.org/obo/CHEBI_46787 solvent http://purl.obolibrary.org/obo/CHEBI_51452 endothelin A receptor antagonist http://purl.obolibrary.org/obo/CHEBI_51451 endothelin receptor antagonist http://www.ebi.ac.uk/efo/EFO_0001323 obsolete_fetus http://purl.obolibrary.org/obo/UBERON_0000068 embryo stage http://www.ebi.ac.uk/efo/EFO_0001291 gastrula 50%-epiboly http://purl.obolibrary.org/obo/UBERON_0000109 gastrula stage http://www.ebi.ac.uk/efo/EFO_0001292 gastrula 75%-epiboly http://purl.obolibrary.org/obo/UBERON_0000109 gastrula stage http://www.ebi.ac.uk/efo/EFO_0001293 gastrula 90%-epiboly http://purl.obolibrary.org/obo/UBERON_0000109 gastrula stage http://www.ebi.ac.uk/efo/EFO_0002560 gastrula 80%-epiboly http://purl.obolibrary.org/obo/UBERON_0000109 gastrula stage http://www.bioassayontology.org/bao#BAO_0002658 counts per second http://www.bioassayontology.org/bao#BAO_0000077 unit of measurement http://www.bioassayontology.org/bao#BAO_0080022 log change http://purl.obolibrary.org/obo/UO_0000190 ratio http://purl.obolibrary.org/obo/DOID_14497 Wolman disease http://purl.obolibrary.org/obo/DOID_0080217 lysosomal and lipase deficiency http://purl.obolibrary.org/obo/DOID_14502 cholesterol ester storage disease http://purl.obolibrary.org/obo/DOID_0080217 lysosomal and lipase deficiency http://purl.obolibrary.org/obo/CHEBI_130181 calmodulin antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist http://www.bioassayontology.org/bao#BAO_0001223 3H http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0001224 35S http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0001234 ACP-tag http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://purl.obolibrary.org/obo/CHEBI_76969 bacterial metabolite http://purl.obolibrary.org/obo/CHEBI_75787 prokaryotic metabolite http://www.bioassayontology.org/bao#BAO_0002515 Raman imaging http://www.bioassayontology.org/bao#BAO_0002513 vibrational spectroscopic imaging http://www.bioassayontology.org/bao#BAO_0002516 infrared imaging http://www.bioassayontology.org/bao#BAO_0002513 vibrational spectroscopic imaging http://www.bioassayontology.org/bao#BAO_0002306 linear QSAR http://www.bioassayontology.org/bao#BAO_0002305 quantitative structure activity relationship analysis http://www.bioassayontology.org/bao#BAO_0002309 non-linear QSAR http://www.bioassayontology.org/bao#BAO_0002305 quantitative structure activity relationship analysis http://www.bioassayontology.org/bao#BAO_0002316 two dimensional QSAR http://www.bioassayontology.org/bao#BAO_0002305 quantitative structure activity relationship analysis http://purl.obolibrary.org/obo/NCBITaxon_469 Acinetobacter http://www.bioassayontology.org/bao#BAO_0000364 bacterium http://purl.obolibrary.org/obo/NCBITaxon_6183 Schistosoma mansoni http://www.bioassayontology.org/bao#BAO_0000511 invertebrate http://www.bioassayontology.org/bao#BAO_0000607 sea urchin http://www.bioassayontology.org/bao#BAO_0000511 invertebrate http://www.bioassayontology.org/bao#BAO_0002639 Chlorocebus aethiops http://www.bioassayontology.org/bao#BAO_0000362 mammalian http://purl.obolibrary.org/obo/NCBITaxon_11082 West Nile virus http://www.bioassayontology.org/bao#BAO_0000232 virus http://www.bioassayontology.org/bao#BAO_0000636 influenza virus http://www.bioassayontology.org/bao#BAO_0000232 virus http://www.bioassayontology.org/bao#BAO_0002657 Infectious bronchitis virus http://www.bioassayontology.org/bao#BAO_0000232 virus http://www.bioassayontology.org/bao#BAO_0000712 Epstein-Barr virus http://www.bioassayontology.org/bao#BAO_0000232 virus http://www.bioassayontology.org/bao#BAO_0002235 DIALIGN sequence alignment http://www.bioassayontology.org/bao#BAO_0002245 multiple sequence alignment http://www.bioassayontology.org/bao#BAO_0002471 fluorescent DNA hydrolysis probe method http://www.bioassayontology.org/bao#BAO_0002470 fluorescent DNA hybridization probe method http://www.bioassayontology.org/bao#BAO_0002356 GSEA-P enrichment analysis http://www.bioassayontology.org/bao#BAO_0002354 gene list enrichment analysis http://www.bioassayontology.org/bao#BAO_0002357 GeneTrail enrichment analysis http://www.bioassayontology.org/bao#BAO_0002354 gene list enrichment analysis http://www.bioassayontology.org/bao#BAO_0002358 Onto-Express enrichment analysis http://www.bioassayontology.org/bao#BAO_0002354 gene list enrichment analysis http://www.bioassayontology.org/bao#BAO_0002355 GOstat enrichment analysis http://www.bioassayontology.org/bao#BAO_0002354 gene list enrichment analysis http://www.bioassayontology.org/bao#BAO_0002777 beta galactosidase enzyme activity assay http://www.bioassayontology.org/bao#BAO_0002806 generic hydrolase enzyme activity assay http://www.bioassayontology.org/bao#BAO_0002802 fold decrease http://www.bioassayontology.org/bao#BAO_0000193 fold change http://www.bioassayontology.org/bao#BAO_0002801 fold increase http://www.bioassayontology.org/bao#BAO_0000193 fold change http://www.bioassayontology.org/bao#BAO_0002265 shape fingerprint search http://www.bioassayontology.org/bao#BAO_0002264 3D structure similarity search http://www.bioassayontology.org/bao#BAO_0002267 topomer search http://www.bioassayontology.org/bao#BAO_0002264 3D structure similarity search http://www.bioassayontology.org/bao#BAO_0001250 maximal effect http://www.bioassayontology.org/bao#BAO_0000656 efficacy http://www.bioassayontology.org/bao#BAO_0002109 Mitogen-activated protein kinase 14 http://www.bioassayontology.org/bao#BAO_0000294 kinase http://www.bioassayontology.org/bao#BAO_0002789 Mitogen-activated protein kinase 1 http://www.bioassayontology.org/bao#BAO_0000294 kinase http://www.bioassayontology.org/bao#BAO_0002273 GROW structure design http://www.bioassayontology.org/bao#BAO_0002272 de novo structure design http://www.bioassayontology.org/bao#BAO_0002274 Groupbuild structure design http://www.bioassayontology.org/bao#BAO_0002272 de novo structure design http://www.bioassayontology.org/bao#BAO_0002275 LEGEND structure design http://www.bioassayontology.org/bao#BAO_0002272 de novo structure design http://www.bioassayontology.org/bao#BAO_0002276 LUDI structure design http://www.bioassayontology.org/bao#BAO_0002272 de novo structure design http://www.bioassayontology.org/bao#BAO_0002277 SPROUT structure design http://www.bioassayontology.org/bao#BAO_0002272 de novo structure design http://www.bioassayontology.org/bao#BAO_0002352 Ariadne Pathway Studio http://www.bioassayontology.org/bao#BAO_0002351 natural language processing http://www.bioassayontology.org/bao#BAO_0002396 FLOG scoring function http://www.bioassayontology.org/bao#BAO_0002394 empirical scoring function http://www.bioassayontology.org/bao#BAO_0002395 AutoDock3 scoring function http://www.bioassayontology.org/bao#BAO_0002394 empirical scoring function http://www.bioassayontology.org/bao#BAO_0002397 GOLD scoring function http://www.bioassayontology.org/bao#BAO_0002394 empirical scoring function http://purl.obolibrary.org/obo/CHEBI_33232 application http://www.bioassayontology.org/bao#BAO_0002929 role http://purl.obolibrary.org/obo/CHEBI_51086 chemical role http://www.bioassayontology.org/bao#BAO_0002929 role http://www.bioassayontology.org/bao#BAO_0002900 researcher role http://www.bioassayontology.org/bao#BAO_0002929 role http://www.bioassayontology.org/bao#BAO_0110000 chemical role http://www.bioassayontology.org/bao#BAO_0002929 role http://www.bioassayontology.org/bao#BAO_0110001 application http://www.bioassayontology.org/bao#BAO_0002929 role http://www.bioassayontology.org/bao#BAO_0110002 biological role http://www.bioassayontology.org/bao#BAO_0002929 role http://purl.obolibrary.org/obo/PATO_0000068 qualitative http://www.bioassayontology.org/bao#BAO_0002928 quality http://www.bioassayontology.org/bao#BAO_0120000 cellular quality http://www.bioassayontology.org/bao#BAO_0002928 quality http://www.bioassayontology.org/bao#BAO_0120001 molecular quality http://www.bioassayontology.org/bao#BAO_0002928 quality http://www.bioassayontology.org/bao#BAO_0120002 organismal quality http://www.bioassayontology.org/bao#BAO_0002928 quality http://www.bioassayontology.org/bao#BAO_0120003 physical quality http://www.bioassayontology.org/bao#BAO_0002928 quality http://www.bioassayontology.org/bao#BAO_0000101 log10 molar http://www.bioassayontology.org/bao#BAO_0000077 unit of measurement http://www.bioassayontology.org/bao#BAO_0000102 negative log10 molar http://www.bioassayontology.org/bao#BAO_0000077 unit of measurement http://www.bioassayontology.org/bao#BAO_0002842 Gram positive http://www.bioassayontology.org/bao#BAO_0002844 Gram staining http://www.bioassayontology.org/bao#BAO_0002843 Gram negative http://www.bioassayontology.org/bao#BAO_0002844 Gram staining http://www.bioassayontology.org/bao#BAO_0000750 Beta-galactosidase http://www.bioassayontology.org/bao#BAO_0000222 generic hydrolase http://www.bioassayontology.org/bao#BAO_0000751 Beta-lactamase http://www.bioassayontology.org/bao#BAO_0000222 generic hydrolase http://www.bioassayontology.org/bao#BAO_0003049 Caspase-3 http://www.bioassayontology.org/bao#BAO_0000222 generic hydrolase http://www.bioassayontology.org/bao#BAO_0002444 gene overexpression by transient transfection http://www.bioassayontology.org/bao#BAO_0002442 gene overexpression http://www.bioassayontology.org/bao#BAO_0002443 gene overexpression by stable transfection http://www.bioassayontology.org/bao#BAO_0002442 gene overexpression http://www.bioassayontology.org/bao#BAO_0002470 fluorescent DNA hybridization probe method http://www.bioassayontology.org/bao#BAO_0002469 fluorescent labeling method http://www.bioassayontology.org/bao#BAO_0002477 fluorescent dye transfer http://www.bioassayontology.org/bao#BAO_0002469 fluorescent labeling method http://www.bioassayontology.org/bao#BAO_0002472 fluorescent DNA intercalation method http://www.bioassayontology.org/bao#BAO_0002469 fluorescent labeling method http://www.bioassayontology.org/bao#BAO_0002217 computational structure solution http://www.bioassayontology.org/bao#BAO_0002216 3D structure prediction http://www.bioassayontology.org/bao#BAO_0002226 protein-protein docking http://www.bioassayontology.org/bao#BAO_0002216 3D structure prediction http://www.bioassayontology.org/bao#BAO_0002286 CHARMM force field simulation http://www.bioassayontology.org/bao#BAO_0002284 classical force field simulation http://www.bioassayontology.org/bao#BAO_0002214 PREDATOR structure prediction http://www.bioassayontology.org/bao#BAO_0002213 2D structure prediction http://www.bioassayontology.org/bao#BAO_0002215 PredictProtein structure prediction http://www.bioassayontology.org/bao#BAO_0002213 2D structure prediction http://www.bioassayontology.org/bao#BAO_0000042 Cue Signal Response assay http://www.bioassayontology.org/bao#BAO_0003002 signal transduction assay http://www.bioassayontology.org/bao#BAO_0002262 MACCS key http://www.bioassayontology.org/bao#BAO_0002261 2D structure similarity search http://www.bioassayontology.org/bao#BAO_0002263 circular fingerprint search http://www.bioassayontology.org/bao#BAO_0002261 2D structure similarity search http://www.bioassayontology.org/bao#BAO_0002542 cell phenotype http://www.bioassayontology.org/bao#BAO_0003114 assay biology component http://www.bioassayontology.org/bao#BAO_0002927 disease http://www.bioassayontology.org/bao#BAO_0003114 assay biology component http://www.bioassayontology.org/bao#BAO_0002930 anatomical entity http://www.bioassayontology.org/bao#BAO_0003114 assay biology component http://www.bioassayontology.org/bao#BAO_0002931 cell line cell http://www.bioassayontology.org/bao#BAO_0003114 assay biology component http://www.bioassayontology.org/bao#BAO_0003016 binding site http://www.bioassayontology.org/bao#BAO_0003114 assay biology component http://www.bioassayontology.org/bao#BAO_0003111 biological macromolecule http://www.bioassayontology.org/bao#BAO_0003114 assay biology component http://www.bioassayontology.org/bao#BAO_0003117 function http://www.bioassayontology.org/bao#BAO_0003114 assay biology component http://www.bioassayontology.org/bao#BAO_0002810 physicochemical http://www.bioassayontology.org/bao#BAO_0000008 bioassay type http://www.bioassayontology.org/bao#BAO_0002552 tagged http://www.bioassayontology.org/bao#BAO_0000013 primary structure http://www.bioassayontology.org/bao#BAO_0002167 genotoxicity assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay http://www.bioassayontology.org/bao#BAO_0002765 organism behavior assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay http://www.bioassayontology.org/bao#BAO_0002041 cell cycle assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay http://www.bioassayontology.org/bao#BAO_0002100 cell growth assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay http://www.bioassayontology.org/bao#BAO_0002168 oxidative stress assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay http://www.bioassayontology.org/bao#BAO_0002181 oxidative phosphorylation assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay http://www.bioassayontology.org/bao#BAO_0002189 toxicity assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay http://www.bioassayontology.org/bao#BAO_0002196 localization assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay http://www.bioassayontology.org/bao#BAO_0002535 metastasis assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay http://www.bioassayontology.org/bao#BAO_0002761 chaperone activity assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay http://www.bioassayontology.org/bao#BAO_0002778 cell permeability assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay http://www.bioassayontology.org/bao#BAO_0002779 protein unfolding assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay http://www.bioassayontology.org/bao#BAO_0002804 protein stability assay http://www.bioassayontology.org/bao#BAO_0000015 bioassay http://www.bioassayontology.org/bao#BAO_0002038 conformation http://www.bioassayontology.org/bao#BAO_0000020 tertiary structure http://www.bioassayontology.org/bao#BAO_0002169 assay readout content http://www.bioassayontology.org/bao#BAO_0000026 bioassay specification http://www.bioassayontology.org/bao#BAO_0000024 fluorescently labeled http://www.bioassayontology.org/bao#BAO_0000037 labeled http://www.bioassayontology.org/bao#BAO_0000036 radiolabeled http://www.bioassayontology.org/bao#BAO_0000037 labeled http://www.bioassayontology.org/bao#BAO_0002529 atomic absorption spectrophotometry http://www.bioassayontology.org/bao#BAO_0000049 spectrophotometry method http://www.bioassayontology.org/bao#BAO_0002841 off plate control http://www.bioassayontology.org/bao#BAO_0000072 assay control http://www.bioassayontology.org/bao#BAO_0002840 on plate control http://www.bioassayontology.org/bao#BAO_0000072 assay control http://www.bioassayontology.org/bao#BAO_0080004 phenotypic mode of action http://www.bioassayontology.org/bao#BAO_0000074 mode of action http://www.bioassayontology.org/bao#BAO_0190001 ratio http://www.bioassayontology.org/bao#BAO_0000077 unit of measurement http://www.bioassayontology.org/bao#BAO_0080019 rate http://www.bioassayontology.org/bao#BAO_0000077 unit of measurement http://www.bioassayontology.org/bao#BAO_0190002 temperature unit http://www.bioassayontology.org/bao#BAO_0000077 unit of measurement http://www.bioassayontology.org/bao#BAO_0190003 time unit http://www.bioassayontology.org/bao#BAO_0000077 unit of measurement http://www.bioassayontology.org/bao#BAO_0001251 Increase http://www.bioassayontology.org/bao#BAO_0000082 percent response http://www.bioassayontology.org/bao#BAO_0001252 percent change http://www.bioassayontology.org/bao#BAO_0000082 percent response http://www.bioassayontology.org/bao#BAO_0001253 percent growth http://www.bioassayontology.org/bao#BAO_0000082 percent response http://www.bioassayontology.org/bao#BAO_0001254 percent protection http://www.bioassayontology.org/bao#BAO_0000082 percent response http://www.bioassayontology.org/bao#BAO_0001255 percent remaining http://www.bioassayontology.org/bao#BAO_0000082 percent response http://www.bioassayontology.org/bao#BAO_0001256 uptake http://www.bioassayontology.org/bao#BAO_0000082 percent response http://www.bioassayontology.org/bao#BAO_0002902 agonism http://www.bioassayontology.org/bao#BAO_0000084 ligand function mode of action http://www.bioassayontology.org/bao#BAO_0002903 antagonism http://www.bioassayontology.org/bao#BAO_0000084 ligand function mode of action http://www.bioassayontology.org/bao#BAO_0002909 modulation http://www.bioassayontology.org/bao#BAO_0000084 ligand function mode of action http://www.bioassayontology.org/bao#BAO_0002906 partial activation http://www.bioassayontology.org/bao#BAO_0000087 activation http://www.bioassayontology.org/bao#BAO_0002914 full activation http://www.bioassayontology.org/bao#BAO_0000087 activation http://www.bioassayontology.org/bao#BAO_0002905 allosteric inhibition http://www.bioassayontology.org/bao#BAO_0000091 inhibition http://www.bioassayontology.org/bao#BAO_0080018 reversible inhibition http://www.bioassayontology.org/bao#BAO_0000091 inhibition http://www.bioassayontology.org/bao#BAO_0001106 50 percent growth inhibition http://www.bioassayontology.org/bao#BAO_0000096 percent growth inhibition http://www.bioassayontology.org/bao#BAO_0001108 100 percent growth inhibition http://www.bioassayontology.org/bao#BAO_0000096 percent growth inhibition http://www.bioassayontology.org/bao#BAO_0000115 Hoechst 33342 http://www.bioassayontology.org/bao#BAO_0000116 Hoechst http://www.bioassayontology.org/bao#BAO_0002892 second messenger competitive binding assessment method http://www.bioassayontology.org/bao#BAO_0000123 binding assessment method http://www.bioassayontology.org/bao#BAO_0002755 fluorescent ligand binding method http://www.bioassayontology.org/bao#BAO_0000123 binding assessment method http://www.bioassayontology.org/bao#BAO_0002888 ion redistribution determination method http://www.bioassayontology.org/bao#BAO_0000126 molecular redistribution determination method http://www.bioassayontology.org/bao#BAO_0000014 secondary structure http://www.bioassayontology.org/bao#BAO_0000138 molecular structure http://www.bioassayontology.org/bao#BAO_0000020 tertiary structure http://www.bioassayontology.org/bao#BAO_0000138 molecular structure http://www.bioassayontology.org/bao#BAO_0002734 luciferase enzyme activity measurement method http://www.bioassayontology.org/bao#BAO_0000139 direct enzyme activity measurement method http://www.bioassayontology.org/bao#BAO_0002591 chaperone coupled enzyme activity measurement method http://www.bioassayontology.org/bao#BAO_0000142 coupled enzyme activity measurement method http://www.bioassayontology.org/bao#BAO_0002592 protease coupled enzyme activity measurement method http://www.bioassayontology.org/bao#BAO_0000142 coupled enzyme activity measurement method http://www.bioassayontology.org/bao#BAO_0002593 substrate coupled enzyme activity measurement method http://www.bioassayontology.org/bao#BAO_0000142 coupled enzyme activity measurement method http://www.bioassayontology.org/bao#BAO_0002730 cofactor coupled enzyme activity measurement method http://www.bioassayontology.org/bao#BAO_0000142 coupled enzyme activity measurement method http://www.bioassayontology.org/bao#BAO_0001020 Sphingosine 1-phosphate http://www.bioassayontology.org/bao#BAO_0000171 lipid http://www.bioassayontology.org/bao#BAO_0030000 Histone H3.3 http://www.bioassayontology.org/bao#BAO_0000175 protein http://www.bioassayontology.org/bao#BAO_0002758 volume endpoint http://www.bioassayontology.org/bao#BAO_0000179 endpoint http://www.bioassayontology.org/bao#BAO_0080028 quantified endpoint http://www.bioassayontology.org/bao#BAO_0000179 endpoint http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint http://www.bioassayontology.org/bao#BAO_0000180 concentration endpoint http://www.bioassayontology.org/bao#BAO_0020002 liposome format http://www.bioassayontology.org/bao#BAO_0000220 subcellular format http://www.bioassayontology.org/bao#BAO_0030006 E-selectin http://www.bioassayontology.org/bao#BAO_0000237 adhesion http://www.bioassayontology.org/bao#BAO_0030011 primary neuron http://www.bioassayontology.org/bao#BAO_0000239 primary cell http://www.bioassayontology.org/bao#BAO_0003091 Fluo-4 Calcium Assay Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002727 ELISA cAMP Competition Assay using cAMP-Screen Direct System http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000948 IP-One HTRF Assay http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000814 Adapta Universal Kinase Assay Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000937 HTRF cAMP Detection Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002980 Cellomics c-Jun Activation Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000815 ADP Hunter Plus http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002567 ECL peptide assay http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002985 Cellomics Multiplexed p53 and p21 Detection Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000923 GeneBLAzer http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0003082 HTRF biomarkers http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000942 HTScan PKC-theta Kinase Assay Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0140001 PathScan Apoptosis and Proliferation Multiplex IF Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0003083 ViaLight Plus kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002564 AlphaScreen IgG detection kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000216 steadylite HTS Reagent http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000307 PKLight http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000816 Amplex Red Glucose/Glucose Oxidase Assay Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000898 cAMP-screen direct system http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000908 Fluo-8 No Wash Calcium Assay Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000917 FluxOR Thallium Detection Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000936 High Performance PBX Calcium Assay Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000938 HTRF cAMP HiRange Detection Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000939 HTRF KinEASE-TK http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000940 HTScan IKK-beta Kinase Assay Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000941 HTScan PKC-beta Kinase Assay Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000953 LANCE cAMP Detection Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000958 LiveBLAzer FRET - B/G Loading Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000983 OptEIA Human IL-8 ELISA Set http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000988 PathHunter Beta-Arrestin Assay http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0001025 Tango GPCR Assay System http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0001200 Transcreener assay kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0001201 Lactate kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0001202 TruPoint assay kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002561 FLIPR Calcium 3 Assay Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002563 lance TR-FRET kinase assay kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002565 AlphaScreen GST detection kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002566 AlphaScreen cAMP assay kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002728 Vybrant MTT Cell Proliferation Assay Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002732 Phospho(Thr180/Tyr182)/Total p38 Assay Whole Cell Lysate Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002974 Cellomics Beta-Catenin Activation Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002975 Cellomics BrdU and Ki67 Cell Proliferation Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002976 Cellomics Caspase3 Activation Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002977 Cellomics Caspase9 Activation Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002978 Cellomics Cell Motility Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002979 Cellomics Cell Viability Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002981 Cellomics Cytoskeletal Rearrangement Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002982 Cellomics Mitotic Index Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002983 Cellomics Multiparameter Cytotoxicity 1 Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002984 Cellomics Multiplexed NFκB and c-Jun Activation Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002986 Cellomics p38 MAPK Activation Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0003077 HitHunter Calcium No WashPLUS Assay Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0003078 HitHunter cAMP Assay Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0003079 AlphaScreen Phosphotyrosine Assay Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0003080 AlphaScreen cGMP Detection http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0003081 Alphascreen second messenger IP1 detection kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0003084 QuantiChrom Assay Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0003086 LanthaScreen Competetive Binding Assay http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0003087 FLIPR Calcium 5 Assay Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0003089 CyQUANT Cell Proliferation Assay Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0003090 HTRF KinEASE http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0003092 Calcium Assay Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0140003 PathScan EMT Duplex IF Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0140004 PathScan Multi-Target HCA DNA Damage Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0140005 PathScan Multi-Target HCA Stress and Apoptosis Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0140006 PathScan Signaling Nodes Multiplex IF Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0140007 StemLight Pluripotency Antibody Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0140019 Reverse Transcription Kit (Applied Biosystems or ABI) http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0140023 OptEIA human IL-2 ELISA (BD Biosciences) http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0003109 KINOMEscan kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0003085 LanthaScreen Co-Factor Interaction Assay http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0140002 PathScan EGF Receptor Activation Multiplex IF Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000873 Calcium 5 Assay Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0003076 PolarScreen Competitor Assay Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000689 ATPLite Luminescence Assay System http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000686 britelite plus http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0003088 FLIPR Membrane Potential Assay Kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002562 LanthaScreen kinase activity assay kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002018 xMap kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0002540 ECL western blotting detection kit http://www.bioassayontology.org/bao#BAO_0000248 assay kit http://www.bioassayontology.org/bao#BAO_0000718 CD40 http://www.bioassayontology.org/bao#BAO_0000285 transmembrane receptor http://www.bioassayontology.org/bao#BAO_0000719 CD4-TLR4 http://www.bioassayontology.org/bao#BAO_0000285 transmembrane receptor http://www.bioassayontology.org/bao#BAO_0002546 HA tag http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0001052 Z-Arg-Arg-AMC http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000909 fMLFK-FITC http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000833 Ac-DEVD-AFC http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000793 Suc-LLVY-aminoluciferin http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000828 [125I]Y10-neuropeptide S http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000965 Melanin-concentrating hormone http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0003050 DEVD-NucView 488 http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0001034 Thyrotropin-releasing hormone http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000836 Ac-WEHD-AFC http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000888 DABCYL-Thr-Pro-Leu-Lys~Ser-Pro-Pro-Pro-Ser-Pro-Arg-EDANS http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000865 Boc-Leu-Gly-Arg-AMC http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000821 14LckpCAP394 peptide http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000835 Ac-LEHD-AMC http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000745 FITC-RGS12-GoLoco peptide http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000783 DYRKtide peptide http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000785 Kemptide peptide http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000794 Z-RLRGG-aminoluciferin http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000849 Apelin-13 http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000864 Boc-Gln-Gly-Arg-AMC http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000866 Boc-Val-Pro-Arg-AMC http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000896 Dy647-pS136-Bad peptide http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000912 Fluorogenic triple-helical peptide 3 http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000920 Galanin http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000934 H-Leu-NHMec http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000970 Muramyl dipeptide http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000974 Neuropeptide W http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000975 Neuropeptide S http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000976 Neuropeptide Y http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000984 Orexin A http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0001002 Pyr-RTKR-AMC http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0001011 Rhodamine-RGS12-GoLoco peptide http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0001014 RS repeat peptide http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0001023 Suc-Ala-Ala-Pro-Phe-AMC http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0001035 TMR-pS259-Raf peptide http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0001042 ULight poly-GT http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0001053 Z-Phe-Arg-AMC http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0002544 his tag http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0003057 Glutathione http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0002545 myc tag http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000792 S6 peptide http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0000985 Oxytocin http://www.bioassayontology.org/bao#BAO_0000325 peptide http://www.bioassayontology.org/bao#BAO_0002076 extraction from natural source http://www.bioassayontology.org/bao#BAO_0003029 small molecule preparation method http://www.bioassayontology.org/bao#BAO_0002077 synthesis by a chemical process http://www.bioassayontology.org/bao#BAO_0003029 small molecule preparation method http://www.bioassayontology.org/bao#BAO_0000766 NOD1 http://www.bioassayontology.org/bao#BAO_0000365 cytosolic protein http://www.bioassayontology.org/bao#BAO_0001039 Ubiquitin-AMC http://www.bioassayontology.org/bao#BAO_0000365 cytosolic protein http://www.bioassayontology.org/bao#BAO_0002108 Microtubule-associated protein tau http://www.bioassayontology.org/bao#BAO_0000365 cytosolic protein http://www.bioassayontology.org/bao#BAO_0001040 Ubiquitin-Rho http://www.bioassayontology.org/bao#BAO_0000365 cytosolic protein http://www.bioassayontology.org/bao#BAO_0000767 NOD2 http://www.bioassayontology.org/bao#BAO_0000365 cytosolic protein http://www.bioassayontology.org/bao#BAO_0000236 Tumor necrosis factor http://www.bioassayontology.org/bao#BAO_0000369 secreted http://www.bioassayontology.org/bao#BAO_0000771 Thrombopoietin http://www.bioassayontology.org/bao#BAO_0000369 secreted http://www.bioassayontology.org/bao#BAO_0001033 Thyroid-stimulating hormone http://www.bioassayontology.org/bao#BAO_0000369 secreted http://www.bioassayontology.org/bao#BAO_0002163 solid phase http://www.bioassayontology.org/bao#BAO_0000372 homogeneous phase http://www.bioassayontology.org/bao#BAO_0002164 liquid phase http://www.bioassayontology.org/bao#BAO_0000372 homogeneous phase http://www.bioassayontology.org/bao#BAO_0002780 IP1 redistribution assay http://www.bioassayontology.org/bao#BAO_0000379 second messenger redistribution assay http://www.bioassayontology.org/bao#BAO_0002512 scanning near-field optical microscopy http://www.bioassayontology.org/bao#BAO_0000451 optical microscopy http://www.bioassayontology.org/bao#BAO_0002513 vibrational spectroscopic imaging http://www.bioassayontology.org/bao#BAO_0000451 optical microscopy http://www.bioassayontology.org/bao#BAO_0002510 dark field microscopy http://www.bioassayontology.org/bao#BAO_0000451 optical microscopy http://www.bioassayontology.org/bao#BAO_0002511 differential interference contrast microscopy http://www.bioassayontology.org/bao#BAO_0000451 optical microscopy http://www.bioassayontology.org/bao#BAO_0002525 tomography http://www.bioassayontology.org/bao#BAO_0000452 imaging method http://www.bioassayontology.org/bao#BAO_0002526 microscopy http://www.bioassayontology.org/bao#BAO_0000452 imaging method http://www.bioassayontology.org/bao#BAO_0002523 atomic force microscopy http://www.bioassayontology.org/bao#BAO_0000459 scanning probe microscopy http://www.bioassayontology.org/bao#BAO_0002524 scanning tunneling microscopy http://www.bioassayontology.org/bao#BAO_0000459 scanning probe microscopy http://www.bioassayontology.org/bao#BAO_0002422 immunoblot http://www.bioassayontology.org/bao#BAO_0000466 ex situ immunoassay http://www.bioassayontology.org/bao#BAO_0002428 radioimmunoassay http://www.bioassayontology.org/bao#BAO_0000466 ex situ immunoassay http://www.bioassayontology.org/bao#BAO_0001490 negative allosteric modulation http://www.bioassayontology.org/bao#BAO_0000489 allosteric modulation http://www.bioassayontology.org/bao#BAO_0001491 positive allosteric modulation http://www.bioassayontology.org/bao#BAO_0000489 allosteric modulation http://www.bioassayontology.org/bao#BAO_0010012 12 well plate http://www.bioassayontology.org/bao#BAO_0000508 microplate http://www.bioassayontology.org/bao#BAO_0010013 6 well plate http://www.bioassayontology.org/bao#BAO_0000508 microplate http://www.bioassayontology.org/bao#BAO_0002192 tissue culture flask http://www.bioassayontology.org/bao#BAO_0000512 assay footprint http://www.bioassayontology.org/bao#BAO_0010014 tube http://www.bioassayontology.org/bao#BAO_0000512 assay footprint http://www.bioassayontology.org/bao#BAO_0010015 microscope slide http://www.bioassayontology.org/bao#BAO_0000512 assay footprint http://www.bioassayontology.org/bao#BAO_0010016 dish http://www.bioassayontology.org/bao#BAO_0000512 assay footprint http://www.bioassayontology.org/bao#BAO_0080025 signal decrease http://www.bioassayontology.org/bao#BAO_0000519 signal direction http://www.bioassayontology.org/bao#BAO_0080026 signal increase http://www.bioassayontology.org/bao#BAO_0000519 signal direction http://www.bioassayontology.org/bao#BAO_0002177 concentration throughput http://www.bioassayontology.org/bao#BAO_0000532 assay measurement throughput http://www.bioassayontology.org/bao#BAO_0002178 repetition throughput http://www.bioassayontology.org/bao#BAO_0000532 assay measurement throughput http://www.bioassayontology.org/bao#BAO_0002925 plasmid DNA construct http://www.bioassayontology.org/bao#BAO_0000550 DNA construct http://www.bioassayontology.org/bao#BAO_0002628 instrumentation manufacturer http://www.bioassayontology.org/bao#BAO_0002624 commercial vendor http://www.bioassayontology.org/bao#BAO_0001258 Kinactivation http://www.bioassayontology.org/bao#BAO_0000587 binding constant http://www.bioassayontology.org/bao#BAO_0002809 Ka http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint http://www.bioassayontology.org/bao#BAO_0000616 IUPHAR http://www.bioassayontology.org/bao#BAO_0000612 assay repository http://www.bioassayontology.org/bao#BAO_0000735 DIVERSet http://www.bioassayontology.org/bao#BAO_0000648 compound library http://www.bioassayontology.org/bao#BAO_0002655 The NatProd Collection http://www.bioassayontology.org/bao#BAO_0000648 compound library http://www.bioassayontology.org/bao#BAO_0000733 MLSMR library http://www.bioassayontology.org/bao#BAO_0000648 compound library http://www.bioassayontology.org/bao#BAO_0000734 LOPAC 1280 http://www.bioassayontology.org/bao#BAO_0000648 compound library http://www.bioassayontology.org/bao#BAO_0000752 NINDS library http://www.bioassayontology.org/bao#BAO_0000648 compound library http://www.bioassayontology.org/bao#BAO_0002527 autoradiography http://www.bioassayontology.org/bao#BAO_0000657 radiometry method http://www.bioassayontology.org/bao#BAO_0002039 shRNA library http://www.bioassayontology.org/bao#BAO_0000661 perturbagen library http://www.bioassayontology.org/bao#BAO_0000957 lithium chloride http://www.bioassayontology.org/bao#BAO_0000666 metal salt http://www.bioassayontology.org/bao#BAO_0000703 HTFC Screening System http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0002724 AMINCO-Bowman Series 2 Luminescence Spectrometer http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000726 Packard Fusion Microplate Reader http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0002574 AlphaQuest reader http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0002571 IN Cell Analyzer http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0002723 MSD SECTOR instrument http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0002572 Epic reader http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0002556 ICRM12000 atomic absorption spectrometer http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000702 FLx800 Fluorescence Microplate Reader http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000878 CCD Luminometer http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000981 Odyssey Infrared Imager http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000701 EnVision Multilabel Reader http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000700 ELx808 Absorbance Microplate Reader http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0003093 ICR 8000 Ion Channel Reader http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0001019 SpectraMax 190 Microplate Reader http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000707 VICTOR X2 Multilabel Plate Reader http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000904 FDSS7000 http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000906 FLIPR TETRA http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000691 ViewLux ultraHTS Microplate Imager http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000699 Analyst HT http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000705 PHERAstar Plus http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000706 SpectraMax M5 Multi-Mode Microplate Reader http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000708 VP-ITC Isothermal Titration Calorimeter http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000727 Infinite PF200 http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000728 Monolight 2010 Luminometer http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000857 AxioVert 200M Fluorescence Light Microscope http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000903 FDSS6000 http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000905 FlexStation II Microplate Reader http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000913 Fluorometer http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000943 HyperCyt High Throughput Flow Cytometry System http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000971 Mx3005P qPCR System http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0001036 TopCount NXT Microplate Scintillation Luminescence Counter http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0001046 ViewLux CCD Imager http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0001048 Wallac MicroBeta Liquid Scintillation Counter http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0002557 Sector imager 6000 http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0002569 LabChip EZ Reader http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0002570 Cellomics ArrayScan http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0002573 Applied biosystems 8200 http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0002575 LJL reader http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0002576 IonWorks Quattro http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0002577 RapidFire Mass Spec http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0002578 Tecan Ultra http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0002719 Avance III http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0002722 CyAn Flow Cytometer http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0002733 HPLC System http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0002935 automated cytometer http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0003095 SpectraMax Plus384 http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0003096 LabChip 3000 http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0003097 Safire http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0003098 Infinite F500 http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0003099 Infinite M1000 http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0003100 LEADseeker Imaging system http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0150008 microscope http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0150070 VE-2 whole-cell patch clamp amplifier (Alembic Instruments) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0150072 SpectraMax Gemini XS microplate fluorometer (Molecular Devices) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0150073 Typhoon FLA 9000 laser scanner (GE Healthcare) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0150074 Fluoroskan Ascent FL Microplate Fluorometer and Luminometer (ThermoFisher) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0150076 Infinte M200 plate reader (Tecan) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0150077 Multiskan EX plate reader (Thermo Scientific) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0150078 Wallac 1420 (Victor2) Microplate reader (PerkinElmer) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0150079 SpectraFluor Plus Microplate Reader (Tecan) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0150080 TSQ Quantum Triple Quadrupole LC-MS (Thermo Scientific) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0150084 BD FACSAria flow cytometer (BD Biosciences) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0150087 FACScalibur flow cytometer (BD Biosciences) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0150088 FLUOstar Omega microplate reader (BMG Labtech) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0150089 Pico patch clamp amplifier (Tecella) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0150091 Varioskan LUX multimode microplate reader (ThermoFisher) http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0150092 Velos-MS http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0001045 VICTOR X3 Multilabel Plate Reader http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000698 8453 UV-Visible Spectrophotometer http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000850 API 4000 LC/MS/MS System http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0000982 Opera QEHS http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0003094 MicroBeta TriLux http://www.bioassayontology.org/bao#BAO_0000697 detection instrument http://www.bioassayontology.org/bao#BAO_0150094 Odyssey Plate Reader http://www.bioassayontology.org/bao#BAO_0000699 Analyst HT http://www.bioassayontology.org/bao#BAO_0003110 HMS http://www.bioassayontology.org/bao#BAO_0000709 research institute http://www.bioassayontology.org/bao#BAO_0000543 orthogonal assay design http://www.bioassayontology.org/bao#BAO_0000806 alternate confirmatory assay http://www.bioassayontology.org/bao#BAO_0000022 endogenous ligand http://www.bioassayontology.org/bao#BAO_0000818 biological ligand http://www.bioassayontology.org/bao#BAO_0000023 synthetic small molecule ligand http://www.bioassayontology.org/bao#BAO_0000818 biological ligand http://www.bioassayontology.org/bao#BAO_0002807 percent mitotic arrested cells http://www.bioassayontology.org/bao#BAO_0001103 percent activity http://www.bioassayontology.org/bao#BAO_0080013 percent neurite outgrowth http://www.bioassayontology.org/bao#BAO_0001103 percent activity http://www.bioassayontology.org/bao#BAO_0080014 percent neurite count http://www.bioassayontology.org/bao#BAO_0001103 percent activity http://www.bioassayontology.org/bao#BAO_0080015 percent neurite branch point http://www.bioassayontology.org/bao#BAO_0001103 percent activity http://www.bioassayontology.org/bao#BAO_0002742 EdU http://www.bioassayontology.org/bao#BAO_0002010 nucleotide http://www.bioassayontology.org/bao#BAO_0000931 BODIPY GTP http://www.bioassayontology.org/bao#BAO_0002010 nucleotide http://www.bioassayontology.org/bao#BAO_0002783 [35S]GTP-gamma S http://www.bioassayontology.org/bao#BAO_0002010 nucleotide http://www.bioassayontology.org/bao#BAO_0000775 Adenosine diphosphate http://www.bioassayontology.org/bao#BAO_0002010 nucleotide http://www.bioassayontology.org/bao#BAO_0002033 cell processing method http://www.bioassayontology.org/bao#BAO_0002011 processing method http://www.bioassayontology.org/bao#BAO_0002036 tissue processing method http://www.bioassayontology.org/bao#BAO_0002011 processing method http://www.bioassayontology.org/bao#BAO_0003025 phosphoprotein-specific antibody-coated bead based method http://www.bioassayontology.org/bao#BAO_0002013 phosphoprotein detection method http://www.bioassayontology.org/bao#BAO_0002151 RNA interference construct preparation method http://www.bioassayontology.org/bao#BAO_0002014 preparation method http://www.bioassayontology.org/bao#BAO_0002601 antibody preparation method http://www.bioassayontology.org/bao#BAO_0002014 preparation method http://www.bioassayontology.org/bao#BAO_0003029 small molecule preparation method http://www.bioassayontology.org/bao#BAO_0002014 preparation method http://www.bioassayontology.org/bao#BAO_0001007 Resorufin alpha-D-pyranoside http://www.bioassayontology.org/bao#BAO_0002015 carbohydrate http://www.bioassayontology.org/bao#BAO_0000782 D-galactose http://www.bioassayontology.org/bao#BAO_0002015 carbohydrate http://www.bioassayontology.org/bao#BAO_0000845 Alpha-D-glucose http://www.bioassayontology.org/bao#BAO_0002015 carbohydrate http://www.bioassayontology.org/bao#BAO_0000964 Mannose-6-phosphate http://www.bioassayontology.org/bao#BAO_0002015 carbohydrate http://www.bioassayontology.org/bao#BAO_0000925 Glucose-6-phosphate http://www.bioassayontology.org/bao#BAO_0002015 carbohydrate http://www.bioassayontology.org/bao#BAO_0000910 Fluorescein Di-beta-D-Glucopyranoside http://www.bioassayontology.org/bao#BAO_0002015 carbohydrate http://www.bioassayontology.org/bao#BAO_0000924 Glucose http://www.bioassayontology.org/bao#BAO_0002015 carbohydrate http://www.bioassayontology.org/bao#BAO_0000927 Glycogen http://www.bioassayontology.org/bao#BAO_0002015 carbohydrate http://www.bioassayontology.org/bao#BAO_0001008 Resorufin beta-D-glucopyranoside http://www.bioassayontology.org/bao#BAO_0002015 carbohydrate http://www.bioassayontology.org/bao#BAO_0000044 cytokine-specific antibody bead-based method http://www.bioassayontology.org/bao#BAO_0002017 cytokine quantitation method http://www.bioassayontology.org/bao#BAO_0002045 primary structure analysis method http://www.bioassayontology.org/bao#BAO_0002026 structure analysis method http://www.bioassayontology.org/bao#BAO_0002212 computational structure analysis http://www.bioassayontology.org/bao#BAO_0002095 bioinformatics method http://www.bioassayontology.org/bao#BAO_0002409 secondary structure analysis method http://www.bioassayontology.org/bao#BAO_0002026 structure analysis method http://www.bioassayontology.org/bao#BAO_0002410 structure activity relationship analysis http://www.bioassayontology.org/bao#BAO_0002026 structure analysis method http://www.bioassayontology.org/bao#BAO_0002035 cell fixation method http://www.bioassayontology.org/bao#BAO_0002033 cell processing method http://www.bioassayontology.org/bao#BAO_0002037 tissue fixation method http://www.bioassayontology.org/bao#BAO_0002036 tissue processing method http://www.bioassayontology.org/bao#BAO_0002630 native conformation http://www.bioassayontology.org/bao#BAO_0002038 conformation http://www.bioassayontology.org/bao#BAO_0002629 unfolded conformation http://www.bioassayontology.org/bao#BAO_0002038 conformation http://www.bioassayontology.org/bao#BAO_0002786 cell cycle state assay http://www.bioassayontology.org/bao#BAO_0002041 cell cycle assay http://www.bioassayontology.org/bao#BAO_0010002 2 color apoptosis assay http://www.bioassayontology.org/bao#BAO_0002043 apoptosis assay http://www.bioassayontology.org/bao#BAO_0010053 Fluorescence imaging apoptosis assay http://www.bioassayontology.org/bao#BAO_0002043 apoptosis assay http://www.bioassayontology.org/bao#BAO_0010003 3 color apoptosis assay http://www.bioassayontology.org/bao#BAO_0002043 apoptosis assay http://www.bioassayontology.org/bao#BAO_0002740 S phase assessment method http://www.bioassayontology.org/bao#BAO_0002047 cell cycle progression assessment method http://www.bioassayontology.org/bao#BAO_0002741 M phase assessment method http://www.bioassayontology.org/bao#BAO_0002047 cell cycle progression assessment method http://www.bioassayontology.org/bao#BAO_0002069 measured profile http://www.bioassayontology.org/bao#BAO_0002067 assay readout type http://www.bioassayontology.org/bao#BAO_0002200 fluorescence anisotropy readout http://www.bioassayontology.org/bao#BAO_0002068 calculated value http://www.bioassayontology.org/bao#BAO_0002201 fluorescence polarization readout http://www.bioassayontology.org/bao#BAO_0002068 calculated value http://www.bioassayontology.org/bao#BAO_0002071 time course profile http://www.bioassayontology.org/bao#BAO_0002069 measured profile http://www.bioassayontology.org/bao#BAO_0002769 concentration profile http://www.bioassayontology.org/bao#BAO_0002069 measured profile http://www.bioassayontology.org/bao#BAO_0002770 temperature profile http://www.bioassayontology.org/bao#BAO_0002069 measured profile http://www.bioassayontology.org/bao#BAO_0002078 purification from natural source http://www.bioassayontology.org/bao#BAO_0002076 extraction from natural source http://www.bioassayontology.org/bao#BAO_0003031 quantitative PCR http://www.bioassayontology.org/bao#BAO_0002080 polymerase chain reaction http://www.bioassayontology.org/bao#BAO_0001016 Sigma-Aldrich http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000946 IntelliCyt Corporation http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000831 AB SCIEX http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000721 MicroSource Discovery Systems http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000935 Hamamatsu http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0002729 AAT Bioquest http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000842 Agilent Technologies http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000798 Mirus Bio LLC http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000879 Cell Signaling http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000863 BMG Labtech http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000297 Perkin Elmer http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000303 Promega http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000305 Cambrex http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000306 Lonza http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000720 ChemBridge http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000729 LJL BioSystems http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000730 Analytical Luminescence Laboratory http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000731 Tecan http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000746 GE Healthcare http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000802 ChemDiv http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000832 ABD Bioquest http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000847 AnaSpec http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000851 Applied Biosystems http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000858 Bachem http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000859 BD Biosciences http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000861 Bio-Tek Instruments http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000872 Calbiochem http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000881 Cisbio http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000889 Dako http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000893 DiscoveRx http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000955 LI-COR Biosciences http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000966 Meso Scale Discovery http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000968 MicroCal http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000969 Molecular Devices http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000994 Photon Technology International http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0001055 Zeiss http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0002021 Luminex http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0002541 Pierce http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0002558 Aurora Biomed http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0002568 BellBrook Labs http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0002582 Corning http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0002652 Gilson http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0002653 Thermo Fisher Scientific http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0002654 Bruker http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0002721 Molecular Probes http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0002959 Amnis http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0002960 CompuCyte http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0002961 Cyntellect http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0002962 FLUXION http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0002963 Leica Microsystems http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0002964 Olympus http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0002965 TAP Biosystems http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0002966 TTP LabTech http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0002968 Life Technologies Corporation http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0003101 BioAssay Systems http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0002967 Yokogawa http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0000677 Invitrogen http://www.bioassayontology.org/bao#BAO_0002091 commercial company http://www.bioassayontology.org/bao#BAO_0002282 computer simulation method http://www.bioassayontology.org/bao#BAO_0002094 computational method http://www.bioassayontology.org/bao#BAO_0002317 quantum chemistry computational method http://www.bioassayontology.org/bao#BAO_0002094 computational method http://www.bioassayontology.org/bao#BAO_0002335 statistical method http://www.bioassayontology.org/bao#BAO_0002094 computational method http://www.bioassayontology.org/bao#BAO_0002347 systems biology method http://www.bioassayontology.org/bao#BAO_0002094 computational method http://www.bioassayontology.org/bao#BAO_0002166 computational expression analysis http://www.bioassayontology.org/bao#BAO_0002095 bioinformatics method http://www.bioassayontology.org/bao#BAO_0002101 adherent http://www.bioassayontology.org/bao#BAO_0002099 cell growth property http://www.bioassayontology.org/bao#BAO_0002104 suspension http://www.bioassayontology.org/bao#BAO_0002099 cell growth property http://www.bioassayontology.org/bao#BAO_0002107 mixed http://www.bioassayontology.org/bao#BAO_0002099 cell growth property http://www.bioassayontology.org/bao#BAO_0010060 MEMA cell growth assay http://www.bioassayontology.org/bao#BAO_0003009 cell viability assay http://www.bioassayontology.org/bao#BAO_0001259 residence time http://www.bioassayontology.org/bao#BAO_0002114 time endpoint http://www.bioassayontology.org/bao#BAO_0001260 T http://www.bioassayontology.org/bao#BAO_0002114 time endpoint http://www.bioassayontology.org/bao#BAO_0001241 ED http://www.bioassayontology.org/bao#BAO_0002116 dosage endpoint http://www.bioassayontology.org/bao#BAO_0001242 ED25 http://www.bioassayontology.org/bao#BAO_0002116 dosage endpoint http://www.bioassayontology.org/bao#BAO_0001243 ED30 http://www.bioassayontology.org/bao#BAO_0002116 dosage endpoint http://www.bioassayontology.org/bao#BAO_0001244 ED90 http://www.bioassayontology.org/bao#BAO_0002116 dosage endpoint http://www.bioassayontology.org/bao#BAO_0001245 LD10 http://www.bioassayontology.org/bao#BAO_0002116 dosage endpoint http://www.bioassayontology.org/bao#BAO_0001246 ID50 http://www.bioassayontology.org/bao#BAO_0002116 dosage endpoint http://www.bioassayontology.org/bao#BAO_0001247 MinED http://www.bioassayontology.org/bao#BAO_0002116 dosage endpoint http://www.bioassayontology.org/bao#BAO_0001248 MTD http://www.bioassayontology.org/bao#BAO_0002116 dosage endpoint http://www.bioassayontology.org/bao#BAO_0001249 TD50 http://www.bioassayontology.org/bao#BAO_0002116 dosage endpoint http://www.bioassayontology.org/bao#BAO_0001262 ED80 http://www.bioassayontology.org/bao#BAO_0002116 dosage endpoint http://www.bioassayontology.org/bao#BAO_0001257 efflux ratio http://www.bioassayontology.org/bao#BAO_0002128 physical property endpoint http://www.bioassayontology.org/bao#BAO_0002808 permeability http://www.bioassayontology.org/bao#BAO_0002128 physical property endpoint http://www.bioassayontology.org/bao#BAO_0002137 computational profile endpoint http://www.bioassayontology.org/bao#BAO_0002136 profile endpoint http://www.bioassayontology.org/bao#BAO_0002139 panel-assay profile endpoint http://www.bioassayontology.org/bao#BAO_0002136 profile endpoint http://www.bioassayontology.org/bao#BAO_0080027 protein level http://www.bioassayontology.org/bao#BAO_0002136 profile endpoint http://www.bioassayontology.org/bao#BAO_0080030 metabaloid profile http://www.bioassayontology.org/bao#BAO_0002136 profile endpoint http://www.bioassayontology.org/bao#BAO_0080031 Cell Painting Profile http://www.bioassayontology.org/bao#BAO_0002136 profile endpoint http://www.bioassayontology.org/bao#BAO_0002138 gene-expression profile endpoint http://www.bioassayontology.org/bao#BAO_0002136 profile endpoint http://www.bioassayontology.org/bao#BAO_0080032 epigenetic profile http://www.bioassayontology.org/bao#BAO_0002137 computational profile endpoint http://www.bioassayontology.org/bao#BAO_0001235 EC20 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint http://www.bioassayontology.org/bao#BAO_0001236 EC150 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint http://www.bioassayontology.org/bao#BAO_0001237 EC90 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint http://www.bioassayontology.org/bao#BAO_0001238 IC95 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint http://www.bioassayontology.org/bao#BAO_0001239 MIC80 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint http://www.bioassayontology.org/bao#BAO_0001240 MIC90 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint http://www.bioassayontology.org/bao#BAO_0001263 EC10 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint http://www.bioassayontology.org/bao#BAO_0001264 EC25 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint http://www.bioassayontology.org/bao#BAO_0001265 IC75 http://www.bioassayontology.org/bao#BAO_0002162 concentration response endpoint http://www.bioassayontology.org/bao#BAO_0002531 non-specific protein binding assay http://www.bioassayontology.org/bao#BAO_0002182 pharmacokinetic assay http://purl.obolibrary.org/obo/NCIT_C79364 Pharmacology: Primary Pharmacodynamics http://www.bioassayontology.org/bao#BAO_0002183 pharmacodynamic assay http://purl.obolibrary.org/obo/NCIT_C79365 Pharmacology: Secondary Pharmacodynamics http://www.bioassayontology.org/bao#BAO_0002183 pharmacodynamic assay http://purl.obolibrary.org/obo/NCIT_C79367 Pharmacology: Pharmacodynamic Drug Interactions http://www.bioassayontology.org/bao#BAO_0002183 pharmacodynamic assay http://www.bioassayontology.org/bao#BAO_0002520 HYPER flask http://www.bioassayontology.org/bao#BAO_0002192 tissue culture flask http://www.bioassayontology.org/bao#BAO_0002199 T-25 http://www.bioassayontology.org/bao#BAO_0002192 tissue culture flask http://www.bioassayontology.org/bao#BAO_0002506 T-75 http://www.bioassayontology.org/bao#BAO_0002192 tissue culture flask http://www.bioassayontology.org/bao#BAO_0002517 T-175 http://www.bioassayontology.org/bao#BAO_0002192 tissue culture flask http://www.bioassayontology.org/bao#BAO_0002521 triple flask http://www.bioassayontology.org/bao#BAO_0002192 tissue culture flask http://www.bioassayontology.org/bao#BAO_0002514 T-225 http://www.bioassayontology.org/bao#BAO_0002192 tissue culture flask http://www.bioassayontology.org/bao#BAO_0002632 protein modification method http://www.bioassayontology.org/bao#BAO_0002197 modification method http://www.bioassayontology.org/bao#BAO_0002635 RNA modification method http://www.bioassayontology.org/bao#BAO_0002197 modification method http://www.bioassayontology.org/bao#BAO_0002155 silencing RNA delivery method http://www.bioassayontology.org/bao#BAO_0002198 delivery method http://www.bioassayontology.org/bao#BAO_0002013 phosphoprotein detection method http://www.bioassayontology.org/bao#BAO_0002202 assay design method http://www.bioassayontology.org/bao#BAO_0002017 cytokine quantitation method http://www.bioassayontology.org/bao#BAO_0002202 assay design method http://www.bioassayontology.org/bao#BAO_0002047 cell cycle progression assessment method http://www.bioassayontology.org/bao#BAO_0002202 assay design method http://www.bioassayontology.org/bao#BAO_0003032 kinase competitive binding method http://www.bioassayontology.org/bao#BAO_0002202 assay design method http://www.bioassayontology.org/bao#BAO_0040029 epigenetic modification detection method http://www.bioassayontology.org/bao#BAO_0002202 assay design method http://www.bioassayontology.org/bao#BAO_0002210 phylogenetic analysis using parsimony http://www.bioassayontology.org/bao#BAO_0002206 computational phylogenetic analysis http://www.bioassayontology.org/bao#BAO_0002216 3D structure prediction http://www.bioassayontology.org/bao#BAO_0002212 computational structure analysis http://www.bioassayontology.org/bao#BAO_0002213 2D structure prediction http://www.bioassayontology.org/bao#BAO_0002212 computational structure analysis http://www.bioassayontology.org/bao#BAO_0002218 computational NMR structure solution http://www.bioassayontology.org/bao#BAO_0002217 computational structure solution http://www.bioassayontology.org/bao#BAO_0002219 computational X-ray structure solution http://www.bioassayontology.org/bao#BAO_0002217 computational structure solution http://www.bioassayontology.org/bao#BAO_0002220 computational electron microscopy structure solution http://www.bioassayontology.org/bao#BAO_0002217 computational structure solution http://www.bioassayontology.org/bao#BAO_0002223 SwissModel homology modeling http://www.bioassayontology.org/bao#BAO_0002221 homology modeling http://www.bioassayontology.org/bao#BAO_0002222 MODELLER homology modeling http://www.bioassayontology.org/bao#BAO_0002221 homology modeling http://www.bioassayontology.org/bao#BAO_0002227 global range molecular matching http://www.bioassayontology.org/bao#BAO_0002226 protein-protein docking http://www.bioassayontology.org/bao#BAO_0002230 matching molecular models obtained from theory http://www.bioassayontology.org/bao#BAO_0002228 structure alignment http://www.bioassayontology.org/bao#BAO_0002232 sequence alignment by method http://www.bioassayontology.org/bao#BAO_0002231 sequence alignment http://www.bioassayontology.org/bao#BAO_0002244 sequence alignment by type http://www.bioassayontology.org/bao#BAO_0002231 sequence alignment http://www.bioassayontology.org/bao#BAO_0002239 progressive system alignment http://www.bioassayontology.org/bao#BAO_0002232 sequence alignment by method http://www.bioassayontology.org/bao#BAO_0002241 ClustalW sequence alignment http://www.bioassayontology.org/bao#BAO_0002240 Clustal sequence alignment http://www.bioassayontology.org/bao#BAO_0002242 ClustalX sequence alignment http://www.bioassayontology.org/bao#BAO_0002240 Clustal sequence alignment http://www.bioassayontology.org/bao#BAO_0002255 database filtering http://www.bioassayontology.org/bao#BAO_0002248 cheminformatics method http://www.bioassayontology.org/bao#BAO_0002258 structure database search http://www.bioassayontology.org/bao#BAO_0002248 cheminformatics method http://www.bioassayontology.org/bao#BAO_0002269 structure generation http://www.bioassayontology.org/bao#BAO_0002248 cheminformatics method http://www.bioassayontology.org/bao#BAO_0002250 distance geometry conformational search http://www.bioassayontology.org/bao#BAO_0002249 conformational search http://www.bioassayontology.org/bao#BAO_0002251 random conformational search http://www.bioassayontology.org/bao#BAO_0002249 conformational search http://www.bioassayontology.org/bao#BAO_0002254 systematic conformational search http://www.bioassayontology.org/bao#BAO_0002249 conformational search http://www.bioassayontology.org/bao#BAO_0002252 cartesian conformational search http://www.bioassayontology.org/bao#BAO_0002251 random conformational search http://www.bioassayontology.org/bao#BAO_0002253 dihedral conformational search http://www.bioassayontology.org/bao#BAO_0002251 random conformational search http://www.bioassayontology.org/bao#BAO_0002259 exact match structure search http://www.bioassayontology.org/bao#BAO_0002258 structure database search http://www.bioassayontology.org/bao#BAO_0002260 structure similarity search http://www.bioassayontology.org/bao#BAO_0002258 structure database search http://www.bioassayontology.org/bao#BAO_0002268 substructure search http://www.bioassayontology.org/bao#BAO_0002258 structure database search http://www.bioassayontology.org/bao#BAO_0002264 3D structure similarity search http://www.bioassayontology.org/bao#BAO_0002371 scaffold hopping http://www.bioassayontology.org/bao#BAO_0002261 2D structure similarity search http://www.bioassayontology.org/bao#BAO_0002371 scaffold hopping http://www.bioassayontology.org/bao#BAO_0002266 rapid overlay of chemical structures http://www.bioassayontology.org/bao#BAO_0002265 shape fingerprint search http://www.bioassayontology.org/bao#BAO_0002270 data based structure generation http://www.bioassayontology.org/bao#BAO_0002269 structure generation http://www.bioassayontology.org/bao#BAO_0002278 fragment based structure generation http://www.bioassayontology.org/bao#BAO_0002269 structure generation http://www.bioassayontology.org/bao#BAO_0002280 rule based structure generation http://www.bioassayontology.org/bao#BAO_0002269 structure generation http://www.bioassayontology.org/bao#BAO_0002271 CORINA structure generation http://www.bioassayontology.org/bao#BAO_0002270 data based structure generation http://www.bioassayontology.org/bao#BAO_0002279 Chem-X structure generation http://www.bioassayontology.org/bao#BAO_0002278 fragment based structure generation http://www.bioassayontology.org/bao#BAO_0002281 CONCORD structure generation http://www.bioassayontology.org/bao#BAO_0002280 rule based structure generation http://www.bioassayontology.org/bao#BAO_0002296 local minimum search http://www.bioassayontology.org/bao#BAO_0002282 computer simulation method http://www.bioassayontology.org/bao#BAO_0002303 stochastic simulation http://www.bioassayontology.org/bao#BAO_0002282 computer simulation method http://www.bioassayontology.org/bao#BAO_0002293 global minimum search http://www.bioassayontology.org/bao#BAO_0002282 computer simulation method http://www.bioassayontology.org/bao#BAO_0002284 classical force field simulation http://www.bioassayontology.org/bao#BAO_0002283 computer simulation method by force field http://www.bioassayontology.org/bao#BAO_0002288 polarizable force field simulation http://www.bioassayontology.org/bao#BAO_0002283 computer simulation method by force field http://www.bioassayontology.org/bao#BAO_0002289 second generation force field simulation http://www.bioassayontology.org/bao#BAO_0002283 computer simulation method by force field http://www.bioassayontology.org/bao#BAO_0002287 GROMOS force field simulation http://www.bioassayontology.org/bao#BAO_0002284 classical force field simulation http://www.bioassayontology.org/bao#BAO_0002285 AMBER force field simulation http://www.bioassayontology.org/bao#BAO_0002284 classical force field simulation http://www.bioassayontology.org/bao#BAO_0002399 AMBER polarizable http://www.bioassayontology.org/bao#BAO_0002288 polarizable force field simulation http://www.bioassayontology.org/bao#BAO_0002400 CHARMM polarizable http://www.bioassayontology.org/bao#BAO_0002288 polarizable force field simulation http://www.bioassayontology.org/bao#BAO_0002292 MMFF force field simulation http://www.bioassayontology.org/bao#BAO_0002289 second generation force field simulation http://www.bioassayontology.org/bao#BAO_0002290 CFF force field simulation http://www.bioassayontology.org/bao#BAO_0002289 second generation force field simulation http://www.bioassayontology.org/bao#BAO_0002291 MM4 force field simulation http://www.bioassayontology.org/bao#BAO_0002289 second generation force field simulation http://www.bioassayontology.org/bao#BAO_0002297 energy minimization method http://www.bioassayontology.org/bao#BAO_0002296 local minimum search http://www.bioassayontology.org/bao#BAO_0002298 Newton-Raphson method http://www.bioassayontology.org/bao#BAO_0002297 energy minimization method http://www.bioassayontology.org/bao#BAO_0002299 conjugate gradient method http://www.bioassayontology.org/bao#BAO_0002297 energy minimization method http://www.bioassayontology.org/bao#BAO_0002300 steepest descent method http://www.bioassayontology.org/bao#BAO_0002297 energy minimization method http://www.bioassayontology.org/bao#BAO_0002302 constraint molecular dynamics simulation http://www.bioassayontology.org/bao#BAO_0002301 molecular dynamics simulation http://www.bioassayontology.org/bao#BAO_0002304 Monte Carlo simulation http://www.bioassayontology.org/bao#BAO_0002303 stochastic simulation http://www.bioassayontology.org/bao#BAO_0002307 partial least squares QSAR http://www.bioassayontology.org/bao#BAO_0002306 linear QSAR http://www.bioassayontology.org/bao#BAO_0002308 regression QSAR http://www.bioassayontology.org/bao#BAO_0002306 linear QSAR http://www.bioassayontology.org/bao#BAO_0002310 neural network QSAR http://www.bioassayontology.org/bao#BAO_0002309 non-linear QSAR http://www.bioassayontology.org/bao#BAO_0002311 recursive partitioning QSAR http://www.bioassayontology.org/bao#BAO_0002309 non-linear QSAR http://www.bioassayontology.org/bao#BAO_0002314 comparative molecular similarity indices analysis http://www.bioassayontology.org/bao#BAO_0002312 three dimensional QSAR http://www.bioassayontology.org/bao#BAO_0002315 self organizing molecular field analysis http://www.bioassayontology.org/bao#BAO_0002312 three dimensional QSAR http://www.bioassayontology.org/bao#BAO_0002319 Hartree-Fock method http://www.bioassayontology.org/bao#BAO_0002318 ab initio quantum chemistry computational method http://www.bioassayontology.org/bao#BAO_0002322 post Hartree-Fock method http://www.bioassayontology.org/bao#BAO_0002318 ab initio quantum chemistry computational method http://www.bioassayontology.org/bao#BAO_0002320 restricted open-shell Hartree-Fock http://www.bioassayontology.org/bao#BAO_0002319 Hartree-Fock method http://www.bioassayontology.org/bao#BAO_0002321 unrestricted Hartree-Fock http://www.bioassayontology.org/bao#BAO_0002319 Hartree-Fock method http://www.bioassayontology.org/bao#BAO_0002323 configuration interaction method http://www.bioassayontology.org/bao#BAO_0002322 post Hartree-Fock method http://www.bioassayontology.org/bao#BAO_0002324 coupled cluster method http://www.bioassayontology.org/bao#BAO_0002322 post Hartree-Fock method http://www.bioassayontology.org/bao#BAO_0002325 quadratic configuration interaction method http://www.bioassayontology.org/bao#BAO_0002322 post Hartree-Fock method http://www.bioassayontology.org/bao#BAO_0002327 pi-electron computational method http://www.bioassayontology.org/bao#BAO_0002326 semi-empirical quantum chemistry computational method http://www.bioassayontology.org/bao#BAO_0002329 valence electron computational method http://www.bioassayontology.org/bao#BAO_0002326 semi-empirical quantum chemistry computational method http://www.bioassayontology.org/bao#BAO_0002328 Pariser Parr Pople method http://www.bioassayontology.org/bao#BAO_0002327 pi-electron computational method http://www.bioassayontology.org/bao#BAO_0002330 Zerner's intermediate neglect of differential overlap http://www.bioassayontology.org/bao#BAO_0002329 valence electron computational method http://www.bioassayontology.org/bao#BAO_0002331 austin model 1 http://www.bioassayontology.org/bao#BAO_0002329 valence electron computational method http://www.bioassayontology.org/bao#BAO_0002332 intermediate neglect of differential overlap http://www.bioassayontology.org/bao#BAO_0002329 valence electron computational method http://www.bioassayontology.org/bao#BAO_0002333 modified neglect of differential overlap http://www.bioassayontology.org/bao#BAO_0002329 valence electron computational method http://www.bioassayontology.org/bao#BAO_0002334 parameterized model number 3 http://www.bioassayontology.org/bao#BAO_0002329 valence electron computational method http://www.bioassayontology.org/bao#BAO_0002336 experimental design method http://www.bioassayontology.org/bao#BAO_0002335 statistical method http://www.bioassayontology.org/bao#BAO_0002341 statistical classification method http://www.bioassayontology.org/bao#BAO_0002335 statistical method http://www.bioassayontology.org/bao#BAO_0002337 completely randomized design http://www.bioassayontology.org/bao#BAO_0002336 experimental design method http://www.bioassayontology.org/bao#BAO_0002338 fractional factorial design http://www.bioassayontology.org/bao#BAO_0002336 experimental design method http://www.bioassayontology.org/bao#BAO_0002339 full factorial design http://www.bioassayontology.org/bao#BAO_0002336 experimental design method http://www.bioassayontology.org/bao#BAO_0002340 randomized block design http://www.bioassayontology.org/bao#BAO_0002336 experimental design method http://www.bioassayontology.org/bao#BAO_0002342 decision tree http://www.bioassayontology.org/bao#BAO_0002341 statistical classification method http://www.bioassayontology.org/bao#BAO_0002343 hierarchial clustering http://www.bioassayontology.org/bao#BAO_0002341 statistical classification method http://www.bioassayontology.org/bao#BAO_0002344 k means clustering http://www.bioassayontology.org/bao#BAO_0002341 statistical classification method http://www.bioassayontology.org/bao#BAO_0002345 neural network model http://www.bioassayontology.org/bao#BAO_0002341 statistical classification method http://www.bioassayontology.org/bao#BAO_0002346 principal component analysis http://www.bioassayontology.org/bao#BAO_0002341 statistical classification method http://www.bioassayontology.org/bao#BAO_0002348 pathway analysis http://www.bioassayontology.org/bao#BAO_0002347 systems biology method http://www.bioassayontology.org/bao#BAO_0002363 target family knowledge analysis http://www.bioassayontology.org/bao#BAO_0002347 systems biology method http://www.bioassayontology.org/bao#BAO_0002349 pathway analysis by knowledge base http://www.bioassayontology.org/bao#BAO_0002348 pathway analysis http://www.bioassayontology.org/bao#BAO_0002353 pathway analysis by method http://www.bioassayontology.org/bao#BAO_0002348 pathway analysis http://www.bioassayontology.org/bao#BAO_0002350 automatic pathway analysis http://www.bioassayontology.org/bao#BAO_0002349 pathway analysis by knowledge base http://www.bioassayontology.org/bao#BAO_0002351 natural language processing http://www.bioassayontology.org/bao#BAO_0002350 automatic pathway analysis http://www.bioassayontology.org/bao#BAO_0002354 gene list enrichment analysis http://www.bioassayontology.org/bao#BAO_0002353 pathway analysis by method http://www.bioassayontology.org/bao#BAO_0002359 integrated pathway analysis http://www.bioassayontology.org/bao#BAO_0002353 pathway analysis by method http://www.bioassayontology.org/bao#BAO_0002361 network analysis http://www.bioassayontology.org/bao#BAO_0002353 pathway analysis by method http://www.bioassayontology.org/bao#BAO_0002360 MetaDiscovery pathway analysis http://www.bioassayontology.org/bao#BAO_0002359 integrated pathway analysis http://www.bioassayontology.org/bao#BAO_0002362 Cytoscape network analysis http://www.bioassayontology.org/bao#BAO_0002361 network analysis http://www.bioassayontology.org/bao#BAO_0002365 ligand based virtual screening http://www.bioassayontology.org/bao#BAO_0002364 virtual screening http://www.bioassayontology.org/bao#BAO_0002372 structure based virtual screening http://www.bioassayontology.org/bao#BAO_0002364 virtual screening http://www.bioassayontology.org/bao#BAO_0002371 scaffold hopping http://www.bioassayontology.org/bao#BAO_0002365 ligand based virtual screening http://www.bioassayontology.org/bao#BAO_0002368 DISCOtech modeling http://www.bioassayontology.org/bao#BAO_0002366 ligand based pharmacophore model http://www.bioassayontology.org/bao#BAO_0002369 distance comparison modeling http://www.bioassayontology.org/bao#BAO_0002366 ligand based pharmacophore model http://www.bioassayontology.org/bao#BAO_0002370 genetic algorithm similary program http://www.bioassayontology.org/bao#BAO_0002366 ligand based pharmacophore model http://www.bioassayontology.org/bao#BAO_0002367 Catalyst modeling http://www.bioassayontology.org/bao#BAO_0002366 ligand based pharmacophore model http://www.bioassayontology.org/bao#BAO_0002374 molecular docking by method http://www.bioassayontology.org/bao#BAO_0002373 molecular docking http://www.bioassayontology.org/bao#BAO_0002393 molecular docking by scoring function http://www.bioassayontology.org/bao#BAO_0002373 molecular docking http://www.bioassayontology.org/bao#BAO_0002375 Monte Carlo minimization method http://www.bioassayontology.org/bao#BAO_0002374 molecular docking by method http://www.bioassayontology.org/bao#BAO_0002377 Monte Carlo simulated annealing http://www.bioassayontology.org/bao#BAO_0002374 molecular docking by method http://www.bioassayontology.org/bao#BAO_0002379 descriptor matching method http://www.bioassayontology.org/bao#BAO_0002374 molecular docking by method http://www.bioassayontology.org/bao#BAO_0002387 incremental construction method http://www.bioassayontology.org/bao#BAO_0002374 molecular docking by method http://www.bioassayontology.org/bao#BAO_0002391 tabu docking method http://www.bioassayontology.org/bao#BAO_0002374 molecular docking by method http://www.bioassayontology.org/bao#BAO_0002383 genetic algorithm method http://www.bioassayontology.org/bao#BAO_0002374 molecular docking by method http://www.bioassayontology.org/bao#BAO_0002376 internal coordinate mechanics method http://www.bioassayontology.org/bao#BAO_0002375 Monte Carlo minimization method http://www.bioassayontology.org/bao#BAO_0002378 AutoDock docking method http://www.bioassayontology.org/bao#BAO_0002377 Monte Carlo simulated annealing http://www.bioassayontology.org/bao#BAO_0002380 ADAM docking method http://www.bioassayontology.org/bao#BAO_0002379 descriptor matching method http://www.bioassayontology.org/bao#BAO_0002382 SLIDE docking method http://www.bioassayontology.org/bao#BAO_0002379 descriptor matching method http://www.bioassayontology.org/bao#BAO_0002381 DOCK docking method http://www.bioassayontology.org/bao#BAO_0002379 descriptor matching method http://www.bioassayontology.org/bao#BAO_0002389 FlexX docking method http://www.bioassayontology.org/bao#BAO_0002387 incremental construction method http://www.bioassayontology.org/bao#BAO_0002390 Hummerhead docking method http://www.bioassayontology.org/bao#BAO_0002387 incremental construction method http://www.bioassayontology.org/bao#BAO_0002388 DOCK4 docking method http://www.bioassayontology.org/bao#BAO_0002387 incremental construction method http://www.bioassayontology.org/bao#BAO_0002392 SFdock docking method http://www.bioassayontology.org/bao#BAO_0002391 tabu docking method http://www.bioassayontology.org/bao#BAO_0002394 empirical scoring function http://www.bioassayontology.org/bao#BAO_0002393 molecular docking by scoring function http://www.bioassayontology.org/bao#BAO_0002398 force field based scoring function http://www.bioassayontology.org/bao#BAO_0002393 molecular docking by scoring function http://www.bioassayontology.org/bao#BAO_0002402 knowledge based scoring function http://www.bioassayontology.org/bao#BAO_0002393 molecular docking by scoring function http://www.bioassayontology.org/bao#BAO_0002403 DrugScore scoring function http://www.bioassayontology.org/bao#BAO_0002402 knowledge based scoring function http://www.bioassayontology.org/bao#BAO_0002404 potentials of mean force scoring function http://www.bioassayontology.org/bao#BAO_0002402 knowledge based scoring function http://www.bioassayontology.org/bao#BAO_0002408 SPROUT pharmacophore search http://www.bioassayontology.org/bao#BAO_0002405 receptor based pharmacophore search http://www.bioassayontology.org/bao#BAO_0002406 CoMFA pharmacophore search http://www.bioassayontology.org/bao#BAO_0002405 receptor based pharmacophore search http://www.bioassayontology.org/bao#BAO_0002407 GRID pharmacophore search http://www.bioassayontology.org/bao#BAO_0002405 receptor based pharmacophore search http://www.bioassayontology.org/bao#BAO_0002412 SAR by NMR http://www.bioassayontology.org/bao#BAO_0002410 structure activity relationship analysis http://www.bioassayontology.org/bao#BAO_0002418 dilution method http://www.bioassayontology.org/bao#BAO_0002413 titration method http://www.bioassayontology.org/bao#BAO_0002431 gene expression modulation method http://www.bioassayontology.org/bao#BAO_0002429 assay supporting method http://www.bioassayontology.org/bao#BAO_0002011 processing method http://www.bioassayontology.org/bao#BAO_0002429 assay supporting method http://www.bioassayontology.org/bao#BAO_0002014 preparation method http://www.bioassayontology.org/bao#BAO_0002429 assay supporting method http://www.bioassayontology.org/bao#BAO_0002026 structure analysis method http://www.bioassayontology.org/bao#BAO_0002429 assay supporting method http://www.bioassayontology.org/bao#BAO_0002197 modification method http://www.bioassayontology.org/bao#BAO_0002429 assay supporting method http://www.bioassayontology.org/bao#BAO_0002198 delivery method http://www.bioassayontology.org/bao#BAO_0002429 assay supporting method http://www.bioassayontology.org/bao#BAO_0002413 titration method http://www.bioassayontology.org/bao#BAO_0002429 assay supporting method http://www.bioassayontology.org/bao#BAO_0002452 labeling method http://www.bioassayontology.org/bao#BAO_0002429 assay supporting method http://www.bioassayontology.org/bao#BAO_0002485 reconstitution method http://www.bioassayontology.org/bao#BAO_0002429 assay supporting method http://www.bioassayontology.org/bao#BAO_0002500 separation method http://www.bioassayontology.org/bao#BAO_0002429 assay supporting method http://www.bioassayontology.org/bao#BAO_0002647 cell culture method http://www.bioassayontology.org/bao#BAO_0002429 assay supporting method http://www.bioassayontology.org/bao#BAO_0002445 genotyping method http://www.bioassayontology.org/bao#BAO_0002429 assay supporting method http://www.bioassayontology.org/bao#BAO_0002478 isotope labeling method http://www.bioassayontology.org/bao#BAO_0002452 labeling method http://www.bioassayontology.org/bao#BAO_0002469 fluorescent labeling method http://www.bioassayontology.org/bao#BAO_0002452 labeling method http://www.bioassayontology.org/bao#BAO_0002453 colorimetric labeling method http://www.bioassayontology.org/bao#BAO_0002452 labeling method http://www.bioassayontology.org/bao#BAO_0002455 colorimetric cell staining method http://www.bioassayontology.org/bao#BAO_0002453 colorimetric labeling method http://www.bioassayontology.org/bao#BAO_0002462 colorimetric protein staining method http://www.bioassayontology.org/bao#BAO_0002453 colorimetric labeling method http://www.bioassayontology.org/bao#BAO_0002461 trypan blue cell staining http://www.bioassayontology.org/bao#BAO_0002481 dye exclusion method http://www.bioassayontology.org/bao#BAO_0002486 complementation method http://www.bioassayontology.org/bao#BAO_0002485 reconstitution method http://www.bioassayontology.org/bao#BAO_0002498 liposome reconstitution http://www.bioassayontology.org/bao#BAO_0002485 reconstitution method http://www.bioassayontology.org/bao#BAO_0002487 chemical complementation http://www.bioassayontology.org/bao#BAO_0002486 complementation method http://www.bioassayontology.org/bao#BAO_0002495 protein complementation http://www.bioassayontology.org/bao#BAO_0002486 complementation method http://www.bioassayontology.org/bao#BAO_0002488 genetic complementation http://www.bioassayontology.org/bao#BAO_0002486 complementation method http://www.bioassayontology.org/bao#BAO_0002496 enzyme complementation http://www.bioassayontology.org/bao#BAO_0002495 protein complementation http://www.bioassayontology.org/bao#BAO_0002497 enzyme fragment complementation http://www.bioassayontology.org/bao#BAO_0002496 enzyme complementation http://www.bioassayontology.org/bao#BAO_0002501 affinity selection http://www.bioassayontology.org/bao#BAO_0002500 separation method http://www.bioassayontology.org/bao#BAO_0002502 antibody-based separation method http://www.bioassayontology.org/bao#BAO_0002500 separation method http://www.bioassayontology.org/bao#BAO_0002509 cell separation method http://www.bioassayontology.org/bao#BAO_0002500 separation method http://www.bioassayontology.org/bao#BAO_0002507 immunomagnetic separation method http://www.bioassayontology.org/bao#BAO_0002502 antibody-based separation method http://www.bioassayontology.org/bao#BAO_0002518 near-infrared imaging http://www.bioassayontology.org/bao#BAO_0002516 infrared imaging http://www.bioassayontology.org/bao#BAO_0002519 mid-infrared imaging http://www.bioassayontology.org/bao#BAO_0002516 infrared imaging http://www.bioassayontology.org/bao#BAO_0002534 drug abuse assay http://www.bioassayontology.org/bao#BAO_0002533 safety pharmacology assay http://www.bioassayontology.org/bao#BAO_0170005 cellular state phenotype http://www.bioassayontology.org/bao#BAO_0002542 cell phenotype http://www.bioassayontology.org/bao#BAO_0000877 CBF-his/runx1-biotin protein complex http://www.bioassayontology.org/bao#BAO_0002554 protein complex http://www.bioassayontology.org/bao#BAO_0002594 ATP coupled enzyme activity measurement method http://www.bioassayontology.org/bao#BAO_0002593 substrate coupled enzyme activity measurement method http://www.bioassayontology.org/bao#BAO_0002595 luciferin coupled enzyme activity measurement method http://www.bioassayontology.org/bao#BAO_0002593 substrate coupled enzyme activity measurement method http://www.bioassayontology.org/bao#BAO_0002791 ADP coupled enzyme activity measurement method http://www.bioassayontology.org/bao#BAO_0002593 substrate coupled enzyme activity measurement method http://www.bioassayontology.org/bao#BAO_0002602 ammonium sulfate precipitation method http://www.bioassayontology.org/bao#BAO_0002601 antibody preparation method http://www.bioassayontology.org/bao#BAO_0002603 affinity purification method http://www.bioassayontology.org/bao#BAO_0002601 antibody preparation method http://www.bioassayontology.org/bao#BAO_0002604 protein G-based affinity purification method http://www.bioassayontology.org/bao#BAO_0002603 affinity purification method http://www.bioassayontology.org/bao#BAO_0002605 antigen-based affinity purification method http://www.bioassayontology.org/bao#BAO_0002603 affinity purification method http://www.bioassayontology.org/bao#BAO_0002606 protein A-based affinity purification method http://www.bioassayontology.org/bao#BAO_0002603 affinity purification method http://www.bioassayontology.org/bao#BAO_0002607 protein A/G-based affinity purification method http://www.bioassayontology.org/bao#BAO_0002603 affinity purification method http://www.bioassayontology.org/bao#BAO_0002608 protein L-based affinity purification method http://www.bioassayontology.org/bao#BAO_0002603 affinity purification method http://www.bioassayontology.org/bao#BAO_0002610 IgG http://www.bioassayontology.org/bao#BAO_0002609 antibody isotype http://www.bioassayontology.org/bao#BAO_0002613 IgD http://www.bioassayontology.org/bao#BAO_0002609 antibody isotype http://www.bioassayontology.org/bao#BAO_0002611 IgA http://www.bioassayontology.org/bao#BAO_0002609 antibody isotype http://www.bioassayontology.org/bao#BAO_0002612 IgM http://www.bioassayontology.org/bao#BAO_0002609 antibody isotype http://www.bioassayontology.org/bao#BAO_0002614 IgE http://www.bioassayontology.org/bao#BAO_0002609 antibody isotype http://www.bioassayontology.org/bao#BAO_0002619 categorical purity http://www.bioassayontology.org/bao#BAO_0002618 purity http://www.bioassayontology.org/bao#BAO_0003069 purified http://www.bioassayontology.org/bao#BAO_0002619 categorical purity http://www.bioassayontology.org/bao#BAO_0003070 extract http://www.bioassayontology.org/bao#BAO_0002619 categorical purity http://www.bioassayontology.org/bao#BAO_0003071 extract fraction http://www.bioassayontology.org/bao#BAO_0002619 categorical purity http://www.bioassayontology.org/bao#BAO_0002633 heat denaturation http://www.bioassayontology.org/bao#BAO_0002631 protein denaturation method http://www.bioassayontology.org/bao#BAO_0002634 chemical denaturation http://www.bioassayontology.org/bao#BAO_0002631 protein denaturation method http://www.bioassayontology.org/bao#BAO_0002631 protein denaturation method http://www.bioassayontology.org/bao#BAO_0002632 protein modification method http://www.bioassayontology.org/bao#BAO_0002165 silencing RNA modification method http://www.bioassayontology.org/bao#BAO_0002635 RNA modification method http://www.bioassayontology.org/bao#BAO_0002648 one cell type http://www.bioassayontology.org/bao#BAO_0002647 cell culture method http://www.bioassayontology.org/bao#BAO_0001104 percent activation normalization http://www.bioassayontology.org/bao#BAO_0002750 normalization based on control http://www.bioassayontology.org/bao#BAO_0002160 z-score normalization http://www.bioassayontology.org/bao#BAO_0002751 normalization without control http://www.bioassayontology.org/bao#BAO_0002159 b-score normalization http://www.bioassayontology.org/bao#BAO_0002751 normalization without control http://www.bioassayontology.org/bao#BAO_0002161 mad-score normalization http://www.bioassayontology.org/bao#BAO_0002751 normalization without control http://www.bioassayontology.org/bao#BAO_0003116 material entity http://www.bioassayontology.org/bao#BAO_0002753 assay method component http://www.bioassayontology.org/bao#BAO_0003118 instrument http://www.bioassayontology.org/bao#BAO_0002753 assay method component http://www.bioassayontology.org/bao#BAO_0003119 software http://www.bioassayontology.org/bao#BAO_0002753 assay method component http://www.bioassayontology.org/bao#BAO_0002140 activity threshold specification http://www.bioassayontology.org/bao#BAO_0002754 assay data processing method http://www.bioassayontology.org/bao#BAO_0002170 endpoint modifier http://www.bioassayontology.org/bao#BAO_0002754 assay data processing method http://www.bioassayontology.org/bao#BAO_0002584 mitotic cell cycle state assay http://www.bioassayontology.org/bao#BAO_0002786 cell cycle state assay http://www.bioassayontology.org/bao#BAO_0002585 meiotic cell cycle state assay http://www.bioassayontology.org/bao#BAO_0002786 cell cycle state assay http://www.bioassayontology.org/bao#BAO_0010004 mitosis/apoptosis assay http://www.bioassayontology.org/bao#BAO_0002786 cell cycle state assay http://www.bioassayontology.org/bao#BAO_0010055 Fluorescence imaging cell cycle state assay http://www.bioassayontology.org/bao#BAO_0002786 cell cycle state assay http://www.bioassayontology.org/bao#BAO_0002735 luciferase enzyme activity assay http://www.bioassayontology.org/bao#BAO_0002792 oxidoreductase activity assay http://www.bioassayontology.org/bao#BAO_0002736 cytochrome P450 enzyme activity assay http://www.bioassayontology.org/bao#BAO_0002792 oxidoreductase activity assay http://www.bioassayontology.org/bao#BAO_0010054 Fluorescence imaging cell count assay http://www.bioassayontology.org/bao#BAO_0002805 cell proliferation assay http://www.bioassayontology.org/bao#BAO_0002898 screening lab investigator http://www.bioassayontology.org/bao#BAO_0002900 researcher role http://www.bioassayontology.org/bao#BAO_0002899 screening principal investigator http://www.bioassayontology.org/bao#BAO_0002900 researcher role http://www.bioassayontology.org/bao#BAO_0002910 allosteric agonism http://www.bioassayontology.org/bao#BAO_0002902 agonism http://www.bioassayontology.org/bao#BAO_0002911 partial agonism http://www.bioassayontology.org/bao#BAO_0002902 agonism http://www.bioassayontology.org/bao#BAO_0002912 full agonism http://www.bioassayontology.org/bao#BAO_0002902 agonism http://www.bioassayontology.org/bao#BAO_0002913 inverse agonism http://www.bioassayontology.org/bao#BAO_0002902 agonism http://www.bioassayontology.org/bao#BAO_0003910 allosteric antagonism http://www.bioassayontology.org/bao#BAO_0002903 antagonism http://www.bioassayontology.org/bao#BAO_0002936 Hypercyt http://www.bioassayontology.org/bao#BAO_0002935 automated cytometer http://www.bioassayontology.org/bao#BAO_0002939 Acumen http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0002942 BD Pathway 855 http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0002938 3i Marianas http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0002943 BioFlux 1000 http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0150001 IN Cell Analyzer 3000 http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0002940 ArrayScan VTI HCS Reader http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0002941 BD Pathway 435 http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0002944 Celigo S Imaging Cell Cytometer http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0002945 Cell Voyager 1000 http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0002946 Cell Voyager 6000 http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0002947 Cell Voyager 7000 http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0002948 FlowSight http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0002949 iCyte Automated Imaging Cytometer http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0002952 ImageXpress Ultra http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0002953 ImageXpress Velos Laser Scanning Cytometer http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0002954 IN Cell Analyzer 2000 http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0002957 Operetta http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0002958 Tali Image Cytometer http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0150002 CellWoRx HCS Reader http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0150003 CellInsight NXT HCS Platform http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0150004 ArrayScan II HCS Reader http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0150005 ArrayScan 3.1 HCS Reader http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0150006 ArrayScan 4.0 HCS Reader http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0150075 iMIC platform/ Polychrome V imaging system, (TILL Photonics/ FEI Munic GmbH) http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0150082 IN Cell Analyzer 1000 http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0002956 Opera http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0150007 KineticScan HCS Reader http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0002955 IN Cell Analyzer 6000 http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0002951 ImageXpress Micro http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0002950 ImageStreamX Mark II Imaging Flow Cytometer http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0150000 IN Cell Analyzer 2200 http://www.bioassayontology.org/bao#BAO_0002937 imaging cytometer http://www.bioassayontology.org/bao#BAO_0002776 radioligand binding assay http://www.bioassayontology.org/bao#BAO_0002989 binding assay http://www.bioassayontology.org/bao#BAO_0002908 KiNativ assay http://www.bioassayontology.org/bao#BAO_0002989 binding assay http://www.bioassayontology.org/bao#BAO_0003011 KINOMEScan assay http://www.bioassayontology.org/bao#BAO_0002989 binding assay http://www.bioassayontology.org/bao#BAO_0002803 neurite outgrowth assay http://www.bioassayontology.org/bao#BAO_0002991 cell morphology assay http://www.bioassayontology.org/bao#BAO_0010057 Fluorescence imaging morphology assay http://www.bioassayontology.org/bao#BAO_0002991 cell morphology assay http://www.bioassayontology.org/bao#BAO_0010058 Fluorescence imaging multiplex cytological profiling assay http://www.bioassayontology.org/bao#BAO_0002991 cell morphology assay http://www.bioassayontology.org/bao#BAO_0002790 hydrolase activity assay http://www.bioassayontology.org/bao#BAO_0002994 enzyme activity assay http://www.bioassayontology.org/bao#BAO_0002794 isomerase activity assay http://www.bioassayontology.org/bao#BAO_0002994 enzyme activity assay http://www.bioassayontology.org/bao#BAO_0002792 oxidoreductase activity assay http://www.bioassayontology.org/bao#BAO_0002994 enzyme activity assay http://www.bioassayontology.org/bao#BAO_0002793 lyase activity assay http://www.bioassayontology.org/bao#BAO_0002994 enzyme activity assay http://www.bioassayontology.org/bao#BAO_0002795 transferase activity assay http://www.bioassayontology.org/bao#BAO_0002994 enzyme activity assay http://www.bioassayontology.org/bao#BAO_0002190 mitochondrial membrane potential assay http://www.bioassayontology.org/bao#BAO_0002996 membrane potential assay http://www.bioassayontology.org/bao#BAO_0002194 plasma membrane potential assay http://www.bioassayontology.org/bao#BAO_0002996 membrane potential assay http://www.bioassayontology.org/bao#BAO_0002195 nuclear membrane potential assay http://www.bioassayontology.org/bao#BAO_0002996 membrane potential assay http://www.bioassayontology.org/bao#BAO_0002763 platelet activation assay http://www.bioassayontology.org/bao#BAO_0003002 signal transduction assay http://www.bioassayontology.org/bao#BAO_0010005 single cell protein secretion microfluidic assay http://www.bioassayontology.org/bao#BAO_0003003 cytokine secretion assay http://www.bioassayontology.org/bao#BAO_0010051 ELISA protein secretion profiling assay http://www.bioassayontology.org/bao#BAO_0003003 cytokine secretion assay http://www.bioassayontology.org/bao#BAO_0010050 Bead-based immunoassay for protein state http://www.bioassayontology.org/bao#BAO_0003005 phosphorylation assay http://www.bioassayontology.org/bao#BAO_0010052 ELISA protein state assay http://www.bioassayontology.org/bao#BAO_0010026 protein profiling assay http://www.bioassayontology.org/bao#BAO_0010059 Fluorescence imaging protein state assay http://www.bioassayontology.org/bao#BAO_0003005 phosphorylation assay http://www.bioassayontology.org/bao#BAO_0003012 fluorescent protein reporter gene assay http://www.bioassayontology.org/bao#BAO_0003006 reporter gene assay http://www.bioassayontology.org/bao#BAO_0002661 luciferase reporter gene assay http://www.bioassayontology.org/bao#BAO_0003006 reporter gene assay http://www.bioassayontology.org/bao#BAO_0003013 beta galactosidase reporter gene assay http://www.bioassayontology.org/bao#BAO_0003006 reporter gene assay http://www.bioassayontology.org/bao#BAO_0003014 beta lactamase reporter gene assay http://www.bioassayontology.org/bao#BAO_0003006 reporter gene assay http://www.bioassayontology.org/bao#BAO_0003015 chloramphenicol acetyltransferase reporter gene assay http://www.bioassayontology.org/bao#BAO_0003006 reporter gene assay http://www.bioassayontology.org/bao#BAO_0010001 cell viability ATP quantitation assay http://www.bioassayontology.org/bao#BAO_0003009 cell viability assay http://www.bioassayontology.org/bao#BAO_0010056 Fluorescence imaging cell growth inhibition assay http://www.bioassayontology.org/bao#BAO_0003009 cell viability assay http://www.bioassayontology.org/bao#BAO_0003017 transcription factor binding site http://www.bioassayontology.org/bao#BAO_0003016 binding site http://www.bioassayontology.org/bao#BAO_0003030 kinase active-site binding method http://www.bioassayontology.org/bao#BAO_0003032 kinase competitive binding method http://www.bioassayontology.org/bao#BAO_0002022 dna-coated bead based method http://www.bioassayontology.org/bao#BAO_0003034 nucleic acid identification and quantitation method http://www.bioassayontology.org/bao#BAO_0002447 nucleic acid sequencing method http://www.bioassayontology.org/bao#BAO_0003034 nucleic acid identification and quantitation method http://www.bioassayontology.org/bao#BAO_0000914 fluorophosphonate-rhodamine http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000926 glutamate http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000980 O-methyl-fluorescein phosphate http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000827 6,8-difluoro-7-hydroxy-4-methylcoumarin http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0001054 zaprinast http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000826 6,8-difluoro-4-methylumbelliferyl phosphate http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0001044 vasopressin http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000830 A23187 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000825 5-carboxamidotryptamine http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000823 3-O-methylfluorescein phosphate http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000846 7-amino-4-methylcoumarin http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000797 quinidine http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000736 1-aminoanthracene http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000822 3-O-methyl-fluorescein http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0002672 fluo-8 calcium indicator http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000907 fluo-4 AM calcium indicator http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000915 fluozin-2 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000949 IPEGAL http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0001024 SYPRO orange dye http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000172 ACTOne Membrane Potential Dye http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000824 4 methylumbelliferyl-D-pyranoside http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000950 isoproterenol http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000840 7-amino-4-trifluoromethylcoumarin http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0002581 5/6 TAMRA http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000916 fluozin http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000820 1, 4 methyllumbelliferone http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000011 nucleic acid http://www.bioassayontology.org/bao#BAO_0003111 biological macromolecule http://www.bioassayontology.org/bao#BAO_0000021 LysoTracker Red http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000047 Syto 60 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000076 screened entity http://www.bioassayontology.org/bao#BAO_0003120 assay screened entity component http://www.bioassayontology.org/bao#BAO_0000116 Hoechst http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000639 doxorubicin http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000696 phosphate buffer http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000747 saponin http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000748 tetracycline http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000749 NADPH http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000754 S-adenosyl methionine http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000755 coenzyme Q http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000759 doxycycline http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000760 estrogen http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000763 ionomycin http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000765 NHK 477 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000769 retinoic acid http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000773 tunicamycin http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000778 creatine phosphate http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000781 deoxyluciferin http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000784 ethylene glycol ester of luciferin 6' methyl ether http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000786 luciferin 6-ME http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000787 luciferin-PPXE http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000788 luciferin-BE http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000789 peptide-aminoluciferin http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000795 furafylline http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000796 ketoconazole http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000799 lipofectin http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000800 TransIT-CHO kit http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000801 TransIT-LT1 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000811 wee1-like protein-luciferin 4-monooxygenase http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000829 [3H]N-methylscopolamine http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000838 acetylcholine http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000844 alkaline phosphatase-cAMP http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000848 angiotensin II http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000853 arachidonic acid http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000854 arrestin-GFP http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000860 beta-hydroxybutyryl coenzyme A http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000867 Brij-35 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000870 BTC AM Fluorescent Dye Indicator http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000874 calcium http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000876 carbachol http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000880 CHAPS http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000882 coenzyme A http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000883 Cy5 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000890 DAMGO http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000892 diphosphomevalonate http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000894 dopamine http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000897 dynorphin A http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000900 estrogen-alexa 633 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000945 indo-1 calcium indicator http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000960 luciferin-H http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000961 luciferin-H EGE http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000962 lysophosphatidylinositol http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000967 mevalonate http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000978 NP-40 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000986 para-nitrophenol http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000990 phosphoenolpyruvate http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000991 phosphoethanolamine http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000992 phosphomevalonate http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000995 pluronic F-127 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000996 phorbol myristate acetate http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000997 potassium phosphoenolpyruvate http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000999 profluorescent 1-AMA http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0001000 prostaglandin http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0001001 prostaglandin E2 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0001006 resorufin http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0001009 rhodamine http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0001010 rhodamine-conjugated sulfonate ester http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0001026 texas Red http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0001028 thallium http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0001030 thapsigargin http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0001037 triton X-100 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0001038 tween 20 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0002010 nucleotide http://www.bioassayontology.org/bao#BAO_0003111 biological macromolecule http://www.bioassayontology.org/bao#BAO_0002015 carbohydrate http://www.bioassayontology.org/bao#BAO_0003111 biological macromolecule http://www.bioassayontology.org/bao#BAO_0002149 RNA interference construct http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0002547 GST tag http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0002579 XTT red http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0002580 malachite green http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0002641 cyclin B1-luciferin 4-monooxygenase http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0002784 phosphatidylinositol (3,4,5)-triphosphate http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0003054 tricine http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0003108 beetle luciferin http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0100013 GPCR arrestin complex http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0100014 GPCR complex http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0003051 TO-PRO3 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000901 Eu3+-cAMP http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000695 MOPS http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0002651 FuGENE 6 http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0000638 forskolin http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0002933 experimental specification http://www.bioassayontology.org/bao#BAO_0003112 assay bioassay component http://www.bioassayontology.org/bao#BAO_0020005 experimental setting http://www.bioassayontology.org/bao#BAO_0003113 assay format component http://www.bioassayontology.org/bao#BAO_0003043 molecular entity http://www.bioassayontology.org/bao#BAO_0003116 material entity http://www.bioassayontology.org/bao#BAO_0000025 bead http://www.bioassayontology.org/bao#BAO_0003116 material entity http://www.bioassayontology.org/bao#BAO_0003075 molecular function http://www.bioassayontology.org/bao#BAO_0003117 function http://www.bioassayontology.org/bao#BAO_0150029 light source http://www.bioassayontology.org/bao#BAO_0003118 instrument http://www.bioassayontology.org/bao#BAO_0150100 Spectramax L http://www.bioassayontology.org/bao#BAO_0003118 instrument http://www.bioassayontology.org/bao#BAO_0150101 PHERAstar FSX http://www.bioassayontology.org/bao#BAO_0003118 instrument http://www.bioassayontology.org/bao#BAO_0150016 objective lens http://www.bioassayontology.org/bao#BAO_0003118 instrument http://www.bioassayontology.org/bao#BAO_0150021 image acquisition device http://www.bioassayontology.org/bao#BAO_0003118 instrument http://www.bioassayontology.org/bao#BAO_0180004 image analysis software http://www.bioassayontology.org/bao#BAO_0003119 software http://www.bioassayontology.org/bao#BAO_0180018 sequencing data alignment software http://www.bioassayontology.org/bao#BAO_0003119 software http://www.bioassayontology.org/bao#BAO_0180022 sequencing data analysis software http://www.bioassayontology.org/bao#BAO_0003119 software http://www.bioassayontology.org/bao#BAO_0010017 15 cm dish http://www.bioassayontology.org/bao#BAO_0010016 dish http://www.bioassayontology.org/bao#BAO_0010049 Microwestern http://www.bioassayontology.org/bao#BAO_0010026 protein profiling assay http://www.bioassayontology.org/bao#BAO_0010070 Tandem Mass Tag (TMT) MS Protein Quantification http://www.bioassayontology.org/bao#BAO_0010026 protein profiling assay http://www.bioassayontology.org/bao#BAO_0010071 Liquid Chromatography/Mass Spectroscopy (LC/MS) protein quantification http://www.bioassayontology.org/bao#BAO_0010026 protein profiling assay http://www.bioassayontology.org/bao#BAO_0010061 MS protein quantification assay http://www.bioassayontology.org/bao#BAO_0010027 shotgun MS protein profiling assay http://www.bioassayontology.org/bao#BAO_0010062 MS protein state assay http://www.bioassayontology.org/bao#BAO_0010027 shotgun MS protein profiling assay http://www.bioassayontology.org/bao#BAO_0010066 SWATH-MS protein quantification assay http://www.bioassayontology.org/bao#BAO_0010028 SWATH MS protein profiling assay http://www.bioassayontology.org/bao#BAO_0010063 P100 phosphoprotein quantification assay http://www.bioassayontology.org/bao#BAO_0010029 P100 protein profiling assay http://www.bioassayontology.org/bao#BAO_0010065 RPPA protein state assay http://www.bioassayontology.org/bao#BAO_0010030 RPPA protein profiling assay http://www.bioassayontology.org/bao#BAO_0010041 targeted metabolomic assay http://www.bioassayontology.org/bao#BAO_0010040 metabolomic assay http://www.bioassayontology.org/bao#BAO_0010076 low throughput screening http://www.bioassayontology.org/bao#BAO_0010072 parallel artificial membrane permeability assay http://www.bioassayontology.org/bao#BAO_0010074 high throughput screening http://www.bioassayontology.org/bao#BAO_0010073 assay screening throughput http://www.bioassayontology.org/bao#BAO_0010075 medium throughput screening http://www.bioassayontology.org/bao#BAO_0010073 assay screening throughput http://www.bioassayontology.org/bao#BAO_0020006 ex vivo http://www.bioassayontology.org/bao#BAO_0020005 experimental setting http://www.bioassayontology.org/bao#BAO_0020007 in silico http://www.bioassayontology.org/bao#BAO_0020005 experimental setting http://www.bioassayontology.org/bao#BAO_0020008 in vitro http://www.bioassayontology.org/bao#BAO_0020005 experimental setting http://www.bioassayontology.org/bao#BAO_0020009 in vivo http://www.bioassayontology.org/bao#BAO_0020005 experimental setting http://www.bioassayontology.org/bao#BAO_0040002 image correction http://www.bioassayontology.org/bao#BAO_0040001 image analysis method http://www.bioassayontology.org/bao#BAO_0040007 image segmentation http://www.bioassayontology.org/bao#BAO_0040001 image analysis method http://www.bioassayontology.org/bao#BAO_0040014 protein abundance method http://www.bioassayontology.org/bao#BAO_0040011 molecular abundance method http://www.bioassayontology.org/bao#BAO_0080005 neurite blebbing http://www.bioassayontology.org/bao#BAO_0080004 phenotypic mode of action http://www.bioassayontology.org/bao#BAO_0080006 neurite branching http://www.bioassayontology.org/bao#BAO_0080004 phenotypic mode of action http://www.bioassayontology.org/bao#BAO_0080008 neurite shortening http://www.bioassayontology.org/bao#BAO_0080004 phenotypic mode of action http://www.bioassayontology.org/bao#BAO_0080009 axon bundle defasciculation http://www.bioassayontology.org/bao#BAO_0080004 phenotypic mode of action http://www.bioassayontology.org/bao#BAO_0080010 axon fasciculation http://www.bioassayontology.org/bao#BAO_0080004 phenotypic mode of action http://www.bioassayontology.org/bao#BAO_0080012 NF-KappaB p65 translocation http://www.bioassayontology.org/bao#BAO_0080004 phenotypic mode of action http://www.bioassayontology.org/bao#BAO_0080020 cm/sec http://www.bioassayontology.org/bao#BAO_0080019 rate http://www.bioassayontology.org/bao#BAO_0080021 nmol/sec http://www.bioassayontology.org/bao#BAO_0080019 rate http://www.bioassayontology.org/bao#BAO_0000682 CellTiter-Glo Luminescent Cell Viability Assay http://www.bioassayontology.org/bao#BAO_0140017 Luciferase-based ('Glo') Assay System (Promega) http://www.bioassayontology.org/bao#BAO_0000298 Steady-Glo Luciferase Assay System http://www.bioassayontology.org/bao#BAO_0140017 Luciferase-based ('Glo') Assay System (Promega) http://www.bioassayontology.org/bao#BAO_0000299 Proteasome-Glo Chymotrypsin-Like Assay http://www.bioassayontology.org/bao#BAO_0140017 Luciferase-based ('Glo') Assay System (Promega) http://www.bioassayontology.org/bao#BAO_0000311 P450-Glo CYP2D6 Screening System http://www.bioassayontology.org/bao#BAO_0140017 Luciferase-based ('Glo') Assay System (Promega) http://www.bioassayontology.org/bao#BAO_0000333 P450-Glo CYP2C9 Screening System http://www.bioassayontology.org/bao#BAO_0140017 Luciferase-based ('Glo') Assay System (Promega) http://www.bioassayontology.org/bao#BAO_0000670 P450-Glo CYP2C19 Screening System http://www.bioassayontology.org/bao#BAO_0140017 Luciferase-based ('Glo') Assay System (Promega) http://www.bioassayontology.org/bao#BAO_0000674 P450-Glo CYP1A2 Screening System http://www.bioassayontology.org/bao#BAO_0140017 Luciferase-based ('Glo') Assay System (Promega) http://www.bioassayontology.org/bao#BAO_0000675 ONE-Glo Luciferase Assay System http://www.bioassayontology.org/bao#BAO_0140017 Luciferase-based ('Glo') Assay System (Promega) http://www.bioassayontology.org/bao#BAO_0000678 Kinase-Glo Plus Luminescent Kinase Assay http://www.bioassayontology.org/bao#BAO_0140017 Luciferase-based ('Glo') Assay System (Promega) http://www.bioassayontology.org/bao#BAO_0000679 Kinase-Glo Luminescent Kinase Assay http://www.bioassayontology.org/bao#BAO_0140017 Luciferase-based ('Glo') Assay System (Promega) http://www.bioassayontology.org/bao#BAO_0000681 Chroma-Glo Luciferase Assay System http://www.bioassayontology.org/bao#BAO_0140017 Luciferase-based ('Glo') Assay System (Promega) http://www.bioassayontology.org/bao#BAO_0000683 Caspase Glo 3/7 Assay http://www.bioassayontology.org/bao#BAO_0140017 Luciferase-based ('Glo') Assay System (Promega) http://www.bioassayontology.org/bao#BAO_0000685 Bright-Glo Luciferase Assay System http://www.bioassayontology.org/bao#BAO_0140017 Luciferase-based ('Glo') Assay System (Promega) http://www.bioassayontology.org/bao#BAO_0000687 Beta-Glo Assay System http://www.bioassayontology.org/bao#BAO_0140017 Luciferase-based ('Glo') Assay System (Promega) http://www.bioassayontology.org/bao#BAO_0000688 BacTiter-Glo Microbial Cell Viability Assay http://www.bioassayontology.org/bao#BAO_0140017 Luciferase-based ('Glo') Assay System (Promega) http://www.bioassayontology.org/bao#BAO_0000690 ADP Glo Kinase Assay http://www.bioassayontology.org/bao#BAO_0140017 Luciferase-based ('Glo') Assay System (Promega) http://www.bioassayontology.org/bao#BAO_0000680 Dual-Luciferase Reporter Assay System http://www.bioassayontology.org/bao#BAO_0140017 Luciferase-based ('Glo') Assay System (Promega) http://www.bioassayontology.org/bao#BAO_0000310 P450-Glo CYP3A4 Screening System http://www.bioassayontology.org/bao#BAO_0140017 Luciferase-based ('Glo') Assay System (Promega) http://www.bioassayontology.org/bao#BAO_0150009 optical microscope http://www.bioassayontology.org/bao#BAO_0150008 microscope http://www.bioassayontology.org/bao#BAO_0150010 confocal microscope http://www.bioassayontology.org/bao#BAO_0150008 microscope http://www.bioassayontology.org/bao#BAO_0150013 laser capture microdissection microscope http://www.bioassayontology.org/bao#BAO_0150009 optical microscope http://www.bioassayontology.org/bao#BAO_0150014 scanning force microscope http://www.bioassayontology.org/bao#BAO_0150009 optical microscope http://www.bioassayontology.org/bao#BAO_0150015 wide-field microscope http://www.bioassayontology.org/bao#BAO_0150009 optical microscope http://www.bioassayontology.org/bao#BAO_0150011 laser scanning confocal microscope http://www.bioassayontology.org/bao#BAO_0150010 confocal microscope http://www.bioassayontology.org/bao#BAO_0150012 spinning-disk confocal microscope http://www.bioassayontology.org/bao#BAO_0150010 confocal microscope http://www.bioassayontology.org/bao#BAO_0150025 electron multiplying charge coupled device http://www.bioassayontology.org/bao#BAO_0150022 area detector http://www.bioassayontology.org/bao#BAO_0150023 charge coupled device http://www.bioassayontology.org/bao#BAO_0150022 area detector http://www.bioassayontology.org/bao#BAO_0150024 complementary metal oxide semiconductor http://www.bioassayontology.org/bao#BAO_0150022 area detector http://www.bioassayontology.org/bao#BAO_0150027 photodiode http://www.bioassayontology.org/bao#BAO_0150026 spot detector http://www.bioassayontology.org/bao#BAO_0150028 photomultiplier tube http://www.bioassayontology.org/bao#BAO_0150026 spot detector http://www.bioassayontology.org/bao#BAO_0150030 arc lamp http://www.bioassayontology.org/bao#BAO_0150029 light source http://www.bioassayontology.org/bao#BAO_0150033 laser http://www.bioassayontology.org/bao#BAO_0150029 light source http://www.bioassayontology.org/bao#BAO_0150049 light-emitting diode http://www.bioassayontology.org/bao#BAO_0150029 light source http://www.bioassayontology.org/bao#BAO_0150050 tungsten halogen lamp http://www.bioassayontology.org/bao#BAO_0150029 light source http://www.bioassayontology.org/bao#BAO_0150031 mercury-vapor lamp http://www.bioassayontology.org/bao#BAO_0150030 arc lamp http://www.bioassayontology.org/bao#BAO_0150032 xenon lamp http://www.bioassayontology.org/bao#BAO_0150030 arc lamp http://www.bioassayontology.org/bao#BAO_0150034 diode laser http://www.bioassayontology.org/bao#BAO_0150033 laser http://www.bioassayontology.org/bao#BAO_0150035 dye laser http://www.bioassayontology.org/bao#BAO_0150033 laser http://www.bioassayontology.org/bao#BAO_0150045 solid state laser http://www.bioassayontology.org/bao#BAO_0150033 laser http://www.bioassayontology.org/bao#BAO_0150036 gas laser http://www.bioassayontology.org/bao#BAO_0150033 laser http://www.bioassayontology.org/bao#BAO_0150038 argon-ion laser http://www.bioassayontology.org/bao#BAO_0150037 ion laser http://www.bioassayontology.org/bao#BAO_0150039 helium-neon laser http://www.bioassayontology.org/bao#BAO_0150037 ion laser http://www.bioassayontology.org/bao#BAO_0150040 krypton-ion laser http://www.bioassayontology.org/bao#BAO_0150037 ion laser http://www.bioassayontology.org/bao#BAO_0150041 mixed argon-krypton gas laser http://www.bioassayontology.org/bao#BAO_0150037 ion laser http://www.bioassayontology.org/bao#BAO_0150043 helium-cadmium laser http://www.bioassayontology.org/bao#BAO_0150042 metal vapor laser http://www.bioassayontology.org/bao#BAO_0150046 chromium-doped lithium strontium aluminum fluoride laser http://www.bioassayontology.org/bao#BAO_0150045 solid state laser http://www.bioassayontology.org/bao#BAO_0150047 neodymium-yttrium aluminum garnet laser http://www.bioassayontology.org/bao#BAO_0150045 solid state laser http://www.bioassayontology.org/bao#BAO_0150048 titanium-doped sapphire laser http://www.bioassayontology.org/bao#BAO_0150045 solid state laser http://www.bioassayontology.org/bao#BAO_0165001 researcher http://www.bioassayontology.org/bao#BAO_0165000 people http://www.bioassayontology.org/bao#BAO_0170019 molecular localization phenotype http://www.bioassayontology.org/bao#BAO_0170001 molecular phenotype http://www.bioassayontology.org/bao#BAO_0170021 molecular expression phenotype http://www.bioassayontology.org/bao#BAO_0170001 molecular phenotype http://www.bioassayontology.org/bao#BAO_0170006 autophagic cell phenotype http://www.bioassayontology.org/bao#BAO_0170005 cellular state phenotype http://www.bioassayontology.org/bao#BAO_0170007 inflamed cell phenotype http://www.bioassayontology.org/bao#BAO_0170005 cellular state phenotype http://www.bioassayontology.org/bao#BAO_0170009 neuronal cell phenotype http://www.bioassayontology.org/bao#BAO_0170005 cellular state phenotype http://www.bioassayontology.org/bao#BAO_0170012 dead cell phenotype http://www.bioassayontology.org/bao#BAO_0170005 cellular state phenotype http://www.bioassayontology.org/bao#BAO_0170013 dying cell phenotype http://www.bioassayontology.org/bao#BAO_0170005 cellular state phenotype http://www.bioassayontology.org/bao#BAO_0170016 cell cycle phase phenotype http://www.bioassayontology.org/bao#BAO_0170005 cellular state phenotype http://www.bioassayontology.org/bao#BAO_0170008 inflamed blood vessel cell phenotype http://www.bioassayontology.org/bao#BAO_0170007 inflamed cell phenotype http://www.bioassayontology.org/bao#BAO_0170011 regenerating neuron http://www.bioassayontology.org/bao#BAO_0170009 neuronal cell phenotype http://www.bioassayontology.org/bao#BAO_0170010 developing neuron http://www.bioassayontology.org/bao#BAO_0170009 neuronal cell phenotype http://www.bioassayontology.org/bao#BAO_0170014 necrotic cell phenotype http://www.bioassayontology.org/bao#BAO_0170013 dying cell phenotype http://www.bioassayontology.org/bao#BAO_0170015 apoptotic cell phenotype http://www.bioassayontology.org/bao#BAO_0170013 dying cell phenotype http://www.bioassayontology.org/bao#BAO_0170018 S phase mitotic cell phenotype http://www.bioassayontology.org/bao#BAO_0170016 cell cycle phase phenotype http://www.bioassayontology.org/bao#BAO_0170017 M phase mitotic cell phenotype http://www.bioassayontology.org/bao#BAO_0170016 cell cycle phase phenotype http://www.bioassayontology.org/bao#BAO_0170020 NF-KappaB p65 translocation phenotype http://www.bioassayontology.org/bao#BAO_0170019 molecular localization phenotype http://www.bioassayontology.org/bao#BAO_0170023 blebbed neurite phenotype http://www.bioassayontology.org/bao#BAO_0170022 neuronal morphology phenotype http://www.bioassayontology.org/bao#BAO_0170026 elongated neurite phenotype http://www.bioassayontology.org/bao#BAO_0170022 neuronal morphology phenotype http://www.bioassayontology.org/bao#BAO_0170025 defasciculated axon bundles phenotype http://www.bioassayontology.org/bao#BAO_0170022 neuronal morphology phenotype http://www.bioassayontology.org/bao#BAO_0170027 fasciculated axons phenotype http://www.bioassayontology.org/bao#BAO_0170022 neuronal morphology phenotype http://www.bioassayontology.org/bao#BAO_0170028 shortened neurite phenotype http://www.bioassayontology.org/bao#BAO_0170022 neuronal morphology phenotype http://www.bioassayontology.org/bao#BAO_0170024 branched neurite phenotype http://www.bioassayontology.org/bao#BAO_0170022 neuronal morphology phenotype http://www.bioassayontology.org/bao#BAO_0180008 Fiji http://www.bioassayontology.org/bao#BAO_0180004 image analysis software http://www.bioassayontology.org/bao#BAO_0180013 MetaXpress http://www.bioassayontology.org/bao#BAO_0180004 image analysis software http://www.bioassayontology.org/bao#BAO_0180016 Volocity 3D Image Analysis Software http://www.bioassayontology.org/bao#BAO_0180004 image analysis software http://www.bioassayontology.org/bao#BAO_0180001 Acapella http://www.bioassayontology.org/bao#BAO_0180004 image analysis software http://www.bioassayontology.org/bao#BAO_0180002 BD AttoVision http://www.bioassayontology.org/bao#BAO_0180004 image analysis software http://www.bioassayontology.org/bao#BAO_0180003 BioImageXD http://www.bioassayontology.org/bao#BAO_0180004 image analysis software http://www.bioassayontology.org/bao#BAO_0180005 CellProfiler http://www.bioassayontology.org/bao#BAO_0180004 image analysis software http://www.bioassayontology.org/bao#BAO_0180011 ImageJ http://www.bioassayontology.org/bao#BAO_0180004 image analysis software http://www.bioassayontology.org/bao#BAO_0180012 MATLAB http://www.bioassayontology.org/bao#BAO_0180004 image analysis software http://www.bioassayontology.org/bao#BAO_0180014 SlideBook software http://www.bioassayontology.org/bao#BAO_0180004 image analysis software http://www.bioassayontology.org/bao#BAO_0180009 IN Cell Investigator http://www.bioassayontology.org/bao#BAO_0180004 image analysis software http://www.bioassayontology.org/bao#BAO_0180010 Icy http://www.bioassayontology.org/bao#BAO_0180004 image analysis software http://www.bioassayontology.org/bao#BAO_0180017 Harmony http://www.bioassayontology.org/bao#BAO_0180004 image analysis software http://www.bioassayontology.org/bao#BAO_0180015 MetaMorph http://www.bioassayontology.org/bao#BAO_0180004 image analysis software http://www.bioassayontology.org/bao#BAO_0180007 DCILabs http://www.bioassayontology.org/bao#BAO_0180004 image analysis software http://www.bioassayontology.org/bao#BAO_0180006 Cellomics BioApplication http://www.bioassayontology.org/bao#BAO_0180004 image analysis software http://www.bioassayontology.org/bao#BAO_0180019 Cufflinks http://www.bioassayontology.org/bao#BAO_0180018 sequencing data alignment software http://www.bioassayontology.org/bao#BAO_0180020 TopHat http://www.bioassayontology.org/bao#BAO_0180018 sequencing data alignment software http://www.bioassayontology.org/bao#BAO_0180021 Bowtie http://www.bioassayontology.org/bao#BAO_0180018 sequencing data alignment software http://www.bioassayontology.org/bao#BAO_0180023 Cuffcompare http://www.bioassayontology.org/bao#BAO_0180022 sequencing data analysis software http://www.bioassayontology.org/bao#BAO_0180024 Cuffdiff http://www.bioassayontology.org/bao#BAO_0180022 sequencing data analysis software http://www.bioassayontology.org/bao#BAO_0000629 4 parameter Hill equation http://www.bioassayontology.org/bao#BAO_0000435 Hill equation http://www.bioassayontology.org/bao#BAO_0000626 3 parameter Hill equation http://www.bioassayontology.org/bao#BAO_0000435 Hill equation http://www.bioassayontology.org/bao#BAO_0150093 NGS Instrument http://www.bioassayontology.org/bao#BAO_0000698 8453 UV-Visible Spectrophotometer http://www.bioassayontology.org/bao#BAO_0002294 genetic algorithm search http://www.bioassayontology.org/bao#BAO_0002293 global minimum search http://www.bioassayontology.org/bao#BAO_0002446 nucleic acid hybridization-based method http://www.bioassayontology.org/bao#BAO_0002445 genotyping method http://www.bioassayontology.org/bao#BAO_0002448 restriction enzyme-based method http://www.bioassayontology.org/bao#BAO_0002445 genotyping method http://www.bioassayontology.org/bao#BAO_0002449 single nucleotide polymorphism genotyping http://www.bioassayontology.org/bao#BAO_0002445 genotyping method http://www.bioassayontology.org/bao#BAO_0002386 GOLD docking method http://www.bioassayontology.org/bao#BAO_0002383 genetic algorithm method http://www.bioassayontology.org/bao#BAO_0002384 AutoDock3 docking method http://www.bioassayontology.org/bao#BAO_0002383 genetic algorithm method http://www.bioassayontology.org/bao#BAO_0002385 DARWIN docking method http://www.bioassayontology.org/bao#BAO_0002383 genetic algorithm method http://www.bioassayontology.org/bao#BAO_0003034 nucleic acid identification and quantitation method http://www.bioassayontology.org/bao#BAO_0003024 gene expression detection method http://www.bioassayontology.org/bao#BAO_0170022 neuronal morphology phenotype http://www.bioassayontology.org/bao#BAO_0170002 morphological phenotype http://www.bioassayontology.org/bao#BAO_0170029 rounded cell phenotype http://www.bioassayontology.org/bao#BAO_0170002 morphological phenotype http://www.bioassayontology.org/bao#BAO_0170030 shrunken cell phenotype http://www.bioassayontology.org/bao#BAO_0170002 morphological phenotype http://www.bioassayontology.org/bao#BAO_0002417 chemiluminescence-linked immunosorbent assay http://www.bioassayontology.org/bao#BAO_0000134 ELISA http://purl.obolibrary.org/obo/DOID_9402 epididymitis http://purl.obolibrary.org/obo/DOID_0080373 epididymis disease http://purl.obolibrary.org/obo/NCBITaxon_5693 Trypanosoma cruzi http://www.bioassayontology.org/bao#BAO_0000662 protozoan http://www.bioassayontology.org/bao#BAO_0040032 NanoBRET http://www.bioassayontology.org/bao#BAO_0002755 fluorescent ligand binding method http://www.bioassayontology.org/bao#BAO_0080033 cell profile http://www.bioassayontology.org/bao#BAO_0002138 gene-expression profile endpoint http://www.bioassayontology.org/bao#BAO_0003046 green flourescent protein gene http://www.bioassayontology.org/bao#BAO_0000582 gene http://www.bioassayontology.org/bao#BAO_0003044 beta galactosidase gene http://www.bioassayontology.org/bao#BAO_0000582 gene http://www.bioassayontology.org/bao#BAO_0003045 chloramphenicol acetyl transferase gene http://www.bioassayontology.org/bao#BAO_0000582 gene http://www.bioassayontology.org/bao#BAO_0003047 luciferase gene http://www.bioassayontology.org/bao#BAO_0000582 gene http://www.bioassayontology.org/bao#BAO_0150037 ion laser http://www.bioassayontology.org/bao#BAO_0150036 gas laser http://www.bioassayontology.org/bao#BAO_0150042 metal vapor laser http://www.bioassayontology.org/bao#BAO_0150036 gas laser http://www.bioassayontology.org/bao#BAO_0150044 nitrogen laser http://www.bioassayontology.org/bao#BAO_0150036 gas laser http://www.bioassayontology.org/bao#BAO_0002725 AlphaScreen Beads http://www.bioassayontology.org/bao#BAO_0000025 bead http://www.bioassayontology.org/bao#BAO_0150018 glycerin immersion lens http://www.bioassayontology.org/bao#BAO_0150016 objective lens http://www.bioassayontology.org/bao#BAO_0150017 air interface objective lens http://www.bioassayontology.org/bao#BAO_0150016 objective lens http://www.bioassayontology.org/bao#BAO_0150019 oil immersion lens http://www.bioassayontology.org/bao#BAO_0150016 objective lens http://www.bioassayontology.org/bao#BAO_0150020 water immersion lens http://www.bioassayontology.org/bao#BAO_0150016 objective lens http://www.bioassayontology.org/bao#BAO_0002079 ATP quantitation using luciferase http://www.bioassayontology.org/bao#BAO_0000164 ATP quantitation http://www.bioassayontology.org/bao#BAO_0150022 area detector http://www.bioassayontology.org/bao#BAO_0150021 image acquisition device http://www.bioassayontology.org/bao#BAO_0150026 spot detector http://www.bioassayontology.org/bao#BAO_0150021 image acquisition device http://www.bioassayontology.org/bao#BAO_0000131 positively correlated http://www.bioassayontology.org/bao#BAO_0000103 endpoint action correlation http://www.bioassayontology.org/bao#BAO_0000140 inversely correlated http://www.bioassayontology.org/bao#BAO_0000103 endpoint action correlation http://www.bioassayontology.org/bao#BAO_0002173 mean http://www.bioassayontology.org/bao#BAO_0002170 endpoint modifier http://www.bioassayontology.org/bao#BAO_0002174 median http://www.bioassayontology.org/bao#BAO_0002170 endpoint modifier http://www.bioassayontology.org/bao#BAO_0002176 standard deviation http://www.bioassayontology.org/bao#BAO_0002170 endpoint modifier http://purl.obolibrary.org/obo/DOID_4 disease A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism. http://purl.obolibrary.org/obo/GO_0004939 beta-adrenergic receptor activity Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein. http://purl.obolibrary.org/obo/GO_0005635 nuclear envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). http://purl.obolibrary.org/obo/GO_0005794 Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. http://purl.obolibrary.org/obo/GO_0006417 regulation of translation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA. http://purl.obolibrary.org/obo/GO_0006470 protein dephosphorylation The process of removing one or more phosphoric residues from a protein. http://purl.obolibrary.org/obo/GO_0006821 chloride transport The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. http://purl.obolibrary.org/obo/GO_0007050 cell cycle arrest A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M). http://purl.obolibrary.org/obo/GO_0007259 receptor signaling pathway via JAK-STAT Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins. http://purl.obolibrary.org/obo/GO_0015893 drug transport The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. http://purl.obolibrary.org/obo/GO_0016310 phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. http://purl.obolibrary.org/obo/GO_0019932 second-messenger-mediated signaling Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell. http://purl.obolibrary.org/obo/GO_0040029 regulation of gene expression, epigenetic Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence. http://purl.obolibrary.org/obo/GO_0043005 neuron projection A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. http://purl.obolibrary.org/obo/GO_0043086 negative regulation of catalytic activity Any process that stops or reduces the activity of an enzyme. http://purl.obolibrary.org/obo/GO_0048812 neuron projection morphogenesis The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites. http://purl.obolibrary.org/obo/GO_0050821 protein stabilization Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation. http://purl.obolibrary.org/obo/GO_0051722 protein C-terminal methylesterase activity Catalysis of the reaction: C-terminal protein amino acid methyl ester + H2O = protein amino acid + methanol. http://purl.obolibrary.org/obo/GO_0005776 autophagosome A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy. http://purl.obolibrary.org/obo/GO_0000302 response to reactive oxygen species Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. http://purl.obolibrary.org/obo/GO_0000380 alternative mRNA splicing, via spliceosome The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition. http://purl.obolibrary.org/obo/GO_0000786 nucleosome A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures. http://purl.obolibrary.org/obo/GO_0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity. http://purl.obolibrary.org/obo/GO_0001666 response to hypoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0002146 obsolete steroid hormone receptor import into nucleus OBSOLETE. The directed movement of a steroid hormone receptor into the nucleus. http://purl.obolibrary.org/obo/GO_0002147 obsolete glucocorticoid receptor import into nucleus OBSOLETE. The directed movement of a glucocorticoid receptor into the nucleus. http://purl.obolibrary.org/obo/GO_0002574 thrombocyte differentiation The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis. http://purl.obolibrary.org/obo/GO_0002673 regulation of acute inflammatory response Any process that modulates the frequency, rate, or extent of an acute inflammatory response. http://purl.obolibrary.org/obo/GO_0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. http://purl.obolibrary.org/obo/GO_0003924 GTPase activity Catalysis of the reaction: GTP + H2O = GDP + phosphate. http://purl.obolibrary.org/obo/GO_0005488 binding The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. http://purl.obolibrary.org/obo/GO_0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. http://purl.obolibrary.org/obo/GO_0005737 cytoplasm All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. http://purl.obolibrary.org/obo/GO_0005739 mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. http://purl.obolibrary.org/obo/GO_0005764 lysosome A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. http://purl.obolibrary.org/obo/GO_0005783 endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). http://purl.obolibrary.org/obo/GO_0005829 cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. http://purl.obolibrary.org/obo/GO_0005886 plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. http://purl.obolibrary.org/obo/GO_0006281 DNA repair The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. http://purl.obolibrary.org/obo/GO_0006355 regulation of transcription, DNA-templated Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. http://purl.obolibrary.org/obo/GO_0006468 protein phosphorylation The process of introducing a phosphate group on to a protein. http://purl.obolibrary.org/obo/GO_0006606 protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus. http://purl.obolibrary.org/obo/GO_0006914 autophagy The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation. http://purl.obolibrary.org/obo/GO_0006915 apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. http://purl.obolibrary.org/obo/GO_0006950 response to stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). http://purl.obolibrary.org/obo/GO_0006954 inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. http://purl.obolibrary.org/obo/GO_0007049 cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. http://purl.obolibrary.org/obo/GO_0007165 signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. http://purl.obolibrary.org/obo/GO_0007186 G protein-coupled receptor signaling pathway A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane. http://purl.obolibrary.org/obo/GO_0007269 neurotransmitter secretion The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission. http://purl.obolibrary.org/obo/GO_0007623 circadian rhythm Any biological process in an organism that recurs with a regularity of approximately 24 hours. http://purl.obolibrary.org/obo/GO_0008283 cell population proliferation The multiplication or reproduction of cells, resulting in the expansion of a cell population. http://purl.obolibrary.org/obo/GO_0009062 fatty acid catabolic process The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. http://purl.obolibrary.org/obo/GO_0010467 gene expression The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. http://purl.obolibrary.org/obo/GO_0010468 regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. http://purl.obolibrary.org/obo/GO_0016301 kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. http://purl.obolibrary.org/obo/GO_0022403 cell cycle phase One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events. http://purl.obolibrary.org/obo/GO_0023014 signal transduction by protein phosphorylation A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate. http://purl.obolibrary.org/obo/GO_0030334 regulation of cell migration Any process that modulates the frequency, rate or extent of cell migration. http://purl.obolibrary.org/obo/GO_0042391 regulation of membrane potential Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. http://purl.obolibrary.org/obo/GO_0046718 viral entry into host cell The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm. http://purl.obolibrary.org/obo/GO_0048666 neuron development The process whose specific outcome is the progression of a neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. http://purl.obolibrary.org/obo/GO_0019079 viral genome replication Any process involved directly in viral genome replication, including viral nucleotide metabolism. http://purl.obolibrary.org/obo/GO_0023052 signaling The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered. http://purl.obolibrary.org/obo/GO_0030027 lamellipodium A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments. http://purl.obolibrary.org/obo/GO_0030424 axon The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. http://purl.obolibrary.org/obo/GO_0031099 regeneration The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass). http://purl.obolibrary.org/obo/GO_0031102 neuron projection regeneration The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage. http://purl.obolibrary.org/obo/GO_0032059 bleb A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses. http://purl.obolibrary.org/obo/GO_0035196 production of miRNAs involved in gene silencing by miRNA Cleavage of stem-loop RNA precursors into microRNAs (miRNAs), a class of small RNAs that primarily silence genes by blocking the translation of mRNA transcripts into protein, or by increasing the degradation of non-protein-coding RNA transcripts. http://purl.obolibrary.org/obo/GO_0043484 regulation of RNA splicing Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. http://purl.obolibrary.org/obo/GO_0061136 regulation of proteasomal protein catabolic process Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome. http://purl.obolibrary.org/obo/GO_0036166 phenotypic switching A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues. http://purl.obolibrary.org/obo/GO_0042710 biofilm formation A process in which planktonically growing microorganisms grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription. http://purl.obolibrary.org/obo/GO_0043491 protein kinase B signaling A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound. http://purl.obolibrary.org/obo/GO_0044297 cell body The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections. http://purl.obolibrary.org/obo/GO_0044303 axon collateral Any of the smaller branches of an axon that emanate from the main axon cylinder. http://purl.obolibrary.org/obo/GO_0044307 dendritic branch A dendrite arising from another dendrite. http://purl.obolibrary.org/obo/GO_0051090 regulation of DNA-binding transcription factor activity Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription. http://purl.obolibrary.org/obo/GO_0051438 regulation of ubiquitin-protein transferase activity Any process that modulates the frequency, rate or extent of ubiquitin transferase activity. http://purl.obolibrary.org/obo/GO_1901589 axon microtubule bundle An arrangement of closely apposed microtubules running parallel to each other in the axon hillock and initial segment. http://purl.obolibrary.org/obo/GO_0008219 cell death Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538). http://purl.obolibrary.org/obo/GO_0009372 quorum sensing The cell-cell signaling process in which single-celled organisms carry out coordinated responses by monitoring their own population density, and often also that of other microbes, by producing small, diffusible, signal molecules, detecting the concentration of these molecules, and triggering a signal transduction pathway when a certain threshold is reached. Quorum sensing can occur amongst microbial communities in the environment or within host organisms. http://purl.obolibrary.org/obo/GO_0009986 cell surface The external part of the cell wall and/or plasma membrane. http://purl.obolibrary.org/obo/GO_0010737 protein kinase A signaling A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound. http://purl.obolibrary.org/obo/GO_0010884 positive regulation of lipid storage Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. http://purl.obolibrary.org/obo/GO_0010888 negative regulation of lipid storage Any process that decreases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. http://purl.obolibrary.org/obo/GO_0016032 viral process A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle. http://purl.obolibrary.org/obo/GO_0016246 RNA interference The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes. http://purl.obolibrary.org/obo/GO_0030168 platelet activation A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug. http://purl.obolibrary.org/obo/GO_0042493 response to drug Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease. http://purl.obolibrary.org/obo/GO_0050790 regulation of catalytic activity Any process that modulates the activity of an enzyme. http://purl.obolibrary.org/obo/GO_0065009 regulation of molecular function Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. http://purl.obolibrary.org/obo/GO_0070265 necrotic cell death A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues. http://purl.obolibrary.org/obo/GO_0060964 regulation of gene silencing by miRNA Any process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: RNA (often mRNA) cleavage or mRNA translational repression. http://purl.obolibrary.org/obo/GO_0070528 protein kinase C signaling A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound. http://purl.obolibrary.org/obo/GO_0071712 ER-associated misfolded protein catabolic process The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. http://purl.obolibrary.org/obo/GO_0071964 establishment of cell polarity regulating cell shape Any cellular process that results in the specification or formation of a polarized intracellular organization or cell growth pattern that regulates the shape of a cell. http://www.bioassayontology.org/bao#BAO_0002934 organization Organization in BAO is the organizational affiliation of individuals / people or laboratories that develop assays or perform screens or manufacture, commercialize entities used in performing assay experiments (assay kits, instruments, etc). http://www.bioassayontology.org/bao#BAO_0010073 assay screening throughput This descripts the relative maximum throughput of an assay in regards to its screening potential. http://www.bioassayontology.org/bao#BAO_0002929 role http://www.bioassayontology.org/bao#BAO_0002928 quality http://www.bioassayontology.org/bao#BAO_0003114 assay biology component http://www.bioassayontology.org/bao#BAO_0002737 regulation of catalytic activity http://www.bioassayontology.org/bao#BAO_0002753 assay method component http://www.bioassayontology.org/bao#BAO_0002889 calcium-mediated signaling using intracellular calcium http://www.bioassayontology.org/bao#BAO_0002890 G-protein coupled receptor signaling http://www.bioassayontology.org/bao#BAO_0002891 cAMP-mediated http://www.bioassayontology.org/bao#BAO_0003112 assay bioassay component http://www.bioassayontology.org/bao#BAO_0003113 assay format component http://www.bioassayontology.org/bao#BAO_0003115 assay result component http://www.bioassayontology.org/bao#BAO_0003120 assay screened entity component http://www.bioassayontology.org/bao#BAO_0165000 people http://www.bioassayontology.org/bao#BAO_0002814 has gene copy number http://www.bioassayontology.org/bao#BAO_0002813 has copy number This describes the number of repeats of a gene of interest cloned in a DNA construct. http://www.bioassayontology.org/bao#BAO_0002815 has cDNA copy number http://www.bioassayontology.org/bao#BAO_0002813 has copy number This describes the number of repeats of a cDNA of interest cloned in a DNA construct. http://www.bioassayontology.org/bao#BAO_0002816 has artificial regulatory region copy number http://www.bioassayontology.org/bao#BAO_0002813 has copy number This describes the number of repeats of an artificial regulatory element present in a DNA construct. http://www.bioassayontology.org/bao#BAO_0002834 has cell modification time value http://www.bioassayontology.org/bao#BAO_0002833 has incubation time value It is the interval of time between the cell modification, namely transient transfection of plasmid DNA/ siRNA, viral transduction, etc and the measurement of change, as observed by a detection method in the bioassay. http://www.bioassayontology.org/bao#BAO_0002836 has enzyme reaction time value http://www.bioassayontology.org/bao#BAO_0002833 has incubation time value It is the interval of time between the enzyme activity measurement in a kinetic assay. http://www.bioassayontology.org/bao#BAO_0002837 has perturbagen incubation time value http://www.bioassayontology.org/bao#BAO_0002833 has incubation time value It is the interval of time between the addition of a perturbagen and the measurement of change, as observed by a detection method in the bioassay. http://www.bioassayontology.org/bao#BAO_0002838 has substrate incubation time value http://www.bioassayontology.org/bao#BAO_0002833 has incubation time value It is the interval of time between the addition of an enzyme substrate and the measurement of change, as observed by a detection/ readout in a bioassay. http://www.bioassayontology.org/bao#BAO_0002894 has shRNA probe sense sequence position http://www.bioassayontology.org/bao#BAO_0002893 has sequence position The nucleotide number in the sense strand of a gene that marks the beginning and end of the shRNA probe. http://www.bioassayontology.org/bao#BAO_0002895 has siRNA probe sense sequence position http://www.bioassayontology.org/bao#BAO_0002893 has sequence position The nucleotide number in the sense strand of a gene that marks the beginning and end of the siRNA probe. http://www.bioassayontology.org/bao#BAO_0002823 has sense strand sequence http://www.bioassayontology.org/bao#BAO_0000300 has DNA 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an entity (e.g., artificial regulatory element, cDNA, etc.) present in a DNA construct. http://www.bioassayontology.org/bao#BAO_0002826 has biosafety level A biosafety level is the level of biocontainment required to isolate hazardous biological agents in an enclosed facility. The levels of containment range from the lowest biosafety level of 1 to the highest at level 4. The levels are as follows: BSL1: Suitable for work involving well-characterized agents not known to consistently cause disease in immunocompetent adult humans, and present minimal potential hazard to laboratory personnel and the environment (definition from CDC). BSL2: Suitable for work involving agents that pose moderate hazards to personnel and the environment. It differs from BSL-1 in that 1) laboratory personnel have specific training in handling pathogenic agents and are supervised by scientists competent in handling infectious agents and associated procedures; 2) access to the laboratory is restricted when work is being conducted; and 3) all procedures in which infectious aerosols or splashes may be created are conducted in BSCs or other physical containment equipment (definition from CDC). BSL3: Suitable for clinical, diagnostic, teaching, research, or production facilities where work is performed with indigenous or exotic agents that may cause serious or potentially lethal disease through inhalation route exposure. Laboratory personnel must receive specific training in handling pathogenic and potentially lethal agents, and must be supervised by scientists competent in handling infectious agents and associated procedures. All procedures involving the manipulation of infectious materials must be conducted within BSCs, other physical containment devices, or by personnel wearing appropriate personal protective equipment (definition from CDC). BSL4: http://www.bioassayontology.org/bao#BAO_0002827 has assay pH value pH approximates the negative logarithm (base 10) of the molar concentration of dissolved hydronium ions in a solution. http://www.bioassayontology.org/bao#BAO_0002828 has assay pressure value It is the force per unit area applied in a direction perpendicular to the surface of an object in an assay. http://www.bioassayontology.org/bao#BAO_0002832 has assay temperature value It is the temperature at which the biological experiment was conducted. http://www.bioassayontology.org/bao#BAO_0002833 has incubation time value It is the interval of time between the addition of a perturbagen, substrate or cell modification and the measurement of change, as observed by a detection method in the bioassay. http://www.bioassayontology.org/bao#BAO_0002845 has repetition point-number The number of replicate measurements (repetitions) per concentration value used. http://www.bioassayontology.org/bao#BAO_0002916 has activity threshold value The value (in conjunction with the signal direction) used to determine perturbagens of interest (hits.) Perturbagens with a readout value beyond the threshold in the direction of interest are considered active in the assay. http://www.bioassayontology.org/bao#BAO_0090001 has function in c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p. http://www.bioassayontology.org/bao#BAO_0090011 connected to X connected_to Y if and only if X and Y share a fiat boundary. http://www.bioassayontology.org/bao#BAO_0002659 encodes http://www.bioassayontology.org/bao#BAO_0090008 bearer of http://www.bioassayontology.org/bao#BAO_0002665 uses as substrate http://www.bioassayontology.org/bao#BAO_0002872 is unit of http://www.bioassayontology.org/bao#BAO_0000210 has assay stage http://www.bioassayontology.org/bao#BAO_0000207 has detection method http://www.bioassayontology.org/bao#BAO_0002846 has assay protocol http://www.bioassayontology.org/bao#BAO_0000106 has marker http://www.bioassayontology.org/bao#BAO_0000108 has response value 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derives from http://www.bioassayontology.org/bao#BAO_0090007 occurs in http://www.bioassayontology.org/bao#BAO_0090009 inheres in http://www.bioassayontology.org/bao#BAO_0090010 contains process http://www.bioassayontology.org/bao#BAO_0090012 has participant http://www.bioassayontology.org/bao#BAO_0090013 participates in http://www.bioassayontology.org/bao#BAO_0095000 is derived from http://www.bioassayontology.org/bao#BAO_0095001 detects phenotype http://www.bioassayontology.org/bao#BAO_0095002 has indicator http://www.bioassayontology.org/bao#BAO_0095003 is described by http://www.bioassayontology.org/bao#BAO_0095004 quantifies http://www.bioassayontology.org/bao#BAO_0095007 has value http://www.bioassayontology.org/bao#BAO_0095008 reports assay measurment value http://www.bioassayontology.org/bao#BAO_0095009 has assay design method http://www.bioassayontology.org/bao#BAO_0095010 has assay supporting method http://www.bioassayontology.org/bao#BAO_0002663 uses assay kit 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