Term IRI Term label Parent term IRI Parent term label Alternative term Definition http://purl.obolibrary.org/obo/PATO_0001987 saccular http://purl.obolibrary.org/obo/PATO_0002014 structure, cavities sacular A structural quality inhering in a bearer by virtue of the bearer's having a three dimensional cavity with a narrow or no opening, and often containing an anatomical substance. http://purl.obolibrary.org/obo/CARO_0000014 cell part http://purl.obolibrary.org/obo/CARO_0000003 connected anatomical structure cell component Anatomical structure that is part of a cell and that has a granularity level equal to that of a protein complex or higher. http://purl.obolibrary.org/obo/CARO_0000029 hermaphroditic organism http://purl.obolibrary.org/obo/CARO_0000012 multicellular organism dioecious organism Multi-cellular organism that can produce both male and female gametes. http://purl.obolibrary.org/obo/CARO_0000043 tissue http://purl.obolibrary.org/obo/CARO_0010000 multicellular anatomical structure portion of tissue Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation. http://purl.obolibrary.org/obo/CARO_0000045 sequential hermaphroditic organism http://purl.obolibrary.org/obo/CARO_0000029 hermaphroditic organism consecutive hermaphroditic organism Hermaphroditic organism that produces gametes first of one sex, and then later of the other sex. http://purl.obolibrary.org/obo/CARO_0000046 synchronous hermaphroditic organism http://purl.obolibrary.org/obo/CARO_0000029 hermaphroditic organism serially hermaphroditic organism Hermaphroditic organism that produces both male and female gametes at the same time. http://purl.obolibrary.org/obo/CARO_0000048 gonochoristic organism http://purl.obolibrary.org/obo/CARO_0000012 multicellular organism monoecious organism Multi-cellular organism that has male and female sexes. http://purl.obolibrary.org/obo/CARO_0000064 unicellular organism http://purl.obolibrary.org/obo/CARO_0010004 cellular organism single-cell organism Organism that consists of a single cell for all of its life-cycle. http://purl.obolibrary.org/obo/CARO_0001000 multi-cell-part structure http://purl.obolibrary.org/obo/CARO_0001008 gross anatomical part multi-cell-component structure A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part. http://purl.obolibrary.org/obo/CARO_0001001 neuron projection bundle http://purl.obolibrary.org/obo/CARO_0001000 multi-cell-part structure nerve fiber bundle A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses. http://purl.obolibrary.org/obo/CHEBI_15841 polypeptide http://purl.obolibrary.org/obo/CHEBI_33839 macromolecule A peptide containing ten or more amino acid residues. http://purl.obolibrary.org/obo/CHEBI_25512 neurotransmitter http://purl.obolibrary.org/obo/CHEBI_33280 molecular messenger An endogenous compound that is used to transmit information across the synapse between a neuron and another cell. http://purl.obolibrary.org/obo/CHEBI_26191 polyol http://purl.obolibrary.org/obo/CHEBI_33822 organic hydroxy compound A compound that contains two or more hydroxy groups. http://purl.obolibrary.org/obo/CHEBI_32952 amine http://purl.obolibrary.org/obo/CHEBI_50047 organic amino compound A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. http://purl.obolibrary.org/obo/CHEBI_33567 catecholamine http://purl.obolibrary.org/obo/CHEBI_25375 monoamine molecular messenger 4-(2-Aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] and derivatives formed by substitution. http://purl.obolibrary.org/obo/CHEBI_33822 organic hydroxy compound http://purl.obolibrary.org/obo/CHEBI_50860 organic molecular entity An organic compound having at least one hydroxy group attached to a carbon atom. http://purl.obolibrary.org/obo/CHEBI_38101 organonitrogen heterocyclic compound http://purl.obolibrary.org/obo/CHEBI_35352 organonitrogen compound Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms. http://purl.obolibrary.org/obo/CHEBI_50904 allergen http://purl.obolibrary.org/obo/CHEBI_52209 aetiopathogenetic role A chemical compound, or part thereof, which causes the onset of an allergic reaction by interacting with any of the molecular pathways involved in an allergy. http://purl.obolibrary.org/obo/CHEBI_5686 heterocyclic compound http://purl.obolibrary.org/obo/CHEBI_33595 cyclic compound A cyclic compound having as ring members atoms of at least two different elements. http://purl.obolibrary.org/obo/CHEBI_83056 Daphnia magna metabolite http://purl.obolibrary.org/obo/CHEBI_83057 Daphnia metabolite A Daphnia metabolite produced by the species Daphnia magna. http://purl.obolibrary.org/obo/CHEBI_84729 hydroxyindoles http://purl.obolibrary.org/obo/CHEBI_24828 indoles Any member of the class of indoles carrying at least one hydroxy group. http://purl.obolibrary.org/obo/CHEBI_28965 dicarboxylic acid dianion http://purl.obolibrary.org/obo/CHEBI_38716 carboxylic acid dianion A carboxylic acid dianion obtained by deprotonation of both carboxy groups of any dicarboxylic acid. http://purl.obolibrary.org/obo/CHEBI_33707 gamma-amino acid http://purl.obolibrary.org/obo/CHEBI_83820 non-proteinogenic amino acid A non-proteinogenic amino-acid in which the amino group is located on the carbon atom at the position gamma to the carboxy group. http://purl.obolibrary.org/obo/CHEBI_64049 food acidity regulator http://purl.obolibrary.org/obo/CHEBI_64047 food additive A food additive that is used to change or otherwise control the acidity or alkalinity of foods. They may be acids, bases, neutralising agents or buffering agents. http://purl.obolibrary.org/obo/CHEBI_131927 dicarboxylic acids and O-substituted derivatives http://purl.obolibrary.org/obo/CHEBI_36586 carbonyl compound A class of carbonyl compound encompassing dicarboxylic acids and any derivatives obtained by substitution of either one or both of the carboxy hydrogens. http://purl.obolibrary.org/obo/CHEBI_15366 acetic acid http://purl.obolibrary.org/obo/CHEBI_25384 monocarboxylic acid A simple monocarboxylic acid containing two carbons. http://purl.obolibrary.org/obo/CHEBI_16765 tryptamine http://purl.obolibrary.org/obo/CHEBI_64365 aralkylamino compound An aminoalkylindole consisting of indole having a 2-aminoethyl group at the 3-position. http://purl.obolibrary.org/obo/CHEBI_18059 lipid http://purl.obolibrary.org/obo/CHEBI_50860 organic molecular entity 'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids. http://purl.obolibrary.org/obo/CHEBI_18295 histamine http://purl.obolibrary.org/obo/CHEBI_64365 aralkylamino compound An aralkylamine that has formula C5H9N3. http://purl.obolibrary.org/obo/CHEBI_23357 cofactor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group). http://purl.obolibrary.org/obo/CHEBI_23824 diol http://purl.obolibrary.org/obo/CHEBI_26191 polyol A compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. Aliphatic diols are also called glycols. http://purl.obolibrary.org/obo/CHEBI_24833 oxoacid http://purl.obolibrary.org/obo/CHEBI_24651 hydroxides A compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons). http://purl.obolibrary.org/obo/CHEBI_25367 molecule http://purl.obolibrary.org/obo/CHEBI_36357 polyatomic entity Any polyatomic entity that is an electrically neutral entity consisting of more than one atom. http://purl.obolibrary.org/obo/CHEBI_25696 organic anion http://purl.obolibrary.org/obo/CHEBI_25699 organic ion Any organic ion with a net negative charge. http://purl.obolibrary.org/obo/CHEBI_26607 saturated fatty acid http://purl.obolibrary.org/obo/CHEBI_35366 fatty acid Any fatty acid containing no carbon to carbon multiple bonds. Known to produce adverse biological effects when ingested to excess. http://purl.obolibrary.org/obo/CHEBI_27369 zwitterion http://purl.obolibrary.org/obo/CHEBI_51151 dipolar compound A neutral compound having formal unit electrical charges of opposite sign on non-adjacent atoms. Sometimes referred to as inner salts, dipolar ions (a misnomer). http://purl.obolibrary.org/obo/CHEBI_29067 carboxylic acid anion http://purl.obolibrary.org/obo/CHEBI_35406 oxoanion The conjugate base formed when the carboxy group of a carboxylic acid is deprotonated. http://purl.obolibrary.org/obo/CHEBI_30089 acetate http://purl.obolibrary.org/obo/CHEBI_35757 monocarboxylic acid anion A monocarboxylic acid anion resulting from the removal of a proton from the carboxy group of acetic acid. http://purl.obolibrary.org/obo/CHEBI_33247 organic group http://purl.obolibrary.org/obo/CHEBI_24433 group Any substituent group or skeleton containing carbon. http://purl.obolibrary.org/obo/CHEBI_33708 amino-acid residue http://purl.obolibrary.org/obo/CHEBI_33247 organic group When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue. http://purl.obolibrary.org/obo/CHEBI_33893 reagent http://purl.obolibrary.org/obo/CHEBI_33232 application A substance used in a chemical reaction to detect, measure, examine, or produce other substances. http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor http://purl.obolibrary.org/obo/CHEBI_24432 biological role A substance that diminishes the rate of a chemical reaction. http://purl.obolibrary.org/obo/CHEBI_35238 amino acid zwitterion http://purl.obolibrary.org/obo/CHEBI_27369 zwitterion The zwitterionic form of an amino acid having a negatively charged carboxyl group and a positively charged amino group. http://purl.obolibrary.org/obo/CHEBI_36587 organic oxo compound http://purl.obolibrary.org/obo/CHEBI_72695 organic molecule Organic compounds containing an oxygen atom, =O, doubly bonded to carbon or another element. http://purl.obolibrary.org/obo/CHEBI_47622 acetate ester http://purl.obolibrary.org/obo/CHEBI_33308 carboxylic ester Any carboxylic ester where the carboxylic acid component is acetic acid. http://purl.obolibrary.org/obo/CHEBI_48356 protic solvent http://purl.obolibrary.org/obo/CHEBI_48354 polar solvent A polar solvent that is capable of acting as a hydron (proton) donor. http://purl.obolibrary.org/obo/CHEBI_48705 agonist http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role Substance which binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own. http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role http://purl.obolibrary.org/obo/CHEBI_24432 biological role A biological role played by the molecular entity or part thereof within a biochemical context. http://purl.obolibrary.org/obo/CHEBI_52217 pharmaceutical http://purl.obolibrary.org/obo/CHEBI_33232 application Any substance introduced into a living organism with therapeutic or diagnostic purpose. http://purl.obolibrary.org/obo/CHEBI_58953 saturated fatty acid anion http://purl.obolibrary.org/obo/CHEBI_28868 fatty acid anion Any fatty acid anion in which there is no C-C unsaturation. http://purl.obolibrary.org/obo/CHEBI_61120 nucleobase-containing molecular entity http://purl.obolibrary.org/obo/CHEBI_33833 heteroarene Any compound that has a nucleobase as a part. http://purl.obolibrary.org/obo/CHEBI_62488 signalling molecule http://purl.obolibrary.org/obo/CHEBI_33280 molecular messenger A molecular messenger in which the molecule is specifically involved in transmitting information between cells. Such molecules are released from the cell sending the signal, cross over the gap between cells by diffusion, and interact with specific receptors in another cell, triggering a response in that cell by activating a series of enzyme controlled reactions which lead to changes inside the cell. http://purl.obolibrary.org/obo/CHEBI_64909 poison http://purl.obolibrary.org/obo/CHEBI_24432 biological role Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism. http://purl.obolibrary.org/obo/CHEBI_65255 food preservative http://purl.obolibrary.org/obo/CHEBI_64047 food additive Substances which are added to food in order to prevent decomposition caused by microbial growth or by undesirable chemical changes. http://purl.obolibrary.org/obo/CHEBI_65296 primary ammonium ion http://purl.obolibrary.org/obo/CHEBI_35274 ammonium ion derivative An ammonium ion derivative resulting from the protonation of the nitrogen atom of a primary amino compound. Major species at pH 7.3. http://purl.obolibrary.org/obo/CHEBI_75768 mammalian metabolite http://purl.obolibrary.org/obo/CHEBI_75767 animal metabolite Any animal metabolite produced during a metabolic reaction in mammals. http://purl.obolibrary.org/obo/CHEBI_78608 alpha-amino acid zwitterion http://purl.obolibrary.org/obo/CHEBI_35238 amino acid zwitterion An amino acid zwitterion obtained by transfer of a proton from the carboxy to the amino group of any alpha-amino acid; major species at pH 7.3. http://purl.obolibrary.org/obo/CHEBI_83039 crustacean metabolite http://purl.obolibrary.org/obo/CHEBI_75767 animal metabolite An animal metabolite produced by arthropods such as crabs, lobsters, crayfish, shrimps and krill. http://purl.obolibrary.org/obo/CHEBI_84087 human urinary metabolite http://purl.obolibrary.org/obo/CHEBI_77746 human metabolite Any metabolite (endogenous or exogenous) found in human urine samples. http://purl.obolibrary.org/obo/CHEBI_22221 acyl group http://purl.obolibrary.org/obo/CHEBI_33247 organic group An organic group formed by removing one or more hydroxy groups from an oxoacid that has the general structure RkE(=O)l(OH)m (l =/= 0). Although the term is almost always applied to organic compounds, with carboxylic acid as the oxoacid, acyl groups can in principle be derived from other types of acids such as sulfonic acids or phosphonic acids. http://purl.obolibrary.org/obo/CHEBI_22563 anion http://purl.obolibrary.org/obo/CHEBI_24870 ion A monoatomic or polyatomic species having one or more elementary charges of the electron. http://purl.obolibrary.org/obo/CHEBI_23004 carbamoyl group http://purl.obolibrary.org/obo/CHEBI_27207 univalent carboacyl group The univalent carboacyl group formed by loss of -OH from the carboxy group of carbamic acid. http://purl.obolibrary.org/obo/CHEBI_23367 molecular entity http://purl.obolibrary.org/obo/CHEBI_24431 chemical entity Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity. http://purl.obolibrary.org/obo/CHEBI_23677 diazole http://purl.obolibrary.org/obo/CHEBI_68452 azole Either one of a pair of heterocyclic organic compounds comprising three carbon atoms and two nitrogen atoms arranged in a ring. http://purl.obolibrary.org/obo/CHEBI_24431 chemical entity http://purl.obolibrary.org/obo/BFO_0000040 material entity A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances. http://purl.obolibrary.org/obo/CHEBI_24432 biological role http://purl.obolibrary.org/obo/BFO_0000023 role A role played by the molecular entity or part thereof within a biological context. http://purl.obolibrary.org/obo/CHEBI_24532 organic heterocyclic compound http://purl.obolibrary.org/obo/CHEBI_33832 organic cyclic compound A cyclic compound having as ring members atoms of carbon and at least of one other element. http://purl.obolibrary.org/obo/CHEBI_24651 hydroxides http://purl.obolibrary.org/obo/CHEBI_37577 heteroatomic molecular entity Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-)). http://purl.obolibrary.org/obo/CHEBI_24835 inorganic molecular entity http://purl.obolibrary.org/obo/CHEBI_23367 molecular entity A molecular entity that contains no carbon. http://purl.obolibrary.org/obo/CHEBI_24870 ion http://purl.obolibrary.org/obo/CHEBI_23367 molecular entity A molecular entity having a net electric charge. http://purl.obolibrary.org/obo/CHEBI_25741 oxide http://purl.obolibrary.org/obo/CHEBI_37577 heteroatomic molecular entity An oxide is a chemical compound of oxygen with other chemical elements. http://purl.obolibrary.org/obo/CHEBI_26167 polar amino acid http://purl.obolibrary.org/obo/CHEBI_33709 amino acid Any amino acid whose side chain is capable of forming one or more hydrogen bonds. http://purl.obolibrary.org/obo/CHEBI_26469 quaternary nitrogen compound http://purl.obolibrary.org/obo/CHEBI_35352 organonitrogen compound A nitrogen molecular entity that is electronically neutral but which contains a quaternary nitrogen. http://purl.obolibrary.org/obo/CHEBI_32988 amide http://purl.obolibrary.org/obo/CHEBI_51143 nitrogen molecular entity An amide is a derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group. http://purl.obolibrary.org/obo/CHEBI_33232 application http://purl.obolibrary.org/obo/BFO_0000023 role Intended use of the molecular entity or part thereof by humans. http://purl.obolibrary.org/obo/CHEBI_33250 atom http://purl.obolibrary.org/obo/CHEBI_24431 chemical entity A chemical entity constituting the smallest component of an element having the chemical properties of the element. http://purl.obolibrary.org/obo/CHEBI_33253 nucleon http://purl.obolibrary.org/obo/CHEBI_36347 nuclear particle Heavy nuclear particle: proton or neutron. http://purl.obolibrary.org/obo/CHEBI_33285 heteroorganic entity http://purl.obolibrary.org/obo/CHEBI_50860 organic molecular entity A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms. http://purl.obolibrary.org/obo/CHEBI_33300 pnictogen http://purl.obolibrary.org/obo/CHEBI_33560 p-block element atom Any p-block element atom that is in group 15 of the periodic table: nitrogen, phosphorus, arsenic, antimony and bismuth. http://purl.obolibrary.org/obo/CHEBI_33302 pnictogen molecular entity http://purl.obolibrary.org/obo/CHEBI_33675 p-block molecular entity A p-block molecular entity containing any pnictogen. http://purl.obolibrary.org/obo/CHEBI_33303 chalcogen http://purl.obolibrary.org/obo/CHEBI_33560 p-block element atom Any p-block element belonging to the group 16 family of the periodic table. http://purl.obolibrary.org/obo/CHEBI_33304 chalcogen molecular entity http://purl.obolibrary.org/obo/CHEBI_33675 p-block molecular entity Any p-block molecular entity containing a chalcogen. http://purl.obolibrary.org/obo/CHEBI_33318 main group element atom http://purl.obolibrary.org/obo/CHEBI_33250 atom An atom belonging to one of the main groups (found in the s- and p- blocks) of the periodic table. http://purl.obolibrary.org/obo/CHEBI_33560 p-block element atom http://purl.obolibrary.org/obo/CHEBI_33318 main group element atom Any main group element atom belonging to the p-block of the periodic table. http://purl.obolibrary.org/obo/CHEBI_33675 p-block molecular entity http://purl.obolibrary.org/obo/CHEBI_33579 main group molecular entity A p-block molecular entity is a molecular entity containing one or more atoms of a p-block element. http://purl.obolibrary.org/obo/CHEBI_33832 organic cyclic compound http://purl.obolibrary.org/obo/CHEBI_33595 cyclic compound Any organic molecule that consists of atoms connected in the form of a ring. http://purl.obolibrary.org/obo/CHEBI_33937 macronutrient http://purl.obolibrary.org/obo/CHEBI_33284 nutrient Any nutrient required in large quantities by organisms throughout their life in order to orchestrate a range of physiological functions. Macronutrients are usually chemical elements (carbon, hydrogen, nitrogen, oxygen, phosphorus and sulfur) that humans consume in the largest quantities. Calcium, sodium, magnesium and potassium are sometimes included as macronutrients because they are required in relatively large quantities compared with other vitamins and minerals. http://purl.obolibrary.org/obo/CHEBI_35406 oxoanion http://purl.obolibrary.org/obo/CHEBI_33273 polyatomic anion An oxoanion is an anion derived from an oxoacid by loss of hydron(s) bound to oxygen. http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function. http://purl.obolibrary.org/obo/CHEBI_36357 polyatomic entity http://purl.obolibrary.org/obo/CHEBI_23367 molecular entity Any molecular entity consisting of more than one atom. http://purl.obolibrary.org/obo/CHEBI_36358 polyatomic ion http://purl.obolibrary.org/obo/CHEBI_36357 polyatomic entity An ion consisting of more than one atom. http://purl.obolibrary.org/obo/CHEBI_36916 cation http://purl.obolibrary.org/obo/CHEBI_24870 ion A monoatomic or polyatomic species having one or more elementary charges of the proton. http://purl.obolibrary.org/obo/CHEBI_36962 organochalcogen compound http://purl.obolibrary.org/obo/CHEBI_33304 chalcogen molecular entity An organochalcogen compound is a compound containing at least one carbon-chalcogen bond. http://purl.obolibrary.org/obo/CHEBI_37577 heteroatomic molecular entity http://purl.obolibrary.org/obo/CHEBI_36357 polyatomic entity A molecular entity consisting of two or more chemical elements. http://purl.obolibrary.org/obo/CHEBI_37838 carboacyl group http://purl.obolibrary.org/obo/CHEBI_22221 acyl group A carboacyl group is a group formed by loss of at least one OH from the carboxy group of a carboxylic acid. http://purl.obolibrary.org/obo/CHEBI_39141 Bronsted acid http://purl.obolibrary.org/obo/CHEBI_37527 acid A molecular entity capable of donating a hydron to an acceptor (Bronsted base). http://purl.obolibrary.org/obo/CHEBI_50325 proteinogenic amino-acid side-chain group http://purl.obolibrary.org/obo/CHEBI_33249 organyl group A univalent organyl group obtained by cleaving the bond from C-2 to the side chain of a proteinogenic amino-acid. http://purl.obolibrary.org/obo/CHEBI_50906 role http://purl.obolibrary.org/obo/BFO_0000023 role A role is particular behaviour which a material entity may exhibit. http://purl.obolibrary.org/obo/CHEBI_51422 organodiyl group http://purl.obolibrary.org/obo/CHEBI_51446 organic divalent group Any organic substituent group, regardless of functional type, having two free valences at carbon atom(s). http://purl.obolibrary.org/obo/CHEBI_59650 amino fatty acid http://purl.obolibrary.org/obo/CHEBI_60690 nitrogen-containing fatty acid A fatty acid containing at least one amino substituent. http://purl.obolibrary.org/obo/CHEBI_63534 monoamine http://purl.obolibrary.org/obo/CHEBI_64365 aralkylamino compound An aralylamino compound which contains one amino group connected to an aromatic ring by a two-carbon chain. Monoamines are derived from aromatic amino acids like phenylalanine, tyrosine, tryptophan, and the thyroid hormones by the action of aromatic amino acid decarboxylase enzymes. http://purl.obolibrary.org/obo/CHEBI_68452 azole http://purl.obolibrary.org/obo/CHEBI_38179 monocyclic heteroarene Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen. http://purl.obolibrary.org/obo/CHEBI_83820 non-proteinogenic amino acid http://purl.obolibrary.org/obo/CHEBI_33709 amino acid Any amino-acid that is not naturally encoded in the genetic code of any organism. http://purl.obolibrary.org/obo/CHEBI_39142 Bronsted base http://purl.obolibrary.org/obo/CHEBI_22695 base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). http://purl.obolibrary.org/obo/CHEBI_39144 Lewis base http://purl.obolibrary.org/obo/CHEBI_22695 base A molecular entity able to provide a pair of electrons and thus capable of forming a covalent bond with an electron-pair acceptor (Lewis acid), thereby producing a Lewis adduct. http://purl.obolibrary.org/obo/CHEBI_73398 indole skeleton http://purl.obolibrary.org/obo/CHEBI_73541 organic heterobicyclic ring A mancude heterobicyclic organic group consisting of a benzene ring fused to a pyrrole ring. http://purl.obolibrary.org/obo/CHEBI_52209 aetiopathogenetic role http://purl.obolibrary.org/obo/CHEBI_24432 biological role A role played by the molecular entity or part thereof which causes the development of a pathological process. http://purl.obolibrary.org/obo/CHEBI_61008 nitrogen-containing fatty acid anion http://purl.obolibrary.org/obo/CHEBI_28868 fatty acid anion A fatty acid anion arising from deprotonation of the carboxylic acid group of any nitrogen-containing fatty acid. http://purl.obolibrary.org/obo/CHEBI_73541 organic heterobicyclic ring http://purl.obolibrary.org/obo/CHEBI_52845 cyclic organic group A bicyclic organic group that contains both carbon and hetero atoms. http://purl.obolibrary.org/obo/CHEBI_83057 Daphnia metabolite http://purl.obolibrary.org/obo/CHEBI_83039 crustacean metabolite A crustacean metabolite produced by the genus of small planktonic arthropods, Daphnia http://purl.obolibrary.org/obo/PR_000050567 protein-containing material entity http://purl.obolibrary.org/obo/BFO_0000040 material entity A material entity that minimally consists of a protein. http://purl.obolibrary.org/obo/PATO_0000001 quality http://purl.obolibrary.org/obo/BFO_0000020 specifically dependent continuant A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities. http://purl.obolibrary.org/obo/PATO_0000051 morphology http://purl.obolibrary.org/obo/PATO_0001241 physical object quality A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure. http://purl.obolibrary.org/obo/PATO_0000052 shape http://purl.obolibrary.org/obo/PATO_0000051 morphology A morphological quality inhering in a bearer by virtue of the bearer's ratios of distances between its features (points, edges, surfaces and also holes etc). http://purl.obolibrary.org/obo/PATO_0000141 structure http://purl.obolibrary.org/obo/PATO_0000051 morphology A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form. http://purl.obolibrary.org/obo/PATO_0000411 circular http://purl.obolibrary.org/obo/PATO_0000947 elliptic A shape quality inhering in a bearer by virtue of the bearer's being such that every part of the surface or the circumference is equidistant from the center. http://purl.obolibrary.org/obo/PATO_0000947 elliptic http://purl.obolibrary.org/obo/PATO_0002318 superelliptic A spheroid quality inhering in a bearer by virtue of the bearer's being oval with two axes of symmetry, as produced by a conical section. http://purl.obolibrary.org/obo/PATO_0001018 physical quality http://purl.obolibrary.org/obo/PATO_0001241 physical object quality A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities. http://purl.obolibrary.org/obo/PATO_0001241 physical object quality http://purl.obolibrary.org/obo/PATO_0000001 quality A quality which inheres in a continuant. http://purl.obolibrary.org/obo/PATO_0001404 nucleate quality http://purl.obolibrary.org/obo/PATO_0001396 cellular quality A cellular quality inhering in a bearer by virtue of bearer's number of nuclei. http://purl.obolibrary.org/obo/PATO_0001405 anucleate http://purl.obolibrary.org/obo/PATO_0001404 nucleate quality A nucleate quality inhering in a bearer by virtue of the bearer's having no nucleus. http://purl.obolibrary.org/obo/PATO_0001406 binucleate http://purl.obolibrary.org/obo/PATO_0001908 multinucleate A nucleate quality inhering in a bearer by virtue of the bearer's having two nuclei. http://purl.obolibrary.org/obo/PATO_0001407 mononucleate http://purl.obolibrary.org/obo/PATO_0002505 nucleated A nucleate quality inhering in a bearer by virtue of the bearer's having one nucleus. http://purl.obolibrary.org/obo/PATO_0001861 fasciculated http://purl.obolibrary.org/obo/PATO_0002013 fasciculation A structural quality inhering in a bearer by virtue of the bearer's forming a bundle of aligned anatomical fibers, as of muscle or nerve. http://purl.obolibrary.org/obo/PATO_0001873 cylindrical http://purl.obolibrary.org/obo/PATO_0002007 convex 3-D shape A convex 3-D shape quality inhering in a bearer by virtue of the bearer's exhibiting a consistently-sized round cross section. http://purl.obolibrary.org/obo/PATO_0001908 multinucleate http://purl.obolibrary.org/obo/PATO_0002505 nucleated A nucleate quality inhering in a bearer by virtue of the bearer's having more than one nucleus. http://purl.obolibrary.org/obo/PATO_0001992 cellularity http://purl.obolibrary.org/obo/PATO_0001995 organismal quality An organismal quality inhering in a bearer by virtue of the bearer's consisting cells. http://purl.obolibrary.org/obo/PATO_0001993 multicellular http://purl.obolibrary.org/obo/PATO_0001992 cellularity A cellularity quality inhering in a bearer by virtue of the bearer's consisting of more than one cell. http://purl.obolibrary.org/obo/PATO_0002006 2-D shape http://purl.obolibrary.org/obo/PATO_0000052 shape A shape that inheres in a 2 dimensional entity, such as a cross section or projection of a 3 dimensional entity. http://purl.obolibrary.org/obo/PATO_0002007 convex 3-D shape http://purl.obolibrary.org/obo/PATO_0002266 3-D shape A complete three dimensional shape in which for every line connecting pair of points on the object is within the object. Or: a shape lacking cavities. Contrast: concave. http://purl.obolibrary.org/obo/PATO_0002013 fasciculation http://purl.obolibrary.org/obo/PATO_0000141 structure A structural quality inhering in a bearer by virtue of whether the bearer forms a bundle of anatomical fibers, as of muscle or nerve. http://purl.obolibrary.org/obo/PATO_0002014 structure, cavities http://purl.obolibrary.org/obo/PATO_0000141 structure A structural quality that inheres in a bearer by virtue of the bearer's containing hollow areas. http://purl.obolibrary.org/obo/PATO_0002078 hollow http://purl.obolibrary.org/obo/PATO_0002014 structure, cavities A quality inhering in a bearer by virtue of the bearer's having an empty space or cavity within. http://purl.obolibrary.org/obo/PATO_0002124 laminar http://purl.obolibrary.org/obo/PATO_0000141 structure A quality inhering in a bearer by virtue of the bearer's processing the form of a thin plate sheet or layer. http://purl.obolibrary.org/obo/PATO_0002226 subcylindrical http://purl.obolibrary.org/obo/PATO_0001873 cylindrical A cylindrical shape quality inhering in a bearer by virtue of the bearer's being imperfectly cylindrical or approximately cylindrical. http://purl.obolibrary.org/obo/PATO_0002266 3-D shape http://purl.obolibrary.org/obo/PATO_0000052 shape A shape that inheres in a 3 dimensional entity. http://purl.obolibrary.org/obo/PATO_0002309 fiber shaped http://purl.obolibrary.org/obo/PATO_0002226 subcylindrical A convex 3-D shape quality inhering in a bearer by virtue of the bearer's exhibiting a by virtue of the bearer's exhibiting a consistently sized and approximately round cross-section along its length, which is many times larger than its diameter. http://purl.obolibrary.org/obo/PATO_0002318 superelliptic http://purl.obolibrary.org/obo/PATO_0002006 2-D shape A shape constituting a transition between a rectangle and a circle; a closed curve, of which the circle and ellipse are special cases, whose parametric equation is x = a.cos2/rt, y = b.cos2/rt http://purl.obolibrary.org/obo/PATO_0002505 nucleated http://purl.obolibrary.org/obo/PATO_0001404 nucleate quality A nucleate quality inhering in a bearer by virtue of the bearer's having one or more nucleus. http://purl.obolibrary.org/obo/PATO_0010000 maximally connected http://purl.obolibrary.org/obo/PATO_0000141 structure A structural quality inhering in the bearer by virtue of the bearer consisting of a single, maximally connected structure. http://purl.obolibrary.org/obo/PATO_0010001 disconnected http://purl.obolibrary.org/obo/PATO_0000141 structure A structural quality inhering in the bearer by virtue of the bearer consisting of multiple structures lacking any physical connection to each other. http://purl.obolibrary.org/obo/BFO_0000002 continuant http://purl.obolibrary.org/obo/BFO_0000001 entity An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts. http://purl.obolibrary.org/obo/BFO_0000003 occurrent http://purl.obolibrary.org/obo/BFO_0000001 entity An entity that has temporal parts and that happens, unfolds or develops through time. http://purl.obolibrary.org/obo/BFO_0000004 independent continuant http://purl.obolibrary.org/obo/BFO_0000002 continuant A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything. http://purl.obolibrary.org/obo/BFO_0000015 process http://purl.obolibrary.org/obo/BFO_0000003 occurrent An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. http://purl.obolibrary.org/obo/BFO_0000017 realizable entity http://purl.obolibrary.org/obo/BFO_0000020 specifically dependent continuant A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances. http://purl.obolibrary.org/obo/BFO_0000020 specifically dependent continuant http://purl.obolibrary.org/obo/BFO_0000002 continuant A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same. http://purl.obolibrary.org/obo/BFO_0000023 role http://purl.obolibrary.org/obo/CHEBI_50906 role A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts. http://purl.obolibrary.org/obo/BFO_0000040 material entity http://purl.obolibrary.org/obo/BFO_0000004 independent continuant An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time. http://purl.obolibrary.org/obo/PATO_0000125 mass http://purl.obolibrary.org/obo/PATO_0001018 physical quality A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter. http://purl.obolibrary.org/obo/PATO_0001396 cellular quality http://purl.obolibrary.org/obo/PATO_0070044 anatomical structure quality A monadic quality of continuant that exists at the cellular level of organisation. http://purl.obolibrary.org/obo/PATO_0001995 organismal quality http://purl.obolibrary.org/obo/PATO_0001241 physical object quality A quality that inheres in an entire organism or part of an organism. http://purl.obolibrary.org/obo/PR_000000001 protein http://purl.obolibrary.org/obo/CHEBI_36080 protein An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof. http://purl.obolibrary.org/obo/CHEBI_17968 butyrate http://purl.obolibrary.org/obo/CHEBI_78115 fatty acid anion 4:0 A short-chain fatty acid anion that is the conjugate base of butyric acid, obtained by deprotonation of the carboxy group. http://purl.obolibrary.org/obo/CHEBI_18243 dopamine http://purl.obolibrary.org/obo/CHEBI_33567 catecholamine Catechol in which the hydrogen at position 4 is substituted by a 2-aminoethyl group. http://purl.obolibrary.org/obo/CHEBI_33566 catechols http://purl.obolibrary.org/obo/CHEBI_33570 benzenediols Any compound containing an o-diphenol component. http://purl.obolibrary.org/obo/CHEBI_35757 monocarboxylic acid anion http://purl.obolibrary.org/obo/CHEBI_29067 carboxylic acid anion A carboxylic acid anion formed when the carboxy group of a monocarboxylic acid is deprotonated. http://purl.obolibrary.org/obo/CHEBI_64708 one-carbon compound http://purl.obolibrary.org/obo/CHEBI_50860 organic molecular entity An organic molecular entity containing a single carbon atom (C1). http://purl.obolibrary.org/obo/CHEBI_71666 gamma-amino acid anion http://purl.obolibrary.org/obo/CHEBI_37022 amino-acid anion An amino-acid anion in which the amino group is situated gamma- to the carboxylate group. http://purl.obolibrary.org/obo/CHEBI_75772 Saccharomyces cerevisiae metabolite http://purl.obolibrary.org/obo/CHEBI_76946 fungal metabolite Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae). http://purl.obolibrary.org/obo/CHEBI_22478 amino alcohol http://purl.obolibrary.org/obo/CHEBI_30879 alcohol An alcohol containing an amino functional group in addition to the alcohol-defining hydroxy group. http://purl.obolibrary.org/obo/CHEBI_30566 gamma-aminobutyrate http://purl.obolibrary.org/obo/CHEBI_71666 gamma-amino acid anion An gamma-amino acid anion resulting from the deprotonation of the carboxy group of gamma-aminobutyric acid. http://purl.obolibrary.org/obo/CHEBI_50047 organic amino compound http://purl.obolibrary.org/obo/CHEBI_35352 organonitrogen compound A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups. http://purl.obolibrary.org/obo/CHEBI_14321 glutamate(1-) http://purl.obolibrary.org/obo/CHEBI_33558 alpha-amino-acid anion An alpha-amino-acid anion that is the conjugate base of glutamic acid, having anionic carboxy groups and a cationic amino group http://purl.obolibrary.org/obo/CHEBI_15339 acceptor http://purl.obolibrary.org/obo/CHEBI_51086 chemical role A molecular entity that can accept an electron, a pair of electrons, an atom or a group from another molecular entity. http://purl.obolibrary.org/obo/CHEBI_15354 choline http://purl.obolibrary.org/obo/CHEBI_23217 cholines A choline that is the parent compound of the cholines class, consisting of ethanolamine having three methyl substituents attached to the amino function. http://purl.obolibrary.org/obo/CHEBI_15986 polynucleotide http://purl.obolibrary.org/obo/CHEBI_33695 information biomacromolecule A nucleobase-containing molecular entity with a polymeric structure comprised of a linear sequence of 13 or more nucleotide residues. http://purl.obolibrary.org/obo/CHEBI_16134 ammonia http://purl.obolibrary.org/obo/CHEBI_138675 gas molecular entity An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms. http://purl.obolibrary.org/obo/CHEBI_16865 gamma-aminobutyric acid http://purl.obolibrary.org/obo/CHEBI_25384 monocarboxylic acid An amino fatty acid composed of butanoic acid with the amino substituent at C-4. http://purl.obolibrary.org/obo/CHEBI_17891 donor http://purl.obolibrary.org/obo/CHEBI_51086 chemical role A molecular entity that can transfer ("donate") an electron, a pair of electrons, an atom or a group to another molecular entity. http://purl.obolibrary.org/obo/CHEBI_18237 glutamic acid http://purl.obolibrary.org/obo/CHEBI_33704 alpha-amino acid An alpha-amino acid that has formula C5H9NO4. http://purl.obolibrary.org/obo/CHEBI_18282 nucleobase http://purl.obolibrary.org/obo/CHEBI_38101 organonitrogen heterocyclic compound That part of DNA or RNA that may be involved in pairing. http://purl.obolibrary.org/obo/CHEBI_22331 alkylamines http://purl.obolibrary.org/obo/CHEBI_32952 amine Any amine formally derived from ammonia by replacing one, two or three hydrogen atoms by alkyl groups. http://purl.obolibrary.org/obo/CHEBI_23217 cholines http://purl.obolibrary.org/obo/CHEBI_35267 quaternary ammonium ion A quaternary ammonium ion based on the choline ion and its substituted derivatives thereof. http://purl.obolibrary.org/obo/CHEBI_23888 drug http://purl.obolibrary.org/obo/CHEBI_52217 pharmaceutical Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances. http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. http://purl.obolibrary.org/obo/CHEBI_24433 group http://purl.obolibrary.org/obo/CHEBI_24431 chemical entity A defined linked collection of atoms or a single atom within a molecular entity. http://purl.obolibrary.org/obo/CHEBI_24621 hormone http://purl.obolibrary.org/obo/CHEBI_33280 molecular messenger Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds. http://purl.obolibrary.org/obo/CHEBI_25990 phenylethanolamines http://purl.obolibrary.org/obo/CHEBI_23981 ethanolamines An ethanolamine compound having a phenyl (substituted or unsubstituted) group on the carbon bearing the hydroxy substituent. http://purl.obolibrary.org/obo/CHEBI_26666 short-chain fatty acid http://purl.obolibrary.org/obo/CHEBI_35366 fatty acid An aliphatic monocarboxylic acid with a chain length of less than C6. http://purl.obolibrary.org/obo/CHEBI_27207 univalent carboacyl group http://purl.obolibrary.org/obo/CHEBI_37838 carboacyl group A univalent carboacyl group is a group formed by loss of OH from the carboxy group of a carboxylic acid. http://purl.obolibrary.org/obo/CHEBI_28616 carbamic acid http://purl.obolibrary.org/obo/CHEBI_35605 carbon oxoacid A one-carbon compound that is ammonia in which one of the hydrogens is replaced by a carboxy group. Although carbamic acid derivatives are common, carbamic acid itself has never been synthesised. http://purl.obolibrary.org/obo/CHEBI_28868 fatty acid anion http://purl.obolibrary.org/obo/CHEBI_35757 monocarboxylic acid anion The conjugate base of a fatty acid, arising from deprotonation of the carboxylic acid group of the corresponding fatty acid. http://purl.obolibrary.org/obo/CHEBI_29987 glutamate(2-) http://purl.obolibrary.org/obo/CHEBI_28965 dicarboxylic acid dianion A dicarboxylic acid dianion that is the conjugate base of glutamate(1-). http://purl.obolibrary.org/obo/CHEBI_30879 alcohol http://purl.obolibrary.org/obo/CHEBI_33822 organic hydroxy compound A compound in which a hydroxy group, -OH, is attached to a saturated carbon atom. http://purl.obolibrary.org/obo/CHEBI_33249 organyl group http://purl.obolibrary.org/obo/CHEBI_51447 organic univalent group Any organic substituent group, regardless of functional type, having one free valence at a carbon atom. http://purl.obolibrary.org/obo/CHEBI_33252 atomic nucleus http://purl.obolibrary.org/obo/CHEBI_36347 nuclear particle A nucleus is the positively charged central portion of an atom, excluding the orbital electrons. http://purl.obolibrary.org/obo/CHEBI_33284 nutrient http://purl.obolibrary.org/obo/CHEBI_78295 food component A nutrient is a food component that an organism uses to survive and grow. http://purl.obolibrary.org/obo/CHEBI_33696 nucleic acid http://purl.obolibrary.org/obo/CHEBI_15986 polynucleotide A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid. http://purl.obolibrary.org/obo/CHEBI_33709 amino acid http://purl.obolibrary.org/obo/CHEBI_33575 carboxylic acid A carboxylic acid containing one or more amino groups. http://purl.obolibrary.org/obo/CHEBI_35107 azane http://purl.obolibrary.org/obo/CHEBI_35106 nitrogen hydride Saturated acyclic nitrogen hydrides having the general formula NnHn+2. http://purl.obolibrary.org/obo/CHEBI_35267 quaternary ammonium ion http://purl.obolibrary.org/obo/CHEBI_35274 ammonium ion derivative A derivative of ammonium, NH4(+), in which all four of the hydrogens bonded to nitrogen have been replaced with univalent (usually hydrocarbyl) groups. http://purl.obolibrary.org/obo/CHEBI_35522 beta-adrenergic agonist http://purl.obolibrary.org/obo/CHEBI_48540 beta-adrenergic drug An agent that selectively binds to and activates beta-adrenergic receptors. http://purl.obolibrary.org/obo/CHEBI_35524 sympathomimetic agent http://purl.obolibrary.org/obo/CHEBI_37962 adrenergic agent A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. http://purl.obolibrary.org/obo/CHEBI_35554 cardiovascular drug http://purl.obolibrary.org/obo/CHEBI_23888 drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. http://purl.obolibrary.org/obo/CHEBI_36080 protein http://purl.obolibrary.org/obo/PR_000000001 protein A biological macromolecule minimally consisting of one polypeptide chain synthesized at the ribosome. http://purl.obolibrary.org/obo/CHEBI_37527 acid http://purl.obolibrary.org/obo/CHEBI_51086 chemical role An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid). http://purl.obolibrary.org/obo/CHEBI_38324 cholinergic agonist http://purl.obolibrary.org/obo/CHEBI_38323 cholinergic drug Any drug that binds to and activates cholinergic receptors. http://purl.obolibrary.org/obo/CHEBI_50910 neurotoxin http://purl.obolibrary.org/obo/CHEBI_52209 aetiopathogenetic role A poison that interferes with the functions of the nervous system. http://purl.obolibrary.org/obo/CHEBI_51086 chemical role http://purl.obolibrary.org/obo/BFO_0000023 role A role played by the molecular entity or part thereof within a chemical context. http://purl.obolibrary.org/obo/CHEBI_58951 short-chain fatty acid anion http://purl.obolibrary.org/obo/CHEBI_28868 fatty acid anion Any fatty acid anion obtained by removal of a proton from the carboxy group of a short-chain fatty acid (chain length of less than C6). http://purl.obolibrary.org/obo/CHEBI_59202 straight-chain fatty acid http://purl.obolibrary.org/obo/CHEBI_35366 fatty acid Any fatty acid whose skeletal carbon atoms form an unbranched open chain. http://purl.obolibrary.org/obo/CHEBI_59203 straight-chain fatty acid anion http://purl.obolibrary.org/obo/CHEBI_28868 fatty acid anion A fatty acid anion formed by deprotonation of the carboxylic acid functional group of a straight-chain fatty acid. http://purl.obolibrary.org/obo/CHEBI_59740 nucleophilic reagent http://purl.obolibrary.org/obo/CHEBI_39144 Lewis base A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons. http://purl.obolibrary.org/obo/CHEBI_59814 L-alpha-amino acid anion http://purl.obolibrary.org/obo/CHEBI_33558 alpha-amino-acid anion Conjugate base of an L-alpha-amino acid arising from deprotonation of the C-1 carboxy group. http://purl.obolibrary.org/obo/CHEBI_59869 L-alpha-amino acid zwitterion http://purl.obolibrary.org/obo/CHEBI_78608 alpha-amino acid zwitterion Zwitterionic form of an L-alpha-amino acid having an anionic carboxy group and a protonated amino group. http://purl.obolibrary.org/obo/CHEBI_60242 monovalent inorganic cation http://purl.obolibrary.org/obo/CHEBI_36915 inorganic cation An atom or small molecule with a positive charge that does not contain carbon in covalent linkage, with a valency of one. http://purl.obolibrary.org/obo/CHEBI_60466 peptide zwitterion http://purl.obolibrary.org/obo/CHEBI_27369 zwitterion Zwitterionic form of any peptide where, in general, the amino terminus is positively charged and the carboxy terminus is negatively charged. http://purl.obolibrary.org/obo/CHEBI_72695 organic molecule http://purl.obolibrary.org/obo/CHEBI_50860 organic molecular entity Any molecule that consists of at least one carbon atom as part of the electrically neutral entity. http://purl.obolibrary.org/obo/CHEBI_76807 EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76764 EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor An EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor that interferes with the action of any non-peptide linear amide C-N hydrolase (EC 3.5.1.*). http://purl.obolibrary.org/obo/CHEBI_77941 EC 3.5.1.4 (amidase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76807 EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of amidase (EC 3.5.1.4). http://purl.obolibrary.org/obo/CHEBI_78675 fundamental metabolite http://purl.obolibrary.org/obo/CHEBI_25212 metabolite Any metabolite produced by all living cells. http://purl.obolibrary.org/obo/CHEBI_79388 divalent inorganic anion http://purl.obolibrary.org/obo/CHEBI_24834 inorganic anion Any inorganic anion with a valency of two. http://purl.obolibrary.org/obo/CHEBI_29340 hydridonitrate(2-) http://purl.obolibrary.org/obo/CHEBI_35106 nitrogen hydride A divalent inorganic anion resulting from the removal of two protons from ammonia. http://purl.obolibrary.org/obo/CHEBI_33246 inorganic group http://purl.obolibrary.org/obo/CHEBI_24433 group Any substituent group which does not contain carbon. http://purl.obolibrary.org/obo/CHEBI_33702 polyatomic cation http://purl.obolibrary.org/obo/CHEBI_36916 cation A cation consisting of more than one atom. http://purl.obolibrary.org/obo/CHEBI_350546 serotonin(1+) http://purl.obolibrary.org/obo/CHEBI_35274 ammonium ion derivative An ammonium ion that is the conjugate acid of serotonin; major species at pH 7.3. http://purl.obolibrary.org/obo/CHEBI_37886 adrenergic agonist http://purl.obolibrary.org/obo/CHEBI_37962 adrenergic agent An agent that selectively binds to and activates adrenergic receptors. http://purl.obolibrary.org/obo/CHEBI_38716 carboxylic acid dianion http://purl.obolibrary.org/obo/CHEBI_29067 carboxylic acid anion Any dianion containing at least one carboxy group. http://purl.obolibrary.org/obo/CHEBI_50313 onium cation http://purl.obolibrary.org/obo/CHEBI_50312 onium compound Mononuclear cations derived by addition of a hydron to a mononuclear parent hydride of the pnictogen, chalcogen and halogen families. http://purl.obolibrary.org/obo/CHEBI_62031 polar amino acid zwitterion http://purl.obolibrary.org/obo/CHEBI_35238 amino acid zwitterion Zwitterionic form of a polar amino acid having an anionic carboxy group and a protonated amino group. http://purl.obolibrary.org/obo/CHEBI_60690 nitrogen-containing fatty acid http://purl.obolibrary.org/obo/CHEBI_35366 fatty acid Any fatty acid containing nitrogen as either a substituent or a replacement for a methylene carbon. http://purl.obolibrary.org/obo/CHEBI_61007 amino fatty acid anion http://purl.obolibrary.org/obo/CHEBI_37022 amino-acid anion A nitrogen-containing fatty acid anion arising from deprotonation of the carboxy group of any amino fatty acid. http://purl.obolibrary.org/obo/CHEBI_76759 EC 3.* (hydrolase) inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any enzyme inhibitor that interferes with the action of a hydrolase (EC 3.*.*.*). http://purl.obolibrary.org/obo/CHEBI_131604 Mycoplasma genitalium metabolite http://purl.obolibrary.org/obo/CHEBI_76969 bacterial metabolite Any bacterial metabolite produced during a metabolic reaction in Mycoplasma genitalium. http://purl.obolibrary.org/obo/CHEBI_15705 L-alpha-amino acid http://purl.obolibrary.org/obo/CHEBI_33704 alpha-amino acid Any alpha-amino acid having L-configuration at the alpha-carbon. http://purl.obolibrary.org/obo/CHEBI_16670 peptide http://purl.obolibrary.org/obo/CHEBI_37622 carboxamide Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. http://purl.obolibrary.org/obo/CHEBI_22315 alkaloid http://purl.obolibrary.org/obo/CHEBI_35352 organonitrogen compound Any of the naturally occurring, basic nitrogen compounds (mostly heterocyclic) occurring mostly in the plant kingdom, but also found in bacteria, fungi, and animals. By extension, certain neutral compounds biogenetically related to basic alkaloids are also classed as alkaloids. Amino acids, peptides, proteins, nucleotides, nucleic acids, amino sugars and antibiotics are not normally regarded as alkaloids. Compounds in which the nitrogen is exocyclic (dopamine, mescaline, serotonin, etc.) are usually classed as amines rather than alkaloids. http://purl.obolibrary.org/obo/CHEBI_24780 imidazoles http://purl.obolibrary.org/obo/CHEBI_23677 diazole A five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton. http://purl.obolibrary.org/obo/CHEBI_24828 indoles http://purl.obolibrary.org/obo/CHEBI_22728 benzopyrrole Any compound containing an indole skeleton. http://purl.obolibrary.org/obo/CHEBI_25212 metabolite http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. http://purl.obolibrary.org/obo/CHEBI_25384 monocarboxylic acid http://purl.obolibrary.org/obo/CHEBI_33575 carboxylic acid An oxoacid containing a single carboxy group. http://purl.obolibrary.org/obo/CHEBI_25697 organic cation http://purl.obolibrary.org/obo/CHEBI_36916 cation Any organic ion with a net positive charge. http://purl.obolibrary.org/obo/CHEBI_27162 tryptamines http://purl.obolibrary.org/obo/CHEBI_24828 indoles Tryptamine and its substitution derivatives. http://purl.obolibrary.org/obo/CHEBI_32877 primary amine http://purl.obolibrary.org/obo/CHEBI_50994 primary amino compound A compound formally derived from ammonia by replacing one hydrogen atom by a hydrocarbyl group. http://purl.obolibrary.org/obo/CHEBI_33281 antimicrobial agent http://purl.obolibrary.org/obo/CHEBI_24432 biological role A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. http://purl.obolibrary.org/obo/CHEBI_33308 carboxylic ester http://purl.obolibrary.org/obo/CHEBI_35701 ester An ester of a carboxylic acid. http://purl.obolibrary.org/obo/CHEBI_33558 alpha-amino-acid anion http://purl.obolibrary.org/obo/CHEBI_37022 amino-acid anion An amino-acid anion obtained by deprotonation of any alpha-amino acid. http://purl.obolibrary.org/obo/CHEBI_33575 carboxylic acid http://purl.obolibrary.org/obo/CHEBI_35605 carbon oxoacid An oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid. http://purl.obolibrary.org/obo/CHEBI_33704 alpha-amino acid http://purl.obolibrary.org/obo/CHEBI_33709 amino acid An amino acid in which the amino group is located on the carbon atom at the position alpha to the carboxy group. http://purl.obolibrary.org/obo/CHEBI_33833 heteroarene http://purl.obolibrary.org/obo/CHEBI_33659 organic aromatic compound A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2). http://purl.obolibrary.org/obo/CHEBI_33853 phenols http://purl.obolibrary.org/obo/CHEBI_33659 organic aromatic compound Compounds having one or more hydroxy groups attached to a benzene or other arene ring. http://purl.obolibrary.org/obo/CHEBI_35274 ammonium ion derivative http://purl.obolibrary.org/obo/CHEBI_33702 polyatomic cation A derivative of ammonium, NH4(+), in which one (or more) of the hydrogens bonded to the nitrogen have been replaced with univalent organyl groups. The substituting carbon of the organyl group must not itself be directly attached to a heteroatom (thereby excluding protonated amides, hemiaminals, etc). http://purl.obolibrary.org/obo/CHEBI_35352 organonitrogen compound http://purl.obolibrary.org/obo/CHEBI_51143 nitrogen molecular entity Any heteroorganic entity containing at least one carbon-nitrogen bond. http://purl.obolibrary.org/obo/CHEBI_35366 fatty acid http://purl.obolibrary.org/obo/CHEBI_25384 monocarboxylic acid Any aliphatic monocarboxylic acid derived from or contained in esterified form in an animal or vegetable fat, oil or wax. Natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated. By extension, the term is sometimes used to embrace all acyclic aliphatic carboxylic acids. http://purl.obolibrary.org/obo/CHEBI_35620 vasodilator agent http://purl.obolibrary.org/obo/CHEBI_35554 cardiovascular drug A drug used to cause dilation of the blood vessels. http://purl.obolibrary.org/obo/CHEBI_36586 carbonyl compound http://purl.obolibrary.org/obo/CHEBI_36963 organooxygen compound Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives. http://purl.obolibrary.org/obo/CHEBI_36963 organooxygen compound http://purl.obolibrary.org/obo/CHEBI_36962 organochalcogen compound An organochalcogen compound containing at least one carbon-oxygen bond. http://purl.obolibrary.org/obo/CHEBI_37622 carboxamide http://purl.obolibrary.org/obo/CHEBI_33256 primary amide An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom. http://purl.obolibrary.org/obo/CHEBI_38325 muscarinic agonist http://purl.obolibrary.org/obo/CHEBI_38324 cholinergic agonist Any drug that binds to and activates a muscarinic cholinergic receptor. http://purl.obolibrary.org/obo/CHEBI_38958 indole alkaloid http://purl.obolibrary.org/obo/CHEBI_22315 alkaloid An alkaloid containing an indole skeleton. http://purl.obolibrary.org/obo/CHEBI_50860 organic molecular entity http://purl.obolibrary.org/obo/CHEBI_33582 carbon group molecular entity Any molecular entity that contains carbon. http://purl.obolibrary.org/obo/CHEBI_75767 animal metabolite http://purl.obolibrary.org/obo/CHEBI_75763 eukaryotic metabolite Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals. http://purl.obolibrary.org/obo/CHEBI_75771 mouse metabolite http://purl.obolibrary.org/obo/CHEBI_75768 mammalian metabolite Any mammalian metabolite produced during a metabolic reaction in a mouse (Mus musculus). http://purl.obolibrary.org/obo/CHEBI_76924 plant metabolite http://purl.obolibrary.org/obo/CHEBI_75763 eukaryotic metabolite Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. http://purl.obolibrary.org/obo/CHEBI_76946 fungal metabolite http://purl.obolibrary.org/obo/CHEBI_75763 eukaryotic metabolite Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds. http://purl.obolibrary.org/obo/CHEBI_76971 Escherichia coli metabolite http://purl.obolibrary.org/obo/CHEBI_76969 bacterial metabolite Any bacterial metabolite produced during a metabolic reaction in Escherichia coli. http://purl.obolibrary.org/obo/CHEBI_17134 octopamine http://purl.obolibrary.org/obo/CHEBI_27175 tyramines A member of the class of phenylethanolamines that is phenol which is substituted at the para- position by a 2-amino-1-hydroxyethyl group. A biogenic phenylethanolamine which has been found to act as a neurotransmitter, neurohormone or neuromodulator in invertebrates. http://purl.obolibrary.org/obo/CHEBI_30772 butyric acid http://purl.obolibrary.org/obo/CHEBI_140601 fatty acid 4:0 A straight-chain saturated fatty acid that is butane in which one of the terminal methyl groups has been oxidised to a carboxy group. http://purl.obolibrary.org/obo/CHEBI_33655 aromatic compound http://purl.obolibrary.org/obo/CHEBI_33595 cyclic compound A cyclically conjugated molecular entity with a stability (due to delocalization) significantly greater than that of a hypothetical localized structure (e.g. Kekule structure) is said to possess aromatic character. http://purl.obolibrary.org/obo/CHEBI_35692 dicarboxylic acid http://purl.obolibrary.org/obo/CHEBI_33575 carboxylic acid Any carboxylic acid containing two carboxy groups. http://purl.obolibrary.org/obo/CHEBI_50994 primary amino compound http://purl.obolibrary.org/obo/CHEBI_50047 organic amino compound A compound formally derived from ammonia by replacing one hydrogen atom by an organyl group. http://purl.obolibrary.org/obo/CHEBI_65256 antimicrobial food preservative http://purl.obolibrary.org/obo/CHEBI_33281 antimicrobial agent A food preservative which prevents decomposition of food by preventing the growth of fungi or bacteria. In European countries, E-numbers for permitted food preservatives are from E200 to E299, divided into sorbates (E200-209), benzoates (E210-219), sulfites (E220-229), phenols and formates (E230-239), nitrates (E240-259), acetates (E260-269), lactates (E270-279), propionates (E280-289) and others (E290-299). http://purl.obolibrary.org/obo/CHEBI_75763 eukaryotic metabolite http://purl.obolibrary.org/obo/CHEBI_25212 metabolite Any metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms. http://purl.obolibrary.org/obo/CHEBI_76969 bacterial metabolite http://purl.obolibrary.org/obo/CHEBI_75787 prokaryotic metabolite Any prokaryotic metabolite produced during a metabolic reaction in bacteria. http://purl.obolibrary.org/obo/CHEBI_35287 acylcholine http://purl.obolibrary.org/obo/CHEBI_35267 quaternary ammonium ion A choline ester formed from choline and a carboxylic acid. http://purl.obolibrary.org/obo/CHEBI_15355 acetylcholine http://purl.obolibrary.org/obo/CHEBI_35287 acylcholine Actylcholine is an ester of acetic acid and choline, which acts as a neurotransmitter. http://purl.obolibrary.org/obo/CHEBI_28790 serotonin http://purl.obolibrary.org/obo/CHEBI_25375 monoamine molecular messenger The 5-hydroxy derivative of tryptamine. http://purl.obolibrary.org/obo/CHEBI_61115 EC 3.5.1.98 (histone deacetylase) inhibitor http://purl.obolibrary.org/obo/CHEBI_76807 EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98). http://purl.obolibrary.org/obo/CHEBI_16541 protein polypeptide chain http://purl.obolibrary.org/obo/CHEBI_15841 polypeptide A naturally occurring polypeptide synthesized at the ribosome. http://purl.obolibrary.org/obo/CHEBI_24318 glutamine family amino acid http://purl.obolibrary.org/obo/CHEBI_83813 proteinogenic amino acid An L-alpha-amino acid which is L-glutamic acid or any of the essential amino acids biosynthesised from it (glutamine, proline and arginine). A closed class. http://purl.obolibrary.org/obo/CHEBI_25375 monoamine molecular messenger http://purl.obolibrary.org/obo/CHEBI_63534 monoamine A group of neurotransmitters and neuromodulators that contain one amino group that is connected to an aromatic ring by ethylene group (-CH2-CH2-). Monoamines are derived from the aromatic amino acids phenylalanine, tyrosine, histidine and tryptophan. http://purl.obolibrary.org/obo/CHEBI_27175 tyramines http://purl.obolibrary.org/obo/CHEBI_64365 aralkylamino compound Aralkylamino compounds which contain a tyramine skeleton. http://purl.obolibrary.org/obo/CHEBI_28938 ammonium http://purl.obolibrary.org/obo/CHEBI_50313 onium cation An onium cation obtained by protonation of ammonia. http://purl.obolibrary.org/obo/CHEBI_33256 primary amide http://purl.obolibrary.org/obo/CHEBI_32988 amide A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group. http://purl.obolibrary.org/obo/CHEBI_33839 macromolecule http://purl.obolibrary.org/obo/CHEBI_36357 polyatomic entity A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. http://purl.obolibrary.org/obo/CHEBI_35701 ester http://purl.obolibrary.org/obo/CHEBI_36963 organooxygen compound A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter. http://purl.obolibrary.org/obo/CHEBI_37962 adrenergic agent http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter. http://purl.obolibrary.org/obo/CHEBI_39418 straight-chain saturated fatty acid http://purl.obolibrary.org/obo/CHEBI_59202 straight-chain fatty acid Any saturated fatty acid lacking a carbon side-chain. http://purl.obolibrary.org/obo/CHEBI_46787 solvent http://purl.obolibrary.org/obo/CHEBI_51086 chemical role A liquid that can dissolve other substances (solutes) without any change in their chemical composition. http://purl.obolibrary.org/obo/CHEBI_48354 polar solvent http://purl.obolibrary.org/obo/CHEBI_46787 solvent A solvent that is composed of polar molecules. Polar solvents can dissolve ionic compounds or ionisable covalent compounds. http://purl.obolibrary.org/obo/CHEBI_48560 dopaminergic agent http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons. http://purl.obolibrary.org/obo/CHEBI_57887 tryptaminium http://purl.obolibrary.org/obo/CHEBI_65296 primary ammonium ion An ammonium ion that is the conjugate acid of tryptamine arising from protonation of the primary amino group; major species at pH 7.3. http://purl.obolibrary.org/obo/CHEBI_58025 octopaminium http://purl.obolibrary.org/obo/CHEBI_35274 ammonium ion derivative The conjugate acid of octopamine; major species at pH 7.3. http://purl.obolibrary.org/obo/CHEBI_58954 straight-chain saturated fatty acid anion http://purl.obolibrary.org/obo/CHEBI_58953 saturated fatty acid anion Any saturated fatty acid anion lacking a carbon side-chain. http://purl.obolibrary.org/obo/CHEBI_59888 gamma-aminobutyric acid zwitterion http://purl.obolibrary.org/obo/CHEBI_35238 amino acid zwitterion Zwitterionic form of gamma-aminobutyric acid having an anionic carboxy group and a protonated amino group. http://purl.obolibrary.org/obo/CHEBI_64365 aralkylamino compound http://purl.obolibrary.org/obo/CHEBI_50047 organic amino compound An organic amino compound in which an aminoalkyl group is linked to an arene. http://purl.obolibrary.org/obo/CHEBI_78295 food component http://purl.obolibrary.org/obo/CHEBI_52211 physiological role A physiological role played by any substance that is distributed in foodstuffs. It includes materials derived from plants or animals, such as vitamins or minerals, as well as environmental contaminants. http://purl.obolibrary.org/obo/CHEBI_78433 refrigerant http://purl.obolibrary.org/obo/CHEBI_33232 application A substance used in a thermodynamic heat pump cycle or refrigeration cycle that undergoes a phase change from a gas to a liquid and back. Refrigerants are used in air-conditioning systems and freezers or refrigerators and are assigned a "R" number (by ASHRAE - formerly the American Society of Heating, Refrigerating and Air Conditioning Engineers), which is determined systematically according to their molecular structure. http://purl.obolibrary.org/obo/CHEBI_79389 monovalent inorganic anion http://purl.obolibrary.org/obo/CHEBI_24834 inorganic anion Any inorganic anion with a valency of one. http://purl.obolibrary.org/obo/CHEBI_83813 proteinogenic amino acid http://purl.obolibrary.org/obo/CHEBI_35352 organonitrogen compound Any of the 23 alpha-amino acids that are precursors to proteins, and are incorporated into proteins during translation. The group includes the 20 amino acids encoded by the nuclear genes of eukaryotes together with selenocysteine, pyrrolysine, and N-formylmethionine. Apart from glycine, which is non-chiral, all have L configuration. http://purl.obolibrary.org/obo/CHEBI_22695 base http://purl.obolibrary.org/obo/CHEBI_51086 chemical role A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base). http://purl.obolibrary.org/obo/CHEBI_33694 biomacromolecule http://purl.obolibrary.org/obo/CHEBI_33839 macromolecule A macromolecule formed by a living organism. http://purl.obolibrary.org/obo/CHEBI_33697 ribonucleic acid http://purl.obolibrary.org/obo/CHEBI_33696 nucleic acid High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins. http://purl.obolibrary.org/obo/CHEBI_38147 cardiotonic drug http://purl.obolibrary.org/obo/CHEBI_35554 cardiovascular drug A drug that has a strengthening effect on the heart or that can increase cardiac output. http://purl.obolibrary.org/obo/CHEBI_58432 histaminium http://purl.obolibrary.org/obo/CHEBI_35274 ammonium ion derivative An ammonium ion that is the conjugate acid of histamine protonated on the side-chain nitrogen. http://purl.obolibrary.org/obo/CHEBI_59905 dopaminium(1+) http://purl.obolibrary.org/obo/CHEBI_35274 ammonium ion derivative An ammonium ion that is the conjugate acid of dopamine; major species at pH 7.3. http://purl.obolibrary.org/obo/CHEBI_78115 fatty acid anion 4:0 http://purl.obolibrary.org/obo/CHEBI_58951 short-chain fatty acid anion Any saturated fatty acid anion containing 4 carbons. Formed by deprotonation of the carboxylic acid moiety. Major species at pH 7.3. http://purl.obolibrary.org/obo/CHEBI_33233 fundamental particle http://purl.obolibrary.org/obo/CHEBI_36342 subatomic particle A particle not known to have substructure. http://purl.obolibrary.org/obo/CHEBI_33273 polyatomic anion http://purl.obolibrary.org/obo/CHEBI_36358 polyatomic ion An anion consisting of more than one atom. http://purl.obolibrary.org/obo/CHEBI_33579 main group molecular entity http://purl.obolibrary.org/obo/CHEBI_23367 molecular entity A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table. http://purl.obolibrary.org/obo/CHEBI_33595 cyclic compound http://purl.obolibrary.org/obo/CHEBI_25367 molecule Any molecule that consists of a series of atoms joined together to form a ring. http://purl.obolibrary.org/obo/CHEBI_33636 bicyclic compound http://purl.obolibrary.org/obo/CHEBI_33595 cyclic compound A molecule that features two fused rings. http://purl.obolibrary.org/obo/CHEBI_33671 heteropolycyclic compound http://purl.obolibrary.org/obo/CHEBI_33635 polycyclic compound A polycyclic compound in which at least one of the rings contains at least one non-carbon atom. http://purl.obolibrary.org/obo/CHEBI_33674 s-block molecular entity http://purl.obolibrary.org/obo/CHEBI_33579 main group molecular entity An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element. http://purl.obolibrary.org/obo/CHEBI_33692 hydrides http://purl.obolibrary.org/obo/CHEBI_37577 heteroatomic molecular entity Hydrides are chemical compounds of hydrogen with other chemical elements. http://purl.obolibrary.org/obo/CHEBI_36339 baryon http://purl.obolibrary.org/obo/CHEBI_36344 hadron Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy). http://purl.obolibrary.org/obo/CHEBI_36347 nuclear particle http://purl.obolibrary.org/obo/CHEBI_36342 subatomic particle A nucleus or any of its constituents in any of their energy states. http://purl.obolibrary.org/obo/CHEBI_64709 organic acid http://purl.obolibrary.org/obo/CHEBI_50860 organic molecular entity Any organic molecular entity that is acidic and contains carbon in covalent linkage. http://purl.obolibrary.org/obo/CHEBI_52845 cyclic organic group http://purl.obolibrary.org/obo/CHEBI_33247 organic group An organic group that consists of a closed ring. It may be a substituent or a skeleton. http://purl.obolibrary.org/obo/GO_0004857 enzyme inhibitor activity http://purl.obolibrary.org/obo/GO_0140678 molecular function inhibitor activity Binds to and stops, prevents or reduces the activity of an enzyme. http://purl.obolibrary.org/obo/GO_0005504 fatty acid binding http://purl.obolibrary.org/obo/GO_0033293 monocarboxylic acid binding Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. http://purl.obolibrary.org/obo/GO_0005575 cellular_component http://purl.obolibrary.org/obo/BFO_0000040 material entity A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome). http://purl.obolibrary.org/obo/GO_0005635 nuclear envelope http://purl.obolibrary.org/obo/GO_0031967 organelle envelope The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). http://purl.obolibrary.org/obo/GO_0005938 cell cortex http://purl.obolibrary.org/obo/GO_0005737 cytoplasm The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins. http://purl.obolibrary.org/obo/GO_0006066 alcohol metabolic process http://purl.obolibrary.org/obo/GO_1901615 organic hydroxy compound metabolic process The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. http://purl.obolibrary.org/obo/GO_0006082 organic acid metabolic process http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage. http://purl.obolibrary.org/obo/GO_0006083 acetate metabolic process http://purl.obolibrary.org/obo/GO_0032787 monocarboxylic acid metabolic process The chemical reactions and pathways involving acetate, the anion of acetic acid. http://purl.obolibrary.org/obo/GO_0006139 nucleobase-containing compound metabolic process http://purl.obolibrary.org/obo/GO_1901360 organic cyclic compound metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. http://purl.obolibrary.org/obo/GO_0006518 peptide metabolic process http://purl.obolibrary.org/obo/GO_1901564 organonitrogen compound metabolic process The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. http://purl.obolibrary.org/obo/GO_0006536 glutamate metabolic process http://purl.obolibrary.org/obo/GO_0009064 glutamine family amino acid metabolic process The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid. http://purl.obolibrary.org/obo/GO_0006537 glutamate biosynthetic process http://purl.obolibrary.org/obo/GO_0008652 amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. http://purl.obolibrary.org/obo/GO_0006584 catecholamine metabolic process http://purl.obolibrary.org/obo/GO_0006576 biogenic amine metabolic process The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. http://purl.obolibrary.org/obo/GO_0006586 indolalkylamine metabolic process http://purl.obolibrary.org/obo/GO_0006576 biogenic amine metabolic process The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. http://purl.obolibrary.org/obo/GO_0006589 octopamine biosynthetic process http://purl.obolibrary.org/obo/GO_0042401 biogenic amine biosynthetic process The chemical reactions and pathways resulting in the formation of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species. http://purl.obolibrary.org/obo/GO_0006629 lipid metabolic process http://purl.obolibrary.org/obo/GO_0071704 organic substance metabolic process The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. http://purl.obolibrary.org/obo/GO_0006725 cellular aromatic compound metabolic process http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. http://purl.obolibrary.org/obo/GO_0006807 nitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_0008152 metabolic process The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. http://purl.obolibrary.org/obo/GO_0006996 organelle organization http://purl.obolibrary.org/obo/GO_0016043 cellular component organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. http://purl.obolibrary.org/obo/GO_0006998 nuclear envelope organization http://purl.obolibrary.org/obo/GO_0061024 membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope. http://purl.obolibrary.org/obo/GO_0007028 cytoplasm organization http://purl.obolibrary.org/obo/GO_0016043 cellular component organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. http://purl.obolibrary.org/obo/GO_0008152 metabolic process http://purl.obolibrary.org/obo/GO_0008150 biological_process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. http://purl.obolibrary.org/obo/GO_0008291 acetylcholine metabolic process http://purl.obolibrary.org/obo/GO_1900619 acetate ester metabolic process The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues. http://purl.obolibrary.org/obo/GO_0008610 lipid biosynthetic process http://purl.obolibrary.org/obo/GO_1901576 organic substance biosynthetic process The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. http://purl.obolibrary.org/obo/GO_0009084 glutamine family amino acid biosynthetic process http://purl.obolibrary.org/obo/GO_0016053 organic acid biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. http://purl.obolibrary.org/obo/GO_0009112 nucleobase metabolic process http://purl.obolibrary.org/obo/GO_1901564 organonitrogen compound metabolic process The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine. http://purl.obolibrary.org/obo/GO_0009712 catechol-containing compound metabolic process http://purl.obolibrary.org/obo/GO_0018958 phenol-containing compound metabolic process The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent. http://purl.obolibrary.org/obo/GO_0009820 alkaloid metabolic process http://purl.obolibrary.org/obo/GO_1901564 organonitrogen compound metabolic process The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases). http://purl.obolibrary.org/obo/GO_0010256 endomembrane system organization http://purl.obolibrary.org/obo/GO_0016043 cellular component organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system. http://purl.obolibrary.org/obo/GO_0012505 endomembrane system http://purl.obolibrary.org/obo/GO_0110165 cellular anatomical entity A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles. http://purl.obolibrary.org/obo/GO_0016020 membrane http://purl.obolibrary.org/obo/GO_0110165 cellular anatomical entity A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. http://purl.obolibrary.org/obo/GO_0016043 cellular component organization http://purl.obolibrary.org/obo/GO_0071840 cellular component organization or biogenesis A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. http://purl.obolibrary.org/obo/GO_0016595 glutamate binding http://purl.obolibrary.org/obo/GO_0031406 carboxylic acid binding Binding to glutamate, the anion of 2-aminopentanedioic acid. http://purl.obolibrary.org/obo/GO_0018958 phenol-containing compound metabolic process http://purl.obolibrary.org/obo/GO_1901360 organic cyclic compound metabolic process The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. http://purl.obolibrary.org/obo/GO_0019210 kinase inhibitor activity http://purl.obolibrary.org/obo/GO_0019207 kinase regulator activity Binds to and stops, prevents or reduces the activity of a kinase. http://purl.obolibrary.org/obo/GO_0019538 protein metabolic process http://purl.obolibrary.org/obo/GO_1901564 organonitrogen compound metabolic process The chemical reactions and pathways involving a protein. Includes protein modification. http://purl.obolibrary.org/obo/GO_0019748 secondary metabolic process http://purl.obolibrary.org/obo/GO_0008152 metabolic process The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients. http://purl.obolibrary.org/obo/GO_0019751 polyol metabolic process http://purl.obolibrary.org/obo/GO_0006066 alcohol metabolic process The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. http://purl.obolibrary.org/obo/GO_0019752 carboxylic acid metabolic process http://purl.obolibrary.org/obo/GO_0043436 oxoacid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). http://purl.obolibrary.org/obo/GO_0022411 cellular component disassembly http://purl.obolibrary.org/obo/GO_0016043 cellular component organization A cellular process that results in the breakdown of a cellular component. http://purl.obolibrary.org/obo/GO_0030234 enzyme regulator activity http://purl.obolibrary.org/obo/GO_0098772 molecular function regulator activity Binds to and modulates the activity of an enzyme. http://purl.obolibrary.org/obo/GO_0031406 carboxylic acid binding http://purl.obolibrary.org/obo/GO_0043168 anion binding Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-). http://purl.obolibrary.org/obo/GO_0031965 nuclear membrane http://purl.obolibrary.org/obo/GO_0031090 organelle membrane Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. http://purl.obolibrary.org/obo/GO_0031967 organelle envelope http://purl.obolibrary.org/obo/GO_0031975 envelope A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes. http://purl.obolibrary.org/obo/GO_0032787 monocarboxylic acid metabolic process http://purl.obolibrary.org/obo/GO_0019752 carboxylic acid metabolic process The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-). http://purl.obolibrary.org/obo/GO_0033218 amide binding http://purl.obolibrary.org/obo/GO_0005488 binding Binding to an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. http://purl.obolibrary.org/obo/GO_0034311 diol metabolic process http://purl.obolibrary.org/obo/GO_0019751 polyol metabolic process The chemical reactions and pathways involving a diol, a compound that contains two hydroxy groups, generally assumed to be, but not necessarily, alcoholic. http://purl.obolibrary.org/obo/GO_0034641 cellular nitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells. http://purl.obolibrary.org/obo/GO_0035240 dopamine binding http://purl.obolibrary.org/obo/GO_0043169 cation binding Binding to dopamine, a catecholamine neurotransmitter formed by aromatic-L-amino-acid decarboxylase from 3,4-dihydroxy-L-phenylalanine. http://purl.obolibrary.org/obo/GO_0042136 neurotransmitter biosynthetic process http://purl.obolibrary.org/obo/GO_0042133 neurotransmitter metabolic process The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. http://purl.obolibrary.org/obo/GO_0042416 dopamine biosynthetic process http://purl.obolibrary.org/obo/GO_0042417 dopamine metabolic process The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. http://purl.obolibrary.org/obo/GO_0042427 serotonin biosynthetic process http://purl.obolibrary.org/obo/GO_0042428 serotonin metabolic process The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. http://purl.obolibrary.org/obo/GO_0042430 indole-containing compound metabolic process http://purl.obolibrary.org/obo/GO_1901564 organonitrogen compound metabolic process The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton. http://purl.obolibrary.org/obo/GO_0042439 ethanolamine-containing compound metabolic process http://purl.obolibrary.org/obo/GO_0006576 biogenic amine metabolic process The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived from it. http://purl.obolibrary.org/obo/GO_0043021 ribonucleoprotein complex binding http://purl.obolibrary.org/obo/GO_0044877 protein-containing complex binding Binding to a complex of RNA and protein. http://purl.obolibrary.org/obo/GO_0043170 macromolecule metabolic process http://purl.obolibrary.org/obo/GO_0071704 organic substance metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. http://purl.obolibrary.org/obo/GO_0043176 amine binding http://purl.obolibrary.org/obo/GO_0005488 binding Binding to an amine, a weakly basic organic compound that contains an amino or a substituted amino group. http://purl.obolibrary.org/obo/GO_0043231 intracellular membrane-bounded organelle http://purl.obolibrary.org/obo/GO_0043229 intracellular organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. http://purl.obolibrary.org/obo/GO_0043648 dicarboxylic acid metabolic process http://purl.obolibrary.org/obo/GO_0019752 carboxylic acid metabolic process The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-). http://purl.obolibrary.org/obo/GO_0043650 dicarboxylic acid biosynthetic process http://purl.obolibrary.org/obo/GO_0046394 carboxylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups. http://purl.obolibrary.org/obo/GO_0044238 primary metabolic process http://purl.obolibrary.org/obo/GO_0008152 metabolic process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. http://purl.obolibrary.org/obo/GO_0044249 cellular biosynthetic process http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. http://purl.obolibrary.org/obo/GO_0044255 cellular lipid metabolic process http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process The chemical reactions and pathways involving lipids, as carried out by individual cells. http://purl.obolibrary.org/obo/GO_0044281 small molecule metabolic process http://purl.obolibrary.org/obo/GO_0008152 metabolic process The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. http://purl.obolibrary.org/obo/GO_0044550 secondary metabolite biosynthetic process http://purl.obolibrary.org/obo/GO_0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. http://purl.obolibrary.org/obo/GO_0046173 polyol biosynthetic process http://purl.obolibrary.org/obo/GO_0046165 alcohol biosynthetic process The chemical reactions and pathways resulting in the formation of a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms. http://purl.obolibrary.org/obo/GO_0046189 phenol-containing compound biosynthetic process http://purl.obolibrary.org/obo/GO_1901362 organic cyclic compound biosynthetic process The chemical reactions and pathways resulting in the formation of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring. http://purl.obolibrary.org/obo/GO_0046333 octopamine metabolic process http://purl.obolibrary.org/obo/GO_0042133 neurotransmitter metabolic process The chemical reactions and pathways involving octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species. http://purl.obolibrary.org/obo/GO_0051081 nuclear membrane disassembly http://purl.obolibrary.org/obo/GO_0030397 membrane disassembly The controlled breakdown of the nuclear membranes, for example during cellular division. http://purl.obolibrary.org/obo/GO_0051378 serotonin binding http://purl.obolibrary.org/obo/GO_0043169 cation binding Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. http://purl.obolibrary.org/obo/GO_0051381 histamine binding http://purl.obolibrary.org/obo/GO_0043169 cation binding Binding to histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. http://purl.obolibrary.org/obo/GO_0055086 nucleobase-containing small molecule metabolic process http://purl.obolibrary.org/obo/GO_0044281 small molecule metabolic process The cellular chemical reactions and pathways involving a nucleobase-containing small molecule: a nucleobase, a nucleoside, or a nucleotide. http://purl.obolibrary.org/obo/GO_0061024 membrane organization http://purl.obolibrary.org/obo/GO_0016043 cellular component organization A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. http://purl.obolibrary.org/obo/GO_0065003 protein-containing complex assembly http://purl.obolibrary.org/obo/GO_0043933 protein-containing complex organization The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. http://purl.obolibrary.org/obo/GO_0071704 organic substance metabolic process http://purl.obolibrary.org/obo/GO_0008152 metabolic process The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. http://purl.obolibrary.org/obo/GO_0071944 cell periphery http://purl.obolibrary.org/obo/GO_0110165 cellular anatomical entity The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures. http://purl.obolibrary.org/obo/GO_0090304 nucleic acid metabolic process http://purl.obolibrary.org/obo/GO_0043170 macromolecule metabolic process Any cellular metabolic process involving nucleic acids. http://purl.obolibrary.org/obo/GO_0098772 molecular function regulator activity http://purl.obolibrary.org/obo/GO_0003674 molecular_function A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition. http://purl.obolibrary.org/obo/GO_0099568 cytoplasmic region http://purl.obolibrary.org/obo/GO_0005737 cytoplasm Any (proper) part of the cytoplasm of a single cell of sufficient size to still be considered cytoplasm. http://purl.obolibrary.org/obo/GO_1901160 primary amino compound metabolic process http://purl.obolibrary.org/obo/GO_1901564 organonitrogen compound metabolic process The chemical reactions and pathways involving primary amino compound. http://purl.obolibrary.org/obo/GO_1901576 organic substance biosynthetic process http://purl.obolibrary.org/obo/GO_0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon. http://purl.obolibrary.org/obo/GO_1901615 organic hydroxy compound metabolic process http://purl.obolibrary.org/obo/GO_0071704 organic substance metabolic process The chemical reactions and pathways involving organic hydroxy compound. http://purl.obolibrary.org/obo/GO_1901617 organic hydroxy compound biosynthetic process http://purl.obolibrary.org/obo/GO_1901615 organic hydroxy compound metabolic process The chemical reactions and pathways resulting in the formation of organic hydroxy compound. http://purl.obolibrary.org/obo/CHEBI_10545 electron http://purl.obolibrary.org/obo/CHEBI_36338 lepton Elementary particle not affected by the strong force having a spin 1/2, a negative elementary charge and a rest mass of 0.000548579903(13) u, or 0.51099906(15) MeV. http://purl.obolibrary.org/obo/CHEBI_36338 lepton http://purl.obolibrary.org/obo/CHEBI_36340 fermion Lepton is a fermion that does not experience the strong force (strong interaction). The term is derived from the Greek lambdaepsilonpitauomicronsigma (small, thin). http://purl.obolibrary.org/obo/CHEBI_77746 human metabolite http://purl.obolibrary.org/obo/CHEBI_75768 mammalian metabolite Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens). http://purl.obolibrary.org/obo/CHEBI_33672 heterobicyclic compound http://purl.obolibrary.org/obo/CHEBI_33636 bicyclic compound A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom. http://purl.obolibrary.org/obo/CHEBI_38323 cholinergic drug http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons. http://purl.obolibrary.org/obo/CHEBI_51151 dipolar compound http://purl.obolibrary.org/obo/CHEBI_72695 organic molecule An organic molecule that is electrically neutral carrying a positive and a negative charge in one of its major canonical descriptions. In most dipolar compounds the charges are delocalized; however the term is also applied to species where this is not the case. http://purl.obolibrary.org/obo/CHEBI_64047 food additive http://purl.obolibrary.org/obo/CHEBI_78295 food component Any substance which is added to food to preserve or enhance its flavour and/or appearance. http://purl.obolibrary.org/obo/CHEBI_36340 fermion http://purl.obolibrary.org/obo/CHEBI_36342 subatomic particle Particle of half-integer spin quantum number following Fermi-Dirac statistics. Fermions are named after Enrico Fermi. http://purl.obolibrary.org/obo/CHEBI_36343 composite particle http://purl.obolibrary.org/obo/CHEBI_36342 subatomic particle A subatomic particle known to have substructure (i.e. consisting of smaller particles). http://purl.obolibrary.org/obo/CHEBI_36344 hadron http://purl.obolibrary.org/obo/CHEBI_36343 composite particle Hadron is a subatomic particle which experiences the strong force. http://purl.obolibrary.org/obo/CHEBI_48540 beta-adrenergic drug http://purl.obolibrary.org/obo/CHEBI_37962 adrenergic agent Any of the drugs that act on beta-adrenergic receptors. http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role http://purl.obolibrary.org/obo/CHEBI_24432 biological role A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties. http://purl.obolibrary.org/obo/CHEBI_75787 prokaryotic metabolite http://purl.obolibrary.org/obo/CHEBI_25212 metabolite Any metabolite produced during a metabolic reaction in prokaryotes, the taxon that include members of domains such as the bacteria and archaea. http://purl.obolibrary.org/obo/CHEBI_76764 EC 3.5.* (hydrolases acting on non-peptide C-N bonds) inhibitor http://purl.obolibrary.org/obo/CHEBI_76759 EC 3.* (hydrolase) inhibitor Any hydrolase inhibitor that interferes with the action of a hydrolase acting on C-N bonds, other than peptide bonds (EC 3.5.*.*). http://purl.obolibrary.org/obo/CARO_0001010 organism http://purl.obolibrary.org/obo/BFO_0000040 material entity Material anatomical entity that is a member of an individual species or is a viral or viroid particle. http://purl.obolibrary.org/obo/CARO_0010004 cellular organism http://purl.obolibrary.org/obo/CARO_0000003 connected anatomical structure An individual member of a clade of cellular organisms. http://purl.obolibrary.org/obo/CHEBI_140601 fatty acid 4:0 http://purl.obolibrary.org/obo/CHEBI_26666 short-chain fatty acid Any saturated fatty acid containing 4 carbons. http://purl.obolibrary.org/obo/GO_0000035 acyl binding http://purl.obolibrary.org/obo/GO_0005488 binding Binding to an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid. http://purl.obolibrary.org/obo/GO_0001677 formation of translation initiation ternary complex http://purl.obolibrary.org/obo/GO_0022618 ribonucleoprotein complex assembly Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator). http://purl.obolibrary.org/obo/GO_0001692 histamine metabolic process http://purl.obolibrary.org/obo/GO_0097164 ammonium ion metabolic process The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. http://purl.obolibrary.org/obo/GO_0001694 histamine biosynthetic process http://purl.obolibrary.org/obo/GO_0042401 biogenic amine biosynthetic process The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. http://purl.obolibrary.org/obo/GO_0002054 nucleobase binding http://purl.obolibrary.org/obo/GO_1901363 heterocyclic compound binding Binding to a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases. http://purl.obolibrary.org/obo/GO_0003674 molecular_function http://purl.obolibrary.org/obo/BFO_0000015 process A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. http://purl.obolibrary.org/obo/GO_0003676 nucleic acid binding http://purl.obolibrary.org/obo/GO_1901363 heterocyclic compound binding Binding to a nucleic acid. http://purl.obolibrary.org/obo/GO_0003723 RNA binding http://purl.obolibrary.org/obo/GO_0003676 nucleic acid binding Binding to an RNA molecule or a portion thereof. http://purl.obolibrary.org/obo/GO_0003824 catalytic activity http://purl.obolibrary.org/obo/GO_0003674 molecular_function Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. http://purl.obolibrary.org/obo/GO_0005488 binding http://purl.obolibrary.org/obo/GO_0003674 molecular_function The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. http://purl.obolibrary.org/obo/GO_0005515 protein binding http://purl.obolibrary.org/obo/GO_0005488 binding Binding to a protein. http://purl.obolibrary.org/obo/GO_0005622 intracellular anatomical structure http://purl.obolibrary.org/obo/GO_0110165 cellular anatomical entity A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm. http://purl.obolibrary.org/obo/GO_0005634 nucleus http://purl.obolibrary.org/obo/GO_0043231 intracellular membrane-bounded organelle A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. http://purl.obolibrary.org/obo/GO_0005737 cytoplasm http://purl.obolibrary.org/obo/GO_0110165 cellular anatomical entity The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. http://purl.obolibrary.org/obo/GO_0005773 vacuole http://purl.obolibrary.org/obo/GO_0043231 intracellular membrane-bounded organelle A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol. http://purl.obolibrary.org/obo/GO_0005886 plasma membrane http://purl.obolibrary.org/obo/GO_0016020 membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. http://purl.obolibrary.org/obo/GO_0006412 translation http://purl.obolibrary.org/obo/GO_0043043 peptide biosynthetic process The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. http://purl.obolibrary.org/obo/GO_0006413 translational initiation http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. http://purl.obolibrary.org/obo/GO_0006414 translational elongation http://purl.obolibrary.org/obo/GO_0009059 macromolecule biosynthetic process The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. http://purl.obolibrary.org/obo/GO_0006415 translational termination http://purl.obolibrary.org/obo/GO_0032984 protein-containing complex disassembly The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). http://purl.obolibrary.org/obo/GO_0006520 amino acid metabolic process http://purl.obolibrary.org/obo/GO_1901564 organonitrogen compound metabolic process The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. http://purl.obolibrary.org/obo/GO_0006576 biogenic amine metabolic process http://purl.obolibrary.org/obo/GO_0009308 amine metabolic process The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. http://purl.obolibrary.org/obo/GO_0006631 fatty acid metabolic process http://purl.obolibrary.org/obo/GO_0044255 cellular lipid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. http://purl.obolibrary.org/obo/GO_0006633 fatty acid biosynthetic process http://purl.obolibrary.org/obo/GO_0072330 monocarboxylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. http://purl.obolibrary.org/obo/GO_0006997 nucleus organization http://purl.obolibrary.org/obo/GO_0006996 organelle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus. http://purl.obolibrary.org/obo/GO_0007009 plasma membrane organization http://purl.obolibrary.org/obo/GO_0061024 membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane. http://purl.obolibrary.org/obo/GO_0007033 vacuole organization http://purl.obolibrary.org/obo/GO_0006996 organelle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole. http://purl.obolibrary.org/obo/GO_0008047 enzyme activator activity http://purl.obolibrary.org/obo/GO_0140677 molecular function activator activity Binds to and increases the activity of an enzyme. http://purl.obolibrary.org/obo/GO_0008150 biological_process http://purl.obolibrary.org/obo/BFO_0000015 process A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. http://purl.obolibrary.org/obo/GO_0008289 lipid binding http://purl.obolibrary.org/obo/GO_0005488 binding Binding to a lipid. http://purl.obolibrary.org/obo/GO_0008652 amino acid biosynthetic process http://purl.obolibrary.org/obo/GO_1901566 organonitrogen compound biosynthetic process The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. http://purl.obolibrary.org/obo/GO_0009058 biosynthetic process http://purl.obolibrary.org/obo/GO_0008152 metabolic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. http://purl.obolibrary.org/obo/GO_0009059 macromolecule biosynthetic process http://purl.obolibrary.org/obo/GO_1901576 organic substance biosynthetic process The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. http://purl.obolibrary.org/obo/GO_0009064 glutamine family amino acid metabolic process http://purl.obolibrary.org/obo/GO_1901605 alpha-amino acid metabolic process The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline. http://purl.obolibrary.org/obo/GO_0009987 cellular process http://purl.obolibrary.org/obo/GO_0008150 biological_process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. http://purl.obolibrary.org/obo/GO_0010467 gene expression http://purl.obolibrary.org/obo/GO_0043170 macromolecule metabolic process The process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, translation and maturation for protein-coding genes. http://purl.obolibrary.org/obo/GO_0016070 RNA metabolic process http://purl.obolibrary.org/obo/GO_0090304 nucleic acid metabolic process The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. http://purl.obolibrary.org/obo/GO_0016301 kinase activity http://purl.obolibrary.org/obo/GO_0016772 transferase activity, transferring phosphorus-containing groups Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. http://purl.obolibrary.org/obo/GO_0016740 transferase activity http://purl.obolibrary.org/obo/GO_0003824 catalytic activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. http://purl.obolibrary.org/obo/GO_0018130 heterocycle biosynthetic process http://purl.obolibrary.org/obo/GO_0046483 heterocycle metabolic process The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). http://purl.obolibrary.org/obo/GO_0019438 aromatic compound biosynthetic process http://purl.obolibrary.org/obo/GO_0044249 cellular biosynthetic process The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring. http://purl.obolibrary.org/obo/GO_0022607 cellular component assembly http://purl.obolibrary.org/obo/GO_0016043 cellular component organization The aggregation, arrangement and bonding together of a cellular component. http://purl.obolibrary.org/obo/GO_0022618 ribonucleoprotein complex assembly http://purl.obolibrary.org/obo/GO_0071826 ribonucleoprotein complex subunit organization The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex. http://purl.obolibrary.org/obo/GO_0032774 RNA biosynthetic process http://purl.obolibrary.org/obo/GO_0034654 nucleobase-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication. http://purl.obolibrary.org/obo/GO_0032984 protein-containing complex disassembly http://purl.obolibrary.org/obo/GO_0043933 protein-containing complex organization The disaggregation of a protein-containing macromolecular complex into its constituent components. http://purl.obolibrary.org/obo/GO_0032988 ribonucleoprotein complex disassembly http://purl.obolibrary.org/obo/GO_0071826 ribonucleoprotein complex subunit organization The disaggregation of a protein-RNA complex into its constituent components. http://purl.obolibrary.org/obo/GO_0032991 protein-containing complex http://purl.obolibrary.org/obo/GO_0005575 cellular_component A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. http://purl.obolibrary.org/obo/GO_0033293 monocarboxylic acid binding http://purl.obolibrary.org/obo/GO_0031406 carboxylic acid binding Binding to a monocarboxylic acid, any organic acid containing one carboxyl (COOH) group or anion (COO-). http://purl.obolibrary.org/obo/GO_0036094 small molecule binding http://purl.obolibrary.org/obo/GO_0005488 binding Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule. http://purl.obolibrary.org/obo/GO_0042277 peptide binding http://purl.obolibrary.org/obo/GO_0033218 amide binding Binding to a peptide, an organic compound comprising two or more amino acids linked by peptide bonds. http://purl.obolibrary.org/obo/GO_0042401 biogenic amine biosynthetic process http://purl.obolibrary.org/obo/GO_0009309 amine biosynthetic process The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters. http://purl.obolibrary.org/obo/GO_0043043 peptide biosynthetic process http://purl.obolibrary.org/obo/GO_1901566 organonitrogen compound biosynthetic process The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide. http://purl.obolibrary.org/obo/GO_0043168 anion binding http://purl.obolibrary.org/obo/GO_0043167 ion binding Binding to an anion, a charged atom or group of atoms with a net negative charge. http://purl.obolibrary.org/obo/GO_0043178 alcohol binding http://purl.obolibrary.org/obo/GO_0036094 small molecule binding Binding to an alcohol, any of a class of alkyl compounds containing a hydroxyl group. http://purl.obolibrary.org/obo/GO_0043226 organelle http://purl.obolibrary.org/obo/GO_0110165 cellular anatomical entity Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane. http://purl.obolibrary.org/obo/GO_0043436 oxoacid metabolic process http://purl.obolibrary.org/obo/GO_0006082 organic acid metabolic process The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons). http://purl.obolibrary.org/obo/GO_0043603 amide metabolic process http://purl.obolibrary.org/obo/GO_0006807 nitrogen compound metabolic process The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells. http://purl.obolibrary.org/obo/GO_0043604 amide biosynthetic process http://purl.obolibrary.org/obo/GO_0044271 cellular nitrogen compound biosynthetic process The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. http://purl.obolibrary.org/obo/GO_0043933 protein-containing complex organization http://purl.obolibrary.org/obo/GO_0016043 cellular component organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex. http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process http://purl.obolibrary.org/obo/GO_0009987 cellular process The chemical reactions and pathways by which individual cells transform chemical substances. http://purl.obolibrary.org/obo/GO_0044271 cellular nitrogen compound biosynthetic process http://purl.obolibrary.org/obo/GO_0044249 cellular biosynthetic process The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds. http://purl.obolibrary.org/obo/GO_0044283 small molecule biosynthetic process http://purl.obolibrary.org/obo/GO_0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule. http://purl.obolibrary.org/obo/GO_0046165 alcohol biosynthetic process http://purl.obolibrary.org/obo/GO_0044283 small molecule biosynthetic process The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom. http://purl.obolibrary.org/obo/GO_0046219 indolalkylamine biosynthetic process http://purl.obolibrary.org/obo/GO_0042435 indole-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group. http://purl.obolibrary.org/obo/GO_0046394 carboxylic acid biosynthetic process http://purl.obolibrary.org/obo/GO_0016053 organic acid biosynthetic process The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups. http://purl.obolibrary.org/obo/GO_0046483 heterocycle metabolic process http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). http://purl.obolibrary.org/obo/GO_0052803 imidazole-containing compound metabolic process http://purl.obolibrary.org/obo/GO_1901564 organonitrogen compound metabolic process The chemical reactions and pathways involving imidazoles, five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton. http://purl.obolibrary.org/obo/GO_0061695 transferase complex, transferring phosphorus-containing groups http://purl.obolibrary.org/obo/GO_1990234 transferase complex A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). http://purl.obolibrary.org/obo/GO_0070925 organelle assembly http://purl.obolibrary.org/obo/GO_0022607 cellular component assembly The aggregation, arrangement and bonding together of a set of components to form an organelle. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. http://purl.obolibrary.org/obo/GO_0071709 membrane assembly http://purl.obolibrary.org/obo/GO_0022607 cellular component assembly The aggregation, arrangement and bonding together of a set of components to form a membrane. http://purl.obolibrary.org/obo/GO_0072330 monocarboxylic acid biosynthetic process http://purl.obolibrary.org/obo/GO_0046394 carboxylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of monocarboxylic acids, any organic acid containing one carboxyl (-COOH) group. http://purl.obolibrary.org/obo/GO_0097159 organic cyclic compound binding http://purl.obolibrary.org/obo/GO_0005488 binding Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure. http://purl.obolibrary.org/obo/GO_0097164 ammonium ion metabolic process http://purl.obolibrary.org/obo/GO_0006807 nitrogen compound metabolic process The chemical reactions and pathways involving the ammonium ion. http://purl.obolibrary.org/obo/GO_0098796 membrane protein complex http://purl.obolibrary.org/obo/GO_0032991 protein-containing complex Any protein complex that is part of a membrane. http://purl.obolibrary.org/obo/GO_0098797 plasma membrane protein complex http://purl.obolibrary.org/obo/GO_0098796 membrane protein complex Any protein complex that is part of the plasma membrane. http://purl.obolibrary.org/obo/GO_1901360 organic cyclic compound metabolic process http://purl.obolibrary.org/obo/GO_0071704 organic substance metabolic process The chemical reactions and pathways involving organic cyclic compound. http://purl.obolibrary.org/obo/GO_1901362 organic cyclic compound biosynthetic process http://purl.obolibrary.org/obo/GO_1901360 organic cyclic compound metabolic process The chemical reactions and pathways resulting in the formation of organic cyclic compound. http://purl.obolibrary.org/obo/GO_1901363 heterocyclic compound binding http://purl.obolibrary.org/obo/GO_0005488 binding Binding to heterocyclic compound. http://purl.obolibrary.org/obo/GO_1901564 organonitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_0071704 organic substance metabolic process The chemical reactions and pathways involving organonitrogen compound. http://purl.obolibrary.org/obo/GO_1901566 organonitrogen compound biosynthetic process http://purl.obolibrary.org/obo/GO_1901564 organonitrogen compound metabolic process The chemical reactions and pathways resulting in the formation of organonitrogen compound. http://purl.obolibrary.org/obo/GO_1901605 alpha-amino acid metabolic process http://purl.obolibrary.org/obo/GO_0006520 amino acid metabolic process The chemical reactions and pathways involving an alpha-amino acid. http://purl.obolibrary.org/obo/GO_1901607 alpha-amino acid biosynthetic process http://purl.obolibrary.org/obo/GO_1901605 alpha-amino acid metabolic process The chemical reactions and pathways resulting in the formation of an alpha-amino acid. http://purl.obolibrary.org/obo/GO_1902494 catalytic complex http://purl.obolibrary.org/obo/GO_0032991 protein-containing complex A protein complex which is capable of catalytic activity. http://purl.obolibrary.org/obo/GO_1990234 transferase complex http://purl.obolibrary.org/obo/GO_1902494 catalytic complex A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). http://purl.obolibrary.org/obo/GO_0019209 kinase activator activity http://purl.obolibrary.org/obo/GO_0019207 kinase regulator activity Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. http://purl.obolibrary.org/obo/GO_0019413 acetate biosynthetic process http://purl.obolibrary.org/obo/GO_0072330 monocarboxylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid. http://purl.obolibrary.org/obo/GO_0019695 choline metabolic process http://purl.obolibrary.org/obo/GO_0097164 ammonium ion metabolic process The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. http://purl.obolibrary.org/obo/GO_0022613 ribonucleoprotein complex biogenesis http://purl.obolibrary.org/obo/GO_0044085 cellular component biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex. http://purl.obolibrary.org/obo/GO_0031975 envelope http://purl.obolibrary.org/obo/GO_0110165 cellular anatomical entity A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers. http://purl.obolibrary.org/obo/GO_0033265 choline binding http://purl.obolibrary.org/obo/GO_0043169 cation binding Binding to choline, the amine 2-hydroxy-N,N,N-trimethylethanaminium. http://purl.obolibrary.org/obo/GO_0042165 neurotransmitter binding http://purl.obolibrary.org/obo/GO_0005488 binding Binding to a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell. http://purl.obolibrary.org/obo/GO_0042425 choline biosynthetic process http://purl.obolibrary.org/obo/GO_0019695 choline metabolic process The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine. http://purl.obolibrary.org/obo/GO_0043177 organic acid binding http://purl.obolibrary.org/obo/GO_0036094 small molecule binding Binding to an organic acid, any acidic compound containing carbon in covalent linkage. http://purl.obolibrary.org/obo/GO_0043227 membrane-bounded organelle http://purl.obolibrary.org/obo/GO_0043226 organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. http://purl.obolibrary.org/obo/GO_0044877 protein-containing complex binding http://purl.obolibrary.org/obo/GO_0005488 binding Binding to a macromolecular complex. http://purl.obolibrary.org/obo/GO_0046459 short-chain fatty acid metabolic process http://purl.obolibrary.org/obo/GO_0006631 fatty acid metabolic process The chemical reactions and pathways involving a fatty acid with an aliphatic tail of less than 6 carbons. http://purl.obolibrary.org/obo/GO_0050997 quaternary ammonium group binding http://purl.obolibrary.org/obo/GO_0005488 binding Binding to a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups. http://purl.obolibrary.org/obo/GO_0051790 short-chain fatty acid biosynthetic process http://purl.obolibrary.org/obo/GO_0046459 short-chain fatty acid metabolic process The chemical reactions and pathways resulting in the formation of a fatty acid with an aliphatic tail of less than 6 carbons. http://purl.obolibrary.org/obo/GO_0070405 ammonium ion binding http://purl.obolibrary.org/obo/GO_0043169 cation binding Binding to ammonium ions (NH4+). http://purl.obolibrary.org/obo/GO_0071763 nuclear membrane organization http://purl.obolibrary.org/obo/GO_0061024 membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear inner or outer membrane. http://purl.obolibrary.org/obo/GO_0071826 ribonucleoprotein complex subunit organization http://purl.obolibrary.org/obo/GO_0043933 protein-containing complex organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a ribonucleoprotein complex. http://purl.obolibrary.org/obo/GO_0099738 cell cortex region http://purl.obolibrary.org/obo/GO_0099568 cytoplasmic region The complete extent of cell cortex that underlies some some region of the plasma membrane. http://purl.obolibrary.org/obo/GO_1903008 organelle disassembly http://purl.obolibrary.org/obo/GO_0022411 cellular component disassembly The disaggregation of an organelle into its constituent components. http://purl.obolibrary.org/obo/GO_1990904 ribonucleoprotein complex http://purl.obolibrary.org/obo/GO_0032991 protein-containing complex A macromolecular complex that contains both RNA and protein molecules. http://purl.obolibrary.org/obo/GO_0034312 diol biosynthetic process http://purl.obolibrary.org/obo/GO_0046173 polyol biosynthetic process The chemical reactions and pathways resulting in the formation of a diol, any alcohol containing two hydroxyl groups attached to saturated carbon atoms. http://purl.obolibrary.org/obo/GO_0035834 indole alkaloid metabolic process http://purl.obolibrary.org/obo/GO_0009820 alkaloid metabolic process The chemical reactions and pathways involving an indole alkaloid, an alkaloid containing an indole skeleton. http://purl.obolibrary.org/obo/GO_0042417 dopamine metabolic process http://purl.obolibrary.org/obo/GO_0006807 nitrogen compound metabolic process The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline. http://purl.obolibrary.org/obo/GO_0042423 catecholamine biosynthetic process http://purl.obolibrary.org/obo/GO_0009713 catechol-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine. http://purl.obolibrary.org/obo/GO_0042428 serotonin metabolic process http://purl.obolibrary.org/obo/GO_0097164 ammonium ion metabolic process The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. http://purl.obolibrary.org/obo/GO_0043167 ion binding http://purl.obolibrary.org/obo/GO_0005488 binding Binding to an ion, a charged atoms or groups of atoms. http://purl.obolibrary.org/obo/GO_0043229 intracellular organelle http://purl.obolibrary.org/obo/GO_0043226 organelle Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. http://purl.obolibrary.org/obo/GO_0044207 translation initiation ternary complex http://purl.obolibrary.org/obo/GO_1990904 ribonucleoprotein complex A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator). http://purl.obolibrary.org/obo/GO_0046358 butyrate biosynthetic process http://purl.obolibrary.org/obo/GO_0019605 butyrate metabolic process The chemical reactions and pathways resulting in the formation of butyrate, the anion of butyric acid. http://purl.obolibrary.org/obo/GO_1901162 primary amino compound biosynthetic process http://purl.obolibrary.org/obo/GO_1901566 organonitrogen compound biosynthetic process The chemical reactions and pathways resulting in the formation of primary amino compound. http://purl.obolibrary.org/obo/GO_1901338 catecholamine binding http://purl.obolibrary.org/obo/GO_0097159 organic cyclic compound binding Binding to catecholamine. http://purl.obolibrary.org/obo/GO_1905690 nucleus disassembly http://purl.obolibrary.org/obo/GO_1903008 organelle disassembly The disaggregation of a nucleus into its constituent components. http://purl.obolibrary.org/obo/GO_0101025 nuclear membrane biogenesis http://purl.obolibrary.org/obo/GO_0044091 membrane biogenesis The process in which a nuclear membrane is synthesized, aggregates, and bonds together. http://purl.obolibrary.org/obo/PR_000018263 amino acid chain http://purl.obolibrary.org/obo/CHEBI_50047 organic amino compound An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds. http://purl.obolibrary.org/obo/PR_000036194 eukaryotic protein http://purl.obolibrary.org/obo/CHEBI_36080 protein A protein that is encoded in the genome of some Eukaryota. http://purl.obolibrary.org/obo/RO_0002577 system http://purl.obolibrary.org/obo/BFO_0000040 material entity A material entity consisting of multiple components that are causally integrated. http://purl.obolibrary.org/obo/CARO_0001008 gross anatomical part http://purl.obolibrary.org/obo/CARO_0000006 material anatomical entity Anatomical structure that is part of a multicellular organism and is at the gross anatomical level, e.g. above the level of a cell. Included are portions of organism substances such as blood, multi-cell-part structures such as axon tracts, acellular anatomical structures such as hair, and organism subdivisions such as head. Excluded is the whole organism and more granular parts of the organism, such as atoms, molecules, macromolecular complexes and cells. http://purl.obolibrary.org/obo/GO_0110165 cellular anatomical entity http://purl.obolibrary.org/obo/GO_0005575 cellular_component A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. http://purl.obolibrary.org/obo/GO_0140678 molecular function inhibitor activity http://purl.obolibrary.org/obo/GO_0098772 molecular function regulator activity A molecular function regulator that inhibits or decreases the activity of its target via non-covalent binding that does not result in covalent modification to the target. http://purl.obolibrary.org/obo/PATO_0070044 anatomical structure quality http://purl.obolibrary.org/obo/PATO_0001241 physical object quality A quality of continuant that exist at the anatomical level of organisation and anything under it. This includes, but is not limited to, cells , tissues, and components. http://purl.obolibrary.org/obo/GO_0008292 acetylcholine biosynthetic process http://purl.obolibrary.org/obo/GO_1900620 acetate ester biosynthetic process The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline. http://purl.obolibrary.org/obo/GO_0009308 amine metabolic process http://purl.obolibrary.org/obo/GO_1901564 organonitrogen compound metabolic process The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. http://purl.obolibrary.org/obo/GO_0009309 amine biosynthetic process http://purl.obolibrary.org/obo/GO_0009308 amine metabolic process The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom. http://purl.obolibrary.org/obo/GO_0009448 gamma-aminobutyric acid metabolic process http://purl.obolibrary.org/obo/GO_0006520 amino acid metabolic process The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. http://purl.obolibrary.org/obo/GO_0009449 gamma-aminobutyric acid biosynthetic process http://purl.obolibrary.org/obo/GO_0009448 gamma-aminobutyric acid metabolic process The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. http://purl.obolibrary.org/obo/GO_0009713 catechol-containing compound biosynthetic process http://purl.obolibrary.org/obo/GO_0046189 phenol-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent. http://purl.obolibrary.org/obo/GO_0009821 alkaloid biosynthetic process http://purl.obolibrary.org/obo/GO_1901566 organonitrogen compound biosynthetic process The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases). http://purl.obolibrary.org/obo/GO_0016053 organic acid biosynthetic process http://purl.obolibrary.org/obo/GO_0044283 small molecule biosynthetic process The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage. http://purl.obolibrary.org/obo/GO_0016597 amino acid binding http://purl.obolibrary.org/obo/GO_0043177 organic acid binding Binding to an amino acid, organic acids containing one or more amino substituents. http://purl.obolibrary.org/obo/GO_0016772 transferase activity, transferring phosphorus-containing groups http://purl.obolibrary.org/obo/GO_0016740 transferase activity Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). http://purl.obolibrary.org/obo/GO_0019207 kinase regulator activity http://purl.obolibrary.org/obo/GO_0030234 enzyme regulator activity Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule. http://purl.obolibrary.org/obo/GO_0019605 butyrate metabolic process http://purl.obolibrary.org/obo/GO_0046459 short-chain fatty acid metabolic process The chemical reactions and pathways involving any butyrate, the anions of butyric acid (butanoic acid), a saturated, unbranched aliphatic acid. http://purl.obolibrary.org/obo/GO_0030397 membrane disassembly http://purl.obolibrary.org/obo/GO_0061024 membrane organization The controlled breakdown of any cell membrane in the context of a normal process such as autophagy. http://purl.obolibrary.org/obo/GO_0031090 organelle membrane http://purl.obolibrary.org/obo/GO_0016020 membrane A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. http://purl.obolibrary.org/obo/GO_0034654 nucleobase-containing compound biosynthetic process http://purl.obolibrary.org/obo/GO_1901362 organic cyclic compound biosynthetic process The chemical reactions and pathways resulting in the formation of nucleobases, nucleosides, nucleotides and nucleic acids. http://purl.obolibrary.org/obo/GO_0035835 indole alkaloid biosynthetic process http://purl.obolibrary.org/obo/GO_0009821 alkaloid biosynthetic process The chemical reactions and pathways resulting in the formation of an indole alkaloid, an alkaloid containing an indole skeleton. http://purl.obolibrary.org/obo/GO_0042133 neurotransmitter metabolic process http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. http://purl.obolibrary.org/obo/GO_0042166 acetylcholine binding http://purl.obolibrary.org/obo/GO_0043169 cation binding Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions. http://purl.obolibrary.org/obo/GO_0042435 indole-containing compound biosynthetic process http://purl.obolibrary.org/obo/GO_1901566 organonitrogen compound biosynthetic process The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton. http://purl.obolibrary.org/obo/GO_0043169 cation binding http://purl.obolibrary.org/obo/GO_0043167 ion binding Binding to a cation, a charged atom or group of atoms with a net positive charge. http://purl.obolibrary.org/obo/GO_0044085 cellular component biogenesis http://purl.obolibrary.org/obo/GO_0071840 cellular component organization or biogenesis A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. http://purl.obolibrary.org/obo/GO_0044091 membrane biogenesis http://purl.obolibrary.org/obo/GO_0044085 cellular component biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane. http://purl.obolibrary.org/obo/GO_0046112 nucleobase biosynthetic process http://purl.obolibrary.org/obo/GO_1901566 organonitrogen compound biosynthetic process The chemical reactions and pathways resulting in the formation of a nucleobase, a nitrogenous base that is a constituent of a nucleic acid. http://purl.obolibrary.org/obo/GO_0071840 cellular component organization or biogenesis http://purl.obolibrary.org/obo/GO_0009987 cellular process A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component. http://purl.obolibrary.org/obo/GO_0098590 plasma membrane region http://purl.obolibrary.org/obo/GO_0016020 membrane A membrane that is a (regional) part of the plasma membrane. http://purl.obolibrary.org/obo/GO_1900619 acetate ester metabolic process http://purl.obolibrary.org/obo/GO_0071704 organic substance metabolic process The chemical reactions and pathways involving an acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid. http://purl.obolibrary.org/obo/GO_1900620 acetate ester biosynthetic process http://purl.obolibrary.org/obo/GO_1900619 acetate ester metabolic process The chemical reactions and pathways resulting in the formation of an acetate esteran acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid. http://purl.obolibrary.org/obo/GO_0140096 catalytic activity, acting on a protein http://purl.obolibrary.org/obo/GO_0003824 catalytic activity Catalytic activity that acts to modify a protein. http://purl.obolibrary.org/obo/GO_0140098 catalytic activity, acting on RNA http://purl.obolibrary.org/obo/GO_0140640 catalytic activity, acting on a nucleic acid Catalytic activity that acts to modify RNA, driven by ATP hydrolysis. http://purl.obolibrary.org/obo/CARO_0020003 cellular anatomical structure http://purl.obolibrary.org/obo/CARO_0000006 material anatomical entity An anatomical structure consisting of one or more cells. http://purl.obolibrary.org/obo/GO_0140640 catalytic activity, acting on a nucleic acid http://purl.obolibrary.org/obo/GO_0003824 catalytic activity Catalytic activity that acts to modify a nucleic acid. http://purl.obolibrary.org/obo/CARO_0000000 anatomical entity http://purl.obolibrary.org/obo/CARO_0030000 biological entity A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. http://purl.obolibrary.org/obo/CARO_0000003 connected anatomical structure http://purl.obolibrary.org/obo/CARO_0000006 material anatomical entity Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome. http://purl.obolibrary.org/obo/CARO_0000004 organism substance http://purl.obolibrary.org/obo/CARO_0001008 gross anatomical part Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body and that does not have inherent 3D shape generated by coordinated expression of the organism's own genome. http://purl.obolibrary.org/obo/CARO_0000005 anatomical space http://purl.obolibrary.org/obo/CARO_0000007 immaterial anatomical entity An Immaterial anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes and that is bounded by an anatomical surface. http://purl.obolibrary.org/obo/CARO_0000006 material anatomical entity http://purl.obolibrary.org/obo/CARO_0000000 anatomical entity An anatomical entity that has mass. http://purl.obolibrary.org/obo/CARO_0000007 immaterial anatomical entity http://purl.obolibrary.org/obo/CARO_0000000 anatomical entity Anatomical entity that has no mass. http://purl.obolibrary.org/obo/CARO_0000008 anatomical line http://purl.obolibrary.org/obo/CARO_0000007 immaterial anatomical entity A one dimensional, immaterial anatomical entity. http://purl.obolibrary.org/obo/CARO_0000009 anatomical point http://purl.obolibrary.org/obo/CARO_0000007 immaterial anatomical entity Non-material anatomical entity of zero dimension, which forms a boundary of an anatomical line or surface. http://purl.obolibrary.org/obo/CARO_0000010 anatomical boundary http://purl.obolibrary.org/obo/CARO_0000007 immaterial anatomical entity A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures. http://purl.obolibrary.org/obo/CARO_0000011 connected anatomical system http://purl.obolibrary.org/obo/CARO_0010000 multicellular anatomical structure Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function. http://purl.obolibrary.org/obo/CARO_0000012 multicellular organism http://purl.obolibrary.org/obo/CARO_0010004 cellular organism Anatomical structure that is an individual member of a clade and, at some point in its life-cycle, consists of more than one cell. http://purl.obolibrary.org/obo/CARO_0000013 cell http://purl.obolibrary.org/obo/CARO_0000003 connected anatomical structure An anatomical structure that has as its parts a maximally connected cell compartment surrounded by a plasma membrane. http://purl.obolibrary.org/obo/CARO_0000019 compound organ component http://purl.obolibrary.org/obo/CARO_0000055 multi-tissue structure Multi-tissue structure that is part of a compound organ. http://purl.obolibrary.org/obo/CARO_0000021 simple organ http://purl.obolibrary.org/obo/CARO_0020004 organ An organ that consists of a single multi-tissue structure. http://purl.obolibrary.org/obo/CARO_0000024 compound organ http://purl.obolibrary.org/obo/CARO_0020004 organ An organ consisting of multiple, distinct multi-tissue structures. http://purl.obolibrary.org/obo/CARO_0000027 male organism http://purl.obolibrary.org/obo/CARO_0000048 gonochoristic organism Gonochoristic organism that can produce male gametes. http://purl.obolibrary.org/obo/CARO_0000028 female organism http://purl.obolibrary.org/obo/CARO_0000048 gonochoristic organism Gonochoristic organism that can produce female gametes. http://purl.obolibrary.org/obo/CARO_0000032 organism subdivision http://purl.obolibrary.org/obo/CARO_0010000 multicellular anatomical structure Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument. http://purl.obolibrary.org/obo/CARO_0000040 acellular anatomical structure http://purl.obolibrary.org/obo/CARO_0000003 connected anatomical structure An anatomical structure that has no cells or cell parts as a part. http://purl.obolibrary.org/obo/CARO_0000042 extraembryonic structure http://purl.obolibrary.org/obo/CARO_0000003 connected anatomical structure A multicellular anatomical structure that is associated with an embryo and derived from the zygote from which it develops, but which does not contribute to the embryo proper or to structures that are part of the same organism after embryogenesis. http://purl.obolibrary.org/obo/CARO_0000049 protandrous hermaphroditic organism http://purl.obolibrary.org/obo/CARO_0000045 sequential hermaphroditic organism Sequential hermaphroditic organism that produces\ngametes first of the male sex, and then later of the\nfemale sex. http://purl.obolibrary.org/obo/CARO_0000050 protogynous hermaphroditic organism http://purl.obolibrary.org/obo/CARO_0000045 sequential hermaphroditic organism Sequential hermaphroditic organism that produces\ngametes first of the female sex, and then later of the\nmale sex. http://purl.obolibrary.org/obo/CARO_0000055 multi-tissue structure http://purl.obolibrary.org/obo/CARO_0010000 multicellular anatomical structure Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types. http://purl.obolibrary.org/obo/CARO_0000062 cell space http://purl.obolibrary.org/obo/CARO_0000005 anatomical space Anatomical space that is part of a cell. http://purl.obolibrary.org/obo/CARO_0000063 portion of cell substance http://purl.obolibrary.org/obo/CARO_0000004 organism substance Portion of organism substance located within a cell. http://purl.obolibrary.org/obo/CARO_0000066 epithelium http://purl.obolibrary.org/obo/CARO_0000043 tissue Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. http://purl.obolibrary.org/obo/CARO_0000067 simple cuboidal epithelium http://purl.obolibrary.org/obo/CARO_0000073 unilaminar epithelium Unilaminar epithelium that consists of a single layer of cuboidal cells. http://purl.obolibrary.org/obo/CARO_0000068 simple columnar epithlium http://purl.obolibrary.org/obo/CARO_0000073 unilaminar epithelium Unilaminar epithelium that consists of a single layer of columnar cells. http://purl.obolibrary.org/obo/CARO_0000069 multilaminar epithelium http://purl.obolibrary.org/obo/CARO_0000066 epithelium Epithelium that consists of more than one layer of epithelial cells. http://purl.obolibrary.org/obo/CARO_0000070 simple squamous epithelium http://purl.obolibrary.org/obo/CARO_0000073 unilaminar epithelium Unilaminar epithelium that consists of a single layer of squamous cells. http://purl.obolibrary.org/obo/CARO_0000071 atypical epithelium http://purl.obolibrary.org/obo/CARO_0000066 epithelium Epithelium that consists of epithelial cells not arranged in one ore more layers. http://purl.obolibrary.org/obo/CARO_0000072 cavitated compound organ http://purl.obolibrary.org/obo/CARO_0000024 compound organ Compound organ that contains one or more macroscopic anatomical spaces. http://purl.obolibrary.org/obo/CARO_0000073 unilaminar epithelium http://purl.obolibrary.org/obo/CARO_0000066 epithelium Epithelium that consists of a single layer of epithelial cells. http://purl.obolibrary.org/obo/CARO_0000074 solid compound organ http://purl.obolibrary.org/obo/CARO_0000024 compound organ Compound organ that does not contain macroscopic anatomical spaces. http://purl.obolibrary.org/obo/CARO_0000030 asexual multi-cellular organism http://purl.obolibrary.org/obo/CARO_0000012 multicellular organism Multi-cellular organism that does not produce gametes. http://purl.obolibrary.org/obo/CARO_0000081 circulating fluid http://purl.obolibrary.org/obo/CARO_0000004 organism substance A fluid that is circulated around a multicellular organism carrying nutrients and carrying away waste products. http://purl.obolibrary.org/obo/CARO_0000133 paired appendage http://purl.obolibrary.org/obo/CARO_0010003 appendage An appendage that is one of a bilateral pair. http://purl.obolibrary.org/obo/CARO_0001002 anatomical surface http://purl.obolibrary.org/obo/CARO_0001007 morphological boundary A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood. http://purl.obolibrary.org/obo/CARO_0001003 fiat anatomical boundary http://purl.obolibrary.org/obo/CARO_0000010 anatomical boundary A two dimensional anatomical entity that does not correspond to any physical discontinuity. http://purl.obolibrary.org/obo/CARO_0001004 bona-fide anatomical boundary http://purl.obolibrary.org/obo/CARO_0000010 anatomical boundary An anatomical boundary that corresponds to some physical discontinuity. http://purl.obolibrary.org/obo/CARO_0001005 gene expression boundary http://purl.obolibrary.org/obo/CARO_0001004 bona-fide anatomical boundary A two dimensional anatomical entity that is the boundary of a domain of expression of some gene. http://purl.obolibrary.org/obo/CARO_0001006 developmental compartment boundary http://purl.obolibrary.org/obo/CARO_0001004 bona-fide anatomical boundary A two dimensional anatomical entity that is not a morphological boundary and that cells do not cross during development. http://purl.obolibrary.org/obo/CARO_0001007 morphological boundary http://purl.obolibrary.org/obo/CARO_0001004 bona-fide anatomical boundary A two dimensional anatomical structure that corresponds to some structural discontinuity. http://purl.obolibrary.org/obo/CARO_0001500 neuron projection bundle segment http://purl.obolibrary.org/obo/CARO_0001000 multi-cell-part structure A fiber-shaped subdivision of a neuron projection along its long axis. http://purl.obolibrary.org/obo/CARO_0001501 neuron projection bundle subsegment http://purl.obolibrary.org/obo/CARO_0001000 multi-cell-part structure A subdivision of a neuron projection along its long axis that is as long as it is wide (and so does not qualify as fiber-shaped). http://purl.obolibrary.org/obo/CARO_0002000 epidermis http://purl.obolibrary.org/obo/CARO_0000066 epithelium Epithelium of the integumentary system. http://purl.obolibrary.org/obo/CARO_0002001 integumentary system http://purl.obolibrary.org/obo/CARO_0000011 connected anatomical system Connected anatomical system that forms a barrier between an animal and its environment - generally consisting of an epidermis, which may be covered by some acellular structure. http://purl.obolibrary.org/obo/CARO_0002002 aligned anatomical group http://purl.obolibrary.org/obo/CARO_0020000 disconnected anatomical group An anatomical group whose members are arranged in a line. http://purl.obolibrary.org/obo/CARO_0002003 clustered anatomical group http://purl.obolibrary.org/obo/CARO_0020000 disconnected anatomical group Anatomical group whose parts are close together, forming a cluster. http://purl.obolibrary.org/obo/CARO_0002004 segment body http://purl.obolibrary.org/obo/CARO_0000032 organism subdivision One of a set of semi-repetitive organism subdivisions serially arranged along the anterior-posterior axis of an organism and excluding appendages if present. http://purl.obolibrary.org/obo/CARO_0002005 appendage subdivision http://purl.obolibrary.org/obo/CARO_0000032 organism subdivision A subdivision of an appendage along its proximal-distal axis, consisting consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument. http://purl.obolibrary.org/obo/CARO_0002100 anatomical system http://purl.obolibrary.org/obo/CARO_0000000 anatomical entity An anatomical structure consisting of multiple cells, organs, tissues, distributed throught an organism, that act together to perform some physiological function. http://purl.obolibrary.org/obo/CARO_0002101 disconnected anatomical system http://purl.obolibrary.org/obo/CARO_0002100 anatomical system An anatomical system consisting of multiple disconnected parts. http://purl.obolibrary.org/obo/CARO_0010000 multicellular anatomical structure http://purl.obolibrary.org/obo/CARO_0000003 connected anatomical structure An anatomical structure that has more than one cell as a part. http://purl.obolibrary.org/obo/CARO_0010001 cell cluster organ http://purl.obolibrary.org/obo/CARO_0020004 organ A small cluster of cells of various types which form a discrete structure, largely delimited by a morphological boundary and whose components work together to make the whole structure capable of a specific function. http://purl.obolibrary.org/obo/CARO_0010002 compound cell cluster organ http://purl.obolibrary.org/obo/CARO_0020004 organ An anatomical structure consisting of multiple cell cluster organs, largely delimited by a morphological boundary and whose components work together to make the whole structure capable of a specific function. http://purl.obolibrary.org/obo/CARO_0010003 appendage http://purl.obolibrary.org/obo/CARO_0000032 organism subdivision An organism subdivision that protrudes from the body. http://purl.obolibrary.org/obo/CARO_0010005 segment http://purl.obolibrary.org/obo/CARO_0000032 organism subdivision One of a set of semi-repetitive organism subdivisions serially arranged along the anterior-posterior axis of an organism, including appendages if present. http://purl.obolibrary.org/obo/CARO_0010006 tagma http://purl.obolibrary.org/obo/CARO_0000032 organism subdivision A subdivision of the organism along the anterior-posterior axis that consists of multiple adjacent segments that are either fused, and/or share more structure with each other than with segments in adjacent tagmata. http://purl.obolibrary.org/obo/CARO_0010007 appendage segment http://purl.obolibrary.org/obo/CARO_0002005 appendage subdivision One of a set of semi-repetitive organism subdivisions serially arranged along the proximal-distal axis of an appendage http://purl.obolibrary.org/obo/CARO_0010009 epithelial tube http://purl.obolibrary.org/obo/CARO_0000066 epithelium An epithelium that is rolled into a tube. http://purl.obolibrary.org/obo/CARO_0020000 disconnected anatomical group http://purl.obolibrary.org/obo/CARO_0000006 material anatomical entity Material anatomical entity consisting of multiple anatomical structures that are not connected to each other. http://purl.obolibrary.org/obo/CARO_0020001 multi organ part structure http://purl.obolibrary.org/obo/CARO_0010000 multicellular anatomical structure A multicellular anatomical structure that has subparts of multiple organs as a part. http://purl.obolibrary.org/obo/CARO_0020002 cell cluster http://purl.obolibrary.org/obo/CARO_0010000 multicellular anatomical structure A cluster of cells, largely surrounded by a morphological boundary. http://purl.obolibrary.org/obo/CARO_0020004 organ http://purl.obolibrary.org/obo/CARO_0010000 multicellular anatomical structure A multicellular anatomical structure largely delimited by a morphological boundary whose components work together to make the whole structure capable of a specific function. http://purl.obolibrary.org/obo/CARO_0020005 single tissue organ http://purl.obolibrary.org/obo/CARO_0020004 organ An single tissue, largely surrounded by a morpholigical boundary, whose cells work together to make the whole structure capable of a specific function. http://purl.obolibrary.org/obo/CARO_0030000 biological entity http://purl.obolibrary.org/obo/BFO_0000004 independent continuant Entity that is, is part of, or derived from an organism, virus, or viroid or a collection of them. http://purl.obolibrary.org/obo/CARO_0030002 expression pattern http://purl.obolibrary.org/obo/CARO_0020003 cellular anatomical structure The mereological sum of all cells in a single organism in which expression of some specified gene occurs. http://purl.obolibrary.org/obo/GO_0140513 nuclear protein-containing complex http://purl.obolibrary.org/obo/GO_0032991 protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together in the nucleus. http://purl.obolibrary.org/obo/CHEBI_138675 gas molecular entity http://purl.obolibrary.org/obo/CHEBI_33579 main group molecular entity Any main group molecular entity that is gaseous at standard temperature and pressure (STP; 0degreeC and 100 kPa). http://purl.obolibrary.org/obo/GO_0150005 enzyme activator complex http://purl.obolibrary.org/obo/GO_0032991 protein-containing complex A protein complex capable of activating an enzyme. Activating subunits may dissociate from the catalytic unit before the enzyme is active. http://purl.obolibrary.org/obo/GO_0140677 molecular function activator activity http://purl.obolibrary.org/obo/GO_0098772 molecular function regulator activity A molecular function regulator that activates or increases the activity of its target via non-covalent binding that does not result in covalent modification to the target. http://purl.obolibrary.org/obo/CHEBI_22728 benzopyrrole http://purl.obolibrary.org/obo/CHEBI_38180 polycyclic heteroarene http://purl.obolibrary.org/obo/CHEBI_33670 heteromonocyclic compound http://purl.obolibrary.org/obo/CHEBI_33661 monocyclic compound http://purl.obolibrary.org/obo/CHEBI_35605 carbon oxoacid http://purl.obolibrary.org/obo/CHEBI_36963 organooxygen compound http://purl.obolibrary.org/obo/CHEBI_35693 dicarboxylic acid anion http://purl.obolibrary.org/obo/CHEBI_29067 carboxylic acid anion http://purl.obolibrary.org/obo/CHEBI_37022 amino-acid anion http://purl.obolibrary.org/obo/CHEBI_35352 organonitrogen compound http://purl.obolibrary.org/obo/CHEBI_50320 nucleoside residue http://purl.obolibrary.org/obo/CHEBI_33247 organic group http://purl.obolibrary.org/obo/CHEBI_50319 nucleotide residue http://purl.obolibrary.org/obo/CHEBI_33247 organic group http://purl.obolibrary.org/obo/CHEBI_51447 organic univalent group http://purl.obolibrary.org/obo/CHEBI_33247 organic group http://purl.obolibrary.org/obo/CHEBI_51446 organic divalent group http://purl.obolibrary.org/obo/CHEBI_33247 organic group http://purl.obolibrary.org/obo/CHEBI_33710 alpha-amino-acid residue http://purl.obolibrary.org/obo/CHEBI_33708 amino-acid residue http://purl.obolibrary.org/obo/CHEBI_27171 organic heterobicyclic compound http://purl.obolibrary.org/obo/CHEBI_33672 heterobicyclic compound http://purl.obolibrary.org/obo/CHEBI_24834 inorganic anion http://purl.obolibrary.org/obo/CHEBI_36914 inorganic ion http://purl.obolibrary.org/obo/CHEBI_33280 molecular messenger http://purl.obolibrary.org/obo/CHEBI_24432 biological role http://purl.obolibrary.org/obo/CHEBI_52211 physiological role http://purl.obolibrary.org/obo/CHEBI_24432 biological role http://purl.obolibrary.org/obo/CHEBI_38166 organic heteropolycyclic compound http://purl.obolibrary.org/obo/CHEBI_33671 heteropolycyclic compound http://purl.obolibrary.org/obo/CHEBI_25693 organic heteromonocyclic compound http://purl.obolibrary.org/obo/CHEBI_33670 heteromonocyclic compound http://purl.obolibrary.org/obo/CHEBI_36914 inorganic ion http://purl.obolibrary.org/obo/CHEBI_24870 ion http://purl.obolibrary.org/obo/CHEBI_49637 hydrogen atom http://purl.obolibrary.org/obo/CHEBI_33559 s-block element atom http://purl.obolibrary.org/obo/CHEBI_33242 inorganic hydride http://purl.obolibrary.org/obo/CHEBI_33692 hydrides http://purl.obolibrary.org/obo/CHEBI_25699 organic ion http://purl.obolibrary.org/obo/CHEBI_50860 organic molecular entity http://purl.obolibrary.org/obo/CHEBI_25555 nitrogen atom http://purl.obolibrary.org/obo/CHEBI_33300 pnictogen http://purl.obolibrary.org/obo/CHEBI_25805 oxygen atom http://purl.obolibrary.org/obo/CHEBI_33303 chalcogen http://purl.obolibrary.org/obo/CHEBI_27594 carbon atom http://purl.obolibrary.org/obo/CHEBI_33306 carbon group element atom http://purl.obolibrary.org/obo/CHEBI_25585 nonmetal atom http://purl.obolibrary.org/obo/CHEBI_33250 atom http://purl.obolibrary.org/obo/CHEBI_33559 s-block element atom http://purl.obolibrary.org/obo/CHEBI_33250 atom http://purl.obolibrary.org/obo/CHEBI_51143 nitrogen molecular entity http://purl.obolibrary.org/obo/CHEBI_33302 pnictogen molecular entity http://purl.obolibrary.org/obo/CHEBI_35881 pnictogen hydride http://purl.obolibrary.org/obo/CHEBI_33242 inorganic hydride http://purl.obolibrary.org/obo/CHEBI_25806 oxygen molecular entity http://purl.obolibrary.org/obo/CHEBI_33304 chalcogen molecular entity http://purl.obolibrary.org/obo/CHEBI_33306 carbon group element atom http://purl.obolibrary.org/obo/CHEBI_33560 p-block element atom http://purl.obolibrary.org/obo/CHEBI_33582 carbon group molecular entity http://purl.obolibrary.org/obo/CHEBI_33675 p-block molecular entity http://purl.obolibrary.org/obo/CHEBI_33659 organic aromatic compound http://purl.obolibrary.org/obo/CHEBI_33655 aromatic compound http://purl.obolibrary.org/obo/CHEBI_36915 inorganic cation http://purl.obolibrary.org/obo/CHEBI_36916 cation http://purl.obolibrary.org/obo/CHEBI_50312 onium compound http://purl.obolibrary.org/obo/CHEBI_37577 heteroatomic molecular entity http://purl.obolibrary.org/obo/CHEBI_50329 2-carboxyethyl group http://purl.obolibrary.org/obo/CHEBI_50325 proteinogenic amino-acid side-chain group http://purl.obolibrary.org/obo/CHEBI_35106 nitrogen hydride http://purl.obolibrary.org/obo/CHEBI_35881 pnictogen hydride http://purl.obolibrary.org/obo/CHEBI_23019 carbonyl group http://purl.obolibrary.org/obo/CHEBI_51422 organodiyl group http://purl.obolibrary.org/obo/BFO_0000141 immaterial entity http://purl.obolibrary.org/obo/BFO_0000004 independent continuant http://purl.obolibrary.org/obo/BFO_0000009 two-dimensional spatial region http://purl.obolibrary.org/obo/BFO_0000006 spatial region http://purl.obolibrary.org/obo/BFO_0000018 zero-dimensional spatial region http://purl.obolibrary.org/obo/BFO_0000006 spatial region http://purl.obolibrary.org/obo/BFO_0000026 one-dimensional spatial region http://purl.obolibrary.org/obo/BFO_0000006 spatial region http://purl.obolibrary.org/obo/BFO_0000034 function http://purl.obolibrary.org/obo/BFO_0000016 disposition http://purl.obolibrary.org/obo/BFO_0000016 disposition http://purl.obolibrary.org/obo/BFO_0000017 realizable entity http://purl.obolibrary.org/obo/BFO_0000019 quality http://purl.obolibrary.org/obo/BFO_0000020 specifically dependent continuant http://purl.obolibrary.org/obo/BFO_0000006 spatial region http://purl.obolibrary.org/obo/BFO_0000141 immaterial entity http://purl.obolibrary.org/obo/BFO_0000029 site http://purl.obolibrary.org/obo/BFO_0000141 immaterial entity http://purl.obolibrary.org/obo/CHEBI_23981 ethanolamines http://purl.obolibrary.org/obo/CHEBI_22478 amino alcohol http://purl.obolibrary.org/obo/CHEBI_46883 carboxy group http://purl.obolibrary.org/obo/CHEBI_33249 organyl group http://purl.obolibrary.org/obo/CHEBI_13941 carbamate http://purl.obolibrary.org/obo/CHEBI_37022 amino-acid anion http://purl.obolibrary.org/obo/CHEBI_43176 hydroxy group http://purl.obolibrary.org/obo/CHEBI_33246 inorganic group http://purl.obolibrary.org/obo/CHEBI_46629 oxo group http://purl.obolibrary.org/obo/CHEBI_33246 inorganic group http://purl.obolibrary.org/obo/CHEBI_29337 azanide http://purl.obolibrary.org/obo/CHEBI_79389 monovalent inorganic anion http://purl.obolibrary.org/obo/CHEBI_38631 aminoalkylindole http://purl.obolibrary.org/obo/CHEBI_24828 indoles http://purl.obolibrary.org/obo/CHEBI_38180 polycyclic heteroarene http://purl.obolibrary.org/obo/CHEBI_33833 heteroarene http://purl.obolibrary.org/obo/CHEBI_38179 monocyclic heteroarene http://purl.obolibrary.org/obo/CHEBI_33833 heteroarene http://purl.obolibrary.org/obo/CHEBI_33570 benzenediols http://purl.obolibrary.org/obo/CHEBI_33853 phenols http://purl.obolibrary.org/obo/CHEBI_33791 canonical nucleoside residue http://purl.obolibrary.org/obo/CHEBI_50320 nucleoside residue http://purl.obolibrary.org/obo/CHEBI_23213 choline ester http://purl.obolibrary.org/obo/CHEBI_35701 ester http://purl.obolibrary.org/obo/CHEBI_50297 canonical nucleotide residue http://purl.obolibrary.org/obo/CHEBI_50319 nucleotide residue http://purl.obolibrary.org/obo/CHEBI_33695 information biomacromolecule http://purl.obolibrary.org/obo/CHEBI_33694 biomacromolecule http://purl.obolibrary.org/obo/CHEBI_33635 polycyclic compound http://purl.obolibrary.org/obo/CHEBI_33595 cyclic compound http://purl.obolibrary.org/obo/CHEBI_33661 monocyclic compound http://purl.obolibrary.org/obo/CHEBI_33595 cyclic compound http://purl.obolibrary.org/obo/CHEBI_33608 hydrogen molecular entity http://purl.obolibrary.org/obo/CHEBI_33674 s-block molecular entity http://purl.obolibrary.org/obo/CHEBI_37176 mononuclear parent hydride http://purl.obolibrary.org/obo/CHEBI_33692 hydrides http://purl.obolibrary.org/obo/CHEBI_33700 proteinogenic amino-acid residue http://purl.obolibrary.org/obo/CHEBI_33710 alpha-amino-acid residue http://purl.obolibrary.org/obo/CHEBI_33792 canonical ribonucleoside residue http://purl.obolibrary.org/obo/CHEBI_33791 canonical nucleoside residue http://purl.obolibrary.org/obo/CHEBI_50299 canonical ribonucleotide residue http://purl.obolibrary.org/obo/CHEBI_50297 canonical nucleotide residue http://purl.obolibrary.org/obo/CARO_0010010 epithelial sac http://purl.obolibrary.org/obo/CARO_0000066 epithelium http://purl.obolibrary.org/obo/CARO_0001013 anatomical plane http://purl.obolibrary.org/obo/CARO_0001003 fiat anatomical boundary http://purl.obolibrary.org/obo/CARO_0000134 unpaired appendage http://purl.obolibrary.org/obo/CARO_0010003 appendage http://purl.obolibrary.org/obo/CHEBI_36342 subatomic particle A particle smaller than an atom. http://purl.obolibrary.org/obo/GO_0001505 regulation of neurotransmitter levels Any process that modulates levels of neurotransmitter. http://purl.obolibrary.org/obo/CARO_0000041 anatomical cluster Anatomical group that has its parts adjacent to one another. http://purl.obolibrary.org/obo/CARO_0000054 anatomical group Anatomical structure consisting of at least two non-overlapping organs, multi-tissue aggregates or portion of tissues or cells of different types that does not constitute an organism, organ, multi-tissue aggregate, or portion of tissue. http://purl.obolibrary.org/obo/CARO_0000065 basal lamina Acellular anatomical structure that consists of a thin sheet of fibrous proteins that underlie and support the cells of an epithelium. It separates the cells of an epithelium from any underlying tissue. http://purl.obolibrary.org/obo/CARO_0000077 epithelial cell Cell which has as its part a cytoskeleton that allows for tight cell to cell contact and which has apical-basal cell polarity. http://purl.obolibrary.org/obo/CARO_0001009 obsolete anatomical chamber Anatomical structure that surrounds an immaterial anatomical entity. http://purl.obolibrary.org/obo/CARO_0002006 obsolete body cavity A major anatomical space of an organism in which major organs are located. http://purl.obolibrary.org/obo/BFO_0000001 entity http://purl.obolibrary.org/obo/RO_0002234 has output http://purl.obolibrary.org/obo/RO_0000057 has participant produces p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p. http://purl.obolibrary.org/obo/RO_0000052 characteristic of http://purl.obolibrary.org/obo/RO_0002314 characteristic of part of inheres_in a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence. http://purl.obolibrary.org/obo/RO_0000079 function of http://purl.obolibrary.org/obo/RO_0000052 characteristic of is function of a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0000080 quality of http://purl.obolibrary.org/obo/RO_0000052 characteristic of quality_of a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0000085 has function http://purl.obolibrary.org/obo/RO_0000053 bearer of has_function a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0000086 has quality http://purl.obolibrary.org/obo/RO_0000053 bearer of has_quality a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0002000 boundary_of http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to surface of a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity http://purl.obolibrary.org/obo/RO_0002002 has 2D boundary http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to has_2D_boundary a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity http://purl.obolibrary.org/obo/BFO_0000051 has_part http://purl.obolibrary.org/obo/RO_0002131 overlaps has_part a core relation that holds between a whole and its part http://purl.obolibrary.org/obo/RO_0000087 has role http://purl.obolibrary.org/obo/RO_0000053 bearer of has_role a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0002327 enables http://purl.obolibrary.org/obo/RO_0002215 capable of is executing c enables p iff c is capable of p and c acts to execute p. http://purl.obolibrary.org/obo/RO_0002409 indirectly negatively regulates http://purl.obolibrary.org/obo/RO_0012012 indirectly regulates indirectly inhibits p indirectly negatively regulates q iff p is indirectly causally upstream of q and p negatively regulates q. http://purl.obolibrary.org/obo/RO_0002436 molecularly interacts with http://purl.obolibrary.org/obo/RO_0002434 interacts with molecularly binds with An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other. http://purl.obolibrary.org/obo/RO_0002449 directly negatively regulates activity of http://purl.obolibrary.org/obo/RO_0002448 directly regulates activity of directly inhibits The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B. http://purl.obolibrary.org/obo/BFO_0000062 preceded by http://purl.obolibrary.org/obo/RO_0002086 ends after preceded_by x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. http://purl.obolibrary.org/obo/RO_0000081 role of http://purl.obolibrary.org/obo/RO_0000052 characteristic of role_of a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/BFO_0000050 part_of http://purl.obolibrary.org/obo/RO_0002131 overlaps part_of a core relation that holds between a part and its whole http://purl.obolibrary.org/obo/RO_0002233 has input http://purl.obolibrary.org/obo/RO_0000057 has participant consumes p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p. http://purl.obolibrary.org/obo/RO_0002314 characteristic of part of http://purl.obolibrary.org/obo/RO_0002502 depends on inheres in part of q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w. http://purl.obolibrary.org/obo/RO_0002215 capable of http://purl.obolibrary.org/obo/RO_0002216 capable of part of has function realized in A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. http://purl.obolibrary.org/obo/RO_0002331 involved in http://purl.obolibrary.org/obo/RO_0002431 involved in or involved in regulation of enables part of c involved_in p if and only if c enables some process p', and p' is part of p http://purl.obolibrary.org/obo/RO_0002431 involved in or involved in regulation of http://purl.obolibrary.org/obo/RO_0002500 causal agent in process involved in or reguates c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p http://purl.obolibrary.org/obo/RO_0002101 fasciculates with http://purl.obolibrary.org/obo/RO_0002131 overlaps fasciculates with Relation between a neuron and the neuron projection bundle it fasciculates with. FOL: x fasciculates_with y iff: exists some 'neuron ; CL_0000540'(x), some 'neuron projection bundle ; CARO_0001001'(y), some 'neuron projection ; GO_0043005'(np), np part_of x AND np overlaps y AND np aligned_with y http://purl.obolibrary.org/obo/RO_0002110 has postsynaptic terminal in http://purl.obolibrary.org/obo/RO_0002130 has synaptic terminal in synapsed in Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. http://purl.obolibrary.org/obo/RO_0002113 has presynaptic terminal in http://purl.obolibrary.org/obo/RO_0002130 has synaptic terminal in synapses in Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. http://purl.obolibrary.org/obo/RO_0002130 has synaptic terminal in http://purl.obolibrary.org/obo/RO_0002131 overlaps has synapse in A relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input. http://purl.obolibrary.org/obo/RO_0002151 partially overlaps http://purl.obolibrary.org/obo/RO_0002131 overlaps proper overlaps x partially overlaps y iff there exists some z such that z is part of x and z is part of y, and it is also the case that neither x is part of y or y is part of x http://purl.obolibrary.org/obo/RO_0002216 capable of part of http://purl.obolibrary.org/obo/RO_0002500 causal agent in process has function in c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p. http://purl.obolibrary.org/obo/RO_0002329 part of structure that is capable of http://purl.obolibrary.org/obo/RO_0002328 functionally related to 0 this relation holds between c and p when c is part of some c', and c' is capable of p. http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within http://purl.obolibrary.org/obo/RO_0002501 causal relation between processes influences (processual) p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q. http://purl.obolibrary.org/obo/RO_0002132 has fasciculating neuron projection http://purl.obolibrary.org/obo/RO_0002131 overlaps has fasciculating component The relation between a neuron projection bundle and a neuron projection that is fasciculated with it. http://purl.obolibrary.org/obo/RO_0002224 starts with http://purl.obolibrary.org/obo/RO_0002222 temporally related to started by x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. http://purl.obolibrary.org/obo/RO_0002230 ends with http://purl.obolibrary.org/obo/RO_0002222 temporally related to finished by x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. http://purl.obolibrary.org/obo/RO_0002231 has start location http://purl.obolibrary.org/obo/RO_0002479 has part that occurs in starts with process that occurs in x 'has starts location' y if and only if there exists some process z such that x 'starts with' z and z 'occurs in' y http://purl.obolibrary.org/obo/RO_0002232 has end location http://purl.obolibrary.org/obo/RO_0002479 has part that occurs in ends with process that occurs in x 'has end location' y if and only if there exists some process z such that x 'ends with' z and z 'occurs in' y http://purl.obolibrary.org/obo/RO_0002407 indirectly positively regulates http://purl.obolibrary.org/obo/RO_0012012 indirectly regulates indirectly activates p indirectly positively regulates q iff p is indirectly causally upstream of q and p positively regulates q. http://purl.obolibrary.org/obo/RO_0002432 is active in http://purl.obolibrary.org/obo/RO_0002328 functionally related to executes activity in c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure. http://purl.obolibrary.org/obo/RO_0002450 directly positively regulates activity of http://purl.obolibrary.org/obo/RO_0002448 directly regulates activity of directly activates The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B. http://purl.obolibrary.org/obo/RO_0002025 has effector activity http://purl.obolibrary.org/obo/RO_0002017 has component activity A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity. http://purl.obolibrary.org/obo/RO_0040036 results in changes to anatomical or cellular structure http://purl.obolibrary.org/obo/RO_0000057 has participant p has anatomical participant c iff p has participant c, and c is an anatomical entity http://purl.obolibrary.org/obo/RO_0002100 has soma location http://purl.obolibrary.org/obo/RO_0002131 overlaps Relation between a neuron and an anatomical structure that its soma is part of. http://purl.obolibrary.org/obo/RO_0002160 only in taxon http://purl.obolibrary.org/obo/RO_0002162 in taxon x only in taxon y if and only if x is in taxon y, and there is no other organism z such that y!=z a and x is in taxon z. http://purl.obolibrary.org/obo/RO_0002162 in taxon http://purl.obolibrary.org/obo/RO_0002320 evolutionarily related to x is in taxon y if an only if y is an organism, and the relationship between x and y is one of: part of (reflexive), developmentally preceded by, derives from, secreted by, expressed. http://purl.obolibrary.org/obo/RO_0004007 has primary input or output http://purl.obolibrary.org/obo/RO_0000057 has participant p 'has primary input ot output' c iff either (a) p 'has primary input' c or (b) p 'has primary output' c. http://purl.obolibrary.org/obo/RO_0004008 has primary output http://purl.obolibrary.org/obo/RO_0004007 has primary input or output p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c. http://purl.obolibrary.org/obo/BFO_0000063 precedes http://purl.obolibrary.org/obo/RO_0002222 temporally related to x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. http://purl.obolibrary.org/obo/RO_0002223 starts http://purl.obolibrary.org/obo/BFO_0000050 part_of inverse of starts with http://purl.obolibrary.org/obo/RO_0002018 has component process http://purl.obolibrary.org/obo/RO_0002180 has component w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type. http://purl.obolibrary.org/obo/RO_0019000 regulates characteristic http://purl.obolibrary.org/obo/RO_0002410 causally related to A relationship that holds between a process and a characteristic in which process (P) regulates characteristic (C) iff: P results in the existence of C OR affects the intensity or magnitude of C. http://purl.obolibrary.org/obo/RO_0019001 positively regulates characteristic http://purl.obolibrary.org/obo/RO_0019000 regulates characteristic A relationship that holds between a process and a characteristic in which process (P) positively regulates characteristic (C) iff: P results in an increase in the intensity or magnitude of C. http://purl.obolibrary.org/obo/RO_0019002 negatively regulates characteristic http://purl.obolibrary.org/obo/RO_0019000 regulates characteristic A relationship that holds between a process and a characteristic in which process (P) negatively regulates characteristic (C) iff: P results in a decrease in the intensity or magnitude of C. http://purl.obolibrary.org/obo/RO_0002333 enabled by http://purl.obolibrary.org/obo/RO_0002328 functionally related to inverse of enables http://purl.obolibrary.org/obo/RO_0002404 causally downstream of http://purl.obolibrary.org/obo/RO_0002427 causally downstream of or within inverse of upstream of http://purl.obolibrary.org/obo/RO_0002412 immediately causally upstream of http://purl.obolibrary.org/obo/RO_0002411 causally upstream of p is immediately causally upstream of q iff p is causally upstream of q, and the end of p is coincident with the beginning of q. http://purl.obolibrary.org/obo/RO_0002448 directly regulates activity of http://purl.obolibrary.org/obo/RO_0011002 regulates activity of The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B. A and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B. http://purl.obolibrary.org/obo/RO_0002566 causally influences http://purl.obolibrary.org/obo/RO_0002506 causal relation between entities The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size). http://purl.obolibrary.org/obo/RO_0002263 acts upstream of http://purl.obolibrary.org/obo/RO_0002264 acts upstream of or within c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes. http://purl.obolibrary.org/obo/RO_0002304 causally upstream of, positive effect http://purl.obolibrary.org/obo/RO_0004047 causally upstream of or within, positive effect p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q. http://purl.obolibrary.org/obo/RO_0002305 causally upstream of, negative effect http://purl.obolibrary.org/obo/RO_0004046 causally upstream of or within, negative effect p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q. http://purl.obolibrary.org/obo/RO_0002131 overlaps http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to x overlaps y if and only if there exists some z such that x has part z and z part of y http://purl.obolibrary.org/obo/RO_0000091 has disposition http://purl.obolibrary.org/obo/RO_0000053 bearer of a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0000092 disposition of http://purl.obolibrary.org/obo/RO_0000052 characteristic of inverse of has disposition http://purl.obolibrary.org/obo/RO_0011002 regulates activity of http://purl.obolibrary.org/obo/RO_0002566 causally influences The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B. http://purl.obolibrary.org/obo/RO_0002411 causally upstream of http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q. http://purl.obolibrary.org/obo/RO_0002211 regulates http://purl.obolibrary.org/obo/RO_0002411 causally upstream of p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q. http://purl.obolibrary.org/obo/RO_0002212 negatively regulates http://purl.obolibrary.org/obo/RO_0002211 regulates p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q. http://purl.obolibrary.org/obo/RO_0002213 positively regulates http://purl.obolibrary.org/obo/RO_0002211 regulates p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q. http://purl.obolibrary.org/obo/RO_0002180 has component http://purl.obolibrary.org/obo/BFO_0000051 has_part w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type. http://purl.obolibrary.org/obo/RO_0002352 input of http://purl.obolibrary.org/obo/RO_0002328 functionally related to inverse of has input http://purl.obolibrary.org/obo/RO_0002353 output of http://purl.obolibrary.org/obo/RO_0002328 functionally related to inverse of has output http://purl.obolibrary.org/obo/RO_0002023 directly negatively regulated by http://purl.obolibrary.org/obo/RO_0002022 directly regulated by Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1. http://purl.obolibrary.org/obo/RO_0002024 directly positively regulated by http://purl.obolibrary.org/obo/RO_0002022 directly regulated by Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1. http://purl.obolibrary.org/obo/RO_0012011 indirectly causally upstream of http://purl.obolibrary.org/obo/RO_0002411 causally upstream of p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q. http://purl.obolibrary.org/obo/RO_0012012 indirectly regulates http://purl.obolibrary.org/obo/RO_0012011 indirectly causally upstream of p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q. http://purl.obolibrary.org/obo/RO_0002170 connected to http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to a is connected to b if and only if a and b are discrete structure, and there exists some connecting structure c, such that c connects a and b http://purl.obolibrary.org/obo/RO_0002264 acts upstream of or within http://purl.obolibrary.org/obo/RO_0002500 causal agent in process c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process. http://purl.obolibrary.org/obo/RO_0004031 enables subfunction http://purl.obolibrary.org/obo/RO_0002328 functionally related to Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P. http://purl.obolibrary.org/obo/RO_0004034 acts upstream of, positive effect http://purl.obolibrary.org/obo/RO_0004032 acts upstream of or within, positive effect c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive http://purl.obolibrary.org/obo/RO_0004035 acts upstream of, negative effect http://purl.obolibrary.org/obo/RO_0004033 acts upstream of or within, negative effect c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative http://purl.obolibrary.org/obo/RO_0002103 synapsed by http://purl.obolibrary.org/obo/RO_0002485 receives input from Relation between an anatomical structure and a neuron that chemically synapses to it. http://purl.obolibrary.org/obo/RO_0002120 synapsed to http://purl.obolibrary.org/obo/RO_0002486 sends output to Relation between a neuron and an anatomical structure that it chemically synapses to. http://purl.obolibrary.org/obo/RO_0002334 regulated by http://purl.obolibrary.org/obo/RO_0002427 causally downstream of or within inverse of regulates http://purl.obolibrary.org/obo/RO_0002335 negatively regulated by http://purl.obolibrary.org/obo/RO_0002334 regulated by inverse of negatively regulates http://purl.obolibrary.org/obo/RO_0002336 positively regulated by http://purl.obolibrary.org/obo/RO_0002334 regulated by inverse of positively regulates http://purl.obolibrary.org/obo/RO_0002427 causally downstream of or within http://purl.obolibrary.org/obo/RO_0002501 causal relation between processes inverse of causally upstream of or within http://purl.obolibrary.org/obo/RO_0002500 causal agent in process http://purl.obolibrary.org/obo/RO_0002595 causal relation between material entity and a process A relationship between a material entity and a process where the material entity has some causal role that influences the process http://purl.obolibrary.org/obo/RO_0002501 causal relation between processes http://purl.obolibrary.org/obo/RO_0002410 causally related to p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q. http://purl.obolibrary.org/obo/RO_0002584 has part structure that is capable of http://purl.obolibrary.org/obo/RO_0002595 causal relation between material entity and a process s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p http://purl.obolibrary.org/obo/RO_0002595 causal relation between material entity and a process http://purl.obolibrary.org/obo/RO_0002410 causally related to A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity. http://purl.obolibrary.org/obo/RO_0002596 capable of regulating http://purl.obolibrary.org/obo/RO_0002500 causal agent in process Holds between c and p if and only if c is capable of some activity a, and a regulates p. http://purl.obolibrary.org/obo/RO_0002597 capable of negatively regulating http://purl.obolibrary.org/obo/RO_0002596 capable of regulating Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p. http://purl.obolibrary.org/obo/RO_0002598 capable of positively regulating http://purl.obolibrary.org/obo/RO_0002596 capable of regulating Holds between c and p if and only if c is capable of some activity a, and a positively regulates p. http://purl.obolibrary.org/obo/RO_0002608 process has causal agent http://purl.obolibrary.org/obo/RO_0002410 causally related to Inverse of 'causal agent in process' http://purl.obolibrary.org/obo/RO_0002015 has positive regulatory component activity http://purl.obolibrary.org/obo/RO_0002013 has regulatory component activity A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B. http://purl.obolibrary.org/obo/RO_0002013 has regulatory component activity http://purl.obolibrary.org/obo/RO_0002017 has component activity A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B. http://purl.obolibrary.org/obo/RO_0002014 has negative regulatory component activity http://purl.obolibrary.org/obo/RO_0002013 has regulatory component activity A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B. http://purl.obolibrary.org/obo/RO_0002229 ends http://purl.obolibrary.org/obo/BFO_0000050 part_of inverse of ends with http://purl.obolibrary.org/obo/RO_0002295 results in developmental progression of http://purl.obolibrary.org/obo/RO_0002324 developmentally related to p results in the developmental progression of s iff p is a developmental process and s is an anatomical entity and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss). http://purl.obolibrary.org/obo/RO_0002428 involved in regulation of http://purl.obolibrary.org/obo/RO_0002431 involved in or involved in regulation of c involved in regulation of p if c is involved in some p' and p' regulates some p http://purl.obolibrary.org/obo/RO_0002429 involved in positive regulation of http://purl.obolibrary.org/obo/RO_0002428 involved in regulation of c involved in regulation of p if c is involved in some p' and p' positively regulates some p http://purl.obolibrary.org/obo/RO_0002430 involved in negative regulation of http://purl.obolibrary.org/obo/RO_0002428 involved in regulation of c involved in regulation of p if c is involved in some p' and p' negatively regulates some p http://purl.obolibrary.org/obo/RO_0002578 directly regulates http://purl.obolibrary.org/obo/RO_0002211 regulates p directly regulates q iff p is immediately causally upstream of q and p regulates q. http://purl.obolibrary.org/obo/RO_0002586 results in breakdown of http://purl.obolibrary.org/obo/RO_0002233 has input p results in breakdown of c if and only if the execution of p leads to c no longer being present at the end of p http://purl.obolibrary.org/obo/RO_0002592 results in organization of http://purl.obolibrary.org/obo/RO_0000057 has participant p results in organization of c iff p results in the assembly, arrangement of constituent parts, or disassembly of c http://purl.obolibrary.org/obo/RO_0002629 directly positively regulates http://purl.obolibrary.org/obo/RO_0002578 directly regulates p directly positively regulates q iff p is immediately causally upstream of q, and p positively regulates q. http://purl.obolibrary.org/obo/RO_0002630 directly negatively regulates http://purl.obolibrary.org/obo/RO_0002578 directly regulates p directly negatively regulates q iff p is immediately causally upstream of q, and p negatively regulates q. http://purl.obolibrary.org/obo/RO_0002087 immediately preceded by http://purl.obolibrary.org/obo/BFO_0000062 preceded by starts_at_end_of http://purl.obolibrary.org/obo/RO_0002090 immediately precedes http://purl.obolibrary.org/obo/BFO_0000063 precedes meets http://purl.obolibrary.org/obo/RO_0002447 phosphorylates http://purl.obolibrary.org/obo/RO_0002436 molecularly interacts with An interaction relation between x and y in which x catalyzes a reaction in which a phosphate group is added to y. http://purl.obolibrary.org/obo/RO_0002297 results in formation of http://purl.obolibrary.org/obo/RO_0002295 results in developmental progression of http://purl.obolibrary.org/obo/RO_0002405 immediately causally downstream of http://purl.obolibrary.org/obo/RO_0002404 causally downstream of http://purl.obolibrary.org/obo/RO_0002017 has component activity http://purl.obolibrary.org/obo/RO_0002018 has component process http://purl.obolibrary.org/obo/RO_0002559 causally influenced by http://purl.obolibrary.org/obo/RO_0002506 causal relation between entities http://purl.obolibrary.org/obo/RO_0002563 interaction relation helper property http://purl.obolibrary.org/obo/RO_0002464 helper property (not for use in curation) http://purl.obolibrary.org/obo/RO_0002564 molecular interaction relation helper property http://purl.obolibrary.org/obo/RO_0002563 interaction relation helper property http://purl.obolibrary.org/obo/RO_0002481 is kinase activity http://purl.obolibrary.org/obo/RO_0002564 molecular interaction relation helper property http://purl.obolibrary.org/obo/RO_0002006 has synaptic terminal of http://purl.obolibrary.org/obo/RO_0002131 overlaps http://purl.obolibrary.org/obo/RO_0002086 ends after http://purl.obolibrary.org/obo/RO_0002222 temporally related to http://purl.obolibrary.org/obo/RO_0002354 formed as result of http://purl.obolibrary.org/obo/RO_0002353 output of http://purl.obolibrary.org/obo/RO_0002485 receives input from http://purl.obolibrary.org/obo/RO_0002170 connected to http://purl.obolibrary.org/obo/RO_0002486 sends output to http://purl.obolibrary.org/obo/RO_0002170 connected to http://purl.obolibrary.org/obo/RO_0004033 acts upstream of or within, negative effect http://purl.obolibrary.org/obo/RO_0002264 acts upstream of or within http://purl.obolibrary.org/obo/RO_0004032 acts upstream of or within, positive effect http://purl.obolibrary.org/obo/RO_0002264 acts upstream of or within http://purl.obolibrary.org/obo/RO_0002022 directly regulated by http://purl.obolibrary.org/obo/RO_0002334 regulated by http://purl.obolibrary.org/obo/RO_0002506 causal relation between entities http://purl.obolibrary.org/obo/RO_0002410 causally related to http://purl.obolibrary.org/obo/RO_0004046 causally upstream of or within, negative effect http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within http://purl.obolibrary.org/obo/RO_0004047 causally upstream of or within, positive effect http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within http://purl.obolibrary.org/obo/RO_0002588 results in assembly of http://purl.obolibrary.org/obo/RO_0002592 results in organization of http://purl.obolibrary.org/obo/RO_0002590 results in disassembly of http://purl.obolibrary.org/obo/RO_0002592 results in organization of http://purl.obolibrary.org/obo/RO_0000053 has characteristic is bearer of Inverse of characteristic_of http://purl.obolibrary.org/obo/RO_0000056 participates in participates_in a relation between a continuant and a process, in which the continuant is somehow involved in the process http://purl.obolibrary.org/obo/RO_0000057 has participant has_participant a relation between a process and a continuant, in which the continuant is somehow involved in the process http://purl.obolibrary.org/obo/BFO_0000066 occurs in unfolds_in b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t http://purl.obolibrary.org/obo/RO_0002320 evolutionarily related to A relationship that holds via some environmental process http://purl.obolibrary.org/obo/RO_0002324 developmentally related to A relationship that holds between entities participating in some developmental process (GO:0032502) http://purl.obolibrary.org/obo/BFO_0000067 contains process [copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t http://purl.obolibrary.org/obo/RO_0017001 device utilizes material X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y. http://purl.obolibrary.org/obo/RO_0003000 produces a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix. http://purl.obolibrary.org/obo/RO_0003001 produced by a produced_by b iff some process that occurs_in b has_output a. http://purl.obolibrary.org/obo/RO_0002434 interacts with A relationship that holds between two entities in which the processes executed by the two entities are causally connected. http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to A mereological relationship or a topological relationship http://purl.obolibrary.org/obo/RO_0002328 functionally related to A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities. http://purl.obolibrary.org/obo/RO_0015011 has cross section s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2. http://purl.obolibrary.org/obo/RO_0002134 innervates Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. http://purl.obolibrary.org/obo/RO_0002410 causally related to relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause. http://purl.obolibrary.org/obo/RO_0002479 has part that occurs in p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c. http://purl.obolibrary.org/obo/RO_0002464 helper property (not for use in curation) http://purl.obolibrary.org/obo/RO_0002222 temporally related to http://purl.obolibrary.org/obo/RO_0002502 depends on http://purl.obolibrary.org/obo/RO_0002005 innervated_by