Term IRI Term label Parent term IRI Parent term label Alternative term Definition http://purl.obolibrary.org/obo/CHEBI_25512 neurotransmitter http://purl.obolibrary.org/obo/CHEBI_33280 molecular messenger An endogenous compound that is used to transmit information across the synapse between a neuron and another cell. http://purl.obolibrary.org/obo/CHEBI_27311 volatile oil component http://purl.obolibrary.org/obo/CHEBI_26619 secondary metabolite Any secondary metabolite that is found naturally as a component of a volatile oil. http://purl.obolibrary.org/obo/CHEBI_35444 antinematodal drug http://purl.obolibrary.org/obo/CHEBI_35443 anthelminthic drug A substance used in the treatment or control of nematode infestations. http://purl.obolibrary.org/obo/CHEBI_35469 antidepressant http://purl.obolibrary.org/obo/CHEBI_35471 psychotropic drug Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. http://purl.obolibrary.org/obo/CHEBI_48318 fragrance http://purl.obolibrary.org/obo/CHEBI_33232 application A substance, extract, or preparation for diffusing or imparting an agreeable or attractive smell. http://purl.obolibrary.org/obo/CHEBI_49201 anti-ulcer drug http://purl.obolibrary.org/obo/CHEBI_23888 drug One of various classes of drugs with different action mechanisms used to treat or ameliorate peptic ulcer or irritation of the gastrointestinal tract. http://purl.obolibrary.org/obo/CHEBI_50218 phosphodiesterase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Compound which inhibits or antagonizes the biosynthesis or actions of phosphodiesterases. http://purl.obolibrary.org/obo/CHEBI_50268 GABA modulator http://purl.obolibrary.org/obo/CHEBI_51374 GABA agent A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. http://purl.obolibrary.org/obo/CHEBI_50902 genotoxin http://purl.obolibrary.org/obo/CHEBI_52209 aetiopathogenetic role A role played by a chemical compound to induce direct or indirect DNA damage. Such damage can potentially lead to the formation of a malignant tumour, but DNA damage does not lead inevitably to the creation of cancerous cells. http://purl.obolibrary.org/obo/CHEBI_50904 allergenic agent http://purl.obolibrary.org/obo/CHEBI_52209 aetiopathogenetic role A role played by a chemical compound in the onset of allergic reaction and interacting with molecular pathways involved in allergy. http://purl.obolibrary.org/obo/CHEBI_55324 gastrointestinal drug http://purl.obolibrary.org/obo/CHEBI_23888 drug A drug used for its effects on the gastrointestinal system, e.g. controlling gastric acidity, regulating gastrointestinal motility and water flow, and improving digestion. http://purl.obolibrary.org/obo/CHEBI_59163 biomarker http://purl.obolibrary.org/obo/CHEBI_47867 indicator A substance used as an indicator of a biological state. http://purl.obolibrary.org/obo/CHEBI_64915 antiplasmodial drug http://purl.obolibrary.org/obo/CHEBI_35820 antiprotozoal drug An antiparasitic drug which is effective against Apicomplexan parasites in the genus Plasmodium. The genus contains over 200 species and includes those responsible for malaria. http://purl.obolibrary.org/obo/CHEBI_67079 anti-inflammatory agent http://purl.obolibrary.org/obo/CHEBI_33232 application Any compound that has anti-inflammatory effects. http://purl.obolibrary.org/obo/CHEBI_67200 provitamin A http://purl.obolibrary.org/obo/CHEBI_50188 provitamin A provitamin that can be converted into vitamin A by enzymes from animal tissues. http://purl.obolibrary.org/obo/CHEBI_72575 alarm pheromone http://purl.obolibrary.org/obo/CHEBI_26013 pheromone A pheromone which is released by an organism when damaged by a predator which warns other individuals that there is a danger. http://purl.obolibrary.org/obo/CHEBI_24527 herbicide http://purl.obolibrary.org/obo/CHEBI_25944 pesticide A substance used to destroy plant pests. http://purl.obolibrary.org/obo/CHEBI_33231 antitubercular agent http://purl.obolibrary.org/obo/CHEBI_64912 antimycobacterial drug A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis. http://purl.obolibrary.org/obo/CHEBI_37699 protein kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An agent that inhibits protein kinases. http://purl.obolibrary.org/obo/CHEBI_47868 photosensitizing agent http://purl.obolibrary.org/obo/CHEBI_23888 drug A chemical compound that can be excited by light of a specific wavelength and subsequently transfer energy to a chosen reactant. This is commonly molecular oxygen within a cancer tissue, which is converted to (highly rective) singlet state oxygen. This rapidly reacts with any nearby biomolecules, ultimately killing the cancer cells. http://purl.obolibrary.org/obo/CHEBI_51039 dopamine uptake inhibitor http://purl.obolibrary.org/obo/CHEBI_50184 ion transport inhibitor A dopaminergic agent that blocks the transport of dopamine into axon terminals or into storage vesicles within terminals. Most of the adrenergic uptake inhibitors also inhibit dopamine uptake. http://purl.obolibrary.org/obo/CHEBI_64049 acidity regulator http://purl.obolibrary.org/obo/CHEBI_64047 food additive A food additive that is used to change or otherwise control the acidity and alkalinity of foods. They may be acids, bases, neutralising agents or bufffering agents. http://purl.obolibrary.org/obo/CHEBI_64345 MALDI matrix material http://purl.obolibrary.org/obo/CHEBI_33232 application A compound used to form the matrix for MALDI (matrix-assisted laser desorption/ionization) mass spectrometry. MALDI matrix materials are crystalline compounds with a fairly low molecular weight, so as to allow facile vaporization, have strong absorption at UV or IR wavelengths (to rapidly and efficiently absorb laser irradiation), generally contain polar groups (enabling them to be used in aqueous solutions) and are frequently acidic (so assisting ionisation of the compound being studied, which is contained within the matrix material). http://purl.obolibrary.org/obo/CHEBI_68494 apoptosis inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role Any substance that inhibits the process of apoptosis (programmed cell death) in multi-celled organisms. http://purl.obolibrary.org/obo/CHEBI_74783 astringent http://purl.obolibrary.org/obo/CHEBI_23888 drug A compound that causes the contraction of body tissues, typically used to reduce bleeding from minor abrasions. http://purl.obolibrary.org/obo/CHEBI_13193 hydrogen acceptor http://purl.obolibrary.org/obo/CHEBI_17654 electron acceptor A molecular entity that can undergo reduction by the gain of hydrogen atom(s). http://purl.obolibrary.org/obo/CHEBI_17499 hydrogen donor http://purl.obolibrary.org/obo/CHEBI_15022 electron donor A molecular entity that can undergo oxidation by the loss of hydrogen atom(s). http://purl.obolibrary.org/obo/CHEBI_17654 electron acceptor http://purl.obolibrary.org/obo/CHEBI_15339 acceptor A substance to which an electron may be transferred. http://purl.obolibrary.org/obo/CHEBI_22333 alkylating agent http://purl.obolibrary.org/obo/CHEBI_25435 mutagen Highly reactive chemical that introduces alkyl radicals into biologically active molecules and thereby prevents their proper functioning. It could be used as an antineoplastic agent, but it might be very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. It could also be used as a component of poison gases. http://purl.obolibrary.org/obo/CHEBI_22583 antifeedant http://purl.obolibrary.org/obo/CHEBI_25944 pesticide A substance that prevents pests from feeding. http://purl.obolibrary.org/obo/CHEBI_22917 phytogenic insecticide http://purl.obolibrary.org/obo/CHEBI_24852 insecticide An insecticide compound naturally occurring in plants. http://purl.obolibrary.org/obo/CHEBI_23357 cofactor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role An organic molecule or ion (usually a metal ion) that is required by an enzyme for its activity. It may be attached either loosely (coenzyme) or tightly (prosthetic group). http://purl.obolibrary.org/obo/CHEBI_24852 insecticide http://purl.obolibrary.org/obo/CHEBI_25944 pesticide Strictly, a substance intended to kill members of the class Insecta. In common usage, any substance used for preventing, destroying, repelling or controlling insects. http://purl.obolibrary.org/obo/CHEBI_25491 nematicide http://purl.obolibrary.org/obo/CHEBI_25944 pesticide A substance used to destroy pests of the phylum Nematoda (roundworms). http://purl.obolibrary.org/obo/CHEBI_26013 pheromone http://purl.obolibrary.org/obo/CHEBI_26645 semiochemical Substance used in olfactory communication between organisms of the same species eliciting a change in sexual or social behaviour. http://purl.obolibrary.org/obo/CHEBI_26155 plant growth regulator http://purl.obolibrary.org/obo/CHEBI_39317 growth regulator A chemical, natural or artificial, that can affect the rate of growth of a plant. http://purl.obolibrary.org/obo/CHEBI_26645 semiochemical http://purl.obolibrary.org/obo/CHEBI_33280 molecular messenger A molecular messenger released by an organism that affects the behaviour within or between species. http://purl.obolibrary.org/obo/CHEBI_26841 synthetic auxin http://purl.obolibrary.org/obo/CHEBI_22676 auxin A synthetic compound exhibiting auxin activity. http://purl.obolibrary.org/obo/CHEBI_27026 toxin http://purl.obolibrary.org/obo/CHEBI_26619 secondary metabolite Poisonous substance produced by a biological organism such as a microbe, animal or plant. http://purl.obolibrary.org/obo/CHEBI_27780 detergent http://purl.obolibrary.org/obo/CHEBI_33232 application A surfactant (or a mixture containing one or more surfactants) having cleaning properties in dilute solutions. http://purl.obolibrary.org/obo/CHEBI_33893 reagent http://purl.obolibrary.org/obo/CHEBI_33232 application A substance used in a chemical reaction to detect, measure, examine, or produce other substances. http://purl.obolibrary.org/obo/CHEBI_35195 surfactant http://purl.obolibrary.org/obo/CHEBI_63046 emulsifier A substance which lowers the surface tension of the medium in which it is dissolved, and/or the interfacial tension with other phases, and, accordingly, is positively adsorbed at the liquid/vapour and/or at other interfaces. http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor http://purl.obolibrary.org/obo/CHEBI_51086 chemical role A substance that diminishes the rate of a chemical reaction. http://purl.obolibrary.org/obo/CHEBI_35223 catalyst http://purl.obolibrary.org/obo/CHEBI_51086 chemical role A substance that increases the rate of a reaction without modifying the overall standard Gibbs energy change in the reaction. http://purl.obolibrary.org/obo/CHEBI_35224 effector http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role A small molecule which increases (activator) or decreases (inhibitor) the activity of an (allosteric) enzyme by binding to the enzyme at the regulatory site (which is different from the substrate-binding catalytic site). http://purl.obolibrary.org/obo/CHEBI_35225 buffer http://purl.obolibrary.org/obo/CHEBI_51086 chemical role Any substance or mixture of substances that, in solution (typically aqueous), resists change in pH upon addition of small amounts of acid or base. http://purl.obolibrary.org/obo/CHEBI_35337 central nervous system stimulant http://purl.obolibrary.org/obo/CHEBI_35470 central nervous system drug Any drug that enhances the activity of the central nervous system. http://purl.obolibrary.org/obo/CHEBI_35493 antipyretic http://purl.obolibrary.org/obo/CHEBI_35472 anti-inflammatory drug A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever. http://purl.obolibrary.org/obo/CHEBI_35497 androgen antagonist http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist A compound which inhibits or antagonises the biosynthesis or actions of androgens. http://purl.obolibrary.org/obo/CHEBI_35526 hypoglycemic agent http://purl.obolibrary.org/obo/CHEBI_23888 drug A drug which lowers the blood glucose level. http://purl.obolibrary.org/obo/CHEBI_35530 beta-adrenergic antagonist http://purl.obolibrary.org/obo/CHEBI_48540 beta-adrenergic drug An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety. http://purl.obolibrary.org/obo/CHEBI_35617 flavouring agent http://purl.obolibrary.org/obo/CHEBI_64047 food additive Substance added to foods and medicine to improve the quality of taste. http://purl.obolibrary.org/obo/CHEBI_35705 immunosuppressive agent http://purl.obolibrary.org/obo/CHEBI_50846 immunomodulator An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. http://purl.obolibrary.org/obo/CHEBI_35856 lipoxygenase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor A compound or agent that combines with lipoxygenase and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of the icosanoid products hydroxyicosatetraenoic acid and various leukotrienes. http://purl.obolibrary.org/obo/CHEBI_36335 trypanocidal drug http://purl.obolibrary.org/obo/CHEBI_35820 antiprotozoal drug A drug used to treat or prevent infections caused by protozoal organisms belonging to the suborder Trypanosomatida. http://purl.obolibrary.org/obo/CHEBI_38161 chelator http://purl.obolibrary.org/obo/CHEBI_52214 ligand A ligand with two or more separate binding sites that can bind to a single metallic central atom, forming a chelate. http://purl.obolibrary.org/obo/CHEBI_38231 phytotoxin http://purl.obolibrary.org/obo/CHEBI_27026 toxin Any toxin produced by a plant. http://purl.obolibrary.org/obo/CHEBI_38462 acetylcholinesterase inhibitor http://purl.obolibrary.org/obo/CHEBI_37733 cholinesterase inhibitor An enzyme inhibitor that inhibits the action of enzyme acetylcholinesterase (EC 3.1.1.7), which helps breaking down of acetylcholine into choline and acetic acid. http://purl.obolibrary.org/obo/CHEBI_38623 monoamine oxidase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor One of a chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. http://purl.obolibrary.org/obo/CHEBI_38633 sodium channel blocker http://purl.obolibrary.org/obo/CHEBI_39000 sodium channel modulator An agent that inhibits sodium influx through cell membranes. http://purl.obolibrary.org/obo/CHEBI_38869 general anaesthetic http://purl.obolibrary.org/obo/CHEBI_38867 anaesthetic Substance that produces loss of consciousness. http://purl.obolibrary.org/obo/CHEBI_48356 protic solvent http://purl.obolibrary.org/obo/CHEBI_48354 polar solvent A polar solvent that is capable of acting as a hydron (proton) donor. http://purl.obolibrary.org/obo/CHEBI_48578 radical scavenger http://purl.obolibrary.org/obo/CHEBI_22586 antioxidant A role played by a substance that can react readily with, and thereby eliminate, radicals. http://purl.obolibrary.org/obo/CHEBI_48705 agonist http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role Substance which binds to cell receptors normally responding to naturally occurring substances and which produces a response of its own. http://purl.obolibrary.org/obo/CHEBI_50141 bronchoconstrictor agent http://purl.obolibrary.org/obo/CHEBI_23888 drug A drug which causes a narrowing of the lumen of a bronchus or bronchiole. http://purl.obolibrary.org/obo/CHEBI_50177 dermatologic drug http://purl.obolibrary.org/obo/CHEBI_23888 drug A drug used to treat or prevent skin disorders or for the routine care of skin. http://purl.obolibrary.org/obo/CHEBI_50266 prodrug http://purl.obolibrary.org/obo/CHEBI_23888 drug A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug. http://purl.obolibrary.org/obo/CHEBI_50427 platelet aggregation inhibitor http://purl.obolibrary.org/obo/CHEBI_50248 hematologic agent A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. http://purl.obolibrary.org/obo/CHEBI_50503 laxative http://purl.obolibrary.org/obo/CHEBI_23888 drug An agent that produces a soft formed stool, and relax and loosen the bowels, typically used over a protracted period, to relieve constipation. Compare with cathartic, which is a substance that accelerates defecation. A substances can be both a laxatives and a cathartic. http://purl.obolibrary.org/obo/CHEBI_50509 potassium channel blocker http://purl.obolibrary.org/obo/CHEBI_50510 potassium channel modulator An agent that inhibits cell membrane glycoproteins that are selectively permeable to potassium ions. http://purl.obolibrary.org/obo/CHEBI_50683 dihydrofolate reductase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any compound that inhibits the action of dihydrofolate reductase (EC 1.5.1.3). http://purl.obolibrary.org/obo/CHEBI_50733 nutraceutical http://purl.obolibrary.org/obo/CHEBI_23888 drug A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance. http://purl.obolibrary.org/obo/CHEBI_50751 anti-estrogen http://purl.obolibrary.org/obo/CHEBI_23888 drug A drug which acts to reduce estrogenic activity in the body, either by reducing the amount of estrogen or by reducing the activity of whatever estrogen is present. http://purl.obolibrary.org/obo/CHEBI_50857 anti-allergic agent http://purl.obolibrary.org/obo/CHEBI_23888 drug A drug used to treat allergic reactions. http://purl.obolibrary.org/obo/CHEBI_50909 nephrotoxic agent http://purl.obolibrary.org/obo/CHEBI_52209 aetiopathogenetic role A role played by a chemical compound exihibiting itself through the ability to induce damage to the kidney in animals. http://purl.obolibrary.org/obo/CHEBI_51065 dopamine agonist http://purl.obolibrary.org/obo/CHEBI_48560 dopaminergic agent A drug that binds to and activates dopamine receptors. http://purl.obolibrary.org/obo/CHEBI_51217 fluorochrome http://purl.obolibrary.org/obo/CHEBI_51121 fluorescent dye A fluorescent dye used to stain biological specimens. http://purl.obolibrary.org/obo/CHEBI_51372 neuromuscular agent http://purl.obolibrary.org/obo/CHEBI_23888 drug A drug used for its actions on skeletal muscle. http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role http://purl.obolibrary.org/obo/CHEBI_24432 biological role A biological role played by the molecular entity or part thereof within a biochemical context. http://purl.obolibrary.org/obo/CHEBI_52217 pharmaceutical http://purl.obolibrary.org/obo/CHEBI_33232 application Any substance introduced into a living organism with therapeutic or diagnostic purpose. http://purl.obolibrary.org/obo/CHEBI_52290 mitogen http://purl.obolibrary.org/obo/CHEBI_24432 biological role A chemical substance that encourages a cell to commence cell division, triggering mitosis. http://purl.obolibrary.org/obo/CHEBI_52424 glycoside hydrolase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor A compound that inhibits glycosidases, enzymes which catalyze the hydrolysis of the glycosidic linkage to generate two smaller sugars. http://purl.obolibrary.org/obo/CHEBI_53121 adenosine A2A receptor antagonist http://purl.obolibrary.org/obo/CHEBI_71232 adenosine receptor antagonist An antagonist at the A2A receptor. http://purl.obolibrary.org/obo/CHEBI_59132 antigen http://purl.obolibrary.org/obo/CHEBI_24432 biological role Any substance that stimulates an immune response in the body, such as through antibody production or by presentation to a T-cell receptor after binding to a major histocompability complex (MHC). http://purl.obolibrary.org/obo/CHEBI_59997 tyrosinase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any inhibitor of tyrosinase (monophenol monooxygenase) (EC 1.14.18.1), an enzyme that catalyses the oxidation of phenols (such as tyrosine) and is widespread in plants and animals. http://purl.obolibrary.org/obo/CHEBI_60311 thyroid hormone http://purl.obolibrary.org/obo/CHEBI_24621 hormone Any hormone produced by the thyroid gland http://purl.obolibrary.org/obo/CHEBI_61016 angiotensin receptor antagonist http://purl.obolibrary.org/obo/CHEBI_62754 glycine receptor antagonist A hormone antagonist that blocks angiotensin receptors. http://purl.obolibrary.org/obo/CHEBI_62434 anaplastic lymphoma kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_38637 tyrosine kinase inhibitor An enzyme inhibitor that interferes with the action of anaplastic lymphoma kinase. http://purl.obolibrary.org/obo/CHEBI_62488 signalling molecule http://purl.obolibrary.org/obo/CHEBI_33280 molecular messenger A molecular messenger in which the molecule is specifically involved in transmitting information between cells. Such molecules are released from the cell sending the signal, cross over the gap between cells by diffusion, and interact with specific receptors in another cell, triggering a response in that cell by activating a series of enzyme controlled reactions which lead to changes inside the cell. http://purl.obolibrary.org/obo/CHEBI_63957 adenosine A1 receptor antagonist http://purl.obolibrary.org/obo/CHEBI_71232 adenosine receptor antagonist An antagonist at the A1 receptor. http://purl.obolibrary.org/obo/CHEBI_64033 arachidonoylethanolamide amidohydrolase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of arachidonoylethanolamide amidohydrolase. http://purl.obolibrary.org/obo/CHEBI_64571 NMDA receptor agonist http://purl.obolibrary.org/obo/CHEBI_50103 excitatory amino acid agonist An excitatory amino acid agonist which binds to NMDA receptors and triggers a response. http://purl.obolibrary.org/obo/CHEBI_64909 poison http://purl.obolibrary.org/obo/CHEBI_24432 biological role Any substance that causes disturbance to organisms by chemical reaction or other activity on the molecular scale, when a sufficient quantity is absorbed by the organism. http://purl.obolibrary.org/obo/CHEBI_64947 anti-HIV-1 agent http://purl.obolibrary.org/obo/CHEBI_64946 anti-HIV agent An anti-HIV agent that destroys or inhibits the replication of HIV-1, the more infective and more virulent of the two types of HIV virus. http://purl.obolibrary.org/obo/CHEBI_65255 food preservative http://purl.obolibrary.org/obo/CHEBI_64047 food additive Substances which are added to food in order to prevent decomposition by microbial growth or by undesirable chemical changes. http://purl.obolibrary.org/obo/CHEBI_65259 GABA antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist A compound that inhibits the action of gamma-aminobutyric acid. http://purl.obolibrary.org/obo/CHEBI_66900 prostaglandin receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist An agonist that binds to and activates prostaglandin receptors. http://purl.obolibrary.org/obo/CHEBI_67114 ryanodine receptor agonist http://purl.obolibrary.org/obo/CHEBI_38809 ryanodine receptor modulator A ryanodine receptor modulator which activates the receptor. Ryanodine receptors (RyRs) act as selective ion channels, modulating the release of calcium. Activating the receptors causes the release of calcium, so depleting internal calcium and ultimately preventing further muscle contraction. http://purl.obolibrary.org/obo/CHEBI_67232 oligo-1,6-glucosidase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits the action of sucrose oligo-1,6-glucosidase (EC 3.2.1.10). http://purl.obolibrary.org/obo/CHEBI_67239 alpha-glucosidase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits the action of alpha-glucosidase (EC 3.2.1.20). http://purl.obolibrary.org/obo/CHEBI_70722 acetyl-CoA carboxylase inhibitor http://purl.obolibrary.org/obo/CHEBI_75604 C-C bond-forming ligase inhibitor An enzyme inhibitor that inhibits the action of acetyl-CoA carboxylase (EC 6.4.1.2). http://purl.obolibrary.org/obo/CHEBI_70727 topoisomerase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits the action of any of the topoisomerases (enzymes that regulate the overwinding or underwinding of DNA). http://purl.obolibrary.org/obo/CHEBI_70774 capsaicin receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist Any substance which blocks the painful sensation of heat caused by capsaicin acting on the TRPV1 ion channel. http://purl.obolibrary.org/obo/CHEBI_70782 PPARalpha agonist http://purl.obolibrary.org/obo/CHEBI_70781 PPAR modulator A PPAR modulator which activates the peroxisome proliferator-activated receptor-alpha. http://purl.obolibrary.org/obo/CHEBI_70868 antileishmanial agent http://purl.obolibrary.org/obo/CHEBI_35820 antiprotozoal drug An antiprotozoal drug used to treat or prevent infections caused by protozoan parasites that belong to the genus Leishmania. http://purl.obolibrary.org/obo/CHEBI_71692 insect repellent http://purl.obolibrary.org/obo/CHEBI_24852 insecticide An insecticide that acts as a repellent to insects. http://purl.obolibrary.org/obo/CHEBI_73192 protoporphyrinogen oxidase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits the action of protoporphyrinogen oxidase, EC 1.3.3.4. http://purl.obolibrary.org/obo/CHEBI_73216 acid anhydride hydrolase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits the action of any hydrolase that acts on an acid anhydride (EC 3.6.*.*). http://purl.obolibrary.org/obo/CHEBI_73240 NF-kappaB inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor An inhibitor of NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells), a protein complex involved in the transcription of DNA. http://purl.obolibrary.org/obo/CHEBI_73311 adenosine receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist An agonist at any adenosine receptor. http://purl.obolibrary.org/obo/CHEBI_73335 ultraviolet filter http://purl.obolibrary.org/obo/CHEBI_52215 photochemical role A photochemical role realized in the absorption of ultraviolet light, for example to protect skin cells from damage. http://purl.obolibrary.org/obo/CHEBI_74152 mordant http://purl.obolibrary.org/obo/CHEBI_33232 application Substance used to set dyes on fabrics or tissue sections by forming a coordination complex with the dye which then attaches to the fabric or tissue. http://purl.obolibrary.org/obo/CHEBI_74440 epidermal growth factor receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist An antagonist at the epidermal growth factor receptor. http://purl.obolibrary.org/obo/CHEBI_74518 anti-obesity agent http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role Any substance which is used to reduce or control weight. http://purl.obolibrary.org/obo/CHEBI_75047 B-Raf inhibitor http://purl.obolibrary.org/obo/CHEBI_50925 non-specific serine/threonine protein kinase inhibitor A serine/threonine kinase inhibitor that specifically inhibits human mutant serine/threonine kinase (B-Raf) http://purl.obolibrary.org/obo/CHEBI_75768 mammalian metabolite http://purl.obolibrary.org/obo/CHEBI_75767 animal metabolite Any animal metabolite produced during a metabolic reaction in mammals. http://purl.obolibrary.org/obo/CHEBI_75769 B vitamin http://purl.obolibrary.org/obo/CHEBI_27314 water-soluble vitamin Any of the group of eight water-soluble vitamins originally thought to be a single compound (vitamin B) that play important roles in cell metabolism. The group comprises vitamin B1, B2, B3, B5, B6, B7, B9, and B12. (Around 20 other compounds were once thought to be B vitamins but are no longer classified as such.) http://purl.obolibrary.org/obo/CHEBI_20854 ATP synthase inhibitor http://purl.obolibrary.org/obo/CHEBI_25355 mitochondrial respiratory-chain inhibitor A mitochondrial respiratory-chain inhibitor that interferes with the action of ATP synthase. http://purl.obolibrary.org/obo/CHEBI_22582 antibiotic http://purl.obolibrary.org/obo/CHEBI_33281 antimicrobial agent A substance that is biostatic or biocidal at low concentrations towards bacteria, yeasts, moulds, or other form of life, especially pathogenic or noxious organisms. Although the term was originally restricted to substances produced by microorganisms, its use was later expanded to include derivatives of such substances and it is now commonly used to include entirely synthetic compounds. http://purl.obolibrary.org/obo/CHEBI_23092 chemosterilant http://purl.obolibrary.org/obo/CHEBI_25944 pesticide A substance intended to sterilize any organism. http://purl.obolibrary.org/obo/CHEBI_23582 defoliant http://purl.obolibrary.org/obo/CHEBI_24527 herbicide A herbicide which when sprayed or dusted on plants causes its leaves to fall off. http://purl.obolibrary.org/obo/CHEBI_24432 biological role http://purl.obolibrary.org/obo/CHEBI_50906 role A role played by the molecular entity or part thereof within a biological context. http://purl.obolibrary.org/obo/CHEBI_24850 insect attractant http://purl.obolibrary.org/obo/CHEBI_25944 pesticide A chemical that lures insects to a trap, thereby removing them from crops, animals or stored products. http://purl.obolibrary.org/obo/CHEBI_24851 insect growth regulator http://purl.obolibrary.org/obo/CHEBI_39317 growth regulator A growth regulator that inhibits the life cycle of an insect. http://purl.obolibrary.org/obo/CHEBI_24853 intercalator http://purl.obolibrary.org/obo/CHEBI_25435 mutagen A role played by a chemical agent which exhibits the capability of occupying space between DNA base pairs due to particular properties in size, shape and charge. Intercalation of chemical compounds in DNA helix can result in replication errors (shift, mutation) or DNA damages. http://purl.obolibrary.org/obo/CHEBI_24869 ionophore http://purl.obolibrary.org/obo/CHEBI_38632 membrane transport modulator A compound which can carry specific ions through membranes of cells or organelles. http://purl.obolibrary.org/obo/CHEBI_25573 nodulation factor http://purl.obolibrary.org/obo/CHEBI_24432 biological role A role played by signal molecules produced by the symbiotic bacteria that trigger nodule formation (typically on the host plant roots). http://purl.obolibrary.org/obo/CHEBI_25943 pesticide synergist http://purl.obolibrary.org/obo/CHEBI_25944 pesticide A substance that increases the efficacy of a pesticide. http://purl.obolibrary.org/obo/CHEBI_25944 pesticide http://purl.obolibrary.org/obo/CHEBI_33232 application Strictly, a substance intended to kill pests. In common usage, any substance used for controlling, preventing, or destroying animal, microbiological or plant pests. http://purl.obolibrary.org/obo/CHEBI_26619 secondary metabolite http://purl.obolibrary.org/obo/CHEBI_25212 metabolite A metabolite that is not directly involved in the normal growth, development or reproduction of an organism. http://purl.obolibrary.org/obo/CHEBI_33232 application http://purl.obolibrary.org/obo/CHEBI_50906 role Intended use of the molecular entity or part thereof by humans. http://purl.obolibrary.org/obo/CHEBI_33904 molluscicide http://purl.obolibrary.org/obo/CHEBI_25944 pesticide A substance used to destroy pests of the phylum Mollusca. http://purl.obolibrary.org/obo/CHEBI_35204 tracer http://purl.obolibrary.org/obo/CHEBI_33232 application A role played by a foreign substance mixed with or attached to a given substance to enable the distribution or location of the latter to be determined subsequently. http://purl.obolibrary.org/obo/CHEBI_35499 hallucinogen http://purl.obolibrary.org/obo/CHEBI_35471 psychotropic drug Drugs capable of inducing illusions, hallucinations, delusions, paranoid ideations and other alterations of mood and thinking. http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function. http://purl.obolibrary.org/obo/CHEBI_37670 protease inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor A compound which inhibits or antagonizes the biosynthesis or actions of proteases (endopeptidases). http://purl.obolibrary.org/obo/CHEBI_38155 phytosiderophore http://purl.obolibrary.org/obo/CHEBI_24874 iron ionophore Any of low-molecular-mass iron(III)-chelating compounds produced by plants for the purpose of the transport and sequestration of iron. http://purl.obolibrary.org/obo/CHEBI_38461 carbamate insecticide http://purl.obolibrary.org/obo/CHEBI_38462 acetylcholinesterase inhibitor Derivatives of carbamic acid with insecticidal properties of general formula ROC(=O)NR(1)R(2), where ROH is an alcohol, oxime, or phenol and R(1) is hydrogen or methyl. Like organophosphate insecticides, they are cholinesterase inhibitors, but carbamate insecticides differ in action from the organophosphates in that the inhibitory effect on cholinesterase is generally brief. http://purl.obolibrary.org/obo/CHEBI_38632 membrane transport modulator http://purl.obolibrary.org/obo/CHEBI_52208 biophysical role Any agent that affects the transport of molecular entities across a biological membrane. http://purl.obolibrary.org/obo/CHEBI_39141 Bronsted acid http://purl.obolibrary.org/obo/CHEBI_37527 acid A molecular entity capable of donating a hydron to an acceptor (Bronsted base). http://purl.obolibrary.org/obo/CHEBI_39317 growth regulator http://purl.obolibrary.org/obo/CHEBI_24432 biological role Any chemical substance that inhibits the life-cycle of an organism. http://purl.obolibrary.org/obo/CHEBI_49200 proton pump inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor A compound that inhibits H(+)--K(+)-exchanging ATPase. http://purl.obolibrary.org/obo/CHEBI_50627 alpha-amylase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of alpha-amylase (EC 3.2.1.1). http://purl.obolibrary.org/obo/CHEBI_50949 serotonin uptake inhibitor http://purl.obolibrary.org/obo/CHEBI_50184 ion transport inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. http://purl.obolibrary.org/obo/CHEBI_51087 protecting group http://purl.obolibrary.org/obo/CHEBI_33232 application A group that is introduced into a molecule by chemical modification of a functional group in order to obtain chemoselectivity in a subsequent chemical reaction. http://purl.obolibrary.org/obo/CHEBI_52216 photobiochemical role http://purl.obolibrary.org/obo/CHEBI_52215 photochemical role A role played by a molecular entity or part thereof in a photobiochemical process. http://purl.obolibrary.org/obo/CHEBI_59672 chitin synthase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any compound that inhibits the action of chitin synthase (EC 2.4.1.16). http://purl.obolibrary.org/obo/CHEBI_59739 electrophilic reagent http://purl.obolibrary.org/obo/CHEBI_39143 Lewis acid A reagent that forms a bond to its reaction partner (the nucleophile) by accepting both bonding electrons from that reaction partner. http://purl.obolibrary.org/obo/CHEBI_60688 tryptophan synthase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any compound that inhibits the action of tryptophan synthase. http://purl.obolibrary.org/obo/CHEBI_60788 affinity label http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor, generally irreversible, that is similar in structure to a particular substrate for a specific enzyme. http://purl.obolibrary.org/obo/CHEBI_61015 nephrotoxin http://purl.obolibrary.org/obo/CHEBI_64909 poison A poison that interferes with the function of the kidneys. http://purl.obolibrary.org/obo/CHEBI_64152 cysteine protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670 protease inhibitor Any protease inhibitor that restricts the action of a cysteine protease. http://purl.obolibrary.org/obo/CHEBI_64912 antimycobacterial drug http://purl.obolibrary.org/obo/CHEBI_36047 antibacterial drug A drug used to treat or prevent infections caused by Mycobacteria, a genus of actinobacteria. Aerobic and nonmotile, members of the genus include the pathogens responsible for causing tuberculosis and leprosy. http://purl.obolibrary.org/obo/CHEBI_64953 anti-HSV-1 agent http://purl.obolibrary.org/obo/CHEBI_64952 anti-HSV agent An anti-HSV agent agent that destroys or inhibits the replication of herpes simplex virus-1. http://purl.obolibrary.org/obo/CHEBI_67105 insect sterilant http://purl.obolibrary.org/obo/CHEBI_23092 chemosterilant A chemosterilant intended to sterilize insects. http://purl.obolibrary.org/obo/CHEBI_71178 N-acetylserotonin methyltransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of N-acetylserotonin methyltransferase (EC 2.1.1.4) http://purl.obolibrary.org/obo/CHEBI_73191 abscisic acid receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist An agonist that binds to and activates abscisic acid receptors. http://purl.obolibrary.org/obo/CHEBI_73214 H(+)-transporting two-sector ATPase inhibitor http://purl.obolibrary.org/obo/CHEBI_73216 acid anhydride hydrolase inhibitor Any acid anhydride hydrolase inhibitor that inhibits the action of H(+)-transporting two-sector ATPase inhibitor, EC 3.6.3.14. http://purl.obolibrary.org/obo/CHEBI_73966 nitric oxide synthase activator http://purl.obolibrary.org/obo/CHEBI_35224 effector An effector that binds to and activates the enzyme nitric oxide synthase (EC 1.14.13.39) http://purl.obolibrary.org/obo/CHEBI_37334 diagnostic imaging agent http://purl.obolibrary.org/obo/CHEBI_33295 diagnostic agent A substance administered to enhance contrast in images of the inside of the body obtained using X-rays, gamma-rays, sound waves, radio waves (MRI), or radioactive particles in order to diagnose disease. http://purl.obolibrary.org/obo/CHEBI_37845 growth hormone http://purl.obolibrary.org/obo/CHEBI_24621 hormone A hormone that specifically regulates growth. http://purl.obolibrary.org/obo/CHEBI_37961 H2-receptor antagonist http://purl.obolibrary.org/obo/CHEBI_37956 histamine antagonist H2-receptor antagonists are the drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of endogenous histamine. http://purl.obolibrary.org/obo/CHEBI_38503 NADH:ubiquinone reductase inhibitor http://purl.obolibrary.org/obo/CHEBI_38497 respiratory-chain inhibitor A respiratory-chain inhibitor that interferes with the action of the the enzyme NADH:ubiquinone reductase (EC 1.6.5.3) http://purl.obolibrary.org/obo/CHEBI_38828 nonionic surfactant http://purl.obolibrary.org/obo/CHEBI_35195 surfactant A surfactant with an uncharged hydrophilic headgroup. http://purl.obolibrary.org/obo/CHEBI_38849 blood substitute http://purl.obolibrary.org/obo/CHEBI_52217 pharmaceutical A substance that can carry oxygen to and carbon dioxide away from the tissues when introduced into the blood stream. Blood substitutes are used to replace hemoglobin in severe hemorrhage and also to perfuse isolated organs. http://purl.obolibrary.org/obo/CHEBI_39011 Good's buffer substance http://purl.obolibrary.org/obo/CHEBI_35225 buffer Any member of a collection of zwitterionic buffer substances selected or devised for suitability in experimental biological systems according to a number of predetermined criteria. Named after Dr. Norman Good. http://purl.obolibrary.org/obo/CHEBI_39142 Bronsted base http://purl.obolibrary.org/obo/CHEBI_22695 base A molecular entity capable of accepting a hydron from a donor (Bronsted acid). http://purl.obolibrary.org/obo/CHEBI_39144 Lewis base http://purl.obolibrary.org/obo/CHEBI_22695 base A molecular entity able to provide a pair of electrons and thus capable of forming a covalent bond with an electron-pair acceptor (Lewis acid), thereby producing a Lewis adduct. http://purl.obolibrary.org/obo/CHEBI_49205 CETP inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role Any inhibitor of cholesterylester transfer protein (CETP), which transfers cholesterol from high density lipoproteins (HDL, the 'good' cholesterol-containing particles) to low or very low density lipoproteins (LDL or VLDL, the 'bad' cholesterol-containing particles). Inhibition of this process results in higher HDL levels and lower LDL levels. CETP inhibitors are under investigation as potential drugs to reduce the risk of arteriosclerotic vascular disease (atherosclerosis). http://purl.obolibrary.org/obo/CHEBI_59897 reverse transcriptase inhibitor http://purl.obolibrary.org/obo/CHEBI_22587 antiviral agent An entity which inhibits the activity of reverse transcriptase, a viral DNA polymerase enzyme that retroviruses need to reproduce. http://purl.obolibrary.org/obo/CHEBI_60258 peptidase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any inhibitor of a peptidase. http://purl.obolibrary.org/obo/CHEBI_63114 sphingosine-1-phosphate receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist An agonist that binds to and activates sphingosine 1-phosphate receptors. http://purl.obolibrary.org/obo/CHEBI_63173 T-cell proliferation inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor An inhibitor that interferes with the process of T-cell proliferation. http://purl.obolibrary.org/obo/CHEBI_63962 Hsp90 inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor An inhibitor that blocks the action of heat shock protein 90. http://purl.obolibrary.org/obo/CHEBI_68563 P2Y12 receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist An antagonist at the P2Y12 receptor http://purl.obolibrary.org/obo/CHEBI_48668 gamma-secretase modulator http://purl.obolibrary.org/obo/CHEBI_35224 effector A modulator of gamma secretase, one of the three endopeptidases that are specific for amyloid protein precursor and which have been identified based upon the region of the amyloid protein precursor which they cleave. http://purl.obolibrary.org/obo/CHEBI_49324 female contraceptive drug http://purl.obolibrary.org/obo/CHEBI_49323 contraceptive drug A chemical substance or agent with contraceptive activity in females. http://purl.obolibrary.org/obo/CHEBI_49325 oral contraceptive http://purl.obolibrary.org/obo/CHEBI_49324 female contraceptive drug A compound, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. http://purl.obolibrary.org/obo/CHEBI_50112 sex hormone http://purl.obolibrary.org/obo/CHEBI_24621 hormone Any hormone that is responsible for controlling sexual characteristics and reproductive function. http://purl.obolibrary.org/obo/CHEBI_50242 enzyme reactivator http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role Compound which restore enzymatic activity by removing an inhibitory group bound to the reactive site of the enzyme. http://purl.obolibrary.org/obo/CHEBI_50382 ceramide glucosyltransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits the activity of ceramide glucosyltransferase (EC 2.4.1.80). http://purl.obolibrary.org/obo/CHEBI_50408 visual indicator http://purl.obolibrary.org/obo/CHEBI_47867 indicator Anything used in a scientific experiment that gives a visual change to indicate the presence of a substance or quality, change in a body, etc. http://purl.obolibrary.org/obo/CHEBI_50409 adsorption indicator http://purl.obolibrary.org/obo/CHEBI_50408 visual indicator A substance which is adsorbed or desorbed with concomitant colour change at or near the equivalence point of a titration. http://purl.obolibrary.org/obo/CHEBI_50411 one-colour indicator http://purl.obolibrary.org/obo/CHEBI_50410 colour indicator A colour indicator that is colourless on one side of the transition interval. http://purl.obolibrary.org/obo/CHEBI_50433 platelet glycoprotein-IIb/IIIa receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist Antagonist of platelet surface glycoprotein-IIb/IIIa which has a key role in hemostasis and thrombosis such as platelet adhesion and aggregation. http://purl.obolibrary.org/obo/CHEBI_50685 antitrichomonal drug http://purl.obolibrary.org/obo/CHEBI_35820 antiprotozoal drug A drug used to treat trichomonas infections. http://purl.obolibrary.org/obo/CHEBI_50689 reproductive control drug http://purl.obolibrary.org/obo/CHEBI_23888 drug A substance used either in the prevention or facilitation of pregnancy. http://purl.obolibrary.org/obo/CHEBI_50779 appetite enhancer http://purl.obolibrary.org/obo/CHEBI_50780 appetite regulator A drug which increases appetite. http://purl.obolibrary.org/obo/CHEBI_50827 antiparathyroid drug http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist A drug used to treat hyperparathyroidism by reducing the excessive production of parathyroid hormones. http://purl.obolibrary.org/obo/CHEBI_50843 antimineralocorticoid http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist A compound which inhibits or antagonizes the biosynthesis or actions of mineralocorticoids, a class of steroid hormones characterised by their similarity to aldosterone and their influence on salt and water balance. http://purl.obolibrary.org/obo/CHEBI_50907 deaminating agent http://purl.obolibrary.org/obo/CHEBI_51086 chemical role A deaminating agent is a role played by a chemical agent which exhibits the capability of causing the loss of an amine functional group on another molecular entity (e.g. DNA or protein). http://purl.obolibrary.org/obo/CHEBI_50914 phosphatidylinositol-3-OH kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_50916 lipid kinase inhibitor An inhibitor of phosphatidylinositol-3-OH kinases, a family of related enzymes capable of phosphorylating the 3 position hydroxy group of the inositol ring of a phosphatidylinositol. http://purl.obolibrary.org/obo/CHEBI_50916 lipid kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An agent that inhibits lipid kinases. http://purl.obolibrary.org/obo/CHEBI_52209 aetiopathogenetic role http://purl.obolibrary.org/obo/CHEBI_24432 biological role A role played by the molecular entity or part thereof which causes the development of a pathological process. http://purl.obolibrary.org/obo/CHEBI_55351 substance P receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist An antagonist at the substance P receptor. http://purl.obolibrary.org/obo/CHEBI_60599 mu-opioid agent http://purl.obolibrary.org/obo/CHEBI_60598 opioid agent Any agent that acts on a mu-opioid receptor. http://purl.obolibrary.org/obo/CHEBI_60605 opioid receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist An agent that binds to but does not activate an opioid receptor thereby blocking the actions of endogenous or exogenous opioid receptor agonists. http://purl.obolibrary.org/obo/CHEBI_70728 actin polymerisation inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor Any substance that inhibits the polymerisation of the protein actin. http://purl.obolibrary.org/obo/CHEBI_70781 PPAR modulator http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role Any compound which acts on the peroxisome proliferator-activated receptor. http://purl.obolibrary.org/obo/CHEBI_73361 methionine aminopeptidase 2 inhibitor http://purl.obolibrary.org/obo/CHEBI_73360 methionyl aminopeptidase inhibitor Any methionyl aminopeptidase inhibitor that inhibits the action of methionyl aminopeptidase 2. http://purl.obolibrary.org/obo/CHEBI_73913 antifolate http://purl.obolibrary.org/obo/CHEBI_35221 antimetabolite An antimetabolite that impairs the action of folic acids http://purl.obolibrary.org/obo/CHEBI_75190 lysine 2,3-aminomutase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of lysine 2,3-aminomutase. http://purl.obolibrary.org/obo/CHEBI_60280 glutaminase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any compound that inhibits the activity of a glutaminase and thus the generation of glutamate from glutamine http://purl.obolibrary.org/obo/CHEBI_60593 conazole fungicide http://purl.obolibrary.org/obo/CHEBI_24127 fungicide A member of a class of fungicides that contains an imidazole or triazole moiety. http://purl.obolibrary.org/obo/CHEBI_60598 opioid agent http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent Any agent that acts on an opioid receptor or affects the life cycle of an opioid transmitter. http://purl.obolibrary.org/obo/CHEBI_60644 bridged diphenyl fungicide http://purl.obolibrary.org/obo/CHEBI_24127 fungicide Any member of the class of fungicides whose members contain two phenyl (or substituted phenyl) groups attached to a single carbon or heteratom. http://purl.obolibrary.org/obo/CHEBI_60646 chiral reagent http://purl.obolibrary.org/obo/CHEBI_33893 reagent A chiral compound used to induce stereoselectivity into a reaction. http://purl.obolibrary.org/obo/CHEBI_60649 glucagon receptor antagonist http://purl.obolibrary.org/obo/CHEBI_62754 glycine receptor antagonist An agent which blocks glucagon receptors. http://purl.obolibrary.org/obo/CHEBI_60797 NMDA receptor antagonist http://purl.obolibrary.org/obo/CHEBI_63963 metabotropic glutamate receptor antagonist Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs. http://purl.obolibrary.org/obo/CHEBI_60798 excitatory amino acid antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist Any substance which inhibits the action of receptors for excitatory amino acids. http://purl.obolibrary.org/obo/CHEBI_61026 bile therapy drug http://purl.obolibrary.org/obo/CHEBI_23888 drug A drug used in the treatment of bile or liver disorders. http://purl.obolibrary.org/obo/CHEBI_61774 inositol phosphorylceramide synthase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits the action of inositol phosphorylceramide synthase. http://purl.obolibrary.org/obo/CHEBI_62530 sphingosine N-acyltransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any inhibitor of sphingosine N-acyltransferase, EC 2.3.1.24. http://purl.obolibrary.org/obo/CHEBI_62670 phosphoprotein phosphatase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any inhibitor of phosphoprotein phosphatase, EC 3.1.3.16. http://purl.obolibrary.org/obo/CHEBI_62915 sialyltransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor A compound that inhibits the action of a sialyltransferase. http://purl.obolibrary.org/obo/CHEBI_62966 cytochrome c oxidase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of cytochrome c oxidase. http://purl.obolibrary.org/obo/CHEBI_63064 crystallisation adjutant http://purl.obolibrary.org/obo/CHEBI_51086 chemical role Chemical role played by a material when used to promote crystallisation. http://purl.obolibrary.org/obo/CHEBI_63146 insulin release inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor Any substance that inhibits the release of insulin http://purl.obolibrary.org/obo/CHEBI_63175 peptidomimetic http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role A small protein-like chain designed to mimic a peptide. http://purl.obolibrary.org/obo/CHEBI_63457 fibroblast growth factor receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist An antagonist at the fibroblast growth factor receptor. http://purl.obolibrary.org/obo/CHEBI_63673 chemokine receptor 5 antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist An antogonist that blocks chemokine receptor 5 (CCR5). http://purl.obolibrary.org/obo/CHEBI_63720 thymidylate synthase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any compound that inhibits the action of thymidylate synthase. http://purl.obolibrary.org/obo/CHEBI_63721 glycinamide ribonucleotide formyltransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any compound that inhibits the action of glycinamide ribonucleotide formyltransferase. http://purl.obolibrary.org/obo/CHEBI_63908 film-forming compound http://purl.obolibrary.org/obo/CHEBI_51086 chemical role Any compound that leaves a pliable, cohesive, and continuous covering over a surface when applied to it. http://purl.obolibrary.org/obo/CHEBI_63936 alpha1B-adrenoceptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist An antagonist at the alpha1B-adrenoceptor. http://purl.obolibrary.org/obo/CHEBI_63951 estrogen receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist An agonist at the estrogen receptor. http://purl.obolibrary.org/obo/CHEBI_64088 incretin mimetic http://purl.obolibrary.org/obo/CHEBI_24432 biological role Any compound that mimics the action of incretins, gastrointestinal hormones that cause an increase in the amount of insulin released from the beta cells of the islets of Langerhans after eating, even before blood glucose levels become elevated. http://purl.obolibrary.org/obo/CHEBI_64105 protein kinase G agonist http://purl.obolibrary.org/obo/CHEBI_64106 protein kinase agonist An agonist that selectively binds to and activates a protein kinase G receptor. http://purl.obolibrary.org/obo/CHEBI_64106 protein kinase agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist An agonist that selectively binds to and activates a protein kinase receptor. http://purl.obolibrary.org/obo/CHEBI_68542 dihydroorotate dehydrogenase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of dihydroorotate dehydrogenase (EC 1.3.3.1). http://purl.obolibrary.org/obo/CHEBI_68543 pyrimidine synthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits the synthesis of pyrimidine. http://purl.obolibrary.org/obo/CHEBI_71196 glucagon-like peptide-1 receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist An agonist that binds to and activates glucagon-like peptide-1 (GLP-1) receptors. http://purl.obolibrary.org/obo/CHEBI_73416 CB1 receptor antagonist http://purl.obolibrary.org/obo/CHEBI_73413 cannabinoid receptor antagonist An antagonist that binds to and deactivates type 1 cannabinoid receptors. http://purl.obolibrary.org/obo/CHEBI_70724 cell dedifferentiation agent http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role Any compound which induces a partially or terminally differentiated cell to revert to an earlier developmental stage. http://purl.obolibrary.org/obo/CHEBI_70725 adenosine A3 receptor antagonist http://purl.obolibrary.org/obo/CHEBI_71232 adenosine receptor antagonist An antagonist at the A3 receptor. http://purl.obolibrary.org/obo/CHEBI_70817 glyceraldehyde-3-phosphate dehydrogenase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) http://purl.obolibrary.org/obo/CHEBI_70982 reactive oxygen species generator http://purl.obolibrary.org/obo/CHEBI_51086 chemical role Any entity used to generate reactive oxygen species. http://purl.obolibrary.org/obo/CHEBI_71014 AMPA receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist An antagonist at the AMPA receptor. http://purl.obolibrary.org/obo/CHEBI_71027 progesterone receptor modulator http://purl.obolibrary.org/obo/CHEBI_51061 hormone receptor modulator A hormone receptor modulator that acts as a complete or partial agonist or as an antagonist at the progesterone receptor. http://purl.obolibrary.org/obo/CHEBI_71033 carbamylphosphate synthetase I activator http://purl.obolibrary.org/obo/CHEBI_35224 effector An effector that binds and activates the enzyme carbamylphosphate synthetase I http://purl.obolibrary.org/obo/CHEBI_72771 breast cancer resistance protein inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role Any inhibitor of breast cancer resistance protein (ABCG2). http://purl.obolibrary.org/obo/CHEBI_71551 acid ceramidase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of acid ceramidase. http://purl.obolibrary.org/obo/CHEBI_71554 PPARgamma agonist http://purl.obolibrary.org/obo/CHEBI_70781 PPAR modulator A PPAR modulator which activates the peroxisome proliferator-activated receptor-gamma. http://purl.obolibrary.org/obo/CHEBI_72298 MTP inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role An inhibitor that interferes with the action of MTP. http://purl.obolibrary.org/obo/CHEBI_72311 glucagon-like peptide-2 receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist An agonist that binds to and activates glucagon-like peptide-2 (GLP-2) receptors. http://purl.obolibrary.org/obo/CHEBI_73189 brassinosteroid biosynthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor Any compound that inhibits one or more steps in the pathway leading to the synthesis of brassinosteroids. http://purl.obolibrary.org/obo/CHEBI_73193 gibberellin biosynthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor Any compound that inhibits one or more steps in the pathway leading to the synthesis of gibberellins. http://purl.obolibrary.org/obo/CHEBI_73273 sodium-glucose transport protein subtype 2 inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role An inhibitor that interferes with the action of sodium-glucose transport protein subtype 2. http://purl.obolibrary.org/obo/CHEBI_73310 adenosine A2A receptor agonist http://purl.obolibrary.org/obo/CHEBI_73311 adenosine receptor agonist An agonist at the A2A receptor. http://purl.obolibrary.org/obo/CHEBI_73319 adenosine A3 receptor agonist http://purl.obolibrary.org/obo/CHEBI_73311 adenosine receptor agonist An agonist at the adenosine A3 receptor. http://purl.obolibrary.org/obo/CHEBI_73334 thyroid hormone agonist http://purl.obolibrary.org/obo/CHEBI_51060 hormone agonist A hormone agonist that binds to and activates a thyroid hormone receptor. http://purl.obolibrary.org/obo/CHEBI_73360 methionyl aminopeptidase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any enzyme inhibitor that inhibits the action of methionyl aminopeptidase (EC 3.4.11.18). http://purl.obolibrary.org/obo/CHEBI_73413 cannabinoid receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist An antagonist that binds to and deactivates cannabinoid receptors. http://purl.obolibrary.org/obo/CHEBI_73417 CB2 receptor antagonist http://purl.obolibrary.org/obo/CHEBI_73413 cannabinoid receptor antagonist An antagonist that binds to and deactivates type 2 cannabinoid receptors. http://purl.obolibrary.org/obo/CHEBI_75381 peroxidases inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits any of the peroxidases (EC 1.11.1.*). http://purl.obolibrary.org/obo/MP_0000003 abnormal adipose tissue morphology http://purl.obolibrary.org/obo/MP_0005375 adipose tissue phenotype any structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue http://purl.obolibrary.org/obo/MP_0000005 increased brown adipose tissue amount http://purl.obolibrary.org/obo/MP_0001778 abnormal brown adipose tissue amount increased amount of the thermogenic form of adipose tissue that is composed of brown adipocytes http://purl.obolibrary.org/obo/MP_0000008 increased white adipose tissue amount http://purl.obolibrary.org/obo/MP_0001781 abnormal white adipose tissue amount increased quantity of fat-storing cells/tissue http://purl.obolibrary.org/obo/MP_0000010 abnormal abdominal fat pad morphology http://purl.obolibrary.org/obo/MP_0005334 abnormal fat pad morphology any structural anomaly of the encapsulated adipose tissue in the abdomen http://purl.obolibrary.org/obo/MP_0000013 abnormal adipose tissue distribution http://purl.obolibrary.org/obo/MP_0000003 abnormal adipose tissue morphology alterations in the normal placement of body fat http://purl.obolibrary.org/obo/MP_0000015 abnormal ear pigmentation http://purl.obolibrary.org/obo/MP_0002177 abnormal outer ear morphology anomaly in the coloration of the skin of the outer ear due to changes in the amount, shape, or distribution of cells producing pigment http://purl.obolibrary.org/obo/MP_0000017 big ears http://purl.obolibrary.org/obo/MP_0002177 abnormal outer ear morphology outer ears of a greater than normal size http://purl.obolibrary.org/obo/MP_0000018 small ears http://purl.obolibrary.org/obo/MP_0002177 abnormal outer ear morphology outer ears of a smaller than normal size http://purl.obolibrary.org/obo/MP_0000019 thick ears http://purl.obolibrary.org/obo/MP_0002177 abnormal outer ear morphology increased width of the epidermal and cartilaginous tissue that makes up the ear http://purl.obolibrary.org/obo/MP_0000020 scaly ears http://purl.obolibrary.org/obo/MP_0002177 abnormal outer ear morphology ears covered with shedding scales or flakes http://purl.obolibrary.org/obo/MP_0000021 prominent ears http://purl.obolibrary.org/obo/MP_0000023 abnormal ear distance/ position protuberant outer ears http://purl.obolibrary.org/obo/MP_0000022 abnormal ear shape http://purl.obolibrary.org/obo/MP_0002177 abnormal outer ear morphology any anomaly in the characteristic surface outline or contour of the external ear http://purl.obolibrary.org/obo/MP_0000023 abnormal ear distance/ position http://purl.obolibrary.org/obo/MP_0002177 abnormal outer ear morphology anomaly in the space between or the placement of the outer ears http://purl.obolibrary.org/obo/MP_0000024 lowered ear position http://purl.obolibrary.org/obo/MP_0000023 abnormal ear distance/ position outer ears are situated below the normal location often giving the perception of protruding from the head http://purl.obolibrary.org/obo/MP_0000025 otic hypertelorism http://purl.obolibrary.org/obo/MP_0000023 abnormal ear distance/ position greater than normal space between the outer ears http://purl.obolibrary.org/obo/MP_0000026 abnormal inner ear morphology http://purl.obolibrary.org/obo/MP_0002102 abnormal ear morphology any structural anomaly of any components of the labyrinth, including the semicircular canals, vestibule and cochlea http://purl.obolibrary.org/obo/MP_0000028 abnormal pars superior vestibularis morphology http://purl.obolibrary.org/obo/MP_0002856 abnormal vestibular ganglion morphology any structural anomaly in the part of the vestibular ganglion that receives fibers from the maculae of the utricle and the sacculae and the ampullae of the anterior and lateral semicircular ducts http://purl.obolibrary.org/obo/MP_0000029 abnormal malleus morphology http://purl.obolibrary.org/obo/MP_0005105 abnormal middle ear ossicle morphology any structural anomaly of the largest of the three auditory ossicles, which resembles a club or hammer http://purl.obolibrary.org/obo/MP_0000030 abnormal tympanic ring morphology http://purl.obolibrary.org/obo/MP_0000049 abnormal middle ear morphology any structural anomaly of the bony ring at the ear canal to which the tympanic membrane is attached http://purl.obolibrary.org/obo/MP_0000031 abnormal cochlea morphology http://purl.obolibrary.org/obo/MP_0000026 abnormal inner ear morphology any structural anomaly of the spiral-shaped bony canal in the inner ear containing the hair cells that transduce sound http://purl.obolibrary.org/obo/MP_0000032 cochlear degeneration http://purl.obolibrary.org/obo/MP_0000031 abnormal cochlea morphology a retrogressive impairment of function or destruction of the spiral-shaped bony canal in the inner ear containing the hair cells that transduce sound http://purl.obolibrary.org/obo/MP_0000033 absent scala media http://purl.obolibrary.org/obo/MP_0003169 abnormal scala media morphology missing spiral tube within the cochlea that contains the organ of Corti, the neuroepithelial receptor organ for hearing http://purl.obolibrary.org/obo/MP_0000034 abnormal inner ear vestibule morphology http://purl.obolibrary.org/obo/MP_0000026 abnormal inner ear morphology any structural anomaly of the cavity between the semicircular canals and the cochlea of the inner ear http://purl.obolibrary.org/obo/MP_0000035 abnormal membranous labyrinth morphology http://purl.obolibrary.org/obo/MP_0000026 abnormal inner ear morphology any structural anomaly of the complex arrangement of communicating canaliculi and sacs suspended within the cavity of the bony labyrinth of the inner ear http://purl.obolibrary.org/obo/MP_0000036 absent semicircular canals http://purl.obolibrary.org/obo/MP_0002428 abnormal semicircular canal morphology missing organ of balance; consists of three bony tubes within which the semicircular ducts are located http://purl.obolibrary.org/obo/MP_0000037 abnormal lateral semicircular canal morphology http://purl.obolibrary.org/obo/MP_0002428 abnormal semicircular canal morphology any structural anomaly of the lateral long bony tube of the labyrinth that is involved in the sense of balance http://purl.obolibrary.org/obo/MP_0000039 abnormal otic capsule morphology http://purl.obolibrary.org/obo/MP_0000026 abnormal inner ear morphology any structural anomaly of the cartilage or bony capsule surrounding the inner ear mechanism http://purl.obolibrary.org/obo/MP_0000040 absent middle ear ossicles http://purl.obolibrary.org/obo/MP_0005105 abnormal middle ear ossicle morphology missing small bones of the tympanic cavity http://purl.obolibrary.org/obo/MP_0000041 absent endolymphatic duct http://purl.obolibrary.org/obo/MP_0006011 abnormal endolymphatic duct morphology missing small membranous canal of the inner ear; connecting membranous labyrinth with the endolymphatic sac http://purl.obolibrary.org/obo/MP_0000042 abnormal organ of Corti morphology http://purl.obolibrary.org/obo/MP_0003169 abnormal scala media morphology any structural anomaly associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla http://purl.obolibrary.org/obo/MP_0000043 organ of Corti degeneration http://purl.obolibrary.org/obo/MP_0000042 abnormal organ of Corti morphology a retrogressive impairment of function or destruction of all or part the highly specialized epithelium in the floor of the ductus cochlearis http://purl.obolibrary.org/obo/MP_0000044 absent organ of Corti http://purl.obolibrary.org/obo/MP_0000042 abnormal organ of Corti morphology absence of the highly specialized epithelium in the floor of the ductus cochlearis http://purl.obolibrary.org/obo/MP_0000045 abnormal hair cell morphology http://purl.obolibrary.org/obo/MP_0000972 abnormal mechanoreceptor morphology any structural anomaly of the sensory epithelial cells of the inner ear http://purl.obolibrary.org/obo/MP_0000046 abnormal sulcus ampullaris morphology http://purl.obolibrary.org/obo/MP_0000026 abnormal inner ear morphology any structural anomaly of the transverse groove on the membranous amupulla of each semicircular duct, where the nerve enters the ampullary crest http://purl.obolibrary.org/obo/MP_0000048 abnormal stria vascularis morphology http://purl.obolibrary.org/obo/MP_0003169 abnormal scala media morphology any structural anomaly in the stratified, secretory epithelium which lines the upper part of the cochlear spiral ligament and maintains potassium ion homeostasis in the endolymph; stria vascularis normally consists of marginal, intermediate, and basal cells: basal and marginal cell tight junctions preclude paracellular diffusion into and out of the intrastrial space while basal and intermediate cells secrete into this space potassium ions derived from fibrocytes through gap junctions http://purl.obolibrary.org/obo/MP_0000049 abnormal middle ear morphology http://purl.obolibrary.org/obo/MP_0002102 abnormal ear morphology any structural anomaly of any components of the tympanic cavity or its ossicles http://purl.obolibrary.org/obo/MP_0000052 early ear unfolding http://purl.obolibrary.org/obo/MP_0002177 abnormal outer ear morphology early onset of the opening and spreading out of the outer ear http://purl.obolibrary.org/obo/MP_0000053 excessive ear growth http://purl.obolibrary.org/obo/MP_0002177 abnormal outer ear morphology overly robust development of the ear http://purl.obolibrary.org/obo/MP_0000054 delayed ear emergence http://purl.obolibrary.org/obo/MP_0002177 abnormal outer ear morphology late onset of the growth of the outer ear http://purl.obolibrary.org/obo/MP_0000060 delayed bone ossification http://purl.obolibrary.org/obo/MP_0008271 abnormal bone ossification late onset of the formation of bone http://purl.obolibrary.org/obo/MP_0000061 fragile skeleton http://purl.obolibrary.org/obo/MP_0001542 abnormal bone strength easily damaged or broken bones http://purl.obolibrary.org/obo/MP_0000062 increased bone mineral density http://purl.obolibrary.org/obo/MP_0010119 abnormal bone mineral density elevation in the amount of mineral per square centimeter of bone (usually g/cm2), used as a measure of structural strength and screen for osteoporosis; bone mineral density is the ratio of bone mineral content to bone size http://purl.obolibrary.org/obo/MP_0000063 decreased bone mineral density http://purl.obolibrary.org/obo/MP_0010119 abnormal bone mineral density reduction in the amount of mineral per square centimeter of bone (usually g/cm2), used as a measure of structural strength and screen for osteoporosis; bone mineral density is the ratio of bone mineral content to bone size http://purl.obolibrary.org/obo/MP_0000064 failure of secondary bone resorption http://purl.obolibrary.org/obo/MP_0004945 abnormal bone resorption inability to degrade the organic and inorganic phases of bone by absorption, usually by the abnormal function or by absence of osteoclasts http://purl.obolibrary.org/obo/MP_0000065 abnormal bone marrow cavity morphology http://purl.obolibrary.org/obo/MP_0003795 abnormal bone structure any structural anomaly of the medullary cavities of the bones http://purl.obolibrary.org/obo/MP_0000066 osteoporosis http://purl.obolibrary.org/obo/MP_0004016 decreased bone mass reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility http://purl.obolibrary.org/obo/MP_0000067 osteopetrosis http://purl.obolibrary.org/obo/MP_0005605 increased bone mass excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis http://purl.obolibrary.org/obo/MP_0000069 kyphoscoliosis http://purl.obolibrary.org/obo/MP_0004174 abnormal spine curvature kyphosis combined with scoliosis http://purl.obolibrary.org/obo/MP_0000071 axial skeleton hypoplasia http://purl.obolibrary.org/obo/MP_0002114 abnormal axial skeleton morphology underdevelopment or reduced size in the skeletal elements of the trunk, usually due to reduced cell number http://purl.obolibrary.org/obo/MP_0000073 absent craniofacial bones http://purl.obolibrary.org/obo/MP_0002116 abnormal craniofacial bone morphology missing skeletal elements comprising the cranium and face http://purl.obolibrary.org/obo/MP_0000074 abnormal neurocranium morphology http://purl.obolibrary.org/obo/MP_0000438 abnormal cranium morphology any structural anomaly of the bones of the skull enclosing the brain http://purl.obolibrary.org/obo/MP_0000075 absent neurocranium http://purl.obolibrary.org/obo/MP_0000074 abnormal neurocranium morphology missing bones of the skull enclosing the brain http://purl.obolibrary.org/obo/MP_0000077 abnormal interparietal bone morphology http://purl.obolibrary.org/obo/MP_0000074 abnormal neurocranium morphology any structural anomaly of the bone of the cranium that lies above and anterior to the occipital bone in some mammals http://purl.obolibrary.org/obo/MP_0000078 abnormal supraoccipital bone morphology http://purl.obolibrary.org/obo/MP_0005269 abnormal occipital bone morphology any structural anomaly of the bone on the dorsal side of the great foramen of the skull, usually forming a part of the occipital in the adult, but distinct in the young http://purl.obolibrary.org/obo/MP_0000079 abnormal basioccipital bone morphology http://purl.obolibrary.org/obo/MP_0010029 abnormal basicranium morphology any structural anomaly of the basilar process of the occipital bone in the base of the cranium, frequently forming a direct part of the occipital in the adult, but usually distinct in the young http://purl.obolibrary.org/obo/MP_0000080 abnormal exoccipital bone morphology http://purl.obolibrary.org/obo/MP_0005269 abnormal occipital bone morphology any structural anomaly of the bone or region on the lateral sides of the great foremen of the skull, which often forms a part of the occipital in the adult, but is usually distinct in the young http://purl.obolibrary.org/obo/MP_0000081 premature suture closure http://purl.obolibrary.org/obo/MP_0003418 premature intramembranous bone ossification early fusion of the bones of the skull http://purl.obolibrary.org/obo/MP_0000082 overlapping parietal bones http://purl.obolibrary.org/obo/MP_0000074 abnormal neurocranium morphology parietal bones of the skull partly coincide instead of articulating http://purl.obolibrary.org/obo/MP_0000083 ectopic cranial bone growth http://purl.obolibrary.org/obo/MP_0009585 ectopic bone formation growth of extra bony structures in or near the cranium http://purl.obolibrary.org/obo/MP_0000084 abnormal fontanelle morphology http://purl.obolibrary.org/obo/MP_0002113 abnormal skeleton development any structural anomaly in the membranous interval at the margins of cranial bones in neonates http://purl.obolibrary.org/obo/MP_0000085 large anterior fontanelle http://purl.obolibrary.org/obo/MP_0000084 abnormal fontanelle morphology enlarged diamond-shaped membranous interval at the junction of the coronal, sagittal and metopic sutures of the cranium http://purl.obolibrary.org/obo/MP_0000087 absent mandible http://purl.obolibrary.org/obo/MP_0000458 abnormal mandible morphology missing the lower bony framework of the mouth where the inferior teeth are held http://purl.obolibrary.org/obo/MP_0000088 short mandible http://purl.obolibrary.org/obo/MP_0004592 small mandible reduced length of the lower bony framework of the mouth where the inferior teeth are held http://purl.obolibrary.org/obo/MP_0000090 absent premaxilla http://purl.obolibrary.org/obo/MP_0002820 abnormal premaxilla morphology missing anterior and interior portion of the maxilla http://purl.obolibrary.org/obo/MP_0000091 short premaxilla http://purl.obolibrary.org/obo/MP_0004870 small premaxilla reduced length of the anterior and interior portion of the maxilla http://purl.obolibrary.org/obo/MP_0000094 absent alveolar process http://purl.obolibrary.org/obo/MP_0004189 abnormal alveolar process morphology missing projecting ridge on the inferior surface of the body of the maxilla and mandible containing the tooth sockets http://purl.obolibrary.org/obo/MP_0000097 short maxilla http://purl.obolibrary.org/obo/MP_0004540 small maxilla reduced length of the upper jaw bone http://purl.obolibrary.org/obo/MP_0000098 abnormal vomer bone morphology http://purl.obolibrary.org/obo/MP_0005274 abnormal viscerocranium morphology any structural anomaly of the triangular flat bone of the nasal septum http://purl.obolibrary.org/obo/MP_0000099 absent vomer bone http://purl.obolibrary.org/obo/MP_0000098 abnormal vomer bone morphology missing triangular flat bone of the nasal septum http://purl.obolibrary.org/obo/MP_0000100 abnormal ethmoidal bone morphology http://purl.obolibrary.org/obo/MP_0005274 abnormal viscerocranium morphology any structural anomaly of the midline facial bone that encloses the nasal cavity http://purl.obolibrary.org/obo/MP_0000101 absent ethmoidal bone http://purl.obolibrary.org/obo/MP_0000100 abnormal ethmoidal bone morphology missing midline facial bone that encloses the nasal cavity http://purl.obolibrary.org/obo/MP_0000102 abnormal nasal bone morphology http://purl.obolibrary.org/obo/MP_0005274 abnormal viscerocranium morphology any structural anomaly of either of two rectangular bone plates forming the bridge of the nose http://purl.obolibrary.org/obo/MP_0000103 nasal bone hypoplasia http://purl.obolibrary.org/obo/MP_0004470 small nasal bone underdevelopment or reduced size, usually due to a reduced number of cells, in the bone which forms the nasal bridge http://purl.obolibrary.org/obo/MP_0000104 abnormal sphenoid bone morphology http://purl.obolibrary.org/obo/MP_0000074 abnormal neurocranium morphology any structural anomaly of the irregularly shaped bone of the base of the skull http://purl.obolibrary.org/obo/MP_0000105 impaired ossification of basisphenoid bone http://purl.obolibrary.org/obo/MP_0008273 abnormal intramembranous bone ossification anomaly in the formation of the bone at the base of the sphenoid bone; arises from an ossification center independent of the remainder of the sphenoid bone http://purl.obolibrary.org/obo/MP_0000106 abnormal basisphenoid bone morphology http://purl.obolibrary.org/obo/MP_0010029 abnormal basicranium morphology any structural anomaly of part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone http://purl.obolibrary.org/obo/MP_0000107 abnormal frontal bone morphology http://purl.obolibrary.org/obo/MP_0005274 abnormal viscerocranium morphology any structural anomaly of the bone forming the forehead and roof of the eye orbit http://purl.obolibrary.org/obo/MP_0000108 midline facial cleft http://purl.obolibrary.org/obo/MP_0008797 facial cleft incomplete merging or fusion of the tissues (e.g. the two globular processes) along the facial midline that normally unite to form the face http://purl.obolibrary.org/obo/MP_0000109 abnormal parietal bone morphology http://purl.obolibrary.org/obo/MP_0000074 abnormal neurocranium morphology any structural anomaly of the curved bone forming part of the vault of the cranium http://purl.obolibrary.org/obo/MP_0000111 cleft palate http://purl.obolibrary.org/obo/MP_0003755 abnormal palate morphology congenital fissure of the tissues normally uniting to form the palate http://purl.obolibrary.org/obo/MP_0000114 cleft chin http://purl.obolibrary.org/obo/MP_0000458 abnormal mandible morphology incomplete fusion of the chin; usually a fissure http://purl.obolibrary.org/obo/MP_0000116 abnormal tooth development http://purl.obolibrary.org/obo/MP_0003935 abnormal craniofacial development any anomaly in the formation of the teeth http://purl.obolibrary.org/obo/MP_0000117 absent tooth primordium http://purl.obolibrary.org/obo/MP_0000116 abnormal tooth development missing the cells that will give rise to teeth http://purl.obolibrary.org/obo/MP_0000118 arrest of tooth development http://purl.obolibrary.org/obo/MP_0000116 abnormal tooth development failure of differentiation of the teeth http://purl.obolibrary.org/obo/MP_0000119 abnormal tooth eruption http://purl.obolibrary.org/obo/MP_0002100 abnormal tooth morphology anomalies in the passage of a tooth through the alveolar process and perforation of the gums http://purl.obolibrary.org/obo/MP_0000120 malocclusion http://purl.obolibrary.org/obo/MP_0000438 abnormal cranium morphology perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth http://purl.obolibrary.org/obo/MP_0000121 failure of tooth eruption http://purl.obolibrary.org/obo/MP_0000119 abnormal tooth eruption inability of the teeth to grow into the oral cavity http://purl.obolibrary.org/obo/MP_0000122 accelerated tooth eruption http://purl.obolibrary.org/obo/MP_0000119 abnormal tooth eruption early onset of the growth of the teeth out of the gums http://purl.obolibrary.org/obo/MP_0000124 absent teeth http://purl.obolibrary.org/obo/MP_0002100 abnormal tooth morphology absence of some or all of the bony structures of the upper and lower jaws used in mastication http://purl.obolibrary.org/obo/MP_0000125 absent incisors http://purl.obolibrary.org/obo/MP_0005358 abnormal incisor morphology absence of the pairs of long teeth that are the most anterior and prominent in the jaw http://purl.obolibrary.org/obo/MP_0000126 brittle teeth http://purl.obolibrary.org/obo/MP_0002100 abnormal tooth morphology fragile and likely to break teeth http://purl.obolibrary.org/obo/MP_0000127 degenerate molars http://purl.obolibrary.org/obo/MP_0002689 abnormal molar morphology deterioration or loss over time of the molars http://purl.obolibrary.org/obo/MP_0000128 growth retardation of molars http://purl.obolibrary.org/obo/MP_0000116 abnormal tooth development developmental delay of the growth of the molars http://purl.obolibrary.org/obo/MP_0000129 ameloblast degeneration http://purl.obolibrary.org/obo/MP_0002650 abnormal ameloblast morphology a retrogressive impairment of function or destruction of the epithelial cells of the inner later of the enamel organ of the developing tooth http://purl.obolibrary.org/obo/MP_0000130 abnormal trabecular bone morphology http://purl.obolibrary.org/obo/MP_0003795 abnormal bone structure any structural anomaly of bone that has a lattice-like or spongy structure; it is highly vascular and contains intercommunicating spaces filled with bone marrow http://purl.obolibrary.org/obo/MP_0000131 abnormal long bone epiphysis morphology http://purl.obolibrary.org/obo/MP_0003723 abnormal long bone morphology any structural anomaly of the rounded end of a long bone http://purl.obolibrary.org/obo/MP_0000132 thickened long bone epiphysis http://purl.obolibrary.org/obo/MP_0000131 abnormal long bone epiphysis morphology wider than normal rounded end of a long bone http://purl.obolibrary.org/obo/MP_0000133 abnormal long bone metaphysis morphology http://purl.obolibrary.org/obo/MP_0003723 abnormal long bone morphology any structural anomaly of the conical section of bone between the epiphysis and diaphysis of the long bones; this section grows during childhood and juvenile stages and is completely ossified in adults http://purl.obolibrary.org/obo/MP_0000134 abnormal compact bone thickness http://purl.obolibrary.org/obo/MP_0003797 abnormal compact bone morphology reduced or increased width of the superficial layer of compact bone http://purl.obolibrary.org/obo/MP_0000135 decreased compact bone thickness http://purl.obolibrary.org/obo/MP_0000134 abnormal compact bone thickness thinner than normal superficial layer of compact bone http://purl.obolibrary.org/obo/MP_0000136 abnormal microglial cell morphology http://purl.obolibrary.org/obo/MP_0002446 abnormal macrophage morphology any structural anomaly of the small, migratory, phagocytic, interstitial cells derived from myeloid progenitor cells and found in the parenchyma of the central nervous system; microglia are scavengers, engulfing dead cells and other debris, and in Alzheimer's disease, microglia are found associated with dying nerve cells and amyloid plaques http://purl.obolibrary.org/obo/MP_0000137 abnormal vertebrae morphology http://purl.obolibrary.org/obo/MP_0004703 abnormal vertebral column morphology any structural anomaly of the bony segments of the spinal column http://purl.obolibrary.org/obo/MP_0000138 absent vertebrae http://purl.obolibrary.org/obo/MP_0000137 abnormal vertebrae morphology missing all of the bony segments of the spinal column http://purl.obolibrary.org/obo/MP_0000139 absent vertebral transverse processes http://purl.obolibrary.org/obo/MP_0004600 abnormal vertebral transverse process morphology loss of the bony protrusions on either side of the arch of a vertebrae at the point where the lamina joins the pedicle, between the superior and inferior articular processes; muscles and ligaments attach to these processes http://purl.obolibrary.org/obo/MP_0000140 absent vertebral pedicles http://purl.obolibrary.org/obo/MP_0004604 abnormal vertebral pedicle morphology loss of the two short, thick processes, which project backward, one on either side, from the upper part of the body to the laminae http://purl.obolibrary.org/obo/MP_0000141 abnormal vertebral body morphology http://purl.obolibrary.org/obo/MP_0000137 abnormal vertebrae morphology any structural anomaly of the main cylindrical portion of the vertebra ventral to the vertebral canal http://purl.obolibrary.org/obo/MP_0000149 abnormal scapula morphology http://purl.obolibrary.org/obo/MP_0004508 abnormal pectoral girdle bone morphology any structural anomaly of either or both of the large, flat bones of the back part of the shoulder http://purl.obolibrary.org/obo/MP_0000150 abnormal rib morphology http://purl.obolibrary.org/obo/MP_0004624 abnormal thoracic cage morphology any structural anomaly of the bones forming the bony wall of the chest http://purl.obolibrary.org/obo/MP_0000151 absent ribs http://purl.obolibrary.org/obo/MP_0003345 decreased rib number absence of all the pairs of bony structures that make up the body wall http://purl.obolibrary.org/obo/MP_0000152 absent proximal rib http://purl.obolibrary.org/obo/MP_0000151 absent ribs missing part of rib structures near the spine, ribs do not contact vertebrae http://purl.obolibrary.org/obo/MP_0000153 rib bifurcation http://purl.obolibrary.org/obo/MP_0000150 abnormal rib morphology forking or division of ribs, may be a result of partial rib fusions http://purl.obolibrary.org/obo/MP_0000154 rib fusion http://purl.obolibrary.org/obo/MP_0000150 abnormal rib morphology appearance of one or more ribs as a single structure http://purl.obolibrary.org/obo/MP_0000155 asymmetric rib attachment http://purl.obolibrary.org/obo/MP_0004625 abnormal rib attachment loss of bilateral symmetry in rib attachments to the vertebral column or to the sternum http://purl.obolibrary.org/obo/MP_0000157 abnormal sternum morphology http://purl.obolibrary.org/obo/MP_0004624 abnormal thoracic cage morphology any structural anomaly of the long flat bone of the chest that articulates with clavicle and first seven rib pairs; from rostral to caudal positions, the sternum consists of three parts: manubrium, body, and xiphoid process http://purl.obolibrary.org/obo/MP_0000158 absent sternum http://purl.obolibrary.org/obo/MP_0000157 abnormal sternum morphology missing long flat bone of the chest; articulates with clavicle and first seven rib pairs http://purl.obolibrary.org/obo/MP_0000159 abnormal xiphoid process morphology http://purl.obolibrary.org/obo/MP_0000157 abnormal sternum morphology any structural anomaly of the caudal tip of the sternum http://purl.obolibrary.org/obo/MP_0000160 kyphosis http://purl.obolibrary.org/obo/MP_0004174 abnormal spine curvature forward curvature of the spine, characterized by extensive flexion http://purl.obolibrary.org/obo/MP_0000161 scoliosis http://purl.obolibrary.org/obo/MP_0004174 abnormal spine curvature lateral and rotational curvature of the spine http://purl.obolibrary.org/obo/MP_0000162 lordosis http://purl.obolibrary.org/obo/MP_0004174 abnormal spine curvature anteriorly convex curvature of the spine http://purl.obolibrary.org/obo/MP_0000163 abnormal cartilage morphology http://purl.obolibrary.org/obo/MP_0005508 abnormal skeleton morphology any structural anomaly of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the thorax, and tubular structures, but which also comprises most of the skeleton in early fetal life http://purl.obolibrary.org/obo/MP_0000164 abnormal cartilage development http://purl.obolibrary.org/obo/MP_0002113 abnormal skeleton development anomaly in the formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the thorax, and tubular structures, but which also comprises most of the skeleton in early fetal life http://purl.obolibrary.org/obo/MP_0000165 abnormal long bone hypertrophic chondrocyte zone http://purl.obolibrary.org/obo/MP_0003055 abnormal long bone epiphyseal plate morphology anomaly of the layer of the epiphyseal plate of a long bone where chondrocytes mature and enlarge http://purl.obolibrary.org/obo/MP_0000166 abnormal chondrocyte morphology http://purl.obolibrary.org/obo/MP_0000163 abnormal cartilage morphology any structural anomaly of a polymorphic cell that forms cartilage http://purl.obolibrary.org/obo/MP_0000167 decreased chondrocyte number http://purl.obolibrary.org/obo/MP_0000166 abnormal chondrocyte morphology fewer than normal numbers of polymorphic cells that form cartilage http://purl.obolibrary.org/obo/MP_0000168 abnormal bone marrow development http://purl.obolibrary.org/obo/MP_0002113 abnormal skeleton development anomaly in the formation of the soft, pulpy tissue filling the medullary cavities of bones http://purl.obolibrary.org/obo/MP_0000172 abnormal bone marrow cell number http://purl.obolibrary.org/obo/MP_0002398 abnormal bone marrow cell morphology/development increased or decreased number of cells that make up the core cavities of bones when compared to controls http://purl.obolibrary.org/obo/MP_0000175 absent bone marrow cell http://purl.obolibrary.org/obo/MP_0000333 decreased bone marrow cell number lack of cells that make up the core cavities of bones http://purl.obolibrary.org/obo/MP_0000180 abnormal circulating cholesterol level http://purl.obolibrary.org/obo/MP_0003949 abnormal circulating lipid level anomaly in the amount in the blood of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues http://purl.obolibrary.org/obo/MP_0000181 abnormal circulating LDL cholesterol level http://purl.obolibrary.org/obo/MP_0020151 abnormal circulating non-HDL cholesterol level any anomaly in the amount in the blood of the lipoprotein:cholesterol complex that transports cholesterol out of the arteries and around the body, for use by various tissues in normal bodily functions http://purl.obolibrary.org/obo/MP_0000182 increased circulating LDL cholesterol level http://purl.obolibrary.org/obo/MP_0005178 increased circulating cholesterol level greater amount in the blood of the lipoprotein:cholesterol complex that transports cholesterol out of the arteries and around the body, for use by various tissues in normal bodily functions http://purl.obolibrary.org/obo/MP_0000183 decreased circulating LDL cholesterol level http://purl.obolibrary.org/obo/MP_0005179 decreased circulating cholesterol level reduced amount in the blood of the lipoprotein:cholesterol complex that transports cholesterol out of the arteries and around the body, for use by various tissues in normal bodily functions http://purl.obolibrary.org/obo/MP_0000184 abnormal circulating HDL cholesterol level http://purl.obolibrary.org/obo/MP_0010330 abnormal circulating lipoprotein level any anomaly in the amount in the blood of the small lipoprotein:cholesterol complex that transports cholesterol out of the arteries and to the liver for reprocessing or excretion http://purl.obolibrary.org/obo/MP_0000186 decreased circulating HDL cholesterol level http://purl.obolibrary.org/obo/MP_0005179 decreased circulating cholesterol level reduced amount in the blood of the small lipoprotein:cholesterol complex that transports cholesterol out of the arteries and to the liver for reprocessing or excretion http://purl.obolibrary.org/obo/MP_0000187 abnormal triglyceride level http://purl.obolibrary.org/obo/MP_0001547 abnormal lipid level any anomaly in the concentration of triglyceride, a glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue http://purl.obolibrary.org/obo/MP_0000188 abnormal circulating glucose level http://purl.obolibrary.org/obo/MP_0009642 abnormal blood homeostasis any anomaly in the concentration in the blood of the major monosaccharide of the body http://purl.obolibrary.org/obo/MP_0000189 hypoglycemia http://purl.obolibrary.org/obo/MP_0005560 decreased circulating glucose level low levels of plasma glucose in the circulating blood; this generally refers to a pathological state http://purl.obolibrary.org/obo/MP_0000192 abnormal mineral level http://purl.obolibrary.org/obo/MP_0005636 abnormal mineral homeostasis any anomaly in the concentration of any inorganic substance that has importance in body functions http://purl.obolibrary.org/obo/MP_0000194 increased circulating calcium level http://purl.obolibrary.org/obo/MP_0001562 abnormal circulating calcium level abnormally high concentration of calcium ions in the circulating blood http://purl.obolibrary.org/obo/MP_0000195 decreased circulating calcium level http://purl.obolibrary.org/obo/MP_0001562 abnormal circulating calcium level subnormal concentrations of calcium ions in the circulating blood http://purl.obolibrary.org/obo/MP_0000198 decreased circulating phosphate level http://purl.obolibrary.org/obo/MP_0001565 abnormal circulating phosphate level abnormally low concentrations of phosphates in the circulating blood http://purl.obolibrary.org/obo/MP_0000199 abnormal circulating serum albumin level http://purl.obolibrary.org/obo/MP_0005416 abnormal circulating protein level anomaly in the blood level of the major blood protein that is important in maintaining the colloidal osmotic pressure, fatty acid transport and transporting large organic molecules http://purl.obolibrary.org/obo/MP_0000202 abnormal circulating alkaline phosphatase level http://purl.obolibrary.org/obo/MP_0001570 abnormal circulating enzyme level any anomaly in the concentration in the blood of the enzyme which hydrolyzes orthophosphoric monoesters; low levels are seen in cases of hypophosphatasia http://purl.obolibrary.org/obo/MP_0000203 abnormal circulating aspartate transaminase level http://purl.obolibrary.org/obo/MP_0001570 abnormal circulating enzyme level any anomaly in the concentration in the blood of the enzyme which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid http://purl.obolibrary.org/obo/MP_0000208 decreased hematocrit http://purl.obolibrary.org/obo/MP_0002596 abnormal hematocrit less than the average percentage of a volume of a blood sample occupied by red blood cells http://purl.obolibrary.org/obo/MP_0000215 absent erythrocytes http://purl.obolibrary.org/obo/MP_0002875 decreased erythrocyte cell number lack of mature red blood cells http://purl.obolibrary.org/obo/MP_0000216 absent erythroid progenitor cell http://purl.obolibrary.org/obo/MP_0008973 decreased erythroid progenitor cell number lack of progenitors of the erythrocyte lineage http://purl.obolibrary.org/obo/MP_0000217 abnormal leukocyte cell number http://purl.obolibrary.org/obo/MP_0011180 abnormal hematopoietic cell number any anomaly in the number of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue http://purl.obolibrary.org/obo/MP_0000218 increased leukocyte cell number http://purl.obolibrary.org/obo/MP_0011181 increased hematopoietic cell number greater than normal number of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue http://purl.obolibrary.org/obo/MP_0000219 increased neutrophil cell number http://purl.obolibrary.org/obo/MP_0012440 abnormal neutrophil cell number greater than normal number of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes http://purl.obolibrary.org/obo/MP_0000220 increased monocyte cell number http://purl.obolibrary.org/obo/MP_0012441 abnormal monocyte cell number greater count of the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood http://purl.obolibrary.org/obo/MP_0000221 decreased leukocyte cell number http://purl.obolibrary.org/obo/MP_0011182 decreased hematopoietic cell number reduction in the number of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue http://purl.obolibrary.org/obo/MP_0000222 decreased neutrophil cell number http://purl.obolibrary.org/obo/MP_0012440 abnormal neutrophil cell number reduced count of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes http://purl.obolibrary.org/obo/MP_0000223 decreased monocyte cell number http://purl.obolibrary.org/obo/MP_0012441 abnormal monocyte cell number reduced count of the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood http://purl.obolibrary.org/obo/MP_0000226 abnormal mean corpuscular volume http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology deviation from normal for the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices http://purl.obolibrary.org/obo/MP_0000228 abnormal thrombopoiesis http://purl.obolibrary.org/obo/MP_0002417 abnormal megakaryocyte morphology abnormal development of the non-nucleated cells of the blood (platelets, thrombocytes) involved in blood coagulation http://purl.obolibrary.org/obo/MP_0000229 abnormal megakaryocyte differentiation http://purl.obolibrary.org/obo/MP_0005076 abnormal cell differentiation atypical production of or inability to produce of a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm http://purl.obolibrary.org/obo/MP_0000230 abnormal systemic arterial blood pressure http://purl.obolibrary.org/obo/MP_0001544 abnormal cardiovascular system physiology altered tension of the blood within the systemic arteries http://purl.obolibrary.org/obo/MP_0000231 hypertension http://purl.obolibrary.org/obo/MP_0002842 increased systemic arterial blood pressure sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states http://purl.obolibrary.org/obo/MP_0000233 abnormal blood flow velocity http://purl.obolibrary.org/obo/MP_0002128 abnormal blood circulation any anomaly in the rate of flow of the blood through vessels http://purl.obolibrary.org/obo/MP_0000238 absent pre-B cells http://purl.obolibrary.org/obo/MP_0008213 absent immature B cells absence of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface http://purl.obolibrary.org/obo/MP_0000239 absent common myeloid progenitor cells http://purl.obolibrary.org/obo/MP_0008813 decreased common myeloid progenitor cell number lack of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages http://purl.obolibrary.org/obo/MP_0000240 extramedullary hematopoiesis http://purl.obolibrary.org/obo/MP_0002123 abnormal hematopoiesis formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes http://purl.obolibrary.org/obo/MP_0000242 impaired fertilization http://purl.obolibrary.org/obo/MP_0005410 abnormal fertilization defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronuclei http://purl.obolibrary.org/obo/MP_0000243 myoclonus http://purl.obolibrary.org/obo/MP_0000947 convulsive seizures involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion http://purl.obolibrary.org/obo/MP_0000245 abnormal erythropoiesis http://purl.obolibrary.org/obo/MP_0002123 abnormal hematopoiesis atypical process of the formation of enucleated fetal and adult erythrocytes http://purl.obolibrary.org/obo/MP_0000248 macrocytosis http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology condition in which erythrocytes are larger than normal in size http://purl.obolibrary.org/obo/MP_0000249 abnormal blood vessel physiology http://purl.obolibrary.org/obo/MP_0001544 abnormal cardiovascular system physiology any functional anomaly of any of the tubes that convey blood including the arteries, arterioles, capillaries, venules, and veins http://purl.obolibrary.org/obo/MP_0000250 abnormal vasoconstriction http://purl.obolibrary.org/obo/MP_0005620 abnormal muscle contractility anomaly in the narrowing of the blood vessels by smooth muscle contraction http://purl.obolibrary.org/obo/MP_0000255 vasculature congestion http://purl.obolibrary.org/obo/MP_0001614 abnormal blood vessel morphology obstruction of the normal flux of blood within the blood vessel network http://purl.obolibrary.org/obo/MP_0000256 echinocytosis http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology a state in which the red blood cells have multiple small projections appearing over the cell circumference resembling a small burr or a sea urchin http://purl.obolibrary.org/obo/MP_0000259 abnormal vascular development http://purl.obolibrary.org/obo/MP_0002925 abnormal cardiovascular development aberrant process of vascular formation http://purl.obolibrary.org/obo/MP_0000260 abnormal angiogenesis http://purl.obolibrary.org/obo/MP_0000259 abnormal vascular development aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network http://purl.obolibrary.org/obo/MP_0000262 poor arterial differentiation http://purl.obolibrary.org/obo/MP_0003410 abnormal artery development failure of or inadequate acquisition of the characteristics and/or functions of the arteries http://purl.obolibrary.org/obo/MP_0000263 absent organized vascular network http://purl.obolibrary.org/obo/MP_0001622 abnormal vasculogenesis formation of vasculature, but failure to differentiate into stereotypic organized pattern http://purl.obolibrary.org/obo/MP_0000264 failure of vascular branching http://purl.obolibrary.org/obo/MP_0003227 abnormal vascular branching morphogenesis failure of vasculature to form divisions (offshoots) http://purl.obolibrary.org/obo/MP_0000265 atretic vasculature http://purl.obolibrary.org/obo/MP_0001614 abnormal blood vessel morphology absence or absence of the lumen of vasculature http://purl.obolibrary.org/obo/MP_0000266 abnormal heart morphology http://purl.obolibrary.org/obo/MP_0002127 abnormal cardiovascular system morphology any structural anomaly of the hollow, muscular organ that maintains the circulation of the blood http://purl.obolibrary.org/obo/MP_0000267 abnormal heart development http://purl.obolibrary.org/obo/MP_0002925 abnormal cardiovascular development aberrant formation or incomplete differentiation of the heart http://purl.obolibrary.org/obo/MP_0000269 abnormal heart looping http://purl.obolibrary.org/obo/MP_0000267 abnormal heart development any anomaly in the characteristic morphogenetic movements where the primitive heart tube loops asymmetrically during early development; this looping brings the primitive heart chambers into alignment preceding their future integration http://purl.obolibrary.org/obo/MP_0000270 abnormal heart tube morphology http://purl.obolibrary.org/obo/MP_0000267 abnormal heart development any structural anomaly of the primitive epithelial cardiac tube before the division into the chambers of the mature heart http://purl.obolibrary.org/obo/MP_0000272 abnormal aorta morphology http://purl.obolibrary.org/obo/MP_0011655 abnormal systemic artery morphology any structural anomaly of the main trunk of the systemic arterial system that originates from the base of the left ventricle of the heart and extends to the abdomen at the point where it branches into the common iliac arteries http://purl.obolibrary.org/obo/MP_0000273 overriding aortic valve http://purl.obolibrary.org/obo/MP_0010426 abnormal heart and great artery attachment congenitally abnormal position of the aorta where the valve origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left, frequently in conjunction with a ventricular septal defect http://purl.obolibrary.org/obo/MP_0000274 enlarged heart http://purl.obolibrary.org/obo/MP_0005406 abnormal heart size increase over normal size of the heart http://purl.obolibrary.org/obo/MP_0000275 heart hyperplasia http://purl.obolibrary.org/obo/MP_0000274 enlarged heart overdevelopment or increased size of the heart, usually due an increased number of cells http://purl.obolibrary.org/obo/MP_0000276 heart right ventricle hypertrophy http://purl.obolibrary.org/obo/MP_0010563 increased heart right ventricle size increased size of the right ventricle http://purl.obolibrary.org/obo/MP_0000277 abnormal heart shape http://purl.obolibrary.org/obo/MP_0000266 abnormal heart morphology any anomaly in the characteristic surface outline or contour of the heart http://purl.obolibrary.org/obo/MP_0000278 abnormal myocardial fiber morphology http://purl.obolibrary.org/obo/MP_0010630 abnormal cardiac muscle tissue morphology any structural anomaly of the terminally differentiated, non-proliferative, cardiac muscle fibers, the multinucleated muscle cells of the heart http://purl.obolibrary.org/obo/MP_0000279 ventricular hypoplasia http://purl.obolibrary.org/obo/MP_0005294 abnormal heart ventricle morphology underdevelopment or reduced size, usually due to a reduced number of cells, of one or both of the two lower chambers of the heart http://purl.obolibrary.org/obo/MP_0000280 thin ventricular wall http://purl.obolibrary.org/obo/MP_0020135 abnormal heart ventricle wall thickness decreased depth of the cardiac wall of the heart ventricles http://purl.obolibrary.org/obo/MP_0000281 abnormal interventricular septum morphology http://purl.obolibrary.org/obo/MP_0006113 abnormal heart septum morphology any structural anomaly of the wall between the two lower chambers of the heart; the ventricular septum consists of a very small membranous portion just beneath the aortic valve, and a large thick muscular portion consisting of three sections including the inlet septum, the trabecular septum, and the outlet septum http://purl.obolibrary.org/obo/MP_0000282 abnormal interatrial septum morphology http://purl.obolibrary.org/obo/MP_0006113 abnormal heart septum morphology any structural anomaly of the thin membranous structure between the two heart atria http://purl.obolibrary.org/obo/MP_0000284 double outlet right ventricle http://purl.obolibrary.org/obo/MP_0010426 abnormal heart and great artery attachment both the aorta and the pulmonary trunk originate, either in whole or in part, from the right ventricle; often found in conjunction with a ventricular septal defect http://purl.obolibrary.org/obo/MP_0000285 abnormal heart valve morphology http://purl.obolibrary.org/obo/MP_0000266 abnormal heart morphology any structural anomaly of the membranous folds of the heart that prevent reflux of fluid http://purl.obolibrary.org/obo/MP_0000286 abnormal mitral valve morphology http://purl.obolibrary.org/obo/MP_0002745 abnormal atrioventricular valve morphology any structural anomaly of the valve between the left atrium and the left ventricle of the heart, and contains two cusps, the anterior cusp and the posterior cusp, attached to the outer fibrous ring (annulus) http://purl.obolibrary.org/obo/MP_0000287 heart valve hypoplasia http://purl.obolibrary.org/obo/MP_0000285 abnormal heart valve morphology underdevelopment or reduced size of the heart valves, usually due to a reduced number of cells, http://purl.obolibrary.org/obo/MP_0000288 abnormal pericardium morphology http://purl.obolibrary.org/obo/MP_0000266 abnormal heart morphology any structural anomaly of the fibroserous membrane covering the heart and beginning of the great vessels http://purl.obolibrary.org/obo/MP_0000291 enlarged pericardium http://purl.obolibrary.org/obo/MP_0000288 abnormal pericardium morphology extended fibroserous membrane covering the heart and beginning of the great vessels http://purl.obolibrary.org/obo/MP_0000292 distended pericardium http://purl.obolibrary.org/obo/MP_0000288 abnormal pericardium morphology an expansion in the volume of the sac-like structure contained by the outer parietal layer of the pericardium http://purl.obolibrary.org/obo/MP_0000293 absent myocardial trabeculae http://purl.obolibrary.org/obo/MP_0002189 abnormal myocardial trabeculae morphology absence of the supporting bundles of muscular fibers lining the walls of the heart http://purl.obolibrary.org/obo/MP_0000295 trabecula carnea hypoplasia http://purl.obolibrary.org/obo/MP_0010503 myocardial trabeculae hypoplasia underdevelopment or reduced size of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0000296 absent trabeculae carneae http://purl.obolibrary.org/obo/MP_0004067 abnormal trabecula carnea morphology missing supporting bundles of muscular fibers lining the walls of the ventricles of the heart http://purl.obolibrary.org/obo/MP_0000297 abnormal atrioventricular cushion morphology http://purl.obolibrary.org/obo/MP_0006107 abnormal fetal atrioventricular canal morphology any structural anomaly of the mounds of embryonic connective tissue that bulge into the fetal atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices and the atrioventricular septum http://purl.obolibrary.org/obo/MP_0000298 absent atrioventricular cushions http://purl.obolibrary.org/obo/MP_0000297 abnormal atrioventricular cushion morphology absence of the mounds of embryonic connective tissue that bulge into the fetal atrioventricular canal http://purl.obolibrary.org/obo/MP_0000299 failure of atrioventricular cushion closure http://purl.obolibrary.org/obo/MP_0010599 abnormal fetal atrioventricular canal septation failure of the mounds of embryonic connective tissue that bulge into the fetal atrioventricular canal to fuse to form the valves between the right and left atrioventricular orifices http://purl.obolibrary.org/obo/MP_0000300 thin atrioventricular cushion http://purl.obolibrary.org/obo/MP_0000301 decreased atrioventricular cushion size reduced thickness of the mounds of embryonic connective tissue that bulge into the fetal atrioventricular canal http://purl.obolibrary.org/obo/MP_0000301 decreased atrioventricular cushion size http://purl.obolibrary.org/obo/MP_0000297 abnormal atrioventricular cushion morphology smaller than normal mounds of embryonic connective tissue that bulge into the fetal atrioventricular canal http://purl.obolibrary.org/obo/MP_0000304 abnormal cardiac stroke volume http://purl.obolibrary.org/obo/MP_0002128 abnormal blood circulation anomaly in the volume of blood pushed into the aorta with each beat of the heart http://purl.obolibrary.org/obo/MP_0000313 abnormal cell death http://purl.obolibrary.org/obo/MP_0005621 abnormal cell physiology any anomaly in the cessation of function at the cellular level http://purl.obolibrary.org/obo/MP_0000314 schistocytosis http://purl.obolibrary.org/obo/MP_0002643 poikilocytosis the appearance of poikilocytes in the blood that owe their abnormal shape to fragmentation occurring as the cells flow through damaged small vessels http://purl.obolibrary.org/obo/MP_0000315 hemoglobinuria http://purl.obolibrary.org/obo/MP_0002962 increased urine protein level the presence of hemoglobin in the urine, including certain closely related pigments that are formed from slight alteration of the hemoglobin molecule http://purl.obolibrary.org/obo/MP_0000316 cellular necrosis http://purl.obolibrary.org/obo/MP_0000313 abnormal cell death pathologic death of cells, usually from irreversible damage http://purl.obolibrary.org/obo/MP_0000321 increased bone marrow cell number http://purl.obolibrary.org/obo/MP_0000172 abnormal bone marrow cell number increased number of cells that make up the core cavities of bones when compared to the normal state http://purl.obolibrary.org/obo/MP_0000322 increased granulocyte number http://purl.obolibrary.org/obo/MP_0020201 abnormal granulocyte number greater than expected number of leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils http://purl.obolibrary.org/obo/MP_0000324 increased mast cell number http://purl.obolibrary.org/obo/MP_0020203 abnormal mast cell number greater than expected number of the cells that are found in almost all tissues, containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation http://purl.obolibrary.org/obo/MP_0000327 hemosiderinuria http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis the presence of hemosiderin in the urine; hemosiderin is an intracellular storage form of iron, found in the form of pigmented yellow to brown granules consisting of a complex of ferric hydroxides, polysaccharides, and proteins with an iron content of about 33 per cent by weight http://purl.obolibrary.org/obo/MP_0000328 increased enterocyte cell number http://purl.obolibrary.org/obo/MP_0000481 abnormal enterocyte cell number greater than expected number of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen http://purl.obolibrary.org/obo/MP_0000332 hemoglobinemia http://purl.obolibrary.org/obo/MP_0005416 abnormal circulating protein level the presence of free hemoglobin in the blood plasma, an indication of significant intravascular hemolysis http://purl.obolibrary.org/obo/MP_0000333 decreased bone marrow cell number http://purl.obolibrary.org/obo/MP_0000172 abnormal bone marrow cell number decreased number of cells that make up the core cavities of bones when compared to the normal state http://purl.obolibrary.org/obo/MP_0000334 decreased granulocyte number http://purl.obolibrary.org/obo/MP_0020201 abnormal granulocyte number fewer than expected number of leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils http://purl.obolibrary.org/obo/MP_0000336 decreased mast cell number http://purl.obolibrary.org/obo/MP_0020203 abnormal mast cell number fewer than expected number of the cells that are found in almost all tissues, containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation http://purl.obolibrary.org/obo/MP_0000339 decreased enterocyte cell number http://purl.obolibrary.org/obo/MP_0000481 abnormal enterocyte cell number fewer than expected number of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen http://purl.obolibrary.org/obo/MP_0000341 abnormal bile color http://purl.obolibrary.org/obo/MP_0005085 abnormal gallbladder physiology any change in the color of the bile from the normal yellowish brown or green http://purl.obolibrary.org/obo/MP_0000343 altered response to myocardial infarction http://purl.obolibrary.org/obo/MP_0005164 abnormal response to injury change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors http://purl.obolibrary.org/obo/MP_0000344 absent Cajal-Retzius cell http://purl.obolibrary.org/obo/MP_0008031 decreased Cajal-Retzius cell number the absence of a distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus http://purl.obolibrary.org/obo/MP_0000346 broad head http://purl.obolibrary.org/obo/MP_0011495 abnormal head shape a greater ear- to -ear distance resulting in the appearance of a wide face and a flattened snout http://purl.obolibrary.org/obo/MP_0000348 abnormal aerobic fitness http://purl.obolibrary.org/obo/MP_0005266 abnormal metabolism any change in the metabolism resulting in an altered ability to do physical work; for example, alterations in running capacity http://purl.obolibrary.org/obo/MP_0000350 abnormal cell proliferation http://purl.obolibrary.org/obo/MP_0005621 abnormal cell physiology anomaly in the ability of the a cell population to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0000351 increased cell proliferation http://purl.obolibrary.org/obo/MP_0000350 abnormal cell proliferation increase in the expansion rate of a cell population by cell division http://purl.obolibrary.org/obo/MP_0000352 decreased cell proliferation http://purl.obolibrary.org/obo/MP_0000350 abnormal cell proliferation reduction in the expansion rate of a cell population by cell division http://purl.obolibrary.org/obo/MP_0000358 abnormal cell morphology http://purl.obolibrary.org/obo/MP_0005384 cellular phenotype any structural anomaly of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms http://purl.obolibrary.org/obo/MP_0000359 abnormal mast cell morphology http://purl.obolibrary.org/obo/MP_0002441 abnormal granulocyte morphology any structural anomaly of a cell that is found in almost all tissues, containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation http://purl.obolibrary.org/obo/MP_0000361 decreased mast cell protease storage http://purl.obolibrary.org/obo/MP_0000359 abnormal mast cell morphology reduced amounts of proteolytic enzymes stored in mast cells http://purl.obolibrary.org/obo/MP_0000362 decreased mast cell histamine storage http://purl.obolibrary.org/obo/MP_0000359 abnormal mast cell morphology reduced amounts of histamine stored in mast cells http://purl.obolibrary.org/obo/MP_0000364 abnormal vascular regression http://purl.obolibrary.org/obo/MP_0009577 abnormal developmental vascular remodeling premature regression or persistence of vessels programmed to regress and/or loss of vessels not programmed to regress http://purl.obolibrary.org/obo/MP_0000367 abnormal coat/ hair morphology http://purl.obolibrary.org/obo/MP_0010678 abnormal skin adnexa morphology any anomaly in the color, structure, growth, or texture of the hair http://purl.obolibrary.org/obo/MP_0000370 head blaze http://purl.obolibrary.org/obo/MP_0002075 abnormal coat/hair pigmentation the appearance of a stripe of white fur on the head http://purl.obolibrary.org/obo/MP_0000371 diluted coat color http://purl.obolibrary.org/obo/MP_0002075 abnormal coat/hair pigmentation a coat color that appears lighter in intensity or paler than normal http://purl.obolibrary.org/obo/MP_0000372 irregular coat pigmentation http://purl.obolibrary.org/obo/MP_0002075 abnormal coat/hair pigmentation uneven coloration of the hair http://purl.obolibrary.org/obo/MP_0000373 belly spot http://purl.obolibrary.org/obo/MP_0002938 white spotting the appearance of a round area of white fur on the belly http://purl.obolibrary.org/obo/MP_0000376 folliculitis http://purl.obolibrary.org/obo/MP_0001846 increased inflammatory response inflammatory reaction in hair follicles http://purl.obolibrary.org/obo/MP_0000377 abnormal hair follicle morphology http://purl.obolibrary.org/obo/MP_0010678 abnormal skin adnexa morphology any structural anomaly of the invagination of the epidermis from which the hair shaft develops http://purl.obolibrary.org/obo/MP_0000378 absent hair follicles http://purl.obolibrary.org/obo/MP_0000377 abnormal hair follicle morphology missing epidermal invaginations from which the hair shaft develops http://purl.obolibrary.org/obo/MP_0000379 decreased hair follicle number http://purl.obolibrary.org/obo/MP_0000377 abnormal hair follicle morphology fewer number of the epidermal invaginations from which the hair shaft develops http://purl.obolibrary.org/obo/MP_0000380 small hair follicles http://purl.obolibrary.org/obo/MP_0000377 abnormal hair follicle morphology reduced size of the invagination of the epidermis from which the hair shaft develops http://purl.obolibrary.org/obo/MP_0000381 enlarged hair follicles http://purl.obolibrary.org/obo/MP_0000377 abnormal hair follicle morphology increased size of the epidermal invaginations from which the hair shaft develops http://purl.obolibrary.org/obo/MP_0000382 underdeveloped hair follicles http://purl.obolibrary.org/obo/MP_0003704 abnormal hair follicle development arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops http://purl.obolibrary.org/obo/MP_0000383 abnormal hair follicle orientation http://purl.obolibrary.org/obo/MP_0010678 abnormal skin adnexa morphology misaligned hair follicles; hair follicles that do not orient in a typical pattern http://purl.obolibrary.org/obo/MP_0000384 distorted hair follicle pattern http://purl.obolibrary.org/obo/MP_0000377 abnormal hair follicle morphology twisted or contorted configuration of the arrangement of hair follicles in the skin http://purl.obolibrary.org/obo/MP_0000385 distended hair follicles http://purl.obolibrary.org/obo/MP_0000377 abnormal hair follicle morphology follicles that have swollen or expanded from the skin http://purl.obolibrary.org/obo/MP_0000387 disorganized inner root sheath cells http://purl.obolibrary.org/obo/MP_0010685 abnormal hair follicle inner root sheath morphology disorganization of the epithelial cells that resides in the inner root sheath of the hair follicle http://purl.obolibrary.org/obo/MP_0000388 absent hair follicle inner root sheath http://purl.obolibrary.org/obo/MP_0010685 abnormal hair follicle inner root sheath morphology absence of the multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath; the layers of the inner root sheath include the companion layer, Henle's layer, Huxley's layer and the inner root sheath cuticle http://purl.obolibrary.org/obo/MP_0000389 disorganized outer root sheath cells http://purl.obolibrary.org/obo/MP_0010684 abnormal hair follicle outer root sheath morphology disordered enveloping layer of cells of the hair follicle; surrounds inner root and is continuous with basal and spinous layers of the epidermis http://purl.obolibrary.org/obo/MP_0000390 disorganized matrix sheath cells http://purl.obolibrary.org/obo/MP_0010686 abnormal hair follicle matrix region morphology disordered layer of matrix cells of the hair follicle http://purl.obolibrary.org/obo/MP_0000391 premature hair follicle generation http://purl.obolibrary.org/obo/MP_0003704 abnormal hair follicle development early onset of hair follicle development http://purl.obolibrary.org/obo/MP_0000392 accelerated hair follicle regression http://purl.obolibrary.org/obo/MP_0003875 abnormal hair follicle regression earlier onset of catagen phase during the cyclic transformation of the hair follicle http://purl.obolibrary.org/obo/MP_0000393 persistent hair follicle morphogenesis http://purl.obolibrary.org/obo/MP_0000377 abnormal hair follicle morphology continuous induction of de novo hair follicles in the epidermis http://purl.obolibrary.org/obo/MP_0000394 absent hair follicle melanin granules http://purl.obolibrary.org/obo/MP_0005072 abnormal hair follicle melanin granule morphology absence of the pigment polymers located in the hair follicles http://purl.obolibrary.org/obo/MP_0000396 increased curvature of hairs http://purl.obolibrary.org/obo/MP_0003809 abnormal hair shaft morphology greater bending arch of the distinct C- or S- shaped curvature of the hairs http://purl.obolibrary.org/obo/MP_0000397 abnormal guard hair morphology http://purl.obolibrary.org/obo/MP_0000367 abnormal coat/ hair morphology any structural anomaly of the long, straight truncal hairs that contain two air cells in the medulla http://purl.obolibrary.org/obo/MP_0000398 splitting of guard hairs http://purl.obolibrary.org/obo/MP_0000397 abnormal guard hair morphology intercellular splits and kinks within or along the hair shaft of the long, straight truncal hairs that contain two air cells in the medulla http://purl.obolibrary.org/obo/MP_0000399 increased curvature of guard hairs http://purl.obolibrary.org/obo/MP_0000397 abnormal guard hair morphology greater bending arch of the guard hairs http://purl.obolibrary.org/obo/MP_0000400 abnormal awl hair morphology http://purl.obolibrary.org/obo/MP_0000367 abnormal coat/ hair morphology any structural anomaly of truncal hairs that are straight, but are shorter than guard hairs, and contain two or more air cells in the medulla http://purl.obolibrary.org/obo/MP_0000401 increased curvature of awl hairs http://purl.obolibrary.org/obo/MP_0000400 abnormal awl hair morphology greater bending arch of the awl hairs http://purl.obolibrary.org/obo/MP_0000402 abnormal zigzag hair morphology http://purl.obolibrary.org/obo/MP_0000367 abnormal coat/ hair morphology any structural anomaly or amount of the truncal hairs that have two or more sharp bends with diameter constrictions at the bends, and contain one air cell in the medulla http://purl.obolibrary.org/obo/MP_0000403 increased curvature of zigzag hairs http://purl.obolibrary.org/obo/MP_0000402 abnormal zigzag hair morphology greater bending arch of the zigzag hairs http://purl.obolibrary.org/obo/MP_0000404 decreased curvature of zigzag hairs http://purl.obolibrary.org/obo/MP_0000402 abnormal zigzag hair morphology smaller bending arch of the zigzag hairs http://purl.obolibrary.org/obo/MP_0000405 abnormal auchene hair morphology http://purl.obolibrary.org/obo/MP_0000367 abnormal coat/ hair morphology any structural anomaly of truncal hairs having a single constriction and bend about midway along the hair shaft, and contain two or more air cells in the medulla http://purl.obolibrary.org/obo/MP_0000406 increased curvature of auchene hairs http://purl.obolibrary.org/obo/MP_0000405 abnormal auchene hair morphology greater bending arch of the auchene hairs http://purl.obolibrary.org/obo/MP_0000407 abnormal duvet hair morphology http://purl.obolibrary.org/obo/MP_0000367 abnormal coat/ hair morphology any structural anomaly of the fine under hair of the coat http://purl.obolibrary.org/obo/MP_0000408 absent duvet hair http://purl.obolibrary.org/obo/MP_0000407 abnormal duvet hair morphology absence of the of the fine under hair of the coat http://purl.obolibrary.org/obo/MP_0000410 waved hair http://purl.obolibrary.org/obo/MP_0001510 abnormal coat appearance hair or fur having undulations or a sinusoidal shape http://purl.obolibrary.org/obo/MP_0000411 shiny fur http://purl.obolibrary.org/obo/MP_0001510 abnormal coat appearance fur with a glossy or glistening appearance http://purl.obolibrary.org/obo/MP_0000412 excessive hair http://purl.obolibrary.org/obo/MP_0002073 abnormal hair growth greater amount of body hair compared to controls http://purl.obolibrary.org/obo/MP_0000413 polyphalangy http://purl.obolibrary.org/obo/MP_0005306 abnormal phalanx morphology increased number of phalanges in any of the digits http://purl.obolibrary.org/obo/MP_0000414 alopecia http://purl.obolibrary.org/obo/MP_0002073 abnormal hair growth absence of hair due to loss of hair; not in reference to primary genetic hairlessness but may be due to dietary, stress or secondary to immune condition http://purl.obolibrary.org/obo/MP_0000416 sparse hair http://purl.obolibrary.org/obo/MP_0002073 abnormal hair growth body hair that is less dense; may be due to reduced follicle numbers or due to the inability to retain some of the hairs of the coat over time http://purl.obolibrary.org/obo/MP_0000417 short hair http://purl.obolibrary.org/obo/MP_0002073 abnormal hair growth reduced average length of the hairs http://purl.obolibrary.org/obo/MP_0000418 focal hair loss http://purl.obolibrary.org/obo/MP_0002073 abnormal hair growth focal absence of hair in areas where hair is normally expected; in rodents, often appearing behind the ears and on the tail, resulting in visible patches of skin and uneven spots of hair growth on the body http://purl.obolibrary.org/obo/MP_0000420 ruffled hair http://purl.obolibrary.org/obo/MP_0001510 abnormal coat appearance fuzzy, irregular appearance of the hair http://purl.obolibrary.org/obo/MP_0000421 mottled coat http://purl.obolibrary.org/obo/MP_0005366 variegated coat color coat has spots, streaks, and/or blotches of a different color http://purl.obolibrary.org/obo/MP_0000422 delayed hair appearance http://purl.obolibrary.org/obo/MP_0002073 abnormal hair growth late onset of the first appearance of the fur http://purl.obolibrary.org/obo/MP_0000423 delayed hair regrowth http://purl.obolibrary.org/obo/MP_0000427 abnormal hair cycle slow initiation and asynchrony of the hair growth cycle (anagen) after catagen phase http://purl.obolibrary.org/obo/MP_0000424 retarded hair growth http://purl.obolibrary.org/obo/MP_0002073 abnormal hair growth slow growth of the hair, appears at normal time http://purl.obolibrary.org/obo/MP_0000425 loss of eyelid cilia http://purl.obolibrary.org/obo/MP_0002073 abnormal hair growth inability to retain the eyelashes http://purl.obolibrary.org/obo/MP_0000426 ectopic hair growth http://purl.obolibrary.org/obo/MP_0002073 abnormal hair growth positional abnormality of hair http://purl.obolibrary.org/obo/MP_0000427 abnormal hair cycle http://purl.obolibrary.org/obo/MP_0010680 abnormal skin adnexa physiology aberrant timing of growth and regression of the hair follicles http://purl.obolibrary.org/obo/MP_0000428 abnormal craniofacial morphology http://purl.obolibrary.org/obo/MP_0005382 craniofacial phenotype any structural anomaly of the face or head affecting appearance http://purl.obolibrary.org/obo/MP_0000430 absent maxillary shelf http://purl.obolibrary.org/obo/MP_0004538 abnormal maxillary shelf morphology missing bony projection of the maxilla that normally fuses with palatine shelf to form secondary (hard) palate http://purl.obolibrary.org/obo/MP_0000431 absent palatine bone horizontal plate http://purl.obolibrary.org/obo/MP_0004537 abnormal palatine bone horizontal plate morphology missing bony plate of the palatine bone that normally fuses with maxillary shelf to form secondary (hard) palate http://purl.obolibrary.org/obo/MP_0000432 abnormal head morphology http://purl.obolibrary.org/obo/MP_0005378 growth/size/body phenotype any structural anomaly of the portion of the body containing the brain and organs of sight, hearing, taste, and smell http://purl.obolibrary.org/obo/MP_0000433 microcephaly http://purl.obolibrary.org/obo/MP_0011496 abnormal head size an abnormally small head http://purl.obolibrary.org/obo/MP_0000434 megacephaly http://purl.obolibrary.org/obo/MP_0011496 abnormal head size an abnormally large size of the head http://purl.obolibrary.org/obo/MP_0000435 shortened head http://purl.obolibrary.org/obo/MP_0011495 abnormal head shape reduced anterior-posterior length of the head http://purl.obolibrary.org/obo/MP_0000436 abnormal head movements http://purl.obolibrary.org/obo/MP_0001388 abnormal stationary movement any anomaly in the motion of the portion of the body containing the brain and organs of sight, hearing, taste, and smell http://purl.obolibrary.org/obo/MP_0000437 taut facial appearance http://purl.obolibrary.org/obo/MP_0003743 abnormal facial morphology skin of face has appearance of being drawn or pulled tightly http://purl.obolibrary.org/obo/MP_0000438 abnormal cranium morphology http://purl.obolibrary.org/obo/MP_0002116 abnormal craniofacial bone morphology any structural anomaly of the bones of the head http://purl.obolibrary.org/obo/MP_0000439 enlarged cranium http://purl.obolibrary.org/obo/MP_0010031 abnormal cranium size increased size of the cranium http://purl.obolibrary.org/obo/MP_0000440 domed cranium http://purl.obolibrary.org/obo/MP_0000438 abnormal cranium morphology increased curvature to the hemispherical shape of the upper cranial case http://purl.obolibrary.org/obo/MP_0000441 increased cranium width http://purl.obolibrary.org/obo/MP_0010031 abnormal cranium size having an increased side-to-side, or lateral distance of the cranium http://purl.obolibrary.org/obo/MP_0000443 abnormal snout morphology http://purl.obolibrary.org/obo/MP_0003743 abnormal facial morphology any structural anomaly of the anterior facial part of the face or muzzle containing the oral and nasal regions http://purl.obolibrary.org/obo/MP_0000445 short snout http://purl.obolibrary.org/obo/MP_0000443 abnormal snout morphology reduced length of the anterior facial part of the muzzle http://purl.obolibrary.org/obo/MP_0000446 long snout http://purl.obolibrary.org/obo/MP_0000443 abnormal snout morphology the anterior facial part of the muzzle having a length greater than seen in controls http://purl.obolibrary.org/obo/MP_0000447 flattened snout http://purl.obolibrary.org/obo/MP_0000443 abnormal snout morphology a snout flattened laterally along the whole length without the appearance of distinctive curvature http://purl.obolibrary.org/obo/MP_0000448 pointed snout http://purl.obolibrary.org/obo/MP_0000443 abnormal snout morphology muzzle tapers to a small tip, sharper angle than wild type http://purl.obolibrary.org/obo/MP_0000449 broad nasal bridge http://purl.obolibrary.org/obo/MP_0000443 abnormal snout morphology wider than normal upper part of the ridge of the nose http://purl.obolibrary.org/obo/MP_0000450 absent snout http://purl.obolibrary.org/obo/MP_0000443 abnormal snout morphology absence of the anterior facial part of the face or muzzle containing the oral and nasal regions http://purl.obolibrary.org/obo/MP_0000451 scaly muzzle http://purl.obolibrary.org/obo/MP_0000443 abnormal snout morphology muzzle covered with shedding scales or flakes http://purl.obolibrary.org/obo/MP_0000452 abnormal mouth morphology http://purl.obolibrary.org/obo/MP_0003743 abnormal facial morphology any structural anomaly of the oral cavity http://purl.obolibrary.org/obo/MP_0000453 absent mouth http://purl.obolibrary.org/obo/MP_0000452 abnormal mouth morphology absence of the oral cavity http://purl.obolibrary.org/obo/MP_0000454 abnormal jaw morphology http://purl.obolibrary.org/obo/MP_0005274 abnormal viscerocranium morphology any structural anomaly of the bony framework of the mouth where the teeth are held http://purl.obolibrary.org/obo/MP_0000455 abnormal maxilla morphology http://purl.obolibrary.org/obo/MP_0000454 abnormal jaw morphology any structural anomaly of the upper bony framework of the mouth where the superior teeth are held http://purl.obolibrary.org/obo/MP_0000457 maxilla hypoplasia http://purl.obolibrary.org/obo/MP_0004540 small maxilla underdevelopment or reduced size, usually due to a reduced number of cells, of the upper bony framework of the mouth where the superior teeth are held http://purl.obolibrary.org/obo/MP_0000458 abnormal mandible morphology http://purl.obolibrary.org/obo/MP_0000454 abnormal jaw morphology any structural anomaly of the lower bony framework of the mouth where the inferior teeth are held http://purl.obolibrary.org/obo/MP_0000459 abnormal presacral vertebrae morphology http://purl.obolibrary.org/obo/MP_0000137 abnormal vertebrae morphology any structural anomaly of the vertebrae anterior to the sacrum http://purl.obolibrary.org/obo/MP_0000460 mandible hypoplasia http://purl.obolibrary.org/obo/MP_0004592 small mandible underdevelopment or reduced size, usually due to a reduced number of cells, of the lower bony framework of the mouth where the inferior teeth are held http://purl.obolibrary.org/obo/MP_0000461 decreased presacral vertebrae number http://purl.obolibrary.org/obo/MP_0004645 decreased vertebrae number reduced number of the vertebrae anterior to the sacrum http://purl.obolibrary.org/obo/MP_0000462 abnormal digestive system morphology http://purl.obolibrary.org/obo/MP_0005381 digestive/alimentary phenotype any structural anomaly of the system dedicated to the mechanical, chemical, and enzymatic processing of food http://purl.obolibrary.org/obo/MP_0000464 increased presacral vertebrae number http://purl.obolibrary.org/obo/MP_0004644 increased vertebrae number greater number of the vertebrae anterior to the sacrum http://purl.obolibrary.org/obo/MP_0000465 gastrointestinal hemorrhage http://purl.obolibrary.org/obo/MP_0001914 hemorrhage bleeding in the stomach and/or the intestines http://purl.obolibrary.org/obo/MP_0000466 esophageal epithelium hyperplasia http://purl.obolibrary.org/obo/MP_0000468 abnormal esophageal epithelium morphology overdevelopment or increased size, usually due an increased number of cells in the epithelial layer lining the luminal space of the esophagus http://purl.obolibrary.org/obo/MP_0000467 abnormal esophagus morphology http://purl.obolibrary.org/obo/MP_0000462 abnormal digestive system morphology any structural anomaly of the part of the digestive canal through which food passes from the pharynx to the stomach http://purl.obolibrary.org/obo/MP_0000468 abnormal esophageal epithelium morphology http://purl.obolibrary.org/obo/MP_0000467 abnormal esophagus morphology any structural anomaly of the epithelial layer that lines the luminal space of the esophagus http://purl.obolibrary.org/obo/MP_0000469 abnormal esophageal squamous epithelium morphology http://purl.obolibrary.org/obo/MP_0000468 abnormal esophageal epithelium morphology any structural anomaly of the scaly epithelial layer of the esophagus http://purl.obolibrary.org/obo/MP_0000470 abnormal stomach morphology http://purl.obolibrary.org/obo/MP_0000462 abnormal digestive system morphology any structural anomaly of the hollow, sac-like structure of the digestive canal between the esophagus and the small intestine that functions to emulsify food http://purl.obolibrary.org/obo/MP_0000471 abnormal stomach epithelium morphology http://purl.obolibrary.org/obo/MP_0010792 abnormal stomach mucosa morphology any structural anomaly of the epithelial layer of the stomach http://purl.obolibrary.org/obo/MP_0000472 abnormal stomach squamous epithelium morphology http://purl.obolibrary.org/obo/MP_0000471 abnormal stomach epithelium morphology any structural anomaly of the scaly epithelial layer of the stomach http://purl.obolibrary.org/obo/MP_0000473 abnormal stomach glandular epithelium morphology http://purl.obolibrary.org/obo/MP_0000471 abnormal stomach epithelium morphology any structural anomaly of the gland-containing epithelial layer of the stomach http://purl.obolibrary.org/obo/MP_0000474 abnormal foregut morphology http://purl.obolibrary.org/obo/MP_0003119 abnormal digestive system development any structural anomaly of the anterior portion of the primitive digestive tube of the embryo that lies cephalic to the junction of the yolk stalk, consists of endodermal tissue, and gives rise to the pharynx, lower respiratory system, esophagus, stomach, duodenum proximal to the biliary tract, liver, pancreas, biliary tract, and gall bladder http://purl.obolibrary.org/obo/MP_0000477 abnormal intestine morphology http://purl.obolibrary.org/obo/MP_0000462 abnormal digestive system morphology any structural anomaly of the digestive tube passing from the stomach to the anus, consisting of the small and large intestine divisions http://purl.obolibrary.org/obo/MP_0000478 delayed intestine development http://purl.obolibrary.org/obo/MP_0010158 abnormal intestine development slowed progression to a structurally mature intestine http://purl.obolibrary.org/obo/MP_0000479 abnormal enterocyte morphology http://purl.obolibrary.org/obo/MP_0000488 abnormal intestinal epithelium morphology any structural anomaly of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen http://purl.obolibrary.org/obo/MP_0000480 increased rib number http://purl.obolibrary.org/obo/MP_0000150 abnormal rib morphology greater than normal numbers of the pairs of bony structures that are elements of the body wall http://purl.obolibrary.org/obo/MP_0000481 abnormal enterocyte cell number http://purl.obolibrary.org/obo/MP_0000479 abnormal enterocyte morphology deviation from the normal numbers of enterocytes http://purl.obolibrary.org/obo/MP_0000482 long fibula http://purl.obolibrary.org/obo/MP_0004695 increased length of long bones increased length of the lateral and smaller of bone of the lower leg http://purl.obolibrary.org/obo/MP_0000484 abnormal pulmonary artery morphology http://purl.obolibrary.org/obo/MP_0002191 abnormal artery morphology any structural anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs http://purl.obolibrary.org/obo/MP_0000486 abnormal pulmonary trunk morphology http://purl.obolibrary.org/obo/MP_0002191 abnormal artery morphology any structural anomaly of the region of the pulmonary artery that arises from the right ventricle to the division of the right and left pulmonary artery http://purl.obolibrary.org/obo/MP_0000487 absent enterocytes http://purl.obolibrary.org/obo/MP_0000339 decreased enterocyte cell number absence of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen http://purl.obolibrary.org/obo/MP_0000488 abnormal intestinal epithelium morphology http://purl.obolibrary.org/obo/MP_0000477 abnormal intestine morphology any structural anomaly of the cellular avascular layer of the digestive tube passing from the stomach to the anus http://purl.obolibrary.org/obo/MP_0000489 abnormal large intestine morphology http://purl.obolibrary.org/obo/MP_0000477 abnormal intestine morphology any structural anomaly of the portion of the digestive tube extending from the ileocecal valve to the anus, consisting of the cecum, colon, rectum and anal canal http://purl.obolibrary.org/obo/MP_0000490 abnormal crypts of Lieberkuhn morphology http://purl.obolibrary.org/obo/MP_0002163 abnormal gland morphology any structural anomaly of the tubular intestinal glands found in the mucosal membranes http://purl.obolibrary.org/obo/MP_0000491 crypts of Lieberkuhn abscesses http://purl.obolibrary.org/obo/MP_0000490 abnormal crypts of Lieberkuhn morphology an exudate collection associated with inflammation in the crypts of Lieberkuhn of the intestinal mucosa; often associated with ulcerative colitis http://purl.obolibrary.org/obo/MP_0000492 abnormal rectum morphology http://purl.obolibrary.org/obo/MP_0000489 abnormal large intestine morphology any structural anomaly of the terminal portion of the intestinal tube adjacent to the anus http://purl.obolibrary.org/obo/MP_0000493 rectal prolapse http://purl.obolibrary.org/obo/MP_0000492 abnormal rectum morphology downward movement and external appearance of the rectum through the anus http://purl.obolibrary.org/obo/MP_0000494 abnormal cecum morphology http://purl.obolibrary.org/obo/MP_0000489 abnormal large intestine morphology any structural anomaly of the large sac at the ileum and large intestine junction http://purl.obolibrary.org/obo/MP_0000495 abnormal colon morphology http://purl.obolibrary.org/obo/MP_0000489 abnormal large intestine morphology any structural anomaly of the portion of the large intestine between the cecum and the rectum http://purl.obolibrary.org/obo/MP_0000496 abnormal small intestine morphology http://purl.obolibrary.org/obo/MP_0000477 abnormal intestine morphology any structural anomaly of the portion of the digestive tube between the stomach and the cecum, consisting of the duodenum, ileum and jejunum http://purl.obolibrary.org/obo/MP_0000497 abnormal small intestine placement http://purl.obolibrary.org/obo/MP_0003283 abnormal digestive organ placement different location or arrangement of the small intestinal tract http://purl.obolibrary.org/obo/MP_0000498 absent jejunum http://purl.obolibrary.org/obo/MP_0004002 abnormal jejunum morphology missing portion of the small intestine that extends from the duodenum to the ileum http://purl.obolibrary.org/obo/MP_0000499 absent ileum http://purl.obolibrary.org/obo/MP_0002581 abnormal ileum morphology missing portion of the small intestine that extends from the jejunum to the colon http://purl.obolibrary.org/obo/MP_0000500 small intestinal prolapse http://purl.obolibrary.org/obo/MP_0000496 abnormal small intestine morphology the descent of the small intestine through a weakness in the supporting tissues at the apex of the vagina gives rise to an enterocele, frequently caused by a weakness or separation of the cardinal and sacro-uterine ligaments http://purl.obolibrary.org/obo/MP_0000501 abnormal digestive secretion http://purl.obolibrary.org/obo/MP_0001664 abnormal digestion anomaly in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system http://purl.obolibrary.org/obo/MP_0000503 excessive digestive secretion http://purl.obolibrary.org/obo/MP_0000501 abnormal digestive secretion increase in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system http://purl.obolibrary.org/obo/MP_0000505 decreased digestive secretion http://purl.obolibrary.org/obo/MP_0000501 abnormal digestive secretion reduction in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system http://purl.obolibrary.org/obo/MP_0000507 absent digestive secretion http://purl.obolibrary.org/obo/MP_0000501 abnormal digestive secretion failure to produce and/or release a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system http://purl.obolibrary.org/obo/MP_0000508 right-sided isomerism http://purl.obolibrary.org/obo/MP_0004133 heterotaxia anomaly in the asymmetry of the visceral paired organs (e.g. lungs) such that organs on the left and right side have the morphology normally seen on the right side of the body; this may also be associated with absence of the spleen http://purl.obolibrary.org/obo/MP_0000510 remittent intestinal hemorrhage http://purl.obolibrary.org/obo/MP_0000465 gastrointestinal hemorrhage loss of blood from the intestines that is characterized by temporary periods of abatement http://purl.obolibrary.org/obo/MP_0000511 abnormal intestinal mucosa morphology http://purl.obolibrary.org/obo/MP_0000488 abnormal intestinal epithelium morphology any structural anomaly of the mucous lining of the intestine; this consists of epithelium, lamina propria, and a layer of smooth muscle cells http://purl.obolibrary.org/obo/MP_0000512 intestinal ulcer http://purl.obolibrary.org/obo/MP_0003300 gastrointestinal ulcer lesions in the mucous lining of the intestine http://purl.obolibrary.org/obo/MP_0000516 abnormal renal/urinary system morphology http://purl.obolibrary.org/obo/MP_0005367 renal/urinary system phenotype any structural anomaly of any of the organs or tissues responsible for fluid volume regulation, regulating electrolytes, maintaining acid-base homeostasis, and elimination of water and water soluble waste products in an organism http://purl.obolibrary.org/obo/MP_0000519 hydronephrosis http://purl.obolibrary.org/obo/MP_0004194 abnormal kidney pelvis morphology dilation of the pelvis and calices of one or both kidneys http://purl.obolibrary.org/obo/MP_0000520 absent kidney http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology absence of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine http://purl.obolibrary.org/obo/MP_0000521 abnormal kidney cortex morphology http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology any structural anomaly of the outer portion of the kidney located between the renal capsule and the renal medulla and involved in ultrafiltration; it contains the renal corpuscles, the renal tubules (except for parts of the loop of Henle which descend into the renal medulla), blood vessels and cortical collecting ducts http://purl.obolibrary.org/obo/MP_0000522 kidney cortex cysts http://purl.obolibrary.org/obo/MP_0003675 kidney cysts abnormal membranous sacs appearing in the outer portion of the kidney located between the renal capsule and the renal medulla and involved in ultrafiltration, containing the renal corpuscles, the renal tubules (except for parts of the loop of Henle which descend into the renal medulla), blood vessels and cortical collecting ducts http://purl.obolibrary.org/obo/MP_0000523 cortical renal glomerulopathies http://purl.obolibrary.org/obo/MP_0005325 abnormal renal glomerulus morphology any disease of the capillary plexus in the kidney cortex http://purl.obolibrary.org/obo/MP_0000524 decreased renal tubule number http://purl.obolibrary.org/obo/MP_0002703 abnormal renal tubule morphology fewer of the loops of Henle, the proximal convoluted tubules or the distal convoluted tubules http://purl.obolibrary.org/obo/MP_0000525 renal tubular acidosis http://purl.obolibrary.org/obo/MP_0003031 acidosis a clinical syndrome characterized by the inability to acidify urine http://purl.obolibrary.org/obo/MP_0000526 small inner medullary pyramid http://purl.obolibrary.org/obo/MP_0011333 abnormal kidney inner medulla morphology reduced size of pyramidal masses; contain part of the secreting tubules and collecting tubules http://purl.obolibrary.org/obo/MP_0000527 abnormal kidney development http://purl.obolibrary.org/obo/MP_0003942 abnormal urinary system development any anomaly in the differentiation of the paired organs responsible for urine secretion http://purl.obolibrary.org/obo/MP_0000528 delayed kidney development http://purl.obolibrary.org/obo/MP_0000527 abnormal kidney development late onset of the induction and/or differentiation of the kidney http://purl.obolibrary.org/obo/MP_0000530 abnormal kidney blood vessel morphology http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology any structural anomaly of the network of tubes that carries blood through the organ of excretion http://purl.obolibrary.org/obo/MP_0000531 right pulmonary isomerism http://purl.obolibrary.org/obo/MP_0010853 abnormal lung position or orientation anomaly in the asymmetry of the lung such that the lobes on both the left and right side have the morphology normally seen on the right side of the body http://purl.obolibrary.org/obo/MP_0000532 kidney vascular congestion http://purl.obolibrary.org/obo/MP_0010017 visceral vascular congestion obstruction of the normal flux of blood within the blood vessel network of the organ of secretion http://purl.obolibrary.org/obo/MP_0000533 kidney hemorrhage http://purl.obolibrary.org/obo/MP_0002136 abnormal kidney physiology bleeding in the organ of excretion http://purl.obolibrary.org/obo/MP_0000534 abnormal ureter morphology http://purl.obolibrary.org/obo/MP_0000516 abnormal renal/urinary system morphology any structural anomaly of the tube that conducts the urine from the renal pelvis to the bladder http://purl.obolibrary.org/obo/MP_0000535 ureter urothelium hyperplasia http://purl.obolibrary.org/obo/MP_0011484 abnormal ureter urothelium morphology overdevelopment or increased size, usually due an increased number of cells, of the luminal epithelium of the tube that conducts the urine from the renal pelvis to the bladder http://purl.obolibrary.org/obo/MP_0000536 hydroureter http://purl.obolibrary.org/obo/MP_0000534 abnormal ureter morphology distention of the ureter with urine, due to blockage from any cause http://purl.obolibrary.org/obo/MP_0000537 abnormal urethra morphology http://purl.obolibrary.org/obo/MP_0000516 abnormal renal/urinary system morphology any structural anomaly of the fibromuscular tubular canal through which urine is discharged from the bladder to the exterior via the external urinary meatus; in males, the urethra is joined by the ejaculatory ducts and serves as a passageway for semen during ejaculation, as well as a canal for urine during voiding; in females, the urethra is shorter and emerges above the vaginal opening http://purl.obolibrary.org/obo/MP_0000538 abnormal urinary bladder morphology http://purl.obolibrary.org/obo/MP_0000516 abnormal renal/urinary system morphology any structural anomaly of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys http://purl.obolibrary.org/obo/MP_0000539 distended urinary bladder http://purl.obolibrary.org/obo/MP_0000538 abnormal urinary bladder morphology stretched musculomembranous organ that serves to collect and store urine excreted by the kidneys http://purl.obolibrary.org/obo/MP_0000540 abnormal urinary bladder urothelium morphology http://purl.obolibrary.org/obo/MP_0003630 abnormal urothelium morphology any structural anomaly of the epithelial lining of the luminal space of the urinary bladder http://purl.obolibrary.org/obo/MP_0000542 left-sided isomerism http://purl.obolibrary.org/obo/MP_0004133 heterotaxia anomaly in the asymmetry of the visceral paired organs (e.g. lungs) such that organs on the left and right side have the morphology normally seen on the left side of the body; this may also be associated with the presence of multiple spleens http://purl.obolibrary.org/obo/MP_0000543 absent urinary bladder urothelium http://purl.obolibrary.org/obo/MP_0000540 abnormal urinary bladder urothelium morphology missing the transitional epithelial layer of the urinary bladder http://purl.obolibrary.org/obo/MP_0000544 thin urinary bladder urothelium http://purl.obolibrary.org/obo/MP_0000540 abnormal urinary bladder urothelium morphology decrease in the thickness of the transitional epithelial layer of the urinary bladder http://purl.obolibrary.org/obo/MP_0000547 short limbs http://purl.obolibrary.org/obo/MP_0002109 abnormal limb morphology reduced average length of the extremities http://purl.obolibrary.org/obo/MP_0000548 long limbs http://purl.obolibrary.org/obo/MP_0002109 abnormal limb morphology increased average length of the extremities http://purl.obolibrary.org/obo/MP_0000549 absent limbs http://purl.obolibrary.org/obo/MP_0002109 abnormal limb morphology absence of the projecting paired appendages of an animal trunk, used in particular for movement and grasping; usually denotes the arm and/or legs in mammalian species http://purl.obolibrary.org/obo/MP_0000550 abnormal forelimb morphology http://purl.obolibrary.org/obo/MP_0002109 abnormal limb morphology any structural anomaly of the projecting rostral-most paired appendages of an animal trunk, used in particular for movement and grasping; usually denotes the arm or front limb in mammalian species http://purl.obolibrary.org/obo/MP_0000551 absent forelimb http://purl.obolibrary.org/obo/MP_0000550 abnormal forelimb morphology absence of the projecting rostral-most paired appendages of an animal trunk, used in particular for movement and grasping; usually denotes the arm or front limb in mammalian species http://purl.obolibrary.org/obo/MP_0000552 abnormal radius morphology http://purl.obolibrary.org/obo/MP_0011504 abnormal limb long bone morphology any structural anomaly of the short bone of the lateral forearm http://purl.obolibrary.org/obo/MP_0000553 absent radius http://purl.obolibrary.org/obo/MP_0000552 abnormal radius morphology missing the short bone of the lateral forearm http://purl.obolibrary.org/obo/MP_0000554 abnormal carpal bone morphology http://purl.obolibrary.org/obo/MP_0002115 abnormal limb bone morphology any structural anomaly of the nine nodular bones of the joint between the forelimb bones and the front paws/hands consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids http://purl.obolibrary.org/obo/MP_0000555 absent carpal bone http://purl.obolibrary.org/obo/MP_0000554 abnormal carpal bone morphology absence of any or all of the nine nodular bones of the joint between the forelimb bones and the front paws/hands, consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids http://purl.obolibrary.org/obo/MP_0000556 abnormal hindlimb morphology http://purl.obolibrary.org/obo/MP_0002109 abnormal limb morphology any structural anomaly of the projecting caudal-most paired appendages of an animal trunk, used in particular for movement and grasping; usually denotes the legs or back limbs in mammalian species http://purl.obolibrary.org/obo/MP_0000557 absent hindlimb http://purl.obolibrary.org/obo/MP_0000556 abnormal hindlimb morphology absence of the projecting caudal-most paired appendages of an animal trunk, used in particular for movement and grasping; usually denotes the legs or back limbs in mammalian species http://purl.obolibrary.org/obo/MP_0000558 abnormal tibia morphology http://purl.obolibrary.org/obo/MP_0011504 abnormal limb long bone morphology any structural anomaly of the medial and larger of the two bones of the lower leg http://purl.obolibrary.org/obo/MP_0000559 abnormal femur morphology http://purl.obolibrary.org/obo/MP_0011504 abnormal limb long bone morphology any structural anomaly of the long bone of the thigh http://purl.obolibrary.org/obo/MP_0000561 adactyly http://purl.obolibrary.org/obo/MP_0002110 abnormal digit morphology missing one or more digits, or all digits http://purl.obolibrary.org/obo/MP_0000562 polydactyly http://purl.obolibrary.org/obo/MP_0002110 abnormal digit morphology greater than the normal complement of digits on one or more autopods http://purl.obolibrary.org/obo/MP_0000564 syndactyly http://purl.obolibrary.org/obo/MP_0002110 abnormal digit morphology any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone http://purl.obolibrary.org/obo/MP_0000565 oligodactyly http://purl.obolibrary.org/obo/MP_0002110 abnormal digit morphology congenital condition in which some digits or parts of digits are missing http://purl.obolibrary.org/obo/MP_0000566 synostosis http://purl.obolibrary.org/obo/MP_0005508 abnormal skeleton morphology osseous union of two bones that are not normally connected http://purl.obolibrary.org/obo/MP_0000567 truncation of digits http://purl.obolibrary.org/obo/MP_0002110 abnormal digit morphology absence of the most distal region of the digits http://purl.obolibrary.org/obo/MP_0000568 ectopic digits http://purl.obolibrary.org/obo/MP_0002110 abnormal digit morphology positional abnormality of a digit http://purl.obolibrary.org/obo/MP_0000569 abnormal digit pigmentation http://purl.obolibrary.org/obo/MP_0002110 abnormal digit morphology anomaly in the coloration of the fingers or toes due to changes in the amount, shape, or distribution of cells producing pigment http://purl.obolibrary.org/obo/MP_0000571 interdigital webbing http://purl.obolibrary.org/obo/MP_0000564 syndactyly fold of skin, or web, between the toes that is not normally present http://purl.obolibrary.org/obo/MP_0000572 abnormal autopod morphology http://purl.obolibrary.org/obo/MP_0002109 abnormal limb morphology any structural anomaly of the distal elements of the limb of vertebrates including the pedal or prehensile appendages (e.g. hand, foot, paw, phalanges and/or digits) http://purl.obolibrary.org/obo/MP_0000573 enlarged hind paws http://purl.obolibrary.org/obo/MP_0000572 abnormal autopod morphology larger than average size of the rear feet http://purl.obolibrary.org/obo/MP_0000574 abnormal foot pad morphology http://purl.obolibrary.org/obo/MP_0000572 abnormal autopod morphology any structural anomaly of the body of fat on the foot http://purl.obolibrary.org/obo/MP_0000575 dark foot pads http://purl.obolibrary.org/obo/MP_0009379 abnormal foot pigmentation darker color of the foot pads due to excess pigment http://purl.obolibrary.org/obo/MP_0000576 clubfoot http://purl.obolibrary.org/obo/MP_0000572 abnormal autopod morphology congenital deformation of the feet; foot is plantarflexed, inverted and adducted http://purl.obolibrary.org/obo/MP_0000577 absent eccrine glands http://purl.obolibrary.org/obo/MP_0000675 abnormal eccrine gland morphology absence of the coiled tubular glands situated on the digits and footpads of the paws of rodents, and both in the histologically thick skin of the palmar and plantar surfaces and in the thin skin that covers most of the rest of the body in humans http://purl.obolibrary.org/obo/MP_0000578 ulcerated paws http://purl.obolibrary.org/obo/MP_0000572 abnormal autopod morphology inflammatory, often suppurating lesions on the paws; often become necrotic http://purl.obolibrary.org/obo/MP_0000579 abnormal nail morphology http://purl.obolibrary.org/obo/MP_0010678 abnormal skin adnexa morphology any structural anomaly of any of the horny plates covering the dorsal surface of the distal end of each terminal phalanx of the digits http://purl.obolibrary.org/obo/MP_0000580 deformed nails http://purl.obolibrary.org/obo/MP_0000579 abnormal nail morphology atypical shape or size of the nails http://purl.obolibrary.org/obo/MP_0000582 toenail hyperkeratosis http://purl.obolibrary.org/obo/MP_0000579 abnormal nail morphology keratin extensions from the toenails http://purl.obolibrary.org/obo/MP_0000583 long toenails http://purl.obolibrary.org/obo/MP_0012401 long nails increased length of the toenails http://purl.obolibrary.org/obo/MP_0000585 kinked tail http://purl.obolibrary.org/obo/MP_0002111 abnormal tail morphology a sharp bend or zigzag in the tail http://purl.obolibrary.org/obo/MP_0000588 thick tail http://purl.obolibrary.org/obo/MP_0002111 abnormal tail morphology a tail with a greater diameter than normal http://purl.obolibrary.org/obo/MP_0000589 thin tail http://purl.obolibrary.org/obo/MP_0002111 abnormal tail morphology a tail with a smaller diameter than normal http://purl.obolibrary.org/obo/MP_0000592 short tail http://purl.obolibrary.org/obo/MP_0011999 abnormal tail length reduced length of tail compared to control http://purl.obolibrary.org/obo/MP_0000596 abnormal liver development http://purl.obolibrary.org/obo/MP_0003943 abnormal hepatobiliary system development any anomaly in the differentiation of the bile-secreting organ that is important for detoxification, for fat, carbohydrate, and protein metabolism, and for glycogen storage http://purl.obolibrary.org/obo/MP_0000597 delayed hepatic development http://purl.obolibrary.org/obo/MP_0000596 abnormal liver development late onset of the induction and/or differentiation of the liver http://purl.obolibrary.org/obo/MP_0000598 abnormal liver morphology http://purl.obolibrary.org/obo/MP_0002138 abnormal hepatobiliary system morphology any structural anomaly of the bile-secreting organ that is important for detoxification, for fat, carbohydrate, and protein metabolism, and for glycogen storage http://purl.obolibrary.org/obo/MP_0000599 enlarged liver http://purl.obolibrary.org/obo/MP_0004848 abnormal liver size larger than average size of the liver http://purl.obolibrary.org/obo/MP_0000600 liver hypoplasia http://purl.obolibrary.org/obo/MP_0000601 small liver underdevelopment or reduced size of the liver, usually due to a reduced number of cells, http://purl.obolibrary.org/obo/MP_0000601 small liver http://purl.obolibrary.org/obo/MP_0004848 abnormal liver size reduced size of the liver http://purl.obolibrary.org/obo/MP_0000602 enlarged liver sinusoidal spaces http://purl.obolibrary.org/obo/MP_0008989 abnormal liver sinusoid morphology larger than normal sized blood-filled cavities in the liver http://purl.obolibrary.org/obo/MP_0000603 pale liver http://purl.obolibrary.org/obo/MP_0000598 abnormal liver morphology liver lacking normal coloration, often refers to bloodless condition http://purl.obolibrary.org/obo/MP_0000604 amyloidosis http://purl.obolibrary.org/obo/MP_0005376 homeostasis/metabolism phenotype an accumulation of extracellular amyloid in tissues of the body http://purl.obolibrary.org/obo/MP_0000606 decreased hepatocyte number http://purl.obolibrary.org/obo/MP_0000607 abnormal hepatocyte morphology fewer than normal number of parenchymal liver cells http://purl.obolibrary.org/obo/MP_0000607 abnormal hepatocyte morphology http://purl.obolibrary.org/obo/MP_0008987 abnormal liver lobule morphology any structural anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules http://purl.obolibrary.org/obo/MP_0000608 dissociated hepatocytes http://purl.obolibrary.org/obo/MP_0000607 abnormal hepatocyte morphology disorganization of cohesive hepatocyte structure http://purl.obolibrary.org/obo/MP_0000609 abnormal liver physiology http://purl.obolibrary.org/obo/MP_0002139 abnormal hepatobiliary system physiology any functional anomaly of the bile-secreting organ that is important for detoxification, for fat, carbohydrate, and protein metabolism, and for glycogen storage http://purl.obolibrary.org/obo/MP_0000610 cholestasis http://purl.obolibrary.org/obo/MP_0003252 abnormal bile duct physiology impairment of bile flow due to obstruction in small bile ducts (intrahepatic cholestasis) or obstruction in large bile ducts (extrahepatic cholestasis) http://purl.obolibrary.org/obo/MP_0000611 jaundice http://purl.obolibrary.org/obo/MP_0000609 abnormal liver physiology clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes http://purl.obolibrary.org/obo/MP_0000613 abnormal salivary gland morphology http://purl.obolibrary.org/obo/MP_0002163 abnormal gland morphology any structural anomaly of the saliva-secreting glands of the oral cavity http://purl.obolibrary.org/obo/MP_0000614 absent salivary gland http://purl.obolibrary.org/obo/MP_0000613 abnormal salivary gland morphology missing any of the saliva-secreting glands of the oral cavity http://purl.obolibrary.org/obo/MP_0000615 abnormal palatine gland morphology http://purl.obolibrary.org/obo/MP_0003791 abnormal minor salivary gland morphology any structural anomaly of the salivary gland of the hard palate http://purl.obolibrary.org/obo/MP_0000616 decreased ductal branching in the palatine gland http://purl.obolibrary.org/obo/MP_0009517 abnormal salivary gland duct morphology fewer branches and distal tips of the vesicles of the palatine gland http://purl.obolibrary.org/obo/MP_0000617 increased salivary gland mucosal cell number http://purl.obolibrary.org/obo/MP_0000613 abnormal salivary gland morphology greater than normal number of cells that form mucus in the salivary glands http://purl.obolibrary.org/obo/MP_0000618 small salivary gland http://purl.obolibrary.org/obo/MP_0000613 abnormal salivary gland morphology reduced size of the saliva-secreting glands of the oral cavity http://purl.obolibrary.org/obo/MP_0000619 salivary gland epithelial hyperplasia http://purl.obolibrary.org/obo/MP_0000613 abnormal salivary gland morphology increased cell number in the epithelium of the salivary gland http://purl.obolibrary.org/obo/MP_0000620 narrow salivary ducts http://purl.obolibrary.org/obo/MP_0009517 abnormal salivary gland duct morphology reduced diameter of the tubular canals that carry saliva http://purl.obolibrary.org/obo/MP_0000621 increased salivary adenocarcinoma incidence http://purl.obolibrary.org/obo/MP_0010318 increased salivary gland tumor incidence greater than the expected number of a malignant neoplasm of the secreting cells of the salivary gland, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0000622 increased salivation http://purl.obolibrary.org/obo/MP_0005310 abnormal salivary gland physiology greater than normal amounts of flowing saliva http://purl.obolibrary.org/obo/MP_0000623 decreased salivation http://purl.obolibrary.org/obo/MP_0005310 abnormal salivary gland physiology reduction in the flow, secretion, or amount of saliva http://purl.obolibrary.org/obo/MP_0000624 xerostomia http://purl.obolibrary.org/obo/MP_0003745 abnormal mucosal lining of the mouth dryness of the mouth resulting from reduced salivary secretion http://purl.obolibrary.org/obo/MP_0000627 abnormal mammary gland morphology http://purl.obolibrary.org/obo/MP_0010678 abnormal skin adnexa morphology any structural anomaly of the compound, alveolar and apocrine milk-secreting gland that lies within the breast http://purl.obolibrary.org/obo/MP_0000628 abnormal mammary gland development http://purl.obolibrary.org/obo/MP_0000627 abnormal mammary gland morphology aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity http://purl.obolibrary.org/obo/MP_0000629 absent mammary gland http://purl.obolibrary.org/obo/MP_0009720 abnormal mammary gland pattern missing milk-secreting glands of the breast http://purl.obolibrary.org/obo/MP_0000630 mammary gland hyperplasia http://purl.obolibrary.org/obo/MP_0000627 abnormal mammary gland morphology overdevelopment or increased size of the mammary gland, usually due an increased number of cells http://purl.obolibrary.org/obo/MP_0000631 abnormal neuroendocrine gland morphology http://purl.obolibrary.org/obo/MP_0002163 abnormal gland morphology any structural anomaly of any of the organized aggregations of cells that function as secretory or excretory organs and that release hormones in response to neural stimuli http://purl.obolibrary.org/obo/MP_0000632 abnormal pineal gland morphology http://purl.obolibrary.org/obo/MP_0000840 abnormal epithalamus morphology any structural anomaly of the unpaired epithalamic structure that is shaped like a tiny pine cone and located above the posterior commissure near the level of the habenular complex and the sylvian aqueduct; it is both a circumventricular organ and an endocrine organ that secretes melatonin, a serotonin-derived hormone involved in the regulation of circadian rhythms; the pineal parenchyma, consisting of pinealocytes, interstitial (glial-like) cells, phagocytes and capillaries, is arranged into large folliculi separated by septae of connective tissue and blood vessels http://purl.obolibrary.org/obo/MP_0000633 abnormal pituitary gland morphology http://purl.obolibrary.org/obo/MP_0000830 abnormal diencephalon morphology any structural anomaly of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin from the anterior lobe; melanocyte stimulating hormone from the intermediate lobe and hormones involved in blood pressure regulation from the posterior lobe http://purl.obolibrary.org/obo/MP_0000635 pituitary gland hyperplasia http://purl.obolibrary.org/obo/MP_0000636 enlarged pituitary gland overdevelopment or increased size, usually due to increased cell number, of the pituitary gland http://purl.obolibrary.org/obo/MP_0000636 enlarged pituitary gland http://purl.obolibrary.org/obo/MP_0008936 abnormal pituitary gland size increased size of pituitary gland http://purl.obolibrary.org/obo/MP_0000639 abnormal adrenal gland morphology http://purl.obolibrary.org/obo/MP_0002163 abnormal gland morphology any structural anomaly of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla http://purl.obolibrary.org/obo/MP_0000640 adrenal gland hypoplasia http://purl.obolibrary.org/obo/MP_0002768 small adrenal glands underdevelopment or reduced size, usually due to a reduced number of cells, of the endocrine glands located above the kidney and responsible for hormone and epinephrine secretion http://purl.obolibrary.org/obo/MP_0000642 enlarged adrenal glands http://purl.obolibrary.org/obo/MP_0000639 abnormal adrenal gland morphology increased size of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla http://purl.obolibrary.org/obo/MP_0000643 absent adrenal medulla http://purl.obolibrary.org/obo/MP_0008289 abnormal adrenal medulla morphology absence of the inner portion of the adrenal gland that consists mainly of chromaffin cells which produce, store and secrete neurotransmitters such as epinephrine and norepinephrine http://purl.obolibrary.org/obo/MP_0000644 dextrocardia http://purl.obolibrary.org/obo/MP_0006065 abnormal heart position or orientation congenital defect in which the heart is located on the right side of the thorax instead of on the left side (levocardia, the normal position) http://purl.obolibrary.org/obo/MP_0000645 absent adrenergic chromaffin cells http://purl.obolibrary.org/obo/MP_0003834 abnormal adrenergic chromaffin cell morphology absence of the cells of the medulla of the adrenal gland that are innervated by the splanchnic nerve and that are responsible for epinephrine secretion http://purl.obolibrary.org/obo/MP_0000646 enlarged adrenocortical cells http://purl.obolibrary.org/obo/MP_0008291 abnormal adrenocortical cell morphology larger size of cells of the steroid hormone-producing cells of the cortex of the adrenal gland http://purl.obolibrary.org/obo/MP_0000647 abnormal sebaceous gland morphology http://purl.obolibrary.org/obo/MP_0010678 abnormal skin adnexa morphology any structural anomaly of the holocrine glands that secrete sebum into the hair follicles or in hairless areas into ducts http://purl.obolibrary.org/obo/MP_0000648 absent sebaceous gland http://purl.obolibrary.org/obo/MP_0000647 abnormal sebaceous gland morphology absence of the holocrine glands of the dermis that secrete sebum into the hair follicles http://purl.obolibrary.org/obo/MP_0000649 sebaceous gland atrophy http://purl.obolibrary.org/obo/MP_0000647 abnormal sebaceous gland morphology acquired diminution of the size of the holocrine glands of the dermis that secrete sebum into the hair follicles, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0000650 mesocardia http://purl.obolibrary.org/obo/MP_0006065 abnormal heart position or orientation congenital defect in which the heart is located in the middle of the thorax instead of on the left side (levocardia, the normal position) http://purl.obolibrary.org/obo/MP_0000652 enlarged sebaceous gland http://purl.obolibrary.org/obo/MP_0000647 abnormal sebaceous gland morphology increased size of the sebum secreting glands of the hair shaft http://purl.obolibrary.org/obo/MP_0000653 abnormal sex gland morphology http://purl.obolibrary.org/obo/MP_0002163 abnormal gland morphology any structural anomaly of any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction http://purl.obolibrary.org/obo/MP_0000654 absent sex gland http://purl.obolibrary.org/obo/MP_0000653 abnormal sex gland morphology missing any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction http://purl.obolibrary.org/obo/MP_0000655 dilated sex gland http://purl.obolibrary.org/obo/MP_0000653 abnormal sex gland morphology stretched appearance or excessive fluid in of any of the sex glands http://purl.obolibrary.org/obo/MP_0000659 prostate gland hyperplasia http://purl.obolibrary.org/obo/MP_0004958 enlarged prostate gland overdevelopment or increased size, usually due an increased number of cells in the prostate http://purl.obolibrary.org/obo/MP_0000660 lateral prostate gland hypoplasia http://purl.obolibrary.org/obo/MP_0005147 prostate gland hypoplasia underdevelopment or reduced size, usually due to a reduced number of cells, in the lateral lobe of the prostate http://purl.obolibrary.org/obo/MP_0000661 small prostate gland ventral lobe http://purl.obolibrary.org/obo/MP_0009380 abnormal prostate gland ventral lobe morphology reduced size of the rodent prostate lobe that is located below the ventral aspect of the bladder neck http://purl.obolibrary.org/obo/MP_0000662 abnormal branching of the mammary ductal tree http://purl.obolibrary.org/obo/MP_0009503 abnormal mammary gland duct morphology anomaly in the development of the channels that secrete milk and direct milk to the nipple http://purl.obolibrary.org/obo/MP_0000664 small prostate gland anterior lobe http://purl.obolibrary.org/obo/MP_0001163 abnormal prostate gland anterior lobe morphology reduced size of the rodent prostate lobe that appears as a thin tubular structure, attached to the lesser curvature of the paired seminal vesicles http://purl.obolibrary.org/obo/MP_0000665 decreased ductal branching in the coagulating gland http://purl.obolibrary.org/obo/MP_0009736 abnormal prostate gland branching morphogenesis fewer branches and distal tips of the vesicles of the coagulating gland http://purl.obolibrary.org/obo/MP_0000666 decreased prostate gland duct number http://purl.obolibrary.org/obo/MP_0009734 abnormal prostate gland duct morphology fewer than normal minute canals that pass the prostatic secretions to the urethra http://purl.obolibrary.org/obo/MP_0000671 bulbourethral gland hypoplasia http://purl.obolibrary.org/obo/MP_0001169 abnormal bulbourethral gland morphology underdevelopment or reduced size, usually due to a reduced cell number, of the bulbourethral gland http://purl.obolibrary.org/obo/MP_0000674 abnormal sweat gland morphology http://purl.obolibrary.org/obo/MP_0010678 abnormal skin adnexa morphology any structural anomaly of any of the coil glands of the skin that secrete sweat http://purl.obolibrary.org/obo/MP_0000675 abnormal eccrine gland morphology http://purl.obolibrary.org/obo/MP_0000674 abnormal sweat gland morphology any structural anomaly of the coiled tubular glands situated on the digits and footpads of the paws of rodents, and both in the histologically thick skin of the palmar and plantar surfaces and in the thin skin that covers most of the rest of the body in humans; in mice these are the only sweat glands present http://purl.obolibrary.org/obo/MP_0000676 abnormal water content http://purl.obolibrary.org/obo/MP_0005451 abnormal body composition more or less than the normal total amount of water retained in the body http://purl.obolibrary.org/obo/MP_0000678 abnormal parathyroid gland morphology http://purl.obolibrary.org/obo/MP_0002163 abnormal gland morphology any structural anomaly of one of the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; they secrete parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism http://purl.obolibrary.org/obo/MP_0000679 increased percent water in carcass http://purl.obolibrary.org/obo/MP_0000676 abnormal water content more than the normal total amount of water retained in the body measured post mortem http://purl.obolibrary.org/obo/MP_0000680 absent parathyroid glands http://purl.obolibrary.org/obo/MP_0000678 abnormal parathyroid gland morphology missing the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland, which secrete parathyroid hormone (PTH) http://purl.obolibrary.org/obo/MP_0000681 abnormal thyroid gland morphology http://purl.obolibrary.org/obo/MP_0002163 abnormal gland morphology any structural anomaly of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin http://purl.obolibrary.org/obo/MP_0000683 decreased percent water in carcass http://purl.obolibrary.org/obo/MP_0000676 abnormal water content less than the normal total amount of water retained in the body measured post mortem http://purl.obolibrary.org/obo/MP_0000685 abnormal immune system morphology http://purl.obolibrary.org/obo/MP_0005387 immune system phenotype any structural anomaly in the organs or cells associated with the development and formation of lymphocytes http://purl.obolibrary.org/obo/MP_0000687 small lymphoid organs http://purl.obolibrary.org/obo/MP_0002221 abnormal lymph organ size reduced size of lymphatic tissues http://purl.obolibrary.org/obo/MP_0000688 lymphoid hyperplasia http://purl.obolibrary.org/obo/MP_0002220 large lymphoid organs overdevelopment or increased size, usually due to increased cell number, of lymphatic tissues http://purl.obolibrary.org/obo/MP_0000689 abnormal spleen morphology http://purl.obolibrary.org/obo/MP_0002722 abnormal immune system organ morphology any structural anomaly of the organ that functions to filter blood and to store red corpuscles and platelets http://purl.obolibrary.org/obo/MP_0000690 absent spleen http://purl.obolibrary.org/obo/MP_0000689 abnormal spleen morphology missing organ that functions to filter blood and to store red corpuscles and platelets http://purl.obolibrary.org/obo/MP_0000691 enlarged spleen http://purl.obolibrary.org/obo/MP_0002224 abnormal spleen size increased spleen size http://purl.obolibrary.org/obo/MP_0000692 small spleen http://purl.obolibrary.org/obo/MP_0002224 abnormal spleen size decreased spleen size http://purl.obolibrary.org/obo/MP_0000693 spleen hyperplasia http://purl.obolibrary.org/obo/MP_0000691 enlarged spleen overdevelopment or increased size, usually due to increased cell number, in the spleen http://purl.obolibrary.org/obo/MP_0000694 spleen hypoplasia http://purl.obolibrary.org/obo/MP_0000692 small spleen underdevelopment or reduced size, usually due to a reduced cell number, in the spleen http://purl.obolibrary.org/obo/MP_0000696 abnormal Peyer's patch morphology http://purl.obolibrary.org/obo/MP_0002378 abnormal gut-associated lymphoid tissue morphology any structural anomaly of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densely packed B cell follicles http://purl.obolibrary.org/obo/MP_0000700 abnormal lymph node number http://purl.obolibrary.org/obo/MP_0002339 abnormal lymph node morphology deviation from the normal number of lymph nodes http://purl.obolibrary.org/obo/MP_0000701 abnormal lymph node size http://purl.obolibrary.org/obo/MP_0002339 abnormal lymph node morphology deviation from the normal lymph node size http://purl.obolibrary.org/obo/MP_0000702 enlarged lymph nodes http://purl.obolibrary.org/obo/MP_0000701 abnormal lymph node size lymph nodes of increased size http://purl.obolibrary.org/obo/MP_0000703 abnormal thymus morphology http://purl.obolibrary.org/obo/MP_0002722 abnormal immune system organ morphology any structural anomaly of the primary lymphoid organ that is required for maturation of T cells http://purl.obolibrary.org/obo/MP_0000704 abnormal thymus development http://purl.obolibrary.org/obo/MP_0000703 abnormal thymus morphology anomaly in the formation and/or differentiation of the thymus http://purl.obolibrary.org/obo/MP_0000705 athymia http://purl.obolibrary.org/obo/MP_0000703 abnormal thymus morphology absence of the primary lymphoid organ http://purl.obolibrary.org/obo/MP_0000706 small thymus http://purl.obolibrary.org/obo/MP_0002364 abnormal thymus size reduced size of the thymus http://purl.obolibrary.org/obo/MP_0000708 thymus hyperplasia http://purl.obolibrary.org/obo/MP_0000709 enlarged thymus overdevelopment or increased size, usually due to increased cell number, in the thymus http://purl.obolibrary.org/obo/MP_0000709 enlarged thymus http://purl.obolibrary.org/obo/MP_0002364 abnormal thymus size increased size of thymus http://purl.obolibrary.org/obo/MP_0000711 thymus cortex hypoplasia http://purl.obolibrary.org/obo/MP_0002371 abnormal thymus cortex morphology underdevelopment or reduced size, usually due to a reduced cell number, of the outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes http://purl.obolibrary.org/obo/MP_0000714 increased thymocyte number http://purl.obolibrary.org/obo/MP_0005015 increased T cell number greater than expected number of immature T cells located in the thymus http://purl.obolibrary.org/obo/MP_0000715 decreased thymocyte number http://purl.obolibrary.org/obo/MP_0005018 decreased T cell number fewer than expected number of immature T cells located in the thymus http://purl.obolibrary.org/obo/MP_0000716 abnormal immune system cell morphology http://purl.obolibrary.org/obo/MP_0000685 abnormal immune system morphology any structural anomaly of immune cells http://purl.obolibrary.org/obo/MP_0000717 abnormal lymphocyte cell number http://purl.obolibrary.org/obo/MP_0002619 abnormal lymphocyte morphology deviation from the normal number of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells http://purl.obolibrary.org/obo/MP_0000726 absent lymphocyte http://purl.obolibrary.org/obo/MP_0005016 decreased lymphocyte cell number absence of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells http://purl.obolibrary.org/obo/MP_0000727 absent CD8-positive, alpha-beta T cells http://purl.obolibrary.org/obo/MP_0008079 decreased CD8-positive, alpha-beta T cell number lack of the set of single-positive T cells that express CD8 on their surface http://purl.obolibrary.org/obo/MP_0000729 abnormal myogenesis http://purl.obolibrary.org/obo/MP_0000733 abnormal muscle development anomaly in embryonic formation of muscle cells or fibers http://purl.obolibrary.org/obo/MP_0000730 increased satellite cell number http://purl.obolibrary.org/obo/MP_0000759 abnormal skeletal muscle morphology greater number of unfused cells in muscle that play a role in muscle regeneration http://purl.obolibrary.org/obo/MP_0000731 increased collagen deposition in the muscles http://purl.obolibrary.org/obo/MP_0000733 abnormal muscle development accumulation of collagen within the muscles http://purl.obolibrary.org/obo/MP_0000732 delayed primary myocyte appearance http://purl.obolibrary.org/obo/MP_0000729 abnormal myogenesis development of initial muscle cells at a later time than is normal http://purl.obolibrary.org/obo/MP_0000733 abnormal muscle development http://purl.obolibrary.org/obo/MP_0002108 abnormal muscle morphology any anomaly in the differentiation of muscle tissue http://purl.obolibrary.org/obo/MP_0000734 muscle hypoplasia http://purl.obolibrary.org/obo/MP_0002108 abnormal muscle morphology underdevelopment or reduced size of muscle, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0000736 delayed muscle development http://purl.obolibrary.org/obo/MP_0000733 abnormal muscle development late onset of the induction and/or differentiation of skeletal muscle http://purl.obolibrary.org/obo/MP_0000737 abnormal myotome development http://purl.obolibrary.org/obo/MP_0000729 abnormal myogenesis malformation of or absence of the part of the somite that develops into the musculature http://purl.obolibrary.org/obo/MP_0000738 impaired muscle contractility http://purl.obolibrary.org/obo/MP_0005620 abnormal muscle contractility inability or reduced ability of a muscle to shorten or to develop increased tension http://purl.obolibrary.org/obo/MP_0000740 impaired smooth muscle contractility http://purl.obolibrary.org/obo/MP_0000738 impaired muscle contractility inability or reduced ability of the smooth muscle to shorten or to develop increased tension http://purl.obolibrary.org/obo/MP_0000741 impaired contractility of urinary bladder detrusor smooth muscle http://purl.obolibrary.org/obo/MP_0010386 abnormal urinary bladder physiology inability or reduced ability of the detrusor smooth muscle of the urinary bladder to shorten or to develop increased tension voluntarily or involuntarily; stretching of the smooth muscle fibers by accumulation of urine in the bladder leads to nervous signaling giving the urge to urinate; contraction of the detrusor muscle leads to urination, via emptying of the urine contained in the bladder through the urethra and urine excretion http://purl.obolibrary.org/obo/MP_0000742 impaired contractility of ileal smooth muscle http://purl.obolibrary.org/obo/MP_0004005 impaired contractility of intestinal smooth muscle inability or reduced ability of the ileal smooth muscle to shorten or to develop increased tension http://purl.obolibrary.org/obo/MP_0000743 muscle spasm http://purl.obolibrary.org/obo/MP_0009046 muscle twitch an involuntary and often painful muscle contraction or cramps having a number of causes ranging from nutritional deficiency to serious nervous system conditions http://purl.obolibrary.org/obo/MP_0000745 tremors http://purl.obolibrary.org/obo/MP_0003492 abnormal involuntary movement repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement http://purl.obolibrary.org/obo/MP_0000746 weakness http://purl.obolibrary.org/obo/MP_0004262 abnormal physical strength state of being infirm or less strong than normal http://purl.obolibrary.org/obo/MP_0000747 muscle weakness http://purl.obolibrary.org/obo/MP_0002106 abnormal muscle physiology loss of muscle strength http://purl.obolibrary.org/obo/MP_0000748 progressive muscle weakness http://purl.obolibrary.org/obo/MP_0000747 muscle weakness increasing loss of muscle strength over time http://purl.obolibrary.org/obo/MP_0000749 muscle degeneration http://purl.obolibrary.org/obo/MP_0002108 abnormal muscle morphology pathological deterioration of muscle tissue, often accompanied by loss of function http://purl.obolibrary.org/obo/MP_0000750 abnormal muscle regeneration http://purl.obolibrary.org/obo/MP_0002106 abnormal muscle physiology anomaly in the ability to repair muscle after injury or disease http://purl.obolibrary.org/obo/MP_0000751 myopathy http://purl.obolibrary.org/obo/MP_0002106 abnormal muscle physiology any abnormal condition or disease of the skeletal muscle http://purl.obolibrary.org/obo/MP_0000752 dystrophic muscle http://purl.obolibrary.org/obo/MP_0002108 abnormal muscle morphology progressive weakness and wasting of muscle http://purl.obolibrary.org/obo/MP_0000753 paralysis http://purl.obolibrary.org/obo/MP_0003491 abnormal voluntary movement loss of power of voluntary movement in a muscle through injury or disease of its nerve supply http://purl.obolibrary.org/obo/MP_0000754 paresis http://purl.obolibrary.org/obo/MP_0003491 abnormal voluntary movement partial loss of power of voluntary movement in a muscle through injury or disease of it or its nerve supply http://purl.obolibrary.org/obo/MP_0000755 hindlimb paralysis http://purl.obolibrary.org/obo/MP_0000753 paralysis loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply http://purl.obolibrary.org/obo/MP_0000756 forelimb paralysis http://purl.obolibrary.org/obo/MP_0000753 paralysis loss of power of voluntary movement in muscles of the forelimb through injury or disease of it or its nerve supply http://purl.obolibrary.org/obo/MP_0000757 herniated abdominal wall http://purl.obolibrary.org/obo/MP_0003257 abnormal abdominal wall morphology protrusions through and/or into the abdominal wall often resulting in the extrusion of viscera http://purl.obolibrary.org/obo/MP_0000759 abnormal skeletal muscle morphology http://purl.obolibrary.org/obo/MP_0002108 abnormal muscle morphology any structural anomaly of any of the striated muscle fibers connected at either or both extremities with the bony framework of the body http://purl.obolibrary.org/obo/MP_0000761 thin diaphragm muscle http://purl.obolibrary.org/obo/MP_0002279 abnormal diaphragm morphology reduced thickness of the diaphragm muscle http://purl.obolibrary.org/obo/MP_0000762 abnormal tongue morphology http://purl.obolibrary.org/obo/MP_0000462 abnormal digestive system morphology any structural anomaly of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor http://purl.obolibrary.org/obo/MP_0000763 abnormal filiform papillae morphology http://purl.obolibrary.org/obo/MP_0000764 abnormal tongue epithelium morphology any structural anomaly of the keratinized projections on the dorsal surface of the tongue http://purl.obolibrary.org/obo/MP_0000764 abnormal tongue epithelium morphology http://purl.obolibrary.org/obo/MP_0000762 abnormal tongue morphology any structural anomaly of the epithelial layer of the tongue http://purl.obolibrary.org/obo/MP_0000765 abnormal tongue squamous epithelium morphology http://purl.obolibrary.org/obo/MP_0000764 abnormal tongue epithelium morphology any structural anomaly of the scaly epithelial layer of the tongue http://purl.obolibrary.org/obo/MP_0000766 absent tongue squamous epithelium http://purl.obolibrary.org/obo/MP_0000765 abnormal tongue squamous epithelium morphology missing the scaly epithelial layer of the tongue http://purl.obolibrary.org/obo/MP_0000767 abnormal smooth muscle morphology http://purl.obolibrary.org/obo/MP_0002108 abnormal muscle morphology any structural anomaly of any of the unstriated muscle fibers of the internal organs, blood vessels, hair follicles, etc. http://purl.obolibrary.org/obo/MP_0000771 abnormal brain size http://purl.obolibrary.org/obo/MP_0002152 abnormal brain morphology deviation from the average range of brain size for an organism http://purl.obolibrary.org/obo/MP_0000774 decreased brain size http://purl.obolibrary.org/obo/MP_0000771 abnormal brain size smaller appearance of the brain http://purl.obolibrary.org/obo/MP_0000776 abnormal inferior colliculus morphology http://purl.obolibrary.org/obo/MP_0000899 abnormal corpora quadrigemina morphology any structural anomaly of the paired inferior eminence of the mesencephalic tectum that is involved in preliminary visual processing, and control of eye movements http://purl.obolibrary.org/obo/MP_0000777 increased inferior colliculus size http://purl.obolibrary.org/obo/MP_0000776 abnormal inferior colliculus morphology enlargement of the paired inferior eminence of the mesencephalic tectum http://purl.obolibrary.org/obo/MP_0000778 abnormal nervous system tract morphology http://purl.obolibrary.org/obo/MP_0003632 abnormal nervous system morphology any structural anomaly in the structure of any bundle of myelinated nerve fibers following a defined path through the brain and/or spinal cord http://purl.obolibrary.org/obo/MP_0000780 abnormal corpus callosum morphology http://purl.obolibrary.org/obo/MP_0008540 abnormal cerebrum morphology any structural anomaly of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres http://purl.obolibrary.org/obo/MP_0000781 decreased corpus callosum size http://purl.obolibrary.org/obo/MP_0000780 abnormal corpus callosum morphology smaller thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres http://purl.obolibrary.org/obo/MP_0000783 abnormal forebrain morphology http://purl.obolibrary.org/obo/MP_0002152 abnormal brain morphology any structural anomaly of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions) http://purl.obolibrary.org/obo/MP_0000784 forebrain hypoplasia http://purl.obolibrary.org/obo/MP_0012138 decreased forebrain size underdevelopment or reduced size, usually due to a reduced number of cells, in the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions) http://purl.obolibrary.org/obo/MP_0000785 telencephalon hypoplasia http://purl.obolibrary.org/obo/MP_0000787 abnormal telencephalon morphology underdevelopment or reduced size, usually due to a reduced number of cells, in of the enlarged anteriolateral part of the brain; consists of the paired cerebral hemispheres and olfactory bulbs, the basal ganglia and the connecting structures http://purl.obolibrary.org/obo/MP_0000786 abnormal embryonic neuroepithelial layer differentiation http://purl.obolibrary.org/obo/MP_0004261 abnormal embryonic neuroepithelium morphology abnormal or arrest of differentiation or patterning of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells http://purl.obolibrary.org/obo/MP_0000787 abnormal telencephalon morphology http://purl.obolibrary.org/obo/MP_0000783 abnormal forebrain morphology any structural anomaly of the enlarged anteriolateral part of the brain; consists of the paired cerebral hemispheres and olfactory bulbs, the basal ganglia and the connecting structures, and is considered to be the seat of conscious mental processes; it develops from the anterior-most embryological division of the brain that develops from the prosencephalon http://purl.obolibrary.org/obo/MP_0000788 abnormal cerebral cortex morphology http://purl.obolibrary.org/obo/MP_0008540 abnormal cerebrum morphology any structural anomaly of thin layer of grey matter on the surface of the cerebral hemisphere that develops from the telencephalon and folds into gyri; it is responsible for intellectual faculties and higher mental functions http://purl.obolibrary.org/obo/MP_0000789 thickened cerebral cortex http://purl.obolibrary.org/obo/MP_0000788 abnormal cerebral cortex morphology increased depth of the mantle covering the surface of the cerebral hemispheres http://purl.obolibrary.org/obo/MP_0000790 abnormal stratification in cerebral cortex http://purl.obolibrary.org/obo/MP_0000788 abnormal cerebral cortex morphology abnormal formation or pattern of the layers of the cerebral cortex http://purl.obolibrary.org/obo/MP_0000791 delaminated cerebral cortex http://purl.obolibrary.org/obo/MP_0000788 abnormal cerebral cortex morphology splitting of the layers of the grey cellular mantle covering the surface of the brain http://purl.obolibrary.org/obo/MP_0000792 abnormal cortical marginal zone morphology http://purl.obolibrary.org/obo/MP_0000934 abnormal telencephalon development any structural anomaly of the developing superficial cortical layer located just under the pia matter http://purl.obolibrary.org/obo/MP_0000794 abnormal parietal lobe morphology http://purl.obolibrary.org/obo/MP_0008540 abnormal cerebrum morphology any structural anomaly of the upper central part of the cerebral hemisphere http://purl.obolibrary.org/obo/MP_0000795 abnormal postcentral gyrus morphology http://purl.obolibrary.org/obo/MP_0000794 abnormal parietal lobe morphology any structural anomaly of the area of the parietal lobe that receives general sensation from the body http://purl.obolibrary.org/obo/MP_0000796 abnormal sensory dissociation area morphology http://purl.obolibrary.org/obo/MP_0000794 abnormal parietal lobe morphology any structural anomaly of the area of the parietal lobe that integrates tactile and visual stimuli http://purl.obolibrary.org/obo/MP_0000797 abnormal supramarginal gyrus morphology http://purl.obolibrary.org/obo/MP_0000794 abnormal parietal lobe morphology any structural anomaly of the area of the frontal lobe that is involved in perception based on sensory stimuli http://purl.obolibrary.org/obo/MP_0000798 abnormal frontal lobe morphology http://purl.obolibrary.org/obo/MP_0008540 abnormal cerebrum morphology any structural anomaly of the anterior part of the cerebral hemisphere http://purl.obolibrary.org/obo/MP_0000799 abnormal precentral gyrus morphology http://purl.obolibrary.org/obo/MP_0000798 abnormal frontal lobe morphology any structural anomaly of the area of the frontal lobe that contains the cell bodies of the primary motor pathways http://purl.obolibrary.org/obo/MP_0000800 abnormal supplemetal motor cortex morphology http://purl.obolibrary.org/obo/MP_0000798 abnormal frontal lobe morphology any structural anomaly of the area of the frontal lobe that is involved with integration of voluntary movements and with speech http://purl.obolibrary.org/obo/MP_0000801 abnormal temporal lobe morphology http://purl.obolibrary.org/obo/MP_0008540 abnormal cerebrum morphology any structural anomaly of the lower lateral part of the cerebral hemisphere http://purl.obolibrary.org/obo/MP_0000802 abnormal superior temporal gyrus morphology http://purl.obolibrary.org/obo/MP_0000801 abnormal temporal lobe morphology any structural anomaly of one of three major convolutions of the external surface of the temporal lobe of the cerebral hemispheres that is uppermost and borders the lateral (sylvian) fissure, and contains the primary auditory cortex http://purl.obolibrary.org/obo/MP_0000803 abnormal transverse gyrus of Heschl morphology http://purl.obolibrary.org/obo/MP_0004631 abnormal auditory cortex morphology any structural anomaly of the area of the temporal lobe concerned with hearing http://purl.obolibrary.org/obo/MP_0000804 abnormal occipital lobe morphology http://purl.obolibrary.org/obo/MP_0008540 abnormal cerebrum morphology any structural anomaly of the posterior part of the cerebral hemisphere http://purl.obolibrary.org/obo/MP_0000805 abnormal visual cortex morphology http://purl.obolibrary.org/obo/MP_0000804 abnormal occipital lobe morphology any structural anomaly of the area of the occipital cortex concerned with vision http://purl.obolibrary.org/obo/MP_0000807 abnormal hippocampus morphology http://purl.obolibrary.org/obo/MP_0004166 abnormal limbic system morphology any structural anomaly of the deep lying structure of the cerebrum involved with memory storage and spatial navigation http://purl.obolibrary.org/obo/MP_0000808 abnormal hippocampus development http://purl.obolibrary.org/obo/MP_0003232 abnormal forebrain development improper differentiation of the hippocampus http://purl.obolibrary.org/obo/MP_0000809 absent hippocampus http://purl.obolibrary.org/obo/MP_0000807 abnormal hippocampus morphology missing convoluted brain structure below the cerebral hemispheres; forms part of the limbic system http://purl.obolibrary.org/obo/MP_0000811 hippocampal neuron degeneration http://purl.obolibrary.org/obo/MP_0009939 abnormal hippocampus neuron morphology a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus http://purl.obolibrary.org/obo/MP_0000812 abnormal dentate gyrus morphology http://purl.obolibrary.org/obo/MP_0000807 abnormal hippocampus morphology any structural anomaly of one of two interlocking gyri of the hippocampus formation that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus http://purl.obolibrary.org/obo/MP_0000813 abnormal hippocampus layer morphology http://purl.obolibrary.org/obo/MP_0000807 abnormal hippocampus morphology any structural anomaly of the layers of the laminar structure of the hippocampus http://purl.obolibrary.org/obo/MP_0000814 absent dentate gyrus http://purl.obolibrary.org/obo/MP_0000812 abnormal dentate gyrus morphology lack of the section of the hippocampus normally situated above the gyrus hippocampi and composed of three layers, the molecular, granular, and polymorphic layers http://purl.obolibrary.org/obo/MP_0000815 abnormal Ammon gyrus morphology http://purl.obolibrary.org/obo/MP_0000807 abnormal hippocampus morphology any structural anomaly of one or both of the two interlocking gyri of the hippocampus formation; a circonvolution of rhinencephalon, the grey substance of which is rich in big pyramidal neuronal cells http://purl.obolibrary.org/obo/MP_0000818 abnormal amygdala morphology http://purl.obolibrary.org/obo/MP_0004166 abnormal limbic system morphology any structural anomaly of the almond-shaped body of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe; this area is involved in aggression and fear responses http://purl.obolibrary.org/obo/MP_0000819 abnormal olfactory bulb morphology http://purl.obolibrary.org/obo/MP_0009944 abnormal olfactory lobe morphology any structural anomaly of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex http://purl.obolibrary.org/obo/MP_0000820 abnormal choroid plexus morphology http://purl.obolibrary.org/obo/MP_0013306 abnormal tela choroidea morphology any structural anomaly of the infoldings of blood vessels of the pia mater covered by a thin coat of ependymal cells that form tufted projections into the third, fourth, and lateral ventricles of the brain; choroid plexuses secrete cerebrospinal fluid (CSF) and act as a filtration system, removing metabolic waste, foreign substances, and excess neurotransmitters from the CSF http://purl.obolibrary.org/obo/MP_0000821 choroid plexus hyperplasia http://purl.obolibrary.org/obo/MP_0000820 abnormal choroid plexus morphology overdevelopment or increased size, usually due an increased number of cells located in the infoldings of blood vessels of the pia mater covered by a thin coat of ependymal cells that form tufted projections into the third, fourth, and lateral ventricles of the brain http://purl.obolibrary.org/obo/MP_0000822 abnormal brain ventricle morphology http://purl.obolibrary.org/obo/MP_0002200 abnormal brain ventricular system morphology any structural anomaly of the system of four communicating cavities within the brain that are continuous with the central canal of the spinal cord http://purl.obolibrary.org/obo/MP_0000823 abnormal lateral ventricle morphology http://purl.obolibrary.org/obo/MP_0000822 abnormal brain ventricle morphology any structural anomaly of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle http://purl.obolibrary.org/obo/MP_0000825 dilated lateral ventricles http://purl.obolibrary.org/obo/MP_0012676 dilated brain ventricles the luminal space of the lateral ventricles is increased in volume or area, usually with an increase in contained fluid, in the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle http://purl.obolibrary.org/obo/MP_0000826 abnormal third ventricle morphology http://purl.obolibrary.org/obo/MP_0000830 abnormal diencephalon morphology any structural anomaly of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina http://purl.obolibrary.org/obo/MP_0000827 dilated third ventricle http://purl.obolibrary.org/obo/MP_0012676 dilated brain ventricles the luminal space of the third ventricle is increased in volume or area, usually with an increase in contained fluid, in the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina http://purl.obolibrary.org/obo/MP_0000828 abnormal fourth ventricle morphology http://purl.obolibrary.org/obo/MP_0000841 abnormal hindbrain morphology any structural anomaly of the irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space http://purl.obolibrary.org/obo/MP_0000829 dilated fourth ventricle http://purl.obolibrary.org/obo/MP_0012676 dilated brain ventricles the luminal space of the fourth ventricle is increased in volume or area, usually with an increase in contained fluid, in the irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space http://purl.obolibrary.org/obo/MP_0000830 abnormal diencephalon morphology http://purl.obolibrary.org/obo/MP_0000783 abnormal forebrain morphology any structural anomaly of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex http://purl.obolibrary.org/obo/MP_0000831 diencephalon hyperplasia http://purl.obolibrary.org/obo/MP_0000830 abnormal diencephalon morphology overdevelopment or increased size, usually due an increased number of cells in the rostral portion of the brain stem http://purl.obolibrary.org/obo/MP_0000832 abnormal thalamus morphology http://purl.obolibrary.org/obo/MP_0000830 abnormal diencephalon morphology any structural anomaly of the large ovoid mass of paired bodies containing mostly grey matter and forming part of the lateral wall of the third ventricle of the brain http://purl.obolibrary.org/obo/MP_0000833 thalamus hyperplasia http://purl.obolibrary.org/obo/MP_0000832 abnormal thalamus morphology overdevelopment or increased size, usually due an increased number of cells in the thalamus http://purl.obolibrary.org/obo/MP_0000834 abnormal subthalamus morphology http://purl.obolibrary.org/obo/MP_0000830 abnormal diencephalon morphology any structural anomaly of the anterior part of the diencephalon that lies between the thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis http://purl.obolibrary.org/obo/MP_0000835 abnormal subthalamic nucleus morphology http://purl.obolibrary.org/obo/MP_0006007 abnormal basal ganglion morphology any structural anomaly of the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function http://purl.obolibrary.org/obo/MP_0000836 abnormal substantia nigra morphology http://purl.obolibrary.org/obo/MP_0006007 abnormal basal ganglion morphology any structural anomaly of the layer of grey substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis) http://purl.obolibrary.org/obo/MP_0000837 abnormal hypothalamus morphology http://purl.obolibrary.org/obo/MP_0004166 abnormal limbic system morphology any structural anomaly of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release http://purl.obolibrary.org/obo/MP_0000839 hypothalamus hyperplasia http://purl.obolibrary.org/obo/MP_0000837 abnormal hypothalamus morphology overdevelopment or increased size, usually due an increased number of cells in the hypothalamus http://purl.obolibrary.org/obo/MP_0000840 abnormal epithalamus morphology http://purl.obolibrary.org/obo/MP_0000830 abnormal diencephalon morphology any structural anomaly of the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle http://purl.obolibrary.org/obo/MP_0000841 abnormal hindbrain morphology http://purl.obolibrary.org/obo/MP_0002152 abnormal brain morphology any structural anomaly of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived; the metencephalon (anterior part of the embryonic hindbrain), gives rise to the cerebellum and pons while the myelencephalon (posterior portion of the embryonic hindbrain) gives rise to the medulla oblongata http://purl.obolibrary.org/obo/MP_0000842 absent superior olivary complex http://purl.obolibrary.org/obo/MP_0000848 abnormal pons morphology missing nucleus of neurons on the dorsal part of the lateral surface of the pons; it normally receives projection fibers from the cochlear nuclei and is prominently involved in spatial localization of sound http://purl.obolibrary.org/obo/MP_0000843 absent facial nuclei http://purl.obolibrary.org/obo/MP_0000909 abnormal facial motor nucleus morphology missing nucleus of neurons in the hindbrain; receives fibers from the facial muscles, stapedus muscle and stylohyoid muscle http://purl.obolibrary.org/obo/MP_0000844 abnormal pontine flexure morphology http://purl.obolibrary.org/obo/MP_0006108 abnormal hindbrain development any structural anomaly of the dorsally concave bend of the embryonic rhombencephalon that produces a thinning of the roof of the pons and medulla oblongata and defines the boundary between the metencephalon and myelencephalon in the embryo http://purl.obolibrary.org/obo/MP_0000846 abnormal medulla oblongata morphology http://purl.obolibrary.org/obo/MP_0005277 abnormal brainstem morphology any structural anomaly in the most caudal region of the brainstem that lies directly rostral to the spinal cord; includes regions responsible for autonomic functions such as digestion, breathing and control of heart rate http://purl.obolibrary.org/obo/MP_0000847 abnormal metencephalon morphology http://purl.obolibrary.org/obo/MP_0000841 abnormal hindbrain morphology any structural anomaly of the anterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the cerebellum and the pons Varolii http://purl.obolibrary.org/obo/MP_0000848 abnormal pons morphology http://purl.obolibrary.org/obo/MP_0005277 abnormal brainstem morphology any structural anomaly of the band of nerve fibers in the brain connecting the medulla oblongata and the mesencephalon; this region conveys information about movement from the cerebral hemisphere to the cerebellum http://purl.obolibrary.org/obo/MP_0000849 abnormal cerebellum morphology http://purl.obolibrary.org/obo/MP_0000847 abnormal metencephalon morphology any structural anomaly of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills http://purl.obolibrary.org/obo/MP_0000850 absent cerebellum http://purl.obolibrary.org/obo/MP_0000849 abnormal cerebellum morphology missing the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement http://purl.obolibrary.org/obo/MP_0000851 cerebellum hypoplasia http://purl.obolibrary.org/obo/MP_0000852 small cerebellum underdevelopment or reduced size, usually due to a reduced cell number, in the cerebellum http://purl.obolibrary.org/obo/MP_0000852 small cerebellum http://purl.obolibrary.org/obo/MP_0000849 abnormal cerebellum morphology reduced size of cerebellum http://purl.obolibrary.org/obo/MP_0000853 absent cerebellar foliation http://purl.obolibrary.org/obo/MP_0000857 abnormal cerebellar foliation missing small branches of the cerebellar lobules http://purl.obolibrary.org/obo/MP_0000854 abnormal cerebellum development http://purl.obolibrary.org/obo/MP_0006108 abnormal hindbrain development aberrant or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills http://purl.obolibrary.org/obo/MP_0000855 accelerated formation of intralobular fissures http://purl.obolibrary.org/obo/MP_0000854 abnormal cerebellum development formation of the major fissures of the cerebellum earlier in development than normal http://purl.obolibrary.org/obo/MP_0000856 abnormal cerebellar plate morphology http://purl.obolibrary.org/obo/MP_0000854 abnormal cerebellum development any structural anomaly of the embryonic pseudostratified epithelium of the fourth cerebellar ventricle that eventually forms the vermis and ventral neuroepithelium http://purl.obolibrary.org/obo/MP_0000857 abnormal cerebellar foliation http://purl.obolibrary.org/obo/MP_0009964 abnormal cerebellum lobule morphology any anomaly of the pattern of the ten cerebellar lobules; in mammals, the vermis portion of the cerebellum has a foliation pattern along the AP axis that is distinct from the lateral cerebellar hemispheres and the intermediate zone that separates the vermis from the lateral hemispheres; in addition, each of the ten basic lobules can be subdivided into sublobules but strain and species differences are reported http://purl.obolibrary.org/obo/MP_0000858 altered metastatic potential http://purl.obolibrary.org/obo/MP_0010639 altered tumor pathology altered likelihood of a tumor cell spreading from the site of the initial tumor formation and forming a secondary tumor at another site not directly connected with it http://purl.obolibrary.org/obo/MP_0000859 abnormal somatosensory cortex morphology http://purl.obolibrary.org/obo/MP_0000794 abnormal parietal lobe morphology any structural anomaly of the area of the parietal lobe that lies posterior to the central sulcus and is concerned with receiving and processing general sensations from the body surface http://purl.obolibrary.org/obo/MP_0000860 abnormal primary somatosensory cortex morphology http://purl.obolibrary.org/obo/MP_0000859 abnormal somatosensory cortex morphology any structural anomaly of the area of the postcentral gyrus and central sulcus that is involved in somatic sensation http://purl.obolibrary.org/obo/MP_0000861 disorganized barrel cortex http://purl.obolibrary.org/obo/MP_0003989 abnormal barrel cortex morphology derangement of the pattern of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae http://purl.obolibrary.org/obo/MP_0000862 absent barrels in primary somatosensory cortex http://purl.obolibrary.org/obo/MP_0003989 abnormal barrel cortex morphology missing pattern of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae http://purl.obolibrary.org/obo/MP_0000863 abnormal secondary somatosensory cortex morphology http://purl.obolibrary.org/obo/MP_0000859 abnormal somatosensory cortex morphology any structural anomaly of the area of the upper bank of the lateral sulcus that is involved in somatic sensation http://purl.obolibrary.org/obo/MP_0000864 abnormal cerebellum vermis morphology http://purl.obolibrary.org/obo/MP_0004097 abnormal cerebellar cortex morphology any structural anomaly of the narrow medial zone between the two hemispheres of the cerebellum that is delimited by two longitudinal furrows; it may be continuous with the cerebellar hemispheres in some areas of the cerebellum, e.g., dorsally, or separated by deeper fissues in others (e.g., ventrally); it receives inputs from the spinocerebellar tracts which carry to the vermis information on the position and balance of the torso, and it sends projections to the fastigial nucleus of the cerebellum, which then sends output to the vestibular nuclei http://purl.obolibrary.org/obo/MP_0000865 absent cerebellum vermis http://purl.obolibrary.org/obo/MP_0000864 abnormal cerebellum vermis morphology missing narrow middle zone between the two hemispheres of the cerebellum http://purl.obolibrary.org/obo/MP_0000866 cerebellum vermis hypoplasia http://purl.obolibrary.org/obo/MP_0000864 abnormal cerebellum vermis morphology underdevelopment or reduced size, usually due to a reduced number of cells, in the vermis http://purl.obolibrary.org/obo/MP_0000867 abnormal cerebellum anterior vermis morphology http://purl.obolibrary.org/obo/MP_0009960 abnormal cerebellum anterior lobe morphology any structural anomaly of the anterior portion of the narrow middle zone between the two hemispheres of the cerebellum that is located anterior to the primary fissure http://purl.obolibrary.org/obo/MP_0000868 decreased anterior vermis size http://purl.obolibrary.org/obo/MP_0000867 abnormal cerebellum anterior vermis morphology smaller appearance of the narrow middle zone between the two hemispheres of the anterior lobe of the cerebellum http://purl.obolibrary.org/obo/MP_0000869 abnormal cerebellum posterior vermis morphology http://purl.obolibrary.org/obo/MP_0009962 abnormal cerebellum posterior lobe morphology any structural anomaly of the posterior portion of the narrow middle zone between the two hemispheres of the cerebellum that is located posterior to the primary fissure http://purl.obolibrary.org/obo/MP_0000870 absent cerebellum vermis lobule VIII http://purl.obolibrary.org/obo/MP_0009996 abnormal cerebellum vermis lobule VIII morphology missing part of the inferior vermis of the cerebellum (vermis lobule VIII) http://purl.obolibrary.org/obo/MP_0000871 absent cerebellum vermis lobule IX http://purl.obolibrary.org/obo/MP_0009992 abnormal cerebellum vermis lobule IX morphology missing triangular elevation on the vermis of the cerebellum http://purl.obolibrary.org/obo/MP_0000872 abnormal cerebellum external granule cell layer morphology http://purl.obolibrary.org/obo/MP_0000854 abnormal cerebellum development any structural anomaly of the transient layer of the cerebellar cortex present during development which is composed of the dividing and migrating granule cells http://purl.obolibrary.org/obo/MP_0000873 thin external granule cell layer http://purl.obolibrary.org/obo/MP_0000872 abnormal cerebellum external granule cell layer morphology reduced thickness of the transient layer of the cerebellar cortex present during development which is composed of dividing and migrating granule cells http://purl.obolibrary.org/obo/MP_0000874 irregular external granule cell layer http://purl.obolibrary.org/obo/MP_0000872 abnormal cerebellum external granule cell layer morphology uneven thickness of the transient layer of the cerebellar cortex present during development which is composed of dividing and migrating granule cells http://purl.obolibrary.org/obo/MP_0000875 abnormal cerebellar Purkinje cell layer http://purl.obolibrary.org/obo/MP_0009956 abnormal cerebellar layer morphology any structural anomaly of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells http://purl.obolibrary.org/obo/MP_0000876 Purkinje cell degeneration http://purl.obolibrary.org/obo/MP_0003224 neuron degeneration a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex http://purl.obolibrary.org/obo/MP_0000877 abnormal Purkinje cell morphology http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells http://purl.obolibrary.org/obo/MP_0000878 abnormal Purkinje cell number http://purl.obolibrary.org/obo/MP_0000877 abnormal Purkinje cell morphology different from average number of neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex http://purl.obolibrary.org/obo/MP_0000879 increased Purkinje cell number http://purl.obolibrary.org/obo/MP_0008947 increased neuron number greater than normal number of neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex http://purl.obolibrary.org/obo/MP_0000880 decreased Purkinje cell number http://purl.obolibrary.org/obo/MP_0008948 decreased neuron number fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex http://purl.obolibrary.org/obo/MP_0000884 delaminated Purkinje cell layer http://purl.obolibrary.org/obo/MP_0000875 abnormal cerebellar Purkinje cell layer splitting or disorganization of the layer of large neuron cell bodies between the molecular and granular layers of the cerebellum http://purl.obolibrary.org/obo/MP_0000885 ectopic Purkinje cell http://purl.obolibrary.org/obo/MP_0011723 ectopic neuron Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum http://purl.obolibrary.org/obo/MP_0000886 abnormal cerebellar granule layer morphology http://purl.obolibrary.org/obo/MP_0009956 abnormal cerebellar layer morphology any structural anomaly of the innermost cortical layer of the cerebellum; contains densely packed small neurons, mostly granule cells with some Golgi cells are found at the outer border http://purl.obolibrary.org/obo/MP_0000887 delaminated cerebellar granule layer http://purl.obolibrary.org/obo/MP_0000886 abnormal cerebellar granule layer morphology splitting or disorganization of the deepest of the three layers of the cerebellum that contains granule cells http://purl.obolibrary.org/obo/MP_0000888 absent cerebellar granule layer http://purl.obolibrary.org/obo/MP_0000886 abnormal cerebellar granule layer morphology absence of the innermost cortical layer of the cerebellum; contains densely packed small neurons, mostly granule cells with some Golgi cells are found at the outer border http://purl.obolibrary.org/obo/MP_0000889 abnormal cerebellar molecular layer http://purl.obolibrary.org/obo/MP_0009956 abnormal cerebellar layer morphology any structural anomaly of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells http://purl.obolibrary.org/obo/MP_0000890 thin cerebellar molecular layer http://purl.obolibrary.org/obo/MP_0000889 abnormal cerebellar molecular layer reduced width of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells http://purl.obolibrary.org/obo/MP_0000897 abnormal midbrain morphology http://purl.obolibrary.org/obo/MP_0005277 abnormal brainstem morphology any structural anomaly associated with the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes http://purl.obolibrary.org/obo/MP_0000898 midbrain hyperplasia http://purl.obolibrary.org/obo/MP_0012091 increased midbrain size overdevelopment or increased size, usually due an increased number of cells associated with the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes http://purl.obolibrary.org/obo/MP_0000899 abnormal corpora quadrigemina morphology http://purl.obolibrary.org/obo/MP_0006104 abnormal tectum morphology any structural anomaly of the inferior and superior colliculus http://purl.obolibrary.org/obo/MP_0000900 decreased colliculi size http://purl.obolibrary.org/obo/MP_0000899 abnormal corpora quadrigemina morphology smaller inferior and superior colliculus http://purl.obolibrary.org/obo/MP_0000901 altered position of colliculi http://purl.obolibrary.org/obo/MP_0000899 abnormal corpora quadrigemina morphology positional abnormality of the inferior and superior colliculus http://purl.obolibrary.org/obo/MP_0000904 abnormal superior colliculus morphology http://purl.obolibrary.org/obo/MP_0000899 abnormal corpora quadrigemina morphology any structural anomaly of the paired superior eminence of the mesencephalic tectum that is involved in auditory processing http://purl.obolibrary.org/obo/MP_0000905 increased superior colliculus size http://purl.obolibrary.org/obo/MP_0000904 abnormal superior colliculus morphology enlargement of the paired superior eminence of the mesencephalic tectum http://purl.obolibrary.org/obo/MP_0000906 abnormal trigeminal V mesencephalic nucleus morphology http://purl.obolibrary.org/obo/MP_0000897 abnormal midbrain morphology any structural anomaly of the group of sensory neurons residing in a long, narrow plate in the midbrain; axons pass with the trigeminal nerve http://purl.obolibrary.org/obo/MP_0000907 small mesencephalic trigeminal nucleus http://purl.obolibrary.org/obo/MP_0000906 abnormal trigeminal V mesencephalic nucleus morphology reduced size of the group of sensory neurons residing in a long, narrow plate in the midbrain; axons pass with the trigeminal nerve http://purl.obolibrary.org/obo/MP_0000908 absent mesencephalic trigeminal nucleus http://purl.obolibrary.org/obo/MP_0000906 abnormal trigeminal V mesencephalic nucleus morphology missing group of sensory neurons residing in a long, narrow plate in the midbrain; axons pass with the trigeminal nerve http://purl.obolibrary.org/obo/MP_0000909 abnormal facial motor nucleus morphology http://purl.obolibrary.org/obo/MP_0000848 abnormal pons morphology any structural anomaly of the group of motor neurons residing in the pons that innervate the muscles of facial expression http://purl.obolibrary.org/obo/MP_0000910 small facial motor nucleus http://purl.obolibrary.org/obo/MP_0000909 abnormal facial motor nucleus morphology reduced size of the group of motor neurons residing in the pons that innervate the muscles of facial expression http://purl.obolibrary.org/obo/MP_0000911 abnormal trigeminal motor nucleus morphology http://purl.obolibrary.org/obo/MP_0000848 abnormal pons morphology any structural anomaly of the group of motor neurons innervating the muscles of mastication http://purl.obolibrary.org/obo/MP_0000912 small trigeminal motor nucleus http://purl.obolibrary.org/obo/MP_0000911 abnormal trigeminal motor nucleus morphology reduced size of the group of motor neurons innervating the muscles of mastication http://purl.obolibrary.org/obo/MP_0000913 abnormal brain development http://purl.obolibrary.org/obo/MP_0003861 abnormal nervous system development aberrant or incomplete differentiation of the brain http://purl.obolibrary.org/obo/MP_0000914 exencephaly http://purl.obolibrary.org/obo/MP_0000913 abnormal brain development neurocranial defects resulting in exposure or extrusion of the brain http://purl.obolibrary.org/obo/MP_0000917 obstructive hydrocephaly http://purl.obolibrary.org/obo/MP_0001891 hydroencephaly hydrocephaly due to a block in cerebrospinal fluid flow in the ventricular system http://purl.obolibrary.org/obo/MP_0000919 cranioschisis http://purl.obolibrary.org/obo/MP_0000438 abnormal cranium morphology incomplete closure of the skull, usually congenital http://purl.obolibrary.org/obo/MP_0000920 abnormal myelination http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology any anomaly in the process by which myelin sheaths are formed and maintained around neurons; oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane http://purl.obolibrary.org/obo/MP_0000921 demyelination http://purl.obolibrary.org/obo/MP_0000920 abnormal myelination a partial absence or patchy, incomplete area of a myelin sheath over all or part of an axon or fiber tract due to degeneration or destruction of the myelin sheath http://purl.obolibrary.org/obo/MP_0000923 abnormal roof plate morphology http://purl.obolibrary.org/obo/MP_0002151 abnormal neural tube morphology/development any structural anomaly of the single row of specialized glial cells that occupies the dorsal midline of the developing neural tube along the entire anterior-posterior axis; the roof plate serves as a critical embryonic signaling center for the organization of dorsal neuronal cell types, and acts as a barrier preventing axons and cells migrating across the dorsal midline http://purl.obolibrary.org/obo/MP_0000924 absent roof plate http://purl.obolibrary.org/obo/MP_0000923 abnormal roof plate morphology absence of the single row of specialized glial cells that occupies the dorsal midline of the developing neural tube along the entire anterior-posterior axis; the roof plate serves as a critical embryonic signaling center for the organization of dorsal neuronal cell types, and acts as a barrier preventing axons and cells migrating across the dorsal midline http://purl.obolibrary.org/obo/MP_0000925 abnormal floor plate morphology http://purl.obolibrary.org/obo/MP_0002151 abnormal neural tube morphology/development any structural anomaly of the specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube http://purl.obolibrary.org/obo/MP_0000926 absent floor plate http://purl.obolibrary.org/obo/MP_0000925 abnormal floor plate morphology absence of the specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube http://purl.obolibrary.org/obo/MP_0000927 small floor plate http://purl.obolibrary.org/obo/MP_0000925 abnormal floor plate morphology reduced size of the specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube http://purl.obolibrary.org/obo/MP_0000928 incomplete rostral neuropore closure http://purl.obolibrary.org/obo/MP_0012543 abnormal rostral neuropore morphology arrest of the fusion of the cephalic neural folds http://purl.obolibrary.org/obo/MP_0000929 open neural tube http://purl.obolibrary.org/obo/MP_0003720 abnormal neural tube closure failure of completion of the last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline http://purl.obolibrary.org/obo/MP_0000930 wavy neural tube http://purl.obolibrary.org/obo/MP_0002151 abnormal neural tube morphology/development undulations in the embryonic neural tube http://purl.obolibrary.org/obo/MP_0000932 absent notochord http://purl.obolibrary.org/obo/MP_0002825 abnormal notochord morphology missing axial fibrocellular cord in embryos around which develops the vertebral primordia http://purl.obolibrary.org/obo/MP_0000933 abnormal rhombomere morphology http://purl.obolibrary.org/obo/MP_0006108 abnormal hindbrain development any structural anomaly of any of the transiently divided segments of the developing neural tube of vertebrate embryos found within the hindbrain region in the area that will eventually become the rhombencephalon; the rhombomeres appear as a series of slightly constricted swellings in the neural tube, caudal to the cephalic flexure http://purl.obolibrary.org/obo/MP_0000934 abnormal telencephalon development http://purl.obolibrary.org/obo/MP_0003232 abnormal forebrain development anomaly in the progression of the enlarged anteriolateral part of the brain; consists of the paired cerebral hemispheres and olfactory bulbs, the basal ganglia and the connecting structures, and is considered to be the seat of conscious mental processes; it develops from the anterior-most embryological division of the brain that develops from the prosencephalon http://purl.obolibrary.org/obo/MP_0000935 abnormal folding of telencephalic vesicles http://purl.obolibrary.org/obo/MP_0000934 abnormal telencephalon development malformation of the stereotypic invaginations forming the paired diverticula of the telencephalon http://purl.obolibrary.org/obo/MP_0000936 small embryonic telencephalon http://purl.obolibrary.org/obo/MP_0000934 abnormal telencephalon development reduced size of the paired diverticula of the embryonic telencephalon, from which the forebrain develops http://purl.obolibrary.org/obo/MP_0000937 abnormal motor neuron morphology http://purl.obolibrary.org/obo/MP_0008503 abnormal spinal cord grey matter morphology any structural anomaly of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses http://purl.obolibrary.org/obo/MP_0000938 motor neuron degeneration http://purl.obolibrary.org/obo/MP_0003224 neuron degeneration retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses http://purl.obolibrary.org/obo/MP_0000939 decreased motor neuron number http://purl.obolibrary.org/obo/MP_0008948 decreased neuron number fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses http://purl.obolibrary.org/obo/MP_0000940 abnormal motor neuron innervation pattern http://purl.obolibrary.org/obo/MP_0002184 abnormal innervation any changes in the placement, morphology or number of motor nerve fibers to an effector motor tissue, or failure of refinement of neuronal connections during development http://purl.obolibrary.org/obo/MP_0000947 convulsive seizures http://purl.obolibrary.org/obo/MP_0002064 seizures seizures characterized by uncontrolled motor activity http://purl.obolibrary.org/obo/MP_0000948 nonconvulsive seizures http://purl.obolibrary.org/obo/MP_0002064 seizures seizures without uncontrolled motor activity, but with impairment of consciousness http://purl.obolibrary.org/obo/MP_0000950 abnormal seizure response to pharmacological agent http://purl.obolibrary.org/obo/MP_0009745 abnormal behavioral response to xenobiotic anomaly in the seizure activity response that is brought about by treatment with pharmacological agents http://purl.obolibrary.org/obo/MP_0000951 sporadic seizures http://purl.obolibrary.org/obo/MP_0002064 seizures occasional seizures occurring at irregular intervals http://purl.obolibrary.org/obo/MP_0000952 abnormal CNS glial cell morphology http://purl.obolibrary.org/obo/MP_0003634 abnormal glial cell morphology any structural anomaly of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons http://purl.obolibrary.org/obo/MP_0000953 abnormal oligodendrocyte morphology http://purl.obolibrary.org/obo/MP_0000952 abnormal CNS glial cell morphology any structural anomaly of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS http://purl.obolibrary.org/obo/MP_0000954 decreased oligodendrocyte progenitor number http://purl.obolibrary.org/obo/MP_0000913 abnormal brain development fewer cells that differentiate into a type of glial cell in the central nervous system http://purl.obolibrary.org/obo/MP_0000955 abnormal spinal cord morphology http://purl.obolibrary.org/obo/MP_0003632 abnormal nervous system morphology any structural anomaly of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris http://purl.obolibrary.org/obo/MP_0000956 decreased spinal cord size http://purl.obolibrary.org/obo/MP_0000955 abnormal spinal cord morphology smaller appearance of the spinal cord http://purl.obolibrary.org/obo/MP_0000958 peripheral nervous system degeneration http://purl.obolibrary.org/obo/MP_0002229 neurodegeneration a retrogressive impairment of function or destruction of the ganglia and peripheral nerves that lie outside the brain and spinal cord http://purl.obolibrary.org/obo/MP_0000959 abnormal somatic sensory system morphology http://purl.obolibrary.org/obo/MP_0002752 abnormal somatic nervous system morphology any structural anomaly of the neural tissue involved in the transmission of sensory signals http://purl.obolibrary.org/obo/MP_0000960 abnormal sensory ganglion morphology http://purl.obolibrary.org/obo/MP_0000959 abnormal somatic sensory system morphology any structural anomaly of the clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells http://purl.obolibrary.org/obo/MP_0000961 abnormal dorsal root ganglion morphology http://purl.obolibrary.org/obo/MP_0000960 abnormal sensory ganglion morphology any structural anomaly of a group of sensory nerve cell bodies located on the dorsal spinal roots within the vertebral column http://purl.obolibrary.org/obo/MP_0000962 disorganized dorsal root ganglion http://purl.obolibrary.org/obo/MP_0000961 abnormal dorsal root ganglion morphology loss of segmentation pattern of dorsal root ganglia or loss of regular spacing between the ganglia http://purl.obolibrary.org/obo/MP_0000963 fused dorsal root ganglion http://purl.obolibrary.org/obo/MP_0000961 abnormal dorsal root ganglion morphology loss of DRG spacing pattern and the appearance of two or more ganglia as one http://purl.obolibrary.org/obo/MP_0000964 small dorsal root ganglion http://purl.obolibrary.org/obo/MP_0000961 abnormal dorsal root ganglion morphology reduced size a group of sensory nerve cell bodies located on the dorsal spinal roots within the vertebral column http://purl.obolibrary.org/obo/MP_0000965 abnormal sensory neuron morphology http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology any structural anomaly of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of sensory impulses http://purl.obolibrary.org/obo/MP_0000966 decreased sensory neuron number http://purl.obolibrary.org/obo/MP_0008948 decreased neuron number fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of sensory impulses http://purl.obolibrary.org/obo/MP_0000968 abnormal sensory neuron innervation pattern http://purl.obolibrary.org/obo/MP_0002184 abnormal innervation any changes in the placement, morphology or number of sensory nerve fibers to sensory termini or to spinal cord http://purl.obolibrary.org/obo/MP_0000969 abnormal nociceptor morphology http://purl.obolibrary.org/obo/MP_0000965 abnormal sensory neuron morphology any structural anomaly of any of the peripheral receptors for pain, including receptors sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli http://purl.obolibrary.org/obo/MP_0000970 abnormal polymodal receptor morphology http://purl.obolibrary.org/obo/MP_0000965 abnormal sensory neuron morphology anomaly in a sensory receptor that may be stimulated by mechanical, thermal or chemical means http://purl.obolibrary.org/obo/MP_0000971 abnormal thermoreceptor morphology http://purl.obolibrary.org/obo/MP_0000965 abnormal sensory neuron morphology any structural anomaly of any of the cellular receptors that mediate the sense of temperature; in vertebrates, these are most often located under the skin http://purl.obolibrary.org/obo/MP_0000972 abnormal mechanoreceptor morphology http://purl.obolibrary.org/obo/MP_0000965 abnormal sensory neuron morphology anomaly in the receptors of the body, usually nerve termini, that respond to mechanical pressure or distortion http://purl.obolibrary.org/obo/MP_0000973 abnormal cutaneous/subcutaneous mechanoreceptor morphology http://purl.obolibrary.org/obo/MP_0000972 abnormal mechanoreceptor morphology any structural anomaly of the neuronal receptors that respond to mechanical pressure or distortion in the skin http://purl.obolibrary.org/obo/MP_0000974 abnormal hair guard neuron morphology http://purl.obolibrary.org/obo/MP_0000973 abnormal cutaneous/subcutaneous mechanoreceptor morphology anomaly of the subcutaneous mechanoreceptors that innervate hair follicles of guard hairs, and are involved in the amplification of slow-moving and/or light touch stimuli signals http://purl.obolibrary.org/obo/MP_0000975 absent hair guard neurons http://purl.obolibrary.org/obo/MP_0000974 abnormal hair guard neuron morphology absence of the subcutaneous mechanoreceptors that innervate hair follicles of guard hairs, and are involved in the amplification of slow-moving and/or light touch stimuli signals http://purl.obolibrary.org/obo/MP_0000976 hyperinnervation of hair guard cells http://purl.obolibrary.org/obo/MP_0000974 abnormal hair guard neuron morphology more robust innervation of the subcutaneous mechanoreceptors that innervate hair follicles of guard hairs, and are involved in the amplification of slow-moving and/or light touch stimuli signals http://purl.obolibrary.org/obo/MP_0000977 abnormal hair-tylotrich neuron morphology http://purl.obolibrary.org/obo/MP_0000973 abnormal cutaneous/subcutaneous mechanoreceptor morphology anomaly of the subcutaneous mechanoreceptors that innervate tylotrich hair follicles http://purl.obolibrary.org/obo/MP_0000978 hyperinnervation of hair-tylotrich cells http://purl.obolibrary.org/obo/MP_0000977 abnormal hair-tylotrich neuron morphology more robust innervation of the hair tylotrich cells http://purl.obolibrary.org/obo/MP_0000979 abnormal hair-down neuron morphology http://purl.obolibrary.org/obo/MP_0000973 abnormal cutaneous/subcutaneous mechanoreceptor morphology anomaly of the subcutaneous mechanosensitive D-hair (down-hair) neurons, which innervate hair follicles, and are characterized by a large-amplitude Cav3.2 T-current involved in the amplification of slow-moving and/or light touch stimuli http://purl.obolibrary.org/obo/MP_0000980 absent hair-down neurons http://purl.obolibrary.org/obo/MP_0000979 abnormal hair-down neuron morphology absence of the subcutaneous mechanosensitive D-hair (down-hair) neurons, which innervate hair follicles, and are characterized by a large-amplitude Cav3.2 T-current involved in the amplification of slow-moving and/or light touch stimuli http://purl.obolibrary.org/obo/MP_0000981 hyperinnervation of hair-down cells http://purl.obolibrary.org/obo/MP_0000979 abnormal hair-down neuron morphology more robust innervation of the subcutaneous mechanosensitive D-hair (down-hair) neurons, which innervate hair follicles, and are characterized by a large-amplitude Cav3.2 T-current involved in the amplification of slow-moving and/or light touch stimuli http://purl.obolibrary.org/obo/MP_0000982 abnormal Meissner's corpuscle morphology http://purl.obolibrary.org/obo/MP_0000973 abnormal cutaneous/subcutaneous mechanoreceptor morphology any structural anomaly of any of the numerous oval bodies found in the dermal papillae of glabrous skin that transmit information about skin motion and slipping objects http://purl.obolibrary.org/obo/MP_0000983 enlarged Meissner's corpuscles http://purl.obolibrary.org/obo/MP_0000982 abnormal Meissner's corpuscle morphology larger than average size of any of the numerous oval bodies found in the dermal papillae of glabrous skin that transmit information about skin motion and slipping objects http://purl.obolibrary.org/obo/MP_0000984 hyperinnervation of Meissner's corpuscle http://purl.obolibrary.org/obo/MP_0000982 abnormal Meissner's corpuscle morphology more robust supply of nerve fibers connected to any part of any of the numerous oval bodies found in the dermal papillae of glabrous skin that transmit information about skin motion and slipping objects http://purl.obolibrary.org/obo/MP_0000985 abnormal Merkel's receptor morphology http://purl.obolibrary.org/obo/MP_0000973 abnormal cutaneous/subcutaneous mechanoreceptor morphology any structural anomaly of the modified epidermal cells located in the stratum basale and found mostly in areas where sensory perception is acute http://purl.obolibrary.org/obo/MP_0000986 increased Merkel's receptor number http://purl.obolibrary.org/obo/MP_0006006 increased sensory neuron number greater than the normal number of the modified epidermal cells located in the stratum basale and found mostly in areas where sensory perception is acute http://purl.obolibrary.org/obo/MP_0000987 hyperinnervation of Merkel's receptor http://purl.obolibrary.org/obo/MP_0000985 abnormal Merkel's receptor morphology more robust supply of nerve fibers connected to the modified epidermal cells located in the stratum basale and found mostly in areas where sensory perception is acute http://purl.obolibrary.org/obo/MP_0000988 abnormal pacinian corpuscle morphology http://purl.obolibrary.org/obo/MP_0000973 abnormal cutaneous/subcutaneous mechanoreceptor morphology any structural anomaly of any of the rapidly adapting mechanoreceptors found in subcutaneous tissue beneath both hairy and glabrous skin, and which normally contain an afferent nerve fiber surrounded by a capsule with multiple concentric layers; trasmit signals generated by vibrations when grasping an object http://purl.obolibrary.org/obo/MP_0000989 abnormal Ruffini's corpuscle morphology http://purl.obolibrary.org/obo/MP_0000973 abnormal cutaneous/subcutaneous mechanoreceptor morphology any structural anomaly in the sensory cells in the subcutaneous tissue of the digits specialized to transduce mechanical stimuli, skin stretch, direction of object motion, hand shape and finger position http://purl.obolibrary.org/obo/MP_0000990 abnormal skeletal muscle mechanoreceptor morphology http://purl.obolibrary.org/obo/MP_0000972 abnormal mechanoreceptor morphology any structural anomaly of the receptors that respond to mechanical pressure or distortion in the skeletal muscle http://purl.obolibrary.org/obo/MP_0000991 abnormal primary muscle spindle morphology http://purl.obolibrary.org/obo/MP_0004069 abnormal muscle spindle morphology any structural anomaly of the sensory organ in muscle; involved in the stretch reflex and sensitive to stretch velocity http://purl.obolibrary.org/obo/MP_0000992 absent primary muscle spindle http://purl.obolibrary.org/obo/MP_0000991 abnormal primary muscle spindle morphology missing sensory organ in muscle; involved in the stretch reflex and is sensitive to stretch velocity http://purl.obolibrary.org/obo/MP_0000993 partial loss of primary muscle spindle http://purl.obolibrary.org/obo/MP_0000991 abnormal primary muscle spindle morphology missing a portion of the sensory organ in muscle; involved in the stretch reflex and is sensitive to stretch velocity http://purl.obolibrary.org/obo/MP_0000994 abnormal secondary muscle spindle morphology http://purl.obolibrary.org/obo/MP_0004069 abnormal muscle spindle morphology any structural anomaly of the sensory organ in muscle; involved in the stretch reflex and not sensitive to stretch velocity http://purl.obolibrary.org/obo/MP_0000995 absent secondary muscle spindle http://purl.obolibrary.org/obo/MP_0000994 abnormal secondary muscle spindle morphology lack of the sensory organ in muscle; involved in the stretch reflex and is not sensitive to stretch velocity http://purl.obolibrary.org/obo/MP_0000996 partial loss of secondary muscle spindle http://purl.obolibrary.org/obo/MP_0000994 abnormal secondary muscle spindle morphology missing a portion of the sensory organ in muscle; involved in the stretch reflex and is not sensitive to stretch velocity http://purl.obolibrary.org/obo/MP_0000997 abnormal joint capsule morphology http://purl.obolibrary.org/obo/MP_0002932 abnormal joint morphology any structural anomaly of the sac or its contents that encloses the articulating ends of bones participating in a synovial joint http://purl.obolibrary.org/obo/MP_0000998 absent joint capsule http://purl.obolibrary.org/obo/MP_0000997 abnormal joint capsule morphology missing sac that encloses the articulating ends of bones participating in a synovial joint http://purl.obolibrary.org/obo/MP_0000999 abnormal golgi tendon organ morphology http://purl.obolibrary.org/obo/MP_0000990 abnormal skeletal muscle mechanoreceptor morphology any structural anomaly of the sensory organ in muscle that is involved in regulating muscle tension http://purl.obolibrary.org/obo/MP_0001000 absent golgi tendon organ http://purl.obolibrary.org/obo/MP_0000999 abnormal golgi tendon organ morphology missing sensory organ in muscle that is involved in regulating muscle tension http://purl.obolibrary.org/obo/MP_0001001 abnormal chemoreceptor morphology http://purl.obolibrary.org/obo/MP_0000965 abnormal sensory neuron morphology any structural anomaly of any of the cells specialized to detect chemical substances and relay that information centrally in the nervous system http://purl.obolibrary.org/obo/MP_0001002 abnormal taste bud morphology http://purl.obolibrary.org/obo/MP_0005500 abnormal gustatory system morphology any structural anomaly of the small sensory organs located in the tongue that contain gustatory receptor cells, basal cells, and supporting cells http://purl.obolibrary.org/obo/MP_0001003 abnormal olfactory receptor morphology http://purl.obolibrary.org/obo/MP_0006092 abnormal olfactory sensory neuron morphology any structural anomaly of the proteins, usually projecting from the cilia of olfactory receptor neurons, that specifically bind odorant molecules and trigger responses in the specialized neurons of the olfactory epithelium http://purl.obolibrary.org/obo/MP_0001004 abnormal retinal photoreceptor morphology http://purl.obolibrary.org/obo/MP_0003728 abnormal retinal photoreceptor layer morphology any structural anomaly of a cell specialized to detect and transduce light, including rods and cones of the retina http://purl.obolibrary.org/obo/MP_0001005 abnormal retinal rod cell morphology http://purl.obolibrary.org/obo/MP_0001004 abnormal retinal photoreceptor morphology any structural anomaly of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane; rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision http://purl.obolibrary.org/obo/MP_0001006 abnormal retinal cone cell morphology http://purl.obolibrary.org/obo/MP_0001004 abnormal retinal photoreceptor morphology any structural anomaly of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment; cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision http://purl.obolibrary.org/obo/MP_0001007 abnormal sympathetic system morphology http://purl.obolibrary.org/obo/MP_0002751 abnormal autonomic nervous system morphology any structural anomaly of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body's response to stressful situations http://purl.obolibrary.org/obo/MP_0001008 abnormal sympathetic ganglion morphology http://purl.obolibrary.org/obo/MP_0001007 abnormal sympathetic system morphology any structural anomaly of the ganglia of the sympathetic nervous system including the paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia http://purl.obolibrary.org/obo/MP_0001009 paravertebral ganglia hyperplasia http://purl.obolibrary.org/obo/MP_0008317 abnormal paravertebral ganglion morphology overdevelopment or increased size, usually due to increased cell number, of the groups of postsynaptic neurons located at intervals along the sympathetic trunk, including the superior cervical, middle cervical and stellate (cervicothoracic) ganglia as well as the thoracic, lumbar and sacral ganglia http://purl.obolibrary.org/obo/MP_0001010 prevertebral ganglia hyperplasia http://purl.obolibrary.org/obo/MP_0008316 abnormal prevertebral ganglion morphology overdevelopment or increased size, usually due to increased cell number, of the sympathetic ganglia located in front of the vertebral column and are associated with the major branches of the abdominal aorta; these include the celiac, aorticorenal, superior and inferior mesenteric ganglia http://purl.obolibrary.org/obo/MP_0001011 abnormal superior cervical ganglion morphology http://purl.obolibrary.org/obo/MP_0008317 abnormal paravertebral ganglion morphology any structural anomaly of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck http://purl.obolibrary.org/obo/MP_0001012 superior cervical ganglion hypertrophy http://purl.obolibrary.org/obo/MP_0001013 enlarged superior cervical ganglion increase in the size of cells in the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck http://purl.obolibrary.org/obo/MP_0001013 enlarged superior cervical ganglion http://purl.obolibrary.org/obo/MP_0001011 abnormal superior cervical ganglion morphology increased size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck http://purl.obolibrary.org/obo/MP_0001014 absent superior cervical ganglion http://purl.obolibrary.org/obo/MP_0001011 abnormal superior cervical ganglion morphology lack of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck http://purl.obolibrary.org/obo/MP_0001015 small superior cervical ganglion http://purl.obolibrary.org/obo/MP_0001011 abnormal superior cervical ganglion morphology reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck http://purl.obolibrary.org/obo/MP_0001016 abnormal middle cervical ganglion morphology http://purl.obolibrary.org/obo/MP_0008317 abnormal paravertebral ganglion morphology any structural anomaly of the small ganglion located at the level of the cricoid cartilage of the laryngeal wall http://purl.obolibrary.org/obo/MP_0001017 abnormal stellate ganglion morphology http://purl.obolibrary.org/obo/MP_0008317 abnormal paravertebral ganglion morphology any structural anomaly of the group of neurons formed by the fusion of the inferior cervical and first thoracic ganglia http://purl.obolibrary.org/obo/MP_0001019 abnormal L4 dorsal root ganglion morphology http://purl.obolibrary.org/obo/MP_0006404 abnormal lumbar dorsal root ganglion morphology any structural anomaly of the group of nerve cell bodies located on the dorsal spinal roots within the vertebral column at the level of the fourth lumbar vertebra http://purl.obolibrary.org/obo/MP_0001020 L4 dorsal root ganglion hypertrophy http://purl.obolibrary.org/obo/MP_0001019 abnormal L4 dorsal root ganglion morphology increased bulk size of the L4 spinal ganglion http://purl.obolibrary.org/obo/MP_0001021 small L4 dorsal root ganglion http://purl.obolibrary.org/obo/MP_0001019 abnormal L4 dorsal root ganglion morphology reduced size of the L4 spinal ganglion http://purl.obolibrary.org/obo/MP_0001022 abnormal L5 dorsal root ganglion morphology http://purl.obolibrary.org/obo/MP_0006404 abnormal lumbar dorsal root ganglion morphology any structural anomaly of the group of nerve cell bodies located on the dorsal spinal roots within the vertebral column at the level of the fifth lumbar vertebra http://purl.obolibrary.org/obo/MP_0001023 L5 dorsal root ganglion hypertrophy http://purl.obolibrary.org/obo/MP_0001022 abnormal L5 dorsal root ganglion morphology increased bulk size of L5 spinal ganglion http://purl.obolibrary.org/obo/MP_0001024 small L5 dorsal root ganglion http://purl.obolibrary.org/obo/MP_0001022 abnormal L5 dorsal root ganglion morphology reduced size of the L5 spinal ganglion http://purl.obolibrary.org/obo/MP_0001025 abnormal sympathetic neuron morphology http://purl.obolibrary.org/obo/MP_0001007 abnormal sympathetic system morphology any structural anomaly of any of the neurons of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body's response to stressful situations http://purl.obolibrary.org/obo/MP_0001026 abnormal adrenergic neuron morphology http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology any structural anomaly of the neurons which secrete norepinephrine as a neurotransmitter; adrenergic neurons are mostly sympathetic postganglionic nerves plus some within specific brainstem foci http://purl.obolibrary.org/obo/MP_0001032 abnormal peptidergic neuron morphology http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology any structural anomaly of the nerve fibers that release small peptides as their neurotransmitter http://purl.obolibrary.org/obo/MP_0001033 abnormal parasympathetic system morphology http://purl.obolibrary.org/obo/MP_0002751 abnormal autonomic nervous system morphology any structural anomaly of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and generally acts to conserve resources and restore homeostasis, often with effects reciprocal to the sympathetic nervous system http://purl.obolibrary.org/obo/MP_0001034 abnormal parasympathetic ganglion morphology http://purl.obolibrary.org/obo/MP_0001033 abnormal parasympathetic system morphology any structural anomaly of the ganglia of the parasympathetic nervous system, including the ciliary, pterygopalatine, submandibular, and otic ganglia in the cranial region and intrinsic (terminal) ganglia associated with target organs in the thorax and abdomen http://purl.obolibrary.org/obo/MP_0001035 abnormal submandibular ganglion morphology http://purl.obolibrary.org/obo/MP_0001034 abnormal parasympathetic ganglion morphology any structural anomaly of the ganglion associated with the lingual nerve that provides postsynaptic fibers to the submandibular and sublingual glands http://purl.obolibrary.org/obo/MP_0001036 small submandibular ganglion http://purl.obolibrary.org/obo/MP_0001035 abnormal submandibular ganglion morphology reduced size of the small parasympathetic ganglion of the lingual nerve http://purl.obolibrary.org/obo/MP_0001037 abnormal parasympathetic neuron morphology http://purl.obolibrary.org/obo/MP_0001033 abnormal parasympathetic system morphology any structural anomaly of the neurons of the autonomic nervous system that are responsible for innervation of smooth muscle, cardiac muscle and glands http://purl.obolibrary.org/obo/MP_0001038 abnormal cholinergic neuron morphology http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology any structural anomaly of the neurons that utilize acetylcholine as a neurotransmitter, including include alpha-motor neurons of the spinal cord, cranial nerves innervating skeletal muscle, preganglionic sympathetic and postganglionic parasympathetic neurons http://purl.obolibrary.org/obo/MP_0001040 deficient enteric cholinergic innervation http://purl.obolibrary.org/obo/MP_0001049 abnormal enteric cholinergic innervation defective or incomplete supply of nerve fibers to the intestinal system that utilize acetylcholine as a neurotransmitter http://purl.obolibrary.org/obo/MP_0001044 abnormal enteric nervous system morphology http://purl.obolibrary.org/obo/MP_0002751 abnormal autonomic nervous system morphology any structural anomaly of the part of the autonomic nervous system that innervates the gastrointestinal tract, the pancreas, and the gallbladder and can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport http://purl.obolibrary.org/obo/MP_0001045 abnormal enteric ganglia morphology http://purl.obolibrary.org/obo/MP_0001044 abnormal enteric nervous system morphology any structural anomaly or deformity of the groups of nerve cell bodies associated with the enteric neurons http://purl.obolibrary.org/obo/MP_0001046 abnormal enteric neuron morphology http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology any structural anomaly of the neurons that innervate the esophagus, stomach, small and large bowel http://purl.obolibrary.org/obo/MP_0001047 abnormal enteric cholinergic neuron morphology http://purl.obolibrary.org/obo/MP_0001046 abnormal enteric neuron morphology any structural anomaly of the neurons that utilize acetylcholine as a neurotransmitter and innervate the esophagus, stomach, small and large bowel http://purl.obolibrary.org/obo/MP_0001048 absent enteric neurons http://purl.obolibrary.org/obo/MP_0001046 abnormal enteric neuron morphology absence of the neurons that innervate the esophagus, stomach, small and large bowel http://purl.obolibrary.org/obo/MP_0001049 abnormal enteric cholinergic innervation http://purl.obolibrary.org/obo/MP_0001047 abnormal enteric cholinergic neuron morphology any structural anomaly of the supply of nerve fibers that utilize acetylcholine as a neurotransmitter to the intestinal system http://purl.obolibrary.org/obo/MP_0001051 abnormal somatic motor system morphology http://purl.obolibrary.org/obo/MP_0002752 abnormal somatic nervous system morphology any structural anomaly of the neural tissue involved in the transmission of motor signals http://purl.obolibrary.org/obo/MP_0001052 abnormal innervation pattern to muscle http://purl.obolibrary.org/obo/MP_0002184 abnormal innervation any changes in the placement, morphology or number of sensory, sympathetic or motor nerves to targets in muscle http://purl.obolibrary.org/obo/MP_0001053 abnormal neuromuscular synapse morphology http://purl.obolibrary.org/obo/MP_0009538 abnormal synapse morphology any structural anomaly of the membrane to membrane contact of a motor axon and a muscle myofiber that is responsible for the transmission of nerve impulses http://purl.obolibrary.org/obo/MP_0001054 failure of neuromuscular synapse presynaptic differentiation http://purl.obolibrary.org/obo/MP_0001053 abnormal neuromuscular synapse morphology inability of nerve terminals to find target and/or form terminal arbors for synaptic transmission at the neuromuscular synapse http://purl.obolibrary.org/obo/MP_0001055 failure of neuromuscular synapse postsynaptic differentiation http://purl.obolibrary.org/obo/MP_0001053 abnormal neuromuscular synapse morphology inability of an effector cell to form a differentiated postsynaptic membrane in response to innervation at the neuromuscular synapse http://purl.obolibrary.org/obo/MP_0001056 abnormal cranial nerve morphology http://purl.obolibrary.org/obo/MP_0002752 abnormal somatic nervous system morphology any structural anomaly of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves http://purl.obolibrary.org/obo/MP_0001059 optic nerve atrophy http://purl.obolibrary.org/obo/MP_0001330 abnormal optic nerve morphology acquired diminution of the size of the second cranial nerve which is responsible for conveying visual information from the retina to the brain, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0001061 abnormal oculomotor nerve morphology http://purl.obolibrary.org/obo/MP_0001056 abnormal cranial nerve morphology any structural anomaly of the third cranial nerve, which normally sends motor fibers to the levator muscles of the eyelid and to the superior rectus, inferior rectus, and inferior oblique muscles of the eye; and also sends parasympathetic efferents to the muscles controlling pupillary constriction and accommodation http://purl.obolibrary.org/obo/MP_0001062 absent oculomotor nerve http://purl.obolibrary.org/obo/MP_0001061 abnormal oculomotor nerve morphology missing nerve of the extraocular muscles, iris and ciliary body http://purl.obolibrary.org/obo/MP_0001063 abnormal trochlear nerve morphology http://purl.obolibrary.org/obo/MP_0001056 abnormal cranial nerve morphology any structural anomaly of the fourth cranial nerve, which normally carries the motor innervation of the superior oblique muscles of the eye http://purl.obolibrary.org/obo/MP_0001064 absent trochlear nerve http://purl.obolibrary.org/obo/MP_0001063 abnormal trochlear nerve morphology absence of the fourth cranial nerve, which normally carries the motor innervation of the superior oblique muscles of the eye http://purl.obolibrary.org/obo/MP_0001065 abnormal trigeminal nerve morphology http://purl.obolibrary.org/obo/MP_0001056 abnormal cranial nerve morphology any structural anomaly of the chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular http://purl.obolibrary.org/obo/MP_0001066 absent trigeminal nerve http://purl.obolibrary.org/obo/MP_0001065 abnormal trigeminal nerve morphology lack of the chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular http://purl.obolibrary.org/obo/MP_0001067 absent mandibular nerve http://purl.obolibrary.org/obo/MP_0001066 absent trigeminal nerve missing third division of the trigeminal nerve http://purl.obolibrary.org/obo/MP_0001068 abnormal mandibular nerve branching http://purl.obolibrary.org/obo/MP_0009800 abnormal mandibular nerve morphology malformed or misprojected axons of the mandibular nerve http://purl.obolibrary.org/obo/MP_0001069 absent trigeminal nerve connections to hindbrain http://purl.obolibrary.org/obo/MP_0001065 abnormal trigeminal nerve morphology missing axonal connection from the trigeminal ganglion to the pons and medulla oblongata http://purl.obolibrary.org/obo/MP_0001070 abnormal abducens nerve morphology http://purl.obolibrary.org/obo/MP_0001056 abnormal cranial nerve morphology any structural anomaly of the sixth cranial nerve, which originates in the abducens nucleus of the pons and sends motor fibers to the lateral rectus muscles of the eye http://purl.obolibrary.org/obo/MP_0001071 abnormal facial nerve morphology http://purl.obolibrary.org/obo/MP_0001056 abnormal cranial nerve morphology any structural anomaly of the sensory and motor nerve that supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue; principal branches are the superficial opthalmic, buccal, palatine and hyomandibular http://purl.obolibrary.org/obo/MP_0001072 abnormal vestibulocochlear nerve morphology http://purl.obolibrary.org/obo/MP_0001056 abnormal cranial nerve morphology any structural anomaly in the composite sensory nerve innervating the receptor cells of the membranous labyrinth; it consists of two major, anatomically and functionally distinct components, each of which have different central connections: the vestibular nerve and the cochlear nerve http://purl.obolibrary.org/obo/MP_0001073 abnormal glossopharyngeal nerve morphology http://purl.obolibrary.org/obo/MP_0001056 abnormal cranial nerve morphology any structural anomaly of the sensory and autonomic axons to the parotid gland, carotid body, posterior third of the tongue; the branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion http://purl.obolibrary.org/obo/MP_0001074 abnormal vagus nerve morphology http://purl.obolibrary.org/obo/MP_0001056 abnormal cranial nerve morphology any structural anomaly of the autonomic, sensory and motor axons of the tenth cranial nerve; it is primarily sensory but also has visceromotor components; it originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components, and also controls some motor functions such as speech; the sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis http://purl.obolibrary.org/obo/MP_0001075 abnormal accessory nerve morphology http://purl.obolibrary.org/obo/MP_0001056 abnormal cranial nerve morphology any structural anomaly of the eleventh cranial nerve, which normally originates from neurons in the medulla and in the cervical spinal cord http://purl.obolibrary.org/obo/MP_0001076 abnormal hypoglossal nerve morphology http://purl.obolibrary.org/obo/MP_0001056 abnormal cranial nerve morphology any structural anomaly of the motor nerve which innervates all the intrinsic and all but one of the extrinsic muscles of the tongue http://purl.obolibrary.org/obo/MP_0001077 abnormal spinal nerve morphology http://purl.obolibrary.org/obo/MP_0002752 abnormal somatic nervous system morphology any structural anomaly of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment http://purl.obolibrary.org/obo/MP_0001078 abnormal phrenic nerve morphology http://purl.obolibrary.org/obo/MP_0001077 abnormal spinal nerve morphology any structural anomaly of motor, sensory and sympathetic neuron axons that project to the diaphragm and other tissues http://purl.obolibrary.org/obo/MP_0001079 absent phrenic nerve http://purl.obolibrary.org/obo/MP_0001078 abnormal phrenic nerve morphology absence of the motor, sensory and sympathetic neuron axons that project to the diaphragm and other tissues http://purl.obolibrary.org/obo/MP_0001080 defasiculated phrenic nerve http://purl.obolibrary.org/obo/MP_0001078 abnormal phrenic nerve morphology misprojection or failure to bundle the motor, sensory and sympathetic neuron axons that project to the diaphragm and other tissues http://purl.obolibrary.org/obo/MP_0001081 abnormal cranial ganglia morphology http://purl.obolibrary.org/obo/MP_0002752 abnormal somatic nervous system morphology any structural anomaly of the groups of nerve cell bodies associated with the twelve cranial nerves http://purl.obolibrary.org/obo/MP_0001082 abnormal geniculate ganglion morphology http://purl.obolibrary.org/obo/MP_0001081 abnormal cranial ganglia morphology any structural anomaly of the group of sensory neuron cell bodies associated with the facial nerve (seventh cranial nerve) http://purl.obolibrary.org/obo/MP_0001083 small geniculate ganglion http://purl.obolibrary.org/obo/MP_0001082 abnormal geniculate ganglion morphology reduced size of the geniculate ganglion or decreased size of sensory neuron cell bodies associated with the facial nerve http://purl.obolibrary.org/obo/MP_0001084 abnormal petrosal ganglion morphology http://purl.obolibrary.org/obo/MP_0001096 abnormal glossopharyngeal ganglion morphology any structural anomaly of the larger, lower group of sensory neuron cell bodies associated with the glossopharyngeal nerve http://purl.obolibrary.org/obo/MP_0001085 small petrosal ganglion http://purl.obolibrary.org/obo/MP_0001084 abnormal petrosal ganglion morphology reduced size of the lower group of sensory neuron cell bodies associated with the glossopharyngeal nerve http://purl.obolibrary.org/obo/MP_0001086 absent petrosal ganglion http://purl.obolibrary.org/obo/MP_0001084 abnormal petrosal ganglion morphology absence of the lower group of sensory neuron cell bodies associated with the glossopharyngeal nerve http://purl.obolibrary.org/obo/MP_0001087 abnormal nodose ganglion morphology http://purl.obolibrary.org/obo/MP_0001100 abnormal vagus ganglion morphology any structural anomaly of the large group of sensory neuron cell bodies, anterior to the jugular vein, associated with the vagus nerve (tenth cranial nerve) http://purl.obolibrary.org/obo/MP_0001088 small nodose ganglion http://purl.obolibrary.org/obo/MP_0001087 abnormal nodose ganglion morphology reduced size of the large group of sensory neuron cell bodies, anterior to the jugular vein, associated with the vagus nerve (tenth cranial nerve) http://purl.obolibrary.org/obo/MP_0001089 absent nodose ganglion http://purl.obolibrary.org/obo/MP_0001087 abnormal nodose ganglion morphology absence of the large group of sensory neuron cell bodies, anterior to the jugular vein, associated with the vagus nerve (tenth cranial nerve) http://purl.obolibrary.org/obo/MP_0001092 abnormal trigeminal ganglion morphology http://purl.obolibrary.org/obo/MP_0001081 abnormal cranial ganglia morphology any structural anomaly of the group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve) http://purl.obolibrary.org/obo/MP_0001093 small trigeminal ganglion http://purl.obolibrary.org/obo/MP_0001092 abnormal trigeminal ganglion morphology reduced size of the trigeminal ganglion http://purl.obolibrary.org/obo/MP_0001094 trigeminal ganglion hypertrophy http://purl.obolibrary.org/obo/MP_0001095 enlarged trigeminal ganglion increased bulk size due to increased cell size of the trigeminal ganglion http://purl.obolibrary.org/obo/MP_0001095 enlarged trigeminal ganglion http://purl.obolibrary.org/obo/MP_0001092 abnormal trigeminal ganglion morphology increased size of the group of sensory neuron cell bodies associated with the trigeminal nerve http://purl.obolibrary.org/obo/MP_0001096 abnormal glossopharyngeal ganglion morphology http://purl.obolibrary.org/obo/MP_0001081 abnormal cranial ganglia morphology any structural anomaly of the two groups of sensory neuron cell bodies associated with the ninth cranial nerve http://purl.obolibrary.org/obo/MP_0001097 abnormal superior glossopharyngeal ganglion morphology http://purl.obolibrary.org/obo/MP_0001096 abnormal glossopharyngeal ganglion morphology any structural anomaly of the upper, smaller ganglion of the glossopharyngeal nerve located at the jugular foramen http://purl.obolibrary.org/obo/MP_0001098 small superior glossopharyngeal ganglion http://purl.obolibrary.org/obo/MP_0001097 abnormal superior glossopharyngeal ganglion morphology reduced size of the upper ganglion of the glossopharyngeal nerve located at the jugular foramen http://purl.obolibrary.org/obo/MP_0001100 abnormal vagus ganglion morphology http://purl.obolibrary.org/obo/MP_0001081 abnormal cranial ganglia morphology any structural anomaly of the group of sensory neuron cell bodies associated with the vagus nerve http://purl.obolibrary.org/obo/MP_0001101 abnormal superior vagus ganglion morphology http://purl.obolibrary.org/obo/MP_0001100 abnormal vagus ganglion morphology any structural anomaly of the upper ganglion of the vagus nerve located at the jugular foramen http://purl.obolibrary.org/obo/MP_0001102 small superior vagus ganglion http://purl.obolibrary.org/obo/MP_0001101 abnormal superior vagus ganglion morphology reduced size of the upper ganglion of the vagus nerve located at the jugular foramen http://purl.obolibrary.org/obo/MP_0001105 abnormal PNS glial cell morphology http://purl.obolibrary.org/obo/MP_0003634 abnormal glial cell morphology any structural anomaly of non-neuronal cells that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons http://purl.obolibrary.org/obo/MP_0001106 abnormal Schwann cell morphology http://purl.obolibrary.org/obo/MP_0001105 abnormal PNS glial cell morphology any structural anomaly of the cells which form the insulating myelin sheaths of peripheral axons http://purl.obolibrary.org/obo/MP_0001107 decreased Schwann cell number http://purl.obolibrary.org/obo/MP_0001106 abnormal Schwann cell morphology fewer than normal number of cells that sheath the axons of the peripheral nervous system http://purl.obolibrary.org/obo/MP_0001108 absent Schwann cells http://purl.obolibrary.org/obo/MP_0001107 decreased Schwann cell number missing cells that sheath the axons of the peripheral nervous system http://purl.obolibrary.org/obo/MP_0001109 absent Schwann cell precursors http://purl.obolibrary.org/obo/MP_0004075 decreased Schwann cell precursor number missing progenitors of cells that sheath the axons of the peripheral nervous system http://purl.obolibrary.org/obo/MP_0001116 small gonad http://purl.obolibrary.org/obo/MP_0002211 abnormal primary sex determination reduced size of the testis or the ovary http://purl.obolibrary.org/obo/MP_0001117 absent gametes http://purl.obolibrary.org/obo/MP_0004806 absent germ cells absence of mature reproductive cells, ovum or spermatozoon, capable of fusing with a cell of similar origin, but opposite sex to give a zygote http://purl.obolibrary.org/obo/MP_0001119 abnormal female reproductive system morphology http://purl.obolibrary.org/obo/MP_0002160 abnormal reproductive system morphology any structural anomaly of the organs associated with producing offspring in the gender that bears the offspring http://purl.obolibrary.org/obo/MP_0001120 abnormal uterus morphology http://purl.obolibrary.org/obo/MP_0009209 abnormal internal female genitalia morphology any structural anomaly of the female muscular organ of gestation in which the developing embryo or fetus is nourished until birth http://purl.obolibrary.org/obo/MP_0001121 uterus hypoplasia http://purl.obolibrary.org/obo/MP_0002637 small uterus underdevelopment or reduced size of the uterus, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0001123 dilated uterus http://purl.obolibrary.org/obo/MP_0001120 abnormal uterus morphology stretched or widened luminal space of the female muscular organ of gestation http://purl.obolibrary.org/obo/MP_0001124 abnormal gametes http://purl.obolibrary.org/obo/MP_0002208 abnormal germ cell morphology anomaly of any mature reproductive cell, ovum or spermatozoon, capable of fusing with a cell of similar origin, but opposite sex, to produce a zygote http://purl.obolibrary.org/obo/MP_0001125 abnormal oocyte morphology http://purl.obolibrary.org/obo/MP_0006361 abnormal female germ cell morphology any structural anomaly of the mature germ cells in the female http://purl.obolibrary.org/obo/MP_0001126 abnormal ovary morphology http://purl.obolibrary.org/obo/MP_0013324 abnormal female reproductive gland morphology any structural anomaly of the female reproductive gland containing the germ cells http://purl.obolibrary.org/obo/MP_0001127 small ovary http://purl.obolibrary.org/obo/MP_0004853 abnormal ovary size reduced size of the female reproductive gland containing the germ cells http://purl.obolibrary.org/obo/MP_0001128 ovary hyperplasia http://purl.obolibrary.org/obo/MP_0004832 enlarged ovary overdevelopment or increased size, usually due an increased number of cells in the ovary http://purl.obolibrary.org/obo/MP_0001129 impaired ovarian folliculogenesis http://purl.obolibrary.org/obo/MP_0001130 abnormal ovarian folliculogenesis a block in the formation of the spherical ovum in the ovary http://purl.obolibrary.org/obo/MP_0001130 abnormal ovarian folliculogenesis http://purl.obolibrary.org/obo/MP_0001131 abnormal ovarian follicle morphology atypical formation or failure to form the spherical ovum in the ovary http://purl.obolibrary.org/obo/MP_0001131 abnormal ovarian follicle morphology http://purl.obolibrary.org/obo/MP_0001126 abnormal ovary morphology any structural anomaly of the sac-like structure in the ovary which surrounds an ovum http://purl.obolibrary.org/obo/MP_0001132 absent mature ovarian follicles http://purl.obolibrary.org/obo/MP_0002682 decreased mature ovarian follicle number absence of ovarian follicles that are ready for ovulation and present a blanched spot (the follicular stigma) where the graafian follicle is about to rupture on the surface of the ovary; a first maturation (meiotic) division of the primary oocyte usually occurs just prior to rupture of the follicle http://purl.obolibrary.org/obo/MP_0001133 impaired luteal cell differentiation http://purl.obolibrary.org/obo/MP_0005076 abnormal cell differentiation abnormal development of the cells of the corpus luteum of the ovary http://purl.obolibrary.org/obo/MP_0001134 absent corpus luteum http://purl.obolibrary.org/obo/MP_0002679 abnormal corpus luteum morphology absence of the yellow endocrine body formed in the ovary after follicle rupture http://purl.obolibrary.org/obo/MP_0001135 abnormal uterine cervix morphology http://purl.obolibrary.org/obo/MP_0001120 abnormal uterus morphology any structural anomaly of the lower opening of the uterus to the vagina http://purl.obolibrary.org/obo/MP_0001136 dilated uterine cervix http://purl.obolibrary.org/obo/MP_0001135 abnormal uterine cervix morphology stretched or widened aperture of the lower opening of the uterus to the vagina http://purl.obolibrary.org/obo/MP_0001137 abnormal uterine cervix epithelium morphology http://purl.obolibrary.org/obo/MP_0001135 abnormal uterine cervix morphology any structural anomaly of the epithelial layer of the cervix http://purl.obolibrary.org/obo/MP_0001138 abnormal uterine cervix squamous epithelium morphology http://purl.obolibrary.org/obo/MP_0001137 abnormal uterine cervix epithelium morphology any structural anomaly of the scaly epithelial layer of the cervix http://purl.obolibrary.org/obo/MP_0001139 abnormal vagina morphology http://purl.obolibrary.org/obo/MP_0009209 abnormal internal female genitalia morphology any structural anomaly of the part of the genital canal in the female that extends between the cervix of the uterus and the vestibule; it is an organ of copulation that receives the penis during sexual intercourse http://purl.obolibrary.org/obo/MP_0001140 abnormal vagina epithelium morphology http://purl.obolibrary.org/obo/MP_0001139 abnormal vagina morphology any structural anomaly of the epithelial layer of the vagina http://purl.obolibrary.org/obo/MP_0001141 thickened vaginal epithelium http://purl.obolibrary.org/obo/MP_0001140 abnormal vagina epithelium morphology increased depth of the vaginal epithelial layer http://purl.obolibrary.org/obo/MP_0001142 abnormal vagina orifice morphology http://purl.obolibrary.org/obo/MP_0001139 abnormal vagina morphology any structural anomaly of the median slit located inferior and posterior to the external urethral orifice in the female; the exit for menstrual flow and birth and the entrance for the penis during sexual intercourse; the size and appearance of the vaginal orifice varies inversely with that of the hymen (G. membrane), a thin fold of mucous membrane that surrounds the vaginal orifice http://purl.obolibrary.org/obo/MP_0001143 constricted vagina orifice http://purl.obolibrary.org/obo/MP_0001142 abnormal vagina orifice morphology shrunken, narrowed external median slit located inferior and posterior to the external urethral orifice in the female http://purl.obolibrary.org/obo/MP_0001144 vagina atresia http://purl.obolibrary.org/obo/MP_0001142 abnormal vagina orifice morphology imperforation or occlusion of the vagina, or adhesion of the walls of the vagina http://purl.obolibrary.org/obo/MP_0001145 abnormal male reproductive system morphology http://purl.obolibrary.org/obo/MP_0002160 abnormal reproductive system morphology any structural anomaly of the organs associated with producing offspring in the gender that produces spermatozoa http://purl.obolibrary.org/obo/MP_0001146 abnormal testis morphology http://purl.obolibrary.org/obo/MP_0013325 abnormal male reproductive gland morphology any structural anomaly of the male reproductive glands http://purl.obolibrary.org/obo/MP_0001147 small testis http://purl.obolibrary.org/obo/MP_0004849 abnormal testis size reduced size of the male reproductive glands http://purl.obolibrary.org/obo/MP_0001148 enlarged testis http://purl.obolibrary.org/obo/MP_0004849 abnormal testis size increased size of the male reproductive glands http://purl.obolibrary.org/obo/MP_0001149 testicular hyperplasia http://purl.obolibrary.org/obo/MP_0001148 enlarged testis overdevelopment or increased size, usually due an increased number of cells in the testes http://purl.obolibrary.org/obo/MP_0001150 enlarged scrotum http://purl.obolibrary.org/obo/MP_0002669 abnormal scrotum morphology increased size of the external sac of skin that encloses the testes http://purl.obolibrary.org/obo/MP_0001151 enlarged foreskin http://purl.obolibrary.org/obo/MP_0003553 abnormal foreskin morphology increased size of the loose fold of skin that covers the penis http://purl.obolibrary.org/obo/MP_0001152 Leydig cell hyperplasia http://purl.obolibrary.org/obo/MP_0002786 abnormal Leydig cell morphology increased number of interstitial cells of the seminiferous tubules that secrete testosterone http://purl.obolibrary.org/obo/MP_0001153 small seminiferous tubules http://purl.obolibrary.org/obo/MP_0006307 abnormal seminiferous tubule size reduced diameter of the tubules in the testes where spermatogenesis occurs http://purl.obolibrary.org/obo/MP_0001154 seminiferous tubule degeneration http://purl.obolibrary.org/obo/MP_0002216 abnormal seminiferous tubule morphology a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs http://purl.obolibrary.org/obo/MP_0001155 arrest of spermatogenesis http://purl.obolibrary.org/obo/MP_0001156 abnormal spermatogenesis block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa http://purl.obolibrary.org/obo/MP_0001156 abnormal spermatogenesis http://purl.obolibrary.org/obo/MP_0001929 abnormal gametogenesis incomplete maturation or aberrant formation of the male gametes http://purl.obolibrary.org/obo/MP_0001157 small seminal vesicle http://purl.obolibrary.org/obo/MP_0004907 abnormal seminal vesicle size reduced size of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens http://purl.obolibrary.org/obo/MP_0001158 abnormal prostate gland morphology http://purl.obolibrary.org/obo/MP_0013330 abnormal male accessory sex gland morphology any structural anomaly of the gland in males that secretes part of the seminiferous fluid http://purl.obolibrary.org/obo/MP_0001159 absent prostate gland http://purl.obolibrary.org/obo/MP_0001158 abnormal prostate gland morphology missing gland in males that secretes part of the seminiferous fluid http://purl.obolibrary.org/obo/MP_0001163 abnormal prostate gland anterior lobe morphology http://purl.obolibrary.org/obo/MP_0001158 abnormal prostate gland morphology any structural anomaly of the rodent prostate lobe that appears as a thin tubular structure, attached to the lesser curvature of the paired seminal vesicles http://purl.obolibrary.org/obo/MP_0001167 prostate gland epithelial hyperplasia http://purl.obolibrary.org/obo/MP_0001168 abnormal prostate gland epithelium morphology epithelium is multi-layered instead of columnar and has increased cell number http://purl.obolibrary.org/obo/MP_0001168 abnormal prostate gland epithelium morphology http://purl.obolibrary.org/obo/MP_0001158 abnormal prostate gland morphology any structural anomaly of the prostate epithelium http://purl.obolibrary.org/obo/MP_0001169 abnormal bulbourethral gland morphology http://purl.obolibrary.org/obo/MP_0013330 abnormal male accessory sex gland morphology any structural anomaly of any of the small paired racemose (compound tubulo-alveolar) glands below the apex of the prostate in males, located posterolateral to the membranous portion of the urethra at the base of the penis, between the two layers of the fascia of the urogenital diaphragm, in the deep perineal pouch, and enclosed by transverse fibers of the sphincter urethrae membranaceae muscle; they secrete a clear fluid known as pre-ejaculate (Cowper's fluid), and are homologous to the greater vestibular (Bartholin's) glands in the female http://purl.obolibrary.org/obo/MP_0001170 bulbourethral gland hyperplasia http://purl.obolibrary.org/obo/MP_0001169 abnormal bulbourethral gland morphology overdevelopment or increased size, usually due an increased number of cells in the bulbourethral gland http://purl.obolibrary.org/obo/MP_0001175 abnormal lung morphology http://purl.obolibrary.org/obo/MP_0002132 abnormal respiratory system morphology any structural anomaly of the paired lobed visceral organs of respiration in the pulmonary cavity of the thorax where aeration of the blood normally occurs http://purl.obolibrary.org/obo/MP_0001176 abnormal lung development http://purl.obolibrary.org/obo/MP_0003115 abnormal respiratory system development anomaly in the process of formation of the paired lobed visceral organs of respiration in the pulmonary cavity of the thorax where aeration of the blood normally occurs http://purl.obolibrary.org/obo/MP_0001177 atelectasis http://purl.obolibrary.org/obo/MP_0002133 abnormal respiratory system physiology decrease or absent air in the entire or part of a lung, with resulting loss of lung volume, due to trauma, blockage or congenital defect http://purl.obolibrary.org/obo/MP_0001178 pulmonary hypoplasia http://purl.obolibrary.org/obo/MP_0003641 small lung underdevelopment or reduced size of the respiratory organ due to reduced cell number in all or part of the organ http://purl.obolibrary.org/obo/MP_0001179 thick pulmonary interalveolar septum http://purl.obolibrary.org/obo/MP_0010900 abnormal pulmonary interalveolar septum morphology increased width of the tissue intervening between two adjacent pulmonary alveoli, which consists of the basement membranes of alveolar-lining epithelium (mostly type I pneumocytes) and capillary endothelium http://purl.obolibrary.org/obo/MP_0001181 absent lungs http://purl.obolibrary.org/obo/MP_0001175 abnormal lung morphology absence of the paired lobed visceral organs of respiration in the pulmonary cavity of the thorax where aeration of the blood normally occurs http://purl.obolibrary.org/obo/MP_0001182 lung hemorrhage http://purl.obolibrary.org/obo/MP_0002295 abnormal pulmonary circulation bleeding within the paired lobed visceral organs of respiration in the pulmonary cavity of the thorax where aeration of the blood normally occurs http://purl.obolibrary.org/obo/MP_0001183 overexpanded pulmonary alveoli http://purl.obolibrary.org/obo/MP_0002270 abnormal pulmonary alveolus morphology expanded volume of the saclike terminal dilation of the respiratory bronchioles, alveolar ducts and alveolar sacs across which gas exchance occurs between alveolar air and the pulmonary capillaries http://purl.obolibrary.org/obo/MP_0001184 absent pulmonary alveoli http://purl.obolibrary.org/obo/MP_0002270 abnormal pulmonary alveolus morphology absence of the saclike terminal dilation of the respiratory bronchioles, alveolar ducts and alveolar sacs across which gas exchance occurs between alveolar air and the pulmonary capillaries http://purl.obolibrary.org/obo/MP_0001188 hyperpigmentation http://purl.obolibrary.org/obo/MP_0001186 pigmentation phenotype excess of pigment in any or all tissues or a part of a tissue http://purl.obolibrary.org/obo/MP_0001189 absent skin pigmentation http://purl.obolibrary.org/obo/MP_0002095 abnormal skin pigmentation lack of pigmentation of the skin http://purl.obolibrary.org/obo/MP_0001190 reddish skin http://purl.obolibrary.org/obo/MP_0009931 abnormal skin appearance skin has a more intense ruddy appearance than normal, often due to capillary congestion http://purl.obolibrary.org/obo/MP_0001191 abnormal skin condition http://purl.obolibrary.org/obo/MP_0002060 abnormal skin morphology any anomaly in the state or quality of the skin http://purl.obolibrary.org/obo/MP_0001192 scaly skin http://purl.obolibrary.org/obo/MP_0009931 abnormal skin appearance skin covered with shedding scales http://purl.obolibrary.org/obo/MP_0001193 psoriasis http://purl.obolibrary.org/obo/MP_0001191 abnormal skin condition chronic skin lesions characterized by inflammation and silvery-scaly patches http://purl.obolibrary.org/obo/MP_0001194 dermatitis http://purl.obolibrary.org/obo/MP_0004947 skin inflammation inflammation of the skin (redness and itching) caused by an allergic reaction or contact with an irritant http://purl.obolibrary.org/obo/MP_0001195 flaky skin http://purl.obolibrary.org/obo/MP_0009931 abnormal skin appearance shedding flakes on the skin http://purl.obolibrary.org/obo/MP_0001196 shiny skin http://purl.obolibrary.org/obo/MP_0009931 abnormal skin appearance skin with a glossy or glistening appearance http://purl.obolibrary.org/obo/MP_0001197 oily skin http://purl.obolibrary.org/obo/MP_0001196 shiny skin skin secreting an unusually high amount of oil, resulting in a glossy, shiny appearance http://purl.obolibrary.org/obo/MP_0001198 tight skin http://purl.obolibrary.org/obo/MP_0009931 abnormal skin appearance skin has a taut, stretched appearance http://purl.obolibrary.org/obo/MP_0001199 thin skin http://purl.obolibrary.org/obo/MP_0001191 abnormal skin condition reduced thickness of the outer protective layer of the body http://purl.obolibrary.org/obo/MP_0001200 thick skin http://purl.obolibrary.org/obo/MP_0001191 abnormal skin condition greater thickness of the outer protective layer of the body http://purl.obolibrary.org/obo/MP_0001201 translucent skin http://purl.obolibrary.org/obo/MP_0009931 abnormal skin appearance skin that is more transparent to light than normal http://purl.obolibrary.org/obo/MP_0001202 skin photosensitivity http://purl.obolibrary.org/obo/MP_0005501 abnormal skin physiology abnormally heightened reactivity of the skin to sunlight http://purl.obolibrary.org/obo/MP_0001203 increased sensitivity to skin irradiation http://purl.obolibrary.org/obo/MP_0005501 abnormal skin physiology increased incidence of aberrant or damaged cells due to irradiation induced genotoxic damage http://purl.obolibrary.org/obo/MP_0001204 decreased sensitivity to skin irradiation http://purl.obolibrary.org/obo/MP_0005501 abnormal skin physiology decreased incidence of aberrant or damaged cells due to irradiation induced genotoxic damage http://purl.obolibrary.org/obo/MP_0001208 blistering http://purl.obolibrary.org/obo/MP_0009931 abnormal skin appearance accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis http://purl.obolibrary.org/obo/MP_0001209 spontaneous skin ulceration http://purl.obolibrary.org/obo/MP_0001212 skin lesions unpredictable appearance of skin lesions, usually with inflammation http://purl.obolibrary.org/obo/MP_0001210 skin ridges http://purl.obolibrary.org/obo/MP_0009931 abnormal skin appearance long raised strips of skin, usually aligned to the proximal-distal axis http://purl.obolibrary.org/obo/MP_0001211 wrinkled skin http://purl.obolibrary.org/obo/MP_0009931 abnormal skin appearance irregular folds and/or indentations on the skin http://purl.obolibrary.org/obo/MP_0001212 skin lesions http://purl.obolibrary.org/obo/MP_0009931 abnormal skin appearance focal pathological and/or inflammatory changes characterized by alteration in the size, shape and organization of the cellular components of the skin http://purl.obolibrary.org/obo/MP_0001213 abnormal skin cell number http://purl.obolibrary.org/obo/MP_0002060 abnormal skin morphology greater than or fewer than the expected numbers of cells in the cutis http://purl.obolibrary.org/obo/MP_0001214 skin hyperplasia http://purl.obolibrary.org/obo/MP_0001213 abnormal skin cell number overdevelopment or increased size, usually due an increased number of cells in the skin; usually results in thick skin http://purl.obolibrary.org/obo/MP_0001215 skin hypoplasia http://purl.obolibrary.org/obo/MP_0001213 abnormal skin cell number underdevelopment of the cutis, usually due to a deficiency in the number of cells http://purl.obolibrary.org/obo/MP_0001216 abnormal epidermal layer morphology http://purl.obolibrary.org/obo/MP_0002060 abnormal skin morphology any structural anomaly of the superficial epithelial portion of the skin http://purl.obolibrary.org/obo/MP_0001217 absent epidermis http://purl.obolibrary.org/obo/MP_0001216 abnormal epidermal layer morphology missing the epidermal cell layer in the skin http://purl.obolibrary.org/obo/MP_0001218 thin epidermis http://purl.obolibrary.org/obo/MP_0001216 abnormal epidermal layer morphology reduced thickness of the superficial epithelial portion of the skin http://purl.obolibrary.org/obo/MP_0001219 thick epidermis http://purl.obolibrary.org/obo/MP_0001216 abnormal epidermal layer morphology increase in the width of the epidermal cell layer in the skin http://purl.obolibrary.org/obo/MP_0001220 epidermal necrosis http://purl.obolibrary.org/obo/MP_0001216 abnormal epidermal layer morphology morphological changes resulting from pathological death of the epidermal layer of skin; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0001221 epidermal atrophy http://purl.obolibrary.org/obo/MP_0001216 abnormal epidermal layer morphology acquired diminution of the size of epidermal layer of the skin, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0001222 epidermal hyperplasia http://purl.obolibrary.org/obo/MP_0001216 abnormal epidermal layer morphology overdevelopment or increased size, usually due an increased number of cells in the epidermis http://purl.obolibrary.org/obo/MP_0001224 abnormal keratinocyte apoptosis http://purl.obolibrary.org/obo/MP_0003453 abnormal keratinocyte physiology aberrant programmed cell death or anomaly in the number of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum http://purl.obolibrary.org/obo/MP_0001230 epidermal desquamation http://purl.obolibrary.org/obo/MP_0001216 abnormal epidermal layer morphology shedding of the cuticle of the epidermis in scales or shreds http://purl.obolibrary.org/obo/MP_0001231 abnormal epidermis stratum basale morphology http://purl.obolibrary.org/obo/MP_0001216 abnormal epidermal layer morphology any structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells http://purl.obolibrary.org/obo/MP_0001232 absent epidermis stratum basale http://purl.obolibrary.org/obo/MP_0001231 abnormal epidermis stratum basale morphology absence of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells http://purl.obolibrary.org/obo/MP_0001233 abnormal epidermis suprabasal layer morphology http://purl.obolibrary.org/obo/MP_0001216 abnormal epidermal layer morphology any structural anomaly of the suprabasal layer of the epidermis http://purl.obolibrary.org/obo/MP_0001234 absent suprabasal layer http://purl.obolibrary.org/obo/MP_0001233 abnormal epidermis suprabasal layer morphology absence of the suprabasal layer of the skin http://purl.obolibrary.org/obo/MP_0001235 disorganized suprabasal layer http://purl.obolibrary.org/obo/MP_0001233 abnormal epidermis suprabasal layer morphology derangement of the pattern of the suprabasal layer of the skin http://purl.obolibrary.org/obo/MP_0001236 abnormal epidermis stratum spinosum morphology http://purl.obolibrary.org/obo/MP_0001216 abnormal epidermal layer morphology any structural anomaly of the layer of polyhedral cells in the epidermis; shrinkage and adhesion of these cells gives a spiny or prickly appearance http://purl.obolibrary.org/obo/MP_0001237 enlarged spinous cells http://purl.obolibrary.org/obo/MP_0002656 abnormal keratinocyte differentiation increased size of the immature keratinocytes of the spinous layer of the epidermis http://purl.obolibrary.org/obo/MP_0001238 thin epidermis stratum spinosum http://purl.obolibrary.org/obo/MP_0001236 abnormal epidermis stratum spinosum morphology reduced thickness of the stratum spinosum; the polyhedral cell layer http://purl.obolibrary.org/obo/MP_0001239 abnormal epidermis stratum granulosum morphology http://purl.obolibrary.org/obo/MP_0001216 abnormal epidermal layer morphology any structural anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis http://purl.obolibrary.org/obo/MP_0001240 abnormal epidermis stratum corneum morphology http://purl.obolibrary.org/obo/MP_0001216 abnormal epidermal layer morphology any structural anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells http://purl.obolibrary.org/obo/MP_0001241 absent epidermis stratum corneum http://purl.obolibrary.org/obo/MP_0001240 abnormal epidermis stratum corneum morphology absence of the outer layer of the epidermis, composed of several layers of keratinized non-nucleated cells http://purl.obolibrary.org/obo/MP_0001242 hyperkeratosis http://purl.obolibrary.org/obo/MP_0001240 abnormal epidermis stratum corneum morphology thickening of the horny layer of the epidermis http://purl.obolibrary.org/obo/MP_0001243 abnormal dermal layer morphology http://purl.obolibrary.org/obo/MP_0002060 abnormal skin morphology any structural anomaly or atypical condition of the dermal layer of the skin http://purl.obolibrary.org/obo/MP_0001244 thin dermal layer http://purl.obolibrary.org/obo/MP_0001243 abnormal dermal layer morphology reduced thickness of the dermis http://purl.obolibrary.org/obo/MP_0001245 thick dermal layer http://purl.obolibrary.org/obo/MP_0001243 abnormal dermal layer morphology increased depth of the dermis http://purl.obolibrary.org/obo/MP_0001246 mixed cellular infiltration to dermis http://purl.obolibrary.org/obo/MP_0001243 abnormal dermal layer morphology gradual accumulation of mixed cell types in the dermis that are not normally found there http://purl.obolibrary.org/obo/MP_0001247 dermal cysts http://purl.obolibrary.org/obo/MP_0001243 abnormal dermal layer morphology abnormal membranous sacs appearing in the dermis http://purl.obolibrary.org/obo/MP_0001251 dermis papillary layer hypercellularity http://purl.obolibrary.org/obo/MP_0009545 abnormal dermis papillary layer morphology increased cell density of the superficial layer http://purl.obolibrary.org/obo/MP_0001253 abnormal body height http://purl.obolibrary.org/obo/MP_0003956 abnormal body size any anomaly in the shoulder to floor distance compared to controls http://purl.obolibrary.org/obo/MP_0001254 increased body height http://purl.obolibrary.org/obo/MP_0001264 increased body size increased shoulder to floor distance compared to controls http://purl.obolibrary.org/obo/MP_0001255 decreased body height http://purl.obolibrary.org/obo/MP_0001265 decreased body size decreased shoulder to floor distance compared to controls http://purl.obolibrary.org/obo/MP_0001256 abnormal body length http://purl.obolibrary.org/obo/MP_0003956 abnormal body size any anomaly in the measure of the head and trunk (head, thorax and abdomen) in the rostral-caudal direction http://purl.obolibrary.org/obo/MP_0001257 increased body length http://purl.obolibrary.org/obo/MP_0001264 increased body size increased measure of the head and trunk (head, thorax and abdomen) in the rostral-caudal direction http://purl.obolibrary.org/obo/MP_0001258 decreased body length http://purl.obolibrary.org/obo/MP_0001265 decreased body size decreased measure of the head and trunk (head, thorax and abdomen) in the rostral-caudal direction http://purl.obolibrary.org/obo/MP_0001259 abnormal body weight http://purl.obolibrary.org/obo/MP_0003956 abnormal body size anomaly in average weight compared to controls http://purl.obolibrary.org/obo/MP_0001260 increased body weight http://purl.obolibrary.org/obo/MP_0012323 increased total tissue mass greater than normal average weight http://purl.obolibrary.org/obo/MP_0001262 decreased body weight http://purl.obolibrary.org/obo/MP_0012322 decreased total tissue mass lower than normal average weight http://purl.obolibrary.org/obo/MP_0001263 weight loss http://purl.obolibrary.org/obo/MP_0001262 decreased body weight progressive reduction of body weight below normal average for age http://purl.obolibrary.org/obo/MP_0001264 increased body size http://purl.obolibrary.org/obo/MP_0003956 abnormal body size larger than average body weight, height and/or length of an organism compared to controls http://purl.obolibrary.org/obo/MP_0001265 decreased body size http://purl.obolibrary.org/obo/MP_0003956 abnormal body size smaller than average body weight, height and/or length of an organism compared to controls http://purl.obolibrary.org/obo/MP_0001267 enlarged chest http://purl.obolibrary.org/obo/MP_0004134 abnormal chest morphology wider diameter, or distended chest cavity http://purl.obolibrary.org/obo/MP_0001268 barrel chest http://purl.obolibrary.org/obo/MP_0001267 enlarged chest distended circumference of the thoracic and abdominal areas http://purl.obolibrary.org/obo/MP_0001270 distended abdomen http://purl.obolibrary.org/obo/MP_0005378 growth/size/body phenotype abdomen appears curved outward or swollen http://purl.obolibrary.org/obo/MP_0001272 increased metastatic potential http://purl.obolibrary.org/obo/MP_0000858 altered metastatic potential greater likelihood of a tumor cell spreading from the site of the initial tumor formation and forming a secondary tumor at another site not directly connected with it http://purl.obolibrary.org/obo/MP_0001273 decreased metastatic potential http://purl.obolibrary.org/obo/MP_0000858 altered metastatic potential reduced likelihood of a tumor cell spreading from the site of the initial tumor formation and forming a secondary tumor at another site not directly connected with it http://purl.obolibrary.org/obo/MP_0001274 curly vibrissae http://purl.obolibrary.org/obo/MP_0002098 abnormal vibrissa morphology coiled or spiral shape of the stiff hairs that project from the face around the nose of most mammals, and which act as touch receptors http://purl.obolibrary.org/obo/MP_0001277 tangled vibrissae http://purl.obolibrary.org/obo/MP_0002098 abnormal vibrissa morphology snarled or intertwined stiff hairs that project from the face around the nose of most mammals, and which act as touch receptors http://purl.obolibrary.org/obo/MP_0001278 kinked vibrissae http://purl.obolibrary.org/obo/MP_0002098 abnormal vibrissa morphology sharp bends in the stiff hairs that project from the face around the nose of most mammals, and which act as touch receptors http://purl.obolibrary.org/obo/MP_0001279 wavy vibrissae http://purl.obolibrary.org/obo/MP_0002098 abnormal vibrissa morphology undulations or a sinusoidal shape of the stiff hairs that project from the face around the nose of most mammals, and which act as touch receptors http://purl.obolibrary.org/obo/MP_0001280 loss of vibrissae http://purl.obolibrary.org/obo/MP_0002098 abnormal vibrissa morphology inability to retain the stiff hairs that project from the face around the nose of most mammals, and which act as touch receptors http://purl.obolibrary.org/obo/MP_0001281 increased vibrissae length http://purl.obolibrary.org/obo/MP_0002098 abnormal vibrissa morphology longer average length of the stiff hairs that project from the face around the nose of most mammals, and which act as touch receptors http://purl.obolibrary.org/obo/MP_0001282 short vibrissae http://purl.obolibrary.org/obo/MP_0002098 abnormal vibrissa morphology decreased length of the stiff hairs projecting from the face around the nose of most mammals which act as touch receptors http://purl.obolibrary.org/obo/MP_0001283 sparse vibrissae http://purl.obolibrary.org/obo/MP_0002098 abnormal vibrissa morphology few and widely spaced stiff hairs that project from the face around the nose of most mammals, and which act as touch receptors http://purl.obolibrary.org/obo/MP_0001284 absent vibrissae http://purl.obolibrary.org/obo/MP_0002098 abnormal vibrissa morphology absence of the stiff hairs that project from the face around the nose of most mammals, and which act as touch receptors http://purl.obolibrary.org/obo/MP_0001286 abnormal eye development http://purl.obolibrary.org/obo/MP_0002092 abnormal eye morphology malformation or arrest of differentiation of the visual organ http://purl.obolibrary.org/obo/MP_0001288 abnormal lens induction http://purl.obolibrary.org/obo/MP_0005545 abnormal lens development any anomaly in the signaling at short range between the head ectoderm and the optic vesicle that results in the head ectoderm forming a lens http://purl.obolibrary.org/obo/MP_0001289 persistence of hyaloid vascular system http://purl.obolibrary.org/obo/MP_0002699 abnormal vitreous body morphology failure of the degeneration of the transient vascular system of the eye during development, that normally nourishes the retina, immature lens and primary vitreous of the developing eye http://purl.obolibrary.org/obo/MP_0001290 delayed eyelid opening http://purl.obolibrary.org/obo/MP_0004874 abnormal timing of postnatal eyelid opening late average time for the first postnatal eye opening http://purl.obolibrary.org/obo/MP_0001292 abnormal lens vesicle development http://purl.obolibrary.org/obo/MP_0001288 abnormal lens induction malformation or abnormal patterning of the ectodermal invagination that forms opposite the optic cup in the primordium of the lens of the eye http://purl.obolibrary.org/obo/MP_0001293 anophthalmia http://purl.obolibrary.org/obo/MP_0002092 abnormal eye morphology absence of the globe and ocular tissue from the orbit, with or without the presence of ocular adnexa (eyelids, conjunctiva, and lacrimal apparatus); remnants of the globe sometimes appear in ectopic locations http://purl.obolibrary.org/obo/MP_0001296 macrophthalmia http://purl.obolibrary.org/obo/MP_0002697 abnormal eye size increased average size of the eyes http://purl.obolibrary.org/obo/MP_0001297 microphthalmia http://purl.obolibrary.org/obo/MP_0002697 abnormal eye size reduced average size of the eyes; generally refers to a congenital defect http://purl.obolibrary.org/obo/MP_0001299 abnormal eye distance/ position http://purl.obolibrary.org/obo/MP_0002092 abnormal eye morphology abnormal placement of the eyes in relation to each other or in relation to other craniofacial structures http://purl.obolibrary.org/obo/MP_0001300 ocular hypertelorism http://purl.obolibrary.org/obo/MP_0001299 abnormal eye distance/ position increased distance between the eyes http://purl.obolibrary.org/obo/MP_0001302 eyelids open at birth http://purl.obolibrary.org/obo/MP_0001340 abnormal eyelid morphology open eyes instead of closed at perinatal stage; failure of the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye to fuse completely together during development and an individual is born with the eye(s) uncovered leading to degrees of injury and blindness http://purl.obolibrary.org/obo/MP_0001303 abnormal lens morphology http://purl.obolibrary.org/obo/MP_0005193 abnormal anterior eye segment morphology any structural anomaly of the transparent structure of the eye responsible for focusing light rays http://purl.obolibrary.org/obo/MP_0001304 cataracts http://purl.obolibrary.org/obo/MP_0001303 abnormal lens morphology complete or partial opacity of the lens http://purl.obolibrary.org/obo/MP_0001305 enlarged lens http://purl.obolibrary.org/obo/MP_0001303 abnormal lens morphology increased size of the transparent structure of the eye responsible for focusing light rays http://purl.obolibrary.org/obo/MP_0001306 small lens http://purl.obolibrary.org/obo/MP_0001303 abnormal lens morphology reduced size of the transparent structure of the eye responsible for focusing light rays http://purl.obolibrary.org/obo/MP_0001307 fused cornea and lens http://purl.obolibrary.org/obo/MP_0005545 abnormal lens development condition in which the transparent anterior portion of the fibrous coat of the eye is joined to the transparent biconvex cellular refractive structure lying between the iris and vitreous humor of the eye http://purl.obolibrary.org/obo/MP_0001308 abnormal lens polarity http://purl.obolibrary.org/obo/MP_0001303 abnormal lens morphology failure of normal orientation of the lens during development http://purl.obolibrary.org/obo/MP_0001309 hydropic eye lens fibers http://purl.obolibrary.org/obo/MP_0002840 abnormal lens fiber morphology swollen cortical fibers of the eye lens http://purl.obolibrary.org/obo/MP_0001310 abnormal conjunctiva morphology http://purl.obolibrary.org/obo/MP_0005193 abnormal anterior eye segment morphology any structural anomaly of the mucous membrane that lines the inner surface of the eyelids and the front of the eyeball http://purl.obolibrary.org/obo/MP_0001312 abnormal cornea morphology http://purl.obolibrary.org/obo/MP_0005193 abnormal anterior eye segment morphology any structural anomaly of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure http://purl.obolibrary.org/obo/MP_0001313 increased incidence of corneal inflammation http://purl.obolibrary.org/obo/MP_0001851 eye inflammation greater than average occurrence and/or persistence of the local accumulation of fluid, plasma proteins, and leukocytes in the cornea http://purl.obolibrary.org/obo/MP_0001314 corneal opacity http://purl.obolibrary.org/obo/MP_0001312 abnormal cornea morphology complete or partial clouding of the cornea http://purl.obolibrary.org/obo/MP_0001316 corneal scarring http://purl.obolibrary.org/obo/MP_0001312 abnormal cornea morphology appearance of fibrous tissue on the cornea after healing in response to injury http://purl.obolibrary.org/obo/MP_0001317 abnormal pupil morphology http://purl.obolibrary.org/obo/MP_0001322 abnormal iris morphology any structural anomaly of the central circular aperture of the iris through which light rays enter the eye http://purl.obolibrary.org/obo/MP_0001318 pupil opacity http://purl.obolibrary.org/obo/MP_0001317 abnormal pupil morphology milky or cloudy appearance of the central circular aperture of the iris through which light rays normally enter the eye http://purl.obolibrary.org/obo/MP_0001319 irregularly shaped pupil http://purl.obolibrary.org/obo/MP_0001317 abnormal pupil morphology shape defects in the aperture of the iris through which light rays enter the eye, usually circular http://purl.obolibrary.org/obo/MP_0001320 small pupils http://purl.obolibrary.org/obo/MP_0001317 abnormal pupil morphology smaller than normal size of the central circular aperture of the iris through which light rays enter the eye http://purl.obolibrary.org/obo/MP_0001322 abnormal iris morphology http://purl.obolibrary.org/obo/MP_0005194 abnormal anterior uvea morphology any structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye http://purl.obolibrary.org/obo/MP_0001324 abnormal eye pigmentation http://purl.obolibrary.org/obo/MP_0009389 abnormal extracutaneous pigmentation change in the normal pigmentation of the eye to another color, or lack of color http://purl.obolibrary.org/obo/MP_0001325 abnormal retina morphology http://purl.obolibrary.org/obo/MP_0002864 abnormal ocular fundus morphology any structural anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors http://purl.obolibrary.org/obo/MP_0001326 retinal degeneration http://purl.obolibrary.org/obo/MP_0001325 abnormal retina morphology retrogressive pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function http://purl.obolibrary.org/obo/MP_0001327 decreased retinal photoreceptor cell number http://purl.obolibrary.org/obo/MP_0001004 abnormal retinal photoreceptor morphology fewer than the expected number of rods and/or cones http://purl.obolibrary.org/obo/MP_0001328 disorganized retinal layers http://purl.obolibrary.org/obo/MP_0003727 abnormal retinal layer morphology derangement of the pattern of the sheets of cells comprising the optic part of the retina http://purl.obolibrary.org/obo/MP_0001329 retina hyperplasia http://purl.obolibrary.org/obo/MP_0001325 abnormal retina morphology overdevelopment or increased size, usually due an increased number of cells in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors http://purl.obolibrary.org/obo/MP_0001330 abnormal optic nerve morphology http://purl.obolibrary.org/obo/MP_0005195 abnormal posterior eye segment morphology any structural anomaly of the second cranial nerve which is responsible for conveying visual information from the retina to the brain; it extends from the retina to the optic chiasma where part of its fibers become the optic tract and cross to the opposite side and pass to the geniculate bodies http://purl.obolibrary.org/obo/MP_0001332 abnormal optic nerve innervation http://purl.obolibrary.org/obo/MP_0001330 abnormal optic nerve morphology misprojection or aberrant target finding of the second cranial nerve which is responsible for conveying visual information from the retina to the brain http://purl.obolibrary.org/obo/MP_0001333 absent optic nerve http://purl.obolibrary.org/obo/MP_0001330 abnormal optic nerve morphology absence of the second cranial nerve which is responsible for conveying visual information from the retina to the brain http://purl.obolibrary.org/obo/MP_0001334 absent optic tract http://purl.obolibrary.org/obo/MP_0004267 abnormal optic tract morphology absence of the band of the paired bands of optic nerve fibers running from the optic chiasma mostly to the lateral geniculate body, with a smaller number of fibers terminating in the superior colliculus and the pretectal region http://purl.obolibrary.org/obo/MP_0001337 dry eyes http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology absence of natural or normal moisture in the eye http://purl.obolibrary.org/obo/MP_0001340 abnormal eyelid morphology http://purl.obolibrary.org/obo/MP_0002092 abnormal eye morphology any structural anomaly of the skin folds covering the front of the eyeball http://purl.obolibrary.org/obo/MP_0001341 absent eyelids http://purl.obolibrary.org/obo/MP_0001340 abnormal eyelid morphology missing skin folds covering the front of the eyeball when closed http://purl.obolibrary.org/obo/MP_0001343 pronounced eyelids http://purl.obolibrary.org/obo/MP_0001340 abnormal eyelid morphology strongly protruding eyelids http://purl.obolibrary.org/obo/MP_0001344 blepharoptosis http://purl.obolibrary.org/obo/MP_0001340 abnormal eyelid morphology ptosis, drooping eyelids http://purl.obolibrary.org/obo/MP_0001345 Meibomian gland atrophy http://purl.obolibrary.org/obo/MP_0005252 abnormal Meibomian gland morphology acquired diminution of the size of the sebaceous glands embedded in the tarsal plate of each eyelid, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0001346 abnormal lacrimal gland morphology http://purl.obolibrary.org/obo/MP_0008968 abnormal lacrimal apparatus morphology any structural anomaly of the glands that secrete tears http://purl.obolibrary.org/obo/MP_0001347 absent lacrimal glands http://purl.obolibrary.org/obo/MP_0001346 abnormal lacrimal gland morphology missing the glands that secrete tears http://purl.obolibrary.org/obo/MP_0001348 abnormal lacrimal gland physiology http://purl.obolibrary.org/obo/MP_0013450 abnormal lacrimal apparatus physiology any functional anomaly of the glands that secrete tears http://purl.obolibrary.org/obo/MP_0001349 excessive tearing http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology an unusually high amount of fluid in the eye, either oversecreted by the lacrimal glands, or due to imperfect drainage by the tear conducting passages, often resulting in overflow of fluid from the eye onto the cheek http://purl.obolibrary.org/obo/MP_0001353 increased aggression towards mice http://purl.obolibrary.org/obo/MP_0005655 increased aggression when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward other mice http://purl.obolibrary.org/obo/MP_0001354 increased aggression towards males http://purl.obolibrary.org/obo/MP_0001353 increased aggression towards mice when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward male mice http://purl.obolibrary.org/obo/MP_0001355 submission towards male mice http://purl.obolibrary.org/obo/MP_0005656 decreased aggression no domineering, assault posture nor hostile physical action toward male mice http://purl.obolibrary.org/obo/MP_0001356 increased aggression towards females http://purl.obolibrary.org/obo/MP_0001353 increased aggression towards mice when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward female mice http://purl.obolibrary.org/obo/MP_0001357 increased aggression toward humans http://purl.obolibrary.org/obo/MP_0005655 increased aggression when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward humans http://purl.obolibrary.org/obo/MP_0001358 aggression toward inanimate objects http://purl.obolibrary.org/obo/MP_0005655 increased aggression a domineering, assault posture and/or hostile physical action toward inanimate objects http://purl.obolibrary.org/obo/MP_0001360 abnormal social investigation http://purl.obolibrary.org/obo/MP_0002557 abnormal social/conspecific interaction altered behavior of animals to approach and examine other animals http://purl.obolibrary.org/obo/MP_0001361 social withdrawal http://purl.obolibrary.org/obo/MP_0001360 abnormal social investigation reclusive behavior; the tendency to refrain from participating in social situations and to seek isolation http://purl.obolibrary.org/obo/MP_0001362 abnormal anxiety-related response http://purl.obolibrary.org/obo/MP_0002065 abnormal fear/anxiety-related behavior altered emotional response related to anticipation of a non-specific threat http://purl.obolibrary.org/obo/MP_0001363 increased anxiety-related response http://purl.obolibrary.org/obo/MP_0001362 abnormal anxiety-related response when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests http://purl.obolibrary.org/obo/MP_0001364 decreased anxiety-related response http://purl.obolibrary.org/obo/MP_0001362 abnormal anxiety-related response when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests http://purl.obolibrary.org/obo/MP_0001375 abnormal mating preference http://purl.obolibrary.org/obo/MP_0002566 abnormal sexual interaction any change from the common preference of an initiating organism to initiate sexual contact with a receptive partner; in rodents, this usually refers to males that attempts to initiate sexual behavior with males and females indiscriminately http://purl.obolibrary.org/obo/MP_0001376 abnormal mating receptivity http://purl.obolibrary.org/obo/MP_0002566 abnormal sexual interaction deviation from the normal cycle or inability of females to respond favorably to males that initiate sexual behavior http://purl.obolibrary.org/obo/MP_0001377 abnormal mating frequency http://purl.obolibrary.org/obo/MP_0002566 abnormal sexual interaction increased, reduced or absent attempt of sexual behavioral contact between an initiating organism and a receptive partner http://purl.obolibrary.org/obo/MP_0001378 abnormal ejaculation http://purl.obolibrary.org/obo/MP_0003698 abnormal male reproductive system physiology anomalies in the ability to propulse semen from the genital ducts and the urethra to the exterior http://purl.obolibrary.org/obo/MP_0001379 abnormal penile erection http://purl.obolibrary.org/obo/MP_0009697 abnormal copulation altered ability to achieve a rigid state of the penis obtained in the condition in which the erectile tissue is filled with blood http://purl.obolibrary.org/obo/MP_0001380 reduced male mating frequency http://purl.obolibrary.org/obo/MP_0001377 abnormal mating frequency males do not as frequently initiate sexual behavior (as scored by the presence of copulation plugs in rodents, not due to infertility) http://purl.obolibrary.org/obo/MP_0001382 abnormal nursing http://purl.obolibrary.org/obo/MP_0001386 abnormal maternal nurturing females show anomlies in the feeding of offspring from mammary glands, or do not nurse offspring, or nurse offspring infrequently http://purl.obolibrary.org/obo/MP_0001384 abnormal pup retrieval http://purl.obolibrary.org/obo/MP_0009731 abnormal offspring retrieval any anomaly in the ability of a nesting female to retrieve stray pups to the nest or a delay in retrieving stray pups http://purl.obolibrary.org/obo/MP_0001385 pup cannibalization http://purl.obolibrary.org/obo/MP_0001386 abnormal maternal nurturing the killing and eating of newborn mice by the mother; however, this can be a normal response if the mother does not recognize the pups as her own http://purl.obolibrary.org/obo/MP_0001386 abnormal maternal nurturing http://purl.obolibrary.org/obo/MP_0008779 abnormal maternal behavior anomaly in the behaviors related to a female tending to young http://purl.obolibrary.org/obo/MP_0001388 abnormal stationary movement http://purl.obolibrary.org/obo/MP_0003491 abnormal voluntary movement altered ability or inability to change body posture or shift a body part http://purl.obolibrary.org/obo/MP_0001389 abnormal eye movement http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology deviation from the normal motility of the visual organs http://purl.obolibrary.org/obo/MP_0001391 abnormal tail movements http://purl.obolibrary.org/obo/MP_0001388 abnormal stationary movement a change from the normal manner of moving the tail http://purl.obolibrary.org/obo/MP_0001392 abnormal locomotor behavior http://purl.obolibrary.org/obo/MP_0003491 abnormal voluntary movement altered ability or inability to move from place to place in response to stimuli http://purl.obolibrary.org/obo/MP_0001393 ataxia http://purl.obolibrary.org/obo/MP_0003312 abnormal locomotor coordination inability to coordinate voluntary muscular movements http://purl.obolibrary.org/obo/MP_0001394 circling http://purl.obolibrary.org/obo/MP_0001408 stereotypic behavior repeated movement in a circle; often associated with inner ear defects http://purl.obolibrary.org/obo/MP_0001395 bidirectional circling http://purl.obolibrary.org/obo/MP_0001394 circling circling behavior exhibited in both clockwise and counterclockwise directions http://purl.obolibrary.org/obo/MP_0001396 unidirectional circling http://purl.obolibrary.org/obo/MP_0001394 circling circling behavior in one direction only, either clockwise or counterclockwise http://purl.obolibrary.org/obo/MP_0001399 hyperactivity http://purl.obolibrary.org/obo/MP_0003313 abnormal locomotor activation general restlessness or excessive movement; more frequent movement from one place to another or having an increased state of activity http://purl.obolibrary.org/obo/MP_0001400 hyperresponsive http://purl.obolibrary.org/obo/MP_0002067 abnormal sensory capabilities/reflexes/nociception increased reaction to touch http://purl.obolibrary.org/obo/MP_0001401 jumpy http://purl.obolibrary.org/obo/MP_0001516 abnormal motor coordination/ balance marked by fitful, jerky movements http://purl.obolibrary.org/obo/MP_0001402 hypoactivity http://purl.obolibrary.org/obo/MP_0003313 abnormal locomotor activation general reduced locomotor activity; reduced movement from one place to another or having a decreased state of activity http://purl.obolibrary.org/obo/MP_0001404 no spontaneous movement http://purl.obolibrary.org/obo/MP_0003313 abnormal locomotor activation failure of neonates or embryos to initiate any voluntary or spontaneous change in position or posture, with or without external stimulus http://purl.obolibrary.org/obo/MP_0001405 impaired coordination http://purl.obolibrary.org/obo/MP_0001516 abnormal motor coordination/ balance reduced ability to execute integrated movements of muscle http://purl.obolibrary.org/obo/MP_0001406 abnormal gait http://purl.obolibrary.org/obo/MP_0003312 abnormal locomotor coordination abnormal pattern of movement of the limbs of animals, characterized by elements of progression, stability, speed and length over the ground http://purl.obolibrary.org/obo/MP_0001407 short stride length http://purl.obolibrary.org/obo/MP_0001406 abnormal gait reduced average distance between steps http://purl.obolibrary.org/obo/MP_0001408 stereotypic behavior http://purl.obolibrary.org/obo/MP_0002066 abnormal motor capabilities/coordination/movement repetitive, invariant, perseverative motor patterns that do not appear to be purposeful http://purl.obolibrary.org/obo/MP_0001409 increased stereotypic behavior http://purl.obolibrary.org/obo/MP_0001408 stereotypic behavior more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful http://purl.obolibrary.org/obo/MP_0001410 head bobbing http://purl.obolibrary.org/obo/MP_0001408 stereotypic behavior repetitive up and down movement of the head http://purl.obolibrary.org/obo/MP_0001411 spinning http://purl.obolibrary.org/obo/MP_0001408 stereotypic behavior repetitive rolling of the body http://purl.obolibrary.org/obo/MP_0001412 excessive scratching http://purl.obolibrary.org/obo/MP_0001440 abnormal grooming behavior compulsive scraping of the skin, usually with the nails http://purl.obolibrary.org/obo/MP_0001413 abnormal response to new environment http://purl.obolibrary.org/obo/MP_0003107 abnormal response to novelty altered behavioral reaction associated with placing an animal in a new location http://purl.obolibrary.org/obo/MP_0001415 increased exploration in new environment http://purl.obolibrary.org/obo/MP_0013189 abnormal exploration in a new environment greater amount of time spent investigating new location http://purl.obolibrary.org/obo/MP_0001417 decreased exploration in new environment http://purl.obolibrary.org/obo/MP_0013189 abnormal exploration in a new environment less amount of time spent investigating a new location http://purl.obolibrary.org/obo/MP_0001422 abnormal drinking behavior http://purl.obolibrary.org/obo/MP_0002069 abnormal consumption behavior an altered pattern of fluid consumption or altered preference for particular fluids http://purl.obolibrary.org/obo/MP_0001423 abnormal liquid preference http://purl.obolibrary.org/obo/MP_0001422 abnormal drinking behavior the desire to drink more or less fluids than average, or to drink unusual fluids http://purl.obolibrary.org/obo/MP_0001425 abnormal alcohol consumption http://purl.obolibrary.org/obo/MP_0009745 abnormal behavioral response to xenobiotic aberrant behavioral-related or physiological-related intake of alcohol into the body http://purl.obolibrary.org/obo/MP_0001426 polydipsia http://purl.obolibrary.org/obo/MP_0011941 increased fluid intake abnormally large intake of fluids by mouth, usually due to excessive thirst that is relatively prolonged http://purl.obolibrary.org/obo/MP_0001428 adipsia http://purl.obolibrary.org/obo/MP_0001422 abnormal drinking behavior failure to drink http://purl.obolibrary.org/obo/MP_0001429 dehydration http://purl.obolibrary.org/obo/MP_0001784 abnormal fluid regulation excessive water loss from the body or from an organ or bodily part http://purl.obolibrary.org/obo/MP_0001431 abnormal eating behavior http://purl.obolibrary.org/obo/MP_0002069 abnormal consumption behavior altered ability to consume foods or atypical consumption pattern http://purl.obolibrary.org/obo/MP_0001432 abnormal food preference http://purl.obolibrary.org/obo/MP_0001431 abnormal eating behavior the desire to eat more or less food than average, or to eat unusual foods http://purl.obolibrary.org/obo/MP_0001433 polyphagia http://purl.obolibrary.org/obo/MP_0011939 increased food intake eating to excess http://purl.obolibrary.org/obo/MP_0001435 no suckling reflex http://purl.obolibrary.org/obo/MP_0001436 abnormal suckling behavior inability to orient and open/close mouth in sucking pattern in response to external light touching or stroking of the chin http://purl.obolibrary.org/obo/MP_0001436 abnormal suckling behavior http://purl.obolibrary.org/obo/MP_0001431 abnormal eating behavior reduced ability or inability to exert suction by the mouth, or atypical suckling pattern http://purl.obolibrary.org/obo/MP_0001437 no swallowing reflex http://purl.obolibrary.org/obo/MP_0001436 abnormal suckling behavior inability to pull food through the esophagus to the stomach in response to feeding http://purl.obolibrary.org/obo/MP_0001438 aphagia http://purl.obolibrary.org/obo/MP_0005449 abnormal food intake failure to eat http://purl.obolibrary.org/obo/MP_0001440 abnormal grooming behavior http://purl.obolibrary.org/obo/MP_0004924 abnormal behavior defects in the standard of behavior of cleaning and/or keeping outward appearance tidy (self, mate or offspring) http://purl.obolibrary.org/obo/MP_0001441 increased grooming behavior http://purl.obolibrary.org/obo/MP_0001440 abnormal grooming behavior increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring) http://purl.obolibrary.org/obo/MP_0001442 decreased grooming behavior http://purl.obolibrary.org/obo/MP_0001440 abnormal grooming behavior reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring) http://purl.obolibrary.org/obo/MP_0001443 poor grooming http://purl.obolibrary.org/obo/MP_0001440 abnormal grooming behavior below average standard of cleaning and/or keeping outward appearance tidy (self, mate or offspring) http://purl.obolibrary.org/obo/MP_0001446 abnormal whisker trimming behavior http://purl.obolibrary.org/obo/MP_0011000 abnormal allogrooming behavior anomaly in the behavior of plucking or biting off of the whiskers/vibrissae from other individuals of a cohort http://purl.obolibrary.org/obo/MP_0001447 abnormal nest building behavior http://purl.obolibrary.org/obo/MP_0002068 abnormal parental behavior deviation from the usual behavior of nesting animals to build sleeping nests out of any available materials, or of nesting animals to build nests to protect offspring http://purl.obolibrary.org/obo/MP_0001448 abnormal huddling behavior http://purl.obolibrary.org/obo/MP_0002557 abnormal social/conspecific interaction deviation from the usual tendency of mice to pile together when sleeping http://purl.obolibrary.org/obo/MP_0001454 abnormal cued conditioning behavior http://purl.obolibrary.org/obo/MP_0002062 abnormal associative learning anomaly in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash) http://purl.obolibrary.org/obo/MP_0001458 abnormal object recognition memory http://purl.obolibrary.org/obo/MP_0002063 abnormal learning/memory/conditioning anomaly in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time http://purl.obolibrary.org/obo/MP_0001460 abnormal olfactory -discrimination memory http://purl.obolibrary.org/obo/MP_0002802 abnormal discrimination learning anomaly in the ability to exhibit a differential response to olfactory stimuli that is achieved by the reinforcement of the desired response for each particular olfactory stimulus http://purl.obolibrary.org/obo/MP_0001462 abnormal avoidance learning behavior http://purl.obolibrary.org/obo/MP_0002062 abnormal associative learning anomaly in the ability to associate a previously neutral stimulus with an unpleasant or punishing stimuli so that the animal learns to avoid the previously neutral stimulus http://purl.obolibrary.org/obo/MP_0001463 abnormal spatial learning http://purl.obolibrary.org/obo/MP_0002063 abnormal learning/memory/conditioning anomaly in the ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues http://purl.obolibrary.org/obo/MP_0001468 abnormal temporal memory http://purl.obolibrary.org/obo/MP_0002063 abnormal learning/memory/conditioning anomaly in the ability to recall temporal events and stimuli http://purl.obolibrary.org/obo/MP_0001469 abnormal contextual conditioning behavior http://purl.obolibrary.org/obo/MP_0002062 abnormal associative learning anomaly in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case) http://purl.obolibrary.org/obo/MP_0001473 reduced long term potentiation http://purl.obolibrary.org/obo/MP_0002207 abnormal long term potentiation less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells http://purl.obolibrary.org/obo/MP_0001475 reduced long term depression http://purl.obolibrary.org/obo/MP_0001898 abnormal long term depression less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons http://purl.obolibrary.org/obo/MP_0001485 abnormal pinna reflex http://purl.obolibrary.org/obo/MP_0001961 abnormal reflex anomaly in the response to an auditory stimulus by a characteristic ear twitch http://purl.obolibrary.org/obo/MP_0001486 abnormal startle reflex http://purl.obolibrary.org/obo/MP_0001961 abnormal reflex aberrant threshold or reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch http://purl.obolibrary.org/obo/MP_0001488 increased startle reflex http://purl.obolibrary.org/obo/MP_0001486 abnormal startle reflex reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch http://purl.obolibrary.org/obo/MP_0001489 decreased startle reflex http://purl.obolibrary.org/obo/MP_0001486 abnormal startle reflex greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch http://purl.obolibrary.org/obo/MP_0001490 abnormal vibrissae reflex http://purl.obolibrary.org/obo/MP_0001961 abnormal reflex animals do not change position in response to stimulation of the whiskers http://purl.obolibrary.org/obo/MP_0001491 unresponsive to tactile stimuli http://purl.obolibrary.org/obo/MP_0005316 abnormal response to tactile stimuli absence of reflex action normally induced by touch or pain http://purl.obolibrary.org/obo/MP_0001492 abnormal pilomotor reflex http://purl.obolibrary.org/obo/MP_0001961 abnormal reflex anomaly in the involuntary bristling of hairs that occurs when an organism is cold or experiences strong emotions such as fear or awe http://purl.obolibrary.org/obo/MP_0001496 audiogenic seizures http://purl.obolibrary.org/obo/MP_0009358 environmentally induced seizures a reflex seizure triggered by loud noises http://purl.obolibrary.org/obo/MP_0001499 abnormal kindling response http://purl.obolibrary.org/obo/MP_0001650 abnormal seizure response to electrical stimulation any anomaly in the long-lasting epileptogenic changes normally induced by daily sub threshold electrical brain stimulation, often used as an induced model for epilepsy http://purl.obolibrary.org/obo/MP_0001500 reduced kindling response http://purl.obolibrary.org/obo/MP_0001499 abnormal kindling response fewer epileptogenic changes normally induced by daily sub threshold electrical brain stimulation http://purl.obolibrary.org/obo/MP_0001501 abnormal sleep pattern http://purl.obolibrary.org/obo/MP_0011396 abnormal sleep behavior deviation from the normal wake/sleep cycle http://purl.obolibrary.org/obo/MP_0001502 abnormal circadian rhythm http://purl.obolibrary.org/obo/MP_0004924 abnormal behavior deviation from the normal 24 hour biological activity cycle http://purl.obolibrary.org/obo/MP_0001504 abnormal posture http://purl.obolibrary.org/obo/MP_0002066 abnormal motor capabilities/coordination/movement atypical intentionally or habitually assumed position of the limbs or carriage of the body http://purl.obolibrary.org/obo/MP_0001505 hunched posture http://purl.obolibrary.org/obo/MP_0001504 abnormal posture stooped low with the limbs pulled in close to the body and arched back http://purl.obolibrary.org/obo/MP_0001506 limp posture http://purl.obolibrary.org/obo/MP_0001504 abnormal posture lack of rigidity of the carriage of the body http://purl.obolibrary.org/obo/MP_0001510 abnormal coat appearance http://purl.obolibrary.org/obo/MP_0000367 abnormal coat/ hair morphology anomaly in the visual apsect of the coat or hair http://purl.obolibrary.org/obo/MP_0001511 disheveled coat http://purl.obolibrary.org/obo/MP_0001510 abnormal coat appearance coat that looks generally unkempt http://purl.obolibrary.org/obo/MP_0001512 trunk curl http://purl.obolibrary.org/obo/MP_0001504 abnormal posture posture of the trunk in a curled position http://purl.obolibrary.org/obo/MP_0001513 limb grasping http://purl.obolibrary.org/obo/MP_0001961 abnormal reflex mice clasp front and/or hind feet almost immediately upon being lifted by tail http://purl.obolibrary.org/obo/MP_0001515 abnormal grip strength http://purl.obolibrary.org/obo/MP_0004262 abnormal physical strength altered ability to grasp and hold objects, often measured as time spent hanging from an object or wire http://purl.obolibrary.org/obo/MP_0001516 abnormal motor coordination/ balance http://purl.obolibrary.org/obo/MP_0002066 abnormal motor capabilities/coordination/movement altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium http://purl.obolibrary.org/obo/MP_0001522 impaired swimming http://purl.obolibrary.org/obo/MP_0003312 abnormal locomotor coordination reduced ability or inability to swim http://purl.obolibrary.org/obo/MP_0001523 impaired righting response http://purl.obolibrary.org/obo/MP_0002862 altered righting response reduced ability or greater amount of time needed to recover from an unnatural position to a normal position and/or to resist any force acting to place an organism into a false position http://purl.obolibrary.org/obo/MP_0001524 impaired limb coordination http://purl.obolibrary.org/obo/MP_0003312 abnormal locomotor coordination reduced ability to organize limb movements to execute complex maneuvers, such as walking http://purl.obolibrary.org/obo/MP_0001525 impaired balance http://purl.obolibrary.org/obo/MP_0001516 abnormal motor coordination/ balance reduced ability of an animal to maintain equilibrium http://purl.obolibrary.org/obo/MP_0001526 abnormal placing response http://purl.obolibrary.org/obo/MP_0001516 abnormal motor coordination/ balance altered ability to stretch and lift the forelimbs and head to grab a close edge http://purl.obolibrary.org/obo/MP_0001527 athetotic walking movements http://purl.obolibrary.org/obo/MP_0003312 abnormal locomotor coordination characterized by slow, writhing involuntary movements of flexion, extension, pronation and supination of the paws and toes http://purl.obolibrary.org/obo/MP_0001529 abnormal vocalization http://purl.obolibrary.org/obo/MP_0004924 abnormal behavior an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound http://purl.obolibrary.org/obo/MP_0001533 abnormal skeleton physiology http://purl.obolibrary.org/obo/MP_0005390 skeleton phenotype any functional anomaly of the bony framework of the body http://purl.obolibrary.org/obo/MP_0001539 decreased caudal vertebrae number http://purl.obolibrary.org/obo/MP_0004645 decreased vertebrae number reduced number of the bony segments of the tail or tail remnant http://purl.obolibrary.org/obo/MP_0001541 abnormal osteoclast physiology http://purl.obolibrary.org/obo/MP_0002998 abnormal bone remodeling any functional anomaly of the specialized phagocytic cells associated with the absorption and removal of the mineralized matrix of bone tissue http://purl.obolibrary.org/obo/MP_0001542 abnormal bone strength http://purl.obolibrary.org/obo/MP_0001533 abnormal skeleton physiology change in the ability of bone to endure the application of force without yielding or breaking http://purl.obolibrary.org/obo/MP_0001544 abnormal cardiovascular system physiology http://purl.obolibrary.org/obo/MP_0005385 cardiovascular system phenotype any functional anomaly of the heart or vascular tissue http://purl.obolibrary.org/obo/MP_0001545 abnormal hematopoietic system physiology http://purl.obolibrary.org/obo/MP_0005397 hematopoietic system phenotype any functional anomaly of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins http://purl.obolibrary.org/obo/MP_0001547 abnormal lipid level http://purl.obolibrary.org/obo/MP_0002118 abnormal lipid homeostasis any anomaly in the concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body http://purl.obolibrary.org/obo/MP_0001548 hyperlipidemia http://purl.obolibrary.org/obo/MP_0003949 abnormal circulating lipid level abnormally high concentration of lipids in the circulating blood http://purl.obolibrary.org/obo/MP_0001552 increased circulating triglyceride level http://purl.obolibrary.org/obo/MP_0011969 abnormal circulating triglyceride level greater concentration of naturally occurring esters of three fatty acids and glycerol in the blood; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver http://purl.obolibrary.org/obo/MP_0001553 abnormal circulating free fatty acids level http://purl.obolibrary.org/obo/MP_0010358 abnormal free fatty acids level any anomaly in the blood concentrations of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues http://purl.obolibrary.org/obo/MP_0001554 increased circulating free fatty acid level http://purl.obolibrary.org/obo/MP_0005281 increased fatty acid level higher than normal levels of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues http://purl.obolibrary.org/obo/MP_0001556 increased circulating HDL cholesterol level http://purl.obolibrary.org/obo/MP_0005178 increased circulating cholesterol level higher amount in the blood of the small lipoprotein:cholesterol complex that transports cholesterol out of the arteries and to the liver for reprocessing or excretion http://purl.obolibrary.org/obo/MP_0001559 hyperglycemia http://purl.obolibrary.org/obo/MP_0005559 increased circulating glucose level abnormally high concentration of glucose in the blood; generally refers to a pathological state http://purl.obolibrary.org/obo/MP_0001560 abnormal circulating insulin level http://purl.obolibrary.org/obo/MP_0005418 abnormal circulating hormone level any anomaly in the blood concentration of the polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids http://purl.obolibrary.org/obo/MP_0001562 abnormal circulating calcium level http://purl.obolibrary.org/obo/MP_0006357 abnormal circulating mineral level any anomaly in the concentration of calcium in the blood http://purl.obolibrary.org/obo/MP_0001565 abnormal circulating phosphate level http://purl.obolibrary.org/obo/MP_0006357 abnormal circulating mineral level any anomaly in the blood concentrations of the salt or ester of phosphoric acid http://purl.obolibrary.org/obo/MP_0001566 increased circulating phosphate level http://purl.obolibrary.org/obo/MP_0001565 abnormal circulating phosphate level abnormally high concentrations of phosphates in the circulating blood http://purl.obolibrary.org/obo/MP_0001569 abnormal circulating bilirubin level http://purl.obolibrary.org/obo/MP_0009642 abnormal blood homeostasis any anomaly in the concentration in the blood of the bile pigment bilirubin, normally found in the liver and in red blood cells http://purl.obolibrary.org/obo/MP_0001570 abnormal circulating enzyme level http://purl.obolibrary.org/obo/MP_0005416 abnormal circulating protein level aberrant concentration in the blood of any of the proteins that act as catalysts for biological reactions http://purl.obolibrary.org/obo/MP_0001573 abnormal circulating alanine transaminase level http://purl.obolibrary.org/obo/MP_0001570 abnormal circulating enzyme level aberrant concentration in the blood of the enzyme which transfers amino groups from l-alanine to 2-ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction http://purl.obolibrary.org/obo/MP_0001574 abnormal oxygen level http://purl.obolibrary.org/obo/MP_0003948 abnormal gas homeostasis any anomaly in the concentration of the gaseous element that is essential for animal and plant life http://purl.obolibrary.org/obo/MP_0001575 cyanosis http://purl.obolibrary.org/obo/MP_0009642 abnormal blood homeostasis a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood http://purl.obolibrary.org/obo/MP_0001577 anemia http://purl.obolibrary.org/obo/MP_0002429 abnormal blood cell morphology/development less than normal levels of red blood cells and/or hemoglobin within red blood cells, or volume of packed red blood cells in the bloodstream, resulting in insufficient oxygenation of tissues and organs http://purl.obolibrary.org/obo/MP_0001585 hemolytic anemia http://purl.obolibrary.org/obo/MP_0001577 anemia deficiency of red cells resulting from an increased rate of erythrocyte destruction http://purl.obolibrary.org/obo/MP_0001586 abnormal erythrocyte cell number http://purl.obolibrary.org/obo/MP_0011180 abnormal hematopoietic cell number altered number of the cells that transport oxygen, red blood cells, per unit http://purl.obolibrary.org/obo/MP_0001588 abnormal hemoglobin http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology defects in the levels or the function of the oxygen-carrying protein of erythrocytes http://purl.obolibrary.org/obo/MP_0001589 abnormal mean corpuscular hemoglobin http://purl.obolibrary.org/obo/MP_0001588 abnormal hemoglobin anomalies in the average levels of hemoglobin contained in an erythrocyte http://purl.obolibrary.org/obo/MP_0001596 hypotension http://purl.obolibrary.org/obo/MP_0002843 decreased systemic arterial blood pressure sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states http://purl.obolibrary.org/obo/MP_0001598 abnormal blood viscosity http://purl.obolibrary.org/obo/MP_0002128 abnormal blood circulation anomaly in the resistance to flow of the blood through the vessels http://purl.obolibrary.org/obo/MP_0001599 abnormal blood volume http://purl.obolibrary.org/obo/MP_0002128 abnormal blood circulation any anomaly in the amount of space occupied by the blood in the vessels http://purl.obolibrary.org/obo/MP_0001601 abnormal myelopoiesis http://purl.obolibrary.org/obo/MP_0005460 abnormal leukopoiesis anomaly in the process of, or atypical formation of myeloid cells from the pluripotent hematopoietic stem cells in the bone marrow from myeloid stem cells, including the production of leukocytes in blood, such as monocytes and granulocytes and precursor cells for macrophage and dendritic cells found in the lymphoid tissue http://purl.obolibrary.org/obo/MP_0001602 impaired myelopoiesis http://purl.obolibrary.org/obo/MP_0001601 abnormal myelopoiesis atypical process of bone marrow cell formation and/or the formation of bone marrow-derived blood cells with the result of fewer of these cells being formed http://purl.obolibrary.org/obo/MP_0001603 failure of myelopoiesis http://purl.obolibrary.org/obo/MP_0001601 abnormal myelopoiesis missing the process of bone marrow cell formation and/or the formation of bone marrow-derived blood cells http://purl.obolibrary.org/obo/MP_0001606 impaired hematopoiesis http://purl.obolibrary.org/obo/MP_0002123 abnormal hematopoiesis atypical process of blood cell formation with the result of fewer of these cells being formed http://purl.obolibrary.org/obo/MP_0001613 abnormal vasodilation http://purl.obolibrary.org/obo/MP_0005595 abnormal vascular smooth muscle physiology anomaly in the physiological widening of the lumen of the blood vessels by relaxing the underlying vascular smooth muscle http://purl.obolibrary.org/obo/MP_0001614 abnormal blood vessel morphology http://purl.obolibrary.org/obo/MP_0002127 abnormal cardiovascular system morphology any structural anomaly of the network of tubes that carries blood through the body http://purl.obolibrary.org/obo/MP_0001619 abnormal vascular permeability http://purl.obolibrary.org/obo/MP_0000249 abnormal blood vessel physiology anomaly in the ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases http://purl.obolibrary.org/obo/MP_0001622 abnormal vasculogenesis http://purl.obolibrary.org/obo/MP_0000259 abnormal vascular development aberrant process of the initial establishment of the vascular network http://purl.obolibrary.org/obo/MP_0001625 cardiac hypertrophy http://purl.obolibrary.org/obo/MP_0000274 enlarged heart an increase in size of the cardiac tissue, not due to increased cell number http://purl.obolibrary.org/obo/MP_0001627 abnormal cardiac output http://purl.obolibrary.org/obo/MP_0002128 abnormal blood circulation anomaly in the blood volume pumped by each ventricle per minute (stroke volume x heart rate) http://purl.obolibrary.org/obo/MP_0001629 abnormal heart rate http://purl.obolibrary.org/obo/MP_0004085 abnormal heartbeat greater than or fewer than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute http://purl.obolibrary.org/obo/MP_0001633 poor circulation http://purl.obolibrary.org/obo/MP_0002128 abnormal blood circulation insufficient movement of blood throughout the body, often manifesting in cold and/or pale skin http://purl.obolibrary.org/obo/MP_0001634 internal hemorrhage http://purl.obolibrary.org/obo/MP_0001914 hemorrhage blood loss in the interior of the body due to vessel rupture or dysmorphology http://purl.obolibrary.org/obo/MP_0001636 irregular heartbeat http://purl.obolibrary.org/obo/MP_0004085 abnormal heartbeat uneven timing of heart contraction http://purl.obolibrary.org/obo/MP_0001648 abnormal apoptosis http://purl.obolibrary.org/obo/MP_0000313 abnormal cell death excessive or absent cell death in a particular tissue or cell type http://purl.obolibrary.org/obo/MP_0001649 abnormal symphysis menti morphology http://purl.obolibrary.org/obo/MP_0000458 abnormal mandible morphology any structural anomaly of the fibrocartilagenous union of the two halves of the mandible (embryonic stages) http://purl.obolibrary.org/obo/MP_0001650 abnormal seizure response to electrical stimulation http://purl.obolibrary.org/obo/MP_0009357 abnormal seizure response to inducing agent anomaly in the seizure activity response that is brought about by high or low frequency electrical stimulation http://purl.obolibrary.org/obo/MP_0001652 colonic necrosis http://purl.obolibrary.org/obo/MP_0000495 abnormal colon morphology morphological changes resulting from pathological death of some or all colon tissue; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0001653 gastric necrosis http://purl.obolibrary.org/obo/MP_0000470 abnormal stomach morphology morphological changes resulting from pathological death of gastric tissue; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0001654 hepatic necrosis http://purl.obolibrary.org/obo/MP_0000598 abnormal liver morphology morphological changes resulting from pathological death of liver tissue; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0001655 multifocal hepatic necrosis http://purl.obolibrary.org/obo/MP_0001654 hepatic necrosis morphological changes resulting from multiple localized areas of pathological death of liver tissue; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0001656 focal hepatic necrosis http://purl.obolibrary.org/obo/MP_0001654 hepatic necrosis morphological changes resulting from one or more localized areas of pathological death of some or all liver tissue; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0001657 abnormal induced morbidity/mortality http://purl.obolibrary.org/obo/MP_0010768 mortality/aging differences from the expected diseased state or death caused by an external intervention http://purl.obolibrary.org/obo/MP_0001658 increased mortality induced by gamma-irradiation http://purl.obolibrary.org/obo/MP_0003992 increased mortality induced by ionizing radiation greater sensitivity to doses of ionizing radiation http://purl.obolibrary.org/obo/MP_0001661 extended life span http://purl.obolibrary.org/obo/MP_0010769 abnormal survival persistence of life for a longer period than is normal for an organism http://purl.obolibrary.org/obo/MP_0001663 abnormal digestive system physiology http://purl.obolibrary.org/obo/MP_0005381 digestive/alimentary phenotype any functional anomaly of the organ system that converts ingested food to nutrients and energy http://purl.obolibrary.org/obo/MP_0001664 abnormal digestion http://purl.obolibrary.org/obo/MP_0001663 abnormal digestive system physiology any anomaly of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism http://purl.obolibrary.org/obo/MP_0001665 chronic diarrhea http://purl.obolibrary.org/obo/MP_0005036 diarrhea prolonged diarrhea http://purl.obolibrary.org/obo/MP_0001666 abnormal intestinal absorption http://purl.obolibrary.org/obo/MP_0001664 abnormal digestion any anomaly in the quantity or rate of any nutrient taken up from the contents of the intestine http://purl.obolibrary.org/obo/MP_0001667 abnormal carbohydrate absorption http://purl.obolibrary.org/obo/MP_0001666 abnormal intestinal absorption any anomaly in the ability of the body to take in substances composed of carbon, hydrogen, and oxygen according to the general formula Cn(H2O)n; sugars and starches are examples http://purl.obolibrary.org/obo/MP_0001668 abnormal fructose absorption http://purl.obolibrary.org/obo/MP_0001667 abnormal carbohydrate absorption any anomaly in the ability of the body to take in fructose http://purl.obolibrary.org/obo/MP_0001669 abnormal glucose absorption http://purl.obolibrary.org/obo/MP_0001667 abnormal carbohydrate absorption any anomaly in the ability of the body to take in glucose http://purl.obolibrary.org/obo/MP_0001670 abnormal intestinal mineral absorption http://purl.obolibrary.org/obo/MP_0001666 abnormal intestinal absorption any anomaly in the ability of the body to take up inorganic substances that have importance in body functions into the blood by absorption from the small intestine http://purl.obolibrary.org/obo/MP_0001671 abnormal vitamin absorption http://purl.obolibrary.org/obo/MP_0004019 abnormal vitamin homeostasis any anomaly in the ability to take in any of a group of organic substances, present in food, that are essential to normal metabolism http://purl.obolibrary.org/obo/MP_0001672 abnormal embryogenesis/ development http://purl.obolibrary.org/obo/MP_0005380 embryogenesis phenotype anomaly in the establishment of the characteristic configuration of the embryonic body http://purl.obolibrary.org/obo/MP_0001674 abnormal triploblastic development http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology abnormal development of the three primary germ layers of the embryo http://purl.obolibrary.org/obo/MP_0001675 abnormal ectoderm development http://purl.obolibrary.org/obo/MP_0001674 abnormal triploblastic development any abnormality in the formation of the outer of the three primary germ layers of the embryo (the others being mesoderm and endoderm) that originates in the epiblast and is formed during gastrulation; ectoderm is in contact with the amnionic cavity and gives rise to two distinct lineages, i.e. the surface ectoderm and the neural ectoderm; it is the source of Rathke's pouch and forms the central and peripheral nervous systems, the sensory epithelia of the eye, ear, and nose, the epidermis and its appendages (nails and hair), the mammary, pituitary and subcutaneous glands, the tooth enamel, and the mucous membranes of the mouth and anus http://purl.obolibrary.org/obo/MP_0001676 abnormal apical ectodermal ridge morphology http://purl.obolibrary.org/obo/MP_0005650 abnormal limb bud morphology any structural anomaly of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme http://purl.obolibrary.org/obo/MP_0001677 absent apical ectodermal ridge http://purl.obolibrary.org/obo/MP_0001676 abnormal apical ectodermal ridge morphology missing the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme http://purl.obolibrary.org/obo/MP_0001678 thick apical ectodermal ridge http://purl.obolibrary.org/obo/MP_0001676 abnormal apical ectodermal ridge morphology increase in the thickness of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme http://purl.obolibrary.org/obo/MP_0001679 thin apical ectodermal ridge http://purl.obolibrary.org/obo/MP_0001676 abnormal apical ectodermal ridge morphology decrease in the thickness of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme http://purl.obolibrary.org/obo/MP_0001680 abnormal mesoderm development http://purl.obolibrary.org/obo/MP_0001674 abnormal triploblastic development failure or abnormality in the formation of the middle of the three primary germ layers of the embryo (the others being ectoderm and endoderm) during gastrulation; mesoderm is the origin of connective tissues, myoblasts, blood, the cardiovascular and lymphatic systems, most of the urogenital system, and the lining of the pericardial, pleural, and peritoneal cavities http://purl.obolibrary.org/obo/MP_0001683 absent mesoderm http://purl.obolibrary.org/obo/MP_0001680 abnormal mesoderm development absence of the middle of the three primary germ layers of the embryo (the others being ectoderm and endoderm) during gastrulation; mesoderm is the origin of connective tissues, myoblasts, blood, the cardiovascular and lymphatic systems, most of the urogenital system, and the lining of the pericardial, pleural, and peritoneal cavities http://purl.obolibrary.org/obo/MP_0001684 abnormal axial mesoderm http://purl.obolibrary.org/obo/MP_0001680 abnormal mesoderm development failure or abnormality in the formation of part of the middle of the three primary germ layers of the embryo which includes the prechordal mesoderm and the chordamesoderm and gives rise to the prechordal plate and to the notochord http://purl.obolibrary.org/obo/MP_0001685 abnormal endoderm development http://purl.obolibrary.org/obo/MP_0001674 abnormal triploblastic development any abnormality in the formation of the innermost of the three primary germ layers of the embryo (the others being mesoderm and ectoderm) during gastrulation; endoderm gives rise to the epithelial lining of the gastrointestinal and respiratory tracts; the parenchyma of the tonsils, the liver, the thymus, the thyroid, the parathyroids, and the pancreas; the epithelial lining of the urinary bladder, urethra, and prostate; and the epithelial lining of the tympanic cavity, tympanic antrum, and auditory tube http://purl.obolibrary.org/obo/MP_0001687 thin endoderm http://purl.obolibrary.org/obo/MP_0001685 abnormal endoderm development reduced thickness of the innermost germ layer of the embryo http://purl.obolibrary.org/obo/MP_0001688 abnormal somite development http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology any anomaly in the formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo; somites are transient structures - balls or blocks of paraxial mesoderm cells with an epithelial outer layer and a mesenchymal cell core - that emerge sequentially through a mesenchymal-to-epithelial transition (MET) from the morphologically unpatterned presomitic mesoderm; they give rise to the metameric anatomy of the vertebral column itself, and the associated skin, muscle and tendons http://purl.obolibrary.org/obo/MP_0001689 incomplete somite formation http://purl.obolibrary.org/obo/MP_0009768 impaired somite development arrest of differentiation or patterning of the somites http://purl.obolibrary.org/obo/MP_0001690 failure of somite differentiation http://purl.obolibrary.org/obo/MP_0009768 impaired somite development disorganized or absent somite tissue or somite pattern in development http://purl.obolibrary.org/obo/MP_0001691 abnormal somite shape http://purl.obolibrary.org/obo/MP_0001688 abnormal somite development anomaly in the characteristic surface outline or contour of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo http://purl.obolibrary.org/obo/MP_0001693 failure of primitive streak formation http://purl.obolibrary.org/obo/MP_0002230 abnormal primitive streak formation inability to form the epiblast ridge from which arises the germ layers of the embryo http://purl.obolibrary.org/obo/MP_0001694 failure to form egg cylinders http://purl.obolibrary.org/obo/MP_0003085 abnormal egg cylinder morphology inability of inner cell mass cells to grow towards the abembryonic pole to form a cylinder-like structure http://purl.obolibrary.org/obo/MP_0001695 abnormal gastrulation http://purl.obolibrary.org/obo/MP_0002084 abnormal developmental patterning any anomaly in the development and invagination of the embryonic germ layers http://purl.obolibrary.org/obo/MP_0001696 failure to gastrulate http://purl.obolibrary.org/obo/MP_0001695 abnormal gastrulation inability to differentiate and invaginate the primary germ layers http://purl.obolibrary.org/obo/MP_0001697 abnormal embryo size http://purl.obolibrary.org/obo/MP_0010866 abnormal prenatal body size any anomaly in the proportions of embryo compared to littermates (sensu Mus: up to E14, or the completion of organogenesis) http://purl.obolibrary.org/obo/MP_0001698 decreased embryo size http://purl.obolibrary.org/obo/MP_0001697 abnormal embryo size smaller proportions of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis) http://purl.obolibrary.org/obo/MP_0001699 increased embryo size http://purl.obolibrary.org/obo/MP_0001697 abnormal embryo size larger proportions of embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis) http://purl.obolibrary.org/obo/MP_0001700 abnormal embryo turning http://purl.obolibrary.org/obo/MP_0001695 abnormal gastrulation atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage during which the curvature of the entire trunk region is normally reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region http://purl.obolibrary.org/obo/MP_0001701 incomplete embryo turning http://purl.obolibrary.org/obo/MP_0001700 abnormal embryo turning arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage http://purl.obolibrary.org/obo/MP_0001704 abnormal dorsal-ventral axis patterning http://purl.obolibrary.org/obo/MP_0002084 abnormal developmental patterning anomaly in the development or formation of the axis that runs from the front to the back surface of the body http://purl.obolibrary.org/obo/MP_0001705 abnormal proximal-distal axis patterning http://purl.obolibrary.org/obo/MP_0002084 abnormal developmental patterning anomaly in the formation or development of a body structure, often a limb, in relation to the structure's proximity to the trunk or point of origin http://purl.obolibrary.org/obo/MP_0001706 abnormal left-right axis patterning http://purl.obolibrary.org/obo/MP_0002084 abnormal developmental patterning anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ http://purl.obolibrary.org/obo/MP_0001710 absent amniotic folds http://purl.obolibrary.org/obo/MP_0005029 abnormal amnion morphology failure of the amnion to form involutions http://purl.obolibrary.org/obo/MP_0001711 abnormal placenta morphology http://purl.obolibrary.org/obo/MP_0002086 abnormal extraembryonic tissue morphology any structural anomaly of the organ of metabolic interchange between fetus and mother, which is partly of embryonic origin and partly of maternal origin http://purl.obolibrary.org/obo/MP_0001712 abnormal placenta development http://purl.obolibrary.org/obo/MP_0001711 abnormal placenta morphology malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother http://purl.obolibrary.org/obo/MP_0001713 decreased trophoblast giant cell number http://purl.obolibrary.org/obo/MP_0005033 abnormal trophoblast giant cells fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta http://purl.obolibrary.org/obo/MP_0001714 absent trophoblast giant cells http://purl.obolibrary.org/obo/MP_0001713 decreased trophoblast giant cell number missing cells of the extraembryonic cell layer that contribute to the placenta http://purl.obolibrary.org/obo/MP_0001715 placental labyrinth hypoplasia http://purl.obolibrary.org/obo/MP_0011521 decreased placental labyrinth size underdevelopment or reduced size, usually due to a reduced number of cells, of the placental labyrinth, the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood http://purl.obolibrary.org/obo/MP_0001716 abnormal placenta labyrinth morphology http://purl.obolibrary.org/obo/MP_0001711 abnormal placenta morphology any structural anomaly of the placental layers where embryonic blood vessels are surrounded by trophoblast cells and maternal blood, and is the site where the exchange of nutrients and waste products occurs between the maternal and fetal circulation http://purl.obolibrary.org/obo/MP_0001717 absent ectoplacental cone http://purl.obolibrary.org/obo/MP_0005032 abnormal ectoplacental cone morphology missing the thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta http://purl.obolibrary.org/obo/MP_0001718 abnormal visceral yolk sac morphology http://purl.obolibrary.org/obo/MP_0002086 abnormal extraembryonic tissue morphology any structural anomaly of the extraembryonic tissue membrane, formed from the visceral endoderm and the extraembryonic mesoderm, which is located ventral to the embryonic disc and is connected to the presumptive midgut of the embryo; the yolk that it contains is the site of embryonic hematopoiesis and vitelline circulation is involved in early embryonic circulation; it is the origin of the primordial germ cells http://purl.obolibrary.org/obo/MP_0001719 absent vitelline blood vessels http://purl.obolibrary.org/obo/MP_0003229 abnormal vitelline vasculature morphology absence of the vascular network that supplies the yolk sac http://purl.obolibrary.org/obo/MP_0001721 absent visceral yolk sac blood islands http://purl.obolibrary.org/obo/MP_0011204 abnormal visceral yolk sac blood island morphology absence of the masses of developing blood cells attached to endothelium in the yolk sac http://purl.obolibrary.org/obo/MP_0001722 pale yolk sac http://purl.obolibrary.org/obo/MP_0001718 abnormal visceral yolk sac morphology bloodless yolk sac http://purl.obolibrary.org/obo/MP_0001723 disorganized yolk sac vascular plexus http://purl.obolibrary.org/obo/MP_0003229 abnormal vitelline vasculature morphology derangement in the pattern of the primary (honeycomb-like) vasculature of the yolk sac prior to remodeling into a mature vascular network http://purl.obolibrary.org/obo/MP_0001724 abnormal extraembryonic endoderm formation http://purl.obolibrary.org/obo/MP_0002086 abnormal extraembryonic tissue morphology malformation of the endoderm of the extraembryonic tissue that appears prior to gastrulation and performs critical functions during embryogenesis including nutrient uptake and transport from the mother to the embryo http://purl.obolibrary.org/obo/MP_0001725 abnormal umbilical cord morphology http://purl.obolibrary.org/obo/MP_0002086 abnormal extraembryonic tissue morphology any structural anomaly of the connective stalk between the fetus and the placenta http://purl.obolibrary.org/obo/MP_0001727 abnormal embryo implantation http://purl.obolibrary.org/obo/MP_0009661 abnormal pregnancy anomaly in the process in which the blastocyst and/or the uterine environment to successfully synchronize allowing attachment of the blastocyst to the epithelial lining of the uterus, its penetration through the epithelium and any subsequent physiological interactions necessary to sustain embryonic development http://purl.obolibrary.org/obo/MP_0001728 failure of embryo implantation http://purl.obolibrary.org/obo/MP_0001727 abnormal embryo implantation inability of the blastocyst and/or the uterine environment to successfully synchronize allowing attachment of the blastocyst to the epithelial lining of the uterus, its penetration through the epithelium and any subsequent physiological interactions necessary to sustain embryonic development http://purl.obolibrary.org/obo/MP_0001729 impaired embryo implantation http://purl.obolibrary.org/obo/MP_0001727 abnormal embryo implantation impaired ability of the blastocyst and/or the uterine environment to successfully synchronize allowing attachment of the blastocyst to the epithelial lining of the uterus, its penetration through the epithelium and any subsequent physiological interactions necessary to sustain embryonic development http://purl.obolibrary.org/obo/MP_0001730 embryonic growth arrest http://purl.obolibrary.org/obo/MP_0001672 abnormal embryogenesis/ development the cessation of development beyond a particular stage http://purl.obolibrary.org/obo/MP_0001731 abnormal postnatal growth http://purl.obolibrary.org/obo/MP_0002089 abnormal postnatal growth/weight/body size anomaly in reaching a developmental stage or stages after birth http://purl.obolibrary.org/obo/MP_0001732 postnatal growth retardation http://purl.obolibrary.org/obo/MP_0001731 abnormal postnatal growth slow or limited development after birth http://purl.obolibrary.org/obo/MP_0001739 abnormal adrenal gland secretion http://purl.obolibrary.org/obo/MP_0002909 abnormal adrenal gland physiology altered ability of the surparenal gland to produce or secrete hormones http://purl.obolibrary.org/obo/MP_0001740 failure of adrenal epinephrine secretion http://purl.obolibrary.org/obo/MP_0001739 abnormal adrenal gland secretion inability of adrenal gland to deliver epinephrine into the blood stream http://purl.obolibrary.org/obo/MP_0001742 absent circulating adrenaline http://purl.obolibrary.org/obo/MP_0005660 abnormal circulating adrenaline level absence in the circulation of a catecholamine hormone that stimulates the adrenergic receptors and causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels http://purl.obolibrary.org/obo/MP_0001743 absent circulating noradrenaline http://purl.obolibrary.org/obo/MP_0005663 abnormal circulating noradrenaline level absence of the hormone secreted by the adrenal medulla and acts as a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS; noradrenaline is the demethylated biosynthetic precursor of epinephrine http://purl.obolibrary.org/obo/MP_0001744 hypersecretion of corticosterone http://purl.obolibrary.org/obo/MP_0001739 abnormal adrenal gland secretion increased release of this adrenocortical steroid that induces glycogen deposition and regulates sodium conservation and potassium secretion http://purl.obolibrary.org/obo/MP_0001745 increased circulating corticosterone level http://purl.obolibrary.org/obo/MP_0005345 abnormal circulating corticosterone level greater than the normal amount of an adrenocortical steroid that induces glycogen deposition and regulates sodium conservation and potassium secretion http://purl.obolibrary.org/obo/MP_0001746 abnormal pituitary secretion http://purl.obolibrary.org/obo/MP_0005646 abnormal pituitary gland physiology anomaly in the production and/or release of biologically active substances from pituitary tissue http://purl.obolibrary.org/obo/MP_0001747 hypersecretion of adrenocorticotropin http://purl.obolibrary.org/obo/MP_0003347 hyperpituitarism increased release of this pituitary hormone from the pituitary gland that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex http://purl.obolibrary.org/obo/MP_0001748 increased circulating adrenocorticotropin level http://purl.obolibrary.org/obo/MP_0005129 increased adrenocorticotropin level elevated concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex http://purl.obolibrary.org/obo/MP_0001749 suppressed circulating follicle stimulating hormone level http://purl.obolibrary.org/obo/MP_0002790 decreased circulating follicle stimulating hormone level repression of secretion into the blood of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis http://purl.obolibrary.org/obo/MP_0001750 increased circulating follicle stimulating hormone level http://purl.obolibrary.org/obo/MP_0005131 increased follicle stimulating hormone level higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis http://purl.obolibrary.org/obo/MP_0001751 increased circulating luteinizing hormone level http://purl.obolibrary.org/obo/MP_0005133 increased luteinizing hormone level higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary http://purl.obolibrary.org/obo/MP_0001752 abnormal hypothalamus secretion http://purl.obolibrary.org/obo/MP_0005645 abnormal hypothalamus physiology altered ability of the hypothalamus to produce or release biologically active substances http://purl.obolibrary.org/obo/MP_0001753 hypersecretion of corticotropin-releasing hormone http://purl.obolibrary.org/obo/MP_0001752 abnormal hypothalamus secretion excessive release of this factor, which normally stimulates the pituitary to release adrenocorticotropic hormone, from the hypothalamus http://purl.obolibrary.org/obo/MP_0001754 increased circulating corticotropin-releasing hormone level http://purl.obolibrary.org/obo/MP_0005418 abnormal circulating hormone level higher than average amount of CRH in blood; CRH is normally released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland http://purl.obolibrary.org/obo/MP_0001756 abnormal urination http://purl.obolibrary.org/obo/MP_0005502 abnormal renal/urinary system physiology anomaly in the process in which parasympathetic nerves stimulate the bladder wall muscle to contract resulting in the expulsion of urine from the body http://purl.obolibrary.org/obo/MP_0001758 abnormal urine glucose level http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis any change in the amount of glucose in the urine http://purl.obolibrary.org/obo/MP_0001759 increased urine glucose level http://purl.obolibrary.org/obo/MP_0001758 abnormal urine glucose level a greater amount of glucose in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0001760 abnormal urine enzyme level http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis any change in the level of enzymes in the urine http://purl.obolibrary.org/obo/MP_0001761 abnormal urination pattern http://purl.obolibrary.org/obo/MP_0001756 abnormal urination increased or decreased frequency of urination episodes, or extended periods of anuria http://purl.obolibrary.org/obo/MP_0001762 polyuria http://purl.obolibrary.org/obo/MP_0001756 abnormal urination increased volume of urine produced and excreted http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis http://purl.obolibrary.org/obo/MP_0005376 homeostasis/metabolism phenotype anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the fluids and tissues http://purl.obolibrary.org/obo/MP_0001765 abnormal ion homeostasis http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis anomaly in the processes involved in the maintenance of an internal equilibrium of charged molecules in the fluids and tissues http://purl.obolibrary.org/obo/MP_0001770 abnormal iron level http://purl.obolibrary.org/obo/MP_0005637 abnormal iron homeostasis any anomaly in the concentrations of the metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins and is an essential component of enzymes such as catalase, peroxidase, and various cytochromes http://purl.obolibrary.org/obo/MP_0001771 abnormal circulating magnesium level http://purl.obolibrary.org/obo/MP_0011979 abnormal magnesium ion homeostasis any anomaly in the blood concentration of magnesium http://purl.obolibrary.org/obo/MP_0001775 abnormal selenium level http://purl.obolibrary.org/obo/MP_0000192 abnormal mineral level any anomaly in the concentration of selenium, which is required for glutathione peroxidase and other enzymes http://purl.obolibrary.org/obo/MP_0001776 abnormal circulating sodium level http://purl.obolibrary.org/obo/MP_0011977 abnormal sodium ion homeostasis any anomaly in the concentration in the blood of sodium, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume http://purl.obolibrary.org/obo/MP_0001777 abnormal body temperature homeostasis http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis any anomaly in the process in which an organism modulates or maintains its internal body temperature http://purl.obolibrary.org/obo/MP_0001778 abnormal brown adipose tissue amount http://purl.obolibrary.org/obo/MP_0005452 abnormal adipose tissue amount anomaly in the thermogenic form of adipose tissue that is composed of brown adipocytes http://purl.obolibrary.org/obo/MP_0001780 decreased brown adipose tissue amount http://purl.obolibrary.org/obo/MP_0001778 abnormal brown adipose tissue amount reduced quantity of the thermogenic form of adipose tissue that is composed of brown adipocytes http://purl.obolibrary.org/obo/MP_0001781 abnormal white adipose tissue amount http://purl.obolibrary.org/obo/MP_0005452 abnormal adipose tissue amount anomaly in the quantity of the white fat-storing cells/tissue http://purl.obolibrary.org/obo/MP_0001783 decreased white adipose tissue amount http://purl.obolibrary.org/obo/MP_0001781 abnormal white adipose tissue amount reduced quantity of fat-storing cells/tissue http://purl.obolibrary.org/obo/MP_0001784 abnormal fluid regulation http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis any anomaly in the control of intracellular and/or extracellular fluid http://purl.obolibrary.org/obo/MP_0001785 edema http://purl.obolibrary.org/obo/MP_0001784 abnormal fluid regulation an accumulation of an excessive amount of watery fluid in cells or intercellular tissues http://purl.obolibrary.org/obo/MP_0001786 skin edema http://purl.obolibrary.org/obo/MP_0001785 edema accumulation of an excessive amount of fluid in the skin layers or just underneath the skin http://purl.obolibrary.org/obo/MP_0001787 pericardial edema http://purl.obolibrary.org/obo/MP_0001785 edema accumulation of watery fluid in the pericardial sac of the heart http://purl.obolibrary.org/obo/MP_0001788 periorbital edema http://purl.obolibrary.org/obo/MP_0002092 abnormal eye morphology accumulation of an excessive amount of fluid in the area around the orbit http://purl.obolibrary.org/obo/MP_0001790 abnormal immune system physiology http://purl.obolibrary.org/obo/MP_0005387 immune system phenotype deviation from the normal function of the immune system http://purl.obolibrary.org/obo/MP_0001792 impaired wound healing http://purl.obolibrary.org/obo/MP_0005023 abnormal wound healing reduced ability or inability to self-repair and close wounds http://purl.obolibrary.org/obo/MP_0001793 altered susceptibility to infection http://purl.obolibrary.org/obo/MP_0005025 abnormal response to infection a change in the likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens http://purl.obolibrary.org/obo/MP_0001798 impaired macrophage phagocytosis http://purl.obolibrary.org/obo/MP_0002451 abnormal macrophage physiology reduced ability of macrophage phagocytic cells to internalize particulate matter http://purl.obolibrary.org/obo/MP_0001800 abnormal humoral immune response http://purl.obolibrary.org/obo/MP_0001790 abnormal immune system physiology any functional anomaly of the aspect of immunity that is mediated by secreted antibodies produced in the cells of the B lymphocyte lineage (B cell) and the accessory processes that accompany it, including Th2 activation and cytokine production, germinal center formation and isotype switching, affinity maturation and memory cell generation; it also refers to the effector functions of antibody, which include pathogen and toxin neutralization, classical complement activation, and opsonin promotion of phagocytosis and pathogen elimination http://purl.obolibrary.org/obo/MP_0001802 arrested B cell differentiation http://purl.obolibrary.org/obo/MP_0002144 abnormal B cell differentiation inability to produce mature B cells, and accumulation of B cell precursors http://purl.obolibrary.org/obo/MP_0001805 decreased IgG level http://purl.obolibrary.org/obo/MP_0020174 abnormal IgG level less than normal immunoglobulin class G level http://purl.obolibrary.org/obo/MP_0001806 decreased IgM level http://purl.obolibrary.org/obo/MP_0020180 abnormal IgM level less than normal immunoglobulin class M level http://purl.obolibrary.org/obo/MP_0001807 decreased IgA level http://purl.obolibrary.org/obo/MP_0020171 abnormal IgA level less than normal immunoglobulin class A level http://purl.obolibrary.org/obo/MP_0001819 abnormal immune cell physiology http://purl.obolibrary.org/obo/MP_0001790 abnormal immune system physiology any functional anomaly of the cells of the immune system http://purl.obolibrary.org/obo/MP_0001823 thymus hypoplasia http://purl.obolibrary.org/obo/MP_0000706 small thymus underdevelopment or reduced size, usually due to a reduced cell number, in the thymus http://purl.obolibrary.org/obo/MP_0001824 abnormal thymus involution http://purl.obolibrary.org/obo/MP_0003763 abnormal thymus physiology premature or late decline in thymic function normally associated with advancing age http://purl.obolibrary.org/obo/MP_0001825 arrested T cell differentiation http://purl.obolibrary.org/obo/MP_0002145 abnormal T cell differentiation failure of T cell formation to proceed past a defined stage http://purl.obolibrary.org/obo/MP_0001828 abnormal T cell activation http://purl.obolibrary.org/obo/MP_0002444 abnormal T cell physiology anomaly in the process of producing effector T cells from naive T cells http://purl.obolibrary.org/obo/MP_0001829 increased activated T cell number http://purl.obolibrary.org/obo/MP_0005015 increased T cell number greater than normal numbers of effector T cells http://purl.obolibrary.org/obo/MP_0001830 decreased activated T cell number http://purl.obolibrary.org/obo/MP_0005018 decreased T cell number reduced numbers of effector T cells http://purl.obolibrary.org/obo/MP_0001835 abnormal antigen presentation http://purl.obolibrary.org/obo/MP_0001790 abnormal immune system physiology aberration in the process by which by which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex http://purl.obolibrary.org/obo/MP_0001836 abnormal antigen presentation via MHC class I http://purl.obolibrary.org/obo/MP_0001835 abnormal antigen presentation anomaly in the process by which peptide, bound to major histocompatibility complex class I, is presented to lymphocytes at the surface of antigen presenting cells http://purl.obolibrary.org/obo/MP_0001837 defective assembly of class I molecules http://purl.obolibrary.org/obo/MP_0001836 abnormal antigen presentation via MHC class I impaired production of major histocompatibility complex class I molecules http://purl.obolibrary.org/obo/MP_0001838 defective intracellular transport of class I molecules http://purl.obolibrary.org/obo/MP_0001836 abnormal antigen presentation via MHC class I impaired ability to move major histocompatibility complex class I molecules to the cell surface http://purl.obolibrary.org/obo/MP_0001839 abnormal level of surface class I molecules http://purl.obolibrary.org/obo/MP_0001836 abnormal antigen presentation via MHC class I deviation from the normal concentration of major histocompatibility complex class I molecules expressed at the cell surface http://purl.obolibrary.org/obo/MP_0001840 increased level of surface class I molecules http://purl.obolibrary.org/obo/MP_0001839 abnormal level of surface class I molecules greater than normal expression of major histocompatibility complex class I molecules at the cell surface http://purl.obolibrary.org/obo/MP_0001841 decreased level of surface class I molecules http://purl.obolibrary.org/obo/MP_0001839 abnormal level of surface class I molecules reduced expression of major histocompatibility complex class I molecules at the cell surface http://purl.obolibrary.org/obo/MP_0001844 autoimmune response http://purl.obolibrary.org/obo/MP_0005005 abnormal self tolerance condition in which cells and/or antibodies arise from and are directed against one's own tissues http://purl.obolibrary.org/obo/MP_0001845 abnormal inflammatory response http://purl.obolibrary.org/obo/MP_0001790 abnormal immune system physiology aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues http://purl.obolibrary.org/obo/MP_0001846 increased inflammatory response http://purl.obolibrary.org/obo/MP_0001845 abnormal inflammatory response greater than expected response to injury, infection, or insult http://purl.obolibrary.org/obo/MP_0001847 brain inflammation http://purl.obolibrary.org/obo/MP_0006082 CNS inflammation local accumulation of fluid, plasma proteins, and leukocytes in the brain http://purl.obolibrary.org/obo/MP_0001848 choroid inflammation http://purl.obolibrary.org/obo/MP_0001851 eye inflammation local accumulation of fluid, plasma proteins, and leukocytes in the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera http://purl.obolibrary.org/obo/MP_0001849 ear inflammation http://purl.obolibrary.org/obo/MP_0003878 abnormal ear physiology local accumulation of fluid, plasma proteins and leukocytes in the ear http://purl.obolibrary.org/obo/MP_0001850 increased susceptibility to otitis media http://purl.obolibrary.org/obo/MP_0001849 ear inflammation greater likelihood of middle ear inflammation, with an accumulation of a thick, mucous-like fluid; usually associated with a viral or bacterial respiratory infection http://purl.obolibrary.org/obo/MP_0001851 eye inflammation http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology local accumulation of fluid, plasma proteins, and leukocytes in the eye http://purl.obolibrary.org/obo/MP_0001852 conjunctivitis http://purl.obolibrary.org/obo/MP_0001851 eye inflammation inflammation of the mucous membrane that lines the inner surface of the eyelids and the front of the eyeball http://purl.obolibrary.org/obo/MP_0001853 heart inflammation http://purl.obolibrary.org/obo/MP_0001846 increased inflammatory response local accumulation of fluid, plasma proteins, and leukocytes in the heart http://purl.obolibrary.org/obo/MP_0001854 atrial endocarditis http://purl.obolibrary.org/obo/MP_0001853 heart inflammation inflammation affecting the atrial chambers of the heart http://purl.obolibrary.org/obo/MP_0001855 atrial thrombosis http://purl.obolibrary.org/obo/MP_0005048 thrombosis formation or presence of a thrombus in the atria of the heart http://purl.obolibrary.org/obo/MP_0001856 myocarditis http://purl.obolibrary.org/obo/MP_0001853 heart inflammation inflammation of the heart walls http://purl.obolibrary.org/obo/MP_0001857 pericarditis http://purl.obolibrary.org/obo/MP_0001853 heart inflammation inflammation of the pericardium, the fibroserous sac surrounding the heart and the roots of the great vessels http://purl.obolibrary.org/obo/MP_0001858 intestinal inflammation http://purl.obolibrary.org/obo/MP_0010155 abnormal intestine physiology local accumulation of fluid, plasma proteins, and leukocytes in the intestine http://purl.obolibrary.org/obo/MP_0001859 kidney inflammation http://purl.obolibrary.org/obo/MP_0011762 renal/urinary system inflammation local accumulation of fluid, plasma proteins, and leukocytes in the kidney http://purl.obolibrary.org/obo/MP_0001860 liver inflammation http://purl.obolibrary.org/obo/MP_0001846 increased inflammatory response local accumulation of fluid, plasma proteins, and leukocytes in the liver http://purl.obolibrary.org/obo/MP_0001861 lung inflammation http://purl.obolibrary.org/obo/MP_0002405 respiratory system inflammation local accumulation of fluid, plasma proteins, and leukocytes in the lung http://purl.obolibrary.org/obo/MP_0001862 interstitial pneumonia http://purl.obolibrary.org/obo/MP_0001861 lung inflammation any of a group of inflammatory and fibrotic disorders of the lower respiratory tract, primarily affecting the supporting framework of the lung, including the alveolar wall, but may also involve the small airways and blood vessels of the lung parenchyma http://purl.obolibrary.org/obo/MP_0001863 vascular inflammation http://purl.obolibrary.org/obo/MP_0001846 increased inflammatory response local accumulation of fluid, plasma proteins, and leukocytes in a blood vessel http://purl.obolibrary.org/obo/MP_0001864 vasculitis http://purl.obolibrary.org/obo/MP_0001863 vascular inflammation inflammation of a blood or lymph vessel http://purl.obolibrary.org/obo/MP_0001866 nasal inflammation http://purl.obolibrary.org/obo/MP_0002405 respiratory system inflammation local accumulation of fluid, plasma proteins, and leukocytes in the proximal portion of the respiratory passages http://purl.obolibrary.org/obo/MP_0001867 rhinitis http://purl.obolibrary.org/obo/MP_0001866 nasal inflammation inflammation of the mucous membrane of the nose http://purl.obolibrary.org/obo/MP_0001868 ovary inflammation http://purl.obolibrary.org/obo/MP_0003699 abnormal female reproductive system physiology local accumulation of fluid, plasma proteins, and leukocytes in the ovary http://purl.obolibrary.org/obo/MP_0001869 pancreas inflammation http://purl.obolibrary.org/obo/MP_0002693 abnormal pancreas physiology local accumulation of fluid, plasma proteins, and leukocytes in the pancreas http://purl.obolibrary.org/obo/MP_0001870 salivary gland inflammation http://purl.obolibrary.org/obo/MP_0005310 abnormal salivary gland physiology local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland http://purl.obolibrary.org/obo/MP_0001872 sinus inflammation http://purl.obolibrary.org/obo/MP_0002405 respiratory system inflammation increase in susceptibility of the hollow cavities in bone (usually but not exclusively those in the skull) to allergens and/or pathogens http://purl.obolibrary.org/obo/MP_0001873 stomach inflammation http://purl.obolibrary.org/obo/MP_0001846 increased inflammatory response local accumulation of fluid, plasma proteins, and leukocytes in the stomach http://purl.obolibrary.org/obo/MP_0001874 acanthosis http://purl.obolibrary.org/obo/MP_0009611 epidermis stratum spinosum hyperplasia diffuse hyperplasia of the spinous layer of the skin http://purl.obolibrary.org/obo/MP_0001875 testis inflammation http://purl.obolibrary.org/obo/MP_0004884 abnormal testis physiology local accumulation of fluid, plasma proteins, and leukocytes in the testis http://purl.obolibrary.org/obo/MP_0001876 decreased inflammatory response http://purl.obolibrary.org/obo/MP_0001845 abnormal inflammatory response less than expected response to injury, infection, or insult http://purl.obolibrary.org/obo/MP_0001879 abnormal lymphatic vessel morphology http://purl.obolibrary.org/obo/MP_0000685 abnormal immune system morphology any structural anomaly of the network of vessels which carries lymph around the body http://purl.obolibrary.org/obo/MP_0001881 abnormal mammary gland physiology http://purl.obolibrary.org/obo/MP_0010680 abnormal skin adnexa physiology any functional anomaly of the compound, alveolar and apocrine milk-secreting gland that lies within the breast http://purl.obolibrary.org/obo/MP_0001882 abnormal lactation http://purl.obolibrary.org/obo/MP_0001881 abnormal mammary gland physiology atypical production of milk from the mammary gland http://purl.obolibrary.org/obo/MP_0001883 increased mammary adenocarcinoma incidence http://purl.obolibrary.org/obo/MP_0010299 increased mammary gland tumor incidence higher than normal incidence of malignant tumors of the mammary gland http://purl.obolibrary.org/obo/MP_0001884 mammary gland alveolar hyperplasia http://purl.obolibrary.org/obo/MP_0009506 abnormal mammary gland alveolus morphology overdevelopment or increased size, usually due an increased number of cells of the sac-like structure of the mammary gland that secretes milk after pregnancy http://purl.obolibrary.org/obo/MP_0001885 mammary gland duct hyperplasia http://purl.obolibrary.org/obo/MP_0009503 abnormal mammary gland duct morphology overdevelopment or increased size, usually due an increased number of cells of the tubular structure running from the nipple to the alveoli clusters in the mammary gland http://purl.obolibrary.org/obo/MP_0001889 delayed brain development http://purl.obolibrary.org/obo/MP_0000913 abnormal brain development the delay or slower progress of the growth and differentiation of the brain http://purl.obolibrary.org/obo/MP_0001890 anencephaly http://purl.obolibrary.org/obo/MP_0003861 abnormal nervous system development anomaly that occurs when the anterior neuropore of the neural tube fails to close, resulting in the congenital partial or complete absence of the cranial vault accompanied by absence of overlying tissues, including the brain and cerebral hemispheres, skull and scalp; in affected organisms, the forebrain remains in contact with the amniotic fluid and subsequently degenerates, including the cerebrum (areas responsible for cognition); any remaining brain tissue, such as the brain stem, is often exposed http://purl.obolibrary.org/obo/MP_0001891 hydroencephaly http://purl.obolibrary.org/obo/MP_0002200 abnormal brain ventricular system morphology excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma http://purl.obolibrary.org/obo/MP_0001893 non-obstructive hydrocephaly http://purl.obolibrary.org/obo/MP_0001891 hydroencephaly abnormal cerebrospinal fluid absorption where there is no obstruction to fluid flow in the ventricular system http://purl.obolibrary.org/obo/MP_0001898 abnormal long term depression http://purl.obolibrary.org/obo/MP_0002915 abnormal synaptic depression change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons http://purl.obolibrary.org/obo/MP_0001899 absent long term depression http://purl.obolibrary.org/obo/MP_0001898 abnormal long term depression lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons http://purl.obolibrary.org/obo/MP_0001900 impaired synaptic plasticity http://purl.obolibrary.org/obo/MP_0004859 abnormal synaptic plasticity decrease or inability of a synapse to change its strength as a result of successive activations http://purl.obolibrary.org/obo/MP_0001901 absence of NMDA-mediated synaptic currents http://purl.obolibrary.org/obo/MP_0002888 abnormal NMDA-mediated synaptic currents absence of a measured amplitude, current density or duration of response to stimulation of NMDA receptors http://purl.obolibrary.org/obo/MP_0001902 reduced NMDA-mediated synaptic currents http://purl.obolibrary.org/obo/MP_0002888 abnormal NMDA-mediated synaptic currents reduction in the measured amplitude, current density or duration of response to stimulation of NMDA receptors http://purl.obolibrary.org/obo/MP_0001905 abnormal dopamine level http://purl.obolibrary.org/obo/MP_0011479 abnormal catecholamine level greater or less than the normal amount of this catecholamine neurotransmitter and neurohormone, derived from tyrosine and the precursor to norepinephrine and epinephrine; functions as a neurotransmitter in the brain and as a hormone to inhibit the release of prolactin from the anterior lobe of the pituitary http://purl.obolibrary.org/obo/MP_0001906 increased dopamine level http://purl.obolibrary.org/obo/MP_0001905 abnormal dopamine level greater than the normal amount of this catecholamine neurotransmitter and neurohormone, derived from tyrosine and the precursor to norepinephrine and epinephrine; functions as a neurotransmitter in the brain and as a hormone to inhibit the release of prolactin from the anterior lobe of the pituitary http://purl.obolibrary.org/obo/MP_0001908 abnormal somatosensory cortex physiology http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology any functional anomaly of the area of the parietal lobe that lies posterior to the central sulcus and is concerned with receiving and processing general sensations from the body surface http://purl.obolibrary.org/obo/MP_0001909 reduced NMDA receptor mediated synaptic activity in barrel cortex http://purl.obolibrary.org/obo/MP_0002888 abnormal NMDA-mediated synaptic currents lower than normal levels of excitatory synaptic current in the barrel cortex http://purl.obolibrary.org/obo/MP_0001911 abnormal cerebrospinal fluid production http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology anomaly in the normal output of the fluid that fills the ventricles and other cavities of the brain and spinal cord http://purl.obolibrary.org/obo/MP_0001912 increased cerebrospinal fluid production http://purl.obolibrary.org/obo/MP_0001911 abnormal cerebrospinal fluid production increase in the normal output of the fluid that fills the ventricles and other cavities of the brain and spinal cord http://purl.obolibrary.org/obo/MP_0001913 decreased cerebrospinal fluid production http://purl.obolibrary.org/obo/MP_0001911 abnormal cerebrospinal fluid production reduction in the normal output of the fluid that fills the ventricles and other cavities of the brain and spinal cord http://purl.obolibrary.org/obo/MP_0001914 hemorrhage http://purl.obolibrary.org/obo/MP_0002128 abnormal blood circulation loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels http://purl.obolibrary.org/obo/MP_0001915 intracranial hemorrhage http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces http://purl.obolibrary.org/obo/MP_0001916 intracerebral hemorrhage http://purl.obolibrary.org/obo/MP_0001915 intracranial hemorrhage bleeding within the cerebrum http://purl.obolibrary.org/obo/MP_0001917 intraventricular hemorrhage http://purl.obolibrary.org/obo/MP_0001916 intracerebral hemorrhage bleeding into the brain ventricles http://purl.obolibrary.org/obo/MP_0001919 abnormal reproductive system physiology http://purl.obolibrary.org/obo/MP_0005389 reproductive system phenotype any functional anomaly of the organs associated with producing offspring http://purl.obolibrary.org/obo/MP_0001921 reduced fertility http://purl.obolibrary.org/obo/MP_0002161 abnormal fertility/fecundity diminished ability to produce live offspring http://purl.obolibrary.org/obo/MP_0001922 reduced male fertility http://purl.obolibrary.org/obo/MP_0003698 abnormal male reproductive system physiology reduced ability of male to produce live offspring http://purl.obolibrary.org/obo/MP_0001923 reduced female fertility http://purl.obolibrary.org/obo/MP_0003699 abnormal female reproductive system physiology reduced ability of female to produce live offspring http://purl.obolibrary.org/obo/MP_0001924 infertility http://purl.obolibrary.org/obo/MP_0002161 abnormal fertility/fecundity inability to produce live offspring http://purl.obolibrary.org/obo/MP_0001925 male infertility http://purl.obolibrary.org/obo/MP_0003698 abnormal male reproductive system physiology inability of male to produce live offspring http://purl.obolibrary.org/obo/MP_0001926 female infertility http://purl.obolibrary.org/obo/MP_0003699 abnormal female reproductive system physiology inability of female to produce live offspring http://purl.obolibrary.org/obo/MP_0001927 abnormal estrous cycle http://purl.obolibrary.org/obo/MP_0009344 abnormal ovulation cycle failure of progression or aberrant timing of the regular female reproductive cycle of non-primate placental mammals that is under hormonal control and includes a period of heat (mating receptivity), followed by ovulation and complex changes in the reproductive tract, followed by reabsorbtion of the endometrium if pregnancy does not occur http://purl.obolibrary.org/obo/MP_0001928 abnormal ovulation http://purl.obolibrary.org/obo/MP_0003699 abnormal female reproductive system physiology aberration in the release of an ovum from a rupturing Graafian follicle, normally regulated by a surge in luteinizing hormone http://purl.obolibrary.org/obo/MP_0001929 abnormal gametogenesis http://purl.obolibrary.org/obo/MP_0002160 abnormal reproductive system morphology defective formation or differentiation of germ cells http://purl.obolibrary.org/obo/MP_0001930 abnormal meiosis http://purl.obolibrary.org/obo/MP_0001929 abnormal gametogenesis anomaly in the process of nuclear division that results in gametes with one half the normal number of the original cell http://purl.obolibrary.org/obo/MP_0001931 abnormal oogenesis http://purl.obolibrary.org/obo/MP_0001929 abnormal gametogenesis atypical formation or failure to form the female germ cells http://purl.obolibrary.org/obo/MP_0001932 abnormal spermiogenesis http://purl.obolibrary.org/obo/MP_0001156 abnormal spermatogenesis anomaly in the process by which a spermatid transforms into a functional spermatozoon http://purl.obolibrary.org/obo/MP_0001933 abnormal litter size http://purl.obolibrary.org/obo/MP_0002161 abnormal fertility/fecundity deviation from the normal number of live born pups in a litter http://purl.obolibrary.org/obo/MP_0001934 increased litter size http://purl.obolibrary.org/obo/MP_0001933 abnormal litter size greater numbers of live born pups in a litter compared to average http://purl.obolibrary.org/obo/MP_0001935 decreased litter size http://purl.obolibrary.org/obo/MP_0001933 abnormal litter size fewer live born pups in a litter compared to average http://purl.obolibrary.org/obo/MP_0001937 abnormal sexual maturation http://purl.obolibrary.org/obo/MP_0002212 abnormal secondary sex determination a delay or a block in the development of the sexual organs at a given age http://purl.obolibrary.org/obo/MP_0001938 delayed sexual maturation http://purl.obolibrary.org/obo/MP_0001937 abnormal sexual maturation immaturity of the sexual organs at a given age http://purl.obolibrary.org/obo/MP_0001939 secondary sex reversal http://purl.obolibrary.org/obo/MP_0005652 sex reversal secondary sexual phenotype is not consistent with the chromosomal sex, i.e., internal and/or external genitalia are inconsistent with chromosomal sex http://purl.obolibrary.org/obo/MP_0001940 testis hypoplasia http://purl.obolibrary.org/obo/MP_0001147 small testis underdevelopment or reduced size, usually due to a reduced number of cells, in the testicles http://purl.obolibrary.org/obo/MP_0001942 abnormal lung volume http://purl.obolibrary.org/obo/MP_0001943 abnormal respiration anomaly in the amount of air that the lungs contain at various points of the respiratory cycle http://purl.obolibrary.org/obo/MP_0001943 abnormal respiration http://purl.obolibrary.org/obo/MP_0002133 abnormal respiratory system physiology anomaly in the movement of gases into and out of the lung http://purl.obolibrary.org/obo/MP_0001944 abnormal pancreas morphology http://purl.obolibrary.org/obo/MP_0002163 abnormal gland morphology any structural anomaly of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream http://purl.obolibrary.org/obo/MP_0001945 bronchoconstriction http://purl.obolibrary.org/obo/MP_0002314 abnormal respiratory mechanics reduction in the caliber of the bronchus or bronchi http://purl.obolibrary.org/obo/MP_0001947 abnormal mucociliary clearance http://purl.obolibrary.org/obo/MP_0002133 abnormal respiratory system physiology anomaly in the mechanism that removes mucus and other foreign particles and microorganisms from the lungs by directed ciliary movement and secretory activity of the tracheobronchial submucosal glands http://purl.obolibrary.org/obo/MP_0001948 vesicoureteral reflux http://purl.obolibrary.org/obo/MP_0002136 abnormal kidney physiology the retrograde flow of urine from the bladder into the ureters and kidneys http://purl.obolibrary.org/obo/MP_0001950 abnormal respiratory sounds http://purl.obolibrary.org/obo/MP_0001943 abnormal respiration any anomaly in the noises heard over any part of the respiratory tract http://purl.obolibrary.org/obo/MP_0001951 abnormal breathing pattern http://purl.obolibrary.org/obo/MP_0002327 abnormal respiratory function irregular or atypical breathing pattern, or absence of breathing http://purl.obolibrary.org/obo/MP_0001952 increased airway responsiveness http://purl.obolibrary.org/obo/MP_0002334 abnormal airway responsiveness more easily provoked into bronchoconstriction in bronchial provocation tests http://purl.obolibrary.org/obo/MP_0001953 respiratory failure http://purl.obolibrary.org/obo/MP_0001943 abnormal respiration cessation of or failure to commence breathing http://purl.obolibrary.org/obo/MP_0001954 respiratory distress http://purl.obolibrary.org/obo/MP_0001951 abnormal breathing pattern physical difficulty or inability to breathe; shortness of breath http://purl.obolibrary.org/obo/MP_0001956 hypopnea http://purl.obolibrary.org/obo/MP_0001951 abnormal breathing pattern breathing that is shallower and/or slower than normal http://purl.obolibrary.org/obo/MP_0001957 apnea http://purl.obolibrary.org/obo/MP_0001951 abnormal breathing pattern temporary cessation of breathing; sometimes episodic http://purl.obolibrary.org/obo/MP_0001958 emphysema http://purl.obolibrary.org/obo/MP_0010911 abnormal pulmonary acinus morphology an abnormal condition of the lung characterized by permanent enlargement of airspaces distal to the terminal bronchioles, accompanied by destruction of their walls and without obvious fibrosis; results in decreased respiratory function including increased air retention and reduced exchange of gases http://purl.obolibrary.org/obo/MP_0001961 abnormal reflex http://purl.obolibrary.org/obo/MP_0003492 abnormal involuntary movement anomaly in an involuntary response to a peripheral stimulus http://purl.obolibrary.org/obo/MP_0001963 abnormal hearing physiology http://purl.obolibrary.org/obo/MP_0003878 abnormal ear physiology any functional anomaly in the ability to perceive auditory stimuli http://purl.obolibrary.org/obo/MP_0001967 deafness http://purl.obolibrary.org/obo/MP_0006325 impaired hearing inability to hear; the ability to detect and/or recognize certain frequencies of sound is completely impaired http://purl.obolibrary.org/obo/MP_0001968 abnormal touch/ nociception http://purl.obolibrary.org/obo/MP_0010771 integument phenotype change in the ability to sense contact with objects or in the ability to sense pain, most often registered by mechanoreceptors in the skin and mucous membranes http://purl.obolibrary.org/obo/MP_0001970 abnormal pain threshold http://purl.obolibrary.org/obo/MP_0001968 abnormal touch/ nociception increased or decreased average level of perception of pain http://purl.obolibrary.org/obo/MP_0001973 increased thermal nociceptive threshold http://purl.obolibrary.org/obo/MP_0003043 hypoalgesia a greater than average point at which thermal pain sensation is first detectable http://purl.obolibrary.org/obo/MP_0001980 abnormal chemically-elicited antinociception http://purl.obolibrary.org/obo/MP_0001970 abnormal pain threshold change in the analgesic effect of chemical substances http://purl.obolibrary.org/obo/MP_0001981 increased chemically-elicited antinociception http://purl.obolibrary.org/obo/MP_0001980 abnormal chemically-elicited antinociception greater than the normal analgesic effect of chemical substances http://purl.obolibrary.org/obo/MP_0001982 decreased chemically-elicited antinociception http://purl.obolibrary.org/obo/MP_0001980 abnormal chemically-elicited antinociception less than the normal analgesic effect of chemical substances http://purl.obolibrary.org/obo/MP_0001983 abnormal olfactory system physiology http://purl.obolibrary.org/obo/MP_0005394 taste/olfaction phenotype any functional anomaly of the system relating to smell http://purl.obolibrary.org/obo/MP_0001984 abnormal olfaction http://purl.obolibrary.org/obo/MP_0001983 abnormal olfactory system physiology anomaly in the ability to smell http://purl.obolibrary.org/obo/MP_0001985 abnormal gustatory system physiology http://purl.obolibrary.org/obo/MP_0005394 taste/olfaction phenotype any functional anomaly in the perception of taste http://purl.obolibrary.org/obo/MP_0001986 abnormal taste sensitivity http://purl.obolibrary.org/obo/MP_0001985 abnormal gustatory system physiology changes in the ability to perceive a particular flavor or suggestion of something imparting a flavor by the chemoreceptors of the gustatory system http://purl.obolibrary.org/obo/MP_0001987 alcohol preference http://purl.obolibrary.org/obo/MP_0002553 preference for addictive substance predilection to ingest alcohol over other substances http://purl.obolibrary.org/obo/MP_0001988 cocaine preference http://purl.obolibrary.org/obo/MP_0002556 abnormal cocaine consumption predilection to ingest cocaine over other substances http://purl.obolibrary.org/obo/MP_0001993 abnormal blinking http://purl.obolibrary.org/obo/MP_0001961 abnormal reflex anomaly in the normal reflex of closing the eyes frequently and rapidly http://purl.obolibrary.org/obo/MP_0001994 increased blinking frequency http://purl.obolibrary.org/obo/MP_0001993 abnormal blinking greater number of occurrences of the normal reflex of closing the eyes frequently and rapidly http://purl.obolibrary.org/obo/MP_0001995 decreased blinking frequency http://purl.obolibrary.org/obo/MP_0001993 abnormal blinking reduced number of occurrences of the normal reflex of closing the eyes frequently and rapidly http://purl.obolibrary.org/obo/MP_0001999 photosensitivity http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology alterations in the response to sunlight or UV irradiation, especially sensitivity of the eyes http://purl.obolibrary.org/obo/MP_0002001 blindness http://purl.obolibrary.org/obo/MP_0002090 abnormal vision loss of the sense of sight http://purl.obolibrary.org/obo/MP_0002003 miotic pupils http://purl.obolibrary.org/obo/MP_0001317 abnormal pupil morphology contraction of the pupils http://purl.obolibrary.org/obo/MP_0002007 increased cellular sensitivity to gamma-irradiation http://purl.obolibrary.org/obo/MP_0004227 increased cellular sensitivity to ionizing radiation increased incidence of cell death following exposure to gamma-irradiation http://purl.obolibrary.org/obo/MP_0002009 preneoplasia http://purl.obolibrary.org/obo/MP_0002166 altered tumor susceptibility state preceding the pathological process resulting in a neoplasm; does not necessarily imply cancerous development http://purl.obolibrary.org/obo/MP_0002012 increased trichofolliculoma incidence http://purl.obolibrary.org/obo/MP_0009469 increased skin hamartoma incidence greater than the expected number of dome-shaped hamartoma tumors which contain multiple abortive and/or misaligned hair follicles http://purl.obolibrary.org/obo/MP_0002013 increased pilomatricoma incidence http://purl.obolibrary.org/obo/MP_0010300 increased skin tumor incidence greater than the expected number of neoplasms that arise from hair matrix cells occurring in a specific population in a given time period; pilomatricoma is an encapsulated tumor containing irregularly shaped, lobules of cells separated by fibrovascular connective tissue stroma; two distinct cell populations comprise this tumor, basaloid cells with scant cytoplasm located towards the periphery and the ghost (or shadow) cells occupying the central portion http://purl.obolibrary.org/obo/MP_0002014 increased papilloma incidence http://purl.obolibrary.org/obo/MP_0010273 increased classified tumor incidence greater than the expected number of benign tumors consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0002015 epithelioid cysts http://purl.obolibrary.org/obo/MP_0001191 abnormal skin condition abnormal membranous sacs appearing in an epithelium http://purl.obolibrary.org/obo/MP_0002016 ovary cysts http://purl.obolibrary.org/obo/MP_0001126 abnormal ovary morphology the appearance of fluid-filled sacs within the ovary http://purl.obolibrary.org/obo/MP_0002018 increased malignant tumor incidence http://purl.obolibrary.org/obo/MP_0010273 increased classified tumor incidence higher than normal incidence of locally invasive, destructive and metastatic tumors http://purl.obolibrary.org/obo/MP_0002019 abnormal tumor incidence http://purl.obolibrary.org/obo/MP_0002166 altered tumor susceptibility deviation from the expected number of abnormal growths in a specific population http://purl.obolibrary.org/obo/MP_0002020 increased tumor incidence http://purl.obolibrary.org/obo/MP_0002019 abnormal tumor incidence greater than the expected number of neoplasms in a specific population in a given time period, usually of a specific type http://purl.obolibrary.org/obo/MP_0002021 increased incidence of induced tumors http://purl.obolibrary.org/obo/MP_0013151 abnormal incidence of induced tumors higher than normal frequency of tumor incidence induced by a carcinogen, mutagen or virus http://purl.obolibrary.org/obo/MP_0002023 increased B cell derived lymphoma incidence http://purl.obolibrary.org/obo/MP_0012431 increased lymphoma incidence higher than normal incidence of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes http://purl.obolibrary.org/obo/MP_0002024 increased T cell derived lymphoma incidence http://purl.obolibrary.org/obo/MP_0012431 increased lymphoma incidence higher than normal incidence of a group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes http://purl.obolibrary.org/obo/MP_0002026 increased leukemia incidence http://purl.obolibrary.org/obo/MP_0010296 increased hemolymphoid system tumor incidence higher than normal incidence of a cancer characterized by progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood http://purl.obolibrary.org/obo/MP_0002027 increased lung adenocarcinoma incidence http://purl.obolibrary.org/obo/MP_0009308 increased adenocarcinoma incidence greater than the expected number of a malignant neoplasm of epithelial cells in the lung, usually with a glandular organization, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0002030 increased neurofibrosarcoma incidence http://purl.obolibrary.org/obo/MP_0010363 increased fibrosarcoma incidence greater than the expected number of a highly aggressive malignant neoplasm arising from the fibrous connective tissue surrounding peripheral nerves, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0002031 increased adrenal gland tumor incidence http://purl.obolibrary.org/obo/MP_0010288 increased gland tumor incidence greater than the expected number of neoplams in the adrenal gland occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0002032 increased sarcoma incidence http://purl.obolibrary.org/obo/MP_0002018 increased malignant tumor incidence greater than the expected number of a connective tissue neoplasm associated with the proliferation of embryonically-derived mesodermal cells, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0002033 increased malignant triton tumor incidence http://purl.obolibrary.org/obo/MP_0002018 increased malignant tumor incidence greater than the expected number of a malignant tumor with neurogenic and myogenic differentiation, occurring in a specific population in a given time period; usually arises in tissues of neural crest origin http://purl.obolibrary.org/obo/MP_0002035 increased leiomyosarcoma incidence http://purl.obolibrary.org/obo/MP_0010290 increased muscle tumor incidence greater than the expected number of a malignant tumor derived from smooth (nonstriated) muscle, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0002036 increased rhabdomyosarcoma incidence http://purl.obolibrary.org/obo/MP_0010290 increased muscle tumor incidence greater than the expected number of a malignant tumor derived from skeletal (striated) muscle, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0002037 increased fibrohistocytoma incidence http://purl.obolibrary.org/obo/MP_0010300 increased skin tumor incidence greater than the expected number of slowly growing skin nodules derived from cellular fibrous tissue occurring in a specific population in a given time period; these often surround capillaries http://purl.obolibrary.org/obo/MP_0002038 increased carcinoma incidence http://purl.obolibrary.org/obo/MP_0002018 increased malignant tumor incidence greater than the expected number of any of a variety of malignant neoplasms arising from epithelial cells, occurring in a specific population in a given time period; carcinomas are usually glandular or squamous in origin http://purl.obolibrary.org/obo/MP_0002039 increased neuroblastoma incidence http://purl.obolibrary.org/obo/MP_0010281 increased nervous system tumor incidence greater than the expected number of a malignant neoplasm characterized by immature nerve cells of embryonic type, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0002041 increased pituitary adenoma incidence http://purl.obolibrary.org/obo/MP_0010383 increased adenoma incidence greater than the expected number of benign neoplasms of the pituitary, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0002043 increased colon hamartoma incidence http://purl.obolibrary.org/obo/MP_0012436 increased colon tumor incidence greater than the expected number of benign focal malformations in the colon in a specific population in a given time period; results from faulty colonic development, and is composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element normally present at that site http://purl.obolibrary.org/obo/MP_0002044 increased colonic adenoma incidence http://purl.obolibrary.org/obo/MP_0010383 increased adenoma incidence greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the colon, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0002045 increased renal cystadenoma incidence http://purl.obolibrary.org/obo/MP_0010383 increased adenoma incidence greater than the expected number of a benign epithelial neoplasm with a glandular organization and a cyst-like appearance arising in the kidney, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0002047 increased hepatic hemangioma incidence http://purl.obolibrary.org/obo/MP_0008019 increased liver tumor incidence greater than the expected number of a benign tumor characterized by blood-filled spaces lined by benign endothelial cells in the liver, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0002048 increased lung adenoma incidence http://purl.obolibrary.org/obo/MP_0020190 abnormal lung adenoma incidence greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the lung, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0002049 increased extremity angiosarcoma incidence http://purl.obolibrary.org/obo/MP_0003667 increased hemangiosarcoma incidence higher than normal incidence of malignant neoplasm of soft tissues; thought to arise from endothelial cells of blood vessels http://purl.obolibrary.org/obo/MP_0002050 increased pheochromocytoma incidence http://purl.obolibrary.org/obo/MP_0002031 increased adrenal gland tumor incidence greater than the expected number of a benign neoplasm derived from adrenal medullary cells, occurring in a specific population in a given time period; usually associated with hypertension http://purl.obolibrary.org/obo/MP_0002051 increased skin papilloma incidence http://purl.obolibrary.org/obo/MP_0010300 increased skin tumor incidence greater than the expected number of a circumscribed, benign epithelial tumor projecting from the surrounding surface, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0002052 decreased tumor incidence http://purl.obolibrary.org/obo/MP_0002019 abnormal tumor incidence less than the expected number of neoplasms in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0002053 decreased incidence of induced tumors http://purl.obolibrary.org/obo/MP_0013151 abnormal incidence of induced tumors reduced frequency of tumor incidence induced by a carcinogen, mutagen or virus http://purl.obolibrary.org/obo/MP_0002058 neonatal lethality http://purl.obolibrary.org/obo/MP_0002081 perinatal lethality death within the neonatal period after birth (Mus: P0) http://purl.obolibrary.org/obo/MP_0002059 abnormal seminal vesicle morphology http://purl.obolibrary.org/obo/MP_0013330 abnormal male accessory sex gland morphology any structural anomaly of either of the paired sac-like glandular structures situated posterolateral to the urinary bladder in the male and functioning as part of the reproductive system; each sac is pyramidal in shape and convoluted in appearance and at the anterior extremity becomes constricted into a narrow straight duct that joins the ipsilateral vas deferens to form the ejaculatory duct; seminal vesicles secrete seminal fluid and nourish and promote the movement of spermatozoa through the urethra http://purl.obolibrary.org/obo/MP_0002060 abnormal skin morphology http://purl.obolibrary.org/obo/MP_0010771 integument phenotype any structural anomaly of the membranous protective covering of the body http://purl.obolibrary.org/obo/MP_0002061 abnormal aggression-related behavior http://purl.obolibrary.org/obo/MP_0002572 abnormal emotion/affect behavior domineering, assaultive or forceful physical action http://purl.obolibrary.org/obo/MP_0002062 abnormal associative learning http://purl.obolibrary.org/obo/MP_0002063 abnormal learning/memory/conditioning anomaly in the ability to change the frequency or form of a behavior as a result of the influence of the environment http://purl.obolibrary.org/obo/MP_0002063 abnormal learning/memory/conditioning http://purl.obolibrary.org/obo/MP_0004924 abnormal behavior altered ability to receive, store, process or recall informational stimuli http://purl.obolibrary.org/obo/MP_0002064 seizures http://purl.obolibrary.org/obo/MP_0004924 abnormal behavior sudden and often acute manifestation of epileptic attack, sometimes convulsive http://purl.obolibrary.org/obo/MP_0002065 abnormal fear/anxiety-related behavior http://purl.obolibrary.org/obo/MP_0002572 abnormal emotion/affect behavior altered response in tests for fear or anxiety related behaviors http://purl.obolibrary.org/obo/MP_0002066 abnormal motor capabilities/coordination/movement http://purl.obolibrary.org/obo/MP_0004924 abnormal behavior altered ability to coordinate voluntary movement or repetitive, compulsive movements http://purl.obolibrary.org/obo/MP_0002067 abnormal sensory capabilities/reflexes/nociception http://purl.obolibrary.org/obo/MP_0004924 abnormal behavior inability or altered ability to respond to a sensory stimulus http://purl.obolibrary.org/obo/MP_0002068 abnormal parental behavior http://purl.obolibrary.org/obo/MP_0002557 abnormal social/conspecific interaction altered behavior of animals that affects the ability of offspring to survive http://purl.obolibrary.org/obo/MP_0002069 abnormal consumption behavior http://purl.obolibrary.org/obo/MP_0004924 abnormal behavior altered ability or inability to eat or drink, or unusual choice or avoidance of foods or drink http://purl.obolibrary.org/obo/MP_0002073 abnormal hair growth http://purl.obolibrary.org/obo/MP_0001510 abnormal coat appearance absence or reduced amount of hair or abnormal onset of hair growth cycle or development, or abnormal hair pattern http://purl.obolibrary.org/obo/MP_0002074 abnormal hair texture http://purl.obolibrary.org/obo/MP_0001510 abnormal coat appearance irregular or unusual appearance of the structure of the hair http://purl.obolibrary.org/obo/MP_0002075 abnormal coat/hair pigmentation http://purl.obolibrary.org/obo/MP_0001510 abnormal coat appearance irregular or unusual pigmentation of the hair http://purl.obolibrary.org/obo/MP_0002078 abnormal glucose homeostasis http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis anomaly in the processes involved in the maintenance of an internal equilibrium of glucose in the fluids and tissues http://purl.obolibrary.org/obo/MP_0002079 increased circulating insulin level http://purl.obolibrary.org/obo/MP_0001560 abnormal circulating insulin level greater than normal levels of insulin in blood http://purl.obolibrary.org/obo/MP_0002080 prenatal lethality http://purl.obolibrary.org/obo/MP_0010770 preweaning lethality death anytime between fertilization and birth (Mus: approximately E18.5) http://purl.obolibrary.org/obo/MP_0002081 perinatal lethality http://purl.obolibrary.org/obo/MP_0010832 lethality during fetal growth through weaning death anytime within the perinatal period (Mus: E18.5 through postnatal day 1) http://purl.obolibrary.org/obo/MP_0002082 postnatal lethality http://purl.obolibrary.org/obo/MP_0010832 lethality during fetal growth through weaning premature death anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age) http://purl.obolibrary.org/obo/MP_0002083 premature death http://purl.obolibrary.org/obo/MP_0010769 abnormal survival death after weaning age, but before the normal life span (Mus: after 3 weeks of age) http://purl.obolibrary.org/obo/MP_0002084 abnormal developmental patterning http://purl.obolibrary.org/obo/MP_0001672 abnormal embryogenesis/ development abnormal systematic arrangement of the developing body along an axis http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology http://purl.obolibrary.org/obo/MP_0001672 abnormal embryogenesis/ development any structural anomaly or development of any embryonic tissue resulting in morphological abnormality http://purl.obolibrary.org/obo/MP_0002086 abnormal extraembryonic tissue morphology http://purl.obolibrary.org/obo/MP_0001672 abnormal embryogenesis/ development any structural anomaly of the membranes involved with embryonic protection and nutrition http://purl.obolibrary.org/obo/MP_0002088 abnormal embryonic growth/weight/body size http://purl.obolibrary.org/obo/MP_0004196 abnormal prenatal growth/weight/body size limited or accelerated growth or development apparent during the embryonic period (sensu Mus: up to E14, or the completion of organogenesis) http://purl.obolibrary.org/obo/MP_0002089 abnormal postnatal growth/weight/body size http://purl.obolibrary.org/obo/MP_0005378 growth/size/body phenotype increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth http://purl.obolibrary.org/obo/MP_0002090 abnormal vision http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology inability or decreased ability to see http://purl.obolibrary.org/obo/MP_0002092 abnormal eye morphology http://purl.obolibrary.org/obo/MP_0005391 vision/eye phenotype any structural anomaly of the spheroid organ and optic nerve that serves to detect light http://purl.obolibrary.org/obo/MP_0002095 abnormal skin pigmentation http://purl.obolibrary.org/obo/MP_0011239 abnormal skin coloration anomaly in the coloration of the skin due to changes in the amount, shape, or distribution of cells producing pigment http://purl.obolibrary.org/obo/MP_0002098 abnormal vibrissa morphology http://purl.obolibrary.org/obo/MP_0010678 abnormal skin adnexa morphology any structural anomaly of the stiff hairs projecting from the face around the nose of most mammals which act as touch receptors http://purl.obolibrary.org/obo/MP_0002100 abnormal tooth morphology http://purl.obolibrary.org/obo/MP_0000452 abnormal mouth morphology atypical size, shape or hard tissue structure of the teeth http://purl.obolibrary.org/obo/MP_0002102 abnormal ear morphology http://purl.obolibrary.org/obo/MP_0005377 hearing/vestibular/ear phenotype any structural anomaly of any of the structures involved in the ear or vestibular system http://purl.obolibrary.org/obo/MP_0002106 abnormal muscle physiology http://purl.obolibrary.org/obo/MP_0005369 muscle phenotype any functional anomaly of the muscle, not due to an anatomical defect http://purl.obolibrary.org/obo/MP_0002108 abnormal muscle morphology http://purl.obolibrary.org/obo/MP_0005369 muscle phenotype any structural anomaly of the contractile tissue that produces movement in animals http://purl.obolibrary.org/obo/MP_0002109 abnormal limb morphology http://purl.obolibrary.org/obo/MP_0005371 limbs/digits/tail phenotype any structural anomaly of the projecting paired appendages of an animal trunk, used in particular for movement and grasping; usually denotes the arm and/or legs in mammalian species http://purl.obolibrary.org/obo/MP_0002110 abnormal digit morphology http://purl.obolibrary.org/obo/MP_0000572 abnormal autopod morphology any structural anomaly of the fingers or toes http://purl.obolibrary.org/obo/MP_0002111 abnormal tail morphology http://purl.obolibrary.org/obo/MP_0005371 limbs/digits/tail phenotype any structural anomaly of the flexible elongated appendage located at the caudal end of the torso in many species; it is usually continuous with the vertebral column http://purl.obolibrary.org/obo/MP_0002113 abnormal skeleton development http://purl.obolibrary.org/obo/MP_0005508 abnormal skeleton morphology any anomaly in the formation of bone tissue http://purl.obolibrary.org/obo/MP_0002114 abnormal axial skeleton morphology http://purl.obolibrary.org/obo/MP_0005508 abnormal skeleton morphology any structural anomaly of the articulated bones of the cranium and vertebral column http://purl.obolibrary.org/obo/MP_0002115 abnormal limb bone morphology http://purl.obolibrary.org/obo/MP_0009250 abnormal appendicular skeleton morphology any structural anomaly of the limb or autopod bones http://purl.obolibrary.org/obo/MP_0002116 abnormal craniofacial bone morphology http://purl.obolibrary.org/obo/MP_0002114 abnormal axial skeleton morphology any structural anomaly of the cranial or facial bones http://purl.obolibrary.org/obo/MP_0002118 abnormal lipid homeostasis http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis anomaly in the processes involved in the maintenance of an internal equilibrium of lipids in the fluids and tissues http://purl.obolibrary.org/obo/MP_0002119 dipsosis http://purl.obolibrary.org/obo/MP_0001423 abnormal liquid preference excessive desire to drink, or to drink unusual fluids http://purl.obolibrary.org/obo/MP_0002123 abnormal hematopoiesis http://purl.obolibrary.org/obo/MP_0002429 abnormal blood cell morphology/development abnormal development of blood cells in the fetal and adult organism; in the fetus cells develop in the aorta, genital ridge and mesonephros region and later in the liver; in adults cells normally develop in the bone marrow and lymphatic tissues http://purl.obolibrary.org/obo/MP_0002127 abnormal cardiovascular system morphology http://purl.obolibrary.org/obo/MP_0005385 cardiovascular system phenotype any structural anomaly of the heart or vascular tissue http://purl.obolibrary.org/obo/MP_0002128 abnormal blood circulation http://purl.obolibrary.org/obo/MP_0001544 abnormal cardiovascular system physiology failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart http://purl.obolibrary.org/obo/MP_0002132 abnormal respiratory system morphology http://purl.obolibrary.org/obo/MP_0005388 respiratory system phenotype any structural anomaly of pulmonary tissues http://purl.obolibrary.org/obo/MP_0002133 abnormal respiratory system physiology http://purl.obolibrary.org/obo/MP_0005388 respiratory system phenotype any functional anomaly of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology http://purl.obolibrary.org/obo/MP_0000516 abnormal renal/urinary system morphology any structural anomaly of either of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine http://purl.obolibrary.org/obo/MP_0002136 abnormal kidney physiology http://purl.obolibrary.org/obo/MP_0005502 abnormal renal/urinary system physiology any functional anomaly and/or activity of either of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine http://purl.obolibrary.org/obo/MP_0002138 abnormal hepatobiliary system morphology http://purl.obolibrary.org/obo/MP_0005370 liver/biliary system phenotype any structural anomaly of any of the tissues of the liver or biliary system http://purl.obolibrary.org/obo/MP_0002139 abnormal hepatobiliary system physiology http://purl.obolibrary.org/obo/MP_0005370 liver/biliary system phenotype any functional anomaly of the tissues of the liver or biliary system http://purl.obolibrary.org/obo/MP_0002144 abnormal B cell differentiation http://purl.obolibrary.org/obo/MP_0004939 abnormal B cell morphology atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors http://purl.obolibrary.org/obo/MP_0002145 abnormal T cell differentiation http://purl.obolibrary.org/obo/MP_0008037 abnormal T cell morphology atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors http://purl.obolibrary.org/obo/MP_0002148 abnormal hypersensitivity reaction http://purl.obolibrary.org/obo/MP_0001790 abnormal immune system physiology immune response that results in tissue injury http://purl.obolibrary.org/obo/MP_0002151 abnormal neural tube morphology/development http://purl.obolibrary.org/obo/MP_0003861 abnormal nervous system development any structural anomaly of or development of the hollow epithelial tube found on the dorsal side of the vertebrate embryo that develops into the central nervous system (i.e. brain and spinal cord) http://purl.obolibrary.org/obo/MP_0002152 abnormal brain morphology http://purl.obolibrary.org/obo/MP_0003632 abnormal nervous system morphology any structural anomaly of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.) http://purl.obolibrary.org/obo/MP_0002160 abnormal reproductive system morphology http://purl.obolibrary.org/obo/MP_0005389 reproductive system phenotype structural or developmental anomaly of any of the tissues involved in the reproductive system http://purl.obolibrary.org/obo/MP_0002161 abnormal fertility/fecundity http://purl.obolibrary.org/obo/MP_0001919 abnormal reproductive system physiology anomaly in the reproductive capability of an organism or population to produce live offspring http://purl.obolibrary.org/obo/MP_0002163 abnormal gland morphology http://purl.obolibrary.org/obo/MP_0005379 endocrine/exocrine gland phenotype any structural anomaly of an organ that functions as a secretory or excretory organ http://purl.obolibrary.org/obo/MP_0002164 abnormal gland physiology http://purl.obolibrary.org/obo/MP_0005379 endocrine/exocrine gland phenotype any functional anomaly of an organ that functions as a secretory or excretory organ http://purl.obolibrary.org/obo/MP_0002166 altered tumor susceptibility http://purl.obolibrary.org/obo/MP_0002006 tumorigenesis greater than or less than the average number of tumors, usually a specific type, arising in a given organism when compared to controls http://purl.obolibrary.org/obo/MP_0002168 other aberrant phenotype http://purl.obolibrary.org/obo/MP_0005395 other phenotype anomaly or dysmorphology not attributable to any other category http://purl.obolibrary.org/obo/MP_0002169 no abnormal phenotype detected http://purl.obolibrary.org/obo/MP_0002873 normal phenotype normal, viable and fertile appearance and behavior; reported phenotype is indistinguishable from controls http://purl.obolibrary.org/obo/MP_0002174 abnormal gastrulation movements http://purl.obolibrary.org/obo/MP_0001695 abnormal gastrulation failure of embryonic cells to migrate, or migrate to the appropriate target during the development and invagination of the primary germ layers http://purl.obolibrary.org/obo/MP_0002175 decreased brain weight http://purl.obolibrary.org/obo/MP_0012775 abnormal brain weight lower than average weight of the brain http://purl.obolibrary.org/obo/MP_0002176 increased brain weight http://purl.obolibrary.org/obo/MP_0012775 abnormal brain weight greater than average weight of the brain http://purl.obolibrary.org/obo/MP_0002177 abnormal outer ear morphology http://purl.obolibrary.org/obo/MP_0002102 abnormal ear morphology any structural anomaly of any components of the auricles or external acoustic meatus http://purl.obolibrary.org/obo/MP_0002182 abnormal astrocyte morphology http://purl.obolibrary.org/obo/MP_0000952 abnormal CNS glial cell morphology any structural anomaly of the large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord; astrocytes are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier; astrocytes regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury http://purl.obolibrary.org/obo/MP_0002183 gliosis http://purl.obolibrary.org/obo/MP_0003634 abnormal glial cell morphology increased growth pattern of neuroglia in a damaged area of the brain or spinal cord http://purl.obolibrary.org/obo/MP_0002184 abnormal innervation http://purl.obolibrary.org/obo/MP_0003632 abnormal nervous system morphology the malformation, misprojection, abnormal fasciculation or abnormal refinement of the connection, of nerve fibers to a target http://purl.obolibrary.org/obo/MP_0002187 abnormal fibula morphology http://purl.obolibrary.org/obo/MP_0011504 abnormal limb long bone morphology any structural anomaly of the lateral and smaller bone of the lower limb http://purl.obolibrary.org/obo/MP_0002188 small heart http://purl.obolibrary.org/obo/MP_0005406 abnormal heart size reduced size of the heart relative to average http://purl.obolibrary.org/obo/MP_0002189 abnormal myocardial trabeculae morphology http://purl.obolibrary.org/obo/MP_0010630 abnormal cardiac muscle tissue morphology any structural anomaly of the supporting bundles of muscular fibers lining the walls of the heart http://purl.obolibrary.org/obo/MP_0002190 disorganized myocardium http://purl.obolibrary.org/obo/MP_0005329 abnormal myocardium layer morphology derangement of the pattern cardiac muscle layers http://purl.obolibrary.org/obo/MP_0002191 abnormal artery morphology http://purl.obolibrary.org/obo/MP_0001614 abnormal blood vessel morphology any structural anomaly of the blood vessels that carry blood away from the heart http://purl.obolibrary.org/obo/MP_0002192 hydrops fetalis http://purl.obolibrary.org/obo/MP_0001785 edema an abnormal accumulation of serous fluid in fetal tissues http://purl.obolibrary.org/obo/MP_0002193 minimal clonic seizures http://purl.obolibrary.org/obo/MP_0001650 abnormal seizure response to electrical stimulation seizures involving rhythmic face and forelimb clonus including arm movement, and it may include rearing and falling and ventral flexion of the neck; a seizure is scored as minimal when it satisfies the minimal criteria up to or including ventral flexion, but does not include maximal tonic hindlimb extension http://purl.obolibrary.org/obo/MP_0002194 maximal tonic hindlimb extension seizures http://purl.obolibrary.org/obo/MP_0001650 abnormal seizure response to electrical stimulation seizures induced by electrical stimulation of the brainstem; manifesting as a tonic-clonic flexion/extension sequence, starting in tonic extension of the forelimbs and terminating in a full tonic hindlimb extension, which is defined when the angle of the hindlimbs to the torso exceeds 90 degrees (although it is usually 180 degrees) http://purl.obolibrary.org/obo/MP_0002195 psychomotor seizures http://purl.obolibrary.org/obo/MP_0001650 abnormal seizure response to electrical stimulation low frequency, tetanic stimulation used to evoke partial limbic seizures, with currents ranging from 8 mA to 20 mA, depending on the strain and gender; manifesting as rhythmic face movements and extensive forelimb clonus (e.g. shadow-boxing forelimb movements), dorsal flexion of the neck, rearing and falling, and/or transient wobbliness/ataxia; seizure lasts only 10-15 seconds and when antiepileptic drugs are present may last only a few seconds http://purl.obolibrary.org/obo/MP_0002196 absent corpus callosum http://purl.obolibrary.org/obo/MP_0000780 abnormal corpus callosum morphology absence of the commissural plate interconnecting the cortical hemispheres of the brain http://purl.obolibrary.org/obo/MP_0002199 abnormal brain commissure morphology http://purl.obolibrary.org/obo/MP_0008026 abnormal brain white matter morphology any structural anomaly of any of the nerve fiber tracts that span the longitudinal fissure between the cerebral and/or cerebellar hemispheres of the brain http://purl.obolibrary.org/obo/MP_0002200 abnormal brain ventricular system morphology http://purl.obolibrary.org/obo/MP_0002152 abnormal brain morphology any structural anomaly of the brain ventricles, their associated choroid plexuses or the intercommunicating channels that connect the ventricular system http://purl.obolibrary.org/obo/MP_0002204 abnormal neurotransmitter level http://purl.obolibrary.org/obo/MP_0003635 abnormal synaptic transmission anomaly in the amount of endogenous signaling molecules into a synaptic cleft; neurotransmitters are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell http://purl.obolibrary.org/obo/MP_0002206 abnormal CNS synaptic transmission http://purl.obolibrary.org/obo/MP_0003635 abnormal synaptic transmission defect in the communication from a neuron to a target across a synapse in the central nervous system http://purl.obolibrary.org/obo/MP_0002207 abnormal long term potentiation http://purl.obolibrary.org/obo/MP_0002206 abnormal CNS synaptic transmission alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells http://purl.obolibrary.org/obo/MP_0002208 abnormal germ cell morphology http://purl.obolibrary.org/obo/MP_0001929 abnormal gametogenesis any structural anomaly of the germ cell, that is, any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated http://purl.obolibrary.org/obo/MP_0002209 decreased germ cell number http://purl.obolibrary.org/obo/MP_0002208 abnormal germ cell morphology reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated http://purl.obolibrary.org/obo/MP_0002210 abnormal sex determination http://purl.obolibrary.org/obo/MP_0002160 abnormal reproductive system morphology anomaly of primary or secondary sexual development or characteristics http://purl.obolibrary.org/obo/MP_0002211 abnormal primary sex determination http://purl.obolibrary.org/obo/MP_0002210 abnormal sex determination aberrant gonadal development resulting in either abnormal or absent gonads or the development of gonads inconsistent with the chromosomal sex http://purl.obolibrary.org/obo/MP_0002212 abnormal secondary sex determination http://purl.obolibrary.org/obo/MP_0002210 abnormal sex determination gonadal development may or may not be normal, and the phenotype of the animal outside the gonad does not match chromosomal sex or is ambiguous http://purl.obolibrary.org/obo/MP_0002213 true hermaphroditism http://purl.obolibrary.org/obo/MP_0002211 abnormal primary sex determination the presence of both unequivocal ovarian tissue and testicular elements in the same individual regardless of karyotype; these two tissue types may be present in the same gonad (ovotestis) or may be present as separate ovaries and testis tissue elements in the same individual regardless of sex chromosome complement http://purl.obolibrary.org/obo/MP_0002214 streak gonad http://purl.obolibrary.org/obo/MP_0003936 abnormal reproductive system development impairment of genital ridge development; aplasia of gonadal tissue which is sometimes replaced with functionless tissue http://purl.obolibrary.org/obo/MP_0002216 abnormal seminiferous tubule morphology http://purl.obolibrary.org/obo/MP_0001146 abnormal testis morphology any structural anomaly of the tubules in the testes where spermatogenesis occurs http://purl.obolibrary.org/obo/MP_0002217 small lymph nodes http://purl.obolibrary.org/obo/MP_0000701 abnormal lymph node size lymph nodes of decreased size http://purl.obolibrary.org/obo/MP_0002218 increased lymph node number http://purl.obolibrary.org/obo/MP_0000700 abnormal lymph node number greater than the normal number of lymph nodes http://purl.obolibrary.org/obo/MP_0002219 decreased lymph node number http://purl.obolibrary.org/obo/MP_0000700 abnormal lymph node number fewer than the normal number of lymph nodes http://purl.obolibrary.org/obo/MP_0002220 large lymphoid organs http://purl.obolibrary.org/obo/MP_0002221 abnormal lymph organ size increased size of lymphatic tissues http://purl.obolibrary.org/obo/MP_0002221 abnormal lymph organ size http://purl.obolibrary.org/obo/MP_0002722 abnormal immune system organ morphology change in the normal size of lymphatic tissues http://purl.obolibrary.org/obo/MP_0002223 lymphoid hypoplasia http://purl.obolibrary.org/obo/MP_0000687 small lymphoid organs underdevelopment or reduced size, usually due to a reduced cell number, in lymphatic tissue http://purl.obolibrary.org/obo/MP_0002224 abnormal spleen size http://purl.obolibrary.org/obo/MP_0002221 abnormal lymph organ size deviation from the normal spleen size http://purl.obolibrary.org/obo/MP_0002227 abnormal spleen capsule morphology http://purl.obolibrary.org/obo/MP_0000689 abnormal spleen morphology any structural anomaly of the connective tissue that surrounds the spleen http://purl.obolibrary.org/obo/MP_0002228 abnormal spleen trabecular vein morphology http://purl.obolibrary.org/obo/MP_0000689 abnormal spleen morphology any structural anomaly of one of the veins that feed the splenic vein http://purl.obolibrary.org/obo/MP_0002229 neurodegeneration http://purl.obolibrary.org/obo/MP_0003632 abnormal nervous system morphology a retrogressive impairment of function or destruction of neural tissue http://purl.obolibrary.org/obo/MP_0002230 abnormal primitive streak formation http://purl.obolibrary.org/obo/MP_0002231 abnormal primitive streak morphology anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm http://purl.obolibrary.org/obo/MP_0002231 abnormal primitive streak morphology http://purl.obolibrary.org/obo/MP_0001695 abnormal gastrulation anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm http://purl.obolibrary.org/obo/MP_0002233 abnormal nose morphology http://purl.obolibrary.org/obo/MP_0003743 abnormal facial morphology any structural anomaly of the organ that is specialized for smell and is part of the respiratory system http://purl.obolibrary.org/obo/MP_0002234 abnormal pharynx morphology http://purl.obolibrary.org/obo/MP_0002132 abnormal respiratory system morphology any structural anomaly in the passage between the mouth and the posterior nares and the larynx and esophagus http://purl.obolibrary.org/obo/MP_0002235 abnormal external nares morphology http://purl.obolibrary.org/obo/MP_0002233 abnormal nose morphology any structural anomaly of the anterior opening to the nasal cavity http://purl.obolibrary.org/obo/MP_0002236 abnormal internal nares morphology http://purl.obolibrary.org/obo/MP_0002233 abnormal nose morphology any structural anomaly of the portion of the opening of the nasal cavity into the nasal pharynx http://purl.obolibrary.org/obo/MP_0002237 abnormal nasal cavity morphology http://purl.obolibrary.org/obo/MP_0002233 abnormal nose morphology any structural anomaly of the portion of the respiratory tract that extends from the nares to the pharynx; the nasal cavity is lined with ciliated mucosa http://purl.obolibrary.org/obo/MP_0002238 abnormal nasal mucosa morphology http://purl.obolibrary.org/obo/MP_0002277 abnormal respiratory mucosa morphology any structural anomaly of the mucous membrane that lines the nasal cavity http://purl.obolibrary.org/obo/MP_0002239 abnormal nasal septum morphology http://purl.obolibrary.org/obo/MP_0002233 abnormal nose morphology any structural anomaly of the structure that separates the two nasal cavities http://purl.obolibrary.org/obo/MP_0002240 abnormal paranasal sinus morphology http://purl.obolibrary.org/obo/MP_0003743 abnormal facial morphology any structural anomaly of the paired air-filled cavities surrounded by the bones of the face that are lined by mucous membranes and are continuous with the nasal cavity http://purl.obolibrary.org/obo/MP_0002241 abnormal laryngeal mucosa goblet cell morphology http://purl.obolibrary.org/obo/MP_0002261 abnormal laryngeal mucosa morphology any structural anomaly of the epithelial cells lining the larynx, which produce mucins http://purl.obolibrary.org/obo/MP_0002242 abnormal olfactory mucosa morphology http://purl.obolibrary.org/obo/MP_0002238 abnormal nasal mucosa morphology any structural anomaly of the portion of the nasal mucosa that contains the olfactory sensory endings http://purl.obolibrary.org/obo/MP_0002243 abnormal vomeronasal organ morphology http://purl.obolibrary.org/obo/MP_0002239 abnormal nasal septum morphology any structural anomaly of the specialized portion of the nasal septum that is composed of chemosensitive cells that respond to pheromones and lies anteriorly in the nasal cavity http://purl.obolibrary.org/obo/MP_0002244 abnormal turbinate morphology http://purl.obolibrary.org/obo/MP_0005274 abnormal viscerocranium morphology any structural anomaly of the small curved bones that extends horizontally along the lateral wall of the nasal passage http://purl.obolibrary.org/obo/MP_0002245 abnormal ethmoid sinus morphology http://purl.obolibrary.org/obo/MP_0002240 abnormal paranasal sinus morphology any structural anomaly of the evaginations of the mucous membrane of the nasal cavity into the ethmoidal bony labyrinth, forming multiple small paranasal sinuses http://purl.obolibrary.org/obo/MP_0002246 abnormal frontal sinus morphology http://purl.obolibrary.org/obo/MP_0002240 abnormal paranasal sinus morphology any structural anomaly of the paired evaginations of the mucous membrane of the nasal cavity into the lower part of the squama of the frontal bones http://purl.obolibrary.org/obo/MP_0002247 abnormal maxillary sinus morphology http://purl.obolibrary.org/obo/MP_0002240 abnormal paranasal sinus morphology any structural anomaly of the paired evaginations of the mucous membrane of the nasal cavity into the air space located within the maxilla http://purl.obolibrary.org/obo/MP_0002248 abnormal sphenoid sinus morphology http://purl.obolibrary.org/obo/MP_0002240 abnormal paranasal sinus morphology any structural anomaly of the paired evaginations of the mucous membrane of the nasal cavity into the air space located within the sphenoid bone, and which communicates with the upper posterior nasal cavity or sphenoethmoidal recess http://purl.obolibrary.org/obo/MP_0002249 abnormal larynx morphology http://purl.obolibrary.org/obo/MP_0002132 abnormal respiratory system morphology any structural anomaly of the organ of voice production located between the pharynx and the trachea http://purl.obolibrary.org/obo/MP_0002250 abnormal hypopharynx morphology http://purl.obolibrary.org/obo/MP_0002234 abnormal pharynx morphology any structural anomaly in the portion of the pharynx that lies below the upper edge of the epiglottis and opens into the larynx and the esophagus http://purl.obolibrary.org/obo/MP_0002251 abnormal nasopharynx morphology http://purl.obolibrary.org/obo/MP_0002234 abnormal pharynx morphology any structural anomaly of the section of the pharynx that lies above the soft palate http://purl.obolibrary.org/obo/MP_0002252 abnormal oropharynx morphology http://purl.obolibrary.org/obo/MP_0002234 abnormal pharynx morphology any structural anomaly of the portion of the pharynx that lies between the soft palate and the upper edge of the epiglottis http://purl.obolibrary.org/obo/MP_0002253 abnormal pharyngeal muscle morphology http://purl.obolibrary.org/obo/MP_0002234 abnormal pharynx morphology any structural anomaly of any of the muscles of the pharynx, the inferior, middle and superior constrictors, salpingopharyngeus, and stylopharyngeus http://purl.obolibrary.org/obo/MP_0002254 reproductive system inflammation http://purl.obolibrary.org/obo/MP_0001919 abnormal reproductive system physiology local accumulation of fluid, plasma proteins, and leukocytes in any of the reproductive organs http://purl.obolibrary.org/obo/MP_0002255 abnormal glottis morphology http://purl.obolibrary.org/obo/MP_0002249 abnormal larynx morphology any structural anomaly of the vocal apparatus of the larynx, which includes the vocal cords and the opening between them http://purl.obolibrary.org/obo/MP_0002256 abnormal laryngeal cartilage morphology http://purl.obolibrary.org/obo/MP_0002249 abnormal larynx morphology any structural anomaly of the cartilaginous structures that support the larynx http://purl.obolibrary.org/obo/MP_0002257 abnormal arytenoid cartilage morphology http://purl.obolibrary.org/obo/MP_0002256 abnormal laryngeal cartilage morphology any structural anomaly of the paired triangular cartilages located postlaterally at the level of the thyroid cartilage http://purl.obolibrary.org/obo/MP_0002258 abnormal cricoid cartilage morphology http://purl.obolibrary.org/obo/MP_0002256 abnormal laryngeal cartilage morphology any structural anomaly of the most inferior of the laryngeal cartilages http://purl.obolibrary.org/obo/MP_0002260 abnormal thyroid cartilage morphology http://purl.obolibrary.org/obo/MP_0002256 abnormal laryngeal cartilage morphology any structural anomaly of the largest of the laryngeal cartilages http://purl.obolibrary.org/obo/MP_0002261 abnormal laryngeal mucosa morphology http://purl.obolibrary.org/obo/MP_0002277 abnormal respiratory mucosa morphology any structural anomaly of the mucous lining of the larynx, which is composed of squamous epithelium in the upper larynx and ciliated columnar epithelium in the lower larynx http://purl.obolibrary.org/obo/MP_0002262 abnormal nasal mucosa goblet cell morphology http://purl.obolibrary.org/obo/MP_0002238 abnormal nasal mucosa morphology any structural anomaly of the cells lining the nasal epithelium that produce and secrete mucins http://purl.obolibrary.org/obo/MP_0002263 abnormal laryngeal muscle morphology http://purl.obolibrary.org/obo/MP_0002249 abnormal larynx morphology any structural anomaly of the muscles associated with the larynx http://purl.obolibrary.org/obo/MP_0002264 abnormal bronchus morphology http://purl.obolibrary.org/obo/MP_0004391 abnormal respiratory conducting tube morphology any structural anomaly of the upper conducting airways of the lung; these airways arise from the terminus of the trachea http://purl.obolibrary.org/obo/MP_0002265 abnormal left major bronchus morphology http://purl.obolibrary.org/obo/MP_0002264 abnormal bronchus morphology any structural anomaly of the conducting airway leading to the left lobe of the lungs http://purl.obolibrary.org/obo/MP_0002266 abnormal right major bronchus morphology http://purl.obolibrary.org/obo/MP_0002264 abnormal bronchus morphology any structural anomaly of the conducting airway leading to the right lobe of the lungs http://purl.obolibrary.org/obo/MP_0002267 abnormal bronchiole morphology http://purl.obolibrary.org/obo/MP_0004391 abnormal respiratory conducting tube morphology any structural anomaly of the conducting airway of the lungs found terminal to the bronchi; these structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching http://purl.obolibrary.org/obo/MP_0002268 abnormal terminal bronchiole morphology http://purl.obolibrary.org/obo/MP_0002267 abnormal bronchiole morphology any structural anomaly of the last conducting structure of non-respiratory bronchioles; after this point, the airways have alveoli in their walls http://purl.obolibrary.org/obo/MP_0002269 muscular atrophy http://purl.obolibrary.org/obo/MP_0002108 abnormal muscle morphology acquired diminution of muscle tissue associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes; occurs with age, immobilization, weightlessness, malnutrition or denervation http://purl.obolibrary.org/obo/MP_0002270 abnormal pulmonary alveolus morphology http://purl.obolibrary.org/obo/MP_0010911 abnormal pulmonary acinus morphology any structural anomaly of the small sac-like dilations of the distal airspace of the lung; they are present along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles; gas exchange of oxygen and carbon dioxide between alveolar air and blood in the pulmonary capillaries takes place across the cell walls http://purl.obolibrary.org/obo/MP_0002271 abnormal pulmonary alveolar duct morphology http://purl.obolibrary.org/obo/MP_0010911 abnormal pulmonary acinus morphology any structural anomaly of the respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli http://purl.obolibrary.org/obo/MP_0002272 abnormal nervous system electrophysiology http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology any functional anomaly of the nervous system as it relates to conduction of electrical impulses http://purl.obolibrary.org/obo/MP_0002273 abnormal pulmonary alveolus epithelial cell morphology http://purl.obolibrary.org/obo/MP_0010901 abnormal pulmonary alveolar parenchyma morphology any structural anomaly of the cells lining the alveoli http://purl.obolibrary.org/obo/MP_0002274 abnormal type I pneumocyte morphology http://purl.obolibrary.org/obo/MP_0002273 abnormal pulmonary alveolus epithelial cell morphology any structural anomaly of the flattened, branched squamous cells that covers more than 98 percent of the alveolar surface, and have thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange http://purl.obolibrary.org/obo/MP_0002275 abnormal type II pneumocyte morphology http://purl.obolibrary.org/obo/MP_0002273 abnormal pulmonary alveolus epithelial cell morphology any structural anomaly of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored http://purl.obolibrary.org/obo/MP_0002276 abnormal lung interstitium morphology http://purl.obolibrary.org/obo/MP_0001175 abnormal lung morphology any structural anomaly of the connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin; it functions in the mechanical behavior of the lung, and forms a barrier to regulate the flow of plasma constituents from the capillaries to the airway and alveolar spaces http://purl.obolibrary.org/obo/MP_0002277 abnormal respiratory mucosa morphology http://purl.obolibrary.org/obo/MP_0010942 abnormal respiratory epithelium morphology any structural anomaly of the mucous membrane lining the respiratory tract http://purl.obolibrary.org/obo/MP_0002279 abnormal diaphragm morphology http://purl.obolibrary.org/obo/MP_0003358 abnormal hypaxial muscle morphology any structural anomaly of the thin musculomebranous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control http://purl.obolibrary.org/obo/MP_0002280 abnormal intercostal muscle morphology http://purl.obolibrary.org/obo/MP_0003358 abnormal hypaxial muscle morphology any structural anomaly of the respiratory muscles that arise from the lower border of one rib and insert into the upper border of the adjoining rib http://purl.obolibrary.org/obo/MP_0002281 abnormal respiratory mucosa goblet cell morphology http://purl.obolibrary.org/obo/MP_0002277 abnormal respiratory mucosa morphology any structural anomaly of the cells of the respiratory epithelial lining that produce and secrete mucins http://purl.obolibrary.org/obo/MP_0002282 abnormal trachea morphology http://purl.obolibrary.org/obo/MP_0002132 abnormal respiratory system morphology any structural anomaly of the tube descending from the larynx and branching into the right and left main bronchi http://purl.obolibrary.org/obo/MP_0002284 abnormal tracheal smooth muscle morphology http://purl.obolibrary.org/obo/MP_0002282 abnormal trachea morphology any structural anomaly of the smooth muscle lining the trachea http://purl.obolibrary.org/obo/MP_0002285 abnormal tracheal ciliated epithelium morphology http://purl.obolibrary.org/obo/MP_0010942 abnormal respiratory epithelium morphology any structural anomaly of the epithelial lining of the trachea which contains numerous ciliated cells http://purl.obolibrary.org/obo/MP_0002286 cryptorchism http://purl.obolibrary.org/obo/MP_0001146 abnormal testis morphology failure of one or both of the testes to descend into the scrotum around the time of birth http://purl.obolibrary.org/obo/MP_0002292 abnormal gestational length http://purl.obolibrary.org/obo/MP_0003699 abnormal female reproductive system physiology anomaly in the usual duration of time between when a fertilized egg implants in the wall of the uterus and the birth of offspring http://purl.obolibrary.org/obo/MP_0002293 long gestation period http://purl.obolibrary.org/obo/MP_0002292 abnormal gestational length increase in the average duration of a pregnancy http://purl.obolibrary.org/obo/MP_0002294 short gestation period http://purl.obolibrary.org/obo/MP_0002292 abnormal gestational length decrease in the average duration of a pregnancy http://purl.obolibrary.org/obo/MP_0002295 abnormal pulmonary circulation http://purl.obolibrary.org/obo/MP_0002133 abnormal respiratory system physiology any anomaly in the circulation of blood through the lungs http://purl.obolibrary.org/obo/MP_0002296 aspiration http://purl.obolibrary.org/obo/MP_0002314 abnormal respiratory mechanics inspiration into the airways of fluid or any foreign material http://purl.obolibrary.org/obo/MP_0002297 abnormal forced expiratory flow rates http://purl.obolibrary.org/obo/MP_0002327 abnormal respiratory function anomaly in the rates of airflow during forced vital capacity determination http://purl.obolibrary.org/obo/MP_0002304 abnormal total lung capacity http://purl.obolibrary.org/obo/MP_0002314 abnormal respiratory mechanics anomaly in the volume of air contained in the lungs at the end of maximal inspiration http://purl.obolibrary.org/obo/MP_0002306 abnormal functional residual capacity http://purl.obolibrary.org/obo/MP_0001942 abnormal lung volume anomaly in the volume of air remaining in the lungs at the end of a normal expiration http://purl.obolibrary.org/obo/MP_0002308 abnormal residual volume http://purl.obolibrary.org/obo/MP_0001942 abnormal lung volume anomaly in the volume of air remaining in the lungs at the end of maximal expiration http://purl.obolibrary.org/obo/MP_0002309 abnormal vital capacity http://purl.obolibrary.org/obo/MP_0001942 abnormal lung volume anomaly in the amount of air that is exhaled by a maximal expiration following a maximal inspiration http://purl.obolibrary.org/obo/MP_0002310 decreased susceptibility to hepatic steatosis http://purl.obolibrary.org/obo/MP_0000598 abnormal liver morphology less likely than normal to develop hepatic steatosis http://purl.obolibrary.org/obo/MP_0002311 abnormal inspiratory capacity http://purl.obolibrary.org/obo/MP_0001942 abnormal lung volume anomaly in the maximal volume of air that can be inspired after the end of a normal expiration http://purl.obolibrary.org/obo/MP_0002312 abnormal inspiratory reserve volume http://purl.obolibrary.org/obo/MP_0001942 abnormal lung volume anomaly in the extra volume of air that can be inspired with maximal effort after reaching the end of a normal inspiration http://purl.obolibrary.org/obo/MP_0002313 abnormal tidal volume http://purl.obolibrary.org/obo/MP_0001942 abnormal lung volume anomaly in the volume of air inspired or expired during each normal respiratory cycle http://purl.obolibrary.org/obo/MP_0002314 abnormal respiratory mechanics http://purl.obolibrary.org/obo/MP_0001943 abnormal respiration anomaly in the action of the lungs, diaphragm, ribs and chest wall during respiration http://purl.obolibrary.org/obo/MP_0002316 anoxia http://purl.obolibrary.org/obo/MP_0001574 abnormal oxygen level absence or almost complete absence of oxygen from inspired gases, in blood or tissues http://purl.obolibrary.org/obo/MP_0002318 hypercapnia http://purl.obolibrary.org/obo/MP_0003860 abnormal carbon dioxide level elevated concentration of CO2 in the blood, alveoli or other tissues resulting in the increased pressure of this component of body gases http://purl.obolibrary.org/obo/MP_0002319 hyperoxia http://purl.obolibrary.org/obo/MP_0001574 abnormal oxygen level elevated concentration of O2 in the blood, alveoli or other tissues resulting in the increased pressure of this component of body gases http://purl.obolibrary.org/obo/MP_0002320 hyperventilation http://purl.obolibrary.org/obo/MP_0005575 increased pulmonary ventilation a state in which there is a increased amount of air entering the pulmonary alveoli (increased alveolar ventilation), which causes an decrease in arterial carbon dioxide level http://purl.obolibrary.org/obo/MP_0002321 hypoventilation http://purl.obolibrary.org/obo/MP_0005576 decreased pulmonary ventilation a state in which there is a reduced amount of air entering the pulmonary alveoli (decreased alveolar ventilation), which causes an increase in arterial carbon dioxide level http://purl.obolibrary.org/obo/MP_0002322 abnormal respiratory transport http://purl.obolibrary.org/obo/MP_0001943 abnormal respiration anomaly in the process of gas exchange http://purl.obolibrary.org/obo/MP_0002323 decreased susceptibility to hyperlipidemia http://purl.obolibrary.org/obo/MP_0002118 abnormal lipid homeostasis less likely than normal to develop abnormally high levels of circulating lipids http://purl.obolibrary.org/obo/MP_0002324 abnormal alveolocapillary membrane morphology http://purl.obolibrary.org/obo/MP_0010900 abnormal pulmonary interalveolar septum morphology any structural anomaly of the membrane between the capillary blood and alveolar air, comprised of the alveolar epithelium and the capillary epithelium and their adherent basement membranes and epithelial cell cytoplasm http://purl.obolibrary.org/obo/MP_0002325 abnormal pulmonary diffusing capacity http://purl.obolibrary.org/obo/MP_0002336 abnormal pulmonary gas exchange anomaly in the amount of gas taken up by pulmonary capillary blood per minute per unit of average oxygen pressure gradient between alveolar gas and pulmonary capillary blood http://purl.obolibrary.org/obo/MP_0002326 abnormal ventilation-perfusion ratio http://purl.obolibrary.org/obo/MP_0002338 abnormal pulmonary ventilation anomaly in the ratio of alveolar ventilation to simultaneous capillary blood flow in the lung http://purl.obolibrary.org/obo/MP_0002327 abnormal respiratory function http://purl.obolibrary.org/obo/MP_0001943 abnormal respiration anomaly in any measure of the processes involved in respiration http://purl.obolibrary.org/obo/MP_0002328 abnormal airway resistance http://purl.obolibrary.org/obo/MP_0002327 abnormal respiratory function anomaly in the opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow http://purl.obolibrary.org/obo/MP_0002329 abnormal blood gas level http://purl.obolibrary.org/obo/MP_0009642 abnormal blood homeostasis anomaly in the amount of oxygen and carbon dioxide in the blood http://purl.obolibrary.org/obo/MP_0002330 abnormal bronchial provocation http://purl.obolibrary.org/obo/MP_0002327 abnormal respiratory function anomaly in the results of measures of responsiveness to allergens, pharmacological solutions, or control solutions http://purl.obolibrary.org/obo/MP_0002332 abnormal exercise endurance http://purl.obolibrary.org/obo/MP_0005266 abnormal metabolism improved or impaired performance during controlled physical activity http://purl.obolibrary.org/obo/MP_0002333 abnormal lung compliance http://purl.obolibrary.org/obo/MP_0002314 abnormal respiratory mechanics anomaly in the ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure http://purl.obolibrary.org/obo/MP_0002334 abnormal airway responsiveness http://purl.obolibrary.org/obo/MP_0002330 abnormal bronchial provocation anomalous response in bronchial provocation tests http://purl.obolibrary.org/obo/MP_0002335 decreased airway responsiveness http://purl.obolibrary.org/obo/MP_0002334 abnormal airway responsiveness less easily provoked into bronchoconstriction during bronchial provocation testing http://purl.obolibrary.org/obo/MP_0002336 abnormal pulmonary gas exchange http://purl.obolibrary.org/obo/MP_0002322 abnormal respiratory transport anomaly in the exchange of oxygen and carbon dioxide between the alveolar air and pulmonary capillary blood http://purl.obolibrary.org/obo/MP_0002337 abnormal whole-body plethysmography http://purl.obolibrary.org/obo/MP_0001942 abnormal lung volume anomaly in the measurements gathered in a chamber that encloses the body and in which changes in volume are recorded http://purl.obolibrary.org/obo/MP_0002338 abnormal pulmonary ventilation http://purl.obolibrary.org/obo/MP_0002314 abnormal respiratory mechanics anomaly of the respiratory minute volume, or the total volume of gas per minute inspired or expired expressed in liters per minute; refers to the exchange of air between the total respiratory space and the environment http://purl.obolibrary.org/obo/MP_0002339 abnormal lymph node morphology http://purl.obolibrary.org/obo/MP_0002722 abnormal immune system organ morphology any structural anomaly of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue, and is the site where acquired immune responses are launched http://purl.obolibrary.org/obo/MP_0002340 abnormal axillary lymph node morphology http://purl.obolibrary.org/obo/MP_0008463 abnormal peripheral lymph node morphology any structural anomaly of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region http://purl.obolibrary.org/obo/MP_0002342 abnormal lymph node trabecula morphology http://purl.obolibrary.org/obo/MP_0002339 abnormal lymph node morphology any structural anomaly of the membranous processes on the internal surface of the lymph node capsule, consisting of connective tissue and muscle fibers http://purl.obolibrary.org/obo/MP_0002343 abnormal lymph node cortex morphology http://purl.obolibrary.org/obo/MP_0002339 abnormal lymph node morphology any structural anomaly in the outer area of the lymph node that has B and T cell domains http://purl.obolibrary.org/obo/MP_0002344 abnormal lymph node B cell domain morphology http://purl.obolibrary.org/obo/MP_0002343 abnormal lymph node cortex morphology any structural anomaly of the part of the lymph node cortex in which B lymphocytes home to primary follicles to survey follicular dendritic cells (FDCs); antigen stimulated B cells proliferate and differentiate within the follicles forming distinctive germinal centers http://purl.obolibrary.org/obo/MP_0002345 abnormal lymph node primary follicle morphology http://purl.obolibrary.org/obo/MP_0002344 abnormal lymph node B cell domain morphology any structural anomaly of an unstimulated network of follicular dendritic cells and small resting B cells in the lymph node cortex http://purl.obolibrary.org/obo/MP_0002346 abnormal lymph node secondary follicle morphology http://purl.obolibrary.org/obo/MP_0002344 abnormal lymph node B cell domain morphology any structural anomaly of a lymph node primary follicle that has undergone antigenic challenge and is characterized by a ring of concentrically packed B lymphocytes surrounding a germinal center, which contains proliferating B cells, and a mantle area that contains nondividing B cells and some helper T cells with macrophages and follicular dendritic cells interspersed http://purl.obolibrary.org/obo/MP_0002347 abnormal lymph node T cell domain morphology http://purl.obolibrary.org/obo/MP_0002343 abnormal lymph node cortex morphology any structural anomaly of the paracortex and interfollicular cortex of the lymph node in which T lymphocytes home to survey dendritic cells; T lymphocytes proliferate in the paracortex and enlarge it but do not produce structures analogous to germinal centers http://purl.obolibrary.org/obo/MP_0002348 abnormal lymph node medulla morphology http://purl.obolibrary.org/obo/MP_0002339 abnormal lymph node morphology any structural anomaly in the area of the lymph node through which lymph leaves the node; it contains macrophages and antibody-secreting plasma cells http://purl.obolibrary.org/obo/MP_0002349 abnormal afferent lymphatic vessel morphology http://purl.obolibrary.org/obo/MP_0002339 abnormal lymph node morphology any structural anomaly in the lymphatic tubes entering the lymph node http://purl.obolibrary.org/obo/MP_0002350 abnormal efferent lymphatic vessel morphology http://purl.obolibrary.org/obo/MP_0002339 abnormal lymph node morphology any structural anomaly in the lymphatic tube exiting the lymph node http://purl.obolibrary.org/obo/MP_0002351 abnormal cervical lymph node morphology http://purl.obolibrary.org/obo/MP_0008463 abnormal peripheral lymph node morphology any structural anomaly of the lymph nodes found near the neck and shoulders http://purl.obolibrary.org/obo/MP_0002352 abnormal popliteal lymph node morphology http://purl.obolibrary.org/obo/MP_0008463 abnormal peripheral lymph node morphology any structural anomaly of the lymph nodes which drain the legs http://purl.obolibrary.org/obo/MP_0002353 abnormal inguinal lymph node morphology http://purl.obolibrary.org/obo/MP_0008463 abnormal peripheral lymph node morphology any structural anomaly of the lymph nodes located in the groin area http://purl.obolibrary.org/obo/MP_0002354 abnormal spleen trabecular artery morphology http://purl.obolibrary.org/obo/MP_0011655 abnormal systemic artery morphology any structural anomaly of one of the branches of the splenic artery http://purl.obolibrary.org/obo/MP_0002356 abnormal spleen red pulp morphology http://purl.obolibrary.org/obo/MP_0000689 abnormal spleen morphology any structural anomaly of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation http://purl.obolibrary.org/obo/MP_0002357 abnormal spleen white pulp morphology http://purl.obolibrary.org/obo/MP_0000689 abnormal spleen morphology any structural anomaly of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies http://purl.obolibrary.org/obo/MP_0002358 abnormal spleen periarteriolar lymphoid sheath morphology http://purl.obolibrary.org/obo/MP_0002357 abnormal spleen white pulp morphology any structural anomaly of the area of the spleen in which T cells surround the central arteriole http://purl.obolibrary.org/obo/MP_0002359 abnormal spleen germinal center morphology http://purl.obolibrary.org/obo/MP_0008472 abnormal spleen secondary B follicle morphology any structural anomaly of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs http://purl.obolibrary.org/obo/MP_0002360 abnormal spleen B cell corona morphology http://purl.obolibrary.org/obo/MP_0008472 abnormal spleen secondary B follicle morphology any structural anomaly of the area of the spleen secondary B follicle that surrounds the germinal center and harbors the small recirculating B lymphocytes http://purl.obolibrary.org/obo/MP_0002361 abnormal spleen central arteriole morphology http://purl.obolibrary.org/obo/MP_0002357 abnormal spleen white pulp morphology any structural anomaly of the blood vessel surrounded by the periarteriolar lymphoid sheath that connects the trabecular artery to the trabecular vein http://purl.obolibrary.org/obo/MP_0002362 abnormal spleen marginal zone morphology http://purl.obolibrary.org/obo/MP_0002357 abnormal spleen white pulp morphology any structural anomaly of the zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens http://purl.obolibrary.org/obo/MP_0002363 abnormal spleen marginal sinus morphology http://purl.obolibrary.org/obo/MP_0002357 abnormal spleen white pulp morphology any structural anomaly of the border region surrounding the spleen B cell follicles and the periarteriolar lymphoid sheath (PALS) that separates it from the marginal zone that mediates lymphocyte entry into the white pulp from the blood http://purl.obolibrary.org/obo/MP_0002364 abnormal thymus size http://purl.obolibrary.org/obo/MP_0002221 abnormal lymph organ size deviation from the normal size of the thymus http://purl.obolibrary.org/obo/MP_0002367 abnormal thymus lobule morphology http://purl.obolibrary.org/obo/MP_0000703 abnormal thymus morphology any structural anomaly of the basic structural unit of the thymus http://purl.obolibrary.org/obo/MP_0002368 abnormal thymus capsule morphology http://purl.obolibrary.org/obo/MP_0000703 abnormal thymus morphology any structural anomaly of the fibrous connective tissue surrounding the thymus http://purl.obolibrary.org/obo/MP_0002369 abnormal thymus subcapsular epithelium morphology http://purl.obolibrary.org/obo/MP_0009544 abnormal thymus epithelium morphology any structural anomaly of the epithelial cells lining the capsule and trabeculae of the thymus http://purl.obolibrary.org/obo/MP_0002370 abnormal thymus trabecula morphology http://purl.obolibrary.org/obo/MP_0000703 abnormal thymus morphology any structural anomaly of the thymic connective tissue which extends into the parenchyma http://purl.obolibrary.org/obo/MP_0002371 abnormal thymus cortex morphology http://purl.obolibrary.org/obo/MP_0002367 abnormal thymus lobule morphology any structural anomaly of the outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes http://purl.obolibrary.org/obo/MP_0002375 abnormal thymus medulla morphology http://purl.obolibrary.org/obo/MP_0002367 abnormal thymus lobule morphology any structural anomaly of the inner area of thymus lobules http://purl.obolibrary.org/obo/MP_0002376 abnormal dendritic cell physiology http://purl.obolibrary.org/obo/MP_0002452 abnormal professional antigen presenting cell physiology any functional anomaly of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity http://purl.obolibrary.org/obo/MP_0002377 abnormal mucosa-associated lymphoid tissue morphology http://purl.obolibrary.org/obo/MP_0002722 abnormal immune system organ morphology any structural anomaly of the regional immune system associated with the mucosa http://purl.obolibrary.org/obo/MP_0002378 abnormal gut-associated lymphoid tissue morphology http://purl.obolibrary.org/obo/MP_0002722 abnormal immune system organ morphology any structural anomaly of the regional immune system located in the gut http://purl.obolibrary.org/obo/MP_0002379 abnormal oropharyngeal lymphoid tissue morphology http://purl.obolibrary.org/obo/MP_0002377 abnormal mucosa-associated lymphoid tissue morphology any structural anomaly of the circular lymphoid tissue formed by the lingual, pharyngeal, and facial tonsils http://purl.obolibrary.org/obo/MP_0002380 abnormal palatine tonsil morphology http://purl.obolibrary.org/obo/MP_0002379 abnormal oropharyngeal lymphoid tissue morphology any structural anomaly of either of the two small almond-shaped masses of lymph tissue found on either side of the oropharynx http://purl.obolibrary.org/obo/MP_0002384 abnormal nasopharyngeal tonsil morphology http://purl.obolibrary.org/obo/MP_0002379 abnormal oropharyngeal lymphoid tissue morphology any structural anomaly of the lymph tissue in the roof and posterior wall of the nasopharynx http://purl.obolibrary.org/obo/MP_0002385 abnormal lingual tonsillar tissue morphology http://purl.obolibrary.org/obo/MP_0002379 abnormal oropharyngeal lymphoid tissue morphology any structural anomaly of the lymph tissue on the floor of the oropharyngeal passage, near the root of the tongue http://purl.obolibrary.org/obo/MP_0002386 abnormal tubal tonsil morphology http://purl.obolibrary.org/obo/MP_0002379 abnormal oropharyngeal lymphoid tissue morphology any structural anomaly of the lymph tissue associated with the pharyngeal opening of the auditory tube http://purl.obolibrary.org/obo/MP_0002388 abnormal Peyer's patch epithelium morphology http://purl.obolibrary.org/obo/MP_0000696 abnormal Peyer's patch morphology any structural anomaly of the specialized epithelium of the Peyer's patch http://purl.obolibrary.org/obo/MP_0002389 abnormal Peyer's patch follicle morphology http://purl.obolibrary.org/obo/MP_0000696 abnormal Peyer's patch morphology any structural anomaly of the area of the Peyer's patch normally occupied by B cells http://purl.obolibrary.org/obo/MP_0002391 abnormal Peyer's patch germinal center morphology http://purl.obolibrary.org/obo/MP_0002389 abnormal Peyer's patch follicle morphology any structural anomaly of the area of the Peyer's patch where B cells proliferate and differentiate into plasma cells http://purl.obolibrary.org/obo/MP_0002392 abnormal Peyer's patch T cell area morphology http://purl.obolibrary.org/obo/MP_0002389 abnormal Peyer's patch follicle morphology any structural anomaly of the Peyer's patch area normally occupied by T lymphocytes http://purl.obolibrary.org/obo/MP_0002393 abnormal bronchus-associated lymphoid tissue morphology http://purl.obolibrary.org/obo/MP_0002722 abnormal immune system organ morphology any structural anomaly of the regional immune system located near the bronchus http://purl.obolibrary.org/obo/MP_0002396 abnormal hematopoietic system morphology/development http://purl.obolibrary.org/obo/MP_0005397 hematopoietic system phenotype any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells http://purl.obolibrary.org/obo/MP_0002397 abnormal bone marrow morphology http://purl.obolibrary.org/obo/MP_0003795 abnormal bone structure any structural anomaly of the soft tissue that fills the cavities of bones http://purl.obolibrary.org/obo/MP_0002398 abnormal bone marrow cell morphology/development http://purl.obolibrary.org/obo/MP_0002396 abnormal hematopoietic system morphology/development any structural anomaly of the cells found in the bone marrow http://purl.obolibrary.org/obo/MP_0002399 abnormal pluripotent precursor cell morphology/development http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology any structural anomaly of the cells that give rise to most types of cells necessary for fetal development http://purl.obolibrary.org/obo/MP_0002400 abnormal multipotent stem cell morphology http://purl.obolibrary.org/obo/MP_0002399 abnormal pluripotent precursor cell morphology/development any structural anomaly of the specialized cells that are committed to giving rise to cells with particular functions http://purl.obolibrary.org/obo/MP_0002401 abnormal lymphopoiesis http://purl.obolibrary.org/obo/MP_0005460 abnormal leukopoiesis atypical formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate http://purl.obolibrary.org/obo/MP_0002403 abnormal pre-B cell morphology http://purl.obolibrary.org/obo/MP_0004939 abnormal B cell morphology any structural anomaly of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface http://purl.obolibrary.org/obo/MP_0002404 increased intestinal adenoma incidence http://purl.obolibrary.org/obo/MP_0010383 increased adenoma incidence greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the small and/or large intestine, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0002405 respiratory system inflammation http://purl.obolibrary.org/obo/MP_0002133 abnormal respiratory system physiology local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system http://purl.obolibrary.org/obo/MP_0002406 increased susceptibility to infection http://purl.obolibrary.org/obo/MP_0001793 altered susceptibility to infection greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens http://purl.obolibrary.org/obo/MP_0002407 abnormal double-negative T cell morphology http://purl.obolibrary.org/obo/MP_0002145 abnormal T cell differentiation any structural anomaly of the subset of T cells found in the thymus that express neither CD4 nor CD8 http://purl.obolibrary.org/obo/MP_0002408 abnormal double-positive T cell morphology http://purl.obolibrary.org/obo/MP_0002145 abnormal T cell differentiation any anomaly of the subset of T cells found in the thymus that express both CD4 and CD8 http://purl.obolibrary.org/obo/MP_0002409 decreased susceptibility to infection http://purl.obolibrary.org/obo/MP_0001793 altered susceptibility to infection reduced likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens http://purl.obolibrary.org/obo/MP_0002410 decreased susceptibility to viral infection http://purl.obolibrary.org/obo/MP_0020185 altered susceptibility to viral infection reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus http://purl.obolibrary.org/obo/MP_0002411 decreased susceptibility to bacterial infection http://purl.obolibrary.org/obo/MP_0020186 altered susceptibility to bacterial infection reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria http://purl.obolibrary.org/obo/MP_0002412 increased susceptibility to bacterial infection http://purl.obolibrary.org/obo/MP_0020186 altered susceptibility to bacterial infection greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria http://purl.obolibrary.org/obo/MP_0002413 abnormal megakaryocyte progenitor cell morphology http://purl.obolibrary.org/obo/MP_0002398 abnormal bone marrow cell morphology/development any structural anomaly of the progenitor cells of the thrombocytic (platelet) line of cells http://purl.obolibrary.org/obo/MP_0002414 abnormal myeloblast morphology/development http://purl.obolibrary.org/obo/MP_0002398 abnormal bone marrow cell morphology/development any structural anomaly of the cells found in the bone marrow that give rise to the granulocyte line of blood cells http://purl.obolibrary.org/obo/MP_0002415 abnormal neutrophil differentiation http://purl.obolibrary.org/obo/MP_0008111 abnormal granulocyte differentiation atypical production of or inability to produce the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes http://purl.obolibrary.org/obo/MP_0002416 abnormal proerythroblast morphology http://purl.obolibrary.org/obo/MP_0002398 abnormal bone marrow cell morphology/development any structural anomaly of the immature, nucleated erythrocyte precursors that give rise to reticulocytes and are derived from erythroid progenitor cells http://purl.obolibrary.org/obo/MP_0002417 abnormal megakaryocyte morphology http://purl.obolibrary.org/obo/MP_0002413 abnormal megakaryocyte progenitor cell morphology any structural anomaly of a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm http://purl.obolibrary.org/obo/MP_0002418 increased susceptibility to viral infection http://purl.obolibrary.org/obo/MP_0020185 altered susceptibility to viral infection greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus http://purl.obolibrary.org/obo/MP_0002419 abnormal innate immunity http://purl.obolibrary.org/obo/MP_0001790 abnormal immune system physiology anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens http://purl.obolibrary.org/obo/MP_0002420 abnormal adaptive immunity http://purl.obolibrary.org/obo/MP_0001790 abnormal immune system physiology anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory http://purl.obolibrary.org/obo/MP_0002421 abnormal cell-mediated immunity http://purl.obolibrary.org/obo/MP_0001790 abnormal immune system physiology abnormal function of any adaptive immune response in which T cells play a main role http://purl.obolibrary.org/obo/MP_0002422 abnormal basophil morphology http://purl.obolibrary.org/obo/MP_0002441 abnormal granulocyte morphology any structural anomaly of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size; these cells contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation http://purl.obolibrary.org/obo/MP_0002423 abnormal mast cell physiology http://purl.obolibrary.org/obo/MP_0002462 abnormal granulocyte physiology any functional anomaly of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules http://purl.obolibrary.org/obo/MP_0002424 abnormal reticulocyte morphology http://purl.obolibrary.org/obo/MP_0000245 abnormal erythropoiesis any structural anomaly of immature erythrocytes characterized by a meshlike pattern of threads and particles at the former site of the nucleus http://purl.obolibrary.org/obo/MP_0002425 altered susceptibility to autoimmune disorder http://purl.obolibrary.org/obo/MP_0001844 autoimmune response a change in the likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides http://purl.obolibrary.org/obo/MP_0002427 disproportionate dwarf http://purl.obolibrary.org/obo/MP_0001265 decreased body size abnormally undersized with disproportionate body parts; usually with more significant shortening of the limbs in proportion to the trunk size http://purl.obolibrary.org/obo/MP_0002428 abnormal semicircular canal morphology http://purl.obolibrary.org/obo/MP_0002729 abnormal inner ear canal morphology any structural anomaly of the organ of balance composed of three long bony tubes of the labyrinth http://purl.obolibrary.org/obo/MP_0002429 abnormal blood cell morphology/development http://purl.obolibrary.org/obo/MP_0002396 abnormal hematopoietic system morphology/development any structural anomaly of any of the cells found in the blood or hematopoietic organ http://purl.obolibrary.org/obo/MP_0002432 abnormal CD4-positive, alpha beta T cell morphology http://purl.obolibrary.org/obo/MP_0002435 abnormal effector T cell morphology any structural anomaly of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production http://purl.obolibrary.org/obo/MP_0002433 abnormal T-helper 1 cell morphology http://purl.obolibrary.org/obo/MP_0010183 abnormal CD4-positive helper T cell morphology any structural anomaly of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity http://purl.obolibrary.org/obo/MP_0002434 abnormal T-helper 2 cell morphology http://purl.obolibrary.org/obo/MP_0010183 abnormal CD4-positive helper T cell morphology any structural anomaly of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy http://purl.obolibrary.org/obo/MP_0002435 abnormal effector T cell morphology http://purl.obolibrary.org/obo/MP_0008037 abnormal T cell morphology any structural anomaly of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell http://purl.obolibrary.org/obo/MP_0002436 abnormal CD8-positive, alpha-beta cytotoxic T cell morphology http://purl.obolibrary.org/obo/MP_0012762 abnormal alpha-beta T cell morphology any structural anomaly of a CD8-positive, alpha-beta T cell capable of killing target cells in an antigen specific manner http://purl.obolibrary.org/obo/MP_0002439 abnormal plasma cell morphology http://purl.obolibrary.org/obo/MP_0004939 abnormal B cell morphology any structural anomaly of a terminally differentiated, post-mitotic, short-lived cell of the B cell lineage devoted to producing large amounts of immunoglobulin http://purl.obolibrary.org/obo/MP_0002440 abnormal memory B cell morphology http://purl.obolibrary.org/obo/MP_0008171 abnormal mature B cell morphology any structural anomaly of a distinctly differentiated long-lived B cell that is readily activated upon reencounter of its antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin http://purl.obolibrary.org/obo/MP_0002441 abnormal granulocyte morphology http://purl.obolibrary.org/obo/MP_0008250 abnormal myeloid leukocyte morphology any structural anomaly of leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils http://purl.obolibrary.org/obo/MP_0002442 abnormal leukocyte physiology http://purl.obolibrary.org/obo/MP_0012382 abnormal blood cell physiology any functional anomaly of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) http://purl.obolibrary.org/obo/MP_0002443 abnormal eosinophil differentiation http://purl.obolibrary.org/obo/MP_0008111 abnormal granulocyte differentiation atypical production of or inability to produce the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin and is involved in clearance of parasitic infections and in allergic reactions http://purl.obolibrary.org/obo/MP_0002444 abnormal T cell physiology http://purl.obolibrary.org/obo/MP_0003945 abnormal lymphocyte physiology any functional anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation http://purl.obolibrary.org/obo/MP_0002445 abnormal mononuclear cell differentiation http://purl.obolibrary.org/obo/MP_0005460 abnormal leukopoiesis atypical production of or inability to produce a leukocyte with a single non-segmented nucleus in the mature form http://purl.obolibrary.org/obo/MP_0002446 abnormal macrophage morphology http://purl.obolibrary.org/obo/MP_0008248 abnormal mononuclear phagocyte morphology any structural anomaly of the large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology http://purl.obolibrary.org/obo/MP_0000245 abnormal erythropoiesis any structural anomaly of a mature red blood cell, an ennucleate biconcave disk about 7 micrometers in diameter that contains hemoglobin confined within a lipid membrane; it is the major cellular element of the circulating blood and transports oxygen as its principal function http://purl.obolibrary.org/obo/MP_0002450 abnormal lymph organ development http://purl.obolibrary.org/obo/MP_0002722 abnormal immune system organ morphology anomaly in the process of morphological maturation of the organs of the lymph system http://purl.obolibrary.org/obo/MP_0002451 abnormal macrophage physiology http://purl.obolibrary.org/obo/MP_0002452 abnormal professional antigen presenting cell physiology any functional anomaly of the large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells http://purl.obolibrary.org/obo/MP_0002452 abnormal professional antigen presenting cell physiology http://purl.obolibrary.org/obo/MP_0002421 abnormal cell-mediated immunity any functional anomaly of a cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response http://purl.obolibrary.org/obo/MP_0002453 abnormal B lymphocyte antigen presentation http://purl.obolibrary.org/obo/MP_0002459 abnormal B cell physiology anomaly in the ability of B lymphocyte to process and/or present antigen http://purl.obolibrary.org/obo/MP_0002454 abnormal macrophage antigen presentation http://purl.obolibrary.org/obo/MP_0002451 abnormal macrophage physiology anomaly in the ability of macrophage phagocytic cells to process and present antigen to T lymphocytes http://purl.obolibrary.org/obo/MP_0002455 abnormal dendritic cell antigen presentation http://purl.obolibrary.org/obo/MP_0002376 abnormal dendritic cell physiology anomaly in the ability of dendritic cells to process and present antigen to T lymphocytes http://purl.obolibrary.org/obo/MP_0002456 abnormal Langerhans cell antigen presentation http://purl.obolibrary.org/obo/MP_0005362 abnormal Langerhans cell physiology anomaly in the ability of phagocytic cells of the epidermis to display antigen for recognition by T lymphocytes http://purl.obolibrary.org/obo/MP_0002458 abnormal B cell number http://purl.obolibrary.org/obo/MP_0004939 abnormal B cell morphology deviation from the normal count of cells that are formed in the bone marrow, migrate to the peripheral lymphatic system, and mature into plasma cells or memory cells; these cells are involved in humoral immunity http://purl.obolibrary.org/obo/MP_0002459 abnormal B cell physiology http://purl.obolibrary.org/obo/MP_0003945 abnormal lymphocyte physiology any functional anomaly of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens http://purl.obolibrary.org/obo/MP_0002460 decreased immunoglobulin level http://purl.obolibrary.org/obo/MP_0002490 abnormal immunoglobulin level less than normal immunoglobulin level http://purl.obolibrary.org/obo/MP_0002461 increased immunoglobulin level http://purl.obolibrary.org/obo/MP_0002490 abnormal immunoglobulin level greater than normal immunoglobulin level http://purl.obolibrary.org/obo/MP_0002462 abnormal granulocyte physiology http://purl.obolibrary.org/obo/MP_0002442 abnormal leukocyte physiology any functional anomaly of neutrophils, eosinophils, or basophils http://purl.obolibrary.org/obo/MP_0002463 abnormal neutrophil physiology http://purl.obolibrary.org/obo/MP_0002462 abnormal granulocyte physiology abnormal function of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes http://purl.obolibrary.org/obo/MP_0002464 abnormal basophil physiology http://purl.obolibrary.org/obo/MP_0002462 abnormal granulocyte physiology any functional anomaly of the leukocyte that contains granules that stain with basic dyes http://purl.obolibrary.org/obo/MP_0002465 abnormal eosinophil physiology http://purl.obolibrary.org/obo/MP_0002462 abnormal granulocyte physiology any functional anomaly of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin and is involved in clearance of parasitic infections and in allergic reactions http://purl.obolibrary.org/obo/MP_0002467 impaired neutrophil phagocytosis http://purl.obolibrary.org/obo/MP_0002463 abnormal neutrophil physiology reduced ability of neutrophils to internalize particulate matter http://purl.obolibrary.org/obo/MP_0002471 abnormal complement pathway http://purl.obolibrary.org/obo/MP_0002419 abnormal innate immunity impaired ability of the complement proteins to act sequentially to directly kill microbes, dispose of immune complexes, and regulate other immune processes http://purl.obolibrary.org/obo/MP_0002472 impaired complement alternative pathway http://purl.obolibrary.org/obo/MP_0002471 abnormal complement pathway abnormal function of the plasma protein cascade triggered by direct contact with pathogen surfaces http://purl.obolibrary.org/obo/MP_0002473 impaired complement classical pathway http://purl.obolibrary.org/obo/MP_0002471 abnormal complement pathway abnormal function of the plasma protein cascade triggered by antigen:antibody complexes http://purl.obolibrary.org/obo/MP_0002490 abnormal immunoglobulin level http://purl.obolibrary.org/obo/MP_0002723 abnormal immune serum protein physiology deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies http://purl.obolibrary.org/obo/MP_0002491 decreased IgD level http://purl.obolibrary.org/obo/MP_0020172 abnormal IgD level less than normal immunoglobulin class D level http://purl.obolibrary.org/obo/MP_0002492 decreased IgE level http://purl.obolibrary.org/obo/MP_0020173 abnormal IgE level less than normal immunoglobulin class E level http://purl.obolibrary.org/obo/MP_0002493 increased IgG level http://purl.obolibrary.org/obo/MP_0020174 abnormal IgG level greater than normal immunoglobulin class G level http://purl.obolibrary.org/obo/MP_0002494 increased IgM level http://purl.obolibrary.org/obo/MP_0020180 abnormal IgM level greater than normal immunoglobulin class M level http://purl.obolibrary.org/obo/MP_0002495 increased IgA level http://purl.obolibrary.org/obo/MP_0020171 abnormal IgA level greater than normal immunoglobulin class A level http://purl.obolibrary.org/obo/MP_0002496 increased IgD level http://purl.obolibrary.org/obo/MP_0020172 abnormal IgD level greater than normal immunoglobulin class D level http://purl.obolibrary.org/obo/MP_0002497 increased IgE level http://purl.obolibrary.org/obo/MP_0020173 abnormal IgE level greater than normal immunoglobulin class E level http://purl.obolibrary.org/obo/MP_0002498 abnormal acute inflammation http://purl.obolibrary.org/obo/MP_0001845 abnormal inflammatory response aberrant early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response http://purl.obolibrary.org/obo/MP_0002499 chronic inflammation http://purl.obolibrary.org/obo/MP_0001845 abnormal inflammatory response persistent inflammatory response, often caused by persistent infection or during an autoimmune response http://purl.obolibrary.org/obo/MP_0002500 granulomatous inflammation http://purl.obolibrary.org/obo/MP_0002499 chronic inflammation chronic inflammation resulting from the failure of the acute inflammatory response and persistence of the injurious agent; characterized by a central area of macrophages, often fused into giant cells, and surrounded by T cells http://purl.obolibrary.org/obo/MP_0002503 abnormal histamine physiology http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis any functional anomaly of this amine that is involved in local immune response, in regulating physiological function in the gut, and that acts as a neurotransmitter http://purl.obolibrary.org/obo/MP_0002531 abnormal type I hypersensitivity reaction http://purl.obolibrary.org/obo/MP_0002498 abnormal acute inflammation anomaly in a reaction manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks http://purl.obolibrary.org/obo/MP_0002532 abnormal type II hypersensitivity reaction http://purl.obolibrary.org/obo/MP_0002498 abnormal acute inflammation anomaly in the response caused by an Ag-Ab reaction; antibodies are directly or indirectly cytotoxic to antigens on cell surfaces or in connective tissues; most often involves IgG and IgM; complement activation is usually involved http://purl.obolibrary.org/obo/MP_0002533 abnormal type III hypersensitivity reaction http://purl.obolibrary.org/obo/MP_0002498 abnormal acute inflammation anomaly in the tissue injury mediated by immune complexes; generally involves immune complexes formed in the blood via Abs encountering circulating Ag-Ab complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury http://purl.obolibrary.org/obo/MP_0002534 abnormal type IV hypersensitivity reaction http://purl.obolibrary.org/obo/MP_0002498 abnormal acute inflammation anomaly in an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact http://purl.obolibrary.org/obo/MP_0002543 brachyphalangia http://purl.obolibrary.org/obo/MP_0005306 abnormal phalanx morphology abnormally short phalanges http://purl.obolibrary.org/obo/MP_0002544 brachydactyly http://purl.obolibrary.org/obo/MP_0002110 abnormal digit morphology abnormally short digits http://purl.obolibrary.org/obo/MP_0002546 mydriasis http://purl.obolibrary.org/obo/MP_0001317 abnormal pupil morphology increased diameter of one or both central circular aperture of the iris through which light rays enter the eye http://purl.obolibrary.org/obo/MP_0002551 abnormal blood coagulation http://purl.obolibrary.org/obo/MP_0009676 abnormal hemostasis altered ability or inability of the blood to clot http://purl.obolibrary.org/obo/MP_0002553 preference for addictive substance http://purl.obolibrary.org/obo/MP_0009745 abnormal behavioral response to xenobiotic strong predilection for an addictive substance http://purl.obolibrary.org/obo/MP_0002554 aversion to addictive substance http://purl.obolibrary.org/obo/MP_0009745 abnormal behavioral response to xenobiotic purposeful avoidance of an addictive substance due to dislike http://purl.obolibrary.org/obo/MP_0002555 addiction http://purl.obolibrary.org/obo/MP_0002553 preference for addictive substance strong dependence on an addictive compound such as alcohol or narcotics that results in uncontrollable cravings for such compounds http://purl.obolibrary.org/obo/MP_0002556 abnormal cocaine consumption http://purl.obolibrary.org/obo/MP_0009745 abnormal behavioral response to xenobiotic aberrant behavioral-related or physiological-related intake of cocaine into the body http://purl.obolibrary.org/obo/MP_0002557 abnormal social/conspecific interaction http://purl.obolibrary.org/obo/MP_0004924 abnormal behavior deviation of the normal behavior of animals towards each other http://purl.obolibrary.org/obo/MP_0002558 abnormal circadian period http://purl.obolibrary.org/obo/MP_0001502 abnormal circadian rhythm any change in the cycle length expressed when exposed to constant conditions without temporal cues http://purl.obolibrary.org/obo/MP_0002559 abnormal circadian persistence http://purl.obolibrary.org/obo/MP_0001502 abnormal circadian rhythm anomaly in the ability for an animal to retain a circadian rhythm when time cues are removed http://purl.obolibrary.org/obo/MP_0002560 arrhythmic circadian persistence http://purl.obolibrary.org/obo/MP_0002559 abnormal circadian persistence loss of any rhythmic pattern upon removal of time cues http://purl.obolibrary.org/obo/MP_0002561 abnormal circadian phase http://purl.obolibrary.org/obo/MP_0001502 abnormal circadian rhythm anomaly in the phase relationship between a temporal synchronizing event (such as light cycle) and a phase reference point of an animal (such as activity onset) http://purl.obolibrary.org/obo/MP_0002562 prolonged circadian period http://purl.obolibrary.org/obo/MP_0002558 abnormal circadian period increase in the cycle length expressed when exposed to constant conditions without temporal cues http://purl.obolibrary.org/obo/MP_0002563 shortened circadian period http://purl.obolibrary.org/obo/MP_0002558 abnormal circadian period decrease in the cycle length expressed when exposed to constant conditions without temporal cues http://purl.obolibrary.org/obo/MP_0002564 advanced circadian phase http://purl.obolibrary.org/obo/MP_0002561 abnormal circadian phase increase in the phase relationship between a temporal synchronizing event (such as light cycle) and a phase reference point of an animal (such as activity onset) http://purl.obolibrary.org/obo/MP_0002565 delayed circadian phase http://purl.obolibrary.org/obo/MP_0002561 abnormal circadian phase decrease in the phase relationship between a temporal synchronizing event (such as light cycle) and a phase reference point of an animal (such as activity onset) http://purl.obolibrary.org/obo/MP_0002566 abnormal sexual interaction http://purl.obolibrary.org/obo/MP_0002557 abnormal social/conspecific interaction altered initiation, failure of initiation or incomplete mating behavior http://purl.obolibrary.org/obo/MP_0002570 alcohol aversion http://purl.obolibrary.org/obo/MP_0002554 aversion to addictive substance purposeful avoidance of alcohol due to dislike http://purl.obolibrary.org/obo/MP_0002571 senility http://purl.obolibrary.org/obo/MP_0002063 abnormal learning/memory/conditioning a degenerative state of brain function manifesting in an impairment of memory, judgment, attention span, problem solving skills, the inability to perform previously learned skills that cannot be attributed to deficits of motor or sensory function, and a global loss of cognitive abilities http://purl.obolibrary.org/obo/MP_0002572 abnormal emotion/affect behavior http://purl.obolibrary.org/obo/MP_0004924 abnormal behavior altered response in tests for emotional related behaviors http://purl.obolibrary.org/obo/MP_0002573 behavioral despair http://purl.obolibrary.org/obo/MP_0003360 abnormal depression-related behavior depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli http://purl.obolibrary.org/obo/MP_0002574 increased vertical activity http://purl.obolibrary.org/obo/MP_0020167 abnormal vertical activity greater than average time spent jumping or rearing http://purl.obolibrary.org/obo/MP_0002575 increased circulating ketone body level http://purl.obolibrary.org/obo/MP_0003457 abnormal circulating ketone body level greater than the normal amount of acetoacetate, 3-hydroxybutyrate (beta-hydroxybutyrate) and/or acteone in the blood, which are produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus http://purl.obolibrary.org/obo/MP_0002576 abnormal enamel morphology http://purl.obolibrary.org/obo/MP_0003930 abnormal tooth hard tissue morphology any structural anomaly of the hard outer coating of the exposed portion of the tooth http://purl.obolibrary.org/obo/MP_0002577 reduced enamel thickness http://purl.obolibrary.org/obo/MP_0002576 abnormal enamel morphology thin hard coating of the exposed portion of the tooth http://purl.obolibrary.org/obo/MP_0002578 impaired ability to fire action potentials http://purl.obolibrary.org/obo/MP_0005402 abnormal action potential anomaly resulting in reduced changes in membrane potentials occurring in nerve or other excitable tissue when excitation occurs http://purl.obolibrary.org/obo/MP_0002579 disorganized secondary lens fibers http://purl.obolibrary.org/obo/MP_0002840 abnormal lens fiber morphology deformation or misalignment of the elongated cells that form the crystalline lens http://purl.obolibrary.org/obo/MP_0002580 duodenal lesions http://purl.obolibrary.org/obo/MP_0003271 abnormal duodenum morphology focal pathological changes characterized by alteration in the size, shape and organization of the cellular components of the duodenum epithelium tissue http://purl.obolibrary.org/obo/MP_0002581 abnormal ileum morphology http://purl.obolibrary.org/obo/MP_0000496 abnormal small intestine morphology any structural anomaly of the portion of the small intestine that extends from the jejunum to the colon http://purl.obolibrary.org/obo/MP_0002582 disorganized extraembryonic tissue http://purl.obolibrary.org/obo/MP_0002086 abnormal extraembryonic tissue morphology a lack of the regular arrangement of the membranes involved with the embryo's protection and nutrition http://purl.obolibrary.org/obo/MP_0002583 absent extraembryonic ectoderm http://purl.obolibrary.org/obo/MP_0010736 abnormal extraembryonic ectoderm morphology absence of the endoderm layer of the extraembryonic tissue http://purl.obolibrary.org/obo/MP_0002584 small ectoplacental cone http://purl.obolibrary.org/obo/MP_0005032 abnormal ectoplacental cone morphology reduced size of the thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta http://purl.obolibrary.org/obo/MP_0002586 abnormal platelet volume http://purl.obolibrary.org/obo/MP_0004720 abnormal platelet morphology anomaly in the content of platelet cells over normal http://purl.obolibrary.org/obo/MP_0002590 increased mean corpuscular volume http://purl.obolibrary.org/obo/MP_0000226 abnormal mean corpuscular volume greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices http://purl.obolibrary.org/obo/MP_0002591 decreased mean corpuscular volume http://purl.obolibrary.org/obo/MP_0000226 abnormal mean corpuscular volume less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices http://purl.obolibrary.org/obo/MP_0002593 high mean erythrocyte cell number http://purl.obolibrary.org/obo/MP_0003131 increased erythrocyte cell number greater than average numbers of red blood cells http://purl.obolibrary.org/obo/MP_0002594 low mean erythrocyte cell number http://purl.obolibrary.org/obo/MP_0002875 decreased erythrocyte cell number less than average numbers of red blood cells http://purl.obolibrary.org/obo/MP_0002596 abnormal hematocrit http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology greater or less than the average percentage of a volume of a blood sample occupied by red blood cells http://purl.obolibrary.org/obo/MP_0002599 increased mean platelet volume http://purl.obolibrary.org/obo/MP_0002586 abnormal platelet volume increased average content of platelet cells over normal http://purl.obolibrary.org/obo/MP_0002602 abnormal eosinophil cell number http://purl.obolibrary.org/obo/MP_0020201 abnormal granulocyte number deviation from the normal numbers of eosinophils http://purl.obolibrary.org/obo/MP_0002606 increased basophil cell number http://purl.obolibrary.org/obo/MP_0012442 abnormal basophil cell number higher than average number of basophils as measured by the percent of the total number of leukocytes http://purl.obolibrary.org/obo/MP_0002607 decreased basophil cell number http://purl.obolibrary.org/obo/MP_0012442 abnormal basophil cell number lower than average number of basophils as measured by the percent of the total number of leukocytes http://purl.obolibrary.org/obo/MP_0002608 increased hematocrit http://purl.obolibrary.org/obo/MP_0002596 abnormal hematocrit greater than average percentage of a volume of a blood sample occupied by red blood cells http://purl.obolibrary.org/obo/MP_0002619 abnormal lymphocyte morphology http://purl.obolibrary.org/obo/MP_0008247 abnormal mononuclear cell morphology any structural anomaly of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells http://purl.obolibrary.org/obo/MP_0002620 abnormal monocyte morphology http://purl.obolibrary.org/obo/MP_0008248 abnormal mononuclear phagocyte morphology any structural anomaly of the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood http://purl.obolibrary.org/obo/MP_0002621 delayed neural tube closure http://purl.obolibrary.org/obo/MP_0003720 abnormal neural tube closure delay in the last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline http://purl.obolibrary.org/obo/MP_0002622 abnormal cochlear hair cell morphology http://purl.obolibrary.org/obo/MP_0003308 abnormal cochlear sensory epithelium morphology any structural anomaly of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve http://purl.obolibrary.org/obo/MP_0002623 abnormal vestibular hair cell morphology http://purl.obolibrary.org/obo/MP_0000045 abnormal hair cell morphology any structural anomaly of the mechanoreceptor cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the internal ear; afferent and efferent nerve fibers of the vestibular nerve end synaptically on them; from the apical end of each cell a bundle of stereocilia and a kinocilium extend into the statoconial membrane of the maculae and the cupula of the cristae http://purl.obolibrary.org/obo/MP_0002624 abnormal tricuspid valve morphology http://purl.obolibrary.org/obo/MP_0002745 abnormal atrioventricular valve morphology any structural anomaly of the valve located between the right atrium and the right ventricle of the heart, and contains three cusps, the anterior cusp (infundibular cusp), the posterior cusp (marginal cusp), and the septal cusp (medial cusp), attached to the outer fibrous ring (anulus) http://purl.obolibrary.org/obo/MP_0002625 heart left ventricle hypertrophy http://purl.obolibrary.org/obo/MP_0010579 increased heart left ventricle size increased size of the left ventricle http://purl.obolibrary.org/obo/MP_0002626 increased heart rate http://purl.obolibrary.org/obo/MP_0001629 abnormal heart rate greater than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute http://purl.obolibrary.org/obo/MP_0002627 increased teratoma incidence http://purl.obolibrary.org/obo/MP_0010273 increased classified tumor incidence higher than normal incidence of generally benign germ cell-derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor; malignant tumors are highly metatstatic http://purl.obolibrary.org/obo/MP_0002628 hepatic steatosis http://purl.obolibrary.org/obo/MP_0000598 abnormal liver morphology an accumulation of fat deposits in the liver http://purl.obolibrary.org/obo/MP_0002629 hyperactivity elicited by ethanol administration http://purl.obolibrary.org/obo/MP_0009751 enhanced behavioral response to alcohol increased activity after ingestion of alcohol http://purl.obolibrary.org/obo/MP_0002630 abnormal endocochlear potential http://purl.obolibrary.org/obo/MP_0006390 abnormal cochlear endolymph any alterations in the electrical potential difference (+80 - 100 mV) between the endolymphatic and perilymphatic compartments of the cochlea; this potential is generated by the stria vascularis http://purl.obolibrary.org/obo/MP_0002631 abnormal epididymis morphology http://purl.obolibrary.org/obo/MP_0009205 abnormal internal male genitalia morphology any structural anomaly of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens http://purl.obolibrary.org/obo/MP_0002632 vestigial tail http://purl.obolibrary.org/obo/MP_0002111 abnormal tail morphology a trace or rudimentary caudal structure, often a short boneless filament; the degenerated remains of any tail structure http://purl.obolibrary.org/obo/MP_0002633 persistent truncus arteriosis http://purl.obolibrary.org/obo/MP_0010651 aorticopulmonary septal defect complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development http://purl.obolibrary.org/obo/MP_0002634 abnormal sensorimotor gating http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology malfunction of the process by which inhibitory neural pathways filter multiple stimuli and allow attention to be focused on one stimulus; usually measured by pre-pulse inhibition (PPI) http://purl.obolibrary.org/obo/MP_0002635 reduced sensorimotor gating http://purl.obolibrary.org/obo/MP_0002634 abnormal sensorimotor gating attenuation of the process by which inhibitory neural pathways filter multiple stimuli and allow attention to be focused on one stimulus; usually measured by pre-pulse inhibition (PPI) http://purl.obolibrary.org/obo/MP_0002636 delayed vaginal opening http://purl.obolibrary.org/obo/MP_0020150 abnormal timing of vaginal opening the opening of the genital canal in a female occurring at a later than expected age http://purl.obolibrary.org/obo/MP_0002637 small uterus http://purl.obolibrary.org/obo/MP_0004902 abnormal uterus size reduced size of the female muscular organ of gestation http://purl.obolibrary.org/obo/MP_0002638 abnormal pupillary reflex http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology alterations or failure of the pupil to change in diameter as a reflex response to any stimulus http://purl.obolibrary.org/obo/MP_0002639 micrognathia http://purl.obolibrary.org/obo/MP_0000454 abnormal jaw morphology abnormally reduced size of the jaws, especially of the mandible http://purl.obolibrary.org/obo/MP_0002640 reticulocytosis http://purl.obolibrary.org/obo/MP_0011913 abnormal reticulocyte cell number an increase in the number of circulating reticulocytes, which is normally less than 1 per cent of the total number of red blood cells http://purl.obolibrary.org/obo/MP_0002641 anisopoikilocytosis http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology presence in blood of RBCs of abnormal shapes and sizes http://purl.obolibrary.org/obo/MP_0002642 anisocytosis http://purl.obolibrary.org/obo/MP_0010067 increased red blood cell distribution width considerable variation of the size of red blood cells compared to a normal range http://purl.obolibrary.org/obo/MP_0002643 poikilocytosis http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology blood cells of variable shape on smear http://purl.obolibrary.org/obo/MP_0002644 decreased circulating triglyceride level http://purl.obolibrary.org/obo/MP_0011969 abnormal circulating triglyceride level reduced concentration of naturally occurring esters of three fatty acids and glycerol in the blood; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver http://purl.obolibrary.org/obo/MP_0002645 abnormal intestinal cholesterol absorption http://purl.obolibrary.org/obo/MP_0005342 abnormal intestinal lipid absorption any anomaly in the ability of the body to take up cholesterol into the blood by absorption from the small intestine http://purl.obolibrary.org/obo/MP_0002646 increased intestinal cholesterol absorption http://purl.obolibrary.org/obo/MP_0002645 abnormal intestinal cholesterol absorption augmented ability of the body to take up cholesterol into the blood by absorption from the small intestine http://purl.obolibrary.org/obo/MP_0002647 decreased intestinal cholesterol absorption http://purl.obolibrary.org/obo/MP_0002645 abnormal intestinal cholesterol absorption reduced ability of the body to take up cholesterol into the blood by absorption from the small intestine http://purl.obolibrary.org/obo/MP_0002648 delaminated enamel http://purl.obolibrary.org/obo/MP_0002576 abnormal enamel morphology separation of the hard outer coating of the exposed portion of the tooth from the underlying hard tissue http://purl.obolibrary.org/obo/MP_0002649 abnormal enamel rod pattern http://purl.obolibrary.org/obo/MP_0002576 abnormal enamel morphology any anomaly in the orientation of the structural unit of tooth enamel http://purl.obolibrary.org/obo/MP_0002650 abnormal ameloblast morphology http://purl.obolibrary.org/obo/MP_0000116 abnormal tooth development any structural anomaly of the epithelial cells of the inner layer of the enamel organ of the developing tooth http://purl.obolibrary.org/obo/MP_0002651 abnormal sciatic nerve morphology http://purl.obolibrary.org/obo/MP_0001077 abnormal spinal nerve morphology any structural anomaly of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity http://purl.obolibrary.org/obo/MP_0002652 thin myocardium http://purl.obolibrary.org/obo/MP_0005329 abnormal myocardium layer morphology reduced thickness of the cardiac muscle layer http://purl.obolibrary.org/obo/MP_0002653 abnormal ependyma morphology http://purl.obolibrary.org/obo/MP_0003632 abnormal nervous system morphology any structural anomaly of the cellular membrane that lines the brain ventricles and the central canal of the spinal cord http://purl.obolibrary.org/obo/MP_0002654 spongiform encephalopathy http://purl.obolibrary.org/obo/MP_0002229 neurodegeneration a neurodegenerative state characterized by the appearance of large vacuolated areas in the brain cells, resembling a sponge http://purl.obolibrary.org/obo/MP_0002655 abnormal keratinocyte morphology http://purl.obolibrary.org/obo/MP_0001216 abnormal epidermal layer morphology any structural anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum http://purl.obolibrary.org/obo/MP_0002656 abnormal keratinocyte differentiation http://purl.obolibrary.org/obo/MP_0005076 abnormal cell differentiation developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum http://purl.obolibrary.org/obo/MP_0002657 chondrodystrophy http://purl.obolibrary.org/obo/MP_0002113 abnormal skeleton development abnormal development of the cartilage primordia of long bones, resulting in abnormally short extremities but normal head and trunk http://purl.obolibrary.org/obo/MP_0002658 abnormal liver regeneration http://purl.obolibrary.org/obo/MP_0000609 abnormal liver physiology deviation from the normal ability of liver to regenerate healthy tissue following partial hepatectomy http://purl.obolibrary.org/obo/MP_0002659 pituitary gland hypoplasia http://purl.obolibrary.org/obo/MP_0005361 small pituitary gland underdevelopment or reduced size, usually due to a reduced number of cells, of the pituitary gland http://purl.obolibrary.org/obo/MP_0002660 abnormal caput epididymis morphology http://purl.obolibrary.org/obo/MP_0002631 abnormal epididymis morphology any structural anomaly of the head of the epididymis http://purl.obolibrary.org/obo/MP_0002661 abnormal corpus epididymis morphology http://purl.obolibrary.org/obo/MP_0002631 abnormal epididymis morphology any structural anomaly of the body of the epididymis http://purl.obolibrary.org/obo/MP_0002662 abnormal cauda epididymis morphology http://purl.obolibrary.org/obo/MP_0002631 abnormal epididymis morphology any structural anomaly of the tail of the epididymis http://purl.obolibrary.org/obo/MP_0002663 failure to form blastocele http://purl.obolibrary.org/obo/MP_0012129 failure of blastocyst formation developmental anomaly resulting in the absence of the cavity in the blastocyst of the developing embryo http://purl.obolibrary.org/obo/MP_0002664 decreased circulating adrenocorticotropin level http://purl.obolibrary.org/obo/MP_0005128 decreased adrenocorticotropin level decreased concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex http://purl.obolibrary.org/obo/MP_0002665 decreased circulating corticosterone level http://purl.obolibrary.org/obo/MP_0005345 abnormal circulating corticosterone level less than the normal blood amount of an adrenocortical steroid that induces glycogen deposition and regulates sodium conservation and potassium secretion http://purl.obolibrary.org/obo/MP_0002666 increased circulating aldosterone level http://purl.obolibrary.org/obo/MP_0005346 abnormal circulating aldosterone level increased in the blood concentration of the hormone that is secreted by the adrenal cortex and regulates sodium conservation and potassium secretion in the distal renal tubule http://purl.obolibrary.org/obo/MP_0002667 decreased circulating aldosterone level http://purl.obolibrary.org/obo/MP_0005346 abnormal circulating aldosterone level decreased in the blood concentration of the hormone that is secreted by the adrenal cortex and regulates sodium conservation and potassium secretion in the distal renal tubule http://purl.obolibrary.org/obo/MP_0002668 abnormal circulating potassium level http://purl.obolibrary.org/obo/MP_0011978 abnormal potassium ion homeostasis anomalous concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle http://purl.obolibrary.org/obo/MP_0002669 abnormal scrotum morphology http://purl.obolibrary.org/obo/MP_0009199 abnormal external male genitalia morphology any structural anomaly of the external sac of skin that encloses the testes http://purl.obolibrary.org/obo/MP_0002670 absent scrotum http://purl.obolibrary.org/obo/MP_0002669 abnormal scrotum morphology missing the external sac of skin that encloses the testes http://purl.obolibrary.org/obo/MP_0002671 belted http://purl.obolibrary.org/obo/MP_0002075 abnormal coat/hair pigmentation the appearance of a stripe of white fur around the circumference of the abdomen http://purl.obolibrary.org/obo/MP_0002672 abnormal pharyngeal arch artery morphology http://purl.obolibrary.org/obo/MP_0003410 abnormal artery development any structural anomaly of the vessels formed within the six (five in mammals) pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels http://purl.obolibrary.org/obo/MP_0002673 abnormal sperm number http://purl.obolibrary.org/obo/MP_0001929 abnormal gametogenesis increased or decreased numbers of spermatozoa http://purl.obolibrary.org/obo/MP_0002674 abnormal sperm motility http://purl.obolibrary.org/obo/MP_0004543 abnormal sperm physiology anomalies in the mobility of the spermatozoa http://purl.obolibrary.org/obo/MP_0002675 asthenozoospermia http://purl.obolibrary.org/obo/MP_0002674 abnormal sperm motility loss or reduction of the mobility of the spermatozoa, frequently associated with infertility http://purl.obolibrary.org/obo/MP_0002676 uterus hyperplasia http://purl.obolibrary.org/obo/MP_0004906 enlarged uterus overdevelopment or increased size, usually due an increased number of cells in the uterus http://purl.obolibrary.org/obo/MP_0002678 increased follicle recruitment http://purl.obolibrary.org/obo/MP_0001130 abnormal ovarian folliculogenesis greater frequency of the entry of arrested primordial follicles into the pool of growing follicles http://purl.obolibrary.org/obo/MP_0002679 abnormal corpus luteum morphology http://purl.obolibrary.org/obo/MP_0001126 abnormal ovary morphology any structural anomaly of the yellow endocrine body formed in the ovary after follicle rupture http://purl.obolibrary.org/obo/MP_0002680 decreased corpora lutea number http://purl.obolibrary.org/obo/MP_0002679 abnormal corpus luteum morphology fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrous cycle http://purl.obolibrary.org/obo/MP_0002681 increased corpora lutea number http://purl.obolibrary.org/obo/MP_0002679 abnormal corpus luteum morphology greater than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrous cycle http://purl.obolibrary.org/obo/MP_0002682 decreased mature ovarian follicle number http://purl.obolibrary.org/obo/MP_0009364 abnormal mature ovarian follicle morphology fewer than normal numbers of ovarian follicles that are ready for ovulation and present a blanched spot (the follicular stigma) where the graafian follicle is about to rupture on the surface of the ovary; a first maturation (meiotic) division of the primary oocyte usually occurs just prior to rupture of the follicle http://purl.obolibrary.org/obo/MP_0002683 delayed fertility http://purl.obolibrary.org/obo/MP_0002161 abnormal fertility/fecundity ability to produce live offspring occurring at a later than expected age http://purl.obolibrary.org/obo/MP_0002685 abnormal spermatogonia proliferation http://purl.obolibrary.org/obo/MP_0001156 abnormal spermatogenesis anomaly in the proliferation of the spermatogonial stem cells either due to abnormal mitosis or apoptosis http://purl.obolibrary.org/obo/MP_0002686 globozoospermia http://purl.obolibrary.org/obo/MP_0008898 abnormal acrosome morphology any structural anomaly of the acrosome resulting in a round sperm head http://purl.obolibrary.org/obo/MP_0002687 oligozoospermia http://purl.obolibrary.org/obo/MP_0004901 decreased male germ cell number reduced concentration of spermatozoa in the seminal fluid http://purl.obolibrary.org/obo/MP_0002689 abnormal molar morphology http://purl.obolibrary.org/obo/MP_0002100 abnormal tooth morphology any structural anomaly of the most posterior teeth located on either side of the jaw, characterized by a large crown and broad chewing surface http://purl.obolibrary.org/obo/MP_0002690 akinesia http://purl.obolibrary.org/obo/MP_0003313 abnormal locomotor activation acquired absence of voluntary movement or loss of the ability to move such as temporary or prolonged paralysis or freezing in place http://purl.obolibrary.org/obo/MP_0002691 small stomach http://purl.obolibrary.org/obo/MP_0000470 abnormal stomach morphology reduced size of the stomach http://purl.obolibrary.org/obo/MP_0002693 abnormal pancreas physiology http://purl.obolibrary.org/obo/MP_0002164 abnormal gland physiology any functional anomaly of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream http://purl.obolibrary.org/obo/MP_0002694 abnormal pancreas secretion http://purl.obolibrary.org/obo/MP_0002693 abnormal pancreas physiology anomaly in the production and/or release of biologically active substances from pancreatic tissue http://purl.obolibrary.org/obo/MP_0002695 abnormal circulating glucagon level http://purl.obolibrary.org/obo/MP_0005418 abnormal circulating hormone level anomaly in the blood concentration of the peptide hormone secreted by the alpha cells of the pancreas that normally plays an important role in regulation of blood glucose concentration, ketone metabolism, and several other biochemical and physiological processes http://purl.obolibrary.org/obo/MP_0002696 decreased circulating glucagon level http://purl.obolibrary.org/obo/MP_0002695 abnormal circulating glucagon level reduction in the blood concentration of the peptide hormone secreted by the alpha cells of the pancreas that normally plays an important role in regulation of blood glucose concentration, ketone metabolism, and several other biochemical and physiological processes http://purl.obolibrary.org/obo/MP_0002697 abnormal eye size http://purl.obolibrary.org/obo/MP_0002092 abnormal eye morphology deviation from the average range of eye size for a given organism http://purl.obolibrary.org/obo/MP_0002698 abnormal sclera morphology http://purl.obolibrary.org/obo/MP_0002092 abnormal eye morphology any structural anomaly of the fibrous, outer envelope of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea http://purl.obolibrary.org/obo/MP_0002699 abnormal vitreous body morphology http://purl.obolibrary.org/obo/MP_0005195 abnormal posterior eye segment morphology any structural anomaly of the transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina http://purl.obolibrary.org/obo/MP_0002700 opacity of vitreous body http://purl.obolibrary.org/obo/MP_0002699 abnormal vitreous body morphology the transparent gel filling the inner portion of the eyeball between the lens and retina becomes cloudy and impervious to light http://purl.obolibrary.org/obo/MP_0002702 decreased circulating free fatty acid level http://purl.obolibrary.org/obo/MP_0005282 decreased fatty acid level lower than normal levels of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacylglycerols are taken into tissues http://purl.obolibrary.org/obo/MP_0002703 abnormal renal tubule morphology http://purl.obolibrary.org/obo/MP_0003881 abnormal nephron morphology any structural anomaly of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule http://purl.obolibrary.org/obo/MP_0002704 tubular nephritis http://purl.obolibrary.org/obo/MP_0002703 abnormal renal tubule morphology inflammation of the renal tubules http://purl.obolibrary.org/obo/MP_0002705 dilated renal tubules http://purl.obolibrary.org/obo/MP_0002703 abnormal renal tubule morphology stretched or widened aperture of the luminal space of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule http://purl.obolibrary.org/obo/MP_0002706 abnormal kidney size http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology anomalous physical bulk one or both of the organs responsible for urine secretion http://purl.obolibrary.org/obo/MP_0002707 abnormal kidney weight http://purl.obolibrary.org/obo/MP_0002706 abnormal kidney size anomaly in the average weight of the organs responsible for urine secretion http://purl.obolibrary.org/obo/MP_0002708 nephrolithiasis http://purl.obolibrary.org/obo/MP_0005360 urolithiasis calculi occurring in the kidney http://purl.obolibrary.org/obo/MP_0002710 increased glucagon secretion http://purl.obolibrary.org/obo/MP_0003565 abnormal glucagon secretion greater than normal production or release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes http://purl.obolibrary.org/obo/MP_0002711 decreased glucagon secretion http://purl.obolibrary.org/obo/MP_0003565 abnormal glucagon secretion reduction in the production or release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes http://purl.obolibrary.org/obo/MP_0002712 increased circulating glucagon level http://purl.obolibrary.org/obo/MP_0002695 abnormal circulating glucagon level increase in the blood concentration of the peptide hormone secreted by the alpha cells of the pancreas that normally plays an important role in regulation of blood glucose concentration, ketone metabolism, and several other biochemical and physiological processes http://purl.obolibrary.org/obo/MP_0002713 abnormal glycogen catabolism http://purl.obolibrary.org/obo/MP_0005438 abnormal glycogen homeostasis inability to breakdown glycogen; or reduced or increased rate of glycogen breakdown http://purl.obolibrary.org/obo/MP_0002714 increased glycogen catabolism rate http://purl.obolibrary.org/obo/MP_0002713 abnormal glycogen catabolism increased breakdown of this highly branched polysaccharide composed of glucose subunits; glycogen is the major carbohydrate storage form in the body http://purl.obolibrary.org/obo/MP_0002715 decreased glycogen catabolism rate http://purl.obolibrary.org/obo/MP_0002713 abnormal glycogen catabolism decreased breakdown of this highly branched polysaccharide composed of glucose subunits; glycogen is the major carbohydrate storage form in the body http://purl.obolibrary.org/obo/MP_0002716 small male preputial glands http://purl.obolibrary.org/obo/MP_0002717 abnormal male preputial gland morphology reduced size of the sebaceous glands of the corona and neck of the glans penis http://purl.obolibrary.org/obo/MP_0002717 abnormal male preputial gland morphology http://purl.obolibrary.org/obo/MP_0013329 abnormal preputial gland morphology any structural anomaly of the paired, lobulated, modified sebaceous glands of the corona, the neck of the glans penis, and the inner surface of the prepuce with pheromonal functions in male rodents; male preputial secretions strongly attract females, may accelerate estrus, and have been implicated in intermale aggression; homologous to the clitoral glands (aka female preputial glands) in female rodents; there is no true anatomical equivalent in humans http://purl.obolibrary.org/obo/MP_0002718 abnormal inner cell mass morphology http://purl.obolibrary.org/obo/MP_0004957 abnormal blastocyst morphology any structural anomaly of the cells of the blastocyst that develop into the body of the embryo and some extraembryonic tissues http://purl.obolibrary.org/obo/MP_0002722 abnormal immune system organ morphology http://purl.obolibrary.org/obo/MP_0000685 abnormal immune system morphology any structural anomaly of lymphoid organs http://purl.obolibrary.org/obo/MP_0002723 abnormal immune serum protein physiology http://purl.obolibrary.org/obo/MP_0001790 abnormal immune system physiology abnormal concentration or function of circulating immune proteins http://purl.obolibrary.org/obo/MP_0002724 enhanced wound healing http://purl.obolibrary.org/obo/MP_0005023 abnormal wound healing increased ability to self-repair and close wounds http://purl.obolibrary.org/obo/MP_0002725 abnormal vein morphology http://purl.obolibrary.org/obo/MP_0001614 abnormal blood vessel morphology any structural anomaly of the blood vessels that carry blood towards the heart http://purl.obolibrary.org/obo/MP_0002726 abnormal pulmonary vein morphology http://purl.obolibrary.org/obo/MP_0002725 abnormal vein morphology any structural anomaly of the veins that return oxygenated blood from the lungs to the left atrium of the heart http://purl.obolibrary.org/obo/MP_0002727 decreased circulating insulin level http://purl.obolibrary.org/obo/MP_0001560 abnormal circulating insulin level less than normal levels of insulin in the blood http://purl.obolibrary.org/obo/MP_0002728 absent tibia http://purl.obolibrary.org/obo/MP_0000558 abnormal tibia morphology missing the medial and larger of the two bones of the lower leg http://purl.obolibrary.org/obo/MP_0002729 abnormal inner ear canal morphology http://purl.obolibrary.org/obo/MP_0000026 abnormal inner ear morphology any structural anomaly of the tubular ducts of the inner ear http://purl.obolibrary.org/obo/MP_0002730 head shaking http://purl.obolibrary.org/obo/MP_0001408 stereotypic behavior repetitive movement of the head in the horizontal plane http://purl.obolibrary.org/obo/MP_0002731 megacolon http://purl.obolibrary.org/obo/MP_0000495 abnormal colon morphology extreme dilation of the colon http://purl.obolibrary.org/obo/MP_0002732 increased trichoepithelioma incidence http://purl.obolibrary.org/obo/MP_0010300 increased skin tumor incidence greater than the expected number of benign hair follicle tumors that lack mature hair follicles, derived from basal cells of the hair follicles enclosing small keratin cysts, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0002733 abnormal thermal nociception http://purl.obolibrary.org/obo/MP_0001968 abnormal touch/ nociception abnormal capability to sense pain elicited by thermal stimulation http://purl.obolibrary.org/obo/MP_0002734 abnormal mechanical nociception http://purl.obolibrary.org/obo/MP_0001968 abnormal touch/ nociception abnormal capability to sense pain elicited by mechanical stimulation http://purl.obolibrary.org/obo/MP_0002735 abnormal chemical nociception http://purl.obolibrary.org/obo/MP_0001968 abnormal touch/ nociception abnormal capability to sense pain elicited by chemical stimulation http://purl.obolibrary.org/obo/MP_0002736 abnormal nociception after inflammation http://purl.obolibrary.org/obo/MP_0001968 abnormal touch/ nociception changes in pain thresholds after inflammation http://purl.obolibrary.org/obo/MP_0002738 hyperresponsive to tactile stimuli http://purl.obolibrary.org/obo/MP_0005407 hyperalgesia exaggerated reflex action normally induced by touch or pain http://purl.obolibrary.org/obo/MP_0002739 abnormal olfactory bulb development http://purl.obolibrary.org/obo/MP_0000913 abnormal brain development abnormality in the progression of the formation of the olfactory bulb http://purl.obolibrary.org/obo/MP_0002740 heart hypoplasia http://purl.obolibrary.org/obo/MP_0002188 small heart underdevelopment or reduced size of the heart, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0002741 small olfactory bulb http://purl.obolibrary.org/obo/MP_0000819 abnormal olfactory bulb morphology reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex http://purl.obolibrary.org/obo/MP_0002742 enlarged submandibular lymph nodes http://purl.obolibrary.org/obo/MP_0009627 abnormal submandibular lymph node morphology increased size of the submandibular lymph nodes http://purl.obolibrary.org/obo/MP_0002743 glomerulonephritis http://purl.obolibrary.org/obo/MP_0001859 kidney inflammation inflammation and scarring damage to the glomerulus usually resulting from an autoimmune response; often characterized by decreased production of urine, the presence of blood and protein in the urine, and/or by edema; often leads to kidney failure http://purl.obolibrary.org/obo/MP_0002745 abnormal atrioventricular valve morphology http://purl.obolibrary.org/obo/MP_0010435 abnormal heart atrium and ventricle connection any structural anomaly of the valves that gate the flow of blood from the atria into the ventricles http://purl.obolibrary.org/obo/MP_0002746 abnormal semilunar valve morphology http://purl.obolibrary.org/obo/MP_0000285 abnormal heart valve morphology any structural anomaly of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk http://purl.obolibrary.org/obo/MP_0002747 abnormal aortic valve morphology http://purl.obolibrary.org/obo/MP_0010429 abnormal heart left ventricle outflow tract morphology any structural anomaly of the valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle, and contains three cusps, the posterior (non-coronary), right anterior and left anterior cusps, attached to an outer fibrous ring (annulus) http://purl.obolibrary.org/obo/MP_0002748 abnormal pulmonary valve morphology http://purl.obolibrary.org/obo/MP_0010428 abnormal heart right ventricle outflow tract morphology any structural anomaly of the valve between the right ventricle and the pulmonary trunk, and contains three cusps, the anterior, right posterior and left posterior cusps, attached to an outer fibrous ring (annulus) http://purl.obolibrary.org/obo/MP_0002750 exophthalmos http://purl.obolibrary.org/obo/MP_0001299 abnormal eye distance/ position forward displacement, bulging, or protrusion of one or both eyeballs http://purl.obolibrary.org/obo/MP_0002751 abnormal autonomic nervous system morphology http://purl.obolibrary.org/obo/MP_0003632 abnormal nervous system morphology any structural anomaly of the function of the sensory and motor neurons that run between the central nervous system (especially the hypothalamus and medulla oblongata) and various internal organs (heart, lungs, endocrine and exocrine glands), responsible for controlling involuntary bodily functions http://purl.obolibrary.org/obo/MP_0002752 abnormal somatic nervous system morphology http://purl.obolibrary.org/obo/MP_0003632 abnormal nervous system morphology any structural anomaly of the part of the peripheral nervous system that is responsible for conveying voluntary motor and external sensory information, including all nerves controlling the skeletal muscular system and external sensory receptors (including balance, smell, sight, taste, touch and hearing sensory inputs) http://purl.obolibrary.org/obo/MP_0002753 dilated heart left ventricle http://purl.obolibrary.org/obo/MP_0008022 dilated heart ventricle the luminal space of the lower left chamber of the heart is increased in volume or area, usually with an increase in contained fluid http://purl.obolibrary.org/obo/MP_0002754 dilated heart right ventricle http://purl.obolibrary.org/obo/MP_0010563 increased heart right ventricle size the luminal space of the lower right chamber of the heart is increased in volume or area, usually with an increase in contained fluid http://purl.obolibrary.org/obo/MP_0002757 decreased vertical activity http://purl.obolibrary.org/obo/MP_0020167 abnormal vertical activity lesser than average time spent jumping or rearing http://purl.obolibrary.org/obo/MP_0002758 long tail http://purl.obolibrary.org/obo/MP_0011999 abnormal tail length increased length of tail relative to average of a given reference population http://purl.obolibrary.org/obo/MP_0002759 abnormal caudal vertebrae morphology http://purl.obolibrary.org/obo/MP_0002111 abnormal tail morphology any structural anomaly of the bony segments of the coccyx or tail http://purl.obolibrary.org/obo/MP_0002761 abnormal hippocampal mossy fiber morphology http://purl.obolibrary.org/obo/MP_0000807 abnormal hippocampus morphology absence or misprojection of axons of neuronal cells in the dentate gyrus http://purl.obolibrary.org/obo/MP_0002762 ectopic cerebellar granule cells http://purl.obolibrary.org/obo/MP_0011723 ectopic neuron granule cell body resides in a place other than the external or internal granule layer of the cerebellum http://purl.obolibrary.org/obo/MP_0002763 ectopic Bergmann glia cells http://purl.obolibrary.org/obo/MP_0010387 abnormal Bergmann glial cell morphology abnormal position of one or more astrocyte-type glia cells associated with Purkinje cells in the cerebellum http://purl.obolibrary.org/obo/MP_0002764 short tibia http://purl.obolibrary.org/obo/MP_0004686 decreased length of long bones reduced length of the medial and larger bone of the lower leg http://purl.obolibrary.org/obo/MP_0002765 short fibula http://purl.obolibrary.org/obo/MP_0004686 decreased length of long bones reduced length of the lateral and smaller of bone of the lower leg http://purl.obolibrary.org/obo/MP_0002766 situs inversus http://purl.obolibrary.org/obo/MP_0004133 heterotaxia lateral transposition or mirroring of the viscera of the thorax and abdomen, sometimes incomplete, with all organs maintaining the normal relative position with respect to each other http://purl.obolibrary.org/obo/MP_0002767 situs ambiguus http://purl.obolibrary.org/obo/MP_0004133 heterotaxia an abnormality in which the thoracic and abdominal organs are positioned in such a way with respect to each other and the left-right axis as to be not clearly lateralised and thus have neither the usual, or normal (situs solitus), nor the mirror-imaged (situs inversus) arrangements http://purl.obolibrary.org/obo/MP_0002768 small adrenal glands http://purl.obolibrary.org/obo/MP_0000639 abnormal adrenal gland morphology reduced size of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla http://purl.obolibrary.org/obo/MP_0002769 abnormal vas deferens morphology http://purl.obolibrary.org/obo/MP_0009205 abnormal internal male genitalia morphology any structural anomaly of the secretory duct of the testicle that carries spermatozoa, running from the epididymis, of which it is the continuation, to the prostatic urethra where it terminates to form ejaculatory duct http://purl.obolibrary.org/obo/MP_0002770 absent bulbourethral gland http://purl.obolibrary.org/obo/MP_0001169 abnormal bulbourethral gland morphology absence of any of the small paired racemose (compound tubulo-alveolar) glands below the apex of the prostate in males, located posterolateral to the membranous portion of the urethra at the base of the penis, between the two layers of the fascia of the urogenital diaphragm, in the deep perineal pouch, and enclosed by transverse fibers of the sphincter urethrae membranaceae muscle; they secrete a clear fluid known as pre-ejaculate (Cowper's fluid), and are homologous to the greater vestibular (Bartholin's) glands in the female http://purl.obolibrary.org/obo/MP_0002771 absent prostate gland anterior lobe http://purl.obolibrary.org/obo/MP_0001163 abnormal prostate gland anterior lobe morphology absence of the rodent prostate lobe that appears as a thin tubular structure, attached to the lesser curvature of the paired seminal vesicles http://purl.obolibrary.org/obo/MP_0002772 brachypodia http://purl.obolibrary.org/obo/MP_0000572 abnormal autopod morphology abnormally short feet http://purl.obolibrary.org/obo/MP_0002773 decreased circulating luteinizing hormone level http://purl.obolibrary.org/obo/MP_0005132 decreased luteinizing hormone level lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary http://purl.obolibrary.org/obo/MP_0002774 small prostate gland http://purl.obolibrary.org/obo/MP_0004959 abnormal prostate gland size reduced size of the gland in males that secretes part of the seminiferous fluid http://purl.obolibrary.org/obo/MP_0002776 Sertoli cell hyperplasia http://purl.obolibrary.org/obo/MP_0002784 abnormal Sertoli cell morphology overdevelopment or increased size, usually due an increased number of cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis http://purl.obolibrary.org/obo/MP_0002777 absent ovarian follicles http://purl.obolibrary.org/obo/MP_0008871 abnormal ovarian follicle number absence of the sac-like structure in the ovary which surrounds an ovum http://purl.obolibrary.org/obo/MP_0002778 meroanencephaly http://purl.obolibrary.org/obo/MP_0001890 anencephaly type of anencephaly in which the brain and cranium are present in rudimentary form http://purl.obolibrary.org/obo/MP_0002779 abnormal sex gland secretion http://purl.obolibrary.org/obo/MP_0005647 abnormal sex gland physiology anomaly in the production and/or release of hormones from a cell or a gland of the reproductive system http://purl.obolibrary.org/obo/MP_0002780 decreased circulating testosterone level http://purl.obolibrary.org/obo/MP_0005180 abnormal circulating testosterone level reduction in the blood concentration of a potent androgen that promotes development of male secondary sex characteristics and the development of spermatozoa and may regulate sexual desire and help maintain bone and muscle health in both males and females http://purl.obolibrary.org/obo/MP_0002781 increased circulating testosterone level http://purl.obolibrary.org/obo/MP_0005180 abnormal circulating testosterone level greater than the normal blood concentration of a potent androgen that promotes development of male secondary sex characteristics and the development of spermatozoa and may regulate sexual desire and help maintain bone and muscle health in both males and females http://purl.obolibrary.org/obo/MP_0002782 abnormal testes secretion http://purl.obolibrary.org/obo/MP_0004884 abnormal testis physiology anomaly in the production and/or release of hormones from testicular tissue http://purl.obolibrary.org/obo/MP_0002783 abnormal ovarian secretion http://purl.obolibrary.org/obo/MP_0003507 abnormal ovary physiology anomaly in the production and/or release of hormones from ovarian tissue http://purl.obolibrary.org/obo/MP_0002784 abnormal Sertoli cell morphology http://purl.obolibrary.org/obo/MP_0011750 abnormal seminiferous tubule epithelium morphology any structural anomaly of the supporting cells of the seminiferous tubule epithelium that create the blood-testes barrier and enable spermatogenesis http://purl.obolibrary.org/obo/MP_0002785 absent Leydig cells http://purl.obolibrary.org/obo/MP_0002786 abnormal Leydig cell morphology lack of the interstitial cells of the seminiferous tubules that secrete testosterone http://purl.obolibrary.org/obo/MP_0002786 abnormal Leydig cell morphology http://purl.obolibrary.org/obo/MP_0002216 abnormal seminiferous tubule morphology any structural anomaly of the interstitial cells near the seminiferous tubules that secrete testosterone http://purl.obolibrary.org/obo/MP_0002787 pseudohermaphroditism http://purl.obolibrary.org/obo/MP_0002212 abnormal secondary sex determination unambiguous gonadal sex (i.e. possesses either testes or ovaries, consistent with chromosomal sex) but has ambiguous secondary sexual characteristics http://purl.obolibrary.org/obo/MP_0002788 female pseudohermaphroditism http://purl.obolibrary.org/obo/MP_0002787 pseudohermaphroditism pseudohermaphroditism in which the gonads are female (ovaries) and the karyotype is XX but the secondary sex characteristics are male-like or ambiguous http://purl.obolibrary.org/obo/MP_0002789 male pseudohermaphroditism http://purl.obolibrary.org/obo/MP_0002787 pseudohermaphroditism pseudohermaphroditism in which the gonads are male (testes) and the karyotype is XY but the secondary sex characteristics are female-like or ambiguous http://purl.obolibrary.org/obo/MP_0002790 decreased circulating follicle stimulating hormone level http://purl.obolibrary.org/obo/MP_0005130 decreased follicle stimulating hormone level less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis http://purl.obolibrary.org/obo/MP_0002791 steatorrhea http://purl.obolibrary.org/obo/MP_0003868 abnormal feces composition passage of large amounts of fat in the feces due to the inability to digest and absorb it http://purl.obolibrary.org/obo/MP_0002792 abnormal retinal vasculature morphology http://purl.obolibrary.org/obo/MP_0001614 abnormal blood vessel morphology any anomaly of the structure or arrangement of blood vessels supplying the retina http://purl.obolibrary.org/obo/MP_0002794 lenticonus http://purl.obolibrary.org/obo/MP_0001303 abnormal lens morphology a conical bulging of the lens capsule and the underlying cortex of the eye http://purl.obolibrary.org/obo/MP_0002795 dilated cardiomyopathy http://purl.obolibrary.org/obo/MP_0005330 cardiomyopathy decreased function of the heart associated with cardiac enlargement and congestive heart failure http://purl.obolibrary.org/obo/MP_0002796 impaired skin barrier function http://purl.obolibrary.org/obo/MP_0005501 abnormal skin physiology impaired ability of the skin to regulate water loss; frequently leads to dehydration http://purl.obolibrary.org/obo/MP_0002797 increased thigmotaxis http://purl.obolibrary.org/obo/MP_0001363 increased anxiety-related response greater than average preference for staying at the perimeter walls of an open area or in an enclosed versus exposed area; may be used as an indicator of increased anxiety response http://purl.obolibrary.org/obo/MP_0002798 abnormal active avoidance behavior http://purl.obolibrary.org/obo/MP_0001462 abnormal avoidance learning behavior anomaly in the ability to escape a hostile environment to actively avoid the unpleasant or punishing stimuli ( e.g. shock) previously encountered in this environment http://purl.obolibrary.org/obo/MP_0002799 abnormal passive avoidance behavior http://purl.obolibrary.org/obo/MP_0001462 abnormal avoidance learning behavior anomaly in the ability of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously with prolonged latency http://purl.obolibrary.org/obo/MP_0002800 abnormal short term object recognition memory http://purl.obolibrary.org/obo/MP_0001468 abnormal temporal memory anomaly in the short-term memory for objects is established during the first few minutes after training http://purl.obolibrary.org/obo/MP_0002801 abnormal long term object recognition memory http://purl.obolibrary.org/obo/MP_0001468 abnormal temporal memory anomaly in long-term memory for objects that is consolidated over hours and days after training http://purl.obolibrary.org/obo/MP_0002802 abnormal discrimination learning http://purl.obolibrary.org/obo/MP_0002063 abnormal learning/memory/conditioning anomaly in the ability to exhibit a differential response to different stimuli that is achieved by the reinforcement of the desired response for each particular stimulus http://purl.obolibrary.org/obo/MP_0002803 abnormal operant conditioning behavior http://purl.obolibrary.org/obo/MP_0002062 abnormal associative learning anomaly in the operant conditioning system refers to abnormalities in scheduled controlled behavior; behavioral assessment occurs in an automated chamber where responses are reinforced with food http://purl.obolibrary.org/obo/MP_0002804 abnormal motor learning http://purl.obolibrary.org/obo/MP_0002063 abnormal learning/memory/conditioning anomaly in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning http://purl.obolibrary.org/obo/MP_0002805 abnormal conditioned taste aversion behavior http://purl.obolibrary.org/obo/MP_0001462 abnormal avoidance learning behavior anomaly in the ability of an animal to learn to avoid food sources that were previously associated with aversive internal stimuli or sickness such as a drug that induces sickness http://purl.obolibrary.org/obo/MP_0002806 abnormal conditioned emotional response http://purl.obolibrary.org/obo/MP_0002062 abnormal associative learning anomaly in an emotional response that has been acquired by conditioning http://purl.obolibrary.org/obo/MP_0002807 abnormal eye blink conditioning behavior http://purl.obolibrary.org/obo/MP_0002062 abnormal associative learning anomaly in the ability of an animal to learn to blink in anticipation of an aversive stimulus (e.g., an air puff to the eyelid) following repeated pairings with a neutral stimulus (e.g., a tone); such learning is only adaptive if the animal is able to learn the precise timing between the conditioned and unconditioned stimuli http://purl.obolibrary.org/obo/MP_0002808 abnormal barbering behavior http://purl.obolibrary.org/obo/MP_0001440 abnormal grooming behavior anomaly in the behavior of plucking of fur/hair or whiskers/vibrissae from other individuals of a cohort (hetero-barbering) or oneself (self-barbering); it is recognized as patches of unevenly chopped hair and the underlying skin is seldom inflamed http://purl.obolibrary.org/obo/MP_0002809 increased spinal cord size http://purl.obolibrary.org/obo/MP_0000955 abnormal spinal cord morphology larger appearance of the spinal cord http://purl.obolibrary.org/obo/MP_0002810 microcytic anemia http://purl.obolibrary.org/obo/MP_0001577 anemia a reduction in the mean total mass of erythrocytes in which the remaining circulating erythrocyte corpuscular volume is smaller than normal; most commonly due to iron deficiency but also sickle cell disease and other conditions that result in hemoglobin synthesis failure or insufficiency http://purl.obolibrary.org/obo/MP_0002811 macrocytic anemia http://purl.obolibrary.org/obo/MP_0001577 anemia deficiency of red blood cells in which the remaining circulating erythrocyte corpuscular volume is larger than normal; most commonly due to megaloblastic anemia, or a deficiency of either vitamin B12 or folic acid http://purl.obolibrary.org/obo/MP_0002812 spherocytosis http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology the presence of sphere-shaped erythrocytes in the circulating blood http://purl.obolibrary.org/obo/MP_0002813 microcytosis http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology the presence of unusually small erythrocytes in the circulating blood http://purl.obolibrary.org/obo/MP_0002814 hyperchromasia http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology increased capacity of a cell to stain with dye; usually refers to staining of cell nuclei with hematoxylin http://purl.obolibrary.org/obo/MP_0002816 colitis http://purl.obolibrary.org/obo/MP_0003304 large intestinal inflammation local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine http://purl.obolibrary.org/obo/MP_0002817 abnormal tooth mineralization http://purl.obolibrary.org/obo/MP_0003930 abnormal tooth hard tissue morphology abnormalities in the process by which calcium salts are deposited into the dental enamel, dentin and cementum http://purl.obolibrary.org/obo/MP_0002818 abnormal dentin morphology http://purl.obolibrary.org/obo/MP_0003930 abnormal tooth hard tissue morphology any structural anomaly in the hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root http://purl.obolibrary.org/obo/MP_0002819 abnormal pulp cavity morphology http://purl.obolibrary.org/obo/MP_0002100 abnormal tooth morphology any structural anomaly of the central hollow space of a tooth http://purl.obolibrary.org/obo/MP_0002820 abnormal premaxilla morphology http://purl.obolibrary.org/obo/MP_0000455 abnormal maxilla morphology any structural anomaly of the anterior and inner portion of the maxilla http://purl.obolibrary.org/obo/MP_0002822 catalepsy http://purl.obolibrary.org/obo/MP_0004924 abnormal behavior a condition characterized by inactivity, lack of response to stimuli, and a tendency to maintain an immobile posture; the limbs tend to remain in whatever position they are placed (waxy rigidity); occurs with some psychoses, nervous system drug toxicity, and other conditions http://purl.obolibrary.org/obo/MP_0002823 abnormal rib development http://purl.obolibrary.org/obo/MP_0002113 abnormal skeleton development anomalous formation of the bones forming the bony wall of the chest http://purl.obolibrary.org/obo/MP_0002824 abnormal chorioallantoic fusion http://purl.obolibrary.org/obo/MP_0001712 abnormal placenta development anomaly in the process by which a highly vascularized extra-embryonic fetal membrane is formed by fusion of the chorion and allantois; in most mammals, the chorioallantois constitutes the fetal portion of the placenta http://purl.obolibrary.org/obo/MP_0002825 abnormal notochord morphology http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology any structural anomaly of the axial fibrocellular cord in embryos around which develops the vertebral primordia http://purl.obolibrary.org/obo/MP_0002826 tonic seizures http://purl.obolibrary.org/obo/MP_0000947 convulsive seizures increased number or decreased threshold for the induction of a seizure characterized by muscle rigidity http://purl.obolibrary.org/obo/MP_0002827 abnormal renal corpuscle morphology http://purl.obolibrary.org/obo/MP_0003881 abnormal nephron morphology any structural anomaly of the structure containing the glomerular capsule and the glomerulus that serves as the initial blood-filtering component of a nephron http://purl.obolibrary.org/obo/MP_0002828 abnormal renal glomerular capsule morphology http://purl.obolibrary.org/obo/MP_0002827 abnormal renal corpuscle morphology any structural anomaly of the expanded beginning of a nephron that contains the glomerulus http://purl.obolibrary.org/obo/MP_0002829 abnormal juxtaglomerular apparatus morphology http://purl.obolibrary.org/obo/MP_0000521 abnormal kidney cortex morphology any structural anomaly of the complex of modified smooth muscle cells consisting of juxtaglomerular cells, extraglomerular mesangium lacis cells, the macula densa of the distal convoluted tubule, and granular epithelial peripolar cells; these cells are found in the walls of afferent and efferent glomerular arterioles http://purl.obolibrary.org/obo/MP_0002830 gallstones http://purl.obolibrary.org/obo/MP_0005083 abnormal biliary tract morphology caliculi in the gallbladder or a bile duct; chemical composition of cholesterol, calcium carbonate or calcium bilirubinate http://purl.obolibrary.org/obo/MP_0002831 absent Peyer's patches http://purl.obolibrary.org/obo/MP_0000696 abnormal Peyer's patch morphology lymphoid tissue missing from the mucosa of the small intestine http://purl.obolibrary.org/obo/MP_0002832 coarse hair http://purl.obolibrary.org/obo/MP_0002074 abnormal hair texture hair shafts that are twisted or coiled and are of uneven thickness produce an overall rugged or uneven appearance and roughness to the touch http://purl.obolibrary.org/obo/MP_0002833 increased heart weight http://purl.obolibrary.org/obo/MP_0004857 abnormal heart weight greater than average weight of the heart compared to controls http://purl.obolibrary.org/obo/MP_0002834 decreased heart weight http://purl.obolibrary.org/obo/MP_0004857 abnormal heart weight less than average weight of the heart compared to controls http://purl.obolibrary.org/obo/MP_0002835 abnormal cranial suture morphology http://purl.obolibrary.org/obo/MP_0002932 abnormal joint morphology any structural anomaly of the dense, fibrous connective tissue joint between the bones of the head http://purl.obolibrary.org/obo/MP_0002836 abnormal chorion morphology http://purl.obolibrary.org/obo/MP_0002086 abnormal extraembryonic tissue morphology any structural anomaly of the outermost extraembryonic membrane http://purl.obolibrary.org/obo/MP_0002837 dystrophic cardiac calcinosis http://purl.obolibrary.org/obo/MP_0000266 abnormal heart morphology a condition characterized by the localized deposition of calcium salts in the heart; often occurring in association with inflammation or atherosclerotic lesions and other pathological states http://purl.obolibrary.org/obo/MP_0002838 decreased susceptibility to dystrophic cardiac calcinosis http://purl.obolibrary.org/obo/MP_0002837 dystrophic cardiac calcinosis less likely to be stricken by dystrophic cardiac calcinosis http://purl.obolibrary.org/obo/MP_0002839 increased susceptibility to dystrophic cardiac calcinosis http://purl.obolibrary.org/obo/MP_0002837 dystrophic cardiac calcinosis more likely to be stricken by dystrophic cardiac calcinosis http://purl.obolibrary.org/obo/MP_0002840 abnormal lens fiber morphology http://purl.obolibrary.org/obo/MP_0001303 abnormal lens morphology any structural anomaly of the elongated cells of the crystalline lens of the eye http://purl.obolibrary.org/obo/MP_0002841 impaired skeletal muscle contractility http://purl.obolibrary.org/obo/MP_0000738 impaired muscle contractility inability or reduced ability of the skeletal muscle to shorten or to develop increased tension http://purl.obolibrary.org/obo/MP_0002842 increased systemic arterial blood pressure http://purl.obolibrary.org/obo/MP_0000230 abnormal systemic arterial blood pressure increased tension of the blood within the systemic arteries http://purl.obolibrary.org/obo/MP_0002843 decreased systemic arterial blood pressure http://purl.obolibrary.org/obo/MP_0000230 abnormal systemic arterial blood pressure decreased tension of the blood within the systemic arteries http://purl.obolibrary.org/obo/MP_0002844 aortic hypertrophy http://purl.obolibrary.org/obo/MP_0000272 abnormal aorta morphology increase in the bulk size of the aorta http://purl.obolibrary.org/obo/MP_0002845 abnormal aortic weight http://purl.obolibrary.org/obo/MP_0000272 abnormal aorta morphology anomaly in the average weight of the aorta http://purl.obolibrary.org/obo/MP_0002846 abnormal aortic mass http://purl.obolibrary.org/obo/MP_0000272 abnormal aorta morphology altered physical volume or bulk of the aorta http://purl.obolibrary.org/obo/MP_0002847 abnormal renal glomerular filtration rate http://purl.obolibrary.org/obo/MP_0013284 abnormal renal glomerular filtration anomaly in the rate of the process in which plasma is filtered through the glomerular membrane, which consists of capillary endothelial cells, the basement membrane, and epithelial cells; the glomerular filtrate is the same as plasma except it has no significant amount of protein http://purl.obolibrary.org/obo/MP_0002849 abnormal saccharin consumption http://purl.obolibrary.org/obo/MP_0005449 abnormal food intake subjects demonstrate interest in ingesting saccharine http://purl.obolibrary.org/obo/MP_0002850 saccharin preference http://purl.obolibrary.org/obo/MP_0011976 sweet preference subjects demonstrate predilection for saccharine over other offered substance http://purl.obolibrary.org/obo/MP_0002851 abnormal circulating sulfate level http://purl.obolibrary.org/obo/MP_0006357 abnormal circulating mineral level altered concentration of sulfate in the blood http://purl.obolibrary.org/obo/MP_0002852 hypersulfatemia http://purl.obolibrary.org/obo/MP_0002851 abnormal circulating sulfate level abnormally high concentration of sulfate in the circulating blood http://purl.obolibrary.org/obo/MP_0002853 hyposulfatemia http://purl.obolibrary.org/obo/MP_0002851 abnormal circulating sulfate level abnormally low concentration of sulfate in the circulating blood http://purl.obolibrary.org/obo/MP_0002855 abnormal cochlear ganglion morphology http://purl.obolibrary.org/obo/MP_0001081 abnormal cranial ganglia morphology any structural anomaly of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve) http://purl.obolibrary.org/obo/MP_0002856 abnormal vestibular ganglion morphology http://purl.obolibrary.org/obo/MP_0001081 abnormal cranial ganglia morphology any structural anomaly of the group of neurons associated with the vestibular part of the eighth cranial nerve that are involved in equilibration http://purl.obolibrary.org/obo/MP_0002857 cochlear ganglion degeneration http://purl.obolibrary.org/obo/MP_0002855 abnormal cochlear ganglion morphology loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain http://purl.obolibrary.org/obo/MP_0002858 abnormal posterior semicircular canal morphology http://purl.obolibrary.org/obo/MP_0002428 abnormal semicircular canal morphology any structural anomaly of the posterior segment of the long bony tube of the labyrinth that is involved in the sense of balance http://purl.obolibrary.org/obo/MP_0002859 abnormal inner ear canal fusion http://purl.obolibrary.org/obo/MP_0002729 abnormal inner ear canal morphology any structural anomaly or mistiming of the fusion of the canal primordia during development http://purl.obolibrary.org/obo/MP_0002861 abnormal tail bud morphology http://purl.obolibrary.org/obo/MP_0006281 abnormal tail development anomalous formation of the primordial region of the embryo that arises to form the tail of the adult; appears approximately ten days following conception as a short stump, and then initiates elongation and thinning in normal development http://purl.obolibrary.org/obo/MP_0002862 altered righting response http://purl.obolibrary.org/obo/MP_0002980 abnormal postural reflex altered ability or changed amount of time needed to recover from an unnatural position to a normal position and/or to resist any force acting to place an organism into a false position http://purl.obolibrary.org/obo/MP_0002863 improved righting response http://purl.obolibrary.org/obo/MP_0002862 altered righting response faster ability or less amount of time needed to recover from an unnatural position to a normal position and/or to resist any force acting to place an organism into a false position http://purl.obolibrary.org/obo/MP_0002864 abnormal ocular fundus morphology http://purl.obolibrary.org/obo/MP_0005195 abnormal posterior eye segment morphology any structural anomaly of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope http://purl.obolibrary.org/obo/MP_0002865 increased growth rate http://purl.obolibrary.org/obo/MP_0001731 abnormal postnatal growth reduced length of time to reach a developmental stage or stages http://purl.obolibrary.org/obo/MP_0002866 abnormal glutamic acid decarboxylase level http://purl.obolibrary.org/obo/MP_0005319 abnormal enzyme/ coenzyme level aberrant concentration of the enzyme that catalyzes the conversion of glutamate to gamma-aminobutyric acid (GABA) and carbon dioxide, and regulates GABA levels in nervous tissues http://purl.obolibrary.org/obo/MP_0002867 increased glutamic acid decarboxylase level http://purl.obolibrary.org/obo/MP_0002866 abnormal glutamic acid decarboxylase level greater than normal concentration of the enzyme that catalyzes the conversion of glutamate to gamma-aminobutyric acid (GABA) and carbon dioxide and regulates GABA levels in nervous tissues http://purl.obolibrary.org/obo/MP_0002868 decreased glutamic acid decarboxylase level http://purl.obolibrary.org/obo/MP_0002866 abnormal glutamic acid decarboxylase level less than normal concentration of the enzyme that catalyzes the conversion of glutamate to gamma-aminobutyric acid (GABA) and carbon dioxide, and regulates GABA levels in nervous tissues http://purl.obolibrary.org/obo/MP_0002869 increased anti-insulin autoantibody level http://purl.obolibrary.org/obo/MP_0003725 increased autoantibody level elevated level of antibodies to insulin present in the sera http://purl.obolibrary.org/obo/MP_0002870 decreased anti-insulin autoantibody level http://purl.obolibrary.org/obo/MP_0003726 decreased autoantibody level reduced level of antibodies to insulin present in the sera http://purl.obolibrary.org/obo/MP_0002871 albuminuria http://purl.obolibrary.org/obo/MP_0002962 increased urine protein level presence of excess albumin in the urine http://purl.obolibrary.org/obo/MP_0002872 polycythemia http://purl.obolibrary.org/obo/MP_0003131 increased erythrocyte cell number an excess of circulating red blood cells http://purl.obolibrary.org/obo/MP_0002874 decreased hemoglobin content http://purl.obolibrary.org/obo/MP_0005563 abnormal hemoglobin content decrease in the total hemoglobin content in the circulating blood http://purl.obolibrary.org/obo/MP_0002875 decreased erythrocyte cell number http://purl.obolibrary.org/obo/MP_0011182 decreased hematopoietic cell number reduced number of the cells that transport oxygen, red blood cells, per unit http://purl.obolibrary.org/obo/MP_0002876 abnormal thyroid physiology http://purl.obolibrary.org/obo/MP_0002164 abnormal gland physiology any functional anomaly of this endocrine gland that normally produces hormones that regulate the metabolic rate of the body http://purl.obolibrary.org/obo/MP_0002877 abnormal melanocyte morphology http://purl.obolibrary.org/obo/MP_0001186 pigmentation phenotype any structural anomaly of the cells that produce pigment http://purl.obolibrary.org/obo/MP_0002878 abnormal corticospinal tract morphology http://purl.obolibrary.org/obo/MP_0000778 abnormal nervous system tract morphology any structural anomaly of the corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract http://purl.obolibrary.org/obo/MP_0002879 increased cellular sensitivity to X-ray irradiation http://purl.obolibrary.org/obo/MP_0004227 increased cellular sensitivity to ionizing radiation increased incidence of cell death following exposure to X-ray irradiation http://purl.obolibrary.org/obo/MP_0002880 opisthotonus http://purl.obolibrary.org/obo/MP_0003492 abnormal involuntary movement a form of tetanic spasm in which the head, neck and spine are bent backward and the body is bowed forward http://purl.obolibrary.org/obo/MP_0002881 long hair http://purl.obolibrary.org/obo/MP_0002073 abnormal hair growth increased average length of the coat hairs http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology http://purl.obolibrary.org/obo/MP_0003632 abnormal nervous system morphology any structural anomaly of the cells of the nervous system that receive, conduct, and transmit impulses http://purl.obolibrary.org/obo/MP_0002883 chromatolysis http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology the dissolution of the granules of chromophil substance in a nerve cell body that may occur in injured cells or axons http://purl.obolibrary.org/obo/MP_0002884 abnormal pharyngeal arch morphology http://purl.obolibrary.org/obo/MP_0003935 abnormal craniofacial development any structural anomaly of the transient structures of the embryo that develop into regions of the head, neck and ears http://purl.obolibrary.org/obo/MP_0002885 abnormal AMPA-mediated synaptic currents http://purl.obolibrary.org/obo/MP_0002886 abnormal glutamate-mediated receptor currents change in the measured amplitude, current density or duration of response to stimulation of AMPA receptors http://purl.obolibrary.org/obo/MP_0002886 abnormal glutamate-mediated receptor currents http://purl.obolibrary.org/obo/MP_0002206 abnormal CNS synaptic transmission change in the measured amplitude, current density or duration of response to stimulation of glutamatergic receptors http://purl.obolibrary.org/obo/MP_0002887 decreased susceptibility to pharmacologically induced seizures http://purl.obolibrary.org/obo/MP_0012348 decreased susceptibility to induction of seizure by inducing agent ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals; exhibit a higher threshold to induce seizure activity http://purl.obolibrary.org/obo/MP_0002888 abnormal NMDA-mediated synaptic currents http://purl.obolibrary.org/obo/MP_0002886 abnormal glutamate-mediated receptor currents change in the measured amplitude, current density or duration of response to stimulation of NMDA receptors http://purl.obolibrary.org/obo/MP_0002891 increased insulin sensitivity http://purl.obolibrary.org/obo/MP_0002078 abnormal glucose homeostasis greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia http://purl.obolibrary.org/obo/MP_0002892 decreased superior colliculus size http://purl.obolibrary.org/obo/MP_0000904 abnormal superior colliculus morphology decreased size of the paired superior eminence of the mesencephalic tectum http://purl.obolibrary.org/obo/MP_0002893 ketoaciduria http://purl.obolibrary.org/obo/MP_0010028 aciduria elevated amount of acetoacetate, 3-hydroxybutyrate (beta-hydroxybutyrate) and/or acteone in the urine, which are produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus http://purl.obolibrary.org/obo/MP_0002894 abnormal otolith morphology http://purl.obolibrary.org/obo/MP_0002895 abnormal otolithic membrane morphology any structural anomaly of the crystalline particles composed of calcium carbonate and a protein which adhere to the gelatinous membrane of the maculae of the utricle and saccule (otolithic membrane) http://purl.obolibrary.org/obo/MP_0002895 abnormal otolithic membrane morphology http://purl.obolibrary.org/obo/MP_0004427 abnormal vestibular labyrinth morphology any structural anomaly of the gelatinous membrane which is supported by the stereocilia of the hair cells of the maculae of the saccule and utriculus of the inner ear; adhering to its surface are numerous calciferous crystalline particles called otoliths (statoconia) http://purl.obolibrary.org/obo/MP_0002896 abnormal bone mineralization http://purl.obolibrary.org/obo/MP_0008271 abnormal bone ossification defect in the process by which minerals are deposited into bone http://purl.obolibrary.org/obo/MP_0002897 blotchy skin http://purl.obolibrary.org/obo/MP_0009931 abnormal skin appearance regions of spotted discoloration appearing in the dermal tissue http://purl.obolibrary.org/obo/MP_0002898 absent cartilage http://purl.obolibrary.org/obo/MP_0000163 abnormal cartilage morphology absence of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the thorax, and tubular structures, but which also comprises most of the skeleton in early fetal life http://purl.obolibrary.org/obo/MP_0002899 fatigue http://purl.obolibrary.org/obo/MP_0004924 abnormal behavior easily exhausted due to mental or physical exertion http://purl.obolibrary.org/obo/MP_0002900 abnormal urine phosphate level http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis any change in the amount of phosphate in the urine http://purl.obolibrary.org/obo/MP_0002901 increased urine phosphate level http://purl.obolibrary.org/obo/MP_0002900 abnormal urine phosphate level an increase in phosphate amount in the urine http://purl.obolibrary.org/obo/MP_0002902 decreased urine phosphate level http://purl.obolibrary.org/obo/MP_0002900 abnormal urine phosphate level reduced phosphate amount in the urine http://purl.obolibrary.org/obo/MP_0002903 abnormal circulating parathyroid hormone level http://purl.obolibrary.org/obo/MP_0005418 abnormal circulating hormone level anomaly in the blood concentration of the hormone that regulates and maintains intracellular calcium levels in the body http://purl.obolibrary.org/obo/MP_0002904 increased circulating parathyroid hormone level http://purl.obolibrary.org/obo/MP_0002903 abnormal circulating parathyroid hormone level greater blood concentration of the hormone that regulates and maintains intracellular calcium levels in the body http://purl.obolibrary.org/obo/MP_0002905 decreased circulating parathyroid hormone level http://purl.obolibrary.org/obo/MP_0002903 abnormal circulating parathyroid hormone level reduction in the blood concentration of the hormone that regulates and maintains intracellular calcium levels in the body http://purl.obolibrary.org/obo/MP_0002906 increased susceptibility to pharmacologically induced seizures http://purl.obolibrary.org/obo/MP_0012349 increased susceptibility to induction of seizure by inducing agent inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals; exhibit a lower threshold to induce seizure activity http://purl.obolibrary.org/obo/MP_0002907 abnormal parturition http://purl.obolibrary.org/obo/MP_0009661 abnormal pregnancy defect in the process of labor and delivery in female animals http://purl.obolibrary.org/obo/MP_0002908 delayed wound healing http://purl.obolibrary.org/obo/MP_0005023 abnormal wound healing longer time requirement for the ability to self-repair and close wounds than normal http://purl.obolibrary.org/obo/MP_0002909 abnormal adrenal gland physiology http://purl.obolibrary.org/obo/MP_0002164 abnormal gland physiology any functional anomaly of the surparenal gland, including the ability to produce and secrete hormones http://purl.obolibrary.org/obo/MP_0002910 abnormal excitatory postsynaptic currents http://purl.obolibrary.org/obo/MP_0002206 abnormal CNS synaptic transmission defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization http://purl.obolibrary.org/obo/MP_0002911 abnormal inhibitory postsynaptic potential http://purl.obolibrary.org/obo/MP_0002206 abnormal CNS synaptic transmission defect in the membrane potential detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization http://purl.obolibrary.org/obo/MP_0002912 abnormal excitatory postsynaptic potential http://purl.obolibrary.org/obo/MP_0002206 abnormal CNS synaptic transmission defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization http://purl.obolibrary.org/obo/MP_0002913 abnormal PNS synaptic transmission http://purl.obolibrary.org/obo/MP_0003635 abnormal synaptic transmission defect in the communication from a neuron to a target across a synapse in the peripheral nervous system http://purl.obolibrary.org/obo/MP_0002914 abnormal endplate potential http://purl.obolibrary.org/obo/MP_0002913 abnormal PNS synaptic transmission defect in the excitatory response of peripheral synapses to stimulation; these amplitudes are larger than central synapse potentials http://purl.obolibrary.org/obo/MP_0002915 abnormal synaptic depression http://purl.obolibrary.org/obo/MP_0002206 abnormal CNS synaptic transmission changes in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation http://purl.obolibrary.org/obo/MP_0002916 increased synaptic depression http://purl.obolibrary.org/obo/MP_0002915 abnormal synaptic depression increase in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation http://purl.obolibrary.org/obo/MP_0002917 decreased synaptic depression http://purl.obolibrary.org/obo/MP_0002915 abnormal synaptic depression decrease in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation http://purl.obolibrary.org/obo/MP_0002918 abnormal paired-pulse facilitation http://purl.obolibrary.org/obo/MP_0003635 abnormal synaptic transmission defects in the enhanced response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus http://purl.obolibrary.org/obo/MP_0002919 enhanced paired-pulse facilitation http://purl.obolibrary.org/obo/MP_0002918 abnormal paired-pulse facilitation increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus http://purl.obolibrary.org/obo/MP_0002920 decreased paired-pulse facilitation http://purl.obolibrary.org/obo/MP_0002918 abnormal paired-pulse facilitation reduction in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus http://purl.obolibrary.org/obo/MP_0002921 abnormal post-tetanic potentiation http://purl.obolibrary.org/obo/MP_0002206 abnormal CNS synaptic transmission defects in the size or duration of potentials that persist after tetanic stimulation of central synapses http://purl.obolibrary.org/obo/MP_0002922 decreased post-tetanic potentiation http://purl.obolibrary.org/obo/MP_0002921 abnormal post-tetanic potentiation reduction in the size or duration of potentials that persist after tetanic stimulation of central synapses http://purl.obolibrary.org/obo/MP_0002923 increased post-tetanic potentiation http://purl.obolibrary.org/obo/MP_0002921 abnormal post-tetanic potentiation increase in the size or duration of potentials that persist after tetanic stimulation of central synapses http://purl.obolibrary.org/obo/MP_0002924 delayed CNS synapse formation http://purl.obolibrary.org/obo/MP_0004996 abnormal CNS synapse formation increase in time required to complete the process of generating connections between an axon and effector tissue or neuron http://purl.obolibrary.org/obo/MP_0002925 abnormal cardiovascular development http://purl.obolibrary.org/obo/MP_0002127 abnormal cardiovascular system morphology aberrant formation or incomplete differentiation of the cardiovascular system http://purl.obolibrary.org/obo/MP_0002926 aganglionic megacolon http://purl.obolibrary.org/obo/MP_0002731 megacolon extreme dilation of the colon due to defects in innervation from the ganglia, or absence of the ganglia of the myenteric plexus http://purl.obolibrary.org/obo/MP_0002927 toxic megacolon http://purl.obolibrary.org/obo/MP_0002731 megacolon severe non-obstructive dilation of the colon http://purl.obolibrary.org/obo/MP_0002928 abnormal bile duct morphology http://purl.obolibrary.org/obo/MP_0005083 abnormal biliary tract morphology any structural anomaly of the channels that secrete bile from the liver to the gall bladder and intestines http://purl.obolibrary.org/obo/MP_0002929 abnormal bile duct development http://purl.obolibrary.org/obo/MP_0003943 abnormal hepatobiliary system development incomplete or aberrant differentiation of the channels that secrete bile from the liver to the gall bladder and intestines http://purl.obolibrary.org/obo/MP_0002931 glutaricadicuria http://purl.obolibrary.org/obo/MP_0003311 aminoaciduria an accumulation of an intermediate of tryptophan catabolism in the urine http://purl.obolibrary.org/obo/MP_0002932 abnormal joint morphology http://purl.obolibrary.org/obo/MP_0005508 abnormal skeleton morphology any structural anomaly of the moveable articulation point of two or more bones http://purl.obolibrary.org/obo/MP_0002933 joint inflammation http://purl.obolibrary.org/obo/MP_0001846 increased inflammatory response local accumulation of fluid, plasma proteins, and leukocytes in the joints http://purl.obolibrary.org/obo/MP_0002934 acute joint inflammation http://purl.obolibrary.org/obo/MP_0002933 joint inflammation early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into the joints; initiated by injury, infection, or local immune response http://purl.obolibrary.org/obo/MP_0002935 chronic joint inflammation http://purl.obolibrary.org/obo/MP_0002933 joint inflammation persistent inflammatory response in the joints, often caused by persistent infection or during an autoimmune response http://purl.obolibrary.org/obo/MP_0002936 joint swelling http://purl.obolibrary.org/obo/MP_0002932 abnormal joint morphology enlargement of the joints, usually due to an accumulation of fluid http://purl.obolibrary.org/obo/MP_0002937 synovial hyperemia http://purl.obolibrary.org/obo/MP_0002932 abnormal joint morphology an increased blood flow to the a synovial joint http://purl.obolibrary.org/obo/MP_0002938 white spotting http://purl.obolibrary.org/obo/MP_0002075 abnormal coat/hair pigmentation the appearance of patches of white fur http://purl.obolibrary.org/obo/MP_0002939 head spot http://purl.obolibrary.org/obo/MP_0002938 white spotting the appearance of a round area of white fur on the head http://purl.obolibrary.org/obo/MP_0002940 variable body spotting http://purl.obolibrary.org/obo/MP_0002938 white spotting the appearance of patches of white fur at random on the coat http://purl.obolibrary.org/obo/MP_0002941 increased circulating alanine transaminase level http://purl.obolibrary.org/obo/MP_0001573 abnormal circulating alanine transaminase level increased concentration in the blood of the enzyme which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction http://purl.obolibrary.org/obo/MP_0002942 decreased circulating alanine transaminase level http://purl.obolibrary.org/obo/MP_0001573 abnormal circulating alanine transaminase level decreased concentration in the blood of the enzyme which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction http://purl.obolibrary.org/obo/MP_0002943 abnormal lactate dehydrogenase level http://purl.obolibrary.org/obo/MP_0005319 abnormal enzyme/ coenzyme level abnormal level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate http://purl.obolibrary.org/obo/MP_0002944 increased lactate dehydrogenase level http://purl.obolibrary.org/obo/MP_0002943 abnormal lactate dehydrogenase level elevated level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate http://purl.obolibrary.org/obo/MP_0002945 abnormal inhibitory postsynaptic currents http://purl.obolibrary.org/obo/MP_0002206 abnormal CNS synaptic transmission defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization http://purl.obolibrary.org/obo/MP_0002946 delayed axon extension http://purl.obolibrary.org/obo/MP_0003651 abnormal axon extension an increased amount of time required for an axon to extend from a neuron cell body and find the target http://purl.obolibrary.org/obo/MP_0002947 increased hemangioma incidence http://purl.obolibrary.org/obo/MP_0010291 increased cardiovascular system tumor incidence greater than the expected number of a benign tumor characterized by blood-filled spaces lined by benign endothelial cells, occurring in a specific population in a given time period; a cavernous hemangioma is characterized by large endothelial spaces (caverns), and a capillary hemangioma is characterized by small endothelial spaces http://purl.obolibrary.org/obo/MP_0002948 abnormal neuron specification http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology defects in the developmental patterning of neurons resulting in ectopic placement, decreased numbers or absence of mature neurons http://purl.obolibrary.org/obo/MP_0002950 abnormal neural crest cell migration http://purl.obolibrary.org/obo/MP_0012745 abnormal neural crest cell physiology any anomaly in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult http://purl.obolibrary.org/obo/MP_0002951 small thyroid gland http://purl.obolibrary.org/obo/MP_0000681 abnormal thyroid gland morphology reduced size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin http://purl.obolibrary.org/obo/MP_0002952 ventricular cardiomyopathy http://purl.obolibrary.org/obo/MP_0005330 cardiomyopathy diseases of the ventricles of the heart http://purl.obolibrary.org/obo/MP_0002953 thick ventricular wall http://purl.obolibrary.org/obo/MP_0020135 abnormal heart ventricle wall thickness increased depth of the cardiac wall of the heart ventricles http://purl.obolibrary.org/obo/MP_0002955 increased compensatory renal growth http://purl.obolibrary.org/obo/MP_0002706 abnormal kidney size increased additional growth of a kidney upon removal of the other kidney through surgery or disease http://purl.obolibrary.org/obo/MP_0002956 decreased compensatory renal growth http://purl.obolibrary.org/obo/MP_0002706 abnormal kidney size decreased additional growth of a kidney upon removal of the other kidney through surgery or disease http://purl.obolibrary.org/obo/MP_0002957 increased intestinal adenocarcinoma incidence http://purl.obolibrary.org/obo/MP_0010279 increased gastrointestinal tumor incidence higher than normal incidence of a malignant neoplasm of epithelial cells in the intestine http://purl.obolibrary.org/obo/MP_0002958 cerebral aqueductal stenosis http://purl.obolibrary.org/obo/MP_0005537 abnormal cerebral aqueduct morphology the most common form of obstructive hydrocephaly and results from narrowing of the aqueduct of Sylvius, which connects the third and fourth ventricles http://purl.obolibrary.org/obo/MP_0002959 increased urine microalbumin level http://purl.obolibrary.org/obo/MP_0002962 increased urine protein level greater than the normal amount of microalbumin in the urine http://purl.obolibrary.org/obo/MP_0002960 decreased urine microalbumin level http://purl.obolibrary.org/obo/MP_0002963 decreased urine protein level less than the normal amount of microalbumin in the urine http://purl.obolibrary.org/obo/MP_0002961 abnormal axon guidance http://purl.obolibrary.org/obo/MP_0009937 abnormal neuron differentiation defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues http://purl.obolibrary.org/obo/MP_0002962 increased urine protein level http://purl.obolibrary.org/obo/MP_0006315 abnormal urine protein level greater than the normal amount of proteins in the urine http://purl.obolibrary.org/obo/MP_0002963 decreased urine protein level http://purl.obolibrary.org/obo/MP_0006315 abnormal urine protein level less than the normal amount of proteins in the urine http://purl.obolibrary.org/obo/MP_0002964 aortic elastic tissue lesions http://purl.obolibrary.org/obo/MP_0009862 abnormal aorta elastic tissue morphology focal pathological changes in the elastic lamella of the muscular layer of the main trunk of the arterial system http://purl.obolibrary.org/obo/MP_0002965 increased circulating serum albumin level http://purl.obolibrary.org/obo/MP_0000199 abnormal circulating serum albumin level blood serum albumin concentration above the normal range http://purl.obolibrary.org/obo/MP_0002966 decreased circulating alkaline phosphatase level http://purl.obolibrary.org/obo/MP_0000202 abnormal circulating alkaline phosphatase level reduced concentration in the blood of the enzyme which hydrolyzes orthophosphoric monoesters http://purl.obolibrary.org/obo/MP_0002968 increased circulating alkaline phosphatase level http://purl.obolibrary.org/obo/MP_0000202 abnormal circulating alkaline phosphatase level elevated concentration in the blood of the enzyme which hydrolyzes orthophosphoric monoesters http://purl.obolibrary.org/obo/MP_0002969 impaired social transmission of food preference http://purl.obolibrary.org/obo/MP_0012296 impaired discrimination learning defect in the ability to recall and prefer foods associated with odors recently smelled on the breath of other mice; an indicator of defects in learning and memory of olfactory cues http://purl.obolibrary.org/obo/MP_0002970 abnormal white adipose tissue morphology http://purl.obolibrary.org/obo/MP_0000003 abnormal adipose tissue morphology any structural anomaly of the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels http://purl.obolibrary.org/obo/MP_0002971 abnormal brown adipose tissue morphology http://purl.obolibrary.org/obo/MP_0000003 abnormal adipose tissue morphology any structural anomaly of the thermogenic form of adipose tissue that is composed of brown adipocytes http://purl.obolibrary.org/obo/MP_0002972 abnormal cardiac muscle contractility http://purl.obolibrary.org/obo/MP_0005620 abnormal muscle contractility altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max, fractional shortening (FS), velocity of circumferential fiber shortening (Vcfc), peak of aortic outflow velocity (PAV), and ventricular ejection fraction volume http://purl.obolibrary.org/obo/MP_0002975 vascular smooth muscle hypertrophy http://purl.obolibrary.org/obo/MP_0005592 abnormal vascular smooth muscle morphology increase in size or thickness of the smooth muscle of the vascular wall http://purl.obolibrary.org/obo/MP_0002976 vascular smooth muscle hypotrophy http://purl.obolibrary.org/obo/MP_0005592 abnormal vascular smooth muscle morphology decrease in size or thickness of the smooth muscle of the vascular wall http://purl.obolibrary.org/obo/MP_0002978 absent otoliths http://purl.obolibrary.org/obo/MP_0002894 abnormal otolith morphology absence of the crystalline calciferous particles adhering to the otolithic membrane http://purl.obolibrary.org/obo/MP_0002980 abnormal postural reflex http://purl.obolibrary.org/obo/MP_0001961 abnormal reflex any anomaly in the responses that control the normal position of the trunk and extremities and/or posture http://purl.obolibrary.org/obo/MP_0002981 increased liver weight http://purl.obolibrary.org/obo/MP_0004847 abnormal liver weight a greater than average weight of the bile-secreting exocrine gland http://purl.obolibrary.org/obo/MP_0002982 abnormal primordial germ cell migration http://purl.obolibrary.org/obo/MP_0003091 abnormal cell migration any anomaly in the orderly movement of a primordial germ cell, a cell specialized to produce haploid gametes, from one site to another during development http://purl.obolibrary.org/obo/MP_0002983 increased retinal ganglion cell number http://purl.obolibrary.org/obo/MP_0008056 abnormal retinal ganglion cell morphology greater number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain http://purl.obolibrary.org/obo/MP_0002984 retina hypoplasia http://purl.obolibrary.org/obo/MP_0001325 abnormal retina morphology underdevelopment or reduced size, usually due to a reduced number of cells, in the thin layer of neural tissue lining the back of the eyeball which contains visual receptors http://purl.obolibrary.org/obo/MP_0002985 abnormal urine calcium level http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis any change in the amount of calcium in the urine http://purl.obolibrary.org/obo/MP_0002986 decreased urine calcium level http://purl.obolibrary.org/obo/MP_0002985 abnormal urine calcium level abnormally low amounts of calcium in the urine http://purl.obolibrary.org/obo/MP_0002987 abnormal urine osmolality http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis changes in the amount of ions in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0002988 decreased urine osmolality http://purl.obolibrary.org/obo/MP_0002987 abnormal urine osmolality reduction in the amount of ions in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0002989 small kidney http://purl.obolibrary.org/obo/MP_0002706 abnormal kidney size reduced physical bulk one or both of the organs responsible for urine secretion http://purl.obolibrary.org/obo/MP_0002990 short ureter http://purl.obolibrary.org/obo/MP_0000534 abnormal ureter morphology reduced length of the tube that conducts the urine from the renal pelvis to the bladder http://purl.obolibrary.org/obo/MP_0002991 abnormal sebaceous gland physiology http://purl.obolibrary.org/obo/MP_0010680 abnormal skin adnexa physiology any functional anomaly of the holocrine glands that secrete sebum into the hair follicles or in hairless areas into ducts http://purl.obolibrary.org/obo/MP_0002992 abnormal sebaceous lipid secretion http://purl.obolibrary.org/obo/MP_0002991 abnormal sebaceous gland physiology abnormal function of the sebaceous gland resulting in changes to the lipid profile secreted onto the hair and skin http://purl.obolibrary.org/obo/MP_0002993 arthritis http://purl.obolibrary.org/obo/MP_0002933 joint inflammation autoimmune joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures http://purl.obolibrary.org/obo/MP_0002995 primary sex reversal http://purl.obolibrary.org/obo/MP_0005652 sex reversal gonad type is not consistent with chromosomal sex http://purl.obolibrary.org/obo/MP_0002996 ovotestis http://purl.obolibrary.org/obo/MP_0003936 abnormal reproductive system development state in which a single recognizable gonad contains both testicular and ovarian tissue http://purl.obolibrary.org/obo/MP_0002997 enlarged seminal vesicle http://purl.obolibrary.org/obo/MP_0004907 abnormal seminal vesicle size increased size of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens http://purl.obolibrary.org/obo/MP_0002998 abnormal bone remodeling http://purl.obolibrary.org/obo/MP_0001533 abnormal skeleton physiology aberrant process of the continuous turnover of bone matrix and mineral that involves a balance of resorption and reactive bone formation by osteoclasts and osteoblasts, respectively http://purl.obolibrary.org/obo/MP_0002999 abnormal bone healing http://purl.obolibrary.org/obo/MP_0005023 abnormal wound healing defects in the restoration of integrity to bone after trauma http://purl.obolibrary.org/obo/MP_0003005 abnormal hippocampal fimbria morphology http://purl.obolibrary.org/obo/MP_0000807 abnormal hippocampus morphology any structural anomaly of the flattened band of efferent fibers arising from the subiculum and medial border of the hippocampus, which then thickens to form the fornix and fibers of the hippocampal commissure http://purl.obolibrary.org/obo/MP_0003006 abnormal hippocampal fornix morphology http://purl.obolibrary.org/obo/MP_0000807 abnormal hippocampus morphology any structural anomaly of the compact, white, heavily myelinated fiber bundle arising from the Ammon horn of the hippocampus in each cerebral hemisphere and projecting to the hypothalamus and the mammillary body http://purl.obolibrary.org/obo/MP_0003007 ectopic thymus http://purl.obolibrary.org/obo/MP_0000703 abnormal thymus morphology ectopic location of the thymus primordium, which normally resides in the superior mediastinum and lower part of the neck http://purl.obolibrary.org/obo/MP_0003008 enhanced long term potentiation http://purl.obolibrary.org/obo/MP_0002207 abnormal long term potentiation greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells http://purl.obolibrary.org/obo/MP_0003009 abnormal cytokine secretion http://purl.obolibrary.org/obo/MP_0002723 abnormal immune serum protein physiology anomaly in the production or cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells http://purl.obolibrary.org/obo/MP_0003010 decreased mortality induced by ionizing radiation http://purl.obolibrary.org/obo/MP_0020149 abnormal mortality induced by ionizing radiation reduced sensitivity to lethal doses of ionizing radiation such as ultraviolet light, X-rays, or gamma rays http://purl.obolibrary.org/obo/MP_0003011 delayed dark adaptation http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology increase in time required for the eye to recover its sensitivity in the dark following exposure to bright lights http://purl.obolibrary.org/obo/MP_0003012 no phenotypic analysis http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype no description of morphological, physiological or behavioral information presented http://purl.obolibrary.org/obo/MP_0003014 abnormal kidney medulla morphology http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology any structural anomaly of the inner portion of the kidney consisting of the renal pyramids http://purl.obolibrary.org/obo/MP_0003015 abnormal circulating bicarbonate level http://purl.obolibrary.org/obo/MP_0009642 abnormal blood homeostasis aberrant concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood http://purl.obolibrary.org/obo/MP_0003016 increased circulating bicarbonate level http://purl.obolibrary.org/obo/MP_0003015 abnormal circulating bicarbonate level elevated concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood http://purl.obolibrary.org/obo/MP_0003017 decreased circulating bicarbonate level http://purl.obolibrary.org/obo/MP_0003015 abnormal circulating bicarbonate level reduced concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood http://purl.obolibrary.org/obo/MP_0003018 abnormal circulating chloride level http://purl.obolibrary.org/obo/MP_0012007 abnormal chloride level aberrant concentration of chlorine salts in the circulation http://purl.obolibrary.org/obo/MP_0003019 increased circulating chloride level http://purl.obolibrary.org/obo/MP_0003018 abnormal circulating chloride level elevated concentration of chlorine salts in the circulation http://purl.obolibrary.org/obo/MP_0003020 decreased circulating chloride level http://purl.obolibrary.org/obo/MP_0003018 abnormal circulating chloride level reduced concentration of chlorine salts in the circulation http://purl.obolibrary.org/obo/MP_0003021 abnormal coronary flow rate http://purl.obolibrary.org/obo/MP_0006111 abnormal coronary circulation aberrant rate of blood flow in the blood vessels supplying the heart http://purl.obolibrary.org/obo/MP_0003022 increased coronary flow rate http://purl.obolibrary.org/obo/MP_0003021 abnormal coronary flow rate elevated rate of blood flow in the blood vessels supplying the heart http://purl.obolibrary.org/obo/MP_0003023 decreased coronary flow rate http://purl.obolibrary.org/obo/MP_0003021 abnormal coronary flow rate reduced rate of blood flow in the blood vessels supplying the heart http://purl.obolibrary.org/obo/MP_0003024 coronary artery stenosis http://purl.obolibrary.org/obo/MP_0006135 artery stenosis constriction or narrowing of any of the blood vessels supplying the heart http://purl.obolibrary.org/obo/MP_0003025 increased vasoconstriction http://purl.obolibrary.org/obo/MP_0000250 abnormal vasoconstriction greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels http://purl.obolibrary.org/obo/MP_0003026 decreased vasoconstriction http://purl.obolibrary.org/obo/MP_0000740 impaired smooth muscle contractility reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels http://purl.obolibrary.org/obo/MP_0003027 abnormal blood pH regulation http://purl.obolibrary.org/obo/MP_0009642 abnormal blood homeostasis anomaly in the function of the buffer systems of the blood in combination with the respiratory and renal systems that control the relative acidity or alkalinity of the blood, as measured by the concentration of the hydrogen ion http://purl.obolibrary.org/obo/MP_0003028 alkalosis http://purl.obolibrary.org/obo/MP_0004043 abnormal pH regulation a pathological condition characterized by a decrease in the hydrogen ion concentration in tissues and in blood; caused by an increase in the concentration of alkaline compounds, or by a decrease in the concentration of acidic compounds or carbon dioxide to the body fluids http://purl.obolibrary.org/obo/MP_0003029 alkalemia http://purl.obolibrary.org/obo/MP_0003027 abnormal blood pH regulation decreased concentration of H-ion in the blood or a rise in pH in the arterial blood http://purl.obolibrary.org/obo/MP_0003030 acidemia http://purl.obolibrary.org/obo/MP_0003027 abnormal blood pH regulation increased concentration of H-ion in the blood or a fall below normal in pH in the arterial blood http://purl.obolibrary.org/obo/MP_0003031 acidosis http://purl.obolibrary.org/obo/MP_0004043 abnormal pH regulation a pathological state characterized by an increase in the hydrogen ion concentration in tissues and blood caused by an decrease in the concentration of alkaline compounds, or by a increase in the concentration of acidic compounds or carbon dioxide to the body fluids http://purl.obolibrary.org/obo/MP_0003032 hypocapnia http://purl.obolibrary.org/obo/MP_0003860 abnormal carbon dioxide level reduced concentration of CO2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases http://purl.obolibrary.org/obo/MP_0003033 abnormal pulmonary vascular resistance http://purl.obolibrary.org/obo/MP_0005532 abnormal vascular resistance deviation from the normal force opposing blood flow in the lung blood vessels http://purl.obolibrary.org/obo/MP_0003034 increased pulmonary vascular resistance http://purl.obolibrary.org/obo/MP_0003033 abnormal pulmonary vascular resistance greater than the normal force opposing blood flow in the lung blood vessels http://purl.obolibrary.org/obo/MP_0003035 decreased pulmonary vascular resistance http://purl.obolibrary.org/obo/MP_0003033 abnormal pulmonary vascular resistance less than the normal force opposing blood flow in the lung blood vessels http://purl.obolibrary.org/obo/MP_0003036 vertebral transformation http://purl.obolibrary.org/obo/MP_0000137 abnormal vertebrae morphology homeotic transformation of a specific vertebrae to adopt the fate of another http://purl.obolibrary.org/obo/MP_0003037 increased myocardial infarction size http://purl.obolibrary.org/obo/MP_0000343 altered response to myocardial infarction increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors http://purl.obolibrary.org/obo/MP_0003038 decreased myocardial infarction size http://purl.obolibrary.org/obo/MP_0000343 altered response to myocardial infarction decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors http://purl.obolibrary.org/obo/MP_0003039 increased time of peak ischemic contracture http://purl.obolibrary.org/obo/MP_0000343 altered response to myocardial infarction increased duration of time from normal necessary to achieve full irreversible contraction of the cardiac muscle in response to myocardial infarction http://purl.obolibrary.org/obo/MP_0003040 decreased time of peak ischemic contracture http://purl.obolibrary.org/obo/MP_0000343 altered response to myocardial infarction decreased duration of time from normal necessary to achieve full irreversible contraction of the cardiac muscle in response to myocardial infarction http://purl.obolibrary.org/obo/MP_0003041 increased time of onset of induced ischemic contracture http://purl.obolibrary.org/obo/MP_0000343 altered response to myocardial infarction increased duration of time from normal necessary to initiate the irreversible contraction of the cardiac muscle in response to induced myocardial infarction http://purl.obolibrary.org/obo/MP_0003042 decreased time of onset of induced ischemic contracture http://purl.obolibrary.org/obo/MP_0000343 altered response to myocardial infarction decreased duration of time from normal necessary to initiate the irreversible contraction of the cardiac muscle in response to induced myocardial infarction http://purl.obolibrary.org/obo/MP_0003043 hypoalgesia http://purl.obolibrary.org/obo/MP_0001970 abnormal pain threshold decreased sensitivity to painful stimuli; can be due to chemical intervention, neuropathies or due to damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area) http://purl.obolibrary.org/obo/MP_0003044 impaired basement membrane formation http://purl.obolibrary.org/obo/MP_0004272 abnormal basement membrane morphology defect in the development of the extracellular supportive tissue closely adjacent to the basal surface of the epithelium of muscle cells, fat cells and Schwann cells, which is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components http://purl.obolibrary.org/obo/MP_0003046 liver cirrhosis http://purl.obolibrary.org/obo/MP_0000598 abnormal liver morphology liver disease in which the occurrence of fibrotic nodules cause diffuse damage to parenchymal cells, disruptions in microcirculation, vascular anatomy and hepatic architecture, resulting in hepatic dysfunction and ultimately, hepatic failure http://purl.obolibrary.org/obo/MP_0003047 abnormal thoracic vertebrae morphology http://purl.obolibrary.org/obo/MP_0004624 abnormal thoracic cage morphology any structural anomaly of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae http://purl.obolibrary.org/obo/MP_0003048 abnormal cervical vertebrae morphology http://purl.obolibrary.org/obo/MP_0000459 abnormal presacral vertebrae morphology any structural anomaly of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae and caudal to the skull http://purl.obolibrary.org/obo/MP_0003049 abnormal lumbar vertebrae morphology http://purl.obolibrary.org/obo/MP_0000459 abnormal presacral vertebrae morphology any structural anomaly of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae http://purl.obolibrary.org/obo/MP_0003050 abnormal sacral vertebrae morphology http://purl.obolibrary.org/obo/MP_0000137 abnormal vertebrae morphology any structural anomaly of any or all of the bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae http://purl.obolibrary.org/obo/MP_0003051 curly tail http://purl.obolibrary.org/obo/MP_0002111 abnormal tail morphology a loop or corkscrew-like curl in the tail http://purl.obolibrary.org/obo/MP_0003052 omphalocele http://purl.obolibrary.org/obo/MP_0003257 abnormal abdominal wall morphology protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion, that is caused by a severe body wall defect http://purl.obolibrary.org/obo/MP_0003053 delayed tooth eruption http://purl.obolibrary.org/obo/MP_0000119 abnormal tooth eruption postponed onset of the growth of the teeth out of the gums http://purl.obolibrary.org/obo/MP_0003054 spina bifida http://purl.obolibrary.org/obo/MP_0000929 open neural tube common congenital midline defect of fusion of the vertebral arch http://purl.obolibrary.org/obo/MP_0003055 abnormal long bone epiphyseal plate morphology http://purl.obolibrary.org/obo/MP_0006395 abnormal epiphyseal plate morphology any structural anomaly of the cartilaginous center of ossification located at one or both ends of bones between the epiphysis (end) and the diaphysis (shaft) of long bones; longitudinal growth of the bone occurs at the plate during development in children and juveniles http://purl.obolibrary.org/obo/MP_0003056 abnormal hyoid bone morphology http://purl.obolibrary.org/obo/MP_0005274 abnormal viscerocranium morphology any structural anomaly of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles http://purl.obolibrary.org/obo/MP_0003057 abnormal epicardium morphology http://purl.obolibrary.org/obo/MP_0000288 abnormal pericardium morphology any structural anomaly of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart http://purl.obolibrary.org/obo/MP_0003058 increased insulin secretion http://purl.obolibrary.org/obo/MP_0003564 abnormal insulin secretion greater production or release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids http://purl.obolibrary.org/obo/MP_0003059 decreased insulin secretion http://purl.obolibrary.org/obo/MP_0003564 abnormal insulin secretion reduction in the production or release of the hormone secreted by beta cells of the pancreas that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids http://purl.obolibrary.org/obo/MP_0003060 increased aerobic running capacity http://purl.obolibrary.org/obo/MP_0012107 enhanced exercise endurance greater ability to run at defined speeds and/or distances compared to controls http://purl.obolibrary.org/obo/MP_0003061 decreased aerobic running capacity http://purl.obolibrary.org/obo/MP_0012106 impaired exercise endurance reduced ability to run at defined speeds and/or distances compared to controls http://purl.obolibrary.org/obo/MP_0003062 abnormal coping response http://purl.obolibrary.org/obo/MP_0003360 abnormal depression-related behavior altered ability to respond productively to a stressful situation or stimulus, or failure to seek pleasurable stimuli http://purl.obolibrary.org/obo/MP_0003063 increased coping response http://purl.obolibrary.org/obo/MP_0003062 abnormal coping response enhanced ability to respond productively to a stressful situation http://purl.obolibrary.org/obo/MP_0003064 decreased coping response http://purl.obolibrary.org/obo/MP_0003062 abnormal coping response reduced ability to respond productively to a stressful situation http://purl.obolibrary.org/obo/MP_0003065 abnormal liver copper level http://purl.obolibrary.org/obo/MP_0003952 abnormal copper level anomaly in the amount of copper present in the liver tissue http://purl.obolibrary.org/obo/MP_0003066 increased liver copper level http://purl.obolibrary.org/obo/MP_0003065 abnormal liver copper level a greater accumulation of copper in the liver tissue compared to controls http://purl.obolibrary.org/obo/MP_0003067 decreased liver copper level http://purl.obolibrary.org/obo/MP_0003065 abnormal liver copper level a reduced amount of copper in the liver tissue compared to controls http://purl.obolibrary.org/obo/MP_0003068 enlarged kidney http://purl.obolibrary.org/obo/MP_0002706 abnormal kidney size larger than average size of the kidney http://purl.obolibrary.org/obo/MP_0003069 abnormal superior semicircular canal morphology http://purl.obolibrary.org/obo/MP_0002428 abnormal semicircular canal morphology any structural anomaly of the upper, superior segment of the long bony tube of the labyrinth that is involved in the sense of balance http://purl.obolibrary.org/obo/MP_0003070 increased vascular permeability http://purl.obolibrary.org/obo/MP_0001619 abnormal vascular permeability greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases http://purl.obolibrary.org/obo/MP_0003071 decreased vascular permeability http://purl.obolibrary.org/obo/MP_0001619 abnormal vascular permeability reduced or slower ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases http://purl.obolibrary.org/obo/MP_0003072 abnormal metatarsal bone morphology http://purl.obolibrary.org/obo/MP_0011504 abnormal limb long bone morphology any structural anomaly in the five bones of the hindpaws/feet that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges http://purl.obolibrary.org/obo/MP_0003073 abnormal metacarpal bone morphology http://purl.obolibrary.org/obo/MP_0011504 abnormal limb long bone morphology any structural anomaly in the five bones of the forepaws/hands that articulate proximally with the carpal bones and distally with the phalanges http://purl.obolibrary.org/obo/MP_0003074 absent metacarpal bones http://purl.obolibrary.org/obo/MP_0003073 abnormal metacarpal bone morphology missing all of the five bones of the forepaws/hands that articulate proximally with the carpal bones and distally with the phalanges http://purl.obolibrary.org/obo/MP_0003075 altered response to CNS ischemic injury http://purl.obolibrary.org/obo/MP_0005164 abnormal response to injury altered response to lack of adequate blood flow, due to trauma or disease, to support the normal functioning of a tissue in the central nervous system http://purl.obolibrary.org/obo/MP_0003076 increased susceptibility to ischemic brain injury http://purl.obolibrary.org/obo/MP_0005165 increased susceptibility to injury increased frequency or more severe response, such as necrotic tissue size, to lack of adequate blood flow, due to trauma or disease, to support the normal functioning of all or part of the brain tissue, compared to controls http://purl.obolibrary.org/obo/MP_0003077 abnormal cell cycle http://purl.obolibrary.org/obo/MP_0005621 abnormal cell physiology failure to progress or abnormal progression through the stages of the cell cycle http://purl.obolibrary.org/obo/MP_0003078 aphakia http://purl.obolibrary.org/obo/MP_0001303 abnormal lens morphology absence of the crystalline lens of the eye http://purl.obolibrary.org/obo/MP_0003079 decreased susceptibility to induced joint inflammation http://purl.obolibrary.org/obo/MP_0002933 joint inflammation reduced or absent inflammatory response in the joints due to chemical or mechanical agents http://purl.obolibrary.org/obo/MP_0003080 increased natural killer cell mediated cytotoxicity http://purl.obolibrary.org/obo/MP_0011719 abnormal natural killer cell mediated cytotoxicity increased ability of directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors http://purl.obolibrary.org/obo/MP_0003081 abnormal soleus morphology http://purl.obolibrary.org/obo/MP_0003358 abnormal hypaxial muscle morphology any structural anomaly of the superficial flat broad muscle of the calf that is responsible for plantar flexion of the foot http://purl.obolibrary.org/obo/MP_0003082 abnormal gastrocnemius morphology http://purl.obolibrary.org/obo/MP_0003358 abnormal hypaxial muscle morphology any structural anomaly of the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles http://purl.obolibrary.org/obo/MP_0003083 abnormal tibialis anterior morphology http://purl.obolibrary.org/obo/MP_0003358 abnormal hypaxial muscle morphology any structural anomaly of the muscle of the shin that is responsible for dorsiflexion and inversion of the foot http://purl.obolibrary.org/obo/MP_0003084 abnormal skeletal muscle fiber morphology http://purl.obolibrary.org/obo/MP_0004087 abnormal muscle fiber morphology any structural anomaly of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles http://purl.obolibrary.org/obo/MP_0003085 abnormal egg cylinder morphology http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology any structural anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells http://purl.obolibrary.org/obo/MP_0003086 hydromyelia http://purl.obolibrary.org/obo/MP_0000955 abnormal spinal cord morphology increased fluid in the central canal of the spinal cord http://purl.obolibrary.org/obo/MP_0003087 absent allantois http://purl.obolibrary.org/obo/MP_0001726 abnormal allantois morphology missing fetal membrane which contributes to the formation of the umbilical cord and placenta http://purl.obolibrary.org/obo/MP_0003088 abnormal prepulse inhibition http://purl.obolibrary.org/obo/MP_0002206 abnormal CNS synaptic transmission anomaly in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus http://purl.obolibrary.org/obo/MP_0003089 decreased skin tensile strength http://purl.obolibrary.org/obo/MP_0005275 abnormal skin tensile strength reduction in the normal maximum tension the skin can withstand without tearing http://purl.obolibrary.org/obo/MP_0003090 abnormal muscle precursor cell migration http://purl.obolibrary.org/obo/MP_0012186 abnormal muscle precursor cell physiology defects in the movement of cells that will develop into muscle cells out of the somites and/or to the appropriate location in the body http://purl.obolibrary.org/obo/MP_0003091 abnormal cell migration http://purl.obolibrary.org/obo/MP_0005621 abnormal cell physiology any anomaly in the movement of cells from one site to another, often occurring during developmental or chemotactic processes http://purl.obolibrary.org/obo/MP_0003092 decreased corneal stroma thickness http://purl.obolibrary.org/obo/MP_0005543 decreased cornea thickness reduced width of the lamellated connective tissue layer of the cornea http://purl.obolibrary.org/obo/MP_0003093 abnormal anterior stroma morphology http://purl.obolibrary.org/obo/MP_0005300 abnormal corneal stroma morphology any structural anomaly of the anterior segment of the lamellated connective tissue layer of the cornea http://purl.obolibrary.org/obo/MP_0003094 abnormal posterior stroma morphology http://purl.obolibrary.org/obo/MP_0005300 abnormal corneal stroma morphology any structural anomaly of the posterior segment of the lamellated connective tissue layer of the cornea http://purl.obolibrary.org/obo/MP_0003095 abnormal corneal stroma development http://purl.obolibrary.org/obo/MP_0005300 abnormal corneal stroma morphology anomalous differentiation of the lamellated connective tissue layer of the cornea http://purl.obolibrary.org/obo/MP_0003096 increased corneal light-scattering http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology anomaly in the normal transmission of light through the cornea; light is reflected or absorbed instead; often due to anomalies in the arrangement of lamella in the corneal stroma http://purl.obolibrary.org/obo/MP_0003097 abnormal tendon stiffness http://purl.obolibrary.org/obo/MP_0002106 abnormal muscle physiology altered ability of tendon to maintain tensile strength and load http://purl.obolibrary.org/obo/MP_0003098 decreased tendon stiffness http://purl.obolibrary.org/obo/MP_0003097 abnormal tendon stiffness reduced ability of tendon to maintain tensile strength and load http://purl.obolibrary.org/obo/MP_0003099 retinal detachment http://purl.obolibrary.org/obo/MP_0001325 abnormal retina morphology detachment of the retina from the underlying inner wall of the eye, often from tension of the vitreous; may occur with aging or as a result of trauma http://purl.obolibrary.org/obo/MP_0003100 myopia http://purl.obolibrary.org/obo/MP_0002090 abnormal vision optical condition in which only rays from a finite distance from the eye focus on the retina http://purl.obolibrary.org/obo/MP_0003101 high myopia http://purl.obolibrary.org/obo/MP_0003100 myopia an optical condition involving enlarging of the eye, scleral thinning and frequent detachment of the retina resulting from stress associated with excessive axial elongation http://purl.obolibrary.org/obo/MP_0003102 sclera thinning http://purl.obolibrary.org/obo/MP_0002698 abnormal sclera morphology reduction in the width of the fibrous, outer envelope of the eyeball, the sclera may appear blue as a result of the underlying epithelium showing through http://purl.obolibrary.org/obo/MP_0003103 liver degeneration http://purl.obolibrary.org/obo/MP_0000598 abnormal liver morphology deterioration of the liver due to injury or disease, often accompanied by loss of function http://purl.obolibrary.org/obo/MP_0003104 acrania http://purl.obolibrary.org/obo/MP_0000438 abnormal cranium morphology complete or partial absence of a skull; usually associated with anencephaly http://purl.obolibrary.org/obo/MP_0003105 abnormal heart atrium morphology http://purl.obolibrary.org/obo/MP_0000266 abnormal heart morphology any structural anomaly of one or both of the two upper chambers of the heart, to which the blood returns from the circulation http://purl.obolibrary.org/obo/MP_0003106 abnormal fear-related response http://purl.obolibrary.org/obo/MP_0002065 abnormal fear/anxiety-related behavior altered emotional response related to anticipation of specific pain or danger http://purl.obolibrary.org/obo/MP_0003107 abnormal response to novelty http://purl.obolibrary.org/obo/MP_0002572 abnormal emotion/affect behavior alteration in amount of exploration/investigation of a novel object, situation or environment http://purl.obolibrary.org/obo/MP_0003108 short zygomatic bone http://purl.obolibrary.org/obo/MP_0004468 small zygomatic bone reduced length of the bone that forms the prominence of the cheek http://purl.obolibrary.org/obo/MP_0003109 short femur http://purl.obolibrary.org/obo/MP_0004686 decreased length of long bones reduced length of the long bone of the thigh http://purl.obolibrary.org/obo/MP_0003110 absent malleus processus brevis http://purl.obolibrary.org/obo/MP_0010324 abnormal malleus processus brevis morphology absence of the short projection extending from the base of the manubrium of the malleus which contacts the upper part of the tympanic membrane where the tympanic cavity makes a deep pocket (epitympanic pocket) surrounding the cartilaginous nodule http://purl.obolibrary.org/obo/MP_0003111 abnormal cell nucleus morphology http://purl.obolibrary.org/obo/MP_0000358 abnormal cell morphology any structural anomaly of a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated; in most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing, but in some species, or in specialized cell types, RNA metabolism or DNA replication may be absent http://purl.obolibrary.org/obo/MP_0003112 enlarged parathyroid gland http://purl.obolibrary.org/obo/MP_0000678 abnormal parathyroid gland morphology increased size of the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; they secrete parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism http://purl.obolibrary.org/obo/MP_0003113 small parathyroid gland http://purl.obolibrary.org/obo/MP_0000678 abnormal parathyroid gland morphology decreased size of the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; they secrete parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism http://purl.obolibrary.org/obo/MP_0003114 pigmented parathyroid gland http://purl.obolibrary.org/obo/MP_0000678 abnormal parathyroid gland morphology presence of melanocytes and/or melanin in either of the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; they secrete parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism http://purl.obolibrary.org/obo/MP_0003115 abnormal respiratory system development http://purl.obolibrary.org/obo/MP_0002132 abnormal respiratory system morphology aberrant differentiation of pulmonary tissues http://purl.obolibrary.org/obo/MP_0003116 rickets http://purl.obolibrary.org/obo/MP_0002896 abnormal bone mineralization overproduction and deficient calcification of osteoid tissue due to vitamin D deficiency; can lead to skeletal deformities, growth defects, hypocalcemia, and sometimes tetany; skeletal fractures occur frequently http://purl.obolibrary.org/obo/MP_0003119 abnormal digestive system development http://purl.obolibrary.org/obo/MP_0000462 abnormal digestive system morphology abnormal formation of the organ system that converts ingested food to nutrients and energy http://purl.obolibrary.org/obo/MP_0003120 abnormal tracheal cartilage morphology http://purl.obolibrary.org/obo/MP_0002282 abnormal trachea morphology any structural anomaly of the cartilaginous structures that support the trachea http://purl.obolibrary.org/obo/MP_0003121 genetic imprinting http://purl.obolibrary.org/obo/MP_0005384 cellular phenotype any anomaly in the process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules by a mechanism that is mediated by DNA, is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence http://purl.obolibrary.org/obo/MP_0003122 maternal imprinting http://purl.obolibrary.org/obo/MP_0012167 abnormal epigenetic regulation of gene expression the establishment of heritable alterations in the activity of a gene that depend on whether it passed through the maternal germline, but that are not encoded by DNA itself http://purl.obolibrary.org/obo/MP_0003123 paternal imprinting http://purl.obolibrary.org/obo/MP_0012167 abnormal epigenetic regulation of gene expression establishment of heritable alterations in the activity of a gene that depend on whether it passed through the paternal germline, but that are not encoded by DNA itself http://purl.obolibrary.org/obo/MP_0003124 hypospadia http://purl.obolibrary.org/obo/MP_0011796 abnormal external urethral orifice morphology a urethral opening located below the normal location; in males, the opening is usually on the ventral surface of the penis, and in females, the opening is usually in the vagina http://purl.obolibrary.org/obo/MP_0003125 abnormal septation of the cloaca http://purl.obolibrary.org/obo/MP_0010115 abnormal embryonic cloaca morphology absence of or reduction in the separation of the single opening of the digestive, urinary, and reproductive tracts (cloaca) into multiple isolated openings during development, may result in hypospadia, reduced anogenital distance, or persistent cloaca http://purl.obolibrary.org/obo/MP_0003126 abnormal external female genitalia morphology http://purl.obolibrary.org/obo/MP_0009208 abnormal female genitalia morphology any structural anomaly of the external feminine genital organs, collectively known as the vulva and composed of the mons pubis, the labia majora and minora, the clitoris, the vestibule of the vagina and its glands, and the opening of the urethra and of the vagina http://purl.obolibrary.org/obo/MP_0003127 abnormal clitoris morphology http://purl.obolibrary.org/obo/MP_0003126 abnormal external female genitalia morphology any structural anomaly of the small, erectile body located at the anterior end of the vulva http://purl.obolibrary.org/obo/MP_0003128 splayed clitoris http://purl.obolibrary.org/obo/MP_0003127 abnormal clitoris morphology flattened or spread out clitoris http://purl.obolibrary.org/obo/MP_0003129 persistent cloaca http://purl.obolibrary.org/obo/MP_0003936 abnormal reproductive system development persistence of an early embryonic state in which the urinary, genital, and gastrointestinal tracts remain confluent and communicate with the exterior through a single perineal opening; due to failure of the urogenital septum to divide the embryonic cloaca into rectal and urogenital portions http://purl.obolibrary.org/obo/MP_0003130 anal atresia http://purl.obolibrary.org/obo/MP_0005034 abnormal anus morphology congenital absence of an anal opening due to the persistence of the epithelial plug (persistence of the anal membrane) or to complete absence of the anal canal http://purl.obolibrary.org/obo/MP_0003131 increased erythrocyte cell number http://purl.obolibrary.org/obo/MP_0011181 increased hematopoietic cell number greater number of the cells that transport oxygen, red blood cells, per unit http://purl.obolibrary.org/obo/MP_0003132 increased pre-B cell number http://purl.obolibrary.org/obo/MP_0005014 increased B cell number greater number of progenitor cells that form the B cell component of the immune system http://purl.obolibrary.org/obo/MP_0003133 increased early pro-B cell number http://purl.obolibrary.org/obo/MP_0008186 increased pro-B cell number greater number of cells in the B lymphocyte lineage that undergo D-J rearrangement of the immunoglobulin heavy chain http://purl.obolibrary.org/obo/MP_0003134 increased late pro-B cell number http://purl.obolibrary.org/obo/MP_0008186 increased pro-B cell number greater number of the cells in the B lymphocyte lineage that undergo V-DJ rearrangement of the immunoglobulin heavy chain http://purl.obolibrary.org/obo/MP_0003135 increased erythroid progenitor cell number http://purl.obolibrary.org/obo/MP_0008801 abnormal erythroid progenitor cell morphology greater numbers of progenitors of the erythrocyte lineage http://purl.obolibrary.org/obo/MP_0003136 yellow coat color http://purl.obolibrary.org/obo/MP_0012076 abnormal agouti pigmentation amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is maximally increased in agouti hair http://purl.obolibrary.org/obo/MP_0003137 abnormal impulse conducting system conduction http://purl.obolibrary.org/obo/MP_0001544 abnormal cardiovascular system physiology any functional anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart http://purl.obolibrary.org/obo/MP_0003138 absent tympanic ring http://purl.obolibrary.org/obo/MP_0000030 abnormal tympanic ring morphology missing the bony ring at the ear canal to which the tympanic membrane is attached http://purl.obolibrary.org/obo/MP_0003139 patent ductus arteriosus http://purl.obolibrary.org/obo/MP_0010564 abnormal fetal ductus arteriosus morphology failure of the fetal connection between the aorta and pulmonary artery to close after birth http://purl.obolibrary.org/obo/MP_0003140 dilated heart atrium http://purl.obolibrary.org/obo/MP_0004937 dilated heart the luminal space of one or both of the upper chambers of the heart is increased in volume or area, usually with an increase of contained fluid http://purl.obolibrary.org/obo/MP_0003141 cardiac fibrosis http://purl.obolibrary.org/obo/MP_0000266 abnormal heart morphology formation of fibrous tissue within the heart often resulting from inflammation or injury http://purl.obolibrary.org/obo/MP_0003142 anotia http://purl.obolibrary.org/obo/MP_0005579 absent outer ear congenital absence of one or both auricles of the ears http://purl.obolibrary.org/obo/MP_0003143 enlarged otoliths http://purl.obolibrary.org/obo/MP_0002894 abnormal otolith morphology increased average size of the crystalline calciferous particles adhering to the otolithic membrane http://purl.obolibrary.org/obo/MP_0003144 decreased otolith number http://purl.obolibrary.org/obo/MP_0002894 abnormal otolith morphology reduced average number of the crystalline calciferous particles adhering to the otolithic membrane http://purl.obolibrary.org/obo/MP_0003145 detached otolithic membrane http://purl.obolibrary.org/obo/MP_0002895 abnormal otolithic membrane morphology the otolithic (otoconial) membrane is abnormally detached from the underlying neuroepithelium http://purl.obolibrary.org/obo/MP_0003146 absent cochlear ganglion http://purl.obolibrary.org/obo/MP_0002855 abnormal cochlear ganglion morphology absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve) http://purl.obolibrary.org/obo/MP_0003147 absent cochlea http://purl.obolibrary.org/obo/MP_0000031 abnormal cochlea morphology absence or agenesis of the spiral-shaped bony canal in the inner ear containing the hair cells that transduce sound http://purl.obolibrary.org/obo/MP_0003148 decreased cochlear coiling http://purl.obolibrary.org/obo/MP_0000031 abnormal cochlea morphology a reduction in cochlear coiling or number of turns; in wild-type mice, the cochlea most commonly exhibits one and three-fourth turns http://purl.obolibrary.org/obo/MP_0003149 abnormal tectorial membrane morphology http://purl.obolibrary.org/obo/MP_0003169 abnormal scala media morphology any structural anomaly of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells; sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair cell membrane potential, transducing sound into electrical signals http://purl.obolibrary.org/obo/MP_0003150 detached tectorial membrane http://purl.obolibrary.org/obo/MP_0003149 abnormal tectorial membrane morphology tectorial membrane is abnormally detached from the cochlear epithelium or spiral limbus http://purl.obolibrary.org/obo/MP_0003151 absent tunnel of Corti http://purl.obolibrary.org/obo/MP_0000042 abnormal organ of Corti morphology complete absence of the triangular, fluid-filled space normally found between the inner and outer rows of supporting pillar cells in the organ of Corti http://purl.obolibrary.org/obo/MP_0003152 abnormal pillar cell differentiation http://purl.obolibrary.org/obo/MP_0008304 abnormal organ of Corti supporting cell differentiation abnormal differentiation of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti http://purl.obolibrary.org/obo/MP_0003153 early eyelid opening http://purl.obolibrary.org/obo/MP_0004874 abnormal timing of postnatal eyelid opening early average time for the first postnatal eye opening http://purl.obolibrary.org/obo/MP_0003154 abnormal soft palate morphology http://purl.obolibrary.org/obo/MP_0003755 abnormal palate morphology any structural anomaly of the musculomembranous fold that partly separates the mouth and pharynx, located behind the hard palate in the adult http://purl.obolibrary.org/obo/MP_0003155 abnormal telomere length http://purl.obolibrary.org/obo/MP_0010207 abnormal telomere morphology abnormal length of the terminal repetitive DNA section of a chromosome which is involved in chromosomal replication and senescence, and which protects the end of the chromosome from deterioration; normal length is a few hundred base pairs http://purl.obolibrary.org/obo/MP_0003156 abnormal leukocyte migration http://purl.obolibrary.org/obo/MP_0003091 abnormal cell migration altered ability of blood leukocytes to move within or between different tissues and organs of the body by binding to high endothelial venules (HEV), then tethering and rolling along the luminal aspects of HEV http://purl.obolibrary.org/obo/MP_0003157 impaired muscle relaxation http://purl.obolibrary.org/obo/MP_0004036 abnormal muscle relaxation reduced or absent ability of muscle to lengthen following contractions http://purl.obolibrary.org/obo/MP_0003158 dysphagia http://purl.obolibrary.org/obo/MP_0005449 abnormal food intake difficulty in swallowing food or liquid http://purl.obolibrary.org/obo/MP_0003159 abnormal esophageal smooth muscle morphology http://purl.obolibrary.org/obo/MP_0000767 abnormal smooth muscle morphology any structural anomaly of the nonstriated, involuntary muscle tissue lining the esophagus http://purl.obolibrary.org/obo/MP_0003160 abnormal esophagus development http://purl.obolibrary.org/obo/MP_0003119 abnormal digestive system development aberrant formation of the part of the digestive canal through which food passes from the pharynx to the stomach http://purl.obolibrary.org/obo/MP_0003161 absent lateral semicircular canal http://purl.obolibrary.org/obo/MP_0000037 abnormal lateral semicircular canal morphology absence of the lateral long bony tube of the labyrinth that is involved in the sense of balance http://purl.obolibrary.org/obo/MP_0003162 decreased lateral semicircular canal size http://purl.obolibrary.org/obo/MP_0000037 abnormal lateral semicircular canal morphology small size of the lateral long bony tube of the labyrinth that is involved in the sense of balance http://purl.obolibrary.org/obo/MP_0003163 absent posterior semicircular canal http://purl.obolibrary.org/obo/MP_0002858 abnormal posterior semicircular canal morphology absence of the posterior segment of the long bony tube of the labyrinth that is involved in the sense of balance http://purl.obolibrary.org/obo/MP_0003164 decreased posterior semicircular canal size http://purl.obolibrary.org/obo/MP_0002858 abnormal posterior semicircular canal morphology small size of the posterior segment of the long bony tube of the labyrinth that is involved in the sense of balance http://purl.obolibrary.org/obo/MP_0003165 absent superior semicircular canal http://purl.obolibrary.org/obo/MP_0003069 abnormal superior semicircular canal morphology absence of the upper, superior segment of the long bony tube of the labyrinth that is involved in the sense of balance http://purl.obolibrary.org/obo/MP_0003166 decreased superior semicircular canal size http://purl.obolibrary.org/obo/MP_0003069 abnormal superior semicircular canal morphology small size of the upper, superior segment of the long bony tube of the labyrinth that is involved in the sense of balance http://purl.obolibrary.org/obo/MP_0003167 abnormal scala tympani morphology http://purl.obolibrary.org/obo/MP_0000031 abnormal cochlea morphology any structural anomaly of the division of the spiral canal of the cochlea lying on the basal side of the spiral lamina http://purl.obolibrary.org/obo/MP_0003168 abnormal scala vestibuli morphology http://purl.obolibrary.org/obo/MP_0000031 abnormal cochlea morphology any structural anomaly of the division of the spiral canal of the cochlea lying on the apical side of the spiral lamina and vestibular membrane http://purl.obolibrary.org/obo/MP_0003169 abnormal scala media morphology http://purl.obolibrary.org/obo/MP_0004426 abnormal cochlear labyrinth morphology any structural anomaly of the division of the spiral canal of the cochlea that contains the organ of Corti (the neuroepithelial receptor organ for hearing) http://purl.obolibrary.org/obo/MP_0003171 phenotypic reversion http://purl.obolibrary.org/obo/MP_0002873 normal phenotype wild-type phenotype restored from a previously characterized mutant phenotype http://purl.obolibrary.org/obo/MP_0003172 abnormal lysosome physiology http://purl.obolibrary.org/obo/MP_0005621 abnormal cell physiology ability of lysosomes to produce enzymes necessary for digestion of exogenous material is impaired http://purl.obolibrary.org/obo/MP_0003173 decreased lysosomal enzyme secretion http://purl.obolibrary.org/obo/MP_0003172 abnormal lysosome physiology production or release of glycoprotein hydrolytic enzymes is decreased compared to normal http://purl.obolibrary.org/obo/MP_0003174 increased lysosomal enzyme secretion http://purl.obolibrary.org/obo/MP_0003172 abnormal lysosome physiology production or secretion of glycoprotein hydrolytic enzymes is increased compared to normal http://purl.obolibrary.org/obo/MP_0003175 reversion by mitotic recombination http://purl.obolibrary.org/obo/MP_0003171 phenotypic reversion cross-over event between sequences containing mutant and wild-type alleles during DNA replication in a heterozygote resulting in cells with two wild-type alleles http://purl.obolibrary.org/obo/MP_0003176 reversion by viral sequence excision http://purl.obolibrary.org/obo/MP_0003171 phenotypic reversion restoration of wild-type phenotype by removal of a viral sequence or a viral- related sequence that produced a mutant phenotype http://purl.obolibrary.org/obo/MP_0003177 allodynia http://purl.obolibrary.org/obo/MP_0001970 abnormal pain threshold condition in which nonpainful stimuli evoke a pain sensation http://purl.obolibrary.org/obo/MP_0003178 left pulmonary isomerism http://purl.obolibrary.org/obo/MP_0010853 abnormal lung position or orientation anomaly in the asymmetry of the lung such that the lobes on both the left and right side have the morphology normally seen on the left side of the body http://purl.obolibrary.org/obo/MP_0003179 decreased platelet cell number http://purl.obolibrary.org/obo/MP_0011898 abnormal platelet cell number fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation http://purl.obolibrary.org/obo/MP_0003180 abnormal pulmonary endothelial cell surface http://purl.obolibrary.org/obo/MP_0006055 abnormal vascular endothelial cell morphology altered morphology or area of the semipermeable membrane that encloses the cytoplasm of a pulmonary endothelial cell http://purl.obolibrary.org/obo/MP_0003181 increased pulmonary endothelial cell surface http://purl.obolibrary.org/obo/MP_0003180 abnormal pulmonary endothelial cell surface increased total area of the semipermeable membrane that encloses the cytoplasm of a pulmonary endothelial cell http://purl.obolibrary.org/obo/MP_0003182 decreased pulmonary endothelial cell surface http://purl.obolibrary.org/obo/MP_0003180 abnormal pulmonary endothelial cell surface reduced total area of the semipermeable membrane that encloses the cytoplasm of a pulmonary endothelial cell http://purl.obolibrary.org/obo/MP_0003184 increased angiotensin I-converting enzyme activity http://purl.obolibrary.org/obo/MP_0013254 abnormal angiotensin I-converting enzyme activity greater activity of the exopeptidase that catalyses the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, and is also involved in the inactivation of bradykinin http://purl.obolibrary.org/obo/MP_0003185 decreased angiotensin I-converting enzyme activity http://purl.obolibrary.org/obo/MP_0013254 abnormal angiotensin I-converting enzyme activity reduced activity of the exopeptidase that catalyses the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, and is also involved in the inactivation of bradykinin http://purl.obolibrary.org/obo/MP_0003186 abnormal redox activity http://purl.obolibrary.org/obo/MP_0005621 abnormal cell physiology defect in the processes that maintain the redox environment of a cell or compartment within a cell http://purl.obolibrary.org/obo/MP_0003189 fused joints http://purl.obolibrary.org/obo/MP_0002932 abnormal joint morphology partial or complete absence of a functional articulation point of two or more bones http://purl.obolibrary.org/obo/MP_0003190 fused synovial joints http://purl.obolibrary.org/obo/MP_0003189 fused joints partial or complete absence of separations containing synovial fluid between bones http://purl.obolibrary.org/obo/MP_0003191 abnormal cellular cholesterol metabolism http://purl.obolibrary.org/obo/MP_0013245 abnormal lipid metabolism impaired regulation of cellular cholesterol levels http://purl.obolibrary.org/obo/MP_0003192 increased cholesterol efflux http://purl.obolibrary.org/obo/MP_0003191 abnormal cellular cholesterol metabolism greater level of removal of excess cholesterol from cells by an active transport pathway http://purl.obolibrary.org/obo/MP_0003193 decreased cholesterol efflux http://purl.obolibrary.org/obo/MP_0003191 abnormal cellular cholesterol metabolism reduced level of removal of excess cholesterol from cells by an active transport pathway http://purl.obolibrary.org/obo/MP_0003194 abnormal frequency of paradoxical sleep http://purl.obolibrary.org/obo/MP_0012288 abnormal paradoxical sleep pattern abnormal incidence or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity http://purl.obolibrary.org/obo/MP_0003195 calcinosis http://purl.obolibrary.org/obo/MP_0004231 abnormal calcium ion homeostasis pathologic deposition of calcium salts in tissues http://purl.obolibrary.org/obo/MP_0003196 calcified skin http://purl.obolibrary.org/obo/MP_0002060 abnormal skin morphology pathologic deposition of calcium salts in the skin http://purl.obolibrary.org/obo/MP_0003197 nephrocalcinosis http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology diffusely scattered foci of calcification in the renal parenchyma, with microscopic or macroscopic deposits of calcium salts http://purl.obolibrary.org/obo/MP_0003198 calcified tendon http://purl.obolibrary.org/obo/MP_0005503 abnormal tendon morphology pathologic deposition of calcium salts in the tendons http://purl.obolibrary.org/obo/MP_0003199 calcified muscle http://purl.obolibrary.org/obo/MP_0002108 abnormal muscle morphology pathologic deposition of calcium salts in muscle http://purl.obolibrary.org/obo/MP_0003200 calcified joint http://purl.obolibrary.org/obo/MP_0002932 abnormal joint morphology pathologic deposition of calcium salts in the joints http://purl.obolibrary.org/obo/MP_0003201 extremity edema http://purl.obolibrary.org/obo/MP_0001785 edema an accumulation of serous fluid in the limbs, paws and tail http://purl.obolibrary.org/obo/MP_0003202 abnormal neuron apoptosis http://purl.obolibrary.org/obo/MP_0004811 abnormal neuron physiology change in the timing or the number of neurons undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0003203 increased neuron apoptosis http://purl.obolibrary.org/obo/MP_0006042 increased apoptosis increase in the number of neurons undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0003204 decreased neuron apoptosis http://purl.obolibrary.org/obo/MP_0006043 decreased apoptosis decrease in the number of neurons undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0003205 testicular atrophy http://purl.obolibrary.org/obo/MP_0001147 small testis acquired diminution of the size of the testis associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0003207 decreased cellular sensitivity to gamma-irradiation http://purl.obolibrary.org/obo/MP_0004228 decreased cellular sensitivity to ionizing radiation decreased incidence of cell death following exposure to gamma-irradiation http://purl.obolibrary.org/obo/MP_0003208 abnormal neuromere morphology http://purl.obolibrary.org/obo/MP_0002151 abnormal neural tube morphology/development any structural anomaly of the segments of the developing neural tube http://purl.obolibrary.org/obo/MP_0003209 abnormal pulmonary elastic fiber morphology http://purl.obolibrary.org/obo/MP_0001175 abnormal lung morphology any structural anomaly of a slender connective tissue fiber in pulmonary tissue characterized by great elasticity http://purl.obolibrary.org/obo/MP_0003210 abnormal heart elastic fiber morphology http://purl.obolibrary.org/obo/MP_0009863 abnormal heart elastic tissue morphology any structural anomaly of the slender connective tissue fiber in cardiac tissue characterized by great elasticity http://purl.obolibrary.org/obo/MP_0003211 abnormal aorta elastic fiber morphology http://purl.obolibrary.org/obo/MP_0009862 abnormal aorta elastic tissue morphology any structural anomaly of the slender connective tissue fiber in aortic tissue characterized by great elasticity http://purl.obolibrary.org/obo/MP_0003212 increased susceptibility to age related obesity http://purl.obolibrary.org/obo/MP_0005455 increased susceptibility to weight gain increased probability of excessive weight gain that is progressive with age http://purl.obolibrary.org/obo/MP_0003213 decreased susceptibility to age related obesity http://purl.obolibrary.org/obo/MP_0010182 decreased susceptibility to weight gain reduced probability of excessive weight gain that is progressive with age http://purl.obolibrary.org/obo/MP_0003214 neurofibrillary tangles http://purl.obolibrary.org/obo/MP_0002152 abnormal brain morphology dense intraneuronal accumulations of helical filaments (neurofilaments and microtubules) that assume twisted contorted patterns; found in subclasses of cells of the neocortex, hippocampus, brain stem, and diencephalon in individuals with Alzheimer disease and other tauopathies http://purl.obolibrary.org/obo/MP_0003215 renal interstitial fibrosis http://purl.obolibrary.org/obo/MP_0011425 abnormal kidney interstitium morphology formation of fibrous tissue within the functional space in the kidney beneath the individual filters (glomeruli) as a result of repair or a reactive process http://purl.obolibrary.org/obo/MP_0003216 absence seizures http://purl.obolibrary.org/obo/MP_0000948 nonconvulsive seizures impairment of consciousness without convulsions associated with sudden behavioral arrest and widespread bilaterally synchronous spike-and-wave discharges (SWDs) in the electroencephalogram (EEG) http://purl.obolibrary.org/obo/MP_0003217 increased spike-wave discharge type I http://purl.obolibrary.org/obo/MP_0008840 abnormal spike wave discharge increase in one type of epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy, characterized by immediate, bilaterally symmetric discharges, generalized over the cortex and lasting longer than spike-wave discharge type II http://purl.obolibrary.org/obo/MP_0003218 decreased spike-wave discharge type I http://purl.obolibrary.org/obo/MP_0008840 abnormal spike wave discharge decrease in one type of epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy, characterized by immediate, bilaterally symmetric discharges, generalized over the cortex and lasting longer than Spike-wave discharge type II http://purl.obolibrary.org/obo/MP_0003219 increased spike-wave discharge type II http://purl.obolibrary.org/obo/MP_0008840 abnormal spike wave discharge increase in one type of epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy, characterized by local occipital-parietal discharges that are shorter and have less clear waves than spike-wave discharge type I http://purl.obolibrary.org/obo/MP_0003220 decreased spike-wave discharge type II http://purl.obolibrary.org/obo/MP_0008840 abnormal spike wave discharge decrease in one type of epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy, characterized by local occipital-parietal discharges that are shorter and have less clear waves than spike-wave discharge type I http://purl.obolibrary.org/obo/MP_0003221 abnormal cardiomyocyte apoptosis http://purl.obolibrary.org/obo/MP_0004215 abnormal myocardial fiber physiology change in the timing or the number of cardiac muscle cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0003222 increased cardiomyocyte apoptosis http://purl.obolibrary.org/obo/MP_0006042 increased apoptosis increase in the number of cardiac muscle cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0003223 decreased cardiomyocyte apoptosis http://purl.obolibrary.org/obo/MP_0006043 decreased apoptosis decrease in the number of cardiac muscle cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0003224 neuron degeneration http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses http://purl.obolibrary.org/obo/MP_0003225 axonal dystrophy http://purl.obolibrary.org/obo/MP_0005405 axon degeneration axon degeneration that may result from genetic abnormalities or inadequate or faulty metabolism http://purl.obolibrary.org/obo/MP_0003226 absent modiolus http://purl.obolibrary.org/obo/MP_0003309 abnormal modiolus morphology absence of the central cone shaped core of spongy bone about which turns the spiral canal http://purl.obolibrary.org/obo/MP_0003227 abnormal vascular branching morphogenesis http://purl.obolibrary.org/obo/MP_0000260 abnormal angiogenesis increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels http://purl.obolibrary.org/obo/MP_0003228 abnormal sinus venosus morphology http://purl.obolibrary.org/obo/MP_0000267 abnormal heart development any structural anomaly of the cavity at the caudal end of the embryonic cardiac tube in which the veins from the intra- and extraembryonic circulatory arcs unite; in the adult this becomes the portion of the right atrium known as the sinus of the vena cava http://purl.obolibrary.org/obo/MP_0003229 abnormal vitelline vasculature morphology http://purl.obolibrary.org/obo/MP_0002086 abnormal extraembryonic tissue morphology any structural anomaly of the vascular network that supplies the yolk sac http://purl.obolibrary.org/obo/MP_0003230 abnormal umbilical artery morphology http://purl.obolibrary.org/obo/MP_0012300 abnormal umbilical cord blood vessel morphology any structural anomaly of the paired arteries that bring unoxygenated blood back to the placenta from the dorsal aorta through the umbilical cord http://purl.obolibrary.org/obo/MP_0003231 abnormal placenta vasculature http://purl.obolibrary.org/obo/MP_0001711 abnormal placenta morphology any structural anomaly of the vessels of the placenta http://purl.obolibrary.org/obo/MP_0003232 abnormal forebrain development http://purl.obolibrary.org/obo/MP_0000913 abnormal brain development anomaly in the formation or patterning of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions) http://purl.obolibrary.org/obo/MP_0003233 prolonged QT interval http://purl.obolibrary.org/obo/MP_0003899 abnormal QT interval increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time, and is measured from the beginning of the QRS complex to the end of the T wave http://purl.obolibrary.org/obo/MP_0003234 enhanced NMDA-mediated synaptic currents http://purl.obolibrary.org/obo/MP_0002888 abnormal NMDA-mediated synaptic currents increase in the measured amplitude, current density or duration of response to stimulation of NMDA receptors http://purl.obolibrary.org/obo/MP_0003235 abnormal alisphenoid bone morphology http://purl.obolibrary.org/obo/MP_0000104 abnormal sphenoid bone morphology any structural anomaly of either of the broad curved wing like expanses on each side of the sphenoid bone in adults; may exist independently in the young http://purl.obolibrary.org/obo/MP_0003236 abnormal lens capsule morphology http://purl.obolibrary.org/obo/MP_0001303 abnormal lens morphology any structural anomaly of the elastic, clear, membrane-like structure, that is outer most layer of the lens http://purl.obolibrary.org/obo/MP_0003237 abnormal lens epithelium morphology http://purl.obolibrary.org/obo/MP_0001303 abnormal lens morphology any structural anomaly in the one or more of the layers of epithelial cells in the lens http://purl.obolibrary.org/obo/MP_0003238 slow REM http://purl.obolibrary.org/obo/MP_0012288 abnormal paradoxical sleep pattern decreased rapid, periodic, jerky movement of the eyes from average during certain stages of the sleep cycle when dreaming takes place http://purl.obolibrary.org/obo/MP_0003239 fast REM http://purl.obolibrary.org/obo/MP_0012288 abnormal paradoxical sleep pattern increased rapid, periodic, jerky movement of the eyes from average during certain stages of the sleep cycle when dreaming takes place http://purl.obolibrary.org/obo/MP_0003240 loss of hippocampal neurons http://purl.obolibrary.org/obo/MP_0009939 abnormal hippocampus neuron morphology loss of neurons in the hippocampal region of the brain, commonly due to an apoptotic event http://purl.obolibrary.org/obo/MP_0003241 loss of cortex neurons http://purl.obolibrary.org/obo/MP_0000788 abnormal cerebral cortex morphology loss of neurons in the cortex region of the brain, commonly due to an apoptotic event http://purl.obolibrary.org/obo/MP_0003242 loss of basal ganglia neurons http://purl.obolibrary.org/obo/MP_0006007 abnormal basal ganglion morphology loss of neurons in the basal ganglia of the brain, commonly due to an apoptotic event http://purl.obolibrary.org/obo/MP_0003243 abnormal dopaminergic neuron morphology http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology any structural anomaly of the neurons that utilize dopamine as a neurotransmitter http://purl.obolibrary.org/obo/MP_0003244 loss of dopaminergic neurons http://purl.obolibrary.org/obo/MP_0003243 abnormal dopaminergic neuron morphology loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event http://purl.obolibrary.org/obo/MP_0003245 abnormal GABAergic neuron morphology http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology any structural anomaly of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter http://purl.obolibrary.org/obo/MP_0003246 loss of GABAergic neurons http://purl.obolibrary.org/obo/MP_0003245 abnormal GABAergic neuron morphology loss of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter, commonly due to an apoptotic event http://purl.obolibrary.org/obo/MP_0003247 abnormal glutaminergic neuron morphology http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology any structural anomaly of the neurons that utilize glutamate as a neurotransmitter http://purl.obolibrary.org/obo/MP_0003248 loss of glutamate neurons http://purl.obolibrary.org/obo/MP_0003247 abnormal glutaminergic neuron morphology loss of the neurons that utilize glutamate as a neurotransmitter, commonly due to an apoptotic event http://purl.obolibrary.org/obo/MP_0003249 increased muscle free fatty acid level http://purl.obolibrary.org/obo/MP_0010358 abnormal free fatty acids level greater than normal muscle concentration of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacylglycerols are taken into tissues http://purl.obolibrary.org/obo/MP_0003250 absent gallbladder http://purl.obolibrary.org/obo/MP_0005084 abnormal gallbladder morphology absence of the organ which serves as a storage reservoir for bile http://purl.obolibrary.org/obo/MP_0003251 gallbladder inflammation http://purl.obolibrary.org/obo/MP_0005085 abnormal gallbladder physiology local accumulation of fluid, plasma proteins, and leukocytes in the gall bladder http://purl.obolibrary.org/obo/MP_0003252 abnormal bile duct physiology http://purl.obolibrary.org/obo/MP_0002139 abnormal hepatobiliary system physiology any functional anomaly of the channels that secrete bile from the liver to the gall bladder and intestines http://purl.obolibrary.org/obo/MP_0003253 dilated bile duct http://purl.obolibrary.org/obo/MP_0002928 abnormal bile duct morphology the luminal space of the bile ducts is increased in volume or area, usually with an increase in contained fluid or bile http://purl.obolibrary.org/obo/MP_0003254 bile duct inflammation http://purl.obolibrary.org/obo/MP_0003252 abnormal bile duct physiology local accumulation of fluid, plasma proteins, and leukocytes in the bile ducts http://purl.obolibrary.org/obo/MP_0003255 bile duct proliferation http://purl.obolibrary.org/obo/MP_0003252 abnormal bile duct physiology the appearance of an increased number of bile ducts in the liver; a sign of progressive liver disease http://purl.obolibrary.org/obo/MP_0003256 biliary cirrhosis http://purl.obolibrary.org/obo/MP_0003252 abnormal bile duct physiology liver damage to parenchymal cells due to obstruction of bile flow in the bile ducts http://purl.obolibrary.org/obo/MP_0003257 abnormal abdominal wall morphology http://purl.obolibrary.org/obo/MP_0003385 abnormal body wall morphology any structural anomaly of the margins that enclose the abdominal cavity; the major part is muscular but also includes skin, subcutaneous fat, fascia and the parietal peritoneum http://purl.obolibrary.org/obo/MP_0003258 hiatal hernia http://purl.obolibrary.org/obo/MP_0003257 abnormal abdominal wall morphology protrusion of abdominal structures through the esophageal hiatus of the diaphragm http://purl.obolibrary.org/obo/MP_0003259 nausea http://purl.obolibrary.org/obo/MP_0001664 abnormal digestion gastric discomfort associated with the inclination to vomit http://purl.obolibrary.org/obo/MP_0003260 vomiting http://purl.obolibrary.org/obo/MP_0001664 abnormal digestion the retrograde expulsion of gastric contents through the oral cavity http://purl.obolibrary.org/obo/MP_0003261 hematemesis http://purl.obolibrary.org/obo/MP_0003260 vomiting vomiting of blood; indicative of bleeding in the upper gastrointestinal tract http://purl.obolibrary.org/obo/MP_0003262 intestinal/bowel diverticulum http://purl.obolibrary.org/obo/MP_0000477 abnormal intestine morphology a pouch or sac protruding from the intestinal or bowel wall http://purl.obolibrary.org/obo/MP_0003266 biliary cyst http://purl.obolibrary.org/obo/MP_0002928 abnormal bile duct morphology the appearance of fluid-filled sacs within the bile ducts http://purl.obolibrary.org/obo/MP_0003267 constipation http://purl.obolibrary.org/obo/MP_0003866 abnormal defecation incomplete, infrequent or difficult evacuation of fecal matter http://purl.obolibrary.org/obo/MP_0003268 chronic constipation http://purl.obolibrary.org/obo/MP_0003267 constipation prolonged or long-term difficulty in evacuation of fecal matter http://purl.obolibrary.org/obo/MP_0003269 colon polyps http://purl.obolibrary.org/obo/MP_0008011 intestine polyps abnormal tissue masses that protrude into the lumen of the colon and are tethered to the wall of the colon http://purl.obolibrary.org/obo/MP_0003270 intestinal obstruction http://purl.obolibrary.org/obo/MP_0011082 abnormal gastrointestinal motility any impediment, blockage, or reversal of the normal flow of the intestinal contents toward the anus http://purl.obolibrary.org/obo/MP_0003271 abnormal duodenum morphology http://purl.obolibrary.org/obo/MP_0000496 abnormal small intestine morphology any structural anomaly of the first division of the small intestine that extends from the pyloris to the junction with the jejunum http://purl.obolibrary.org/obo/MP_0003272 duodenal atresia http://purl.obolibrary.org/obo/MP_0003271 abnormal duodenum morphology congenital blockage or absence of the lumen of the duodenum http://purl.obolibrary.org/obo/MP_0003273 duodenal ulcer http://purl.obolibrary.org/obo/MP_0003301 peptic ulcer a lesion on the mucosal surface of the duodenum, usually produced by the sloughing of inflammatory necrotic tissue http://purl.obolibrary.org/obo/MP_0003274 intestinal microaneurysm http://purl.obolibrary.org/obo/MP_0003279 aneurysm focal dilation of arteriocapillary junctions in the intestine http://purl.obolibrary.org/obo/MP_0003275 gastric microaneurysm http://purl.obolibrary.org/obo/MP_0003279 aneurysm focal dilation of arteriocapillary junctions in the stomach http://purl.obolibrary.org/obo/MP_0003276 esophageal atresia http://purl.obolibrary.org/obo/MP_0000467 abnormal esophagus morphology congenital blockage or absence of the lumen of the esophagus http://purl.obolibrary.org/obo/MP_0003277 increased esophageal papilloma incidence http://purl.obolibrary.org/obo/MP_0010292 increased alimentary system tumor incidence higher than normal incidence of a benign epithelial tumor consisting of villous or arborescent outgrowths of fibrovascular stroma of the esophagus http://purl.obolibrary.org/obo/MP_0003278 esophageal inflammation http://purl.obolibrary.org/obo/MP_0001846 increased inflammatory response local accumulation of fluid, plasma proteins and leukocytes in the esophagus http://purl.obolibrary.org/obo/MP_0003279 aneurysm http://purl.obolibrary.org/obo/MP_0002127 abnormal cardiovascular system morphology a protruding sac formed by the dilation of the wall of an artery, a vein, or the heart resulting from a weakening of the vessel wall or heart muscle http://purl.obolibrary.org/obo/MP_0003280 urinary incontinence http://purl.obolibrary.org/obo/MP_0001756 abnormal urination inability to control the urinary excretory functions http://purl.obolibrary.org/obo/MP_0003281 fecal incontinence http://purl.obolibrary.org/obo/MP_0003866 abnormal defecation inability to control the anal sphincter resulting in the involuntary passage of feces http://purl.obolibrary.org/obo/MP_0003282 gastric ulcer http://purl.obolibrary.org/obo/MP_0010792 abnormal stomach mucosa morphology a lesion on the mucosal surface of the stomach, usually produced by the sloughing of inflammatory necrotic tissue http://purl.obolibrary.org/obo/MP_0003283 abnormal digestive organ placement http://purl.obolibrary.org/obo/MP_0000462 abnormal digestive system morphology different location or arrangement of any of the alimentary tract organs http://purl.obolibrary.org/obo/MP_0003284 abnormal large intestine placement http://purl.obolibrary.org/obo/MP_0003283 abnormal digestive organ placement different location or arrangement of the large intestinal tract http://purl.obolibrary.org/obo/MP_0003285 gastric hypertrophy http://purl.obolibrary.org/obo/MP_0003883 enlarged stomach increase in the bulk size of the stomach due to cell enlargement or accumulation of fluids http://purl.obolibrary.org/obo/MP_0003286 gastroesophageal reflux http://purl.obolibrary.org/obo/MP_0010154 abnormal gastroesophageal sphincter physiology retrograde movement of gastric contents into the esophagus http://purl.obolibrary.org/obo/MP_0003287 increased intestinal hemangioma incidence http://purl.obolibrary.org/obo/MP_0010279 increased gastrointestinal tumor incidence greater than the expected number of a benign tumor characterized by blood-filled spaces lined by benign endothelial cells in the intestines, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0003288 intestinal edema http://purl.obolibrary.org/obo/MP_0010155 abnormal intestine physiology an accumulation of an excessive amount of serous fluid in the intestine or intestinal cells http://purl.obolibrary.org/obo/MP_0003289 abnormal intestinal peristalsis http://purl.obolibrary.org/obo/MP_0011082 abnormal gastrointestinal motility altered intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward http://purl.obolibrary.org/obo/MP_0003290 intestinal hypoperistalsis http://purl.obolibrary.org/obo/MP_0003289 abnormal intestinal peristalsis reduced intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward http://purl.obolibrary.org/obo/MP_0003291 interstinal hyperperistalsis http://purl.obolibrary.org/obo/MP_0003289 abnormal intestinal peristalsis increased intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward http://purl.obolibrary.org/obo/MP_0003292 melena http://purl.obolibrary.org/obo/MP_0003868 abnormal feces composition dark colored, foul-smelling feces due to the presence of blood http://purl.obolibrary.org/obo/MP_0003293 rectal hemorrhage http://purl.obolibrary.org/obo/MP_0000465 gastrointestinal hemorrhage bleeding in the rectum http://purl.obolibrary.org/obo/MP_0003294 intussusception http://purl.obolibrary.org/obo/MP_0000477 abnormal intestine morphology telescoping of the intestine, or the prolapse of one part of the bowel to another; usually results in obstruction http://purl.obolibrary.org/obo/MP_0003295 lymphomesenteric cysts http://purl.obolibrary.org/obo/MP_0000462 abnormal digestive system morphology cystic mass in the abdominal mesenchyme containing lymph; sometimes becomes calcified http://purl.obolibrary.org/obo/MP_0003296 microcolon http://purl.obolibrary.org/obo/MP_0000495 abnormal colon morphology small, unused colon in neonates, usually due to atresia or other gastrointestinal blockage http://purl.obolibrary.org/obo/MP_0003298 choking http://purl.obolibrary.org/obo/MP_0002133 abnormal respiratory system physiology spasm of the larynx and trachea due to prevention of respiration by compression or obstruction http://purl.obolibrary.org/obo/MP_0003299 gastric polyps http://purl.obolibrary.org/obo/MP_0010352 gastrointestinal tract polyps abnormal tissue masses that protrude into the lumen of the stomach and are tethered to the wall of the stomach http://purl.obolibrary.org/obo/MP_0003300 gastrointestinal ulcer http://purl.obolibrary.org/obo/MP_0000462 abnormal digestive system morphology any lesion on the mucosal surface of the gastrointestinal tract, usually produced by the sloughing of inflammatory necrotic tissue http://purl.obolibrary.org/obo/MP_0003301 peptic ulcer http://purl.obolibrary.org/obo/MP_0003300 gastrointestinal ulcer any lesion on the mucosal surface of the portion of the alimentary tract that is exposed to gastric acid, usually in the stomach or the duodenum http://purl.obolibrary.org/obo/MP_0003302 perirectal abscess http://purl.obolibrary.org/obo/MP_0000492 abnormal rectum morphology acute focal inflammation of the tissues surrounding the rectum, often with accumulation of purulent material http://purl.obolibrary.org/obo/MP_0003303 peritoneal inflammation http://purl.obolibrary.org/obo/MP_0001846 increased inflammatory response local accumulation of fluid, plasma proteins, and leukocytes in the membrane that lines the abdominal cavity and covers most of the viscera http://purl.obolibrary.org/obo/MP_0003304 large intestinal inflammation http://purl.obolibrary.org/obo/MP_0001858 intestinal inflammation local accumulation of fluid, plasma proteins, and leukocytes in the large intestine http://purl.obolibrary.org/obo/MP_0003305 proctitis http://purl.obolibrary.org/obo/MP_0003304 large intestinal inflammation local accumulation of fluid, plasma proteins, and leukocytes in the mucous membrane of the rectum http://purl.obolibrary.org/obo/MP_0003306 small intestinal inflammation http://purl.obolibrary.org/obo/MP_0001858 intestinal inflammation local accumulation of fluid, plasma proteins, and leukocytes in the small intestine http://purl.obolibrary.org/obo/MP_0003307 pyloric stenosis http://purl.obolibrary.org/obo/MP_0010785 abnormal stomach pyloric region morphology a narrowing of the gastric outlet of the stomach, often due to muscular hypertrophy or scarring from local inflammation http://purl.obolibrary.org/obo/MP_0003308 abnormal cochlear sensory epithelium morphology http://purl.obolibrary.org/obo/MP_0000031 abnormal cochlea morphology any structural anomaly of the epithelial cell layer containing the sensory hair cells and their associated sensory nerve terminals http://purl.obolibrary.org/obo/MP_0003309 abnormal modiolus morphology http://purl.obolibrary.org/obo/MP_0000031 abnormal cochlea morphology any structural anomaly of the central cone shaped core of spongy bone about which turns the spiral canal http://purl.obolibrary.org/obo/MP_0003310 reduced modiolus http://purl.obolibrary.org/obo/MP_0003309 abnormal modiolus morphology a reduction in the volume of the central conical bony pillar of the cochlea http://purl.obolibrary.org/obo/MP_0003311 aminoaciduria http://purl.obolibrary.org/obo/MP_0011468 abnormal urine amino acid level excretion of amino acids in the urine, especially in excessive amounts http://purl.obolibrary.org/obo/MP_0003312 abnormal locomotor coordination http://purl.obolibrary.org/obo/MP_0001392 abnormal locomotor behavior reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in behavioral locomotor activity http://purl.obolibrary.org/obo/MP_0003313 abnormal locomotor activation http://purl.obolibrary.org/obo/MP_0001392 abnormal locomotor behavior altered ability or desire of an animal to initiate locomotor activity http://purl.obolibrary.org/obo/MP_0003314 dysmetria http://purl.obolibrary.org/obo/MP_0001516 abnormal motor coordination/ balance an inability to control the range of motion, typified by under- or over-shooting the intended position with the hand, arm, leg or eye http://purl.obolibrary.org/obo/MP_0003315 abnormal perineum morphology http://purl.obolibrary.org/obo/MP_0002160 abnormal reproductive system morphology any structural anomaly of the area between the genital organs and the anus that lies beneath the pelvic diaphragm http://purl.obolibrary.org/obo/MP_0003316 perineal fistula http://purl.obolibrary.org/obo/MP_0003315 abnormal perineum morphology an abnormal anatomical passage that connects the perineum to organs such as the bladder or the rectum http://purl.obolibrary.org/obo/MP_0003317 anoperineal fistula http://purl.obolibrary.org/obo/MP_0009053 abnormal anal canal morphology an abnormal anatomical passage that connects the perineum to the anal canal http://purl.obolibrary.org/obo/MP_0003318 rectoperineal fistula http://purl.obolibrary.org/obo/MP_0003316 perineal fistula an abnormal anatomical passage that connects the perineum to the rectum http://purl.obolibrary.org/obo/MP_0003319 anal fistula http://purl.obolibrary.org/obo/MP_0005034 abnormal anus morphology an abnormal anatomical passage at or near the anus that usually opens into the rectum above the internal sphincter http://purl.obolibrary.org/obo/MP_0003320 rectovaginal fistula http://purl.obolibrary.org/obo/MP_0001139 abnormal vagina morphology an abnormal anatomical passage connecting the rectum and the vagina http://purl.obolibrary.org/obo/MP_0003321 tracheoesophageal fistula http://purl.obolibrary.org/obo/MP_0002282 abnormal trachea morphology an abnormal passage is present between the esophagus and the trachea; may be acquired or congenital, and is often associated with esophageal atresia http://purl.obolibrary.org/obo/MP_0003322 biliary fistula http://purl.obolibrary.org/obo/MP_0005083 abnormal biliary tract morphology an abnormal anatomical passage that connects any organ of the biliary tract and other organs http://purl.obolibrary.org/obo/MP_0003323 gastrocolic fistula http://purl.obolibrary.org/obo/MP_0000495 abnormal colon morphology an abnormal anatomical passage between the stomach and the colon http://purl.obolibrary.org/obo/MP_0003324 increased liver adenoma incidence http://purl.obolibrary.org/obo/MP_0010383 increased adenoma incidence greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the liver, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0003325 decreased liver function http://purl.obolibrary.org/obo/MP_0000609 abnormal liver physiology reduced normal function of this bile-secreting exocrine gland, which is important for detoxification, for fat, carbohydrate, and protein metabolism, and for glycogen storage http://purl.obolibrary.org/obo/MP_0003326 liver failure http://purl.obolibrary.org/obo/MP_0000609 abnormal liver physiology cessation of function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage http://purl.obolibrary.org/obo/MP_0003327 liver cysts http://purl.obolibrary.org/obo/MP_0000598 abnormal liver morphology abnormal membranous sacs in any portion of the liver http://purl.obolibrary.org/obo/MP_0003328 portal hypertension http://purl.obolibrary.org/obo/MP_0001544 abnormal cardiovascular system physiology elevation of blood pressure in the hepatic portal vein, often a result of cirrhosis or from obstruction of the portal vein http://purl.obolibrary.org/obo/MP_0003329 amyloid beta deposits http://purl.obolibrary.org/obo/MP_0003632 abnormal nervous system morphology formation of self-assembled aggregates of the cleaved App Abeta protein fragment; often seen in neurodegenerative disorders such as Alzheimer's disease http://purl.obolibrary.org/obo/MP_0003330 abnormal auditory tube http://purl.obolibrary.org/obo/MP_0000049 abnormal middle ear morphology anomaly in the tube connecting the tympanic cavity and the nasopharynx that allows equalization of pressure between the tympanic cavity and the environment http://purl.obolibrary.org/obo/MP_0003331 increased hepatocellular carcinoma incidence http://purl.obolibrary.org/obo/MP_0008019 increased liver tumor incidence greater than the expected number of a malignant neoplasm arising from liver cells, usually in adults and caused by liver trauma due to disease or injury, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0003332 liver abscess http://purl.obolibrary.org/obo/MP_0000598 abnormal liver morphology collection of purulent exudate within the liver as a result of infection by bacteria, protozoa, or other agents http://purl.obolibrary.org/obo/MP_0003333 liver fibrosis http://purl.obolibrary.org/obo/MP_0000598 abnormal liver morphology invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury http://purl.obolibrary.org/obo/MP_0003334 pancreas fibrosis http://purl.obolibrary.org/obo/MP_0001944 abnormal pancreas morphology invasion of fibrous connective tissue into the pancreas, often resulting from inflammation or injury http://purl.obolibrary.org/obo/MP_0003335 exocrine pancreatic insufficiency http://purl.obolibrary.org/obo/MP_0010148 abnormal exocrine pancreas physiology reduced or absent function of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream http://purl.obolibrary.org/obo/MP_0003336 pancreas cysts http://purl.obolibrary.org/obo/MP_0001944 abnormal pancreas morphology the appearance of fluid-filled sacs within the pancreas http://purl.obolibrary.org/obo/MP_0003337 exocrine pancreas hyperplasia http://purl.obolibrary.org/obo/MP_0009110 pancreas hyperplasia overdevelopment or increased size of the portion of the pancreas that secretes digestive enzymes, usually due to an increased cell number http://purl.obolibrary.org/obo/MP_0003338 pancreas lipomatosis http://purl.obolibrary.org/obo/MP_0001944 abnormal pancreas morphology an accumulation of abnormally localized or tumor-like fat in the pancreas http://purl.obolibrary.org/obo/MP_0003339 decreased pancreatic beta cell number http://purl.obolibrary.org/obo/MP_0005217 abnormal pancreatic beta cell morphology fewer than normal number of the cells of the pancreas that secrete insulin http://purl.obolibrary.org/obo/MP_0003340 acute pancreas inflammation http://purl.obolibrary.org/obo/MP_0001869 pancreas inflammation early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into the pancreas; initiated by injury, infection, or local immune response http://purl.obolibrary.org/obo/MP_0003341 chronic pancreas inflammation http://purl.obolibrary.org/obo/MP_0001869 pancreas inflammation persistent inflammatory response in the pancreas, often caused by persistent infection or during an autoimmune response http://purl.obolibrary.org/obo/MP_0003342 accessory spleen http://purl.obolibrary.org/obo/MP_0000689 abnormal spleen morphology the splenic tissue is divided into equal masses; often related to situs inversus http://purl.obolibrary.org/obo/MP_0003344 mammary gland hypoplasia http://purl.obolibrary.org/obo/MP_0000627 abnormal mammary gland morphology underdevelopment or reduced size of the mammary gland, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0003345 decreased rib number http://purl.obolibrary.org/obo/MP_0000150 abnormal rib morphology fewer than normal numbers of the pairs of bony structures that make up the body wall http://purl.obolibrary.org/obo/MP_0003346 abnormal pectoral muscle morphology http://purl.obolibrary.org/obo/MP_0003358 abnormal hypaxial muscle morphology any structural anomaly of the two muscles that make up the upper and fore part of the chest that adduct and rotate the arm and lift the ribs http://purl.obolibrary.org/obo/MP_0003347 hyperpituitarism http://purl.obolibrary.org/obo/MP_0001746 abnormal pituitary secretion hypersecretion of adenohypophyseal hormones from the glandular, anterior portion of the pituitary; often due to a functional adenoma http://purl.obolibrary.org/obo/MP_0003348 hypopituitarism http://purl.obolibrary.org/obo/MP_0001746 abnormal pituitary secretion reduction or cessation of secretion of one or more hormones from the anterior pituitary gland; this may result from ablation, tumors, infarction, or other trauma http://purl.obolibrary.org/obo/MP_0003349 abnormal circulating renin level http://purl.obolibrary.org/obo/MP_0001570 abnormal circulating enzyme level aberrant blood level of the enzyme which is secreted by the kidney and cleaves a bond in angiotensionogen to generate angiotensin I http://purl.obolibrary.org/obo/MP_0003350 increased circulating levels of thyroid hormone http://purl.obolibrary.org/obo/MP_0005468 abnormal thyroid hormone level increased concentration of hormones in the blood that are synthesized and secreted by the thyroid http://purl.obolibrary.org/obo/MP_0003351 decreased circulating levels of thyroid hormone http://purl.obolibrary.org/obo/MP_0005468 abnormal thyroid hormone level reduced concentration of hormones in the blood that are synthesized and secreted by the thyroid http://purl.obolibrary.org/obo/MP_0003352 increased circulating renin level http://purl.obolibrary.org/obo/MP_0003349 abnormal circulating renin level elevated blood level of the enzyme which is secreted by the kidney and cleaves a bond in angiotensionogen to generate angiotensin I http://purl.obolibrary.org/obo/MP_0003353 decreased circulating renin level http://purl.obolibrary.org/obo/MP_0003349 abnormal circulating renin level reduced blood level of the enzyme which is secreted by the kidney and cleaves a bond in angiotensionogen to generate angiotensin I http://purl.obolibrary.org/obo/MP_0003354 astrocytosis http://purl.obolibrary.org/obo/MP_0012065 increased astrocyte number a proliferation or spread of astrocytes into the area of a degenerative lesion or damaged tissue http://purl.obolibrary.org/obo/MP_0003355 decreased ovulation rate http://purl.obolibrary.org/obo/MP_0001928 abnormal ovulation reduction in the frequency in which an ovum (or ova) is/are released from a rupturing ovarian follicle(s) http://purl.obolibrary.org/obo/MP_0003356 impaired luteinization http://purl.obolibrary.org/obo/MP_0003699 abnormal female reproductive system physiology atypical transformation of the mature ovarian follicle and its theca interna into a corpus luteum after ovulation http://purl.obolibrary.org/obo/MP_0003357 impaired granulosa cell differentiation http://purl.obolibrary.org/obo/MP_0008868 abnormal granulosa cell morphology atypical production of or inability to produce the supporting cells for the developing female gamete in the ovary of mammals; granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle http://purl.obolibrary.org/obo/MP_0003358 abnormal hypaxial muscle morphology http://purl.obolibrary.org/obo/MP_0000759 abnormal skeletal muscle morphology any structural anomaly of the muscles derived from the lateral myotome and lateral portion of the dermomyotome; these include the thoracic intercostal and abdominal muscles, limb muscles and superficial back muscles, as well as the diaphragm and the tip of the tongue http://purl.obolibrary.org/obo/MP_0003359 hypaxial muscle hypoplasia http://purl.obolibrary.org/obo/MP_0003358 abnormal hypaxial muscle morphology underdevelopment or reduced size, usually due to a reduced number of cells, in the thoracic intercostal and abdominal muscles, limb muscles and superficial back muscles, as well as the diaphragm and the tip of the tongue http://purl.obolibrary.org/obo/MP_0003360 abnormal depression-related behavior http://purl.obolibrary.org/obo/MP_0002572 abnormal emotion/affect behavior responses to a stressful situation or stimulus, or failure to seek pleasurable stimuli http://purl.obolibrary.org/obo/MP_0003361 abnormal circulating gonadotropin level http://purl.obolibrary.org/obo/MP_0005418 abnormal circulating hormone level aberrant blood concentration of the peptide hormones that stimulate gonadal functions such as gametogenesis and sex steroid hormone production in the ovary and the testis http://purl.obolibrary.org/obo/MP_0003362 increased circulating gonadotropin level http://purl.obolibrary.org/obo/MP_0003361 abnormal circulating gonadotropin level greater than the normal blood concentration of the peptide hormones that stimulate gonadal functions such as gametogenesis and sex steroid hormone production in the ovary and the testis http://purl.obolibrary.org/obo/MP_0003363 decreased circulating gonadotropin level http://purl.obolibrary.org/obo/MP_0003361 abnormal circulating gonadotropin level less than the normal blood concentration of the peptide hormones that stimulate gonadal functions such as gametogenesis and sex steroid hormone production in the ovary and the testis http://purl.obolibrary.org/obo/MP_0003364 increased insulinoma incidence http://purl.obolibrary.org/obo/MP_0003430 increased pancreatic islet cell adenoma incidence greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the pancreatic islet beta cells, occurring in a specific population in a given time period; these tumors secrete excess insulin http://purl.obolibrary.org/obo/MP_0003365 increased glucagonoma incidence http://purl.obolibrary.org/obo/MP_0003430 increased pancreatic islet cell adenoma incidence greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the pancreatic islet alpha cells, occurring in a specific population in a given time period; these tumors secrete excess glucagon http://purl.obolibrary.org/obo/MP_0003366 abnormal circulating glucocorticoid level http://purl.obolibrary.org/obo/MP_0005418 abnormal circulating hormone level aberrant blood concentration of the corticosteroids regulating carbohydrate metabolism and exhibiting anti-inflammatory activity http://purl.obolibrary.org/obo/MP_0003367 increased circulating glucocorticoid level http://purl.obolibrary.org/obo/MP_0003366 abnormal circulating glucocorticoid level greater than normal blood concentration of the corticosteroids regulating carbohydrate metabolism and exhibiting anti-inflammatory activity http://purl.obolibrary.org/obo/MP_0003368 decreased circulating glucocorticoid level http://purl.obolibrary.org/obo/MP_0003366 abnormal circulating glucocorticoid level less than normal blood concentration of the corticosteroids regulating carbohydrate metabolism and exhibiting anti-inflammatory activity http://purl.obolibrary.org/obo/MP_0003369 abnormal circulating estrogen level http://purl.obolibrary.org/obo/MP_0005418 abnormal circulating hormone level aberration in the blood concentration of any substance that causes development of the female reproductive organs and secondary sexual characteristics http://purl.obolibrary.org/obo/MP_0003370 increased circulating estrogen level http://purl.obolibrary.org/obo/MP_0003369 abnormal circulating estrogen level greater than normal blood concentration of any substance that causes development of the female reproductive organs and secondary sexual characteristics http://purl.obolibrary.org/obo/MP_0003371 decreased circulating estrogen level http://purl.obolibrary.org/obo/MP_0003369 abnormal circulating estrogen level reduction in the blood concentration of any substance that causes development of the female reproductive organs and secondary sexual characteristics http://purl.obolibrary.org/obo/MP_0003372 abnormal circulating mineralocorticoid level http://purl.obolibrary.org/obo/MP_0005418 abnormal circulating hormone level aberrant blood concentration of corticosteroids that influence water and electrolyte metabolism and balance http://purl.obolibrary.org/obo/MP_0003373 increased circulating mineralocorticoid level http://purl.obolibrary.org/obo/MP_0003372 abnormal circulating mineralocorticoid level greater than normal blood concentration of corticosteroids that influence water and electrolyte metabolism and balance http://purl.obolibrary.org/obo/MP_0003374 decreased circulating mineralocorticoid level http://purl.obolibrary.org/obo/MP_0003372 abnormal circulating mineralocorticoid level less than normal blood concentration of corticosteroids that influence water and electrolyte metabolism and balance http://purl.obolibrary.org/obo/MP_0003375 abnormal menstrual cycle http://purl.obolibrary.org/obo/MP_0009344 abnormal ovulation cycle failure of or aberrant timing of a recurring cycle in human primates in which the endometrial lining of the uterus prepares for pregnancy and ovulation occurs; if pregnancy does not occur the lining is discharged at menstruation http://purl.obolibrary.org/obo/MP_0003376 amenorrhea http://purl.obolibrary.org/obo/MP_0003375 abnormal menstrual cycle absence or abnormal cessation of the shedding of the endometrium and associated bleeding in primates http://purl.obolibrary.org/obo/MP_0003377 late onset of menarche http://purl.obolibrary.org/obo/MP_0001938 delayed sexual maturation the onset of menstrual cycles occurs at a later age than normal http://purl.obolibrary.org/obo/MP_0003378 early sexual maturation http://purl.obolibrary.org/obo/MP_0001937 abnormal sexual maturation pubertal changes occur at an earlier than normal age http://purl.obolibrary.org/obo/MP_0003379 absent sexual maturation http://purl.obolibrary.org/obo/MP_0001937 abnormal sexual maturation failure to initiate pubertal changes that result in achievement of full sexual capacity http://purl.obolibrary.org/obo/MP_0003380 abnormal intestine regeneration http://purl.obolibrary.org/obo/MP_0010155 abnormal intestine physiology deviation from the normal ability of the intestine to regenerate healthy tissue following injury or disease http://purl.obolibrary.org/obo/MP_0003381 vitreal fibroplasia http://purl.obolibrary.org/obo/MP_0002699 abnormal vitreous body morphology production of excess fibrous tissue in the vitreous body of the eye http://purl.obolibrary.org/obo/MP_0003382 straub tail http://purl.obolibrary.org/obo/MP_0001391 abnormal tail movements condition in which an animal carries its tail in an erect (vertical or nearly vertical) position; often seen upon opioid and other drug treatment http://purl.obolibrary.org/obo/MP_0003383 abnormal gluconeogenesis http://purl.obolibrary.org/obo/MP_0002078 abnormal glucose homeostasis anomaly in the formation of glucose from non-carbohydrates, such as proteins or fat http://purl.obolibrary.org/obo/MP_0003384 abnormal ventral body wall morphology http://purl.obolibrary.org/obo/MP_0003385 abnormal body wall morphology any structural anomaly of the anterior portion of a human body or the lower surface of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity http://purl.obolibrary.org/obo/MP_0003385 abnormal body wall morphology http://purl.obolibrary.org/obo/MP_0005378 growth/size/body phenotype any structural anomaly of the external portion of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity http://purl.obolibrary.org/obo/MP_0003387 aorta coarctation http://purl.obolibrary.org/obo/MP_0000272 abnormal aorta morphology a congenital focal constriction of the aorta most commonly found just distal to the origin of the left subclavian artery; the most commonly found form is juxtaductal coarctation, but it may occur at any point from the transverse arch to the iliac bifurcation http://purl.obolibrary.org/obo/MP_0003388 absent pericardium http://purl.obolibrary.org/obo/MP_0000288 abnormal pericardium morphology absence of the fibroserous membrane covering the heart and beginning of the great vessels http://purl.obolibrary.org/obo/MP_0003389 constriction of pericardium http://purl.obolibrary.org/obo/MP_0000288 abnormal pericardium morphology tightening of the pericardium around the heart http://purl.obolibrary.org/obo/MP_0003390 lymphedema http://purl.obolibrary.org/obo/MP_0001785 edema abnormal swelling in the soft tissues of the limbs, or less often the trunk, caused by the buildup of lymph fluid http://purl.obolibrary.org/obo/MP_0003391 increased myxoma incidence http://purl.obolibrary.org/obo/MP_0010273 increased classified tumor incidence higher than normal incidence of a benign neoplasm derived from pluripotential mesenchymal stem cells of connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix; may show multiple differentiated components http://purl.obolibrary.org/obo/MP_0003392 increased atrial myxoma incidence http://purl.obolibrary.org/obo/MP_0010291 increased cardiovascular system tumor incidence higher than normal incidence of a benign neoplasm derived from pluripotential mesenchymal stem cells of either the left or right atrium connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix; an increase in primary intracardiac tumor incidence http://purl.obolibrary.org/obo/MP_0003393 decreased cardiac output http://purl.obolibrary.org/obo/MP_0001627 abnormal cardiac output reduction in the blood volume pumped by each ventricle per minute http://purl.obolibrary.org/obo/MP_0003394 increased cardiac output http://purl.obolibrary.org/obo/MP_0001627 abnormal cardiac output greater than normal blood volume pumped by each ventricle per minute http://purl.obolibrary.org/obo/MP_0003395 abnormal subclavian artery morphology http://purl.obolibrary.org/obo/MP_0011655 abnormal systemic artery morphology any structural anomaly of the right or left subclavian arteries; the right subclavian artery normally extends from the brachiocephalic artery to the right side of the body and the left subclavian artery extends from the aortic arch to the left side of the body http://purl.obolibrary.org/obo/MP_0003396 abnormal embryonic hematopoiesis http://purl.obolibrary.org/obo/MP_0002429 abnormal blood cell morphology/development anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages that circulate in the embryonic and extraembryonic tissues, and which occurs in blood islands in the yolk sac from E7-E11 in the mouse and through 10 weeks in humans http://purl.obolibrary.org/obo/MP_0003397 increased muscle weight http://purl.obolibrary.org/obo/MP_0004233 abnormal muscle weight greater than average muscle weight http://purl.obolibrary.org/obo/MP_0003398 increased skeletal muscle size http://purl.obolibrary.org/obo/MP_0009458 abnormal skeletal muscle size greater than average dimensions of one or more of the muscles of the skeleton http://purl.obolibrary.org/obo/MP_0003400 kinked neural tube http://purl.obolibrary.org/obo/MP_0002151 abnormal neural tube morphology/development twists or kinks in the embryonic neural tube http://purl.obolibrary.org/obo/MP_0003401 enlarged tail bud http://purl.obolibrary.org/obo/MP_0002861 abnormal tail bud morphology increased size or area of the primordial region of the embryo that arises to form the tail of the adult http://purl.obolibrary.org/obo/MP_0003402 decreased liver weight http://purl.obolibrary.org/obo/MP_0004847 abnormal liver weight reduced average weight of the bile-secreting exocrine gland http://purl.obolibrary.org/obo/MP_0003403 absent placental labyrinth http://purl.obolibrary.org/obo/MP_0001716 abnormal placenta labyrinth morphology absence of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood http://purl.obolibrary.org/obo/MP_0003404 absent enamel http://purl.obolibrary.org/obo/MP_0002576 abnormal enamel morphology absence of the hard outer coating of the exposed portion of the tooth http://purl.obolibrary.org/obo/MP_0003405 abnormal platelet shape http://purl.obolibrary.org/obo/MP_0004720 abnormal platelet morphology any anomaly in the characteristic surface outline or contour of the normal small, disk-like shape of blood plasma cells derived from megakaryocytes and which function to promote blood clotting http://purl.obolibrary.org/obo/MP_0003406 failure of zygotic cell division http://purl.obolibrary.org/obo/MP_0009781 abnormal preimplantation embryo development inability of a fertilized oocyte to initiate or complete early cell divisions http://purl.obolibrary.org/obo/MP_0003407 abnormal central nervous system regeneration http://purl.obolibrary.org/obo/MP_0004858 abnormal nervous system regeneration changes in the ability or inability of healthy central nervous system tissue to regenerate following injury or disease http://purl.obolibrary.org/obo/MP_0003408 increased width of hypertrophic chondrocyte zone http://purl.obolibrary.org/obo/MP_0000165 abnormal long bone hypertrophic chondrocyte zone increased width of cartilage cell matrix layer http://purl.obolibrary.org/obo/MP_0003409 decreased width of hypertrophic chondrocyte zone http://purl.obolibrary.org/obo/MP_0000165 abnormal long bone hypertrophic chondrocyte zone decreased width of cartilage cell matrix layer http://purl.obolibrary.org/obo/MP_0003410 abnormal artery development http://purl.obolibrary.org/obo/MP_0002191 abnormal artery morphology anomaly in the process of forming the blood vessels that carry blood away from the heart http://purl.obolibrary.org/obo/MP_0003411 abnormal vein development http://purl.obolibrary.org/obo/MP_0002725 abnormal vein morphology anomaly in the process of forming the blood vessels that carry blood to the heart http://purl.obolibrary.org/obo/MP_0003412 abnormal afterhyperpolarization http://purl.obolibrary.org/obo/MP_0002272 abnormal nervous system electrophysiology anomaly in the currents that follow an action potential and influence firing frequency and neuronal integration http://purl.obolibrary.org/obo/MP_0003413 hair follicle degeneration http://purl.obolibrary.org/obo/MP_0000377 abnormal hair follicle morphology a retrogressive impairment of function or destruction of the hair follicle http://purl.obolibrary.org/obo/MP_0003414 epidermal cyst http://purl.obolibrary.org/obo/MP_0001191 abnormal skin condition a benign mass derived from the epidermis or the epithelium of a hair follicle, formed by enclosure of epithelium within the dermis and filled with keratin and lipid-rich inclusions http://purl.obolibrary.org/obo/MP_0003415 priapism http://purl.obolibrary.org/obo/MP_0001379 abnormal penile erection prolonged penile erection, often painful and without sexual desire http://purl.obolibrary.org/obo/MP_0003416 premature bone ossification http://purl.obolibrary.org/obo/MP_0008271 abnormal bone ossification early onset of the formation of bone http://purl.obolibrary.org/obo/MP_0003417 premature endochondral bone ossification http://purl.obolibrary.org/obo/MP_0008272 abnormal endochondral bone ossification early onset of bone formation in bones that form from cartilage http://purl.obolibrary.org/obo/MP_0003418 premature intramembranous bone ossification http://purl.obolibrary.org/obo/MP_0008273 abnormal intramembranous bone ossification early onset of bone formation in bones that form without a cartilaginous intermediate including the cranium and clavicle http://purl.obolibrary.org/obo/MP_0003419 delayed endochondral bone ossification http://purl.obolibrary.org/obo/MP_0008272 abnormal endochondral bone ossification late onset of bone formation in bones that form from cartilage http://purl.obolibrary.org/obo/MP_0003420 delayed intramembranous bone ossification http://purl.obolibrary.org/obo/MP_0008273 abnormal intramembranous bone ossification late onset of bone formation in bones that form without a cartilaginous intermediate including the cranium and clavicle http://purl.obolibrary.org/obo/MP_0003421 abnormal thyroid gland development http://purl.obolibrary.org/obo/MP_0000681 abnormal thyroid gland morphology failure or abnormality in the formation of the thyroid gland during organogenesis http://purl.obolibrary.org/obo/MP_0003422 abnormal thrombolysis http://purl.obolibrary.org/obo/MP_0002551 abnormal blood coagulation altered ability to break up (lyse) blood clots that are restricting the blood flow http://purl.obolibrary.org/obo/MP_0003423 reduced thrombolysis http://purl.obolibrary.org/obo/MP_0003422 abnormal thrombolysis reduced ability or inability to break up (lyse) blood clots that are restricting the blood flow http://purl.obolibrary.org/obo/MP_0003424 premature neuronal precursor differentiation http://purl.obolibrary.org/obo/MP_0009937 abnormal neuron differentiation earlier than normal transformation of neuronal precursor cells into neurons http://purl.obolibrary.org/obo/MP_0003425 abnormal optic vesicle formation http://purl.obolibrary.org/obo/MP_0001286 abnormal eye development anomalous formation of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop http://purl.obolibrary.org/obo/MP_0003426 pulmonary interstitial fibrosis http://purl.obolibrary.org/obo/MP_0006050 pulmonary fibrosis formation of fibrous tissue within the interstices of the lung as a result of repair or a reactive process http://purl.obolibrary.org/obo/MP_0003427 parakeratosis http://purl.obolibrary.org/obo/MP_0001242 hyperkeratosis thickening of the stratum corneum of the epidermis (hyperkeratosis) with nucleated keratinocytes retained in this layer http://purl.obolibrary.org/obo/MP_0003429 insensitivity to growth hormone http://purl.obolibrary.org/obo/MP_0003638 abnormal response/metabolism to endogenous compounds no growth response to exogenous growth hormone http://purl.obolibrary.org/obo/MP_0003430 increased pancreatic islet cell adenoma incidence http://purl.obolibrary.org/obo/MP_0009043 increased pancreas adenoma incidence greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the islet cells of the pancreas, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0003431 abnormal parathyroid gland physiology http://purl.obolibrary.org/obo/MP_0002164 abnormal gland physiology any functional anomaly of this paired endocrine gland that normally produces parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism http://purl.obolibrary.org/obo/MP_0003432 increased activity of parathyroid http://purl.obolibrary.org/obo/MP_0003431 abnormal parathyroid gland physiology increased function of this paired endocrine gland that normally produces parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism http://purl.obolibrary.org/obo/MP_0003433 decreased activity of parathyroid http://purl.obolibrary.org/obo/MP_0003431 abnormal parathyroid gland physiology reduced function of this paired endocrine gland that normally produces parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism http://purl.obolibrary.org/obo/MP_0003434 decreased susceptibility to induced choroidal neovascularization http://purl.obolibrary.org/obo/MP_0005546 choroidal neovascularization reduction or absence of growth of new, abnormal blood vessels that originate in the choroid through a break in the Bruch membrane into the sub-retinal pigment epithelium or subretinal space and may result in visual loss as a result of chemical or mechanical manipulation (e.g. laser-induced trauma) http://purl.obolibrary.org/obo/MP_0003435 herniated seminal vesicle http://purl.obolibrary.org/obo/MP_0002059 abnormal seminal vesicle morphology protrusion of the seminal vesicles through the pelvic outlet http://purl.obolibrary.org/obo/MP_0003436 decreased susceptibility to induced arthritis http://purl.obolibrary.org/obo/MP_0005351 decreased susceptibility to autoimmune disorder less likely to be stricken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents http://purl.obolibrary.org/obo/MP_0003437 abnormal carotid body morphology http://purl.obolibrary.org/obo/MP_0004181 abnormal carotid artery morphology any structural anomaly of a small epithelioid structure consisting of a small cluster of chemoreceptive and supporting cells located near the bifurcation of the common carotid artery that serves as a chemoreceptive organ that senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control http://purl.obolibrary.org/obo/MP_0003438 abnormal carotid body physiology http://purl.obolibrary.org/obo/MP_0010055 abnormal sensory neuron physiology any functional anomaly in a small epithelioid structure consisting of a small cluster of chemoreceptive and supporting cells located near the bifurcation of the common carotid artery that serves as a chemoreceptive organ that senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control http://purl.obolibrary.org/obo/MP_0003439 abnormal glycerol level http://purl.obolibrary.org/obo/MP_0001547 abnormal lipid level abnormal level of trihydroxy sugar alcohols that are precursors for synthesis of triacylglycerols, and of phospholipids and cellular glucose in the liver and adipose tissue; fat catabolism results in the release of glycerol and fatty acids into the bloodstream to be used as an energy source http://purl.obolibrary.org/obo/MP_0003440 decreased glycerol level http://purl.obolibrary.org/obo/MP_0003439 abnormal glycerol level reduced level of trihydroxy sugar alcohols that are precursors for synthesis of triacylglycerols, and of phospholipids and cellular glucose in the liver and adipose tissue; fat catabolism results in the release of glycerol and fatty acids into the bloodstream to be used as an energy source http://purl.obolibrary.org/obo/MP_0003441 increased glycerol level http://purl.obolibrary.org/obo/MP_0003439 abnormal glycerol level elevated level of trihydroxy sugar alcohols that are precursors for synthesis of triacylglycerols, and of phospholipids and cellular glucose in the liver and adipose tissue; fat catabolism results in the release of glycerol and fatty acids into the bloodstream to be used as an energy source http://purl.obolibrary.org/obo/MP_0003442 decreased circulating glycerol level http://purl.obolibrary.org/obo/MP_0011973 abnormal circulating glycerol level reduced blood level of trihydroxy sugar alcohols that are precursors for synthesis of triacylglycerols, and of phospholipids and cellular glucose in the liver and adipose tissue; fat catabolism results in the release of glycerol and fatty acids into the bloodstream to be used as an energy source http://purl.obolibrary.org/obo/MP_0003443 increased circulating glycerol level http://purl.obolibrary.org/obo/MP_0011973 abnormal circulating glycerol level elevated blood level of trihydroxy sugar alcohols that are precursors for synthesis of triacylglycerols, and of phospholipids and cellular glucose in the liver and adipose tissue; fat catabolism results in the release of glycerol and fatty acids into the bloodstream to be used as an energy source http://purl.obolibrary.org/obo/MP_0003444 abnormal neurotransmitter uptake http://purl.obolibrary.org/obo/MP_0002204 abnormal neurotransmitter level aberration in the reabsorbtion of endogenous signaling molecules released into a synaptic cleft; neurotransmitters are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell http://purl.obolibrary.org/obo/MP_0003445 sirenomelia http://purl.obolibrary.org/obo/MP_0006279 abnormal limb development fusion of the caudal-most (posterior or lower) limbs often with partial or complete fusion of the autopods http://purl.obolibrary.org/obo/MP_0003446 renal hypoplasia http://purl.obolibrary.org/obo/MP_0002989 small kidney underdevelopment or reduced size of the kidney, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0003447 decreased tumor growth/size http://purl.obolibrary.org/obo/MP_0003448 altered tumor morphology less than expected development of tumorous growth when compared to controls http://purl.obolibrary.org/obo/MP_0003448 altered tumor morphology http://purl.obolibrary.org/obo/MP_0010639 altered tumor pathology any structural anomaly of a given tumor type compared to controls http://purl.obolibrary.org/obo/MP_0003449 abnormal intestinal goblet cell morphology http://purl.obolibrary.org/obo/MP_0000511 abnormal intestinal mucosa morphology any structural anomaly of a goblet cell that is part of the epithelium of intestinal villus http://purl.obolibrary.org/obo/MP_0003450 enlarged pancreas http://purl.obolibrary.org/obo/MP_0009106 abnormal pancreas size increase of the size of the pancreas compared to controls http://purl.obolibrary.org/obo/MP_0003451 absent olfactory bulb http://purl.obolibrary.org/obo/MP_0000819 abnormal olfactory bulb morphology absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex http://purl.obolibrary.org/obo/MP_0003452 abnormal parotid gland morphology http://purl.obolibrary.org/obo/MP_0003792 abnormal major salivary gland morphology any structural anomaly of either of the largest of the major salivary glands situated below and in front of each ear http://purl.obolibrary.org/obo/MP_0003453 abnormal keratinocyte physiology http://purl.obolibrary.org/obo/MP_0005501 abnormal skin physiology abnormal function of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum http://purl.obolibrary.org/obo/MP_0003454 erythroderma http://purl.obolibrary.org/obo/MP_0001194 dermatitis exfoliation and widespread, intense reddening of the skin due to inflammatory skin disease http://purl.obolibrary.org/obo/MP_0003455 decreased susceptibility to induced retinal damage http://purl.obolibrary.org/obo/MP_0001325 abnormal retina morphology reduced or absent pathological changes in the retina due to chemical or mechanical agents http://purl.obolibrary.org/obo/MP_0003456 absent tail http://purl.obolibrary.org/obo/MP_0002111 abnormal tail morphology completely lacking the appendage at the caudal end of the vertebral column http://purl.obolibrary.org/obo/MP_0003457 abnormal circulating ketone body level http://purl.obolibrary.org/obo/MP_0009642 abnormal blood homeostasis aberrant amount of acetoacetate, 3-hydroxybutyrate (beta-hydroxybutyrate) and/or acteone in the blood, which are produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus http://purl.obolibrary.org/obo/MP_0003458 decreased circulating ketone body level http://purl.obolibrary.org/obo/MP_0003457 abnormal circulating ketone body level less than the normal amount of acetoacetate, 3-hydroxybutyrate (beta-hydroxybutyrate) and/or acteone in the blood, which are produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus http://purl.obolibrary.org/obo/MP_0003459 increased fear-related response http://purl.obolibrary.org/obo/MP_0003106 abnormal fear-related response greater emotional response related to anticipation of specific pain or danger http://purl.obolibrary.org/obo/MP_0003460 decreased fear-related response http://purl.obolibrary.org/obo/MP_0003106 abnormal fear-related response reduced emotional response related to anticipation of specific pain or danger http://purl.obolibrary.org/obo/MP_0003461 abnormal response to novel object http://purl.obolibrary.org/obo/MP_0003107 abnormal response to novelty altered behavioral reaction associated with exposing an animal to a novel object http://purl.obolibrary.org/obo/MP_0003462 abnormal response to novel odor http://purl.obolibrary.org/obo/MP_0003107 abnormal response to novelty altered behavioral reaction associated with exposing an animal to a novel odor http://purl.obolibrary.org/obo/MP_0003463 abnormal single cell response http://purl.obolibrary.org/obo/MP_0002272 abnormal nervous system electrophysiology altered values from controls obtained upon extra- or intracellular recordings from single cells http://purl.obolibrary.org/obo/MP_0003464 abnormal single cell response threshold http://purl.obolibrary.org/obo/MP_0003463 abnormal single cell response any change in the value at which a stimulus first elicits a recordable response recorded in a single cell http://purl.obolibrary.org/obo/MP_0003465 increased single cell response threshold http://purl.obolibrary.org/obo/MP_0003464 abnormal single cell response threshold increase in the value at which a stimulus first elicits a recordable response recorded in a single cell http://purl.obolibrary.org/obo/MP_0003466 decreased single cell response threshold http://purl.obolibrary.org/obo/MP_0003464 abnormal single cell response threshold reduction in the value at which a stimulus first elicits a recordable response recorded in a single cell http://purl.obolibrary.org/obo/MP_0003467 abnormal single cell response intensity http://purl.obolibrary.org/obo/MP_0003463 abnormal single cell response any change in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in a single cell http://purl.obolibrary.org/obo/MP_0003468 increased single cell response intensity http://purl.obolibrary.org/obo/MP_0003467 abnormal single cell response intensity increase in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in a single cell http://purl.obolibrary.org/obo/MP_0003469 decreased single cell response intensity http://purl.obolibrary.org/obo/MP_0003467 abnormal single cell response intensity reduction in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in a single cell http://purl.obolibrary.org/obo/MP_0003470 abnormal summary potential http://purl.obolibrary.org/obo/MP_0002272 abnormal nervous system electrophysiology anomaly in the electrophysiological recording of the activity of several cells http://purl.obolibrary.org/obo/MP_0003471 abnormal summary potential threshold http://purl.obolibrary.org/obo/MP_0003470 abnormal summary potential any change in the value at which a stimulus first elicits a recordable response recorded in several cells or a tissue slice http://purl.obolibrary.org/obo/MP_0003472 increased summary potential threshold http://purl.obolibrary.org/obo/MP_0003471 abnormal summary potential threshold increase in the value at which a stimulus first elicits a recordable response recorded in several cells or a tissue slice http://purl.obolibrary.org/obo/MP_0003473 decreased summary potential threshold http://purl.obolibrary.org/obo/MP_0003471 abnormal summary potential threshold reduction in the value at which a stimulus first elicits a recordable response recorded in several cells or a tissue slice http://purl.obolibrary.org/obo/MP_0003474 abnormal summary potential intensity http://purl.obolibrary.org/obo/MP_0003470 abnormal summary potential any change in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in several cells or a tissue slice http://purl.obolibrary.org/obo/MP_0003475 increased summary potential intensity http://purl.obolibrary.org/obo/MP_0003474 abnormal summary potential intensity increase in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in several cells or a tissue slice http://purl.obolibrary.org/obo/MP_0003476 decreased summary potential intensity http://purl.obolibrary.org/obo/MP_0003474 abnormal summary potential intensity reduction in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in several cells or a tissue slice http://purl.obolibrary.org/obo/MP_0003477 abnormal nerve fiber response http://purl.obolibrary.org/obo/MP_0002272 abnormal nervous system electrophysiology anomaly in the electrophysiological recordings from a single or several nerve fiber(s) http://purl.obolibrary.org/obo/MP_0003478 abnormal nerve fiber response threshold http://purl.obolibrary.org/obo/MP_0003477 abnormal nerve fiber response any change in the value at which a stimulus first elicits a recordable response recorded in a single or several nerve fiber(s) http://purl.obolibrary.org/obo/MP_0003479 abnormal nerve fiber response intensity http://purl.obolibrary.org/obo/MP_0003477 abnormal nerve fiber response any change in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in a single or several nerve fiber(s) http://purl.obolibrary.org/obo/MP_0003480 increased nerve fiber response intensity http://purl.obolibrary.org/obo/MP_0003479 abnormal nerve fiber response intensity increase in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in a single or several nerve fiber(s) http://purl.obolibrary.org/obo/MP_0003481 decreased nerve fiber response intensity http://purl.obolibrary.org/obo/MP_0003479 abnormal nerve fiber response intensity reduction in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in a single or several nerve fiber(s) http://purl.obolibrary.org/obo/MP_0003482 increased nerve fiber response threshold http://purl.obolibrary.org/obo/MP_0003478 abnormal nerve fiber response threshold increase in the value at which a stimulus first elicits a recordable response recorded in a single or several nerve fiber(s) http://purl.obolibrary.org/obo/MP_0003483 decreased nerve fiber response threshold http://purl.obolibrary.org/obo/MP_0003478 abnormal nerve fiber response threshold reduction in the value at which a stimulus first elicits a recordable response recorded in a single or several nerve fiber(s) http://purl.obolibrary.org/obo/MP_0003484 abnormal channel response http://purl.obolibrary.org/obo/MP_0003635 abnormal synaptic transmission anomalies in the electrophysiological recordings from ion channels http://purl.obolibrary.org/obo/MP_0003485 abnormal channel response threshold http://purl.obolibrary.org/obo/MP_0003484 abnormal channel response any change in the value at which a stimulus first elicits a recordable response recorded from ion channels http://purl.obolibrary.org/obo/MP_0003486 abnormal channel response intensity http://purl.obolibrary.org/obo/MP_0003484 abnormal channel response any change in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded from ion channels http://purl.obolibrary.org/obo/MP_0003487 increased channel response intensity http://purl.obolibrary.org/obo/MP_0003486 abnormal channel response intensity increase in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded from ion channels http://purl.obolibrary.org/obo/MP_0003488 decreased channel response intensity http://purl.obolibrary.org/obo/MP_0003486 abnormal channel response intensity reduction in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded from ion channels http://purl.obolibrary.org/obo/MP_0003489 increased channel response threshold http://purl.obolibrary.org/obo/MP_0003485 abnormal channel response threshold increase in the value at which a stimulus first elicits a recordable response recorded from ion channels http://purl.obolibrary.org/obo/MP_0003490 decreased channel response threshold http://purl.obolibrary.org/obo/MP_0003485 abnormal channel response threshold reduction in the value at which a stimulus first elicits a recordable response recorded from ion channels http://purl.obolibrary.org/obo/MP_0003491 abnormal voluntary movement http://purl.obolibrary.org/obo/MP_0002066 abnormal motor capabilities/coordination/movement anomaly in coordinated movements executed with a purpose and can be improved by learning and/or experience http://purl.obolibrary.org/obo/MP_0003492 abnormal involuntary movement http://purl.obolibrary.org/obo/MP_0002066 abnormal motor capabilities/coordination/movement anomaly in movements that occur independent of planning (e.g. reflexive behavior) http://purl.obolibrary.org/obo/MP_0003493 parathyroid gland hyperplasia http://purl.obolibrary.org/obo/MP_0003112 enlarged parathyroid gland overdevelopment or increased size, usually due an increased number of cells of one of the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; they secrete parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism http://purl.obolibrary.org/obo/MP_0003494 parathyroid hypoplasia http://purl.obolibrary.org/obo/MP_0003113 small parathyroid gland underdevelopment or reduced size, usually due to a reduced number of cells, of one of the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; they secrete parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism http://purl.obolibrary.org/obo/MP_0003495 increased parathyroid adenoma incidence http://purl.obolibrary.org/obo/MP_0010383 increased adenoma incidence greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the parathyroid gland, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0003496 increased thyroid adenoma incidence http://purl.obolibrary.org/obo/MP_0010383 increased adenoma incidence greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the thyroid gland, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0003497 insensitivity to parathyroid hormone http://purl.obolibrary.org/obo/MP_0003638 abnormal response/metabolism to endogenous compounds no changes in calcium homeostasis in response to endogenous or exogenous hormone http://purl.obolibrary.org/obo/MP_0003498 thyroid gland hyperplasia http://purl.obolibrary.org/obo/MP_0005355 enlarged thyroid gland overdevelopment or increased size, usually due an increased number of cells of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin http://purl.obolibrary.org/obo/MP_0003499 thyroid hypoplasia http://purl.obolibrary.org/obo/MP_0002951 small thyroid gland underdevelopment or reduced size, usually due to a reduced number of cells, of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin http://purl.obolibrary.org/obo/MP_0003501 iodide oxidation defect http://purl.obolibrary.org/obo/MP_0002876 abnormal thyroid physiology thyroid defect in oxidation and organification of iodide http://purl.obolibrary.org/obo/MP_0003502 increased activity of thyroid http://purl.obolibrary.org/obo/MP_0002876 abnormal thyroid physiology increased function of this endocrine gland that normally produces hormones that regulate the metabolic rate of the body http://purl.obolibrary.org/obo/MP_0003503 decreased activity of thyroid http://purl.obolibrary.org/obo/MP_0002876 abnormal thyroid physiology reduced function of this endocrine gland that normally produces hormones that regulate the metabolic rate of the body http://purl.obolibrary.org/obo/MP_0003504 thyroid inflammation http://purl.obolibrary.org/obo/MP_0002876 abnormal thyroid physiology local accumulation of fluid, plasma proteins, and leukocytes in the thyroid gland http://purl.obolibrary.org/obo/MP_0003505 increased prolactinoma incidence http://purl.obolibrary.org/obo/MP_0010350 increased pituitary adenohypophysis tumor incidence greater than the expected number of a pituitary adenoma characterized by secretion of prolactin, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0003506 acromegaly http://purl.obolibrary.org/obo/MP_0001746 abnormal pituitary secretion excessive secretion of growth hormone resulting in progressive enlargement of the face, hands, feet, head, and thorax; organomegaly and impaired glucose homeostasis may ensue http://purl.obolibrary.org/obo/MP_0003507 abnormal ovary physiology http://purl.obolibrary.org/obo/MP_0013326 abnormal female reproductive gland physiology any functional anomaly of the ovarian follicle for the production of female germ cells or the endocrine cells for the production of estrogen and progesterone http://purl.obolibrary.org/obo/MP_0003508 abnormal circulating dihydrotestosterone level http://purl.obolibrary.org/obo/MP_0009819 abnormal circulating androgen level aberration in the blood concentration of a potent androgenic metabolite of testosterone http://purl.obolibrary.org/obo/MP_0003509 increased circulating dihydrotestosterone level http://purl.obolibrary.org/obo/MP_0003508 abnormal circulating dihydrotestosterone level greater than normal blood concentration of this potent androgenic metabolite of testosterone http://purl.obolibrary.org/obo/MP_0003510 decreased circulating dihydrotestosterone level http://purl.obolibrary.org/obo/MP_0003508 abnormal circulating dihydrotestosterone level reduction in the blood concentration of a potent androgenic metabolite of testosterone http://purl.obolibrary.org/obo/MP_0003511 abnormal labium morphology http://purl.obolibrary.org/obo/MP_0003126 abnormal external female genitalia morphology any structural anomaly of the folds of skin which form the inner lips (labia minora) and outer lips (labia majora) on both sides of the vaginal opening http://purl.obolibrary.org/obo/MP_0003512 enlarged labia http://purl.obolibrary.org/obo/MP_0003511 abnormal labium morphology increased size of the folds of skin which form the inner lips (labia minora) and outer lips (labia majora) on both sides of the vaginal opening http://purl.obolibrary.org/obo/MP_0003513 small labia http://purl.obolibrary.org/obo/MP_0003511 abnormal labium morphology decreased size of the folds of skin which form the inner lips (labia minora) and outer lips (labia majora) on both sides of the vaginal opening http://purl.obolibrary.org/obo/MP_0003514 interlabial sulcus http://purl.obolibrary.org/obo/MP_0003511 abnormal labium morphology the presence of grooves or furrows in the folds of skin which lips on both sides of the vaginal opening http://purl.obolibrary.org/obo/MP_0003515 abnormal labia majora morphology http://purl.obolibrary.org/obo/MP_0003511 abnormal labium morphology any structural anomaly of the folds of skin which form the outer lips (labia majora) on both sides of the vaginal opening http://purl.obolibrary.org/obo/MP_0003516 absent labia majora http://purl.obolibrary.org/obo/MP_0003515 abnormal labia majora morphology absence of the folds of skin which form the outer lips (labia majora) on both sides of the vaginal opening http://purl.obolibrary.org/obo/MP_0003517 enlarged labia majora http://purl.obolibrary.org/obo/MP_0003515 abnormal labia majora morphology increased size of the folds of skin which form the outer lips (labia majora) on both sides of the vaginal opening http://purl.obolibrary.org/obo/MP_0003518 small labia majora http://purl.obolibrary.org/obo/MP_0003515 abnormal labia majora morphology reduced size of the folds of skin which form the outer lips (labia majora) on both sides of the vaginal opening http://purl.obolibrary.org/obo/MP_0003519 splayed labia majora http://purl.obolibrary.org/obo/MP_0003515 abnormal labia majora morphology flattened or spread out appearance of the folds of skin which form the outer lips (labia majora) on both sides of the vaginal opening http://purl.obolibrary.org/obo/MP_0003520 abnormal labia minora morphology http://purl.obolibrary.org/obo/MP_0003511 abnormal labium morphology any structural anomaly of the folds of skin which form the inner lips (labia minora) on both sides of the vaginal opening http://purl.obolibrary.org/obo/MP_0003521 absent labia minora http://purl.obolibrary.org/obo/MP_0003520 abnormal labia minora morphology absence of the folds of skin which form the inner lips (labia minora) on both sides of the vaginal opening http://purl.obolibrary.org/obo/MP_0003522 enlarged labia minora http://purl.obolibrary.org/obo/MP_0003520 abnormal labia minora morphology increased size of the folds of skin which form the inner lips (labia minora) on both sides of the vaginal opening http://purl.obolibrary.org/obo/MP_0003523 small labia minora http://purl.obolibrary.org/obo/MP_0003520 abnormal labia minora morphology reduced size of the folds of skin which form the inner lips (labia minora) on both sides of the vaginal opening http://purl.obolibrary.org/obo/MP_0003524 splayed labia minora http://purl.obolibrary.org/obo/MP_0003520 abnormal labia minora morphology flattened or spread out appearance of the folds of skin which form the inner lips (labia minora) on both sides of the vaginal opening http://purl.obolibrary.org/obo/MP_0003525 vulva warts http://purl.obolibrary.org/obo/MP_0003126 abnormal external female genitalia morphology benign epithelial growths of the external genitalia of the female http://purl.obolibrary.org/obo/MP_0003526 vulva cysts http://purl.obolibrary.org/obo/MP_0003126 abnormal external female genitalia morphology cystic vulva; usually refers to a benign growth http://purl.obolibrary.org/obo/MP_0003527 small vulva http://purl.obolibrary.org/obo/MP_0003126 abnormal external female genitalia morphology decreased size of the external genitalia of the female http://purl.obolibrary.org/obo/MP_0003528 enlarged vulva http://purl.obolibrary.org/obo/MP_0003126 abnormal external female genitalia morphology increased size of the external genitalia of the female http://purl.obolibrary.org/obo/MP_0003529 enlarged clitoris http://purl.obolibrary.org/obo/MP_0009100 abnormal clitoris size increased size of the small, erectile body located at the anterior end of the vulva http://purl.obolibrary.org/obo/MP_0003530 small clitoris http://purl.obolibrary.org/obo/MP_0009100 abnormal clitoris size reduced size of the small, erectile body located at the anterior end of the vulva http://purl.obolibrary.org/obo/MP_0003531 abnormal vagina development http://purl.obolibrary.org/obo/MP_0003936 abnormal reproductive system development abnormal morphogenesis of the female reproductive canal located between the uterus and the vulva http://purl.obolibrary.org/obo/MP_0003533 bifid vagina http://purl.obolibrary.org/obo/MP_0001139 abnormal vagina morphology cleft of the female reproductive canal located between the uterus and the vulva into two parts or branches http://purl.obolibrary.org/obo/MP_0003534 blind vagina http://purl.obolibrary.org/obo/MP_0001139 abnormal vagina morphology presence the female reproductive canal that ends in a sac and does not connect to internal genitalia http://purl.obolibrary.org/obo/MP_0003535 absent vagina http://purl.obolibrary.org/obo/MP_0001139 abnormal vagina morphology absence of the female reproductive canal located between the uterus and the vulva http://purl.obolibrary.org/obo/MP_0003536 vagina dryness http://purl.obolibrary.org/obo/MP_0001139 abnormal vagina morphology lack of the normal presence or reduced presence of secretions in the vagina http://purl.obolibrary.org/obo/MP_0003537 hydrometrocolpos http://purl.obolibrary.org/obo/MP_0001139 abnormal vagina morphology collection of fluid in the vagina; often due to a congenital obstruction http://purl.obolibrary.org/obo/MP_0003538 abnormal hymen development http://purl.obolibrary.org/obo/MP_0001142 abnormal vagina orifice morphology anomaly in the morphogenesis of the thin membrane which may partially occlude the opening of the vagina; often absent in normal females http://purl.obolibrary.org/obo/MP_0003539 absent hymen http://purl.obolibrary.org/obo/MP_0003538 abnormal hymen development absence of the thin membrane which may partially occlude the opening of the vagina http://purl.obolibrary.org/obo/MP_0003540 imperforate hymen http://purl.obolibrary.org/obo/MP_0003538 abnormal hymen development absence of the normal opening of the thin membrane which may partially occlude the opening of the vagina; here the opening is completely occluded http://purl.obolibrary.org/obo/MP_0003541 vaginal inflammation http://purl.obolibrary.org/obo/MP_0002254 reproductive system inflammation local accumulation of fluid, plasma proteins, and leukocytes in the vagina http://purl.obolibrary.org/obo/MP_0003542 abnormal vascular endothelial cell development http://purl.obolibrary.org/obo/MP_0000259 abnormal vascular development anomaly in the differentiation of the cells that line the vasculature http://purl.obolibrary.org/obo/MP_0003543 abnormal vascular endothelial cell differentiation http://purl.obolibrary.org/obo/MP_0005076 abnormal cell differentiation anomaly in the process whereby a relatively unspecialized cell acquires specialized features of an endothelial cell http://purl.obolibrary.org/obo/MP_0003544 abnormal vascular endothelial cell migration http://purl.obolibrary.org/obo/MP_0003542 abnormal vascular endothelial cell development anomaly in the movement of endothelial cell or their precursors to the appropriate location in the body http://purl.obolibrary.org/obo/MP_0003545 increased alcohol consumption http://purl.obolibrary.org/obo/MP_0011941 increased fluid intake greater than normal consumption of alcohol http://purl.obolibrary.org/obo/MP_0003546 decreased alcohol consumption http://purl.obolibrary.org/obo/MP_0011942 decreased fluid intake less than normal consumption of alcohol http://purl.obolibrary.org/obo/MP_0003547 abnormal pulmonary pressure http://purl.obolibrary.org/obo/MP_0001544 abnormal cardiovascular system physiology altered tension of the blood within the pulmonary arteries http://purl.obolibrary.org/obo/MP_0003548 pulmonary hypertension http://purl.obolibrary.org/obo/MP_0004012 increased pulmonary artery pressure sustained high pulmonary pressure at a level that is likely to result in disease and/or other pathological states http://purl.obolibrary.org/obo/MP_0003549 pulmonary hypotension http://purl.obolibrary.org/obo/MP_0004013 decreased pulmonary artery pressure sustained low pulmonary pressure at a level that is likely to result in disease and/or other pathological states http://purl.obolibrary.org/obo/MP_0003550 short perineum http://purl.obolibrary.org/obo/MP_0005189 abnormal anogenital distance reduced length of the area between the genital organs and the anus that lies beneath the pelvic diaphragm http://purl.obolibrary.org/obo/MP_0003551 blind perineal pouch http://purl.obolibrary.org/obo/MP_0003315 abnormal perineum morphology opening in the perineum leading to a blind-ending sac http://purl.obolibrary.org/obo/MP_0003552 vagina cysts http://purl.obolibrary.org/obo/MP_0001139 abnormal vagina morphology benign epithelial growths of the female reproductive canal located between the uterus and the vulva http://purl.obolibrary.org/obo/MP_0003553 abnormal foreskin morphology http://purl.obolibrary.org/obo/MP_0005187 abnormal penis morphology any structural anomaly of the loose fold of skin that covers the penis http://purl.obolibrary.org/obo/MP_0003554 phimosis http://purl.obolibrary.org/obo/MP_0005187 abnormal penis morphology inability of the penis to protrude from the prepuce/foreskin; may be due to a narrow opening of the foreskin resulting in the inability to retract the distal foreskin over the glans penis http://purl.obolibrary.org/obo/MP_0003555 chordee http://purl.obolibrary.org/obo/MP_0001379 abnormal penile erection acute angulation of the penis upon erection; often painful and due to disease or congenital malformation http://purl.obolibrary.org/obo/MP_0003557 absent vas deferens http://purl.obolibrary.org/obo/MP_0002769 abnormal vas deferens morphology absence of the secretory duct of the testicle that carries spermatozoa, running from the epididymis, of which it is the continuation, to the prostatic urethra where it terminates to form ejaculatory duct http://purl.obolibrary.org/obo/MP_0003558 absent uterus http://purl.obolibrary.org/obo/MP_0001120 abnormal uterus morphology absence of the female muscular organ of gestation http://purl.obolibrary.org/obo/MP_0003559 bifid uterus http://purl.obolibrary.org/obo/MP_0001120 abnormal uterus morphology cleft of the female muscular organ of gestation into two parts or branches, often having the appearance of two lobes http://purl.obolibrary.org/obo/MP_0003560 osteoarthritis http://purl.obolibrary.org/obo/MP_0002993 arthritis a type of arthritis that results in the breakdown and eventual loss of the auricular cartilage of one or more joints http://purl.obolibrary.org/obo/MP_0003561 rheumatoid arthritis http://purl.obolibrary.org/obo/MP_0002993 arthritis an autoimmune response that primarily affects connective tissue; it also results in chronic inflammation of the joints, especially of the hands and feet and may also cause inflammation of the tissue around the joints, as well as other organs in the body http://purl.obolibrary.org/obo/MP_0003562 abnormal pancreatic beta cell physiology http://purl.obolibrary.org/obo/MP_0010147 abnormal endocrine pancreas physiology anomaly in the function of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas http://purl.obolibrary.org/obo/MP_0003563 abnormal pancreatic alpha cell physiology http://purl.obolibrary.org/obo/MP_0010147 abnormal endocrine pancreas physiology anomaly in the function of the glucagon-producing cells of the islets of Langerhans in the pancreas http://purl.obolibrary.org/obo/MP_0003564 abnormal insulin secretion http://purl.obolibrary.org/obo/MP_0003562 abnormal pancreatic beta cell physiology anomaly in the production or release of the hormone secreted by beta cells of the pancreas that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids http://purl.obolibrary.org/obo/MP_0003565 abnormal glucagon secretion http://purl.obolibrary.org/obo/MP_0003563 abnormal pancreatic alpha cell physiology anomaly in the production or release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes http://purl.obolibrary.org/obo/MP_0003566 abnormal cell adhesion http://purl.obolibrary.org/obo/MP_0005621 abnormal cell physiology altered ability of a cell to adhere to another cell or to a non-cellular component of the environment http://purl.obolibrary.org/obo/MP_0003567 abnormal fetal cardiomyocyte proliferation http://purl.obolibrary.org/obo/MP_0011390 abnormal fetal cardiomyocyte physiology anomaly in the ability of the differentiating cardiac muscle cell population to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0003568 uterus atresia http://purl.obolibrary.org/obo/MP_0001120 abnormal uterus morphology congenital absence of the normal opening or lumen of the uterus http://purl.obolibrary.org/obo/MP_0003569 increased leiomyoma incidence http://purl.obolibrary.org/obo/MP_0010290 increased muscle tumor incidence greater than the expected number of a benign tumor derived from smooth (nonstriated) muscle, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0003570 increased uterus leiomyoma incidence http://purl.obolibrary.org/obo/MP_0009222 increased uterus tumor incidence greater than the expected number of a benign tumor derived from smooth (nonstriated) muscle of the uterus, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0003571 uterus rupture http://purl.obolibrary.org/obo/MP_0001120 abnormal uterus morphology tearing of the uterine tissue; may be due to trauma or pregnancy complications http://purl.obolibrary.org/obo/MP_0003572 abnormal uterus development http://purl.obolibrary.org/obo/MP_0003936 abnormal reproductive system development abnormal morphogenesis of the female muscular organ of gestation http://purl.obolibrary.org/obo/MP_0003574 abnormal oviduct morphology http://purl.obolibrary.org/obo/MP_0009209 abnormal internal female genitalia morphology any structural anomaly of the tube through which the ova pass from the ovary to the uterus http://purl.obolibrary.org/obo/MP_0003575 absent oviduct http://purl.obolibrary.org/obo/MP_0003574 abnormal oviduct morphology absence of the tube through which the ova pass from the ovary to the uterus http://purl.obolibrary.org/obo/MP_0003576 oviduct hypoplasia http://purl.obolibrary.org/obo/MP_0009070 small oviduct underdevelopment or reduced size, usually due to a reduced number of cells, of the tube through which the ova pass from the ovary to the uterus http://purl.obolibrary.org/obo/MP_0003578 absent ovary http://purl.obolibrary.org/obo/MP_0005644 agonadal absence of the female reproductive gland containing the germ cells http://purl.obolibrary.org/obo/MP_0003579 increased ovarian carcinoma incidence http://purl.obolibrary.org/obo/MP_0008000 increased ovary tumor incidence greater than the expected number of a malignant neoplasm arising from ovarian tissue, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0003580 increased fibroma incidence http://purl.obolibrary.org/obo/MP_0010273 increased classified tumor incidence greater than the expected number of a benign tumor of fibrous or fully developed connective tissue, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0003581 increased ovarian fibroma incidence http://purl.obolibrary.org/obo/MP_0008000 increased ovary tumor incidence greater than the expected number of a benign tumor of fibrous or fully developed connective tissue in the ovary, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0003582 abnormal ovary development http://purl.obolibrary.org/obo/MP_0003936 abnormal reproductive system development abnormal morphogenesis of the ovarian follicle for the production of female germ cells or the endocrine cells for the production of estrogen and progesterone http://purl.obolibrary.org/obo/MP_0003584 bifid ureter http://purl.obolibrary.org/obo/MP_0000534 abnormal ureter morphology two ureters join before draining into the urinary bladder; a duplex kidney with a bifid renal pelvis or bifid ureter ensues when a single ureteral bud bifurcates before the ampulla bifurcates http://purl.obolibrary.org/obo/MP_0003585 large ureter http://purl.obolibrary.org/obo/MP_0000534 abnormal ureter morphology increased size or length of the tube that conducts the urine from the renal pelvis to the bladder http://purl.obolibrary.org/obo/MP_0003586 dilated ureter http://purl.obolibrary.org/obo/MP_0000534 abnormal ureter morphology abnormal distention of the ureter due to accumulation of fluid http://purl.obolibrary.org/obo/MP_0003587 ureter obstruction http://purl.obolibrary.org/obo/MP_0000534 abnormal ureter morphology a partial or total blockage in any part of the ureter causing obstruction of urine flow from the kidney to the urinary bladder; may be congenital, acquired, unilateral, bilateral, acute or chronic http://purl.obolibrary.org/obo/MP_0003588 ureter stenosis http://purl.obolibrary.org/obo/MP_0000534 abnormal ureter morphology abnormal narrowing or constriction of the ureter http://purl.obolibrary.org/obo/MP_0003589 abnormal ureter physiology http://purl.obolibrary.org/obo/MP_0005502 abnormal renal/urinary system physiology any functional anomaly of the tube that conducts the urine from the renal pelvis to the bladder http://purl.obolibrary.org/obo/MP_0003590 ureteral reflux http://purl.obolibrary.org/obo/MP_0003589 abnormal ureter physiology retrograde movement of urine from the bladder to the kidney http://purl.obolibrary.org/obo/MP_0003591 urethra atresia http://purl.obolibrary.org/obo/MP_0000537 abnormal urethra morphology closure, or failure to develop a connection in the canal that leads from the bladder and discharges urine externally http://purl.obolibrary.org/obo/MP_0003592 urethra stricture http://purl.obolibrary.org/obo/MP_0000537 abnormal urethra morphology abnormal narrowing at one or more points in the urethra, almost invariably restricted to males and often secondary to injury, inflammation, tumors or any other cause of scarring; whether congenital or acquired, urethral strictures may compromise voiding and cause incontinence, bleeding, stones or even renal failure http://purl.obolibrary.org/obo/MP_0003593 urethrovaginal fistula http://purl.obolibrary.org/obo/MP_0001139 abnormal vagina morphology an abnormal anatomical passage connecting the urethra and the vagina http://purl.obolibrary.org/obo/MP_0003594 small urethra http://purl.obolibrary.org/obo/MP_0000537 abnormal urethra morphology decreased size or length of the canal that leads from the bladder and discharges urine externally http://purl.obolibrary.org/obo/MP_0003595 epididymal cyst http://purl.obolibrary.org/obo/MP_0002631 abnormal epididymis morphology benign growths present in the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens http://purl.obolibrary.org/obo/MP_0003596 epididymal inflammation http://purl.obolibrary.org/obo/MP_0002254 reproductive system inflammation local accumulation of fluid, plasma proteins, and leukocytes in the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens http://purl.obolibrary.org/obo/MP_0003597 increased epididymal cystadenoma incidence http://purl.obolibrary.org/obo/MP_0010383 increased adenoma incidence greater than the expected number of a benign epithelial neoplasm with a glandular organization and a cyst-like appearance arising from epididymal tissue, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0003598 epispadia http://purl.obolibrary.org/obo/MP_0011796 abnormal external urethral orifice morphology congenital absence of the upper wall of the urethra, occurring in both sexes, but more often in the male, with the urethral opening somewhere on the dorsum of the penis at any point below the internal sphincter; in females, the malformed urethral opening is often located between the clitoris and the labia, or in the abdomen http://purl.obolibrary.org/obo/MP_0003599 large penis http://purl.obolibrary.org/obo/MP_0005187 abnormal penis morphology enlarged size of the organ of copulation and urination in the male http://purl.obolibrary.org/obo/MP_0003600 ectopic kidney http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology a kidney located outside of its normal position usually due to failed migration of the ureteral bud and developing metanephric blastema to the renal fossa; the most common example of renal ectopia is a pelvic kidney; other sites of ectopic kidneys include the iliac region, the abdomen, the chest, and, in some cases, the contralateral side, referred to as crossed http://purl.obolibrary.org/obo/MP_0003601 bifid kidney http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology cleft of the kidney into two parts or branches, often having the appearance of two lobes http://purl.obolibrary.org/obo/MP_0003602 increased renal hamartoma incidence http://purl.obolibrary.org/obo/MP_0010306 increased hamartoma incidence greater than the expected number of a benign formation of a mass of tissue of disproportionate size and distribution in the kidney, occurring in a specific population in a given time period; hamartomas are typically composed of an overgrowth of mature cells and tissues that normally occur in this tissue http://purl.obolibrary.org/obo/MP_0003603 increased renal hemangioblastoma incidence http://purl.obolibrary.org/obo/MP_0010294 increased kidney tumor incidence greater than the expected number of a benign cyst-like tumor of the kidney that is composed of multiple capillary and sinusoidal channels lined with endothelial cells, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0003604 single kidney http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology presence of only one of the paired organs responsible for urine secretion http://purl.obolibrary.org/obo/MP_0003605 fused kidneys http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology a defect in which there is a single malformed organ resulting from partial or complete fusion of the two renal anlage http://purl.obolibrary.org/obo/MP_0003606 kidney failure http://purl.obolibrary.org/obo/MP_0002136 abnormal kidney physiology failure of the kidneys to adequately filter toxins and waste products from the blood; classified as acute (as in acute kidney injury) or chronic (as in chronic kidney disease); a number of other diseases or health problems may cause either form of renal failure to occur http://purl.obolibrary.org/obo/MP_0003607 abnormal prostate gland physiology http://purl.obolibrary.org/obo/MP_0013327 abnormal male reproductive gland physiology any functional anomaly of the gland in males that secretes part of the seminiferous fluid http://purl.obolibrary.org/obo/MP_0003608 prostate gland inflammation http://purl.obolibrary.org/obo/MP_0003607 abnormal prostate gland physiology local accumulation of fluid, plasma proteins, and leukocytes in the prostate http://purl.obolibrary.org/obo/MP_0003609 small scrotum http://purl.obolibrary.org/obo/MP_0002669 abnormal scrotum morphology reduced size of the external sac of skin that encloses the testes http://purl.obolibrary.org/obo/MP_0003610 scrotum hyperplasia http://purl.obolibrary.org/obo/MP_0001150 enlarged scrotum overdevelopment or increase in size, usually due to an increase in cell number, of the external sac of skin that encloses the testes http://purl.obolibrary.org/obo/MP_0003611 scrotum hypoplasia http://purl.obolibrary.org/obo/MP_0003609 small scrotum underdevelopment or reduced size, usually due to a reduced number of cells, of the external sac of skin that encloses the testes http://purl.obolibrary.org/obo/MP_0003612 bifid scrotum http://purl.obolibrary.org/obo/MP_0002669 abnormal scrotum morphology cleft of the scrotum into two parts or branches, often having the appearance of two lobes http://purl.obolibrary.org/obo/MP_0003613 abnormal kidney medulla development http://purl.obolibrary.org/obo/MP_0003014 abnormal kidney medulla morphology anomaly in the differentiation of the inner portion of the kidney consisting of the renal pyramids http://purl.obolibrary.org/obo/MP_0003614 urinary bladder prolapse http://purl.obolibrary.org/obo/MP_0000538 abnormal urinary bladder morphology hernial protrusion of the urinary bladder, usually through the vaginal wall http://purl.obolibrary.org/obo/MP_0003615 urinary bladder diverticulum http://purl.obolibrary.org/obo/MP_0000538 abnormal urinary bladder morphology a pouch or sac protruding from the urinary bladder wall http://purl.obolibrary.org/obo/MP_0003616 abnormal urachus morphology http://purl.obolibrary.org/obo/MP_0001725 abnormal umbilical cord morphology any structural anomaly of the fibrous remnant of the allantoic stalk, a narrow fetal canal connecting the apex of the urinary bladder with the umbilicus located in the space of Retzius, between the transversalis fascia anteriorly and the peritoneum posteriorly. its lumen is normally obliterated during development, transforming the urachus into a solid cord, a functionless remnant that persists throughout life as the median umbilical ligament; failure of complete lumen obliteration may result in distinct congenital urachal remnant anomalies http://purl.obolibrary.org/obo/MP_0003617 urinary bladder hypoplasia http://purl.obolibrary.org/obo/MP_0000538 abnormal urinary bladder morphology underdevelopment or reduced size of the urinary bladder, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0003618 uterine cervical atresia http://purl.obolibrary.org/obo/MP_0001135 abnormal uterine cervix morphology narrowing of the cervical opening http://purl.obolibrary.org/obo/MP_0003619 abnormal urine color http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis any alteration from the usual straw-coloration of the urine http://purl.obolibrary.org/obo/MP_0003620 oliguria http://purl.obolibrary.org/obo/MP_0001756 abnormal urination decreased volume of urine produced and excreted http://purl.obolibrary.org/obo/MP_0003621 dysuria http://purl.obolibrary.org/obo/MP_0001756 abnormal urination difficult or painful urination http://purl.obolibrary.org/obo/MP_0003622 ischuria http://purl.obolibrary.org/obo/MP_0001756 abnormal urination upon urination, some urine is retained in the bladder instead of being excreted http://purl.obolibrary.org/obo/MP_0003623 hydrocele http://purl.obolibrary.org/obo/MP_0001146 abnormal testis morphology accumulation of fluid around testes http://purl.obolibrary.org/obo/MP_0003624 anuria http://purl.obolibrary.org/obo/MP_0001756 abnormal urination inability to form or excrete urine http://purl.obolibrary.org/obo/MP_0003625 kidney medulla hyperplasia http://purl.obolibrary.org/obo/MP_0003014 abnormal kidney medulla morphology overdevelopment or increased size, usually due an increased number of cells of the inner portion of the kidney consisting of the renal pyramids http://purl.obolibrary.org/obo/MP_0003626 kidney medulla hypoplasia http://purl.obolibrary.org/obo/MP_0003014 abnormal kidney medulla morphology underdevelopment or reduced size, usually due to a reduced number of cells, of the inner portion of the kidney consisting of the renal pyramids http://purl.obolibrary.org/obo/MP_0003627 abnormal leukocyte tethering or rolling http://purl.obolibrary.org/obo/MP_0009858 abnormal cellular extravasation anomaly in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation http://purl.obolibrary.org/obo/MP_0003628 abnormal leukocyte adhesion http://purl.obolibrary.org/obo/MP_0003156 abnormal leukocyte migration anomaly in the number of or process by which leukocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel http://purl.obolibrary.org/obo/MP_0003630 abnormal urothelium morphology http://purl.obolibrary.org/obo/MP_0000516 abnormal renal/urinary system morphology any structural anomaly of the epithelial lining of the lumen of the organs of the urinary tract http://purl.obolibrary.org/obo/MP_0003631 nervous system phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype the observable morphological and physiological characteristics of the extensive, intricate network of electochemical structures in the body that is comprised of the brain, spinal cord, nerves, ganglia and parts of the receptor organs that are manifested through development and lifespan http://purl.obolibrary.org/obo/MP_0003632 abnormal nervous system morphology http://purl.obolibrary.org/obo/MP_0003631 nervous system phenotype any structural anomaly of the extensive, intricate network of electochemical structures in the body that is comprised of the brain, spinal cord, nerves, ganglia and parts of the receptor organs that receive and interpret stimuli and transmit impulses to effector organs to control body functions http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology http://purl.obolibrary.org/obo/MP_0003631 nervous system phenotype any functional anomaly of the extensive, intricate network of electochemical structures in the body that is comprised of the brain, spinal cord, nerves, ganglia and parts of the receptor organs that receive and interpret stimuli and transmit impulses to effector organs to control body functions http://purl.obolibrary.org/obo/MP_0003634 abnormal glial cell morphology http://purl.obolibrary.org/obo/MP_0003632 abnormal nervous system morphology any structural anomaly of non-neuronal cells of the nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons http://purl.obolibrary.org/obo/MP_0003635 abnormal synaptic transmission http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology defect in the communication from a neuron to a target across a synapse http://purl.obolibrary.org/obo/MP_0003637 cochlear ganglion hypoplasia http://purl.obolibrary.org/obo/MP_0003986 small cochlear ganglion underdevelopment or reduced size, usually due to a reduced number of cells, of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve) http://purl.obolibrary.org/obo/MP_0003638 abnormal response/metabolism to endogenous compounds http://purl.obolibrary.org/obo/MP_0005266 abnormal metabolism altered ability or inability to metabolize or respond to substances normally present in the body http://purl.obolibrary.org/obo/MP_0003639 abnormal response to vitamins http://purl.obolibrary.org/obo/MP_0004019 abnormal vitamin homeostasis altered ability or inability to respond to or metabolize a group of organic substances that are required in trace amounts for the normal metabolic homeostasis of the body http://purl.obolibrary.org/obo/MP_0003641 small lung http://purl.obolibrary.org/obo/MP_0004881 abnormal lung size reduced size of the lung compared to controls http://purl.obolibrary.org/obo/MP_0003642 absent seminal vesicle http://purl.obolibrary.org/obo/MP_0002059 abnormal seminal vesicle morphology absence of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens http://purl.obolibrary.org/obo/MP_0003643 spleen atrophy http://purl.obolibrary.org/obo/MP_0000692 small spleen acquired diminution of the size of the spleen associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0003644 thymus atrophy http://purl.obolibrary.org/obo/MP_0000706 small thymus acquired diminution of the size of the thymus associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0003645 increased pancreatic beta cell number http://purl.obolibrary.org/obo/MP_0005217 abnormal pancreatic beta cell morphology greater than normal number of the cells of the pancreas that secrete insulin http://purl.obolibrary.org/obo/MP_0003646 muscle fatigue http://purl.obolibrary.org/obo/MP_0002106 abnormal muscle physiology increased muscle exhaustion or increased susceptibility to muscle exhaustion http://purl.obolibrary.org/obo/MP_0003647 absent oligodendrocytes http://purl.obolibrary.org/obo/MP_0009808 decreased oligodendrocyte number absence of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS http://purl.obolibrary.org/obo/MP_0003648 abnormal radial glial cell morphology http://purl.obolibrary.org/obo/MP_0009937 abnormal neuron differentiation any structural anomaly of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult http://purl.obolibrary.org/obo/MP_0003649 decreased heart right ventricle size http://purl.obolibrary.org/obo/MP_0010577 abnormal heart right ventricle size less than average size of the right ventricle compared to the average for a particular population http://purl.obolibrary.org/obo/MP_0003651 abnormal axon extension http://purl.obolibrary.org/obo/MP_0009937 abnormal neuron differentiation abnormality in the ability of an axon to exhibit long distance growth of a single axon process from a neuron cell body involved in cellular development http://purl.obolibrary.org/obo/MP_0003652 abnormal skin turgor http://purl.obolibrary.org/obo/MP_0001191 abnormal skin condition anomaly in the ability of the skin to resist deformation; influential factors include dehydration and age http://purl.obolibrary.org/obo/MP_0003653 decreased skin turgor http://purl.obolibrary.org/obo/MP_0003652 abnormal skin turgor reduced ability of the skin to resist deformation; influential factors include dehydration and age http://purl.obolibrary.org/obo/MP_0003654 nasal bone hyperplasia http://purl.obolibrary.org/obo/MP_0004474 enlarged nasal bone overdevelopment or increased size, usually due an increased number of cells in the bone which forms the nasal bridge http://purl.obolibrary.org/obo/MP_0003655 absent pancreas http://purl.obolibrary.org/obo/MP_0001944 abnormal pancreas morphology absence of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream http://purl.obolibrary.org/obo/MP_0003656 abnormal erythrocyte physiology http://purl.obolibrary.org/obo/MP_0012382 abnormal blood cell physiology aberrant measurable or observable characteristic related to the function of or processes in the cells in the blood that carry oxygen, red blood cells http://purl.obolibrary.org/obo/MP_0003657 abnormal erythrocyte osmotic lysis http://purl.obolibrary.org/obo/MP_0010163 hemolysis increase or decrease in the ability of RBCs to withstand changes in osmolarity http://purl.obolibrary.org/obo/MP_0003658 abnormal capillary morphology http://purl.obolibrary.org/obo/MP_0001614 abnormal blood vessel morphology any structural anomaly of the small branching blood vessels that form a network between the arterioles and venules, where the exchange of water, oxygen, carbon dioxide, and other nutrient and waste chemical substances occurs between the blood and the surrounding tissues http://purl.obolibrary.org/obo/MP_0003659 abnormal lymph circulation http://purl.obolibrary.org/obo/MP_0010368 abnormal lymphatic system physiology abnormalities in the flow of the lymph from the tissues into the veins of the circulatory system http://purl.obolibrary.org/obo/MP_0003660 chylothorax http://purl.obolibrary.org/obo/MP_0010334 pleural effusion an accumulation of chyle in the pleural space; chyle is fluid consisting of lymph and emulsified fats that is formed in the small intestine during digestion of fatty foods and taken up by the lymph vessels http://purl.obolibrary.org/obo/MP_0003661 abnormal locus ceruleus morphology http://purl.obolibrary.org/obo/MP_0000848 abnormal pons morphology any structural anomaly of a dense cluster of neurons within the dorsorostral pons; it is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic http://purl.obolibrary.org/obo/MP_0003662 abnormal long bone epiphyseal plate proliferative zone http://purl.obolibrary.org/obo/MP_0003055 abnormal long bone epiphyseal plate morphology any anomaly of the germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix http://purl.obolibrary.org/obo/MP_0003663 abnormal thermosensation http://purl.obolibrary.org/obo/MP_0002067 abnormal sensory capabilities/reflexes/nociception defect in the ability to sense or display a preference for a given temperature http://purl.obolibrary.org/obo/MP_0003664 ocular pterygium http://purl.obolibrary.org/obo/MP_0001310 abnormal conjunctiva morphology abnormal mass of hypertrophied bulbar subconjunctival tissue arising from the conjunctiva of the inner corner of the eye that obstructs vision by growing over the cornea towards the pupil http://purl.obolibrary.org/obo/MP_0003665 endophthalmitis http://purl.obolibrary.org/obo/MP_0001851 eye inflammation inflammation of the internal structures of the tissues in the eyeball http://purl.obolibrary.org/obo/MP_0003666 impaired sperm capacitation http://purl.obolibrary.org/obo/MP_0013286 abnormal sperm capacitation reduced ability or inability to undergo the changes in spermatozoa in the female genital tract that enables them to penetrate and fertilize an egg http://purl.obolibrary.org/obo/MP_0003667 increased hemangiosarcoma incidence http://purl.obolibrary.org/obo/MP_0010291 increased cardiovascular system tumor incidence higher than normal incidence of a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding http://purl.obolibrary.org/obo/MP_0003668 abnormal periodontal ligament morphology http://purl.obolibrary.org/obo/MP_0005504 abnormal ligament morphology any structural anomaly of the fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone; normally extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket http://purl.obolibrary.org/obo/MP_0003669 periodontal ligament hypercellularity http://purl.obolibrary.org/obo/MP_0003668 abnormal periodontal ligament morphology increased cell density of the periodontal ligament http://purl.obolibrary.org/obo/MP_0003670 dilated renal glomerular capsule http://purl.obolibrary.org/obo/MP_0002828 abnormal renal glomerular capsule morphology stretched or widened aperture of the expanded beginning of a nephron that contains the glomerulus http://purl.obolibrary.org/obo/MP_0003671 abnormal eyelid aperture http://purl.obolibrary.org/obo/MP_0001340 abnormal eyelid morphology any anomaly in the normal distance from one eyelid to the other, or closure of the eyes http://purl.obolibrary.org/obo/MP_0003672 abnormal ureter development http://purl.obolibrary.org/obo/MP_0003942 abnormal urinary system development any anomaly in the differentiation of the tube that conducts the urine from the renal pelvis to the bladder http://purl.obolibrary.org/obo/MP_0003673 abnormal inguinal canal morphology http://purl.obolibrary.org/obo/MP_0002160 abnormal reproductive system morphology any structural anomaly of the passage in the lower abdominal wall through which the spermatic cord in the male or the round ligament in the female, nerves and vessels pass from the pelvic cavity to the scrotum or labia majora, respectively http://purl.obolibrary.org/obo/MP_0003674 oxidative stress http://purl.obolibrary.org/obo/MP_0003186 abnormal redox activity condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma http://purl.obolibrary.org/obo/MP_0003675 kidney cysts http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion http://purl.obolibrary.org/obo/MP_0003677 abnormal ear lobe morphology http://purl.obolibrary.org/obo/MP_0002177 abnormal outer ear morphology any structural anomaly in the soft tissue at the base of the outer ear; consists of fat and fibrous tissue not reinforced by the auricular cartilage http://purl.obolibrary.org/obo/MP_0003678 absent ear lobes http://purl.obolibrary.org/obo/MP_0003677 abnormal ear lobe morphology missing the soft tissue at the base of the outer ear; consists of fat and fibrous tissue not reinforced by the auricular cartilage http://purl.obolibrary.org/obo/MP_0003679 ear lobe hypoplasia http://purl.obolibrary.org/obo/MP_0003677 abnormal ear lobe morphology underdevelopment or reduced size, usually due to a reduced number of cells, in the ear lobes http://purl.obolibrary.org/obo/MP_0003680 thick ear lobes http://purl.obolibrary.org/obo/MP_0003677 abnormal ear lobe morphology an increase in the fleshiness of the ear lobes http://purl.obolibrary.org/obo/MP_0003681 protruding ear lobes http://purl.obolibrary.org/obo/MP_0003677 abnormal ear lobe morphology ear lobes that project outward http://purl.obolibrary.org/obo/MP_0003682 linear crease in ear lobe http://purl.obolibrary.org/obo/MP_0003677 abnormal ear lobe morphology appearance of fold-like marks in the ear lobe http://purl.obolibrary.org/obo/MP_0003683 prominent ear lobes http://purl.obolibrary.org/obo/MP_0003681 protruding ear lobes conspicuous appearance of the ear lobes http://purl.obolibrary.org/obo/MP_0003684 abnormal inferior olivary complex morphology http://purl.obolibrary.org/obo/MP_0000846 abnormal medulla oblongata morphology any structural anomaly in the capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids; neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex and have been implicated in various functions, such as learning and timing of movements http://purl.obolibrary.org/obo/MP_0003685 abnormal cardiac ganglion morphology http://purl.obolibrary.org/obo/MP_0001034 abnormal parasympathetic ganglion morphology any structural anomaly of the parasympathetic ganglia of the cardiac plexus between the arch of the aorta and the bifurcation of the pulmonary artery http://purl.obolibrary.org/obo/MP_0003686 abnormal eye muscle morphology http://purl.obolibrary.org/obo/MP_0002108 abnormal muscle morphology any structural anomaly of the muscles of the eye http://purl.obolibrary.org/obo/MP_0003687 abnormal intraocular muscle morphology http://purl.obolibrary.org/obo/MP_0003686 abnormal eye muscle morphology any structural anomaly of the smooth muscles within the eye http://purl.obolibrary.org/obo/MP_0003688 ophthalmoparesis http://purl.obolibrary.org/obo/MP_0001389 abnormal eye movement loss of strength in the muscles that control eye movement http://purl.obolibrary.org/obo/MP_0003689 ophthalmoplegia http://purl.obolibrary.org/obo/MP_0002106 abnormal muscle physiology paralysis of the ocular muscles http://purl.obolibrary.org/obo/MP_0003690 abnormal glial cell physiology http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology any functional anomaly of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons http://purl.obolibrary.org/obo/MP_0003691 abnormal microglial cell physiology http://purl.obolibrary.org/obo/MP_0003690 abnormal glial cell physiology any functional anomaly of the small, migratory, phagocytic, interstitial cells derived from myeloid progenitor cells and found in the parenchyma of the central nervous system; microglia are scavengers, engulfing dead cells and other debris, and in Alzheimer's disease, microglia are found associated with dying nerve cells and amyloid plaques http://purl.obolibrary.org/obo/MP_0003692 xanthoma http://purl.obolibrary.org/obo/MP_0002118 abnormal lipid homeostasis a deposit of cholesterol rich material in a tissue, most often in the skin but also seen in tendons and in the brain http://purl.obolibrary.org/obo/MP_0003693 abnormal blastocyst hatching http://purl.obolibrary.org/obo/MP_0009781 abnormal preimplantation embryo development any anomaly of the hatching of the cellular blastocyst from the zona pellucida, the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation http://purl.obolibrary.org/obo/MP_0003694 failure of blastocyst to hatch from the zona pellucida http://purl.obolibrary.org/obo/MP_0003693 abnormal blastocyst hatching the hatching of the cellular blastocyst from the zona pellucida, the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, fails to occur http://purl.obolibrary.org/obo/MP_0003695 delayed blastocyst hatching from the zona pellucida http://purl.obolibrary.org/obo/MP_0003693 abnormal blastocyst hatching the hatching of the cellular blastocyst from the zona pellucida, the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, occurs later in development than expected http://purl.obolibrary.org/obo/MP_0003696 abnormal zona pellucida morphology http://purl.obolibrary.org/obo/MP_0001125 abnormal oocyte morphology any structural anomaly of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation http://purl.obolibrary.org/obo/MP_0003697 absent zona pellucida http://purl.obolibrary.org/obo/MP_0003696 abnormal zona pellucida morphology missing the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation http://purl.obolibrary.org/obo/MP_0003698 abnormal male reproductive system physiology http://purl.obolibrary.org/obo/MP_0001919 abnormal reproductive system physiology any functional anomaly of the male organs associated with producing offspring http://purl.obolibrary.org/obo/MP_0003699 abnormal female reproductive system physiology http://purl.obolibrary.org/obo/MP_0001919 abnormal reproductive system physiology any functional anomaly of the female organs associated with producing offspring http://purl.obolibrary.org/obo/MP_0003700 abnormal oviduct transport http://purl.obolibrary.org/obo/MP_0012018 abnormal oviduct physiology increased or decreased rate of passage of embryos or oocytes from the ovary to the uterus http://purl.obolibrary.org/obo/MP_0003701 elevated level of mitotic sister chromatid exchange http://purl.obolibrary.org/obo/MP_0004046 abnormal mitosis increased number of crossovers between sister chromatids during mitosis resulting in increased numbers of reciprocal exchanges of DNA between the two chromosomes; normally crossover exchanges are supressed during mitosis and only occur in meiosis http://purl.obolibrary.org/obo/MP_0003702 abnormal chromosome morphology http://purl.obolibrary.org/obo/MP_0003111 abnormal cell nucleus morphology any structural anomaly of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information http://purl.obolibrary.org/obo/MP_0003703 abnormal vestibulocochlear ganglion morphology http://purl.obolibrary.org/obo/MP_0003861 abnormal nervous system development any structural anomaly of the group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia http://purl.obolibrary.org/obo/MP_0003704 abnormal hair follicle development http://purl.obolibrary.org/obo/MP_0000377 abnormal hair follicle morphology any anomaly in the development of the epidermis from which the hair shaft develops http://purl.obolibrary.org/obo/MP_0003705 abnormal hypodermis morphology http://purl.obolibrary.org/obo/MP_0010678 abnormal skin adnexa morphology any structural anomaly of the irregular layer of loose connective tissue containing fibroblasts, adipose cells, and macrophages, that is immediately deep to the skin and superficial to the deep fascia; usually consisting primarily of a fatty layer and may also include a muscle layer and/or a fibrous layer, or it may occur as a membranous layer only, being nearly devoid of fat; it contains skin ligaments extending between the dermis and deep fascia, cutaneous nerves, and superficial vessels, with terminal branches passing into the skin layers http://purl.obolibrary.org/obo/MP_0003706 abnormal cell nucleus count http://purl.obolibrary.org/obo/MP_0003111 abnormal cell nucleus morphology absent or greater than one nuclei present per cell body when one is expected; often due to failed cytokinesis or events leading to apoptosis http://purl.obolibrary.org/obo/MP_0003707 increased cell nucleus count http://purl.obolibrary.org/obo/MP_0003706 abnormal cell nucleus count greater than one nuclei present per cell body when one is expected; often due to failed cytokinesis http://purl.obolibrary.org/obo/MP_0003708 binucleate http://purl.obolibrary.org/obo/MP_0003707 increased cell nucleus count two nuclei present per cell body when one is expected; often due to failed cytokinesis http://purl.obolibrary.org/obo/MP_0003709 anucleate http://purl.obolibrary.org/obo/MP_0003706 abnormal cell nucleus count absent nucleus of a cell body when one is expected; often due to events leading to apoptosis http://purl.obolibrary.org/obo/MP_0003710 abnormal physiological neovascularization http://purl.obolibrary.org/obo/MP_0000260 abnormal angiogenesis anomalies in the development of new blood vessels in restoration of blood circulation during the healing process http://purl.obolibrary.org/obo/MP_0003711 pathological neovascularization http://purl.obolibrary.org/obo/MP_0000249 abnormal blood vessel physiology the proliferation of blood vessels in abnormal tissues or in abnormal positions http://purl.obolibrary.org/obo/MP_0003712 raised ear position http://purl.obolibrary.org/obo/MP_0000023 abnormal ear distance/ position outer ears which are situated above the normal location http://purl.obolibrary.org/obo/MP_0003713 abnormal ear rotation http://purl.obolibrary.org/obo/MP_0000023 abnormal ear distance/ position outer ears that are positioned such that the ears are turned relative to the anterior-posterior body axis, but the ears emerge from the head at the usual position http://purl.obolibrary.org/obo/MP_0003714 absent platelets http://purl.obolibrary.org/obo/MP_0003179 decreased platelet cell number lack of non-nucleated cells found in the blood and involved in blood coagulation http://purl.obolibrary.org/obo/MP_0003715 posteriorly rotated ears http://purl.obolibrary.org/obo/MP_0003713 abnormal ear rotation outer ears that are positioned such that the ears are turned backwards relative to the anterior-posterior body axis, but the ears emerge from the head at the usual position http://purl.obolibrary.org/obo/MP_0003716 anteriorly rotated ears http://purl.obolibrary.org/obo/MP_0003713 abnormal ear rotation outer ears that are positioned such that the ears are turned forward relative to the anterior-posterior body axis, but the ears emerge from the head at the usual position http://purl.obolibrary.org/obo/MP_0003717 pallor http://purl.obolibrary.org/obo/MP_0009931 abnormal skin appearance an unnatural paleness to the skin, generally attributable to anemia http://purl.obolibrary.org/obo/MP_0003718 maternal effect http://purl.obolibrary.org/obo/MP_0005395 other phenotype expression of a phenotypic trait in a female animal's offspring that is dependent on the maternal genotype http://purl.obolibrary.org/obo/MP_0003719 abnormal pericyte morphology http://purl.obolibrary.org/obo/MP_0001614 abnormal blood vessel morphology any structural anomaly of the connective tissue cells that occurs around capillaries or other small blood vessels http://purl.obolibrary.org/obo/MP_0003720 abnormal neural tube closure http://purl.obolibrary.org/obo/MP_0002151 abnormal neural tube morphology/development any anomaly in the last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline http://purl.obolibrary.org/obo/MP_0003721 increased tumor growth/size http://purl.obolibrary.org/obo/MP_0003448 altered tumor morphology greater than expected development of tumorous growth when compared to controls http://purl.obolibrary.org/obo/MP_0003722 absent ureter http://purl.obolibrary.org/obo/MP_0000534 abnormal ureter morphology missing the tube that conducts the urine from the renal pelvis to the bladder http://purl.obolibrary.org/obo/MP_0003723 abnormal long bone morphology http://purl.obolibrary.org/obo/MP_0009250 abnormal appendicular skeleton morphology any structural anomaly of the bones that consist of a tubular shaft (diaphysis) and two ends that are wider than the shaft (epiphysis); long bones include the femora, tibiae, and fibulae, and the humeri, radii, and ulnae of the limbs; metacarpals and metatarsals of the autopods, the phalanges of the digits, and the clavicles http://purl.obolibrary.org/obo/MP_0003724 increased susceptibility to induced arthritis http://purl.obolibrary.org/obo/MP_0005350 increased susceptibility to autoimmune disorder more likely to be stricken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents http://purl.obolibrary.org/obo/MP_0003725 increased autoantibody level http://purl.obolibrary.org/obo/MP_0001844 autoimmune response elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease http://purl.obolibrary.org/obo/MP_0003726 decreased autoantibody level http://purl.obolibrary.org/obo/MP_0001844 autoimmune response reduced level of antibodies to self-antigens present in the sera http://purl.obolibrary.org/obo/MP_0003727 abnormal retinal layer morphology http://purl.obolibrary.org/obo/MP_0001325 abnormal retina morphology any structural anomaly of any of the layers that make up the retina http://purl.obolibrary.org/obo/MP_0003728 abnormal retinal photoreceptor layer morphology http://purl.obolibrary.org/obo/MP_0006069 abnormal retinal neuronal layer morphology any structural anomaly of the photoreceptor layer http://purl.obolibrary.org/obo/MP_0003729 abnormal photoreceptor outer segment morphology http://purl.obolibrary.org/obo/MP_0001004 abnormal retinal photoreceptor morphology any structural anomaly of the photoreceptor region that is rich in the visual pigment rhodopsin http://purl.obolibrary.org/obo/MP_0003730 abnormal photoreceptor inner segment morphology http://purl.obolibrary.org/obo/MP_0001004 abnormal retinal photoreceptor morphology any structural anomaly of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region http://purl.obolibrary.org/obo/MP_0003731 abnormal retinal outer nuclear layer morphology http://purl.obolibrary.org/obo/MP_0006069 abnormal retinal neuronal layer morphology any structural anomaly of the retinal layer that contains the nuclei and cell bodies of rods and cones http://purl.obolibrary.org/obo/MP_0003732 abnormal retinal outer plexiform layer morphology http://purl.obolibrary.org/obo/MP_0006069 abnormal retinal neuronal layer morphology any structural anomaly of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites) http://purl.obolibrary.org/obo/MP_0003733 abnormal retinal inner nuclear layer morphology http://purl.obolibrary.org/obo/MP_0006069 abnormal retinal neuronal layer morphology any structural anomaly of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells http://purl.obolibrary.org/obo/MP_0003734 abnormal retinal inner plexiform layer morphology http://purl.obolibrary.org/obo/MP_0006069 abnormal retinal neuronal layer morphology any structural anomaly of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites http://purl.obolibrary.org/obo/MP_0003735 cup-shaped ears http://purl.obolibrary.org/obo/MP_0000022 abnormal ear shape deeply concave appearance to the outer ear http://purl.obolibrary.org/obo/MP_0003736 folded helix http://purl.obolibrary.org/obo/MP_0000022 abnormal ear shape the bending over of the upper cartilaginous rim of the outer ear http://purl.obolibrary.org/obo/MP_0003737 ossification of pinnae http://purl.obolibrary.org/obo/MP_0002177 abnormal outer ear morphology formation of bone in the outer ear, which is normally cartilaginous http://purl.obolibrary.org/obo/MP_0003739 dense middle ear ossicles http://purl.obolibrary.org/obo/MP_0005105 abnormal middle ear ossicle morphology thickening of the three small bones of the middle ear http://purl.obolibrary.org/obo/MP_0003740 fusion of middle ear ossicles http://purl.obolibrary.org/obo/MP_0005105 abnormal middle ear ossicle morphology union of the three small bones of the middle ear into a single structure http://purl.obolibrary.org/obo/MP_0003741 tinnitus http://purl.obolibrary.org/obo/MP_0001963 abnormal hearing physiology persistent sensation of buzzing, ringing, clicking, or other noises in the ear http://purl.obolibrary.org/obo/MP_0003742 narrow head http://purl.obolibrary.org/obo/MP_0011495 abnormal head shape a shorter ear- to -ear distance resulting in the appearance of a thin face and a protruding nasal region http://purl.obolibrary.org/obo/MP_0003743 abnormal facial morphology http://purl.obolibrary.org/obo/MP_0000432 abnormal head morphology any structural anomaly of the face http://purl.obolibrary.org/obo/MP_0003745 abnormal mucosal lining of the mouth http://purl.obolibrary.org/obo/MP_0000462 abnormal digestive system morphology any structural anomaly of the mucus -secreting tissue that lines the oral cavity http://purl.obolibrary.org/obo/MP_0003746 stomatitis http://purl.obolibrary.org/obo/MP_0001846 increased inflammatory response inflammation of the mucous lining of the mouth http://purl.obolibrary.org/obo/MP_0003747 mouth mucosal ulcer http://purl.obolibrary.org/obo/MP_0003745 abnormal mucosal lining of the mouth lesions through the mucous membrane of the mouth, usually associated with loss of tissue http://purl.obolibrary.org/obo/MP_0003748 increased oral mucosa hemangioma incidence http://purl.obolibrary.org/obo/MP_0003750 increased mouth tumor incidence greater than the expected number of a benign tumor characterized by blood-filled spaces lined by benign endothelial cells in the oral mucosa, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0003749 down-turned corners of mouth http://purl.obolibrary.org/obo/MP_0000452 abnormal mouth morphology the lateral points of the oral cavity opening appear in a lower position that the rest of the lips http://purl.obolibrary.org/obo/MP_0003750 increased mouth tumor incidence http://purl.obolibrary.org/obo/MP_0010292 increased alimentary system tumor incidence greater than the expected number of neoplasms in the mouth tissues, usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0003751 oral leukoplakia http://purl.obolibrary.org/obo/MP_0003745 abnormal mucosal lining of the mouth white patchy lesions of the mucous membranes of the oral cavity; often considered a precancerous condition http://purl.obolibrary.org/obo/MP_0003752 increased oral papilloma incidence http://purl.obolibrary.org/obo/MP_0003750 increased mouth tumor incidence greater than the expected number of benign tumors consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells in the oral cavity http://purl.obolibrary.org/obo/MP_0003753 increased lip papilloma incidence http://purl.obolibrary.org/obo/MP_0003780 increased lip tumor incidence greater than the expected number of a benign epithelial tumor of the lip of the oral cavity, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0003754 increased gingival papilloma incidence http://purl.obolibrary.org/obo/MP_0003752 increased oral papilloma incidence greater than the expected number of a benign epithelial tumor of the oral gum tissue http://purl.obolibrary.org/obo/MP_0003755 abnormal palate morphology http://purl.obolibrary.org/obo/MP_0000462 abnormal digestive system morphology any structural anomaly of the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) http://purl.obolibrary.org/obo/MP_0003756 abnormal hard palate morphology http://purl.obolibrary.org/obo/MP_0003755 abnormal palate morphology any structural anomaly of the anterior part of the palate that is supported by and includes the palatal extensions of the maxillary and palatine bones in the adult http://purl.obolibrary.org/obo/MP_0003757 high palate http://purl.obolibrary.org/obo/MP_0003755 abnormal palate morphology greater distance upward to the roof of the oral cavity than usual http://purl.obolibrary.org/obo/MP_0003758 narrow palate http://purl.obolibrary.org/obo/MP_0003755 abnormal palate morphology abnormally slim shape to the roof of the oral cavity http://purl.obolibrary.org/obo/MP_0003759 broad palate http://purl.obolibrary.org/obo/MP_0003755 abnormal palate morphology abnormally wide shape to the roof of the oral cavity http://purl.obolibrary.org/obo/MP_0003760 short palate http://purl.obolibrary.org/obo/MP_0003755 abnormal palate morphology abnormally decreased length to the roof of the oral cavity http://purl.obolibrary.org/obo/MP_0003761 arched palate http://purl.obolibrary.org/obo/MP_0003755 abnormal palate morphology abnormally concaved shape to the roof of the oral cavity http://purl.obolibrary.org/obo/MP_0003762 abnormal immune organ physiology http://purl.obolibrary.org/obo/MP_0001790 abnormal immune system physiology any functional anomaly of the organs of the immune system http://purl.obolibrary.org/obo/MP_0003763 abnormal thymus physiology http://purl.obolibrary.org/obo/MP_0003762 abnormal immune organ physiology any functional anomaly of the primary lymphoid organ that is required for immune system development http://purl.obolibrary.org/obo/MP_0003764 abnormal palatal depth http://purl.obolibrary.org/obo/MP_0003755 abnormal palate morphology any change in the average distance of the deepest point in the midline of the palate relative to the midline point on the anterior crest of the alveolar gum pad ridge http://purl.obolibrary.org/obo/MP_0003765 increased palatal depth http://purl.obolibrary.org/obo/MP_0003764 abnormal palatal depth greater than average distance of the deepest point in the midline of the palate relative to the midline point on the anterior crest of the alveolar gum pad ridge http://purl.obolibrary.org/obo/MP_0003766 decreased palatal depth http://purl.obolibrary.org/obo/MP_0003764 abnormal palatal depth reduction in the average distance of the deepest point in the midline of the palate relative to the midline point on the anterior crest of the alveolar gum pad ridge http://purl.obolibrary.org/obo/MP_0003767 palate inflammation http://purl.obolibrary.org/obo/MP_0001846 increased inflammatory response local accumulation of fluid, plasma proteins and leukocytes in the palate http://purl.obolibrary.org/obo/MP_0003768 palatal telangiectases http://purl.obolibrary.org/obo/MP_0004175 telangiectases vascular lesion formed by dilation of a group of small blood vessels in the palate http://purl.obolibrary.org/obo/MP_0003769 abnormal lip morphology http://purl.obolibrary.org/obo/MP_0000452 abnormal mouth morphology any structural anomaly of the fleshy margins of the mouth http://purl.obolibrary.org/obo/MP_0003770 lip ulcer http://purl.obolibrary.org/obo/MP_0003769 abnormal lip morphology lesions through the mucous membrane of the inner surface of the lip http://purl.obolibrary.org/obo/MP_0003771 abnormal lip shape http://purl.obolibrary.org/obo/MP_0003769 abnormal lip morphology changes in the characteristic contours of the fleshy margins of the mouth http://purl.obolibrary.org/obo/MP_0003772 lip pits http://purl.obolibrary.org/obo/MP_0003769 abnormal lip morphology an abnormal hollow or depression in the fleshy margins of the mouth http://purl.obolibrary.org/obo/MP_0003773 everted lip http://purl.obolibrary.org/obo/MP_0003769 abnormal lip morphology an outward turning of the inner surface of the lip http://purl.obolibrary.org/obo/MP_0003774 fleshy lip http://purl.obolibrary.org/obo/MP_0003769 abnormal lip morphology lips having an abundance and often an excess of soft tissue http://purl.obolibrary.org/obo/MP_0003775 thin lip http://purl.obolibrary.org/obo/MP_0003769 abnormal lip morphology lips having a reduced amount of soft tissue http://purl.obolibrary.org/obo/MP_0003776 lip atrophy http://purl.obolibrary.org/obo/MP_0003769 abnormal lip morphology acquired diminution of the size of the lip tissue associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0003777 lip inflammation http://purl.obolibrary.org/obo/MP_0001846 increased inflammatory response local accumulation of fluid, plasma proteins and leukocytes in the lips http://purl.obolibrary.org/obo/MP_0003778 lip telangiectases http://purl.obolibrary.org/obo/MP_0004175 telangiectases vascular lesion formed by dilation of a group of small blood vessels in the lip http://purl.obolibrary.org/obo/MP_0003779 lip cysts http://purl.obolibrary.org/obo/MP_0003769 abnormal lip morphology fluid-filled membranous sacs present in the lips http://purl.obolibrary.org/obo/MP_0003780 increased lip tumor incidence http://purl.obolibrary.org/obo/MP_0008018 increased facial tumor incidence greater than the expected number of abnormal rapidly proliferating cells in the lip, usually in the form of a distinct mass, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0003781 increased lip neuroma incidence http://purl.obolibrary.org/obo/MP_0010281 increased nervous system tumor incidence greater than the expected number of a tumor derived from nerve cells or fibers residing in the lip, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0003782 short lip http://purl.obolibrary.org/obo/MP_0003769 abnormal lip morphology lip that does not extend fully to the normal placement and meet the opposite lip http://purl.obolibrary.org/obo/MP_0003783 tented upper lip http://purl.obolibrary.org/obo/MP_0012523 abnormal upper lip morphology an upper lip having an inverted V- shape http://purl.obolibrary.org/obo/MP_0003784 thin lip vermillion border http://purl.obolibrary.org/obo/MP_0003769 abnormal lip morphology reduced thickness of the line between the lip and the facial skin around the mouth http://purl.obolibrary.org/obo/MP_0003785 lip mucosal nodules http://purl.obolibrary.org/obo/MP_0003769 abnormal lip morphology small mass of tissue or aggregation of cells in the mucosal tissue of the inner lip http://purl.obolibrary.org/obo/MP_0003786 premature aging http://purl.obolibrary.org/obo/MP_0010768 mortality/aging earlier than normal occurrence of the normal signs of aging http://purl.obolibrary.org/obo/MP_0003787 abnormal imprinting http://purl.obolibrary.org/obo/MP_0012167 abnormal epigenetic regulation of gene expression defects in the establishment of heritable alterations in the activity of a gene that depend on whether it passed through the paternal or the maternal germline, but that are not encoded by DNA itself http://purl.obolibrary.org/obo/MP_0003789 increased osteosarcoma incidence http://purl.obolibrary.org/obo/MP_0010280 increased skeletal tumor incidence greater than the expected number of a malignant neoplasm derived form mesenchymal stem cells, osteoblasts or osteocytes, occurring in a specific population in a given time period; osteosarcoma is a highly invasive and destructive tumor rising in the skeleton with osteoid and immature woven bone http://purl.obolibrary.org/obo/MP_0003790 absent CD4-positive, alpha beta T cells http://purl.obolibrary.org/obo/MP_0008075 decreased CD4-positive, alpha beta T cell number lack of the set of single-positive T cells that express CD4 on their surface http://purl.obolibrary.org/obo/MP_0003791 abnormal minor salivary gland morphology http://purl.obolibrary.org/obo/MP_0000613 abnormal salivary gland morphology any structural anomaly of the smaller, largely mucus-secreting, exocrine glands of the oral cavity, consisting of the labial, buccal, molar, lingual, and palatine glands http://purl.obolibrary.org/obo/MP_0003792 abnormal major salivary gland morphology http://purl.obolibrary.org/obo/MP_0000613 abnormal salivary gland morphology any structural anomaly of the three largest glands of the oral cavity that secrete most of the saliva, including the parotid, submandibular, and sublingual glands http://purl.obolibrary.org/obo/MP_0003793 abnormal submandibular gland morphology http://purl.obolibrary.org/obo/MP_0003792 abnormal major salivary gland morphology any structural anomaly of either of the large major salivary glands situated beneath the mandible http://purl.obolibrary.org/obo/MP_0003794 delayed somite formation http://purl.obolibrary.org/obo/MP_0001688 abnormal somite development late onset of the induction and/or differentiation of the somites http://purl.obolibrary.org/obo/MP_0003795 abnormal bone structure http://purl.obolibrary.org/obo/MP_0005508 abnormal skeleton morphology anomaly in the composite material or the layered arrangement of the bony endoskeleton of the body http://purl.obolibrary.org/obo/MP_0003797 abnormal compact bone morphology http://purl.obolibrary.org/obo/MP_0003795 abnormal bone structure any structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae http://purl.obolibrary.org/obo/MP_0003798 abnormal Harderian gland pigmentation http://purl.obolibrary.org/obo/MP_0009389 abnormal extracutaneous pigmentation any anomaly in the coloring of the sebaceous gland located behind the eyeball in the orbit that excretes fluid that facilitates movement of the third eyelid, due to changes in the amount, shape, or distribution of cells producing pigment http://purl.obolibrary.org/obo/MP_0003799 impaired macrophage chemotaxis http://purl.obolibrary.org/obo/MP_0010760 abnormal macrophage chemotaxis reduced diffusion or accumulation of macrophages in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions http://purl.obolibrary.org/obo/MP_0003800 monodactyly http://purl.obolibrary.org/obo/MP_0002110 abnormal digit morphology having only one toe or digit on each extremity http://purl.obolibrary.org/obo/MP_0003806 abnormal nucleotide metabolism http://purl.obolibrary.org/obo/MP_0005266 abnormal metabolism any anomaly in the chemical reactions and pathways involving a nucleotide, including metabolic, catabolic and biosynthetic processes http://purl.obolibrary.org/obo/MP_0003807 camptodactyly http://purl.obolibrary.org/obo/MP_0002110 abnormal digit morphology permanent flexion of one or more digits; contractures may also be seen in the wrists and at the elbows http://purl.obolibrary.org/obo/MP_0003808 increased atrioventricular cushion size http://purl.obolibrary.org/obo/MP_0000297 abnormal atrioventricular cushion morphology larger than normal mounds of embryonic connective tissue that bulge into the fetal atrioventricular canal http://purl.obolibrary.org/obo/MP_0003809 abnormal hair shaft morphology http://purl.obolibrary.org/obo/MP_0000367 abnormal coat/ hair morphology any structural anomaly of the cuticle, cortex and/or medulla of a hair http://purl.obolibrary.org/obo/MP_0003810 abnormal hair cuticle http://purl.obolibrary.org/obo/MP_0003809 abnormal hair shaft morphology anomalies in the thin, smooth and glossy outer protective cell layer of hair shaft http://purl.obolibrary.org/obo/MP_0003811 abnormal hair cortex morphology http://purl.obolibrary.org/obo/MP_0003809 abnormal hair shaft morphology any structural anomaly in the spindle shaped cells of the hair shaft that contains keratin fibrils and matrix http://purl.obolibrary.org/obo/MP_0003812 abnormal hair medulla http://purl.obolibrary.org/obo/MP_0003809 abnormal hair shaft morphology anomalies of hair medullary cell formation and arrangement of the innermost core of the hair shaft http://purl.obolibrary.org/obo/MP_0003813 abnormal hair follicle dermal papilla morphology http://purl.obolibrary.org/obo/MP_0010681 abnormal hair follicle bulb morphology any structural anomaly of the mesodermal signaling center of the hair follicle consisting of closely packed specialized mesenchymal fibroblasts http://purl.obolibrary.org/obo/MP_0003814 vascular smooth muscle cell hypoplasia http://purl.obolibrary.org/obo/MP_0005592 abnormal vascular smooth muscle morphology decreased numbers of smooth muscle cells in the vascular wall http://purl.obolibrary.org/obo/MP_0003815 hairless http://purl.obolibrary.org/obo/MP_0002073 abnormal hair growth having no hair at any time throughout lifespan, generally referring to primary genetic hairlessness http://purl.obolibrary.org/obo/MP_0003816 abnormal pituitary gland development http://purl.obolibrary.org/obo/MP_0000633 abnormal pituitary gland morphology malformation or incomplete differentiation of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin http://purl.obolibrary.org/obo/MP_0003817 abnormal pituitary diverticulum morphology http://purl.obolibrary.org/obo/MP_0013337 abnormal adenohypophysis development any structural anomaly of a tubular outgrowth of ectoderm from the stomodeum of the embryo; the outgrowth grows toward the infundibular process of the diencephalon, around which it forms a cup-like mass, giving rise to the pars distalis and pars juxtaneuralis of the hypophysis http://purl.obolibrary.org/obo/MP_0003818 abnormal eye muscle development http://purl.obolibrary.org/obo/MP_0001286 abnormal eye development malformation or arrest of differentiation of the muscles of the eye http://purl.obolibrary.org/obo/MP_0003819 increased left ventricle diastolic pressure http://purl.obolibrary.org/obo/MP_0010754 abnormal heart left ventricle pressure increase in the pressure in the left ventricle between heart beats when the heart is relaxed http://purl.obolibrary.org/obo/MP_0003820 increased left ventricle systolic pressure http://purl.obolibrary.org/obo/MP_0010754 abnormal heart left ventricle pressure increase in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries http://purl.obolibrary.org/obo/MP_0003821 decreased left ventricle diastolic pressure http://purl.obolibrary.org/obo/MP_0010754 abnormal heart left ventricle pressure decrease in the pressure in the left ventricle between heart beats when the heart is relaxed http://purl.obolibrary.org/obo/MP_0003822 decreased left ventricle systolic pressure http://purl.obolibrary.org/obo/MP_0010754 abnormal heart left ventricle pressure decrease in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries http://purl.obolibrary.org/obo/MP_0003823 increased left ventricle developed pressure http://purl.obolibrary.org/obo/MP_0010754 abnormal heart left ventricle pressure increase in the difference between left ventricular systolic and diastolic pressures http://purl.obolibrary.org/obo/MP_0003824 decreased left ventricle developed pressure http://purl.obolibrary.org/obo/MP_0010754 abnormal heart left ventricle pressure decrease in the difference between left ventricular systolic and diastolic pressures http://purl.obolibrary.org/obo/MP_0003825 abnormal pillar cell morphology http://purl.obolibrary.org/obo/MP_0004300 abnormal organ of Corti supporting cell morphology any structural anomaly of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti http://purl.obolibrary.org/obo/MP_0003826 abnormal Mullerian duct morphology http://purl.obolibrary.org/obo/MP_0008487 abnormal mesonephros morphology any structural anomaly of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina http://purl.obolibrary.org/obo/MP_0003827 abnormal Wolffian duct morphology http://purl.obolibrary.org/obo/MP_0008487 abnormal mesonephros morphology any structural anomaly of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and later develop into the ductus deferens in the male http://purl.obolibrary.org/obo/MP_0003828 pulmonary edema http://purl.obolibrary.org/obo/MP_0002133 abnormal respiratory system physiology an accumulation of an excessive amount of serous fluid in the parenchyma and the alveoli via effusion of intravascular fluid from the pulmonary vascular bed http://purl.obolibrary.org/obo/MP_0003829 impaired febrile response http://purl.obolibrary.org/obo/MP_0001777 abnormal body temperature homeostasis reduced or absent febrile response to exogenous or endogenous pyrogens http://purl.obolibrary.org/obo/MP_0003830 abnormal testis development http://purl.obolibrary.org/obo/MP_0003936 abnormal reproductive system development abnormal morphogenesis of the male reproductive gland containing the germ cells http://purl.obolibrary.org/obo/MP_0003833 decreased satellite cell number http://purl.obolibrary.org/obo/MP_0000759 abnormal skeletal muscle morphology less than the normal number of unfused cells in muscle that play a role in muscle regeneration http://purl.obolibrary.org/obo/MP_0003834 abnormal adrenergic chromaffin cell morphology http://purl.obolibrary.org/obo/MP_0008504 abnormal adrenal chromaffin cell morphology any structural anomaly of the neuroendocrine cells of the medulla of the adrenal gland that are innervated by the splanchnic nerve and that are responsible for epinephrine secretion http://purl.obolibrary.org/obo/MP_0003838 abnormal milk ejection http://purl.obolibrary.org/obo/MP_0001961 abnormal reflex impaired milk ejection reflex in response to suckling during lactation http://purl.obolibrary.org/obo/MP_0003839 abnormal insulin clearance http://purl.obolibrary.org/obo/MP_0002078 abnormal glucose homeostasis increase or decrease in the rate at which insulin is removed from the blood stream http://purl.obolibrary.org/obo/MP_0003840 abnormal coronal suture morphology http://purl.obolibrary.org/obo/MP_0002835 abnormal cranial suture morphology any structural anomaly of the dense, fibrous connective tissue joint between the parietal bones and the frontal bone http://purl.obolibrary.org/obo/MP_0003841 abnormal lambdoidal suture morphology http://purl.obolibrary.org/obo/MP_0002835 abnormal cranial suture morphology any structural anomaly of the dense, fibrous connective tissue joint between the parietal bones and the occipital bone http://purl.obolibrary.org/obo/MP_0003842 abnormal metopic suture morphology http://purl.obolibrary.org/obo/MP_0002835 abnormal cranial suture morphology any structural anomaly of the dense, fibrous connective tissue joint between the frontal bone from the sagittal suture to the root of the nose; it is visible in neonates and juveniles, but it is frequently obliterated in some adult organisms http://purl.obolibrary.org/obo/MP_0003843 abnormal sagittal suture morphology http://purl.obolibrary.org/obo/MP_0002835 abnormal cranial suture morphology any structural anomaly of the dense, fibrous connective tissue joint between the parietal bones http://purl.obolibrary.org/obo/MP_0003844 abnormal squamo-parietal suture morphology http://purl.obolibrary.org/obo/MP_0002835 abnormal cranial suture morphology any structural anomaly of the dense, fibrous connective tissue joint between the squamous portion of the temporal bones with the parietal bones http://purl.obolibrary.org/obo/MP_0003845 abnormal decidualization http://purl.obolibrary.org/obo/MP_0004014 abnormal uterine environment atypical cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation; this process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta; expected changes include the eosinophilic proliferation around arterioles after ovulation or progesterone action on endometrium which increases glandular epithelial secretion, stimulates glycogen accumulation in stromal cell cytoplasm, and promotes stromal vascularity (spiral arterioles) and edema http://purl.obolibrary.org/obo/MP_0003846 matted coat http://purl.obolibrary.org/obo/MP_0002074 abnormal hair texture coat hairs sticks together to form clumps and does not lie flat http://purl.obolibrary.org/obo/MP_0003847 disorganized lens bow http://purl.obolibrary.org/obo/MP_0001303 abnormal lens morphology derangement of the area where the lens epithelium pushes into the lens proper and forms new lens fibers http://purl.obolibrary.org/obo/MP_0003848 brittle hair http://purl.obolibrary.org/obo/MP_0002074 abnormal hair texture hair is susceptible to breakage http://purl.obolibrary.org/obo/MP_0003849 greasy coat http://purl.obolibrary.org/obo/MP_0001510 abnormal coat appearance fur is oily in appearance or texture http://purl.obolibrary.org/obo/MP_0003850 abnormal thymocyte activation http://purl.obolibrary.org/obo/MP_0003763 abnormal thymus physiology anomaly in the process of producing activated thymocytes from naive thymocytes http://purl.obolibrary.org/obo/MP_0003851 skeletal muscle interstitial fibrosis http://purl.obolibrary.org/obo/MP_0009419 skeletal muscle fibrosis formation of fibrous tissue within the interstices of skeletal muscle as a result of repair or a reactive process http://purl.obolibrary.org/obo/MP_0003852 skeletal muscle necrosis http://purl.obolibrary.org/obo/MP_0000759 abnormal skeletal muscle morphology morphological changes resulting from pathological death of skeletal muscle tissue; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0003853 dry skin http://purl.obolibrary.org/obo/MP_0009931 abnormal skin appearance skin characterized by the lack of natural or normal moisture http://purl.obolibrary.org/obo/MP_0003854 abnormal forelimb stylopod morphology http://purl.obolibrary.org/obo/MP_0000550 abnormal forelimb morphology any structural anomaly of the proximal element of the forelimb including the humerus http://purl.obolibrary.org/obo/MP_0003855 abnormal forelimb zeugopod morphology http://purl.obolibrary.org/obo/MP_0000550 abnormal forelimb morphology any structural anomaly of the distal elements of the forelimb including the radius and ulna http://purl.obolibrary.org/obo/MP_0003856 abnormal hindlimb stylopod morphology http://purl.obolibrary.org/obo/MP_0000556 abnormal hindlimb morphology any structural anomaly of the proximal element of the hindlimb including the femur http://purl.obolibrary.org/obo/MP_0003857 abnormal hindlimb zeugopod morphology http://purl.obolibrary.org/obo/MP_0000556 abnormal hindlimb morphology any structural anomaly of the distal elements of the hindlimb including the tibia and fibula http://purl.obolibrary.org/obo/MP_0003858 enhanced coordination http://purl.obolibrary.org/obo/MP_0001516 abnormal motor coordination/ balance improved ability to execute integrated movements of muscle http://purl.obolibrary.org/obo/MP_0003859 abnormal Harderian gland physiology http://purl.obolibrary.org/obo/MP_0002164 abnormal gland physiology any functional anomaly of the retroocular sebaceous gland found within the orbit of mammals that possess a nictitating membrane (third eyelid); the chief products of the gland vary between different groups of vertebrates, and epithelial cells possess granules or vacuoles whose contents may be mucous, serous or lipid; in rodents, the Harderian gland is especially large and secretes lipids (by a merocrine mechanism), melatonin and porphyrins; ascribed functions include a role in lubrication and protection for the eyeball and nictitating membrane (by lipids), photoprotection (by porphyrin), photoreception (by regulation of the incidence of light on the retina), and thermoregulation (in some rodents) http://purl.obolibrary.org/obo/MP_0003860 abnormal carbon dioxide level http://purl.obolibrary.org/obo/MP_0003948 abnormal gas homeostasis anomalous concentration of CO2 in the blood, alveoli or other tissues resulting in the increased pressure of this component of body gases http://purl.obolibrary.org/obo/MP_0003861 abnormal nervous system development http://purl.obolibrary.org/obo/MP_0003632 abnormal nervous system morphology impaired or altered growth of the components of the nervous system http://purl.obolibrary.org/obo/MP_0003862 decreased aggression towards males http://purl.obolibrary.org/obo/MP_0003863 decreased aggression towards mice when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards male mice http://purl.obolibrary.org/obo/MP_0003863 decreased aggression towards mice http://purl.obolibrary.org/obo/MP_0005656 decreased aggression when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards other mice http://purl.obolibrary.org/obo/MP_0003864 abnormal midbrain development http://purl.obolibrary.org/obo/MP_0000913 abnormal brain development anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo http://purl.obolibrary.org/obo/MP_0003865 lymph node inflammation http://purl.obolibrary.org/obo/MP_0003762 abnormal immune organ physiology local accumulation of fluid, plasma proteins, and leukocytes in the lymph nodes http://purl.obolibrary.org/obo/MP_0003866 abnormal defecation http://purl.obolibrary.org/obo/MP_0001663 abnormal digestive system physiology anomaly in the discharge of feces from the body http://purl.obolibrary.org/obo/MP_0003867 increased defecation amount http://purl.obolibrary.org/obo/MP_0020147 abnormal defecation amount increase in the amount of discharge of feces from the body http://purl.obolibrary.org/obo/MP_0003868 abnormal feces composition http://purl.obolibrary.org/obo/MP_0001663 abnormal digestive system physiology increase or decrease in the amount of compounds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces http://purl.obolibrary.org/obo/MP_0003869 ectopic cartilage http://purl.obolibrary.org/obo/MP_0000163 abnormal cartilage morphology positional abnormality of cartilage http://purl.obolibrary.org/obo/MP_0003870 decreased urine glucose level http://purl.obolibrary.org/obo/MP_0001758 abnormal urine glucose level a reduced amount of glucose in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0003871 abnormal myelin sheath morphology http://purl.obolibrary.org/obo/MP_0005404 abnormal axon morphology any structural anomaly of the insulating envelope that surrounds nerve fibers or axons http://purl.obolibrary.org/obo/MP_0003872 absent heart right ventricle http://purl.obolibrary.org/obo/MP_0003920 abnormal heart right ventricle morphology missing the lower right chamber of the heart http://purl.obolibrary.org/obo/MP_0003873 pharyngeal arch hypoplasia http://purl.obolibrary.org/obo/MP_0006346 small pharyngeal arch underdevelopment or reduced size of the transient structures of the embryo that develop into regions of the head, neck and ears, usually due to reduced cell number http://purl.obolibrary.org/obo/MP_0003874 absent pharyngeal arches http://purl.obolibrary.org/obo/MP_0002884 abnormal pharyngeal arch morphology missing the transient structures of the embryo that develop into regions of the head, neck and ears http://purl.obolibrary.org/obo/MP_0003875 abnormal hair follicle regression http://purl.obolibrary.org/obo/MP_0000427 abnormal hair cycle abnormal length of time for the onset of catagen phase of the cyclic transformation of the hair follicle http://purl.obolibrary.org/obo/MP_0003877 abnormal serotonergic neuron morphology http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology any structural anomaly of the neurons that secrete serotonin http://purl.obolibrary.org/obo/MP_0003878 abnormal ear physiology http://purl.obolibrary.org/obo/MP_0005377 hearing/vestibular/ear phenotype any functional anomaly of the ear, not due to an anatomical defect http://purl.obolibrary.org/obo/MP_0003879 abnormal hair cell physiology http://purl.obolibrary.org/obo/MP_0010055 abnormal sensory neuron physiology any functional anomaly of the sensory epithelial cells of the inner ear http://purl.obolibrary.org/obo/MP_0003880 abnormal central pattern generator function http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology any functional anomaly of the neural networks that produce rhythmic patterned output without sensory input and underlie rhythmic motor patterns http://purl.obolibrary.org/obo/MP_0003881 abnormal nephron morphology http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology any structural anomaly of the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of Henle http://purl.obolibrary.org/obo/MP_0003882 abnormal pulse pressure http://purl.obolibrary.org/obo/MP_0000230 abnormal systemic arterial blood pressure anomaly in the difference between systolic and diastolic blood pressure http://purl.obolibrary.org/obo/MP_0003883 enlarged stomach http://purl.obolibrary.org/obo/MP_0000470 abnormal stomach morphology increased size of the stomach http://purl.obolibrary.org/obo/MP_0003884 decreased macrophage cell number http://purl.obolibrary.org/obo/MP_0020202 abnormal macrophage cell number fewer than the normal numbers of macrophages http://purl.obolibrary.org/obo/MP_0003885 abnormal rostral-caudal body axis extension http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology anomaly in or failure of the long (rostral-caudal) axis of the body to elongate normally once patterning has been established http://purl.obolibrary.org/obo/MP_0003886 abnormal embryonic epiblast morphology http://purl.obolibrary.org/obo/MP_0012103 abnormal bilaminar embryonic disc any structural anomaly of the transient structure derived from the inner cell mass which lies above the hypoblast; the epiblast tissue gives rise to the three primary germ layers (ectoderm, definitive endoderm, and mesoderm) and to the extraembryonic mesoderm of the visceral yolk sac, the allantois, and the amnion http://purl.obolibrary.org/obo/MP_0003887 increased hepatocyte apoptosis http://purl.obolibrary.org/obo/MP_0010080 abnormal hepatocyte physiology increase in the number of hepatocytes undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0003888 liver hemorrhage http://purl.obolibrary.org/obo/MP_0001634 internal hemorrhage bleeding within the liver http://purl.obolibrary.org/obo/MP_0003889 enhanced sensorimotor gating http://purl.obolibrary.org/obo/MP_0002634 abnormal sensorimotor gating amplification of the process by which inhibitory neural pathways filter multiple stimuli and allow attention to be focused on one stimulus; usually measured by pre-pulse inhibition (PPI) http://purl.obolibrary.org/obo/MP_0003890 abnormal embryonic-extraembryonic boundary morphology http://purl.obolibrary.org/obo/MP_0001672 abnormal embryogenesis/ development any structural anomaly in the delineating tissue and the segregation between the embryo proper and extraembryonic tissues http://purl.obolibrary.org/obo/MP_0003891 increased allantois apoptosis http://purl.obolibrary.org/obo/MP_0001726 abnormal allantois morphology increase in the number of cells of the allantois undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0003892 abnormal gastric gland morphology http://purl.obolibrary.org/obo/MP_0010792 abnormal stomach mucosa morphology any structural anomaly of any of the branched tubular glands in the mucosa of the fundus and body of the stomach that contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin http://purl.obolibrary.org/obo/MP_0003893 increased hepatocyte proliferation http://purl.obolibrary.org/obo/MP_0010080 abnormal hepatocyte physiology increase in the expansion rate of the hepatocyte cell population by cell division http://purl.obolibrary.org/obo/MP_0003894 abnormal Purkinje cell innervation http://purl.obolibrary.org/obo/MP_0002184 abnormal innervation any structural anomaly of the supply of nerve fibers that connect to the Purkinje cells http://purl.obolibrary.org/obo/MP_0003895 increased ectoderm apoptosis http://purl.obolibrary.org/obo/MP_0006042 increased apoptosis increase in the number of ectoderm cells undergoing programmed cell death during development http://purl.obolibrary.org/obo/MP_0003896 prolonged PR interval http://purl.obolibrary.org/obo/MP_0010519 atrioventricular block increase in the length of time between the beginning of atrial depolarization and the beginning of ventricular depolarization, measured by the interval from the beginning of the P wave to the beginning of the QRS complex http://purl.obolibrary.org/obo/MP_0003897 abnormal ST segment http://purl.obolibrary.org/obo/MP_0010508 abnormal heart electrocardiography waveform feature anomaly in the length of time between the end of S-wave and the beginning of T-wave; reflects the amount of time the ventricles remain electrically depolarized http://purl.obolibrary.org/obo/MP_0003898 abnormal QRS complex http://purl.obolibrary.org/obo/MP_0010508 abnormal heart electrocardiography waveform feature anomaly in the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction http://purl.obolibrary.org/obo/MP_0003899 abnormal QT interval http://purl.obolibrary.org/obo/MP_0010508 abnormal heart electrocardiography waveform feature anomaly in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time, and is measured from the beginning of the QRS complex to the end of the T wave http://purl.obolibrary.org/obo/MP_0003900 shortened QT interval http://purl.obolibrary.org/obo/MP_0003899 abnormal QT interval decrease in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time, and is measured from the beginning of the QRS complex to the end of the T wave http://purl.obolibrary.org/obo/MP_0003901 abnormal PR interval http://purl.obolibrary.org/obo/MP_0010508 abnormal heart electrocardiography waveform feature anomaly in the length of time between the beginning of atrial depolarization and the beginning of ventricular depolarization, measured by the interval from the beginning of the P wave to the beginning of the QRS complex http://purl.obolibrary.org/obo/MP_0003902 abnormal cell mass http://purl.obolibrary.org/obo/MP_0000358 abnormal cell morphology anomaly in the total physical bulk or volume of a cell compared to the normal state http://purl.obolibrary.org/obo/MP_0003903 increased cell mass http://purl.obolibrary.org/obo/MP_0003902 abnormal cell mass greater total physical bulk or volume of a cell compared to the normal state http://purl.obolibrary.org/obo/MP_0003904 decreased cell mass http://purl.obolibrary.org/obo/MP_0003902 abnormal cell mass reduction in the total physical bulk or volume of a cell compared to the normal state http://purl.obolibrary.org/obo/MP_0003905 abnormal aorta elastin content http://purl.obolibrary.org/obo/MP_0003211 abnormal aorta elastic fiber morphology anomaly in the physical amount of elastin in the aorta compared to the normal state http://purl.obolibrary.org/obo/MP_0003906 increased aorta elastin content http://purl.obolibrary.org/obo/MP_0003905 abnormal aorta elastin content greater physical amount of elastin in the aorta compared to the normal state http://purl.obolibrary.org/obo/MP_0003907 decreased aorta elastin content http://purl.obolibrary.org/obo/MP_0003905 abnormal aorta elastin content reduction in the physical amount of elastin in the aorta compared to the normal state http://purl.obolibrary.org/obo/MP_0003908 decreased stereotypic behavior http://purl.obolibrary.org/obo/MP_0001408 stereotypic behavior less frequent incidence of repetitive, invariant, persistent motor patterns that do not appear to be purposeful http://purl.obolibrary.org/obo/MP_0003913 increased heart right ventricle weight http://purl.obolibrary.org/obo/MP_0020205 abnormal heart right ventricle weight greater than average weight of the right ventricle compared to the average http://purl.obolibrary.org/obo/MP_0003914 decreased heart right ventricle weight http://purl.obolibrary.org/obo/MP_0020205 abnormal heart right ventricle weight less than average weight of the right ventricle compared to the average http://purl.obolibrary.org/obo/MP_0003915 increased left ventricle weight http://purl.obolibrary.org/obo/MP_0020204 abnormal heart left ventricle weight greater than average weight of the left ventricle compared to the average http://purl.obolibrary.org/obo/MP_0003916 decreased heart left ventricle weight http://purl.obolibrary.org/obo/MP_0020204 abnormal heart left ventricle weight less than average weight of the left ventricle compared to the average http://purl.obolibrary.org/obo/MP_0003917 increased kidney weight http://purl.obolibrary.org/obo/MP_0003068 enlarged kidney greater weight of the organs responsible for urine secretion http://purl.obolibrary.org/obo/MP_0003918 decreased kidney weight http://purl.obolibrary.org/obo/MP_0002989 small kidney reduced weight of the organs responsible for urine secretion http://purl.obolibrary.org/obo/MP_0003920 abnormal heart right ventricle morphology http://purl.obolibrary.org/obo/MP_0005294 abnormal heart ventricle morphology any structural anomaly of the right lower chamber of the heart http://purl.obolibrary.org/obo/MP_0003921 abnormal heart left ventricle morphology http://purl.obolibrary.org/obo/MP_0005294 abnormal heart ventricle morphology any structural anomaly of the left lower chamber of the heart http://purl.obolibrary.org/obo/MP_0003922 abnormal heart right atrium morphology http://purl.obolibrary.org/obo/MP_0003105 abnormal heart atrium morphology any structural anomaly of the right upper chamber of the heart http://purl.obolibrary.org/obo/MP_0003923 abnormal heart left atrium morphology http://purl.obolibrary.org/obo/MP_0003105 abnormal heart atrium morphology any structural anomaly of the left upper chamber of the heart http://purl.obolibrary.org/obo/MP_0003924 herniated diaphragm http://purl.obolibrary.org/obo/MP_0002279 abnormal diaphragm morphology protrusion of abdominal contents into the thoracic cavity through the diaphragm http://purl.obolibrary.org/obo/MP_0003925 abnormal cellular glucose import http://purl.obolibrary.org/obo/MP_0005621 abnormal cell physiology anomaly in the ability of a cell to take in glucose from the environment http://purl.obolibrary.org/obo/MP_0003926 impaired cellular glucose import http://purl.obolibrary.org/obo/MP_0003925 abnormal cellular glucose import reduced ability of a cell to take in glucose from the environment http://purl.obolibrary.org/obo/MP_0003927 enhanced cellular glucose import http://purl.obolibrary.org/obo/MP_0003925 abnormal cellular glucose import improved ability of a cell to take in glucose from the environment http://purl.obolibrary.org/obo/MP_0003928 increased heart rate variability http://purl.obolibrary.org/obo/MP_0004122 abnormal sinus arrhythmia increased variation of beat-to-beat intervals of the heart that occurs in conjunction with the respiratory cycle http://purl.obolibrary.org/obo/MP_0003929 decreased heart rate variability http://purl.obolibrary.org/obo/MP_0004122 abnormal sinus arrhythmia reduced variation of beat-to-beat intervals of the heart that occurs in conjunction with the respiratory cycle http://purl.obolibrary.org/obo/MP_0003930 abnormal tooth hard tissue morphology http://purl.obolibrary.org/obo/MP_0002100 abnormal tooth morphology any structural anomaly of the hard portion of the tooth surrounding the pulp, including the dentin, enamel and the cementum on the root http://purl.obolibrary.org/obo/MP_0003931 absent molars http://purl.obolibrary.org/obo/MP_0002689 abnormal molar morphology absence of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface http://purl.obolibrary.org/obo/MP_0003932 abnormal molar crown morphology http://purl.obolibrary.org/obo/MP_0002689 abnormal molar morphology any structural anomaly of the part of a molar that is covered by enamel http://purl.obolibrary.org/obo/MP_0003933 abnormal cementum morphology http://purl.obolibrary.org/obo/MP_0003930 abnormal tooth hard tissue morphology any strucutral anomaly in the bonelike rigid connective tissue covering the root of a tooth http://purl.obolibrary.org/obo/MP_0003934 abnormal pancreas development http://purl.obolibrary.org/obo/MP_0001944 abnormal pancreas morphology anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream http://purl.obolibrary.org/obo/MP_0003935 abnormal craniofacial development http://purl.obolibrary.org/obo/MP_0000428 abnormal craniofacial morphology anomaly in the process of forming the face and/or cranium http://purl.obolibrary.org/obo/MP_0003936 abnormal reproductive system development http://purl.obolibrary.org/obo/MP_0002160 abnormal reproductive system morphology developmental anomaly of any of the organs involved in the reproductive system http://purl.obolibrary.org/obo/MP_0003938 abnormal ear development http://purl.obolibrary.org/obo/MP_0002102 abnormal ear morphology developmental anomaly of any of the structures involved in the ear or vestibular system http://purl.obolibrary.org/obo/MP_0003939 abnormal myotome morphology http://purl.obolibrary.org/obo/MP_0000733 abnormal muscle development any structural anomaly of the mesoderm that is derived from the somite that is fated to become the musculature http://purl.obolibrary.org/obo/MP_0003940 abnormal dermatome morphology http://purl.obolibrary.org/obo/MP_0003941 abnormal skin development any structural anomaly in the mesoderm that is derived from the somite that is fated to become the dermis http://purl.obolibrary.org/obo/MP_0003941 abnormal skin development http://purl.obolibrary.org/obo/MP_0002060 abnormal skin morphology anomaly in the formation of the membranous protective covering of the body http://purl.obolibrary.org/obo/MP_0003942 abnormal urinary system development http://purl.obolibrary.org/obo/MP_0000516 abnormal renal/urinary system morphology any anomaly in the differentiation of the organ system that produces, stores, and eliminates urine http://purl.obolibrary.org/obo/MP_0003943 abnormal hepatobiliary system development http://purl.obolibrary.org/obo/MP_0002138 abnormal hepatobiliary system morphology developmental anomaly of any of the tissues of the liver or biliary system http://purl.obolibrary.org/obo/MP_0003944 abnormal T cell subpopulation ratio http://purl.obolibrary.org/obo/MP_0006387 abnormal T cell number deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples http://purl.obolibrary.org/obo/MP_0003945 abnormal lymphocyte physiology http://purl.obolibrary.org/obo/MP_0002442 abnormal leukocyte physiology any functional anomaly of any of the white blood cells that includes B cells, T cells, and NK cells http://purl.obolibrary.org/obo/MP_0003946 renal necrosis http://purl.obolibrary.org/obo/MP_0009641 kidney degeneration morphological changes resulting from pathological death of renal tissue; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0003947 abnormal cholesterol level http://purl.obolibrary.org/obo/MP_0012224 abnormal sterol level anomaly in the amount in the body of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues http://purl.obolibrary.org/obo/MP_0003948 abnormal gas homeostasis http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis anomaly in the processes involved in the maintenance of an internal equilibrium of gaseous elements in animal tissues or blood http://purl.obolibrary.org/obo/MP_0003949 abnormal circulating lipid level http://purl.obolibrary.org/obo/MP_0009642 abnormal blood homeostasis anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood http://purl.obolibrary.org/obo/MP_0003950 abnormal plasma membrane morphology http://purl.obolibrary.org/obo/MP_0000358 abnormal cell morphology any structural anomaly of the semi-permeable membrane that encloses the cytoplasm of a cell http://purl.obolibrary.org/obo/MP_0003951 abnormal copper homeostasis http://purl.obolibrary.org/obo/MP_0005636 abnormal mineral homeostasis anomaly in the processes involved in the maintenance of an internal equilibrium of copper that is a cofactor in a number of proteins including amine oxidases and chaperone proteins http://purl.obolibrary.org/obo/MP_0003952 abnormal copper level http://purl.obolibrary.org/obo/MP_0003951 abnormal copper homeostasis anomaly in the concentration in the body of the metallic element atom that has formula Cu, and normally occurs as a cofactor for a number of proteins including amine oxidases and chaperone proteins http://purl.obolibrary.org/obo/MP_0003953 abnormal hormone level http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone http://purl.obolibrary.org/obo/MP_0003954 abnormal Reichert's membrane morphology http://purl.obolibrary.org/obo/MP_0011187 abnormal parietal endoderm morphology any structural anomaly of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm during placenta morphogenesis and is secreted by the distal parietal endoderm; required for the maternofetal exchange of nutrients and is important for the postgastrulation development http://purl.obolibrary.org/obo/MP_0003955 abnormal ultimobranchial body morphology http://purl.obolibrary.org/obo/MP_0006031 abnormal pharyngeal pouch morphology any structural anomaly of the outpocketing of the caudal-most branchial pouch of the embryo (interpreted as a fifth pouch in human or as the ventral component of the fourth pouch in mouse) that fuses with the thyroid diverticulum, ultimately giving rise to calcitonin-producing parafollicular cells (aka C-cells) which function in calcium homeostasis; in most mammals, these parafollicular cells fully disperse with the endodermally derived follicular cells of the thyroid by birth http://purl.obolibrary.org/obo/MP_0003956 abnormal body size http://purl.obolibrary.org/obo/MP_0002089 abnormal postnatal growth/weight/body size anomaly in the average body weight, height and/or length of an organism compared to controls http://purl.obolibrary.org/obo/MP_0003957 abnormal nitric oxide homeostasis http://purl.obolibrary.org/obo/MP_0003948 abnormal gas homeostasis anomaly in the processes involved in the maintenance of an internal equilibrium of nitric oxide, a free radical gas and a potent vasodilator http://purl.obolibrary.org/obo/MP_0003958 heart valve hyperplasia http://purl.obolibrary.org/obo/MP_0000285 abnormal heart valve morphology overdevelopment or increased size, usually due an increased number of cells of the heart valves http://purl.obolibrary.org/obo/MP_0003959 abnormal lean body mass http://purl.obolibrary.org/obo/MP_0005451 abnormal body composition anomaly in the amount of the fat-free physical bulk or volume of the body including all its components except adipose tissue http://purl.obolibrary.org/obo/MP_0003960 increased lean body mass http://purl.obolibrary.org/obo/MP_0003959 abnormal lean body mass greater amount of the fat-free physical bulk or volume of the body including all its components except adipose (fat) tissue http://purl.obolibrary.org/obo/MP_0003961 decreased lean body mass http://purl.obolibrary.org/obo/MP_0003959 abnormal lean body mass reduced amount of the fat-free physical bulk or volume of the body including all its components except adipose (fat) tissue http://purl.obolibrary.org/obo/MP_0003962 abnormal adrenaline level http://purl.obolibrary.org/obo/MP_0011479 abnormal catecholamine level aberrant concentration in the blood or tissues of this catecholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels http://purl.obolibrary.org/obo/MP_0003963 abnormal corticosterone level http://purl.obolibrary.org/obo/MP_0003953 abnormal hormone level anomalous blood or tissue amount of an adrenocortical steroid that induces glycogen deposition and regulates sodium conservation and potassium secretion http://purl.obolibrary.org/obo/MP_0003964 abnormal noradrenaline level http://purl.obolibrary.org/obo/MP_0011479 abnormal catecholamine level aberrant amount of the hormone secreted by the adrenal medulla and acts as a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS; noradrenaline is the demethylated biosynthetic precursor of epinephrine http://purl.obolibrary.org/obo/MP_0003965 abnormal pituitary hormone level http://purl.obolibrary.org/obo/MP_0003953 abnormal hormone level aberration in the blood or tissue concentration of any of the hormones secreted by the pituitary http://purl.obolibrary.org/obo/MP_0003966 abnormal adrenocorticotropin level http://purl.obolibrary.org/obo/MP_0003965 abnormal pituitary hormone level anomaly in the level of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex http://purl.obolibrary.org/obo/MP_0003967 abnormal follicle stimulating hormone level http://purl.obolibrary.org/obo/MP_0003965 abnormal pituitary hormone level anomalous concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis http://purl.obolibrary.org/obo/MP_0003968 abnormal growth hormone level http://purl.obolibrary.org/obo/MP_0003965 abnormal pituitary hormone level anomalous concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization http://purl.obolibrary.org/obo/MP_0003969 abnormal luteinizing hormone level http://purl.obolibrary.org/obo/MP_0003965 abnormal pituitary hormone level aberrant levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary http://purl.obolibrary.org/obo/MP_0003970 abnormal prolactin level http://purl.obolibrary.org/obo/MP_0003965 abnormal pituitary hormone level anomalous concentration of the hormone that stimulates milk secretion http://purl.obolibrary.org/obo/MP_0003971 abnormal thyroid-stimulating hormone level http://purl.obolibrary.org/obo/MP_0003965 abnormal pituitary hormone level anomalous concentration of the hormone that stimulates the growth and function of the thyroid gland http://purl.obolibrary.org/obo/MP_0003972 decreased pituitary hormone level http://purl.obolibrary.org/obo/MP_0003965 abnormal pituitary hormone level less than the expected amount of any of the pituitary hormones in the blood or tissues http://purl.obolibrary.org/obo/MP_0003973 increased pituitary hormone level http://purl.obolibrary.org/obo/MP_0003965 abnormal pituitary hormone level greater than the expected amount of any of the pituitary hormones in the blood or tissues http://purl.obolibrary.org/obo/MP_0003974 abnormal endocardium morphology http://purl.obolibrary.org/obo/MP_0010545 abnormal heart layer morphology any structural anomaly of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the heart http://purl.obolibrary.org/obo/MP_0003975 increased circulating VLDL triglyceride level http://purl.obolibrary.org/obo/MP_0001552 increased circulating triglyceride level higher than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue http://purl.obolibrary.org/obo/MP_0003976 decreased circulating VLDL triglyceride level http://purl.obolibrary.org/obo/MP_0002644 decreased circulating triglyceride level lower than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue http://purl.obolibrary.org/obo/MP_0003977 abnormal circulating carnitine level http://purl.obolibrary.org/obo/MP_0005311 abnormal circulating amino acid level aberrant concentration in the blood of carnitine, a quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane http://purl.obolibrary.org/obo/MP_0003978 decreased circulating carnitine level http://purl.obolibrary.org/obo/MP_0003977 abnormal circulating carnitine level lower than normal blood concentration of this quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane http://purl.obolibrary.org/obo/MP_0003979 increased circulating carnitine level http://purl.obolibrary.org/obo/MP_0003977 abnormal circulating carnitine level greater than normal blood concentration of this quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane http://purl.obolibrary.org/obo/MP_0003980 increased circulating phospholipid level http://purl.obolibrary.org/obo/MP_0006084 abnormal circulating phospholipid level greater concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group http://purl.obolibrary.org/obo/MP_0003981 decreased circulating phospholipid level http://purl.obolibrary.org/obo/MP_0006084 abnormal circulating phospholipid level reduced concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group http://purl.obolibrary.org/obo/MP_0003982 increased cholesterol level http://purl.obolibrary.org/obo/MP_0012226 increased sterol level greater than normal amount in the body of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues http://purl.obolibrary.org/obo/MP_0003983 decreased cholesterol level http://purl.obolibrary.org/obo/MP_0012225 decreased sterol level less than normal amount in the body of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues http://purl.obolibrary.org/obo/MP_0003984 embryonic growth retardation http://purl.obolibrary.org/obo/MP_0010865 prenatal growth retardation slow or limited development during the embryonic period (sensu Mus: up to E14, or the completion of organogenesis) http://purl.obolibrary.org/obo/MP_0003985 renal fibrosis http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology formation of fibrous tissue in the kidney as a result of repair or a reactive process http://purl.obolibrary.org/obo/MP_0003986 small cochlear ganglion http://purl.obolibrary.org/obo/MP_0002855 abnormal cochlear ganglion morphology reduced size of the cochlear ganglion or of the sensory neuron cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve) http://purl.obolibrary.org/obo/MP_0003987 small vestibular ganglion http://purl.obolibrary.org/obo/MP_0002856 abnormal vestibular ganglion morphology reduced size of the vestibular ganglion or of the sensory neuron cell bodies associated with the eighth cranial nerve http://purl.obolibrary.org/obo/MP_0003988 disorganized embryonic tissue http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology a lack of the regular arrangement of any embryonic tissues http://purl.obolibrary.org/obo/MP_0003989 abnormal barrel cortex morphology http://purl.obolibrary.org/obo/MP_0000860 abnormal primary somatosensory cortex morphology any structural anomaly of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae http://purl.obolibrary.org/obo/MP_0003990 decreased neurotransmitter release http://purl.obolibrary.org/obo/MP_0005445 abnormal neurotransmitter secretion reduced production or release of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells http://purl.obolibrary.org/obo/MP_0003991 arteriosclerosis http://purl.obolibrary.org/obo/MP_0002191 abnormal artery morphology thickening, hardening and/or loss of elasticity of the walls of arteries http://purl.obolibrary.org/obo/MP_0003992 increased mortality induced by ionizing radiation http://purl.obolibrary.org/obo/MP_0020149 abnormal mortality induced by ionizing radiation greater sensitivity to doses of ionizing radiation that include ultraviolet light, X-rays, or gamma rays, resulting in death http://purl.obolibrary.org/obo/MP_0003993 abnormal ventral spinal root morphology http://purl.obolibrary.org/obo/MP_0001077 abnormal spinal nerve morphology any structural anomaly of the anterior bundle of nerves emerging from the spinal cord to join with the posterior/dorsal nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves http://purl.obolibrary.org/obo/MP_0003994 abnormal dorsal spinal root morphology http://purl.obolibrary.org/obo/MP_0001077 abnormal spinal nerve morphology any structural anomaly of the posterior bundle of nerves emerging from the spinal cord to join with the anterior/ventral nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves http://purl.obolibrary.org/obo/MP_0003995 abnormal uterine artery morphology http://purl.obolibrary.org/obo/MP_0011655 abnormal systemic artery morphology any structural anomaly of the branch of the internal iliac artery that supplies the uterus and the upper part of the vagina http://purl.obolibrary.org/obo/MP_0003996 clonic seizures http://purl.obolibrary.org/obo/MP_0000947 convulsive seizures increased number or decreased threshold for the induction of a seizure characterized by unilateral or bilateral rhythmic jerking movements of the arms and legs caused by alternating contraction and relaxation of muscle http://purl.obolibrary.org/obo/MP_0003997 tonic-clonic seizures http://purl.obolibrary.org/obo/MP_0000947 convulsive seizures increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements http://purl.obolibrary.org/obo/MP_0003998 decreased thermal nociceptive threshold http://purl.obolibrary.org/obo/MP_0005407 hyperalgesia a lower than average point at which thermal pain sensation is first detectable http://purl.obolibrary.org/obo/MP_0003999 enhanced passive avoidance behavior http://purl.obolibrary.org/obo/MP_0012313 enhanced avoidance learning behavior increase in the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously http://purl.obolibrary.org/obo/MP_0004000 impaired passive avoidance behavior http://purl.obolibrary.org/obo/MP_0012312 impaired avoidance learning behavior decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously http://purl.obolibrary.org/obo/MP_0004001 decreased hepatocyte proliferation http://purl.obolibrary.org/obo/MP_0010080 abnormal hepatocyte physiology reduction in the expansion rate of the hepatocyte cell population by cell division http://purl.obolibrary.org/obo/MP_0004002 abnormal jejunum morphology http://purl.obolibrary.org/obo/MP_0000496 abnormal small intestine morphology any structural anomaly of the portion of the small intestine that extends from the duodenum to the ileum http://purl.obolibrary.org/obo/MP_0004003 abnormal vascular endothelial cell physiology http://purl.obolibrary.org/obo/MP_0000249 abnormal blood vessel physiology anomaly in the function of the cells that line the vasculature http://purl.obolibrary.org/obo/MP_0004004 patent ductus venosus http://purl.obolibrary.org/obo/MP_0002725 abnormal vein morphology failure of the embryonic connection between the portal vein and inferior vena cava formed by the left umbilical vein (that allows oxygenated blood to bypass the developing liver) to close in adults http://purl.obolibrary.org/obo/MP_0004005 impaired contractility of intestinal smooth muscle http://purl.obolibrary.org/obo/MP_0000740 impaired smooth muscle contractility inability or reduced ability of intestinal smooth muscle to shorten or to develop increased tension http://purl.obolibrary.org/obo/MP_0004006 impaired contractility of jejunal smooth muscle http://purl.obolibrary.org/obo/MP_0004005 impaired contractility of intestinal smooth muscle inability or reduced ability of the jejunal smooth muscle to shorter or to develop increased tension http://purl.obolibrary.org/obo/MP_0004007 abnormal lung vasculature morphology http://purl.obolibrary.org/obo/MP_0001614 abnormal blood vessel morphology any structural anomaly of the blood vessels of the lung http://purl.obolibrary.org/obo/MP_0004008 abnormal GABA-mediated receptor currents http://purl.obolibrary.org/obo/MP_0002206 abnormal CNS synaptic transmission change in the measured amplitude, current density or duration of response to stimulation of GABA receptors http://purl.obolibrary.org/obo/MP_0004009 abnormal diastolic filling velocity http://purl.obolibrary.org/obo/MP_0002128 abnormal blood circulation anomaly in the rate of fluid inflow to the heart during diastole compared to controls; usually measured in the left ventricle; altered filling velocity often contributes to various cardiovascular disorders http://purl.obolibrary.org/obo/MP_0004010 increased diastolic filling velocity http://purl.obolibrary.org/obo/MP_0004009 abnormal diastolic filling velocity greater rate of fluid inflow to the heart during diastole compared to controls; usually measured in the left ventricle; altered filling velocity often contributes to various cardiovascular disorders http://purl.obolibrary.org/obo/MP_0004011 decreased diastolic filling velocity http://purl.obolibrary.org/obo/MP_0004009 abnormal diastolic filling velocity reduction in the rate of fluid inflow to the heart during diastole compared to controls; usually measured in the left ventricle; altered filling velocity often contributes to various cardiovascular disorders http://purl.obolibrary.org/obo/MP_0004012 increased pulmonary artery pressure http://purl.obolibrary.org/obo/MP_0003547 abnormal pulmonary pressure increased pulmonary pressure compared to controls http://purl.obolibrary.org/obo/MP_0004013 decreased pulmonary artery pressure http://purl.obolibrary.org/obo/MP_0003547 abnormal pulmonary pressure reduced pulmonary pressure compared to controls http://purl.obolibrary.org/obo/MP_0004014 abnormal uterine environment http://purl.obolibrary.org/obo/MP_0009661 abnormal pregnancy anomaly or inability of the uterus to support embryonic development http://purl.obolibrary.org/obo/MP_0004015 abnormal oviduct environment http://purl.obolibrary.org/obo/MP_0012018 abnormal oviduct physiology anomaly or inability of the oviduct to support egg viability http://purl.obolibrary.org/obo/MP_0004016 decreased bone mass http://purl.obolibrary.org/obo/MP_0003795 abnormal bone structure a reduction in the total amount of bone tissue contained in the skeleton http://purl.obolibrary.org/obo/MP_0004017 duplex kidney http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology a kidney that is split into two separate collecting systems; there may be a duplex ureter or a single ureter; may present unilaterally or bilaterally http://purl.obolibrary.org/obo/MP_0004018 abnormal galactose homeostasis http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis anomaly in the processes involved in the maintenance of an internal equilibrium of galactose in the fluids and tissues http://purl.obolibrary.org/obo/MP_0004019 abnormal vitamin homeostasis http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis anomaly in the processes involved in the maintenance of an internal equilibrium of organic substances found in food and are not synthesized by the body and are necessary in trace amounts for normal metabolic function http://purl.obolibrary.org/obo/MP_0004020 polyhydramnios http://purl.obolibrary.org/obo/MP_0001784 abnormal fluid regulation abnormally high amniotic fluid volume; may result from maternal diabetes, chromosomal abnormalities or other congenital abnormalities http://purl.obolibrary.org/obo/MP_0004021 abnormal rod electrophysiology http://purl.obolibrary.org/obo/MP_0005551 abnormal eye electrophysiology any functional anomaly of dark adapted vision mediated by the rods http://purl.obolibrary.org/obo/MP_0004022 abnormal cone electrophysiology http://purl.obolibrary.org/obo/MP_0005551 abnormal eye electrophysiology any functional anomaly of light adapted vision mediated by the cones http://purl.obolibrary.org/obo/MP_0004023 abnormal chromosome number http://purl.obolibrary.org/obo/MP_0003111 abnormal cell nucleus morphology chromosome count is other than the expected diploid chromosome number http://purl.obolibrary.org/obo/MP_0004024 aneuploidy http://purl.obolibrary.org/obo/MP_0004023 abnormal chromosome number chromosome count is not an exact multiple of the haploid number http://purl.obolibrary.org/obo/MP_0004025 polyploidy http://purl.obolibrary.org/obo/MP_0004023 abnormal chromosome number more than two chromosome sets are present http://purl.obolibrary.org/obo/MP_0004026 monosomy http://purl.obolibrary.org/obo/MP_0004024 aneuploidy one chromosome missing from an otherwise diploid chromosome set http://purl.obolibrary.org/obo/MP_0004027 trisomy http://purl.obolibrary.org/obo/MP_0004024 aneuploidy presence of an extra chromosome in an otherwise diploid chromosome set http://purl.obolibrary.org/obo/MP_0004028 chromosome breakage http://purl.obolibrary.org/obo/MP_0008866 chromosomal instability chromosome instability in the form of increased frequency of spontaneous breakage with or without rearrangements http://purl.obolibrary.org/obo/MP_0004029 spontaneous chromosome breakage http://purl.obolibrary.org/obo/MP_0004028 chromosome breakage chromosome breakage due to inherent instability of chromosomes http://purl.obolibrary.org/obo/MP_0004030 induced chromosome breakage http://purl.obolibrary.org/obo/MP_0004028 chromosome breakage chromosome breakage following treatment with a DNA-damaging agent http://purl.obolibrary.org/obo/MP_0004031 insulitis http://purl.obolibrary.org/obo/MP_0001869 pancreas inflammation a histological change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells http://purl.obolibrary.org/obo/MP_0004032 abnormal interventricular groove morphology http://purl.obolibrary.org/obo/MP_0005294 abnormal heart ventricle morphology any structural anomaly of the indentation dividing the two ventricles, comprised of the sulcus interventricularis anterior and the sulcus interventricularis posterior http://purl.obolibrary.org/obo/MP_0004033 supernumerary teeth http://purl.obolibrary.org/obo/MP_0002100 abnormal tooth morphology occurrence of more than the usual number of teeth http://purl.obolibrary.org/obo/MP_0004034 belly blaze http://purl.obolibrary.org/obo/MP_0002075 abnormal coat/hair pigmentation the appearance of a stripe or zigzag of white fur on the ventrum http://purl.obolibrary.org/obo/MP_0004035 abnormal sublingual gland morphology http://purl.obolibrary.org/obo/MP_0003792 abnormal major salivary gland morphology any structural anomaly of the small mucin-producing salivary glands in the floor of the mouth beneath the tongue, anterior to the submandibular gland http://purl.obolibrary.org/obo/MP_0004036 abnormal muscle relaxation http://purl.obolibrary.org/obo/MP_0002106 abnormal muscle physiology altered ability of the muscle to lengthen following contractions http://purl.obolibrary.org/obo/MP_0004037 increased muscle relaxation http://purl.obolibrary.org/obo/MP_0004036 abnormal muscle relaxation greater than the normal ability of the muscle to lengthen following contractions or increase in the ability of the muscle to lengthen following contractions http://purl.obolibrary.org/obo/MP_0004038 lymphangiectasis http://purl.obolibrary.org/obo/MP_0010200 enlarged lymphatic vessel dilation of the lymphatic vessels, the basic process that may result in the formation of a lymphangioma http://purl.obolibrary.org/obo/MP_0004039 abnormal cardiac cell glucose uptake http://purl.obolibrary.org/obo/MP_0004130 abnormal muscle cell glucose uptake anomalous ability of the cells of the heart to take in glucose http://purl.obolibrary.org/obo/MP_0004040 altered susceptibility to kidney reperfusion injury http://purl.obolibrary.org/obo/MP_0005164 abnormal response to injury a change in the likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia http://purl.obolibrary.org/obo/MP_0004041 increased susceptibility to kidney reperfusion injury http://purl.obolibrary.org/obo/MP_0004040 altered susceptibility to kidney reperfusion injury an increased likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia http://purl.obolibrary.org/obo/MP_0004042 decreased susceptibility to kidney reperfusion injury http://purl.obolibrary.org/obo/MP_0005166 decreased susceptibility to injury a diminished likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia http://purl.obolibrary.org/obo/MP_0004043 abnormal pH regulation http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis anomaly in the function of the buffer systems of the body in combination with the respiratory and renal systems that control the relative acidity or alkalinity of the body, as measured by the concentration of hydrogen ion http://purl.obolibrary.org/obo/MP_0004044 aortic dissection http://purl.obolibrary.org/obo/MP_0000272 abnormal aorta morphology a pathologic process, characterized by splitting of the media layer of the aorta, which leads to formation of a dissecting aneurysm http://purl.obolibrary.org/obo/MP_0004045 abnormal cell cycle checkpoint function http://purl.obolibrary.org/obo/MP_0003077 abnormal cell cycle anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable http://purl.obolibrary.org/obo/MP_0004046 abnormal mitosis http://purl.obolibrary.org/obo/MP_0003077 abnormal cell cycle anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) http://purl.obolibrary.org/obo/MP_0004047 abnormal milk composition http://purl.obolibrary.org/obo/MP_0001882 abnormal lactation anomaly in the protein or lipid content or the appearance of milk http://purl.obolibrary.org/obo/MP_0004049 increased acute promyelocytic leukemia incidence http://purl.obolibrary.org/obo/MP_0002026 increased leukemia incidence higher than normal incidence of cancer characterized by rapid onset of abnormal leukocyte proliferation, manifesting as a severe bleeding disorder from coagulation abnormalities, and bone marrow infiltration of abnormal promyelocytes and myelocytes http://purl.obolibrary.org/obo/MP_0004053 abnormal synchondrosis http://purl.obolibrary.org/obo/MP_0000164 abnormal cartilage development anomalous or persistent cartilaginous fusion of two bones http://purl.obolibrary.org/obo/MP_0004054 abnormal periocular mesenchyme morphology http://purl.obolibrary.org/obo/MP_0011260 abnormal head mesenchyme morphology any structural anomaly of the mesenchymal cells that give rise to the corneal endothelium, corneal stroma, sclera, iris stroma, ciliary muscle, ciliary stroma, and trabecular meshwork of the eye http://purl.obolibrary.org/obo/MP_0004055 atrium hypoplasia http://purl.obolibrary.org/obo/MP_0003105 abnormal heart atrium morphology underdevelopment or reduced size of one or both of the two upper chambers of the heart, usually due to reduced cell number http://purl.obolibrary.org/obo/MP_0004056 abnormal myocardium compact layer morphology http://purl.obolibrary.org/obo/MP_0005329 abnormal myocardium layer morphology any structural anomaly of the outer, dense layer of the myocardium uniting the epicardium and myocardium http://purl.obolibrary.org/obo/MP_0004057 thin myocardium compact layer http://purl.obolibrary.org/obo/MP_0004056 abnormal myocardium compact layer morphology reduced thickness of the outer, dense layer of the myocardium http://purl.obolibrary.org/obo/MP_0004058 abnormal ventricle papillary muscle morphology http://purl.obolibrary.org/obo/MP_0010499 abnormal ventricle myocardium morphology any structural anomaly of one of the group of myocardial bundles which terminate in the chordae tendineae that attach to the cusps of the atrioventricular valves; each ventricle has an anterior and a posterior papillary muscle; the right ventricle sometimes has a septal papillary muscle http://purl.obolibrary.org/obo/MP_0004060 absent papillary muscle http://purl.obolibrary.org/obo/MP_0004058 abnormal ventricle papillary muscle morphology absence of one of the group of myocardial bundles which terminate in the chordae tendineae that attach to the cusps of the atrioventricular valves; each ventricle has an anterior and a posterior papillary muscle; the right ventricle sometimes has a septal papillary muscle http://purl.obolibrary.org/obo/MP_0004061 papillary muscle hypoplasia http://purl.obolibrary.org/obo/MP_0004058 abnormal ventricle papillary muscle morphology underdevelopment or reduced size, usually due to a reduced number of cells, in the papillary muscle http://purl.obolibrary.org/obo/MP_0004062 dilated heart right atrium http://purl.obolibrary.org/obo/MP_0003922 abnormal heart right atrium morphology the luminal space of the right upper chamber of the heart is increased in volume or area, usually with an increase in contained fluid http://purl.obolibrary.org/obo/MP_0004063 dilated heart left atrium http://purl.obolibrary.org/obo/MP_0003923 abnormal heart left atrium morphology the luminal space of the left upper chamber of the heart is increased in volume or area, usually with an increase in contained fluid http://purl.obolibrary.org/obo/MP_0004064 decreased susceptibility to induced muscular atrophy http://purl.obolibrary.org/obo/MP_0002269 muscular atrophy less than expected wasting of muscle tissue after experimental manipulation (starvation, neurectomy, immobilization, etc) http://purl.obolibrary.org/obo/MP_0004065 increased susceptibility to induced muscular atrophy http://purl.obolibrary.org/obo/MP_0002269 muscular atrophy greater than expected wasting of muscle tissue after experimental manipulation (starvation, neurectomy, immobilization, etc) http://purl.obolibrary.org/obo/MP_0004066 abnormal primitive node morphology http://purl.obolibrary.org/obo/MP_0002231 abnormal primitive streak morphology any structural anomaly of the regional thickening of cells at the rostral tip of the vertebrate primitive streak through which gastrulating cells migrate anteriorly to form tissues in the future head and neck; this region organizes the formation of the three embryonic layers and establishes the longitudinal axis and the polarity of the embryo http://purl.obolibrary.org/obo/MP_0004067 abnormal trabecula carnea morphology http://purl.obolibrary.org/obo/MP_0010499 abnormal ventricle myocardium morphology any structural anomaly of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart http://purl.obolibrary.org/obo/MP_0004068 dilated dorsal aorta http://purl.obolibrary.org/obo/MP_0004787 abnormal dorsal aorta morphology stretched or widened aperture of the luminal space of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation http://purl.obolibrary.org/obo/MP_0004069 abnormal muscle spindle morphology http://purl.obolibrary.org/obo/MP_0000990 abnormal skeletal muscle mechanoreceptor morphology any structural anomaly of the sensory organs in muscle that are involved in the stretch reflex http://purl.obolibrary.org/obo/MP_0004070 abnormal P wave http://purl.obolibrary.org/obo/MP_0010508 abnormal heart electrocardiography waveform feature any anomaly in the P wave which represents atrial depolarization and corresponds to electrical impulses rather than mechanical atria contractions; irregular or absent P waves may indicate arrhythmia and the shape of the P waves may indicate atrial problems http://purl.obolibrary.org/obo/MP_0004071 prolonged P wave http://purl.obolibrary.org/obo/MP_0010520 sinoatrial block increase in the length of time of the P wave electrical impulses, measured from the beginning to the end of the P wave http://purl.obolibrary.org/obo/MP_0004072 abnormal frontal plane axis http://purl.obolibrary.org/obo/MP_0003137 abnormal impulse conducting system conduction any anomaly found in the sum of all electrical currents in the heart during systole http://purl.obolibrary.org/obo/MP_0004073 caudal body truncation http://purl.obolibrary.org/obo/MP_0005221 abnormal rostral-caudal axis patterning caudal part of body truncated; typically with the rostral portion of the body relatively normal http://purl.obolibrary.org/obo/MP_0004074 abnormal Schwann cell precursor morphology http://purl.obolibrary.org/obo/MP_0001106 abnormal Schwann cell morphology any structural anomaly of the progenitors of cells that sheath the axons of the peripheral nervous system http://purl.obolibrary.org/obo/MP_0004075 decreased Schwann cell precursor number http://purl.obolibrary.org/obo/MP_0004074 abnormal Schwann cell precursor morphology fewer numbers than normal of the progenitors of cells that sheath the axons of the peripheral nervous system http://purl.obolibrary.org/obo/MP_0004076 abnormal vitelline vascular remodeling http://purl.obolibrary.org/obo/MP_0003229 abnormal vitelline vasculature morphology anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network http://purl.obolibrary.org/obo/MP_0004077 abnormal striatum morphology http://purl.obolibrary.org/obo/MP_0006007 abnormal basal ganglion morphology any structural anomaly of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking http://purl.obolibrary.org/obo/MP_0004078 abnormal caudate nucleus morphology http://purl.obolibrary.org/obo/MP_0004102 abnormal dorsal striatum morphology any structural anomaly of one or both C-shaped structures containing input neurons involved with control of voluntary movement in the brain http://purl.obolibrary.org/obo/MP_0004079 abnormal putamen morphology http://purl.obolibrary.org/obo/MP_0004102 abnormal dorsal striatum morphology any structural anomaly of the lens-shaped basal ganglion involved with control of voluntary movement in the brain http://purl.obolibrary.org/obo/MP_0004080 abnormal nucleus accumbens morphology http://purl.obolibrary.org/obo/MP_0004166 abnormal limbic system morphology any structural anomaly of the group of neurons located at the head of the caudate nucleus and anterior to the putamen; these neurons normally are involved in sensations of pleasure and reactions to addictive substances http://purl.obolibrary.org/obo/MP_0004081 abnormal globus pallidus morphology http://purl.obolibrary.org/obo/MP_0006007 abnormal basal ganglion morphology any structural anomaly of one of the basal ganglia involved with control of voluntary movement in the brain; consists of an external and an internal segment http://purl.obolibrary.org/obo/MP_0004082 abnormal habenula morphology http://purl.obolibrary.org/obo/MP_0000840 abnormal epithalamus morphology any structural anomaly in the group of nuclei that makes up the small eminence on the dorsomedial surface of the thalamus, just in front of the dorsal commissure on the lateral edge of the habenular trigone http://purl.obolibrary.org/obo/MP_0004083 polysyndactyly http://purl.obolibrary.org/obo/MP_0000564 syndactyly greater than the normal complement of digits present on an autopod with interdigital webbing also present http://purl.obolibrary.org/obo/MP_0004084 abnormal cardiac muscle relaxation http://purl.obolibrary.org/obo/MP_0004036 abnormal muscle relaxation altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min http://purl.obolibrary.org/obo/MP_0004085 abnormal heartbeat http://purl.obolibrary.org/obo/MP_0001544 abnormal cardiovascular system physiology anomaly in the appearance of regularly spaced contractions of the heart due to defects in the frequency, rate, pattern or extent of heart contraction http://purl.obolibrary.org/obo/MP_0004086 absent heartbeat http://purl.obolibrary.org/obo/MP_0004085 abnormal heartbeat lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus) http://purl.obolibrary.org/obo/MP_0004087 abnormal muscle fiber morphology http://purl.obolibrary.org/obo/MP_0002108 abnormal muscle morphology any structural anomaly of the muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated http://purl.obolibrary.org/obo/MP_0004088 abnormal sarcoplasmic reticulum morphology http://purl.obolibrary.org/obo/MP_0004087 abnormal muscle fiber morphology any structural anomaly in the endoplasmic reticulum of skeletal and cardiac muscle, i.e. the complex of vesicles, tubules, and cisternae that form a continuous structure around striated myofibrils, with a repetition of structure within each sarcomere http://purl.obolibrary.org/obo/MP_0004089 dilated sarcoplasmic reticulum http://purl.obolibrary.org/obo/MP_0004088 abnormal sarcoplasmic reticulum morphology an expansion in the volume in the endoplasmic reticulum of skeletal and cardiac muscle, i.e. the complex of vesicles, tubules, and cisternae that form a continuous structure around striated myofibrils, with a repetition of structure within each sarcomere http://purl.obolibrary.org/obo/MP_0004090 abnormal sarcomere morphology http://purl.obolibrary.org/obo/MP_0004087 abnormal muscle fiber morphology any structural anomaly in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle http://purl.obolibrary.org/obo/MP_0004091 abnormal Z lines http://purl.obolibrary.org/obo/MP_0004087 abnormal muscle fiber morphology any structural anomaly in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere http://purl.obolibrary.org/obo/MP_0004092 absent Z lines http://purl.obolibrary.org/obo/MP_0004091 abnormal Z lines missing the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere http://purl.obolibrary.org/obo/MP_0004093 diffuse Z lines http://purl.obolibrary.org/obo/MP_0004091 abnormal Z lines widely spread cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere http://purl.obolibrary.org/obo/MP_0004094 abnormal M lines http://purl.obolibrary.org/obo/MP_0004087 abnormal muscle fiber morphology any structural anomaly of the band in the center of the H band that contains proteins that crosslink the thick filament system (myosins) and the M-band part of the elastic filaments http://purl.obolibrary.org/obo/MP_0004095 ocular distichiasis http://purl.obolibrary.org/obo/MP_0001340 abnormal eyelid morphology presence of a double row of eyelashes on an eyelid, one or both of which are turned in against the eyeball http://purl.obolibrary.org/obo/MP_0004096 abnormal midbrain-hindbrain boundary development http://purl.obolibrary.org/obo/MP_0012132 abnormal midbrain-hindbrain boundary morphology anomaly in the formation of the midbrain-hindbrain domain, comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; an organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate http://purl.obolibrary.org/obo/MP_0004097 abnormal cerebellar cortex morphology http://purl.obolibrary.org/obo/MP_0000849 abnormal cerebellum morphology any structural anomaly of the thin mantle of grey matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function http://purl.obolibrary.org/obo/MP_0004098 abnormal cerebellar granule cell morphology http://purl.obolibrary.org/obo/MP_0000886 abnormal cerebellar granule layer morphology any structural anomaly of the small neurons of the cerebellar granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites http://purl.obolibrary.org/obo/MP_0004099 abnormal cerebellar glomerulus morphology http://purl.obolibrary.org/obo/MP_0000886 abnormal cerebellar granule layer morphology any structural anomaly of an intertwined cluster of nerve fibers surrounded by glia where mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons http://purl.obolibrary.org/obo/MP_0004100 abnormal spinal cord interneuron morphology http://purl.obolibrary.org/obo/MP_0008503 abnormal spinal cord grey matter morphology any structural anomaly of neurons that exclusively interact with other neurons in the spinal cord http://purl.obolibrary.org/obo/MP_0004101 abnormal brain interneuron morphology http://purl.obolibrary.org/obo/MP_0002152 abnormal brain morphology any structural anomaly of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types http://purl.obolibrary.org/obo/MP_0004102 abnormal dorsal striatum morphology http://purl.obolibrary.org/obo/MP_0004077 abnormal striatum morphology any structural anomaly of the regions of the caudate nucleus and the putamen that lie dorsal to the anterior commissure http://purl.obolibrary.org/obo/MP_0004103 abnormal ventral striatum morphology http://purl.obolibrary.org/obo/MP_0004077 abnormal striatum morphology any structural anomaly of the regions of the nucleus accumbens and some nuclei of the olfactory tubercle that lie ventral to the anterior commissure http://purl.obolibrary.org/obo/MP_0004105 corneal abrasion http://purl.obolibrary.org/obo/MP_0001312 abnormal cornea morphology scraping away or denuding of the corneal surface http://purl.obolibrary.org/obo/MP_0004106 lymphatic vessel hyperplasia http://purl.obolibrary.org/obo/MP_0010200 enlarged lymphatic vessel overdevelopment or increased size, usually due an increased number of cells in lymphatic vessels http://purl.obolibrary.org/obo/MP_0004107 abnormal thoracic duct morphology http://purl.obolibrary.org/obo/MP_0001879 abnormal lymphatic vessel morphology any structural anomaly in the largest collecting lymph vessel in the body, beginning at the cisterna chyli at about the level of the second lumbar vertebra, and drains into the systemic (blood) circulation at the left brachiocephalic vein between the left subclavian and left internal jugular veins http://purl.obolibrary.org/obo/MP_0004108 abnormal esophageal peristalsis http://purl.obolibrary.org/obo/MP_0011082 abnormal gastrointestinal motility altered esophageal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls that move the esophagus contents forward http://purl.obolibrary.org/obo/MP_0004109 abnormal Sertoli cell development http://purl.obolibrary.org/obo/MP_0003830 abnormal testis development anomalous differentiation of cells that support germ cell differentiation in males http://purl.obolibrary.org/obo/MP_0004110 transposition of great arteries http://purl.obolibrary.org/obo/MP_0010426 abnormal heart and great artery attachment cardiovascular structural anomaly in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle http://purl.obolibrary.org/obo/MP_0004111 abnormal coronary artery morphology http://purl.obolibrary.org/obo/MP_0010551 abnormal coronary vessel morphology any structural anomaly of any of the arteries that branch from the ascending aorta to supply blood to the heart http://purl.obolibrary.org/obo/MP_0004112 abnormal arteriole morphology http://purl.obolibrary.org/obo/MP_0002191 abnormal artery morphology any structural anomaly of the small diameter vessels that branch from the arteries and lead to the capillaries http://purl.obolibrary.org/obo/MP_0004113 abnormal aortic arch morphology http://purl.obolibrary.org/obo/MP_0010468 abnormal thoracic aorta morphology any structural anomaly of the convex portion of the aorta between the ascending and descending parts of the aorta; branches from it include the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery http://purl.obolibrary.org/obo/MP_0004114 abnormal atrioventricular node morphology http://purl.obolibrary.org/obo/MP_0004123 abnormal impulse conducting system morphology any structural anomaly of the small nodular mass of specialized muscle fibers located in the interatrial septum near the opening of the coronary sinus; this node gives rise to the electrical connection between the atria and ventricles and responds to the sinoatrial node http://purl.obolibrary.org/obo/MP_0004115 abnormal sinoatrial node morphology http://purl.obolibrary.org/obo/MP_0004123 abnormal impulse conducting system morphology any structural anomaly of the small mass of modified cardiac muscle fibers located at the junction of the superior vena cava and the right atrium that is the source of contraction impulses for the heart http://purl.obolibrary.org/obo/MP_0004116 abnormal atrioventricular bundle conduction http://purl.obolibrary.org/obo/MP_0003137 abnormal impulse conducting system conduction anomaly in the transfer of cardiac electrical impulses through the specialized cardiac muscle fibers that originates in the atrioventricular node and extends into the ventricle http://purl.obolibrary.org/obo/MP_0004117 abnormal atrioventricular bundle morphology http://purl.obolibrary.org/obo/MP_0004123 abnormal impulse conducting system morphology any structural anomaly of the specialized cardiac muscle fibers that originates in the atrioventricular node and extends into the ventricle http://purl.obolibrary.org/obo/MP_0004118 abnormal baroreceptor morphology http://purl.obolibrary.org/obo/MP_0000972 abnormal mechanoreceptor morphology any structural anomaly in the sensory nerve endings in the wall of the atria of the heart, vena cava, aortic arch and carotid sinus that are sensitive to changes in blood pressure http://purl.obolibrary.org/obo/MP_0004119 hypokalemia http://purl.obolibrary.org/obo/MP_0005628 decreased circulating potassium level excessively low concentrations of potassium in the circulating blood; may be chronic or due to gastrointestinal and kidney depletion due to infection http://purl.obolibrary.org/obo/MP_0004120 cardiac ischemia http://purl.obolibrary.org/obo/MP_0006111 abnormal coronary circulation inadequate blood flow to the heart; may cause infarction and is usually caused by coronary artery disease http://purl.obolibrary.org/obo/MP_0004121 abnormal sarcolemma morphology http://purl.obolibrary.org/obo/MP_0004087 abnormal muscle fiber morphology any structural anomaly in the plasma membrane of a muscle fiber that is capable of conducting electrical impulses http://purl.obolibrary.org/obo/MP_0004122 abnormal sinus arrhythmia http://purl.obolibrary.org/obo/MP_0001629 abnormal heart rate any anomaly in the normal phenomenon of mild acceleration and slowing of the heart rate that occurs during the respiratory cycle http://purl.obolibrary.org/obo/MP_0004123 abnormal impulse conducting system morphology http://purl.obolibrary.org/obo/MP_0000266 abnormal heart morphology any structural anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart http://purl.obolibrary.org/obo/MP_0004124 abnormal Purkinje fiber morphology http://purl.obolibrary.org/obo/MP_0004123 abnormal impulse conducting system morphology any structural anomaly in the cardiac muscle fibers composing the terminal portion of the heart conduction system located in the ventricle http://purl.obolibrary.org/obo/MP_0004125 abnormal venule morphology http://purl.obolibrary.org/obo/MP_0002725 abnormal vein morphology any structural anomaly of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins http://purl.obolibrary.org/obo/MP_0004126 thin hypodermis http://purl.obolibrary.org/obo/MP_0003705 abnormal hypodermis morphology reduced thickness of the irregular layer of loose connective tissue containing fibroblasts, adipose cells, and macrophages, that is immediately deep to the skin and superficial to the deep fascia http://purl.obolibrary.org/obo/MP_0004127 thick hypodermis http://purl.obolibrary.org/obo/MP_0003705 abnormal hypodermis morphology increase in the width of the irregular layer of loose connective tissue containing fibroblasts, adipose cells, and macrophages, that is immediately deep to the skin and superficial to the deep fascia http://purl.obolibrary.org/obo/MP_0004129 abnormal respiratory quotient http://purl.obolibrary.org/obo/MP_0003948 abnormal gas homeostasis anomaly in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls http://purl.obolibrary.org/obo/MP_0004130 abnormal muscle cell glucose uptake http://purl.obolibrary.org/obo/MP_0003925 abnormal cellular glucose import anomaly in the ability of muscle cells to take in glucose http://purl.obolibrary.org/obo/MP_0004131 abnormal motile primary cilium morphology http://purl.obolibrary.org/obo/MP_0013203 abnormal primary cilium morphology any structural anomaly of the cilia of the embryo found on the cells of the embryonic node, which generate flow of extraembryonic fluid surrounding the node in a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization http://purl.obolibrary.org/obo/MP_0004132 absent embryonic cilia http://purl.obolibrary.org/obo/MP_0004131 abnormal motile primary cilium morphology absence of cilia on the cells of the embryonic node http://purl.obolibrary.org/obo/MP_0004133 heterotaxia http://purl.obolibrary.org/obo/MP_0005378 growth/size/body phenotype abnormal arrangement of organs or parts of the body in relation to each other according to the left-right axis http://purl.obolibrary.org/obo/MP_0004134 abnormal chest morphology http://purl.obolibrary.org/obo/MP_0005378 growth/size/body phenotype any structural anomaly of the part of the body between the neck and the abdomen http://purl.obolibrary.org/obo/MP_0004135 abnormal mammary gland embryonic development http://purl.obolibrary.org/obo/MP_0000628 abnormal mammary gland development aberration in the differentiation of the mammary gland during early embryogenesis http://purl.obolibrary.org/obo/MP_0004136 abnormal tongue muscle morphology http://purl.obolibrary.org/obo/MP_0000762 abnormal tongue morphology any structural anomaly of the muscular portion of the tongue http://purl.obolibrary.org/obo/MP_0004137 abnormal gastric surface mucous cell morphology http://purl.obolibrary.org/obo/MP_0010792 abnormal stomach mucosa morphology any structural anomaly of the mucus secreting epithelial cells that line the luminal surface of the stomach and the gastric pits which secrete mucus and HCO3- to protect the gastric surface from the acidic environment of the stomach http://purl.obolibrary.org/obo/MP_0004138 abnormal mucous neck cell morphology http://purl.obolibrary.org/obo/MP_0003892 abnormal gastric gland morphology any structural anomaly of the mucin-producing epithelial cells present in the neck of the gastric glands http://purl.obolibrary.org/obo/MP_0004139 abnormal gastric parietal cell morphology http://purl.obolibrary.org/obo/MP_0003892 abnormal gastric gland morphology any structural anomaly of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland http://purl.obolibrary.org/obo/MP_0004140 abnormal chief cell morphology http://purl.obolibrary.org/obo/MP_0003892 abnormal gastric gland morphology any structural anomaly of the pepsinogen producing epithelial cells that are clustered at the base of the gastric gland http://purl.obolibrary.org/obo/MP_0004141 abnormal enteroendocrine cell morphology http://purl.obolibrary.org/obo/MP_0000462 abnormal digestive system morphology any structural anomaly of the various hormone- or neurotransmitter-secreting epithelial cells present throughout the mucosa of the digestive tract http://purl.obolibrary.org/obo/MP_0004142 abnormal muscle tone http://purl.obolibrary.org/obo/MP_0002106 abnormal muscle physiology anomaly in the resting tautness or laxity of a muscle, normally somewhere in the middle of the range between total contraction and total relaxation http://purl.obolibrary.org/obo/MP_0004143 muscle hypertonia http://purl.obolibrary.org/obo/MP_0004142 abnormal muscle tone increased muscle tension resulting in stiffness of the muscles in the resting state http://purl.obolibrary.org/obo/MP_0004144 hypotonia http://purl.obolibrary.org/obo/MP_0004142 abnormal muscle tone decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness http://purl.obolibrary.org/obo/MP_0004145 abnormal muscle electrophysiology http://purl.obolibrary.org/obo/MP_0002106 abnormal muscle physiology any functional anomaly of the musculature as it relates to electrical phenomena http://purl.obolibrary.org/obo/MP_0004146 absent M lines http://purl.obolibrary.org/obo/MP_0004094 abnormal M lines missing the band in the center of the H band that contains proteins that crosslink the thick filament system (myosins) and the M-band part of the elastic filaments http://purl.obolibrary.org/obo/MP_0004147 increased porphyrin level http://purl.obolibrary.org/obo/MP_0011989 abnormal porphyrin level elevated concentration of porphyrins or protoporphyrins http://purl.obolibrary.org/obo/MP_0004148 increased compact bone thickness http://purl.obolibrary.org/obo/MP_0000134 abnormal compact bone thickness thicker than normal superficial layer of compact bone http://purl.obolibrary.org/obo/MP_0004149 increased bone strength http://purl.obolibrary.org/obo/MP_0001542 abnormal bone strength increased ability of bone to endure the application of force without yielding or breaking http://purl.obolibrary.org/obo/MP_0004150 absent caveolae http://purl.obolibrary.org/obo/MP_0003950 abnormal plasma membrane morphology absence of the small pockets, vesicles, caves, or recesses communicating with the outside of a cell and extending inward, indenting the cytoplasm and the cell membrane http://purl.obolibrary.org/obo/MP_0004151 decreased circulating iron level http://purl.obolibrary.org/obo/MP_0004152 abnormal circulating iron level less than the normal concentration of iron in the blood http://purl.obolibrary.org/obo/MP_0004152 abnormal circulating iron level http://purl.obolibrary.org/obo/MP_0006357 abnormal circulating mineral level anomalous blood concentration of the metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes http://purl.obolibrary.org/obo/MP_0004153 increased renal tubule apoptosis http://purl.obolibrary.org/obo/MP_0011368 increased kidney apoptosis increase in the number of renal tubule cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0004154 renal tubular necrosis http://purl.obolibrary.org/obo/MP_0003946 renal necrosis morphological changes resulting from pathological death of renal tubular tissue; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0004155 decreased susceptibility to induced pancreatitis http://purl.obolibrary.org/obo/MP_0002693 abnormal pancreas physiology reduced or absent inflammatory response in the pancreatic tissue after experimental manipulation http://purl.obolibrary.org/obo/MP_0004156 abnormal QT variability http://purl.obolibrary.org/obo/MP_0003899 abnormal QT interval anomaly in the index of beat-to-beat QT interval fluctuations (temporal QT interval variability), normally expressed as a unitless negative number reflecting beat-to-beat changes in ventricular repolarization; an increased, positive QTVI number indicates significant repolarization abnormalities http://purl.obolibrary.org/obo/MP_0004157 interrupted aortic arch http://purl.obolibrary.org/obo/MP_0010544 interrupted aorta complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery http://purl.obolibrary.org/obo/MP_0004158 right aortic arch http://purl.obolibrary.org/obo/MP_0004113 abnormal aortic arch morphology the aortic arch lies to the right of the trachea and esophagus; results from persistence of the entire right dorsal arch and involution of a segment of the left arch http://purl.obolibrary.org/obo/MP_0004159 double aortic arch http://purl.obolibrary.org/obo/MP_0010466 vascular ring defect in which the main aorta tube splits into large left and right branches (right and left aortic arches), encircling the trachea and esophagus, before becoming one tube to go to the lower body http://purl.obolibrary.org/obo/MP_0004160 retroesophageal right subclavian artery http://purl.obolibrary.org/obo/MP_0010465 aberrant origin of the right subclavian artery the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch http://purl.obolibrary.org/obo/MP_0004161 cervical aortic arch http://purl.obolibrary.org/obo/MP_0004113 abnormal aortic arch morphology aortic arch is located above the level of the clavicle http://purl.obolibrary.org/obo/MP_0004162 abnormal mammillary body morphology http://purl.obolibrary.org/obo/MP_0000830 abnormal diencephalon morphology any structural anomaly of the protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei http://purl.obolibrary.org/obo/MP_0004163 abnormal adenohypophysis morphology http://purl.obolibrary.org/obo/MP_0000633 abnormal pituitary gland morphology any structural anomaly of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus http://purl.obolibrary.org/obo/MP_0004164 abnormal neurohypophysis morphology http://purl.obolibrary.org/obo/MP_0000633 abnormal pituitary gland morphology any structural anomaly of the posterior part of the pituitary gland that secretes hormones involved in blood pressure regulation such as oxytocin and antidiuretic hormone http://purl.obolibrary.org/obo/MP_0004165 abnormal lateral geniculate nucleus morphology http://purl.obolibrary.org/obo/MP_0000832 abnormal thalamus morphology any structural anomaly of the group of neurons that serve as the primary processor of visual information received from the retina via the optic tract and send processed information to the visual cortex of the occipital lobe http://purl.obolibrary.org/obo/MP_0004166 abnormal limbic system morphology http://purl.obolibrary.org/obo/MP_0000783 abnormal forebrain morphology any structural anomaly of any of a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory; these structures act together to control the endocrine system and the autonomic nervous system http://purl.obolibrary.org/obo/MP_0004167 abnormal cingulate gyrus morphology http://purl.obolibrary.org/obo/MP_0004169 abnormal fornicate gyrus morphology any structural anomaly of the ridge in the cerebral cortex located dorsal to the corpus callosum that controls autonomic functions regulating heart rate and blood pressure as well as cognitive and attentional processing http://purl.obolibrary.org/obo/MP_0004168 abnormal parahippocampal gyrus morphology http://purl.obolibrary.org/obo/MP_0004169 abnormal fornicate gyrus morphology any structural anomaly of the ridge in the cerebral cortex that contains the olfactory cortex and that plays a role in the formation of topographical memory http://purl.obolibrary.org/obo/MP_0004169 abnormal fornicate gyrus morphology http://purl.obolibrary.org/obo/MP_0004166 abnormal limbic system morphology any structural anomaly of the horseshoe-shaped gyrus of the cerebral cortex that consists of the cingulate gyrus and the parahippocampal gyrus http://purl.obolibrary.org/obo/MP_0004170 abnormal orbitofrontal cortex morphology http://purl.obolibrary.org/obo/MP_0004166 abnormal limbic system morphology any structural anomaly of the region of the cerebral cortex covering the basal surface of the frontal lobes; this region normally controls emotion and decision making http://purl.obolibrary.org/obo/MP_0004171 abnormal pallium development http://purl.obolibrary.org/obo/MP_0000934 abnormal telencephalon development anomaly in the progression of the formation of the roof region of the telencephalon http://purl.obolibrary.org/obo/MP_0004172 abnormal subpallium development http://purl.obolibrary.org/obo/MP_0000934 abnormal telencephalon development anomaly in the progression of the formation of the base region of the telencephalon http://purl.obolibrary.org/obo/MP_0004173 abnormal intervertebral disk morphology http://purl.obolibrary.org/obo/MP_0004703 abnormal vertebral column morphology any structural anomaly of the cartilaginous and gelatinous structure found between vertebrae http://purl.obolibrary.org/obo/MP_0004174 abnormal spine curvature http://purl.obolibrary.org/obo/MP_0004703 abnormal vertebral column morphology deviation from the typical S-shape of the spine http://purl.obolibrary.org/obo/MP_0004175 telangiectases http://purl.obolibrary.org/obo/MP_0001613 abnormal vasodilation vascular lesion formed by dilation of a group of small blood vessels http://purl.obolibrary.org/obo/MP_0004176 ear telangiectases http://purl.obolibrary.org/obo/MP_0004175 telangiectases vascular lesion formed by dilation of a group of small blood vessels in the ear http://purl.obolibrary.org/obo/MP_0004177 tail telangiectases http://purl.obolibrary.org/obo/MP_0004175 telangiectases vascular lesion formed by dilation of a group of small blood vessels in the tail http://purl.obolibrary.org/obo/MP_0004178 neck telangiectases http://purl.obolibrary.org/obo/MP_0004175 telangiectases vascular lesion formed by dilation of a group of small blood vessels in the neck http://purl.obolibrary.org/obo/MP_0004179 transmission ratio distortion http://purl.obolibrary.org/obo/MP_0001929 abnormal gametogenesis the frequency that an allele or haplotype in the offspring of an organism deviates from expected Mendelian ratios http://purl.obolibrary.org/obo/MP_0004180 failure of initiation of embryo turning http://purl.obolibrary.org/obo/MP_0001700 abnormal embryo turning failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage http://purl.obolibrary.org/obo/MP_0004181 abnormal carotid artery morphology http://purl.obolibrary.org/obo/MP_0011655 abnormal systemic artery morphology any structural anomaly of the bilaterally paired branched arteries that deliver oxygenated nutrient filled blood from the heart to the head, neck, and brain; of the two common carotid arteries, which extend headward on each side of the anterior neck, the left originates in the arch of the aorta over the heart; the right originates in the brachiocephalic trunk, the largest branch from the arch of the aorta; each common carotid artery divides into an external and an internal carotid artery near the top of the thyroid http://purl.obolibrary.org/obo/MP_0004182 abnormal spermiation http://purl.obolibrary.org/obo/MP_0001932 abnormal spermiogenesis anomaly in the process by which mature spermatozoa release from supporting Sertoli cells into the lumen of seminiferous tubules http://purl.obolibrary.org/obo/MP_0004183 abnormal sympathetic nervous system physiology http://purl.obolibrary.org/obo/MP_0006276 abnormal autonomic nervous system physiology any functional anomaly of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body's response to stressful situations http://purl.obolibrary.org/obo/MP_0004184 abnormal baroreceptor physiology http://purl.obolibrary.org/obo/MP_0004183 abnormal sympathetic nervous system physiology any functional anomaly of the sensory nerve endings found in the wall of the atria of the heart, vena cava, aortic arch and carotid sinus that are sensitive to changes in blood pressure http://purl.obolibrary.org/obo/MP_0004185 abnormal adipocyte glucose uptake http://purl.obolibrary.org/obo/MP_0005666 abnormal adipose tissue physiology anomaly in the ability of adipocytes to take in glucose http://purl.obolibrary.org/obo/MP_0004186 abnormal area postrema morphology http://purl.obolibrary.org/obo/MP_0000828 abnormal fourth ventricle morphology any structural anomaly of the small, elevated area in the lateral wall of the inferior recess of the fourth ventricle, involved in the control of cardiorespiratory physiology http://purl.obolibrary.org/obo/MP_0004187 cardia bifida http://purl.obolibrary.org/obo/MP_0000270 abnormal heart tube morphology failure of the bilateral myocardial cells to coalesce into a single central heart tube resulting in the presence of two independent hearts http://purl.obolibrary.org/obo/MP_0004188 delayed embryo turning http://purl.obolibrary.org/obo/MP_0001700 abnormal embryo turning completion of axial rotation occurs later than in controls but is eventually completed http://purl.obolibrary.org/obo/MP_0004189 abnormal alveolar process morphology http://purl.obolibrary.org/obo/MP_0000454 abnormal jaw morphology any structural anomaly of the thickened ridge of bone in the mandible and maxilla that holds the tooth sockets http://purl.obolibrary.org/obo/MP_0004190 abnormal direction of embryo turning http://purl.obolibrary.org/obo/MP_0001700 abnormal embryo turning axial rotation of the embryo in a direction other than the normal anticlockwise direction when viewed towards the caudal pole during the late primitive streak/early somite stage; clockwise rotation is frequently associated with heart and visceral defects http://purl.obolibrary.org/obo/MP_0004191 neuronal intranuclear inclusions http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology presence of aggregates of protein within the nuclei of neurons; frequently seen in Huntington's disease http://purl.obolibrary.org/obo/MP_0004192 abnormal kidney pyramid morphology http://purl.obolibrary.org/obo/MP_0003014 abnormal kidney medulla morphology any structural anomaly of the conical mass of tissue, containing part of the secreting and collecting tubules, whose base faces the renal cortex http://purl.obolibrary.org/obo/MP_0004193 abnormal kidney papilla morphology http://purl.obolibrary.org/obo/MP_0004194 abnormal kidney pelvis morphology any structural anomaly of the apex of the renal pyramid that projects into a calyx http://purl.obolibrary.org/obo/MP_0004194 abnormal kidney pelvis morphology http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology any structural anomaly of the funnel shaped proximal portion of the ureter that is formed by convergence of the major calices http://purl.obolibrary.org/obo/MP_0004195 abnormal kidney calyx morphology http://purl.obolibrary.org/obo/MP_0004194 abnormal kidney pelvis morphology any structural anomaly of any of the branches of the renal pelvis that surround each renal papilla and collect urine http://purl.obolibrary.org/obo/MP_0004196 abnormal prenatal growth/weight/body size http://purl.obolibrary.org/obo/MP_0005378 growth/size/body phenotype limited or accelerated growth or development apparent before birth http://purl.obolibrary.org/obo/MP_0004197 abnormal fetal growth/weight/body size http://purl.obolibrary.org/obo/MP_0004196 abnormal prenatal growth/weight/body size limited or accelerated growth or development apparent during the fetal period (sensu Mus: from E14 through birth) http://purl.obolibrary.org/obo/MP_0004198 abnormal fetal size http://purl.obolibrary.org/obo/MP_0010866 abnormal prenatal body size anomalous proportions of a fetus compared to littermates (sensu Mus: from E14 through birth) http://purl.obolibrary.org/obo/MP_0004199 increased fetal size http://purl.obolibrary.org/obo/MP_0004198 abnormal fetal size larger proportions of a fetus compared to littermates (sensu Mus: from E14 through birth) http://purl.obolibrary.org/obo/MP_0004200 decreased fetal size http://purl.obolibrary.org/obo/MP_0004198 abnormal fetal size smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth) http://purl.obolibrary.org/obo/MP_0004201 fetal growth retardation http://purl.obolibrary.org/obo/MP_0010865 prenatal growth retardation slow or limited development during the fetal period (sensu Mus: from E14 through birth) http://purl.obolibrary.org/obo/MP_0004202 pulmonary hyperplasia http://purl.obolibrary.org/obo/MP_0004882 enlarged lung overdevelopment or increased size, usually due an increased number of cells of the respiratory organ in all or part of the organ http://purl.obolibrary.org/obo/MP_0004203 abnormal cranial flexure morphology http://purl.obolibrary.org/obo/MP_0003864 abnormal midbrain development any structural anomaly or absence of the sharp, ventrally concave bend in the developing midbrain of the embryo http://purl.obolibrary.org/obo/MP_0004204 absent stapes http://purl.obolibrary.org/obo/MP_0005107 abnormal stapes morphology absence of the smallest and innermost of the three auditory ossicles http://purl.obolibrary.org/obo/MP_0004205 absent hyoid bone http://purl.obolibrary.org/obo/MP_0003056 abnormal hyoid bone morphology absence of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles http://purl.obolibrary.org/obo/MP_0004206 abnormal dermomyotome development http://purl.obolibrary.org/obo/MP_0000737 abnormal myotome development any structural anomaly of the portion of the embryonic somite that remains after migration of the sclerotomic tissue http://purl.obolibrary.org/obo/MP_0004207 increased squamous cell carcinoma incidence http://purl.obolibrary.org/obo/MP_0002038 increased carcinoma incidence higher than normal incidence of a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix http://purl.obolibrary.org/obo/MP_0004208 increased basal cell carcinoma incidence http://purl.obolibrary.org/obo/MP_0010300 increased skin tumor incidence greater than the expected number of a slow-growing, invasive, but usually non-metastasizing neoplasm that originates from basal keratinocytes in the epidermis, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0004209 abnormal sweet taste sensitivity http://purl.obolibrary.org/obo/MP_0001986 abnormal taste sensitivity changes in the ability to perceive a particular flavor or suggestion of something sweet by the chemoreceptors of the gustatory system http://purl.obolibrary.org/obo/MP_0004210 abnormal bitter taste sensitivity http://purl.obolibrary.org/obo/MP_0001986 abnormal taste sensitivity changes in the ability to perceive a particular flavor or suggestion of something bitter by the chemoreceptors of the gustatory system http://purl.obolibrary.org/obo/MP_0004211 abnormal sour taste sensitivity http://purl.obolibrary.org/obo/MP_0001986 abnormal taste sensitivity changes in the ability to perceive a particular flavor or suggestion of something sour by the chemoreceptors of the gustatory system http://purl.obolibrary.org/obo/MP_0004212 abnormal salty taste sensitivity http://purl.obolibrary.org/obo/MP_0001986 abnormal taste sensitivity changes in the ability to perceive a particular flavor or suggestion of something salty by the chemoreceptors of the gustatory system http://purl.obolibrary.org/obo/MP_0004213 abnormal umami taste sensitivity http://purl.obolibrary.org/obo/MP_0001986 abnormal taste sensitivity changes in the ability to perceive a particular flavor or suggestion of something umami (savory) by the chemoreceptors of the gustatory system http://purl.obolibrary.org/obo/MP_0004214 abnormal long bone diaphysis morphology http://purl.obolibrary.org/obo/MP_0003723 abnormal long bone morphology any structural anomaly of the main or mid section (shaft) of a long bone http://purl.obolibrary.org/obo/MP_0004215 abnormal myocardial fiber physiology http://purl.obolibrary.org/obo/MP_0001544 abnormal cardiovascular system physiology anomaly in the function of the terminally differentiated, non-proliferative, multinucleated muscle cells of the heart http://purl.obolibrary.org/obo/MP_0004216 salt-resistant hypertension http://purl.obolibrary.org/obo/MP_0000231 hypertension sustained high blood pressure that is maintained regardless of the amount of salt consumed in the diet http://purl.obolibrary.org/obo/MP_0004217 salt-sensitive hypertension http://purl.obolibrary.org/obo/MP_0000231 hypertension sustained high blood pressure that is maintained with a normal or increase in the amount of salt consumed in the diet; blood pressure may return to normotensive with a low salt diet http://purl.obolibrary.org/obo/MP_0004218 meiotic nondisjunction during M1 phase http://purl.obolibrary.org/obo/MP_0009566 meiotic nondisjunction abnormal separation of pairs of homologous chromosomes during anaphase of the first meiotic division such that each daughter cell receives one set of paired chromosomes http://purl.obolibrary.org/obo/MP_0004219 meiotic nondisjunction during M2 phase http://purl.obolibrary.org/obo/MP_0009566 meiotic nondisjunction abnormal separation of chromosomes during anaphase of the second meiotic division such that one complete chromosome goes to each daughter cell http://purl.obolibrary.org/obo/MP_0004220 abnormal peripheral nervous system regeneration http://purl.obolibrary.org/obo/MP_0004858 abnormal nervous system regeneration changes in the ability or inability of healthy peripheral nervous system tissue to regenerate following injury or disease http://purl.obolibrary.org/obo/MP_0004221 abnormal iridocorneal angle http://purl.obolibrary.org/obo/MP_0005198 abnormal aqueous drainage system morphology any structural anomaly of the acute angle occurring between the iris and the cornea at the periphery of the anterior chamber of the eye http://purl.obolibrary.org/obo/MP_0004222 iris synechia http://purl.obolibrary.org/obo/MP_0001322 abnormal iris morphology an adhesion (synechia) of the iris to the cornea or lens of the eye that may develop from glaucoma, cataracts, uveitis, or keratitis or as a complication of surgery or trauma to the eye; synechiae may prevent or impede flow of aqueous fluid between the anterior and posterior chambers of the eye, resulting in angle closure glaucoma http://purl.obolibrary.org/obo/MP_0004223 hypoplastic trabecular meshwork http://purl.obolibrary.org/obo/MP_0005203 abnormal trabecular meshwork morphology reduced size of the pore-like structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates http://purl.obolibrary.org/obo/MP_0004224 absent trabecular meshwork http://purl.obolibrary.org/obo/MP_0005203 abnormal trabecular meshwork morphology absence of the pore-like structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates http://purl.obolibrary.org/obo/MP_0004225 patent foramen ovale http://purl.obolibrary.org/obo/MP_0000282 abnormal interatrial septum morphology incomplete closure of the atrial septum after birth, resulting in a flap or a valve-like opening in the atrial septal wall http://purl.obolibrary.org/obo/MP_0004226 absent Schlemm's canal http://purl.obolibrary.org/obo/MP_0005204 abnormal canal of Schlemm morphology absence of the vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation http://purl.obolibrary.org/obo/MP_0004227 increased cellular sensitivity to ionizing radiation http://purl.obolibrary.org/obo/MP_0008943 increased sensitivity to induced cell death increased incidence of cell death following exposure to ionizing radiation http://purl.obolibrary.org/obo/MP_0004228 decreased cellular sensitivity to ionizing radiation http://purl.obolibrary.org/obo/MP_0008944 decreased sensitivity to induced cell death decreased incidence of cell death following exposure to ionizing radiation http://purl.obolibrary.org/obo/MP_0004229 abnormal embryonic erythropoiesis http://purl.obolibrary.org/obo/MP_0003396 abnormal embryonic hematopoiesis anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans http://purl.obolibrary.org/obo/MP_0004230 abnormal embryonic erythrocyte morphology http://purl.obolibrary.org/obo/MP_0004229 abnormal embryonic erythropoiesis any structural anomaly of the embryonic blood cells that carry oxygen; embryonic erythrocytes arise from yolk sac blood islands and express different types of hemoglobins (beta-H1, gamma-1 and zeta) than adult erythrocytes, and can enucleate in circulation http://purl.obolibrary.org/obo/MP_0004231 abnormal calcium ion homeostasis http://purl.obolibrary.org/obo/MP_0001765 abnormal ion homeostasis anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment http://purl.obolibrary.org/obo/MP_0004232 decreased muscle weight http://purl.obolibrary.org/obo/MP_0004233 abnormal muscle weight less than average muscle weight http://purl.obolibrary.org/obo/MP_0004233 abnormal muscle weight http://purl.obolibrary.org/obo/MP_0002108 abnormal muscle morphology any anomaly in the average muscle weight http://purl.obolibrary.org/obo/MP_0004234 abnormal masticatory muscle morphology http://purl.obolibrary.org/obo/MP_0000759 abnormal skeletal muscle morphology any structural anomaly of any of the muscles responsible for the movement of the jaws during mastication, including the masseter, temporal, and medial and lateral pterygoid muscles http://purl.obolibrary.org/obo/MP_0004235 abnormal masseter muscle morphology http://purl.obolibrary.org/obo/MP_0004234 abnormal masticatory muscle morphology any structural anomaly of the masticatory muscle of posterior cheek with origin from the inferior border and medial surface of the zygomatic arch, with insertion into the lateral surface of the ramus of the mandible, with nerve supply from the masseteric nerve, and whose action closes the jaw during chewing http://purl.obolibrary.org/obo/MP_0004236 absent masseter muscle http://purl.obolibrary.org/obo/MP_0004235 abnormal masseter muscle morphology absence of the masticatory muscle of posterior cheek http://purl.obolibrary.org/obo/MP_0004237 abnormal pterygoid muscle morphology http://purl.obolibrary.org/obo/MP_0004234 abnormal masticatory muscle morphology any structural anomaly of the muscles descending from the sphenoid bone to the lower jaw including the internal, or medial, pterygoid muscle and external, or lateral, pterygoid muscle; the action of the former is closing the jaws and that of the latter is opening the jaws, protruding the mandible, and moving the mandible from side to side http://purl.obolibrary.org/obo/MP_0004238 absent pterygoid muscle http://purl.obolibrary.org/obo/MP_0004237 abnormal pterygoid muscle morphology absence of either the internal or external or of both pterygoid muscles http://purl.obolibrary.org/obo/MP_0004239 abnormal temporalis muscle morphology http://purl.obolibrary.org/obo/MP_0004234 abnormal masticatory muscle morphology any structural anomaly of the superior-most masticatory muscle whose action is closing the jaws; its posterior portion retracts the mandible http://purl.obolibrary.org/obo/MP_0004240 absent temporalis muscle http://purl.obolibrary.org/obo/MP_0004239 abnormal temporalis muscle morphology absence of the superior-most masticatory muscle whose action is closing the jaws; its posterior portion retracts the mandible http://purl.obolibrary.org/obo/MP_0004241 acantholysis http://purl.obolibrary.org/obo/MP_0001236 abnormal epidermis stratum spinosum morphology separation of prickle cells of the spinous layer of the epidermis, resulting in atrophy of the prickle cell layer, as in conditions such as pemphigus vulgaris and Darier disease http://purl.obolibrary.org/obo/MP_0004242 abnormal plasmacytoid dendritic cell morphology http://purl.obolibrary.org/obo/MP_0005461 abnormal dendritic cell morphology any structural anomaly of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli; plasmacytoid dendritic cells are found in the thymic medulla and lymph node T cell areas and are responsible for immune tolerance http://purl.obolibrary.org/obo/MP_0004243 abnormal motor nerve collateral sprouting http://purl.obolibrary.org/obo/MP_0010726 abnormal collateral sprouting aberrant response of a motor neuron to form new neuritic processes (sprouts) that emerge from the nodes of Ranvier or terminal arborizations in response to nerve injury (such as denervation), application of nerve toxin, or muscle inactivity (usually due to disease) http://purl.obolibrary.org/obo/MP_0004244 abnormal miscarriage rate http://purl.obolibrary.org/obo/MP_0003699 abnormal female reproductive system physiology change in frequency of a natural or accidental termination of a pregnancy at a stage where the embryo or the fetus is incapable of surviving independently of the mother http://purl.obolibrary.org/obo/MP_0004245 genital hemorrhage http://purl.obolibrary.org/obo/MP_0001919 abnormal reproductive system physiology bleeding into the genitals http://purl.obolibrary.org/obo/MP_0004246 abnormal extensor digitorum longus morphology http://purl.obolibrary.org/obo/MP_0003358 abnormal hypaxial muscle morphology any structural anomaly of the penniform muscle of the lateral front part of the leg responsible for extension of the toes and dorsiflexion of the ankle http://purl.obolibrary.org/obo/MP_0004247 small pancreas http://purl.obolibrary.org/obo/MP_0009106 abnormal pancreas size decrease of the size of the pancreas compared to controls http://purl.obolibrary.org/obo/MP_0004248 abnormal epaxial muscle morphology http://purl.obolibrary.org/obo/MP_0000759 abnormal skeletal muscle morphology any structural anomaly of the muscles derived from the medial myotome; includes the intrinsic back muscles http://purl.obolibrary.org/obo/MP_0004249 abnormal crista ampullaris morphology http://purl.obolibrary.org/obo/MP_0008488 abnormal semicircular canal ampulla morphology any structural anomaly in the elevation found on the inner surface of the ampullae of each semicircular duct; filaments of the vestibular nerve pass through the crista to reach hair cells on its surface; the hair cells are capped by the cupula, a gelatinous protein-polysaccharide mass http://purl.obolibrary.org/obo/MP_0004250 tau protein deposits http://purl.obolibrary.org/obo/MP_0002152 abnormal brain morphology formation of self-assembled tangles of paired helical filaments and straight filaments due to hyperphosphorylation of the tau protein; often seen in neuronal tissues of individuals with neurodegenerative disorders http://purl.obolibrary.org/obo/MP_0004251 failure of heart looping http://purl.obolibrary.org/obo/MP_0000269 abnormal heart looping failure of the primitive heart tube to loop asymmetrically during early development http://purl.obolibrary.org/obo/MP_0004252 abnormal direction of heart looping http://purl.obolibrary.org/obo/MP_0000269 abnormal heart looping deviation from the characteristic rightward direction of looping of the primitive heart tube; frequently seen in heterotaxy syndromes http://purl.obolibrary.org/obo/MP_0004253 bifid atrial appendage http://purl.obolibrary.org/obo/MP_0010489 abnormal heart atrium auricular region morphology a cardiac anomaly whereby the left or right atrial appendage is cleaved, forming two separate pouches connected by a thin strand of muscular tissue http://purl.obolibrary.org/obo/MP_0004254 cerebral amyloid angiopathy http://purl.obolibrary.org/obo/MP_0002152 abnormal brain morphology a pathological condition where there is a deposition of amyloid in the walls of the small cerebral vessels which supply the brain; this results in an increased risk of infarcts and/or intracerebral hemorrhage, possibly resulting in dementia http://purl.obolibrary.org/obo/MP_0004255 abnormal spongiotrophoblast layer morphology http://purl.obolibrary.org/obo/MP_0008957 abnormal placenta junctional zone morphology any structural anomaly of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors http://purl.obolibrary.org/obo/MP_0004256 abnormal maternal decidual layer morphology http://purl.obolibrary.org/obo/MP_0001711 abnormal placenta morphology any structural anomaly of the maternal uterine-derived portion of the placenta http://purl.obolibrary.org/obo/MP_0004257 abnormal placenta weight http://purl.obolibrary.org/obo/MP_0004258 abnormal placenta size any change in the weight of the organ of metabolic interchange between fetus and mother http://purl.obolibrary.org/obo/MP_0004258 abnormal placenta size http://purl.obolibrary.org/obo/MP_0001711 abnormal placenta morphology anomaly in the size or shape of the organ of metabolic interchange between fetus and mother http://purl.obolibrary.org/obo/MP_0004259 small placenta http://purl.obolibrary.org/obo/MP_0004258 abnormal placenta size reduced size of the size or shape of the organ of metabolic interchange between fetus and mother http://purl.obolibrary.org/obo/MP_0004260 enlarged placenta http://purl.obolibrary.org/obo/MP_0004258 abnormal placenta size increased size of the size or shape of the organ of metabolic interchange between fetus and mother http://purl.obolibrary.org/obo/MP_0004261 abnormal embryonic neuroepithelium morphology http://purl.obolibrary.org/obo/MP_0002151 abnormal neural tube morphology/development any structural anomaly of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells http://purl.obolibrary.org/obo/MP_0004262 abnormal physical strength http://purl.obolibrary.org/obo/MP_0002066 abnormal motor capabilities/coordination/movement altered ability of an organism to exert force on physical objects or of the body to support its load http://purl.obolibrary.org/obo/MP_0004263 abnormal limb posture http://purl.obolibrary.org/obo/MP_0001504 abnormal posture atypical intentionally or habitually assumed position of the limbs compared to the normal carriage of the body http://purl.obolibrary.org/obo/MP_0004264 abnormal extraembryonic tissue physiology http://purl.obolibrary.org/obo/MP_0001672 abnormal embryogenesis/ development any functional anomaly of the membranes involved with embryonic protection and nutrition http://purl.obolibrary.org/obo/MP_0004265 abnormal placental transport http://purl.obolibrary.org/obo/MP_0010038 abnormal placenta physiology anomaly in the conveyance of metabolic products and nutrients across the placenta http://purl.obolibrary.org/obo/MP_0004266 pale placenta http://purl.obolibrary.org/obo/MP_0001711 abnormal placenta morphology placenta lacking normal reddish coloration, often refers to bloodless condition http://purl.obolibrary.org/obo/MP_0004267 abnormal optic tract morphology http://purl.obolibrary.org/obo/MP_0008026 abnormal brain white matter morphology any structural anomaly of the paired bands of optic nerve fibers running from the optic chiasma mostly to the lateral geniculate body, with a smaller number of fibers terminating in the superior colliculus and the pretectal region http://purl.obolibrary.org/obo/MP_0004268 abnormal optic stalk morphology http://purl.obolibrary.org/obo/MP_0001286 abnormal eye development any structural anomaly of the narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain http://purl.obolibrary.org/obo/MP_0004269 abnormal optic cup morphology http://purl.obolibrary.org/obo/MP_0001286 abnormal eye development any structural anomaly of double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye http://purl.obolibrary.org/obo/MP_0004270 analgesia http://purl.obolibrary.org/obo/MP_0001968 abnormal touch/ nociception inability to sense pain http://purl.obolibrary.org/obo/MP_0004272 abnormal basement membrane morphology http://purl.obolibrary.org/obo/MP_0013258 abnormal extracellular matrix morphology anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis http://purl.obolibrary.org/obo/MP_0004273 abnormal basal lamina morphology http://purl.obolibrary.org/obo/MP_0004272 abnormal basement membrane morphology any structural anomaly of the sheet of extracellular matrix characteristically situated under epithelial cells, around muscles, nerves, capillaries, and fat cells, and situated between these elements and the underlying or surrounding connective tissue http://purl.obolibrary.org/obo/MP_0004274 abnormal embryonic/fetal subventricular zone morphology http://purl.obolibrary.org/obo/MP_0003861 abnormal nervous system development any structural anomaly of the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles http://purl.obolibrary.org/obo/MP_0004275 abnormal postnatal subventricular zone morphology http://purl.obolibrary.org/obo/MP_0002152 abnormal brain morphology any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells http://purl.obolibrary.org/obo/MP_0004276 abnormal medial ganglionic eminence morphology http://purl.obolibrary.org/obo/MP_0004274 abnormal embryonic/fetal subventricular zone morphology any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the neocortex; however, hippocampal neurons, thalamus, septum and olfactory bulb neurons are also partly derived from the MGE http://purl.obolibrary.org/obo/MP_0004277 abnormal lateral ganglionic eminence morphology http://purl.obolibrary.org/obo/MP_0004274 abnormal embryonic/fetal subventricular zone morphology any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the striatum; however, neocortex, thalamus, septum and olfactory bulb neurons are also partly derived from the LGE http://purl.obolibrary.org/obo/MP_0004278 abnormal caudal ganglionic eminence morphology http://purl.obolibrary.org/obo/MP_0004274 abnormal embryonic/fetal subventricular zone morphology any structural anomaly of the caudally located, distinct elevation of a transient proliferating cell mass of the fetal subventricular zone, located adjacent to the lateral ventricle http://purl.obolibrary.org/obo/MP_0004279 abnormal rostral migratory stream morphology http://purl.obolibrary.org/obo/MP_0002739 abnormal olfactory bulb development any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs http://purl.obolibrary.org/obo/MP_0004280 abnormal oculomotor nucleus morphology http://purl.obolibrary.org/obo/MP_0000897 abnormal midbrain morphology any structural anomaly of the group of motor neurons in the floor of the midbrain that gives rise to motor fibers of the oculomotor nerve http://purl.obolibrary.org/obo/MP_0004281 abnormal hypoglossal nucleus morphology http://purl.obolibrary.org/obo/MP_0000846 abnormal medulla oblongata morphology any structural anomaly of the group of motor neurons throughout most of the length of the medulla oblongata that give rise to the motor fibers of the hypoglossal nerve http://purl.obolibrary.org/obo/MP_0004282 retrognathia http://purl.obolibrary.org/obo/MP_0000454 abnormal jaw morphology abnormal posterior-shifted positioning of the jaws, particularly the mandible, relative to the facial skeleton and soft tissues http://purl.obolibrary.org/obo/MP_0004283 absent corneal endothelium http://purl.obolibrary.org/obo/MP_0005301 abnormal corneal endothelium morphology absence of the single layer of large flattened cells that cover the surface of the cornea http://purl.obolibrary.org/obo/MP_0004284 abnormal Descemet membrane http://purl.obolibrary.org/obo/MP_0001312 abnormal cornea morphology any structural anomaly in the transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea, considered to be a highly developed basement membrane http://purl.obolibrary.org/obo/MP_0004285 absent Descemet membrane http://purl.obolibrary.org/obo/MP_0004284 abnormal Descemet membrane absence of the transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea http://purl.obolibrary.org/obo/MP_0004286 abnormal internal auditory canal morphology http://purl.obolibrary.org/obo/MP_0000026 abnormal inner ear morphology any structural anomaly in the canal beginning at the opening of the internal acoustic meatus in the posterior cranial fossa, passing laterally through the petrous portion of the temporal bone to end at the fundus, where a thin plate of bone separates it from the vestibule; it gives passage to the facial and vestibulocochlear nerves together with the labyrinthine artery and veins http://purl.obolibrary.org/obo/MP_0004287 abnormal spiral limbus morphology http://purl.obolibrary.org/obo/MP_0000031 abnormal cochlea morphology any structural anomaly in the border of the spiral lamina, i.e. the thickened periosteum covering the upper plate of the bony spiral lamina of the cochlea http://purl.obolibrary.org/obo/MP_0004288 abnormal spiral ligament morphology http://purl.obolibrary.org/obo/MP_0005504 abnormal ligament morphology any structural anomaly in the thickened periosteal lining of the bony cochlea that forms the outer wall of the cochlear duct to which the basal lamina attaches http://purl.obolibrary.org/obo/MP_0004289 abnormal bony labyrinth http://purl.obolibrary.org/obo/MP_0000026 abnormal inner ear morphology any structural anomaly in the series of cavities (cochlea, vestibule, and semicircular canals) contained within the otic capsule of the petrous portion of the temporal bone; the bony labyrinth is filled with perilymph, in which the delicate, endolymph-filled membranous labyrinth is suspended http://purl.obolibrary.org/obo/MP_0004290 abnormal stapes footplate morphology http://purl.obolibrary.org/obo/MP_0005107 abnormal stapes morphology any structural anomaly in the flat portion of the stapes that fits in the oval window http://purl.obolibrary.org/obo/MP_0004292 abnormal spiral ligament fibrocyte morphology http://purl.obolibrary.org/obo/MP_0004288 abnormal spiral ligament morphology any structural anomaly in the four types of fibrocytes (types I, II , III and IV) that constitute the spiral ligament http://purl.obolibrary.org/obo/MP_0004293 abnormal type I spiral ligament fibrocytes http://purl.obolibrary.org/obo/MP_0004292 abnormal spiral ligament fibrocyte morphology any structural anomaly of type I spiral ligament fibrocytes which occupy the region beneath the stria vascularis http://purl.obolibrary.org/obo/MP_0004294 abnormal type II spiral ligament fibrocytes http://purl.obolibrary.org/obo/MP_0004292 abnormal spiral ligament fibrocyte morphology any structural anomaly of type II spiral ligament fibrocytes found in the suprastrial zone and the central area of the spiral ligament beneath the spiral prominence http://purl.obolibrary.org/obo/MP_0004295 abnormal type III spiral ligament fibrocytes http://purl.obolibrary.org/obo/MP_0004292 abnormal spiral ligament fibrocyte morphology any structural anomaly of type III spiral ligament fibrocytes which form a cell layer attached to the otic capsule http://purl.obolibrary.org/obo/MP_0004296 abnormal type IV spiral ligament fibrocytes http://purl.obolibrary.org/obo/MP_0004292 abnormal spiral ligament fibrocyte morphology any structural anomaly of type IV spiral ligament fibrocytes found in the triangular space inferior to the basilar crest http://purl.obolibrary.org/obo/MP_0004297 abnormal proprioceptive neuron morphology http://purl.obolibrary.org/obo/MP_0000965 abnormal sensory neuron morphology any structural anomaly of the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord http://purl.obolibrary.org/obo/MP_0004298 vestibular ganglion degeneration http://purl.obolibrary.org/obo/MP_0002856 abnormal vestibular ganglion morphology loss of the group of bipolar sensory nerve cell bodies concerned with equilibration that form a swelling on the vestibular part of the eighth cranial nerve in the fundus of the internal acoustic meatus http://purl.obolibrary.org/obo/MP_0004299 absent vestibular ganglion http://purl.obolibrary.org/obo/MP_0002856 abnormal vestibular ganglion morphology absence of the group of bipolar sensory nerve cell bodies concerned with equilibration that form a swelling on the vestibular part of the eighth cranial nerve in the fundus of the internal acoustic meatus http://purl.obolibrary.org/obo/MP_0004300 abnormal organ of Corti supporting cell morphology http://purl.obolibrary.org/obo/MP_0000042 abnormal organ of Corti morphology any structural anomaly in the highly differentiated epithelial cells with distinctive morphological features surrounding the hair cells in the organ of Corti; inner hair cells (IHCs) are normally surrounded by (inner and outer) phalangeal cells while OHCs are in contact with Deiters and pillar cells; Hensen cells are positioned further laterally in the organ of Corti http://purl.obolibrary.org/obo/MP_0004301 absent organ of Corti supporting cells http://purl.obolibrary.org/obo/MP_0004497 decreased organ of Corti supporting cell number absence of the highly differentiated epithelial cells with distinctive morphological features that surround all hair cells in the organ of Corti http://purl.obolibrary.org/obo/MP_0004302 abnormal Deiters cell morphology http://purl.obolibrary.org/obo/MP_0004300 abnormal organ of Corti supporting cell morphology any structural anomaly in the supporting cells of the spiral organ which are attached to the basement membrane and receive the hair cells between their free extremities http://purl.obolibrary.org/obo/MP_0004303 abnormal Hensen cell morphology http://purl.obolibrary.org/obo/MP_0004300 abnormal organ of Corti supporting cell morphology any structural anomaly in the supporting cells that form the lateral border of the organ of Corti, immediately to the outer side of Deiters' cells http://purl.obolibrary.org/obo/MP_0004304 absent spiral limbus http://purl.obolibrary.org/obo/MP_0004287 abnormal spiral limbus morphology absence of the border of the spiral lamina, i.e. the thickened periosteum covering the upper plate of the bony spiral lamina of the cochlea http://purl.obolibrary.org/obo/MP_0004305 abnormal Rosenthal canal morphology http://purl.obolibrary.org/obo/MP_0002729 abnormal inner ear canal morphology any structural anomaly in the winding tube of the bony labyrinth that makes two and a half turns about the modiolus of the cochlea; it is divided incompletely into two compartments by a winding shelf of bone, the bony spiral lamina http://purl.obolibrary.org/obo/MP_0004306 small Rosenthal canal http://purl.obolibrary.org/obo/MP_0004305 abnormal Rosenthal canal morphology reduced size of the winding tube of the bony labyrinth that makes two and a half turns about the modiolus of the cochlea http://purl.obolibrary.org/obo/MP_0004307 absent Rosenthal canal http://purl.obolibrary.org/obo/MP_0004305 abnormal Rosenthal canal morphology absence of the winding tube of the bony labyrinth that makes two and a half turns about the modiolus of the cochlea http://purl.obolibrary.org/obo/MP_0004308 abnormal basilar membrane morphology http://purl.obolibrary.org/obo/MP_0000031 abnormal cochlea morphology any structural anomaly in the membrane extending from the bony spiral membrane to the basilar crest of the cochlea; it forms the greater part of the floor of the cochlear duct separating the latter from the scala tympani, and it supports the organ of Corti http://purl.obolibrary.org/obo/MP_0004309 absent otic vesicle http://purl.obolibrary.org/obo/MP_0009806 abnormal otic vesicle morphology absence of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear http://purl.obolibrary.org/obo/MP_0004310 small otic vesicle http://purl.obolibrary.org/obo/MP_0009806 abnormal otic vesicle morphology reduced size of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear http://purl.obolibrary.org/obo/MP_0004311 otic vesicle hypoplasia http://purl.obolibrary.org/obo/MP_0004310 small otic vesicle underdevelopment of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear, usually due to a reduction in cell number http://purl.obolibrary.org/obo/MP_0004312 absent pillar cells http://purl.obolibrary.org/obo/MP_0003825 abnormal pillar cell morphology absence of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti http://purl.obolibrary.org/obo/MP_0004313 absent vestibulocochlear ganglion http://purl.obolibrary.org/obo/MP_0003703 abnormal vestibulocochlear ganglion morphology absence of the group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia http://purl.obolibrary.org/obo/MP_0004314 absent inner ear vestibule http://purl.obolibrary.org/obo/MP_0000034 abnormal inner ear vestibule morphology absence of the cavity between the semicircular canals and the cochlea of the inner ear http://purl.obolibrary.org/obo/MP_0004315 absent vestibular saccule http://purl.obolibrary.org/obo/MP_0006089 abnormal vestibular saccule morphology absence of the smaller of the two sacs in the vestibule http://purl.obolibrary.org/obo/MP_0004316 enlarged vestibular saccule http://purl.obolibrary.org/obo/MP_0006089 abnormal vestibular saccule morphology enlarged size of the cavity between the semicircular canals and the cochlea of the inner ear http://purl.obolibrary.org/obo/MP_0004317 small vestibular saccule http://purl.obolibrary.org/obo/MP_0006089 abnormal vestibular saccule morphology reduced size of the cavity between the semicircular canals and the cochlea of the inner ear http://purl.obolibrary.org/obo/MP_0004318 absent incus http://purl.obolibrary.org/obo/MP_0005106 abnormal incus morphology absence of the middle of the three auditory ossicles http://purl.obolibrary.org/obo/MP_0004319 absent malleus http://purl.obolibrary.org/obo/MP_0000029 abnormal malleus morphology absence of the largest of the three auditory ossicles, which resembles a club or hammer http://purl.obolibrary.org/obo/MP_0004320 split sternum http://purl.obolibrary.org/obo/MP_0000157 abnormal sternum morphology the appearance of an abnormal division in the long flat bone of the chest which articulates with clavicle and first seven rib pairs http://purl.obolibrary.org/obo/MP_0004321 short sternum http://purl.obolibrary.org/obo/MP_0000157 abnormal sternum morphology reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs http://purl.obolibrary.org/obo/MP_0004322 abnormal sternebra morphology http://purl.obolibrary.org/obo/MP_0000157 abnormal sternum morphology any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum http://purl.obolibrary.org/obo/MP_0004323 sternum hypoplasia http://purl.obolibrary.org/obo/MP_0000157 abnormal sternum morphology underdevelopment or reduced size, usually due to a reduced number of cells, in the sternum http://purl.obolibrary.org/obo/MP_0004324 vestibular hair cell degeneration http://purl.obolibrary.org/obo/MP_0003224 neuron degeneration degeneration or loss of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve http://purl.obolibrary.org/obo/MP_0004325 absent vestibular hair cells http://purl.obolibrary.org/obo/MP_0004328 decreased vestibular hair cell number absence of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve http://purl.obolibrary.org/obo/MP_0004326 abnormal vestibular hair cell number http://purl.obolibrary.org/obo/MP_0002623 abnormal vestibular hair cell morphology abnormal number of cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the internal ear http://purl.obolibrary.org/obo/MP_0004327 increased vestibular hair cell number http://purl.obolibrary.org/obo/MP_0006006 increased sensory neuron number increased number of cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the internal ear which are normally in synaptic contact with the vestibular nerve http://purl.obolibrary.org/obo/MP_0004328 decreased vestibular hair cell number http://purl.obolibrary.org/obo/MP_0004326 abnormal vestibular hair cell number decreased number of cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the internal ear which are normally in synaptic contact with the vestibular nerve http://purl.obolibrary.org/obo/MP_0004329 vestibular saccular degeneration http://purl.obolibrary.org/obo/MP_0006089 abnormal vestibular saccule morphology degeneration or loss of the smaller of the two sacs in the vestibule http://purl.obolibrary.org/obo/MP_0004330 abnormal vestibular saccular macula morphology http://purl.obolibrary.org/obo/MP_0006089 abnormal vestibular saccule morphology any structural anomaly of the oval neuroepithelial sensory receptor in the anterior wall of the saccule; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies http://purl.obolibrary.org/obo/MP_0004331 vestibular saccular macula degeneration http://purl.obolibrary.org/obo/MP_0004330 abnormal vestibular saccular macula morphology degeneration or loss of the oval neuroepithelial sensory receptor in the anterior wall of the saccule http://purl.obolibrary.org/obo/MP_0004332 utricular degeneration http://purl.obolibrary.org/obo/MP_0006090 abnormal utricle morphology degeneration or loss of the larger of the two sacs in the vestibule http://purl.obolibrary.org/obo/MP_0004333 abnormal utricular macula morphology http://purl.obolibrary.org/obo/MP_0006090 abnormal utricle morphology any structural anomaly of the neuroepithelial sensory receptor in the inferolateral wall of the utricle; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies; normally sensitive to linear acceleration in the longitudinal axis of the body and to gravitational influences http://purl.obolibrary.org/obo/MP_0004334 utricular macular degeneration http://purl.obolibrary.org/obo/MP_0004333 abnormal utricular macula morphology degeneration or loss of the neuroepithelial sensory receptor in the inferolateral wall of the utricle http://purl.obolibrary.org/obo/MP_0004335 enlarged utricle http://purl.obolibrary.org/obo/MP_0006090 abnormal utricle morphology increased size of the larger of the two sacs in the vestibule http://purl.obolibrary.org/obo/MP_0004336 small utricle http://purl.obolibrary.org/obo/MP_0006090 abnormal utricle morphology reduced size of the larger of the two sacs in the vestibule http://purl.obolibrary.org/obo/MP_0004337 clavicle hypoplasia http://purl.obolibrary.org/obo/MP_0004338 small clavicle underdevelopment or reduced size, usually due to a reduced number of cells, of one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula http://purl.obolibrary.org/obo/MP_0004338 small clavicle http://purl.obolibrary.org/obo/MP_0005298 abnormal clavicle morphology reduced size of one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula http://purl.obolibrary.org/obo/MP_0004339 absent clavicle http://purl.obolibrary.org/obo/MP_0005298 abnormal clavicle morphology missing one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula http://purl.obolibrary.org/obo/MP_0004340 short scapula http://purl.obolibrary.org/obo/MP_0004343 small scapula reduced length of either or both of the large, flat bones of the back part of the shoulder http://purl.obolibrary.org/obo/MP_0004341 absent scapula http://purl.obolibrary.org/obo/MP_0000149 abnormal scapula morphology missing either or both of the large, flat bones of the back part of the shoulder http://purl.obolibrary.org/obo/MP_0004342 scapular bone foramen http://purl.obolibrary.org/obo/MP_0000149 abnormal scapula morphology presence of a hole in either or both of the large, flat bones of the back part of the shoulder http://purl.obolibrary.org/obo/MP_0004343 small scapula http://purl.obolibrary.org/obo/MP_0000149 abnormal scapula morphology reduced size of either or both of the large, flat bones of the back part of the shoulder http://purl.obolibrary.org/obo/MP_0004344 scapular bone hypoplasia http://purl.obolibrary.org/obo/MP_0004343 small scapula underdevelopment or reduced size, usually due to a reduced number of cells, in either or both of the large, flat bones of the back part of the shoulder http://purl.obolibrary.org/obo/MP_0004345 abnormal acromion morphology http://purl.obolibrary.org/obo/MP_0000149 abnormal scapula morphology any structural anomaly of the lateral end of the spine of the scapula which projects as a broad flattened process and articulates with the clavicle, and forms the point of the shoulder http://purl.obolibrary.org/obo/MP_0004346 absent acromion http://purl.obolibrary.org/obo/MP_0004345 abnormal acromion morphology lack of the lateral end of the spine of the scapula which projects as a broad flattened process and articulates with the clavicle, and forms the point of the shoulder http://purl.obolibrary.org/obo/MP_0004391 abnormal respiratory conducting tube morphology http://purl.obolibrary.org/obo/MP_0001175 abnormal lung morphology any structural anomaly of the tubes of the respiratory system that allow passage of air from the trachea to the terminal bronchioles http://purl.obolibrary.org/obo/MP_0004426 abnormal cochlear labyrinth morphology http://purl.obolibrary.org/obo/MP_0000035 abnormal membranous labyrinth morphology any structural anomaly in the portion of the membranous labyrinth concerned with the sense of hearing (vs. the vestibular labyrinth, which is concerned with the sense of equilibration) and innervated by the cochlear nerve; it is located within the cochlea of the bony labyrinth, and consists of the cochlear duct, which contains the spiral organ http://purl.obolibrary.org/obo/MP_0004427 abnormal vestibular labyrinth morphology http://purl.obolibrary.org/obo/MP_0000035 abnormal membranous labyrinth morphology any structural anomaly in the portion of the membranous labyrinth concerned with the sense of equilibration (vs. the cochlear labyrinth, which is concerned with the sense of hearing) and innervated by the vestibular nerve; it is located within the semicircular canals and vestibule of the bony labyrinth, and consists of the utricle, saccule, and the semicircular, utriculosaccular, and endolymphatic ducts http://purl.obolibrary.org/obo/MP_0004468 small zygomatic bone http://purl.obolibrary.org/obo/MP_0005270 abnormal zygomatic bone morphology reduced size of the quadrilateral bone that forms the prominence of the cheek http://purl.obolibrary.org/obo/MP_0004470 small nasal bone http://purl.obolibrary.org/obo/MP_0000102 abnormal nasal bone morphology reduced size of either of two rectangular bone plates forming the bridge of the nose http://purl.obolibrary.org/obo/MP_0004474 enlarged nasal bone http://purl.obolibrary.org/obo/MP_0000102 abnormal nasal bone morphology increased size of either of two rectangular bone plates forming the bridge of the nose http://purl.obolibrary.org/obo/MP_0004497 decreased organ of Corti supporting cell number http://purl.obolibrary.org/obo/MP_0004496 abnormal organ of Corti supporting cell number decreased number of the highly differentiated epithelial cells with distinctive morphological features which surround the hair cells in the organ of Corti http://purl.obolibrary.org/obo/MP_0004508 abnormal pectoral girdle bone morphology http://purl.obolibrary.org/obo/MP_0009250 abnormal appendicular skeleton morphology any structural anomaly of the bones of the shoulder by which the limbs attach to the axial skeleton http://purl.obolibrary.org/obo/MP_0004537 abnormal palatine bone horizontal plate morphology http://purl.obolibrary.org/obo/MP_0009891 abnormal palate bone morphology any structural anomaly of the bony plate of the palatine bone that normally fuses with maxillary shelf to form secondary (hard) palate http://purl.obolibrary.org/obo/MP_0004538 abnormal maxillary shelf morphology http://purl.obolibrary.org/obo/MP_0009891 abnormal palate bone morphology any structural anomaly of the bony projection of the maxilla that normally fuses with palatine shelf to form secondary (hard) palate http://purl.obolibrary.org/obo/MP_0004540 small maxilla http://purl.obolibrary.org/obo/MP_0000455 abnormal maxilla morphology reduced size of the upper bony framework of the mouth where the superior teeth are held http://purl.obolibrary.org/obo/MP_0004543 abnormal sperm physiology http://purl.obolibrary.org/obo/MP_0003698 abnormal male reproductive system physiology anomaly in the normal function of spermatozoa http://purl.obolibrary.org/obo/MP_0004592 small mandible http://purl.obolibrary.org/obo/MP_0000458 abnormal mandible morphology reduced size of the lower bony framework of the mouth where the inferior teeth are held http://purl.obolibrary.org/obo/MP_0004600 abnormal vertebral transverse process morphology http://purl.obolibrary.org/obo/MP_0004599 abnormal vertebral arch morphology any structural anomaly of the bony protrusions on either side of the arch of a vertebrae at the point where the lamina joins the pedicle, between the superior and inferior articular processes; muscles and ligaments attach to these processes http://purl.obolibrary.org/obo/MP_0004604 abnormal vertebral pedicle morphology http://purl.obolibrary.org/obo/MP_0004599 abnormal vertebral arch morphology any structural anomaly of the two short, thick processes, which project backward, one on either side, from the upper part of the body to the laminae http://purl.obolibrary.org/obo/MP_0004624 abnormal thoracic cage morphology http://purl.obolibrary.org/obo/MP_0002114 abnormal axial skeleton morphology any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum http://purl.obolibrary.org/obo/MP_0004625 abnormal rib attachment http://purl.obolibrary.org/obo/MP_0004624 abnormal thoracic cage morphology any anomaly in the in the normal joining of the ribs to the vertebral column or to the sternum http://purl.obolibrary.org/obo/MP_0004631 abnormal auditory cortex morphology http://purl.obolibrary.org/obo/MP_0000801 abnormal temporal lobe morphology any structural anomaly in the region of the cerebral cortex that receives the auditory radiation from the medial geniculate body, a thalamic cell group receiving auditory input from the cochlear nuclei in the rhombencephalon and is responsible for processing of auditory (sound) information http://purl.obolibrary.org/obo/MP_0004644 increased vertebrae number http://purl.obolibrary.org/obo/MP_0004643 abnormal vertebrae number an increase over the normal number of the bony segments of the spinal column http://purl.obolibrary.org/obo/MP_0004645 decreased vertebrae number http://purl.obolibrary.org/obo/MP_0004643 abnormal vertebrae number a reduction from the normal number of the bony segments of the spinal column http://purl.obolibrary.org/obo/MP_0004686 decreased length of long bones http://purl.obolibrary.org/obo/MP_0003723 abnormal long bone morphology reduced end-to-end length of the several elongated bones of the extremities http://purl.obolibrary.org/obo/MP_0004695 increased length of long bones http://purl.obolibrary.org/obo/MP_0003723 abnormal long bone morphology greater end-to-end length of the several elongated bones of the extremities http://purl.obolibrary.org/obo/MP_0004703 abnormal vertebral column morphology http://purl.obolibrary.org/obo/MP_0002114 abnormal axial skeleton morphology any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord http://purl.obolibrary.org/obo/MP_0004720 abnormal platelet morphology http://purl.obolibrary.org/obo/MP_0000228 abnormal thrombopoiesis any structural anomaly of blood plasma cells derived from megakaryocytes, which function to promote blood clotting http://purl.obolibrary.org/obo/MP_0004787 abnormal dorsal aorta morphology http://purl.obolibrary.org/obo/MP_0003410 abnormal artery development any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation http://purl.obolibrary.org/obo/MP_0004806 absent germ cells http://purl.obolibrary.org/obo/MP_0002209 decreased germ cell number absence of germ cells, that is, any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated http://purl.obolibrary.org/obo/MP_0004811 abnormal neuron physiology http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology any functional anomaly of the cells of the nervous system that receive, conduct, and transmit impulses http://purl.obolibrary.org/obo/MP_0004818 increased skeletal muscle mass http://purl.obolibrary.org/obo/MP_0004817 abnormal skeletal muscle mass increase in the physical bulk, or total amount of matter contained within skeletal muscle http://purl.obolibrary.org/obo/MP_0004832 enlarged ovary http://purl.obolibrary.org/obo/MP_0004853 abnormal ovary size increased size of the female reproductive gland containing the germ cells http://purl.obolibrary.org/obo/MP_0004847 abnormal liver weight http://purl.obolibrary.org/obo/MP_0004848 abnormal liver size anomaly in the average weight of the bile-secreting exocrine gland http://purl.obolibrary.org/obo/MP_0004848 abnormal liver size http://purl.obolibrary.org/obo/MP_0000598 abnormal liver morphology anomaly in the average size of the liver http://purl.obolibrary.org/obo/MP_0004849 abnormal testis size http://purl.obolibrary.org/obo/MP_0001146 abnormal testis morphology anomaly in the size of the male reproductive glands http://purl.obolibrary.org/obo/MP_0004853 abnormal ovary size http://purl.obolibrary.org/obo/MP_0001126 abnormal ovary morphology anomaly in the average size of the female reproductive gland containing the germ cells http://purl.obolibrary.org/obo/MP_0004857 abnormal heart weight http://purl.obolibrary.org/obo/MP_0005406 abnormal heart size anomaly in the average weight of the heart compared to controls http://purl.obolibrary.org/obo/MP_0004858 abnormal nervous system regeneration http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology changes in the ability or inability of healthy nervous system tissue to regenerate following injury or disease http://purl.obolibrary.org/obo/MP_0004859 abnormal synaptic plasticity http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology anomaly in the ability of a synapse to change its strength as a result of successive activations http://purl.obolibrary.org/obo/MP_0004870 small premaxilla http://purl.obolibrary.org/obo/MP_0002820 abnormal premaxilla morphology reduced size of the anterior and interior portion of the maxilla http://purl.obolibrary.org/obo/MP_0004874 abnormal timing of postnatal eyelid opening http://purl.obolibrary.org/obo/MP_0001340 abnormal eyelid morphology anomaly in the average time for the first postnatal eye opening, or failure of eyes to ever open http://purl.obolibrary.org/obo/MP_0004881 abnormal lung size http://purl.obolibrary.org/obo/MP_0001175 abnormal lung morphology anomaly in the size of the lung compared to controls http://purl.obolibrary.org/obo/MP_0004882 enlarged lung http://purl.obolibrary.org/obo/MP_0004881 abnormal lung size increased size of the lung compared to controls http://purl.obolibrary.org/obo/MP_0004884 abnormal testis physiology http://purl.obolibrary.org/obo/MP_0013327 abnormal male reproductive gland physiology any functional anomaly of the male reproductive glands http://purl.obolibrary.org/obo/MP_0004901 decreased male germ cell number http://purl.obolibrary.org/obo/MP_0006362 abnormal male germ cell morphology reduced numbers of male germ cells whether they are undifferentiated or fully differentiated http://purl.obolibrary.org/obo/MP_0004902 abnormal uterus size http://purl.obolibrary.org/obo/MP_0001120 abnormal uterus morphology anomaly in the size of the female organ of gestation http://purl.obolibrary.org/obo/MP_0004906 enlarged uterus http://purl.obolibrary.org/obo/MP_0004902 abnormal uterus size increased size of the female muscular organ of gestation http://purl.obolibrary.org/obo/MP_0004907 abnormal seminal vesicle size http://purl.obolibrary.org/obo/MP_0002059 abnormal seminal vesicle morphology anomaly in the size of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens http://purl.obolibrary.org/obo/MP_0004924 abnormal behavior http://purl.obolibrary.org/obo/MP_0005386 behavior/neurological phenotype any anomaly in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls http://purl.obolibrary.org/obo/MP_0004937 dilated heart http://purl.obolibrary.org/obo/MP_0000266 abnormal heart morphology stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid http://purl.obolibrary.org/obo/MP_0004939 abnormal B cell morphology http://purl.obolibrary.org/obo/MP_0002619 abnormal lymphocyte morphology any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens http://purl.obolibrary.org/obo/MP_0004945 abnormal bone resorption http://purl.obolibrary.org/obo/MP_0002998 abnormal bone remodeling anomaly in the process of degrading the organic and inorganic phases of bone by absorption, usually by the abnormal function or by absence of osteoclasts http://purl.obolibrary.org/obo/MP_0004947 skin inflammation http://purl.obolibrary.org/obo/MP_0005501 abnormal skin physiology local accumulation of fluid, plasma proteins, and leukocytes in the skin http://purl.obolibrary.org/obo/MP_0004957 abnormal blastocyst morphology http://purl.obolibrary.org/obo/MP_0009781 abnormal preimplantation embryo development any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo http://purl.obolibrary.org/obo/MP_0004958 enlarged prostate gland http://purl.obolibrary.org/obo/MP_0004959 abnormal prostate gland size increased size of the gland in males that secretes part of the seminiferous fluid http://purl.obolibrary.org/obo/MP_0004959 abnormal prostate gland size http://purl.obolibrary.org/obo/MP_0001158 abnormal prostate gland morphology anomaly in the average size of the gland in males that secretes part of the seminiferous fluid http://purl.obolibrary.org/obo/MP_0004963 abnormal blastocoele morphology http://purl.obolibrary.org/obo/MP_0004957 abnormal blastocyst morphology any structural anomaly the fluid-filled cavity of the blastocyst of the preimplantation embryo of mammals http://purl.obolibrary.org/obo/MP_0004996 abnormal CNS synapse formation http://purl.obolibrary.org/obo/MP_0003861 abnormal nervous system development any anomaly in the process of generating the initial connections between an axon and effector tissue or neuron http://purl.obolibrary.org/obo/MP_0005005 abnormal self tolerance http://purl.obolibrary.org/obo/MP_0005000 abnormal immune tolerance a defect in the normal lack of response to autologous (self) antigens http://purl.obolibrary.org/obo/MP_0005010 abnormal CD8-positive, alpha beta T cell morphology http://purl.obolibrary.org/obo/MP_0002435 abnormal effector T cell morphology any structural anomaly of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions http://purl.obolibrary.org/obo/MP_0005014 increased B cell number http://purl.obolibrary.org/obo/MP_0005013 increased lymphocyte cell number greater than normal number of cells that are formed in the bone marrow, migrate to the peripheral lymphatic system, and mature into plasma cells or memory cells; these cells are involved in humoral immunity http://purl.obolibrary.org/obo/MP_0005015 increased T cell number http://purl.obolibrary.org/obo/MP_0005013 increased lymphocyte cell number greater than normal T cell numbers http://purl.obolibrary.org/obo/MP_0005016 decreased lymphocyte cell number http://purl.obolibrary.org/obo/MP_0000717 abnormal lymphocyte cell number fewer than normal number of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells http://purl.obolibrary.org/obo/MP_0005018 decreased T cell number http://purl.obolibrary.org/obo/MP_0006387 abnormal T cell number fewer than normal T cell numbers http://purl.obolibrary.org/obo/MP_0005019 abnormal early pro-B cell http://purl.obolibrary.org/obo/MP_0005432 abnormal pro-B cell morphology any structural anomaly of cells in the B lymphocyte lineage that undergo D-J rearrangement of the immunoglobulin heavy chain http://purl.obolibrary.org/obo/MP_0005020 abnormal late pro-B cell http://purl.obolibrary.org/obo/MP_0005432 abnormal pro-B cell morphology any structural anomaly of the cells in the B lymphocyte lineage that undergo V-DJ rearrangement of the immunoglobulin heavy chain http://purl.obolibrary.org/obo/MP_0005023 abnormal wound healing http://purl.obolibrary.org/obo/MP_0005164 abnormal response to injury aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means http://purl.obolibrary.org/obo/MP_0005025 abnormal response to infection http://purl.obolibrary.org/obo/MP_0001790 abnormal immune system physiology any anomaly in the body's reaction to invasion and multiplication of microorganisms in its tissues, or the body's reaction to components of or toxins produced by pathogenic microorganisms http://purl.obolibrary.org/obo/MP_0005029 abnormal amnion morphology http://purl.obolibrary.org/obo/MP_0002086 abnormal extraembryonic tissue morphology any structural anomaly of the thin innermost layer of the extraembryonic membranes that contains the amniotic fluid; the membrane forms a closed sac in which the embryo and later, the fetus, is suspended and protected http://purl.obolibrary.org/obo/MP_0005031 abnormal trophoblast layer morphology http://purl.obolibrary.org/obo/MP_0001711 abnormal placenta morphology any structural anomaly of the mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta http://purl.obolibrary.org/obo/MP_0005032 abnormal ectoplacental cone morphology http://purl.obolibrary.org/obo/MP_0012056 abnormal polar trophectoderm morphology any structural anomaly of the thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta http://purl.obolibrary.org/obo/MP_0005033 abnormal trophoblast giant cells http://purl.obolibrary.org/obo/MP_0012057 abnormal mural trophectoderm morphology anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta http://purl.obolibrary.org/obo/MP_0005034 abnormal anus morphology http://purl.obolibrary.org/obo/MP_0009053 abnormal anal canal morphology any structural anomaly of the lower opening of the digestive tract http://purl.obolibrary.org/obo/MP_0005036 diarrhea http://purl.obolibrary.org/obo/MP_0003866 abnormal defecation abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel http://purl.obolibrary.org/obo/MP_0005048 thrombosis http://purl.obolibrary.org/obo/MP_0002551 abnormal blood coagulation formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements http://purl.obolibrary.org/obo/MP_0005061 abnormal eosinophil morphology http://purl.obolibrary.org/obo/MP_0002441 abnormal granulocyte morphology any structural anomaly of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin and is involved in clearance of parasitic infections and in allergic reactions http://purl.obolibrary.org/obo/MP_0005065 abnormal neutrophil morphology http://purl.obolibrary.org/obo/MP_0008251 abnormal phagocyte morphology any structural anomaly of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes http://purl.obolibrary.org/obo/MP_0005072 abnormal hair follicle melanin granule morphology http://purl.obolibrary.org/obo/MP_0005075 abnormal melanosome morphology any structural anomaly of the pigment particles in the hair follicles http://purl.obolibrary.org/obo/MP_0005076 abnormal cell differentiation http://purl.obolibrary.org/obo/MP_0005621 abnormal cell physiology anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history http://purl.obolibrary.org/obo/MP_0005083 abnormal biliary tract morphology http://purl.obolibrary.org/obo/MP_0002138 abnormal hepatobiliary system morphology any structural anomaly of the gall bladder or its bile ducts http://purl.obolibrary.org/obo/MP_0005084 abnormal gallbladder morphology http://purl.obolibrary.org/obo/MP_0005083 abnormal biliary tract morphology any structural anomaly of the organ which serves as a storage reservoir for bile http://purl.obolibrary.org/obo/MP_0005085 abnormal gallbladder physiology http://purl.obolibrary.org/obo/MP_0002139 abnormal hepatobiliary system physiology any functional anomaly of the organ that stores and concentrates bile http://purl.obolibrary.org/obo/MP_0005105 abnormal middle ear ossicle morphology http://purl.obolibrary.org/obo/MP_0002116 abnormal craniofacial bone morphology any structural anomaly of the three small bones of the middle ear http://purl.obolibrary.org/obo/MP_0005106 abnormal incus morphology http://purl.obolibrary.org/obo/MP_0005105 abnormal middle ear ossicle morphology any structural anomaly of the middle of the three auditory ossicles http://purl.obolibrary.org/obo/MP_0005107 abnormal stapes morphology http://purl.obolibrary.org/obo/MP_0005105 abnormal middle ear ossicle morphology any structural anomaly of the smallest and innermost of the three auditory ossicles http://purl.obolibrary.org/obo/MP_0005117 increased circulating pituitary hormone level http://purl.obolibrary.org/obo/MP_0005116 abnormal circulating pituitary hormone level greater than expected concentration of any of the pituitary hormones in the blood http://purl.obolibrary.org/obo/MP_0005118 decreased circulating pituitary hormone level http://purl.obolibrary.org/obo/MP_0005116 abnormal circulating pituitary hormone level less than expected concentration of any of the pituitary hormones found in the blood http://purl.obolibrary.org/obo/MP_0005128 decreased adrenocorticotropin level http://purl.obolibrary.org/obo/MP_0003972 decreased pituitary hormone level decreased concentration of adrenocorticotropic hormone http://purl.obolibrary.org/obo/MP_0005129 increased adrenocorticotropin level http://purl.obolibrary.org/obo/MP_0003973 increased pituitary hormone level increased concentration of adrenocorticotropic hormone http://purl.obolibrary.org/obo/MP_0005130 decreased follicle stimulating hormone level http://purl.obolibrary.org/obo/MP_0003972 decreased pituitary hormone level less than expected concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis http://purl.obolibrary.org/obo/MP_0005131 increased follicle stimulating hormone level http://purl.obolibrary.org/obo/MP_0003973 increased pituitary hormone level greater than expected concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis http://purl.obolibrary.org/obo/MP_0005132 decreased luteinizing hormone level http://purl.obolibrary.org/obo/MP_0003972 decreased pituitary hormone level lower than normal concentration of LH http://purl.obolibrary.org/obo/MP_0005133 increased luteinizing hormone level http://purl.obolibrary.org/obo/MP_0003973 increased pituitary hormone level higher than normal levels of LH http://purl.obolibrary.org/obo/MP_0005147 prostate gland hypoplasia http://purl.obolibrary.org/obo/MP_0002774 small prostate gland underdevelopment or reduced size of the prostate, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0005164 abnormal response to injury http://purl.obolibrary.org/obo/MP_0005376 homeostasis/metabolism phenotype anomaly in the body's reaction to trauma, especially that by physical means http://purl.obolibrary.org/obo/MP_0005165 increased susceptibility to injury http://purl.obolibrary.org/obo/MP_0005164 abnormal response to injury greater than the normal reaction to trauma, especially that by physical means http://purl.obolibrary.org/obo/MP_0005166 decreased susceptibility to injury http://purl.obolibrary.org/obo/MP_0005164 abnormal response to injury less than the normal reaction to trauma, especially that by physical means http://purl.obolibrary.org/obo/MP_0005178 increased circulating cholesterol level http://purl.obolibrary.org/obo/MP_0003982 increased cholesterol level greater than the normal amount in the blood of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues http://purl.obolibrary.org/obo/MP_0005179 decreased circulating cholesterol level http://purl.obolibrary.org/obo/MP_0003983 decreased cholesterol level less than the normal amount in the blood of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues http://purl.obolibrary.org/obo/MP_0005180 abnormal circulating testosterone level http://purl.obolibrary.org/obo/MP_0011385 abnormal testosterone level anomaly in the blood concentration of a potent androgen that promotes development of male secondary sex characteristics and the development of spermatozoa and may regulate sexual desire and help maintain bone and muscle health in both males and females http://purl.obolibrary.org/obo/MP_0005187 abnormal penis morphology http://purl.obolibrary.org/obo/MP_0009199 abnormal external male genitalia morphology any structural anomaly of the organ of copulation and urination in the male http://purl.obolibrary.org/obo/MP_0005189 abnormal anogenital distance http://purl.obolibrary.org/obo/MP_0003315 abnormal perineum morphology in comparison to the norm, aberration in the measure of the length of space from the genitals to the anus http://purl.obolibrary.org/obo/MP_0005193 abnormal anterior eye segment morphology http://purl.obolibrary.org/obo/MP_0002092 abnormal eye morphology any structural anomaly of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) http://purl.obolibrary.org/obo/MP_0005194 abnormal anterior uvea morphology http://purl.obolibrary.org/obo/MP_0005197 abnormal uvea morphology any structural anomaly of any of the parts of the front, or ventral, portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris http://purl.obolibrary.org/obo/MP_0005195 abnormal posterior eye segment morphology http://purl.obolibrary.org/obo/MP_0002092 abnormal eye morphology any structural anomaly of any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive) http://purl.obolibrary.org/obo/MP_0005198 abnormal aqueous drainage system morphology http://purl.obolibrary.org/obo/MP_0005194 abnormal anterior uvea morphology any structural anomaly of the structures associated with drainage of the aqueous humor from the eye, that include the trabecular meshwork, Schlemm's canal, the uveoscleral network, and the aqueous veins http://purl.obolibrary.org/obo/MP_0005203 abnormal trabecular meshwork morphology http://purl.obolibrary.org/obo/MP_0004221 abnormal iridocorneal angle any structural anomaly in the pore-like structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates http://purl.obolibrary.org/obo/MP_0005204 abnormal canal of Schlemm morphology http://purl.obolibrary.org/obo/MP_0004221 abnormal iridocorneal angle any structural anomaly in the vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation http://purl.obolibrary.org/obo/MP_0005217 abnormal pancreatic beta cell morphology http://purl.obolibrary.org/obo/MP_0005215 abnormal pancreatic islet morphology any structural anomaly of a cell that secretes insulin and is located towards the center of the islets of Langerhans in the pancreas http://purl.obolibrary.org/obo/MP_0005220 abnormal exocrine pancreas morphology http://purl.obolibrary.org/obo/MP_0001944 abnormal pancreas morphology any structural anomaly of the acinar gland portion of the pancreas that secretes digestive enzymes http://purl.obolibrary.org/obo/MP_0005221 abnormal rostral-caudal axis patterning http://purl.obolibrary.org/obo/MP_0002084 abnormal developmental patterning anomaly in the development or formation of the axis that runs from the head to the tail of the body http://purl.obolibrary.org/obo/MP_0005238 increased brain size http://purl.obolibrary.org/obo/MP_0000771 abnormal brain size larger than the normal physical proportions of the brain http://purl.obolibrary.org/obo/MP_0005248 abnormal Harderian gland morphology http://purl.obolibrary.org/obo/MP_0002163 abnormal gland morphology any structural anomaly of the retroocular sebaceous gland found within the orbit of mammals that possess a nictitating membrane (third eyelid); the chief products of the gland vary between different groups of vertebrates, and epithelial cells possess granules or vacuoles whose contents may be mucous, serous or lipid; in rodents, the Harderian gland is especially large and secretes lipids (by a merocrine mechanism), melatonin and porphyrins; ascribed functions include a role in lubrication and protection for the eyeball and nictitating membrane (by lipids), photoprotection (by porphyrin), photoreception (by regulation of the incidence of light on the retina), and thermoregulation (in some rodents)of the sebaceous gland located behind the eyeball that excretes fluid that facilitates movement of the nictitating membrane http://purl.obolibrary.org/obo/MP_0005252 abnormal Meibomian gland morphology http://purl.obolibrary.org/obo/MP_0009535 abnormal skin sebaceous gland morphology any structural anomaly of the sebaceous glands embedded in the tarsal plate of each eyelid http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology http://purl.obolibrary.org/obo/MP_0005391 vision/eye phenotype any functional anomaly and/or activity of the spheroid organ and optic nerve that serves to detect light http://purl.obolibrary.org/obo/MP_0005266 abnormal metabolism http://purl.obolibrary.org/obo/MP_0005376 homeostasis/metabolism phenotype any anomaly in the processes that cause many of the chemical changes in living organisms, including anabolism and catabolism; metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation http://purl.obolibrary.org/obo/MP_0005269 abnormal occipital bone morphology http://purl.obolibrary.org/obo/MP_0000074 abnormal neurocranium morphology any structural anomaly of the bone at the lower, posterior part of the skull http://purl.obolibrary.org/obo/MP_0005274 abnormal viscerocranium morphology http://purl.obolibrary.org/obo/MP_0000438 abnormal cranium morphology any structural anomaly of the part of the skull that comprises the facial bones http://purl.obolibrary.org/obo/MP_0005275 abnormal skin tensile strength http://purl.obolibrary.org/obo/MP_0005501 abnormal skin physiology change from the normal maximum tension the skin can withstand without tearing http://purl.obolibrary.org/obo/MP_0005277 abnormal brainstem morphology http://purl.obolibrary.org/obo/MP_0002152 abnormal brain morphology any structural anomaly of the stalk-like part of the brain that comprises the midbrain (aka mesencephalon), the pons (aka pons Varolii), and the medulla oblongata, and connects the cerebral hemispheres with the cervical spinal cord http://purl.obolibrary.org/obo/MP_0005278 abnormal cholesterol homeostasis http://purl.obolibrary.org/obo/MP_0002118 abnormal lipid homeostasis anomaly in the processes involved in the maintenance of an internal equilibrium of cholesterol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues http://purl.obolibrary.org/obo/MP_0005281 increased fatty acid level http://purl.obolibrary.org/obo/MP_0005280 abnormal fatty acid level elevated concentration of aliphatic monocarboxylic acids derived from or contained in esterified form in an animal or vegetable fat, oil or wax; natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated http://purl.obolibrary.org/obo/MP_0005282 decreased fatty acid level http://purl.obolibrary.org/obo/MP_0005280 abnormal fatty acid level reduction in the concentration of aliphatic monocarboxylic acids derived from or contained in esterified form in an animal or vegetable fat, oil or wax; natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated http://purl.obolibrary.org/obo/MP_0005294 abnormal heart ventricle morphology http://purl.obolibrary.org/obo/MP_0000266 abnormal heart morphology any structural anomaly of one or both of the two lower chambers of the heart http://purl.obolibrary.org/obo/MP_0005298 abnormal clavicle morphology http://purl.obolibrary.org/obo/MP_0004508 abnormal pectoral girdle bone morphology any structural anomaly of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula http://purl.obolibrary.org/obo/MP_0005300 abnormal corneal stroma morphology http://purl.obolibrary.org/obo/MP_0001312 abnormal cornea morphology any structural anomaly of the lamellated connective tissue of the cornea between the Bowman and Descemet membranes http://purl.obolibrary.org/obo/MP_0005301 abnormal corneal endothelium morphology http://purl.obolibrary.org/obo/MP_0001312 abnormal cornea morphology any structural anomaly of the single layer of large flattened cells that cover the surface of the cornea http://purl.obolibrary.org/obo/MP_0005306 abnormal phalanx morphology http://purl.obolibrary.org/obo/MP_0011504 abnormal limb long bone morphology any structural anomaly of any of the long bones of the digits http://purl.obolibrary.org/obo/MP_0005310 abnormal salivary gland physiology http://purl.obolibrary.org/obo/MP_0002164 abnormal gland physiology any functional anomaly of any of the glands in the mouth that secrete saliva http://purl.obolibrary.org/obo/MP_0005311 abnormal circulating amino acid level http://purl.obolibrary.org/obo/MP_0005332 abnormal amino acid level any anomaly in the amount in the blood of a carboxylic acid containing one or more amino groups (-NH2) and a carboxyl (-COOH) group http://purl.obolibrary.org/obo/MP_0005316 abnormal response to tactile stimuli http://purl.obolibrary.org/obo/MP_0012079 abnormal spinal reflex anomaly in the reflex action normally induced by touch or pain http://purl.obolibrary.org/obo/MP_0005317 increased triglyceride level http://purl.obolibrary.org/obo/MP_0000187 abnormal triglyceride level greater concentration of naturally occurring esters of three fatty acids and glycerol; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver http://purl.obolibrary.org/obo/MP_0005318 decreased triglyceride level http://purl.obolibrary.org/obo/MP_0000187 abnormal triglyceride level reduced concentration of naturally occurring esters of three fatty acids and glycerol; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver http://purl.obolibrary.org/obo/MP_0005319 abnormal enzyme/ coenzyme level http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis altered level of any enzyme or their cofactors, that act as catalysts to induce chemical changes in other substances http://purl.obolibrary.org/obo/MP_0005325 abnormal renal glomerulus morphology http://purl.obolibrary.org/obo/MP_0002827 abnormal renal corpuscle morphology any structural anomaly of the tuft formed of capillary loops and mesangium at the beginning of each nephretic tubule in the kidney that normally function as a filtration unit http://purl.obolibrary.org/obo/MP_0005329 abnormal myocardium layer morphology http://purl.obolibrary.org/obo/MP_0010545 abnormal heart layer morphology any structural anomaly of the middle layer of the heart, comprised mainly of striated cardiac muscle fibers http://purl.obolibrary.org/obo/MP_0005330 cardiomyopathy http://purl.obolibrary.org/obo/MP_0002106 abnormal muscle physiology diseases of the heart (myocardium); may result from many causes http://purl.obolibrary.org/obo/MP_0005334 abnormal fat pad morphology http://purl.obolibrary.org/obo/MP_0000003 abnormal adipose tissue morphology any structural anomaly of the encapsulated adipose tissue http://purl.obolibrary.org/obo/MP_0005342 abnormal intestinal lipid absorption http://purl.obolibrary.org/obo/MP_0002118 abnormal lipid homeostasis any anomaly in the ability of the body to take up lipids into the blood by absorption from the small intestine http://purl.obolibrary.org/obo/MP_0005345 abnormal circulating corticosterone level http://purl.obolibrary.org/obo/MP_0003963 abnormal corticosterone level anomaly in the amount of the adrenocortical steroid in the blood that induces glycogen deposition and regulates sodium conservation and potassium secretion http://purl.obolibrary.org/obo/MP_0005346 abnormal circulating aldosterone level http://purl.obolibrary.org/obo/MP_0011415 abnormal aldosterone level anomaly in the blood concentration of the hormone that is secreted by the adrenal cortex and regulates sodium conservation and potassium secretion in the distal renal tubule http://purl.obolibrary.org/obo/MP_0005350 increased susceptibility to autoimmune disorder http://purl.obolibrary.org/obo/MP_0002425 altered susceptibility to autoimmune disorder greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides http://purl.obolibrary.org/obo/MP_0005351 decreased susceptibility to autoimmune disorder http://purl.obolibrary.org/obo/MP_0002425 altered susceptibility to autoimmune disorder reduced likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides http://purl.obolibrary.org/obo/MP_0005355 enlarged thyroid gland http://purl.obolibrary.org/obo/MP_0000681 abnormal thyroid gland morphology increased size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin http://purl.obolibrary.org/obo/MP_0005358 abnormal incisor morphology http://purl.obolibrary.org/obo/MP_0002100 abnormal tooth morphology any structural anomaly of the teeth, normally consisting of two pairs, top and bottom, of the long teeth that are the most anterior and prominent in the jaw http://purl.obolibrary.org/obo/MP_0005360 urolithiasis http://purl.obolibrary.org/obo/MP_0000516 abnormal renal/urinary system morphology presence of calculi in any part of the urinary system http://purl.obolibrary.org/obo/MP_0005361 small pituitary gland http://purl.obolibrary.org/obo/MP_0008936 abnormal pituitary gland size reduced size of the pituitary gland, the compound gland suspended from the base of the hypothalamus http://purl.obolibrary.org/obo/MP_0005362 abnormal Langerhans cell physiology http://purl.obolibrary.org/obo/MP_0002376 abnormal dendritic cell physiology atypical or failure of normal function of the stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus http://purl.obolibrary.org/obo/MP_0005366 variegated coat color http://purl.obolibrary.org/obo/MP_0000372 irregular coat pigmentation an irregular and random patchwork of two or more colors in the coat http://purl.obolibrary.org/obo/MP_0005375 adipose tissue phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype the observable morphological and physiological characteristics of mammalian fat tissue that are manifested through development and lifespan http://purl.obolibrary.org/obo/MP_0005385 cardiovascular system phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype the observable morphological and physiological characteristics of the mammalian heart, blood vessels, or circulatory system that are manifested through development and lifespan http://purl.obolibrary.org/obo/MP_0005402 abnormal action potential http://purl.obolibrary.org/obo/MP_0002272 abnormal nervous system electrophysiology change in the electric response of a nerve or other excitable tissue to its stimulation http://purl.obolibrary.org/obo/MP_0005404 abnormal axon morphology http://purl.obolibrary.org/obo/MP_0008415 abnormal neurite morphology any structural anomaly of the single process of a nerve cell that normally conducts impulses away from the cell body http://purl.obolibrary.org/obo/MP_0005405 axon degeneration http://purl.obolibrary.org/obo/MP_0002229 neurodegeneration retrogressive pathologic change in the single process of a nerve cell http://purl.obolibrary.org/obo/MP_0005406 abnormal heart size http://purl.obolibrary.org/obo/MP_0000266 abnormal heart morphology change from normal in the physical magnitude of the cardiac muscle or any of its component structures http://purl.obolibrary.org/obo/MP_0005407 hyperalgesia http://purl.obolibrary.org/obo/MP_0001970 abnormal pain threshold increased sensitivity to painful stimuli; can be due to inflammatory response or due to damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area) http://purl.obolibrary.org/obo/MP_0005410 abnormal fertilization http://purl.obolibrary.org/obo/MP_0001919 abnormal reproductive system physiology anomaly in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronuclei http://purl.obolibrary.org/obo/MP_0005416 abnormal circulating protein level http://purl.obolibrary.org/obo/MP_0008469 abnormal protein level anomaly in the amount in the blood of any of the macromolecules consisting of long chains of amino acids in peptide linkage http://purl.obolibrary.org/obo/MP_0005418 abnormal circulating hormone level http://purl.obolibrary.org/obo/MP_0009642 abnormal blood homeostasis any anomaly in the blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects http://purl.obolibrary.org/obo/MP_0005438 abnormal glycogen homeostasis http://purl.obolibrary.org/obo/MP_0002078 abnormal glucose homeostasis anomaly in the processes involved in the maintenance of an internal equilibrium of glycogen, a readily converted carbohydrate reserve found in most tissues of the body, especially liver and muscle http://purl.obolibrary.org/obo/MP_0005445 abnormal neurotransmitter secretion http://purl.obolibrary.org/obo/MP_0002204 abnormal neurotransmitter level anomaly in the production or release of endogenous signaling molecules into a synaptic cleft; neurotransmitters are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell http://purl.obolibrary.org/obo/MP_0005449 abnormal food intake http://purl.obolibrary.org/obo/MP_0001431 abnormal eating behavior any anomaly in the total number of calories/food amount taken in over time when compared to the normal state http://purl.obolibrary.org/obo/MP_0005451 abnormal body composition http://purl.obolibrary.org/obo/MP_0005378 growth/size/body phenotype aberrant relative amount and distribution of bone, body fat, muscle or lean tissue mass http://purl.obolibrary.org/obo/MP_0005452 abnormal adipose tissue amount http://purl.obolibrary.org/obo/MP_0000003 abnormal adipose tissue morphology more or less than the normal total amount of connective tissue composed of fat cells http://purl.obolibrary.org/obo/MP_0005455 increased susceptibility to weight gain http://purl.obolibrary.org/obo/MP_0011117 abnormal susceptibility to weight gain greater increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake http://purl.obolibrary.org/obo/MP_0005460 abnormal leukopoiesis http://purl.obolibrary.org/obo/MP_0002123 abnormal hematopoiesis any anomaly in the process of generating white blood cells (leukocytes) from the pluripotent hematopoietic stem cells of the bone marrow; two significant pathways generate various types of leukocytes: myelopoiesis, in which leukocytes in the blood are derived from myeloid stem cells, and lymphopoiesis, in which leukocytes of the lymphatic system (lymphocytes) are generated from lymphoid stem cells http://purl.obolibrary.org/obo/MP_0005461 abnormal dendritic cell morphology http://purl.obolibrary.org/obo/MP_0008246 abnormal leukocyte morphology any structural anomaly of a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation http://purl.obolibrary.org/obo/MP_0005468 abnormal thyroid hormone level http://purl.obolibrary.org/obo/MP_0003953 abnormal hormone level aberrant concentration of any of the hormones secreted by the thyroid gland http://purl.obolibrary.org/obo/MP_0005500 abnormal gustatory system morphology http://purl.obolibrary.org/obo/MP_0005394 taste/olfaction phenotype any structural anomaly of the organs involved in taste http://purl.obolibrary.org/obo/MP_0005501 abnormal skin physiology http://purl.obolibrary.org/obo/MP_0010771 integument phenotype any functional anomaly of the membranous protective covering of the body http://purl.obolibrary.org/obo/MP_0005502 abnormal renal/urinary system physiology http://purl.obolibrary.org/obo/MP_0005367 renal/urinary system phenotype any functional anomaly of any of the organs or tissues responsible for fluid volume regulation, regulating electrolytes, maintaining acid-base homeostasis, and elimination of water and water soluble waste products in an organism http://purl.obolibrary.org/obo/MP_0005503 abnormal tendon morphology http://purl.obolibrary.org/obo/MP_0005508 abnormal skeleton morphology any structural anomaly of the fibrous bands or cords of connective tissue at the ends of muscle fibers that attach muscles to bones and other structures http://purl.obolibrary.org/obo/MP_0005504 abnormal ligament morphology http://purl.obolibrary.org/obo/MP_0005508 abnormal skeleton morphology any structural anomaly of the flexible bands of fibrous tissue that connect the articular extremities of bones http://purl.obolibrary.org/obo/MP_0005508 abnormal skeleton morphology http://purl.obolibrary.org/obo/MP_0005390 skeleton phenotype any structural anomaly of the bony framework of the body in vertebrates http://purl.obolibrary.org/obo/MP_0005532 abnormal vascular resistance http://purl.obolibrary.org/obo/MP_0002128 abnormal blood circulation deviation from the normal force opposing the flow of blood through a vascular bed; it is equal to the difference in blood pressure across the vascular bed divided by the cardiac output http://purl.obolibrary.org/obo/MP_0005537 abnormal cerebral aqueduct morphology http://purl.obolibrary.org/obo/MP_0002200 abnormal brain ventricular system morphology any structural anomaly of the channel in the mesencephalon that connects the third and fourth ventricles http://purl.obolibrary.org/obo/MP_0005543 decreased cornea thickness http://purl.obolibrary.org/obo/MP_0011961 abnormal cornea thickness decreased thickness of the cornea, the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure http://purl.obolibrary.org/obo/MP_0005545 abnormal lens development http://purl.obolibrary.org/obo/MP_0001303 abnormal lens morphology aberrant formation of the transparent structure of the eye responsible for focusing light rays http://purl.obolibrary.org/obo/MP_0005546 choroidal neovascularization http://purl.obolibrary.org/obo/MP_0006237 abnormal choroid vasculature morphology new, abnormal, vessel development of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera http://purl.obolibrary.org/obo/MP_0005551 abnormal eye electrophysiology http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology any functional anomaly of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram) http://purl.obolibrary.org/obo/MP_0005559 increased circulating glucose level http://purl.obolibrary.org/obo/MP_0000188 abnormal circulating glucose level greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source http://purl.obolibrary.org/obo/MP_0005560 decreased circulating glucose level http://purl.obolibrary.org/obo/MP_0000188 abnormal circulating glucose level less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source http://purl.obolibrary.org/obo/MP_0005563 abnormal hemoglobin content http://purl.obolibrary.org/obo/MP_0001588 abnormal hemoglobin deviation from the normal total hemoglobin content in the circulating blood http://purl.obolibrary.org/obo/MP_0005575 increased pulmonary ventilation http://purl.obolibrary.org/obo/MP_0002338 abnormal pulmonary ventilation increase in the respiratory minute volume, or the total volume of gas per minute inspired or expired expressed in liters per minute; refers to the exchange of air between the total respiratory space and the environment http://purl.obolibrary.org/obo/MP_0005576 decreased pulmonary ventilation http://purl.obolibrary.org/obo/MP_0002338 abnormal pulmonary ventilation reduction in the respiratory minute volume, or the total volume of gas per minute inspired or expired expressed in liters per minute; refers to the exchange of air between the total respiratory space and the environment http://purl.obolibrary.org/obo/MP_0005579 absent outer ear http://purl.obolibrary.org/obo/MP_0002177 abnormal outer ear morphology absence of the auricles or external acoustic meatus http://purl.obolibrary.org/obo/MP_0005592 abnormal vascular smooth muscle morphology http://purl.obolibrary.org/obo/MP_0001614 abnormal blood vessel morphology any structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels http://purl.obolibrary.org/obo/MP_0005595 abnormal vascular smooth muscle physiology http://purl.obolibrary.org/obo/MP_0002106 abnormal muscle physiology any functional anomaly of the nonstriated, involuntary muscle tissue of the blood vessels http://purl.obolibrary.org/obo/MP_0005605 increased bone mass http://purl.obolibrary.org/obo/MP_0003795 abnormal bone structure an increase in the total amount of bone tissue contained in the skeleton http://purl.obolibrary.org/obo/MP_0005620 abnormal muscle contractility http://purl.obolibrary.org/obo/MP_0002106 abnormal muscle physiology aberrant ability of a muscle to shorten or to develop increased tension http://purl.obolibrary.org/obo/MP_0005621 abnormal cell physiology http://purl.obolibrary.org/obo/MP_0005384 cellular phenotype any functional anomaly of the vital processes of the cell http://purl.obolibrary.org/obo/MP_0005628 decreased circulating potassium level http://purl.obolibrary.org/obo/MP_0002668 abnormal circulating potassium level less than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle http://purl.obolibrary.org/obo/MP_0005636 abnormal mineral homeostasis http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis anomaly in the processes involved in the maintenance of an internal equilibrium of inorganic substances that have importance in body functions http://purl.obolibrary.org/obo/MP_0005637 abnormal iron homeostasis http://purl.obolibrary.org/obo/MP_0005636 abnormal mineral homeostasis anomaly in the processes involved in the maintenance of an internal equilibrium of iron that normally is a cofactor in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes http://purl.obolibrary.org/obo/MP_0005644 agonadal http://purl.obolibrary.org/obo/MP_0002211 abnormal primary sex determination denoting the absence of gonads http://purl.obolibrary.org/obo/MP_0005645 abnormal hypothalamus physiology http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology any functional anomaly of the ventral and medial region of the diencephalon forming the walls of the ventral half of the third ventricle, which is normally involved in the functions of the autonomic (visceral motor) nervous system and, through its vascular link with the anterior lobe of the pituitary gland, in endocrine mechanisms http://purl.obolibrary.org/obo/MP_0005646 abnormal pituitary gland physiology http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology any functional anomaly of this unpaired compound gland suspended from the base of the hypothalamus by a short extension of the infundibulum, the infundibular or pituitary stalk http://purl.obolibrary.org/obo/MP_0005647 abnormal sex gland physiology http://purl.obolibrary.org/obo/MP_0002164 abnormal gland physiology any functional anomaly of any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction http://purl.obolibrary.org/obo/MP_0005650 abnormal limb bud morphology http://purl.obolibrary.org/obo/MP_0006279 abnormal limb development any structural anomaly of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs http://purl.obolibrary.org/obo/MP_0005652 sex reversal http://purl.obolibrary.org/obo/MP_0002210 abnormal sex determination development of the reproductive system is inconsistent with the chromosomal sex http://purl.obolibrary.org/obo/MP_0005655 increased aggression http://purl.obolibrary.org/obo/MP_0002061 abnormal aggression-related behavior when compared to controls, subjects exhibit greater than the normal level of domineering, assault posture and/or hostile physical action http://purl.obolibrary.org/obo/MP_0005656 decreased aggression http://purl.obolibrary.org/obo/MP_0002061 abnormal aggression-related behavior when compared to controls, subjects exhibit less than the normal level of domineering, assault posture and/or hostile physical action http://purl.obolibrary.org/obo/MP_0005660 abnormal circulating adrenaline level http://purl.obolibrary.org/obo/MP_0005418 abnormal circulating hormone level aberrant concentration in the blood of a catecholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels http://purl.obolibrary.org/obo/MP_0005663 abnormal circulating noradrenaline level http://purl.obolibrary.org/obo/MP_0005418 abnormal circulating hormone level aberrant blood amount of the hormone secreted by the adrenal medulla and acts as a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS; noradrenaline is the demethylated biosynthetic precursor of epinephrine http://purl.obolibrary.org/obo/MP_0005666 abnormal adipose tissue physiology http://purl.obolibrary.org/obo/MP_0005375 adipose tissue phenotype any functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue http://purl.obolibrary.org/obo/MP_0006006 increased sensory neuron number http://purl.obolibrary.org/obo/MP_0008947 increased neuron number greater than normal numbers of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of sensory impulses http://purl.obolibrary.org/obo/MP_0006007 abnormal basal ganglion morphology http://purl.obolibrary.org/obo/MP_0000783 abnormal forebrain morphology any structural anomaly of any of a group of nuclei associated with the ability to carry out willed movements, including the caudate, putamen, nucleus accumbens, globus pallidus, substantia nigra, and subthalamic nucleus http://purl.obolibrary.org/obo/MP_0006011 abnormal endolymphatic duct morphology http://purl.obolibrary.org/obo/MP_0004427 abnormal vestibular labyrinth morphology any structural anomaly of the small membranous canal, connecting with both saccule and utricle of the membranous labyrinth, passing through the aqueduct of vestibule, and terminating in the endolymphatic sac http://purl.obolibrary.org/obo/MP_0006031 abnormal pharyngeal pouch morphology http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology any structural anomaly of the balloonlike diverticulae of the embryonic pharyngeal endoderm that line the inside of the branchial arches; these paired endodermal evaginations develop in a craniocaudal sequence between the branchial arches, e.g. pouch 1 lies between arches 1 and 2; in mammals, there are four well-developed pairs of pouches (the fifth and sixth pair is vestigial or absent); the pouch endoderm reaches the branchial groove ectoderm to form the double-layer branchial membranes that separate them http://purl.obolibrary.org/obo/MP_0006042 increased apoptosis http://purl.obolibrary.org/obo/MP_0012556 increased cell death greater than normal programmed cell death http://purl.obolibrary.org/obo/MP_0006043 decreased apoptosis http://purl.obolibrary.org/obo/MP_0012555 decreased cell death less than normal cell death http://purl.obolibrary.org/obo/MP_0006050 pulmonary fibrosis http://purl.obolibrary.org/obo/MP_0001175 abnormal lung morphology formation of fibrous tissue within the lung often resulting from inflammation or injury http://purl.obolibrary.org/obo/MP_0006055 abnormal vascular endothelial cell morphology http://purl.obolibrary.org/obo/MP_0009489 abnormal blood vessel endothelium morphology any structural anomaly of the cells that line the vasculature http://purl.obolibrary.org/obo/MP_0006065 abnormal heart position or orientation http://purl.obolibrary.org/obo/MP_0000266 abnormal heart morphology the heart is displaced from the normal left-sided position and/or orientation http://purl.obolibrary.org/obo/MP_0006069 abnormal retinal neuronal layer morphology http://purl.obolibrary.org/obo/MP_0003727 abnormal retinal layer morphology any structural anomaly of any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments http://purl.obolibrary.org/obo/MP_0006082 CNS inflammation http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord http://purl.obolibrary.org/obo/MP_0006084 abnormal circulating phospholipid level http://purl.obolibrary.org/obo/MP_0004777 abnormal phospholipid level any anomaly in the concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group http://purl.obolibrary.org/obo/MP_0006089 abnormal vestibular saccule morphology http://purl.obolibrary.org/obo/MP_0004425 abnormal otolith organ morphology any structural anomaly of the smaller of the two sacs in the vestibule http://purl.obolibrary.org/obo/MP_0006090 abnormal utricle morphology http://purl.obolibrary.org/obo/MP_0004425 abnormal otolith organ morphology any structural anomaly of the larger of the two sacs in the vestibule http://purl.obolibrary.org/obo/MP_0006092 abnormal olfactory sensory neuron morphology http://purl.obolibrary.org/obo/MP_0008789 abnormal olfactory epithelium morphology any structural anomaly of the neurons in the olfactory epithelium that are activated by specific odorants http://purl.obolibrary.org/obo/MP_0006104 abnormal tectum morphology http://purl.obolibrary.org/obo/MP_0006103 abnormal midbrain roof plate morphology any structural anomaly of the rostral part of the midbrain roof http://purl.obolibrary.org/obo/MP_0006107 abnormal fetal atrioventricular canal morphology http://purl.obolibrary.org/obo/MP_0000267 abnormal heart development any structural anomaly of the common canal connecting the primordial atrium and ventricle during fetal development; the dorsal and ventral endocardial cushions develop in the walls of the common atrioventricular canal, grow toward each other and fuse, dividing the common atrioventricular canal into right and left atrioventricular canals and the atrioventricular septum http://purl.obolibrary.org/obo/MP_0006108 abnormal hindbrain development http://purl.obolibrary.org/obo/MP_0000913 abnormal brain development anomaly in the formation or pattering of the caudal region of the brain http://purl.obolibrary.org/obo/MP_0006111 abnormal coronary circulation http://purl.obolibrary.org/obo/MP_0002128 abnormal blood circulation any anomaly in the circulation of blood through the vessels that supply the heart http://purl.obolibrary.org/obo/MP_0006113 abnormal heart septum morphology http://purl.obolibrary.org/obo/MP_0000266 abnormal heart morphology any structural anomaly of the thin membranous structure between the two heart atria, the atria and the ventricles, or the thick muscular structure between the two heart ventricles http://purl.obolibrary.org/obo/MP_0006135 artery stenosis http://purl.obolibrary.org/obo/MP_0005412 vascular stenosis abnormal narrowing of the arteries http://purl.obolibrary.org/obo/MP_0006141 abnormal atrioventricular node conduction http://purl.obolibrary.org/obo/MP_0003137 abnormal impulse conducting system conduction anomaly in the generation or transfer of cardiac electrical impulses from the atrioventricular node to the atrioventricular bundle http://purl.obolibrary.org/obo/MP_0006142 abnormal sinoatrial node conduction http://purl.obolibrary.org/obo/MP_0003137 abnormal impulse conducting system conduction anomaly in the generation or transfer of electrical impulses that trigger contraction of the atria and ventricles http://purl.obolibrary.org/obo/MP_0006276 abnormal autonomic nervous system physiology http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology any functional anomaly of the function of the sensory and motor neurons that run between the central nervous system (especially the hypothalamus and medulla oblongata) and various internal organs (heart, lungs, endocrine and exocrine glands), responsible for controlling involuntary bodily functions http://purl.obolibrary.org/obo/MP_0006279 abnormal limb development http://purl.obolibrary.org/obo/MP_0002109 abnormal limb morphology anomaly in the formation of the limbs http://purl.obolibrary.org/obo/MP_0006281 abnormal tail development http://purl.obolibrary.org/obo/MP_0002111 abnormal tail morphology anomaly in the formation of the tail http://purl.obolibrary.org/obo/MP_0006307 abnormal seminiferous tubule size http://purl.obolibrary.org/obo/MP_0002216 abnormal seminiferous tubule morphology alteration in the diameter of the tubules in the testes where spermatogenesis occurs http://purl.obolibrary.org/obo/MP_0006315 abnormal urine protein level http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis anomaly in the amount of protein in the urine http://purl.obolibrary.org/obo/MP_0006325 impaired hearing http://purl.obolibrary.org/obo/MP_0001963 abnormal hearing physiology reduced ability to perceive auditory stimuli http://purl.obolibrary.org/obo/MP_0006335 abnormal hearing electrophysiology http://purl.obolibrary.org/obo/MP_0001963 abnormal hearing physiology anomaly in auditory function as it relates to electrical phenomena http://purl.obolibrary.org/obo/MP_0006346 small pharyngeal arch http://purl.obolibrary.org/obo/MP_0002884 abnormal pharyngeal arch morphology reduced size of one or more of the branchial arches http://purl.obolibrary.org/obo/MP_0006357 abnormal circulating mineral level http://purl.obolibrary.org/obo/MP_0009642 abnormal blood homeostasis any anomaly in the concentration in the blood of any naturally occurring, homogeneous inorganic solid substance having a definite chemical composition and highly ordered atomic arrangement that is required for growth and survival http://purl.obolibrary.org/obo/MP_0006361 abnormal female germ cell morphology http://purl.obolibrary.org/obo/MP_0002208 abnormal germ cell morphology any structural anomaly female germ cells whether they are undifferentiated or fully differentiated http://purl.obolibrary.org/obo/MP_0006387 abnormal T cell number http://purl.obolibrary.org/obo/MP_0008037 abnormal T cell morphology deviation from the normal count of T cells http://purl.obolibrary.org/obo/MP_0006390 abnormal cochlear endolymph http://purl.obolibrary.org/obo/MP_0004885 abnormal endolymph change in the normal production (volume) or ionic homeostasis of the fluid contained within the cochlea of the inner ear http://purl.obolibrary.org/obo/MP_0006395 abnormal epiphyseal plate morphology http://purl.obolibrary.org/obo/MP_0002113 abnormal skeleton development any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development http://purl.obolibrary.org/obo/MP_0006404 abnormal lumbar dorsal root ganglion morphology http://purl.obolibrary.org/obo/MP_0000961 abnormal dorsal root ganglion morphology any structural anomaly of the group of nerve cell bodies located on the dorsal spinal roots within the vertebral column at the level of the lumbar vertebrae http://purl.obolibrary.org/obo/MP_0008000 increased ovary tumor incidence http://purl.obolibrary.org/obo/MP_0009590 increased gonad tumor incidence greater than the expected number of neoplams in the ovary occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0008011 intestine polyps http://purl.obolibrary.org/obo/MP_0010352 gastrointestinal tract polyps abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine http://purl.obolibrary.org/obo/MP_0008014 increased lung tumor incidence http://purl.obolibrary.org/obo/MP_0010298 increased respiratory system tumor incidence greater than the expected number of neoplasms in the lung, usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0008018 increased facial tumor incidence http://purl.obolibrary.org/obo/MP_0010293 increased integument system tumor incidence greater than the expected number of neoplasms on the face, usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0008019 increased liver tumor incidence http://purl.obolibrary.org/obo/MP_0010297 increased hepatobiliary system tumor incidence greater than the expected number of neoplasms in the liver, usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0008021 increased blastoma incidence http://purl.obolibrary.org/obo/MP_0002018 increased malignant tumor incidence higher than normal incidence of a fast growing and invasive tumor composed chiefly or entirely of immature undifferentiated cells that have embryonic characteristics resembling the primordium of the organ in which the tumor arose http://purl.obolibrary.org/obo/MP_0008022 dilated heart ventricle http://purl.obolibrary.org/obo/MP_0005294 abnormal heart ventricle morphology the luminal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid http://purl.obolibrary.org/obo/MP_0008026 abnormal brain white matter morphology http://purl.obolibrary.org/obo/MP_0002152 abnormal brain morphology any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites http://purl.obolibrary.org/obo/MP_0008031 decreased Cajal-Retzius cell number http://purl.obolibrary.org/obo/MP_0008030 abnormal Cajal-Retzius cell morphology reduced number of the distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus http://purl.obolibrary.org/obo/MP_0008037 abnormal T cell morphology http://purl.obolibrary.org/obo/MP_0002619 abnormal lymphocyte morphology any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation http://purl.obolibrary.org/obo/MP_0008052 abnormal serous gland morphology http://purl.obolibrary.org/obo/MP_0002163 abnormal gland morphology any structural anomaly of glands that secrete watery albuminous material that often contains enzymes http://purl.obolibrary.org/obo/MP_0008056 abnormal retinal ganglion cell morphology http://purl.obolibrary.org/obo/MP_0005241 abnormal retinal ganglion layer morphology any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain http://purl.obolibrary.org/obo/MP_0008075 decreased CD4-positive, alpha beta T cell number http://purl.obolibrary.org/obo/MP_0012765 decreased alpha-beta T cell number reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production http://purl.obolibrary.org/obo/MP_0008079 decreased CD8-positive, alpha-beta T cell number http://purl.obolibrary.org/obo/MP_0012765 decreased alpha-beta T cell number reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions http://purl.obolibrary.org/obo/MP_0008111 abnormal granulocyte differentiation http://purl.obolibrary.org/obo/MP_0005076 abnormal cell differentiation atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils http://purl.obolibrary.org/obo/MP_0008171 abnormal mature B cell morphology http://purl.obolibrary.org/obo/MP_0008195 abnormal professional antigen presenting cell morphology any structural anomaly of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex http://purl.obolibrary.org/obo/MP_0008186 increased pro-B cell number http://purl.obolibrary.org/obo/MP_0005432 abnormal pro-B cell morphology greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs http://purl.obolibrary.org/obo/MP_0008195 abnormal professional antigen presenting cell morphology http://purl.obolibrary.org/obo/MP_0000716 abnormal immune system cell morphology any structural anomaly of a cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response http://purl.obolibrary.org/obo/MP_0008209 decreased pre-B cell number http://purl.obolibrary.org/obo/MP_0005017 decreased B cell number reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface http://purl.obolibrary.org/obo/MP_0008213 absent immature B cells http://purl.obolibrary.org/obo/MP_0008215 decreased immature B cell number absence of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity http://purl.obolibrary.org/obo/MP_0008219 abnormal dorsal telencephalic commissure morphology http://purl.obolibrary.org/obo/MP_0002199 abnormal brain commissure morphology any structural anomaly of the fiber tracts that connect the dorsal region of the two cerebral hemispheres and span the longitudinal fissure, including the corpus callosum and hippocampal commissure http://purl.obolibrary.org/obo/MP_0008246 abnormal leukocyte morphology http://purl.obolibrary.org/obo/MP_0002123 abnormal hematopoiesis any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue http://purl.obolibrary.org/obo/MP_0008247 abnormal mononuclear cell morphology http://purl.obolibrary.org/obo/MP_0008246 abnormal leukocyte morphology any structural anomaly of a leukocyte with a single non-segmented nucleus in the mature form http://purl.obolibrary.org/obo/MP_0008248 abnormal mononuclear phagocyte morphology http://purl.obolibrary.org/obo/MP_0008251 abnormal phagocyte morphology any structural anomaly of a vertebrate phagocyte with a single nucleus http://purl.obolibrary.org/obo/MP_0008250 abnormal myeloid leukocyte morphology http://purl.obolibrary.org/obo/MP_0008246 abnormal leukocyte morphology any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage http://purl.obolibrary.org/obo/MP_0008271 abnormal bone ossification http://purl.obolibrary.org/obo/MP_0001533 abnormal skeleton physiology any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance http://purl.obolibrary.org/obo/MP_0008272 abnormal endochondral bone ossification http://purl.obolibrary.org/obo/MP_0008271 abnormal bone ossification anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone http://purl.obolibrary.org/obo/MP_0008273 abnormal intramembranous bone ossification http://purl.obolibrary.org/obo/MP_0008271 abnormal bone ossification anomaly in the process of the formation of bone in which osteoblasts secrete a collage-proteoglycan matrix that binds calcium salts and becomes calcified; intramembranous ossification is the way flat bones are formed http://purl.obolibrary.org/obo/MP_0008289 abnormal adrenal medulla morphology http://purl.obolibrary.org/obo/MP_0000639 abnormal adrenal gland morphology any structural anomaly of the inner portion of the adrenal gland that consists mainly of chromaffin cells which produce, store and secrete neurotransmitters such as epinephrine and norepinephrine http://purl.obolibrary.org/obo/MP_0008291 abnormal adrenocortical cell morphology http://purl.obolibrary.org/obo/MP_0008288 abnormal adrenal cortex morphology any structural anomaly of the steroid hormone-producing cells of the cortex of the adrenal gland http://purl.obolibrary.org/obo/MP_0008304 abnormal organ of Corti supporting cell differentiation http://purl.obolibrary.org/obo/MP_0005076 abnormal cell differentiation atypical production of or inability to produce the highly differentiated epithelial cells with distinctive morphological features that surround the hair cells in the organ of Corti http://purl.obolibrary.org/obo/MP_0008316 abnormal prevertebral ganglion morphology http://purl.obolibrary.org/obo/MP_0001008 abnormal sympathetic ganglion morphology any structural anomaly of the sympathetic ganglia located in front of the vertebral column and are associated with the major branches of the abdominal aorta; these include the celiac, aorticorenal, superior and inferior mesenteric ganglia http://purl.obolibrary.org/obo/MP_0008317 abnormal paravertebral ganglion morphology http://purl.obolibrary.org/obo/MP_0001008 abnormal sympathetic ganglion morphology any structural anomaly of the groups of postsynaptic neurons located at intervals along the sympatheic trunk, including the superior cervical, middle cervical and stellate (cervicothoracic) ganglia as well as the thoracic, lumbar and sacral ganglia http://purl.obolibrary.org/obo/MP_0008463 abnormal peripheral lymph node morphology http://purl.obolibrary.org/obo/MP_0002339 abnormal lymph node morphology any structural anomaly of the lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes http://purl.obolibrary.org/obo/MP_0008472 abnormal spleen secondary B follicle morphology http://purl.obolibrary.org/obo/MP_0008470 abnormal spleen B cell follicle morphology any structural anomaly of the nodules of antigen-activated, differentiating B cells, follicular dendritic cells, antigen-presenting T cells and macrophages in the spleen white pulp http://purl.obolibrary.org/obo/MP_0008487 abnormal mesonephros morphology http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology any structural anomaly of the excretory organ of the embryo, collective Wolffian tubules, which forms the urogenital fold from which the reproductive organs develop http://purl.obolibrary.org/obo/MP_0008488 abnormal semicircular canal ampulla morphology http://purl.obolibrary.org/obo/MP_0002428 abnormal semicircular canal morphology any structural anomaly of the spherical enlargement at the base of each semicircular canal where they connect with the utricle, containing the crista ampullaris which detects movement of the fluid within the canals http://purl.obolibrary.org/obo/MP_0008503 abnormal spinal cord grey matter morphology http://purl.obolibrary.org/obo/MP_0000955 abnormal spinal cord morphology any structural anomaly of the ridge-shaped grey matter of the spinal cord that extends longitudinally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue http://purl.obolibrary.org/obo/MP_0008504 abnormal adrenal chromaffin cell morphology http://purl.obolibrary.org/obo/MP_0010913 abnormal neuroendocrine cell morphology any structural anomaly of the neuroendocrine cells of the medulla of the adrenal gland that are innervated by the splanchnic nerve and that are responsible for epinephrine and norepinephrine secretion http://purl.obolibrary.org/obo/MP_0008540 abnormal cerebrum morphology http://purl.obolibrary.org/obo/MP_0000787 abnormal telencephalon morphology any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities http://purl.obolibrary.org/obo/MP_0008716 increased lung non-small cell carcinoma incidence http://purl.obolibrary.org/obo/MP_0008714 increased lung carcinoma incidence greater than the expected number of a heterogeneous aggregate of at least three distinct histological types of lung cancer, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0008779 abnormal maternal behavior http://purl.obolibrary.org/obo/MP_0002068 abnormal parental behavior any response from the mother or attending female related to the ability of young to thrive http://purl.obolibrary.org/obo/MP_0008797 facial cleft http://purl.obolibrary.org/obo/MP_0003743 abnormal facial morphology a cleft resulting from incomplete merging or fusion of any of the embryonic facial processes that normally unite to form the face http://purl.obolibrary.org/obo/MP_0008801 abnormal erythroid progenitor cell morphology http://purl.obolibrary.org/obo/MP_0002398 abnormal bone marrow cell morphology/development any structural anomaly of a progenitor cell committed to the erythroid lineage http://purl.obolibrary.org/obo/MP_0008813 decreased common myeloid progenitor cell number http://purl.obolibrary.org/obo/MP_0006410 abnormal common myeloid progenitor cell morphology reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages http://purl.obolibrary.org/obo/MP_0008840 abnormal spike wave discharge http://purl.obolibrary.org/obo/MP_0003216 absence seizures anomaly in the characteristic epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy http://purl.obolibrary.org/obo/MP_0008866 chromosomal instability http://purl.obolibrary.org/obo/MP_0010094 abnormal chromosome stability abnormalities of DNA metabolism, DNA repair, cell-cycle governance, or control of apoptosis that increase the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity http://purl.obolibrary.org/obo/MP_0008868 abnormal granulosa cell morphology http://purl.obolibrary.org/obo/MP_0001131 abnormal ovarian follicle morphology any structural anomaly of a supporting cell for the developing female gamete in the ovary of mammals; granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle http://purl.obolibrary.org/obo/MP_0008871 abnormal ovarian follicle number http://purl.obolibrary.org/obo/MP_0001131 abnormal ovarian follicle morphology abnormal numbers of spheroid cell aggregations in the ovary http://purl.obolibrary.org/obo/MP_0008898 abnormal acrosome morphology http://purl.obolibrary.org/obo/MP_0009230 abnormal sperm head morphology any structural anomaly of the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration http://purl.obolibrary.org/obo/MP_0008911 induced hyperactivity http://purl.obolibrary.org/obo/MP_0001399 hyperactivity increased physical activity following stimulation such as handling, touching or noise http://purl.obolibrary.org/obo/MP_0008936 abnormal pituitary gland size http://purl.obolibrary.org/obo/MP_0000633 abnormal pituitary gland morphology anomaly in the average size of the compound gland suspended from the base of the hypothalamus http://purl.obolibrary.org/obo/MP_0008943 increased sensitivity to induced cell death http://purl.obolibrary.org/obo/MP_0008942 abnormal induced cell death decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level http://purl.obolibrary.org/obo/MP_0008944 decreased sensitivity to induced cell death http://purl.obolibrary.org/obo/MP_0008942 abnormal induced cell death increase in the exposure level to an agent that is required to induce cessation of function at the cellular level http://purl.obolibrary.org/obo/MP_0008947 increased neuron number http://purl.obolibrary.org/obo/MP_0008946 abnormal neuron number greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses http://purl.obolibrary.org/obo/MP_0008948 decreased neuron number http://purl.obolibrary.org/obo/MP_0008946 abnormal neuron number fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses http://purl.obolibrary.org/obo/MP_0008957 abnormal placenta junctional zone morphology http://purl.obolibrary.org/obo/MP_0001711 abnormal placenta morphology any structural anomaly of the fetally derived placental region that separates the maternal uterine tissue from the placenta labyrinth http://purl.obolibrary.org/obo/MP_0008968 abnormal lacrimal apparatus morphology http://purl.obolibrary.org/obo/MP_0002092 abnormal eye morphology any structural anomaly of the network of orbital structures of the eye that secrete and drain tears from the surface of the eyeball into the nasal cavity; these parts include the lacrimal glands, lacrimal lake, lacrimal ducts, lacrimal canals, lacrimal sacs, nasolacrimal ducts, and lacrimal puncta http://purl.obolibrary.org/obo/MP_0008973 decreased erythroid progenitor cell number http://purl.obolibrary.org/obo/MP_0008801 abnormal erythroid progenitor cell morphology reduced numbers of progenitors of the erythrocyte lineage http://purl.obolibrary.org/obo/MP_0008987 abnormal liver lobule morphology http://purl.obolibrary.org/obo/MP_0008986 abnormal liver parenchyma morphology any structural anomaly of the polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein http://purl.obolibrary.org/obo/MP_0008989 abnormal liver sinusoid morphology http://purl.obolibrary.org/obo/MP_0009820 abnormal liver vasculature morphology any structural anomaly of the hepatic distensible vascular blood channels lined with highly fenestrated endothelial cells that function to exchange fluids, nutrients, proteins and wastes http://purl.obolibrary.org/obo/MP_0009043 increased pancreas adenoma incidence http://purl.obolibrary.org/obo/MP_0009153 increased pancreas tumor incidence greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the pancreas, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0009046 muscle twitch http://purl.obolibrary.org/obo/MP_0002106 abnormal muscle physiology minor, sometimes imperceptible, local muscle contractions or uncontrollable movement of a single muscle group served by a single motor nerve fiber or filament sometime, but not always, indicating a neurological disorder http://purl.obolibrary.org/obo/MP_0009053 abnormal anal canal morphology http://purl.obolibrary.org/obo/MP_0000462 abnormal digestive system morphology any structural anomaly in the terminal portion of the alimentary canal, which begins at the anorectal junction, where the rectal ampulla abruptly narrows as the alimentary canal pierces the pelvic diaphragm (levator ani), and ends at the anal verge, when the anoderm that lines the lower anal canal changes to hairy perianal skin; surrounded by the internal and external anal sphincters http://purl.obolibrary.org/obo/MP_0009070 small oviduct http://purl.obolibrary.org/obo/MP_0009063 abnormal oviduct size reduced size of the tube through which the ova pass from the ovary to the uterus http://purl.obolibrary.org/obo/MP_0009100 abnormal clitoris size http://purl.obolibrary.org/obo/MP_0003127 abnormal clitoris morphology anomaly in the size of the small cylindrical erectile body located at the most anterior portion of the vulva http://purl.obolibrary.org/obo/MP_0009102 abnormal glans penis morphology http://purl.obolibrary.org/obo/MP_0005187 abnormal penis morphology any structural anomaly of the conic expansion of the corpus spongiosum that forms the head of the penis http://purl.obolibrary.org/obo/MP_0009106 abnormal pancreas size http://purl.obolibrary.org/obo/MP_0001944 abnormal pancreas morphology anomaly in the average size of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream http://purl.obolibrary.org/obo/MP_0009110 pancreas hyperplasia http://purl.obolibrary.org/obo/MP_0003450 enlarged pancreas overdevelopment or increased size of the pancreas, usually due an increased number of cells http://purl.obolibrary.org/obo/MP_0009199 abnormal external male genitalia morphology http://purl.obolibrary.org/obo/MP_0009198 abnormal male genitalia morphology any structural anomaly of the external masculine genital organs, including the penis and scrotum http://purl.obolibrary.org/obo/MP_0009205 abnormal internal male genitalia morphology http://purl.obolibrary.org/obo/MP_0009198 abnormal male genitalia morphology any structural anomaly of the internal masculine genital organs, including the testes, epididymides, deferent ducts, seminal vesicles, prostate, ejaculatory ducts, and bulbourethral glands http://purl.obolibrary.org/obo/MP_0009208 abnormal female genitalia morphology http://purl.obolibrary.org/obo/MP_0001119 abnormal female reproductive system morphology any structural anomaly of the feminine organs of reproduction or generation, external or internal http://purl.obolibrary.org/obo/MP_0009209 abnormal internal female genitalia morphology http://purl.obolibrary.org/obo/MP_0009208 abnormal female genitalia morphology any structural anomaly of the internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina http://purl.obolibrary.org/obo/MP_0009222 increased uterus tumor incidence http://purl.obolibrary.org/obo/MP_0010287 increased reproductive system tumor incidence greater than the expected number of abnormal rapidly proliferating cells in the uterus, usually in the form of a distinct mass, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0009250 abnormal appendicular skeleton morphology http://purl.obolibrary.org/obo/MP_0005508 abnormal skeleton morphology any structural anomaly of the bones of the limbs, shoulder and pelvic girdles http://purl.obolibrary.org/obo/MP_0009308 increased adenocarcinoma incidence http://purl.obolibrary.org/obo/MP_0002038 increased carcinoma incidence higher than normal incidence of a malignant neoplasm of epithelial cells in a glandular or glandular-like pattern http://purl.obolibrary.org/obo/MP_0009344 abnormal ovulation cycle http://purl.obolibrary.org/obo/MP_0003699 abnormal female reproductive system physiology any anomaly in the type of sexual cycle seen in female mammals, with physiologic changes in the endometrium that recur at regular intervals during the reproductive years http://purl.obolibrary.org/obo/MP_0009357 abnormal seizure response to inducing agent http://purl.obolibrary.org/obo/MP_0002064 seizures anomaly in the seizure activity response to an agent that normally can induce uncontrolled electrical activity in the brain, producing a physical convulsion and/or minor change in physical behavior http://purl.obolibrary.org/obo/MP_0009358 environmentally induced seizures http://purl.obolibrary.org/obo/MP_0009357 abnormal seizure response to inducing agent seizure activity response due to changes in ambient habitat including room temperature, lighting, sounds, touching, and/ or moving cage http://purl.obolibrary.org/obo/MP_0009364 abnormal mature ovarian follicle morphology http://purl.obolibrary.org/obo/MP_0001131 abnormal ovarian follicle morphology any structural anomaly in the ovarian follicle that is ready for ovulation and presents a blanched spot (the follicular stigma) where the graafian follicle is about to rupture on the surface of the ovary; a first maturation (meiotic) division of the primary oocyte usually occurs just prior to rupture of the follicle http://purl.obolibrary.org/obo/MP_0009379 abnormal foot pigmentation http://purl.obolibrary.org/obo/MP_0002095 abnormal skin pigmentation anomaly in the coloration of the foot due to changes in the amount, shape, or distribution of cells producing pigment http://purl.obolibrary.org/obo/MP_0009380 abnormal prostate gland ventral lobe morphology http://purl.obolibrary.org/obo/MP_0001158 abnormal prostate gland morphology any structural anomaly of the rodent prostate lobe that is located below the ventral aspect of the bladder neck http://purl.obolibrary.org/obo/MP_0009389 abnormal extracutaneous pigmentation http://purl.obolibrary.org/obo/MP_0001186 pigmentation phenotype anomaly in the coloration of organs and tissues excluding the integument due to changes in the amount, shape, or distribution of cells producing pigment http://purl.obolibrary.org/obo/MP_0009419 skeletal muscle fibrosis http://purl.obolibrary.org/obo/MP_0000759 abnormal skeletal muscle morphology formation of fibrous tissue within skeletal muscle as a result of repair or a reactive process http://purl.obolibrary.org/obo/MP_0009458 abnormal skeletal muscle size http://purl.obolibrary.org/obo/MP_0004817 abnormal skeletal muscle mass anomaly in the size of the striated muscle fibers connected at either or both extremities with the bony framework of the body http://purl.obolibrary.org/obo/MP_0009469 increased skin hamartoma incidence http://purl.obolibrary.org/obo/MP_0010306 increased hamartoma incidence greater than the expected number of a benign formation of a mass of tissue of disproportionate size and distribution in the skin, but composed of an overgrowth of mature cells and tissues that normally occur in this tissue, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0009503 abnormal mammary gland duct morphology http://purl.obolibrary.org/obo/MP_0000627 abnormal mammary gland morphology any structural anomaly of the canals that lead from the lobes of the mammary gland to the tip of the nipple and are responsible for carrying milk toward the nipple in a lactating female http://purl.obolibrary.org/obo/MP_0009506 abnormal mammary gland alveolus morphology http://purl.obolibrary.org/obo/MP_0009505 abnormal mammary gland lobule morphology any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy http://purl.obolibrary.org/obo/MP_0009517 abnormal salivary gland duct morphology http://purl.obolibrary.org/obo/MP_0000613 abnormal salivary gland morphology any structural anomaly of the tubular canals that carry saliva http://purl.obolibrary.org/obo/MP_0009538 abnormal synapse morphology http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology any structural anomaly of the membrane junction site of a nerve cell to a target cell, such as another nerve cell, an effector cell, or a sensory receptor cell; transmission of nerve impulses may be mediated by chemical or by electrical means http://purl.obolibrary.org/obo/MP_0009544 abnormal thymus epithelium morphology http://purl.obolibrary.org/obo/MP_0000703 abnormal thymus morphology any structural anomaly of the supporting framework of the thymus http://purl.obolibrary.org/obo/MP_0009545 abnormal dermis papillary layer morphology http://purl.obolibrary.org/obo/MP_0001243 abnormal dermal layer morphology any structural anomaly of the more superficial, thin layer of the dermis that interdigitates with the epidermis http://purl.obolibrary.org/obo/MP_0009566 meiotic nondisjunction http://purl.obolibrary.org/obo/MP_0001930 abnormal meiosis failure of homologous chromosomes to separate to the cell poles at anaphase http://purl.obolibrary.org/obo/MP_0009569 abnormal left lung morphology http://purl.obolibrary.org/obo/MP_0001175 abnormal lung morphology any structural anomaly of the organ of respiration located on the left side of the body http://purl.obolibrary.org/obo/MP_0009570 abnormal right lung morphology http://purl.obolibrary.org/obo/MP_0001175 abnormal lung morphology any structural anomaly of the part of the organ of respiration located on the right side of the body and consists of the caudal, cranial, middle and accessory lobes http://purl.obolibrary.org/obo/MP_0009577 abnormal developmental vascular remodeling http://purl.obolibrary.org/obo/MP_0000260 abnormal angiogenesis any anomaly in the process by which existing vessels are reorganized during development http://purl.obolibrary.org/obo/MP_0009611 epidermis stratum spinosum hyperplasia http://purl.obolibrary.org/obo/MP_0001236 abnormal epidermis stratum spinosum morphology overdevelopment or increased size, usually due an increased number of cells, of the layer of polyhedral cells in the epidermis; shrinkage and adhesion of these cells gives a spiny or prickly appearance http://purl.obolibrary.org/obo/MP_0009641 kidney degeneration http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology a retrogressive impairment of function or destruction of either or both of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine http://purl.obolibrary.org/obo/MP_0009642 abnormal blood homeostasis http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis http://purl.obolibrary.org/obo/MP_0005502 abnormal renal/urinary system physiology anomaly in the processes involved in the maintenance of an internal equilibrium of the various chemical or protein components of the urine http://purl.obolibrary.org/obo/MP_0009661 abnormal pregnancy http://purl.obolibrary.org/obo/MP_0003699 abnormal female reproductive system physiology any anomaly in the process of maintaining a developing embryo or fetus within the female body from conception to birth http://purl.obolibrary.org/obo/MP_0009676 abnormal hemostasis http://purl.obolibrary.org/obo/MP_0009642 abnormal blood homeostasis any anomaly in the spontaneous arrest of bleeding from vessels carrying blood under pressure or the arrest of circulation to an organ or part http://purl.obolibrary.org/obo/MP_0009697 abnormal copulation http://purl.obolibrary.org/obo/MP_0001919 abnormal reproductive system physiology an anomaly in sexual union that normally enables the transfer of ejaculate (sperm) from male to female, sometimes resulting in the fertilization of an egg http://purl.obolibrary.org/obo/MP_0009731 abnormal offspring retrieval http://purl.obolibrary.org/obo/MP_0001386 abnormal maternal nurturing any anomaly in the ability of a female to collect stray offspring and return them to a defined location, such as a nest or den http://purl.obolibrary.org/obo/MP_0009734 abnormal prostate gland duct morphology http://purl.obolibrary.org/obo/MP_0001158 abnormal prostate gland morphology any structural anomaly of the minute canals that pass the prostatic secretions to the urethra http://purl.obolibrary.org/obo/MP_0009736 abnormal prostate gland branching morphogenesis http://purl.obolibrary.org/obo/MP_0009735 abnormal prostate gland development anomaly of the prostatic bud to repeatedly divide into lobules during development of the prostate gland http://purl.obolibrary.org/obo/MP_0009745 abnormal behavioral response to xenobiotic http://purl.obolibrary.org/obo/MP_0004924 abnormal behavior any anomaly in the behavioral response induced by a foreign compound, such as consumption preference, induced hyperactivity or stereotypic behavior http://purl.obolibrary.org/obo/MP_0009751 enhanced behavioral response to alcohol http://purl.obolibrary.org/obo/MP_0020157 abnormal behavioral response to alcohol increased sensitivity to alcohol resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response http://purl.obolibrary.org/obo/MP_0009764 decreased sensitivity to induced morbidity/mortality http://purl.obolibrary.org/obo/MP_0020148 abnormal sensitivity to induced morbidity/mortality increase in the amount of an external agent required to cause death or diseased state http://purl.obolibrary.org/obo/MP_0009768 impaired somite development http://purl.obolibrary.org/obo/MP_0001688 abnormal somite development atypical process of somite formation with the result of fewer or none of these cell masses being formed http://purl.obolibrary.org/obo/MP_0009781 abnormal preimplantation embryo development http://purl.obolibrary.org/obo/MP_0001672 abnormal embryogenesis/ development an anomaly in the developmental progress of an embryo from 2 cell to blastocyst affecting the viability or number of embryos http://purl.obolibrary.org/obo/MP_0009800 abnormal mandibular nerve morphology http://purl.obolibrary.org/obo/MP_0001065 abnormal trigeminal nerve morphology any structural anomaly of the motor and sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the auricle, the external acoustic meatus, tympanic membrane, temporal region, the cheek, the skin overlying the mandible, the anterior portion of the tongue, the floor of the mouth, lower teeth and gingiva and transmits motor information from the muscles of mastication, the mylohyoid muscle and digastric muscle and the muscles tensor tympani and tensor veli palatini http://purl.obolibrary.org/obo/MP_0009806 abnormal otic vesicle morphology http://purl.obolibrary.org/obo/MP_0003938 abnormal ear development any structural anomaly of the paired sacs of invaginated ectoderm that develop into the membraneous labyrinth of the inner ear http://purl.obolibrary.org/obo/MP_0009808 decreased oligodendrocyte number http://purl.obolibrary.org/obo/MP_0000953 abnormal oligodendrocyte morphology reduced number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS http://purl.obolibrary.org/obo/MP_0009819 abnormal circulating androgen level http://purl.obolibrary.org/obo/MP_0005418 abnormal circulating hormone level anomaly in the blood concentration of any of the steroid hormones that control development and maintenance of masculine characteristics http://purl.obolibrary.org/obo/MP_0009858 abnormal cellular extravasation http://purl.obolibrary.org/obo/MP_0003156 abnormal leukocyte migration any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue http://purl.obolibrary.org/obo/MP_0009862 abnormal aorta elastic tissue morphology http://purl.obolibrary.org/obo/MP_0009873 abnormal aorta tunica media morphology any structural anomaly of the dense connective tissue which contains predominantly elastic fibers and is found in the tunica media of the aorta wall http://purl.obolibrary.org/obo/MP_0009863 abnormal heart elastic tissue morphology http://purl.obolibrary.org/obo/MP_0003974 abnormal endocardium morphology any structural anomaly of the type of heart connective tissue found in the endocardial layer that consists mainly of elastic fibers http://purl.obolibrary.org/obo/MP_0009931 abnormal skin appearance http://purl.obolibrary.org/obo/MP_0002060 abnormal skin morphology anomaly in the visual aspect of the skin http://purl.obolibrary.org/obo/MP_0009937 abnormal neuron differentiation http://purl.obolibrary.org/obo/MP_0005076 abnormal cell differentiation abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses http://purl.obolibrary.org/obo/MP_0009939 abnormal hippocampus neuron morphology http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology any structural anomaly of one or more neurons residing in the hippocampal region of the brain http://purl.obolibrary.org/obo/MP_0009956 abnormal cerebellar layer morphology http://purl.obolibrary.org/obo/MP_0004097 abnormal cerebellar cortex morphology any structural anomaly of the laminar structure of the cerebellar cortex comprising the gray matter of the cerebellum http://purl.obolibrary.org/obo/MP_0009960 abnormal cerebellum anterior lobe morphology http://purl.obolibrary.org/obo/MP_0004097 abnormal cerebellar cortex morphology any structural anomaly of the region of the cerebellum that is anterior to the primary fissure http://purl.obolibrary.org/obo/MP_0009962 abnormal cerebellum posterior lobe morphology http://purl.obolibrary.org/obo/MP_0004097 abnormal cerebellar cortex morphology any structural anomaly of the region of the cerebellum that is posterior to the primary fissure and anterior to the posteriolateral fissure http://purl.obolibrary.org/obo/MP_0009964 abnormal cerebellum lobule morphology http://purl.obolibrary.org/obo/MP_0004097 abnormal cerebellar cortex morphology any structural anomaly of the ten gyri of the cerebellar cortex http://purl.obolibrary.org/obo/MP_0010017 visceral vascular congestion http://purl.obolibrary.org/obo/MP_0000255 vasculature congestion obstruction of the normal flux of blood within the blood vessel network of the internal organs enclosed within the cavity of the body, such as the thoracic, abdominal, endocrine, and pelvic organs http://purl.obolibrary.org/obo/MP_0010028 aciduria http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis excretion of an acid urine http://purl.obolibrary.org/obo/MP_0010029 abnormal basicranium morphology http://purl.obolibrary.org/obo/MP_0000438 abnormal cranium morphology any structural anomaly of the sloping floor of the cranial cavity that is comprised of parts of the ethmoidal, occipital and sphenoid bones http://purl.obolibrary.org/obo/MP_0010031 abnormal cranium size http://purl.obolibrary.org/obo/MP_0000438 abnormal cranium morphology deviation from the average range of cranium size compared to normal http://purl.obolibrary.org/obo/MP_0010038 abnormal placenta physiology http://purl.obolibrary.org/obo/MP_0004264 abnormal extraembryonic tissue physiology any functional anomaly of the organ of metabolic interchange between fetus and mother, which is partly of embryonic origin and partly of maternal origin http://purl.obolibrary.org/obo/MP_0010055 abnormal sensory neuron physiology http://purl.obolibrary.org/obo/MP_0005423 abnormal somatic nervous system physiology any functional anomaly of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of sensory impulses http://purl.obolibrary.org/obo/MP_0010067 increased red blood cell distribution width http://purl.obolibrary.org/obo/MP_0010066 abnormal red blood cell distribution width higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism http://purl.obolibrary.org/obo/MP_0010080 abnormal hepatocyte physiology http://purl.obolibrary.org/obo/MP_0000609 abnormal liver physiology any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules http://purl.obolibrary.org/obo/MP_0010115 abnormal embryonic cloaca morphology http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology any structural anomaly of the endoderm-lined chamber that develops as pouch-like dilation of the caudal end of the hindgut and receives the allantois ventrally and two mesonephric ducts laterally; caudally it ends blindly at the cloacal membrane formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm http://purl.obolibrary.org/obo/MP_0010119 abnormal bone mineral density http://purl.obolibrary.org/obo/MP_0003795 abnormal bone structure anomaly in the amount of mineral per square centimeter of bone (usually g/cm2), used as a measure of structural strength and screen for osteoporosis; bone mineral density is the ratio of bone mineral content to bone size http://purl.obolibrary.org/obo/MP_0010147 abnormal endocrine pancreas physiology http://purl.obolibrary.org/obo/MP_0002693 abnormal pancreas physiology any functional anomaly of the smaller portion of the pancreas that secretes a number of hormones into the blood stream that are produced by the cells in the islets of Langerhans http://purl.obolibrary.org/obo/MP_0010148 abnormal exocrine pancreas physiology http://purl.obolibrary.org/obo/MP_0002693 abnormal pancreas physiology any functional anomaly of the acinar gland portion of the pancreas that secretes digestive enzymes http://purl.obolibrary.org/obo/MP_0010154 abnormal gastroesophageal sphincter physiology http://purl.obolibrary.org/obo/MP_0002106 abnormal muscle physiology any functional anomaly of the thick circular layer of gastric musculature encircling the gastroesophageal junction that functions to reduce backflow into the esophagus from the stomach http://purl.obolibrary.org/obo/MP_0010155 abnormal intestine physiology http://purl.obolibrary.org/obo/MP_0001663 abnormal digestive system physiology any functional anomaly of the digestive tube passing from the stomach to the anus http://purl.obolibrary.org/obo/MP_0010158 abnormal intestine development http://purl.obolibrary.org/obo/MP_0003119 abnormal digestive system development abnormal formation of the digestive tube passing from the stomach to the anus http://purl.obolibrary.org/obo/MP_0010163 hemolysis http://purl.obolibrary.org/obo/MP_0003656 abnormal erythrocyte physiology destruction of erythrocytes such that hemoglobin is released from the cells; may occur by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity http://purl.obolibrary.org/obo/MP_0010182 decreased susceptibility to weight gain http://purl.obolibrary.org/obo/MP_0011117 abnormal susceptibility to weight gain smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake http://purl.obolibrary.org/obo/MP_0010183 abnormal CD4-positive helper T cell morphology http://purl.obolibrary.org/obo/MP_0002432 abnormal CD4-positive, alpha beta T cell morphology any structural anomaly of a CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions http://purl.obolibrary.org/obo/MP_0010200 enlarged lymphatic vessel http://purl.obolibrary.org/obo/MP_0001879 abnormal lymphatic vessel morphology increased size of the network of vessels which carries lymph around the body http://purl.obolibrary.org/obo/MP_0010207 abnormal telomere morphology http://purl.obolibrary.org/obo/MP_0003702 abnormal chromosome morphology any structural anomaly of the terminal repetitive DNA section of a chromosome which is involved in chromosomal replication and senescence, and which protects the end of the chromosome from deterioration http://purl.obolibrary.org/obo/MP_0010273 increased classified tumor incidence http://purl.obolibrary.org/obo/MP_0020188 abnormal classified tumor incidence greater than the expected number of tumors with a specific classification type in a given population in a given time period http://purl.obolibrary.org/obo/MP_0010279 increased gastrointestinal tumor incidence http://purl.obolibrary.org/obo/MP_0010292 increased alimentary system tumor incidence greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period http://purl.obolibrary.org/obo/MP_0010280 increased skeletal tumor incidence http://purl.obolibrary.org/obo/MP_0010274 increased organ/body region tumor incidence greater than the expected number of neoplasms in the skeletal tissue, usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010281 increased nervous system tumor incidence http://purl.obolibrary.org/obo/MP_0010274 increased organ/body region tumor incidence greater than the expected number of tumors originating in the nervous system in a given population in a given time period http://purl.obolibrary.org/obo/MP_0010287 increased reproductive system tumor incidence http://purl.obolibrary.org/obo/MP_0010274 increased organ/body region tumor incidence greater than the expected number of tumors originating in the reproductive system in a given population in a given time period http://purl.obolibrary.org/obo/MP_0010288 increased gland tumor incidence http://purl.obolibrary.org/obo/MP_0010274 increased organ/body region tumor incidence greater than the expected number of tumors originating in a gland in a given population in a given time period http://purl.obolibrary.org/obo/MP_0010290 increased muscle tumor incidence http://purl.obolibrary.org/obo/MP_0010274 increased organ/body region tumor incidence greater than the expected number of tumors originating in muscle tissue in a given population in a given time period http://purl.obolibrary.org/obo/MP_0010291 increased cardiovascular system tumor incidence http://purl.obolibrary.org/obo/MP_0010274 increased organ/body region tumor incidence greater than the expected number of tumors originating in the cardiovascular system in a given population in a given time period http://purl.obolibrary.org/obo/MP_0010292 increased alimentary system tumor incidence http://purl.obolibrary.org/obo/MP_0010274 increased organ/body region tumor incidence greater than the expected number of tumors originating in the alimentary system in a given population in a given time period http://purl.obolibrary.org/obo/MP_0010294 increased kidney tumor incidence http://purl.obolibrary.org/obo/MP_0010289 increased urinary system tumor incidence greater than the expected number of tumors originating in the kidney in a given population in a given time period http://purl.obolibrary.org/obo/MP_0010296 increased hemolymphoid system tumor incidence http://purl.obolibrary.org/obo/MP_0010274 increased organ/body region tumor incidence greater than the expected number of tumors originating in the hemolymphoid system in a given population in a given time period http://purl.obolibrary.org/obo/MP_0010299 increased mammary gland tumor incidence http://purl.obolibrary.org/obo/MP_0010293 increased integument system tumor incidence greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010300 increased skin tumor incidence http://purl.obolibrary.org/obo/MP_0010293 increased integument system tumor incidence greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010306 increased hamartoma incidence http://purl.obolibrary.org/obo/MP_0010273 increased classified tumor incidence greater than the expected number of benign focal malformations in a specific population in a given time period; results from faulty development of an organ, and is composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element normally present at that site http://purl.obolibrary.org/obo/MP_0010316 increased thyroid tumor incidence http://purl.obolibrary.org/obo/MP_0010288 increased gland tumor incidence greater than the expected number of neoplams in the thyroid occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010318 increased salivary gland tumor incidence http://purl.obolibrary.org/obo/MP_0010288 increased gland tumor incidence greater than the expected number of neoplams in the salivary gland occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010320 increased pituitary gland tumor incidence http://purl.obolibrary.org/obo/MP_0010288 increased gland tumor incidence greater than the expected number of neoplams in the pituitary gland occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010321 increased parathyroid gland tumor incidence http://purl.obolibrary.org/obo/MP_0010288 increased gland tumor incidence greater than the expected number of neoplams in the parathyroid gland occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010324 abnormal malleus processus brevis morphology http://purl.obolibrary.org/obo/MP_0000029 abnormal malleus morphology any structural anomaly of the projection extending from the base of the manubrium of the malleus which contacts the upper part of the tympanic membrane where the tympanic cavity makes a deep pocket (epitympanic pocket) surrounding the cartilaginous nodule http://purl.obolibrary.org/obo/MP_0010330 abnormal circulating lipoprotein level http://purl.obolibrary.org/obo/MP_0010329 abnormal lipoprotein level any anomaly in the concentration in the blood of any complex or compound containing both lipid and protein, are important components of biological membranes and myelin, and participate in lipid transport http://purl.obolibrary.org/obo/MP_0010334 pleural effusion http://purl.obolibrary.org/obo/MP_0002133 abnormal respiratory system physiology accumulation of excess fluid in the pleural cavity http://purl.obolibrary.org/obo/MP_0010350 increased pituitary adenohypophysis tumor incidence http://purl.obolibrary.org/obo/MP_0010320 increased pituitary gland tumor incidence greater than the expected number of neoplasms in the anterior part of the pituitary that secretes a variety of hormones, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010352 gastrointestinal tract polyps http://purl.obolibrary.org/obo/MP_0000462 abnormal digestive system morphology abnormal tissue masses that protrude into the lumen of the gastrointestinal tract and are tethered to the wall of the gastrointestinal tract http://purl.obolibrary.org/obo/MP_0010358 abnormal free fatty acids level http://purl.obolibrary.org/obo/MP_0005280 abnormal fatty acid level any anomaly in the concentration of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues http://purl.obolibrary.org/obo/MP_0010363 increased fibrosarcoma incidence http://purl.obolibrary.org/obo/MP_0002032 increased sarcoma incidence greater than the expected number of a highly aggressive malignant neoplasm arising from fibrous connective tissue, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010365 increased thymus tumor incidence http://purl.obolibrary.org/obo/MP_0010288 increased gland tumor incidence greater than the expected number of neoplams in the thymus occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010368 abnormal lymphatic system physiology http://purl.obolibrary.org/obo/MP_0001790 abnormal immune system physiology any functional anomaly of the interconnected system of spaces, organs and vessels between body tissues and organs through which fluid, fats, proteins, and lymphocytes are transported to the bloodstream as lymph, and microorganisms and other debris are removed from tissues http://purl.obolibrary.org/obo/MP_0010383 increased adenoma incidence http://purl.obolibrary.org/obo/MP_0020189 abnormal adenoma incidence greater than the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy http://purl.obolibrary.org/obo/MP_0010386 abnormal urinary bladder physiology http://purl.obolibrary.org/obo/MP_0005502 abnormal renal/urinary system physiology any functional anomaly of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys http://purl.obolibrary.org/obo/MP_0010387 abnormal Bergmann glial cell morphology http://purl.obolibrary.org/obo/MP_0000875 abnormal cerebellar Purkinje cell layer any structural anomaly of one or more astrocyte-type glia cells associated with Purkinje cells in the cerebellum http://purl.obolibrary.org/obo/MP_0010426 abnormal heart and great artery attachment http://purl.obolibrary.org/obo/MP_0010425 abnormal heart and great vessel attachment any anomaly in the in the position or pattern of the connection site of the heart to any of the great arteries, including the pulmonary artery and aorta http://purl.obolibrary.org/obo/MP_0010428 abnormal heart right ventricle outflow tract morphology http://purl.obolibrary.org/obo/MP_0010224 abnormal heart ventricle outflow tract morphology any structural anomaly of the anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk http://purl.obolibrary.org/obo/MP_0010429 abnormal heart left ventricle outflow tract morphology http://purl.obolibrary.org/obo/MP_0010224 abnormal heart ventricle outflow tract morphology any structural anomaly of the anterosuperior fibrous portion of the left ventricle that connects to the ascending aorta http://purl.obolibrary.org/obo/MP_0010435 abnormal heart atrium and ventricle connection http://purl.obolibrary.org/obo/MP_0000266 abnormal heart morphology any anomaly in the in the position or pattern of the connection site of the heart atrium to the ventricles, usually occurring through the atrioventricular valves http://purl.obolibrary.org/obo/MP_0010454 abnormal truncus arteriosus septation http://purl.obolibrary.org/obo/MP_0006126 abnormal outflow tract development anomaly in the process of dividing the common arterial trunk arising out of both heart ventricles to divide into the aorta and pulmonary artery during development http://purl.obolibrary.org/obo/MP_0010465 aberrant origin of the right subclavian artery http://purl.obolibrary.org/obo/MP_0010487 abnormal right subclavian artery morphology the right subclavian artery arises from an atypical location on the aortic arch or the proximal descending aorta http://purl.obolibrary.org/obo/MP_0010466 vascular ring http://purl.obolibrary.org/obo/MP_0004113 abnormal aortic arch morphology the trachea and esophagus are completely encircled by connected segments of the aortic arch and its branches http://purl.obolibrary.org/obo/MP_0010468 abnormal thoracic aorta morphology http://purl.obolibrary.org/obo/MP_0000272 abnormal aorta morphology any structural anomaly of the part of the aorta that extends from the origin at the heart to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest http://purl.obolibrary.org/obo/MP_0010489 abnormal heart atrium auricular region morphology http://purl.obolibrary.org/obo/MP_0003105 abnormal heart atrium morphology any structural anomaly of the small conical pouch projections located on the upper anterior portion of each atrium of the heart http://purl.obolibrary.org/obo/MP_0010499 abnormal ventricle myocardium morphology http://purl.obolibrary.org/obo/MP_0005329 abnormal myocardium layer morphology any structural anomaly of the ventricular part of middle layer of the heart, comprised of involuntary muscle http://purl.obolibrary.org/obo/MP_0010502 ventricle myocardium hypoplasia http://purl.obolibrary.org/obo/MP_0010500 myocardium hypoplasia underdevelopment or reduced size, usually due to a reduced number of cells, of the ventricular part of the heart myocardium http://purl.obolibrary.org/obo/MP_0010503 myocardial trabeculae hypoplasia http://purl.obolibrary.org/obo/MP_0010500 myocardium hypoplasia underdevelopment or reduced size of the supporting bundles of muscular fibers lining the walls of the heart, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0010508 abnormal heart electrocardiography waveform feature http://purl.obolibrary.org/obo/MP_0003137 abnormal impulse conducting system conduction any anomaly in the pattern of the graphic record of the integrated action currents of the cardiac cycle represented as changes in voltage; the prominent waves in the ECG correspond to specific conduction activity in areas of the heart and the timing and amplitude of ECG waveforms provide valuable information about heart rate and rhythm http://purl.obolibrary.org/obo/MP_0010519 atrioventricular block http://purl.obolibrary.org/obo/MP_0010559 heart block a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles http://purl.obolibrary.org/obo/MP_0010520 sinoatrial block http://purl.obolibrary.org/obo/MP_0010559 heart block a partial or complete obstruction of the impulse leaving the sinoatrial node preventing it from activating atrial muscle http://purl.obolibrary.org/obo/MP_0010544 interrupted aorta http://purl.obolibrary.org/obo/MP_0000272 abnormal aorta morphology complete discontinuation or blockage in the aorta http://purl.obolibrary.org/obo/MP_0010545 abnormal heart layer morphology http://purl.obolibrary.org/obo/MP_0000266 abnormal heart morphology any structural anomaly of the laminar structure of the heart http://purl.obolibrary.org/obo/MP_0010551 abnormal coronary vessel morphology http://purl.obolibrary.org/obo/MP_0000266 abnormal heart morphology any structural anomaly of any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation http://purl.obolibrary.org/obo/MP_0010563 increased heart right ventricle size http://purl.obolibrary.org/obo/MP_0008772 increased heart ventricle size greater than average size of the right ventricle http://purl.obolibrary.org/obo/MP_0010564 abnormal fetal ductus arteriosus morphology http://purl.obolibrary.org/obo/MP_0000259 abnormal vascular development any structural anomaly of the fetal vessel that connects the left pulmonary artery with the descending aorta; the ductus arteriosus normally regresses into a fibrous cord, the ligamentum arteriousum after birth http://purl.obolibrary.org/obo/MP_0010577 abnormal heart right ventricle size http://purl.obolibrary.org/obo/MP_0003920 abnormal heart right ventricle morphology anomaly of the average size of the right ventricle compared to the average for a particular population http://purl.obolibrary.org/obo/MP_0010579 increased heart left ventricle size http://purl.obolibrary.org/obo/MP_0010578 abnormal heart left ventricle size greater than average size of the left ventricle http://purl.obolibrary.org/obo/MP_0010580 decreased heart left ventricle size http://purl.obolibrary.org/obo/MP_0010578 abnormal heart left ventricle size less than average size of the left ventricle compared to the average for a particular population http://purl.obolibrary.org/obo/MP_0010599 abnormal fetal atrioventricular canal septation http://purl.obolibrary.org/obo/MP_0006107 abnormal fetal atrioventricular canal morphology anomaly in the process by which the dorsal and ventral endocardial cushions develop in the walls of the common atrioventricular canal, grow toward each other and fuse, dividing the common atrioventricular canal into right and left atrioventricular canals and the atrioventricular septum http://purl.obolibrary.org/obo/MP_0010630 abnormal cardiac muscle tissue morphology http://purl.obolibrary.org/obo/MP_0002108 abnormal muscle morphology any structural anomaly of the involuntary muscle comprising the myocardium of the heart and the walls of the pulmonary veins and superior vena cava; cardiac muscle is striated and multinucleate, and the cardiomyocytes branch and are joined to one another via intercalated discs http://purl.obolibrary.org/obo/MP_0010639 altered tumor pathology http://purl.obolibrary.org/obo/MP_0002006 tumorigenesis any changes associated with the chemistry, immunohistology, cellular alterations or environmental interactions of tumors compared to the expected state http://purl.obolibrary.org/obo/MP_0010651 aorticopulmonary septal defect http://purl.obolibrary.org/obo/MP_0010650 abnormal aorticopulmonary septum morphology an abnormal communication in the septum between the aorta and pulmonary artery, resulting from incomplete separation of the common tube of the truncus arteriosus and the aorticopulmonary trunk http://purl.obolibrary.org/obo/MP_0010678 abnormal skin adnexa morphology http://purl.obolibrary.org/obo/MP_0010771 integument phenotype any structural anomaly of the tissue or structures associated with or embedded in the skin such as hair and hair follicles, sweat glands, sebaceous glands and claws or nails http://purl.obolibrary.org/obo/MP_0010680 abnormal skin adnexa physiology http://purl.obolibrary.org/obo/MP_0010771 integument phenotype any functional anomaly of the tissue or structures associated with or embedded in the skin such as hair and hair follicles, sweat glands, sebaceous glands and claws or nails http://purl.obolibrary.org/obo/MP_0010681 abnormal hair follicle bulb morphology http://purl.obolibrary.org/obo/MP_0000377 abnormal hair follicle morphology any structural anomaly of the thickened portion of the proximal portion of the hair follicle that contains rapidly proliferating matrix cells, melanocytes and outer root sheath cells http://purl.obolibrary.org/obo/MP_0010684 abnormal hair follicle outer root sheath morphology http://purl.obolibrary.org/obo/MP_0000377 abnormal hair follicle morphology any structural anomaly of the outermost layer of the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb http://purl.obolibrary.org/obo/MP_0010685 abnormal hair follicle inner root sheath morphology http://purl.obolibrary.org/obo/MP_0000377 abnormal hair follicle morphology any structural anomaly of the multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath; the layers of the inner root sheath include the companion layer, Henle's layer, Huxley's layer and the inner root sheath cuticle http://purl.obolibrary.org/obo/MP_0010686 abnormal hair follicle matrix region morphology http://purl.obolibrary.org/obo/MP_0010681 abnormal hair follicle bulb morphology any structural anomaly of the bulb region adjacent to the dermal papilla that contains rapidly proliferating matrix cells that give rise to the various cell lineages of the hair shaft and inner root sheath http://purl.obolibrary.org/obo/MP_0010726 abnormal collateral sprouting http://purl.obolibrary.org/obo/MP_0004811 abnormal neuron physiology aberrant response of a neuron to form new neuritic processes (sprouts) that emerge from the nerve fibers or terminal arborizations in response to nerve injury (such as section or denervation), application of neurotoxin, or target tissue atrophy (usually due to disease) http://purl.obolibrary.org/obo/MP_0010736 abnormal extraembryonic ectoderm morphology http://purl.obolibrary.org/obo/MP_0002086 abnormal extraembryonic tissue morphology any structural anomaly of the layer of the ectoderm of the extraembryonic tissue http://purl.obolibrary.org/obo/MP_0010754 abnormal heart left ventricle pressure http://purl.obolibrary.org/obo/MP_0008775 abnormal heart ventricle pressure any anomaly in the pressure within the left cardiac ventricle http://purl.obolibrary.org/obo/MP_0010760 abnormal macrophage chemotaxis http://purl.obolibrary.org/obo/MP_0011518 abnormal cell chemotaxis anomaly in the accumulation of macrophages in a specific location in response to a wide variety of substances released at the sites of inflammatory reactions http://purl.obolibrary.org/obo/MP_0010768 mortality/aging http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype characteristics involving the ability of an organism to live and age normally throughout development and life span http://purl.obolibrary.org/obo/MP_0010769 abnormal survival http://purl.obolibrary.org/obo/MP_0010768 mortality/aging deviation from the expected viability or life span of an organism http://purl.obolibrary.org/obo/MP_0010770 preweaning lethality http://purl.obolibrary.org/obo/MP_0010769 abnormal survival death anytime between fertilization and weaning age (Mus: approximately 3-4 weeks of age) http://purl.obolibrary.org/obo/MP_0010771 integument phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype the observable morphological and physiological characteristics of the skin and its associated structures, such as the hair, nails, sweat glands, sebaceous glands and other secretory glands http://purl.obolibrary.org/obo/MP_0010785 abnormal stomach pyloric region morphology http://purl.obolibrary.org/obo/MP_0000470 abnormal stomach morphology any structural anomaly of the stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum http://purl.obolibrary.org/obo/MP_0010792 abnormal stomach mucosa morphology http://purl.obolibrary.org/obo/MP_0010783 abnormal stomach wall morphology any structural anomaly of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae http://purl.obolibrary.org/obo/MP_0010832 lethality during fetal growth through weaning http://purl.obolibrary.org/obo/MP_0010770 preweaning lethality death anytime between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age) http://purl.obolibrary.org/obo/MP_0010853 abnormal lung position or orientation http://purl.obolibrary.org/obo/MP_0001175 abnormal lung morphology the lung is displaced from the normal position and/or has an altered left/right orientation http://purl.obolibrary.org/obo/MP_0010865 prenatal growth retardation http://purl.obolibrary.org/obo/MP_0004196 abnormal prenatal growth/weight/body size slow or limited development during the prenatal period http://purl.obolibrary.org/obo/MP_0010866 abnormal prenatal body size http://purl.obolibrary.org/obo/MP_0004196 abnormal prenatal growth/weight/body size anomaly in the average body weight, height and/or length of an organism compared to controls at anytime prior to birth http://purl.obolibrary.org/obo/MP_0010898 abnormal pulmonary alveolus epithelium morphology http://purl.obolibrary.org/obo/MP_0006382 abnormal lung epithelium morphology any structural anomaly of the epithelial layer of the alveoli http://purl.obolibrary.org/obo/MP_0010900 abnormal pulmonary interalveolar septum morphology http://purl.obolibrary.org/obo/MP_0010911 abnormal pulmonary acinus morphology any structural anomaly of the tissue intervening between two adjacent pulmonary alveoli, which consists of the basement membranes of alveolar-lining epithelium (mostly type I pneumocytes) and capillary endothelium; thicker alveolar septal regions may also contain elastic fibers, collagen, interstitial cells, smooth muscle cells, mast cells, lymphocytes and monocytes http://purl.obolibrary.org/obo/MP_0010901 abnormal pulmonary alveolar parenchyma morphology http://purl.obolibrary.org/obo/MP_0010899 abnormal pulmonary alveolar system morphology any structural anomaly of the distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages http://purl.obolibrary.org/obo/MP_0010911 abnormal pulmonary acinus morphology http://purl.obolibrary.org/obo/MP_0010899 abnormal pulmonary alveolar system morphology any structural anomaly of the part of the airway consisting of a respiratory bronchiole and all of its branches http://purl.obolibrary.org/obo/MP_0010942 abnormal respiratory epithelium morphology http://purl.obolibrary.org/obo/MP_0002132 abnormal respiratory system morphology any structural anomaly of the pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi http://purl.obolibrary.org/obo/MP_0011000 abnormal allogrooming behavior http://purl.obolibrary.org/obo/MP_0001440 abnormal grooming behavior defects in the standard of behavior in which individuals in a cohort clean or maintain one another's outer body or appearance http://purl.obolibrary.org/obo/MP_0011082 abnormal gastrointestinal motility http://purl.obolibrary.org/obo/MP_0001663 abnormal digestive system physiology anomaly in the propulsive movements of the digestive system, resulting in the transit of the contents along the gastrointestinal tract http://purl.obolibrary.org/obo/MP_0011180 abnormal hematopoietic cell number http://purl.obolibrary.org/obo/MP_0002123 abnormal hematopoiesis any anomaly in the expected number of cells of the hematopoietic lineage http://purl.obolibrary.org/obo/MP_0011181 increased hematopoietic cell number http://purl.obolibrary.org/obo/MP_0011180 abnormal hematopoietic cell number greater than expected number of cells of the hematopoietic lineage http://purl.obolibrary.org/obo/MP_0011182 decreased hematopoietic cell number http://purl.obolibrary.org/obo/MP_0011180 abnormal hematopoietic cell number fewer than expected number of cells of the hematopoietic lineage http://purl.obolibrary.org/obo/MP_0011187 abnormal parietal endoderm morphology http://purl.obolibrary.org/obo/MP_0011203 abnormal parietal yolk sac morphology any structural anomaly of the primitive endoderm-derived tissue that lines the luminal surface of the mural trophectoderm http://purl.obolibrary.org/obo/MP_0011204 abnormal visceral yolk sac blood island morphology http://purl.obolibrary.org/obo/MP_0001718 abnormal visceral yolk sac morphology any structural anomaly of the masses of developing blood cells attached to endothelium in the yolk sac http://purl.obolibrary.org/obo/MP_0011239 abnormal skin coloration http://purl.obolibrary.org/obo/MP_0002060 abnormal skin morphology a variation in an expected skin color or complexion that may be due to inflammation, pigment defects or other causes http://purl.obolibrary.org/obo/MP_0011260 abnormal head mesenchyme morphology http://purl.obolibrary.org/obo/MP_0012176 abnormal head development any structural anomaly of the primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells http://purl.obolibrary.org/obo/MP_0011333 abnormal kidney inner medulla morphology http://purl.obolibrary.org/obo/MP_0003014 abnormal kidney medulla morphology any structural anomaly of the inner medullary region of the adult kidney containing collecting ducts and the long loops of Henle http://purl.obolibrary.org/obo/MP_0011368 increased kidney apoptosis http://purl.obolibrary.org/obo/MP_0011367 abnormal kidney apoptosis increase in the number of cells of the kidney undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0011390 abnormal fetal cardiomyocyte physiology http://purl.obolibrary.org/obo/MP_0001544 abnormal cardiovascular system physiology any functional anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes http://purl.obolibrary.org/obo/MP_0011396 abnormal sleep behavior http://purl.obolibrary.org/obo/MP_0004924 abnormal behavior any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity http://purl.obolibrary.org/obo/MP_0011425 abnormal kidney interstitium morphology http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology any structural anomaly of the kidney region located between the nephrons, ureteric epithelia (ureteric tips, trunk and collecting duct system) and renal vasculature, and composed of renal support cells, including fibroblasts and macrophages, and mesenchymal stroma or interstitial cells; the renal vasculature lies within the renal interstitium but is not a part of it; various conditions can lead to scarring (fibrosis) and congestion of this area, which can cause kidney dysfunction and failure http://purl.obolibrary.org/obo/MP_0011468 abnormal urine amino acid level http://purl.obolibrary.org/obo/MP_0005332 abnormal amino acid level any anomaly in the amount in the urine of a carboxylic acid containing one or more amino groups (-NH2) and a carboxyl (-COOH) group http://purl.obolibrary.org/obo/MP_0011479 abnormal catecholamine level http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis any anomaly in the amount of catecholamines, including adrenaline, noradrenaline and L-dopamine; catecholamines are act as hormones or neurotransmitters and are derived from the amino acid tyrosine http://purl.obolibrary.org/obo/MP_0011484 abnormal ureter urothelium morphology http://purl.obolibrary.org/obo/MP_0003630 abnormal urothelium morphology any structural anomaly of the epithelial lining of the luminal space of the ureter http://purl.obolibrary.org/obo/MP_0011495 abnormal head shape http://purl.obolibrary.org/obo/MP_0000432 abnormal head morphology any anomaly in the characteristic surface outline or contour of a head of an organism http://purl.obolibrary.org/obo/MP_0011496 abnormal head size http://purl.obolibrary.org/obo/MP_0000432 abnormal head morphology anomaly in the average size of the portion of the body containing the brain and organs of sight, hearing, taste, and smell http://purl.obolibrary.org/obo/MP_0011504 abnormal limb long bone morphology http://purl.obolibrary.org/obo/MP_0003723 abnormal long bone morphology any structural anomaly of any of the several elongated bones of the extremities http://purl.obolibrary.org/obo/MP_0011521 decreased placental labyrinth size http://purl.obolibrary.org/obo/MP_0011519 abnormal placenta labyrinth size reduction in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood http://purl.obolibrary.org/obo/MP_0011655 abnormal systemic artery morphology http://purl.obolibrary.org/obo/MP_0002191 abnormal artery morphology any structural anomaly of the arteries that carry oxygenated blood away from the heart to the body, as opposed to the pulmonary arteries, which carry deoxygenated blood to the lungs http://purl.obolibrary.org/obo/MP_0011719 abnormal natural killer cell mediated cytotoxicity http://purl.obolibrary.org/obo/MP_0010766 abnormal NK cell physiology any anomaly in the process of directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors http://purl.obolibrary.org/obo/MP_0011723 ectopic neuron http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology appearance of a neuron or group of neurons in a region where it is not normally found http://purl.obolibrary.org/obo/MP_0011750 abnormal seminiferous tubule epithelium morphology http://purl.obolibrary.org/obo/MP_0002216 abnormal seminiferous tubule morphology any structural anomaly of the stratified epithelial lining of the seminiferous tubules, consisting of the developing spermatozoa and the supporting Sertoli cells, which are tall, columnar type cells that line the tubule http://purl.obolibrary.org/obo/MP_0011762 renal/urinary system inflammation http://purl.obolibrary.org/obo/MP_0005502 abnormal renal/urinary system physiology local accumulation of fluid, plasma proteins, and leukocytes in the renal/urinary system; may involve inflammation of the urethra, urinary bladder, ureters or kidneys http://purl.obolibrary.org/obo/MP_0011796 abnormal external urethral orifice morphology http://purl.obolibrary.org/obo/MP_0000537 abnormal urethra morphology any structural anomaly of the external opening or orifice of the urethra through which urine and seminal fluid (in males only) leave the body; in males the meatus presents as a vertical slit normally positioned at the tip of glans penis; in females the meatus is located between the clitoris and the vagina in the vulvular vestibule of the female genitalia http://purl.obolibrary.org/obo/MP_0011898 abnormal platelet cell number http://purl.obolibrary.org/obo/MP_0011180 abnormal hematopoietic cell number anomaly in the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation http://purl.obolibrary.org/obo/MP_0011913 abnormal reticulocyte cell number http://purl.obolibrary.org/obo/MP_0002424 abnormal reticulocyte morphology altered number of immature (nucleated) erythrocytes http://purl.obolibrary.org/obo/MP_0011939 increased food intake http://purl.obolibrary.org/obo/MP_0005449 abnormal food intake increase in the total number of calories/food amount taken in over time when compared to the normal state http://purl.obolibrary.org/obo/MP_0011941 increased fluid intake http://purl.obolibrary.org/obo/MP_0011947 abnormal fluid intake increase in the total amount of fluid taken in over time when compared to the normal state http://purl.obolibrary.org/obo/MP_0011942 decreased fluid intake http://purl.obolibrary.org/obo/MP_0011947 abnormal fluid intake reduction in the total amount of fluid taken in over time when compared to the normal state http://purl.obolibrary.org/obo/MP_0011969 abnormal circulating triglyceride level http://purl.obolibrary.org/obo/MP_0003949 abnormal circulating lipid level abnormal concentration of naturally occurring esters of three fatty acids and glycerol in the blood; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver http://purl.obolibrary.org/obo/MP_0011973 abnormal circulating glycerol level http://purl.obolibrary.org/obo/MP_0003949 abnormal circulating lipid level abnormal blood level of trihydroxy sugar alcohols that are precursors for synthesis of triacylglycerols, and of phospholipids and cellular glucose in the liver and adipose tissue; fat catabolism results in the release of glycerol and fatty acids into the bloodstream to be used as an energy source http://purl.obolibrary.org/obo/MP_0011976 sweet preference http://purl.obolibrary.org/obo/MP_0001432 abnormal food preference subjects demonstrate predilection for sweet tasting substances over other offered substance http://purl.obolibrary.org/obo/MP_0011977 abnormal sodium ion homeostasis http://purl.obolibrary.org/obo/MP_0001765 abnormal ion homeostasis anomaly in the processes involved in the maintenance of an internal equilibrium of sodium ions within the body or between a cell and its external environment http://purl.obolibrary.org/obo/MP_0011978 abnormal potassium ion homeostasis http://purl.obolibrary.org/obo/MP_0001765 abnormal ion homeostasis anomaly in the processes involved in the maintenance of an internal equilibrium of potassium ions within the body or between a cell and its external environment http://purl.obolibrary.org/obo/MP_0011979 abnormal magnesium ion homeostasis http://purl.obolibrary.org/obo/MP_0001765 abnormal ion homeostasis anomaly in the processes involved in the maintenance of an internal equilibrium of magnesium ions within the body or between a cell and its external environment http://purl.obolibrary.org/obo/MP_0011989 abnormal porphyrin level http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis aberrant concentration of porphyrins or protoporphyrins http://purl.obolibrary.org/obo/MP_0011999 abnormal tail length http://purl.obolibrary.org/obo/MP_0002111 abnormal tail morphology any anomaly in the length of tail relative to average of a given reference population http://purl.obolibrary.org/obo/MP_0012007 abnormal chloride level http://purl.obolibrary.org/obo/MP_0001765 abnormal ion homeostasis any change in the amount of chloride, the major extracellular anion in mammals; it plays roles in tissue fluid homeostasis and also helps maintain proper blood volume, blood pressure, and body fluid pH http://purl.obolibrary.org/obo/MP_0012018 abnormal oviduct physiology http://purl.obolibrary.org/obo/MP_0003699 abnormal female reproductive system physiology any functional anomaly of the tube through which the ova pass from the ovary to the uterus http://purl.obolibrary.org/obo/MP_0012065 increased astrocyte number http://purl.obolibrary.org/obo/MP_0012064 abnormal astrocyte number increase in the number of the large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord http://purl.obolibrary.org/obo/MP_0012076 abnormal agouti pigmentation http://purl.obolibrary.org/obo/MP_0002075 abnormal coat/hair pigmentation amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is variably increased or decreased compared with a wild-type agouti pattern resulting in a range of coat color from yellow to almost black http://purl.obolibrary.org/obo/MP_0012091 increased midbrain size http://purl.obolibrary.org/obo/MP_0012088 abnormal midbrain size greater than average size of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes http://purl.obolibrary.org/obo/MP_0012103 abnormal bilaminar embryonic disc http://purl.obolibrary.org/obo/MP_0009781 abnormal preimplantation embryo development any structural anomaly of the flattened, almost circular bilaminar plate of cells formed when the inner cell mass (aka embryoblast) forms two epithelial layers, each of a distinct lineage, separated by an extracellular basement membrane: the external (dorsal) layer is called the epiblast and the internal (ventral) layer is called the hypoblast (aka primitive endoderm); together, they compose the bilaminar embryonic disc http://purl.obolibrary.org/obo/MP_0012106 impaired exercise endurance http://purl.obolibrary.org/obo/MP_0002899 fatigue impaired performance during controlled physical activity http://purl.obolibrary.org/obo/MP_0012107 enhanced exercise endurance http://purl.obolibrary.org/obo/MP_0002332 abnormal exercise endurance improved performance during controlled physical activity http://purl.obolibrary.org/obo/MP_0012132 abnormal midbrain-hindbrain boundary morphology http://purl.obolibrary.org/obo/MP_0000913 abnormal brain development any structural anomaly of the midbrain-hindbrain domain of the embryonic brain that is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; normally, an organizing center located at the boundary patterns the midbrain and hindbrain primordia of the neural plate http://purl.obolibrary.org/obo/MP_0012138 decreased forebrain size http://purl.obolibrary.org/obo/MP_0012137 abnormal forebrain size size reduction or truncation of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions) http://purl.obolibrary.org/obo/MP_0012167 abnormal epigenetic regulation of gene expression http://purl.obolibrary.org/obo/MP_0005621 abnormal cell physiology any anomaly in the process that modulates the frequency, rate or extent of gene expression, in which the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence http://purl.obolibrary.org/obo/MP_0012186 abnormal muscle precursor cell physiology http://purl.obolibrary.org/obo/MP_0002106 abnormal muscle physiology anomaly in the function of cells that will develop into muscle cells http://purl.obolibrary.org/obo/MP_0012224 abnormal sterol level http://purl.obolibrary.org/obo/MP_0001547 abnormal lipid level anomaly in the level of any of a group of predominantly unsaturated solid alcohols of the steroid group, usually with a hydroxyl group (OH) attached to the third carbon atom, and are present in the fatty tissues of plants and animals; sterols may be found either as free sterols, acylated, alkylated, sulfated, or linked to a glycoside moiety which can be itself acylated http://purl.obolibrary.org/obo/MP_0012225 decreased sterol level http://purl.obolibrary.org/obo/MP_0012224 abnormal sterol level reduction in the level of any of a group of predominantly unsaturated solid alcohols of the steroid group, usually with a hydroxyl group (OH) attached to the third carbon atom, and are present in the fatty tissues of plants and animals; sterols may be found either as free sterols, acylated, alkylated, sulfated, or linked to a glycoside moiety which can be itself acylated http://purl.obolibrary.org/obo/MP_0012226 increased sterol level http://purl.obolibrary.org/obo/MP_0012224 abnormal sterol level greater level of any of a group of predominantly unsaturated solid alcohols of the steroid group, usually with a hydroxyl group (OH) attached to the third carbon atom, and are present in the fatty tissues of plants and animals; sterols may be found either as free sterols, acylated, alkylated, sulfated, or linked to a glycoside moiety which can be itself acylated http://purl.obolibrary.org/obo/MP_0012288 abnormal paradoxical sleep pattern http://purl.obolibrary.org/obo/MP_0001501 abnormal sleep pattern any anomaly in the frequency or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity http://purl.obolibrary.org/obo/MP_0012296 impaired discrimination learning http://purl.obolibrary.org/obo/MP_0012315 impaired learning impaired ability to exhibit a differential response to different stimuli that is achieved by the reinforcement of the desired response for each particular stimulus http://purl.obolibrary.org/obo/MP_0012300 abnormal umbilical cord blood vessel morphology http://purl.obolibrary.org/obo/MP_0001725 abnormal umbilical cord morphology any structural anomaly of the three blood vessels, usually one large umbilical vein and two small umbilical arteries, buried within Wharton's jelly, that transport blood to and from the placenta, where exchange between the mother and fetus takes place; the umbilical vein carries oxygenated, nutrient-rich blood from the placenta to the fetus, and the umbilical arteries carry deoxygenated, nutrient-depleted blood from the fetus to the placenta http://purl.obolibrary.org/obo/MP_0012312 impaired avoidance learning behavior http://purl.obolibrary.org/obo/MP_0012315 impaired learning impaired ability to associate a previously neutral stimulus with an unpleasant or punishing stimuli so that the animal learns to avoid the previously neutral stimulus http://purl.obolibrary.org/obo/MP_0012313 enhanced avoidance learning behavior http://purl.obolibrary.org/obo/MP_0012314 enhanced learning enhanced ability to associate a previously neutral stimulus with an unpleasant or punishing stimuli so that the animal learns to avoid the previously neutral stimulus http://purl.obolibrary.org/obo/MP_0012322 decreased total tissue mass http://purl.obolibrary.org/obo/MP_0012321 abnormal total tissue mass decreased physical bulk or volume of the body including lean body mass, fat body mass, and bone tissue http://purl.obolibrary.org/obo/MP_0012323 increased total tissue mass http://purl.obolibrary.org/obo/MP_0012321 abnormal total tissue mass increased physical bulk or volume of the body including lean body mass, fat body mass, and bone tissue http://purl.obolibrary.org/obo/MP_0012348 decreased susceptibility to induction of seizure by inducing agent http://purl.obolibrary.org/obo/MP_0009357 abnormal seizure response to inducing agent higher threshold to induction of seizure activity response by an agent that normally can induce uncontrolled electrical activity in the brain, producing a physical convulsion and/or minor change in physical behavior http://purl.obolibrary.org/obo/MP_0012349 increased susceptibility to induction of seizure by inducing agent http://purl.obolibrary.org/obo/MP_0009357 abnormal seizure response to inducing agent lower threshold to induction of seizure activity response by an agent that normally can induce uncontrolled electrical activity in the brain, producing a physical convulsion and/or minor change in physical behavior http://purl.obolibrary.org/obo/MP_0012382 abnormal blood cell physiology http://purl.obolibrary.org/obo/MP_0001545 abnormal hematopoietic system physiology aberrant measurable or observable characteristic related to the function of or processes in any of the cells found in the blood http://purl.obolibrary.org/obo/MP_0012401 long nails http://purl.obolibrary.org/obo/MP_0000579 abnormal nail morphology increased length of the nails http://purl.obolibrary.org/obo/MP_0012431 increased lymphoma incidence http://purl.obolibrary.org/obo/MP_0010296 increased hemolymphoid system tumor incidence greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0012436 increased colon tumor incidence http://purl.obolibrary.org/obo/MP_0010279 increased gastrointestinal tumor incidence greater than the expected number of neoplasms in the colon, usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0012440 abnormal neutrophil cell number http://purl.obolibrary.org/obo/MP_0020201 abnormal granulocyte number deviation in the count of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes http://purl.obolibrary.org/obo/MP_0012441 abnormal monocyte cell number http://purl.obolibrary.org/obo/MP_0002620 abnormal monocyte morphology any deviation in the count of the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood http://purl.obolibrary.org/obo/MP_0012442 abnormal basophil cell number http://purl.obolibrary.org/obo/MP_0020201 abnormal granulocyte number deviation of the count of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size http://purl.obolibrary.org/obo/MP_0012501 abnormal pericardial cavity morphology http://purl.obolibrary.org/obo/MP_0000266 abnormal heart morphology any structural anomaly of the anatomical body cavity in which the heart lies; the pericardial cavity forms in the lateral plate mesoderm above the buccopharyngeal membrane, as part of the early intraembryonic coelom, and is initially continuous with the two early pleural cavities http://purl.obolibrary.org/obo/MP_0012523 abnormal upper lip morphology http://purl.obolibrary.org/obo/MP_0003769 abnormal lip morphology any structural anomaly of the muscular fold forming the superior border of the mouth http://purl.obolibrary.org/obo/MP_0012543 abnormal rostral neuropore morphology http://purl.obolibrary.org/obo/MP_0012542 abnormal neuropore morphology any structural anomaly of the temporary opening at the extreme rostral (cephalic) end of the early embryonic prosencephalon (forebrain); the anterior neuropore appears before the process of neural tube closure is complete http://purl.obolibrary.org/obo/MP_0012676 dilated brain ventricles http://purl.obolibrary.org/obo/MP_0000822 abnormal brain ventricle morphology the luminal space of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord is increased in volume or area, usually with an increase in contained fluid http://purl.obolibrary.org/obo/MP_0012745 abnormal neural crest cell physiology http://purl.obolibrary.org/obo/MP_0008932 abnormal embryonic tissue physiology any functional anomaly in the complex process by which multipotent neural crest progenitors acquire migratory and invasive properties, emigrate from the dorsal aspect of the neural tube, migrate along distinct pathways, and differentiate into diverse cell types http://purl.obolibrary.org/obo/MP_0012762 abnormal alpha-beta T cell morphology http://purl.obolibrary.org/obo/MP_0008037 abnormal T cell morphology any structural anomaly of a T cell that expresses an alpha-beta T cell receptor complex http://purl.obolibrary.org/obo/MP_0012775 abnormal brain weight http://purl.obolibrary.org/obo/MP_0000771 abnormal brain size anomaly in the average weight of the brain http://purl.obolibrary.org/obo/MP_0013151 abnormal incidence of induced tumors http://purl.obolibrary.org/obo/MP_0002019 abnormal tumor incidence aberration from the normal frequency of tumor incidence induced by a carcinogen, mutagen or virus http://purl.obolibrary.org/obo/MP_0013189 abnormal exploration in a new environment http://purl.obolibrary.org/obo/MP_0001413 abnormal response to new environment anomaly in the amount of time spent investigating new location http://purl.obolibrary.org/obo/MP_0013203 abnormal primary cilium morphology http://purl.obolibrary.org/obo/MP_0013202 abnormal cilium morphology any structural anomaly of a cilium found on many different cell types that is typically present in a single copy per cell; a primary cilium may have a variable array of axonemal microtubules and may or may not contain molecular motors http://purl.obolibrary.org/obo/MP_0013245 abnormal lipid metabolism http://purl.obolibrary.org/obo/MP_0005266 abnormal metabolism any anomaly in the chemical reactions and pathways involving a lipid, including metabolic, catabolic and biosynthetic processes http://purl.obolibrary.org/obo/MP_0013246 abnormal peptide metabolism http://purl.obolibrary.org/obo/MP_0005266 abnormal metabolism any anomaly in the chemical reactions and pathways involving a peptide, including metabolic, catabolic and biosynthetic processes http://purl.obolibrary.org/obo/MP_0013254 abnormal angiotensin I-converting enzyme activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity reduced activity of the exopeptidase that catalyses the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, and is also involved in the inactivation of bradykinin http://purl.obolibrary.org/obo/MP_0013258 abnormal extracellular matrix morphology http://purl.obolibrary.org/obo/MP_0005384 cellular phenotype any structural anomaly of the structure lying external to one or more cells, which provides structural support for cells or tissues; in mammals, the extracellular matrix is completely external to the cell http://purl.obolibrary.org/obo/MP_0013284 abnormal renal glomerular filtration http://purl.obolibrary.org/obo/MP_0013285 abnormal renal filtration anomaly in the process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells http://purl.obolibrary.org/obo/MP_0013286 abnormal sperm capacitation http://purl.obolibrary.org/obo/MP_0004543 abnormal sperm physiology anomaly in the change undergone by spermatozoa in the female genital tract that enables them to penetrate and fertilize an egg http://purl.obolibrary.org/obo/MP_0013306 abnormal tela choroidea morphology http://purl.obolibrary.org/obo/MP_0000822 abnormal brain ventricle morphology any structural anomaly of that portion of the brain pia mater that covers the ependymal roof or, in the case of the lateral ventricle, medial wall of a cerebral ventricle; vascularized tela choroidea is choroid plexus http://purl.obolibrary.org/obo/MP_0013324 abnormal female reproductive gland morphology http://purl.obolibrary.org/obo/MP_0000653 abnormal sex gland morphology any structural anomaly of any sex gland that is part of the female reproductive system http://purl.obolibrary.org/obo/MP_0013325 abnormal male reproductive gland morphology http://purl.obolibrary.org/obo/MP_0000653 abnormal sex gland morphology any structural anomaly of any sex gland that is part of the male reproductive system http://purl.obolibrary.org/obo/MP_0013326 abnormal female reproductive gland physiology http://purl.obolibrary.org/obo/MP_0005647 abnormal sex gland physiology any functional anomaly of any sex gland that is part of the female reproductive system http://purl.obolibrary.org/obo/MP_0013327 abnormal male reproductive gland physiology http://purl.obolibrary.org/obo/MP_0005647 abnormal sex gland physiology any functional anomaly of any sex gland that is part of the male reproductive system http://purl.obolibrary.org/obo/MP_0013329 abnormal preputial gland morphology http://purl.obolibrary.org/obo/MP_0000653 abnormal sex gland morphology any structural anomaly of the paired, lobulated, modified sebaceous glands located in the inguinal region adjacent to the penis and vagina, with pheromonal functions in male rodents; in males, the preputial gland empties into the preputial cavity and in females, the preputial (aka clitoral) gland duct empties into the clitoral fossa http://purl.obolibrary.org/obo/MP_0013330 abnormal male accessory sex gland morphology http://purl.obolibrary.org/obo/MP_0013325 abnormal male reproductive gland morphology any structural anomaly of any gland, other than the gonad, associated with the genital tract, such as the ampulla of the ductus deferens and the bulbourethral, prostate and seminal vesicles of the male http://purl.obolibrary.org/obo/MP_0013337 abnormal adenohypophysis development http://purl.obolibrary.org/obo/MP_0004163 abnormal adenohypophysis morphology aberrant formation or incomplete differentiation of the anterior lobe of the pituitary gland which arises as a pouch-like outgrowth of ectoderm known as the hypophyseal (Rathke's) pouch from the dorsal midline roof of the stomodeum (primitive oral cavity); the hypophyseal pouch grows toward the brain and the neurohypophyseal bud; as the hypophyseal pouch and the infundibulum make contact, the hypophyseal pouch loses its connection with the pharynx, creating a hollow ball of cells that lies inferior to the floor of the diencephalon posterior to the optic chiasm; these cells undergo division, the central chamber gradually disappears, and this endocrine mass becomes the anterior pituitary gland; the fully developed adenohypophysis consists of a glandular pars distalis, a thin proximal extension called the pars tuberalis, and a narrow pars intermedia http://purl.obolibrary.org/obo/MP_0013450 abnormal lacrimal apparatus physiology http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology any functional anomaly of the network of orbital structures of the eye that secrete and drain tears from the surface of the eyeball into the nasal cavity; these parts include the lacrimal glands, lacrimal lake, lacrimal ducts, lacrimal canals, lacrimal sacs, nasolacrimal ducts, and lacrimal puncta http://purl.obolibrary.org/obo/MP_0020135 abnormal heart ventricle wall thickness http://purl.obolibrary.org/obo/MP_0005294 abnormal heart ventricle morphology anomaly in the depth of the cardiac wall of the heart ventricles http://purl.obolibrary.org/obo/MP_0020147 abnormal defecation amount http://purl.obolibrary.org/obo/MP_0003866 abnormal defecation anomaly in the amount of discharge of feces from the body compared to the control http://purl.obolibrary.org/obo/MP_0020149 abnormal mortality induced by ionizing radiation http://purl.obolibrary.org/obo/MP_0012734 abnormal response to radiation anomaly in the sensitivity to doses of ionizing radiation that include ultraviolet light, X-rays, or gamma rays, resulting in death http://purl.obolibrary.org/obo/MP_0020150 abnormal timing of vaginal opening http://purl.obolibrary.org/obo/MP_0001937 abnormal sexual maturation anomaly in the age of the opening of the genital canal in a female compared to the control http://purl.obolibrary.org/obo/MP_0020151 abnormal circulating non-HDL cholesterol level http://purl.obolibrary.org/obo/MP_0000180 abnormal circulating cholesterol level any anomaly in the amount in the blood of non-HDL cholesterol http://purl.obolibrary.org/obo/MP_0020167 abnormal vertical activity http://purl.obolibrary.org/obo/MP_0003313 abnormal locomotor activation altered ability or desire to jump or rear http://purl.obolibrary.org/obo/MP_0020171 abnormal IgA level http://purl.obolibrary.org/obo/MP_0002490 abnormal immunoglobulin level deviation from the normal levels of immunoglobulin class A level http://purl.obolibrary.org/obo/MP_0020172 abnormal IgD level http://purl.obolibrary.org/obo/MP_0002490 abnormal immunoglobulin level deviation from the normal levels of immunoglobulin class D level http://purl.obolibrary.org/obo/MP_0020173 abnormal IgE level http://purl.obolibrary.org/obo/MP_0002490 abnormal immunoglobulin level deviation from the normal levels of immunoglobulin class E level http://purl.obolibrary.org/obo/MP_0020174 abnormal IgG level http://purl.obolibrary.org/obo/MP_0002490 abnormal immunoglobulin level deviation from the normal levels of immunoglobulin class G level http://purl.obolibrary.org/obo/MP_0020180 abnormal IgM level http://purl.obolibrary.org/obo/MP_0002490 abnormal immunoglobulin level deviation from the normal levels of immunoglobulin class M level http://purl.obolibrary.org/obo/MP_0020185 altered susceptibility to viral infection http://purl.obolibrary.org/obo/MP_0001793 altered susceptibility to infection a change in the likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus http://purl.obolibrary.org/obo/MP_0020186 altered susceptibility to bacterial infection http://purl.obolibrary.org/obo/MP_0001793 altered susceptibility to infection a change in the likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria http://purl.obolibrary.org/obo/MP_0020190 abnormal lung adenoma incidence http://purl.obolibrary.org/obo/MP_0020189 abnormal adenoma incidence an anomaly in the expected number of a benign epithelial neoplasm with a glandular organization arising in the lung, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0020201 abnormal granulocyte number http://purl.obolibrary.org/obo/MP_0011180 abnormal hematopoietic cell number an anomaly in the number of leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils http://purl.obolibrary.org/obo/MP_0020202 abnormal macrophage cell number http://purl.obolibrary.org/obo/MP_0011180 abnormal hematopoietic cell number an anomaly in the number of macrophages http://purl.obolibrary.org/obo/MP_0020203 abnormal mast cell number http://purl.obolibrary.org/obo/MP_0020201 abnormal granulocyte number an anomaly in the number of the cells that are found in almost all tissues, containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation http://purl.obolibrary.org/obo/MP_0020204 abnormal heart left ventricle weight http://purl.obolibrary.org/obo/MP_0010578 abnormal heart left ventricle size anomaly in the average weight of the left ventricle compared to the control http://purl.obolibrary.org/obo/MP_0020205 abnormal heart right ventricle weight http://purl.obolibrary.org/obo/MP_0010577 abnormal heart right ventricle size anomaly in the average weight of the right ventricle compared to the control http://purl.obolibrary.org/obo/MP_0020218 abnormal tear production http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology an anomaly in the amount of fluid produced in the eye http://purl.obolibrary.org/obo/MP_0004347 abnormal scapular spine morphology http://purl.obolibrary.org/obo/MP_0000149 abnormal scapula morphology any structural anomaly of the triangular ridge on the dorsal aspect of the scapula which separates the supra- from the infraspinatous fossa and where the trapezius and deltoid muscles are attached http://purl.obolibrary.org/obo/MP_0004348 long femur http://purl.obolibrary.org/obo/MP_0004695 increased length of long bones increased length of the long bone of the thigh http://purl.obolibrary.org/obo/MP_0004349 absent femur http://purl.obolibrary.org/obo/MP_0000559 abnormal femur morphology missing the long bone of the thigh http://purl.obolibrary.org/obo/MP_0004350 long humerus http://purl.obolibrary.org/obo/MP_0005296 abnormal humerus morphology increased length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below http://purl.obolibrary.org/obo/MP_0004351 short humerus http://purl.obolibrary.org/obo/MP_0005296 abnormal humerus morphology reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below http://purl.obolibrary.org/obo/MP_0004352 absent humerus http://purl.obolibrary.org/obo/MP_0005296 abnormal humerus morphology missing one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below http://purl.obolibrary.org/obo/MP_0004353 abnormal deltoid tuberosity morphology http://purl.obolibrary.org/obo/MP_0005296 abnormal humerus morphology any structural anomaly of a rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches http://purl.obolibrary.org/obo/MP_0004354 absent deltoid tuberosity http://purl.obolibrary.org/obo/MP_0004353 abnormal deltoid tuberosity morphology missing the rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches http://purl.obolibrary.org/obo/MP_0004355 short radius http://purl.obolibrary.org/obo/MP_0004686 decreased length of long bones reduced length of the short bone of the lateral forearm http://purl.obolibrary.org/obo/MP_0004356 radius hypoplasia http://purl.obolibrary.org/obo/MP_0000552 abnormal radius morphology underdevelopment or reduced size, usually due to a reduced number of cells, in the short bone of the lateral forearm http://purl.obolibrary.org/obo/MP_0004357 long tibia http://purl.obolibrary.org/obo/MP_0004695 increased length of long bones increased length of the medial and larger of the two bones of the lower leg http://purl.obolibrary.org/obo/MP_0004358 bowed tibia http://purl.obolibrary.org/obo/MP_0000558 abnormal tibia morphology increased curvature of the medial and larger of the two bones of the lower leg http://purl.obolibrary.org/obo/MP_0004359 short ulna http://purl.obolibrary.org/obo/MP_0005108 abnormal ulna morphology reduced length of the medial and larger of the two bones of the forearm http://purl.obolibrary.org/obo/MP_0004360 absent ulna http://purl.obolibrary.org/obo/MP_0005108 abnormal ulna morphology missing the medial and larger of the two bones of the forearm http://purl.obolibrary.org/obo/MP_0004361 bowed ulna http://purl.obolibrary.org/obo/MP_0005108 abnormal ulna morphology increased curvature of the medial and larger of the two bones of the forearm http://purl.obolibrary.org/obo/MP_0004362 cochlear hair cell degeneration http://purl.obolibrary.org/obo/MP_0003224 neuron degeneration degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve http://purl.obolibrary.org/obo/MP_0004363 stria vascularis degeneration http://purl.obolibrary.org/obo/MP_0000048 abnormal stria vascularis morphology degeneration or loss of the stratified, secretory epithelium which lines the upper part of the cochlear spiral ligament and maintains potassium ion homeostasis in the endolymph http://purl.obolibrary.org/obo/MP_0004364 thin stria vascularis http://purl.obolibrary.org/obo/MP_0000048 abnormal stria vascularis morphology reduced thickness of the stratified, secretory epithelium which lines the upper part of the cochlear spiral ligament and maintains potassium ion homeostasis in the endolymph http://purl.obolibrary.org/obo/MP_0004365 abnormal strial basal cell morphology http://purl.obolibrary.org/obo/MP_0000048 abnormal stria vascularis morphology any structural anomaly in the polarized cells which are juxtaposed to fibrocytes in the underlying spiral ligament http://purl.obolibrary.org/obo/MP_0004366 abnormal strial marginal cell morphology http://purl.obolibrary.org/obo/MP_0000048 abnormal stria vascularis morphology any structural anomaly in the polarized columnar cells of epithelial origin which cover the lateral surface of the cochlear duct, secrete potassium ions and form a continuous sheet in contact with the endolymph; marginal cells form extensive interdigitations with the basal and intermediate cells in the normal adult stria http://purl.obolibrary.org/obo/MP_0004367 abnormal strial intermediate cell morphology http://purl.obolibrary.org/obo/MP_0009390 abnormal otic pigmentation any structural anomaly in the melanocytes known to migrate from the neural crest during ontogeny to become located between the epithelial marginal cell layer and the mesodermal basal cell layer within the intrastrial space; the predominant cellular component of the electrogenic machinery that generates an endocochlear potential (80-100 mV) http://purl.obolibrary.org/obo/MP_0004368 abnormal stria vascularis vasculature morphology http://purl.obolibrary.org/obo/MP_0001614 abnormal blood vessel morphology any structural anomaly of the blood vessels supplying the stria vascularis in the cochlea of the inner ear http://purl.obolibrary.org/obo/MP_0004369 absent utricle http://purl.obolibrary.org/obo/MP_0006090 abnormal utricle morphology absence of the larger of the two sacs in the vestibule http://purl.obolibrary.org/obo/MP_0004370 long ulna http://purl.obolibrary.org/obo/MP_0005108 abnormal ulna morphology increased length of the medial and larger of the two bones of the forearm http://purl.obolibrary.org/obo/MP_0004371 bowed femur http://purl.obolibrary.org/obo/MP_0000559 abnormal femur morphology increased curvature of the long bone of the thigh http://purl.obolibrary.org/obo/MP_0004372 bowed fibula http://purl.obolibrary.org/obo/MP_0002187 abnormal fibula morphology increased curvature of the lateral and smaller bone of the lower limb http://purl.obolibrary.org/obo/MP_0004373 bowed humerus http://purl.obolibrary.org/obo/MP_0005296 abnormal humerus morphology increased curvature of the bone of the forelimb that articulates with the scapula above and the radius and ulna below http://purl.obolibrary.org/obo/MP_0004374 bowed radius http://purl.obolibrary.org/obo/MP_0000552 abnormal radius morphology increased curvature of the short bone of the lateral forearm http://purl.obolibrary.org/obo/MP_0004375 enlarged frontal bone http://purl.obolibrary.org/obo/MP_0000107 abnormal frontal bone morphology increased size of the bone forming the forehead and roof of the eye orbit http://purl.obolibrary.org/obo/MP_0004376 absent frontal bone http://purl.obolibrary.org/obo/MP_0000107 abnormal frontal bone morphology absence of the bone forming the forehead and roof of the eye orbit http://purl.obolibrary.org/obo/MP_0004377 small frontal bone http://purl.obolibrary.org/obo/MP_0000107 abnormal frontal bone morphology reduced size of the bone forming the forehead and roof of the eye orbit http://purl.obolibrary.org/obo/MP_0004378 frontal bone foramen http://purl.obolibrary.org/obo/MP_0000107 abnormal frontal bone morphology presence of a hole in the bone forming the forehead and roof of the eye orbit http://purl.obolibrary.org/obo/MP_0004379 wide frontal bone http://purl.obolibrary.org/obo/MP_0000107 abnormal frontal bone morphology increased width of the bone forming the forehead and roof of the eye orbit http://purl.obolibrary.org/obo/MP_0004380 short frontal bone http://purl.obolibrary.org/obo/MP_0000107 abnormal frontal bone morphology reduced length of the bone forming the forehead and roof of the eye orbit http://purl.obolibrary.org/obo/MP_0004381 abnormal hair follicle melanocyte morphology http://purl.obolibrary.org/obo/MP_0002877 abnormal melanocyte morphology any structural anomaly of the cells that produce pigment in the hair follicles http://purl.obolibrary.org/obo/MP_0004382 abnormal hair follicle melanogenesis http://purl.obolibrary.org/obo/MP_0005077 abnormal melanogenesis failure of or anomaly in the biosynthetic pathway of melanin formation in hair follicles http://purl.obolibrary.org/obo/MP_0004383 absent interparietal bone http://purl.obolibrary.org/obo/MP_0000077 abnormal interparietal bone morphology absence of the bone of the cranium that lies above and anterior to the occipital bone in some mammals http://purl.obolibrary.org/obo/MP_0004384 small interparietal bone http://purl.obolibrary.org/obo/MP_0000077 abnormal interparietal bone morphology reduced size of the bone of the cranium that lies above and anterior to the occipital bone in some mammals http://purl.obolibrary.org/obo/MP_0004385 interparietal bone hypoplasia http://purl.obolibrary.org/obo/MP_0004384 small interparietal bone underdevelopment or reduced size, usually due to a reduced number of cells, in the bone of the cranium that lies above and anterior to the occipital bone in some mammals http://purl.obolibrary.org/obo/MP_0004386 enlarged interparietal bone http://purl.obolibrary.org/obo/MP_0000077 abnormal interparietal bone morphology increased size of the bone of the cranium that lies above and anterior to the occipital bone in some mammals http://purl.obolibrary.org/obo/MP_0004387 abnormal prechordal plate morphology http://purl.obolibrary.org/obo/MP_0002084 abnormal developmental patterning any structural anomaly of the horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue http://purl.obolibrary.org/obo/MP_0004388 absent prechordal plate http://purl.obolibrary.org/obo/MP_0004387 abnormal prechordal plate morphology absence of the horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue http://purl.obolibrary.org/obo/MP_0004389 abnormal respiratory bronchiole morphology http://purl.obolibrary.org/obo/MP_0010911 abnormal pulmonary acinus morphology any structural anomaly of the smallest bronchioles, which connect the terminal bronchioles to alveolar ducts and have alveoli rising from their walls http://purl.obolibrary.org/obo/MP_0004390 abnormal bronchoalveolar duct junction morphology http://purl.obolibrary.org/obo/MP_0004389 abnormal respiratory bronchiole morphology any structural anomaly of the branch point connecting the respiratory bronchioles to the alveolar ducts http://purl.obolibrary.org/obo/MP_0004392 abnormal CD8-positive, alpha-beta T cell physiology http://purl.obolibrary.org/obo/MP_0002444 abnormal T cell physiology any functional anomaly of the subset of T lymphocytes that express the CD8 marker on the cell surface http://purl.obolibrary.org/obo/MP_0004393 abnormal cochlear inner hair cell morphology http://purl.obolibrary.org/obo/MP_0002622 abnormal cochlear hair cell morphology any structural anomaly in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell's surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane http://purl.obolibrary.org/obo/MP_0004394 abnormal cochlear inner hair cell number http://purl.obolibrary.org/obo/MP_0004393 abnormal cochlear inner hair cell morphology abnormal number of the flask-shaped inner hair sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve http://purl.obolibrary.org/obo/MP_0004395 increased cochlear inner hair cell number http://purl.obolibrary.org/obo/MP_0004407 increased cochlear hair cell number increased number (or more than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti http://purl.obolibrary.org/obo/MP_0004396 decreased cochlear inner hair cell number http://purl.obolibrary.org/obo/MP_0004408 decreased cochlear hair cell number decreased number (or less than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti http://purl.obolibrary.org/obo/MP_0004397 absent cochlear inner hair cells http://purl.obolibrary.org/obo/MP_0004405 absent cochlear hair cells absence of the single row of flask-shaped inner hair sensory cells of the organ of Corti http://purl.obolibrary.org/obo/MP_0004398 cochlear inner hair cell degeneration http://purl.obolibrary.org/obo/MP_0004393 abnormal cochlear inner hair cell morphology degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti http://purl.obolibrary.org/obo/MP_0004399 abnormal cochlear outer hair cell morphology http://purl.obolibrary.org/obo/MP_0002622 abnormal cochlear hair cell morphology any structural anomaly in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell's surface through the cuticular plate into the tectorial membrane http://purl.obolibrary.org/obo/MP_0004400 abnormal cochlear outer hair cell number http://purl.obolibrary.org/obo/MP_0004399 abnormal cochlear outer hair cell morphology abnormal number of the columnar outer hair sensory cells of the organ of Corti http://purl.obolibrary.org/obo/MP_0004401 increased cochlear outer hair cell number http://purl.obolibrary.org/obo/MP_0004407 increased cochlear hair cell number increased number (or more than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti http://purl.obolibrary.org/obo/MP_0004402 decreased cochlear outer hair cell number http://purl.obolibrary.org/obo/MP_0004408 decreased cochlear hair cell number decreased number (or less than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti http://purl.obolibrary.org/obo/MP_0004403 absent cochlear outer hair cells http://purl.obolibrary.org/obo/MP_0004405 absent cochlear hair cells absence of the columnar outer hair sensory cells of the organ of Corti http://purl.obolibrary.org/obo/MP_0004404 cochlear outer hair cell degeneration http://purl.obolibrary.org/obo/MP_0004399 abnormal cochlear outer hair cell morphology degeneration or loss of the columnar outer hair sensory cells of the organ of Corti http://purl.obolibrary.org/obo/MP_0004405 absent cochlear hair cells http://purl.obolibrary.org/obo/MP_0004408 decreased cochlear hair cell number absence of the sensory epithelial cells of the cochlea; these cells are normally in synaptic contact with the auditory nerve http://purl.obolibrary.org/obo/MP_0004406 abnormal cochlear hair cell number http://purl.obolibrary.org/obo/MP_0002622 abnormal cochlear hair cell morphology abnormal number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve http://purl.obolibrary.org/obo/MP_0004407 increased cochlear hair cell number http://purl.obolibrary.org/obo/MP_0004406 abnormal cochlear hair cell number increased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve http://purl.obolibrary.org/obo/MP_0004408 decreased cochlear hair cell number http://purl.obolibrary.org/obo/MP_0004406 abnormal cochlear hair cell number decreased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve http://purl.obolibrary.org/obo/MP_0004409 abnormal crista ampullaris neuroepithelium morphology http://purl.obolibrary.org/obo/MP_0004249 abnormal crista ampullaris morphology any structural anomaly in the specialized sensory hair cells of the ampullary crest of the ampulla of each semicircular duct http://purl.obolibrary.org/obo/MP_0004410 absent endocochlear potential http://purl.obolibrary.org/obo/MP_0002630 abnormal endocochlear potential absence of the electrical potential difference between the endolymphatic and perilymphatic compartments of the cochlea, indicating a primary defect in fluid homeostasis of the inner ear http://purl.obolibrary.org/obo/MP_0004411 decreased endocochlear potential http://purl.obolibrary.org/obo/MP_0002630 abnormal endocochlear potential reduction of the electrical potential difference between the endolymphatic and perilymphatic compartments of the cochlea http://purl.obolibrary.org/obo/MP_0004412 abnormal cochlear microphonics http://purl.obolibrary.org/obo/MP_0006332 abnormal cochlear potential any anomaly in the bioelectric potentials produced by the hair cells of the organ of Corti in response to sound; the cochlear microphonic (CM) is an electric response dominated by OHC receptor potentials from the basal turn of the cochlea and provides a measure of transducer function in OHCs; in an active ear, CM waveforms show post-stimulus ringing (i.e. a cochlear echo) whereas in a passive ear system, CM decays at the cessation of the tone burst http://purl.obolibrary.org/obo/MP_0004413 absent cochlear microphonics http://purl.obolibrary.org/obo/MP_0004412 abnormal cochlear microphonics absence or loss of the bioelectric potentials produced by the hair cells of the organ of Corti in response to sound http://purl.obolibrary.org/obo/MP_0004414 decreased cochlear microphonics http://purl.obolibrary.org/obo/MP_0004412 abnormal cochlear microphonics reduction of the bioelectric potentials produced by the hair cells of the organ of Corti in response to sound http://purl.obolibrary.org/obo/MP_0004415 abnormal cochlear nerve compound action potential http://purl.obolibrary.org/obo/MP_0006335 abnormal hearing electrophysiology anomaly in the combined potentials resulting from activation of the auditory division of the eighth cranial nerve; these potentials represent the summed activity of multiple cochlear afferent fibers discharging synchronously and thus assess the combined functional state of OHCs, IHCs, and their primary afferent innervation http://purl.obolibrary.org/obo/MP_0004416 absent cochlear nerve compound action potential http://purl.obolibrary.org/obo/MP_0004415 abnormal cochlear nerve compound action potential absence of the combined potentials resulting from activation of the auditory division of the eighth cranial nerve http://purl.obolibrary.org/obo/MP_0004417 decreased cochlear nerve compound action potential http://purl.obolibrary.org/obo/MP_0004415 abnormal cochlear nerve compound action potential reduction of the combined potentials resulting from activation of the auditory division of the eighth cranial nerve http://purl.obolibrary.org/obo/MP_0004418 small parietal bone http://purl.obolibrary.org/obo/MP_0000109 abnormal parietal bone morphology reduced size of the curved bone forming part of the vault of the cranium http://purl.obolibrary.org/obo/MP_0004419 absent parietal bone http://purl.obolibrary.org/obo/MP_0000109 abnormal parietal bone morphology absence of the curved bone forming part of the vault of the cranium http://purl.obolibrary.org/obo/MP_0004420 parietal bone hypoplasia http://purl.obolibrary.org/obo/MP_0004418 small parietal bone underdevelopment or reduced size, usually due to a reduced number of cells, in the curved bone forming part of the vault of the cranium http://purl.obolibrary.org/obo/MP_0004421 enlarged parietal bone http://purl.obolibrary.org/obo/MP_0000109 abnormal parietal bone morphology increased size of the curved bone forming part of the vault of the cranium http://purl.obolibrary.org/obo/MP_0004422 small temporal bone http://purl.obolibrary.org/obo/MP_0005272 abnormal temporal bone morphology reduced size of the large, irregular bone located at the base and side of the skull http://purl.obolibrary.org/obo/MP_0004423 abnormal squamosal bone morphology http://purl.obolibrary.org/obo/MP_0005272 abnormal temporal bone morphology any structural anomaly of the thin, plate-like part of the temporal bone http://purl.obolibrary.org/obo/MP_0004424 temporal bone hypoplasia http://purl.obolibrary.org/obo/MP_0004422 small temporal bone underdevelopment or reduced size, usually due to a reduced number of cells, in the large, irregular bone located at the base and side of the skull http://purl.obolibrary.org/obo/MP_0004425 abnormal otolith organ morphology http://purl.obolibrary.org/obo/MP_0004427 abnormal vestibular labyrinth morphology any structural anomaly in the utricle and saccule of the inner ear which possess otoliths and respond to linear acceleration and deceleration, including gravity http://purl.obolibrary.org/obo/MP_0004428 abnormal type I vestibular cell http://purl.obolibrary.org/obo/MP_0002623 abnormal vestibular hair cell morphology any structural anomaly in the flask-shaped sensory cells of the maculae and cristae of the vestibular labyrinth of the inner ear, which are normally enclosed in calyx endings of afferent neurons; afferent and efferent nerve fibers of the vestibular nerve synapse with them; from the apical end of each cell a bundle of stereocilia and a kinocilium extend into the otolithic membrane of the maculae or the cupula of the cristae http://purl.obolibrary.org/obo/MP_0004429 abnormal type II vestibular cells http://purl.obolibrary.org/obo/MP_0002623 abnormal vestibular hair cell morphology any structural anomaly in the cylindrical sensory cells of the maculae and cristae of the vestibular labyrinth of the inner ear which are normally contacted by bouton endings of afferent and efferent neurons; afferent and efferent nerve fibers of the vestibular nerve synapse with them; from the apical end of each cell a bundle of stereocilia and a kinocilium extend into the otolithic membrane of the maculae or the cupula of the cristae http://purl.obolibrary.org/obo/MP_0004430 abnormal Claudius cell morphology http://purl.obolibrary.org/obo/MP_0003169 abnormal scala media morphology any structural anomaly in the columnar cells located on the floor of the ductus cochlearis external to the spiral organ (also known as the organ of Corti) http://purl.obolibrary.org/obo/MP_0004431 abnormal hair cell mechanoelectric transduction http://purl.obolibrary.org/obo/MP_0003879 abnormal hair cell physiology anomalous conversion of mechanical energy into electric(al) energy by sensory cells, such as auditory and vestibular hair cells, required for auditory sensation http://purl.obolibrary.org/obo/MP_0004432 abnormal cochlear hair cell physiology http://purl.obolibrary.org/obo/MP_0003879 abnormal hair cell physiology any functional anomaly in processes pertinent to the integrated function of cochlear hair cells i.e. the sensory cells in the spiral organ which are in synaptic contact with sensory as well as efferent fibers of the cochlear (auditory) nerve http://purl.obolibrary.org/obo/MP_0004433 abnormal cochlear inner hair cell physiology http://purl.obolibrary.org/obo/MP_0004432 abnormal cochlear hair cell physiology any functional anomaly in processes pertinent to the function of cochlear IHCs which constitute the true sensory cell type sending impulses via the cochlear (auditory) nerve http://purl.obolibrary.org/obo/MP_0004434 abnormal cochlear outer hair cell physiology http://purl.obolibrary.org/obo/MP_0004432 abnormal cochlear hair cell physiology any functional anomaly in processes pertinent to the function of cochlear OHCs which are known to enhance the performance of the cochlea, both qualitatively (increased selectivity) and quantitatively (increased sensitivity); in addition to the mechanoelectric transduction required for auditory sensation, OHCs also perform electromechanical transduction, whereby transmembrane voltage drives rapid changes in the length and stiffness of OHCs at audio frequencies in vitro (electromotility) http://purl.obolibrary.org/obo/MP_0004435 abnormal cochlear outer hair cell electromotility http://purl.obolibrary.org/obo/MP_0004434 abnormal cochlear outer hair cell physiology anomalous motility of the cochlear OHCs in response to electrical stimulation; normally, the motile response (i.e. rapid change in length and stiffness of OHCs) is closely coupled to the changing transduction current and provides a region-specific amplification in the movement of the spiral organ that enhances transduction at the IHCs in that specific region of the cochlear spiral, increasing both sensitivity and specificity; electromotility is believed to arise through voltage-gated conformational changes in motor protein (prestin) or proteins located in the lateral wall of the OHC http://purl.obolibrary.org/obo/MP_0004436 absent cochlear outer hair cell electromotility http://purl.obolibrary.org/obo/MP_0004435 abnormal cochlear outer hair cell electromotility absence or loss of motility of the cochlear OHCs in response to electrical stimulation http://purl.obolibrary.org/obo/MP_0004437 decreased cochlear outer hair cell electromotility http://purl.obolibrary.org/obo/MP_0004435 abnormal cochlear outer hair cell electromotility reduced motility of the cochlear OHCs in response to electrical stimulation http://purl.obolibrary.org/obo/MP_0004438 abnormal vestibular hair cell physiology http://purl.obolibrary.org/obo/MP_0003879 abnormal hair cell physiology anomalies in processes pertinent to the integrated function of the sensory epithelium of the maculae and cristae in the membranous labyrinth of the inner ear http://purl.obolibrary.org/obo/MP_0004439 absent Meckel's cartilage http://purl.obolibrary.org/obo/MP_0005587 abnormal Meckel's cartilage morphology absence of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments http://purl.obolibrary.org/obo/MP_0004440 absent occipital bone http://purl.obolibrary.org/obo/MP_0005269 abnormal occipital bone morphology absence of the bone at the lower, posterior part of the skull http://purl.obolibrary.org/obo/MP_0004441 small occipital bone http://purl.obolibrary.org/obo/MP_0005269 abnormal occipital bone morphology reduced size of the bone at the lower, posterior part of the skull http://purl.obolibrary.org/obo/MP_0004442 occipital bone foramen http://purl.obolibrary.org/obo/MP_0005269 abnormal occipital bone morphology presence of a hole in the bone at the lower, posterior part of the skull http://purl.obolibrary.org/obo/MP_0004443 absent supraoccipital bone http://purl.obolibrary.org/obo/MP_0000078 abnormal supraoccipital bone morphology absence of the bone on the dorsal side of the great foramen of the skull, usually forming a part of the occipital in the adult, but distinct in the young http://purl.obolibrary.org/obo/MP_0004444 small supraoccipital bone http://purl.obolibrary.org/obo/MP_0000078 abnormal supraoccipital bone morphology reduced size of the bone on the dorsal side of the great foramen of the skull, usually forming a part of the occipital in the adult, but distinct in the young http://purl.obolibrary.org/obo/MP_0004445 small exoccipital bone http://purl.obolibrary.org/obo/MP_0000080 abnormal exoccipital bone morphology reduced size of the bone or region on the lateral sides of the great foremen of the skull, which often forms a part of the occipital in the adult, but is usually distinct in the young http://purl.obolibrary.org/obo/MP_0004446 split exoccipital bone http://purl.obolibrary.org/obo/MP_0000080 abnormal exoccipital bone morphology the appearance of an abnormal division in the bone or region on the lateral sides of the great foremen of the skull, which often forms a part of the occipital in the adult, but is usually distinct in the young http://purl.obolibrary.org/obo/MP_0004447 small basioccipital bone http://purl.obolibrary.org/obo/MP_0000079 abnormal basioccipital bone morphology reduced size of the bone in the base of the cranium, frequently forming a part of the occipital in the adult, but usually distinct in the young http://purl.obolibrary.org/obo/MP_0004448 abnormal presphenoid bone morphology http://purl.obolibrary.org/obo/MP_0000104 abnormal sphenoid bone morphology any structural anomaly of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult http://purl.obolibrary.org/obo/MP_0004449 absent presphenoid bone http://purl.obolibrary.org/obo/MP_0004448 abnormal presphenoid bone morphology absence of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult http://purl.obolibrary.org/obo/MP_0004450 presphenoid bone hypoplasia http://purl.obolibrary.org/obo/MP_0004448 abnormal presphenoid bone morphology underdevelopment or reduced size, usually due to a reduced number of cells, of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult http://purl.obolibrary.org/obo/MP_0004451 short presphenoid bone http://purl.obolibrary.org/obo/MP_0004448 abnormal presphenoid bone morphology reduced length of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult http://purl.obolibrary.org/obo/MP_0004452 abnormal pterygoid process morphology http://purl.obolibrary.org/obo/MP_0000104 abnormal sphenoid bone morphology any structural anomaly of the process projecting downward from either side of the sphenoid bone, in vertebrates divided into two plates, an inner and an outer (sometimes called the lateral and medial); the posterior nares pass through the space, called the pterygoid fossa, between the processes http://purl.obolibrary.org/obo/MP_0004453 abnormal pterygoid bone morphology http://purl.obolibrary.org/obo/MP_0004452 abnormal pterygoid process morphology any structural anomaly of the bone region which corresponds to the inner plate of the pterygoid process of the mammalian skull http://purl.obolibrary.org/obo/MP_0004454 absent pterygoid process http://purl.obolibrary.org/obo/MP_0004452 abnormal pterygoid process morphology absence of the process projecting downward from either side of the sphenoid bone, in vertebrates divided into two plates, an inner and an outer (sometimes called the lateral and medial); the posterior nares pass through the space, called the pterygoid fossa, between the processes http://purl.obolibrary.org/obo/MP_0004455 pterygoid bone hypoplasia http://purl.obolibrary.org/obo/MP_0004456 small pterygoid bone underdevelopment or reduced size, usually due to a reduced number of cells, in the bone region which corresponds to the inner plate of the pterygoid process of the mammalian skull http://purl.obolibrary.org/obo/MP_0004456 small pterygoid bone http://purl.obolibrary.org/obo/MP_0004453 abnormal pterygoid bone morphology reduced size of the bone region which corresponds to the inner plate of the pterygoid process of the mammalian skull http://purl.obolibrary.org/obo/MP_0004457 abnormal orbitosphenoid bone morphology http://purl.obolibrary.org/obo/MP_0010030 abnormal orbit morphology any structural anomaly of the bone that is situated in the orbit on either side of the presphenoid; it generally forms a part of the sphenoid in the adult, and may be independent in the young http://purl.obolibrary.org/obo/MP_0004458 absent alisphenoid bone http://purl.obolibrary.org/obo/MP_0003235 abnormal alisphenoid bone morphology absence of the broad curved wing like expanses on each side of the sphenoid bone in adults; may exist independently in the young http://purl.obolibrary.org/obo/MP_0004459 small alisphenoid bone http://purl.obolibrary.org/obo/MP_0003235 abnormal alisphenoid bone morphology reduced size of either of the broad curved wing like expanses on each side of the sphenoid bone in adults; may exist independently in the young http://purl.obolibrary.org/obo/MP_0004460 alisphenoid bone hypoplasia http://purl.obolibrary.org/obo/MP_0004459 small alisphenoid bone underdevelopment or reduced size in either of the broad curved wing like expanses on each side of the sphenoid bone in adults, usually due to reduced cell number; this bone may exist independently in the young http://purl.obolibrary.org/obo/MP_0004461 basisphenoid bone hypoplasia http://purl.obolibrary.org/obo/MP_0004462 small basisphenoid bone underdevelopment or reduced size, usually due to reduced cell number, in part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone http://purl.obolibrary.org/obo/MP_0004462 small basisphenoid bone http://purl.obolibrary.org/obo/MP_0000106 abnormal basisphenoid bone morphology reduced size of part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone http://purl.obolibrary.org/obo/MP_0004463 basisphenoid bone foramen http://purl.obolibrary.org/obo/MP_0000106 abnormal basisphenoid bone morphology the presence of one or more holes in part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone http://purl.obolibrary.org/obo/MP_0004464 absent strial basal cell tight junctions http://purl.obolibrary.org/obo/MP_0004365 abnormal strial basal cell morphology absence of tight junctions from the basal cell layer of stria vascularis, resulting in destruction of the paracellular barrier between basal cells; loss of basal cell tight junctions renders the intrastrial space open to perilymph and abolishes its electrical isolation http://purl.obolibrary.org/obo/MP_0004465 degeneration of organ of Corti supporting cells http://purl.obolibrary.org/obo/MP_0004300 abnormal organ of Corti supporting cell morphology degeneration or loss of the highly differentiated epithelial cells with distinctive morphological features that surround all hair cells in the organ of Corti http://purl.obolibrary.org/obo/MP_0004466 short cochlear outer hair cells http://purl.obolibrary.org/obo/MP_0004399 abnormal cochlear outer hair cell morphology reduced height of the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve http://purl.obolibrary.org/obo/MP_0004467 absent zygomatic bone http://purl.obolibrary.org/obo/MP_0005270 abnormal zygomatic bone morphology absence of the quadrilateral bone that forms the prominence of the cheek http://purl.obolibrary.org/obo/MP_0004469 abnormal zygomatic arch morphology http://purl.obolibrary.org/obo/MP_0000074 abnormal neurocranium morphology any structural anomaly of the bony arch in vertebrates that extends along the side or front of the skull beneath the eye socket and is formed by the temporal process of the zygomatic bone and the zygomatic process of the temporal bone http://purl.obolibrary.org/obo/MP_0004471 short nasal bone http://purl.obolibrary.org/obo/MP_0004470 small nasal bone reduced length of either of two rectangular bone plates forming the bridge of the nose http://purl.obolibrary.org/obo/MP_0004472 broad nasal bone http://purl.obolibrary.org/obo/MP_0000102 abnormal nasal bone morphology increased width of either of two rectangular bone plates forming the bridge of the nose http://purl.obolibrary.org/obo/MP_0004473 absent nasal bone http://purl.obolibrary.org/obo/MP_0000102 abnormal nasal bone morphology absence of either of two rectangular bone plates forming the bridge of the nose http://purl.obolibrary.org/obo/MP_0004475 palatine bone hypoplasia http://purl.obolibrary.org/obo/MP_0005249 abnormal palatine bone morphology underdevelopment or reduced size, usually due to a reduced number of cells, in either of either of two irregularly L-shaped bones located posterior to the maxilla that in part forms the back of the hard palate, part of the nasal cavity and part of the floor of the orbits http://purl.obolibrary.org/obo/MP_0004476 absent palatine bone http://purl.obolibrary.org/obo/MP_0005249 abnormal palatine bone morphology absence of either of two irregularly L-shaped bones located posterior to the maxilla that in part forms the back of the hard palate, part of the nasal cavity and part of the floor of the orbits http://purl.obolibrary.org/obo/MP_0004477 turbinate hypoplasia http://purl.obolibrary.org/obo/MP_0002244 abnormal turbinate morphology underdevelopment or reduced size, usually due to a reduced number of cells, in the small curved bones that extends horizontally along the lateral wall of the nasal passage http://purl.obolibrary.org/obo/MP_0004478 increased testicular teratoma incidence http://purl.obolibrary.org/obo/MP_0006262 increased testis tumor incidence greater than the expected number of a usually benign tumor found in the testis that is the result of an anomaly of germ cell development, occurring in a specific population in a given time period; teratomas typically contains a diversity of tissues often representing all organ systems such as hair, teeth, bone, thyroid, or nerve tissue http://purl.obolibrary.org/obo/MP_0004479 abnormal oval window morphology http://purl.obolibrary.org/obo/MP_0000049 abnormal middle ear morphology any structural anomaly of the oval opening on the medial wall of the tympanic cavity leading into the vestibule, close to the foot of the stapes http://purl.obolibrary.org/obo/MP_0004480 abnormal round window morphology http://purl.obolibrary.org/obo/MP_0000049 abnormal middle ear morphology any structural anomaly of the opening on the medial wall of the middle ear leading into the cochlea, closed in life by the secondary tympanic membrane; serves to regulate fluid pressure in the inner ear http://purl.obolibrary.org/obo/MP_0004481 abnormal conjunctival epithelium morphology http://purl.obolibrary.org/obo/MP_0001310 abnormal conjunctiva morphology any structural anomaly of the conjunctival layer of epithelial cells covering inner surface of the eyelid and the front of the eyeball except over the cornea http://purl.obolibrary.org/obo/MP_0004482 abnormal interdental cell morphology http://purl.obolibrary.org/obo/MP_0004287 abnormal spiral limbus morphology any structural anomaly of the long, spindle-shaped cells arranged in parallel rows, oriented with their vertical axis perpendicular to the luminal surface of the spiral limbus; they secrete potassium ions into the endolymph and secrete the tectorial membrane http://purl.obolibrary.org/obo/MP_0004483 absent interdental cells http://purl.obolibrary.org/obo/MP_0004482 abnormal interdental cell morphology absence of the long, spindle-shaped cells arranged in parallel rows, oriented with their vertical axis perpendicular to the luminal surface of the spiral limbus; they secrete potassium ions into the endolymph and secrete the tectorial membrane http://purl.obolibrary.org/obo/MP_0004484 altered response of heart to induced stress http://purl.obolibrary.org/obo/MP_0005164 abnormal response to injury change in the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding http://purl.obolibrary.org/obo/MP_0004485 increased response of heart to induced stress http://purl.obolibrary.org/obo/MP_0004484 altered response of heart to induced stress increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding http://purl.obolibrary.org/obo/MP_0004486 decreased response of heart to induced stress http://purl.obolibrary.org/obo/MP_0004484 altered response of heart to induced stress decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding http://purl.obolibrary.org/obo/MP_0004487 type I spiral ligament fibrocyte degeneration http://purl.obolibrary.org/obo/MP_0004293 abnormal type I spiral ligament fibrocytes degeneration or loss of type I spiral ligament fibrocytes which occupy the region beneath the stria vascularis http://purl.obolibrary.org/obo/MP_0004488 type II spiral ligament fibrocyte degeneration http://purl.obolibrary.org/obo/MP_0004294 abnormal type II spiral ligament fibrocytes degeneration or loss of type II spiral ligament fibrocytes found in the suprastrial zone and the central area of the spiral ligament beneath the spiral prominence http://purl.obolibrary.org/obo/MP_0004489 type III spiral ligament fibrocyte degeneration http://purl.obolibrary.org/obo/MP_0004295 abnormal type III spiral ligament fibrocytes degeneration or loss of type III spiral ligament fibrocytes which form a cell layer attached to the otic capsule http://purl.obolibrary.org/obo/MP_0004490 type IV spiral ligament fibrocyte degeneration http://purl.obolibrary.org/obo/MP_0004296 abnormal type IV spiral ligament fibrocytes degeneration or loss of type IV spiral ligament fibrocytes found in the triangular space inferior to the basilar crest http://purl.obolibrary.org/obo/MP_0004491 abnormal orientation of outer hair cell stereociliary bundles http://purl.obolibrary.org/obo/MP_0004527 abnormal outer hair cell stereociliary bundle morphology misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium http://purl.obolibrary.org/obo/MP_0004492 abnormal orientation of inner hair cell stereociliary bundles http://purl.obolibrary.org/obo/MP_0004532 abnormal inner hair cell stereociliary bundle morphology misorientation or rotation of inner hair cell (IHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium http://purl.obolibrary.org/obo/MP_0004493 dilated cochlea http://purl.obolibrary.org/obo/MP_0000031 abnormal cochlea morphology the luminal space of the cochlea is increased in volume or area, usually with an increase in contained fluid http://purl.obolibrary.org/obo/MP_0004494 abnormal synaptic glutamate release http://purl.obolibrary.org/obo/MP_0005445 abnormal neurotransmitter secretion aberrant secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors http://purl.obolibrary.org/obo/MP_0004495 decreased synaptic glutamate release http://purl.obolibrary.org/obo/MP_0004494 abnormal synaptic glutamate release reduced secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors http://purl.obolibrary.org/obo/MP_0004496 abnormal organ of Corti supporting cell number http://purl.obolibrary.org/obo/MP_0004300 abnormal organ of Corti supporting cell morphology abnormal number of the highly differentiated epithelial cells with distinctive morphological features which surround the hair cells in the organ of Corti http://purl.obolibrary.org/obo/MP_0004498 increased organ of Corti supporting cell number http://purl.obolibrary.org/obo/MP_0004496 abnormal organ of Corti supporting cell number increased number of the highly differentiated epithelial cells with distinctive morphological features which surround the hair cells in the organ of Corti http://purl.obolibrary.org/obo/MP_0004499 increased incidence of tumors by chemical induction http://purl.obolibrary.org/obo/MP_0008873 increased physiological sensitivity to xenobiotic higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens http://purl.obolibrary.org/obo/MP_0004500 increased incidence of tumors by ionizing radiation induction http://purl.obolibrary.org/obo/MP_0002021 increased incidence of induced tumors higher than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays http://purl.obolibrary.org/obo/MP_0004501 increased incidence of tumors by UV-induction http://purl.obolibrary.org/obo/MP_0002021 increased incidence of induced tumors higher than normal frequency of tumor incidence induced by exposure to ultraviolet light http://purl.obolibrary.org/obo/MP_0004502 decreased incidence of tumors by chemical induction http://purl.obolibrary.org/obo/MP_0008874 decreased physiological sensitivity to xenobiotic lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens http://purl.obolibrary.org/obo/MP_0004503 decreased incidence of tumors by ionizing radiation induction http://purl.obolibrary.org/obo/MP_0002053 decreased incidence of induced tumors lower than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays http://purl.obolibrary.org/obo/MP_0004504 decreased incidence of tumors by UV induction http://purl.obolibrary.org/obo/MP_0002053 decreased incidence of induced tumors lower than normal frequency of tumor incidence induced by exposure to ultraviolet light http://purl.obolibrary.org/obo/MP_0004505 decreased renal glomerulus number http://purl.obolibrary.org/obo/MP_0005325 abnormal renal glomerulus morphology reduced number of the capillary loops of the kidney that normally function as a filtration unit http://purl.obolibrary.org/obo/MP_0004506 abnormal pubis morphology http://purl.obolibrary.org/obo/MP_0004509 abnormal pelvic girdle bone morphology any structural anomaly of the forward portion of either of the hipbones, at the juncture forming the front arch of the pelvis http://purl.obolibrary.org/obo/MP_0004507 abnormal ischium morphology http://purl.obolibrary.org/obo/MP_0004509 abnormal pelvic girdle bone morphology any structural anomaly of the lowest of the three major bones that constitute each half of the pelvis, distinct at birth but later becoming fused with the ilium and pubis http://purl.obolibrary.org/obo/MP_0004509 abnormal pelvic girdle bone morphology http://purl.obolibrary.org/obo/MP_0009250 abnormal appendicular skeleton morphology any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton http://purl.obolibrary.org/obo/MP_0004510 myositis http://purl.obolibrary.org/obo/MP_0002106 abnormal muscle physiology inflammation of muscle; local accumulation of fluid, plasma proteins, and leukocytes in muscle http://purl.obolibrary.org/obo/MP_0004512 anosmia http://purl.obolibrary.org/obo/MP_0001984 abnormal olfaction loss of the sense of smell http://purl.obolibrary.org/obo/MP_0004513 avnosmia http://purl.obolibrary.org/obo/MP_0005423 abnormal somatic nervous system physiology loss of the ability to detect pheromones through the vomeronasal system http://purl.obolibrary.org/obo/MP_0004514 dystocia http://purl.obolibrary.org/obo/MP_0002907 abnormal parturition slow or difficult delivery of offspring and/or placenta http://purl.obolibrary.org/obo/MP_0004515 abnormal vestibular hair cell stereociliary bundle morphology http://purl.obolibrary.org/obo/MP_0002623 abnormal vestibular hair cell morphology any structural anomaly or disruption of the typical staircase-like arrangement of the mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of vestibular hair cells of the utricle and saccule http://purl.obolibrary.org/obo/MP_0004516 fused vestibular hair cell stereocilia http://purl.obolibrary.org/obo/MP_0004515 abnormal vestibular hair cell stereociliary bundle morphology coalescence of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on vestibular hair cells, often resulting in giant stereocilia http://purl.obolibrary.org/obo/MP_0004517 decreased vestibular hair cell stereocilia number http://purl.obolibrary.org/obo/MP_0004515 abnormal vestibular hair cell stereociliary bundle morphology decreased number of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on vestibular hair cells in a staircase-like pattern http://purl.obolibrary.org/obo/MP_0004518 absent vestibular hair cell stereocilia http://purl.obolibrary.org/obo/MP_0004515 abnormal vestibular hair cell stereociliary bundle morphology complete absence of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on vestibular hair cells in a staircase-like pattern http://purl.obolibrary.org/obo/MP_0004519 thin vestibular hair cell stereocilia http://purl.obolibrary.org/obo/MP_0004515 abnormal vestibular hair cell stereociliary bundle morphology reduced thickness of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on vestibular hair cells in a staircase-like pattern http://purl.obolibrary.org/obo/MP_0004520 short vestibular hair cell stereocilia http://purl.obolibrary.org/obo/MP_0004515 abnormal vestibular hair cell stereociliary bundle morphology reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on vestibular hair cells in a staircase-like pattern http://purl.obolibrary.org/obo/MP_0004521 abnormal cochlear hair cell stereociliary bundle morphology http://purl.obolibrary.org/obo/MP_0002622 abnormal cochlear hair cell morphology any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells http://purl.obolibrary.org/obo/MP_0004522 abnormal orientation of cochlear hair cell stereociliary bundles http://purl.obolibrary.org/obo/MP_0004521 abnormal cochlear hair cell stereociliary bundle morphology misorientation or rotation of inner and/or outer hair cell stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium http://purl.obolibrary.org/obo/MP_0004523 decreased cochlear hair cell stereocilia number http://purl.obolibrary.org/obo/MP_0004521 abnormal cochlear hair cell stereociliary bundle morphology decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner and outer hair cells http://purl.obolibrary.org/obo/MP_0004524 short cochlear hair cell stereocilia http://purl.obolibrary.org/obo/MP_0004521 abnormal cochlear hair cell stereociliary bundle morphology reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner and outer hair cells http://purl.obolibrary.org/obo/MP_0004525 thin cochlear hair cell stereocilia http://purl.obolibrary.org/obo/MP_0004521 abnormal cochlear hair cell stereociliary bundle morphology reduced thickness of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner and outer hair cells http://purl.obolibrary.org/obo/MP_0004526 absent cochlear hair cell stereocilia http://purl.obolibrary.org/obo/MP_0004521 abnormal cochlear hair cell stereociliary bundle morphology complete absence of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner and outer hair cells http://purl.obolibrary.org/obo/MP_0004527 abnormal outer hair cell stereociliary bundle morphology http://purl.obolibrary.org/obo/MP_0004521 abnormal cochlear hair cell stereociliary bundle morphology any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia http://purl.obolibrary.org/obo/MP_0004528 fused outer hair cell stereocilia http://purl.obolibrary.org/obo/MP_0004527 abnormal outer hair cell stereociliary bundle morphology coalescence of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear outer hair cells, often resulting in giant stereocilia http://purl.obolibrary.org/obo/MP_0004529 decreased outer hair cell stereocilia number http://purl.obolibrary.org/obo/MP_0004527 abnormal outer hair cell stereociliary bundle morphology decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear outer hair cells http://purl.obolibrary.org/obo/MP_0004530 absent outer hair cell stereocilia http://purl.obolibrary.org/obo/MP_0004527 abnormal outer hair cell stereociliary bundle morphology complete absence of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear outer hair cells http://purl.obolibrary.org/obo/MP_0004531 short outer hair cell stereocilia http://purl.obolibrary.org/obo/MP_0004527 abnormal outer hair cell stereociliary bundle morphology reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear outer hair cells http://purl.obolibrary.org/obo/MP_0004532 abnormal inner hair cell stereociliary bundle morphology http://purl.obolibrary.org/obo/MP_0004521 abnormal cochlear hair cell stereociliary bundle morphology any structural anomaly or disruption of the typically linear or U-shaped pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear IHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia http://purl.obolibrary.org/obo/MP_0004533 fused inner hair cell stereocilia http://purl.obolibrary.org/obo/MP_0004532 abnormal inner hair cell stereociliary bundle morphology coalescence of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner hair cells, often resulting in giant stereocilia http://purl.obolibrary.org/obo/MP_0004534 decreased inner hair cell stereocilia number http://purl.obolibrary.org/obo/MP_0004532 abnormal inner hair cell stereociliary bundle morphology decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner hair cells http://purl.obolibrary.org/obo/MP_0004535 absent inner hair cell stereocilia http://purl.obolibrary.org/obo/MP_0004532 abnormal inner hair cell stereociliary bundle morphology complete absence of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner hair cells http://purl.obolibrary.org/obo/MP_0004536 short inner hair cell stereocilia http://purl.obolibrary.org/obo/MP_0004532 abnormal inner hair cell stereociliary bundle morphology reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner hair cells http://purl.obolibrary.org/obo/MP_0004539 absent maxilla http://purl.obolibrary.org/obo/MP_0000455 abnormal maxilla morphology missing the upper bony framework of the mouth where the superior teeth are held http://purl.obolibrary.org/obo/MP_0004541 absent auditory tube http://purl.obolibrary.org/obo/MP_0003330 abnormal auditory tube absence of the tube connecting the tympanic cavity and the nasopharynx http://purl.obolibrary.org/obo/MP_0004542 impaired acrosome reaction http://purl.obolibrary.org/obo/MP_0013287 abnormal acrosome reaction reduced ability or inability to execute the cellular exocytosis of a single, anterior secretory granule following a sperm's attachment to the zona pellucida surrounding an oocyte http://purl.obolibrary.org/obo/MP_0004544 absent esophagus http://purl.obolibrary.org/obo/MP_0000467 abnormal esophagus morphology absence of the part of the digestive canal through which food passes from the pharynx to the stomach http://purl.obolibrary.org/obo/MP_0004545 enlarged esophagus http://purl.obolibrary.org/obo/MP_0000467 abnormal esophagus morphology increased size of the part of the digestive canal through which food passes from the pharynx to the stomach http://purl.obolibrary.org/obo/MP_0004546 esophagus hyperplasia http://purl.obolibrary.org/obo/MP_0004545 enlarged esophagus overdevelopment or increased size, usually due an increased number of cells of the esophagus http://purl.obolibrary.org/obo/MP_0004547 esophageal ulcer http://purl.obolibrary.org/obo/MP_0000467 abnormal esophagus morphology a lesion on the mucosal surface of the esophagus, usually produced by the sloughing of inflammatory necrotic tissue http://purl.obolibrary.org/obo/MP_0004548 dilated esophagus http://purl.obolibrary.org/obo/MP_0000467 abnormal esophagus morphology an expansion in the lumen volume of the part of the digestive canal through which food passes from the pharynx to the stomach http://purl.obolibrary.org/obo/MP_0004549 small trachea http://purl.obolibrary.org/obo/MP_0002282 abnormal trachea morphology reduced size of the tube descending from the larynx and branching into the right and left main bronchi http://purl.obolibrary.org/obo/MP_0004550 short trachea http://purl.obolibrary.org/obo/MP_0004549 small trachea reduced length of the tube descending from the larynx and branching into the right and left main bronchi http://purl.obolibrary.org/obo/MP_0004551 decreased tracheal cartilage ring number http://purl.obolibrary.org/obo/MP_0003120 abnormal tracheal cartilage morphology less than the 16-20 incomplete rings of hyaline cartilage forming the skeleton of the trachea http://purl.obolibrary.org/obo/MP_0004552 fused tracheal cartilage rings http://purl.obolibrary.org/obo/MP_0003120 abnormal tracheal cartilage morphology fusion of the 16-20 incomplete rings of hyaline cartilage that form the skeleton of the trachea http://purl.obolibrary.org/obo/MP_0004553 absent tracheal cartilage rings http://purl.obolibrary.org/obo/MP_0003120 abnormal tracheal cartilage morphology absence of the 16-20 incomplete rings of hyaline cartilage forming the skeleton of the trachea http://purl.obolibrary.org/obo/MP_0004554 small pharynx http://purl.obolibrary.org/obo/MP_0002234 abnormal pharynx morphology reduced size of the passage between the mouth and the posterior nares and the larynx and esophagus http://purl.obolibrary.org/obo/MP_0004555 pharynx hypoplasia http://purl.obolibrary.org/obo/MP_0004554 small pharynx underdevelopment or reduced size, usually due to a reduced number of cells, of the passage between the mouth and the posterior nares and the larynx and esophagus http://purl.obolibrary.org/obo/MP_0004556 enlarged allantois http://purl.obolibrary.org/obo/MP_0001726 abnormal allantois morphology increased size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels http://purl.obolibrary.org/obo/MP_0004557 dilated allantois http://purl.obolibrary.org/obo/MP_0001726 abnormal allantois morphology an expansion in the volume of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels, as by stretching or distention http://purl.obolibrary.org/obo/MP_0004558 delayed allantois development http://purl.obolibrary.org/obo/MP_0001726 abnormal allantois morphology late onset of development of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels http://purl.obolibrary.org/obo/MP_0004559 small allantois http://purl.obolibrary.org/obo/MP_0001726 abnormal allantois morphology reduced size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels http://purl.obolibrary.org/obo/MP_0004560 abnormal chorionic plate morphology http://purl.obolibrary.org/obo/MP_0002836 abnormal chorion morphology any structural anomaly of the portion of the chorion from which chorionic villi develop that establish a connection with the endometrium, giving rise to the fetal portion of the mature placenta http://purl.obolibrary.org/obo/MP_0004561 absent facial nerve http://purl.obolibrary.org/obo/MP_0001071 abnormal facial nerve morphology absence of the sensory and motor nerve that supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue http://purl.obolibrary.org/obo/MP_0004562 abnormal inner hair cell synaptic ribbon morphology http://purl.obolibrary.org/obo/MP_0004393 abnormal cochlear inner hair cell morphology any structural anomaly in the presynaptic active zone of mature cochlear IHCs which usually contain a single synaptic ribbon, i.e. a submicrometer, electron-dense structure tethering synaptic vesicles; each spiral ganglion neuron receives input from only one IHC synapse http://purl.obolibrary.org/obo/MP_0004563 absent active-zone-anchored inner hair cell synaptic ribbon http://purl.obolibrary.org/obo/MP_0004562 abnormal inner hair cell synaptic ribbon morphology absence or loss of the usually single synaptic ribbon, a characteristic osmiophilic, electron-dense structure to which synaptic vesicles are tethered at the active zone of the cochlear inner hair cell afferent synapse http://purl.obolibrary.org/obo/MP_0004564 enlarged myocardial fiber http://purl.obolibrary.org/obo/MP_0000278 abnormal myocardial fiber morphology increased size of the terminally differentiated, non-proliferative, cardiac muscle fibers, the multinucleated muscle cells of the heart http://purl.obolibrary.org/obo/MP_0004565 small myocardial fiber http://purl.obolibrary.org/obo/MP_0000278 abnormal myocardial fiber morphology decreased size of the terminally differentiated, non-proliferative, cardiac muscle fibers, the multinucleated muscle cells of the heart http://purl.obolibrary.org/obo/MP_0004566 myocardial fiber degeneration http://purl.obolibrary.org/obo/MP_0000278 abnormal myocardial fiber morphology deterioration or destruction of the terminally differentiated, non-proliferative, cardiac muscle fibers, the multinucleated muscle cells of the heart http://purl.obolibrary.org/obo/MP_0004567 decreased myocardial fiber number http://purl.obolibrary.org/obo/MP_0000278 abnormal myocardial fiber morphology decreased number of the terminally differentiated, non-proliferative, cardiac muscle fibers, the multinucleated muscle cells of the heart http://purl.obolibrary.org/obo/MP_0004568 fusion of glossopharyngeal and vagus nerve http://purl.obolibrary.org/obo/MP_0001074 abnormal vagus nerve morphology union of the ninth and tenth cranial nerves into a single structure http://purl.obolibrary.org/obo/MP_0004569 glossopharyngeal nerve hypoplasia http://purl.obolibrary.org/obo/MP_0001073 abnormal glossopharyngeal nerve morphology underdevelopment or reduced size, usually due to a reduced number of cells, of the sensory and autonomic axons to the parotid gland, carotid body, posterior third of the tongue; the branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion http://purl.obolibrary.org/obo/MP_0004570 absent glossopharyngeal nerve http://purl.obolibrary.org/obo/MP_0001073 abnormal glossopharyngeal nerve morphology absence of the sensory and autonomic axons to the parotid gland, carotid body, posterior third of the tongue; the branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion http://purl.obolibrary.org/obo/MP_0004571 absent vagus nerve http://purl.obolibrary.org/obo/MP_0001074 abnormal vagus nerve morphology absence of the autonomic, sensory and motor axons of the tenth cranial nerve; it is primarily sensory but also has visceromotor components; it originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components, and also controls some motor functions such as speech; the sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis http://purl.obolibrary.org/obo/MP_0004572 fusion of basioccipital and basisphenoid bone http://purl.obolibrary.org/obo/MP_0000106 abnormal basisphenoid bone morphology union of the basioccipital and basisphenoid bones into one structure, when this fusion does not normally occur (such as in a species where these bones normally persist as separate entities) http://purl.obolibrary.org/obo/MP_0004573 absent limb buds http://purl.obolibrary.org/obo/MP_0005650 abnormal limb bud morphology missing the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs http://purl.obolibrary.org/obo/MP_0004574 broad limb buds http://purl.obolibrary.org/obo/MP_0005650 abnormal limb bud morphology increased anterior-posterior width of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs http://purl.obolibrary.org/obo/MP_0004575 small limb buds http://purl.obolibrary.org/obo/MP_0005650 abnormal limb bud morphology reduced size of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs http://purl.obolibrary.org/obo/MP_0004576 abnormal foot plate morphology http://purl.obolibrary.org/obo/MP_0006279 abnormal limb development any structural anomaly of the distal elements of the developing limb of vertebrates that will give rise to the pedal appendages (e.g. hand, foot, paw) http://purl.obolibrary.org/obo/MP_0004577 abnormal cochlear hair cell inter-stereocilial links morphology http://purl.obolibrary.org/obo/MP_0004521 abnormal cochlear hair cell stereociliary bundle morphology any structural anomaly in the morphologically and biochemically distinct link types that extend between the stereocilia of cochlear hair bundles; link types can be distinguished by their relative sensitivities to treatment with calcium chelators and the protease subtilisin; in the mature mouse cochlea, tip links and horizontal top connectors are the only inter-stereocilial links associated with the hair bundle; ankle links and transient lateral links are both prominent features of developing auditory hair bundles http://purl.obolibrary.org/obo/MP_0004578 abnormal cochlear hair bundle tip links morphology http://purl.obolibrary.org/obo/MP_0004577 abnormal cochlear hair cell inter-stereocilial links morphology any structural anomaly in single, three-stranded interrow filaments that extend obliquely from the tip of one stereocilium to the lateral side of an adjacent taller stereocilium; in the mouse, tip links are already detectable prenatally and persist throughout life; tips links are thought to gate the mechanotransducer channel, are lost from the cell surface after exposure to either calcium chelator BAPTA or lanthanum, and resist degradation by the protease subtilisin http://purl.obolibrary.org/obo/MP_0004579 abnormal cochlear hair bundle horizontal top connectors morphology http://purl.obolibrary.org/obo/MP_0004577 abnormal cochlear hair cell inter-stereocilial links morphology any structural anomaly in the inter-stereocilial links that connect the top of a shorter stereocilium to an adjacent longer stereocilium at a short distance below the tip links; the appearance of horizontal top connectors, which persist into adulthood, occurs concomitant with this loss of ankle links; top connectors are essentially unaffected by treatment with subtilisin and EGTA http://purl.obolibrary.org/obo/MP_0004580 abnormal cochlear hair bundle transient lateral links morphology http://purl.obolibrary.org/obo/MP_0004577 abnormal cochlear hair cell inter-stereocilial links morphology any structural anomaly in the fine lateral links that interconnect stereocilia at prenatal stages; transient lateral links diminish at early postnatal stages when ankle links appear at the base of stereocilia, and are essentially unaffected by treatment with subtilisin and EGTA http://purl.obolibrary.org/obo/MP_0004581 abnormal cochlear hair bundle ankle links morphology http://purl.obolibrary.org/obo/MP_0004577 abnormal cochlear hair cell inter-stereocilial links morphology any structural anomaly in the long, single-stranded filaments that form a dense web or mesh around the base of cochlear hair bundles just above the region in which the stereocilia begin to taper down; in the mouse, ankle links are only a transient feature of the developing cochlear hair bundles, present predominantly from P2 though P9, but are absent by P12; ankle links are disrupted by treatment of hair cells with EGTA and subtilisin but not by La3+ and elastase http://purl.obolibrary.org/obo/MP_0004582 absent cochlear hair bundle ankle links http://purl.obolibrary.org/obo/MP_0004581 abnormal cochlear hair bundle ankle links morphology absence of the long, single-stranded filaments that form a dense web or mesh around the base of cochlear hair bundles just above the region in which the stereocilia begin to taper down http://purl.obolibrary.org/obo/MP_0004583 abnormal vestibular hair bundle inter-stereocilial links http://purl.obolibrary.org/obo/MP_0004515 abnormal vestibular hair cell stereociliary bundle morphology any structural anomaly in the morphologically and biochemically distinct link types that extend between the stereocilia of vestibular hair bundles http://purl.obolibrary.org/obo/MP_0004584 abnormal vestibular hair bundle shaft connectors http://purl.obolibrary.org/obo/MP_0004583 abnormal vestibular hair bundle inter-stereocilial links any structural anomaly in the links that connect the shafts of neighboring stereocilia in vestibular hair bundles; each shaft connector is composed of a ruthenium red-reactive, electron-dense particle that is connected to the plasma membrane by several fine strands of variable length http://purl.obolibrary.org/obo/MP_0004585 absent vestibular hair bundle shaft connectors http://purl.obolibrary.org/obo/MP_0004584 abnormal vestibular hair bundle shaft connectors absence of the inter-stereocilial links that connect the shafts of neighboring stereocilia in vestibular hair bundles http://purl.obolibrary.org/obo/MP_0004586 pillar cell degeneration http://purl.obolibrary.org/obo/MP_0003825 abnormal pillar cell morphology degeneration or loss of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti http://purl.obolibrary.org/obo/MP_0004587 decreased cellular sensitivity to X-ray irradiation http://purl.obolibrary.org/obo/MP_0004228 decreased cellular sensitivity to ionizing radiation decreased incidence of cell death following exposure to X-ray irradiation http://purl.obolibrary.org/obo/MP_0004588 abnormal vestibular hair cell development http://purl.obolibrary.org/obo/MP_0003938 abnormal ear development atypical initial production, differentiation, migration or maturation of hair cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the inner ear http://purl.obolibrary.org/obo/MP_0004589 abnormal cochlear hair cell development http://purl.obolibrary.org/obo/MP_0003938 abnormal ear development atypical initial production, differentiation, migration or maturation of the sensory epithelial cells of the cochlea http://purl.obolibrary.org/obo/MP_0004590 absent Deiters cells http://purl.obolibrary.org/obo/MP_0004302 abnormal Deiters cell morphology absence of the supporting cells of the spiral organ which are attached to the basement membrane and receive the hair cells between their free extremities http://purl.obolibrary.org/obo/MP_0004591 enlarged tectorial membrane http://purl.obolibrary.org/obo/MP_0003149 abnormal tectorial membrane morphology increased size of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells http://purl.obolibrary.org/obo/MP_0004593 long mandible http://purl.obolibrary.org/obo/MP_0000458 abnormal mandible morphology increased length of the lower bony framework of the mouth where the inferior teeth are held http://purl.obolibrary.org/obo/MP_0004594 abnormal mandibular coronoid process morphology http://purl.obolibrary.org/obo/MP_0010150 abnormal mandibule ramus morphology any structural anomaly of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion); includes the attachment site to the temporal muscle http://purl.obolibrary.org/obo/MP_0004595 abnormal mandibular condyloid process morphology http://purl.obolibrary.org/obo/MP_0010150 abnormal mandibule ramus morphology any structural anomaly of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint http://purl.obolibrary.org/obo/MP_0004596 abnormal mandibular angle morphology http://purl.obolibrary.org/obo/MP_0000458 abnormal mandible morphology any structural anomaly of the portion of the mandible where the body of the mandible (horizontal portion) and the rami (perpendicular portions) meet; these normally unite nearly at right angles http://purl.obolibrary.org/obo/MP_0004597 increased susceptibility to noise-induced hearing loss http://purl.obolibrary.org/obo/MP_0006334 abnormal susceptibility to hearing loss greater than normal reduction in hearing sensitivity following exposure to acute noise that is injurious to the cochlea http://purl.obolibrary.org/obo/MP_0004598 abnormal cochlear basement membrane morphology http://purl.obolibrary.org/obo/MP_0004272 abnormal basement membrane morphology any structural anomaly in the continuous basement membrane found within the membranous labyrinth of the cochlea, known to extend from the limbus, down to the inner sulcus, across the basilar membrane, up to the external sulcus to the spiral prominence and radiating into the spiral ligament ensheathing the root cell processes http://purl.obolibrary.org/obo/MP_0004599 abnormal vertebral arch morphology http://purl.obolibrary.org/obo/MP_0000137 abnormal vertebrae morphology any structural anomaly of the dorsal bony and/or cartilaginous part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process) http://purl.obolibrary.org/obo/MP_0004601 abnormal vertebral spinous process morphology http://purl.obolibrary.org/obo/MP_0004599 abnormal vertebral arch morphology any structural anomaly of the dorsal projection of the vertebral arch that projects backward and downward from the junction of the laminae, and serves for the attachment of muscles and ligaments http://purl.obolibrary.org/obo/MP_0004602 abnormal vertebral articular process morphology http://purl.obolibrary.org/obo/MP_0004599 abnormal vertebral arch morphology any structural anomaly of the bilateral flat projections that arise from the junctions of the pedicles and laminae http://purl.obolibrary.org/obo/MP_0004603 absent vertebral arch http://purl.obolibrary.org/obo/MP_0004599 abnormal vertebral arch morphology loss of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process) http://purl.obolibrary.org/obo/MP_0004605 abnormal vertebral lamina morphology http://purl.obolibrary.org/obo/MP_0004599 abnormal vertebral arch morphology any structural anomaly of two broad plates directed dorsomedially from the pedicles; these fuse at the dorsal midline, and complete the dorsal wall of the vertebral foramen http://purl.obolibrary.org/obo/MP_0004606 absent vertebral spinous process http://purl.obolibrary.org/obo/MP_0004601 abnormal vertebral spinous process morphology missing the dorsal projection of the vertebral arch that projects backward and downward from the junction of the laminae, and serves for the attachment of muscles and ligaments http://purl.obolibrary.org/obo/MP_0004607 abnormal cervical atlas morphology http://purl.obolibrary.org/obo/MP_0003048 abnormal cervical vertebrae morphology any structural anomaly of the first (topmost, C1) cervical vertebra which supports the globe of the head http://purl.obolibrary.org/obo/MP_0004608 abnormal cervical axis morphology http://purl.obolibrary.org/obo/MP_0003048 abnormal cervical vertebrae morphology any structural anomaly of the second cervical vertebra (C2) which forms the pivot upon which the first cervical (atlas, C1) vertebra rotates http://purl.obolibrary.org/obo/MP_0004609 vertebral fusion http://purl.obolibrary.org/obo/MP_0003189 fused joints the union of one or more vertebrae into a single structure http://purl.obolibrary.org/obo/MP_0004610 small vertebrae http://purl.obolibrary.org/obo/MP_0000137 abnormal vertebrae morphology reduced size of the bony segments of the spinal column http://purl.obolibrary.org/obo/MP_0004611 increased susceptibility to ototoxicity-induced hearing loss http://purl.obolibrary.org/obo/MP_0008873 increased physiological sensitivity to xenobiotic greater than normal reduction in hearing sensitivity following exposure to an ototoxic compound, such as aminoglycoside-induced hearing loss mediated via a glutamate excitotoxic process http://purl.obolibrary.org/obo/MP_0004612 fusion of vertebral bodies http://purl.obolibrary.org/obo/MP_0004609 vertebral fusion improper union of the main cylindrical portion of adjacent vertebra ventral to the vertebral canal http://purl.obolibrary.org/obo/MP_0004613 fusion of vertebral arches http://purl.obolibrary.org/obo/MP_0004609 vertebral fusion improper union of the dorsal part of adjacent vertebra http://purl.obolibrary.org/obo/MP_0004614 caudal vertebral transformation http://purl.obolibrary.org/obo/MP_0003036 vertebral transformation homeotic transformation of any caudal vertebrae to adopt the fate of another vertebrae http://purl.obolibrary.org/obo/MP_0004615 cervical vertebral transformation http://purl.obolibrary.org/obo/MP_0003048 abnormal cervical vertebrae morphology homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae http://purl.obolibrary.org/obo/MP_0004616 lumbar vertebral transformation http://purl.obolibrary.org/obo/MP_0003049 abnormal lumbar vertebrae morphology homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae http://purl.obolibrary.org/obo/MP_0004617 sacral vertebral transformation http://purl.obolibrary.org/obo/MP_0003050 abnormal sacral vertebrae morphology homeotic transformation of any sacral vertebrae to adopt the fate of another vertebrae http://purl.obolibrary.org/obo/MP_0004618 thoracic vertebral transformation http://purl.obolibrary.org/obo/MP_0003047 abnormal thoracic vertebrae morphology homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae http://purl.obolibrary.org/obo/MP_0004619 caudal vertebral fusion http://purl.obolibrary.org/obo/MP_0004609 vertebral fusion the union of one or more caudal vertebrae into a single structure in species where this does not normally occur http://purl.obolibrary.org/obo/MP_0004620 cervical vertebral fusion http://purl.obolibrary.org/obo/MP_0004609 vertebral fusion the union of one or more cervical vertebrae into a single structure http://purl.obolibrary.org/obo/MP_0004621 lumbar vertebral fusion http://purl.obolibrary.org/obo/MP_0004609 vertebral fusion the union of one or more lumbar vertebrae into a single structure http://purl.obolibrary.org/obo/MP_0004622 sacral vertebral fusion http://purl.obolibrary.org/obo/MP_0004609 vertebral fusion the union of one or more sacral vertebrae into a single structure in species where this does not normally occur http://purl.obolibrary.org/obo/MP_0004623 thoracic vertebral fusion http://purl.obolibrary.org/obo/MP_0004609 vertebral fusion the union of one or more thoracic vertebrae into a single structure http://purl.obolibrary.org/obo/MP_0004626 vertebral compression http://purl.obolibrary.org/obo/MP_0000137 abnormal vertebrae morphology appearance of vertebrae that are flattened laterally along the whole length such that they appear pressed together and take up less rostrocaudal space http://purl.obolibrary.org/obo/MP_0004627 abnormal trochanter morphology http://purl.obolibrary.org/obo/MP_0000559 abnormal femur morphology any structural anomaly of the bony prominences near the upper extremity of the femur; there are two in human (greater and lesser trochanters) and three in many other mammalian species (greater, lesser and third); these normally serve as attachment points for hip and thigh muscles http://purl.obolibrary.org/obo/MP_0004628 Deiters cell degeneration http://purl.obolibrary.org/obo/MP_0004302 abnormal Deiters cell morphology degeneration or loss of the supporting cells of the spiral organ which are attached to the basement membrane and receive the hair cells between their free extremities http://purl.obolibrary.org/obo/MP_0004629 abnormal spiral modiolar artery morphology http://purl.obolibrary.org/obo/MP_0011655 abnormal systemic artery morphology any structural anomaly of the artery which parallels the spiral ganglion in the root of the spiral lamina of the modiolus, serving the ganglion and the cochlear duct and its contents http://purl.obolibrary.org/obo/MP_0004630 spiral modiolar artery stenosis http://purl.obolibrary.org/obo/MP_0004629 abnormal spiral modiolar artery morphology abnormal narrowing of the artery which parallels the spiral ganglion in the root of the spiral lamina of the modiolus and serves the ganglion and the cochlear duct and its contents http://purl.obolibrary.org/obo/MP_0004632 abnormal cochlear OHC efferent innervation pattern http://purl.obolibrary.org/obo/MP_0004399 abnormal cochlear outer hair cell morphology any changes in the morphology or number of efferent terminals, occurring as clusters, in the cochlear OHC region; normally, medial olivocochlear neurons, which are primarily found in rostral and ventral periolivary regions, project mainly to the contralateral cochlea, and terminate directly on OHCs http://purl.obolibrary.org/obo/MP_0004633 abnormal cochlear IHC efferent innervation pattern http://purl.obolibrary.org/obo/MP_0004393 abnormal cochlear inner hair cell morphology any changes in the morphology of the normally dense plexus of efferent terminals that contact radial fibers of the spiral ganglion below cochlear IHCs or of the sparser plexus of terminals positioned around IHC somata; normally, lateral olivocochlear neurons, which are found in and/or around the lateral superior olive, project mainly to the ipsilateral cochlea and terminate mostly on dendritic fibers below IHCs http://purl.obolibrary.org/obo/MP_0004634 short metacarpal bones http://purl.obolibrary.org/obo/MP_0004686 decreased length of long bones reduced length of the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phalanges http://purl.obolibrary.org/obo/MP_0004635 short metatarsal bones http://purl.obolibrary.org/obo/MP_0004686 decreased length of long bones reduced length of the five bones of the hindpaws that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges http://purl.obolibrary.org/obo/MP_0004636 decreased metacarpal bone number http://purl.obolibrary.org/obo/MP_0003073 abnormal metacarpal bone morphology reduced number of the five bones of the forepaws/hands that articulate proximally with the carpal bones and distally with the phalanges http://purl.obolibrary.org/obo/MP_0004637 metacarpal bone hypoplasia http://purl.obolibrary.org/obo/MP_0003073 abnormal metacarpal bone morphology underdevelopment or reduced size, usually due to a reduced number of cells, of the five bones of the forepaws/hands that articulate proximally with the carpal bones and distally with the phalanges http://purl.obolibrary.org/obo/MP_0004638 elongated metacarpal bones http://purl.obolibrary.org/obo/MP_0004695 increased length of long bones increased length of the five bones of the forepaws/hands that articulate proximally with the carpal bones and distally with the phalanges http://purl.obolibrary.org/obo/MP_0004639 fused metacarpal bones http://purl.obolibrary.org/obo/MP_0003073 abnormal metacarpal bone morphology improper union of one or more of the five bones of the forepaws/hands that articulate proximally with the carpal bones and distally with the phalanges http://purl.obolibrary.org/obo/MP_0004640 decreased metatarsal bone number http://purl.obolibrary.org/obo/MP_0003072 abnormal metatarsal bone morphology reduced number of the five bones of the hindpaws/feet that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges http://purl.obolibrary.org/obo/MP_0004641 elongated metatarsal bones http://purl.obolibrary.org/obo/MP_0004695 increased length of long bones increased length of the five bones of the hindpaws/feet that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges http://purl.obolibrary.org/obo/MP_0004642 fused metatarsal bones http://purl.obolibrary.org/obo/MP_0003072 abnormal metatarsal bone morphology improper union of the five bones of the hindpaws/feet that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges http://purl.obolibrary.org/obo/MP_0004643 abnormal vertebrae number http://purl.obolibrary.org/obo/MP_0000137 abnormal vertebrae morphology altered number of the bony segments of the spinal column http://purl.obolibrary.org/obo/MP_0004646 decreased cervical vertebrae number http://purl.obolibrary.org/obo/MP_0003048 abnormal cervical vertebrae morphology reduced number of the seven bony segments of the spine located anterior to the thoracic vertebrae and caudal to the skull http://purl.obolibrary.org/obo/MP_0004647 decreased lumbar vertebrae number http://purl.obolibrary.org/obo/MP_0003049 abnormal lumbar vertebrae morphology reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae http://purl.obolibrary.org/obo/MP_0004648 decreased thoracic vertebrae number http://purl.obolibrary.org/obo/MP_0003047 abnormal thoracic vertebrae morphology reduced number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae http://purl.obolibrary.org/obo/MP_0004649 decreased sacral vertebrae number http://purl.obolibrary.org/obo/MP_0004645 decreased vertebrae number reduced number of the bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae http://purl.obolibrary.org/obo/MP_0004650 increased lumbar vertebrae number http://purl.obolibrary.org/obo/MP_0003049 abnormal lumbar vertebrae morphology increased number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae http://purl.obolibrary.org/obo/MP_0004651 increased thoracic vertebrae number http://purl.obolibrary.org/obo/MP_0003047 abnormal thoracic vertebrae morphology increased number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae http://purl.obolibrary.org/obo/MP_0004652 small caudal vertebrae http://purl.obolibrary.org/obo/MP_0002759 abnormal caudal vertebrae morphology reduced size of the bony segments of the coccyx or tail http://purl.obolibrary.org/obo/MP_0004653 absent caudal vertebrae http://purl.obolibrary.org/obo/MP_0002759 abnormal caudal vertebrae morphology absence of all of the bony segments of the coccyx or tail http://purl.obolibrary.org/obo/MP_0004654 absent lumbar vertebrae http://purl.obolibrary.org/obo/MP_0003049 abnormal lumbar vertebrae morphology absence of all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae http://purl.obolibrary.org/obo/MP_0004655 absent thoracic vertebrae http://purl.obolibrary.org/obo/MP_0003047 abnormal thoracic vertebrae morphology absence of all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae http://purl.obolibrary.org/obo/MP_0004656 absent sacral vertebrae http://purl.obolibrary.org/obo/MP_0003050 abnormal sacral vertebrae morphology absence of all of the bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae http://purl.obolibrary.org/obo/MP_0004657 small sacral vertebrae http://purl.obolibrary.org/obo/MP_0003050 abnormal sacral vertebrae morphology reduced size of any or all of the bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae http://purl.obolibrary.org/obo/MP_0004658 abnormal ventral tubercle of atlas morphology http://purl.obolibrary.org/obo/MP_0004607 abnormal cervical atlas morphology any structural anomaly of the conical ventral projection on the arch of the atlas http://purl.obolibrary.org/obo/MP_0004659 abnormal odontoid process morphology http://purl.obolibrary.org/obo/MP_0004608 abnormal cervical axis morphology any structural anomaly of the large protuberance that projects upward from the cervical axis, around which the cervical atlas rotates http://purl.obolibrary.org/obo/MP_0004660 absent thyroid follicular cells http://purl.obolibrary.org/obo/MP_0004697 abnormal thyroid follicular cell morphology absence of the thyroxine-producing follicular cells derived from the thyroid diverticulum which evaginates from the endodermal epithelium of the embryonic pharyngeal floor http://purl.obolibrary.org/obo/MP_0004661 absent thyroid parafollicular C-cells http://purl.obolibrary.org/obo/MP_0004698 abnormal thyroid parafollicular C-cell morphology absence of the calcitonin-producing C-cells which are derived from the ultimobranchial body (a sac-like structure emanating from the neural crest) and constitute the minor component of the thyroid gland http://purl.obolibrary.org/obo/MP_0004662 abnormal thyroid diverticulum morphology http://purl.obolibrary.org/obo/MP_0003421 abnormal thyroid gland development any structural anomaly in the endodermal bud derived from the endodermal epithelium of the embryonic pharyngeal floor http://purl.obolibrary.org/obo/MP_0004663 athyroidism http://purl.obolibrary.org/obo/MP_0000681 abnormal thyroid gland morphology congenital absence of the thyroid gland or suppression or absence of its hormonal secretion http://purl.obolibrary.org/obo/MP_0004664 delayed inner ear development http://purl.obolibrary.org/obo/MP_0011238 abnormal inner ear development slowed progression to structurally mature components of the labyrinth, including the semicircular canals, vestibule and cochlea http://purl.obolibrary.org/obo/MP_0004665 abnormal stapedial artery morphology http://purl.obolibrary.org/obo/MP_0011655 abnormal systemic artery morphology any structural anomaly in the small artery that passes through the ring of the stapes; while the stapedial artery is a temporary artery thought to disappear at late embryonic stage in humans, the mouse stapedial artery is complete by E13 and persists into adulthood http://purl.obolibrary.org/obo/MP_0004666 absent stapedial artery http://purl.obolibrary.org/obo/MP_0004665 abnormal stapedial artery morphology absence of the small artery that passes through the ring of the stapes http://purl.obolibrary.org/obo/MP_0004667 vertebral body hypoplasia http://purl.obolibrary.org/obo/MP_0004670 small vertebral body underdevelopment or reduced size, usually due to a reduced number of cells, of the main cylindrical portion of the vertebra ventral to the vertebral canal http://purl.obolibrary.org/obo/MP_0004668 absent vertebral body http://purl.obolibrary.org/obo/MP_0000141 abnormal vertebral body morphology absence of the main cylindrical portion of the vertebra ventral to the vertebral canal http://purl.obolibrary.org/obo/MP_0004669 enlarged vertebral body http://purl.obolibrary.org/obo/MP_0000141 abnormal vertebral body morphology increased size of the main cylindrical portion of the vertebra ventral to the vertebral canal http://purl.obolibrary.org/obo/MP_0004670 small vertebral body http://purl.obolibrary.org/obo/MP_0000141 abnormal vertebral body morphology decreased size of the main cylindrical portion of the vertebra ventral to the vertebral canal http://purl.obolibrary.org/obo/MP_0004671 long ribs http://purl.obolibrary.org/obo/MP_0000150 abnormal rib morphology increased length of the bones forming the bony wall of the chest http://purl.obolibrary.org/obo/MP_0004672 short ribs http://purl.obolibrary.org/obo/MP_0000150 abnormal rib morphology reduced length of the bones forming the bony wall of the chest http://purl.obolibrary.org/obo/MP_0004673 splayed ribs http://purl.obolibrary.org/obo/MP_0000150 abnormal rib morphology any deviation from the normal curvature of the ribs such that the ribs are turned outward http://purl.obolibrary.org/obo/MP_0004674 thin ribs http://purl.obolibrary.org/obo/MP_0000150 abnormal rib morphology a more slender appearance of the bones forming the bony wall of the chest http://purl.obolibrary.org/obo/MP_0004675 rib fractures http://purl.obolibrary.org/obo/MP_0000150 abnormal rib morphology a crack or break in the bones forming the bony wall of the chest http://purl.obolibrary.org/obo/MP_0004676 wide ribs http://purl.obolibrary.org/obo/MP_0000150 abnormal rib morphology an increase in the width of the bones forming the bony wall of the chest http://purl.obolibrary.org/obo/MP_0004677 truncated ribs http://purl.obolibrary.org/obo/MP_0000150 abnormal rib morphology ribs that terminate abruptly as if having an end or point cut off http://purl.obolibrary.org/obo/MP_0004678 split xiphoid process http://purl.obolibrary.org/obo/MP_0000159 abnormal xiphoid process morphology the appearance of an abnormal division of the caudal tip of the sternum http://purl.obolibrary.org/obo/MP_0004679 xiphoid process foramen http://purl.obolibrary.org/obo/MP_0000159 abnormal xiphoid process morphology the appearance of a hole or holes in the caudal tip of the sternum http://purl.obolibrary.org/obo/MP_0004680 small xiphoid process http://purl.obolibrary.org/obo/MP_0000159 abnormal xiphoid process morphology reduced size of the caudal tip of the sternum http://purl.obolibrary.org/obo/MP_0004681 intervertebral disk hypoplasia http://purl.obolibrary.org/obo/MP_0004682 small intervertebral disk underdevelopment or reduced size, usually due to a reduced number of cells, of the cartilaginous and gelatinous structure found between vertebrae http://purl.obolibrary.org/obo/MP_0004682 small intervertebral disk http://purl.obolibrary.org/obo/MP_0004173 abnormal intervertebral disk morphology reduced size of the cartilaginous and gelatinous structure found between vertebrae http://purl.obolibrary.org/obo/MP_0004683 absent intervertebral disk http://purl.obolibrary.org/obo/MP_0004173 abnormal intervertebral disk morphology absence of the cartilaginous and gelatinous structure found between vertebrae http://purl.obolibrary.org/obo/MP_0004684 intervertebral disk degeneration http://purl.obolibrary.org/obo/MP_0004173 abnormal intervertebral disk morphology retrogressive pathological change of the cartilaginous and gelatinous structure found between vertebrae http://purl.obolibrary.org/obo/MP_0004685 calcified intervertebral disk http://purl.obolibrary.org/obo/MP_0004173 abnormal intervertebral disk morphology process in which the cartilaginous and gelatinous structure found between vertebrae becomes hardened due to deposits of calcium salts http://purl.obolibrary.org/obo/MP_0004687 split vertebrae http://purl.obolibrary.org/obo/MP_0000137 abnormal vertebrae morphology any vertebrae or vertebral section that is cleft into two parts http://purl.obolibrary.org/obo/MP_0004688 absent ilium http://purl.obolibrary.org/obo/MP_0005354 abnormal ilium morphology absence of the broad, flaring portion of the hip bone, which is distinct at birth, but later fuses with the ischium and the pubis http://purl.obolibrary.org/obo/MP_0004689 small ischium http://purl.obolibrary.org/obo/MP_0004507 abnormal ischium morphology reduced size of the lowest of the three major bones that constitute each half of the pelvis, distinct at birth but later becoming fused with the ilium and pubis http://purl.obolibrary.org/obo/MP_0004690 ischium hypoplasia http://purl.obolibrary.org/obo/MP_0004689 small ischium underdevelopment or reduced size, usually due to a reduced number of cells, of the lowest of the three major bones that constitute each half of the pelvis, distinct at birth but later becoming fused with the ilium and pubis http://purl.obolibrary.org/obo/MP_0004691 absent pubis http://purl.obolibrary.org/obo/MP_0004506 abnormal pubis morphology absence of the forward portion of either of the hipbones, at the juncture forming the front arch of the pelvis http://purl.obolibrary.org/obo/MP_0004692 small pubis http://purl.obolibrary.org/obo/MP_0004506 abnormal pubis morphology reduced size of the forward portion of either of the hipbones, at the juncture forming the front arch of the pelvis http://purl.obolibrary.org/obo/MP_0004693 pubis hypoplasia http://purl.obolibrary.org/obo/MP_0004692 small pubis underdevelopment or reduced size, usually due to a reduced number of cells, of the forward portion of either of the hipbones, at the juncture forming the front arch of the pelvis http://purl.obolibrary.org/obo/MP_0004694 absent patella http://purl.obolibrary.org/obo/MP_0005353 abnormal patella morphology absence of the large sesamoid bone that covers the anterior surface of the knee http://purl.obolibrary.org/obo/MP_0004696 abnormal thyroid follicle morphology http://purl.obolibrary.org/obo/MP_0000681 abnormal thyroid gland morphology any structural anomaly of the small spherical vesicular components of the thyroid gland that are lined with epithelium and contain a colloid substance that both serves as a reservoir of materials for thyroid hormone production and stores thyroid hormones http://purl.obolibrary.org/obo/MP_0004697 abnormal thyroid follicular cell morphology http://purl.obolibrary.org/obo/MP_0004696 abnormal thyroid follicle morphology any structural anomaly of the thyroxine-producing follicular cells derived from the thyroid diverticulum which evaginates from the endodermal epithelium of the embryonic pharyngeal floor http://purl.obolibrary.org/obo/MP_0004698 abnormal thyroid parafollicular C-cell morphology http://purl.obolibrary.org/obo/MP_0000681 abnormal thyroid gland morphology any structural anomaly of the calcitonin-producing C-cells which are derived from the ultimobranchial body (a sac-like structure emanating from the neural crest) and constitute the minor component of the thyroid gland http://purl.obolibrary.org/obo/MP_0004699 unilateral deafness http://purl.obolibrary.org/obo/MP_0006325 impaired hearing bilateral asymmetry in auditory function whereby one of the two ears displays auditory thresholds indicative of intact hearing while the other ear displays thresholds reflecting auditory dysfunction http://purl.obolibrary.org/obo/MP_0004700 abnormal circulating insulin-like growth factor I level http://purl.obolibrary.org/obo/MP_0008831 abnormal insulin-like growth factor I level anomalous blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities http://purl.obolibrary.org/obo/MP_0004701 decreased circulating insulin-like growth factor I level http://purl.obolibrary.org/obo/MP_0004700 abnormal circulating insulin-like growth factor I level reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities http://purl.obolibrary.org/obo/MP_0004702 increased circulating insulin-like growth factor I level http://purl.obolibrary.org/obo/MP_0004700 abnormal circulating insulin-like growth factor I level increased blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities http://purl.obolibrary.org/obo/MP_0004704 short vertebral column http://purl.obolibrary.org/obo/MP_0004703 abnormal vertebral column morphology decreased rostral-caudal length of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord http://purl.obolibrary.org/obo/MP_0004705 elongated vertebral body http://purl.obolibrary.org/obo/MP_0000141 abnormal vertebral body morphology increased length of the main cylindrical portion of the vertebra ventral to the vertebral canal http://purl.obolibrary.org/obo/MP_0004706 short vertebral body http://purl.obolibrary.org/obo/MP_0004670 small vertebral body reduced length of the main cylindrical portion of the vertebra ventral to the vertebral canal http://purl.obolibrary.org/obo/MP_0004707 enlarged lumbar vertebrae http://purl.obolibrary.org/obo/MP_0003049 abnormal lumbar vertebrae morphology increased size of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae http://purl.obolibrary.org/obo/MP_0004708 short lumbar vertebrae http://purl.obolibrary.org/obo/MP_0003049 abnormal lumbar vertebrae morphology reduced length of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae http://purl.obolibrary.org/obo/MP_0004709 cervical vertebrae degeneration http://purl.obolibrary.org/obo/MP_0003048 abnormal cervical vertebrae morphology retrogressive pathologic change of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae and caudal to the skull http://purl.obolibrary.org/obo/MP_0004710 small notochord http://purl.obolibrary.org/obo/MP_0002825 abnormal notochord morphology reduced size of the axial fibrocellular cord in embryos around which develops the vertebral primordia http://purl.obolibrary.org/obo/MP_0004711 persistence of notochord tissue http://purl.obolibrary.org/obo/MP_0002825 abnormal notochord morphology failure of notochord tissue to differentiate into the vertebral primordia during development resulting in the presence of notochord tissue at later stages than it is normally seen http://purl.obolibrary.org/obo/MP_0004712 notochord degeneration http://purl.obolibrary.org/obo/MP_0002825 abnormal notochord morphology retrogressive pathologic change of the axial fibrocellular cord in embryos around which develops the vertebral primordia (prior to normal differentiation of this tissue into the vertebral column tissues) http://purl.obolibrary.org/obo/MP_0004713 split notochord http://purl.obolibrary.org/obo/MP_0002825 abnormal notochord morphology the appearance of an abnormal division in the axial fibrocellular cord in embryos around which develops the vertebral primordia http://purl.obolibrary.org/obo/MP_0004714 truncated notochord http://purl.obolibrary.org/obo/MP_0002825 abnormal notochord morphology notochord morphology that terminates abruptly as if having an end or point cut off http://purl.obolibrary.org/obo/MP_0004715 absent vestibulocochlear nerve http://purl.obolibrary.org/obo/MP_0001072 abnormal vestibulocochlear nerve morphology absence of the composite sensory nerve innervating the receptor cells of the membranous labyrinth http://purl.obolibrary.org/obo/MP_0004716 abnormal cochlear nerve morphology http://purl.obolibrary.org/obo/MP_0001072 abnormal vestibulocochlear nerve morphology any structural anomaly in the part of the vestibulocochlear nerve [CN VIII] peripheral to the cochlear root; composed of the central nerve processes of the bipolar neurons of the spiral ganglion, which have their peripheral processes on the four rows of neuroepithelial cells (hair cells) of the spiral organ http://purl.obolibrary.org/obo/MP_0004717 absent cochlear nerve http://purl.obolibrary.org/obo/MP_0004716 abnormal cochlear nerve morphology absence of the part of the vestibulocochlear nerve [CN VIII] that is peripheral to the cochlear root http://purl.obolibrary.org/obo/MP_0004718 abnormal vestibular nerve morphology http://purl.obolibrary.org/obo/MP_0001072 abnormal vestibulocochlear nerve morphology any structural anomaly in the part of the vestibulocochlear nerve [CN VIII] peripheral to the vestibular root; it is composed of the central processes of bipolar neurons that have the terminals of their peripheral processes on the hair cells in the ampullae of the semicircular ducts and the maculae of the saccule and utricle, and cell bodies of the vestibular ganglion http://purl.obolibrary.org/obo/MP_0004719 absent vestibular nerve http://purl.obolibrary.org/obo/MP_0004718 abnormal vestibular nerve morphology absence of the part of the vestibulocochlear nerve [CN VIII] that is peripheral to the vestibular root http://purl.obolibrary.org/obo/MP_0004721 abnormal platelet dense granule morphology http://purl.obolibrary.org/obo/MP_0004720 abnormal platelet morphology any structural anomaly of the electron-dense bodies occurring in blood platelets that store and secrete adenosine nucleotides and serotonin http://purl.obolibrary.org/obo/MP_0004722 abnormal platelet dense granule number http://purl.obolibrary.org/obo/MP_0004721 abnormal platelet dense granule morphology altered number of the electron-dense bodies occurring in blood platelets that store and secrete adenosine nucleotides and serotonin http://purl.obolibrary.org/obo/MP_0004723 abnormal platelet serotonin level http://purl.obolibrary.org/obo/MP_0005322 abnormal serotonin level anomaly in the amount in platelets of serotonin, a biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity http://purl.obolibrary.org/obo/MP_0004724 increased platelet serotonin level http://purl.obolibrary.org/obo/MP_0010069 increased serotonin level greater than normal amount in platelets of serotonin, a biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity http://purl.obolibrary.org/obo/MP_0004725 decreased platelet serotonin level http://purl.obolibrary.org/obo/MP_0010070 decreased serotonin level reduced amount in platelets of serotonin, a biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity http://purl.obolibrary.org/obo/MP_0004726 abnormal nasal capsule morphology http://purl.obolibrary.org/obo/MP_0003935 abnormal craniofacial development any structural anomaly in the cartilage around the developing nasal cavity of the embryo http://purl.obolibrary.org/obo/MP_0004727 absent epididymis http://purl.obolibrary.org/obo/MP_0002631 abnormal epididymis morphology absence of the elongated structure connected to the posterior surface of the testis, consisting of the head, body, and tail, which turns sharply on itself to become the ductus deferens (vas deferens) http://purl.obolibrary.org/obo/MP_0004728 abnormal efferent ductules of testis morphology http://purl.obolibrary.org/obo/MP_0001146 abnormal testis morphology any structural anomaly in the small seminal ducts that lead from the testis to the head of the epididymis http://purl.obolibrary.org/obo/MP_0004729 absent efferent ductules of testis http://purl.obolibrary.org/obo/MP_0004728 abnormal efferent ductules of testis morphology absence of the small seminal ducts that lead from the testis to the head of the epididymis http://purl.obolibrary.org/obo/MP_0004730 abnormal circulating gastrin level http://purl.obolibrary.org/obo/MP_0005418 abnormal circulating hormone level anomalous concentration in the blood of polypeptide hormones secreted by the pyloric-antral mucous lining of the stomach that induces the secretion of gastric juice by the parietal cells of the gastric glands; they also occur in the central nervous system where they are presumed to be neurotransmitters http://purl.obolibrary.org/obo/MP_0004731 increased circulating gastrin level http://purl.obolibrary.org/obo/MP_0004730 abnormal circulating gastrin level greater concentration in the blood of polypeptide hormones secreted by the pyloric-antral mucous lining of the stomach that induces the secretion of gastric juice by the parietal cells of the gastric glands; they also occur in the central nervous system where they are presumed to be neurotransmitters http://purl.obolibrary.org/obo/MP_0004732 decreased circulating gastrin level http://purl.obolibrary.org/obo/MP_0004730 abnormal circulating gastrin level reduced concentration in the blood of polypeptide hormones secreted by the pyloric-antral mucous lining of the stomach that induces the secretion of gastric juice by the parietal cells of the gastric glands; they also occur in the central nervous system where they are presumed to be neurotransmitters http://purl.obolibrary.org/obo/MP_0004733 abnormal thoracic cavity morphology http://purl.obolibrary.org/obo/MP_0004134 abnormal chest morphology any structural anomaly of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway http://purl.obolibrary.org/obo/MP_0004734 small thoracic cavity http://purl.obolibrary.org/obo/MP_0004733 abnormal thoracic cavity morphology reduced size of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway http://purl.obolibrary.org/obo/MP_0004735 enlarged thoracic cavity http://purl.obolibrary.org/obo/MP_0004733 abnormal thoracic cavity morphology increased size of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway http://purl.obolibrary.org/obo/MP_0004736 abnormal distortion product otoacoustic emission http://purl.obolibrary.org/obo/MP_0006336 abnormal otoacoustic response any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs http://purl.obolibrary.org/obo/MP_0004737 absent distortion product otoacoustic emissions http://purl.obolibrary.org/obo/MP_0004736 abnormal distortion product otoacoustic emission failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion http://purl.obolibrary.org/obo/MP_0004738 abnormal auditory brainstem response http://purl.obolibrary.org/obo/MP_0006335 abnormal hearing electrophysiology anomaly in the electrical activity generated in the ascending auditory system in response to short tone bursts; may be used to evaluate sensorineural hearing function; measurements may include the amplitude (the number of neurons firing), latency (the speed of transmission), interpeak latency (the time between peaks), interaural latency (the difference in wave V latency between ears) and threshold http://purl.obolibrary.org/obo/MP_0004739 conductive hearing loss http://purl.obolibrary.org/obo/MP_0006326 conductive hearing impairment progressive hearing loss due to lesions in the external auditory canal or middle ear http://purl.obolibrary.org/obo/MP_0004740 sensorineural hearing loss http://purl.obolibrary.org/obo/MP_0006329 sensorineural hearing impairment a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear http://purl.obolibrary.org/obo/MP_0004741 mixed hearing loss http://purl.obolibrary.org/obo/MP_0006327 mixed hearing impairment progressive reduction in the ability to hear resulting from a combination of conductive and sensorineural hearing loss http://purl.obolibrary.org/obo/MP_0004742 abnormal vestibular system physiology http://purl.obolibrary.org/obo/MP_0003878 abnormal ear physiology any functional anomaly of the sensory system responsible for the sense of head position and movement of the body through space; such anomalies may result in impaired balance, dizziness, poor regulation of postural muscle tone and inability to detect quick movements of the head http://purl.obolibrary.org/obo/MP_0004743 abnormal vestibular evoked myogenic potential http://purl.obolibrary.org/obo/MP_0004742 abnormal vestibular system physiology anomaly in the biphasic response elicited by loud clicks or tone bursts recorded from the tonically contracted sternocleidomastoid muscle; normally, acoustic stimulation of the saccule gives rise to a vestibulocollic reflex, the output of which can be measured in the neck as inhibition of activity in the ipsilateral sternocleidomastoid muscle; VEMP testing provides diagnostic information about saccular and/or inferior vestibular nerve function (assessment of balance disorders) http://purl.obolibrary.org/obo/MP_0004744 reduced vestibular evoked myogenic potential http://purl.obolibrary.org/obo/MP_0004743 abnormal vestibular evoked myogenic potential reduction of the biphasic response that is elicited by loud clicks or tone bursts and recorded from the tonically contracted sternocleidomastoid muscle http://purl.obolibrary.org/obo/MP_0004745 absent vestibular evoked myogenic potential http://purl.obolibrary.org/obo/MP_0004743 abnormal vestibular evoked myogenic potential absence of the biphasic response that is elicited by loud clicks or tone bursts and recorded from the tonically contracted sternocleidomastoid muscle http://purl.obolibrary.org/obo/MP_0004746 abnormal cochlear IHC afferent innervation pattern http://purl.obolibrary.org/obo/MP_0004393 abnormal cochlear inner hair cell morphology any changes in the placement, morphology or number of afferent terminals and/or their synapses in the cochlear IHC region http://purl.obolibrary.org/obo/MP_0004747 abnormal cochlear OHC afferent innervation pattern http://purl.obolibrary.org/obo/MP_0004399 abnormal cochlear outer hair cell morphology any changes in the morphology, placement or number of afferent terminals and/or their synapses in the cochlear OHC region http://purl.obolibrary.org/obo/MP_0004748 increased susceptibility to age-related hearing loss http://purl.obolibrary.org/obo/MP_0006334 abnormal susceptibility to hearing loss greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary http://purl.obolibrary.org/obo/MP_0004749 nonsyndromic hearing loss http://purl.obolibrary.org/obo/MP_0006328 nonsyndromic hearing impairment a form of progressive hearing loss that is not associated with visible abnormalities of the external ear or other signs and symptoms; the vast majority of hereditary hearing loss is nonsyndromic and can be associated with abnormalities of the middle ear and/or inner ear http://purl.obolibrary.org/obo/MP_0004750 syndromic hearing loss http://purl.obolibrary.org/obo/MP_0006330 syndromic hearing impairment a form of progressive hearing loss that is usually associated with malformations of the external ear and other inherited signs and symptoms http://purl.obolibrary.org/obo/MP_0004751 increased length of allograft survival http://purl.obolibrary.org/obo/MP_0005671 abnormal response to transplant compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive http://purl.obolibrary.org/obo/MP_0004752 decreased length of allograft survival http://purl.obolibrary.org/obo/MP_0005671 abnormal response to transplant compared to controls, a reduced length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive http://purl.obolibrary.org/obo/MP_0004753 abnormal miniature excitatory postsynaptic currents http://purl.obolibrary.org/obo/MP_0002206 abnormal CNS synaptic transmission defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse http://purl.obolibrary.org/obo/MP_0004754 abnormal kidney collecting duct morphology http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology any structural anomaly of the kidney ducts lined by simple cuboidal epithelium that collect urine from the distal convoluted tubules, merge and become larger as they descend from the renal cortex into the medulla, and respond to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance; each cortical collecting duct joints with other ducts to make a medullary connecting duct, which eventually drains into a papillary duct, emptying urine into the renal pelvis for drainage into the ureter http://purl.obolibrary.org/obo/MP_0004755 abnormal loop of Henle morphology http://purl.obolibrary.org/obo/MP_0002703 abnormal renal tubule morphology any structural anomaly of the section of the renal tubule in the kidney medulla with a hairpin bend; consists of a descending limb and an ascending limb, and is situated between the proximal convoluted tubule to the distal convoluted tubule; it functions to reabsorb water and ions from the urine http://purl.obolibrary.org/obo/MP_0004756 abnormal proximal convoluted tubule morphology http://purl.obolibrary.org/obo/MP_0002703 abnormal renal tubule morphology any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes; the most distinctive characteristic of the proximal tubule is its brush border (or striated border), not found in the distal convoluted tubule http://purl.obolibrary.org/obo/MP_0004757 abnormal distal convoluted tubule morphology http://purl.obolibrary.org/obo/MP_0002703 abnormal renal tubule morphology any structural anomaly of the convoluted portion of the duct system of the nephron between the ascending portion of the loop of Henle and the collecting duct system in the kidney cortex; it is partly responsible for the regulation of potassium, sodium, calcium, and pH through the endocrine system http://purl.obolibrary.org/obo/MP_0004758 absent strial marginal cells http://purl.obolibrary.org/obo/MP_0004366 abnormal strial marginal cell morphology absence or loss of the polarized columnar cells of epithelial origin which cover the lateral surface of the cochlear duct, secrete potassium ions and form a continuous sheet in contact with the endolymph http://purl.obolibrary.org/obo/MP_0004759 decreased mitotic index http://purl.obolibrary.org/obo/MP_0004046 abnormal mitosis decreased number of cells in G2/M phase http://purl.obolibrary.org/obo/MP_0004760 increased mitotic index http://purl.obolibrary.org/obo/MP_0004046 abnormal mitosis increased number of cells in G2/M phase http://purl.obolibrary.org/obo/MP_0004761 increased susceptibility to induced pancreatitis http://purl.obolibrary.org/obo/MP_0001869 pancreas inflammation more likely than normal to develop an inflammatory response, or an increased inflammatory response in the pancreatic tissue after experimental manipulation http://purl.obolibrary.org/obo/MP_0004762 increased anti-double stranded DNA antibody level http://purl.obolibrary.org/obo/MP_0004794 increased anti-nuclear antigen antibody level increase in the level of antibodies that recognize double stranded DNA http://purl.obolibrary.org/obo/MP_0004766 decreased susceptibility to age-related hearing loss http://purl.obolibrary.org/obo/MP_0006334 abnormal susceptibility to hearing loss less than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary http://purl.obolibrary.org/obo/MP_0004767 increased cochlear nerve compound action potential http://purl.obolibrary.org/obo/MP_0004415 abnormal cochlear nerve compound action potential greater combined potentials resulting from activation of the auditory division of the eighth cranial nerve http://purl.obolibrary.org/obo/MP_0004768 abnormal axonal transport http://purl.obolibrary.org/obo/MP_0004811 abnormal neuron physiology any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons http://purl.obolibrary.org/obo/MP_0004769 abnormal synaptic vesicle morphology http://purl.obolibrary.org/obo/MP_0009538 abnormal synapse morphology any structural anomaly of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents http://purl.obolibrary.org/obo/MP_0004770 abnormal synaptic vesicle recycling http://purl.obolibrary.org/obo/MP_0004811 abnormal neuron physiology any functional anomaly in the process of the fusion of a subpopulation of synaptic vesicles with the cell membrane at the active zone, the subsequent endocytosis back from the plasma membrane, the refilling of these vesicles with neurotransmitters, and trafficking back to the active zone pool of vesicles http://purl.obolibrary.org/obo/MP_0004771 increased anti-single stranded DNA antibody level http://purl.obolibrary.org/obo/MP_0004794 increased anti-nuclear antigen antibody level increase in the level of antibodies that recognize single stranded DNA http://purl.obolibrary.org/obo/MP_0004772 abnormal bile secretion http://purl.obolibrary.org/obo/MP_0005085 abnormal gallbladder physiology any anomaly in the quantity or rate of bile secreted through the bile ducts in a given length of time http://purl.obolibrary.org/obo/MP_0004773 abnormal bile composition http://purl.obolibrary.org/obo/MP_0005085 abnormal gallbladder physiology any alteration in the chemical make up of the greenish-yellow fluid secreted by the liver; normally contains bile acids and salts such as sodium glycocholate and sodium taurocholate as well as cholesterol, biliverdin and bilirubin, mucus, fat, lecithin, and cells and cellular debris http://purl.obolibrary.org/obo/MP_0004774 abnormal bile salt level http://purl.obolibrary.org/obo/MP_0005365 abnormal bile salt homeostasis anomalous concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary system as bile salts; these play an important role in the digestion and absorption of fats http://purl.obolibrary.org/obo/MP_0004775 abnormal vestibular dark cell morphology http://purl.obolibrary.org/obo/MP_0000034 abnormal inner ear vestibule morphology any structural anomaly in the nonsensory epithelial cells located above the vestibular melanocytes and adjacent to the sensory structures in the utricle and in the ampullae at the ends of each of the semicircular canals; these cells provide and maintain the high potassium ionic environment within the vestibular labyrinth and are therefore homologous to the marginal cells of the stria vascularis; they are joined to each other by tight junctions and provide a barrier between endolymph and perilymph http://purl.obolibrary.org/obo/MP_0004776 vestibular dark cell degeneration http://purl.obolibrary.org/obo/MP_0004775 abnormal vestibular dark cell morphology degeneration or loss of the nonsensory epithelial cells that lie adjacent to the sensory structures in the utricle and in the ampullae at the ends of each of the semicircular canals http://purl.obolibrary.org/obo/MP_0004777 abnormal phospholipid level http://purl.obolibrary.org/obo/MP_0001547 abnormal lipid level anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group http://purl.obolibrary.org/obo/MP_0004778 increased macrophage derived foam cell number http://purl.obolibrary.org/obo/MP_0009841 foam cell reticulosis greater than normal number of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions http://purl.obolibrary.org/obo/MP_0004780 abnormal surfactant secretion http://purl.obolibrary.org/obo/MP_0004782 abnormal surfactant physiology anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli http://purl.obolibrary.org/obo/MP_0004781 abnormal surfactant composition http://purl.obolibrary.org/obo/MP_0004782 abnormal surfactant physiology anomaly in the chemical constituents of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli http://purl.obolibrary.org/obo/MP_0004782 abnormal surfactant physiology http://purl.obolibrary.org/obo/MP_0002133 abnormal respiratory system physiology anomaly in the production, composition or function of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli http://purl.obolibrary.org/obo/MP_0004783 abnormal cardinal vein morphology http://purl.obolibrary.org/obo/MP_0003411 abnormal vein development any structural anomaly of any of the four veins in the developing vertebrate embryo which run along each side of the vertebral column http://purl.obolibrary.org/obo/MP_0004784 abnormal anterior cardinal vein morphology http://purl.obolibrary.org/obo/MP_0004783 abnormal cardinal vein morphology any structural anomaly of the two paired veins draining the cephalic part of the body http://purl.obolibrary.org/obo/MP_0004785 abnormal posterior cardinal vein morphology http://purl.obolibrary.org/obo/MP_0004783 abnormal cardinal vein morphology any structural anomaly of the two paired veins draining the caudal part of the body http://purl.obolibrary.org/obo/MP_0004786 abnormal common cardinal vein morphology http://purl.obolibrary.org/obo/MP_0004783 abnormal cardinal vein morphology any structural anomaly of the anastomosis of the anterior and posterior cardinal veins that returns blood to the developing heart http://purl.obolibrary.org/obo/MP_0004788 abnormal auditory cortex tonotopy http://purl.obolibrary.org/obo/MP_0004631 abnormal auditory cortex morphology any abnormality in the spatial arrangement of structures that subserve various frequencies in the region of the cerebral cortex that receives the auditory radiation from the medial geniculate body http://purl.obolibrary.org/obo/MP_0004789 increased bile salt level http://purl.obolibrary.org/obo/MP_0004774 abnormal bile salt level increased concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary system as bile salts; these play an important role in the digestion and absorption of fats http://purl.obolibrary.org/obo/MP_0004790 absent upper incisors http://purl.obolibrary.org/obo/MP_0000125 absent incisors absence of the upper pair of long teeth that are the most anterior and prominent in the jaw http://purl.obolibrary.org/obo/MP_0004791 absent lower incisors http://purl.obolibrary.org/obo/MP_0000125 absent incisors missing the lower pair of long teeth that are the most anterior and prominent in the jaw http://purl.obolibrary.org/obo/MP_0004792 abnormal synaptic vesicle number http://purl.obolibrary.org/obo/MP_0004769 abnormal synaptic vesicle morphology anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents http://purl.obolibrary.org/obo/MP_0004793 abnormal synaptic vesicle clustering http://purl.obolibrary.org/obo/MP_0004811 abnormal neuron physiology any functional anomaly in the process of accumulation of synaptic vesicles at the active zone of presynaptic membranes http://purl.obolibrary.org/obo/MP_0004794 increased anti-nuclear antigen antibody level http://purl.obolibrary.org/obo/MP_0003725 increased autoantibody level elevated level of antibodies to nuclear antigens present in the sera http://purl.obolibrary.org/obo/MP_0004795 decreased anti-nuclear antigen antibody level http://purl.obolibrary.org/obo/MP_0003726 decreased autoantibody level reduced level of antibodies to nuclear antigens present in the sera http://purl.obolibrary.org/obo/MP_0004796 increased anti-histone antibody level http://purl.obolibrary.org/obo/MP_0004794 increased anti-nuclear antigen antibody level elevated level of antibodies to histones present in the sera http://purl.obolibrary.org/obo/MP_0004797 increased anti-erythrocyte antigen antibody level http://purl.obolibrary.org/obo/MP_0003725 increased autoantibody level elevated level of antibodies to erythrocyte antigen present in the sera http://purl.obolibrary.org/obo/MP_0004798 decreased anti-double stranded DNA antibody level http://purl.obolibrary.org/obo/MP_0004795 decreased anti-nuclear antigen antibody level reduced level of antibodies to double stranded DNA present in the sera http://purl.obolibrary.org/obo/MP_0004799 increased susceptibility to experimental autoimmune encephalomyelitis http://purl.obolibrary.org/obo/MP_0005350 increased susceptibility to autoimmune disorder greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG) http://purl.obolibrary.org/obo/MP_0004800 decreased susceptibility to experimental autoimmune encephalomyelitis http://purl.obolibrary.org/obo/MP_0005351 decreased susceptibility to autoimmune disorder reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG) http://purl.obolibrary.org/obo/MP_0004801 increased susceptibility to systemic lupus erythematosus http://purl.obolibrary.org/obo/MP_0005350 increased susceptibility to autoimmune disorder greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs http://purl.obolibrary.org/obo/MP_0004802 decreased susceptibility to systemic lupus erythematosus http://purl.obolibrary.org/obo/MP_0005351 decreased susceptibility to autoimmune disorder reduced likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs http://purl.obolibrary.org/obo/MP_0004803 increased susceptibility to autoimmune diabetes http://purl.obolibrary.org/obo/MP_0005350 increased susceptibility to autoimmune disorder greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas http://purl.obolibrary.org/obo/MP_0004804 decreased susceptibility to autoimmune diabetes http://purl.obolibrary.org/obo/MP_0005351 decreased susceptibility to autoimmune disorder reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas http://purl.obolibrary.org/obo/MP_0004805 absent oocytes http://purl.obolibrary.org/obo/MP_0005431 decreased oocyte number absence of mature germ cells in the female http://purl.obolibrary.org/obo/MP_0004807 abnormal paired-pulse inhibition http://purl.obolibrary.org/obo/MP_0003635 abnormal synaptic transmission defects in the suppressive response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of inhibition of neurotransmitter release at the second stimulus http://purl.obolibrary.org/obo/MP_0004808 abnormal hematopoietic stem cell morphology http://purl.obolibrary.org/obo/MP_0002396 abnormal hematopoietic system morphology/development any structural anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow, yolk sac and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages http://purl.obolibrary.org/obo/MP_0004809 increased hematopoietic stem cell number http://purl.obolibrary.org/obo/MP_0004808 abnormal hematopoietic stem cell morphology greater cell count of the multipotent, self-renewing stem cells found in the bone marrow, yolk sac and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages http://purl.obolibrary.org/obo/MP_0004810 decreased hematopoietic stem cell number http://purl.obolibrary.org/obo/MP_0004808 abnormal hematopoietic stem cell morphology reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow, yolk sac and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages http://purl.obolibrary.org/obo/MP_0004812 abnormal linear vestibular evoked potential http://purl.obolibrary.org/obo/MP_0004742 abnormal vestibular system physiology anomaly in the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal's head); normally, this response is measured by electrophysiological activity of the peripheral vestibular nerve; this assesses the function of the gravity receptor system including the utricles and saccules of the inner ear http://purl.obolibrary.org/obo/MP_0004813 absent linear vestibular evoked potential http://purl.obolibrary.org/obo/MP_0004812 abnormal linear vestibular evoked potential absence of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal's head) http://purl.obolibrary.org/obo/MP_0004814 reduced linear vestibular evoked potential http://purl.obolibrary.org/obo/MP_0004812 abnormal linear vestibular evoked potential reduction of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal's head) http://purl.obolibrary.org/obo/MP_0004815 abnormal somatic hypermutation frequency http://purl.obolibrary.org/obo/MP_0002420 abnormal adaptive immunity any anomaly in the high frequency of programmed mutation that occurs in the gene segments encoding the variable regions of antibodies during the differentiation of individual B lymphocytes into antibody producing plasma cells http://purl.obolibrary.org/obo/MP_0004816 abnormal class switch recombination http://purl.obolibrary.org/obo/MP_0002459 abnormal B cell physiology anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions http://purl.obolibrary.org/obo/MP_0004817 abnormal skeletal muscle mass http://purl.obolibrary.org/obo/MP_0000759 abnormal skeletal muscle morphology anomaly in the physical bulk, or total amount of matter contained within skeletal muscle http://purl.obolibrary.org/obo/MP_0004819 decreased skeletal muscle mass http://purl.obolibrary.org/obo/MP_0004817 abnormal skeletal muscle mass reduction in the physical bulk, or total amount of matter contained within skeletal muscle http://purl.obolibrary.org/obo/MP_0004820 abnormal urine potassium level http://purl.obolibrary.org/obo/MP_0011978 abnormal potassium ion homeostasis any change in the amount of potassium in the urine http://purl.obolibrary.org/obo/MP_0004821 increased susceptibility to experimental autoimmune uveoretinitis http://purl.obolibrary.org/obo/MP_0005350 increased susceptibility to autoimmune disorder greater likelihood that an organism will develop disease symptoms similar to human sight-threatening inflammatory eye diseases upon induction by peripheral immunization with one of several uveitogenic retinal proteins (or with peptides derived from them), or by the adoptive transfer of lymphocytes specific to these antigens http://purl.obolibrary.org/obo/MP_0004822 decreased susceptibility to experimental autoimmune uveoretinitis http://purl.obolibrary.org/obo/MP_0005351 decreased susceptibility to autoimmune disorder reduced likelihood that an organism will develop disease symptoms similar to human sight-threatening inflammatory eye diseases upon induction by peripheral immunization with one of several uveitogenic retinal proteins (or with peptides derived from them), or by the adoptive transfer of lymphocytes specific to these antigens http://purl.obolibrary.org/obo/MP_0004823 increased susceptibility to experimental autoimmune myasthenia gravis http://purl.obolibrary.org/obo/MP_0005350 increased susceptibility to autoimmune disorder greater likelihood that an organism will develop disease symptoms similar to human myasthenia gravis upon induction with antigens to acetylcholine receptor subunits http://purl.obolibrary.org/obo/MP_0004824 decreased susceptibility to experimental autoimmune myasthenia gravis http://purl.obolibrary.org/obo/MP_0005351 decreased susceptibility to autoimmune disorder reduced likelihood that an organism will develop disease symptoms similar to human myasthenia gravis upon induction with antigens to acetylcholine receptor subunits http://purl.obolibrary.org/obo/MP_0004825 increased susceptibility to experimental autoimmune thyroiditis http://purl.obolibrary.org/obo/MP_0005350 increased susceptibility to autoimmune disorder greater likelihood that an organism will develop disease symptoms similar to human autoimmune thyroiditis upon induction with antigens to thyroglobulin http://purl.obolibrary.org/obo/MP_0004826 decreased susceptibility to experimental autoimmune thyroiditis http://purl.obolibrary.org/obo/MP_0005351 decreased susceptibility to autoimmune disorder reduced likelihood that an organism will develop disease symptoms similar to human autoimmune thyroiditis upon induction with antigens to thyroglobulin http://purl.obolibrary.org/obo/MP_0004827 increased susceptibility to autoimmune hemolytic anemia http://purl.obolibrary.org/obo/MP_0005350 increased susceptibility to autoimmune disorder greater likelihood that an organism will develop an abnormality of the immune system that destroys red blood cells (hemolysis) prematurely http://purl.obolibrary.org/obo/MP_0004828 decreased susceptibility to autoimmune hemolytic anemia http://purl.obolibrary.org/obo/MP_0005351 decreased susceptibility to autoimmune disorder reduced likelihood that an organism will develop an abnormality of the immune system that destroys red blood cells (hemolysis) prematurely http://purl.obolibrary.org/obo/MP_0004829 increased anti-chromatin antibody level http://purl.obolibrary.org/obo/MP_0004794 increased anti-nuclear antigen antibody level increase in the level of antibodies that recognize chromatin http://purl.obolibrary.org/obo/MP_0004830 short incisors http://purl.obolibrary.org/obo/MP_0005358 abnormal incisor morphology reduced length of the set of long teeth that are the most anterior and prominent in the jaw http://purl.obolibrary.org/obo/MP_0004831 long incisors http://purl.obolibrary.org/obo/MP_0005358 abnormal incisor morphology increased length of the set of long teeth that are the most anterior and prominent in the jaw http://purl.obolibrary.org/obo/MP_0004833 ovary atrophy http://purl.obolibrary.org/obo/MP_0001127 small ovary acquired diminution of the size of the ovaries associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0004834 ovary hemorrhage http://purl.obolibrary.org/obo/MP_0004245 genital hemorrhage presence of bleeding in the ovary http://purl.obolibrary.org/obo/MP_0004835 abnormal miniature endplate potential http://purl.obolibrary.org/obo/MP_0002913 abnormal PNS synaptic transmission defect in the size or duration of spontaneous currents detected in PNS postsynaptic cells that occur in the absence of an excitatory impulse http://purl.obolibrary.org/obo/MP_0004836 abnormal synaptic acetylcholine release http://purl.obolibrary.org/obo/MP_0005445 abnormal neurotransmitter secretion aberrant release into synapses of the excitatory neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system http://purl.obolibrary.org/obo/MP_0004837 abnormal neural fold formation http://purl.obolibrary.org/obo/MP_0011256 abnormal neural fold morphology any anomaly in the process by which the edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove http://purl.obolibrary.org/obo/MP_0004838 abnormal neural fold elevation formation http://purl.obolibrary.org/obo/MP_0004837 abnormal neural fold formation any anomaly in the process by which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm http://purl.obolibrary.org/obo/MP_0004839 bile duct hyperplasia http://purl.obolibrary.org/obo/MP_0002928 abnormal bile duct morphology overdevelopment or increased size of the bile ducts, usually due to an increase in the number of cells http://purl.obolibrary.org/obo/MP_0004840 increased Deiters cell number http://purl.obolibrary.org/obo/MP_0004302 abnormal Deiters cell morphology increased number of the supporting cells of the spiral organ which are attached to the basement membrane and receive the hair cells between their free extremities http://purl.obolibrary.org/obo/MP_0004841 abnormal small intestine crypts of Lieberkuhn morphology http://purl.obolibrary.org/obo/MP_0000496 abnormal small intestine morphology any structural anomaly of the parallel, tubular, epithelial pits (crypts) with openings at the bases of the small intestinal villi; their thin walls are formed by columnar epithelial cells: mostly undifferentiated stem and intermediate cells and an increasing number of mucus-secreting goblet cells as the small intestine proceeds distally, all of which migrate out of the glands onto the villi, but also protein- (enzyme-) secreting Paneth cells that remain in the glands http://purl.obolibrary.org/obo/MP_0004842 abnormal large intestine crypts of Lieberkuhn morphology http://purl.obolibrary.org/obo/MP_0000490 abnormal crypts of Lieberkuhn morphology any structural anomaly of the tubular intestinal glands found in the mucosal membranes of the large intestine http://purl.obolibrary.org/obo/MP_0004843 abnormal Paneth cell morphology http://purl.obolibrary.org/obo/MP_0004841 abnormal small intestine crypts of Lieberkuhn morphology any structural anomaly of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine http://purl.obolibrary.org/obo/MP_0004844 abnormal vestibuloocular reflex http://purl.obolibrary.org/obo/MP_0004742 abnormal vestibular system physiology any anomaly in the nystagmus or deviation of the eyes in response to stimulation of the vestibular system in which impulses are conveyed from the semicircular canals and the otolithic membrane to the oculomotor nerve; this stimulation may occur by angular acceleration or deceleration or by irrigation of the ear with hot or cold water; normally, this reflex functions to maintain a stable retinal image during head rotation by generating appropriate compensatory eye movements http://purl.obolibrary.org/obo/MP_0004845 absent vestibuloocular reflex http://purl.obolibrary.org/obo/MP_0004844 abnormal vestibuloocular reflex absence of nystagmus or deviation of the eyes in response to stimulation of the vestibular system http://purl.obolibrary.org/obo/MP_0004846 absent skeletal muscle http://purl.obolibrary.org/obo/MP_0000759 abnormal skeletal muscle morphology absence of any of the striated muscle fibers connected at either or both extremities with the bony framework of the body http://purl.obolibrary.org/obo/MP_0004850 abnormal testis weight http://purl.obolibrary.org/obo/MP_0004849 abnormal testis size anomaly in the average weight of the male reproductive glands http://purl.obolibrary.org/obo/MP_0004851 increased testis weight http://purl.obolibrary.org/obo/MP_0004850 abnormal testis weight greater average weight of the male reproductive glands http://purl.obolibrary.org/obo/MP_0004852 decreased testis weight http://purl.obolibrary.org/obo/MP_0004850 abnormal testis weight reduced average weight of the male reproductive glands http://purl.obolibrary.org/obo/MP_0004854 abnormal ovary weight http://purl.obolibrary.org/obo/MP_0004853 abnormal ovary size anomaly in the average weight of the female reproductive gland containing the germ cells http://purl.obolibrary.org/obo/MP_0004855 increased ovary weight http://purl.obolibrary.org/obo/MP_0004854 abnormal ovary weight greater average weight of the female reproductive gland containing the germ cells http://purl.obolibrary.org/obo/MP_0004856 decreased ovary weight http://purl.obolibrary.org/obo/MP_0004854 abnormal ovary weight reduction in the average weight of the female reproductive gland containing the germ cells http://purl.obolibrary.org/obo/MP_0004860 dilated kidney collecting duct http://purl.obolibrary.org/obo/MP_0004754 abnormal kidney collecting duct morphology stretched or widened aperture of the luminal space of the collecting ducts http://purl.obolibrary.org/obo/MP_0004861 abnormal Raphe nucleus morphology http://purl.obolibrary.org/obo/MP_0005277 abnormal brainstem morphology any structural anomaly of the subgroup of the reticular nuclei of the brain stem that are located in and along the median plane of the medulla oblongata, pons, and mesencephalon that include neurons that synthesize serotonin and extend ascending fibers to parts of the limbic system and descending fibers to other brain stem nuclei, the medulla oblongata, and the pons http://purl.obolibrary.org/obo/MP_0004862 small scala tympani http://purl.obolibrary.org/obo/MP_0003167 abnormal scala tympani morphology volume reduction of the division of the spiral canal of the cochlea lying on the basal side of the spiral lamina http://purl.obolibrary.org/obo/MP_0004863 thin spiral ligament http://purl.obolibrary.org/obo/MP_0004288 abnormal spiral ligament morphology reduced thickness of the periosteal lining of the bony cochlea that forms the outer wall of the cochlear duct to which the basal lamina attaches http://purl.obolibrary.org/obo/MP_0004864 spiral ligament degeneration http://purl.obolibrary.org/obo/MP_0004288 abnormal spiral ligament morphology degeneration or loss of the thickened periosteal lining of the bony cochlea that forms the outer wall of the cochlear duct to which the basal lamina attaches http://purl.obolibrary.org/obo/MP_0004865 abnormal platelet calcium level http://purl.obolibrary.org/obo/MP_0004721 abnormal platelet dense granule morphology anomaly in the amount in the platelet of calcium http://purl.obolibrary.org/obo/MP_0004866 increased platelet calcium level http://purl.obolibrary.org/obo/MP_0004865 abnormal platelet calcium level increased concentration in the platelet of calcium http://purl.obolibrary.org/obo/MP_0004867 decreased platelet calcium level http://purl.obolibrary.org/obo/MP_0004865 abnormal platelet calcium level decreased concentration in the platelet of calcium http://purl.obolibrary.org/obo/MP_0004868 increased endometrial carcinoma incidence http://purl.obolibrary.org/obo/MP_0009222 increased uterus tumor incidence greater than the expected number of a malignant neoplasm arising from the endometrial tissue, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0004869 frontal bone hypoplasia http://purl.obolibrary.org/obo/MP_0004377 small frontal bone underdevelopment or reduced size, usually due to a reduced number of cells, in the bone which forms the forehead and roof of the eye orbit http://purl.obolibrary.org/obo/MP_0004871 premaxilla hypoplasia http://purl.obolibrary.org/obo/MP_0004870 small premaxilla underdevelopment or reduced size, usually due to a reduced number of cells, in the anterior and interior portion of the maxilla http://purl.obolibrary.org/obo/MP_0004872 absent nasal septum http://purl.obolibrary.org/obo/MP_0002239 abnormal nasal septum morphology absence of the structure that separates the two nasal cavities http://purl.obolibrary.org/obo/MP_0004873 absent turbinates http://purl.obolibrary.org/obo/MP_0002244 abnormal turbinate morphology absence of the small curved bones that extend horizontally along the lateral wall of the nasal passage http://purl.obolibrary.org/obo/MP_0004875 increased mean systemic arterial blood pressure http://purl.obolibrary.org/obo/MP_0002842 increased systemic arterial blood pressure increase in the average arterial pressure during a single cardiac cycle http://purl.obolibrary.org/obo/MP_0004876 decreased mean systemic arterial blood pressure http://purl.obolibrary.org/obo/MP_0002843 decreased systemic arterial blood pressure decrease in the average arterial pressure during a single cardiac cycle http://purl.obolibrary.org/obo/MP_0004877 abnormal systemic vascular resistance http://purl.obolibrary.org/obo/MP_0005532 abnormal vascular resistance anomaly in the normal force opposing blood flow in the peripheral blood vessels http://purl.obolibrary.org/obo/MP_0004878 increased systemic vascular resistance http://purl.obolibrary.org/obo/MP_0004877 abnormal systemic vascular resistance increase in the normal force opposing blood flow in the peripheral blood vessels http://purl.obolibrary.org/obo/MP_0004879 decreased systemic vascular resistance http://purl.obolibrary.org/obo/MP_0004877 abnormal systemic vascular resistance reduction in the normal force opposing blood flow in the peripheral blood vessels http://purl.obolibrary.org/obo/MP_0004880 lung cysts http://purl.obolibrary.org/obo/MP_0001175 abnormal lung morphology abnormal membranous or fluid-filled sacs appearing in the lung http://purl.obolibrary.org/obo/MP_0004883 abnormal vascular wound healing http://purl.obolibrary.org/obo/MP_0005023 abnormal wound healing anomaly in the repair process of damaged blood vessels after injury http://purl.obolibrary.org/obo/MP_0004885 abnormal endolymph http://purl.obolibrary.org/obo/MP_0003878 abnormal ear physiology any alteration in the normal production (volume) or ionic homeostasis of the fluid contained within the membranous labyrinth of the inner ear; unlike perilymph, endolymph resembles intracellular fluid in composition and has a high concentration of potassium ion and a low concentration of sodium ion http://purl.obolibrary.org/obo/MP_0004886 increased endolymph production http://purl.obolibrary.org/obo/MP_0004885 abnormal endolymph increased synthesis of the fluid that is normally contained within the membranous labyrinth of the inner ear http://purl.obolibrary.org/obo/MP_0004887 decreased endolymph production http://purl.obolibrary.org/obo/MP_0004885 abnormal endolymph reduced synthesis of the fluid that is normally contained within the membranous labyrinth of the inner ear http://purl.obolibrary.org/obo/MP_0004888 abnormal perilymph http://purl.obolibrary.org/obo/MP_0003878 abnormal ear physiology change in the normal production (volume) or ionic homeostasis of the fluid contained within the osseous labyrinth, surrounding and protecting the membranous labyrinth; perilymph resembles extracellular fluid in composition, has a high concentration of sodium ion and a low concentration of potassium ion and, through the perilymphatic duct, is in continuity with cerebrospinal fluid http://purl.obolibrary.org/obo/MP_0004889 increased energy expenditure http://purl.obolibrary.org/obo/MP_0005450 abnormal energy expenditure increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten http://purl.obolibrary.org/obo/MP_0004890 decreased energy expenditure http://purl.obolibrary.org/obo/MP_0005450 abnormal energy expenditure decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten http://purl.obolibrary.org/obo/MP_0004891 abnormal adiponectin level http://purl.obolibrary.org/obo/MP_0003953 abnormal hormone level abnormal level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue http://purl.obolibrary.org/obo/MP_0004892 increased adiponectin level http://purl.obolibrary.org/obo/MP_0004891 abnormal adiponectin level greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue http://purl.obolibrary.org/obo/MP_0004893 decreased adiponectin level http://purl.obolibrary.org/obo/MP_0004891 abnormal adiponectin level reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue http://purl.obolibrary.org/obo/MP_0004894 uterus atrophy http://purl.obolibrary.org/obo/MP_0002637 small uterus acquired diminution of the size of the uterus associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0004895 vagina atrophy http://purl.obolibrary.org/obo/MP_0008983 small vagina acquired diminution of the size of the vagina associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0004896 abnormal endometrium morphology http://purl.obolibrary.org/obo/MP_0001120 abnormal uterus morphology any structural anomaly of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy http://purl.obolibrary.org/obo/MP_0004897 otosclerosis http://purl.obolibrary.org/obo/MP_0004289 abnormal bony labyrinth formation of spongy bone in the bony labyrinth of the ear, especially adjacent to the footplate of the stapes; it may cause bony ankylosis of the stapes, resulting in conductive hearing loss; cochlear otosclerosis results in sensorineural hearing loss http://purl.obolibrary.org/obo/MP_0004898 uterine hemorrhage http://purl.obolibrary.org/obo/MP_0009671 abnormal uterus physiology presence of bleeding in the uterus; often in response to failed pregnancy http://purl.obolibrary.org/obo/MP_0004899 absent squamosal bone http://purl.obolibrary.org/obo/MP_0004423 abnormal squamosal bone morphology absence of the thin, plate-like part of the temporal bone http://purl.obolibrary.org/obo/MP_0004900 absent zygomatic arch http://purl.obolibrary.org/obo/MP_0004469 abnormal zygomatic arch morphology absence of the bony arch that extends along the side or front of the skull beneath the eye socket and is formed by the temporal process of the zygomatic bone and the zygomatic process of the temporal bone http://purl.obolibrary.org/obo/MP_0004903 abnormal uterus weight http://purl.obolibrary.org/obo/MP_0004902 abnormal uterus size anomaly in the weight of the female organ of gestation http://purl.obolibrary.org/obo/MP_0004904 increased uterus weight http://purl.obolibrary.org/obo/MP_0004903 abnormal uterus weight increase in the weight of the female organ of gestation http://purl.obolibrary.org/obo/MP_0004905 decreased uterus weight http://purl.obolibrary.org/obo/MP_0004903 abnormal uterus weight reduction in the weight of the female organ of gestation http://purl.obolibrary.org/obo/MP_0004908 abnormal seminal vesicle weight http://purl.obolibrary.org/obo/MP_0004907 abnormal seminal vesicle size anomaly in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens http://purl.obolibrary.org/obo/MP_0004909 increased seminal vesicle weight http://purl.obolibrary.org/obo/MP_0004908 abnormal seminal vesicle weight increase in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens http://purl.obolibrary.org/obo/MP_0004910 decreased seminal vesicle weight http://purl.obolibrary.org/obo/MP_0004908 abnormal seminal vesicle weight reduction in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens http://purl.obolibrary.org/obo/MP_0004911 absent mandibular condyloid process http://purl.obolibrary.org/obo/MP_0004595 abnormal mandibular condyloid process morphology absence of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint http://purl.obolibrary.org/obo/MP_0004912 absent mandibular coronoid process http://purl.obolibrary.org/obo/MP_0004594 abnormal mandibular coronoid process morphology absence of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion) http://purl.obolibrary.org/obo/MP_0004913 absent mandibular angle http://purl.obolibrary.org/obo/MP_0004596 abnormal mandibular angle morphology absence of the portion of the mandible where the body of the mandible (horizontal portion) and the rami (perpendicular portions) meet; these normally unite nearly at right angles http://purl.obolibrary.org/obo/MP_0004914 absent ultimobranchial body http://purl.obolibrary.org/obo/MP_0003955 abnormal ultimobranchial body morphology absence of the outpocketing of the caudal-most branchial pouch of the embryo (interpreted as a fifth pouch in human or as the ventral component of the fourth pouch in mouse) that fuses with the thyroid diverticulum, ultimately giving rise to calcitonin-producing parafollicular cells (aka C-cells) which function in calcium homeostasis; in most mammals, these parafollicular cells fully disperse with the endodermally derived follicular cells of the thyroid by birth http://purl.obolibrary.org/obo/MP_0004915 abnormal Reichert's cartilage morphology http://purl.obolibrary.org/obo/MP_0003935 abnormal craniofacial development any structural anomaly of the cartilage found in the mesenchyme of the second pharyngeal arch in the embryo from which develop the stapes, styloid process, lesser horn and upper part of the body of the hyoid bone; its proximal end gives rise to the stylohyoid ligament http://purl.obolibrary.org/obo/MP_0004916 absent Reichert cartilage http://purl.obolibrary.org/obo/MP_0004915 abnormal Reichert's cartilage morphology absence of the cartilage normally found in the mesenchyme of the second branchial arch in the embryo, from which develop the stapes, the styloid processes, the stylohyoid ligaments, and the lesser cornua of the hyoid bone http://purl.obolibrary.org/obo/MP_0004917 abnormal T cell selection http://purl.obolibrary.org/obo/MP_0002145 abnormal T cell differentiation any anomaly in the process through which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation http://purl.obolibrary.org/obo/MP_0004918 abnormal negative T cell selection http://purl.obolibrary.org/obo/MP_0004917 abnormal T cell selection any anomaly in the process of elimination of immature T cells which react strongly with self-antigens http://purl.obolibrary.org/obo/MP_0004919 abnormal positive T cell selection http://purl.obolibrary.org/obo/MP_0004917 abnormal T cell selection any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death http://purl.obolibrary.org/obo/MP_0004920 increased placenta weight http://purl.obolibrary.org/obo/MP_0004260 enlarged placenta increase in the weight of the organ of metabolic interchange between fetus and mother http://purl.obolibrary.org/obo/MP_0004921 decreased placenta weight http://purl.obolibrary.org/obo/MP_0004259 small placenta reduction in the weight of the organ of metabolic interchange between fetus and mother http://purl.obolibrary.org/obo/MP_0004922 abnormal common crus morphology http://purl.obolibrary.org/obo/MP_0002428 abnormal semicircular canal morphology any structural anomaly in the united, nonampullary ends of the superior and posterior semicircular ducts of the inner ear http://purl.obolibrary.org/obo/MP_0004923 absent common crus http://purl.obolibrary.org/obo/MP_0004922 abnormal common crus morphology absence of the united, nonampullary ends of the superior and posterior semicircular ducts in the inner ear http://purl.obolibrary.org/obo/MP_0004925 decreased susceptibility to noise-induced hearing loss http://purl.obolibrary.org/obo/MP_0006334 abnormal susceptibility to hearing loss less than normal reduction in hearing sensitivity following exposure to acute noise that is injurious to the cochlea http://purl.obolibrary.org/obo/MP_0004926 abnormal epididymis size http://purl.obolibrary.org/obo/MP_0002631 abnormal epididymis morphology anomaly in the size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens http://purl.obolibrary.org/obo/MP_0004927 abnormal epididymis weight http://purl.obolibrary.org/obo/MP_0004926 abnormal epididymis size anomaly in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens http://purl.obolibrary.org/obo/MP_0004928 increased epididymis weight http://purl.obolibrary.org/obo/MP_0004931 enlarged epididymis increase in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens http://purl.obolibrary.org/obo/MP_0004929 decreased epididymis weight http://purl.obolibrary.org/obo/MP_0004930 small epididymis reduction in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens http://purl.obolibrary.org/obo/MP_0004930 small epididymis http://purl.obolibrary.org/obo/MP_0004926 abnormal epididymis size decrease in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens http://purl.obolibrary.org/obo/MP_0004931 enlarged epididymis http://purl.obolibrary.org/obo/MP_0004926 abnormal epididymis size increase in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens http://purl.obolibrary.org/obo/MP_0004932 epididymis hypoplasia http://purl.obolibrary.org/obo/MP_0004930 small epididymis underdevelopment or reduced size, usually due to a reduced number of cells, of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens http://purl.obolibrary.org/obo/MP_0004933 abnormal epididymis epithelium morphology http://purl.obolibrary.org/obo/MP_0002631 abnormal epididymis morphology any structural anomaly of the layer of secretory cells which lines the epididymis http://purl.obolibrary.org/obo/MP_0004934 epididymis epithelium degeneration http://purl.obolibrary.org/obo/MP_0004935 epididymis degeneration pathological deterioration of the layer of secretory cells which lines the epididymis http://purl.obolibrary.org/obo/MP_0004935 epididymis degeneration http://purl.obolibrary.org/obo/MP_0002631 abnormal epididymis morphology pathological deterioration of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens http://purl.obolibrary.org/obo/MP_0004936 impaired branching involved in ureteric bud morphogenesis http://purl.obolibrary.org/obo/MP_0010981 abnormal branching involved in ureteric bud morphogenesis partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney http://purl.obolibrary.org/obo/MP_0004938 dilated vasculature http://purl.obolibrary.org/obo/MP_0001614 abnormal blood vessel morphology stretched or widened aperture of the luminal space of the network of tubes that carries blood through the body http://purl.obolibrary.org/obo/MP_0004940 abnormal B-1 B cell morphology http://purl.obolibrary.org/obo/MP_0008171 abnormal mature B cell morphology any structural anomaly of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and are enriched for self-reactivity; B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas http://purl.obolibrary.org/obo/MP_0004941 abnormal regulatory T cell morphology http://purl.obolibrary.org/obo/MP_0008037 abnormal T cell morphology any structural anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or Tregs) and other T cell types that have suppressor function http://purl.obolibrary.org/obo/MP_0004942 abnormal B cell selection http://purl.obolibrary.org/obo/MP_0002144 abnormal B cell differentiation anomaly in the process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival http://purl.obolibrary.org/obo/MP_0004943 abnormal B cell positive selection http://purl.obolibrary.org/obo/MP_0004942 abnormal B cell selection any anomaly in the process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival http://purl.obolibrary.org/obo/MP_0004944 abnormal B cell negative selection http://purl.obolibrary.org/obo/MP_0004942 abnormal B cell selection any anomaly in the process through which B cells which react strongly with self-antigens are eliminated, usually through anergy or deletion http://purl.obolibrary.org/obo/MP_0004946 abnormal regulatory T cell physiology http://purl.obolibrary.org/obo/MP_0002444 abnormal T cell physiology any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or Tregs) and other T cell types that have suppressor function http://purl.obolibrary.org/obo/MP_0004948 abnormal neuronal precursor proliferation http://purl.obolibrary.org/obo/MP_0009967 abnormal neuron proliferation any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division http://purl.obolibrary.org/obo/MP_0004949 absent neuronal precursor cells http://purl.obolibrary.org/obo/MP_0004981 decreased neuronal precursor cell number absence of the neuroblast embryonic cells that develop into nerve cells or neurons http://purl.obolibrary.org/obo/MP_0004950 abnormal brain vasculature morphology http://purl.obolibrary.org/obo/MP_0002152 abnormal brain morphology any structural anomaly of the blood vessel network of the brain http://purl.obolibrary.org/obo/MP_0004951 abnormal spleen weight http://purl.obolibrary.org/obo/MP_0002224 abnormal spleen size anomaly in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets http://purl.obolibrary.org/obo/MP_0004952 increased spleen weight http://purl.obolibrary.org/obo/MP_0004951 abnormal spleen weight greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets http://purl.obolibrary.org/obo/MP_0004953 decreased spleen weight http://purl.obolibrary.org/obo/MP_0004951 abnormal spleen weight reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets http://purl.obolibrary.org/obo/MP_0004954 abnormal thymus weight http://purl.obolibrary.org/obo/MP_0002364 abnormal thymus size anomaly in the average weight of the primary lymphoid organ that is required for maturation of T cells http://purl.obolibrary.org/obo/MP_0004955 increased thymus weight http://purl.obolibrary.org/obo/MP_0004954 abnormal thymus weight greater than average weight of the primary lymphoid organ that is required for maturation of T cells http://purl.obolibrary.org/obo/MP_0004956 decreased thymus weight http://purl.obolibrary.org/obo/MP_0004954 abnormal thymus weight reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells http://purl.obolibrary.org/obo/MP_0004960 abnormal prostate gland weight http://purl.obolibrary.org/obo/MP_0004959 abnormal prostate gland size anomaly in the average weight of the gland in males that secretes part of the seminiferous fluid http://purl.obolibrary.org/obo/MP_0004961 increased prostate gland weight http://purl.obolibrary.org/obo/MP_0004960 abnormal prostate gland weight greater than average weight of the gland in males that secretes part of the seminiferous fluid http://purl.obolibrary.org/obo/MP_0004962 decreased prostate gland weight http://purl.obolibrary.org/obo/MP_0004960 abnormal prostate gland weight reduction in the average weight of the gland in males that secretes part of the seminiferous fluid http://purl.obolibrary.org/obo/MP_0004964 absent inner cell mass http://purl.obolibrary.org/obo/MP_0002718 abnormal inner cell mass morphology absence of the cells of the blastocyst that develop into the body of the embryo http://purl.obolibrary.org/obo/MP_0004965 inner cell mass degeneration http://purl.obolibrary.org/obo/MP_0002718 abnormal inner cell mass morphology a retrogressive impairment of function or destruction of the cells of the blastocyst that develop into the body of the embryo http://purl.obolibrary.org/obo/MP_0004966 abnormal inner cell mass proliferation http://purl.obolibrary.org/obo/MP_0001672 abnormal embryogenesis/ development any anomaly in the ability of the inner cell mass population to undergo rapid expansion by cell division http://purl.obolibrary.org/obo/MP_0004967 abnormal kidney epithelium morphology http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology any structural anomaly of the cellular avascular layer of the kidney luminar surfaces http://purl.obolibrary.org/obo/MP_0004968 kidney epithelium hyperplasia http://purl.obolibrary.org/obo/MP_0004967 abnormal kidney epithelium morphology overdevelopment or increased size, usually due an increased number of cells of the cellular avascular layer of the kidney luminar surfaces http://purl.obolibrary.org/obo/MP_0004969 pale kidney http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition http://purl.obolibrary.org/obo/MP_0004970 kidney atrophy http://purl.obolibrary.org/obo/MP_0002989 small kidney acquired diminution of the size of the kidney associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0004971 dermal hyperplasia http://purl.obolibrary.org/obo/MP_0001243 abnormal dermal layer morphology overdevelopment or increased size, usually due an increased number of cells in the dermal layer of the skin http://purl.obolibrary.org/obo/MP_0004972 abnormal regulatory T cell number http://purl.obolibrary.org/obo/MP_0004941 abnormal regulatory T cell morphology deviation from the average count of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity http://purl.obolibrary.org/obo/MP_0004973 increased regulatory T cell number http://purl.obolibrary.org/obo/MP_0004972 abnormal regulatory T cell number greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity http://purl.obolibrary.org/obo/MP_0004974 decreased regulatory T cell number http://purl.obolibrary.org/obo/MP_0004972 abnormal regulatory T cell number reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity http://purl.obolibrary.org/obo/MP_0004975 absent regulatory T cells http://purl.obolibrary.org/obo/MP_0008070 absent T cells absence of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity http://purl.obolibrary.org/obo/MP_0004976 abnormal B-1 B cell number http://purl.obolibrary.org/obo/MP_0004940 abnormal B-1 B cell morphology deviation from the normal count of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity http://purl.obolibrary.org/obo/MP_0004977 increased B-1 B cell number http://purl.obolibrary.org/obo/MP_0008210 increased mature B cell number greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity http://purl.obolibrary.org/obo/MP_0004978 decreased B-1 B cell number http://purl.obolibrary.org/obo/MP_0008211 decreased mature B cell number reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity http://purl.obolibrary.org/obo/MP_0004979 abnormal neuronal precursor cell number http://purl.obolibrary.org/obo/MP_0009937 abnormal neuron differentiation deviation from the normal count of the neuroblast embryonic cells that develop into nerve cells or neurons http://purl.obolibrary.org/obo/MP_0004980 increased neuronal precursor cell number http://purl.obolibrary.org/obo/MP_0004979 abnormal neuronal precursor cell number increased number of the neuroblast embryonic cells that develop into nerve cells or neurons http://purl.obolibrary.org/obo/MP_0004981 decreased neuronal precursor cell number http://purl.obolibrary.org/obo/MP_0004979 abnormal neuronal precursor cell number reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons http://purl.obolibrary.org/obo/MP_0004982 abnormal osteoclast morphology http://purl.obolibrary.org/obo/MP_0003795 abnormal bone structure any structural anomaly of the specialized phagocytic cells associated with the absorption and removal of the mineralized matrix of bone tissue http://purl.obolibrary.org/obo/MP_0004983 abnormal osteoclast cell number http://purl.obolibrary.org/obo/MP_0004982 abnormal osteoclast morphology deviation from the average number of the specialized phagocytic cells associated with the absorption and removal of the mineralized matrix of bone tissue http://purl.obolibrary.org/obo/MP_0004984 increased osteoclast cell number http://purl.obolibrary.org/obo/MP_0005425 increased macrophage cell number greater than average number of the specialized phagocytic cells associated with the absorption and removal of the mineralized matrix of bone tissue http://purl.obolibrary.org/obo/MP_0004985 decreased osteoclast cell number http://purl.obolibrary.org/obo/MP_0004983 abnormal osteoclast cell number reduced number of the specialized phagocytic cells associated with the absorption and removal of the mineralized matrix of bone tissue http://purl.obolibrary.org/obo/MP_0004986 abnormal osteoblast morphology http://purl.obolibrary.org/obo/MP_0003795 abnormal bone structure any structural anomaly of a skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell http://purl.obolibrary.org/obo/MP_0004987 abnormal osteoblast cell number http://purl.obolibrary.org/obo/MP_0004986 abnormal osteoblast morphology deviation from the average number of the skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell http://purl.obolibrary.org/obo/MP_0004988 increased osteoblast cell number http://purl.obolibrary.org/obo/MP_0004987 abnormal osteoblast cell number greater than average number of skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell http://purl.obolibrary.org/obo/MP_0004989 decreased osteoblast cell number http://purl.obolibrary.org/obo/MP_0004987 abnormal osteoblast cell number reduction in the number of skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell http://purl.obolibrary.org/obo/MP_0004990 abnormal ciliary ganglion morphology http://purl.obolibrary.org/obo/MP_0001034 abnormal parasympathetic ganglion morphology any structural anomaly of the parasympathetic ganglia in the orbit behind the eye that receives preganglionic innervation through the oculomotor nerve http://purl.obolibrary.org/obo/MP_0004991 decreased bone strength http://purl.obolibrary.org/obo/MP_0001542 abnormal bone strength reduced ability of bone to endure the application of force without yielding or breaking http://purl.obolibrary.org/obo/MP_0004992 increased bone resorption http://purl.obolibrary.org/obo/MP_0004945 abnormal bone resorption greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts http://purl.obolibrary.org/obo/MP_0004993 decreased bone resorption http://purl.obolibrary.org/obo/MP_0004945 abnormal bone resorption reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts http://purl.obolibrary.org/obo/MP_0004994 abnormal brain wave pattern http://purl.obolibrary.org/obo/MP_0002272 abnormal nervous system electrophysiology any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy) http://purl.obolibrary.org/obo/MP_0004995 abnormal B cell clonal deletion http://purl.obolibrary.org/obo/MP_0005001 abnormal clonal deletion a defect in the process of removal by apoptosis of immature B lymphocytes that interact with self antigens during maturation http://purl.obolibrary.org/obo/MP_0004997 increased CNS synapse formation http://purl.obolibrary.org/obo/MP_0004996 abnormal CNS synapse formation greater frequency of the process of generating the initial connections between an axon and effector tissue or neuron http://purl.obolibrary.org/obo/MP_0004998 decreased CNS synapse formation http://purl.obolibrary.org/obo/MP_0004996 abnormal CNS synapse formation a reduction in the frequency of the process of generating the initial connections between an axon and effector tissue or neuron http://purl.obolibrary.org/obo/MP_0004999 abnormal blood-inner ear barrier function http://purl.obolibrary.org/obo/MP_0003878 abnormal ear physiology anomaly in the function of the group of barriers and transport systems which regulate the transport of various substances from blood to inner ear tissue and maintain the microhomeostasis and functional integrity of the inner ear; the endothelial cells of the inner ear blood capillaries, linked to each other by tight junctions, represent the main component of the blood-inner ear barrier http://purl.obolibrary.org/obo/MP_0005000 abnormal immune tolerance http://purl.obolibrary.org/obo/MP_0001790 abnormal immune system physiology anomaly in the process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it http://purl.obolibrary.org/obo/MP_0005001 abnormal clonal deletion http://purl.obolibrary.org/obo/MP_0005000 abnormal immune tolerance a defect in the process of removal of immature lymphocytes that interact with self antigens during maturation http://purl.obolibrary.org/obo/MP_0005002 abnormal T cell clonal deletion http://purl.obolibrary.org/obo/MP_0005001 abnormal clonal deletion a defect in the process of removal of immature T lymphocytes that interact with self antigens during maturation http://purl.obolibrary.org/obo/MP_0005004 abnormal lymphocyte anergy http://purl.obolibrary.org/obo/MP_0005000 abnormal immune tolerance anomaly in the process of establishing a state of functional inactivation of self-reactive lymphocytes http://purl.obolibrary.org/obo/MP_0005006 abnormal osteoblast physiology http://purl.obolibrary.org/obo/MP_0002998 abnormal bone remodeling any functional anomaly of a skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell http://purl.obolibrary.org/obo/MP_0005011 increased eosinophil cell number http://purl.obolibrary.org/obo/MP_0002602 abnormal eosinophil cell number greater than normal eosinophil numbers http://purl.obolibrary.org/obo/MP_0005012 decreased eosinophil cell number http://purl.obolibrary.org/obo/MP_0002602 abnormal eosinophil cell number fewer than normal eosinophil numbers http://purl.obolibrary.org/obo/MP_0005013 increased lymphocyte cell number http://purl.obolibrary.org/obo/MP_0000717 abnormal lymphocyte cell number greater than normal number of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells http://purl.obolibrary.org/obo/MP_0005017 decreased B cell number http://purl.obolibrary.org/obo/MP_0005016 decreased lymphocyte cell number fewer than normal number of cells that are formed in the bone marrow, migrate to the peripheral lymphatic system, and mature into plasma cells or memory cells; these cells are involved in humoral immunity http://purl.obolibrary.org/obo/MP_0005022 abnormal immature B cell morphology http://purl.obolibrary.org/obo/MP_0004939 abnormal B cell morphology any structural anomaly of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity http://purl.obolibrary.org/obo/MP_0005026 decreased susceptibility to parasitic infection http://purl.obolibrary.org/obo/MP_0020184 altered susceptibility to parasitic infection reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites http://purl.obolibrary.org/obo/MP_0005027 increased susceptibility to parasitic infection http://purl.obolibrary.org/obo/MP_0020184 altered susceptibility to parasitic infection greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites http://purl.obolibrary.org/obo/MP_0005028 abnormal trophectoderm morphology http://purl.obolibrary.org/obo/MP_0011203 abnormal parietal yolk sac morphology any structural anomaly outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo's means of nutrition http://purl.obolibrary.org/obo/MP_0005030 absent amnion http://purl.obolibrary.org/obo/MP_0005029 abnormal amnion morphology absence of the thin innermost layer of the extraembryonic membranes that contains the amniotic fluid; the membrane forms a closed sac in which the embryo and later, the fetus, is suspended and protected http://purl.obolibrary.org/obo/MP_0005035 perianal ulcer http://purl.obolibrary.org/obo/MP_0005034 abnormal anus morphology lesion around or near the anus http://purl.obolibrary.org/obo/MP_0005037 mucous diarrhea http://purl.obolibrary.org/obo/MP_0005036 diarrhea presence of considerable mucous in the stools http://purl.obolibrary.org/obo/MP_0005039 hypoxia http://purl.obolibrary.org/obo/MP_0001574 abnormal oxygen level reduced oxygenation of body tissues resulting in the decreased pressure of this component of body gases; commonly due to hypoxemia http://purl.obolibrary.org/obo/MP_0005040 abnormal MHC II cell surface expression on macrophages http://purl.obolibrary.org/obo/MP_0005042 abnormal level of surface class II molecules anomaly in the ability of macrophages to express major histocompatibility complex class II at the cell surface http://purl.obolibrary.org/obo/MP_0005041 abnormal antigen presentation via MHC class II http://purl.obolibrary.org/obo/MP_0002453 abnormal B lymphocyte antigen presentation anomaly in the process by which peptide, bound to major histocompatibility complex class II, is presented to lymphocytes at the surface of antigen presenting cells http://purl.obolibrary.org/obo/MP_0005042 abnormal level of surface class II molecules http://purl.obolibrary.org/obo/MP_0005041 abnormal antigen presentation via MHC class II deviation from the normal concentration of major histocompatibility complex class II molecules expressed at the cell surface http://purl.obolibrary.org/obo/MP_0005043 defective assembly of class II molecules http://purl.obolibrary.org/obo/MP_0005041 abnormal antigen presentation via MHC class II impaired production of major histocompatibility complex class II molecules http://purl.obolibrary.org/obo/MP_0005044 sepsis http://purl.obolibrary.org/obo/MP_0005025 abnormal response to infection presence of various pathogenic organisms, or their toxins, in the blood or tissues http://purl.obolibrary.org/obo/MP_0005046 absent spleen white pulp http://purl.obolibrary.org/obo/MP_0002357 abnormal spleen white pulp morphology absence of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies http://purl.obolibrary.org/obo/MP_0005047 enlarged celiac lymph nodes http://purl.obolibrary.org/obo/MP_0009626 abnormal celiac lymph node morphology increased size of the celiac lymph nodes http://purl.obolibrary.org/obo/MP_0005058 abnormal lysosome morphology http://purl.obolibrary.org/obo/MP_0000358 abnormal cell morphology any structural anomaly of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases http://purl.obolibrary.org/obo/MP_0005059 lysosomal protein accumulation http://purl.obolibrary.org/obo/MP_0003172 abnormal lysosome physiology buildup of protein in the lysosome http://purl.obolibrary.org/obo/MP_0005060 accumulation of giant lysosomes in kidney/renal tubule cells http://purl.obolibrary.org/obo/MP_0005058 abnormal lysosome morphology buildup of contents in lysosomes in cells of the kidney tubules http://purl.obolibrary.org/obo/MP_0005068 abnormal NK cell morphology http://purl.obolibrary.org/obo/MP_0002619 abnormal lymphocyte morphology any structural anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells http://purl.obolibrary.org/obo/MP_0005070 impaired natural killer cell mediated cytotoxicity http://purl.obolibrary.org/obo/MP_0011719 abnormal natural killer cell mediated cytotoxicity impaired ability of directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors http://purl.obolibrary.org/obo/MP_0005071 enlarged hair follicle melanin granules http://purl.obolibrary.org/obo/MP_0005072 abnormal hair follicle melanin granule morphology increased size of the pigment particles located in the hair follicle http://purl.obolibrary.org/obo/MP_0005074 impaired granulocyte bactericidal activity http://purl.obolibrary.org/obo/MP_0002462 abnormal granulocyte physiology inability or reduced ability of neutrophils, eosinophils, or basophils to kill bacteria http://purl.obolibrary.org/obo/MP_0005075 abnormal melanosome morphology http://purl.obolibrary.org/obo/MP_0002877 abnormal melanocyte morphology any structural anomaly of the tissue-specific cytoplasmic organelles within which melanin pigments are synthesized and stored http://purl.obolibrary.org/obo/MP_0005077 abnormal melanogenesis http://purl.obolibrary.org/obo/MP_0001186 pigmentation phenotype anomaly in the biosynthetic pathway of melanin formation in cells http://purl.obolibrary.org/obo/MP_0005078 abnormal cytotoxic T cell physiology http://purl.obolibrary.org/obo/MP_0004392 abnormal CD8-positive, alpha-beta T cell physiology any functional anomaly of the subset of CD8-positive T lymphocytes capable of directly killing appropriately targeted cells http://purl.obolibrary.org/obo/MP_0005079 decreased cytotoxic T cell cytolysis http://purl.obolibrary.org/obo/MP_0013280 abnormal cytotoxic T cell cytolysis impaired ability of cytotoxic T cells to induce pathological breakdown of target cells by the destruction of their outer membrane http://purl.obolibrary.org/obo/MP_0005081 abnormal dermis reticular layer morphology http://purl.obolibrary.org/obo/MP_0001243 abnormal dermal layer morphology any structural anomaly of the thicker, deeper layer of the dermis, comprised of criss-crossing collagen fibers that form a strong elastic network and also containing blood and lymph vessels, nerves and nerve endings, and hair follicles http://purl.obolibrary.org/obo/MP_0005087 decreased acute inflammation http://purl.obolibrary.org/obo/MP_0002498 abnormal acute inflammation less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response http://purl.obolibrary.org/obo/MP_0005088 increased acute inflammation http://purl.obolibrary.org/obo/MP_0002498 abnormal acute inflammation greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response http://purl.obolibrary.org/obo/MP_0005089 decreased double-negative T cell number http://purl.obolibrary.org/obo/MP_0005018 decreased T cell number reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 http://purl.obolibrary.org/obo/MP_0005090 increased double-negative T cell number http://purl.obolibrary.org/obo/MP_0005015 increased T cell number greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 http://purl.obolibrary.org/obo/MP_0005091 increased double-positive T cell number http://purl.obolibrary.org/obo/MP_0005015 increased T cell number greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8 http://purl.obolibrary.org/obo/MP_0005092 decreased double-positive T cell number http://purl.obolibrary.org/obo/MP_0005018 decreased T cell number less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8 http://purl.obolibrary.org/obo/MP_0005093 decreased B cell proliferation http://purl.obolibrary.org/obo/MP_0005153 abnormal B cell proliferation absent or reduced expansion rate of the B cell population by cell division in response to stimuli http://purl.obolibrary.org/obo/MP_0005094 abnormal T cell proliferation http://purl.obolibrary.org/obo/MP_0001828 abnormal T cell activation anomaly in the ability of a naive T cell population to undergo rapid expansion by cell division in response to stimuli http://purl.obolibrary.org/obo/MP_0005095 decreased T cell proliferation http://purl.obolibrary.org/obo/MP_0005094 abnormal T cell proliferation reduction in the ability of a naive T cell population to undergo rapid expansion by cell division in response to stimuli http://purl.obolibrary.org/obo/MP_0005096 erythroblastosis http://purl.obolibrary.org/obo/MP_0011178 increased erythroblast number presence of erythroblasts in great number in the blood http://purl.obolibrary.org/obo/MP_0005097 polychromatophilia http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains http://purl.obolibrary.org/obo/MP_0005098 abnormal optic choroid morphology http://purl.obolibrary.org/obo/MP_0005197 abnormal uvea morphology any structural anomaly of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera http://purl.obolibrary.org/obo/MP_0005099 abnormal ciliary body morphology http://purl.obolibrary.org/obo/MP_0005194 abnormal anterior uvea morphology any structural anomaly of the thickened portion of the vascular tunic, which lies between the choroid and the iris http://purl.obolibrary.org/obo/MP_0005100 abnormal choroid pigmentation http://purl.obolibrary.org/obo/MP_0005098 abnormal optic choroid morphology anomalous coloring of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera http://purl.obolibrary.org/obo/MP_0005101 abnormal ciliary body pigmentation http://purl.obolibrary.org/obo/MP_0005200 abnormal eye pigment epithelium morphology anomalous coloring of the thickened portion of the vascular tunic, which lies between the choroid and the iris http://purl.obolibrary.org/obo/MP_0005102 abnormal iris pigmentation http://purl.obolibrary.org/obo/MP_0001324 abnormal eye pigmentation anomalous coloring of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye http://purl.obolibrary.org/obo/MP_0005103 abnormal retinal pigmentation http://purl.obolibrary.org/obo/MP_0005201 abnormal retinal pigment epithelium morphology anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors http://purl.obolibrary.org/obo/MP_0005104 abnormal tarsal bone morphology http://purl.obolibrary.org/obo/MP_0002115 abnormal limb bone morphology any structural anomaly of any of the eight bones of the instep of the paw/foot: tibiale, talus, calcaneus, navicular, 3 cuneiform, and cuboid bones http://purl.obolibrary.org/obo/MP_0005108 abnormal ulna morphology http://purl.obolibrary.org/obo/MP_0011504 abnormal limb long bone morphology any structural anomaly of the medial and larger of the two bones of the forearm http://purl.obolibrary.org/obo/MP_0005109 abnormal talus morphology http://purl.obolibrary.org/obo/MP_0005104 abnormal tarsal bone morphology any structural anomaly of the bone that articulates with the tibia and fibula http://purl.obolibrary.org/obo/MP_0005110 absent talus http://purl.obolibrary.org/obo/MP_0005109 abnormal talus morphology absence of the bone that articulates with the tibia and fibula http://purl.obolibrary.org/obo/MP_0005111 hyperdipsia http://purl.obolibrary.org/obo/MP_0001422 abnormal drinking behavior intense thirst that is relatively temporary http://purl.obolibrary.org/obo/MP_0005112 abnormal spinal cord ventral horn morphology http://purl.obolibrary.org/obo/MP_0008503 abnormal spinal cord grey matter morphology any structural anomaly of the ventral grey column of the spinal cord http://purl.obolibrary.org/obo/MP_0005113 decreased spinal cord ventral horn cell number http://purl.obolibrary.org/obo/MP_0005112 abnormal spinal cord ventral horn morphology fewer than the expected number of cells in the ventral grey column of the spinal cord http://purl.obolibrary.org/obo/MP_0005114 premature hair loss http://purl.obolibrary.org/obo/MP_0002073 abnormal hair growth release of fur at an earlier than expected time http://purl.obolibrary.org/obo/MP_0005116 abnormal circulating pituitary hormone level http://purl.obolibrary.org/obo/MP_0005418 abnormal circulating hormone level aberration in the blood concentration of any of the hormones secreted by the pituitary http://purl.obolibrary.org/obo/MP_0005119 decreased circulating thyroid-stimulating hormone level http://purl.obolibrary.org/obo/MP_0005134 decreased thyroid-stimulating hormone level reduced amount in the blood of the hormone that stimulates the growth and function of the thyroid gland http://purl.obolibrary.org/obo/MP_0005120 decreased circulating growth hormone level http://purl.obolibrary.org/obo/MP_0005136 decreased growth hormone level less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization http://purl.obolibrary.org/obo/MP_0005121 decreased circulating prolactin level http://purl.obolibrary.org/obo/MP_0005138 decreased prolactin level less than expected blood concentration of the hormone that stimulates milk secretion http://purl.obolibrary.org/obo/MP_0005122 increased circulating thyroid-stimulating hormone level http://purl.obolibrary.org/obo/MP_0005135 increased thyroid-stimulating hormone level greater amount in the blood of the hormone that stimulates the growth and function of the thyroid gland http://purl.obolibrary.org/obo/MP_0005123 increased circulating growth hormone level http://purl.obolibrary.org/obo/MP_0005137 increased growth hormone level greater than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization http://purl.obolibrary.org/obo/MP_0005124 increased circulating prolactin level http://purl.obolibrary.org/obo/MP_0005139 increased prolactin level greater than expected blood concentration of the hormone that stimulates milk secretion http://purl.obolibrary.org/obo/MP_0005134 decreased thyroid-stimulating hormone level http://purl.obolibrary.org/obo/MP_0003972 decreased pituitary hormone level reduced amount of the hormone that stimulates the growth and function of the thyroid gland http://purl.obolibrary.org/obo/MP_0005135 increased thyroid-stimulating hormone level http://purl.obolibrary.org/obo/MP_0003973 increased pituitary hormone level greater amount of the hormone that stimulates the growth and function of the thyroid gland http://purl.obolibrary.org/obo/MP_0005136 decreased growth hormone level http://purl.obolibrary.org/obo/MP_0003972 decreased pituitary hormone level less than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization http://purl.obolibrary.org/obo/MP_0005137 increased growth hormone level http://purl.obolibrary.org/obo/MP_0003973 increased pituitary hormone level greater than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization http://purl.obolibrary.org/obo/MP_0005138 decreased prolactin level http://purl.obolibrary.org/obo/MP_0003972 decreased pituitary hormone level less than expected concentration of the hormone that stimulates milk secretion http://purl.obolibrary.org/obo/MP_0005139 increased prolactin level http://purl.obolibrary.org/obo/MP_0003973 increased pituitary hormone level greater than expected concentration of the hormone that stimulates milk secretion http://purl.obolibrary.org/obo/MP_0005140 decreased cardiac muscle contractility http://purl.obolibrary.org/obo/MP_0002972 abnormal cardiac muscle contractility inability or reduced ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max, fractional shortening (FS), velocity of circumferential fiber shortening (Vcfc), peak of aortic outflow velocity (PAV), and ventricular ejection fraction volume http://purl.obolibrary.org/obo/MP_0005141 liver hyperplasia http://purl.obolibrary.org/obo/MP_0000599 enlarged liver overdevelopment or increased size of the liver, usually due an increased number of cells http://purl.obolibrary.org/obo/MP_0005144 abnormal circulating VLDL cholesterol level http://purl.obolibrary.org/obo/MP_0020151 abnormal circulating non-HDL cholesterol level any anomaly in the amount in the blood of the lipoprotein:cholesterol complex that transports triglycerides from the intestine and liver to muscle and adipose tissue http://purl.obolibrary.org/obo/MP_0005145 increased circulating VLDL cholesterol level http://purl.obolibrary.org/obo/MP_0005144 abnormal circulating VLDL cholesterol level greater amount in the blood of the lipoprotein:cholesterol complex that transports triglycerides from the intestine and liver to muscle and adipose tissue http://purl.obolibrary.org/obo/MP_0005146 decreased circulating VLDL cholesterol level http://purl.obolibrary.org/obo/MP_0005144 abnormal circulating VLDL cholesterol level reduced amount in the blood of the lipoprotein:cholesterol complex that transports triglycerides from the intestine and liver to muscle and adipose tissue http://purl.obolibrary.org/obo/MP_0005148 seminal vesicle hypoplasia http://purl.obolibrary.org/obo/MP_0001157 small seminal vesicle underdevelopment or reduced size, usually due to a reduced number of cells, of one of the two folded, sac shaped glands that is a diverticulum of the ductus deferens http://purl.obolibrary.org/obo/MP_0005149 abnormal gubernaculum morphology http://purl.obolibrary.org/obo/MP_0005504 abnormal ligament morphology any structural anomaly of the genitoinguinal ligaments that, in the male, connect the fetal testis to the developing scrotum, and, in the female, connect the ovaries to the uterus http://purl.obolibrary.org/obo/MP_0005150 cachexia http://purl.obolibrary.org/obo/MP_0001263 weight loss general weight loss and wasting occurring in the course of chronic disease http://purl.obolibrary.org/obo/MP_0005151 diffuse hepatic necrosis http://purl.obolibrary.org/obo/MP_0001654 hepatic necrosis morphological changes resulting from disseminated pathological death of some or all liver tissue; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0005152 pancytopenia http://purl.obolibrary.org/obo/MP_0011182 decreased hematopoietic cell number reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood http://purl.obolibrary.org/obo/MP_0005153 abnormal B cell proliferation http://purl.obolibrary.org/obo/MP_0008217 abnormal B cell activation anomaly in the ability of the B cell population to undergo rapid expansion by cell division in response to stimuli http://purl.obolibrary.org/obo/MP_0005154 increased B cell proliferation http://purl.obolibrary.org/obo/MP_0005153 abnormal B cell proliferation greater than normal expansion rate of the B cell population by cell division in response to stimuli http://purl.obolibrary.org/obo/MP_0005155 herniated intestine http://purl.obolibrary.org/obo/MP_0000477 abnormal intestine morphology protrusion of any portion of the intestine from its normal anatomical position http://purl.obolibrary.org/obo/MP_0005156 bradykinesia http://purl.obolibrary.org/obo/MP_0003313 abnormal locomotor activation decreased spontaneity and movement, without external stimulus http://purl.obolibrary.org/obo/MP_0005157 holoprosencephaly http://purl.obolibrary.org/obo/MP_0000913 abnormal brain development presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development http://purl.obolibrary.org/obo/MP_0005158 ovary hypoplasia http://purl.obolibrary.org/obo/MP_0001127 small ovary underdevelopment or reduced size of the ovaries, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0005159 azoospermia http://purl.obolibrary.org/obo/MP_0004901 decreased male germ cell number a condition where there is no measurable level of spermatozoa in the semen http://purl.obolibrary.org/obo/MP_0005161 hematuria http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis presence of blood in the urine http://purl.obolibrary.org/obo/MP_0005162 carpoptosis http://purl.obolibrary.org/obo/MP_0000753 paralysis paralysis of the extensors of the wrist and fingers; most often caused by a lesion of the radial nerve http://purl.obolibrary.org/obo/MP_0005163 cyclopia http://purl.obolibrary.org/obo/MP_0001286 abnormal eye development a congenital defect in which the two orbits are united to form a single cavity containing one eye http://purl.obolibrary.org/obo/MP_0005167 abnormal blood-brain barrier function http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology anomaly in the function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood http://purl.obolibrary.org/obo/MP_0005168 abnormal female meiosis http://purl.obolibrary.org/obo/MP_0001931 abnormal oogenesis anomaly in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell http://purl.obolibrary.org/obo/MP_0005169 abnormal male meiosis http://purl.obolibrary.org/obo/MP_0001930 abnormal meiosis anomaly in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell http://purl.obolibrary.org/obo/MP_0005170 cleft lip http://purl.obolibrary.org/obo/MP_0012523 abnormal upper lip morphology defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences http://purl.obolibrary.org/obo/MP_0005171 absent coat pigmentation http://purl.obolibrary.org/obo/MP_0002075 abnormal coat/hair pigmentation fur or hair is devoid of coloration and appears white http://purl.obolibrary.org/obo/MP_0005172 decreased eye pigmentation http://purl.obolibrary.org/obo/MP_0005408 hypopigmentation the eye has less pigmentation than normal with a possible range of color from dark red, somewhat reduced in pigment, to pink, typical of albinism or ocular albinism http://purl.obolibrary.org/obo/MP_0005174 abnormal tail pigmentation http://purl.obolibrary.org/obo/MP_0002111 abnormal tail morphology anomaly in the coloration of the tail due to changes in the amount, shape, or distribution of cells producing pigment http://purl.obolibrary.org/obo/MP_0005175 non-pigmented tail tip http://purl.obolibrary.org/obo/MP_0013177 abnormal tail tip morphology lack of color at the end of the tail http://purl.obolibrary.org/obo/MP_0005176 eyelids fail to open http://purl.obolibrary.org/obo/MP_0004874 abnormal timing of postnatal eyelid opening eyes remain shut when eyelids are expected to be open http://purl.obolibrary.org/obo/MP_0005181 decreased circulating estradiol level http://purl.obolibrary.org/obo/MP_0005183 abnormal circulating estradiol level less than the normal blood concentration of this most potent naturally occurring estrogen in mammals http://purl.obolibrary.org/obo/MP_0005182 increased circulating estradiol level http://purl.obolibrary.org/obo/MP_0005183 abnormal circulating estradiol level greater than the normal blood concentration of this most potent naturally occurring estrogen in mammals http://purl.obolibrary.org/obo/MP_0005183 abnormal circulating estradiol level http://purl.obolibrary.org/obo/MP_0003369 abnormal circulating estrogen level aberration in the blood concentration of this most potent estrogen http://purl.obolibrary.org/obo/MP_0005184 abnormal circulating progesterone level http://purl.obolibrary.org/obo/MP_0011384 abnormal progesterone level anomaly in the blood concentration of the antiestrogenic steroid released by the corpus luteum that stimulates the uterus to prepare for pregnancy http://purl.obolibrary.org/obo/MP_0005185 decreased circulating progesterone level http://purl.obolibrary.org/obo/MP_0005184 abnormal circulating progesterone level reduced blood concentration of the antiestrogenic steroid released by the corpus luteum that stimulates the uterus to prepare for pregnancy http://purl.obolibrary.org/obo/MP_0005186 increased circulating progesterone level http://purl.obolibrary.org/obo/MP_0005184 abnormal circulating progesterone level increased blood concentration of the antiestrogenic steroid released by the corpus luteum that stimulates the uterus to prepare for pregnancy http://purl.obolibrary.org/obo/MP_0005188 small penis http://purl.obolibrary.org/obo/MP_0005187 abnormal penis morphology reduced size of the organ of copulation and urination in the male http://purl.obolibrary.org/obo/MP_0005190 osteomyelitis http://purl.obolibrary.org/obo/MP_0001846 increased inflammatory response bone inflammation http://purl.obolibrary.org/obo/MP_0005191 head tilt http://purl.obolibrary.org/obo/MP_0000436 abnormal head movements condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side http://purl.obolibrary.org/obo/MP_0005192 increased motor neuron number http://purl.obolibrary.org/obo/MP_0008947 increased neuron number greater than the normal number of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses http://purl.obolibrary.org/obo/MP_0005197 abnormal uvea morphology http://purl.obolibrary.org/obo/MP_0002092 abnormal eye morphology any structural anomaly of the pigmented vascular coat of the eyeball, consisting of the iris, ciliary body, and choroid http://purl.obolibrary.org/obo/MP_0005199 abnormal iris pigment epithelium http://purl.obolibrary.org/obo/MP_0005200 abnormal eye pigment epithelium morphology anomaly in the epithelial layer of the iris composed of cells containing pigment granules http://purl.obolibrary.org/obo/MP_0005200 abnormal eye pigment epithelium morphology http://purl.obolibrary.org/obo/MP_0001324 abnormal eye pigmentation any structural anomaly in the epithelial layer of the retina, ciliary body, or iris composed of cells containing pigment granules http://purl.obolibrary.org/obo/MP_0005201 abnormal retinal pigment epithelium morphology http://purl.obolibrary.org/obo/MP_0005200 abnormal eye pigment epithelium morphology any structural anomaly in the epithelial layer of the retina composed of cells containing pigment granules http://purl.obolibrary.org/obo/MP_0005202 lethargy http://purl.obolibrary.org/obo/MP_0003313 abnormal locomotor activation mild impairment of consciousness resulting in reduced alertness and awareness and/or sluggish behavior or inactivity; can be due to generalized brain dysfunction http://purl.obolibrary.org/obo/MP_0005205 abnormal eye anterior chamber morphology http://purl.obolibrary.org/obo/MP_0005193 abnormal anterior eye segment morphology any structural anomaly of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens http://purl.obolibrary.org/obo/MP_0005206 abnormal aqueous humor http://purl.obolibrary.org/obo/MP_0005205 abnormal eye anterior chamber morphology anomaly in the clear, watery fluid that fills the anterior and posterior chambers of the eye http://purl.obolibrary.org/obo/MP_0005207 abnormal aqueous vein morphology http://purl.obolibrary.org/obo/MP_0004221 abnormal iridocorneal angle any structural anomaly of this vessel that receives aqueous humor from the sinus venosus sclerae (canal of Schlemm) http://purl.obolibrary.org/obo/MP_0005208 abnormal iris stroma morphology http://purl.obolibrary.org/obo/MP_0001322 abnormal iris morphology any structural anomaly of the lamellated vascular connective tissue of the iris http://purl.obolibrary.org/obo/MP_0005210 disorganized stomach mucosa http://purl.obolibrary.org/obo/MP_0010792 abnormal stomach mucosa morphology derangement of the pattern of the mucous layer of the stomach wall http://purl.obolibrary.org/obo/MP_0005211 increased stomach mucosa thickness http://purl.obolibrary.org/obo/MP_0010799 stomach mucosa hyperplasia greater than the normal depth or width of the of the mucous layer of the stomach wall http://purl.obolibrary.org/obo/MP_0005213 gastric metaplasia http://purl.obolibrary.org/obo/MP_0000470 abnormal stomach morphology condition in which there is a change of one adult cell type to another adult cell type in the stomach http://purl.obolibrary.org/obo/MP_0005214 regional gastric metaplasia http://purl.obolibrary.org/obo/MP_0005213 gastric metaplasia localized areas of the stomach in which there is a change from one adult cell type to another adult cell type http://purl.obolibrary.org/obo/MP_0005215 abnormal pancreatic islet morphology http://purl.obolibrary.org/obo/MP_0009165 abnormal endocrine pancreas morphology any structural anomaly of the clusters of hormone-producing cells that are scattered throughout the pancreas http://purl.obolibrary.org/obo/MP_0005216 abnormal pancreatic alpha cell morphology http://purl.obolibrary.org/obo/MP_0005215 abnormal pancreatic islet morphology any structural anomaly of the cells of the pancreas that secrete glucagon http://purl.obolibrary.org/obo/MP_0005218 abnormal pancreatic delta cell morphology http://purl.obolibrary.org/obo/MP_0005215 abnormal pancreatic islet morphology any structural anomaly of the cells found in the pancreas that secrete somatostatin http://purl.obolibrary.org/obo/MP_0005222 abnormal somite size http://purl.obolibrary.org/obo/MP_0001688 abnormal somite development atypical size of any of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo http://purl.obolibrary.org/obo/MP_0005223 abnormal dorsal-ventral polarity of the somites http://purl.obolibrary.org/obo/MP_0001688 abnormal somite development anomalous development or formation of the pattern of somites along the axis that runs from the front (ventral) to the back (dorsal) surface of the body http://purl.obolibrary.org/obo/MP_0005224 abnormal left-right axis symmetry of the somites http://purl.obolibrary.org/obo/MP_0001706 abnormal left-right axis patterning anomaly in the formation or development of the somites in relation to the left and right sides of the body http://purl.obolibrary.org/obo/MP_0005225 abnormal vertebrae development http://purl.obolibrary.org/obo/MP_0002113 abnormal skeleton development anomalous formation of the vertebrae from the sclerotome http://purl.obolibrary.org/obo/MP_0005226 abnormal vertebral arch development http://purl.obolibrary.org/obo/MP_0005225 abnormal vertebrae development anomalous formation of the posterior projection from the body of a vertebra that encloses the vertebral foramen http://purl.obolibrary.org/obo/MP_0005227 abnormal vertebral body development http://purl.obolibrary.org/obo/MP_0005225 abnormal vertebrae development anomalous formation of the main portion of the vertebra anterior to the vertebral canal, and distinct from the vertebral arch http://purl.obolibrary.org/obo/MP_0005229 abnormal intervertebral disk development http://purl.obolibrary.org/obo/MP_0005225 abnormal vertebrae development any anomaly in the formation of the cartilaginous and gelatinous structure found between vertebrae http://purl.obolibrary.org/obo/MP_0005230 ectrodactyly http://purl.obolibrary.org/obo/MP_0002110 abnormal digit morphology absence of the middle rays, i.e., the central digits; usually associated with cleft hands/feet and may also include syndactyly or aplasia of remaining digits http://purl.obolibrary.org/obo/MP_0005231 abnormal brachial lymph node morphology http://purl.obolibrary.org/obo/MP_0008463 abnormal peripheral lymph node morphology any structural anomaly of the lymph nodes located along the brachial vein that receive drainage from most of the free upper limb and send efferent vessels to the central axillary lymph nodes http://purl.obolibrary.org/obo/MP_0005232 abnormal mesenteric lymph node morphology http://purl.obolibrary.org/obo/MP_0009625 abnormal abdominal lymph node morphology any structural anomaly of the lymph nodes located in the mesentery, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group http://purl.obolibrary.org/obo/MP_0005236 abnormal olfactory nerve morphology http://purl.obolibrary.org/obo/MP_0001056 abnormal cranial nerve morphology any structural anomaly of the first cranial nerve, which conveys the sense of smell http://purl.obolibrary.org/obo/MP_0005237 abnormal olfactory tract morphology http://purl.obolibrary.org/obo/MP_0005267 abnormal olfactory cortex morphology any structural anomaly of the nerve-like, white band composed primarily of nerve fibers originating from the mitral cells and tufted cells of the olfactory bulb, but also containing the scattered cells of the anterior olfactory nucleus http://purl.obolibrary.org/obo/MP_0005239 abnormal Bruch membrane morphology http://purl.obolibrary.org/obo/MP_0005098 abnormal optic choroid morphology any structural anomaly of the transparent, nearly structureless inner layer of the choroid in contact with the pigmented layer of the retina http://purl.obolibrary.org/obo/MP_0005240 abnormal amacrine cell morphology http://purl.obolibrary.org/obo/MP_0001325 abnormal retina morphology any structural anomaly of one of the three types of interneurons found in the inner nuclear layer of the mature retina; they integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer http://purl.obolibrary.org/obo/MP_0005241 abnormal retinal ganglion layer morphology http://purl.obolibrary.org/obo/MP_0006069 abnormal retinal neuronal layer morphology any structural anomaly of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain http://purl.obolibrary.org/obo/MP_0005242 cryptophthalmos http://purl.obolibrary.org/obo/MP_0001341 absent eyelids congenital anomaly in which the skin is continuous over the eyeball without any indication of the formation of eyelids http://purl.obolibrary.org/obo/MP_0005243 hemothorax http://purl.obolibrary.org/obo/MP_0002295 abnormal pulmonary circulation bleeding into the pleural space http://purl.obolibrary.org/obo/MP_0005244 hemopericardium http://purl.obolibrary.org/obo/MP_0009698 heart hemorrhage bleeding into the pericardial space http://purl.obolibrary.org/obo/MP_0005245 hemarthrosis http://purl.obolibrary.org/obo/MP_0002932 abnormal joint morphology bleeding into a joint space http://purl.obolibrary.org/obo/MP_0005247 abnormal extraocular muscle morphology http://purl.obolibrary.org/obo/MP_0003686 abnormal eye muscle morphology any structural anomaly of any of the striated muscles that move the eye and include: superior rectus, inferior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi http://purl.obolibrary.org/obo/MP_0005249 abnormal palatine bone morphology http://purl.obolibrary.org/obo/MP_0005274 abnormal viscerocranium morphology any structural anomaly of either of two irregularly L-shaped bones located posterior to the maxilla that in part forms the back of the hard palate, part of the nasal cavity and part of the floor of the orbits http://purl.obolibrary.org/obo/MP_0005250 Sertoli cell hypoplasia http://purl.obolibrary.org/obo/MP_0002784 abnormal Sertoli cell morphology decreased number of cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis http://purl.obolibrary.org/obo/MP_0005251 blepharitis http://purl.obolibrary.org/obo/MP_0001851 eye inflammation inflammation of the eyelids http://purl.obolibrary.org/obo/MP_0005254 strabismus http://purl.obolibrary.org/obo/MP_0002092 abnormal eye morphology misalignment of the visual axes of the eyes http://purl.obolibrary.org/obo/MP_0005255 exotropia http://purl.obolibrary.org/obo/MP_0005254 strabismus a form of ocular misalignment in which the lateral rectus muscle pulls the eye in an outward direction http://purl.obolibrary.org/obo/MP_0005256 esotropia http://purl.obolibrary.org/obo/MP_0005254 strabismus a form of ocular misalignment in which there is excessive convergence of the visual axes, giving a cross-eyed appearance http://purl.obolibrary.org/obo/MP_0005257 abnormal intraocular pressure http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology anomaly in the amount of force per unit area exerted by the intraocular fluid within the eye http://purl.obolibrary.org/obo/MP_0005258 ocular hypertension http://purl.obolibrary.org/obo/MP_0005257 abnormal intraocular pressure abnormal elevation of the intraocular pressure http://purl.obolibrary.org/obo/MP_0005260 ocular hypotension http://purl.obolibrary.org/obo/MP_0005257 abnormal intraocular pressure abnormally low intraocular pressure http://purl.obolibrary.org/obo/MP_0005261 aniridia http://purl.obolibrary.org/obo/MP_0001322 abnormal iris morphology abnormality in which there is only a rudimentary iris, due to the failure of optic cup growth http://purl.obolibrary.org/obo/MP_0005262 coloboma http://purl.obolibrary.org/obo/MP_0001286 abnormal eye development anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation http://purl.obolibrary.org/obo/MP_0005263 ectopia lentis http://purl.obolibrary.org/obo/MP_0001303 abnormal lens morphology congenital displacement of the lens due to defective zonule formation http://purl.obolibrary.org/obo/MP_0005264 glomerulosclerosis http://purl.obolibrary.org/obo/MP_0000523 cortical renal glomerulopathies hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes http://purl.obolibrary.org/obo/MP_0005265 abnormal blood urea nitrogen level http://purl.obolibrary.org/obo/MP_0009642 abnormal blood homeostasis aberrant circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function http://purl.obolibrary.org/obo/MP_0005267 abnormal olfactory cortex morphology http://purl.obolibrary.org/obo/MP_0009944 abnormal olfactory lobe morphology any structural anomaly of cortex area which receives its major afferents from the olfactory bulb, and is primarily responsible for the identification of odors http://purl.obolibrary.org/obo/MP_0005270 abnormal zygomatic bone morphology http://purl.obolibrary.org/obo/MP_0005274 abnormal viscerocranium morphology any structural anomaly of the quadrilateral bone that forms the prominence of the cheek http://purl.obolibrary.org/obo/MP_0005271 abnormal lacrimal bone morphology http://purl.obolibrary.org/obo/MP_0005274 abnormal viscerocranium morphology any structural anomaly of the irregularly thin plate that forms part of the medial wall of the orbit behind the frontal process of the maxilla http://purl.obolibrary.org/obo/MP_0005272 abnormal temporal bone morphology http://purl.obolibrary.org/obo/MP_0000074 abnormal neurocranium morphology any structural anomaly of the large, irregular bone located at the base and side of the skull; consists of three parts at birth: squamous, tympanic, and petrous http://purl.obolibrary.org/obo/MP_0005279 narcolepsy http://purl.obolibrary.org/obo/MP_0001501 abnormal sleep pattern recurring episodes of sleep during normal waking hours and often disrupted sleep during normal sleeping period; often accompanied by cataplexy, sleep paralysis and hallucinations http://purl.obolibrary.org/obo/MP_0005280 abnormal fatty acid level http://purl.obolibrary.org/obo/MP_0001547 abnormal lipid level any anomaly in the concentration of aliphatic monocarboxylic acids derived from or contained in esterified form in an animal or vegetable fat, oil or wax; natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated http://purl.obolibrary.org/obo/MP_0005283 increased unsaturated fatty acid level http://purl.obolibrary.org/obo/MP_0005281 increased fatty acid level elevated concentration of unsaturated aliphatic monocarboxylic acids derived from or contained in esterified form in an animal or vegetable fat, oil or wax; unsaturated fatty acids commonly have a chain of 4 to 28 carbons which possess one or more double or triple bonds between carbon atoms http://purl.obolibrary.org/obo/MP_0005284 increased saturated fatty acid level http://purl.obolibrary.org/obo/MP_0005281 increased fatty acid level elevated concentration of saturated aliphatic monocarboxylic acids derived from or contained in esterified form in an animal or vegetable fat, oil or wax; saturated fatty acids commonly have a chain of 4 to 28 carbons which contains no ethylenic or other unsaturated linkages between carbon atoms http://purl.obolibrary.org/obo/MP_0005285 decreased unsaturated fatty acid level http://purl.obolibrary.org/obo/MP_0005282 decreased fatty acid level reduced concentration of unsaturated aliphatic monocarboxylic acids derived from or contained in esterified form in an animal or vegetable fat, oil or wax; unsaturated fatty acids commonly have a chain of 4 to 28 carbons which possess one or more double or triple bonds between carbon atoms http://purl.obolibrary.org/obo/MP_0005286 decreased saturated fatty acid level http://purl.obolibrary.org/obo/MP_0005282 decreased fatty acid level reduced concentration of saturated aliphatic monocarboxylic acids derived from or contained in esterified form in an animal or vegetable fat, oil or wax; saturated fatty acids commonly have a chain of 4 to 28 carbons which contains no ethylenic or other unsaturated linkages between carbon atoms http://purl.obolibrary.org/obo/MP_0005287 narrow eye opening http://purl.obolibrary.org/obo/MP_0003671 abnormal eyelid aperture less than the normal distance from one eyelid to the other without fusion of the eyelid margins http://purl.obolibrary.org/obo/MP_0005288 abnormal oxygen consumption http://purl.obolibrary.org/obo/MP_0003948 abnormal gas homeostasis deviation from the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body http://purl.obolibrary.org/obo/MP_0005289 increased oxygen consumption http://purl.obolibrary.org/obo/MP_0005288 abnormal oxygen consumption greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body http://purl.obolibrary.org/obo/MP_0005290 decreased oxygen consumption http://purl.obolibrary.org/obo/MP_0005288 abnormal oxygen consumption less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body http://purl.obolibrary.org/obo/MP_0005291 abnormal glucose tolerance http://purl.obolibrary.org/obo/MP_0002078 abnormal glucose homeostasis deviation from the normal response to oral consumption or intravenous injection of specified amounts of glucose; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals http://purl.obolibrary.org/obo/MP_0005292 improved glucose tolerance http://purl.obolibrary.org/obo/MP_0005291 abnormal glucose tolerance better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals http://purl.obolibrary.org/obo/MP_0005293 impaired glucose tolerance http://purl.obolibrary.org/obo/MP_0005291 abnormal glucose tolerance less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals http://purl.obolibrary.org/obo/MP_0005296 abnormal humerus morphology http://purl.obolibrary.org/obo/MP_0011504 abnormal limb long bone morphology any structural anomaly of the bone of the forelimb that articulates with the scapula above and the radius and ulna below http://purl.obolibrary.org/obo/MP_0005297 spina bifida occulta http://purl.obolibrary.org/obo/MP_0005226 abnormal vertebral arch development defective closure of the laminae of the vertebral column in the lumbosacral region without hernial protrusion of the spinal cord or meninges; the mildest, most common and often asymptomatic form of spina bifida, identified externally by a skin depression or dimple, dark tufts of hair, telangiectasis, or soft subcutaneous lipomas at the site of defect http://purl.obolibrary.org/obo/MP_0005299 abnormal eye posterior chamber morphology http://purl.obolibrary.org/obo/MP_0005193 abnormal anterior eye segment morphology any structural anomaly of the ring-like space, filled with aqueous humor, between the iris/pupil anteriorly and the lens and ciliary body posteriorly http://purl.obolibrary.org/obo/MP_0005302 neurogenic bladder http://purl.obolibrary.org/obo/MP_0010386 abnormal urinary bladder physiology defective functioning of the bladder due to impaired innervation, either within the CNS or the PNS http://purl.obolibrary.org/obo/MP_0005304 cystic bulbourethral gland http://purl.obolibrary.org/obo/MP_0001169 abnormal bulbourethral gland morphology presence of membrane-lined sacs containing gas, fluid, or semisolid matter in the gland in males that lies along the prostate gland and secretes a fluid component of the seminal fluid into the urethra http://purl.obolibrary.org/obo/MP_0005305 prostate gland anterior lobe hyperplasia http://purl.obolibrary.org/obo/MP_0001163 abnormal prostate gland anterior lobe morphology overdevelopment or increased size, usually due an increased number of cells in the anterior lobe of the prostate http://purl.obolibrary.org/obo/MP_0005307 head tossing http://purl.obolibrary.org/obo/MP_0001408 stereotypic behavior repetitive flailing of the head in multiple directions http://purl.obolibrary.org/obo/MP_0005308 abnormal circulating ammonia level http://purl.obolibrary.org/obo/MP_0009642 abnormal blood homeostasis aberrant amount of ammonia or its compounds in blood, formed in the body during organic decomposition http://purl.obolibrary.org/obo/MP_0005309 increased circulating ammonia level http://purl.obolibrary.org/obo/MP_0005308 abnormal circulating ammonia level significantly elevated levels of ammonia or its compounds in blood; often associated with liver failure and hepatic encephalopathy http://purl.obolibrary.org/obo/MP_0005312 pericardial effusion http://purl.obolibrary.org/obo/MP_0001784 abnormal fluid regulation escape of fluid from blood vessels or lymphatic vessels into the fibrous sac surrounding the heart http://purl.obolibrary.org/obo/MP_0005313 absent adrenal gland http://purl.obolibrary.org/obo/MP_0000639 abnormal adrenal gland morphology absence of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla http://purl.obolibrary.org/obo/MP_0005314 absent thyroid gland http://purl.obolibrary.org/obo/MP_0004663 athyroidism lack of the endocrine gland that is normally located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin http://purl.obolibrary.org/obo/MP_0005315 absent pituitary gland http://purl.obolibrary.org/obo/MP_0000633 abnormal pituitary gland morphology lack of the gland that is normally suspended from the base of the hypothalamus and which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin http://purl.obolibrary.org/obo/MP_0005320 abnormal biopterin level http://purl.obolibrary.org/obo/MP_0005319 abnormal enzyme/ coenzyme level anomaly in the concentration of this pterin found in yeast, the fruit fly and in normal human urine, the reduced form of which acts as a coenzyme for many enzymatic reactions http://purl.obolibrary.org/obo/MP_0005321 abnormal neopterin level http://purl.obolibrary.org/obo/MP_0005320 abnormal biopterin level anomaly in the concentration of a pteridine derivative, which is present in body fluids and is a precursor in the biosynthesis of biopterin; elevated levels result from immune activation, malignant disease, allograft rejection, and viral infection http://purl.obolibrary.org/obo/MP_0005322 abnormal serotonin level http://purl.obolibrary.org/obo/MP_0003953 abnormal hormone level anomaly in the amount of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity http://purl.obolibrary.org/obo/MP_0005323 dystonia http://purl.obolibrary.org/obo/MP_0004142 abnormal muscle tone impairment of muscle tone resulting in prolonged muscle contraction and involuntary movements such as repetitive movements, or twisting or writhing of the limbs http://purl.obolibrary.org/obo/MP_0005324 ascites http://purl.obolibrary.org/obo/MP_0001784 abnormal fluid regulation accumulation or retention of fluid within the peritoneal cavity http://purl.obolibrary.org/obo/MP_0005326 abnormal podocyte morphology http://purl.obolibrary.org/obo/MP_0011497 abnormal glomerular capsule visceral layer morphology any structural anomaly of a modified epithelial cell of the visceral layer of the Bowman capsule in the renal corpuscle; it has a small perikaryon and a number of primary and secondary foot processes that interdigitate with those of other podocytes and are attached to the outer surface of the glomerular capillary basement membrane http://purl.obolibrary.org/obo/MP_0005327 abnormal mesangial cell morphology http://purl.obolibrary.org/obo/MP_0011339 abnormal glomerular mesangium morphology any structural anomaly of the modified smooth muscle cells that are interposed between endothelial cells and the basement membrane in the central or stalk region of the capillary tuft of the renal glomerulus, which regulate blood flow by their contractile activity, and secrete extracellular matrix, prostaglandins, and cytokines; mesangial cells also have phagocytic activity, removing proteins and other molecules trapped in the glomerular basement membrane or filtration barrier http://purl.obolibrary.org/obo/MP_0005328 abnormal circulating creatinine level http://purl.obolibrary.org/obo/MP_0005311 abnormal circulating amino acid level anomaly in the blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction http://purl.obolibrary.org/obo/MP_0005331 insulin resistance http://purl.obolibrary.org/obo/MP_0002078 abnormal glucose homeostasis diminished effectiveness of insulin in lowering plasma glucose levels http://purl.obolibrary.org/obo/MP_0005332 abnormal amino acid level http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis any anomaly in the amount of a carboxylic acid containing one or more amino groups (-NH2) and a carboxyl (-COOH) group http://purl.obolibrary.org/obo/MP_0005333 decreased heart rate http://purl.obolibrary.org/obo/MP_0001629 abnormal heart rate fewer than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute http://purl.obolibrary.org/obo/MP_0005335 abnormal gonadal fat pad morphology http://purl.obolibrary.org/obo/MP_0000010 abnormal abdominal fat pad morphology any structural anomaly of the encapsulated adipose tissue associated with the ovaries or testes http://purl.obolibrary.org/obo/MP_0005336 abnormal inguinal fat pad morphology http://purl.obolibrary.org/obo/MP_0000010 abnormal abdominal fat pad morphology any structural anomaly of the encapsulated adipose tissue found in the groin http://purl.obolibrary.org/obo/MP_0005337 abnormal retroperitoneal fat pad morphology http://purl.obolibrary.org/obo/MP_0000010 abnormal abdominal fat pad morphology any structural anomaly of the encapsulated adipose tissue found on the dorsal side of the peritoneum http://purl.obolibrary.org/obo/MP_0005338 atherosclerotic lesions http://purl.obolibrary.org/obo/MP_0003991 arteriosclerosis thickening and loss of elasticity of arterial walls, involving plaque-like lipid deposition and thickening of intimal layers within arteries; progresses to narrowing of arterial lumens with fibrosis and calcification resulting in restriction of blood flow http://purl.obolibrary.org/obo/MP_0005339 increased susceptibility to atherosclerosis http://purl.obolibrary.org/obo/MP_0005340 altered susceptibility to atherosclerosis more likely than normal to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries http://purl.obolibrary.org/obo/MP_0005340 altered susceptibility to atherosclerosis http://purl.obolibrary.org/obo/MP_0005338 atherosclerotic lesions a change in the likelihood that an organism will develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries http://purl.obolibrary.org/obo/MP_0005341 decreased susceptibility to atherosclerosis http://purl.obolibrary.org/obo/MP_0005340 altered susceptibility to atherosclerosis less likely than normal to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries http://purl.obolibrary.org/obo/MP_0005343 increased circulating aspartate transaminase level http://purl.obolibrary.org/obo/MP_0000203 abnormal circulating aspartate transaminase level greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction http://purl.obolibrary.org/obo/MP_0005344 increased circulating bilirubin level http://purl.obolibrary.org/obo/MP_0001569 abnormal circulating bilirubin level increased concentration in the blood of the bile pigment bilirubin, normally found in the liver and in red blood cells http://purl.obolibrary.org/obo/MP_0005348 increased T cell proliferation http://purl.obolibrary.org/obo/MP_0005094 abnormal T cell proliferation increase in the ability of a naive T cell population to undergo rapid expansion by cell division in response to stimuli http://purl.obolibrary.org/obo/MP_0005352 small cranium http://purl.obolibrary.org/obo/MP_0010031 abnormal cranium size reduced size of the cranium http://purl.obolibrary.org/obo/MP_0005353 abnormal patella morphology http://purl.obolibrary.org/obo/MP_0002115 abnormal limb bone morphology any structural anomaly of the large sesamoid bone that covers the anterior surface of the knee http://purl.obolibrary.org/obo/MP_0005354 abnormal ilium morphology http://purl.obolibrary.org/obo/MP_0004509 abnormal pelvic girdle bone morphology any structural anomaly of the broad, flaring portion of the hip bone, which is distinct at birth, but later fuses with the ischium and the pubis http://purl.obolibrary.org/obo/MP_0005356 positive geotaxis http://purl.obolibrary.org/obo/MP_0003313 abnormal locomotor activation mice, when placed on a downward on a slanting grid, walk down without turning around, or exhibit a delay in turning around, whereas wild type mice will always turn around and walk upward http://purl.obolibrary.org/obo/MP_0005357 novel environmental response-related retropulsion http://purl.obolibrary.org/obo/MP_0010323 retropulsion when confronted with a novel stimulus, subjects exhibit involuntary backward walking http://purl.obolibrary.org/obo/MP_0005359 growth retardation of incisors http://purl.obolibrary.org/obo/MP_0000116 abnormal tooth development developmental delay of the growth of the incisors, the long pointed teeth, most anterior and prominent in the jaw http://purl.obolibrary.org/obo/MP_0005363 decreased susceptibility to prion infection http://purl.obolibrary.org/obo/MP_0020187 altered susceptibility to prion infection reduced likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is a major and necessary component http://purl.obolibrary.org/obo/MP_0005364 increased susceptibility to prion infection http://purl.obolibrary.org/obo/MP_0020187 altered susceptibility to prion infection increased likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is a major and necessary component http://purl.obolibrary.org/obo/MP_0005365 abnormal bile salt homeostasis http://purl.obolibrary.org/obo/MP_0002118 abnormal lipid homeostasis anomaly in the processes involved in the maintenance of an internal equilibrium of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary system as bile salts; these play an important role in the digestion and absorption of fats http://purl.obolibrary.org/obo/MP_0005386 behavior/neurological phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype the observable actions or reactions of mammalian organisms that are manifested through development and lifespan http://purl.obolibrary.org/obo/MP_0005398 decreased susceptibility to fungal infection http://purl.obolibrary.org/obo/MP_0020183 altered susceptibility to fungal infection reduced likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms http://purl.obolibrary.org/obo/MP_0005399 increased susceptibility to fungal infection http://purl.obolibrary.org/obo/MP_0020183 altered susceptibility to fungal infection greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms http://purl.obolibrary.org/obo/MP_0005400 abnormal vitamin level http://purl.obolibrary.org/obo/MP_0004019 abnormal vitamin homeostasis any anomaly in the concentration of any of the organic substances found in food that are necessary in trace amounts for normal metabolic function http://purl.obolibrary.org/obo/MP_0005401 abnormal fat-soluble vitamin level http://purl.obolibrary.org/obo/MP_0005400 abnormal vitamin level any anomaly in the concentration of any of the organic substances found in food that are necessary in trace amounts for normal metabolic function and which require the presence of lipids for assimilation in the body http://purl.obolibrary.org/obo/MP_0005403 abnormal nerve conduction http://purl.obolibrary.org/obo/MP_0002272 abnormal nervous system electrophysiology anomaly in the act of transmitting electricity along a single nerve http://purl.obolibrary.org/obo/MP_0005408 hypopigmentation http://purl.obolibrary.org/obo/MP_0001186 pigmentation phenotype dilution of pigment in any or all tissues or a part of a tissue http://purl.obolibrary.org/obo/MP_0005409 darkened coat color http://purl.obolibrary.org/obo/MP_0012076 abnormal agouti pigmentation amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreased when compared to wild-type agouti http://purl.obolibrary.org/obo/MP_0005411 delayed fertilization http://purl.obolibrary.org/obo/MP_0005410 abnormal fertilization a lag in the normal time of onset of the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronuclei http://purl.obolibrary.org/obo/MP_0005412 vascular stenosis http://purl.obolibrary.org/obo/MP_0001614 abnormal blood vessel morphology a stricture or occlusion of a lumen of vascular tissue http://purl.obolibrary.org/obo/MP_0005413 vascular restenosis http://purl.obolibrary.org/obo/MP_0005412 vascular stenosis recurrence of a narrowing or constriction of a blood vessel following surgical or mechanical removal or reduction of a previous narrowing http://purl.obolibrary.org/obo/MP_0005414 extrahepatic cholestasis http://purl.obolibrary.org/obo/MP_0000610 cholestasis impairment of bile flow in the large bile ducts by mechanical obstruction or stricture due to benign or malignant process http://purl.obolibrary.org/obo/MP_0005415 intrahepatic cholestasis http://purl.obolibrary.org/obo/MP_0000610 cholestasis impairment of bile flow due to injury to the hepatocytes, bile canaliculi, or the intrahepatic bile ducts http://purl.obolibrary.org/obo/MP_0005419 decreased circulating serum albumin level http://purl.obolibrary.org/obo/MP_0000199 abnormal circulating serum albumin level blood serum albumin concentration below the normal range http://purl.obolibrary.org/obo/MP_0005421 loose skin http://purl.obolibrary.org/obo/MP_0009931 abnormal skin appearance condition in which the skin hangs in folds http://purl.obolibrary.org/obo/MP_0005422 osteosclerosis http://purl.obolibrary.org/obo/MP_0003795 abnormal bone structure abnormal hardening or eburnation (change in exposed subchondral bone in degenerative joint disease in which bone is converted into a dense substance with a smooth surface) of bone http://purl.obolibrary.org/obo/MP_0005423 abnormal somatic nervous system physiology http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology any functional anomaly of the part of the peripheral nervous system that is responsible for conveying voluntary motor and external sensory information, including all nerves controlling the skeletal muscular system and external sensory receptors (including balance, smell, sight, taste, touch and hearing sensory inputs) http://purl.obolibrary.org/obo/MP_0005424 jerky movement http://purl.obolibrary.org/obo/MP_0001516 abnormal motor coordination/ balance continuous, abrupt, faltering motions of the whole body or a portion of the body http://purl.obolibrary.org/obo/MP_0005425 increased macrophage cell number http://purl.obolibrary.org/obo/MP_0020202 abnormal macrophage cell number greater than the normal numbers of macrophages http://purl.obolibrary.org/obo/MP_0005426 tachypnea http://purl.obolibrary.org/obo/MP_0005573 increased pulmonary respiratory rate rapid breathing http://purl.obolibrary.org/obo/MP_0005430 absent fibula http://purl.obolibrary.org/obo/MP_0002187 abnormal fibula morphology absence of the lateral and shorter of the two bones of the lower leg http://purl.obolibrary.org/obo/MP_0005431 decreased oocyte number http://purl.obolibrary.org/obo/MP_0020152 abnormal oocyte number reduced numbers of germ cells in the female http://purl.obolibrary.org/obo/MP_0005432 abnormal pro-B cell morphology http://purl.obolibrary.org/obo/MP_0002144 abnormal B cell differentiation any structural anomaly of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs http://purl.obolibrary.org/obo/MP_0005433 absent early pro-B cells http://purl.obolibrary.org/obo/MP_0008187 absent pro-B cells absence of cells in the B lymphocyte lineage that undergo D-J rearrangement of the immunoglobulin heavy chain http://purl.obolibrary.org/obo/MP_0005434 absent late pro-B cells http://purl.obolibrary.org/obo/MP_0008187 absent pro-B cells absence of the cells in the B lymphocyte lineage that undergo V-DJ rearrangement of the immunoglobulin heavy chain http://purl.obolibrary.org/obo/MP_0005435 hemoperitoneum http://purl.obolibrary.org/obo/MP_0001634 internal hemorrhage blood in the peritoneal cavity http://purl.obolibrary.org/obo/MP_0005437 abnormal glycogen level http://purl.obolibrary.org/obo/MP_0005438 abnormal glycogen homeostasis any anomaly in the concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle http://purl.obolibrary.org/obo/MP_0005439 decreased glycogen level http://purl.obolibrary.org/obo/MP_0005437 abnormal glycogen level less than the normal concentration of a readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle http://purl.obolibrary.org/obo/MP_0005440 increased glycogen level http://purl.obolibrary.org/obo/MP_0005437 abnormal glycogen level greater than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle http://purl.obolibrary.org/obo/MP_0005441 increased urine calcium level http://purl.obolibrary.org/obo/MP_0002985 abnormal urine calcium level abnormally large amounts of calcium in the urine http://purl.obolibrary.org/obo/MP_0005443 abnormal ethanol metabolism http://purl.obolibrary.org/obo/MP_0008875 abnormal xenobiotic pharmacokinetics altered ability to metabolize the clear, colorless liquid that has formula C2H6O http://purl.obolibrary.org/obo/MP_0005444 abnormal retinol metabolism http://purl.obolibrary.org/obo/MP_0011233 abnormal vitamin A metabolism altered ability to metabolize retinol, which plays an essential role in metabolic functioning of the retina, and growth of and differentiation http://purl.obolibrary.org/obo/MP_0005446 abnormal synaptic epinephrine release http://purl.obolibrary.org/obo/MP_0005445 abnormal neurotransmitter secretion aberrant secretion across synapses of the active sympathomimetic hormone that stimulates both the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels http://purl.obolibrary.org/obo/MP_0005447 abnormal synaptic norepinephrine release http://purl.obolibrary.org/obo/MP_0005445 abnormal neurotransmitter secretion aberrant secretion across synapses of this widespread central and autonomic neurotransmitter, the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus http://purl.obolibrary.org/obo/MP_0005448 abnormal energy homeostasis http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis any anomaly in the process involved in the balance between food intake (energy input) and energy expenditure http://purl.obolibrary.org/obo/MP_0005450 abnormal energy expenditure http://purl.obolibrary.org/obo/MP_0005448 abnormal energy homeostasis utilization of calories that differs from normal http://purl.obolibrary.org/obo/MP_0005457 abnormal percent body fat http://purl.obolibrary.org/obo/MP_0012320 abnormal body fat mass more or less fat, relative to controls, as a percentage of total body weight http://purl.obolibrary.org/obo/MP_0005458 increased percent body fat http://purl.obolibrary.org/obo/MP_0005457 abnormal percent body fat more fat, relative to controls, as a percentage of total body weight http://purl.obolibrary.org/obo/MP_0005459 decreased percent body fat http://purl.obolibrary.org/obo/MP_0005457 abnormal percent body fat less fat, relative to controls, as a percentage of total body weight http://purl.obolibrary.org/obo/MP_0005462 abnormal mast cell differentiation http://purl.obolibrary.org/obo/MP_0008111 abnormal granulocyte differentiation atypical production of or inability to produce a cell that is found in almost all tissues, containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation http://purl.obolibrary.org/obo/MP_0005463 abnormal CD4-positive, alpha-beta T cell physiology http://purl.obolibrary.org/obo/MP_0002444 abnormal T cell physiology any functional anomaly of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production http://purl.obolibrary.org/obo/MP_0005464 abnormal platelet physiology http://purl.obolibrary.org/obo/MP_0012382 abnormal blood cell physiology any functional anomaly of the non-nucleated cells found in the blood and involved in blood coagulation http://purl.obolibrary.org/obo/MP_0005465 abnormal T-helper 1 physiology http://purl.obolibrary.org/obo/MP_0005463 abnormal CD4-positive, alpha-beta T cell physiology abnormal function of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity http://purl.obolibrary.org/obo/MP_0005466 abnormal T-helper 2 physiology http://purl.obolibrary.org/obo/MP_0005463 abnormal CD4-positive, alpha-beta T cell physiology abnormal function of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy http://purl.obolibrary.org/obo/MP_0005469 abnormal thyroxine level http://purl.obolibrary.org/obo/MP_0005468 abnormal thyroid hormone level any anomaly in the concentration of the major hormone derived from the thyroid gland; it normally affects cellular metabolism http://purl.obolibrary.org/obo/MP_0005470 increased thyroxine level http://purl.obolibrary.org/obo/MP_0005469 abnormal thyroxine level greater than the normal concentration of the major hormone derived from the thyroid gland; it normally affects cellular metabolism http://purl.obolibrary.org/obo/MP_0005471 decreased thyroxine level http://purl.obolibrary.org/obo/MP_0005469 abnormal thyroxine level less than the normal concentration of the major hormone derived from the thyroid gland; it normally affects cellular metabolism http://purl.obolibrary.org/obo/MP_0005472 abnormal triiodothyronine level http://purl.obolibrary.org/obo/MP_0005468 abnormal thyroid hormone level aberrant concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues http://purl.obolibrary.org/obo/MP_0005473 decreased triiodothyronine level http://purl.obolibrary.org/obo/MP_0005472 abnormal triiodothyronine level less than the normal concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues http://purl.obolibrary.org/obo/MP_0005474 increased triiodothyronine level http://purl.obolibrary.org/obo/MP_0005472 abnormal triiodothyronine level greater than the normal concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues http://purl.obolibrary.org/obo/MP_0005475 abnormal circulating thyroxine level http://purl.obolibrary.org/obo/MP_0005469 abnormal thyroxine level anomaly in the blood concentration of the major hormone derived from the thyroid gland that normally affects cellular metabolism http://purl.obolibrary.org/obo/MP_0005476 abnormal circulating triiodothyronine level http://purl.obolibrary.org/obo/MP_0005472 abnormal triiodothyronine level aberration in the blood concentration of a hormone synthesized and secreted by the thyroid that is the main thyroid hormone used by the tissues http://purl.obolibrary.org/obo/MP_0005477 increased circulating thyroxine level http://purl.obolibrary.org/obo/MP_0005475 abnormal circulating thyroxine level greater than the normal blood concentration of the major hormone derived from the thyroid gland that normally affects cellular metabolism http://purl.obolibrary.org/obo/MP_0005478 decreased circulating thyroxine level http://purl.obolibrary.org/obo/MP_0005475 abnormal circulating thyroxine level reduction in the normal blood concentration of the major hormone derived from the thyroid gland that normally affects cellular metabolism http://purl.obolibrary.org/obo/MP_0005479 decreased circulating triiodothyronine level http://purl.obolibrary.org/obo/MP_0005476 abnormal circulating triiodothyronine level less than the normal blood concentration of a hormone synthesized and secreted by the thyroid that is the main thyroid hormone used by the tissues http://purl.obolibrary.org/obo/MP_0005480 increased circulating triiodothyronine level http://purl.obolibrary.org/obo/MP_0005476 abnormal circulating triiodothyronine level greater than the normal blood concentration of a hormone synthesized and secreted by the thyroid that is the main thyroid hormone used by the tissues http://purl.obolibrary.org/obo/MP_0005481 increased chronic myelocytic leukemia incidence http://purl.obolibrary.org/obo/MP_0002026 increased leukemia incidence higher than normal incidence of a heterogeneous group of myeloproliferative disorders that may evolve into acute leukemia in late stages http://purl.obolibrary.org/obo/MP_0005488 bronchial epithelial hyperplasia http://purl.obolibrary.org/obo/MP_0010943 abnormal bronchus epithelium morphology increased numbers of cells lining the inner surfaces of the bronchi http://purl.obolibrary.org/obo/MP_0005489 vascular smooth muscle cell hyperplasia http://purl.obolibrary.org/obo/MP_0005592 abnormal vascular smooth muscle morphology increased numbers of smooth muscle cells in the vascular wall http://purl.obolibrary.org/obo/MP_0005490 increased Clara cell number http://purl.obolibrary.org/obo/MP_0010809 abnormal Clara cell morphology increased numbers of the rounded, club-shaped, nonciliated cells found between ciliated cells in bronchiolar epithelium http://purl.obolibrary.org/obo/MP_0005491 pancreatic islet hyperplasia http://purl.obolibrary.org/obo/MP_0009171 enlarged pancreatic islets overdevelopment or increased size of the clusters of hormone-producing cells that are scattered throughout the pancreas, usually due an increased number of cells http://purl.obolibrary.org/obo/MP_0005492 exocrine pancreas hypoplasia http://purl.obolibrary.org/obo/MP_0009111 pancreas hypoplasia underdevelopment or reduced size of the portion of the pancreas that secretes digestive enzymes, usually due to a decreased cell number http://purl.obolibrary.org/obo/MP_0005493 stomach epithelial hyperplasia http://purl.obolibrary.org/obo/MP_0000471 abnormal stomach epithelium morphology overdevelopment or increased size, usually due to an increase in the number of cells, of the epithelial layer of the stomach http://purl.obolibrary.org/obo/MP_0005494 esophagogastric junction metaplasia http://purl.obolibrary.org/obo/MP_0005213 gastric metaplasia conversion of one differentiated cell type to another differentiated cell type at the terminal end of the esophagus and beginning of the stomach http://purl.obolibrary.org/obo/MP_0005497 optic nerve cupping http://purl.obolibrary.org/obo/MP_0001330 abnormal optic nerve morphology concave shape of the nerve often as a result of the force of pressure from glaucoma http://purl.obolibrary.org/obo/MP_0005498 hyporesponsive to tactile stimuli http://purl.obolibrary.org/obo/MP_0005316 abnormal response to tactile stimuli reduced reflex action normally induced by touch or pain http://purl.obolibrary.org/obo/MP_0005499 abnormal olfactory system morphology http://purl.obolibrary.org/obo/MP_0005394 taste/olfaction phenotype any structural anomaly of the organs involved in smell http://purl.obolibrary.org/obo/MP_0005505 increased platelet cell number http://purl.obolibrary.org/obo/MP_0011898 abnormal platelet cell number greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation http://purl.obolibrary.org/obo/MP_0005507 tail dragging http://purl.obolibrary.org/obo/MP_0001391 abnormal tail movements pulling the tail along with difficulty or effort; may be due to paralysis or weakness http://purl.obolibrary.org/obo/MP_0005515 uveitis http://purl.obolibrary.org/obo/MP_0001851 eye inflammation inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina) http://purl.obolibrary.org/obo/MP_0005516 increased liver regeneration http://purl.obolibrary.org/obo/MP_0002658 abnormal liver regeneration greater than the normal ability of liver to regenerate healthy tissue following partial hepatectomy http://purl.obolibrary.org/obo/MP_0005517 decreased liver regeneration http://purl.obolibrary.org/obo/MP_0002658 abnormal liver regeneration less than the normal ability of liver to regenerate healthy tissue following partial hepatectomy http://purl.obolibrary.org/obo/MP_0005518 abnormal pancreas regeneration http://purl.obolibrary.org/obo/MP_0002693 abnormal pancreas physiology deviation from the normal ability of the pancreas to regenerate healthy tissue following injury http://purl.obolibrary.org/obo/MP_0005519 increased pancreas regeneration http://purl.obolibrary.org/obo/MP_0005518 abnormal pancreas regeneration greater than the normal ability of the pancreas to regenerate healthy tissue following injury http://purl.obolibrary.org/obo/MP_0005520 decreased pancreas regeneration http://purl.obolibrary.org/obo/MP_0005518 abnormal pancreas regeneration less than the normal ability of the pancreas to regenerate healthy tissue following injury http://purl.obolibrary.org/obo/MP_0005521 abnormal circulating atrial natriuretic factor level http://purl.obolibrary.org/obo/MP_0005418 abnormal circulating hormone level deviation from the normal concentration of the peptide hormone in the blood that regulates the water-electrolyte balance and acts as a vasodilator http://purl.obolibrary.org/obo/MP_0005522 increased circulating atrial natriuretic factor http://purl.obolibrary.org/obo/MP_0005521 abnormal circulating atrial natriuretic factor level greater than the normal concentration of the peptide hormone in the blood that regulates the water-electrolyte balance and acts as a vasodilator http://purl.obolibrary.org/obo/MP_0005523 decreased circulating atrial natriuretic factor http://purl.obolibrary.org/obo/MP_0005521 abnormal circulating atrial natriuretic factor level less than the normal concentration of the peptide hormone in the blood that regulates the water-electrolyte balance and acts as a vasodilator http://purl.obolibrary.org/obo/MP_0005524 abnormal renal plasma flow rate http://purl.obolibrary.org/obo/MP_0002136 abnormal kidney physiology deviation from the normal volume of plasma passing through the kidney per unit time http://purl.obolibrary.org/obo/MP_0005525 increased renal plasma flow rate http://purl.obolibrary.org/obo/MP_0005524 abnormal renal plasma flow rate greater than the normal volume of plasma passing through the kidney per unit time http://purl.obolibrary.org/obo/MP_0005526 decreased renal plasma flow rate http://purl.obolibrary.org/obo/MP_0005524 abnormal renal plasma flow rate less than the normal volume of plasma passing through the kidney per unit time http://purl.obolibrary.org/obo/MP_0005527 increased renal glomerular filtration rate http://purl.obolibrary.org/obo/MP_0002847 abnormal renal glomerular filtration rate greater than the normal volume of water filtered out of the plasma through glomerular capillary walls into the Bowman's capsule per unit time http://purl.obolibrary.org/obo/MP_0005528 decreased renal glomerular filtration rate http://purl.obolibrary.org/obo/MP_0002847 abnormal renal glomerular filtration rate less than the normal volume of water filtered out of the plasma through glomerular capillary walls into the Bowman's capsule per unit time http://purl.obolibrary.org/obo/MP_0005529 abnormal renal vascular resistance http://purl.obolibrary.org/obo/MP_0005532 abnormal vascular resistance deviation from the normal force opposing blood flow in the kidney blood vessels http://purl.obolibrary.org/obo/MP_0005530 decreased renal vascular resistance http://purl.obolibrary.org/obo/MP_0005529 abnormal renal vascular resistance less than the normal force opposing blood flow in the kidney blood vessels http://purl.obolibrary.org/obo/MP_0005531 increased renal vascular resistance http://purl.obolibrary.org/obo/MP_0005529 abnormal renal vascular resistance greater than the normal force opposing blood flow in the kidney blood vessels http://purl.obolibrary.org/obo/MP_0005533 increased body temperature http://purl.obolibrary.org/obo/MP_0005535 abnormal body temperature greater than the level of heat natural to a living being http://purl.obolibrary.org/obo/MP_0005534 decreased body temperature http://purl.obolibrary.org/obo/MP_0005535 abnormal body temperature less than the level of heat natural to a living being http://purl.obolibrary.org/obo/MP_0005535 abnormal body temperature http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis deviation in the level of heat natural to a living being http://purl.obolibrary.org/obo/MP_0005536 Leydig cell hypoplasia http://purl.obolibrary.org/obo/MP_0002786 abnormal Leydig cell morphology reduced numbers of the interstitial cells of the seminiferous tubules that secrete testosterone http://purl.obolibrary.org/obo/MP_0005540 decreased urine albumin level http://purl.obolibrary.org/obo/MP_0002963 decreased urine protein level less than the normal amount of albumin in the urine http://purl.obolibrary.org/obo/MP_0005541 abnormal iris stromal pigmentation http://purl.obolibrary.org/obo/MP_0005208 abnormal iris stroma morphology any anomaly in the coloring of the framework of the iris http://purl.obolibrary.org/obo/MP_0005542 corneal vascularization http://purl.obolibrary.org/obo/MP_0003711 pathological neovascularization formation of blood vessels in the cornea, which normally lacks vessels http://purl.obolibrary.org/obo/MP_0005544 corneal deposits http://purl.obolibrary.org/obo/MP_0001312 abnormal cornea morphology accumulation of minerals, proteins, or other anomalous substances on the cornea http://purl.obolibrary.org/obo/MP_0005547 abnormal Muller cell morphology http://purl.obolibrary.org/obo/MP_0001325 abnormal retina morphology any structural anomaly of the elongated neuroglial cells that traverse all the layers of the retina and that act as supporting elements http://purl.obolibrary.org/obo/MP_0005548 retinal pigment epithelium atrophy http://purl.obolibrary.org/obo/MP_0005201 abnormal retinal pigment epithelium morphology acquired diminution of the size of the epithelial layer of the retina composed of cells containing pigment granules, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0005549 retinal pigment epithelium hyperplasia http://purl.obolibrary.org/obo/MP_0005201 abnormal retinal pigment epithelium morphology increased numbers of cells in the epithelial layer of the retina composed of cells containing pigment granules http://purl.obolibrary.org/obo/MP_0005553 increased circulating creatinine level http://purl.obolibrary.org/obo/MP_0009644 uremia greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction http://purl.obolibrary.org/obo/MP_0005554 decreased circulating creatinine level http://purl.obolibrary.org/obo/MP_0005328 abnormal circulating creatinine level less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction http://purl.obolibrary.org/obo/MP_0005556 abnormal renal filtration rate http://purl.obolibrary.org/obo/MP_0013285 abnormal renal filtration altered ability of the kidneys to remove substances from the plasma for excretion in a specific period of time http://purl.obolibrary.org/obo/MP_0005557 increased creatinine clearance http://purl.obolibrary.org/obo/MP_0005556 abnormal renal filtration rate increased rate of the process in which creatine is removed from the blood via renal filtration and its constituent parts degraded http://purl.obolibrary.org/obo/MP_0005558 decreased creatinine clearance http://purl.obolibrary.org/obo/MP_0005556 abnormal renal filtration rate decreased rate of the process in which creatine is removed from the blood via renal filtration and its constituent parts degraded http://purl.obolibrary.org/obo/MP_0005561 increased mean corpuscular hemoglobin http://purl.obolibrary.org/obo/MP_0001589 abnormal mean corpuscular hemoglobin greater than the average levels of hemoglobin contained in an erythrocyte http://purl.obolibrary.org/obo/MP_0005562 decreased mean corpuscular hemoglobin http://purl.obolibrary.org/obo/MP_0001589 abnormal mean corpuscular hemoglobin less than the average levels of hemoglobin contained in an erythrocyte http://purl.obolibrary.org/obo/MP_0005564 increased hemoglobin content http://purl.obolibrary.org/obo/MP_0005563 abnormal hemoglobin content increase in the total hemoglobin content in the circulating blood http://purl.obolibrary.org/obo/MP_0005565 increased blood urea nitrogen level http://purl.obolibrary.org/obo/MP_0009644 uremia high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function http://purl.obolibrary.org/obo/MP_0005566 decreased blood urea nitrogen level http://purl.obolibrary.org/obo/MP_0005265 abnormal blood urea nitrogen level low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function http://purl.obolibrary.org/obo/MP_0005567 decreased circulating total protein level http://purl.obolibrary.org/obo/MP_0011888 abnormal circulating total protein level total serum protein level below the normal range http://purl.obolibrary.org/obo/MP_0005568 increased circulating total protein level http://purl.obolibrary.org/obo/MP_0011888 abnormal circulating total protein level total serum protein level above the normal range http://purl.obolibrary.org/obo/MP_0005571 decreased lactate dehydrogenase level http://purl.obolibrary.org/obo/MP_0002943 abnormal lactate dehydrogenase level reduced level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate http://purl.obolibrary.org/obo/MP_0005572 abnormal pulmonary respiratory rate http://purl.obolibrary.org/obo/MP_0001951 abnormal breathing pattern deviation from the normal number of breaths per minute http://purl.obolibrary.org/obo/MP_0005573 increased pulmonary respiratory rate http://purl.obolibrary.org/obo/MP_0005572 abnormal pulmonary respiratory rate greater than the normal number of breaths per minute http://purl.obolibrary.org/obo/MP_0005574 decreased pulmonary respiratory rate http://purl.obolibrary.org/obo/MP_0005572 abnormal pulmonary respiratory rate fewer than the normal number of breaths per minute http://purl.obolibrary.org/obo/MP_0005577 uterus prolapse http://purl.obolibrary.org/obo/MP_0001120 abnormal uterus morphology downward movement, and possible external appearance, of the uterus through the vagina http://purl.obolibrary.org/obo/MP_0005578 teratozoospermia http://purl.obolibrary.org/obo/MP_0006362 abnormal male germ cell morphology presence of structurally anomalous spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends http://purl.obolibrary.org/obo/MP_0005580 periinsulitis http://purl.obolibrary.org/obo/MP_0001869 pancreas inflammation an accumulation of macrophages, dendritic cells, and B and T lymphocytes in the periductal areas of the pancreas but outside the islet cell areas; often occurs prior to intra-insulitis of the islet cell areas http://purl.obolibrary.org/obo/MP_0005581 abnormal renin activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity altered ability of this enzyme to cleave angiotensionogen and create angiotensin I http://purl.obolibrary.org/obo/MP_0005582 increased renin activity http://purl.obolibrary.org/obo/MP_0005581 abnormal renin activity greater than the normal ability of this enzyme to cleave angiotensionogen and create angiotensin I http://purl.obolibrary.org/obo/MP_0005583 decreased renin activity http://purl.obolibrary.org/obo/MP_0005581 abnormal renin activity less than the normal ability of this enzyme to cleave angiotensionogen and create angiotensin I http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity http://purl.obolibrary.org/obo/MP_0005266 abnormal metabolism altered ability of any enzyme or their cofactors, to act as catalysts to induce chemical changes in other substances http://purl.obolibrary.org/obo/MP_0005585 increased tidal volume http://purl.obolibrary.org/obo/MP_0002313 abnormal tidal volume greater than the normal volume of air inspired or expired during each normal respiratory cycle http://purl.obolibrary.org/obo/MP_0005586 decreased tidal volume http://purl.obolibrary.org/obo/MP_0002313 abnormal tidal volume less than the normal volume of air inspired or expired during each normal respiratory cycle http://purl.obolibrary.org/obo/MP_0005587 abnormal Meckel's cartilage morphology http://purl.obolibrary.org/obo/MP_0003935 abnormal craniofacial development any structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments http://purl.obolibrary.org/obo/MP_0005590 increased vasodilation http://purl.obolibrary.org/obo/MP_0001613 abnormal vasodilation greater than the expected or normal widening of the lumen of the blood vessels http://purl.obolibrary.org/obo/MP_0005591 decreased vasodilation http://purl.obolibrary.org/obo/MP_0001613 abnormal vasodilation less than the expected or normal widening of the lumen of the blood vessels http://purl.obolibrary.org/obo/MP_0005596 increased susceptibility to type I hypersensitivity reaction http://purl.obolibrary.org/obo/MP_0005088 increased acute inflammation greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks http://purl.obolibrary.org/obo/MP_0005597 decreased susceptibility to type I hypersensitivity reaction http://purl.obolibrary.org/obo/MP_0005087 decreased acute inflammation less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks http://purl.obolibrary.org/obo/MP_0005598 decreased ventricle muscle contractility http://purl.obolibrary.org/obo/MP_0005140 decreased cardiac muscle contractility reduced ability of the heart ventricle muscle to shorten or to develop increased tension, often measured by ventricular ejection fraction volume http://purl.obolibrary.org/obo/MP_0005599 increased cardiac muscle contractility http://purl.obolibrary.org/obo/MP_0002972 abnormal cardiac muscle contractility greater than the normal ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max, fractional shortening (FS), velocity of circumferential fiber shortening (Vcfc), peak of aortic outflow velocity (PAV), and ventricular ejection fraction volume http://purl.obolibrary.org/obo/MP_0005600 increased ventricle muscle contractility http://purl.obolibrary.org/obo/MP_0005599 increased cardiac muscle contractility greater than the normal ability of the heart ventricle muscle to shorten or to develop increased tension, often measured by ventricular ejection fraction volume http://purl.obolibrary.org/obo/MP_0005601 increased angiogenesis http://purl.obolibrary.org/obo/MP_0000260 abnormal angiogenesis enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network http://purl.obolibrary.org/obo/MP_0005602 decreased angiogenesis http://purl.obolibrary.org/obo/MP_0000260 abnormal angiogenesis reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network http://purl.obolibrary.org/obo/MP_0005603 neuron hypertrophy http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology increased mass of any of the structural and functional units of the nervous system, which consist of the nerve cell body, the dendrites, and the axon http://purl.obolibrary.org/obo/MP_0005604 hyperekplexia http://purl.obolibrary.org/obo/MP_0001486 abnormal startle reflex disorder characterized by pathologic startle responses, protective reactions to unanticipated, potentially threatening, stimuli of any type, particularly auditory http://purl.obolibrary.org/obo/MP_0005606 increased bleeding time http://purl.obolibrary.org/obo/MP_0002551 abnormal blood coagulation greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function http://purl.obolibrary.org/obo/MP_0005607 decreased bleeding time http://purl.obolibrary.org/obo/MP_0002551 abnormal blood coagulation less than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function http://purl.obolibrary.org/obo/MP_0005608 cardiac interstitial fibrosis http://purl.obolibrary.org/obo/MP_0003141 cardiac fibrosis formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process http://purl.obolibrary.org/obo/MP_0005609 abnormal circulating antidiuretic hormone level http://purl.obolibrary.org/obo/MP_0005418 abnormal circulating hormone level deviation from the normal concentration of the peptide hormone in the blood that is normally released by the neurohypophysis to control water metabolism and balance by regulating water loss; it also contracts smooth muscle http://purl.obolibrary.org/obo/MP_0005610 increased circulating antidiuretic hormone level http://purl.obolibrary.org/obo/MP_0005609 abnormal circulating antidiuretic hormone level greater than the normal concentration of the peptide hormone in the blood that is normally released by the neurohypophysis to control water metabolism and balance by regulating water loss; it also contracts smooth muscle http://purl.obolibrary.org/obo/MP_0005611 decreased circulating antidiuretic hormone level http://purl.obolibrary.org/obo/MP_0005609 abnormal circulating antidiuretic hormone level less than the normal concentration of the peptide hormone in the blood that is normally released by the neurohypophysis to control water metabolism and balance by regulating water loss; it also contracts smooth muscle http://purl.obolibrary.org/obo/MP_0005612 decreased susceptibility to type II hypersensitivity reaction http://purl.obolibrary.org/obo/MP_0005087 decreased acute inflammation less likelihood of or resistance to developing a response caused by an Ag-Ab reaction; antibodies are directly or indirectly cytotoxic to antigens on cell surfaces or in connective tissues; most often involves IgG and IgM; complement activation is usually involved http://purl.obolibrary.org/obo/MP_0005613 increased susceptibility to type II hypersensitivity reaction http://purl.obolibrary.org/obo/MP_0005088 increased acute inflammation greater likelihood or resistance to developing a response caused by an Ag-Ab reaction; antibodies are directly or indirectly cytotoxic to antigens on cell surfaces or in connective tissues; most often involves IgG and IgM; complement activation is usually involved http://purl.obolibrary.org/obo/MP_0005614 decreased susceptibility to type III hypersensitivity reaction http://purl.obolibrary.org/obo/MP_0005087 decreased acute inflammation less likelihood of or resistance to developing tissue injury mediated by immune complexes; generally involves immune complexes formed in the blood via Abs encountering circulating Ag; Ag-Ab complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury http://purl.obolibrary.org/obo/MP_0005615 increased susceptibility to type III hypersensitivity reaction http://purl.obolibrary.org/obo/MP_0005088 increased acute inflammation greater likelihood of developing tissue injury mediated by immune complexes; generally involves immune complexes formed in the blood via antibodies encountering circulating antigen; Ag-Ab complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury http://purl.obolibrary.org/obo/MP_0005616 decreased susceptibility to type IV hypersensitivity reaction http://purl.obolibrary.org/obo/MP_0005087 decreased acute inflammation less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact http://purl.obolibrary.org/obo/MP_0005617 increased susceptibility to type IV hypersensitivity reaction http://purl.obolibrary.org/obo/MP_0005088 increased acute inflammation greater likelihood of developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact http://purl.obolibrary.org/obo/MP_0005618 decreased urine potassium level http://purl.obolibrary.org/obo/MP_0004820 abnormal urine potassium level less than the normal amount of potassium in the urine http://purl.obolibrary.org/obo/MP_0005619 increased urine potassium level http://purl.obolibrary.org/obo/MP_0004820 abnormal urine potassium level greater than normal amount of potassium in the urine http://purl.obolibrary.org/obo/MP_0005623 abnormal meninges morphology http://purl.obolibrary.org/obo/MP_0003632 abnormal nervous system morphology any structural anomaly in any of the membranes covering the spinal cord and brain, including the dura mater (external), arachnoid (middle), and pia mater (internal) http://purl.obolibrary.org/obo/MP_0005624 abnormal plasma anion gap http://purl.obolibrary.org/obo/MP_0001765 abnormal ion homeostasis measurement of the interval between the sum of routinely measured cations minus the sum of the routinely measured anions in the blood; the anion gap = (Na+ + K+) - (Cl- + HCO3-) where Na- is sodium, K+ is potassium, Cl- is chloride, and HCO3- is bicarbonate http://purl.obolibrary.org/obo/MP_0005625 increased plasma anion gap http://purl.obolibrary.org/obo/MP_0005624 abnormal plasma anion gap greater than the normal interval between the sum of routinely measured cations minus the sum of the routinely measured anions in the blood; the anion gap = (Na+ + K+) - (Cl- + HCO3-) where Na- is sodium, K+ is potassium, Cl- is chloride, and HCO3- is bicarbonate; high anion gap is indicative of metabolic acidosis http://purl.obolibrary.org/obo/MP_0005626 decreased plasma anion gap http://purl.obolibrary.org/obo/MP_0005624 abnormal plasma anion gap less than the normal interval between the sum of routinely measured cations minus the sum of the routinely measured anions in the blood; the anion gap = (Na+ + K+) - (Cl- + HCO3-) where Na- is sodium, K+ is potassium, Cl- is chloride, and HCO3- is bicarbonate; low anion gap is relatively rare but may occur from the presence of abnormal positively charged proteins, as in multiple myeloma http://purl.obolibrary.org/obo/MP_0005627 increased circulating potassium level http://purl.obolibrary.org/obo/MP_0002668 abnormal circulating potassium level greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle http://purl.obolibrary.org/obo/MP_0005629 abnormal lung weight http://purl.obolibrary.org/obo/MP_0004881 abnormal lung size anomaly in the average weight of the lung http://purl.obolibrary.org/obo/MP_0005630 increased lung weight http://purl.obolibrary.org/obo/MP_0005629 abnormal lung weight greater than average weight of the lung http://purl.obolibrary.org/obo/MP_0005631 decreased lung weight http://purl.obolibrary.org/obo/MP_0005629 abnormal lung weight reduced average weight of the lung http://purl.obolibrary.org/obo/MP_0005632 decreased circulating aspartate transaminase level http://purl.obolibrary.org/obo/MP_0000203 abnormal circulating aspartate transaminase level less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction http://purl.obolibrary.org/obo/MP_0005633 increased circulating sodium level http://purl.obolibrary.org/obo/MP_0001776 abnormal circulating sodium level greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume http://purl.obolibrary.org/obo/MP_0005634 decreased circulating sodium level http://purl.obolibrary.org/obo/MP_0001776 abnormal circulating sodium level less than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume http://purl.obolibrary.org/obo/MP_0005635 decreased circulating bilirubin level http://purl.obolibrary.org/obo/MP_0001569 abnormal circulating bilirubin level reduced concentration in the blood of the bile pigment bilirubin, normally found in the liver and in red blood cells http://purl.obolibrary.org/obo/MP_0005638 hemochromatosis http://purl.obolibrary.org/obo/MP_0001770 abnormal iron level disorder due to the deposition of hemosiderin in the parenchymal cells, causing tissue damage and dysfunction of the liver, pancreas, heart, and pituitary http://purl.obolibrary.org/obo/MP_0005639 hemosiderosis http://purl.obolibrary.org/obo/MP_0001770 abnormal iron level condition in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the reticuloendothelial system, without demonstrable tissue damage http://purl.obolibrary.org/obo/MP_0005640 abnormal mean corpuscular hemoglobin concentration http://purl.obolibrary.org/obo/MP_0001588 abnormal hemoglobin deviation from the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices http://purl.obolibrary.org/obo/MP_0005641 increased mean corpuscular hemoglobin concentration http://purl.obolibrary.org/obo/MP_0005640 abnormal mean corpuscular hemoglobin concentration greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices http://purl.obolibrary.org/obo/MP_0005642 decreased mean corpuscular hemoglobin concentration http://purl.obolibrary.org/obo/MP_0005640 abnormal mean corpuscular hemoglobin concentration less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices http://purl.obolibrary.org/obo/MP_0005643 decreased dopamine level http://purl.obolibrary.org/obo/MP_0001905 abnormal dopamine level less than the normal amount of this catecholamine neurotransmitter and neurohormone, derived from tyrosine and the precursor to norepinephrine and epinephrine; functions as a neurotransmitter in the brain and as a hormone to inhibit the release of prolactin from the anterior lobe of the pituitary http://purl.obolibrary.org/obo/MP_0005648 heart right ventricle degeneration http://purl.obolibrary.org/obo/MP_0003920 abnormal heart right ventricle morphology replacement of cardiomyocytes in the right ventricle with fibrous tissue and/or fat http://purl.obolibrary.org/obo/MP_0005649 increased spleen neoplasm incidence http://purl.obolibrary.org/obo/MP_0010296 increased hemolymphoid system tumor incidence greater than the expected number of a neoplasm of the spleen, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0005651 abnormal gonad rudiment morphology http://purl.obolibrary.org/obo/MP_0003936 abnormal reproductive system development any structural anomaly of the undifferentiated mesoderm that gives rise to the gonads http://purl.obolibrary.org/obo/MP_0005653 phototoxicity http://purl.obolibrary.org/obo/MP_0005501 abnormal skin physiology condition caused by overexposure to UV light or from the combination of exposure to specific wavelengths and a phototoxic substance http://purl.obolibrary.org/obo/MP_0005654 porphyria http://purl.obolibrary.org/obo/MP_0004147 increased porphyrin level acquired or inherited group of disorders characterized by excessive production of porphyrins or their precursors; if acquired, it results from inhibition of enzymes in the heme metabolic pathway by drugs, toxins or abnormal metabolites http://purl.obolibrary.org/obo/MP_0005657 abnormal neural plate morphology http://purl.obolibrary.org/obo/MP_0003861 abnormal nervous system development any structural anomaly of the flat, thickened layer of ectodermal cells in the neuroectodermal area of the embryo's dorsal surface that develops into the neural tube and neural crest http://purl.obolibrary.org/obo/MP_0005658 increased susceptibility to diet-induced obesity http://purl.obolibrary.org/obo/MP_0004890 decreased energy expenditure more likely to become excessively overweight or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat http://purl.obolibrary.org/obo/MP_0005659 decreased susceptibility to diet-induced obesity http://purl.obolibrary.org/obo/MP_0004889 increased energy expenditure less likely to become excessively overweight or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat http://purl.obolibrary.org/obo/MP_0005661 decreased circulating adrenaline level http://purl.obolibrary.org/obo/MP_0005660 abnormal circulating adrenaline level less than the normal concentration in the blood of a catecholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels http://purl.obolibrary.org/obo/MP_0005662 increased circulating adrenaline level http://purl.obolibrary.org/obo/MP_0005660 abnormal circulating adrenaline level greater than the normal concentration in the blood of a catecholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels http://purl.obolibrary.org/obo/MP_0005664 decreased circulating noradrenaline level http://purl.obolibrary.org/obo/MP_0012574 decreased noradrenaline level less than the normal blood amount of the hormone secreted by the adrenal medulla and acts as a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS; noradrenaline is the demethylated biosynthetic precursor of epinephrine http://purl.obolibrary.org/obo/MP_0005665 increased circulating noradrenaline level http://purl.obolibrary.org/obo/MP_0012575 increased noradrenaline level greater than the normal blood amount of the hormone secreted by the adrenal medulla and acts as a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS; noradrenaline is the demethylated biosynthetic precursor of epinephrine http://purl.obolibrary.org/obo/MP_0005667 abnormal circulating leptin level http://purl.obolibrary.org/obo/MP_0005418 abnormal circulating hormone level anomaly in the blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance http://purl.obolibrary.org/obo/MP_0005668 decreased circulating leptin level http://purl.obolibrary.org/obo/MP_0005667 abnormal circulating leptin level less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance http://purl.obolibrary.org/obo/MP_0005669 increased circulating leptin level http://purl.obolibrary.org/obo/MP_0005667 abnormal circulating leptin level greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance http://purl.obolibrary.org/obo/MP_0005670 abnormal white adipose tissue physiology http://purl.obolibrary.org/obo/MP_0005666 abnormal adipose tissue physiology any functional anomaly in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels http://purl.obolibrary.org/obo/MP_0005671 abnormal response to transplant http://purl.obolibrary.org/obo/MP_0001790 abnormal immune system physiology anomaly in the body's reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual http://purl.obolibrary.org/obo/MP_0005672 increased susceptibility to graft versus host disease http://purl.obolibrary.org/obo/MP_0005671 abnormal response to transplant greater likelihood of developing clinical symptoms of anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the a graft versus host reaction, which is an immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host http://purl.obolibrary.org/obo/MP_0005673 decreased susceptibility to graft versus host disease http://purl.obolibrary.org/obo/MP_0005671 abnormal response to transplant less likelihood of developing clinical symptoms of anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the a graft versus host reaction, which is an immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host http://purl.obolibrary.org/obo/MP_0005675 small gallbladder http://purl.obolibrary.org/obo/MP_0005084 abnormal gallbladder morphology reduced size of the gall bladder, the organ that serves as a storage reservoir for bile http://purl.obolibrary.org/obo/MP_0006000 abnormal corneal epithelium morphology http://purl.obolibrary.org/obo/MP_0001312 abnormal cornea morphology any structural anomaly of the smooth stratified squamous epithelium that covers the outer surface of the cornea http://purl.obolibrary.org/obo/MP_0006001 abnormal intestinal transit time http://purl.obolibrary.org/obo/MP_0011082 abnormal gastrointestinal motility increase or decrease in the time it takes for a bolus of material to pass through the intestine http://purl.obolibrary.org/obo/MP_0006002 abnormal small intestinal transit time http://purl.obolibrary.org/obo/MP_0006001 abnormal intestinal transit time increase or decrease in the time it takes for a bolus of material to pass through the small intestine http://purl.obolibrary.org/obo/MP_0006003 abnormal large intestinal transit time http://purl.obolibrary.org/obo/MP_0006001 abnormal intestinal transit time increase or decrease in the time it takes for a bolus of material to pass through the large intestine http://purl.obolibrary.org/obo/MP_0006009 abnormal neuronal migration http://purl.obolibrary.org/obo/MP_0004811 abnormal neuron physiology any anomaly in the movement of immature neurons from germinal zones to specific positions where they will reside as they mature http://purl.obolibrary.org/obo/MP_0006010 absent strial intermediate cells http://purl.obolibrary.org/obo/MP_0004367 abnormal strial intermediate cell morphology absence of the melanocytes (i.e. crest-derived intermediate cells) normally located within the intrastrial space; loss of strial intermediate cells is known to lead to loss of the endocochlear potential http://purl.obolibrary.org/obo/MP_0006012 dilated endolymphatic duct http://purl.obolibrary.org/obo/MP_0006011 abnormal endolymphatic duct morphology stretched or widened aperture of the luminal space of the endolymphatic duct http://purl.obolibrary.org/obo/MP_0006013 absent endolymphatic sac http://purl.obolibrary.org/obo/MP_0006011 abnormal endolymphatic duct morphology absence of the dilated blind extremity of the endolymphatic duct, which lies external to the dura on the posterior aspect of the petrous part of the temporal bone http://purl.obolibrary.org/obo/MP_0006014 dilated endolymphatic sac http://purl.obolibrary.org/obo/MP_0006011 abnormal endolymphatic duct morphology stretched or widened aperture of the luminal space of the endolymphatic sac http://purl.obolibrary.org/obo/MP_0006015 dilated lateral semicircular canal http://purl.obolibrary.org/obo/MP_0000037 abnormal lateral semicircular canal morphology stretched or widened aperture of the luminal space of the lateral semicircular canal http://purl.obolibrary.org/obo/MP_0006016 dilated posterior semicircular canal http://purl.obolibrary.org/obo/MP_0002858 abnormal posterior semicircular canal morphology stretched or widened aperture of the luminal space of the posterior semicircular canal http://purl.obolibrary.org/obo/MP_0006017 dilated superior semicircular canal http://purl.obolibrary.org/obo/MP_0003069 abnormal superior semicircular canal morphology stretched or widened aperture of the luminal space of the superior semicircular canal http://purl.obolibrary.org/obo/MP_0006018 abnormal tympanic membrane morphology http://purl.obolibrary.org/obo/MP_0000049 abnormal middle ear morphology any structural anomaly of the thin, tense membrane forming the greater part of the lateral wall of the tympanic cavity and separating it from the external acoustic meatus; the tympanic membrane constitutes the boundary between the external and middle ear http://purl.obolibrary.org/obo/MP_0006019 absent tympanic membrane http://purl.obolibrary.org/obo/MP_0006018 abnormal tympanic membrane morphology absence of the thin, tense membrane forming the greater part of the lateral wall of the tympanic cavity and separating it from the external acoustic meatus; the tympanic membrane constitutes the boundary between the external and middle ear http://purl.obolibrary.org/obo/MP_0006020 decreased tympanic ring size http://purl.obolibrary.org/obo/MP_0000030 abnormal tympanic ring morphology smaller than average tympanic ring http://purl.obolibrary.org/obo/MP_0006021 abnormal Reissner membrane morphology http://purl.obolibrary.org/obo/MP_0000031 abnormal cochlea morphology any structural anomaly of the membrane which separates the cochlear duct from the vestibular canal, i.e. the endolymph of the scala media from the perilymph of the scala vestibuli; the Reissner membrane consists of squamous epithelial cells with microvilli toward the ductus, a basement membrane, and a thin layer of connective tissue toward the scala http://purl.obolibrary.org/obo/MP_0006022 absent Reissner membrane http://purl.obolibrary.org/obo/MP_0006021 abnormal Reissner membrane morphology loss of the membrane which separates the cochlear duct from the vestibular canal http://purl.obolibrary.org/obo/MP_0006023 detached Reissner membrane http://purl.obolibrary.org/obo/MP_0006021 abnormal Reissner membrane morphology partial or complete loss of connection between the membrane and the stria vascularis, the periosteum covering the lamina spiralis ossea, or both http://purl.obolibrary.org/obo/MP_0006024 collapsed Reissner membrane http://purl.obolibrary.org/obo/MP_0006021 abnormal Reissner membrane morphology the Reissner's membrane, which normally separates the scala media from the scala vestibuli, has collapsed onto the spiral limbus and the tectorial membrane of the organ of Corti http://purl.obolibrary.org/obo/MP_0006025 distended Reissner membrane http://purl.obolibrary.org/obo/MP_0006021 abnormal Reissner membrane morphology an increase in the volume of endolymphatic fluid that results in distortion of the vestibular membrane http://purl.obolibrary.org/obo/MP_0006026 dilated terminal bronchiole tubes http://purl.obolibrary.org/obo/MP_0002268 abnormal terminal bronchiole morphology stretched or widened aperture of the luminal space of the terminal lung buds http://purl.obolibrary.org/obo/MP_0006027 impaired lung alveolus development http://purl.obolibrary.org/obo/MP_0010995 abnormal lung alveolus development a block or reduction in the formation of the sacs for holding air in the lungs, which are formed by the terminal dilation of air passageways http://purl.obolibrary.org/obo/MP_0006029 abnormal sclerotome morphology http://purl.obolibrary.org/obo/MP_0002113 abnormal skeleton development any structural anomaly of the group of mesenchymal cells that emerge from the ventromedial part of a somite and migrate toward the notochord; normally, sclerotomal cells from adjacent somites become merged in intersomitically located masses that are the primordia of the centra of the vertebrae http://purl.obolibrary.org/obo/MP_0006030 abnormal otic vesicle development http://purl.obolibrary.org/obo/MP_0009806 abnormal otic vesicle morphology anomaly in the formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear http://purl.obolibrary.org/obo/MP_0006032 abnormal ureteric bud morphology http://purl.obolibrary.org/obo/MP_0003942 abnormal urinary system development any structural anomaly of the epithelial swelling on the metanephric duct that elongates to invade the adjacent metanephric mesenchyme; interactions between the ureteric bud and the metanephric mesenchyme leads to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue http://purl.obolibrary.org/obo/MP_0006033 abnormal external auditory canal morphology http://purl.obolibrary.org/obo/MP_0002177 abnormal outer ear morphology any structural anomaly of the canal that connects the outer and middle ear http://purl.obolibrary.org/obo/MP_0006034 myoglobinuria http://purl.obolibrary.org/obo/MP_0002962 increased urine protein level presence of myoglobin in the urine http://purl.obolibrary.org/obo/MP_0006035 abnormal mitochondrion morphology http://purl.obolibrary.org/obo/MP_0000358 abnormal cell morphology any structural anomaly of the semiautonomous, self replicating organelles that occur in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells; mitochondria are notably the site of tissue respiration http://purl.obolibrary.org/obo/MP_0006036 abnormal mitochondrial physiology http://purl.obolibrary.org/obo/MP_0005621 abnormal cell physiology any functional anomaly of the cellular organelles responsible for energy production http://purl.obolibrary.org/obo/MP_0006037 abnormal mitochondrial proliferation http://purl.obolibrary.org/obo/MP_0006036 abnormal mitochondrial physiology anomaly in the expansion rate of the cellular organelles responsible for energy production by division http://purl.obolibrary.org/obo/MP_0006038 increased mitochondrial proliferation http://purl.obolibrary.org/obo/MP_0006037 abnormal mitochondrial proliferation increase in the expansion rate of the cellular organelles responsible for energy production by division http://purl.obolibrary.org/obo/MP_0006039 decreased mitochondrial proliferation http://purl.obolibrary.org/obo/MP_0006037 abnormal mitochondrial proliferation reduction in the expansion rate of the cellular organelles responsible for energy production by division http://purl.obolibrary.org/obo/MP_0006044 tricuspid valve regurgitation http://purl.obolibrary.org/obo/MP_0006046 atrioventricular valve regurgitation the backward reflux of blood through the tricuspid valve, due to insufficiency caused by disease, aging or congenital malformation http://purl.obolibrary.org/obo/MP_0006045 mitral valve regurgitation http://purl.obolibrary.org/obo/MP_0006046 atrioventricular valve regurgitation the backward reflux of blood through the mitral valve, due to insufficiency caused by disease, aging or congenital malformation http://purl.obolibrary.org/obo/MP_0006046 atrioventricular valve regurgitation http://purl.obolibrary.org/obo/MP_0009384 cardiac valve regurgitation the backward reflux of blood through the atrioventricular valve, due to insufficiency caused by disease, aging or congenital malformation http://purl.obolibrary.org/obo/MP_0006047 aortic valve regurgitation http://purl.obolibrary.org/obo/MP_0006049 semilunar valve regurgitation the backward reflux of blood through the aortic valve, due to insufficiency caused by disease, aging or congenital malformation http://purl.obolibrary.org/obo/MP_0006048 pulmonary valve regurgitation http://purl.obolibrary.org/obo/MP_0006049 semilunar valve regurgitation the backward reflux of blood through the pulmonary valve, due to insufficiency caused by disease, aging or congenital malformation http://purl.obolibrary.org/obo/MP_0006049 semilunar valve regurgitation http://purl.obolibrary.org/obo/MP_0009384 cardiac valve regurgitation the backward reflux of blood through the semilunar valve(s), due to insufficiency caused by disease, aging or congenital malformation http://purl.obolibrary.org/obo/MP_0006051 brainstem hemorrhage http://purl.obolibrary.org/obo/MP_0001915 intracranial hemorrhage bleeding into the brain stem http://purl.obolibrary.org/obo/MP_0006052 cerebellum hemorrhage http://purl.obolibrary.org/obo/MP_0001915 intracranial hemorrhage bleeding into the cerebellum http://purl.obolibrary.org/obo/MP_0006053 hypothalamus hemorrhage http://purl.obolibrary.org/obo/MP_0001915 intracranial hemorrhage bleeding into the hypothalamus http://purl.obolibrary.org/obo/MP_0006054 spinal hemorrhage http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology bleeding into the spine http://purl.obolibrary.org/obo/MP_0006056 increased vascular endothelial cell number http://purl.obolibrary.org/obo/MP_0006055 abnormal vascular endothelial cell morphology greater than normal number of cells lining the vasculature http://purl.obolibrary.org/obo/MP_0006057 decreased vascular endothelial cell number http://purl.obolibrary.org/obo/MP_0006055 abnormal vascular endothelial cell morphology less than normal number of cells lining the vasculature http://purl.obolibrary.org/obo/MP_0006058 decreased cerebral infarction size http://purl.obolibrary.org/obo/MP_0006059 decreased susceptibility to ischemic brain injury decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply http://purl.obolibrary.org/obo/MP_0006059 decreased susceptibility to ischemic brain injury http://purl.obolibrary.org/obo/MP_0005166 decreased susceptibility to injury less severe response, such as necrotic tissue size, to lack of adequate blood flow, due to trauma or disease, to support the normal functioning of all or part of the brain tissue, compared to controls http://purl.obolibrary.org/obo/MP_0006060 increased cerebral infarction size http://purl.obolibrary.org/obo/MP_0003076 increased susceptibility to ischemic brain injury increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply http://purl.obolibrary.org/obo/MP_0006061 right atrial isomerism http://purl.obolibrary.org/obo/MP_0006065 abnormal heart position or orientation anomaly in the asymmetry of the cardiac atria such that atria on both the left and right side have the morphology normally seen on the right side of the body http://purl.obolibrary.org/obo/MP_0006062 abnormal vena cava morphology http://purl.obolibrary.org/obo/MP_0002725 abnormal vein morphology any structural anomaly of either of the two largest veins in the body http://purl.obolibrary.org/obo/MP_0006063 abnormal inferior vena cava morphology http://purl.obolibrary.org/obo/MP_0006062 abnormal vena cava morphology any structural anomaly of the principal vein draining blood from the lower portion of the body http://purl.obolibrary.org/obo/MP_0006064 abnormal superior vena cava morphology http://purl.obolibrary.org/obo/MP_0006062 abnormal vena cava morphology any structural anomaly of the principal vein draining blood from the upper portion of the body and delivering it to the right ventricle of the heart http://purl.obolibrary.org/obo/MP_0006066 decreased clearance of atrial thrombosis http://purl.obolibrary.org/obo/MP_0001855 atrial thrombosis slower removal of a thrombus from the atria of the heart http://purl.obolibrary.org/obo/MP_0006067 increased clearance of atrial thrombosis http://purl.obolibrary.org/obo/MP_0001855 atrial thrombosis faster removal of a thrombus from the atria of the heart http://purl.obolibrary.org/obo/MP_0006068 abnormal horizontal cell morphology http://purl.obolibrary.org/obo/MP_0001325 abnormal retina morphology any structural anomaly of the laterally interconnecting neurons in the outer plexiform layer of the retina that connect rods of one part of the retina with cones in another part of the retina http://purl.obolibrary.org/obo/MP_0006070 increased retinal photoreceptor cell number http://purl.obolibrary.org/obo/MP_0006006 increased sensory neuron number greater than the expected number of rods and/or cones http://purl.obolibrary.org/obo/MP_0006071 abnormal retinal progenitor cell morphology http://purl.obolibrary.org/obo/MP_0009772 abnormal retinal development any structural anomaly of the cells that give rise to the various cells of the retina http://purl.obolibrary.org/obo/MP_0006072 abnormal retinal apoptosis http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology increase or decrease in the number of cells in the retina undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0006073 abnormal retinal bipolar cell morphology http://purl.obolibrary.org/obo/MP_0001325 abnormal retina morphology any structural anomaly of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells http://purl.obolibrary.org/obo/MP_0006074 abnormal retinal rod bipolar cell morphology http://purl.obolibrary.org/obo/MP_0006073 abnormal retinal bipolar cell morphology any structural anomaly of the bipolar cells that function in low light and transmit signals only through amacrine cells http://purl.obolibrary.org/obo/MP_0006075 abnormal retinal cone bipolar cell morphology http://purl.obolibrary.org/obo/MP_0006073 abnormal retinal bipolar cell morphology any structural anomaly of the retinal bipolar cells that connect to both ganglion and amacrine cells http://purl.obolibrary.org/obo/MP_0006076 abnormal circulating homocysteine level http://purl.obolibrary.org/obo/MP_0005311 abnormal circulating amino acid level aberrant amount in the blood of sulfur-containing alpha-amino acid found in the plasma; blood levels are regulated by folic acid, vitamin B6 and vitamin B12 http://purl.obolibrary.org/obo/MP_0006077 inguinal hernia http://purl.obolibrary.org/obo/MP_0000757 herniated abdominal wall hernia through the abdominal wall in the region of the groin known as Hesselbach's triangle http://purl.obolibrary.org/obo/MP_0006078 abnormal nipple morphology http://purl.obolibrary.org/obo/MP_0000627 abnormal mammary gland morphology any structural anomaly of the erectile projection at the apex of the mammary gland where the lactiferous ducts open http://purl.obolibrary.org/obo/MP_0006080 CNS ischemia http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology inadequate blood flow to a region of the brain that may lead to cerebral infarction http://purl.obolibrary.org/obo/MP_0006083 abnormal blood vessel elastic tissue morphology http://purl.obolibrary.org/obo/MP_0001614 abnormal blood vessel morphology any structural anomaly of the tissue that is found in the tunica media of the vessels wall and allows vessels to stretch http://purl.obolibrary.org/obo/MP_0006085 myocardial necrosis http://purl.obolibrary.org/obo/MP_0005329 abnormal myocardium layer morphology morphological changes resulting from pathological death of myocardial tissue; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0006086 decreased body mass index http://purl.obolibrary.org/obo/MP_0020182 abnormal body mass index less than normal average of a measure of weight for height http://purl.obolibrary.org/obo/MP_0006087 increased body mass index http://purl.obolibrary.org/obo/MP_0020182 abnormal body mass index greater than normal average of a measure of weight for height http://purl.obolibrary.org/obo/MP_0006088 abnormal blood-cerebrospinal fluid barrier function http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology anomaly in the function of the group of barriers and transport systems in the choroid plexus located in the lateral, third, and fourth brain ventricles that controls the entrance of substances into the cerebrospinal fluid from the blood http://purl.obolibrary.org/obo/MP_0006093 arteriovenous malformation http://purl.obolibrary.org/obo/MP_0001614 abnormal blood vessel morphology fusion of an artery and vein without an intervening capillary bed http://purl.obolibrary.org/obo/MP_0006094 increased fat cell size http://purl.obolibrary.org/obo/MP_0009115 abnormal fat cell morphology increased size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals http://purl.obolibrary.org/obo/MP_0006095 absent amacrine cells http://purl.obolibrary.org/obo/MP_0008106 decreased amacrine cell number absence of the amacrine cells, which constitute one of the three types of interneurons found in the inner nuclear layer of the mature retina; they integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer http://purl.obolibrary.org/obo/MP_0006096 absent retinal bipolar cells http://purl.obolibrary.org/obo/MP_0006073 abnormal retinal bipolar cell morphology absence of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells http://purl.obolibrary.org/obo/MP_0006097 abnormal cerebellar lobule formation http://purl.obolibrary.org/obo/MP_0000857 abnormal cerebellar foliation anomaly in the formation of the lobes of the cerebellum http://purl.obolibrary.org/obo/MP_0006098 absent cerebellar lobules http://purl.obolibrary.org/obo/MP_0009964 abnormal cerebellum lobule morphology missing lobes of the cerebellum http://purl.obolibrary.org/obo/MP_0006099 thin cerebellar granule layer http://purl.obolibrary.org/obo/MP_0000886 abnormal cerebellar granule layer morphology reduced thickness of the innermost cortical layer of the cerebellum that contains granule cells http://purl.obolibrary.org/obo/MP_0006100 abnormal tegmentum morphology http://purl.obolibrary.org/obo/MP_0000897 abnormal midbrain morphology any structural anomaly of the floor of the midbrain which extends from the substantia nigra to the level of the cerebral aqueduct http://purl.obolibrary.org/obo/MP_0006101 absent tegmentum http://purl.obolibrary.org/obo/MP_0006100 abnormal tegmentum morphology absence or loss of the floor of the midbrain which extends from the substantia nigra to the level of the cerebral aqueduct http://purl.obolibrary.org/obo/MP_0006102 decreased tegmentum size http://purl.obolibrary.org/obo/MP_0006100 abnormal tegmentum morphology reduced size of the floor of the midbrain which extends from the substantia nigra to the level of the cerebral aqueduct http://purl.obolibrary.org/obo/MP_0006103 abnormal midbrain roof plate morphology http://purl.obolibrary.org/obo/MP_0000897 abnormal midbrain morphology any structural anomaly of the mesencephalic roof plate, including the caudal and rostral part of the midbrain roof http://purl.obolibrary.org/obo/MP_0006105 small tectum http://purl.obolibrary.org/obo/MP_0006104 abnormal tectum morphology reduced size of the rostral part of the midbrain roof http://purl.obolibrary.org/obo/MP_0006106 absent tectum http://purl.obolibrary.org/obo/MP_0006104 abnormal tectum morphology absence or loss of the rostral part of the midbrain roof http://purl.obolibrary.org/obo/MP_0006109 fibrillation http://purl.obolibrary.org/obo/MP_0001636 irregular heartbeat asynchronous contraction or quivering of individual cardiac muscle fibers http://purl.obolibrary.org/obo/MP_0006110 ventricular fibrillation http://purl.obolibrary.org/obo/MP_0006109 fibrillation asynchronous contraction or quivering of individual cardiac muscle fibers in the ventricles http://purl.obolibrary.org/obo/MP_0006112 angina http://purl.obolibrary.org/obo/MP_0006111 abnormal coronary circulation inadequate blood flow to and/or oxygenation of the heart producing chest pain http://purl.obolibrary.org/obo/MP_0006114 cardiac murmur http://purl.obolibrary.org/obo/MP_0002128 abnormal blood circulation abnormal turbulent blood flow through the valves or outflow tract results in abnormal heart sounds http://purl.obolibrary.org/obo/MP_0006115 aortic valve atresia http://purl.obolibrary.org/obo/MP_0002747 abnormal aortic valve morphology congenital closure of the aortic valve http://purl.obolibrary.org/obo/MP_0006116 calcified aortic valve http://purl.obolibrary.org/obo/MP_0002747 abnormal aortic valve morphology pathologic deposition of calcium salts in the aortic valve http://purl.obolibrary.org/obo/MP_0006117 aortic valve stenosis http://purl.obolibrary.org/obo/MP_0010448 heart left ventricle outflow tract stenosis abnormal narrowing of the aortic valve http://purl.obolibrary.org/obo/MP_0006118 aortic valve prolapse http://purl.obolibrary.org/obo/MP_0002747 abnormal aortic valve morphology collapse of one or more of the aortic valve cusps backward allowing blood to leak backwards, usually the result of enlargement of one or more of the valve cusps http://purl.obolibrary.org/obo/MP_0006119 mitral valve atresia http://purl.obolibrary.org/obo/MP_0000286 abnormal mitral valve morphology congenital closure of the mitral valve http://purl.obolibrary.org/obo/MP_0006120 mitral valve prolapse http://purl.obolibrary.org/obo/MP_0000286 abnormal mitral valve morphology collapse of one or more of the mitral valve cusps backward allowing blood to leak backwards, usually the result of enlargement of one or more of the valve cusps http://purl.obolibrary.org/obo/MP_0006121 calcified mitral valve http://purl.obolibrary.org/obo/MP_0000286 abnormal mitral valve morphology pathologic deposition of calcium salts in the mitral valve http://purl.obolibrary.org/obo/MP_0006122 mitral valve stenosis http://purl.obolibrary.org/obo/MP_0000286 abnormal mitral valve morphology abnormal narrowing of the mitral valve http://purl.obolibrary.org/obo/MP_0006123 tricuspid valve atresia http://purl.obolibrary.org/obo/MP_0002624 abnormal tricuspid valve morphology congenital closure of the tricuspid valve http://purl.obolibrary.org/obo/MP_0006124 tricuspid valve stenosis http://purl.obolibrary.org/obo/MP_0002624 abnormal tricuspid valve morphology abnormal narrowing of the tricuspid valve http://purl.obolibrary.org/obo/MP_0006125 tricuspid valve prolapse http://purl.obolibrary.org/obo/MP_0002624 abnormal tricuspid valve morphology collapse of one or more of the tricuspid valve cusps backward allowing blood to leak backwards, usually the result of enlargement of one or more of the valve cusps http://purl.obolibrary.org/obo/MP_0006126 abnormal outflow tract development http://purl.obolibrary.org/obo/MP_0002925 abnormal cardiovascular development anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery and the ventricular outflow regions http://purl.obolibrary.org/obo/MP_0006128 pulmonary valve stenosis http://purl.obolibrary.org/obo/MP_0010449 heart right ventricle outflow tract stenosis abnormal narrowing of the pulmonary valve http://purl.obolibrary.org/obo/MP_0006129 pulmonary valve prolapse http://purl.obolibrary.org/obo/MP_0002748 abnormal pulmonary valve morphology collapse of one or more of the pulmonary valve cusps backward allowing blood to leak backwards, usually the result of enlargement of one or more of the valve cusps http://purl.obolibrary.org/obo/MP_0006130 pulmonary valve atresia http://purl.obolibrary.org/obo/MP_0002748 abnormal pulmonary valve morphology congenital closure of the pulmonary valve http://purl.obolibrary.org/obo/MP_0006131 calcified pulmonary valve http://purl.obolibrary.org/obo/MP_0002748 abnormal pulmonary valve morphology pathologic deposition of calcium salts in the pulmonary valve http://purl.obolibrary.org/obo/MP_0006132 calcified tricuspid valve http://purl.obolibrary.org/obo/MP_0002624 abnormal tricuspid valve morphology pathologic deposition of calcium salts in the tricuspid valve http://purl.obolibrary.org/obo/MP_0006133 calcified artery http://purl.obolibrary.org/obo/MP_0002191 abnormal artery morphology pathologic deposition of calcium salts in the arteries http://purl.obolibrary.org/obo/MP_0006134 artery occlusion http://purl.obolibrary.org/obo/MP_0002191 abnormal artery morphology blockage of blood flow through one or more arteries http://purl.obolibrary.org/obo/MP_0006136 varicose veins http://purl.obolibrary.org/obo/MP_0002725 abnormal vein morphology enlarged, twisted, painful superficial veins resulting from poorly functioning valves http://purl.obolibrary.org/obo/MP_0006137 venoocclusion http://purl.obolibrary.org/obo/MP_0002725 abnormal vein morphology blockage of blood flow through one or more veins http://purl.obolibrary.org/obo/MP_0006138 congestive heart failure http://purl.obolibrary.org/obo/MP_0001544 abnormal cardiovascular system physiology cardiac output is insufficient to supply blood throughout the body, resulting in the accumulation of fluid in the lungs and other body tissues; it is related mainly to salt and water retention in the tissues rather than directly to reduced blood flow; blood pools in the veins (vascular congestion) because the heart does not pump efficiently enough to allow it to return http://purl.obolibrary.org/obo/MP_0006140 increased cardiac rhabdomyoma incidence http://purl.obolibrary.org/obo/MP_0010391 increased rhabdomyoma incidence greater than the expected number of a benign tumor of the myocardium, occurring in a specific population in a given time period; it is most commonly seen in the young and is often associated with tuberous sclerosis http://purl.obolibrary.org/obo/MP_0006143 increased systemic arterial diastolic blood pressure http://purl.obolibrary.org/obo/MP_0002842 increased systemic arterial blood pressure abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed http://purl.obolibrary.org/obo/MP_0006144 increased systemic arterial systolic blood pressure http://purl.obolibrary.org/obo/MP_0002842 increased systemic arterial blood pressure abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries http://purl.obolibrary.org/obo/MP_0006145 legal blindness http://purl.obolibrary.org/obo/MP_0002001 blindness the best corrected visual acuity is 20/200, or the visual field is 20 degrees or less (sensu H. sapiens) http://purl.obolibrary.org/obo/MP_0006147 monocular blindness http://purl.obolibrary.org/obo/MP_0002001 blindness loss of vision in only one eye, may be transient http://purl.obolibrary.org/obo/MP_0006148 binocular blindness http://purl.obolibrary.org/obo/MP_0002001 blindness loss of vision in both eyes, may be transient http://purl.obolibrary.org/obo/MP_0006149 decreased visual acuity http://purl.obolibrary.org/obo/MP_0011832 abnormal visual acuity loss of visual acuity or ability to distinguish small details http://purl.obolibrary.org/obo/MP_0006150 double vision http://purl.obolibrary.org/obo/MP_0002090 abnormal vision two images are perceived when only a single object is present http://purl.obolibrary.org/obo/MP_0006151 astigmatism http://purl.obolibrary.org/obo/MP_0001312 abnormal cornea morphology the cornea is asymmetrically curved, causing out-of-focus vision http://purl.obolibrary.org/obo/MP_0006152 tunnel vision http://purl.obolibrary.org/obo/MP_0002090 abnormal vision loss of peripheral vision http://purl.obolibrary.org/obo/MP_0006153 hypermetropia http://purl.obolibrary.org/obo/MP_0002090 abnormal vision light entering the eye focuses behind the retina, instead of directly on it http://purl.obolibrary.org/obo/MP_0006154 eye abduction http://purl.obolibrary.org/obo/MP_0001389 abnormal eye movement abnormal movement of the eye laterally, or towards the temple http://purl.obolibrary.org/obo/MP_0006155 eye adduction http://purl.obolibrary.org/obo/MP_0001389 abnormal eye movement abnormal movement of the eye medially, or towards the nose http://purl.obolibrary.org/obo/MP_0006156 abnormal visual pursuit http://purl.obolibrary.org/obo/MP_0001389 abnormal eye movement anomaly in the ability to selectively track a moving object http://purl.obolibrary.org/obo/MP_0006157 palsy of the eye http://purl.obolibrary.org/obo/MP_0001389 abnormal eye movement the eye fails to move properly in all directions of gaze http://purl.obolibrary.org/obo/MP_0006158 vertical supranuclear palsy http://purl.obolibrary.org/obo/MP_0006157 palsy of the eye inability to move the eye vertically http://purl.obolibrary.org/obo/MP_0006159 ocular albinism http://purl.obolibrary.org/obo/MP_0008480 absent eye pigmentation absence of melanin (pigment) production in the eye with identifiable melanocytes present http://purl.obolibrary.org/obo/MP_0006160 heterochromatic iridis http://purl.obolibrary.org/obo/MP_0005102 abnormal iris pigmentation a difference in color between the irises of the two eyes or between parts of one iris http://purl.obolibrary.org/obo/MP_0006162 thick eyelids http://purl.obolibrary.org/obo/MP_0001340 abnormal eyelid morphology increased width of the eyelid http://purl.obolibrary.org/obo/MP_0006163 ankyloblepharon filiform http://purl.obolibrary.org/obo/MP_0001340 abnormal eyelid morphology abnormal connection of the upper and lower eyelids formed by fibrous tissue http://purl.obolibrary.org/obo/MP_0006164 ectropion http://purl.obolibrary.org/obo/MP_0001340 abnormal eyelid morphology abnormal eversion of the upper or lower eyelid that leaves the eye exposed and dry http://purl.obolibrary.org/obo/MP_0006165 entropion http://purl.obolibrary.org/obo/MP_0001340 abnormal eyelid morphology abnormal inward rolling of the eyelid, most commonly the lower lid http://purl.obolibrary.org/obo/MP_0006166 eyelid retraction http://purl.obolibrary.org/obo/MP_0003671 abnormal eyelid aperture eyelids open abnormally wide http://purl.obolibrary.org/obo/MP_0006167 eyelid edema http://purl.obolibrary.org/obo/MP_0001785 edema an abnormal accumulation of fluid in the eyelid http://purl.obolibrary.org/obo/MP_0006168 epicanthus inversus http://purl.obolibrary.org/obo/MP_0001340 abnormal eyelid morphology a vertical fold of skin runs from the lower eyelid up either side of the nose http://purl.obolibrary.org/obo/MP_0006169 increased eyelid tumor incidence http://purl.obolibrary.org/obo/MP_0008018 increased facial tumor incidence greater than the expected number of abnormal rapidly proliferating cells in the eyelid, usually in the form of a distinct mass, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0006170 increased eyelid myxoma incidence http://purl.obolibrary.org/obo/MP_0006169 increased eyelid tumor incidence higher than normal incidence of a benign neoplasm derived from pluripotential mesenchymal stem cells of eyelid connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix http://purl.obolibrary.org/obo/MP_0006171 increased eyelid neuroma incidence http://purl.obolibrary.org/obo/MP_0006169 increased eyelid tumor incidence greater than the expected number of a tumor composed of nerve tissue found in the eyelid, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0006172 increased eyelid lipodermoid incidence http://purl.obolibrary.org/obo/MP_0006169 increased eyelid tumor incidence greater than the expected number of a congenital, yellowish-white, fatty, benign tumor located beneath the conjunctiva of the eye, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0006173 abnormal myeloid dendritic cell morphology http://purl.obolibrary.org/obo/MP_0008248 abnormal mononuclear phagocyte morphology any structural anomaly of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses http://purl.obolibrary.org/obo/MP_0006175 choroid atrophy http://purl.obolibrary.org/obo/MP_0005098 abnormal optic choroid morphology acquired diminution of the size of the choroid associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0006176 choroid degeneration http://purl.obolibrary.org/obo/MP_0005098 abnormal optic choroid morphology a retrogressive impairment of function or destruction of the choroid http://purl.obolibrary.org/obo/MP_0006177 choroid sclerosis http://purl.obolibrary.org/obo/MP_0005098 abnormal optic choroid morphology thickening or hardening of the choroid usually secondary to atrophy http://purl.obolibrary.org/obo/MP_0006180 increased choroid hemangioma incidence http://purl.obolibrary.org/obo/MP_0010304 increased choroid tumor incidence greater than the expected number of a benign tumor characterized by blood-filled spaces lined by benign endothelial cells in the choroid, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0006182 increased retinal hemangioma incidence http://purl.obolibrary.org/obo/MP_0010303 increased retina tumor incidence greater than the expected number of a benign tumor characterized by blood-filled spaces lined by benign endothelial cells in the retina, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0006183 increased retina hamartoma incidence http://purl.obolibrary.org/obo/MP_0010303 increased retina tumor incidence greater than the expected number of a benign formation of a mass of tissue of disproportionate size and distribution in the retina, occurring in a specific population in a given time period; hamartomas are typically composed of an overgrowth of mature cells and tissues that normally occur in this tissue http://purl.obolibrary.org/obo/MP_0006184 increased retinal astrocytoma incidence http://purl.obolibrary.org/obo/MP_0010303 increased retina tumor incidence greater than the expected number of a malignant tumor of nervous tissue composed of well-differentiated astrocytes located in the retina, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0006185 retinal hemorrhage http://purl.obolibrary.org/obo/MP_0006203 eye hemorrhage bleeding into the retina http://purl.obolibrary.org/obo/MP_0006186 retinal fibrosis http://purl.obolibrary.org/obo/MP_0001325 abnormal retina morphology invasion of fibrous connective tissue into the retina, often resulting from inflammation or injury http://purl.obolibrary.org/obo/MP_0006187 retinal deposits http://purl.obolibrary.org/obo/MP_0001325 abnormal retina morphology abnormal accumulation of material on the retina http://purl.obolibrary.org/obo/MP_0006188 calcified retina http://purl.obolibrary.org/obo/MP_0006209 calcified intraocular region pathologic deposition of calcium salts in the retina http://purl.obolibrary.org/obo/MP_0006190 retinal ischemia http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology inadequate blood flow to the retina usually due to functional constriction or obstruction of a blood vessel http://purl.obolibrary.org/obo/MP_0006191 conjunctival deposits http://purl.obolibrary.org/obo/MP_0001310 abnormal conjunctiva morphology abnormal accumulation of material on the conjunctiva http://purl.obolibrary.org/obo/MP_0006192 abnormal conjunctival vasculature morphology http://purl.obolibrary.org/obo/MP_0001614 abnormal blood vessel morphology any structural anomaly of the blood vessel network of the conjunctiva http://purl.obolibrary.org/obo/MP_0006193 conjunctival telangiectasia http://purl.obolibrary.org/obo/MP_0006192 abnormal conjunctival vasculature morphology vascular lesion formed by dilation of a group of small blood vessels in the conjunctiva http://purl.obolibrary.org/obo/MP_0006194 keratoconjunctivitis http://purl.obolibrary.org/obo/MP_0001851 eye inflammation inflammation of the conjunctiva and cornea http://purl.obolibrary.org/obo/MP_0006197 ocular hypotelorism http://purl.obolibrary.org/obo/MP_0001299 abnormal eye distance/ position the distance between the eyes is reduced http://purl.obolibrary.org/obo/MP_0006198 enophthalmos http://purl.obolibrary.org/obo/MP_0001299 abnormal eye distance/ position recession of the eyeball within the orbit http://purl.obolibrary.org/obo/MP_0006199 hypertropia http://purl.obolibrary.org/obo/MP_0001299 abnormal eye distance/ position vertical misalignment between the eyes http://purl.obolibrary.org/obo/MP_0006200 vitreous body deposition http://purl.obolibrary.org/obo/MP_0002699 abnormal vitreous body morphology abnormal accumulation of material in the vitreous body http://purl.obolibrary.org/obo/MP_0006201 vitreous body inflammation http://purl.obolibrary.org/obo/MP_0001851 eye inflammation local accumulation of fluid, plasma proteins, and leukocytes in the vitreous body http://purl.obolibrary.org/obo/MP_0006202 vitreous body hemorrhage http://purl.obolibrary.org/obo/MP_0006203 eye hemorrhage bleeding into the vitreous body http://purl.obolibrary.org/obo/MP_0006203 eye hemorrhage http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology bleeding into the eye http://purl.obolibrary.org/obo/MP_0006204 embryonic lethality before implantation http://purl.obolibrary.org/obo/MP_0013292 embryonic lethality prior to organogenesis death anytime between fertilization and implantation (Mus: E0 to less than E4.5) http://purl.obolibrary.org/obo/MP_0006205 embryonic lethality between implantation and somite formation http://purl.obolibrary.org/obo/MP_0009850 embryonic lethality between implantation and placentation death anytime between the point of implantation and somite formation (Mus: E4.5 to less than E8) http://purl.obolibrary.org/obo/MP_0006206 embryonic lethality between somite formation and embryo turning http://purl.obolibrary.org/obo/MP_0009850 embryonic lethality between implantation and placentation death anytime between somite formation and the initiation of embryo turning (Mus: E8 to less than E9) http://purl.obolibrary.org/obo/MP_0006207 embryonic lethality during organogenesis http://purl.obolibrary.org/obo/MP_0008762 embryonic lethality death anytime between embryo turning and the completion of organogenesis (Mus: E9-9.5 to less than E14) http://purl.obolibrary.org/obo/MP_0006208 lethality throughout fetal growth and development http://purl.obolibrary.org/obo/MP_0010832 lethality during fetal growth through weaning death anytime between the completion of organogenesis and birth (Mus: E14 to approximately E18.5) http://purl.obolibrary.org/obo/MP_0006209 calcified intraocular region http://purl.obolibrary.org/obo/MP_0002092 abnormal eye morphology pathologic deposition of calcium salts in the eye http://purl.obolibrary.org/obo/MP_0006210 abnormal orbit size http://purl.obolibrary.org/obo/MP_0010030 abnormal orbit morphology deviation from the normal size of the orbit http://purl.obolibrary.org/obo/MP_0006211 small orbits http://purl.obolibrary.org/obo/MP_0006210 abnormal orbit size reduced size of the orbits http://purl.obolibrary.org/obo/MP_0006212 large orbits http://purl.obolibrary.org/obo/MP_0006210 abnormal orbit size increased size of the orbits http://purl.obolibrary.org/obo/MP_0006213 shallow orbits http://purl.obolibrary.org/obo/MP_0006210 abnormal orbit size decrease in the depth of the orbit http://purl.obolibrary.org/obo/MP_0006214 asymmetrical orbits http://purl.obolibrary.org/obo/MP_0010030 abnormal orbit morphology loss of bilateral symmetry in the orbits http://purl.obolibrary.org/obo/MP_0006216 abnormal optic disc size http://purl.obolibrary.org/obo/MP_0008259 abnormal optic disc morphology deviation from the normal size of the optic disc http://purl.obolibrary.org/obo/MP_0006217 small optic disc http://purl.obolibrary.org/obo/MP_0006216 abnormal optic disc size reduced size of the optic disc http://purl.obolibrary.org/obo/MP_0006218 large optic disc http://purl.obolibrary.org/obo/MP_0006216 abnormal optic disc size increased size of the optic disc http://purl.obolibrary.org/obo/MP_0006219 optic nerve degeneration http://purl.obolibrary.org/obo/MP_0001330 abnormal optic nerve morphology retrogressive pathologic change of the optic nerve http://purl.obolibrary.org/obo/MP_0006220 optic nerve compression http://purl.obolibrary.org/obo/MP_0001330 abnormal optic nerve morphology constriction of the optic nerve http://purl.obolibrary.org/obo/MP_0006221 optic nerve hypoplasia http://purl.obolibrary.org/obo/MP_0001330 abnormal optic nerve morphology underdevelopment or reduced size, usually due to a reduced number of cells, of the fibers in the optic nerve http://purl.obolibrary.org/obo/MP_0006222 optic neuropathy http://purl.obolibrary.org/obo/MP_0001330 abnormal optic nerve morphology damage of the optic nerve due to a blockage of its blood supply, to nutritional deficiencies, or to toxins http://purl.obolibrary.org/obo/MP_0006223 optic nerve swelling http://purl.obolibrary.org/obo/MP_0001785 edema accumulation of an excessive amount of fluid in the optic nerve; usually associated with an increase in intraocular pressure http://purl.obolibrary.org/obo/MP_0006224 oculomotor apraxia http://purl.obolibrary.org/obo/MP_0001389 abnormal eye movement impaired control of horizontal eye movements http://purl.obolibrary.org/obo/MP_0006225 ocular rupture http://purl.obolibrary.org/obo/MP_0002092 abnormal eye morphology tearing of the tissues of the eye http://purl.obolibrary.org/obo/MP_0006226 iris hypoplasia http://purl.obolibrary.org/obo/MP_0001322 abnormal iris morphology underdevelopment or reduced size of the iris, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0006228 iris atrophy http://purl.obolibrary.org/obo/MP_0001322 abnormal iris morphology acquired diminution of the size of the iris associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0006229 iris inflammation http://purl.obolibrary.org/obo/MP_0001851 eye inflammation local accumulation of fluid, plasma proteins and leukocytes in the iris http://purl.obolibrary.org/obo/MP_0006230 iris stroma hypoplasia http://purl.obolibrary.org/obo/MP_0006226 iris hypoplasia underdevelopment or reduced size of the iris stroma, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0006232 increased Lisch nodule incidence http://purl.obolibrary.org/obo/MP_0010305 increased iris tumor incidence greater than the expected number of benign focal malformations in the iris in a specific population in a given time period; results from faulty iris development, and is composed of an abnormal mixture of tissue elements including melanocytes, or an abnormal proportion of a single element normally present at that site http://purl.obolibrary.org/obo/MP_0006234 iridoschisis http://purl.obolibrary.org/obo/MP_0001322 abnormal iris morphology separation of the anterior iris stroma from the posterior stroma and muscle layers http://purl.obolibrary.org/obo/MP_0006235 polycoria http://purl.obolibrary.org/obo/MP_0001317 abnormal pupil morphology two or more pupils in one iris each with sphincter muscle http://purl.obolibrary.org/obo/MP_0006236 absent Meibomian glands http://purl.obolibrary.org/obo/MP_0005252 abnormal Meibomian gland morphology missing meibomian glands http://purl.obolibrary.org/obo/MP_0006237 abnormal choroid vasculature morphology http://purl.obolibrary.org/obo/MP_0005098 abnormal optic choroid morphology any structural anomaly of the blood vessels of the choroid http://purl.obolibrary.org/obo/MP_0006238 abnormal choriocapillaris morphology http://purl.obolibrary.org/obo/MP_0006237 abnormal choroid vasculature morphology any structural anomaly of the capillaries forming the inner vascular layer of the choroid of the eye http://purl.obolibrary.org/obo/MP_0006239 absent choriocapillaris http://purl.obolibrary.org/obo/MP_0006238 abnormal choriocapillaris morphology missing capillaries forming the inner vascular layer of the choroid of the eye http://purl.obolibrary.org/obo/MP_0006240 anisocoria http://purl.obolibrary.org/obo/MP_0001317 abnormal pupil morphology unequal size of pupils http://purl.obolibrary.org/obo/MP_0006241 abnormal placement of pupils http://purl.obolibrary.org/obo/MP_0001317 abnormal pupil morphology abnormal location of the pupil so that it is not in the center of the iris http://purl.obolibrary.org/obo/MP_0006242 white pupil http://purl.obolibrary.org/obo/MP_0001317 abnormal pupil morphology reflective white mass within the eye that gives the appearance of white pupil http://purl.obolibrary.org/obo/MP_0006243 impaired pupillary reflex http://purl.obolibrary.org/obo/MP_0002638 abnormal pupillary reflex the pupil fails to constrict fully when exposed to bright light http://purl.obolibrary.org/obo/MP_0006244 involuntary contraction of eyelids http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology spasmodic winking caused by the involuntary contraction of an eyelid muscle http://purl.obolibrary.org/obo/MP_0006245 dislocated lens http://purl.obolibrary.org/obo/MP_0001303 abnormal lens morphology the lens is moved out of position because some or all of the supporting ligaments have broken http://purl.obolibrary.org/obo/MP_0006248 lagophthalmos http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology inability to completely close the eye http://purl.obolibrary.org/obo/MP_0006249 phthisis bulbi http://purl.obolibrary.org/obo/MP_0002697 abnormal eye size small, shrunken, malformed eye that usually represents an acquired shrinkage of the eye following trauma, infection, or the end result of eye disease rather than a primary developmental defect http://purl.obolibrary.org/obo/MP_0006250 abnormal line of Schwalbe morphology http://purl.obolibrary.org/obo/MP_0005203 abnormal trabecular meshwork morphology any structural anomaly of the thickened peripheral margin of the vitreous membrane of the cornea http://purl.obolibrary.org/obo/MP_0006251 eyelid apraxia http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology impaired ability to open the eyelids without any gross defect in eyelid morphology http://purl.obolibrary.org/obo/MP_0006252 lateral rectus palsy http://purl.obolibrary.org/obo/MP_0006157 palsy of the eye paralysis of the lateral rectus muscle preventing medially deviated and movement laterally from the midline http://purl.obolibrary.org/obo/MP_0006253 clinodactyly http://purl.obolibrary.org/obo/MP_0002110 abnormal digit morphology abnormal lateral curvature of one or more digits towards or away from each other http://purl.obolibrary.org/obo/MP_0006254 thin cerebral cortex http://purl.obolibrary.org/obo/MP_0000788 abnormal cerebral cortex morphology decreased depth of the mantle covering the surface of the cerebral hemispheres http://purl.obolibrary.org/obo/MP_0006256 abnormal gustatory papillae morphology http://purl.obolibrary.org/obo/MP_0000764 abnormal tongue epithelium morphology any structural anomaly of the papillae that contain taste buds, including the fungiform, foliate, and circumvallate papillae http://purl.obolibrary.org/obo/MP_0006257 abnormal fungiform papillae morphology http://purl.obolibrary.org/obo/MP_0006256 abnormal gustatory papillae morphology any structural anomaly of the mushroom-shaped papillae, which have a single taste bud at the tip, located mostly on the dorsal anterior portion of the tongue http://purl.obolibrary.org/obo/MP_0006258 abnormal circumvallate papillae morphology http://purl.obolibrary.org/obo/MP_0006256 abnormal gustatory papillae morphology any structural anomaly of the large papillae, which have multiple taste buds in the trough surrounding the papillae, located near the base and on the dorsal side of the tongue http://purl.obolibrary.org/obo/MP_0006259 abnormal foliate papillae morphology http://purl.obolibrary.org/obo/MP_0006256 abnormal gustatory papillae morphology any structural anomaly of the papillae located on the sides of the tongue http://purl.obolibrary.org/obo/MP_0006260 abnormal gustatory papillae taste bud morphology http://purl.obolibrary.org/obo/MP_0001002 abnormal taste bud morphology any structural anomaly of the taste buds located on the gustatory papillae, which includes the fungiform, foliate, and circumvallate papillae http://purl.obolibrary.org/obo/MP_0006261 annular pancreas http://purl.obolibrary.org/obo/MP_0001944 abnormal pancreas morphology an abnormal ring or collar of pancreatic tissue that encircles the duodenum http://purl.obolibrary.org/obo/MP_0006262 increased testis tumor incidence http://purl.obolibrary.org/obo/MP_0009590 increased gonad tumor incidence greater than the expected number of abnormal rapidly proliferating cells in the testis, usually in the form of a distinct mass, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0006263 decreased systemic arterial diastolic blood pressure http://purl.obolibrary.org/obo/MP_0002843 decreased systemic arterial blood pressure abnormal decrease in the pressure in the arteries between heart beats when the heart is relaxed http://purl.obolibrary.org/obo/MP_0006264 decreased systemic arterial systolic blood pressure http://purl.obolibrary.org/obo/MP_0002843 decreased systemic arterial blood pressure abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries http://purl.obolibrary.org/obo/MP_0006265 increased pulse pressure http://purl.obolibrary.org/obo/MP_0003882 abnormal pulse pressure increase in the difference between systolic and diastolic blood pressure http://purl.obolibrary.org/obo/MP_0006266 decreased pulse pressure http://purl.obolibrary.org/obo/MP_0003882 abnormal pulse pressure decrease in the difference between systolic and diastolic blood pressure http://purl.obolibrary.org/obo/MP_0006267 abnormal intercalated disc morphology http://purl.obolibrary.org/obo/MP_0000278 abnormal myocardial fiber morphology any structural anomaly in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes; the intercalated discs permit communication between the cells such that there is a sequential contraction of the cells from the bottom of the ventricle to the top, facilitating maximal ejection of blood from the ventricle during contraction http://purl.obolibrary.org/obo/MP_0006268 absent cardiac desmosomes http://purl.obolibrary.org/obo/MP_0000278 abnormal myocardial fiber morphology absence of one type of membrane junctions found within the intercalated discs that provide mechanical integrity and prevent separation of adjacent cells during contraction of cardiac tissue http://purl.obolibrary.org/obo/MP_0006269 abnormal mammary gland growth during pregnancy http://purl.obolibrary.org/obo/MP_0009661 abnormal pregnancy anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation in preparation for lactation http://purl.obolibrary.org/obo/MP_0006270 abnormal mammary gland growth during lactation http://purl.obolibrary.org/obo/MP_0000628 abnormal mammary gland development anomaly in the final stage of mammary growth that occurs during the start of lactation http://purl.obolibrary.org/obo/MP_0006271 abnormal involution of the mammary gland http://purl.obolibrary.org/obo/MP_0000628 abnormal mammary gland development anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost http://purl.obolibrary.org/obo/MP_0006272 abnormal urine organic anion level http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis any change in the amount of organic anions in the urine http://purl.obolibrary.org/obo/MP_0006273 abnormal urine organic cation level http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis any change in the amount of organic cations in the urine http://purl.obolibrary.org/obo/MP_0006274 abnormal urine sodium level http://purl.obolibrary.org/obo/MP_0011977 abnormal sodium ion homeostasis any change in the amount of sodium in the urine http://purl.obolibrary.org/obo/MP_0006277 abnormal parasympathetic nervous system physiology http://purl.obolibrary.org/obo/MP_0006276 abnormal autonomic nervous system physiology any functional anomaly of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and generally acts to conserve resources and restore homeostasis, often with effects reciprocal to the sympathetic nervous system http://purl.obolibrary.org/obo/MP_0006278 aortic aneurysm http://purl.obolibrary.org/obo/MP_0003279 aneurysm a protruding sac formed by the dilation of the wall of the aorta resulting from a weakening of the vessel wall http://purl.obolibrary.org/obo/MP_0006280 abnormal digit development http://purl.obolibrary.org/obo/MP_0006279 abnormal limb development anomaly in the formation of the digits http://purl.obolibrary.org/obo/MP_0006282 abnormal spinal cord dorsal horn morphology http://purl.obolibrary.org/obo/MP_0008503 abnormal spinal cord grey matter morphology any structural anomaly of the pronounced, dorsolaterally oriented ridge of grey matter in each lateral half of the spinal cord http://purl.obolibrary.org/obo/MP_0006283 increased medulloblastoma incidence http://purl.obolibrary.org/obo/MP_0009277 increased brain tumor incidence greater than the expected number of a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0006284 absent hypaxial muscle http://purl.obolibrary.org/obo/MP_0003358 abnormal hypaxial muscle morphology absence of the muscles derived from the lateral myotome and lateral portion of the dermomyotome; these include the thoracic intercostal and abdominal muscles, limb muscles and superficial back muscles, as well as the diaphragm and the tip of the tongue http://purl.obolibrary.org/obo/MP_0006285 absent inner ear http://purl.obolibrary.org/obo/MP_0000026 abnormal inner ear morphology absence of all components of the labyrinth, including the semicircular canals, vestibule and cochlea http://purl.obolibrary.org/obo/MP_0006286 inner ear hypoplasia http://purl.obolibrary.org/obo/MP_0000026 abnormal inner ear morphology underdevelopment or reduced size of inner ear structures, usually due to decreased cell number http://purl.obolibrary.org/obo/MP_0006287 inner ear cysts http://purl.obolibrary.org/obo/MP_0000026 abnormal inner ear morphology abnormal membranous sacs in any component of the labyrinth, including the semicircular canals, vestibule and cochlea http://purl.obolibrary.org/obo/MP_0006288 small otic capsule http://purl.obolibrary.org/obo/MP_0000039 abnormal otic capsule morphology reduced size of the cartilage or bony capsule surrounding the inner ear mechanism http://purl.obolibrary.org/obo/MP_0006289 otic capsule hypoplasia http://purl.obolibrary.org/obo/MP_0006288 small otic capsule underdevelopment or reduced size, usually due to a reduced number of cells, of the cartilage or bony capsule surrounding the inner ear mechanism http://purl.obolibrary.org/obo/MP_0006290 proboscis http://purl.obolibrary.org/obo/MP_0011495 abnormal head shape a long, cylindrical protuberance of the face that, in cyclopia or ethmocephaly, represents the nose http://purl.obolibrary.org/obo/MP_0006291 aprosencephaly http://purl.obolibrary.org/obo/MP_0005157 holoprosencephaly the most severe form of holoprosencephaly where the entire prosencephalon (both telencephalon and diencephalon) fails to develop while the hindbrain is largely preserved http://purl.obolibrary.org/obo/MP_0006292 abnormal nasal placode morphology http://purl.obolibrary.org/obo/MP_0005499 abnormal olfactory system morphology any structural anomaly in the paired ectodermal placodes that come to lie in the bottom of the olfactory pits as the pits are deepened by the growth of the surrounding medial and lateral nasal processes; the nasal placode gives rise to the olfactory epithelium of the nose http://purl.obolibrary.org/obo/MP_0006293 absent nasal placodes http://purl.obolibrary.org/obo/MP_0006292 abnormal nasal placode morphology absence of the paired ectodermal placodes that come to lie in the bottom of the olfactory pits as the pits are deepened by the growth of the surrounding medial and lateral nasal processes; the nasal placode gives rise to the olfactory epithelium of the nose http://purl.obolibrary.org/obo/MP_0006294 absent optic vesicle http://purl.obolibrary.org/obo/MP_0003425 abnormal optic vesicle formation absence of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop http://purl.obolibrary.org/obo/MP_0006295 absent sclerotome http://purl.obolibrary.org/obo/MP_0006029 abnormal sclerotome morphology absence of the group of mesenchymal cells that emerge from the ventromedial part of a somite and migrate toward the notochord to give rise to the ribs and vertebrae http://purl.obolibrary.org/obo/MP_0006296 arachnodactyly http://purl.obolibrary.org/obo/MP_0002110 abnormal digit morphology the digits are abnormally long and slender http://purl.obolibrary.org/obo/MP_0006298 abnormal platelet activation http://purl.obolibrary.org/obo/MP_0005464 abnormal platelet physiology anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug http://purl.obolibrary.org/obo/MP_0006299 abnormal latent inhibition of conditioning behavior http://purl.obolibrary.org/obo/MP_0002062 abnormal associative learning anomaly in the impairment in a conditioned response seen after repeated unpaired presentations of the conditioned stimulus prior to pairing it with the unconditioned stimulus http://purl.obolibrary.org/obo/MP_0006300 abnormal entorhinal cortex morphology http://purl.obolibrary.org/obo/MP_0004168 abnormal parahippocampal gyrus morphology any structural anomaly of the structure in the anterior parahippocampus that lies forward of the parahippocampal cortex and immediately medial to the perirhinal cortex, bounded superiorly by the hippocampus and inferiorly by the collateral sulcus http://purl.obolibrary.org/obo/MP_0006301 abnormal mesenchyme morphology http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology any structural anomaly of the loosely packed, unspecialized cells that derive mostly from the mesoderm and contribute to connective tissue, bone, cartilage and circulatory and lymphatic systems http://purl.obolibrary.org/obo/MP_0006302 abnormal ectomesenchyme morphology http://purl.obolibrary.org/obo/MP_0006301 abnormal mesenchyme morphology any structural anomaly in the mesenchymal cells derived from neural crest cells that contribute to development of the hard and soft tissue in the head and neck, including the branchial arches http://purl.obolibrary.org/obo/MP_0006303 abnormal retinal nerve fiber layer morphology http://purl.obolibrary.org/obo/MP_0006069 abnormal retinal neuronal layer morphology any structural anomaly of the layer of the retina formed by expansion of the fibers of the optic nerve http://purl.obolibrary.org/obo/MP_0006305 abnormal optic eminence morphology http://purl.obolibrary.org/obo/MP_0001286 abnormal eye development any structural anomaly of the embryonic structure that gives rise to the corneal ectoderm http://purl.obolibrary.org/obo/MP_0006306 abnormal nasal pit morphology http://purl.obolibrary.org/obo/MP_0003935 abnormal craniofacial development any structural anomaly of one or both of a pair of depressions formed in the developing face that give rise to the rostral portion of the nasal meatus; the nasal pits indent the fronto-nasal process and divide it into a medial and two lateral nasal processes http://purl.obolibrary.org/obo/MP_0006308 enlarged seminiferous tubules http://purl.obolibrary.org/obo/MP_0006307 abnormal seminiferous tubule size increased diameter of the tubules in the testes where spermatogenesis occurs http://purl.obolibrary.org/obo/MP_0006309 decreased retinal ganglion cell number http://purl.obolibrary.org/obo/MP_0008056 abnormal retinal ganglion cell morphology reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain http://purl.obolibrary.org/obo/MP_0006310 increased retinoblastoma incidence http://purl.obolibrary.org/obo/MP_0010303 increased retina tumor incidence higher than normal incidence of a malignant tumor of the retina composed of cells arising from the retinoblasts http://purl.obolibrary.org/obo/MP_0006316 increased urine sodium level http://purl.obolibrary.org/obo/MP_0006274 abnormal urine sodium level higher than normal amount of sodium in the urine http://purl.obolibrary.org/obo/MP_0006317 decreased urine sodium level http://purl.obolibrary.org/obo/MP_0006274 abnormal urine sodium level lower than normal amount of sodium in the urine http://purl.obolibrary.org/obo/MP_0006319 abnormal epididymal fat pad morphology http://purl.obolibrary.org/obo/MP_0000010 abnormal abdominal fat pad morphology any structural anomaly of the encapsulated adipose tissue associated with the epididymis http://purl.obolibrary.org/obo/MP_0006320 abnormal interscapular fat pad morphology http://purl.obolibrary.org/obo/MP_0005334 abnormal fat pad morphology any structural anomaly of the encapsulated adipose tissue located between the scapulae http://purl.obolibrary.org/obo/MP_0006321 increased myocardial fiber number http://purl.obolibrary.org/obo/MP_0000278 abnormal myocardial fiber morphology increased number of the terminally differentiated, non-proliferative, cardiac muscle fibers, the multinucleated muscle cells of the heart http://purl.obolibrary.org/obo/MP_0006322 abnormal perichondrium morphology http://purl.obolibrary.org/obo/MP_0005508 abnormal skeleton morphology any structural anomaly of the fibrous connective tissue that surrounds all non-joint end cartilage http://purl.obolibrary.org/obo/MP_0006323 abnormal extraembryonic mesoderm development http://purl.obolibrary.org/obo/MP_0002086 abnormal extraembryonic tissue morphology malformation of the mesoderm of the extraembryonic tissue that is involved in forming the amnion, chorion, yolk sac, and body stalk http://purl.obolibrary.org/obo/MP_0006324 abnormal cochlear nerve fiber response http://purl.obolibrary.org/obo/MP_0006335 abnormal hearing electrophysiology anomaly in the electrophysiological recordings from a single or several auditory nerve fiber(s) http://purl.obolibrary.org/obo/MP_0006326 conductive hearing impairment http://purl.obolibrary.org/obo/MP_0006325 impaired hearing reduction in the ability to hear due to lesions in the external auditory canal or middle ear http://purl.obolibrary.org/obo/MP_0006327 mixed hearing impairment http://purl.obolibrary.org/obo/MP_0006325 impaired hearing reduced ability to hear resulting from a combination of conductive and sensorineural hearing impairment http://purl.obolibrary.org/obo/MP_0006328 nonsyndromic hearing impairment http://purl.obolibrary.org/obo/MP_0006325 impaired hearing a form of hearing impairment that is not associated with visible abnormalities of the external ear or other signs and symptoms; the vast majority of hereditary hearing loss is nonsyndromic and can be associated with abnormalities of the middle ear and/or inner ear http://purl.obolibrary.org/obo/MP_0006329 sensorineural hearing impairment http://purl.obolibrary.org/obo/MP_0006325 impaired hearing a form of hearing impairment due to a lesion of the auditory division of cranial nerve VIII or the inner ear http://purl.obolibrary.org/obo/MP_0006330 syndromic hearing impairment http://purl.obolibrary.org/obo/MP_0006325 impaired hearing hearing impairment that is usually associated with malformations of the external ear and other inherited signs and symptoms http://purl.obolibrary.org/obo/MP_0006331 abnormal patterning of the organ of Corti http://purl.obolibrary.org/obo/MP_0000042 abnormal organ of Corti morphology anomaly in the organization of the various cell types within the organ of Corti into a set number of distinct rows http://purl.obolibrary.org/obo/MP_0006332 abnormal cochlear potential http://purl.obolibrary.org/obo/MP_0006335 abnormal hearing electrophysiology anomaly in the evoked response of the cochlea http://purl.obolibrary.org/obo/MP_0006334 abnormal susceptibility to hearing loss http://purl.obolibrary.org/obo/MP_0001963 abnormal hearing physiology anomaly in the sensitivity to loss of hearing related to age or environmental factors http://purl.obolibrary.org/obo/MP_0006336 abnormal otoacoustic response http://purl.obolibrary.org/obo/MP_0001963 abnormal hearing physiology anomaly in the acoustic energy produced by the cochlea in the presence or absence of sound stimulation http://purl.obolibrary.org/obo/MP_0006337 abnormal first pharyngeal arch morphology http://purl.obolibrary.org/obo/MP_0002884 abnormal pharyngeal arch morphology any structural anomaly of the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel's cartilage, trigeminal nerve, and maxillary artery http://purl.obolibrary.org/obo/MP_0006338 abnormal second pharyngeal arch morphology http://purl.obolibrary.org/obo/MP_0002884 abnormal pharyngeal arch morphology any structural anomaly of the second arch which contributes to the development of the stapes, styloid process, hyoid bone, stylohyoid ligament, muscles of facial expression, stapedius muscle, stylohyoid muscle, and lining of the palatine tonsils http://purl.obolibrary.org/obo/MP_0006339 abnormal third pharyngeal arch morphology http://purl.obolibrary.org/obo/MP_0002884 abnormal pharyngeal arch morphology any structural anomaly of the third are which contributes to the development of the hyoid bone, stylopharyngeus muscle, inferior parathyroid gland, and thymus http://purl.obolibrary.org/obo/MP_0006340 abnormal fourth pharyngeal arch morphology http://purl.obolibrary.org/obo/MP_0002884 abnormal pharyngeal arch morphology any structural anomaly of the fourth arch which contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus http://purl.obolibrary.org/obo/MP_0006341 small first pharyngeal arch http://purl.obolibrary.org/obo/MP_0006337 abnormal first pharyngeal arch morphology reduced size of the first branchial arch http://purl.obolibrary.org/obo/MP_0006342 absent first pharyngeal arch http://purl.obolibrary.org/obo/MP_0006337 abnormal first pharyngeal arch morphology absence of the structure of the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel's cartilage, trigeminal nerve, and maxillary artery http://purl.obolibrary.org/obo/MP_0006343 enlarged first pharyngeal arch http://purl.obolibrary.org/obo/MP_0006337 abnormal first pharyngeal arch morphology increased size of the first branchial arch http://purl.obolibrary.org/obo/MP_0006344 small second pharyngeal arch http://purl.obolibrary.org/obo/MP_0006338 abnormal second pharyngeal arch morphology reduced size of the second branchial arch http://purl.obolibrary.org/obo/MP_0006345 absent second pharyngeal arch http://purl.obolibrary.org/obo/MP_0006338 abnormal second pharyngeal arch morphology absence of the structure of the second arch which contributes to the development of the stapes, styloid process, hyoid bone, stylohyoid ligament, muscles of facial expression, stapedius muscle, stylohyoid muscle, and lining of the palatine tonsils http://purl.obolibrary.org/obo/MP_0006347 abnormal sixth pharyngeal arch morphology http://purl.obolibrary.org/obo/MP_0002884 abnormal pharyngeal arch morphology any structural anomaly of the sixth arch which contributes to the development of the sternocleidomastoid and trapezius muscles http://purl.obolibrary.org/obo/MP_0006348 abnormal circulating copper level http://purl.obolibrary.org/obo/MP_0006357 abnormal circulating mineral level any anomaly in the blood concentration of copper http://purl.obolibrary.org/obo/MP_0006349 decreased circulating copper level http://purl.obolibrary.org/obo/MP_0006348 abnormal circulating copper level less than the normal concentration of copper in the blood http://purl.obolibrary.org/obo/MP_0006350 increased circulating copper level http://purl.obolibrary.org/obo/MP_0006348 abnormal circulating copper level greater than normal concentration of copper in the blood http://purl.obolibrary.org/obo/MP_0006351 abnormal glycosylated hemoglobin level http://purl.obolibrary.org/obo/MP_0005563 abnormal hemoglobin content aberrant concentration in the blood of modified form of hemoglobin with an attached saccharide molecule; this is commonly used to estimate blood glucose levels over the lifespan of the red blood cell http://purl.obolibrary.org/obo/MP_0006352 decreased glycosylated hemoglobin level http://purl.obolibrary.org/obo/MP_0006351 abnormal glycosylated hemoglobin level lower than normal blood concentration of a modified form of hemoglobin with an attached saccharide molecule http://purl.obolibrary.org/obo/MP_0006353 increased glycosylated hemoglobin level http://purl.obolibrary.org/obo/MP_0006351 abnormal glycosylated hemoglobin level greater than normal blood concentration of a modified form of hemoglobin with an attached saccharide molecule http://purl.obolibrary.org/obo/MP_0006354 abnormal fourth pharyngeal arch artery morphology http://purl.obolibrary.org/obo/MP_0006340 abnormal fourth pharyngeal arch morphology any structural anomaly of the vessels formed within the fourth pair of branchial arches in embryogenesis http://purl.obolibrary.org/obo/MP_0006355 abnormal sixth pharyngeal arch artery morphology http://purl.obolibrary.org/obo/MP_0006347 abnormal sixth pharyngeal arch morphology any structural anomaly of the vessels formed within the sixth pair of branchial arches in embryogenesis http://purl.obolibrary.org/obo/MP_0006356 abnormal third pharyngeal arch artery morphology http://purl.obolibrary.org/obo/MP_0006339 abnormal third pharyngeal arch morphology any structural anomaly of the vessels formed within the third pair of branchial arches in embryogenesis http://purl.obolibrary.org/obo/MP_0006358 absent pinna reflex http://purl.obolibrary.org/obo/MP_0001485 abnormal pinna reflex complete failure to respond to an auditory stimulus by a characteristic ear twitch http://purl.obolibrary.org/obo/MP_0006359 absent startle reflex http://purl.obolibrary.org/obo/MP_0001486 abnormal startle reflex failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch http://purl.obolibrary.org/obo/MP_0006362 abnormal male germ cell morphology http://purl.obolibrary.org/obo/MP_0002208 abnormal germ cell morphology any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated http://purl.obolibrary.org/obo/MP_0006363 absent auchene hairs http://purl.obolibrary.org/obo/MP_0000405 abnormal auchene hair morphology absence of truncal hairs having a single constriction and bend about midway along the hair shaft, and contain two or more air cells in the medulla http://purl.obolibrary.org/obo/MP_0006364 absent awl hair http://purl.obolibrary.org/obo/MP_0000400 abnormal awl hair morphology absence of truncal hairs that are straight, but are shorter than guard hairs, and contain two or more air cells in the medulla http://purl.obolibrary.org/obo/MP_0006365 absent guard hair http://purl.obolibrary.org/obo/MP_0000397 abnormal guard hair morphology absence of the long, straight truncal hairs that contain two air cells in the medulla http://purl.obolibrary.org/obo/MP_0006366 absent zigzag hairs http://purl.obolibrary.org/obo/MP_0000402 abnormal zigzag hair morphology absence of the truncal hairs that have two or more sharp bends with diameter constrictions at the bends, and contain one air cell in the medulla http://purl.obolibrary.org/obo/MP_0006367 absent sweat gland http://purl.obolibrary.org/obo/MP_0000674 abnormal sweat gland morphology absence of any of the coil glands of the skin that secrete sweat http://purl.obolibrary.org/obo/MP_0006369 supernumerary incisors http://purl.obolibrary.org/obo/MP_0005358 abnormal incisor morphology more than the usual number of incisors, normally consisting of two pairs, top and bottom, of the long teeth that are the most anterior and prominent in the jaw http://purl.obolibrary.org/obo/MP_0006370 abnormal hair follicle pheomelanosome pheomelanin content http://purl.obolibrary.org/obo/MP_0013316 abnormal pheomelanosome pheomelanin content anomaly in the amount or distribution of yellow pigment in the hair follicle http://purl.obolibrary.org/obo/MP_0006371 absent hair follicle pheomelanosome pheomelanin http://purl.obolibrary.org/obo/MP_0006370 abnormal hair follicle pheomelanosome pheomelanin content yellow pigment is not present in pheomelanosomes of the hair follicle http://purl.obolibrary.org/obo/MP_0006372 impaired placental function http://purl.obolibrary.org/obo/MP_0010038 abnormal placenta physiology reduction in the ability of the placenta to supply nutrients or remove waste http://purl.obolibrary.org/obo/MP_0006373 abnormal circulating angiotensinogen level http://purl.obolibrary.org/obo/MP_0005416 abnormal circulating protein level anomaly in the concentration of the serum globulin formed by the liver that is cleaved by renin to form angiotensin I http://purl.obolibrary.org/obo/MP_0006375 increased circulating angiotensinogen level http://purl.obolibrary.org/obo/MP_0006373 abnormal circulating angiotensinogen level greater than normal concentration of the serum globulin formed by the liver that is cleaved by renin to form angiotensin I http://purl.obolibrary.org/obo/MP_0006376 decreased circulating angiotensinogen level http://purl.obolibrary.org/obo/MP_0006373 abnormal circulating angiotensinogen level less than normal concentration of the serum globulin formed by the liver that is cleaved by renin to form angiotensin I http://purl.obolibrary.org/obo/MP_0006377 abnormal vestibulocollic reflex http://purl.obolibrary.org/obo/MP_0004742 abnormal vestibular system physiology any anomaly in the neural reflex which results from activation of afferents from the vestibular organs and uses neck movements to stabilize the head position in space http://purl.obolibrary.org/obo/MP_0006378 abnormal spermatogonia morphology http://purl.obolibrary.org/obo/MP_0006362 abnormal male germ cell morphology any structural anomaly of the large unspecialized male germ cells that give rise to spermatocytes http://purl.obolibrary.org/obo/MP_0006379 abnormal spermatocyte morphology http://purl.obolibrary.org/obo/MP_0006362 abnormal male germ cell morphology any structural anomaly of male germ cells that through meiosis give rise to spermatids http://purl.obolibrary.org/obo/MP_0006380 abnormal spermatid morphology http://purl.obolibrary.org/obo/MP_0006362 abnormal male germ cell morphology any structural anomaly of the male germ cells that without further cell division give rise to mature spermatozoa http://purl.obolibrary.org/obo/MP_0006382 abnormal lung epithelium morphology http://purl.obolibrary.org/obo/MP_0010942 abnormal respiratory epithelium morphology any structural anomaly of the epithelial layer of the lung http://purl.obolibrary.org/obo/MP_0006383 abnormal cochlear frequency tuning http://purl.obolibrary.org/obo/MP_0006335 abnormal hearing electrophysiology any anomaly in the frequency resolution of the cochlea, normally determined by the passive mechanical properties of the basilar membrane and active feedback from the outer hair cells which detect and amplify sound-induced basilar membrane motions http://purl.obolibrary.org/obo/MP_0006384 enhanced cochlear frequency tuning http://purl.obolibrary.org/obo/MP_0006383 abnormal cochlear frequency tuning increase in the sharpness of frequency resolution of the cochlea http://purl.obolibrary.org/obo/MP_0006386 absent somites http://purl.obolibrary.org/obo/MP_0001690 failure of somite differentiation absence of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo http://purl.obolibrary.org/obo/MP_0006388 abnormal auditory summating potential http://purl.obolibrary.org/obo/MP_0006335 abnormal hearing electrophysiology any anomaly in the dc shift in the waveform sustained for the duration of a toneburst stimulus that represents the depolarization of sensory hair cells in the cochlea; positive summating potentials (SPs) reflect activity of basal turn hair cells while negative SPs are derived from hair cell activity in the apical turn; negative SPs tend to be obtained at low frequencies and low intensities of stimulus, while positive SPs are recorded in response to high frequencies and high intensities http://purl.obolibrary.org/obo/MP_0006389 abnormal vestibular endolymph http://purl.obolibrary.org/obo/MP_0004885 abnormal endolymph change in the normal production (volume) or ionic homeostasis of the fluid contained within the vestibule of the inner ear; unlike cochlear endolymph this fluid does not have a high potential http://purl.obolibrary.org/obo/MP_0006391 abnormal vestibular endolymph ionic homeostasis http://purl.obolibrary.org/obo/MP_0006389 abnormal vestibular endolymph anomaly in the processes involved in the maintenance of an internal equilibrium of charged molecules in the vestibular endolymph http://purl.obolibrary.org/obo/MP_0006392 abnormal nucleus pulposus morphology http://purl.obolibrary.org/obo/MP_0004173 abnormal intervertebral disk morphology any structural anomaly of the jelly-like substance in the middle of the spinal disc which is a remnant of the notochord http://purl.obolibrary.org/obo/MP_0006393 absent nucleus pulposus http://purl.obolibrary.org/obo/MP_0006392 abnormal nucleus pulposus morphology missing the notochord remnant normally found in the center of the intervertebral disc http://purl.obolibrary.org/obo/MP_0006394 abnormal vertebral epiphyseal plate morphology http://purl.obolibrary.org/obo/MP_0005225 abnormal vertebrae development any structural anomaly of the lateral cartilaginous centers of ossification; may be found on the lateral, upper, and/or lower surfaces of the vertebrae at different times during development http://purl.obolibrary.org/obo/MP_0006396 decreased long bone epiphyseal plate size http://purl.obolibrary.org/obo/MP_0003055 abnormal long bone epiphyseal plate morphology reduced size of the cartilaginous center of ossification located at one or both ends of bones between the epiphysis (end) and the diaphysis (shaft) of long bones; longitudinal growth of the bone occurs at the plate during development in children and juveniles http://purl.obolibrary.org/obo/MP_0006397 disorganized long bone epiphyseal plate http://purl.obolibrary.org/obo/MP_0003055 abnormal long bone epiphyseal plate morphology a lack of the regular arrangement of the cells or zones of the epiphyseal plate http://purl.obolibrary.org/obo/MP_0006398 increased long bone epiphyseal plate size http://purl.obolibrary.org/obo/MP_0003055 abnormal long bone epiphyseal plate morphology greater than the normal size of the cartilaginous center of ossification located at one or both ends of bones between the epiphysis (end) and the diaphysis (shaft) of long bones; longitudinal growth of the bone occurs at the plate during development in children and juveniles http://purl.obolibrary.org/obo/MP_0006399 abnormal long bone epiphyseal ossification zone morphology http://purl.obolibrary.org/obo/MP_0003055 abnormal long bone epiphyseal plate morphology any structural anomaly of the layer of the epiphyseal plate where new bone matrix is deposited http://purl.obolibrary.org/obo/MP_0006400 decreased molar number http://purl.obolibrary.org/obo/MP_0002689 abnormal molar morphology reduction in the number of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface http://purl.obolibrary.org/obo/MP_0006401 absent male preputial gland http://purl.obolibrary.org/obo/MP_0002717 abnormal male preputial gland morphology a lack of the sebaceous glands of the corona and neck of the glans penis http://purl.obolibrary.org/obo/MP_0006402 small molars http://purl.obolibrary.org/obo/MP_0002689 abnormal molar morphology reduced size of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface http://purl.obolibrary.org/obo/MP_0006403 abnormal cochlear endolymph ionic homeostasis http://purl.obolibrary.org/obo/MP_0002630 abnormal endocochlear potential anomaly in the state of equilibrium in the cochlear endolymph with respect to charged molecules; cochlear endolymph is not only an unusual extracellular fluid for its high potassium ion and low sodium ion concentration but also for its low calcium ion concentration, high HCO3- concentration and low protein content http://purl.obolibrary.org/obo/MP_0006405 abnormal L3 dorsal root ganglion morphology http://purl.obolibrary.org/obo/MP_0006404 abnormal lumbar dorsal root ganglion morphology any structural anomaly of the group of nerve cell bodies located on the dorsal spinal roots within the vertebral column at the level of the third lumbar vertebra http://purl.obolibrary.org/obo/MP_0006408 dorsal root ganglion hypoplasia http://purl.obolibrary.org/obo/MP_0000964 small dorsal root ganglion underdevelopment or reduced size, usually due to a reduced cell number, of a dorsal root ganglion or ganglia http://purl.obolibrary.org/obo/MP_0006409 vestibular ganglion hypoplasia http://purl.obolibrary.org/obo/MP_0003987 small vestibular ganglion underdevelopment or reduced size, usually due to a reduced number of cell bodies, in the group of bipolar sensory nerve cell bodies concerned with equilibration that form a swelling on the vestibular part of the eighth cranial nerve in the fundus of the internal acoustic meatus http://purl.obolibrary.org/obo/MP_0006410 abnormal common myeloid progenitor cell morphology http://purl.obolibrary.org/obo/MP_0002398 abnormal bone marrow cell morphology/development any structrual anomaly of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage http://purl.obolibrary.org/obo/MP_0006411 upturned snout http://purl.obolibrary.org/obo/MP_0000443 abnormal snout morphology muzzle has a curve or tilt such that the tip points upwards http://purl.obolibrary.org/obo/MP_0006412 abnormal T cell apoptosis http://purl.obolibrary.org/obo/MP_0002444 abnormal T cell physiology change in the timing or the number of T cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0006413 increased T cell apoptosis http://purl.obolibrary.org/obo/MP_0006412 abnormal T cell apoptosis increase in the number of T cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0006414 decreased T cell apoptosis http://purl.obolibrary.org/obo/MP_0006412 abnormal T cell apoptosis decrease in the number of T cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0006415 absent testes http://purl.obolibrary.org/obo/MP_0005644 agonadal absence of the male reproductive glands containing the germ cells http://purl.obolibrary.org/obo/MP_0006416 abnormal rete testis morphology http://purl.obolibrary.org/obo/MP_0001146 abnormal testis morphology any structural anomaly of the network of canals at the termination of the straight tubules in the mediastinum testis http://purl.obolibrary.org/obo/MP_0006417 rete testis obstruction http://purl.obolibrary.org/obo/MP_0006416 abnormal rete testis morphology any impediment or blockage of the network of canals at the termination of the straight tubules in the mediastinum testis http://purl.obolibrary.org/obo/MP_0006418 abnormal testis cord formation http://purl.obolibrary.org/obo/MP_0003830 abnormal testis development any structural anomaly in the formation of the attachments derived from the primordial seminiferous cords that differentiate into seminiferous tubules in adolescence; defective testis cord formation is most likely to reflect abnormal function of either Sertoli cells or peritubular myoid (PTM) cells which normally cooperate to deposit a layer of basal lamina that defines the edges of individual testis cords http://purl.obolibrary.org/obo/MP_0006419 disorganized testis cords http://purl.obolibrary.org/obo/MP_0006418 abnormal testis cord formation derangement of the pattern of the attachments derived from the primordial seminiferous cords that differentiate into seminiferous tubules in adolescence http://purl.obolibrary.org/obo/MP_0006420 abnormal peritubular myoid cell morphology http://purl.obolibrary.org/obo/MP_0002216 abnormal seminiferous tubule morphology any structural anomaly of the flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule http://purl.obolibrary.org/obo/MP_0006421 decreased number of peritubular myoid cells http://purl.obolibrary.org/obo/MP_0006420 abnormal peritubular myoid cell morphology reduced number of the flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule http://purl.obolibrary.org/obo/MP_0006422 increased mammary adenoacanthoma incidence http://purl.obolibrary.org/obo/MP_0001883 increased mammary adenocarcinoma incidence higher than normal incidence of malignant tumors in which some cells have undergone squamous metaplasia in the mammary gland http://purl.obolibrary.org/obo/MP_0006423 dilated rete testis http://purl.obolibrary.org/obo/MP_0006416 abnormal rete testis morphology an expansion in the volume or area of the network of canals located at the termination of the straight tubules in the mediastinum testis, usually with an increase in contained fluid http://purl.obolibrary.org/obo/MP_0006424 absent testis cords http://purl.obolibrary.org/obo/MP_0006418 abnormal testis cord formation missing the attachments derived from the primordial seminiferous cords that differentiate into seminiferous tubules in adolescence http://purl.obolibrary.org/obo/MP_0006425 absent Mullerian ducts http://purl.obolibrary.org/obo/MP_0003826 abnormal Mullerian duct morphology absence of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina http://purl.obolibrary.org/obo/MP_0006426 Mullerian duct degeneration http://purl.obolibrary.org/obo/MP_0003826 abnormal Mullerian duct morphology a retrogressive impairment of function or destruction of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina http://purl.obolibrary.org/obo/MP_0006427 ectopic Leydig cells http://purl.obolibrary.org/obo/MP_0002786 abnormal Leydig cell morphology abnormal position of the interstitial cells of the seminiferous tubules, which normally reside in the peritubular space and extend from the coelomic surface to the dorsal surface of the gonad http://purl.obolibrary.org/obo/MP_0006428 ectopic Sertoli cells http://purl.obolibrary.org/obo/MP_0002784 abnormal Sertoli cell morphology abnormal position of the supporting cells of the seminiferous tubule epithelium that create the blood-testes barrier and enable spermatogenesis http://purl.obolibrary.org/obo/MP_0006429 abnormal hyaline cartilage morphology http://purl.obolibrary.org/obo/MP_0000163 abnormal cartilage morphology any structural anomaly of the bluish-white, glassy, translucent nonvascular, resilient, flexible connective tissue; found primarily in articular cartilage, costal cartilages, the nasal septum, the larynx, and the trachea http://purl.obolibrary.org/obo/MP_0006430 abnormal elastic cartilage morphology http://purl.obolibrary.org/obo/MP_0000163 abnormal cartilage morphology any structural anomaly of the nonvascular, resilient, flexible connective tissue containing elastin fibers; found primarily in the epiglottis, external ear, and auditory tubes http://purl.obolibrary.org/obo/MP_0006431 abnormal fibrocartilage morphology http://purl.obolibrary.org/obo/MP_0000163 abnormal cartilage morphology any structural anomaly of the nonvascular, resilient, flexible connective tissue containing thick bundles of collagenous fibers; found primarily in intervertebral disks http://purl.obolibrary.org/obo/MP_0006432 abnormal costal cartilage morphology http://purl.obolibrary.org/obo/MP_0004624 abnormal thoracic cage morphology any structural anomaly of the nonvascular, resilient, flexible hyaline connective tissue that connects the end of a true rib to the sternum or the end of a false rib with the with the lower border of the costal cartilage above it http://purl.obolibrary.org/obo/MP_0006433 abnormal articular cartilage morphology http://purl.obolibrary.org/obo/MP_0006429 abnormal hyaline cartilage morphology any structural anomaly of the thin layer of smooth hyaline cartilage located on the joint surfaces of a bone http://purl.obolibrary.org/obo/MP_0008001 hypochlorhydria http://purl.obolibrary.org/obo/MP_0000501 abnormal digestive secretion reduced hydrochloric acid content of the gastric secretions http://purl.obolibrary.org/obo/MP_0008002 hyperchlorhydria http://purl.obolibrary.org/obo/MP_0000501 abnormal digestive secretion increased hydrochloric acid content of the gastric secretions http://purl.obolibrary.org/obo/MP_0008003 achlorhydria http://purl.obolibrary.org/obo/MP_0000501 abnormal digestive secretion absence of hydrochloric acid in the gastric secretions http://purl.obolibrary.org/obo/MP_0008004 abnormal stomach pH http://purl.obolibrary.org/obo/MP_0001663 abnormal digestive system physiology anomaly in the function of the secretory and buffer systems of the stomach that control the relative acidity or alkalinity, as measured by the concentration of the hydrogen ion http://purl.obolibrary.org/obo/MP_0008005 decreased stomach pH http://purl.obolibrary.org/obo/MP_0008004 abnormal stomach pH change in the function of the secretory and buffer systems of the stomach that control the relative acidity or alkalinity, such that the acidity is increased, as indicated by the increased concentration of hydrogen ion http://purl.obolibrary.org/obo/MP_0008006 increased stomach pH http://purl.obolibrary.org/obo/MP_0008004 abnormal stomach pH change in the function of the secretory and buffer systems of the stomach that control the relative acidity or alkalinity, such that the acidity is decreased, as indicated by the decreased concentration of hydrogen ion http://purl.obolibrary.org/obo/MP_0008007 abnormal cellular replicative senescence http://purl.obolibrary.org/obo/MP_0005621 abnormal cell physiology anomaly in the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division http://purl.obolibrary.org/obo/MP_0008008 early cellular replicative senescence http://purl.obolibrary.org/obo/MP_0008007 abnormal cellular replicative senescence increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division http://purl.obolibrary.org/obo/MP_0008009 delayed cellular replicative senescence http://purl.obolibrary.org/obo/MP_0008007 abnormal cellular replicative senescence slower progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division http://purl.obolibrary.org/obo/MP_0008010 increased gastric adenocarcinoma incidence http://purl.obolibrary.org/obo/MP_0010301 increased stomach tumor incidence higher than normal incidence of a malignant neoplasm of epithelial cells in the stomach http://purl.obolibrary.org/obo/MP_0008012 duodenum polyps http://purl.obolibrary.org/obo/MP_0008011 intestine polyps development of numerous growths that are connected to and protrude from the mucous membrane of the duodenum http://purl.obolibrary.org/obo/MP_0008013 cecum polyps http://purl.obolibrary.org/obo/MP_0008011 intestine polyps development of numerous growths that are connected to and protrude from the mucous membrane of the cecum http://purl.obolibrary.org/obo/MP_0008015 abnormal female inguinal canal morphology http://purl.obolibrary.org/obo/MP_0003673 abnormal inguinal canal morphology any structural anomaly of the passage in the lower abdominal wall through which the round ligament, nerves and vessels pass from the pelvic cavity to labia majora http://purl.obolibrary.org/obo/MP_0008016 abnormal male inguinal canal morphology http://purl.obolibrary.org/obo/MP_0003673 abnormal inguinal canal morphology any structural anomaly of the passage in the lower abdominal wall through which the spermatic cord, nerves and vessels pass from the pelvic cavity to the scrotum http://purl.obolibrary.org/obo/MP_0008017 inguinal cysts http://purl.obolibrary.org/obo/MP_0003673 abnormal inguinal canal morphology benign epithelial growths on the walls of the passage in the lower abdominal wall through which the spermatic cord in the male or the round ligament in the female, nerves and vessels pass from the pelvic cavity to the scrotum or labia majora, respectively http://purl.obolibrary.org/obo/MP_0008020 abnormal dermal mast cell morphology http://purl.obolibrary.org/obo/MP_0001243 abnormal dermal layer morphology any structural anomaly of cells located in connective tissue of the dermis that contain numerous basophilic granules and release substances such as heparin and histamine in response to injury or inflammation http://purl.obolibrary.org/obo/MP_0008023 abnormal styloid process morphology http://purl.obolibrary.org/obo/MP_0005272 abnormal temporal bone morphology any structural anomaly in the slender needle-like pointed projection that runs downward and slightly forward from the base of the inferior surface of the petrous portion of the temporal bone where it joins the tympanic portion; it gives attachment to the styloglossus, stylohyoid, and stylopharyngeus muscles and the stylohyoid and stylomandibular ligaments http://purl.obolibrary.org/obo/MP_0008024 absent lymph nodes http://purl.obolibrary.org/obo/MP_0002339 abnormal lymph node morphology absence of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue; these are the sites where acquired immune responses are launched http://purl.obolibrary.org/obo/MP_0008025 brain vacuoles http://purl.obolibrary.org/obo/MP_0002152 abnormal brain morphology the abnormal presence of cavities or fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states http://purl.obolibrary.org/obo/MP_0008027 abnormal spinal cord white matter morphology http://purl.obolibrary.org/obo/MP_0000955 abnormal spinal cord morphology any structural anomaly of the regions of the spinal cord that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites http://purl.obolibrary.org/obo/MP_0008028 pregnancy-related premature death http://purl.obolibrary.org/obo/MP_0002083 premature death death occurring before the normal life span of an organism, occurring during pregnancy, parturition or lactation http://purl.obolibrary.org/obo/MP_0008029 abnormal paraxial mesoderm morphology http://purl.obolibrary.org/obo/MP_0001680 abnormal mesoderm development any structural anomaly of the mesoderm located bilaterally adjacent to the notochord and neural tube; on segmentation, paraxial mesoderm forms the paired somites http://purl.obolibrary.org/obo/MP_0008030 abnormal Cajal-Retzius cell morphology http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology any structural anomaly of the distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus http://purl.obolibrary.org/obo/MP_0008032 abnormal lipolysis http://purl.obolibrary.org/obo/MP_0002118 abnormal lipid homeostasis anomaly in the process of the hydrolysis of fat into free fatty acids http://purl.obolibrary.org/obo/MP_0008033 impaired lipolysis http://purl.obolibrary.org/obo/MP_0008032 abnormal lipolysis reduction in the rate of the hydrolysis of fat into free fatty acids http://purl.obolibrary.org/obo/MP_0008034 enhanced lipolysis http://purl.obolibrary.org/obo/MP_0008032 abnormal lipolysis increase in the rate of the hydrolysis of fat into free fatty acids http://purl.obolibrary.org/obo/MP_0008035 behavioral arrest http://purl.obolibrary.org/obo/MP_0003313 abnormal locomotor activation locomotor activity is interrupted by sudden periods of no movement http://purl.obolibrary.org/obo/MP_0008036 abnormal NK T cell morphology http://purl.obolibrary.org/obo/MP_0008037 abnormal T cell morphology any structural anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments http://purl.obolibrary.org/obo/MP_0008038 abnormal NK T cell number http://purl.obolibrary.org/obo/MP_0008036 abnormal NK T cell morphology deviation from the normal number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments http://purl.obolibrary.org/obo/MP_0008039 increased NK T cell number http://purl.obolibrary.org/obo/MP_0008038 abnormal NK T cell number greater number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments http://purl.obolibrary.org/obo/MP_0008040 decreased NK T cell number http://purl.obolibrary.org/obo/MP_0008038 abnormal NK T cell number reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments http://purl.obolibrary.org/obo/MP_0008041 absent NK T cells http://purl.obolibrary.org/obo/MP_0008070 absent T cells absence of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments http://purl.obolibrary.org/obo/MP_0008042 abnormal NK T cell physiology http://purl.obolibrary.org/obo/MP_0002444 abnormal T cell physiology any functional anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments http://purl.obolibrary.org/obo/MP_0008043 abnormal NK cell number http://purl.obolibrary.org/obo/MP_0005068 abnormal NK cell morphology deviation in the number of lymphocytes that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells http://purl.obolibrary.org/obo/MP_0008044 increased NK cell number http://purl.obolibrary.org/obo/MP_0008043 abnormal NK cell number greater number of lymphocytes that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells http://purl.obolibrary.org/obo/MP_0008045 decreased NK cell number http://purl.obolibrary.org/obo/MP_0008043 abnormal NK cell number reduction in the number of lymphocytes that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells http://purl.obolibrary.org/obo/MP_0008046 absent NK cells http://purl.obolibrary.org/obo/MP_0008045 decreased NK cell number absence of lymphocytes that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells http://purl.obolibrary.org/obo/MP_0008047 absent uterine NK cells http://purl.obolibrary.org/obo/MP_0008876 decreased uterine NK cell number absence of a natural killer cell subset that is found in the decidual of the uterus, is CD56-high, Galectin-1-positive and CD16-negative, and is the most abundant immune cell type in the decidual during the first trimester of pregnancy http://purl.obolibrary.org/obo/MP_0008048 abnormal memory T cell number http://purl.obolibrary.org/obo/MP_0010833 abnormal memory T cell morphology deviation from the normal number of distinctly differentiated long-lived T cells that have the phenotype CD45RO-positive and CD127-positive http://purl.obolibrary.org/obo/MP_0008049 increased memory T cell number http://purl.obolibrary.org/obo/MP_0008048 abnormal memory T cell number increase in the number of distinctly differentiated long-lived T cells that have the phenotype CD45RO-positive and CD127-positive http://purl.obolibrary.org/obo/MP_0008050 decreased memory T cell number http://purl.obolibrary.org/obo/MP_0008048 abnormal memory T cell number reduction in the number of distinctly differentiated long-lived T cells that have the phenotype CD45RO-positive and CD127-positive http://purl.obolibrary.org/obo/MP_0008051 abnormal memory T cell physiology http://purl.obolibrary.org/obo/MP_0002444 abnormal T cell physiology any functional anomaly of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response http://purl.obolibrary.org/obo/MP_0008053 abnormal NK cell differentiation http://purl.obolibrary.org/obo/MP_0005068 abnormal NK cell morphology atypical production of or inability to produce mature lymphocytes that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells http://purl.obolibrary.org/obo/MP_0008054 abnormal uterine NK cell morphology http://purl.obolibrary.org/obo/MP_0010776 abnormal placenta metrial gland morphology any structural anomaly of a natural killer cell subset that is found in the decidual of the uterus, is CD56-high, Galectin-1-positive and CD16-negative, and is the most abundant immune cell type in the decidual during the first trimester of pregnancy http://purl.obolibrary.org/obo/MP_0008055 increased urine osmolality http://purl.obolibrary.org/obo/MP_0002987 abnormal urine osmolality increase in the amount of ions in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0008057 abnormal DNA replication http://purl.obolibrary.org/obo/MP_0005621 abnormal cell physiology any anomaly in the process whereby new strands of DNA are synthesized http://purl.obolibrary.org/obo/MP_0008058 abnormal DNA repair http://purl.obolibrary.org/obo/MP_0005621 abnormal cell physiology any anomaly in the process of restoring DNA after damage or replication error http://purl.obolibrary.org/obo/MP_0008059 abnormal podocyte foot process morphology http://purl.obolibrary.org/obo/MP_0005326 abnormal podocyte morphology any structural anomaly of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries http://purl.obolibrary.org/obo/MP_0008060 abnormal podocyte slit diaphragm morphology http://purl.obolibrary.org/obo/MP_0008062 abnormal podocyte slit junction morphology any structural anomaly of the thin membrane that covers the podocyte filtration slit which allows small molecules such as water, glucose, and ionic salts to pass through while retaining larger macromolecules in the bloodstream http://purl.obolibrary.org/obo/MP_0008061 absent podocyte slit diaphragm http://purl.obolibrary.org/obo/MP_0008060 abnormal podocyte slit diaphragm morphology absence of the thin membrane that covers the podocyte filtration slit which allows small molecules such as water, glucose, and ionic salts to pass through while retaining larger macromolecules in the bloodstream http://purl.obolibrary.org/obo/MP_0008062 abnormal podocyte slit junction morphology http://purl.obolibrary.org/obo/MP_0005326 abnormal podocyte morphology any structural anomaly of the gaps between the interdigitated foot processes of the podocyte http://purl.obolibrary.org/obo/MP_0008063 increased otic epithelium apoptosis http://purl.obolibrary.org/obo/MP_0009806 abnormal otic vesicle morphology increase in the number of otic epithelial cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0008064 decreased otic epithelium proliferation http://purl.obolibrary.org/obo/MP_0009806 abnormal otic vesicle morphology reduction in the expansion rate of the otic epithelial cell population by cell division http://purl.obolibrary.org/obo/MP_0008065 short endolymphatic duct http://purl.obolibrary.org/obo/MP_0008066 small endolymphatic duct length reduction or truncation of the small membranous canal which connects with both saccule and utricle of the membranous labyrinth, passes through the aqueduct of vestibule, and terminates in the endolymphatic sac http://purl.obolibrary.org/obo/MP_0008066 small endolymphatic duct http://purl.obolibrary.org/obo/MP_0006011 abnormal endolymphatic duct morphology reduced size of the small membranous canal which connects with both saccule and utricle of the membranous labyrinth, passes through the aqueduct of vestibule, and terminates in the endolymphatic sac http://purl.obolibrary.org/obo/MP_0008067 retinal ganglion cell degeneration http://purl.obolibrary.org/obo/MP_0008056 abnormal retinal ganglion cell morphology degeneration or loss of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain http://purl.obolibrary.org/obo/MP_0008068 absent retinal ganglion cell http://purl.obolibrary.org/obo/MP_0006309 decreased retinal ganglion cell number absence of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain http://purl.obolibrary.org/obo/MP_0008069 abnormal joint mobility http://purl.obolibrary.org/obo/MP_0001533 abnormal skeleton physiology anomaly in the ability to move joints in a full range of motion and with ease http://purl.obolibrary.org/obo/MP_0008070 absent T cells http://purl.obolibrary.org/obo/MP_0005018 decreased T cell number absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation http://purl.obolibrary.org/obo/MP_0008071 absent B cells http://purl.obolibrary.org/obo/MP_0005017 decreased B cell number absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens http://purl.obolibrary.org/obo/MP_0008072 absent double-negative T cells http://purl.obolibrary.org/obo/MP_0008070 absent T cells absence of the subset of T cells found in the thymus that express neither CD4 nor CD8 http://purl.obolibrary.org/obo/MP_0008073 abnormal CD4-positive, alpha beta T cell number http://purl.obolibrary.org/obo/MP_0012763 abnormal alpha-beta T cell number anomaly in the number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production http://purl.obolibrary.org/obo/MP_0008074 increased CD4-positive, alpha beta T cell number http://purl.obolibrary.org/obo/MP_0012764 increased alpha-beta T cell number greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production http://purl.obolibrary.org/obo/MP_0008076 abnormal CD4-positive T cell differentiation http://purl.obolibrary.org/obo/MP_0002432 abnormal CD4-positive, alpha beta T cell morphology atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production http://purl.obolibrary.org/obo/MP_0008077 abnormal CD8-positive, alpha-beta T cell number http://purl.obolibrary.org/obo/MP_0012763 abnormal alpha-beta T cell number anomaly in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions http://purl.obolibrary.org/obo/MP_0008078 increased CD8-positive, alpha-beta T cell number http://purl.obolibrary.org/obo/MP_0012764 increased alpha-beta T cell number greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions http://purl.obolibrary.org/obo/MP_0008080 abnormal CD8-positive, alpha-beta T cell differentiation http://purl.obolibrary.org/obo/MP_0005010 abnormal CD8-positive, alpha beta T cell morphology atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions http://purl.obolibrary.org/obo/MP_0008081 abnormal single-positive T cell number http://purl.obolibrary.org/obo/MP_0002435 abnormal effector T cell morphology anomaly in the number of T cells bearing either CD4-positive or CD8-positive markers on their surface http://purl.obolibrary.org/obo/MP_0008082 increased single-positive T cell number http://purl.obolibrary.org/obo/MP_0008081 abnormal single-positive T cell number greater number of T cells bearing either CD4 or CD8 markers on their surface http://purl.obolibrary.org/obo/MP_0008083 decreased single-positive T cell number http://purl.obolibrary.org/obo/MP_0008081 abnormal single-positive T cell number reduced number of T cells bearing either CD4 or CD8 markers on their surface http://purl.obolibrary.org/obo/MP_0008085 abnormal T-helper 1 cell number http://purl.obolibrary.org/obo/MP_0008073 abnormal CD4-positive, alpha beta T cell number anomaly in the number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity http://purl.obolibrary.org/obo/MP_0008086 increased T-helper 1 cell number http://purl.obolibrary.org/obo/MP_0008085 abnormal T-helper 1 cell number greater number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity http://purl.obolibrary.org/obo/MP_0008087 decreased T helper 1 cell number http://purl.obolibrary.org/obo/MP_0008085 abnormal T-helper 1 cell number reduced number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity http://purl.obolibrary.org/obo/MP_0008088 abnormal T-helper 1 cell differentiation http://purl.obolibrary.org/obo/MP_0008076 abnormal CD4-positive T cell differentiation atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity http://purl.obolibrary.org/obo/MP_0008089 abnormal T-helper 2 cell number http://purl.obolibrary.org/obo/MP_0008073 abnormal CD4-positive, alpha beta T cell number anomaly in the number of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy http://purl.obolibrary.org/obo/MP_0008090 increased T-helper 2 cell number http://purl.obolibrary.org/obo/MP_0008089 abnormal T-helper 2 cell number greater number of the subset of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy http://purl.obolibrary.org/obo/MP_0008091 decreased T-helper 2 cell number http://purl.obolibrary.org/obo/MP_0008089 abnormal T-helper 2 cell number reduction in the number of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy http://purl.obolibrary.org/obo/MP_0008092 abnormal T-helper 2 cell differentiation http://purl.obolibrary.org/obo/MP_0008076 abnormal CD4-positive T cell differentiation atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy http://purl.obolibrary.org/obo/MP_0008093 abnormal memory B cell number http://purl.obolibrary.org/obo/MP_0002458 abnormal B cell number anomaly in the number of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin http://purl.obolibrary.org/obo/MP_0008094 absent memory B cells http://purl.obolibrary.org/obo/MP_0008729 decreased memory B cell number absence of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin http://purl.obolibrary.org/obo/MP_0008095 abnormal memory B cell differentiation http://purl.obolibrary.org/obo/MP_0002440 abnormal memory B cell morphology atypical production of or inability to produce distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin http://purl.obolibrary.org/obo/MP_0008096 abnormal plasma cell number http://purl.obolibrary.org/obo/MP_0002439 abnormal plasma cell morphology anomaly in the number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin http://purl.obolibrary.org/obo/MP_0008097 increased plasma cell number http://purl.obolibrary.org/obo/MP_0008210 increased mature B cell number greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin http://purl.obolibrary.org/obo/MP_0008098 decreased plasma cell number http://purl.obolibrary.org/obo/MP_0008211 decreased mature B cell number reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin http://purl.obolibrary.org/obo/MP_0008099 abnormal plasma cell differentiation http://purl.obolibrary.org/obo/MP_0002439 abnormal plasma cell morphology atypical production of or inability to produce terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin http://purl.obolibrary.org/obo/MP_0008100 absent plasma cells http://purl.obolibrary.org/obo/MP_0008212 absent mature B cells absence of the terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin http://purl.obolibrary.org/obo/MP_0008101 lymph node hypoplasia http://purl.obolibrary.org/obo/MP_0002217 small lymph nodes underdevelopment or reduced size, usually due to a reduced cell number, in the lymph nodes http://purl.obolibrary.org/obo/MP_0008102 lymph node hyperplasia http://purl.obolibrary.org/obo/MP_0000702 enlarged lymph nodes overdevelopment or increased size, usually due to increased cell number, in the lymph nodes http://purl.obolibrary.org/obo/MP_0008103 amacrine cell degeneration http://purl.obolibrary.org/obo/MP_0005240 abnormal amacrine cell morphology a retrogressive impairment or destruction of one of the three types of interneurons found in the inner nuclear layer of the mature retina; they integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer http://purl.obolibrary.org/obo/MP_0008104 abnormal amacrine cell number http://purl.obolibrary.org/obo/MP_0005240 abnormal amacrine cell morphology anomaly in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina; they integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer http://purl.obolibrary.org/obo/MP_0008105 increased amacrine cell number http://purl.obolibrary.org/obo/MP_0008104 abnormal amacrine cell number increase in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina http://purl.obolibrary.org/obo/MP_0008106 decreased amacrine cell number http://purl.obolibrary.org/obo/MP_0008104 abnormal amacrine cell number reduction in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina http://purl.obolibrary.org/obo/MP_0008107 absent horizontal cells http://purl.obolibrary.org/obo/MP_0006068 abnormal horizontal cell morphology absence of the laterally interconnecting neurons in the outer plexiform layer of the retina that connect rods of one part of the retina with cones in another part of the retina http://purl.obolibrary.org/obo/MP_0008108 abnormal small intestinal villus morphology http://purl.obolibrary.org/obo/MP_0000496 abnormal small intestine morphology any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold http://purl.obolibrary.org/obo/MP_0008109 abnormal small intestinal microvillus morphology http://purl.obolibrary.org/obo/MP_0008108 abnormal small intestinal villus morphology any structural anomaly of the additional extensions of the villi of the small intestine which protrude from the apical surface of the epithelial cells lining the villi; the microvilli increase the absorptive surface area of the small intestine by approximately 600-fold http://purl.obolibrary.org/obo/MP_0008112 abnormal monocyte differentiation http://purl.obolibrary.org/obo/MP_0002620 abnormal monocyte morphology atypical production of or inability to produce the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood http://purl.obolibrary.org/obo/MP_0008113 abnormal macrophage differentiation http://purl.obolibrary.org/obo/MP_0002446 abnormal macrophage morphology atypical production of or inability to produce the large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells http://purl.obolibrary.org/obo/MP_0008114 abnormal Kupffer cell morphology http://purl.obolibrary.org/obo/MP_0008989 abnormal liver sinusoid morphology any structural anomaly of the phagocytic macrophages residing on the luminal surface of the hepatic sinusoids http://purl.obolibrary.org/obo/MP_0008115 abnormal dendritic cell differentiation http://purl.obolibrary.org/obo/MP_0005461 abnormal dendritic cell morphology atypical production of or inability to produce a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation http://purl.obolibrary.org/obo/MP_0008117 abnormal Langerhans cell morphology http://purl.obolibrary.org/obo/MP_0006173 abnormal myeloid dendritic cell morphology any structural anomaly of a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus http://purl.obolibrary.org/obo/MP_0008118 absent Langerhans cell http://purl.obolibrary.org/obo/MP_0008119 decreased Langerhans cell number absence of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus http://purl.obolibrary.org/obo/MP_0008119 decreased Langerhans cell number http://purl.obolibrary.org/obo/MP_0013411 abnormal Langerhans cell number reduction in the number of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus http://purl.obolibrary.org/obo/MP_0008120 abnormal myeloid dendritic cell number http://purl.obolibrary.org/obo/MP_0008125 abnormal dendritic cell number anomaly in the number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses http://purl.obolibrary.org/obo/MP_0008121 increased myeloid dendritic cell number http://purl.obolibrary.org/obo/MP_0008126 increased dendritic cell number greater number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses http://purl.obolibrary.org/obo/MP_0008122 decreased myeloid dendritic cell number http://purl.obolibrary.org/obo/MP_0008127 decreased dendritic cell number reduction in the number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses http://purl.obolibrary.org/obo/MP_0008123 abnormal plasmacytoid dendritic cell number http://purl.obolibrary.org/obo/MP_0008125 abnormal dendritic cell number anomaly in the number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli http://purl.obolibrary.org/obo/MP_0008124 decreased plasmacytoid dendritic cell number http://purl.obolibrary.org/obo/MP_0008127 decreased dendritic cell number reduced number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli http://purl.obolibrary.org/obo/MP_0008125 abnormal dendritic cell number http://purl.obolibrary.org/obo/MP_0011180 abnormal hematopoietic cell number anomaly in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation http://purl.obolibrary.org/obo/MP_0008126 increased dendritic cell number http://purl.obolibrary.org/obo/MP_0008125 abnormal dendritic cell number greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation http://purl.obolibrary.org/obo/MP_0008127 decreased dendritic cell number http://purl.obolibrary.org/obo/MP_0008125 abnormal dendritic cell number reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation http://purl.obolibrary.org/obo/MP_0008128 abnormal brain internal capsule morphology http://purl.obolibrary.org/obo/MP_0008026 abnormal brain white matter morphology any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord http://purl.obolibrary.org/obo/MP_0008129 absent brain internal capsule http://purl.obolibrary.org/obo/MP_0008128 abnormal brain internal capsule morphology absence of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord http://purl.obolibrary.org/obo/MP_0008130 abnormal pituitary intermediate lobe morphology http://purl.obolibrary.org/obo/MP_0000633 abnormal pituitary gland morphology any structural anomaly of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults http://purl.obolibrary.org/obo/MP_0008131 abnormal Peyer's patch number http://purl.obolibrary.org/obo/MP_0000696 abnormal Peyer's patch morphology anomaly in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densely packed B cell follicles http://purl.obolibrary.org/obo/MP_0008132 increased Peyer's patch number http://purl.obolibrary.org/obo/MP_0008131 abnormal Peyer's patch number greater number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densely packed B cell follicles http://purl.obolibrary.org/obo/MP_0008133 decreased Peyer's patch number http://purl.obolibrary.org/obo/MP_0008131 abnormal Peyer's patch number reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densely packed B cell follicles http://purl.obolibrary.org/obo/MP_0008134 abnormal Peyer's patch size http://purl.obolibrary.org/obo/MP_0000696 abnormal Peyer's patch morphology anomaly in the size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densely packed B cell follicles http://purl.obolibrary.org/obo/MP_0008135 small Peyer's patches http://purl.obolibrary.org/obo/MP_0008134 abnormal Peyer's patch size reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densely packed B cell follicles http://purl.obolibrary.org/obo/MP_0008136 enlarged Peyer's patches http://purl.obolibrary.org/obo/MP_0008134 abnormal Peyer's patch size increased size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densely packed B cell follicles http://purl.obolibrary.org/obo/MP_0008137 absent podocytes http://purl.obolibrary.org/obo/MP_0005326 abnormal podocyte morphology absence of a modified epithelial cell of the visceral layer of the Bowman capsule in the renal corpuscle; it has a small perikaryon and a number of primary and secondary foot processes that interdigitate with those of other podocytes and are attached to the outer surface of the glomerular capillary basement membrane http://purl.obolibrary.org/obo/MP_0008138 absent podocyte foot process http://purl.obolibrary.org/obo/MP_0008059 abnormal podocyte foot process morphology absence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries http://purl.obolibrary.org/obo/MP_0008139 fused podocyte foot processes http://purl.obolibrary.org/obo/MP_0008059 abnormal podocyte foot process morphology coalescence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries http://purl.obolibrary.org/obo/MP_0008140 podocyte foot process effacement http://purl.obolibrary.org/obo/MP_0008059 abnormal podocyte foot process morphology a podocyte reaction to injury or damage characterized by flattening of foot processes due to gradual simplification of the interdigitating foot process; the whole podocyte looks flat due to retraction, widening, and shortening of the processes of each podocyte while the frequency of filtration slits is reduced, giving the appearance of a continuous cytoplasmic sheet covering the glomerular basement membrane http://purl.obolibrary.org/obo/MP_0008141 decreased small intestinal microvillus size http://purl.obolibrary.org/obo/MP_0008109 abnormal small intestinal microvillus morphology reduced size of the additional extensions of the villi of the small intestine which protrude from the apical surface of the epithelial cells lining the villi; the microvilli increase the absorptive surface area of the small intestine by approximately 600-fold http://purl.obolibrary.org/obo/MP_0008142 decreased small intestinal villus size http://purl.obolibrary.org/obo/MP_0008108 abnormal small intestinal villus morphology reduced size of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold http://purl.obolibrary.org/obo/MP_0008143 abnormal dendrite morphology http://purl.obolibrary.org/obo/MP_0008415 abnormal neurite morphology any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body http://purl.obolibrary.org/obo/MP_0008144 nyctalopia http://purl.obolibrary.org/obo/MP_0002001 blindness decreased ability to see clearly in reduced illumination; often due to a deficiency of vitamin A or to a retinal disorder http://purl.obolibrary.org/obo/MP_0008145 hemeralopia http://purl.obolibrary.org/obo/MP_0002090 abnormal vision reduced ability to see clearly in bright light with night vision remaining unchanged; often due to impaired retinal cone function http://purl.obolibrary.org/obo/MP_0008146 asymmetric rib-sternum attachment http://purl.obolibrary.org/obo/MP_0008148 abnormal rib-sternum attachment loss of bilateral symmetry in rib attachments to the sternum http://purl.obolibrary.org/obo/MP_0008147 asymmetric rib-vertebral column attachment http://purl.obolibrary.org/obo/MP_0008149 abnormal rib-vertebral column attachment loss of bilateral symmetry in rib attachments to the vertebral column http://purl.obolibrary.org/obo/MP_0008148 abnormal rib-sternum attachment http://purl.obolibrary.org/obo/MP_0004625 abnormal rib attachment any anomaly in the in the normal joining of the ribs to the sternum http://purl.obolibrary.org/obo/MP_0008149 abnormal rib-vertebral column attachment http://purl.obolibrary.org/obo/MP_0004703 abnormal vertebral column morphology any anomaly in the in the normal joining of the ribs to the vertebral column http://purl.obolibrary.org/obo/MP_0008150 decreased diameter of long bones http://purl.obolibrary.org/obo/MP_0003723 abnormal long bone morphology reduced width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge http://purl.obolibrary.org/obo/MP_0008151 increased diameter of long bones http://purl.obolibrary.org/obo/MP_0003723 abnormal long bone morphology increased width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge http://purl.obolibrary.org/obo/MP_0008152 decreased diameter of femur http://purl.obolibrary.org/obo/MP_0008150 decreased diameter of long bones reduced width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge http://purl.obolibrary.org/obo/MP_0008153 decreased diameter of fibula http://purl.obolibrary.org/obo/MP_0008150 decreased diameter of long bones reduced width of the cross-sectional distance that extends from one lateral edge of the fibula, through its center and to the opposite lateral edge http://purl.obolibrary.org/obo/MP_0008154 decreased diameter of humerus http://purl.obolibrary.org/obo/MP_0008150 decreased diameter of long bones reduced width of the cross-sectional distance that extends from one lateral edge of the humerus, through its center and to the opposite lateral edge http://purl.obolibrary.org/obo/MP_0008155 decreased diameter of radius http://purl.obolibrary.org/obo/MP_0008150 decreased diameter of long bones reduced width of the cross-sectional distance that extends from one lateral edge of the radius, through its center and to the opposite lateral edge http://purl.obolibrary.org/obo/MP_0008156 decreased diameter of tibia http://purl.obolibrary.org/obo/MP_0008150 decreased diameter of long bones reduced width of the cross-sectional distance that extends from one lateral edge of the tibia, through its center and to the opposite lateral edge http://purl.obolibrary.org/obo/MP_0008157 decreased diameter of ulna http://purl.obolibrary.org/obo/MP_0008150 decreased diameter of long bones reduced width of the cross-sectional distance that extends from one lateral edge of the ulna, through its center and to the opposite lateral edge http://purl.obolibrary.org/obo/MP_0008158 increased diameter of femur http://purl.obolibrary.org/obo/MP_0008151 increased diameter of long bones increased width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge http://purl.obolibrary.org/obo/MP_0008159 increased diameter of fibula http://purl.obolibrary.org/obo/MP_0008151 increased diameter of long bones increased width of the cross-sectional distance that extends from one lateral edge of the fibula, through its center and to the opposite lateral edge http://purl.obolibrary.org/obo/MP_0008160 increased diameter of humerus http://purl.obolibrary.org/obo/MP_0008151 increased diameter of long bones increased width of the cross-sectional distance that extends from one lateral edge of the humerus, through its center and to the opposite lateral edge http://purl.obolibrary.org/obo/MP_0008161 increased diameter of radius http://purl.obolibrary.org/obo/MP_0008151 increased diameter of long bones increased width of the cross-sectional distance that extends from one lateral edge of the radius, through its center and to the opposite lateral edge http://purl.obolibrary.org/obo/MP_0008162 increased diameter of tibia http://purl.obolibrary.org/obo/MP_0008151 increased diameter of long bones increased width of the cross-sectional distance that extends from one lateral edge of the tibia, through its center and to the opposite lateral edge http://purl.obolibrary.org/obo/MP_0008163 increased diameter of ulna http://purl.obolibrary.org/obo/MP_0008151 increased diameter of long bones increased width of the cross-sectional distance that extends from one lateral edge of the ulna, through its center and to the opposite lateral edge http://purl.obolibrary.org/obo/MP_0008164 abnormal B-1a B cell morphology http://purl.obolibrary.org/obo/MP_0004940 abnormal B-1 B cell morphology any structural anomaly of the B-1 B cell subset bearing the CD5 surface marker http://purl.obolibrary.org/obo/MP_0008165 abnormal B-1b B cell morphology http://purl.obolibrary.org/obo/MP_0004940 abnormal B-1 B cell morphology any structural anomaly of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell http://purl.obolibrary.org/obo/MP_0008166 abnormal B-2 B cell morphology http://purl.obolibrary.org/obo/MP_0008171 abnormal mature B cell morphology any structural anomaly of a conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells http://purl.obolibrary.org/obo/MP_0008167 increased B-1a cell number http://purl.obolibrary.org/obo/MP_0008164 abnormal B-1a B cell morphology greater number of the B-1 B cell subset bearing the CD5 surface marker http://purl.obolibrary.org/obo/MP_0008168 decreased B-1a cell number http://purl.obolibrary.org/obo/MP_0008164 abnormal B-1a B cell morphology reduced number of the B-1 B cell subset bearing the CD5 surface marker http://purl.obolibrary.org/obo/MP_0008169 increased B-1b cell number http://purl.obolibrary.org/obo/MP_0008165 abnormal B-1b B cell morphology greater number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell http://purl.obolibrary.org/obo/MP_0008170 decreased B-1b cell number http://purl.obolibrary.org/obo/MP_0008165 abnormal B-1b B cell morphology reduced number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell http://purl.obolibrary.org/obo/MP_0008172 abnormal follicular B cell morphology http://purl.obolibrary.org/obo/MP_0008171 abnormal mature B cell morphology any structural anomaly of a resting mature B cell with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes http://purl.obolibrary.org/obo/MP_0008173 increased follicular B cell number http://purl.obolibrary.org/obo/MP_0008210 increased mature B cell number greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes http://purl.obolibrary.org/obo/MP_0008174 decreased follicular B cell number http://purl.obolibrary.org/obo/MP_0008211 decreased mature B cell number reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes http://purl.obolibrary.org/obo/MP_0008175 absent follicular B cells http://purl.obolibrary.org/obo/MP_0008212 absent mature B cells absence of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes http://purl.obolibrary.org/obo/MP_0008176 abnormal germinal center B cell morphology http://purl.obolibrary.org/obo/MP_0008171 abnormal mature B cell morphology any structural anomaly of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen http://purl.obolibrary.org/obo/MP_0008177 increased germinal center B cell number http://purl.obolibrary.org/obo/MP_0008210 increased mature B cell number greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen http://purl.obolibrary.org/obo/MP_0008178 decreased germinal center B cell number http://purl.obolibrary.org/obo/MP_0008211 decreased mature B cell number reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen http://purl.obolibrary.org/obo/MP_0008179 absent germinal center B cells http://purl.obolibrary.org/obo/MP_0008212 absent mature B cells absence of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen http://purl.obolibrary.org/obo/MP_0008180 abnormal marginal zone B cell morphology http://purl.obolibrary.org/obo/MP_0008171 abnormal mature B cell morphology any structural anomaly of a CD23-negative, CD21-positive B cell of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL http://purl.obolibrary.org/obo/MP_0008181 increased marginal zone B cell number http://purl.obolibrary.org/obo/MP_0008210 increased mature B cell number greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL http://purl.obolibrary.org/obo/MP_0008182 decreased marginal zone B cell number http://purl.obolibrary.org/obo/MP_0008211 decreased mature B cell number reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL http://purl.obolibrary.org/obo/MP_0008183 absent marginal zone B cells http://purl.obolibrary.org/obo/MP_0008212 absent mature B cells absence of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL http://purl.obolibrary.org/obo/MP_0008184 abnormal naive B cell morphology http://purl.obolibrary.org/obo/MP_0008171 abnormal mature B cell morphology any structural anomaly of a mature B cell which has not yet been activated by antigen http://purl.obolibrary.org/obo/MP_0008185 decreased naive B cell number http://purl.obolibrary.org/obo/MP_0008184 abnormal naive B cell morphology reduced number of mature B cells which have not yet been activated by antigen http://purl.obolibrary.org/obo/MP_0008187 absent pro-B cells http://purl.obolibrary.org/obo/MP_0008208 decreased pro-B cell number absence of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs http://purl.obolibrary.org/obo/MP_0008188 abnormal transitional stage B cell morphology http://purl.obolibrary.org/obo/MP_0005022 abnormal immature B cell morphology any structural anomaly of an immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection http://purl.obolibrary.org/obo/MP_0008189 increased transitional stage B cell number http://purl.obolibrary.org/obo/MP_0008214 increased immature B cell number greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection http://purl.obolibrary.org/obo/MP_0008190 decreased transitional stage B cell number http://purl.obolibrary.org/obo/MP_0008215 decreased immature B cell number reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection http://purl.obolibrary.org/obo/MP_0008191 abnormal follicular B cell physiology http://purl.obolibrary.org/obo/MP_0002459 abnormal B cell physiology abnormal function of a resting mature B cell with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen http://purl.obolibrary.org/obo/MP_0008192 abnormal germinal center B cell physiology http://purl.obolibrary.org/obo/MP_0002459 abnormal B cell physiology abnormal function of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes http://purl.obolibrary.org/obo/MP_0008193 abnormal marginal zone B cell physiology http://purl.obolibrary.org/obo/MP_0002459 abnormal B cell physiology abnormal function of a CD23-negative, CD21-positive B cell of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL http://purl.obolibrary.org/obo/MP_0008194 abnormal memory B cell physiology http://purl.obolibrary.org/obo/MP_0002459 abnormal B cell physiology abnormal function of a distinctly differentiated long-lived B cell that is readily activated upon reencounter of its antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin http://purl.obolibrary.org/obo/MP_0008196 abnormal follicular dendritic cell morphology http://purl.obolibrary.org/obo/MP_0000716 abnormal immune system cell morphology any structural anomaly of a cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response http://purl.obolibrary.org/obo/MP_0008197 abnormal follicular dendritic cell physiology http://purl.obolibrary.org/obo/MP_0001819 abnormal immune cell physiology abnormal function of a cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response http://purl.obolibrary.org/obo/MP_0008198 abnormal follicular dendritic cell antigen presentation http://purl.obolibrary.org/obo/MP_0008197 abnormal follicular dendritic cell physiology anomaly in the ability of follicular dendritic cells to process and present antigen to B lymphocytes http://purl.obolibrary.org/obo/MP_0008199 increased follicular dendritic cell number http://purl.obolibrary.org/obo/MP_0008196 abnormal follicular dendritic cell morphology greater number of cells with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response http://purl.obolibrary.org/obo/MP_0008200 decreased follicular dendritic cell number http://purl.obolibrary.org/obo/MP_0008196 abnormal follicular dendritic cell morphology reduced number of cells with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response http://purl.obolibrary.org/obo/MP_0008201 absent follicular dendritic cells http://purl.obolibrary.org/obo/MP_0008200 decreased follicular dendritic cell number absence of cells with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response http://purl.obolibrary.org/obo/MP_0008202 absent B-1 B cells http://purl.obolibrary.org/obo/MP_0008212 absent mature B cells absence of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and are enriched for self-reactivity; B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas http://purl.obolibrary.org/obo/MP_0008203 absent B-1a cells http://purl.obolibrary.org/obo/MP_0008202 absent B-1 B cells absence of the B-1 B cell subset bearing the CD5 surface marker http://purl.obolibrary.org/obo/MP_0008204 absent B-1b cells http://purl.obolibrary.org/obo/MP_0008202 absent B-1 B cells absence of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell http://purl.obolibrary.org/obo/MP_0008205 absent B-2 B cells http://purl.obolibrary.org/obo/MP_0008212 absent mature B cells absence of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells http://purl.obolibrary.org/obo/MP_0008206 increased B-2 B cell number http://purl.obolibrary.org/obo/MP_0008210 increased mature B cell number greater number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells http://purl.obolibrary.org/obo/MP_0008207 decreased B-2 B cell number http://purl.obolibrary.org/obo/MP_0008211 decreased mature B cell number reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells http://purl.obolibrary.org/obo/MP_0008208 decreased pro-B cell number http://purl.obolibrary.org/obo/MP_0005432 abnormal pro-B cell morphology reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs http://purl.obolibrary.org/obo/MP_0008210 increased mature B cell number http://purl.obolibrary.org/obo/MP_0008171 abnormal mature B cell morphology greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex http://purl.obolibrary.org/obo/MP_0008211 decreased mature B cell number http://purl.obolibrary.org/obo/MP_0005017 decreased B cell number reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex http://purl.obolibrary.org/obo/MP_0008212 absent mature B cells http://purl.obolibrary.org/obo/MP_0008211 decreased mature B cell number absence of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex http://purl.obolibrary.org/obo/MP_0008214 increased immature B cell number http://purl.obolibrary.org/obo/MP_0005022 abnormal immature B cell morphology greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity http://purl.obolibrary.org/obo/MP_0008215 decreased immature B cell number http://purl.obolibrary.org/obo/MP_0005022 abnormal immature B cell morphology reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity http://purl.obolibrary.org/obo/MP_0008216 absent transitional stage B cells http://purl.obolibrary.org/obo/MP_0008190 decreased transitional stage B cell number absence of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection http://purl.obolibrary.org/obo/MP_0008217 abnormal B cell activation http://purl.obolibrary.org/obo/MP_0002459 abnormal B cell physiology any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific http://purl.obolibrary.org/obo/MP_0008218 delayed emergence of vibrissae http://purl.obolibrary.org/obo/MP_0002098 abnormal vibrissa morphology eruption of the vibrissae from the skin later than expected http://purl.obolibrary.org/obo/MP_0008220 abnormal ventral commissure morphology http://purl.obolibrary.org/obo/MP_0002199 abnormal brain commissure morphology any structural anomaly of the fiber tracts that connect the ventral region of the two cerebral hemispheres and span the longitudinal fissure, including the anterior and the habenular commissures http://purl.obolibrary.org/obo/MP_0008221 abnormal hippocampal commissure morphology http://purl.obolibrary.org/obo/MP_0008219 abnormal dorsal telencephalic commissure morphology any structural anomaly of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side http://purl.obolibrary.org/obo/MP_0008222 decreased hippocampal commissure size http://purl.obolibrary.org/obo/MP_0008221 abnormal hippocampal commissure morphology reduced size of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side http://purl.obolibrary.org/obo/MP_0008223 absent hippocampal commissure http://purl.obolibrary.org/obo/MP_0008221 abnormal hippocampal commissure morphology absence of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side http://purl.obolibrary.org/obo/MP_0008224 increased hippocampal commissure size http://purl.obolibrary.org/obo/MP_0008221 abnormal hippocampal commissure morphology enlarged triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side http://purl.obolibrary.org/obo/MP_0008225 abnormal anterior commissure morphology http://purl.obolibrary.org/obo/MP_0008220 abnormal ventral commissure morphology any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle http://purl.obolibrary.org/obo/MP_0008226 decreased anterior commissure size http://purl.obolibrary.org/obo/MP_0008225 abnormal anterior commissure morphology reduced size of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle http://purl.obolibrary.org/obo/MP_0008227 absent anterior commissure http://purl.obolibrary.org/obo/MP_0008225 abnormal anterior commissure morphology absence of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle http://purl.obolibrary.org/obo/MP_0008228 increased anterior commissure size http://purl.obolibrary.org/obo/MP_0008225 abnormal anterior commissure morphology enlarged round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle http://purl.obolibrary.org/obo/MP_0008231 abnormal habenular commissure morphology http://purl.obolibrary.org/obo/MP_0008220 abnormal ventral commissure morphology any structural anomaly of the connection between the right and left habenular nuclei; the decussation of fibers of the two striae medullares, forming the dorsal portion of the peduncle of the pineal body http://purl.obolibrary.org/obo/MP_0008232 abnormal cingulum morphology http://purl.obolibrary.org/obo/MP_0008026 abnormal brain white matter morphology any structural anomaly of the white matter fiber bundle that projects from the cingulate gyrus to the entorhinal cortex in the brain http://purl.obolibrary.org/obo/MP_0008233 abnormal pro-B cell differentiation http://purl.obolibrary.org/obo/MP_0005432 abnormal pro-B cell morphology atypical production of or inability to produce the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs http://purl.obolibrary.org/obo/MP_0008234 absent spleen marginal zone http://purl.obolibrary.org/obo/MP_0002362 abnormal spleen marginal zone morphology absence of the zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens http://purl.obolibrary.org/obo/MP_0008235 increased susceptibility to neuronal excitotoxicity http://purl.obolibrary.org/obo/MP_0008873 increased physiological sensitivity to xenobiotic greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kainate-induced neuronal cell death mediated via a glutamate excitotoxic process http://purl.obolibrary.org/obo/MP_0008236 decreased susceptibility to neuronal excitotoxicity http://purl.obolibrary.org/obo/MP_0008874 decreased physiological sensitivity to xenobiotic less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kainate-induced neuronal cell death mediated via a glutamate excitotoxic process http://purl.obolibrary.org/obo/MP_0008237 abnormal ventral coat pigmentation http://purl.obolibrary.org/obo/MP_0002075 abnormal coat/hair pigmentation irregular or unusual pigmentation of ventrum hair in relation to control animals http://purl.obolibrary.org/obo/MP_0008238 abnormal dorsoventral coat patterning http://purl.obolibrary.org/obo/MP_0002075 abnormal coat/hair pigmentation irregular or unusual pigmentation pattern of the dorsal-to-ventral axis compared to control animals http://purl.obolibrary.org/obo/MP_0008240 abnormal spleen marginal zone macrophage morphology http://purl.obolibrary.org/obo/MP_0002446 abnormal macrophage morphology any structural anomaly of the cells present in the splenic marginal zone and are involved in the recognition and clearance of material, such as pathogen-derived material, from the splenic circulation http://purl.obolibrary.org/obo/MP_0008241 abnormal metallophilic macrophage morphology http://purl.obolibrary.org/obo/MP_0002446 abnormal macrophage morphology any structural anomaly of the macrophage cells that surround the white pulp of the spleen, adjacent to the marginal sinus http://purl.obolibrary.org/obo/MP_0008242 abnormal perivascular macrophage morphology http://purl.obolibrary.org/obo/MP_0002446 abnormal macrophage morphology any structural anomaly of macrophages that line the small blood vessels http://purl.obolibrary.org/obo/MP_0008243 abnormal macrophage derived foam cell morphology http://purl.obolibrary.org/obo/MP_0009840 abnormal foam cell morphology any structural anomaly of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions http://purl.obolibrary.org/obo/MP_0008244 abnormal peritoneal macrophage morphology http://purl.obolibrary.org/obo/MP_0002446 abnormal macrophage morphology any structural anomaly of a mononuclear phagocyte that develops from bone marrow precursors but is resident in the peritoneum http://purl.obolibrary.org/obo/MP_0008245 abnormal alveolar macrophage morphology http://purl.obolibrary.org/obo/MP_0010901 abnormal pulmonary alveolar parenchyma morphology any structural anomaly of the round, granular, mononuclear phagocytes found in the alveoli of the lungs which ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells http://purl.obolibrary.org/obo/MP_0008249 abnormal common lymphocyte progenitor cell morphology http://purl.obolibrary.org/obo/MP_0005460 abnormal leukopoiesis any structural anomaly of a progenitor cell committed to the lymphoid lineage http://purl.obolibrary.org/obo/MP_0008251 abnormal phagocyte morphology http://purl.obolibrary.org/obo/MP_0008250 abnormal myeloid leukocyte morphology any structural anomaly of cells capable of ingesting particulate matter via phagocytosis http://purl.obolibrary.org/obo/MP_0008252 abnormal multinucleated phagocyte morphology http://purl.obolibrary.org/obo/MP_0008251 abnormal phagocyte morphology any structural anomaly of a phagocyte formed by the fusion of mononuclear phagocytes http://purl.obolibrary.org/obo/MP_0008253 absent megakaryocytes http://purl.obolibrary.org/obo/MP_0008255 decreased megakaryocyte cell number absence of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm http://purl.obolibrary.org/obo/MP_0008254 increased megakaryocyte cell number http://purl.obolibrary.org/obo/MP_0002417 abnormal megakaryocyte morphology greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm http://purl.obolibrary.org/obo/MP_0008255 decreased megakaryocyte cell number http://purl.obolibrary.org/obo/MP_0002417 abnormal megakaryocyte morphology reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm http://purl.obolibrary.org/obo/MP_0008256 abnormal myometrium morphology http://purl.obolibrary.org/obo/MP_0001120 abnormal uterus morphology any structural anomaly of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium http://purl.obolibrary.org/obo/MP_0008257 thin myometrium http://purl.obolibrary.org/obo/MP_0008256 abnormal myometrium morphology reduced thickness of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium http://purl.obolibrary.org/obo/MP_0008258 thin endometrium http://purl.obolibrary.org/obo/MP_0004896 abnormal endometrium morphology reduced thickness of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy http://purl.obolibrary.org/obo/MP_0008259 abnormal optic disc morphology http://purl.obolibrary.org/obo/MP_0002864 abnormal ocular fundus morphology any structural anomaly of the area in the retina where all of the axons of the ganglion cells exit the retina to form the optic nerve http://purl.obolibrary.org/obo/MP_0008260 abnormal autophagy http://purl.obolibrary.org/obo/MP_0005621 abnormal cell physiology abnormal catabolic process involving the degradation of a cell's own components through the lysosomal machinery http://purl.obolibrary.org/obo/MP_0008261 arrest of male meiosis http://purl.obolibrary.org/obo/MP_0005169 abnormal male meiosis cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell http://purl.obolibrary.org/obo/MP_0008262 abnormal hippocampus region morphology http://purl.obolibrary.org/obo/MP_0000807 abnormal hippocampus morphology any structural anomaly of a part or parts of the hippocampus that have a particular function http://purl.obolibrary.org/obo/MP_0008263 abnormal hippocampus CA1 region morphology http://purl.obolibrary.org/obo/MP_0008262 abnormal hippocampus region morphology any structural anomaly of a cytoarchitectural subregion of the Ammon's horn region of the hippocampal formation consisting primarily of pyramidal neurons; the pyramidal neurons of CA1 receive projections from pyramidal neurons of CA3 via the Schaffer collaterals and send outputs to the entorhinal cortex and to the subiculum http://purl.obolibrary.org/obo/MP_0008265 abnormal hippocampus CA2 region morphology http://purl.obolibrary.org/obo/MP_0008262 abnormal hippocampus region morphology any structural anomaly of the smallest cytoarchitectural subregion of the Ammon's horn region of the hippocampal formation, located between CA3 and CA1, comprised of pyramidal neurons receiving both Schaffer collateral and mossy fiber input http://purl.obolibrary.org/obo/MP_0008269 abnormal hippocampus CA4 region morphology http://purl.obolibrary.org/obo/MP_0008262 abnormal hippocampus region morphology any structural anomaly of the region of the hippocampal formation that is comprised of mossy cells that primarily receive inputs from granule cells in the dentate gyrus in the form of mossy fibers and from pyramidal cells in CA3, and send outputs into the dentate gyrus http://purl.obolibrary.org/obo/MP_0008274 failure of bone ossification http://purl.obolibrary.org/obo/MP_0008271 abnormal bone ossification failure to initiate or a block in the process of the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance http://purl.obolibrary.org/obo/MP_0008275 failure of endochondral bone ossification http://purl.obolibrary.org/obo/MP_0008274 failure of bone ossification failure to initiate or a block in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone http://purl.obolibrary.org/obo/MP_0008276 failure of intramembranous bone ossification http://purl.obolibrary.org/obo/MP_0008274 failure of bone ossification failure to initiate or a block in the process of the formation of bone in which osteoblasts secrete a collage-proteoglycan matrix that binds calcium salts and becomes calcified; intramembranous ossification is the way flat bones are formed http://purl.obolibrary.org/obo/MP_0008277 abnormal sternum ossification http://purl.obolibrary.org/obo/MP_0008272 abnormal endochondral bone ossification anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone http://purl.obolibrary.org/obo/MP_0008278 failure of sternum ossification http://purl.obolibrary.org/obo/MP_0008277 abnormal sternum ossification failure to initiate or a block in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone http://purl.obolibrary.org/obo/MP_0008279 arrest of spermiogenesis http://purl.obolibrary.org/obo/MP_0001932 abnormal spermiogenesis block in the process by which a spermatid transforms into a functional spermatozoon http://purl.obolibrary.org/obo/MP_0008280 abnormal male germ cell apoptosis http://purl.obolibrary.org/obo/MP_0003698 abnormal male reproductive system physiology presence of male germs cells that undergo programmed cell death http://purl.obolibrary.org/obo/MP_0008281 abnormal hippocampus size http://purl.obolibrary.org/obo/MP_0000807 abnormal hippocampus morphology anomaly in the size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation http://purl.obolibrary.org/obo/MP_0008282 enlarged hippocampus http://purl.obolibrary.org/obo/MP_0008281 abnormal hippocampus size increased size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation http://purl.obolibrary.org/obo/MP_0008283 small hippocampus http://purl.obolibrary.org/obo/MP_0008281 abnormal hippocampus size reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation http://purl.obolibrary.org/obo/MP_0008287 abnormal subiculum morphology http://purl.obolibrary.org/obo/MP_0000807 abnormal hippocampus morphology any structural anomaly of the transitional zone between the parahippocampal gyrus and the Ammon gyrus http://purl.obolibrary.org/obo/MP_0008288 abnormal adrenal cortex morphology http://purl.obolibrary.org/obo/MP_0000639 abnormal adrenal gland morphology any structural anomaly of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone http://purl.obolibrary.org/obo/MP_0008290 absent adrenal cortex http://purl.obolibrary.org/obo/MP_0008288 abnormal adrenal cortex morphology absence of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone http://purl.obolibrary.org/obo/MP_0008292 enlarged adrenocortical cell nuclei http://purl.obolibrary.org/obo/MP_0000646 enlarged adrenocortical cells nuclei of the cells of the cortex of the adrenal gland are larger than normal http://purl.obolibrary.org/obo/MP_0008293 abnormal zona glomerulosa morphology http://purl.obolibrary.org/obo/MP_0008288 abnormal adrenal cortex morphology any structural anomaly of the narrow subcapsular outer zone of the adrenal cortex where aldosterone is produced http://purl.obolibrary.org/obo/MP_0008294 abnormal zona fasciculata morphology http://purl.obolibrary.org/obo/MP_0008288 abnormal adrenal cortex morphology any structural anomaly of the wide middle zone of the adrenal cortex that produces cortisol (hydrocortisone) http://purl.obolibrary.org/obo/MP_0008295 abnormal zona reticularis morphology http://purl.obolibrary.org/obo/MP_0008288 abnormal adrenal cortex morphology any structural anomaly of the inner zone of the adrenal cortex that produces the enzymes that convert pregnenolone, a 21-carbon steroid, to 19-carbon steroids http://purl.obolibrary.org/obo/MP_0008296 abnormal x-zone morphology http://purl.obolibrary.org/obo/MP_0008288 abnormal adrenal cortex morphology any structural anomaly of the transient cortical layer juxtaposed to the medulla and the zona reticularis; in males, this zone rapidly involutes at the onset of puberty whereas this zone persists in females until the first pregnancy or later in adulthood in non-pregnant females http://purl.obolibrary.org/obo/MP_0008297 retention of the x-zone http://purl.obolibrary.org/obo/MP_0008296 abnormal x-zone morphology failure of the transient cortical layer juxtaposed to the medulla and the zona reticularis to degenerate after puberty in males or after pregnancy in females http://purl.obolibrary.org/obo/MP_0008298 adrenergic chromaffin cell hyperplasia http://purl.obolibrary.org/obo/MP_0003834 abnormal adrenergic chromaffin cell morphology an increase in the number of the cells of the medulla of the adrenal gland that are innervated by the splanchnic nerve and that are responsible for epinephrine secretion http://purl.obolibrary.org/obo/MP_0008299 adrenal cortical hyperplasia http://purl.obolibrary.org/obo/MP_0008288 abnormal adrenal cortex morphology overdevelopment of the thick outer layer of the adrenal gland that produces and secretes steroid hormones, usually due to an increase in the number of cells http://purl.obolibrary.org/obo/MP_0008300 enlarged adrenal medulla http://purl.obolibrary.org/obo/MP_0008289 abnormal adrenal medulla morphology increased size of the inner portion of the adrenal gland that consists mainly of chromaffin cells http://purl.obolibrary.org/obo/MP_0008301 adrenal medulla hyperplasia http://purl.obolibrary.org/obo/MP_0008300 enlarged adrenal medulla overdevelopment or increased size of the inner portion of the adrenal gland that consists mainly of chromaffin cells, usually due to an increase in the number of cells http://purl.obolibrary.org/obo/MP_0008302 thin adrenal cortex http://purl.obolibrary.org/obo/MP_0008288 abnormal adrenal cortex morphology reduced thickness of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone http://purl.obolibrary.org/obo/MP_0008303 early degeneration of the x-zone http://purl.obolibrary.org/obo/MP_0008296 abnormal x-zone morphology degeneration of the transient cortical layer juxtaposed to the medulla and the zona reticularis prior to the expected time; in males, this zone rapidly involutes at the onset of puberty whereas this zone persists in females until the first pregnancy or later in adulthood in non-pregnant females http://purl.obolibrary.org/obo/MP_0008305 abnormal organ of Corti supporting cell physiology http://purl.obolibrary.org/obo/MP_0003878 abnormal ear physiology any functional anomaly in processes pertinent to the integrated function of the highly differentiated epithelial cells with distinctive morphological features that surround the hair cells in the organ of Corti http://purl.obolibrary.org/obo/MP_0008306 abnormal organ of Corti supporting cell proliferation http://purl.obolibrary.org/obo/MP_0008305 abnormal organ of Corti supporting cell physiology aberrant timing or any anomaly in the ability of supporting cells in the organ of Corti to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0008307 short scala media http://purl.obolibrary.org/obo/MP_0008308 small scala media reduced length of the spirally arranged membranous tube suspended within the cochlea, lying between and separating the scala vestibuli and scala tympani http://purl.obolibrary.org/obo/MP_0008308 small scala media http://purl.obolibrary.org/obo/MP_0003169 abnormal scala media morphology reduced size of the spirally arranged membranous tube suspended within the cochlea, lying between and separating the scala vestibuli and scala tympani http://purl.obolibrary.org/obo/MP_0008309 dilated scala media http://purl.obolibrary.org/obo/MP_0003169 abnormal scala media morphology stretched or widened aperture of the luminal space of the spirally arranged membranous tube suspended within the cochlea, lying between and separating the scala vestibuli and scala tympani http://purl.obolibrary.org/obo/MP_0008310 abnormal sympathetic preganglionic fiber morphology http://purl.obolibrary.org/obo/MP_0001007 abnormal sympathetic system morphology any structural anomaly of any or all of the cholinergic axonal fibers projecting from the CNS to a sympathetic ganglion http://purl.obolibrary.org/obo/MP_0008311 abnormal parasympathetic preganglionic fiber morphology http://purl.obolibrary.org/obo/MP_0001033 abnormal parasympathetic system morphology any structural anomaly of any or all of the cholinergic axonal fibers projecting from the CNS to a parasympathetic ganglion http://purl.obolibrary.org/obo/MP_0008312 abnormal sympathetic postganglionic fiber morphology http://purl.obolibrary.org/obo/MP_0001007 abnormal sympathetic system morphology any structural anomaly of any or all of the noradrenergic and some adrenergic axonal fibers projecting from a sympathetic ganglion to an effector organ http://purl.obolibrary.org/obo/MP_0008313 abnormal parasympathetic postganglionic fiber morphology http://purl.obolibrary.org/obo/MP_0001033 abnormal parasympathetic system morphology any structural anomaly of any or all of the cholinergic axonal fibers projecting from a parasympathetic ganglion to an effector organ http://purl.obolibrary.org/obo/MP_0008314 abnormal pterygopalatine ganglion morphology http://purl.obolibrary.org/obo/MP_0001034 abnormal parasympathetic ganglion morphology any structural anomaly of the small parasympathetic ganglion that supplies nerve fibers to the lacrimal, nasal, palatine and pharyngeal glands http://purl.obolibrary.org/obo/MP_0008315 abnormal otic ganglion morphology http://purl.obolibrary.org/obo/MP_0001034 abnormal parasympathetic ganglion morphology any structural anomaly of the ganglion that supplies nerve fibers to the parotid gland http://purl.obolibrary.org/obo/MP_0008318 abnormal splanchnic nerve morphology http://purl.obolibrary.org/obo/MP_0001007 abnormal sympathetic system morphology any structural anomaly of the major nerves supplying sympathetic innervation to the abdomen, including the greater, lesser, and lowest (or smallest) splanchnic nerves that are formed by preganglionic fibers from the spinal cord which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses and the lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia http://purl.obolibrary.org/obo/MP_0008319 abnormal sympathetic afferent fiber morphology http://purl.obolibrary.org/obo/MP_0001007 abnormal sympathetic system morphology any structural anomaly of the fibers that conduct sensory nerve impulses from the viscera through the posterior dorsal roots into the spinal cord http://purl.obolibrary.org/obo/MP_0008320 absent adenohypophysis http://purl.obolibrary.org/obo/MP_0004163 abnormal adenohypophysis morphology absence of the anterior part of the pituitary that secretes a variety of hormones http://purl.obolibrary.org/obo/MP_0008321 small adenohypophysis http://purl.obolibrary.org/obo/MP_0004163 abnormal adenohypophysis morphology reduced size of the anterior part of the pituitary that secretes a variety of hormones http://purl.obolibrary.org/obo/MP_0008322 abnormal somatotroph morphology http://purl.obolibrary.org/obo/MP_0004163 abnormal adenohypophysis morphology any structural anomaly of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin http://purl.obolibrary.org/obo/MP_0008323 abnormal lactotroph morphology http://purl.obolibrary.org/obo/MP_0004163 abnormal adenohypophysis morphology any structural anomaly of an acidophilic cell of the anterior pituitary that produces prolactin http://purl.obolibrary.org/obo/MP_0008324 abnormal melanotroph morphology http://purl.obolibrary.org/obo/MP_0008130 abnormal pituitary intermediate lobe morphology any structural anomaly of a cell of the intermediate pituitary that produces melanocyte stimulating hormone and other peptides from the post-translational processing of pro-opiomelanocortin (POMC) http://purl.obolibrary.org/obo/MP_0008325 abnormal gonadotroph morphology http://purl.obolibrary.org/obo/MP_0004163 abnormal adenohypophysis morphology any structural anomaly of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH) http://purl.obolibrary.org/obo/MP_0008326 abnormal thyrotroph morphology http://purl.obolibrary.org/obo/MP_0004163 abnormal adenohypophysis morphology any structural anomaly of an anterior pituitary cell that produces thyroid-stimulating hormone http://purl.obolibrary.org/obo/MP_0008327 abnormal corticotroph morphology http://purl.obolibrary.org/obo/MP_0004163 abnormal adenohypophysis morphology any structural anomaly of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH) http://purl.obolibrary.org/obo/MP_0008328 increased somatotroph cell number http://purl.obolibrary.org/obo/MP_0008322 abnormal somatotroph morphology greater number of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin http://purl.obolibrary.org/obo/MP_0008329 decreased somatotroph cell number http://purl.obolibrary.org/obo/MP_0008322 abnormal somatotroph morphology reduced number of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin http://purl.obolibrary.org/obo/MP_0008330 absent somatotrophs http://purl.obolibrary.org/obo/MP_0008329 decreased somatotroph cell number absence of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin http://purl.obolibrary.org/obo/MP_0008331 increased lactotroph cell number http://purl.obolibrary.org/obo/MP_0008323 abnormal lactotroph morphology greater number of an acidophilic cell of the anterior pituitary that produces prolactin http://purl.obolibrary.org/obo/MP_0008332 decreased lactotroph cell number http://purl.obolibrary.org/obo/MP_0008323 abnormal lactotroph morphology reduced number of an acidophilic cell of the anterior pituitary that produces prolactin http://purl.obolibrary.org/obo/MP_0008333 absent lactotrophs http://purl.obolibrary.org/obo/MP_0008332 decreased lactotroph cell number absence of an acidophilic cell of the anterior pituitary that produces prolactin http://purl.obolibrary.org/obo/MP_0008334 increased gonadotroph cell number http://purl.obolibrary.org/obo/MP_0008325 abnormal gonadotroph morphology greater number of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH) http://purl.obolibrary.org/obo/MP_0008335 decreased gonadotroph cell number http://purl.obolibrary.org/obo/MP_0008325 abnormal gonadotroph morphology reduced number of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH) http://purl.obolibrary.org/obo/MP_0008336 absent gonadotrophs http://purl.obolibrary.org/obo/MP_0008335 decreased gonadotroph cell number absence of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH) http://purl.obolibrary.org/obo/MP_0008337 increased thyrotroph cell number http://purl.obolibrary.org/obo/MP_0008326 abnormal thyrotroph morphology greater number of an anterior pituitary cell that produces thyroid-stimulating hormone http://purl.obolibrary.org/obo/MP_0008338 decreased thyrotroph cell number http://purl.obolibrary.org/obo/MP_0008326 abnormal thyrotroph morphology reduced number of an anterior pituitary cell that produces thyroid-stimulating hormone http://purl.obolibrary.org/obo/MP_0008339 absent thyrotrophs http://purl.obolibrary.org/obo/MP_0008338 decreased thyrotroph cell number absence of an anterior pituitary cell that produces thyroid-stimulating hormone http://purl.obolibrary.org/obo/MP_0008340 increased corticotroph cell number http://purl.obolibrary.org/obo/MP_0008327 abnormal corticotroph morphology greater number of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH) http://purl.obolibrary.org/obo/MP_0008341 decreased corticotroph cell number http://purl.obolibrary.org/obo/MP_0008327 abnormal corticotroph morphology reduced number of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH) http://purl.obolibrary.org/obo/MP_0008342 absent corticotrophs http://purl.obolibrary.org/obo/MP_0008341 decreased corticotroph cell number absence of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH) http://purl.obolibrary.org/obo/MP_0008343 abnormal gamma-delta T cell morphology http://purl.obolibrary.org/obo/MP_0008037 abnormal T cell morphology any structural anomaly of an immature or mature T cell expressing an gamma-delta T cell receptor complex http://purl.obolibrary.org/obo/MP_0008344 abnormal mature gamma-delta T cell morphology http://purl.obolibrary.org/obo/MP_0008343 abnormal gamma-delta T cell morphology any structural anomaly of a mature T cell expressing an gamma-delta T cell receptor complex http://purl.obolibrary.org/obo/MP_0008345 abnormal gamma-delta T cell number http://purl.obolibrary.org/obo/MP_0008343 abnormal gamma-delta T cell morphology anomaly in the number of immature or mature T cells expressing an gamma-delta T cell receptor complex http://purl.obolibrary.org/obo/MP_0008346 increased gamma-delta T cell number http://purl.obolibrary.org/obo/MP_0008345 abnormal gamma-delta T cell number greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex http://purl.obolibrary.org/obo/MP_0008347 decreased gamma-delta T cell number http://purl.obolibrary.org/obo/MP_0008345 abnormal gamma-delta T cell number reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex http://purl.obolibrary.org/obo/MP_0008348 absent gamma-delta T cells http://purl.obolibrary.org/obo/MP_0008347 decreased gamma-delta T cell number absence of immature or mature T cells expressing an gamma-delta T cell receptor complex http://purl.obolibrary.org/obo/MP_0008349 abnormal gamma-delta intraepithelial T cell morphology http://purl.obolibrary.org/obo/MP_0008894 abnormal intraepithelial T cell morphology any structural anomaly of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements http://purl.obolibrary.org/obo/MP_0008350 increased gamma-delta intraepithelial T cell number http://purl.obolibrary.org/obo/MP_0008895 abnormal intraepithelial T cell number greater number of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements http://purl.obolibrary.org/obo/MP_0008351 decreased gamma-delta intraepithelial T cell number http://purl.obolibrary.org/obo/MP_0008895 abnormal intraepithelial T cell number reduced number of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements http://purl.obolibrary.org/obo/MP_0008352 absent gamma-delta intraepithelial T cell http://purl.obolibrary.org/obo/MP_0008355 absent mature gamma-delta T cells absence of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements http://purl.obolibrary.org/obo/MP_0008353 increased mature gamma-delta T cell number http://purl.obolibrary.org/obo/MP_0008346 increased gamma-delta T cell number increased number of a mature T cell expressing an gamma-delta T cell receptor complex http://purl.obolibrary.org/obo/MP_0008354 decreased mature gamma-delta T cell number http://purl.obolibrary.org/obo/MP_0008347 decreased gamma-delta T cell number reduced number of a mature T cell expressing an gamma-delta T cell receptor complex http://purl.obolibrary.org/obo/MP_0008355 absent mature gamma-delta T cells http://purl.obolibrary.org/obo/MP_0008354 decreased mature gamma-delta T cell number absence of a mature T cell expressing an gamma-delta T cell receptor complex http://purl.obolibrary.org/obo/MP_0008356 abnormal gamma-delta T cell differentiation http://purl.obolibrary.org/obo/MP_0008343 abnormal gamma-delta T cell morphology atypical production of or inability to produce gamma-delta T cells, and/or accumulation of gamma-delta T cell precursors http://purl.obolibrary.org/obo/MP_0008357 abnormal CD4-positive, gamma-delta intraepithelial T cell morphology http://purl.obolibrary.org/obo/MP_0008349 abnormal gamma-delta intraepithelial T cell morphology any structural anomaly of a CD4-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements http://purl.obolibrary.org/obo/MP_0008358 increased CD4-positive, gamma-delta intraepithelial T cell number http://purl.obolibrary.org/obo/MP_0008357 abnormal CD4-positive, gamma-delta intraepithelial T cell morphology greater number of a CD4-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements http://purl.obolibrary.org/obo/MP_0008359 decreased CD4-positive, gamma-delta intraepithelial T cell number http://purl.obolibrary.org/obo/MP_0008357 abnormal CD4-positive, gamma-delta intraepithelial T cell morphology reduced number of a CD4-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements http://purl.obolibrary.org/obo/MP_0008360 absent CD4-positive, gamma-delta intraepithelial T cells http://purl.obolibrary.org/obo/MP_0008359 decreased CD4-positive, gamma-delta intraepithelial T cell number absence of a CD4-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements http://purl.obolibrary.org/obo/MP_0008361 abnormal CD8-positive, gamma-delta intraepithelial T cell morphology http://purl.obolibrary.org/obo/MP_0008349 abnormal gamma-delta intraepithelial T cell morphology any structural anomaly of a CD8-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements http://purl.obolibrary.org/obo/MP_0008362 increased CD8-positive, gamma-delta intraepithelial T cell number http://purl.obolibrary.org/obo/MP_0008361 abnormal CD8-positive, gamma-delta intraepithelial T cell morphology greater number of a CD8-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements http://purl.obolibrary.org/obo/MP_0008363 decreased CD8-positive, gamma-delta intraepithelial T cell number http://purl.obolibrary.org/obo/MP_0008361 abnormal CD8-positive, gamma-delta intraepithelial T cell morphology reduced number of a CD8-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements http://purl.obolibrary.org/obo/MP_0008364 absent CD8-positive, gamma-delta intraepithelial T cells http://purl.obolibrary.org/obo/MP_0008363 decreased CD8-positive, gamma-delta intraepithelial T cell number absence of a CD8-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements http://purl.obolibrary.org/obo/MP_0008365 adenohypophysis hypoplasia http://purl.obolibrary.org/obo/MP_0008321 small adenohypophysis underdevelopment or reduced size, usually due to a reduced cell number, of the anterior lobe of the pituitary gland http://purl.obolibrary.org/obo/MP_0008366 enlarged adenohypophysis http://purl.obolibrary.org/obo/MP_0004163 abnormal adenohypophysis morphology increased size of the anterior part of the pituitary that secretes a variety of hormones http://purl.obolibrary.org/obo/MP_0008367 absent pituitary intermediate lobe http://purl.obolibrary.org/obo/MP_0008130 abnormal pituitary intermediate lobe morphology absence of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults http://purl.obolibrary.org/obo/MP_0008368 small pituitary intermediate lobe http://purl.obolibrary.org/obo/MP_0008130 abnormal pituitary intermediate lobe morphology reduced size of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults http://purl.obolibrary.org/obo/MP_0008369 pituitary intermediate lobe hypoplasia http://purl.obolibrary.org/obo/MP_0008368 small pituitary intermediate lobe underdevelopment or reduced size, usually due to a reduced cell number, of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults http://purl.obolibrary.org/obo/MP_0008370 enlarged pituitary intermediate lobe http://purl.obolibrary.org/obo/MP_0008130 abnormal pituitary intermediate lobe morphology increased size of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults http://purl.obolibrary.org/obo/MP_0008371 pituitary intermediate lobe hyperplasia http://purl.obolibrary.org/obo/MP_0008370 enlarged pituitary intermediate lobe overdevelopment or increased size, usually due to increased cell number, of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults http://purl.obolibrary.org/obo/MP_0008372 small malleus http://purl.obolibrary.org/obo/MP_0000029 abnormal malleus morphology reduced size of the largest of the three auditory ossicles, which resembles a club or hammer http://purl.obolibrary.org/obo/MP_0008373 short malleus http://purl.obolibrary.org/obo/MP_0008372 small malleus reduced length of the largest of the three auditory ossicles, which resembles a club or hammer http://purl.obolibrary.org/obo/MP_0008374 abnormal malleus manubrium morphology http://purl.obolibrary.org/obo/MP_0000029 abnormal malleus morphology any structural anomaly in the handle of the malleus, which extends downward, inward, and backward from the neck of the malleus and is embedded throughout its length in the tympanic membrane http://purl.obolibrary.org/obo/MP_0008375 short malleus manubrium http://purl.obolibrary.org/obo/MP_0008376 small malleus manubrium reduced length of the handle of the malleus http://purl.obolibrary.org/obo/MP_0008376 small malleus manubrium http://purl.obolibrary.org/obo/MP_0008374 abnormal malleus manubrium morphology reduced size of the handle of the malleus http://purl.obolibrary.org/obo/MP_0008377 absent malleus manubrium http://purl.obolibrary.org/obo/MP_0008374 abnormal malleus manubrium morphology absence of the handle of the malleus http://purl.obolibrary.org/obo/MP_0008378 small malleus processus brevis http://purl.obolibrary.org/obo/MP_0010324 abnormal malleus processus brevis morphology reduced size of the projection extending from the base of the manubrium of the malleus which contacts the upper part of the tympanic membrane http://purl.obolibrary.org/obo/MP_0008379 absent malleus head http://purl.obolibrary.org/obo/MP_0010325 abnormal malleus head morphology absence of the rounded portion of the malleus articulating with the body of the incus http://purl.obolibrary.org/obo/MP_0008380 abnormal gonial bone morphology http://purl.obolibrary.org/obo/MP_0005105 abnormal middle ear ossicle morphology any structural anomaly of the investing bone that lies on the surface of the malleus http://purl.obolibrary.org/obo/MP_0008381 absent gonial bone http://purl.obolibrary.org/obo/MP_0008380 abnormal gonial bone morphology absence of the investing bone that normally lies on the surface of the malleus http://purl.obolibrary.org/obo/MP_0008382 gonial bone hypoplasia http://purl.obolibrary.org/obo/MP_0008380 abnormal gonial bone morphology underdevelopment or reduced size of the investing bone that lies on the surface of the malleus, usually due to reduced cell number http://purl.obolibrary.org/obo/MP_0008383 enlarged gonial bone http://purl.obolibrary.org/obo/MP_0008380 abnormal gonial bone morphology increased size of the investing bone that lies on the surface of the malleus http://purl.obolibrary.org/obo/MP_0008384 absent nasal capsule http://purl.obolibrary.org/obo/MP_0004726 abnormal nasal capsule morphology absence of the cartilage around the developing nasal cavity of the embryo http://purl.obolibrary.org/obo/MP_0008385 absent basisphenoid bone http://purl.obolibrary.org/obo/MP_0000106 abnormal basisphenoid bone morphology absence of the part of the base of the cranium found between the basioccipital and the presphenoid bone http://purl.obolibrary.org/obo/MP_0008386 absent styloid process http://purl.obolibrary.org/obo/MP_0008023 abnormal styloid process morphology absence of the slender needle-like pointed projection that runs downward and slightly forward from the base of the inferior surface of the petrous portion of the temporal bone to join the tympanic portion http://purl.obolibrary.org/obo/MP_0008387 hypochromic anemia http://purl.obolibrary.org/obo/MP_0001577 anemia hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, resulting in insufficient oxygenation of tissues and organs http://purl.obolibrary.org/obo/MP_0008388 hypochromic microcytic anemia http://purl.obolibrary.org/obo/MP_0008387 hypochromic anemia hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is smaller than normal http://purl.obolibrary.org/obo/MP_0008389 hypochromic macrocytic anemia http://purl.obolibrary.org/obo/MP_0008387 hypochromic anemia hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is larger than normal http://purl.obolibrary.org/obo/MP_0008390 abnormal primordial germ cell proliferation http://purl.obolibrary.org/obo/MP_0001919 abnormal reproductive system physiology anomaly in the ability of the primordial germ cell population to undergo rapid expansion by cell division http://purl.obolibrary.org/obo/MP_0008391 abnormal primordial germ cell morphology http://purl.obolibrary.org/obo/MP_0002208 abnormal germ cell morphology any structural anomaly of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge http://purl.obolibrary.org/obo/MP_0008392 decreased primordial germ cell number http://purl.obolibrary.org/obo/MP_0008391 abnormal primordial germ cell morphology reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge http://purl.obolibrary.org/obo/MP_0008393 absent primordial germ cells http://purl.obolibrary.org/obo/MP_0008392 decreased primordial germ cell number absence of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge http://purl.obolibrary.org/obo/MP_0008394 increased primordial germ cell number http://purl.obolibrary.org/obo/MP_0008391 abnormal primordial germ cell morphology greater number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge http://purl.obolibrary.org/obo/MP_0008395 abnormal osteoblast differentiation http://purl.obolibrary.org/obo/MP_0004986 abnormal osteoblast morphology atypical production of or inability to produce skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell http://purl.obolibrary.org/obo/MP_0008396 abnormal osteoclast differentiation http://purl.obolibrary.org/obo/MP_0004982 abnormal osteoclast morphology atypical production of or inability to produce the specialized phagocytic cells associated with the absorption and removal of the mineralized matrix of bone tissue http://purl.obolibrary.org/obo/MP_0008397 abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology http://purl.obolibrary.org/obo/MP_0004941 abnormal regulatory T cell morphology any structural anomaly of a CD4-positive, CD25-positive, alpha-beta T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release http://purl.obolibrary.org/obo/MP_0008398 abnormal CD8-positive, alpha-beta regulatory T cell morphology http://purl.obolibrary.org/obo/MP_0004941 abnormal regulatory T cell morphology any structural anomaly of a CD8-positive, alpha-beta T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release http://purl.obolibrary.org/obo/MP_0008399 abnormal alpha-beta intraepithelial T cell morphology http://purl.obolibrary.org/obo/MP_0008894 abnormal intraepithelial T cell morphology any structural anomaly of a alpha-beta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements http://purl.obolibrary.org/obo/MP_0008400 abnormal CD4-positive, alpha-beta intraepithelial T cell morphology http://purl.obolibrary.org/obo/MP_0008399 abnormal alpha-beta intraepithelial T cell morphology any structural anomaly of a CD4-positive, alpha-beta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements http://purl.obolibrary.org/obo/MP_0008401 abnormal CD8 positive, alpha-beta intraepithelial T cell morphology http://purl.obolibrary.org/obo/MP_0008399 abnormal alpha-beta intraepithelial T cell morphology any structural anomaly of a CD8-positive, alpha-beta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements http://purl.obolibrary.org/obo/MP_0008402 increased cellular sensitivity to alkylating agents http://purl.obolibrary.org/obo/MP_0008943 increased sensitivity to induced cell death greater incidence of cell death following exposure to agents that cause DNA damage http://purl.obolibrary.org/obo/MP_0008403 decreased cellular sensitivity to alkylating agents http://purl.obolibrary.org/obo/MP_0008944 decreased sensitivity to induced cell death reduced incidence of cell death following exposure to agents that cause DNA damage http://purl.obolibrary.org/obo/MP_0008404 increased cellular sensitivity to methylmethanesulfonate http://purl.obolibrary.org/obo/MP_0008402 increased cellular sensitivity to alkylating agents greater incidence of cell death following exposure to methylmethanesulfonate http://purl.obolibrary.org/obo/MP_0008405 decreased cellular sensitivity to methylmethanesulfonate http://purl.obolibrary.org/obo/MP_0008403 decreased cellular sensitivity to alkylating agents reduced incidence of cell death following exposure to methylmethanesulfonate http://purl.obolibrary.org/obo/MP_0008406 increased cellular sensitivity to hydrogen peroxide http://purl.obolibrary.org/obo/MP_0008412 increased cellular sensitivity to oxidative stress greater incidence of cell death following exposure to hydrogen peroxide http://purl.obolibrary.org/obo/MP_0008407 decreased cellular sensitivity to hydrogen peroxide http://purl.obolibrary.org/obo/MP_0008413 decreased cellular sensitivity to oxidative stress reduced incidence of cell death following exposure to hydrogen peroxide http://purl.obolibrary.org/obo/MP_0008408 decreased cellular sensitivity to hydroxyurea http://purl.obolibrary.org/obo/MP_0008403 decreased cellular sensitivity to alkylating agents reduced incidence of cell death following exposure to hydroxyurea http://purl.obolibrary.org/obo/MP_0008409 increased cellular sensitivity to hydroxyurea http://purl.obolibrary.org/obo/MP_0008402 increased cellular sensitivity to alkylating agents greater incidence of cell death following exposure to hydroxyurea http://purl.obolibrary.org/obo/MP_0008410 increased cellular sensitivity to ultraviolet irradiation http://purl.obolibrary.org/obo/MP_0008943 increased sensitivity to induced cell death greater incidence of cell death following exposure to ultraviolet irradiation http://purl.obolibrary.org/obo/MP_0008411 decreased cellular sensitivity to ultraviolet irradiation http://purl.obolibrary.org/obo/MP_0008944 decreased sensitivity to induced cell death reduced incidence of cell death following exposure to ultraviolet irradiation http://purl.obolibrary.org/obo/MP_0008412 increased cellular sensitivity to oxidative stress http://purl.obolibrary.org/obo/MP_0008943 increased sensitivity to induced cell death greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis http://purl.obolibrary.org/obo/MP_0008413 decreased cellular sensitivity to oxidative stress http://purl.obolibrary.org/obo/MP_0008944 decreased sensitivity to induced cell death reduced incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis http://purl.obolibrary.org/obo/MP_0008414 abnormal spatial reference memory http://purl.obolibrary.org/obo/MP_0002063 abnormal learning/memory/conditioning anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to navigate or perform other behavior using such location cues http://purl.obolibrary.org/obo/MP_0008415 abnormal neurite morphology http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture http://purl.obolibrary.org/obo/MP_0008416 increased somatotroph cell size http://purl.obolibrary.org/obo/MP_0008322 abnormal somatotroph morphology excessive growth or enlargement of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin http://purl.obolibrary.org/obo/MP_0008417 decreased somatotroph cell size http://purl.obolibrary.org/obo/MP_0008322 abnormal somatotroph morphology reduced growth or small size of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin http://purl.obolibrary.org/obo/MP_0008418 abnormal cutaneous elastic fiber morphology http://purl.obolibrary.org/obo/MP_0002060 abnormal skin morphology any structural anomaly of the slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity http://purl.obolibrary.org/obo/MP_0008419 abnormal cutaneous microfibril morphology http://purl.obolibrary.org/obo/MP_0008418 abnormal cutaneous elastic fiber morphology any structural anomaly of the fiber-like strand of fibrillin that forms the scaffold of the cutaneous elastic fibers found in the extracellular matrix of the skin http://purl.obolibrary.org/obo/MP_0008420 increased thyrotroph cell size http://purl.obolibrary.org/obo/MP_0008326 abnormal thyrotroph morphology excessive growth or enlargement of an anterior pituitary cell that produces thyroid-stimulating hormone http://purl.obolibrary.org/obo/MP_0008421 decreased thyrotroph cell size http://purl.obolibrary.org/obo/MP_0008326 abnormal thyrotroph morphology reduced growth or small size of an anterior pituitary cell that produces thyroid-stimulating hormone http://purl.obolibrary.org/obo/MP_0008422 increased lactotroph cell size http://purl.obolibrary.org/obo/MP_0008323 abnormal lactotroph morphology excessive growth or enlargement of an acidophilic cell of the anterior pituitary that produces prolactin http://purl.obolibrary.org/obo/MP_0008423 decreased lactotroph cell size http://purl.obolibrary.org/obo/MP_0008323 abnormal lactotroph morphology reduced growth or small size of an acidophilic cell of the anterior pituitary that produces prolactin http://purl.obolibrary.org/obo/MP_0008424 increased gonadotroph cell size http://purl.obolibrary.org/obo/MP_0008325 abnormal gonadotroph morphology excessive growth or enlargement of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH) http://purl.obolibrary.org/obo/MP_0008425 decreased gonadotroph cell size http://purl.obolibrary.org/obo/MP_0008325 abnormal gonadotroph morphology reduced growth or small size of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH) http://purl.obolibrary.org/obo/MP_0008426 increased corticotroph cell size http://purl.obolibrary.org/obo/MP_0008327 abnormal corticotroph morphology excessive growth or enlargement of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH) http://purl.obolibrary.org/obo/MP_0008427 decreased corticotroph cell size http://purl.obolibrary.org/obo/MP_0008327 abnormal corticotroph morphology reduced growth or small size of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH) http://purl.obolibrary.org/obo/MP_0008428 abnormal spatial working memory http://purl.obolibrary.org/obo/MP_0002063 abnormal learning/memory/conditioning anomaly in the ability to spontaneously process spatial location information in order to navigate or perform other behavior using such location cues, without previous encounters or training at that location http://purl.obolibrary.org/obo/MP_0008429 absent parotid gland http://purl.obolibrary.org/obo/MP_0003452 abnormal parotid gland morphology absence of the largest of the major salivary glands situated below and in front of each ear http://purl.obolibrary.org/obo/MP_0008430 short squamosal bone http://purl.obolibrary.org/obo/MP_0004423 abnormal squamosal bone morphology length reduction of the thin, platelike part of the temporal bone http://purl.obolibrary.org/obo/MP_0008431 abnormal short term spatial reference memory http://purl.obolibrary.org/obo/MP_0008414 abnormal spatial reference memory anomaly in the short-term memory for spatial location information that is established during the first few minutes after training or an encounter at that location http://purl.obolibrary.org/obo/MP_0008432 abnormal long term spatial reference memory http://purl.obolibrary.org/obo/MP_0008414 abnormal spatial reference memory anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location http://purl.obolibrary.org/obo/MP_0008433 abnormal somatotroph cell nucleus http://purl.obolibrary.org/obo/MP_0008322 abnormal somatotroph morphology any structural anomaly of a somatotroph cell nucleus http://purl.obolibrary.org/obo/MP_0008434 small somatotroph cell nucleus http://purl.obolibrary.org/obo/MP_0008433 abnormal somatotroph cell nucleus decreased size of a somatotroph cell nucleus http://purl.obolibrary.org/obo/MP_0008435 large somatotroph cell nucleus http://purl.obolibrary.org/obo/MP_0008433 abnormal somatotroph cell nucleus increased size of a somatotroph cell nucleus http://purl.obolibrary.org/obo/MP_0008436 decreased somatotroph secretory granule number http://purl.obolibrary.org/obo/MP_0008322 abnormal somatotroph morphology decreased number of vesicles derived from the golgi that contain somatotropin growth hormone to be released at the cell surface http://purl.obolibrary.org/obo/MP_0008437 absent somatotroph secretory granules http://purl.obolibrary.org/obo/MP_0008436 decreased somatotroph secretory granule number absence of vesicles derived from the golgi that contain somatotropin growth hormone to be released at the cell surface http://purl.obolibrary.org/obo/MP_0008438 abnormal cutaneous collagen fibril morphology http://purl.obolibrary.org/obo/MP_0002060 abnormal skin morphology any structural anomaly of the connective tissue bundles in the extracellular matrix of skin tissue that are composed of collagen, and play a role in skin strength and elasticity http://purl.obolibrary.org/obo/MP_0008439 abnormal cortical plate morphology http://purl.obolibrary.org/obo/MP_0000934 abnormal telencephalon development any structural anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers http://purl.obolibrary.org/obo/MP_0008440 abnormal subplate morphology http://purl.obolibrary.org/obo/MP_0000934 abnormal telencephalon development any structural anomaly of the transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate http://purl.obolibrary.org/obo/MP_0008441 thin cortical plate http://purl.obolibrary.org/obo/MP_0008439 abnormal cortical plate morphology reduced thickness of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers http://purl.obolibrary.org/obo/MP_0008442 disorganized cortical plate http://purl.obolibrary.org/obo/MP_0008439 abnormal cortical plate morphology derangement of the patterned arrangement of the cortical plate http://purl.obolibrary.org/obo/MP_0008443 absent subplate http://purl.obolibrary.org/obo/MP_0008440 abnormal subplate morphology absence of the transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate http://purl.obolibrary.org/obo/MP_0008444 retinal cone cell degeneration http://purl.obolibrary.org/obo/MP_0008450 retinal photoreceptor degeneration a retrogressive impairment of function or destruction of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment http://purl.obolibrary.org/obo/MP_0008445 increased retinal cone cell number http://purl.obolibrary.org/obo/MP_0006070 increased retinal photoreceptor cell number greater number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment http://purl.obolibrary.org/obo/MP_0008446 decreased retinal cone cell number http://purl.obolibrary.org/obo/MP_0001327 decreased retinal photoreceptor cell number reduced number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment http://purl.obolibrary.org/obo/MP_0008447 absent retinal cone cells http://purl.obolibrary.org/obo/MP_0008446 decreased retinal cone cell number absence of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment http://purl.obolibrary.org/obo/MP_0008448 abnormal retinal cone cell inner segment morphology http://purl.obolibrary.org/obo/MP_0003730 abnormal photoreceptor inner segment morphology any structural anomaly of the retinal cone cell region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region http://purl.obolibrary.org/obo/MP_0008449 abnormal retinal cone cell outer segment morphology http://purl.obolibrary.org/obo/MP_0003729 abnormal photoreceptor outer segment morphology any structural anomaly of the retinal cone cell region in which the visual pigment rhodopsin is in invaginations of the cell membrane http://purl.obolibrary.org/obo/MP_0008450 retinal photoreceptor degeneration http://purl.obolibrary.org/obo/MP_0003224 neuron degeneration a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina http://purl.obolibrary.org/obo/MP_0008451 retinal rod cell degeneration http://purl.obolibrary.org/obo/MP_0008450 retinal photoreceptor degeneration a retrogressive impairment of function or destruction of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane http://purl.obolibrary.org/obo/MP_0008452 increased retinal rod cell number http://purl.obolibrary.org/obo/MP_0006070 increased retinal photoreceptor cell number greater number of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane http://purl.obolibrary.org/obo/MP_0008453 decreased retinal rod cell number http://purl.obolibrary.org/obo/MP_0001327 decreased retinal photoreceptor cell number reduced number of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane http://purl.obolibrary.org/obo/MP_0008454 absent retinal rod cells http://purl.obolibrary.org/obo/MP_0008453 decreased retinal rod cell number absence of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane http://purl.obolibrary.org/obo/MP_0008455 abnormal retinal rod cell inner segment morphology http://purl.obolibrary.org/obo/MP_0003730 abnormal photoreceptor inner segment morphology any structural anomaly of the retinal rod cell region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region http://purl.obolibrary.org/obo/MP_0008456 abnormal retinal rod cell outer segment morphology http://purl.obolibrary.org/obo/MP_0003729 abnormal photoreceptor outer segment morphology any structural anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin http://purl.obolibrary.org/obo/MP_0008457 abnormal cortical intermediate zone morphology http://purl.obolibrary.org/obo/MP_0000934 abnormal telencephalon development any structural anomaly of the region of the developing mammalian cortex that extends between the ventricular zone and the cortical plate (CP); normally, the IZ is a region of tangential migration of cells, and at midgestation, the lower part of the IZ develops into the subventricular zone http://purl.obolibrary.org/obo/MP_0008458 abnormal cortical ventricular zone morphology http://purl.obolibrary.org/obo/MP_0000934 abnormal telencephalon development any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons http://purl.obolibrary.org/obo/MP_0008459 abnormal circulating pancreatic peptide level http://purl.obolibrary.org/obo/MP_0005418 abnormal circulating hormone level anomaly in the amount of the 36-amino acid pancreatic hormone in the blood that is secreted mainly by endocrine cells found at the periphery of the islets of Langerhans in response to ingestions, and regulates gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite http://purl.obolibrary.org/obo/MP_0008460 absent dorsal root ganglion http://purl.obolibrary.org/obo/MP_0000961 abnormal dorsal root ganglion morphology absence of the groups of sensory nerve cell bodies located on the dorsal spinal roots within the vertebral column http://purl.obolibrary.org/obo/MP_0008461 left atrial isomerism http://purl.obolibrary.org/obo/MP_0006065 abnormal heart position or orientation anomaly in the asymmetry of the cardiac atria such that atria on both the left and right side have the morphology normally seen on the left side of the body http://purl.obolibrary.org/obo/MP_0008462 abnormal medium spiny neuron morphology http://purl.obolibrary.org/obo/MP_0004077 abnormal striatum morphology any structural anomaly of the inhibitory projection neurons located in the striatum that integrate glutamatergic signals arising from the cerebral cortex and thalamus http://purl.obolibrary.org/obo/MP_0008464 absent peripheral lymph nodes http://purl.obolibrary.org/obo/MP_0008463 abnormal peripheral lymph node morphology absence of the lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes http://purl.obolibrary.org/obo/MP_0008465 absent mesenteric lymph nodes http://purl.obolibrary.org/obo/MP_0005232 abnormal mesenteric lymph node morphology absence of the lymph nodes located in the mesentery, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group http://purl.obolibrary.org/obo/MP_0008466 enlarged mesenteric lymph nodes http://purl.obolibrary.org/obo/MP_0005232 abnormal mesenteric lymph node morphology increased size of the lymph nodes located in the mesentery, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group http://purl.obolibrary.org/obo/MP_0008467 absent proprioceptive neurons http://purl.obolibrary.org/obo/MP_0004297 abnormal proprioceptive neuron morphology absence of the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord http://purl.obolibrary.org/obo/MP_0008468 absent muscle spindles http://purl.obolibrary.org/obo/MP_0008486 decreased muscle spindle number absence of the sensory organs in muscle that are involved in the stretch reflex http://purl.obolibrary.org/obo/MP_0008469 abnormal protein level http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis anomaly in the amount of any of the macromolecules consisting of long chains of amino acids in peptide linkage http://purl.obolibrary.org/obo/MP_0008470 abnormal spleen B cell follicle morphology http://purl.obolibrary.org/obo/MP_0002357 abnormal spleen white pulp morphology any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur http://purl.obolibrary.org/obo/MP_0008471 abnormal spleen primary B follicle morphology http://purl.obolibrary.org/obo/MP_0008470 abnormal spleen B cell follicle morphology any structural anomaly of the nodules of small undifferentiated B lymphocytes and follicular dendritic cells located in the spleen white pulp http://purl.obolibrary.org/obo/MP_0008473 abnormal spleen follicular dendritic cell network http://purl.obolibrary.org/obo/MP_0008470 abnormal spleen B cell follicle morphology any structural anomaly of the enmeshed group of antigen presenting cells with extensive dendritic processes in the spleen B cell follicle that present antigen to B cells during an immune response http://purl.obolibrary.org/obo/MP_0008474 absent spleen germinal center http://purl.obolibrary.org/obo/MP_0002359 abnormal spleen germinal center morphology absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs http://purl.obolibrary.org/obo/MP_0008475 intermingled spleen red and white pulp http://purl.obolibrary.org/obo/MP_0002357 abnormal spleen white pulp morphology no clear demarcation of the spleen red and white pulp tissue http://purl.obolibrary.org/obo/MP_0008476 increased spleen red pulp amount http://purl.obolibrary.org/obo/MP_0002356 abnormal spleen red pulp morphology increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation http://purl.obolibrary.org/obo/MP_0008477 decreased spleen red pulp amount http://purl.obolibrary.org/obo/MP_0002356 abnormal spleen red pulp morphology reduction in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation http://purl.obolibrary.org/obo/MP_0008478 increased spleen white pulp amount http://purl.obolibrary.org/obo/MP_0002357 abnormal spleen white pulp morphology increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies http://purl.obolibrary.org/obo/MP_0008479 decreased spleen white pulp amount http://purl.obolibrary.org/obo/MP_0002357 abnormal spleen white pulp morphology reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies http://purl.obolibrary.org/obo/MP_0008480 absent eye pigmentation http://purl.obolibrary.org/obo/MP_0001324 abnormal eye pigmentation absence of melanin (pigment) in the eye either due to absent melanocytes or failure of melanin synthesis http://purl.obolibrary.org/obo/MP_0008481 increased spleen germinal center number http://purl.obolibrary.org/obo/MP_0002359 abnormal spleen germinal center morphology greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs http://purl.obolibrary.org/obo/MP_0008482 decreased spleen germinal center number http://purl.obolibrary.org/obo/MP_0002359 abnormal spleen germinal center morphology reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs http://purl.obolibrary.org/obo/MP_0008483 increased spleen germinal center size http://purl.obolibrary.org/obo/MP_0002359 abnormal spleen germinal center morphology greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs http://purl.obolibrary.org/obo/MP_0008484 decreased spleen germinal center size http://purl.obolibrary.org/obo/MP_0002359 abnormal spleen germinal center morphology reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs http://purl.obolibrary.org/obo/MP_0008485 increased muscle spindle number http://purl.obolibrary.org/obo/MP_0004069 abnormal muscle spindle morphology greater number of the sensory organs in muscle that are involved in the stretch reflex http://purl.obolibrary.org/obo/MP_0008486 decreased muscle spindle number http://purl.obolibrary.org/obo/MP_0004069 abnormal muscle spindle morphology reduced number of the sensory organs in muscle that are involved in the stretch reflex http://purl.obolibrary.org/obo/MP_0008489 slow postnatal weight gain http://purl.obolibrary.org/obo/MP_0001732 postnatal growth retardation the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults http://purl.obolibrary.org/obo/MP_0008490 enlarged dorsal root ganglion http://purl.obolibrary.org/obo/MP_0000961 abnormal dorsal root ganglion morphology increased size a group of sensory nerve cell bodies located on the dorsal spinal roots within the vertebral column http://purl.obolibrary.org/obo/MP_0008491 dorsal root ganglion hyperplasia http://purl.obolibrary.org/obo/MP_0008490 enlarged dorsal root ganglion overdevelopment or increased size, usually due to a increased cell number, of a dorsal root ganglion or ganglia http://purl.obolibrary.org/obo/MP_0008492 dorsal root ganglion degeneration http://purl.obolibrary.org/obo/MP_0000961 abnormal dorsal root ganglion morphology retrogressive pathological change of a group of sensory nerve cell bodies located on the dorsal spinal roots within the vertebral column http://purl.obolibrary.org/obo/MP_0008493 alpha-synuclein inclusion body http://purl.obolibrary.org/obo/MP_0003632 abnormal nervous system morphology formation of aggregates of the alpha-synuclein protein in neural and glial tissue; often seen in neurodegenerative disorders such as Parkinson's disease http://purl.obolibrary.org/obo/MP_0008494 absence of all nails http://purl.obolibrary.org/obo/MP_0000579 abnormal nail morphology absence of all of the horny plates covering the dorsal surface of the distal end of each terminal phalanx of the digits http://purl.obolibrary.org/obo/MP_0008495 decreased IgG1 level http://purl.obolibrary.org/obo/MP_0020175 abnormal IgG1 level less than normal immunoglobulin class G1 level http://purl.obolibrary.org/obo/MP_0008496 decreased IgG2a level http://purl.obolibrary.org/obo/MP_0020176 abnormal IgG2a level less than normal immunoglobulin class G2a level http://purl.obolibrary.org/obo/MP_0008497 decreased IgG2b level http://purl.obolibrary.org/obo/MP_0020177 abnormal IgG2b level less than normal immunoglobulin class G2b level http://purl.obolibrary.org/obo/MP_0008498 decreased IgG3 level http://purl.obolibrary.org/obo/MP_0020179 abnormal IgG3 level less than normal immunoglobulin class G3 level http://purl.obolibrary.org/obo/MP_0008499 increased IgG1 level http://purl.obolibrary.org/obo/MP_0020175 abnormal IgG1 level greater than normal immunoglobulin class G1 level http://purl.obolibrary.org/obo/MP_0008500 increased IgG2a level http://purl.obolibrary.org/obo/MP_0020176 abnormal IgG2a level greater than normal immunoglobulin class G2a level http://purl.obolibrary.org/obo/MP_0008501 increased IgG2b level http://purl.obolibrary.org/obo/MP_0020177 abnormal IgG2b level greater than normal immunoglobulin class G2b level http://purl.obolibrary.org/obo/MP_0008502 increased IgG3 level http://purl.obolibrary.org/obo/MP_0020179 abnormal IgG3 level greater than normal immunoglobulin class G3 level http://purl.obolibrary.org/obo/MP_0008505 absent adrenal chromaffin cells http://purl.obolibrary.org/obo/MP_0008504 abnormal adrenal chromaffin cell morphology absence of the neuroendocrine cells of the medulla of the adrenal gland that are innervated by the splanchnic nerve and that are responsible for epinephrine and norepinephrine secretion http://purl.obolibrary.org/obo/MP_0008506 abnormal noradrenergic chromaffin cell morphology http://purl.obolibrary.org/obo/MP_0008504 abnormal adrenal chromaffin cell morphology any structural anomaly of the neuroendocrine cells of the medulla of the adrenal gland that are innervated by the splanchnic nerve and that are responsible for norepinephrine secretion http://purl.obolibrary.org/obo/MP_0008507 thin retinal ganglion layer http://purl.obolibrary.org/obo/MP_0005241 abnormal retinal ganglion layer morphology reduced thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain http://purl.obolibrary.org/obo/MP_0008508 thick retinal ganglion layer http://purl.obolibrary.org/obo/MP_0005241 abnormal retinal ganglion layer morphology increased thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain http://purl.obolibrary.org/obo/MP_0008509 disorganized retinal ganglion layer http://purl.obolibrary.org/obo/MP_0005241 abnormal retinal ganglion layer morphology derangement of the pattern of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain http://purl.obolibrary.org/obo/MP_0008510 absent retinal ganglion layer http://purl.obolibrary.org/obo/MP_0005241 abnormal retinal ganglion layer morphology absence of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain http://purl.obolibrary.org/obo/MP_0008511 thin retinal inner nuclear layer http://purl.obolibrary.org/obo/MP_0011996 abnormal retinal inner nuclear layer thickness reduced thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells http://purl.obolibrary.org/obo/MP_0008512 disorganized retinal inner nuclear layer http://purl.obolibrary.org/obo/MP_0003733 abnormal retinal inner nuclear layer morphology derangement of the normal pattern of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells http://purl.obolibrary.org/obo/MP_0008513 thin retinal inner plexiform layer http://purl.obolibrary.org/obo/MP_0003734 abnormal retinal inner plexiform layer morphology reduced thickness of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites http://purl.obolibrary.org/obo/MP_0008514 absent retinal inner plexiform layer http://purl.obolibrary.org/obo/MP_0003734 abnormal retinal inner plexiform layer morphology absence of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites http://purl.obolibrary.org/obo/MP_0008515 thin retinal outer nuclear layer http://purl.obolibrary.org/obo/MP_0011997 abnormal retinal outer nuclear layer thickness reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones http://purl.obolibrary.org/obo/MP_0008516 disorganized retinal outer nuclear layer http://purl.obolibrary.org/obo/MP_0003731 abnormal retinal outer nuclear layer morphology derangement of the normal pattern of the retinal layer that contains the nuclei and cell bodies of rods and cones http://purl.obolibrary.org/obo/MP_0008517 thick retinal outer nuclear layer http://purl.obolibrary.org/obo/MP_0011997 abnormal retinal outer nuclear layer thickness increased thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones http://purl.obolibrary.org/obo/MP_0008518 retinal outer nuclear layer degeneration http://purl.obolibrary.org/obo/MP_0003731 abnormal retinal outer nuclear layer morphology a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones http://purl.obolibrary.org/obo/MP_0008519 thin retinal outer plexiform layer http://purl.obolibrary.org/obo/MP_0003732 abnormal retinal outer plexiform layer morphology reduced thickness of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites) http://purl.obolibrary.org/obo/MP_0008520 disorganized retinal outer plexiform layer http://purl.obolibrary.org/obo/MP_0003732 abnormal retinal outer plexiform layer morphology a derangement of the normal pattern of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites) http://purl.obolibrary.org/obo/MP_0008521 abnormal Bowman membrane http://purl.obolibrary.org/obo/MP_0001312 abnormal cornea morphology any structural anomaly of the layer of acellular matrix that lies beneath the corneal epithelium and above the corneal stroma, consists of randomly arranged collagen fibers in a condensed bed of intercellular substance, and provides stability and strength to the cornea http://purl.obolibrary.org/obo/MP_0008522 abnormal lymph node germinal center morphology http://purl.obolibrary.org/obo/MP_0002346 abnormal lymph node secondary follicle morphology any structural anomaly of the area of the lymph node secondary follicle where antigen-activated B-cell blasts are stimulated by antigens and proliferate, with the immunoglobulin genes undergoing somatic hypermutation, before the cells migrate away as plasma cells or memory cells http://purl.obolibrary.org/obo/MP_0008523 absent lymph node germinal center http://purl.obolibrary.org/obo/MP_0008522 abnormal lymph node germinal center morphology absence of the area of the lymph node secondary follicle where antigen-activated B-cell blasts are stimulated by antigens and proliferate, with the immunoglobulin genes undergoing somatic hypermutation, before the cells migrate away as plasma cells or memory cells http://purl.obolibrary.org/obo/MP_0008524 increased plasmacytoid dendritic cell number http://purl.obolibrary.org/obo/MP_0008123 abnormal plasmacytoid dendritic cell number greater number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli http://purl.obolibrary.org/obo/MP_0008525 decreased cranium height http://purl.obolibrary.org/obo/MP_0010031 abnormal cranium size decrease in the rostral-caudal distance between the cranial base and the upper domelike portion of the skull http://purl.obolibrary.org/obo/MP_0008526 decreased cranium width http://purl.obolibrary.org/obo/MP_0010031 abnormal cranium size having a decreased side-to-side, or lateral distance of the cranium http://purl.obolibrary.org/obo/MP_0008527 embryonic lethality at implantation http://purl.obolibrary.org/obo/MP_0013292 embryonic lethality prior to organogenesis death due to failure of implantation (Mus: E4.5) http://purl.obolibrary.org/obo/MP_0008528 polycystic kidney http://purl.obolibrary.org/obo/MP_0003675 kidney cysts the development of innumerable cysts in the kidneys filled with fluid replacing much of the mass of the kidneys leading to reduction in kidney function and frequently kidney failure http://purl.obolibrary.org/obo/MP_0008529 enlarged optic nerve http://purl.obolibrary.org/obo/MP_0001330 abnormal optic nerve morphology increased size of the second cranial nerve which is responsible for conveying visual information from the retina to the brain; it extends from the retina to the optic chiasma where part of its fibers become the optic tract and cross to the opposite side and pass to the geniculate bodies http://purl.obolibrary.org/obo/MP_0008530 abnormal rostral-caudal patterning of the somites http://purl.obolibrary.org/obo/MP_0005221 abnormal rostral-caudal axis patterning anomaly in the developmental pattern of the somites along the axis that runs from the rostral to the caudal region of the body http://purl.obolibrary.org/obo/MP_0008531 increased chemical nociceptive threshold http://purl.obolibrary.org/obo/MP_0003043 hypoalgesia a greater than average concentration at which chemically induced pain sensation is first detectable http://purl.obolibrary.org/obo/MP_0008532 decreased chemical nociceptive threshold http://purl.obolibrary.org/obo/MP_0005407 hyperalgesia a lower than average concentration at which chemically induced pain sensation is first detectable http://purl.obolibrary.org/obo/MP_0008533 abnormal anterior visceral endoderm morphology http://purl.obolibrary.org/obo/MP_0011186 abnormal visceral endoderm morphology any structural anomaly of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue http://purl.obolibrary.org/obo/MP_0008534 enlarged fourth ventricle http://purl.obolibrary.org/obo/MP_0011380 enlarged brain ventricles increased size of the irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space http://purl.obolibrary.org/obo/MP_0008535 enlarged lateral ventricles http://purl.obolibrary.org/obo/MP_0011380 enlarged brain ventricles increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle http://purl.obolibrary.org/obo/MP_0008536 enlarged third ventricle http://purl.obolibrary.org/obo/MP_0011380 enlarged brain ventricles increased size of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina http://purl.obolibrary.org/obo/MP_0008537 increased susceptibility to induced colitis http://purl.obolibrary.org/obo/MP_0013296 abnormal susceptibility to induced colitis increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS) http://purl.obolibrary.org/obo/MP_0008538 decreased zigzag hair amount http://purl.obolibrary.org/obo/MP_0000402 abnormal zigzag hair morphology reduced number of the truncal hairs that have two or more sharp bends with diameter constrictions at the bends, and contain one air cell in the medulla http://purl.obolibrary.org/obo/MP_0008539 decreased susceptibility to induced colitis http://purl.obolibrary.org/obo/MP_0013296 abnormal susceptibility to induced colitis decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS) http://purl.obolibrary.org/obo/MP_0008541 leukostasis http://purl.obolibrary.org/obo/MP_0002442 abnormal leukocyte physiology abnormal intravascular leukocyte aggregation and clumping most commonly seen in the brain and lungs of organisms with leukemia, often with an excess of leukocytes in the blood http://purl.obolibrary.org/obo/MP_0008542 enlarged cervical lymph nodes http://purl.obolibrary.org/obo/MP_0002351 abnormal cervical lymph node morphology increased size of the lymph nodes found near the neck and shoulders http://purl.obolibrary.org/obo/MP_0008543 atrial fibrillation http://purl.obolibrary.org/obo/MP_0006109 fibrillation asynchronous contraction or quivering of individual cardiac muscle fibers in the atria http://purl.obolibrary.org/obo/MP_0008544 impaired olfaction http://purl.obolibrary.org/obo/MP_0001984 abnormal olfaction reduced ability to detect odors http://purl.obolibrary.org/obo/MP_0008545 absent sperm flagellum http://purl.obolibrary.org/obo/MP_0008892 abnormal sperm flagellum morphology absence of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility http://purl.obolibrary.org/obo/MP_0008546 abnormal vesicle-mediated transport http://purl.obolibrary.org/obo/MP_0005621 abnormal cell physiology anomaly in the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell http://purl.obolibrary.org/obo/MP_0008547 abnormal neocortex morphology http://purl.obolibrary.org/obo/MP_0000788 abnormal cerebral cortex morphology any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers http://purl.obolibrary.org/obo/MP_0008548 abnormal circulating interferon level http://purl.obolibrary.org/obo/MP_0010210 abnormal circulating cytokine level anomaly in the amount in the blood of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions http://purl.obolibrary.org/obo/MP_0008549 abnormal circulating interferon-alpha level http://purl.obolibrary.org/obo/MP_0008548 abnormal circulating interferon level anomaly in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells http://purl.obolibrary.org/obo/MP_0008550 abnormal circulating interferon-beta level http://purl.obolibrary.org/obo/MP_0008548 abnormal circulating interferon level anomaly in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity http://purl.obolibrary.org/obo/MP_0008551 abnormal circulating interferon-gamma level http://purl.obolibrary.org/obo/MP_0008548 abnormal circulating interferon level anomaly in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation http://purl.obolibrary.org/obo/MP_0008552 abnormal circulating tumor necrosis factor level http://purl.obolibrary.org/obo/MP_0010210 abnormal circulating cytokine level anomaly in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium http://purl.obolibrary.org/obo/MP_0008553 increased circulating tumor necrosis factor level http://purl.obolibrary.org/obo/MP_0008552 abnormal circulating tumor necrosis factor level greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium http://purl.obolibrary.org/obo/MP_0008554 decreased circulating tumor necrosis factor level http://purl.obolibrary.org/obo/MP_0008552 abnormal circulating tumor necrosis factor level reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium http://purl.obolibrary.org/obo/MP_0008555 abnormal interferon secretion http://purl.obolibrary.org/obo/MP_0003009 abnormal cytokine secretion anomaly in the production or release of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions http://purl.obolibrary.org/obo/MP_0008556 abnormal tumor necrosis factor secretion http://purl.obolibrary.org/obo/MP_0003009 abnormal cytokine secretion anomaly in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium http://purl.obolibrary.org/obo/MP_0008557 abnormal interferon-alpha secretion http://purl.obolibrary.org/obo/MP_0008555 abnormal interferon secretion anomaly in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells http://purl.obolibrary.org/obo/MP_0008558 abnormal interferon-beta secretion http://purl.obolibrary.org/obo/MP_0008555 abnormal interferon secretion anomaly in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity http://purl.obolibrary.org/obo/MP_0008559 abnormal interferon-gamma secretion http://purl.obolibrary.org/obo/MP_0008555 abnormal interferon secretion anomaly in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation http://purl.obolibrary.org/obo/MP_0008560 increased tumor necrosis factor secretion http://purl.obolibrary.org/obo/MP_0008556 abnormal tumor necrosis factor secretion increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium http://purl.obolibrary.org/obo/MP_0008561 decreased tumor necrosis factor secretion http://purl.obolibrary.org/obo/MP_0008556 abnormal tumor necrosis factor secretion reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium http://purl.obolibrary.org/obo/MP_0008562 increased interferon-alpha secretion http://purl.obolibrary.org/obo/MP_0008557 abnormal interferon-alpha secretion increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells http://purl.obolibrary.org/obo/MP_0008563 decreased interferon-alpha secretion http://purl.obolibrary.org/obo/MP_0008557 abnormal interferon-alpha secretion decrease in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells http://purl.obolibrary.org/obo/MP_0008564 increased interferon-beta secretion http://purl.obolibrary.org/obo/MP_0008558 abnormal interferon-beta secretion increase in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity http://purl.obolibrary.org/obo/MP_0008565 decreased interferon-beta secretion http://purl.obolibrary.org/obo/MP_0008558 abnormal interferon-beta secretion reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity http://purl.obolibrary.org/obo/MP_0008566 increased interferon-gamma secretion http://purl.obolibrary.org/obo/MP_0008559 abnormal interferon-gamma secretion increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation http://purl.obolibrary.org/obo/MP_0008567 decreased interferon-gamma secretion http://purl.obolibrary.org/obo/MP_0008559 abnormal interferon-gamma secretion reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation http://purl.obolibrary.org/obo/MP_0008568 abnormal interleukin secretion http://purl.obolibrary.org/obo/MP_0003009 abnormal cytokine secretion anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli http://purl.obolibrary.org/obo/MP_0008569 lethality at weaning http://purl.obolibrary.org/obo/MP_0010769 abnormal survival premature death at weaning age, often due to the inability to make the transition to solid food http://purl.obolibrary.org/obo/MP_0008570 lipidosis http://purl.obolibrary.org/obo/MP_0001547 abnormal lipid level abnormal fat metabolism with increased accumulation of specific lipids in tissue http://purl.obolibrary.org/obo/MP_0008571 abnormal synaptic bouton morphology http://purl.obolibrary.org/obo/MP_0005404 abnormal axon morphology any structural anomaly of the knoblike enlargements along the course of axons, or more commonly at the distal terminations of axons which are specialized for the release of neurotransmitters http://purl.obolibrary.org/obo/MP_0008572 abnormal Purkinje cell dendrite morphology http://purl.obolibrary.org/obo/MP_0008143 abnormal dendrite morphology any structural anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer http://purl.obolibrary.org/obo/MP_0008573 increased circulating interferon-alpha level http://purl.obolibrary.org/obo/MP_0008549 abnormal circulating interferon-alpha level increase in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells http://purl.obolibrary.org/obo/MP_0008574 decreased circulating interferon-alpha level http://purl.obolibrary.org/obo/MP_0008549 abnormal circulating interferon-alpha level reduction in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells http://purl.obolibrary.org/obo/MP_0008575 increased circulating interferon-beta level http://purl.obolibrary.org/obo/MP_0008550 abnormal circulating interferon-beta level increase in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity http://purl.obolibrary.org/obo/MP_0008576 decreased circulating interferon-beta level http://purl.obolibrary.org/obo/MP_0008550 abnormal circulating interferon-beta level reduction in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity http://purl.obolibrary.org/obo/MP_0008577 increased circulating interferon-gamma level http://purl.obolibrary.org/obo/MP_0008551 abnormal circulating interferon-gamma level increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation http://purl.obolibrary.org/obo/MP_0008578 decreased circulating interferon-gamma level http://purl.obolibrary.org/obo/MP_0008551 abnormal circulating interferon-gamma level reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation http://purl.obolibrary.org/obo/MP_0008579 abnormal Purkinje cell differentiation http://purl.obolibrary.org/obo/MP_0009937 abnormal neuron differentiation atypical production of or inability to produce the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex http://purl.obolibrary.org/obo/MP_0008580 photoreceptor inner segment degeneration http://purl.obolibrary.org/obo/MP_0003730 abnormal photoreceptor inner segment morphology retrogressive pathologic change in the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region http://purl.obolibrary.org/obo/MP_0008581 disorganized photoreceptor inner segment http://purl.obolibrary.org/obo/MP_0003730 abnormal photoreceptor inner segment morphology derangement of the pattern of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region http://purl.obolibrary.org/obo/MP_0008582 short photoreceptor inner segment http://purl.obolibrary.org/obo/MP_0003730 abnormal photoreceptor inner segment morphology decreased length of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region http://purl.obolibrary.org/obo/MP_0008583 absent photoreceptor inner segment http://purl.obolibrary.org/obo/MP_0003730 abnormal photoreceptor inner segment morphology absence of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region http://purl.obolibrary.org/obo/MP_0008584 photoreceptor outer segment degeneration http://purl.obolibrary.org/obo/MP_0003729 abnormal photoreceptor outer segment morphology retrogressive pathologic change in the photoreceptor region that is rich in the visual pigment rhodopsin http://purl.obolibrary.org/obo/MP_0008585 absent photoreceptor outer segment http://purl.obolibrary.org/obo/MP_0003729 abnormal photoreceptor outer segment morphology absence of the photoreceptor region that is rich in the visual pigment rhodopsin http://purl.obolibrary.org/obo/MP_0008586 disorganized photoreceptor outer segment http://purl.obolibrary.org/obo/MP_0003729 abnormal photoreceptor outer segment morphology derangement of the pattern of the photoreceptor region that is rich in the visual pigment rhodopsin http://purl.obolibrary.org/obo/MP_0008587 short photoreceptor outer segment http://purl.obolibrary.org/obo/MP_0003729 abnormal photoreceptor outer segment morphology decreased length of the photoreceptor region that is rich in the visual pigment rhodopsin http://purl.obolibrary.org/obo/MP_0008588 abnormal circulating interleukin level http://purl.obolibrary.org/obo/MP_0010210 abnormal circulating cytokine level anomaly in the amount in the blood of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli http://purl.obolibrary.org/obo/MP_0008589 abnormal circulating interleukin-1 level http://purl.obolibrary.org/obo/MP_0008588 abnormal circulating interleukin level anomaly in the amount in the blood of a soluble factor produced by monocytes, macrophages and other cells, which activates T-lymphocytes and potentiates their response to mitogens or antigens http://purl.obolibrary.org/obo/MP_0008590 abnormal circulating interleukin-10 level http://purl.obolibrary.org/obo/MP_0008588 abnormal circulating interleukin level anomaly in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation http://purl.obolibrary.org/obo/MP_0008591 increased circulating interleukin-1 level http://purl.obolibrary.org/obo/MP_0008589 abnormal circulating interleukin-1 level increase in the amount in the blood of a soluble factor produced by monocytes, macrophages and other cells, which activates T-lymphocytes and potentiates their response to mitogens or antigens http://purl.obolibrary.org/obo/MP_0008592 decreased circulating interleukin-1 level http://purl.obolibrary.org/obo/MP_0008589 abnormal circulating interleukin-1 level reduction in the amount in the blood of a soluble factor produced by monocytes, macrophages and other cells, which activates T-lymphocytes and potentiates their response to mitogens or antigens http://purl.obolibrary.org/obo/MP_0008593 increased circulating interleukin-10 level http://purl.obolibrary.org/obo/MP_0008590 abnormal circulating interleukin-10 level increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation http://purl.obolibrary.org/obo/MP_0008594 decreased circulating interleukin-10 level http://purl.obolibrary.org/obo/MP_0008590 abnormal circulating interleukin-10 level reduction in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation http://purl.obolibrary.org/obo/MP_0008595 abnormal circulating interleukin-6 level http://purl.obolibrary.org/obo/MP_0008588 abnormal circulating interleukin level anomaly in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts http://purl.obolibrary.org/obo/MP_0008596 increased circulating interleukin-6 level http://purl.obolibrary.org/obo/MP_0008595 abnormal circulating interleukin-6 level increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts http://purl.obolibrary.org/obo/MP_0008597 decreased circulating interleukin-6 level http://purl.obolibrary.org/obo/MP_0008595 abnormal circulating interleukin-6 level reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts http://purl.obolibrary.org/obo/MP_0008598 abnormal circulating interleukin-2 level http://purl.obolibrary.org/obo/MP_0008588 abnormal circulating interleukin level anomaly in the amount in the blood of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes http://purl.obolibrary.org/obo/MP_0008599 increased circulating interleukin-2 level http://purl.obolibrary.org/obo/MP_0008598 abnormal circulating interleukin-2 level increase in the amount in the blood of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes http://purl.obolibrary.org/obo/MP_0008600 decreased circulating interleukin-2 level http://purl.obolibrary.org/obo/MP_0008598 abnormal circulating interleukin-2 level reduction in the amount in the blood of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes http://purl.obolibrary.org/obo/MP_0008601 abnormal circulating interleukin-4 level http://purl.obolibrary.org/obo/MP_0008588 abnormal circulating interleukin level anomaly in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells http://purl.obolibrary.org/obo/MP_0008602 increased circulating interleukin-4 level http://purl.obolibrary.org/obo/MP_0008601 abnormal circulating interleukin-4 level increase in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells http://purl.obolibrary.org/obo/MP_0008603 decreased circulating interleukin-4 level http://purl.obolibrary.org/obo/MP_0008601 abnormal circulating interleukin-4 level reduction in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells http://purl.obolibrary.org/obo/MP_0008604 abnormal circulating interleukin-7 level http://purl.obolibrary.org/obo/MP_0008588 abnormal circulating interleukin level anomaly in the amount in the blood of a cytokine produced by bone marrow stromal cells that promotes the growth of B-cell precursors and is co-mitogenic with interleukin-2 for mature T-cell activation http://purl.obolibrary.org/obo/MP_0008605 increased circulating interleukin-7 level http://purl.obolibrary.org/obo/MP_0008604 abnormal circulating interleukin-7 level increase in the amount in the blood of a cytokine produced by bone marrow stromal cells that promotes the growth of B-cell precursors and is co-mitogenic with interleukin-2 for mature T-cell activation http://purl.obolibrary.org/obo/MP_0008606 decreased circulating interleukin-7 level http://purl.obolibrary.org/obo/MP_0008604 abnormal circulating interleukin-7 level reduction in the amount in the blood of a cytokine produced by bone marrow stromal cells that promotes the growth of B-cell precursors and is co-mitogenic with interleukin-2 for mature T-cell activation http://purl.obolibrary.org/obo/MP_0008607 abnormal circulating interleukin-13 level http://purl.obolibrary.org/obo/MP_0008588 abnormal circulating interleukin level anomaly in the amount in the blood of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses http://purl.obolibrary.org/obo/MP_0008608 increased circulating interleukin-13 level http://purl.obolibrary.org/obo/MP_0008607 abnormal circulating interleukin-13 level increase in the amount in the blood of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses http://purl.obolibrary.org/obo/MP_0008609 decreased circulating interleukin-13 level http://purl.obolibrary.org/obo/MP_0008607 abnormal circulating interleukin-13 level reduction in the amount in the blood of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses http://purl.obolibrary.org/obo/MP_0008610 abnormal circulating interleukin-15 level http://purl.obolibrary.org/obo/MP_0008588 abnormal circulating interleukin level anomaly in the amount in the blood of a cytokine that stimulates the proliferation of T-cells and can induce proliferation and differentiation of B-cells; interleukin-15 shares biological activities with interleukin-2 http://purl.obolibrary.org/obo/MP_0008611 increased circulating interleukin-15 level http://purl.obolibrary.org/obo/MP_0008610 abnormal circulating interleukin-15 level increase in the amount in the blood of a cytokine that stimulates the proliferation of T-cells and can induce proliferation and differentiation of B-cells; interleukin-15 shares biological activities with interleukin-2 http://purl.obolibrary.org/obo/MP_0008612 decreased circulating interleukin-15 level http://purl.obolibrary.org/obo/MP_0008610 abnormal circulating interleukin-15 level reduction in the amount in the blood of a cytokine that stimulates the proliferation of T-cells and can induce proliferation and differentiation of B-cells; interleukin-15 shares biological activities with interleukin-2 http://purl.obolibrary.org/obo/MP_0008613 abnormal circulating interleukin-17 level http://purl.obolibrary.org/obo/MP_0008588 abnormal circulating interleukin level anomaly in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors http://purl.obolibrary.org/obo/MP_0008614 increased circulating interleukin-17 level http://purl.obolibrary.org/obo/MP_0008613 abnormal circulating interleukin-17 level increase in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors http://purl.obolibrary.org/obo/MP_0008615 decreased circulating interleukin-17 level http://purl.obolibrary.org/obo/MP_0008613 abnormal circulating interleukin-17 level reduction in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors http://purl.obolibrary.org/obo/MP_0008616 abnormal circulating interleukin-12 level http://purl.obolibrary.org/obo/MP_0008588 abnormal circulating interleukin level anomaly in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells http://purl.obolibrary.org/obo/MP_0008617 increased circulating interleukin-12 level http://purl.obolibrary.org/obo/MP_0008616 abnormal circulating interleukin-12 level increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells http://purl.obolibrary.org/obo/MP_0008618 decreased circulating interleukin-12 level http://purl.obolibrary.org/obo/MP_0008616 abnormal circulating interleukin-12 level reduction in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells http://purl.obolibrary.org/obo/MP_0008619 abnormal circulating interleukin-23 level http://purl.obolibrary.org/obo/MP_0008588 abnormal circulating interleukin level anomaly in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells http://purl.obolibrary.org/obo/MP_0008620 increased circulating interleukin-23 level http://purl.obolibrary.org/obo/MP_0008619 abnormal circulating interleukin-23 level increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells http://purl.obolibrary.org/obo/MP_0008621 decreased circulating interleukin-23 level http://purl.obolibrary.org/obo/MP_0008619 abnormal circulating interleukin-23 level reduction in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells http://purl.obolibrary.org/obo/MP_0008622 abnormal circulating interleukin-3 level http://purl.obolibrary.org/obo/MP_0008588 abnormal circulating interleukin level anomaly in the amount in the blood of a multilineage cell growth factor secreted by lymphocytes, epithelial cells and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells http://purl.obolibrary.org/obo/MP_0008623 increased circulating interleukin-3 level http://purl.obolibrary.org/obo/MP_0008622 abnormal circulating interleukin-3 level increase in the amount in the blood of a multilineage cell growth factor secreted by lymphocytes, epithelial cells and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells http://purl.obolibrary.org/obo/MP_0008624 decreased circulating interleukin-3 level http://purl.obolibrary.org/obo/MP_0008622 abnormal circulating interleukin-3 level reduction in the amount in the blood of a multilineage cell growth factor secreted by lymphocytes, epithelial cells and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells http://purl.obolibrary.org/obo/MP_0008625 abnormal circulating interleukin-5 level http://purl.obolibrary.org/obo/MP_0008588 abnormal circulating interleukin level anomaly in the amount in the blood of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells http://purl.obolibrary.org/obo/MP_0008626 increased circulating interleukin-5 level http://purl.obolibrary.org/obo/MP_0008625 abnormal circulating interleukin-5 level increase in the amount in the blood of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells http://purl.obolibrary.org/obo/MP_0008627 decreased circulating interleukin-5 level http://purl.obolibrary.org/obo/MP_0008625 abnormal circulating interleukin-5 level reduction in the amount in the blood of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells http://purl.obolibrary.org/obo/MP_0008628 abnormal circulating interleukin-9 level http://purl.obolibrary.org/obo/MP_0008588 abnormal circulating interleukin level anomaly in the amount in the blood of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells http://purl.obolibrary.org/obo/MP_0008629 increased circulating interleukin-9 level http://purl.obolibrary.org/obo/MP_0008628 abnormal circulating interleukin-9 level increase in the amount in the blood of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells http://purl.obolibrary.org/obo/MP_0008630 decreased circulating interleukin-9 level http://purl.obolibrary.org/obo/MP_0008628 abnormal circulating interleukin-9 level reduction in the amount in the blood of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells http://purl.obolibrary.org/obo/MP_0008631 abnormal circulating interleukin-16 level http://purl.obolibrary.org/obo/MP_0008588 abnormal circulating interleukin level anomaly in the amount in the blood of a cytokine produced by activated T-cells that stimulates the migration of CD4-positive lymphocytes and monocytes http://purl.obolibrary.org/obo/MP_0008632 increased circulating interleukin-16 level http://purl.obolibrary.org/obo/MP_0008631 abnormal circulating interleukin-16 level increase in the amount in the blood of a cytokine produced by activated T-cells that stimulates the migration of CD4-positive lymphocytes and monocytes http://purl.obolibrary.org/obo/MP_0008633 decreased circulating interleukin-16 level http://purl.obolibrary.org/obo/MP_0008631 abnormal circulating interleukin-16 level reduction in the amount in the blood of a cytokine produced by activated T-cells that stimulates the migration of CD4-positive lymphocytes and monocytes http://purl.obolibrary.org/obo/MP_0008634 abnormal circulating interleukin-18 level http://purl.obolibrary.org/obo/MP_0008588 abnormal circulating interleukin level anomaly in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity http://purl.obolibrary.org/obo/MP_0008635 increased circulating interleukin-18 level http://purl.obolibrary.org/obo/MP_0008634 abnormal circulating interleukin-18 level increase in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity http://purl.obolibrary.org/obo/MP_0008636 decreased circulating interleukin-18 level http://purl.obolibrary.org/obo/MP_0008634 abnormal circulating interleukin-18 level reduction in the amount in the blood of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity http://purl.obolibrary.org/obo/MP_0008637 abnormal circulating interleukin-1 alpha level http://purl.obolibrary.org/obo/MP_0008589 abnormal circulating interleukin-1 level anomaly in the amount in the blood of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active http://purl.obolibrary.org/obo/MP_0008638 increased circulating interleukin-1 alpha level http://purl.obolibrary.org/obo/MP_0008637 abnormal circulating interleukin-1 alpha level increase in the amount in the blood of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active http://purl.obolibrary.org/obo/MP_0008639 decreased circulating interleukin-1 alpha level http://purl.obolibrary.org/obo/MP_0008637 abnormal circulating interleukin-1 alpha level reduction in the amount in the blood of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active http://purl.obolibrary.org/obo/MP_0008640 abnormal circulating interleukin-1 beta level http://purl.obolibrary.org/obo/MP_0008589 abnormal circulating interleukin-1 level anomaly in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane http://purl.obolibrary.org/obo/MP_0008641 increased circulating interleukin-1 beta level http://purl.obolibrary.org/obo/MP_0008640 abnormal circulating interleukin-1 beta level increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane http://purl.obolibrary.org/obo/MP_0008642 decreased circulating interleukin-1 beta level http://purl.obolibrary.org/obo/MP_0008640 abnormal circulating interleukin-1 beta level reduction in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane http://purl.obolibrary.org/obo/MP_0008643 abnormal circulating interleukin-12a level http://purl.obolibrary.org/obo/MP_0008616 abnormal circulating interleukin-12 level anomaly in the amount in the blood of the p35 subunit of interleukin-12 http://purl.obolibrary.org/obo/MP_0008644 increased circulating interleukin-12a level http://purl.obolibrary.org/obo/MP_0008643 abnormal circulating interleukin-12a level increase in the amount in the blood of the p35 subunit of interleukin-12 http://purl.obolibrary.org/obo/MP_0008645 decreased circulating interleukin-12a level http://purl.obolibrary.org/obo/MP_0008643 abnormal circulating interleukin-12a level reduction in the amount in the blood of the p35 subunit of interleukin-12 http://purl.obolibrary.org/obo/MP_0008646 abnormal circulating interleukin-12b level http://purl.obolibrary.org/obo/MP_0008588 abnormal circulating interleukin level anomaly in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23 http://purl.obolibrary.org/obo/MP_0008647 increased circulating interleukin-12b level http://purl.obolibrary.org/obo/MP_0008646 abnormal circulating interleukin-12b level increase in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23 http://purl.obolibrary.org/obo/MP_0008648 decreased circulating interleukin-12b level http://purl.obolibrary.org/obo/MP_0008646 abnormal circulating interleukin-12b level reduction in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23 http://purl.obolibrary.org/obo/MP_0008649 abnormal circulating interleukin-23a level http://purl.obolibrary.org/obo/MP_0008619 abnormal circulating interleukin-23 level anomaly in the amount in the blood of the p19 subunit of interleukin-23 http://purl.obolibrary.org/obo/MP_0008650 abnormal interleukin-1 secretion http://purl.obolibrary.org/obo/MP_0008568 abnormal interleukin secretion anomaly in the production or release of a soluble factor produced by monocytes, macrophages and other cells, which activates T-lymphocytes and potentiates their response to mitogens or antigens http://purl.obolibrary.org/obo/MP_0008651 increased interleukin-1 secretion http://purl.obolibrary.org/obo/MP_0008650 abnormal interleukin-1 secretion increase in the production or release of a soluble factor produced by monocytes, macrophages and other cells, which activates T-lymphocytes and potentiates their response to mitogens or antigens http://purl.obolibrary.org/obo/MP_0008652 decreased interleukin-1 secretion http://purl.obolibrary.org/obo/MP_0008650 abnormal interleukin-1 secretion reduction in the production or release of a soluble factor produced by monocytes, macrophages and other cells, which activates T-lymphocytes and potentiates their response to mitogens or antigens http://purl.obolibrary.org/obo/MP_0008653 abnormal interleukin-1 alpha secretion http://purl.obolibrary.org/obo/MP_0008650 abnormal interleukin-1 secretion anomaly in the production or release of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active http://purl.obolibrary.org/obo/MP_0008654 increased interleukin-1 alpha secretion http://purl.obolibrary.org/obo/MP_0008653 abnormal interleukin-1 alpha secretion increase in the production or release of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active http://purl.obolibrary.org/obo/MP_0008655 decreased interleukin-1 alpha secretion http://purl.obolibrary.org/obo/MP_0008653 abnormal interleukin-1 alpha secretion reduction in the production or release of an interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form; both membrane-bound and secreted forms of interleukin-1alpha are biologically active http://purl.obolibrary.org/obo/MP_0008656 abnormal interleukin-1 beta secretion http://purl.obolibrary.org/obo/MP_0008650 abnormal interleukin-1 secretion anomaly in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane http://purl.obolibrary.org/obo/MP_0008657 increased interleukin-1 beta secretion http://purl.obolibrary.org/obo/MP_0008656 abnormal interleukin-1 beta secretion increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane http://purl.obolibrary.org/obo/MP_0008658 decreased interleukin-1 beta secretion http://purl.obolibrary.org/obo/MP_0008656 abnormal interleukin-1 beta secretion reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane http://purl.obolibrary.org/obo/MP_0008659 abnormal interleukin-10 secretion http://purl.obolibrary.org/obo/MP_0008568 abnormal interleukin secretion anomaly in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation http://purl.obolibrary.org/obo/MP_0008660 increased interleukin-10 secretion http://purl.obolibrary.org/obo/MP_0008659 abnormal interleukin-10 secretion increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation http://purl.obolibrary.org/obo/MP_0008661 decreased interleukin-10 secretion http://purl.obolibrary.org/obo/MP_0008659 abnormal interleukin-10 secretion reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation http://purl.obolibrary.org/obo/MP_0008662 abnormal interleukin-12 secretion http://purl.obolibrary.org/obo/MP_0008568 abnormal interleukin secretion anomaly in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells http://purl.obolibrary.org/obo/MP_0008663 increased interleukin-12 secretion http://purl.obolibrary.org/obo/MP_0008662 abnormal interleukin-12 secretion increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells http://purl.obolibrary.org/obo/MP_0008664 decreased interleukin-12 secretion http://purl.obolibrary.org/obo/MP_0008662 abnormal interleukin-12 secretion reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells http://purl.obolibrary.org/obo/MP_0008665 abnormal interleukin-12a secretion http://purl.obolibrary.org/obo/MP_0008662 abnormal interleukin-12 secretion anomaly in the production or release of the p35 subunit of interleukin-12 http://purl.obolibrary.org/obo/MP_0008666 increased interleukin-12a secretion http://purl.obolibrary.org/obo/MP_0008665 abnormal interleukin-12a secretion increase in the production or release of the p35 subunit of interleukin-12 http://purl.obolibrary.org/obo/MP_0008667 decreased interleukin-12a secretion http://purl.obolibrary.org/obo/MP_0008665 abnormal interleukin-12a secretion reduction in the production or release of the p35 subunit of interleukin-12 http://purl.obolibrary.org/obo/MP_0008668 abnormal interleukin-12b secretion http://purl.obolibrary.org/obo/MP_0008568 abnormal interleukin secretion anomaly in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23 http://purl.obolibrary.org/obo/MP_0008669 increased interleukin-12b secretion http://purl.obolibrary.org/obo/MP_0008668 abnormal interleukin-12b secretion increase in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23 http://purl.obolibrary.org/obo/MP_0008670 decreased interleukin-12b secretion http://purl.obolibrary.org/obo/MP_0008668 abnormal interleukin-12b secretion reduction in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23 http://purl.obolibrary.org/obo/MP_0008671 abnormal interleukin-13 secretion http://purl.obolibrary.org/obo/MP_0008568 abnormal interleukin secretion anomaly in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses http://purl.obolibrary.org/obo/MP_0008672 increased interleukin-13 secretion http://purl.obolibrary.org/obo/MP_0008671 abnormal interleukin-13 secretion increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses http://purl.obolibrary.org/obo/MP_0008673 decreased interleukin-13 secretion http://purl.obolibrary.org/obo/MP_0008671 abnormal interleukin-13 secretion reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses http://purl.obolibrary.org/obo/MP_0008674 abnormal interleukin-15 secretion http://purl.obolibrary.org/obo/MP_0008568 abnormal interleukin secretion anomaly in the production or release of a cytokine that stimulates the proliferation of T-cells and can induce proliferation and differentiation of B-cells; interleukin-15 shares biological activities with interleukin-2 http://purl.obolibrary.org/obo/MP_0008675 increased interleukin-15 secretion http://purl.obolibrary.org/obo/MP_0008674 abnormal interleukin-15 secretion increase in the production or release of a cytokine that stimulates the proliferation of T-cells and can induce proliferation and differentiation of B-cells; interleukin-15 shares biological activities with interleukin-2 http://purl.obolibrary.org/obo/MP_0008676 decreased interleukin-15 secretion http://purl.obolibrary.org/obo/MP_0008674 abnormal interleukin-15 secretion reduction in the production or release of a cytokine that stimulates the proliferation of T-cells and can induce proliferation and differentiation of B-cells; interleukin-15 shares biological activities with interleukin-2 http://purl.obolibrary.org/obo/MP_0008677 abnormal interleukin-16 secretion http://purl.obolibrary.org/obo/MP_0008568 abnormal interleukin secretion anomaly in the production or release of a cytokine produced by activated T-cells that stimulates the migration of CD4-positive lymphocytes and monocytes http://purl.obolibrary.org/obo/MP_0008678 increased interleukin-16 secretion http://purl.obolibrary.org/obo/MP_0008677 abnormal interleukin-16 secretion increase in the production or release of a cytokine produced by activated T-cells that stimulates the migration of CD4-positive lymphocytes and monocytes http://purl.obolibrary.org/obo/MP_0008679 decreased interleukin-16 secretion http://purl.obolibrary.org/obo/MP_0008677 abnormal interleukin-16 secretion reduction in the production or release of a cytokine produced by activated T-cells that stimulates the migration of CD4-positive lymphocytes and monocytes http://purl.obolibrary.org/obo/MP_0008680 abnormal interleukin-17 secretion http://purl.obolibrary.org/obo/MP_0008568 abnormal interleukin secretion anomaly in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors http://purl.obolibrary.org/obo/MP_0008681 increased interleukin-17 secretion http://purl.obolibrary.org/obo/MP_0008680 abnormal interleukin-17 secretion increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors http://purl.obolibrary.org/obo/MP_0008682 decreased interleukin-17 secretion http://purl.obolibrary.org/obo/MP_0008680 abnormal interleukin-17 secretion reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors http://purl.obolibrary.org/obo/MP_0008683 abnormal interleukin-18 secretion http://purl.obolibrary.org/obo/MP_0008568 abnormal interleukin secretion anomaly in the production or release of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity http://purl.obolibrary.org/obo/MP_0008684 increased interleukin-18 secretion http://purl.obolibrary.org/obo/MP_0008683 abnormal interleukin-18 secretion increase in the production or release of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity http://purl.obolibrary.org/obo/MP_0008685 decreased interleukin-18 secretion http://purl.obolibrary.org/obo/MP_0008683 abnormal interleukin-18 secretion reduction in the production or release of a cytokine which enhances the cytotoxic activity of NK cells and cytotoxic T-cells and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity http://purl.obolibrary.org/obo/MP_0008686 abnormal interleukin-2 secretion http://purl.obolibrary.org/obo/MP_0008568 abnormal interleukin secretion anomaly in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes http://purl.obolibrary.org/obo/MP_0008687 increased interleukin-2 secretion http://purl.obolibrary.org/obo/MP_0008686 abnormal interleukin-2 secretion increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes http://purl.obolibrary.org/obo/MP_0008688 decreased interleukin-2 secretion http://purl.obolibrary.org/obo/MP_0008686 abnormal interleukin-2 secretion reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes http://purl.obolibrary.org/obo/MP_0008689 abnormal interleukin-23 secretion http://purl.obolibrary.org/obo/MP_0008568 abnormal interleukin secretion anomaly in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells http://purl.obolibrary.org/obo/MP_0008690 increased interleukin-23 secretion http://purl.obolibrary.org/obo/MP_0008689 abnormal interleukin-23 secretion increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells http://purl.obolibrary.org/obo/MP_0008691 decreased interleukin-23 secretion http://purl.obolibrary.org/obo/MP_0008689 abnormal interleukin-23 secretion reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells http://purl.obolibrary.org/obo/MP_0008692 abnormal interleukin-23a secretion http://purl.obolibrary.org/obo/MP_0008689 abnormal interleukin-23 secretion anomaly in the production or release of the p19 subunit of interleukin-23 http://purl.obolibrary.org/obo/MP_0008693 increased interleukin-23a secretion http://purl.obolibrary.org/obo/MP_0008692 abnormal interleukin-23a secretion increase in the production or release of the p19 subunit of interleukin-23 http://purl.obolibrary.org/obo/MP_0008694 decreased interleukin-23a secretion http://purl.obolibrary.org/obo/MP_0008692 abnormal interleukin-23a secretion reduction in the production or release of the p19 subunit of interleukin-23 http://purl.obolibrary.org/obo/MP_0008695 abnormal interleukin-3 secretion http://purl.obolibrary.org/obo/MP_0008568 abnormal interleukin secretion anomaly in the production or release of a multilineage cell growth factor secreted by lymphocytes, epithelial cells and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells http://purl.obolibrary.org/obo/MP_0008696 increased interleukin-3 secretion http://purl.obolibrary.org/obo/MP_0008695 abnormal interleukin-3 secretion increase in the production or release of a multilineage cell growth factor secreted by lymphocytes, epithelial cells and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells http://purl.obolibrary.org/obo/MP_0008697 decreased interleukin-3 secretion http://purl.obolibrary.org/obo/MP_0008695 abnormal interleukin-3 secretion reduction in the production or release of a multilineage cell growth factor secreted by lymphocytes, epithelial cells and astrocytes which stimulates clonal proliferation and differentiation of various types of blood and tissue cells http://purl.obolibrary.org/obo/MP_0008698 abnormal interleukin-4 secretion http://purl.obolibrary.org/obo/MP_0008568 abnormal interleukin secretion anomaly in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells http://purl.obolibrary.org/obo/MP_0008699 increased interleukin-4 secretion http://purl.obolibrary.org/obo/MP_0008698 abnormal interleukin-4 secretion increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells http://purl.obolibrary.org/obo/MP_0008700 decreased interleukin-4 secretion http://purl.obolibrary.org/obo/MP_0008698 abnormal interleukin-4 secretion reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells http://purl.obolibrary.org/obo/MP_0008701 abnormal interleukin-5 secretion http://purl.obolibrary.org/obo/MP_0008568 abnormal interleukin secretion anomaly in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells http://purl.obolibrary.org/obo/MP_0008702 increased interleukin-5 secretion http://purl.obolibrary.org/obo/MP_0008701 abnormal interleukin-5 secretion increase in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells http://purl.obolibrary.org/obo/MP_0008703 decreased interleukin-5 secretion http://purl.obolibrary.org/obo/MP_0008701 abnormal interleukin-5 secretion reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells http://purl.obolibrary.org/obo/MP_0008704 abnormal interleukin-6 secretion http://purl.obolibrary.org/obo/MP_0008568 abnormal interleukin secretion anomaly in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts http://purl.obolibrary.org/obo/MP_0008705 increased interleukin-6 secretion http://purl.obolibrary.org/obo/MP_0008704 abnormal interleukin-6 secretion increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts http://purl.obolibrary.org/obo/MP_0008706 decreased interleukin-6 secretion http://purl.obolibrary.org/obo/MP_0008704 abnormal interleukin-6 secretion reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts http://purl.obolibrary.org/obo/MP_0008707 abnormal interleukin-7 secretion http://purl.obolibrary.org/obo/MP_0008568 abnormal interleukin secretion anomaly in the production or release of a cytokine produced by bone marrow stromal cells that promotes the growth of B-cell precursors and is co-mitogenic with interleukin-2 for mature T-cell activation http://purl.obolibrary.org/obo/MP_0008708 increased interleukin-7 secretion http://purl.obolibrary.org/obo/MP_0008707 abnormal interleukin-7 secretion increase in the production or release of a cytokine produced by bone marrow stromal cells that promotes the growth of B-cell precursors and is co-mitogenic with interleukin-2 for mature T-cell activation http://purl.obolibrary.org/obo/MP_0008709 decreased interleukin-7 secretion http://purl.obolibrary.org/obo/MP_0008707 abnormal interleukin-7 secretion reduction in the production or release of a cytokine produced by bone marrow stromal cells that promotes the growth of B-cell precursors and is co-mitogenic with interleukin-2 for mature T-cell activation http://purl.obolibrary.org/obo/MP_0008710 abnormal interleukin-9 secretion http://purl.obolibrary.org/obo/MP_0008568 abnormal interleukin secretion anomaly in the production or release of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells http://purl.obolibrary.org/obo/MP_0008711 increased interleukin-9 secretion http://purl.obolibrary.org/obo/MP_0008710 abnormal interleukin-9 secretion increase in the production or release of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells http://purl.obolibrary.org/obo/MP_0008712 decreased interleukin-9 secretion http://purl.obolibrary.org/obo/MP_0008710 abnormal interleukin-9 secretion reduction in the production or release of a multifunctional cytokine secreted by primarily by activated TH2 cells that may play a role as a regulator of allergic inflammation, and has been shown to enhance the growth and differentiation of mast cells, and can act on a variety of other immune cells http://purl.obolibrary.org/obo/MP_0008713 abnormal cytokine level http://purl.obolibrary.org/obo/MP_0008835 abnormal intercellular signaling peptide or protein level deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells http://purl.obolibrary.org/obo/MP_0008714 increased lung carcinoma incidence http://purl.obolibrary.org/obo/MP_0008014 increased lung tumor incidence greater than the expected number of a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0008715 increased lung small cell carcinoma incidence http://purl.obolibrary.org/obo/MP_0008714 increased lung carcinoma incidence greater than the expected number of an anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0008717 increased lung squamous cell carcinoma incidence http://purl.obolibrary.org/obo/MP_0008716 increased lung non-small cell carcinoma incidence greater than the expected number of a lung carcinoma derived from stratified squamous epithelium, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0008718 increased lung large cell carcinoma incidence http://purl.obolibrary.org/obo/MP_0008716 increased lung non-small cell carcinoma incidence greater than the expected number of a bronchogenic tumor of undifferentiated (anaplastic) cells of large size, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0008719 impaired neutrophil recruitment http://purl.obolibrary.org/obo/MP_0002463 abnormal neutrophil physiology reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions http://purl.obolibrary.org/obo/MP_0008720 impaired neutrophil chemotaxis http://purl.obolibrary.org/obo/MP_0011518 abnormal cell chemotaxis defect in the movement of neutrophils guided by a specific chemical concentration gradient http://purl.obolibrary.org/obo/MP_0008721 abnormal chemokine level http://purl.obolibrary.org/obo/MP_0008713 abnormal cytokine level deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes http://purl.obolibrary.org/obo/MP_0008722 abnormal chemokine secretion http://purl.obolibrary.org/obo/MP_0003009 abnormal cytokine secretion anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes http://purl.obolibrary.org/obo/MP_0008723 impaired eosinophil recruitment http://purl.obolibrary.org/obo/MP_0002465 abnormal eosinophil physiology reduced diffusion or accumulation of eosinophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions http://purl.obolibrary.org/obo/MP_0008724 impaired eosinophil chemotaxis http://purl.obolibrary.org/obo/MP_0011518 abnormal cell chemotaxis defect in the movement of eosinophils guided by a specific chemical concentration gradient http://purl.obolibrary.org/obo/MP_0008725 enlarged heart atrium http://purl.obolibrary.org/obo/MP_0003105 abnormal heart atrium morphology increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation http://purl.obolibrary.org/obo/MP_0008726 enlarged heart left atrium http://purl.obolibrary.org/obo/MP_0008725 enlarged heart atrium increased size of the left upper chamber of the heart http://purl.obolibrary.org/obo/MP_0008727 enlarged heart right atrium http://purl.obolibrary.org/obo/MP_0008725 enlarged heart atrium increased size of the right upper chamber of the heart http://purl.obolibrary.org/obo/MP_0008728 increased memory B cell number http://purl.obolibrary.org/obo/MP_0008210 increased mature B cell number greater number of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin http://purl.obolibrary.org/obo/MP_0008729 decreased memory B cell number http://purl.obolibrary.org/obo/MP_0008211 decreased mature B cell number reduced number of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin http://purl.obolibrary.org/obo/MP_0008730 fused phalanges http://purl.obolibrary.org/obo/MP_0005306 abnormal phalanx morphology anomaly of the long bones of the digits resulting in some or all the bones being joined together http://purl.obolibrary.org/obo/MP_0008731 abnormal hair shaft melanin granule morphology http://purl.obolibrary.org/obo/MP_0005075 abnormal melanosome morphology any structural anomaly of pigment polymers in the hair shaft http://purl.obolibrary.org/obo/MP_0008732 reduced hair shaft melanin granule number http://purl.obolibrary.org/obo/MP_0008731 abnormal hair shaft melanin granule morphology the number of pigment polymers in the hair shaft is less than normal http://purl.obolibrary.org/obo/MP_0008733 abnormal hair shaft melanin granule distribution http://purl.obolibrary.org/obo/MP_0008731 abnormal hair shaft melanin granule morphology disruption in the regular arrangement of pigment polymers in the hair shaft http://purl.obolibrary.org/obo/MP_0008734 decreased susceptibility to endotoxin shock http://purl.obolibrary.org/obo/MP_0005087 decreased acute inflammation less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death http://purl.obolibrary.org/obo/MP_0008735 increased susceptibility to endotoxin shock http://purl.obolibrary.org/obo/MP_0005088 increased acute inflammation more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death http://purl.obolibrary.org/obo/MP_0008736 micromelia http://purl.obolibrary.org/obo/MP_0000547 short limbs disproportionately short or small limbs http://purl.obolibrary.org/obo/MP_0008737 abnormal spleen physiology http://purl.obolibrary.org/obo/MP_0003762 abnormal immune organ physiology any functional anomaly of the organ that filters blood and stores red corpuscles and platelets http://purl.obolibrary.org/obo/MP_0008738 abnormal liver iron level http://purl.obolibrary.org/obo/MP_0001770 abnormal iron level anomaly in the amount of iron present in the liver tissue http://purl.obolibrary.org/obo/MP_0008739 abnormal spleen iron level http://purl.obolibrary.org/obo/MP_0001770 abnormal iron level anomaly in the amount of iron present in the spleen tissue http://purl.obolibrary.org/obo/MP_0008740 abnormal intestinal iron level http://purl.obolibrary.org/obo/MP_0001770 abnormal iron level anomaly in the amount of iron present in the large or small intestinal tissue http://purl.obolibrary.org/obo/MP_0008741 abnormal heart iron level http://purl.obolibrary.org/obo/MP_0001770 abnormal iron level anomaly in the amount of iron present in the heart tissue http://purl.obolibrary.org/obo/MP_0008742 abnormal kidney iron level http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology anomaly in the amount of iron present in the kidney tissue http://purl.obolibrary.org/obo/MP_0008743 decreased liver iron level http://purl.obolibrary.org/obo/MP_0008738 abnormal liver iron level reduction in the amount of iron present in the liver tissue http://purl.obolibrary.org/obo/MP_0008744 abnormal B cell anergy http://purl.obolibrary.org/obo/MP_0005004 abnormal lymphocyte anergy any anomaly in the process contributing to anergy in B cells, a state of functional inactivation which is part of B cell tolerance induction http://purl.obolibrary.org/obo/MP_0008745 abnormal central B cell anergy http://purl.obolibrary.org/obo/MP_0008744 abnormal B cell anergy any anomaly of the processes of B cell anergy that occur in the bone marrow http://purl.obolibrary.org/obo/MP_0008746 abnormal peripheral B cell anergy http://purl.obolibrary.org/obo/MP_0008744 abnormal B cell anergy any anomaly of the processes of B cell anergy that occur outside the bone marrow http://purl.obolibrary.org/obo/MP_0008747 abnormal T cell anergy http://purl.obolibrary.org/obo/MP_0005004 abnormal lymphocyte anergy any anomaly in the process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction http://purl.obolibrary.org/obo/MP_0008748 abnormal central T cell anergy http://purl.obolibrary.org/obo/MP_0008747 abnormal T cell anergy any anomaly of the processes of T cell anergy that occur in the thymus http://purl.obolibrary.org/obo/MP_0008749 abnormal peripheral T cell anergy http://purl.obolibrary.org/obo/MP_0008747 abnormal T cell anergy any anomaly of the processes of T cell anergy that occur outside the thymus http://purl.obolibrary.org/obo/MP_0008750 abnormal interferon level http://purl.obolibrary.org/obo/MP_0008713 abnormal cytokine level deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions http://purl.obolibrary.org/obo/MP_0008751 abnormal interleukin level http://purl.obolibrary.org/obo/MP_0008713 abnormal cytokine level deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli http://purl.obolibrary.org/obo/MP_0008752 abnormal tumor necrosis factor level http://purl.obolibrary.org/obo/MP_0008713 abnormal cytokine level deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium http://purl.obolibrary.org/obo/MP_0008753 abnormal osteocyte morphology http://purl.obolibrary.org/obo/MP_0004986 abnormal osteoblast morphology any structural anomaly of a mature osteoblast that has become embedded in the bone matrix (osteoid) in small cavities called lacuna and is connected to adjacent osteocytes via protoplasmic projections called canaliculi http://purl.obolibrary.org/obo/MP_0008754 abnormal T cell receptor V(D)J recombination http://purl.obolibrary.org/obo/MP_0002145 abnormal T cell differentiation any anomaly in the process by which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus http://purl.obolibrary.org/obo/MP_0008755 abnormal immunoglobulin V(D)J recombination http://purl.obolibrary.org/obo/MP_0002144 abnormal B cell differentiation any anomaly in the process by which immunoglobulin V, D, and J or V and J gene segments, depending on the specific locus, are recombined within a single locus http://purl.obolibrary.org/obo/MP_0008756 abnormal T cell receptor alpha chain V-J recombination http://purl.obolibrary.org/obo/MP_0008754 abnormal T cell receptor V(D)J recombination any anomaly in the process by which V and J gene segments of the T cell receptor alpha chain are recombined http://purl.obolibrary.org/obo/MP_0008757 abnormal T cell receptor gamma chain V-J recombination http://purl.obolibrary.org/obo/MP_0008754 abnormal T cell receptor V(D)J recombination any anomaly in the process by which V and J gene segments of the T cell receptor gamma chain are recombined http://purl.obolibrary.org/obo/MP_0008758 abnormal T cell receptor beta chain V(D)J recombination http://purl.obolibrary.org/obo/MP_0008754 abnormal T cell receptor V(D)J recombination any anomaly in the process by which V, D, and J segments of the T cell receptor beta chain are recombined http://purl.obolibrary.org/obo/MP_0008759 abnormal T cell receptor delta chain V(D)J recombination http://purl.obolibrary.org/obo/MP_0008754 abnormal T cell receptor V(D)J recombination any anomaly in the process by which V, D, and J segments of the T cell receptor delta chain are recombined http://purl.obolibrary.org/obo/MP_0008760 abnormal immunoglobulin heavy chain V(D)J recombination http://purl.obolibrary.org/obo/MP_0008755 abnormal immunoglobulin V(D)J recombination any anomaly in the process by which V, D, and J gene segments of the immunoglobulin heavy chain are recombined http://purl.obolibrary.org/obo/MP_0008761 abnormal immunoglobulin light chain V-J recombination http://purl.obolibrary.org/obo/MP_0008755 abnormal immunoglobulin V(D)J recombination any anomaly in the process by which V and J gene segments of the immunoglobulin light chain are recombined http://purl.obolibrary.org/obo/MP_0008762 embryonic lethality http://purl.obolibrary.org/obo/MP_0002080 prenatal lethality death of an animal within the embryonic period prior to organogenesis (Mus: prior to E14) http://purl.obolibrary.org/obo/MP_0008763 abnormal mast cell degranulation http://purl.obolibrary.org/obo/MP_0002423 abnormal mast cell physiology abnormalities in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell http://purl.obolibrary.org/obo/MP_0008764 increased mast cell degranulation http://purl.obolibrary.org/obo/MP_0008763 abnormal mast cell degranulation increase in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell http://purl.obolibrary.org/obo/MP_0008765 decreased mast cell degranulation http://purl.obolibrary.org/obo/MP_0008763 abnormal mast cell degranulation reduction in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell http://purl.obolibrary.org/obo/MP_0008766 abnormal B cell receptor editing http://purl.obolibrary.org/obo/MP_0002144 abnormal B cell differentiation any anomaly in the process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor http://purl.obolibrary.org/obo/MP_0008767 abnormal hair medullary septa cells http://purl.obolibrary.org/obo/MP_0003812 abnormal hair medulla septa-forming cells of hair medulla are abnormal in size or arrangement http://purl.obolibrary.org/obo/MP_0008768 abnormal hair medulla air spaces http://purl.obolibrary.org/obo/MP_0003812 abnormal hair medulla air spaces between septa-forming cells of hair medulla are larger or smaller than normal http://purl.obolibrary.org/obo/MP_0008769 abnormal plasmacytoid dendritic cell physiology http://purl.obolibrary.org/obo/MP_0002376 abnormal dendritic cell physiology any functional anomaly of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli; plasmacytoid dendritic cells are found in the thymic medulla and lymph node T cell areas and are responsible for immune tolerance http://purl.obolibrary.org/obo/MP_0008770 decreased survivor rate http://purl.obolibrary.org/obo/MP_0010831 partial lethality a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls http://purl.obolibrary.org/obo/MP_0008771 elongated vertebral column http://purl.obolibrary.org/obo/MP_0004703 abnormal vertebral column morphology increased rostral-caudal length of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord http://purl.obolibrary.org/obo/MP_0008772 increased heart ventricle size http://purl.obolibrary.org/obo/MP_0005294 abnormal heart ventricle morphology increased average size of the heart ventricles compared to the average for a particular population http://purl.obolibrary.org/obo/MP_0008775 abnormal heart ventricle pressure http://purl.obolibrary.org/obo/MP_0001544 abnormal cardiovascular system physiology any anomaly in the pressure within a cardiac ventricle http://purl.obolibrary.org/obo/MP_0008776 increased right ventricle peak pressure http://purl.obolibrary.org/obo/MP_0010755 abnormal heart right ventricle pressure increase in the difference between right ventricular systolic and diastolic pressures http://purl.obolibrary.org/obo/MP_0008777 increased right ventricle diastolic pressure http://purl.obolibrary.org/obo/MP_0010755 abnormal heart right ventricle pressure increase in the pressure of the right ventricle between heart beats when the heart is relaxed http://purl.obolibrary.org/obo/MP_0008778 abnormal lymphangiogenesis http://purl.obolibrary.org/obo/MP_0001879 abnormal lymphatic vessel morphology any anomaly in the formation of lymphatic vessels from pre-existing lymphatic vessels http://purl.obolibrary.org/obo/MP_0008780 increased pancreatic acinar cell carcinoma incidence http://purl.obolibrary.org/obo/MP_0009153 increased pancreas tumor incidence greater than the expected number of an adenocarcinoma arising from cells of the pancreas that secrete digestive enzymes, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0008781 abnormal B cell apoptosis http://purl.obolibrary.org/obo/MP_0002459 abnormal B cell physiology change in the timing or the number of B cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0008782 increased B cell apoptosis http://purl.obolibrary.org/obo/MP_0008781 abnormal B cell apoptosis increase in the timing or the number of B cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0008783 decreased B cell apoptosis http://purl.obolibrary.org/obo/MP_0008781 abnormal B cell apoptosis reduction in the timing or the number of B cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0008784 craniorachischisis http://purl.obolibrary.org/obo/MP_0002151 abnormal neural tube morphology/development the most severe form of neural tube defect leaving the neural tube open from the midbrain or rostral hindbrain to the base of the spine; in mammals, craniorachischisis arises as a failure of a de novo closure event occurring during primary neurulation at the boundary of the future hindbrain and cervical spine (day 22 postfertilization in humans and E8.5 in mice); craniorachischisis totalis, the most complete form of craniorachischisis, presents anencephaly and total spina bifida together and is lethal http://purl.obolibrary.org/obo/MP_0008785 abnormal sternum manubrium morphology http://purl.obolibrary.org/obo/MP_0000157 abnormal sternum morphology any structural anomaly of the broad, handle-like part of the sternum which articulates with the clavicles and the first two pairs of ribs http://purl.obolibrary.org/obo/MP_0008786 abnormal hindgut morphology http://purl.obolibrary.org/obo/MP_0003119 abnormal digestive system development any structural anomaly of the caudal portion of the primitive digestive tube of the embryo http://purl.obolibrary.org/obo/MP_0008787 abnormal tailgut morphology http://purl.obolibrary.org/obo/MP_0003119 abnormal digestive system development any structural anomaly of the extension of the hindgut of the primitive digestive tube of the embryo, caudal to the location of the anal opening http://purl.obolibrary.org/obo/MP_0008788 abnormal fetal cardiomyocyte morphology http://purl.obolibrary.org/obo/MP_0000267 abnormal heart development any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes http://purl.obolibrary.org/obo/MP_0008789 abnormal olfactory epithelium morphology http://purl.obolibrary.org/obo/MP_0005499 abnormal olfactory system morphology any structural anomaly of the epithelial cells that line the interior of the nose http://purl.obolibrary.org/obo/MP_0008790 abnormal NK cell degranulation http://purl.obolibrary.org/obo/MP_0011719 abnormal natural killer cell mediated cytotoxicity anomaly in the exocytosis of secretory granules containing preformed mediators, such as perforin and granzyme, from NK cells http://purl.obolibrary.org/obo/MP_0008791 decreased NK cell degranulation http://purl.obolibrary.org/obo/MP_0008790 abnormal NK cell degranulation reduction in the exocytosis of secretory granules containing preformed mediators, such as perforin and granzyme, from NK cells http://purl.obolibrary.org/obo/MP_0008792 increased NK cell degranulation http://purl.obolibrary.org/obo/MP_0008790 abnormal NK cell degranulation increase in the exocytosis of secretory granules containing preformed mediators, such as perforin and granzyme, from NK cells http://purl.obolibrary.org/obo/MP_0008793 abnormal lens epithelium apoptosis http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology anomaly in the number of lens epithelial cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0008794 increased lens epithelium apoptosis http://purl.obolibrary.org/obo/MP_0008793 abnormal lens epithelium apoptosis increase in the number of lens epithelial cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0008795 abnormal lens fiber apoptosis http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology anomaly in the number of lens fibers cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0008796 increased lens fiber apoptosis http://purl.obolibrary.org/obo/MP_0008795 abnormal lens fiber apoptosis increase in the number of lens fibers cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0008798 lateral facial cleft http://purl.obolibrary.org/obo/MP_0008797 facial cleft presence of a primitive oral fissure (macrostomia) that extends into the anlage region of the ears, between the 1st and 2nd pharyngeal arches http://purl.obolibrary.org/obo/MP_0008799 oblique facial cleft http://purl.obolibrary.org/obo/MP_0008797 facial cleft presence of a facial fissure that runs from the lower lid edge to the lower edge of the nasal opening that results from a deficient fusion of the epithelium of the lacrimonasal duct http://purl.obolibrary.org/obo/MP_0008800 increased small intestinal crypt cell apoptosis http://purl.obolibrary.org/obo/MP_0010156 abnormal small intestinal crypt cell physiology increase in the number of small intestinal crypt cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0008802 abnormal intestinal smooth muscle morphology http://purl.obolibrary.org/obo/MP_0000767 abnormal smooth muscle morphology any structural anomaly of the nonstriated, involuntary muscle tissue lining the intestine http://purl.obolibrary.org/obo/MP_0008803 abnormal placental labyrinth vasculature morphology http://purl.obolibrary.org/obo/MP_0003231 abnormal placenta vasculature any structural anomaly of blood vessels of the layer of the placenta where embryonic and maternal blood exchange nutrients and waste products http://purl.obolibrary.org/obo/MP_0008804 abnormal circulating amylase level http://purl.obolibrary.org/obo/MP_0001570 abnormal circulating enzyme level any anomaly in the concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood http://purl.obolibrary.org/obo/MP_0008805 decreased circulating amylase level http://purl.obolibrary.org/obo/MP_0008804 abnormal circulating amylase level reduction in the concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood http://purl.obolibrary.org/obo/MP_0008806 increased circulating amylase level http://purl.obolibrary.org/obo/MP_0008804 abnormal circulating amylase level greater concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood http://purl.obolibrary.org/obo/MP_0008807 increased liver iron level http://purl.obolibrary.org/obo/MP_0008738 abnormal liver iron level increase in the amount of iron present in the liver tissue http://purl.obolibrary.org/obo/MP_0008808 decreased spleen iron level http://purl.obolibrary.org/obo/MP_0008739 abnormal spleen iron level reduction in the amount of iron present in the spleen tissue http://purl.obolibrary.org/obo/MP_0008809 increased spleen iron level http://purl.obolibrary.org/obo/MP_0008739 abnormal spleen iron level increase in the amount of iron present in the spleen tissue http://purl.obolibrary.org/obo/MP_0008810 increased circulating iron level http://purl.obolibrary.org/obo/MP_0004152 abnormal circulating iron level elevation in the concentration of iron in the blood http://purl.obolibrary.org/obo/MP_0008811 abnormal brain iron level http://purl.obolibrary.org/obo/MP_0002152 abnormal brain morphology any anomaly in the amount of iron present in the brain tissue http://purl.obolibrary.org/obo/MP_0008812 abnormal rostrocaudal coat patterning http://purl.obolibrary.org/obo/MP_0002075 abnormal coat/hair pigmentation irregular or unusual pigmentation pattern of the rostral-to-caudal axis compared to control animals http://purl.obolibrary.org/obo/MP_0008814 decreased nerve conduction velocity http://purl.obolibrary.org/obo/MP_0005403 abnormal nerve conduction decrease in the rate at which an electrical impulse travels through a nerve http://purl.obolibrary.org/obo/MP_0008815 anterior staphyloma http://purl.obolibrary.org/obo/MP_0005193 abnormal anterior eye segment morphology any structural anomaly resulting in bulging near the anterior pole of the eyeball http://purl.obolibrary.org/obo/MP_0008816 petechiae http://purl.obolibrary.org/obo/MP_0011514 skin hemorrhage very small blood spots or splotches that appear especially in skin as a result of localized hemorrhage http://purl.obolibrary.org/obo/MP_0008817 hematoma http://purl.obolibrary.org/obo/MP_0001914 hemorrhage an abnormal localized accumulation of clotted or partially clotted blood in an organ or a soft tissue space as a result of localized hemorrhage http://purl.obolibrary.org/obo/MP_0008818 abnormal interfrontal bone morphology http://purl.obolibrary.org/obo/MP_0005274 abnormal viscerocranium morphology any structural anomaly or presence of a bone between the frontal bones in the skull; an extra bony plate within the anterior fontanelle that is not usually present http://purl.obolibrary.org/obo/MP_0008819 abnormal mastication http://purl.obolibrary.org/obo/MP_0001431 abnormal eating behavior any anomaly in the process of biting and mashing food with the teeth prior to swallowing http://purl.obolibrary.org/obo/MP_0008820 abnormal blood uric acid level http://purl.obolibrary.org/obo/MP_0009642 abnormal blood homeostasis aberrant concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine http://purl.obolibrary.org/obo/MP_0008821 increased blood uric acid level http://purl.obolibrary.org/obo/MP_0008820 abnormal blood uric acid level greater concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine http://purl.obolibrary.org/obo/MP_0008822 decreased blood uric acid level http://purl.obolibrary.org/obo/MP_0008820 abnormal blood uric acid level reduced concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine http://purl.obolibrary.org/obo/MP_0008823 abnormal interventricular septum membranous part morphology http://purl.obolibrary.org/obo/MP_0000281 abnormal interventricular septum morphology any structural anomaly of the membranous portion of the wall between the two lower chambers of the heart http://purl.obolibrary.org/obo/MP_0008824 absent interventricular septum membranous part http://purl.obolibrary.org/obo/MP_0008823 abnormal interventricular septum membranous part morphology absence of the membranous portion of the wall between the two lower chambers of the heart http://purl.obolibrary.org/obo/MP_0008825 abnormal cardiac epithelial to mesenchymal transition http://purl.obolibrary.org/obo/MP_0002925 abnormal cardiovascular development anomaly in the process by which endocardial cells of the atrioventricular canal or the outflow tract lose their epithelial characteristics, delaminate from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventually forming both the endocardial cushions required for septum and atrioventricular valve formation and the cushions of the outflow tract that form the conotruncal septum http://purl.obolibrary.org/obo/MP_0008826 abnormal splenic cell ratio http://purl.obolibrary.org/obo/MP_0000689 abnormal spleen morphology deviation from the standard ratios of splenocyte subpopulations compared to control samples http://purl.obolibrary.org/obo/MP_0008827 abnormal thymus cell ratio http://purl.obolibrary.org/obo/MP_0000703 abnormal thymus morphology deviation from the standard ratios of thymocyte subpopulations compared to control samples http://purl.obolibrary.org/obo/MP_0008828 abnormal lymph node cell ratio http://purl.obolibrary.org/obo/MP_0002339 abnormal lymph node morphology deviation from the standard ratios of lymph node cell subpopulations compared to control samples http://purl.obolibrary.org/obo/MP_0008829 triphalangia http://purl.obolibrary.org/obo/MP_0002110 abnormal digit morphology anomaly in which three phalanges are present in the thumb or great toe http://purl.obolibrary.org/obo/MP_0008830 abnormal nucleolus morphology http://purl.obolibrary.org/obo/MP_0003111 abnormal cell nucleus morphology any structural anomaly of the small rounded nuclear substructure that produces ribonucleoprotein http://purl.obolibrary.org/obo/MP_0008831 abnormal insulin-like growth factor I level http://purl.obolibrary.org/obo/MP_0003953 abnormal hormone level anomaly in the concentration of a polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities http://purl.obolibrary.org/obo/MP_0008832 hemivertebra http://purl.obolibrary.org/obo/MP_0000137 abnormal vertebrae morphology a congenital malformation of the spine in which only half of a vertebral body develops http://purl.obolibrary.org/obo/MP_0008833 caudal hemivertebra http://purl.obolibrary.org/obo/MP_0008832 hemivertebra a congenital malformation of the caudal vertebrae in which only half of the vertebral body develops http://purl.obolibrary.org/obo/MP_0008834 abnormal melanosome transport http://purl.obolibrary.org/obo/MP_0001186 pigmentation phenotype any anomaly in the directed movement of melanosomes into, out of, within or between cells http://purl.obolibrary.org/obo/MP_0008835 abnormal intercellular signaling peptide or protein level http://purl.obolibrary.org/obo/MP_0008469 abnormal protein level abnormal concentration of any regulatory protein or peptide that is a signaling molecule involved in the process of paracrine communication http://purl.obolibrary.org/obo/MP_0008836 abnormal transforming growth factor beta level http://purl.obolibrary.org/obo/MP_0008835 abnormal intercellular signaling peptide or protein level abnormal concentration of a paracrine growth factor that has a potential role in embryonic development, cellular differentiation, hormone secretion, and immune function http://purl.obolibrary.org/obo/MP_0008837 increased transforming growth factor level http://purl.obolibrary.org/obo/MP_0008836 abnormal transforming growth factor beta level greater concentration of a paracrine growth factor that has a potential role in embryonic development, cellular differentiation, hormone secretion, and immune function http://purl.obolibrary.org/obo/MP_0008838 decreased transforming growth factor level http://purl.obolibrary.org/obo/MP_0008836 abnormal transforming growth factor beta level reduced concentration of a paracrine growth factor that has a potential role in embryonic development, cellular differentiation, hormone secretion, and immune function http://purl.obolibrary.org/obo/MP_0008839 absent acrosome http://purl.obolibrary.org/obo/MP_0008898 abnormal acrosome morphology mature spermatozoa lack the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration http://purl.obolibrary.org/obo/MP_0008841 ruptured lens capsule http://purl.obolibrary.org/obo/MP_0003236 abnormal lens capsule morphology a break or tear in the elastic, clear, membrane-like structure, that is outer most layer of the lens http://purl.obolibrary.org/obo/MP_0008842 lipofuscinosis http://purl.obolibrary.org/obo/MP_0001186 pigmentation phenotype accumulation of intracellular autofluorescent material, in the form of brownish fatty pigment, in lysosomes as a normal part of senescence or aging http://purl.obolibrary.org/obo/MP_0008843 absent subcutaneous adipose tissue http://purl.obolibrary.org/obo/MP_0011156 abnormal hypodermis fat layer morphology absence of adipose tissue beneath the skin http://purl.obolibrary.org/obo/MP_0008844 decreased subcutaneous adipose tissue amount http://purl.obolibrary.org/obo/MP_0011156 abnormal hypodermis fat layer morphology reduction in amount of adipose tissue beneath the skin http://purl.obolibrary.org/obo/MP_0008845 abnormal paraventricular hypothalamic nucleus morphology http://purl.obolibrary.org/obo/MP_0000837 abnormal hypothalamus morphology any structural anomaly of a group of magnocellular neurons located in the periventricular zone of the anterior half of the hypothalamus http://purl.obolibrary.org/obo/MP_0008846 abnormal supraoptic nucleus morphology http://purl.obolibrary.org/obo/MP_0000837 abnormal hypothalamus morphology any structural anomaly of a group of cells in the hypothalamus located over the lateral border of the optic tract; neurons produce and transport vasopressin http://purl.obolibrary.org/obo/MP_0008847 abnormal suprachiasmatic nucleus morphology http://purl.obolibrary.org/obo/MP_0000837 abnormal hypothalamus morphology any structural anomaly of an ovoid densely packed collection of small cells of the anterior hypothalamus lying close to the midline in a shallow impression of the optic chiasm; it receives input from the retina and influences neuroendocrine function http://purl.obolibrary.org/obo/MP_0008848 abnormal anterior hypothalamic nucleus morphology http://purl.obolibrary.org/obo/MP_0000837 abnormal hypothalamus morphology any structural anomaly of a loose heterogeneous collection of cells in the anterior hypothalamus, continuous rostrally with the medial and lateral preoptic areas and caudally with the tuber cinereum http://purl.obolibrary.org/obo/MP_0008849 abnormal hemoglobin concentration distribution width http://purl.obolibrary.org/obo/MP_0005563 abnormal hemoglobin content anomaly in the standard deviation of the distribution of erythrocytes by their cellular (individual) hemoglobin concentrations http://purl.obolibrary.org/obo/MP_0008850 increased hemoglobin concentration distribution width http://purl.obolibrary.org/obo/MP_0008849 abnormal hemoglobin concentration distribution width higher than normal standard deviation of the distribution of erythrocytes by their cellular (individual) hemoglobin concentrations; high HDW is indicative of some types of anemia/thalassemia http://purl.obolibrary.org/obo/MP_0008851 decreased hemoglobin concentration distribution width http://purl.obolibrary.org/obo/MP_0008849 abnormal hemoglobin concentration distribution width lower than normal standard deviation of the distribution of erythrocytes by their cellular (individual) hemoglobin concentrations http://purl.obolibrary.org/obo/MP_0008852 retinal neovascularization http://purl.obolibrary.org/obo/MP_0003711 pathological neovascularization formation of new blood vessels originating from the retinal veins and extending along the inner (vitreal) surface of the retina http://purl.obolibrary.org/obo/MP_0008853 decreased abdominal adipose tissue amount http://purl.obolibrary.org/obo/MP_0001781 abnormal white adipose tissue amount reduction in amount of adipose tissue associated with internal organs http://purl.obolibrary.org/obo/MP_0008854 bleb http://purl.obolibrary.org/obo/MP_0009931 abnormal skin appearance presence of a blister-like, nearly hemispherical structure filled with air, serous fluid or blood http://purl.obolibrary.org/obo/MP_0008855 eye bleb http://purl.obolibrary.org/obo/MP_0001286 abnormal eye development presence of blister-like structures formed in the eye during embryonic development that are usually filled with blood http://purl.obolibrary.org/obo/MP_0008856 fetal bleb http://purl.obolibrary.org/obo/MP_0003941 abnormal skin development presence of subepidermal blister-like structures on the skin, often on the head, formed during embryonic development and usually filled with blood http://purl.obolibrary.org/obo/MP_0008857 myelencephalic blebs http://purl.obolibrary.org/obo/MP_0006108 abnormal hindbrain development presence of blister-like structures formed on the posterior portion of the embryonic hindbrain that are usually filled with blood http://purl.obolibrary.org/obo/MP_0008858 abnormal hair cycle anagen phase http://purl.obolibrary.org/obo/MP_0000427 abnormal hair cycle anomaly in the growth phase of the hair cycle http://purl.obolibrary.org/obo/MP_0008859 abnormal hair cycle catagen phase http://purl.obolibrary.org/obo/MP_0000427 abnormal hair cycle anomaly in the phase of the hair growth cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored hair is produced http://purl.obolibrary.org/obo/MP_0008860 abnormal hair cycle telogen phase http://purl.obolibrary.org/obo/MP_0000427 abnormal hair cycle anomaly in the resting or quiescent phase of the hair growth cycle which follows cessation of proliferation (catagen) and precedes hair loss http://purl.obolibrary.org/obo/MP_0008861 abnormal hair shedding http://purl.obolibrary.org/obo/MP_0000427 abnormal hair cycle anomaly in the hair cycle changes the timing of the hair loss that normally follows the anagen phase http://purl.obolibrary.org/obo/MP_0008862 asymmetric snout http://purl.obolibrary.org/obo/MP_0000443 abnormal snout morphology presence of a snout that lacks mirrored identity on either side of the median plane http://purl.obolibrary.org/obo/MP_0008863 craniofacial asymmetry http://purl.obolibrary.org/obo/MP_0003935 abnormal craniofacial development head or facial features that lack mirrored identity on either side of the median plane http://purl.obolibrary.org/obo/MP_0008864 abnormal intestinal secretion http://purl.obolibrary.org/obo/MP_0000501 abnormal digestive secretion any anomaly in the quantity or rate of any substance transported from intestinal cells into the lumen of the intestine http://purl.obolibrary.org/obo/MP_0008867 uniparental disomy http://purl.obolibrary.org/obo/MP_0001930 abnormal meiosis abnormal assortment of chromosomes from parent to offspring whereby the chromosome number is correct, but both members of a chromosome pair or segments of a chromosome pair are inherited from the same parent http://purl.obolibrary.org/obo/MP_0008869 anovulation http://purl.obolibrary.org/obo/MP_0001928 abnormal ovulation complete failure of ovum to be released from an ovarian follicle http://purl.obolibrary.org/obo/MP_0008870 increased mature ovarian follicle number http://purl.obolibrary.org/obo/MP_0009364 abnormal mature ovarian follicle morphology than normal numbers of ovarian follicles that are ready for ovulation and present a blanched spot (the follicular stigma) where the graafian follicle is about to rupture on the surface of the ovary; a first maturation (meiotic) division of the primary oocyte usually occurs just prior to rupture of the follicle http://purl.obolibrary.org/obo/MP_0008872 abnormal physiological response to xenobiotic http://purl.obolibrary.org/obo/MP_0005376 homeostasis/metabolism phenotype any anomaly in the physiological or morphological changes induced by a foreign compound, such as changes in blood pressure, changes in hormone or protein levels or hypertrophy or hypotrophy of an organ http://purl.obolibrary.org/obo/MP_0008873 increased physiological sensitivity to xenobiotic http://purl.obolibrary.org/obo/MP_0008872 abnormal physiological response to xenobiotic decrease in the dose or concentration of a foreign compound required to induce a specific level of physiological response http://purl.obolibrary.org/obo/MP_0008874 decreased physiological sensitivity to xenobiotic http://purl.obolibrary.org/obo/MP_0008872 abnormal physiological response to xenobiotic increase in the dose or concentration of a foreign compound required to induce a specific level of physiological response http://purl.obolibrary.org/obo/MP_0008875 abnormal xenobiotic pharmacokinetics http://purl.obolibrary.org/obo/MP_0005266 abnormal metabolism any anomaly in the absorption, distribution, metabolism or elimination of a foreign compound http://purl.obolibrary.org/obo/MP_0008876 decreased uterine NK cell number http://purl.obolibrary.org/obo/MP_0008054 abnormal uterine NK cell morphology reduced cell number of a natural killer cell subset that is found in the decidual of the uterus, is CD56-high, Galectin-1-positive and CD16-negative, and is the most abundant immune cell type in the decidual during the first trimester of pregnancy http://purl.obolibrary.org/obo/MP_0008877 abnormal DNA methylation http://purl.obolibrary.org/obo/MP_0012167 abnormal epigenetic regulation of gene expression any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA http://purl.obolibrary.org/obo/MP_0008878 abnormal DNA methylation during gametogenesis http://purl.obolibrary.org/obo/MP_0008877 abnormal DNA methylation any anomaly of the covalent transfer of a methyl group to C-5 of cytosine during gamete generation, when DNA methylation patterns are established http://purl.obolibrary.org/obo/MP_0008879 submandibular gland inflammation http://purl.obolibrary.org/obo/MP_0001870 salivary gland inflammation local accumulation of fluid, plasma proteins, and leukocytes in either of the large major salivary glands situated beneath the mandible http://purl.obolibrary.org/obo/MP_0008880 lacrimal gland inflammation http://purl.obolibrary.org/obo/MP_0001846 increased inflammatory response local accumulation of fluid, plasma proteins, and leukocytes in the glands that secrete tears http://purl.obolibrary.org/obo/MP_0008881 absent Harderian gland http://purl.obolibrary.org/obo/MP_0005248 abnormal Harderian gland morphology absence of the sebaceous gland located behind the eyeball that excretes fluid that facilitates movement of the nictitating membrane http://purl.obolibrary.org/obo/MP_0008882 abnormal enterocyte physiology http://purl.obolibrary.org/obo/MP_0010155 abnormal intestine physiology any functional anomaly of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen http://purl.obolibrary.org/obo/MP_0008883 abnormal enterocyte proliferation http://purl.obolibrary.org/obo/MP_0008882 abnormal enterocyte physiology anomaly in the ability of the enterocyte cell population to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0008884 abnormal enterocyte apoptosis http://purl.obolibrary.org/obo/MP_0008882 abnormal enterocyte physiology change in the timing or the number of enterocytes undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0008885 increased enterocyte apoptosis http://purl.obolibrary.org/obo/MP_0008884 abnormal enterocyte apoptosis increase in the timing or the number of enterocytes undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0008886 abnormal PML bodies http://purl.obolibrary.org/obo/MP_0003111 abnormal cell nucleus morphology alteration in structure, number or location of the subnuclear structures associated with functions including transcription, DNA repair, viral defense, stress, cell cycle regulation, proteolysis and apoptosis http://purl.obolibrary.org/obo/MP_0008887 abnormal splicing factor domain morphology http://purl.obolibrary.org/obo/MP_0003111 abnormal cell nucleus morphology alteration in structure, number or location of subnuclear structures comprising storage locations for elements responsible for excising non-coding regions from a primary messenger RNA transcript and joining coding regions to produce mature messenger RNA http://purl.obolibrary.org/obo/MP_0008888 abnormal Cajal body morphology http://purl.obolibrary.org/obo/MP_0003111 abnormal cell nucleus morphology alteration in structure, number or location of subnuclear structures involved in snRNP biogenesis and in the trafficking of snoRNPs and snRNPs http://purl.obolibrary.org/obo/MP_0008889 abnormal Gem morphology http://purl.obolibrary.org/obo/MP_0003111 abnormal cell nucleus morphology alteration in structure, number or location of subnuclear structures involved in snRNP biogenesis and in the trafficking of snoRNPs and snRNPs and found paired with or juxtaposed to Cajal bodies http://purl.obolibrary.org/obo/MP_0008890 abnormal nuclear lamina morphology http://purl.obolibrary.org/obo/MP_0003111 abnormal cell nucleus morphology any structural anomaly of the inner nuclear membrane surrounding the nuclear periphery, comprising a scaffold-like network of protein filaments responsible for trafficking of mRNA to the cytoplasm http://purl.obolibrary.org/obo/MP_0008891 decreased hepatocyte apoptosis http://purl.obolibrary.org/obo/MP_0010080 abnormal hepatocyte physiology reduction in the number of hepatocytes undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0008892 abnormal sperm flagellum morphology http://purl.obolibrary.org/obo/MP_0013206 abnormal motile cilium morphology any structural anomaly of the whiplike posterior filiform portion of the spermatozoon composed of a number of cytoskeletal elements whose proper assembly is critical for sperm motility; the mammalian flagellum is structurally divided into four major parts: the connecting piece, the midpiece, the principal piece, and the end piece http://purl.obolibrary.org/obo/MP_0008893 detached sperm flagellum http://purl.obolibrary.org/obo/MP_0008892 abnormal sperm flagellum morphology fragmentation of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility from the sperm head http://purl.obolibrary.org/obo/MP_0008894 abnormal intraepithelial T cell morphology http://purl.obolibrary.org/obo/MP_0008037 abnormal T cell morphology any structural anomaly of a T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements http://purl.obolibrary.org/obo/MP_0008895 abnormal intraepithelial T cell number http://purl.obolibrary.org/obo/MP_0008894 abnormal intraepithelial T cell morphology reduced number of T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements http://purl.obolibrary.org/obo/MP_0008896 increased IgG2c level http://purl.obolibrary.org/obo/MP_0020178 abnormal IgG2c level greater than normal immunoglobulin class G2c level http://purl.obolibrary.org/obo/MP_0008897 decreased IgG2c level http://purl.obolibrary.org/obo/MP_0020178 abnormal IgG2c level less than normal immunoglobulin class G2c level http://purl.obolibrary.org/obo/MP_0008899 plush coat http://purl.obolibrary.org/obo/MP_0001510 abnormal coat appearance coat has a thick, velvet-like appearance http://purl.obolibrary.org/obo/MP_0008900 abnormal uterine fat pad morphology http://purl.obolibrary.org/obo/MP_0000010 abnormal abdominal fat pad morphology any structural anomaly of the encapsulated adipose tissue associated with the uterus http://purl.obolibrary.org/obo/MP_0008901 absent epididymal fat pad http://purl.obolibrary.org/obo/MP_0006319 abnormal epididymal fat pad morphology absence of the encapsulated adipose tissue associated with the epididymis http://purl.obolibrary.org/obo/MP_0008902 abnormal renal fat pad morphology http://purl.obolibrary.org/obo/MP_0005334 abnormal fat pad morphology any structural anomaly of the encapsulated adipose tissue associated with the kidney http://purl.obolibrary.org/obo/MP_0008903 abnormal mesenteric fat pad morphology http://purl.obolibrary.org/obo/MP_0000010 abnormal abdominal fat pad morphology any structural anomaly of the encapsulated adipose tissue associated with the mesentery http://purl.obolibrary.org/obo/MP_0008904 abnormal mammary fat pad morphology http://purl.obolibrary.org/obo/MP_0005334 abnormal fat pad morphology any structural anomaly of the encapsulated adipose tissue associated with the mammary gland http://purl.obolibrary.org/obo/MP_0008905 abnormal femoral fat pad morphology http://purl.obolibrary.org/obo/MP_0005334 abnormal fat pad morphology any structural anomaly of the encapsulated adipose tissue associated with the femur http://purl.obolibrary.org/obo/MP_0008906 abnormal parametrial fat pad morphology http://purl.obolibrary.org/obo/MP_0000010 abnormal abdominal fat pad morphology any structural anomaly of the encapsulated adipose tissue associated with the extension of the subserous coat of the uterus laterally between the layers of the broad ligament http://purl.obolibrary.org/obo/MP_0008907 decreased total fat pad weight http://purl.obolibrary.org/obo/MP_0020130 abnormal total fat pad weight less than average weight of the fat pads http://purl.obolibrary.org/obo/MP_0008908 increased total fat pad weight http://purl.obolibrary.org/obo/MP_0020130 abnormal total fat pad weight greater than average weight of the fat pads http://purl.obolibrary.org/obo/MP_0008909 supination http://purl.obolibrary.org/obo/MP_0000572 abnormal autopod morphology rotation of the pedal or prehensile extremity so the forefoot (hand) faces anteriorly to the anatomic position; rotation of the hindfoot (foot) such that the plantar surface turns upward http://purl.obolibrary.org/obo/MP_0008910 thin long bone epiphysis http://purl.obolibrary.org/obo/MP_0000131 abnormal long bone epiphysis morphology thinner than normal rounded end of a long bone http://purl.obolibrary.org/obo/MP_0008912 nervous http://purl.obolibrary.org/obo/MP_0008911 induced hyperactivity increased, skittish, behavior induced by stimulation such as handling, touching or noise http://purl.obolibrary.org/obo/MP_0008913 weaving http://purl.obolibrary.org/obo/MP_0003312 abnormal locomotor coordination momentary, slow motions of the whole body from side to side sometimes followed by a sudden drop from an erect position http://purl.obolibrary.org/obo/MP_0008914 enlarged cerebellum http://purl.obolibrary.org/obo/MP_0000849 abnormal cerebellum morphology increased size of the cerebellum http://purl.obolibrary.org/obo/MP_0008915 fused carpal bones http://purl.obolibrary.org/obo/MP_0000554 abnormal carpal bone morphology anomaly of the nine nodular bones of the joint between the forelimb bones and the front paws/hands resulting in some or all the bones being joined together http://purl.obolibrary.org/obo/MP_0008916 abnormal astrocyte physiology http://purl.obolibrary.org/obo/MP_0003690 abnormal glial cell physiology any functional anomaly of one of the large neuroglia cells of nervous tissue http://purl.obolibrary.org/obo/MP_0008917 abnormal oligodendrocyte physiology http://purl.obolibrary.org/obo/MP_0003690 abnormal glial cell physiology any functional anomaly of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS http://purl.obolibrary.org/obo/MP_0008918 microgliosis http://purl.obolibrary.org/obo/MP_0002183 gliosis a proliferation or spread of microglia in the area of a degenerative lesion or damaged tissue http://purl.obolibrary.org/obo/MP_0008919 fused tarsal bones http://purl.obolibrary.org/obo/MP_0005104 abnormal tarsal bone morphology anomaly of the eight bones of the instep of the paw/foot resulting in some or all the bones being joined together http://purl.obolibrary.org/obo/MP_0008920 absent cervical axis http://purl.obolibrary.org/obo/MP_0004608 abnormal cervical axis morphology absence of the second cervical vertebra (C2) which forms the pivot upon which the first cervical (atlas, C1) vertebra rotates http://purl.obolibrary.org/obo/MP_0008921 increased neurotransmitter release http://purl.obolibrary.org/obo/MP_0005445 abnormal neurotransmitter secretion increased production or release of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells http://purl.obolibrary.org/obo/MP_0008922 abnormal cervical rib http://purl.obolibrary.org/obo/MP_0000150 abnormal rib morphology alternate location or appearance of a rare supernumerary rib commonly articulating with the seventh cervical vertebrae (above the normal first rib) but not reaching the sternum anteriorly http://purl.obolibrary.org/obo/MP_0008923 thoracoschisis http://purl.obolibrary.org/obo/MP_0003385 abnormal body wall morphology congenital fissure of the chest wall http://purl.obolibrary.org/obo/MP_0008924 decreased cerebellar granule cell number http://purl.obolibrary.org/obo/MP_0008948 decreased neuron number reduction in the number of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites http://purl.obolibrary.org/obo/MP_0008925 increased cerebellar granule cell number http://purl.obolibrary.org/obo/MP_0008947 increased neuron number greater number of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites http://purl.obolibrary.org/obo/MP_0008926 abnormal anterior definitive endoderm morphology http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology any structural anomaly of the mesendoderm which first migrates from the node and evolves into the foregut, from which pancreas, liver and lungs will eventually emerge http://purl.obolibrary.org/obo/MP_0008928 abnormal paracentral nucleus morphology http://purl.obolibrary.org/obo/MP_0000832 abnormal thalamus morphology any structural anomaly of one of the intralaminar nuclei of the thalamus, located medial to the central lateral nucleus http://purl.obolibrary.org/obo/MP_0008929 abnormal central medial nucleus morphology http://purl.obolibrary.org/obo/MP_0000832 abnormal thalamus morphology any structural anomaly of a small cell group in the interthalamic adhesion of the thalamus that occupy the midline region of the internal medullary lamina, between the left and right paracentral nuclei http://purl.obolibrary.org/obo/MP_0008930 abnormal medial geniculate nucleus morphology http://purl.obolibrary.org/obo/MP_0000832 abnormal thalamus morphology any structural anomaly of groups of nerve cells that function as a relay of auditory input to auditory cortex, receiving the brachium of the inferior colliculus and sending processed information to the auditory cortex in the superior temporal gyrus http://purl.obolibrary.org/obo/MP_0008932 abnormal embryonic tissue physiology http://purl.obolibrary.org/obo/MP_0001672 abnormal embryogenesis/ development any functional anomaly in any of the tissues of the embryo proper http://purl.obolibrary.org/obo/MP_0008933 abnormal motile primary cilium physiology http://purl.obolibrary.org/obo/MP_0013210 abnormal primary cilium physiology any functional anomaly of the cilia of the mouse embryo found on the cells of the embryonic node, which generate flow of extraembryonic fluid surrounding the node in a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization http://purl.obolibrary.org/obo/MP_0008934 absent choroid plexus http://purl.obolibrary.org/obo/MP_0000820 abnormal choroid plexus morphology absence of the infoldings of blood vessels of the pia mater covered by a thin coat of ependymal cells that form tufted projections into the third, fourth, and lateral ventricles of the brain http://purl.obolibrary.org/obo/MP_0008935 decreased mean platelet volume http://purl.obolibrary.org/obo/MP_0002586 abnormal platelet volume reduced average content of platelet cells over normal http://purl.obolibrary.org/obo/MP_0008937 abnormal pituitary gland weight http://purl.obolibrary.org/obo/MP_0008936 abnormal pituitary gland size anomaly in the average weight of the compound gland suspended from the base of the hypothalamus http://purl.obolibrary.org/obo/MP_0008938 decreased pituitary gland weight http://purl.obolibrary.org/obo/MP_0008937 abnormal pituitary gland weight reduction in the average weight of the compound gland suspended from the base of the hypothalamus http://purl.obolibrary.org/obo/MP_0008939 increased pituitary gland weight http://purl.obolibrary.org/obo/MP_0008937 abnormal pituitary gland weight greater than average weight of the compound gland suspended from the base of the hypothalamus http://purl.obolibrary.org/obo/MP_0008940 delayed balanopreputial separation http://purl.obolibrary.org/obo/MP_0001938 delayed sexual maturation the separation of the prepuce from the glans penis (balanus), a result of the cornification of the balano-preputial epithelium, occurring at a later than expected age; balanopreputial separation is used as an index for the onset of male puberty and is androgen-sensitive in the rat http://purl.obolibrary.org/obo/MP_0008941 reticulocytopenia http://purl.obolibrary.org/obo/MP_0011913 abnormal reticulocyte cell number decrease in the normal number of circulating reticulocytes http://purl.obolibrary.org/obo/MP_0008942 abnormal induced cell death http://purl.obolibrary.org/obo/MP_0000313 abnormal cell death anomaly in the response to an agent that induces cessation of function at the cellular level http://purl.obolibrary.org/obo/MP_0008945 hyperchromic macrocytic anemia http://purl.obolibrary.org/obo/MP_0002811 macrocytic anemia deficiency of red blood cells in which the remaining circulating erythrocyte corpuscular volume is larger than normal and the total amount of hemoglobin per cell is increased, but the percentage of hemoglobin per cell is usually in the normochromic range http://purl.obolibrary.org/obo/MP_0008946 abnormal neuron number http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology anomaly in the number of the cells of the nervous system that receive, conduct, and transmit impulses http://purl.obolibrary.org/obo/MP_0008949 increased Cajal-Retzius cell number http://purl.obolibrary.org/obo/MP_0008030 abnormal Cajal-Retzius cell morphology greater number of the distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus http://purl.obolibrary.org/obo/MP_0008950 ventricular tachycardia http://purl.obolibrary.org/obo/MP_0002626 increased heart rate paroxysmal rapid beating of the heart originating in an ectopic focus in the heart ventricle http://purl.obolibrary.org/obo/MP_0008951 long radius http://purl.obolibrary.org/obo/MP_0004695 increased length of long bones increased length of the short bone of the lateral forearm http://purl.obolibrary.org/obo/MP_0008952 abnormal pancreatic delta cell physiology http://purl.obolibrary.org/obo/MP_0010147 abnormal endocrine pancreas physiology any functional anomaly of the cells found in the pancreas that secrete somatostatin http://purl.obolibrary.org/obo/MP_0008953 abnormal pancreatic somatostatin secretion http://purl.obolibrary.org/obo/MP_0008952 abnormal pancreatic delta cell physiology anomaly in the production or release from pancreatic delta cells of a 14 amino acid peptide that inhibits growth hormone release and is found in the central and peripheral nervous systems, the gut, and other organs http://purl.obolibrary.org/obo/MP_0008954 abnormal cellular hemoglobin content http://purl.obolibrary.org/obo/MP_0005563 abnormal hemoglobin content anomaly in the mean of the red blood cell hemoglobin concentration (RBC CH) histogram, which represents the distribution of red blood cells by the amount of hemoglobin present in each individual cell independent of cell volume http://purl.obolibrary.org/obo/MP_0008955 increased cellular hemoglobin content http://purl.obolibrary.org/obo/MP_0008954 abnormal cellular hemoglobin content increase in the mean of the red blood cell hemoglobin concentration (RBC CH) histogram, which represents the distribution of red blood cells by the amount of hemoglobin present in each individual cell independent of cell volume http://purl.obolibrary.org/obo/MP_0008956 decreased cellular hemoglobin content http://purl.obolibrary.org/obo/MP_0008954 abnormal cellular hemoglobin content decrease in the mean of the red blood cell hemoglobin concentration (RBC CH) histogram, which represents the distribution of red blood cells by the amount of hemoglobin present in each individual cell independent of cell volume http://purl.obolibrary.org/obo/MP_0008958 abnormal trophoblast glycogen cell morphology http://purl.obolibrary.org/obo/MP_0004255 abnormal spongiotrophoblast layer morphology any structural anomaly of a glycogen-accumulating trophoblast cell that arises in the junctional zone of the placenta http://purl.obolibrary.org/obo/MP_0008959 abnormal spongiotrophoblast cell morphology http://purl.obolibrary.org/obo/MP_0004255 abnormal spongiotrophoblast layer morphology any structural anomaly of a trophoblast cell that arises in the junctional zone of the placenta http://purl.obolibrary.org/obo/MP_0008960 abnormal axon pruning http://purl.obolibrary.org/obo/MP_0009937 abnormal neuron differentiation defects in the developmental elimination of axons that fail to participate in an active neuronal circuit by retraction, degeneration, shedding or other mechanism http://purl.obolibrary.org/obo/MP_0008961 abnormal basal metabolism http://purl.obolibrary.org/obo/MP_0005266 abnormal metabolism any anomaly in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state http://purl.obolibrary.org/obo/MP_0008962 abnormal carbon dioxide production http://purl.obolibrary.org/obo/MP_0003948 abnormal gas homeostasis deviation from the normal rate at which carbon dioxide leaves the blood and enters the alveolar gas http://purl.obolibrary.org/obo/MP_0008963 increased carbon dioxide production http://purl.obolibrary.org/obo/MP_0008962 abnormal carbon dioxide production increase in the rate at which carbon dioxide leaves the blood and enters the alveolar gas http://purl.obolibrary.org/obo/MP_0008964 decreased carbon dioxide production http://purl.obolibrary.org/obo/MP_0008962 abnormal carbon dioxide production reduction in the rate at which carbon dioxide leaves the blood and enters the alveolar gas http://purl.obolibrary.org/obo/MP_0008965 increased basal metabolism http://purl.obolibrary.org/obo/MP_0008961 abnormal basal metabolism increase in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state http://purl.obolibrary.org/obo/MP_0008966 abnormal chiasmata formation http://purl.obolibrary.org/obo/MP_0001930 abnormal meiosis atypical contact between nonsister chromatids of homologous chromosomes during meiosis I, precluding formation of the expected number of cross-shaped configurations representing recombination events http://purl.obolibrary.org/obo/MP_0008967 absent chiasmata formation http://purl.obolibrary.org/obo/MP_0008966 abnormal chiasmata formation during meiosis I there are no observable cross-over regions where nonsister chromatids of homologous chromosomes recombine with each other http://purl.obolibrary.org/obo/MP_0008969 abnormal nasolacrimal duct morphology http://purl.obolibrary.org/obo/MP_0008968 abnormal lacrimal apparatus morphology any structural anomaly of the paired channels leading from the lacrimal sacs to the inferior meatus of the nose, through which tears are conducted through the nasal cavity http://purl.obolibrary.org/obo/MP_0008970 choanal atresia http://purl.obolibrary.org/obo/MP_0002236 abnormal internal nares morphology blockage of the back of the nasal passage by abnormal bony or soft tissue, usually due to failure of the bucconasal membrane to involute during development http://purl.obolibrary.org/obo/MP_0008971 abnormal ethmoturbinate morphology http://purl.obolibrary.org/obo/MP_0002244 abnormal turbinate morphology any structural anomaly of the conchae of the ethmoid bone which occupy the caudal part of the nasal fossae and form the lateral and superior portions of the turbinate bones in mammals http://purl.obolibrary.org/obo/MP_0008972 ethmoturbinate hypoplasia http://purl.obolibrary.org/obo/MP_0008971 abnormal ethmoturbinate morphology underdevelopment or reduced size, usually due to a reduced number of cells, of the conchae of the ethmoid bone which occupy the caudal part of the nasal fossae and form the lateral and superior portions of the turbinate bones in mammals http://purl.obolibrary.org/obo/MP_0008974 proportional dwarf http://purl.obolibrary.org/obo/MP_0001265 decreased body size abnormally undersized with both limbs and trunk symmetrically shorter; usually due to chemical, endocrine, nutritional or nonosseous influences http://purl.obolibrary.org/obo/MP_0008975 delayed male fertility http://purl.obolibrary.org/obo/MP_0002683 delayed fertility ability of a male organism to produce live offspring occurring at a later than expected age http://purl.obolibrary.org/obo/MP_0008976 delayed female fertility http://purl.obolibrary.org/obo/MP_0002683 delayed fertility ability of a female organism to produce live offspring occurring at a later than expected age http://purl.obolibrary.org/obo/MP_0008977 abnormal vagina size http://purl.obolibrary.org/obo/MP_0001139 abnormal vagina morphology anomaly in the size of the female reproductive canal located between the uterus and the vulva http://purl.obolibrary.org/obo/MP_0008978 abnormal vagina weight http://purl.obolibrary.org/obo/MP_0008977 abnormal vagina size anomaly in the weight of the female reproductive canal located between the uterus and the vulva http://purl.obolibrary.org/obo/MP_0008979 increased vagina weight http://purl.obolibrary.org/obo/MP_0008981 enlarged vagina increase in the weight of the female reproductive canal located between the uterus and the vulva http://purl.obolibrary.org/obo/MP_0008980 decreased vagina weight http://purl.obolibrary.org/obo/MP_0008983 small vagina decrease in the weight of the female reproductive canal located between the uterus and the vulva http://purl.obolibrary.org/obo/MP_0008981 enlarged vagina http://purl.obolibrary.org/obo/MP_0008977 abnormal vagina size increase in the size of the female reproductive canal located between the uterus and the vulva http://purl.obolibrary.org/obo/MP_0008982 vagina hyperplasia http://purl.obolibrary.org/obo/MP_0008981 enlarged vagina overdevelopment or increased size of the vagina, usually due an increased number of cells http://purl.obolibrary.org/obo/MP_0008983 small vagina http://purl.obolibrary.org/obo/MP_0008977 abnormal vagina size decrease in the size of the female reproductive canal located between the uterus and the vulva http://purl.obolibrary.org/obo/MP_0008984 vagina hypoplasia http://purl.obolibrary.org/obo/MP_0008983 small vagina underdevelopment or reduced size of the vagina, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0008985 hemimelia http://purl.obolibrary.org/obo/MP_0002109 abnormal limb morphology congenital absence of part of an extremity, such as absent fibula with the tibia present http://purl.obolibrary.org/obo/MP_0008986 abnormal liver parenchyma morphology http://purl.obolibrary.org/obo/MP_0000598 abnormal liver morphology any structural anomaly of the functional units of the liver including the lobules http://purl.obolibrary.org/obo/MP_0008988 abnormal liver perisinusoidal space morphology http://purl.obolibrary.org/obo/MP_0008987 abnormal liver lobule morphology any structural anomaly of the extravascular space in the liver between the parenchymal cells and a sinusoid that contains the blood plasma http://purl.obolibrary.org/obo/MP_0008990 abnormal Ito cell morphology http://purl.obolibrary.org/obo/MP_0008988 abnormal liver perisinusoidal space morphology any structural anomaly of the fat-storing cells that line the hepatic sinusoids http://purl.obolibrary.org/obo/MP_0008991 abnormal bile canaliculus morphology http://purl.obolibrary.org/obo/MP_0008987 abnormal liver lobule morphology any structural anomaly of the intercellular channels that take up bile from hepatocytes and transport it to the bile ducts http://purl.obolibrary.org/obo/MP_0008992 abnormal portal lobule morphology http://purl.obolibrary.org/obo/MP_0008986 abnormal liver parenchyma morphology any structural anomaly of the triangular region on the periphery of the liver lobules that contain a bile duct and a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel http://purl.obolibrary.org/obo/MP_0008993 abnormal portal triad morphology http://purl.obolibrary.org/obo/MP_0008992 abnormal portal lobule morphology any structural anomaly of the three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel http://purl.obolibrary.org/obo/MP_0008994 early vaginal opening http://purl.obolibrary.org/obo/MP_0020150 abnormal timing of vaginal opening the opening of the genital canal in a female occurring at an earlier than expected age http://purl.obolibrary.org/obo/MP_0008995 early reproductive senescence http://purl.obolibrary.org/obo/MP_0003786 premature aging loss of reproductive capacity occurring at an earlier than expected age http://purl.obolibrary.org/obo/MP_0008996 abnormal blood osmolality http://purl.obolibrary.org/obo/MP_0009642 abnormal blood homeostasis anomaly in the concentration of ions in the blood or blood fractions compared to the normal state, sometimes reported as increased or decreased osmotic fragility http://purl.obolibrary.org/obo/MP_0008997 increased blood osmolality http://purl.obolibrary.org/obo/MP_0008996 abnormal blood osmolality increase in the concentration of ions in the blood compared to the normal state http://purl.obolibrary.org/obo/MP_0008998 decreased blood osmolality http://purl.obolibrary.org/obo/MP_0008996 abnormal blood osmolality decrease in the concentration of ions in the blood compared to the normal state http://purl.obolibrary.org/obo/MP_0008999 absent anus http://purl.obolibrary.org/obo/MP_0005034 abnormal anus morphology absence of the lower opening of the digestive tract http://purl.obolibrary.org/obo/MP_0009000 absent cecum http://purl.obolibrary.org/obo/MP_0000494 abnormal cecum morphology absence of the large sac at the ileum and large intestine junction http://purl.obolibrary.org/obo/MP_0009001 absent hallux http://purl.obolibrary.org/obo/MP_0009049 abnormal hallux morphology absence of the first or primary digit of the foot http://purl.obolibrary.org/obo/MP_0009002 premature hair regrowth http://purl.obolibrary.org/obo/MP_0002073 abnormal hair growth faster initiation of the hair growth cycle (anagen) after catagen phase http://purl.obolibrary.org/obo/MP_0009003 abnormal vibrissa number http://purl.obolibrary.org/obo/MP_0002098 abnormal vibrissa morphology any anomaly in the number of the stiff hairs projecting from the face around the nose of most mammals which act as touch receptors http://purl.obolibrary.org/obo/MP_0009004 progressive hair loss http://purl.obolibrary.org/obo/MP_0002073 abnormal hair growth thinning of hair (coat) over time, usually in a defined pattern, until entirely gone with no recurrent growth http://purl.obolibrary.org/obo/MP_0009005 abnormal sesamoid bone of gastrocnemius morphology http://purl.obolibrary.org/obo/MP_0002115 abnormal limb bone morphology any structural anomaly of the small sesamoid bones situated behind the condyles of the femur http://purl.obolibrary.org/obo/MP_0009006 prolonged estrous cycle http://purl.obolibrary.org/obo/MP_0001927 abnormal estrous cycle increase in the length of the estrous cycle http://purl.obolibrary.org/obo/MP_0009007 short estrous cycle http://purl.obolibrary.org/obo/MP_0001927 abnormal estrous cycle decrease in the length of the estrous cycle http://purl.obolibrary.org/obo/MP_0009008 delayed estrous cycle http://purl.obolibrary.org/obo/MP_0001927 abnormal estrous cycle onset of the estrous cycle of females occurring at a later than expected day/age http://purl.obolibrary.org/obo/MP_0009009 absent estrous cycle http://purl.obolibrary.org/obo/MP_0001927 abnormal estrous cycle failure of female animals to enter or progress through the estrous cycle http://purl.obolibrary.org/obo/MP_0009010 abnormal diestrus http://purl.obolibrary.org/obo/MP_0001927 abnormal estrous cycle any anomaly or aberrant timing of the last phase of the estrous cycle, during which unfertilized eggs are eliminated, the vagina and vulva are at a minimum size, and new follicles begin to undergo a rapid growth for the next ovulation; if pregnancy does not occur, the metestrous phase is ultimately followed by the diestrous phase http://purl.obolibrary.org/obo/MP_0009011 prolonged diestrus http://purl.obolibrary.org/obo/MP_0009010 abnormal diestrus increase in the length of the diestrous phase of the estrous cycle in female animals http://purl.obolibrary.org/obo/MP_0009012 short diestrus http://purl.obolibrary.org/obo/MP_0009010 abnormal diestrus decrease in the length of the diestrous phase of the estrous cycle in female animals http://purl.obolibrary.org/obo/MP_0009013 abnormal proestrus http://purl.obolibrary.org/obo/MP_0001927 abnormal estrous cycle any anomaly or aberrant timing of the first phase of the estrous cycle which begins when a new batch of eggs reach maturity within ovarian follicles that are ripe and large; external examination of the female usually shows a bloated vulva with an open vagina http://purl.obolibrary.org/obo/MP_0009014 prolonged proestrus http://purl.obolibrary.org/obo/MP_0009013 abnormal proestrus increase in the length of the proestrous phase of the estrous cycle in female animals http://purl.obolibrary.org/obo/MP_0009015 short proestrus http://purl.obolibrary.org/obo/MP_0009013 abnormal proestrus decrease in the length of the proestrous phase of the estrous cycle in female animals http://purl.obolibrary.org/obo/MP_0009016 abnormal estrus http://purl.obolibrary.org/obo/MP_0001927 abnormal estrous cycle any anomaly or aberrant timing of the phase of the estrous cycle which begins with the ovulation of fully mature oocytes and during which the vulva remains in an extended state with an open vagina, and females are maximally receptive to male advances http://purl.obolibrary.org/obo/MP_0009017 prolonged estrus http://purl.obolibrary.org/obo/MP_0009016 abnormal estrus increase in the length of the estrous phase of the estrous cycle in female animals http://purl.obolibrary.org/obo/MP_0009018 short estrus http://purl.obolibrary.org/obo/MP_0009016 abnormal estrus decrease in the length of the estrous phase of the estrous cycle in female animals http://purl.obolibrary.org/obo/MP_0009019 abnormal metestrus http://purl.obolibrary.org/obo/MP_0001927 abnormal estrous cycle any anomaly or aberrant timing of the phase of the estrous cycle which follows estrus when mature eggs move through the oviducts and into the uterus; the vulva is no longer bloated, and the vagina is now closed http://purl.obolibrary.org/obo/MP_0009020 prolonged metestrus http://purl.obolibrary.org/obo/MP_0009019 abnormal metestrus increase in the length of the metestrous phase of the estrous cycle in female animals http://purl.obolibrary.org/obo/MP_0009021 absent estrus http://purl.obolibrary.org/obo/MP_0009016 abnormal estrus absence or failure of the estrous phase of the estrous cycle in female animals http://purl.obolibrary.org/obo/MP_0009022 abnormal brain meninges morphology http://purl.obolibrary.org/obo/MP_0005623 abnormal meninges morphology any structural anomaly in any of the membranes covering the brain, including the dura mater (external), arachnoid (middle), and pia mater (internal) http://purl.obolibrary.org/obo/MP_0009023 abnormal spinal cord meninges morphology http://purl.obolibrary.org/obo/MP_0005623 abnormal meninges morphology any structural anomaly in any of the membranes covering the spinal cord, including the dura mater (external), arachnoid (middle), and pia mater (internal) http://purl.obolibrary.org/obo/MP_0009024 abnormal brain arachnoid mater morphology http://purl.obolibrary.org/obo/MP_0009022 abnormal brain meninges morphology any structural anomaly of the fibrous membrane forming the middle of the three coverings that surrounds the brain within the cranial cavity http://purl.obolibrary.org/obo/MP_0009025 abnormal brain dura mater morphology http://purl.obolibrary.org/obo/MP_0009022 abnormal brain meninges morphology any structural anomaly of the fibrous membrane forming the outer of the three coverings that surrounds the brain within the cranial cavity; consists of two layers including the periosteal layer and the meningeal layer http://purl.obolibrary.org/obo/MP_0009026 abnormal brain pia mater morphology http://purl.obolibrary.org/obo/MP_0009022 abnormal brain meninges morphology any structural anomaly of the fibrous membrane forming the innermost of the three coverings that surrounds the brain within the cranial cavity that is firmly attached to the glial capsule http://purl.obolibrary.org/obo/MP_0009027 abnormal subarachnoid space morphology http://purl.obolibrary.org/obo/MP_0005623 abnormal meninges morphology any structural anomaly of the space between the arachnoid and pia mater that is traversed by fibrous trabeculae and contains cerebrospinal fluid http://purl.obolibrary.org/obo/MP_0009028 abnormal chiasmatic cistern morphology http://purl.obolibrary.org/obo/MP_0009032 abnormal subarachnoid cistern morphology any structural anomaly of the region of the subarachnoid space that is located below and anterior to the optic chiasm http://purl.obolibrary.org/obo/MP_0009029 abnormal basal cistern morphology http://purl.obolibrary.org/obo/MP_0009032 abnormal subarachnoid cistern morphology any structural anomaly of the enclosed space where the arachnoid membrane stretches between the two temporal lobes and encloses the cerebral peduncles including the structures contained in the interpeduncular fossa http://purl.obolibrary.org/obo/MP_0009030 abnormal pontine cistern morphology http://purl.obolibrary.org/obo/MP_0009032 abnormal subarachnoid cistern morphology any structural anomaly of the space located on lateral aspects of the pons at the junction with the cerebellum http://purl.obolibrary.org/obo/MP_0009031 abnormal cerebellomedullary cistern morphology http://purl.obolibrary.org/obo/MP_0009032 abnormal subarachnoid cistern morphology any structural anomaly of the largest of the subarachnoid spaces between the cerebellum and the medulla oblongata http://purl.obolibrary.org/obo/MP_0009032 abnormal subarachnoid cistern morphology http://purl.obolibrary.org/obo/MP_0009027 abnormal subarachnoid space morphology any structural anomaly of the widening portions of the subarachnoid space within the cranium where the arachnoid bridges over a depression on the surface of the brain http://purl.obolibrary.org/obo/MP_0009033 abnormal posterior cerebellomedullary cistern http://purl.obolibrary.org/obo/MP_0009031 abnormal cerebellomedullary cistern morphology any structural anomaly of the space between the cerebellum and the dorsal surface of the medulla http://purl.obolibrary.org/obo/MP_0009034 abnormal lateral cerebellomedullary cistern morphology http://purl.obolibrary.org/obo/MP_0009031 abnormal cerebellomedullary cistern morphology any structural anomaly of the space between the cerebellum and the lateral aspect of the medulla http://purl.obolibrary.org/obo/MP_0009035 abnormal quadrigeminal cistern morphology http://purl.obolibrary.org/obo/MP_0009032 abnormal subarachnoid cistern morphology any structural anomaly of the enclosed space extending forward between the corpus callosum and the thalamus that contains the internal cerebral veins http://purl.obolibrary.org/obo/MP_0009036 absent posterior cerebellomedullary cistern http://purl.obolibrary.org/obo/MP_0009033 abnormal posterior cerebellomedullary cistern absence of the space between the cerebellum and the dorsal surface of the medulla http://purl.obolibrary.org/obo/MP_0009037 abnormal subarachnoid space development http://purl.obolibrary.org/obo/MP_0009027 abnormal subarachnoid space morphology anomaly in the formation of the space between the arachnoid and pia mater that is traversed by fibrous trabeculae and contains cerebrospinal fluid http://purl.obolibrary.org/obo/MP_0009038 decreased inferior colliculus size http://purl.obolibrary.org/obo/MP_0000776 abnormal inferior colliculus morphology decreased size of the paired inferior eminence of the mesencephalic tectum http://purl.obolibrary.org/obo/MP_0009039 absent inferior colliculus http://purl.obolibrary.org/obo/MP_0000776 abnormal inferior colliculus morphology absence of the paired inferior eminence of the mesencephalic tectum http://purl.obolibrary.org/obo/MP_0009040 absent superior colliculus http://purl.obolibrary.org/obo/MP_0000904 abnormal superior colliculus morphology absence of the paired superior eminence of the mesencephalic tectum http://purl.obolibrary.org/obo/MP_0009041 absent colliculi http://purl.obolibrary.org/obo/MP_0000899 abnormal corpora quadrigemina morphology absence of the inferior and superior colliculus http://purl.obolibrary.org/obo/MP_0009042 pilar cyst http://purl.obolibrary.org/obo/MP_0001191 abnormal skin condition an epithelial cyst of the skin arising from the outer root sheath of the hair follicle http://purl.obolibrary.org/obo/MP_0009044 increased adrenal gland adenoma incidence http://purl.obolibrary.org/obo/MP_0010383 increased adenoma incidence greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the adrenal gland, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0009045 muscle tetany http://purl.obolibrary.org/obo/MP_0000743 muscle spasm a condition of mineral imbalance in the body that results in severe muscle spasms occurring when the concentration of calcium ions (Ca++) in extracellular fluids such as plasma falls below normal http://purl.obolibrary.org/obo/MP_0009047 short metestrus http://purl.obolibrary.org/obo/MP_0009019 abnormal metestrus decrease in the length of the metestrous phase of the estrous cycle in female animals http://purl.obolibrary.org/obo/MP_0009048 enlarged tectum http://purl.obolibrary.org/obo/MP_0006104 abnormal tectum morphology increased size of the rostral part of the midbrain roof http://purl.obolibrary.org/obo/MP_0009049 abnormal hallux morphology http://purl.obolibrary.org/obo/MP_0002110 abnormal digit morphology any structural anomaly of the first or primary digit of the foot http://purl.obolibrary.org/obo/MP_0009050 dilated proximal convoluted tubules http://purl.obolibrary.org/obo/MP_0004756 abnormal proximal convoluted tubule morphology stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle http://purl.obolibrary.org/obo/MP_0009051 dilated distal convoluted tubules http://purl.obolibrary.org/obo/MP_0004757 abnormal distal convoluted tubule morphology stretched or widened aperture of the luminal space of the convoluted portion of the duct system of the nephron between the ascending portion of the loop of Henle and the collecting duct system in the kidney cortex http://purl.obolibrary.org/obo/MP_0009052 anal stenosis http://purl.obolibrary.org/obo/MP_0005034 abnormal anus morphology abnormal narrowing or constriction of the anal orifice http://purl.obolibrary.org/obo/MP_0009054 absent anal canal http://purl.obolibrary.org/obo/MP_0009053 abnormal anal canal morphology absence of the terminal portion of the alimentary canal http://purl.obolibrary.org/obo/MP_0009055 abnormal internal anal sphincter morphology http://purl.obolibrary.org/obo/MP_0009053 abnormal anal canal morphology any structural anomaly of the smooth muscle ring, formed by an increase of the circular muscle fibers of the rectum, situated at the upper end of the anal canal, internal to the outer voluntary external anal sphincter http://purl.obolibrary.org/obo/MP_0009056 abnormal interleukin-21 secretion http://purl.obolibrary.org/obo/MP_0008568 abnormal interleukin secretion anomaly in the production or release of a pleiotropic cytokine that regulates immunoglobulin production, plasma cell and Th17 T cell differentiation, CD8+ T cell expansion, and inhibits antigen presentation by dendritic cells http://purl.obolibrary.org/obo/MP_0009057 increased interleukin-21 secretion http://purl.obolibrary.org/obo/MP_0009056 abnormal interleukin-21 secretion increase in the production or release of a pleiotropic cytokine that regulates immunoglobulin production, plasma cell and Th17 T cell differentiation, CD8+ T cell expansion, and inhibits antigen presentation by dendritic cells http://purl.obolibrary.org/obo/MP_0009058 decreased interleukin-21 secretion http://purl.obolibrary.org/obo/MP_0009056 abnormal interleukin-21 secretion reduction in the production or release of a pleiotropic cytokine that regulates immunoglobulin production, plasma cell and Th17 T cell differentiation, CD8+ T cell expansion, and inhibits antigen presentation by dendritic cells http://purl.obolibrary.org/obo/MP_0009059 abnormal circulating interleukin-21 level http://purl.obolibrary.org/obo/MP_0008588 abnormal circulating interleukin level anomaly in the amount in the blood of a pleiotropic cytokine that regulates immunoglobulin production, plasma cell and Th17 T cell differentiation, CD8+ T cell expansion, and inhibits antigen presentation by dendritic cells http://purl.obolibrary.org/obo/MP_0009060 increased circulating interleukin-21 level http://purl.obolibrary.org/obo/MP_0009059 abnormal circulating interleukin-21 level increase in the amount in the blood of a pleiotropic cytokine that regulates immunoglobulin production, plasma cell and Th17 T cell differentiation, CD8+ T cell expansion, and inhibits antigen presentation by dendritic cells http://purl.obolibrary.org/obo/MP_0009061 decreased circulating interleukin-21 level http://purl.obolibrary.org/obo/MP_0009059 abnormal circulating interleukin-21 level reduction in the amount in the blood of a pleiotropic cytokine that regulates immunoglobulin production, plasma cell and Th17 T cell differentiation, CD8+ T cell expansion, and inhibits antigen presentation by dendritic cells http://purl.obolibrary.org/obo/MP_0009062 impaired lectin complement pathway http://purl.obolibrary.org/obo/MP_0002471 abnormal complement pathway abnormal function of the plasma protein cascade triggered by binding of lectin(s) to carbohydrate groups found on pathogen cell surfaces http://purl.obolibrary.org/obo/MP_0009063 abnormal oviduct size http://purl.obolibrary.org/obo/MP_0003574 abnormal oviduct morphology anomaly in the average size of the tube through which the ova pass from the ovary to the uterus http://purl.obolibrary.org/obo/MP_0009064 oviduct atrophy http://purl.obolibrary.org/obo/MP_0009070 small oviduct acquired diminution of the size of the oviduct associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0009065 abnormal oviduct weight http://purl.obolibrary.org/obo/MP_0009063 abnormal oviduct size anomaly in the average weight of the tube through which the ova pass from the ovary to the uterus http://purl.obolibrary.org/obo/MP_0009066 decreased oviduct weight http://purl.obolibrary.org/obo/MP_0009065 abnormal oviduct weight reduction in the average weight of the tube through which the ova pass from the ovary to the uterus http://purl.obolibrary.org/obo/MP_0009067 increased oviduct weight http://purl.obolibrary.org/obo/MP_0009068 enlarged oviduct greater average weight of the tube through which the ova pass from the ovary to the uterus http://purl.obolibrary.org/obo/MP_0009068 enlarged oviduct http://purl.obolibrary.org/obo/MP_0009063 abnormal oviduct size increased size of the tube through which the ova pass from the ovary to the uterus http://purl.obolibrary.org/obo/MP_0009069 dilated oviduct http://purl.obolibrary.org/obo/MP_0009063 abnormal oviduct size an expansion in the volume or area of the tube through which the ova pass from the ovary to the uterus, usually with an increase in contained fluid http://purl.obolibrary.org/obo/MP_0009071 short oviduct http://purl.obolibrary.org/obo/MP_0009070 small oviduct length reduction or truncation of the tube through which the ova pass from the ovary to the uterus http://purl.obolibrary.org/obo/MP_0009072 absent cranial vagina http://purl.obolibrary.org/obo/MP_0009077 abnormal cranial vagina morphology absence of the upper third of the female reproductive canal located between the uterus and the vulva, usually due to a developmental arrest or agenesis of the caudal Mullerian ducts http://purl.obolibrary.org/obo/MP_0009073 absent Wolffian ducts http://purl.obolibrary.org/obo/MP_0003827 abnormal Wolffian duct morphology absence of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and later develop into the ductus deferens in the male http://purl.obolibrary.org/obo/MP_0009074 Wolffian duct degeneration http://purl.obolibrary.org/obo/MP_0003827 abnormal Wolffian duct morphology a retrogressive impairment of function or destruction of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and later develop into the ductus deferens in the male http://purl.obolibrary.org/obo/MP_0009075 rudimentary Wolffian ducts http://purl.obolibrary.org/obo/MP_0003827 abnormal Wolffian duct morphology not fully developed or remnants of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and later develop into the ductus deferens in the male http://purl.obolibrary.org/obo/MP_0009076 rudimentary Mullerian ducts http://purl.obolibrary.org/obo/MP_0003826 abnormal Mullerian duct morphology not fully developed or remnants of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and in the female develop into the oviducts, uterus, and cranial vagina http://purl.obolibrary.org/obo/MP_0009077 abnormal cranial vagina morphology http://purl.obolibrary.org/obo/MP_0001139 abnormal vagina morphology any structural anomaly of the upper third of the female reproductive canal located between the uterus and the vulva, usually due to a developmental arrest or agenesis of the caudal Mullerian ducts http://purl.obolibrary.org/obo/MP_0009078 adrenal gland hyperplasia http://purl.obolibrary.org/obo/MP_0000642 enlarged adrenal glands overdevelopment or increased size, usually due to a increased number of cells, of the endocrine glands located above the kidney and responsible for hormone and epinephrine secretion http://purl.obolibrary.org/obo/MP_0009079 prolapsed intervertebral disk http://purl.obolibrary.org/obo/MP_0004173 abnormal intervertebral disk morphology extrusion of the cartilaginous and gelatinous structure found between vertebrae http://purl.obolibrary.org/obo/MP_0009080 uterus inflammation http://purl.obolibrary.org/obo/MP_0009671 abnormal uterus physiology local accumulation of fluid, plasma proteins, and leukocytes in the uterus http://purl.obolibrary.org/obo/MP_0009081 thin uterus http://purl.obolibrary.org/obo/MP_0002637 small uterus reduced thickness or depth of the female muscular organ of gestation http://purl.obolibrary.org/obo/MP_0009082 uterus cysts http://purl.obolibrary.org/obo/MP_0001120 abnormal uterus morphology presence of fluid-filled structures inside the lumen of the uterus; usually refers to benign growths http://purl.obolibrary.org/obo/MP_0009083 uterus hypertrophy http://purl.obolibrary.org/obo/MP_0004906 enlarged uterus increase in the bulk size of the female muscular organ of gestation due to cell enlargement http://purl.obolibrary.org/obo/MP_0009084 blind uterus http://purl.obolibrary.org/obo/MP_0001120 abnormal uterus morphology presence of a female muscular organ of gestation that ends in a blind segment or sac and does not communicate with the cervix or vagina http://purl.obolibrary.org/obo/MP_0009085 abnormal uterine horn morphology http://purl.obolibrary.org/obo/MP_0001120 abnormal uterus morphology any structural anomaly of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet; uterine horns are anterior Mullerian duct-derived structures http://purl.obolibrary.org/obo/MP_0009086 blind uterine horn http://purl.obolibrary.org/obo/MP_0009085 abnormal uterine horn morphology presence of a blind-ended segment or pouch at the junction of the uterine horn and the uterine body; the blind horn is typically distended by fluid http://purl.obolibrary.org/obo/MP_0009087 dilated uterine horn http://purl.obolibrary.org/obo/MP_0009085 abnormal uterine horn morphology an expansion in the volume or area of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet, usually with an increase in contained fluid http://purl.obolibrary.org/obo/MP_0009088 thin uterine horn http://purl.obolibrary.org/obo/MP_0009085 abnormal uterine horn morphology reduced thickness of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet http://purl.obolibrary.org/obo/MP_0009089 short uterine horn http://purl.obolibrary.org/obo/MP_0009085 abnormal uterine horn morphology length reduction or truncation of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet http://purl.obolibrary.org/obo/MP_0009090 myometrium hypoplasia http://purl.obolibrary.org/obo/MP_0008256 abnormal myometrium morphology underdevelopment or reduced size, usually due to a reduced number of cells, of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium http://purl.obolibrary.org/obo/MP_0009091 endometrium hypoplasia http://purl.obolibrary.org/obo/MP_0004896 abnormal endometrium morphology underdevelopment or reduced size, usually due to a reduced number of cells, of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy http://purl.obolibrary.org/obo/MP_0009092 endometrium hyperplasia http://purl.obolibrary.org/obo/MP_0004896 abnormal endometrium morphology overdevelopment or increased size, usually due an increased number of cells, of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy http://purl.obolibrary.org/obo/MP_0009093 oocyte degeneration http://purl.obolibrary.org/obo/MP_0006361 abnormal female germ cell morphology a retrogressive impairment of function or destruction of the female germ cells http://purl.obolibrary.org/obo/MP_0009094 abnormal endometrial gland morphology http://purl.obolibrary.org/obo/MP_0004896 abnormal endometrium morphology any structural anomaly of the numerous simple or branched tubular glands lined by ciliated columnar epithelium and found in the mucus membrane of the uterus which secrete mucus, lipids, glycogen, and protein; endometrial glands and their secretions (termed histotroph) are critical regulators of peri-implantation embryo survival and implantation as well as establishment of uterine receptivity http://purl.obolibrary.org/obo/MP_0009095 abnormal endometrial gland number http://purl.obolibrary.org/obo/MP_0009094 abnormal endometrial gland morphology abnormal number of the simple or branched tubular glands located in the mucous membrane of the uterus http://purl.obolibrary.org/obo/MP_0009096 decreased endometrial gland number http://purl.obolibrary.org/obo/MP_0009095 abnormal endometrial gland number fewer than normal numbers of the simple or branched tubular glands found in the mucus membrane of the uterus http://purl.obolibrary.org/obo/MP_0009097 absent endometrial glands http://purl.obolibrary.org/obo/MP_0009095 abnormal endometrial gland number absence of the simple or branched tubular uterine glands http://purl.obolibrary.org/obo/MP_0009098 anovaginal fistula http://purl.obolibrary.org/obo/MP_0009053 abnormal anal canal morphology an abnormal anatomical passage that connects the anal canal and the vagina http://purl.obolibrary.org/obo/MP_0009099 abnormal uterine NK cell physiology http://purl.obolibrary.org/obo/MP_0010766 abnormal NK cell physiology any functional anomaly of a natural killer cell subset that is found in the decidual of the uterus, is CD56-high, Galectin-1-positive and CD16-negative, and is the most abundant immune cell type in the decidual during the first trimester of pregnancy http://purl.obolibrary.org/obo/MP_0009101 clitoris hypoplasia http://purl.obolibrary.org/obo/MP_0003530 small clitoris underdevelopment or reduced size of the clitoris, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0009103 abnormal penile bone morphology http://purl.obolibrary.org/obo/MP_0009102 abnormal glans penis morphology any structural anomaly of the unique bone located in the glans penis of most mammals except humans; it is used for copulation and varies in size and shape by species http://purl.obolibrary.org/obo/MP_0009104 small penile bone http://purl.obolibrary.org/obo/MP_0009103 abnormal penile bone morphology size reduction or truncation of the unique bone of variable size and shape located in the glans penis of most mammals except humans http://purl.obolibrary.org/obo/MP_0009105 penis prolapse http://purl.obolibrary.org/obo/MP_0005187 abnormal penis morphology inability to withdraw the penis into the prepuce (the fold of skin covering the glans penis), other than a paraphimosis; not to be confused with phimosis http://purl.obolibrary.org/obo/MP_0009107 abnormal pancreas weight http://purl.obolibrary.org/obo/MP_0009106 abnormal pancreas size anomaly in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream http://purl.obolibrary.org/obo/MP_0009108 increased pancreas weight http://purl.obolibrary.org/obo/MP_0009107 abnormal pancreas weight increase in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream http://purl.obolibrary.org/obo/MP_0009109 decreased pancreas weight http://purl.obolibrary.org/obo/MP_0009107 abnormal pancreas weight reduction in the average weight of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream http://purl.obolibrary.org/obo/MP_0009111 pancreas hypoplasia http://purl.obolibrary.org/obo/MP_0004247 small pancreas underdevelopment or reduced size of the pancreas, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0009112 abnormal pancreatic beta cell mass http://purl.obolibrary.org/obo/MP_0005217 abnormal pancreatic beta cell morphology anomaly in the total physical bulk or volume of a pancreatic beta cell compared to the normal state http://purl.obolibrary.org/obo/MP_0009113 increased pancreatic beta cell mass http://purl.obolibrary.org/obo/MP_0009112 abnormal pancreatic beta cell mass greater total physical bulk or volume of a pancreatic beta cell compared to the normal state http://purl.obolibrary.org/obo/MP_0009114 decreased pancreatic beta cell mass http://purl.obolibrary.org/obo/MP_0009112 abnormal pancreatic beta cell mass reduced total physical bulk or volume of a pancreatic beta cell compared to the normal state http://purl.obolibrary.org/obo/MP_0009115 abnormal fat cell morphology http://purl.obolibrary.org/obo/MP_0000003 abnormal adipose tissue morphology any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals http://purl.obolibrary.org/obo/MP_0009116 abnormal brown fat cell morphology http://purl.obolibrary.org/obo/MP_0009115 abnormal fat cell morphology any structural anomaly of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals; brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation; brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria http://purl.obolibrary.org/obo/MP_0009117 abnormal white fat cell morphology http://purl.obolibrary.org/obo/MP_0009115 abnormal fat cell morphology any structural anomaly of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole http://purl.obolibrary.org/obo/MP_0009118 increased white fat cell size http://purl.obolibrary.org/obo/MP_0009132 abnormal white fat cell size increase in the size of fat cells with light coloration and few mitochondria http://purl.obolibrary.org/obo/MP_0009119 increased brown fat cell size http://purl.obolibrary.org/obo/MP_0009135 abnormal brown fat cell size increase in the size of fat cells from the thermogenic form of adipose tissue http://purl.obolibrary.org/obo/MP_0009120 abnormal white fat cell lipid droplet size http://purl.obolibrary.org/obo/MP_0009117 abnormal white fat cell morphology anomaly in the size of the single large lipid droplet or vacuole of white fat cells http://purl.obolibrary.org/obo/MP_0009121 increased white fat cell lipid droplet size http://purl.obolibrary.org/obo/MP_0009120 abnormal white fat cell lipid droplet size increase in the size of the single large lipid droplet or vacuole of white fat cells http://purl.obolibrary.org/obo/MP_0009122 decreased white fat cell lipid droplet size http://purl.obolibrary.org/obo/MP_0009120 abnormal white fat cell lipid droplet size reduction in the size of the single large lipid droplet or vacuole of white fat cells http://purl.obolibrary.org/obo/MP_0009123 abnormal brown fat cell lipid droplet size http://purl.obolibrary.org/obo/MP_0009116 abnormal brown fat cell morphology anomaly in the size of the multiple small droplets of triglycerides found in brown adipocytes http://purl.obolibrary.org/obo/MP_0009124 increased brown fat cell lipid droplet size http://purl.obolibrary.org/obo/MP_0009123 abnormal brown fat cell lipid droplet size increase in the size of the multiple small droplets of triglycerides found in brown adipocytes http://purl.obolibrary.org/obo/MP_0009125 decreased brown fat cell lipid droplet size http://purl.obolibrary.org/obo/MP_0009123 abnormal brown fat cell lipid droplet size reduction in the size of the multiple small droplets of triglycerides found in brown adipocytes http://purl.obolibrary.org/obo/MP_0009126 abnormal brown fat cell number http://purl.obolibrary.org/obo/MP_0009116 abnormal brown fat cell morphology anomaly in the number of fat cells from the thermogenic form of adipose tissue http://purl.obolibrary.org/obo/MP_0009127 increased brown fat cell number http://purl.obolibrary.org/obo/MP_0009126 abnormal brown fat cell number increase in the number of fat cells from the thermogenic form of adipose tissue http://purl.obolibrary.org/obo/MP_0009128 decreased brown fat cell number http://purl.obolibrary.org/obo/MP_0009126 abnormal brown fat cell number reduction in the number of fat cells from the thermogenic form of adipose tissue http://purl.obolibrary.org/obo/MP_0009129 abnormal white fat cell number http://purl.obolibrary.org/obo/MP_0009117 abnormal white fat cell morphology anomaly in the number of fat cells with light coloration and few mitochondria http://purl.obolibrary.org/obo/MP_0009130 increased white fat cell number http://purl.obolibrary.org/obo/MP_0009129 abnormal white fat cell number increase in the number of fat cells with light coloration and few mitochondria http://purl.obolibrary.org/obo/MP_0009131 decreased white fat cell number http://purl.obolibrary.org/obo/MP_0009129 abnormal white fat cell number reduction in the number of fat cells with light coloration and few mitochondria http://purl.obolibrary.org/obo/MP_0009132 abnormal white fat cell size http://purl.obolibrary.org/obo/MP_0009117 abnormal white fat cell morphology anomaly in the size of fat cells with light coloration and few mitochondria http://purl.obolibrary.org/obo/MP_0009133 decreased white fat cell size http://purl.obolibrary.org/obo/MP_0009269 decreased fat cell size reduction in the size of fat cells with light coloration and few mitochondria http://purl.obolibrary.org/obo/MP_0009134 abnormal brown fat lipid droplet number http://purl.obolibrary.org/obo/MP_0009116 abnormal brown fat cell morphology anomaly in the number of the multiple small droplets of triglycerides found in brown adipocytes http://purl.obolibrary.org/obo/MP_0009135 abnormal brown fat cell size http://purl.obolibrary.org/obo/MP_0009116 abnormal brown fat cell morphology anomaly in the size of fat cells from the thermogenic form of adipose tissue http://purl.obolibrary.org/obo/MP_0009136 decreased brown fat cell size http://purl.obolibrary.org/obo/MP_0009269 decreased fat cell size reduction in the size of fat cells from the thermogenic form of adipose tissue http://purl.obolibrary.org/obo/MP_0009137 decreased brown fat lipid droplet number http://purl.obolibrary.org/obo/MP_0009134 abnormal brown fat lipid droplet number reduction in the number of the multiple small droplets of triglycerides found in brown adipocytes http://purl.obolibrary.org/obo/MP_0009138 increased brown fat lipid droplet number http://purl.obolibrary.org/obo/MP_0009134 abnormal brown fat lipid droplet number increase in the number of the multiple small droplets of triglycerides found in brown adipocytes http://purl.obolibrary.org/obo/MP_0009139 failure of Mullerian duct regression http://purl.obolibrary.org/obo/MP_0003826 abnormal Mullerian duct morphology failure of the transient embryonic paramesonephric ducts, which normally develop into the oviduct, uterus, cervix and upper vagina in the female, to regress in the male; persistence of Mullerian ducts is typically consistent with a loss of anti-Mullerian hormone signaling and may allow development of the female reproductive tract in males http://purl.obolibrary.org/obo/MP_0009140 dilated efferent ductules of testis http://purl.obolibrary.org/obo/MP_0004728 abnormal efferent ductules of testis morphology an expansion in the volume or area of the lumen of the small seminal ducts that lead from the testis to the head of the epididymis, usually with an increase in contained fluid http://purl.obolibrary.org/obo/MP_0009141 increased prepulse inhibition http://purl.obolibrary.org/obo/MP_0003088 abnormal prepulse inhibition increase in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus http://purl.obolibrary.org/obo/MP_0009142 decreased prepulse inhibition http://purl.obolibrary.org/obo/MP_0003088 abnormal prepulse inhibition decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus http://purl.obolibrary.org/obo/MP_0009143 abnormal pancreatic duct morphology http://purl.obolibrary.org/obo/MP_0005220 abnormal exocrine pancreas morphology any structural anomaly of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum http://purl.obolibrary.org/obo/MP_0009144 dilated pancreatic duct http://purl.obolibrary.org/obo/MP_0009143 abnormal pancreatic duct morphology an increase in volume of the luminal space of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum http://purl.obolibrary.org/obo/MP_0009145 abnormal pancreatic acinus morphology http://purl.obolibrary.org/obo/MP_0005220 abnormal exocrine pancreas morphology any structural anomaly of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct http://purl.obolibrary.org/obo/MP_0009146 abnormal pancreatic acinar cell morphology http://purl.obolibrary.org/obo/MP_0009145 abnormal pancreatic acinus morphology any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes http://purl.obolibrary.org/obo/MP_0009147 abnormal pancreatic acinar cell physiology http://purl.obolibrary.org/obo/MP_0010148 abnormal exocrine pancreas physiology any functional anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes http://purl.obolibrary.org/obo/MP_0009148 pancreas necrosis http://purl.obolibrary.org/obo/MP_0001944 abnormal pancreas morphology morphological changes resulting from pathological death of pancreas tissue; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0009149 decreased pancreatic acinar cell number http://purl.obolibrary.org/obo/MP_0009146 abnormal pancreatic acinar cell morphology reduced number of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes http://purl.obolibrary.org/obo/MP_0009150 pancreatic acinar cell atrophy http://purl.obolibrary.org/obo/MP_0013295 pancreas atrophy acquired diminution of the pancreatic acinar cells associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0009151 increased pancreatic ductal adenocarcinoma incidence http://purl.obolibrary.org/obo/MP_0009153 increased pancreas tumor incidence greater than the expected number of an adenocarcinoma that arises from the pancreatic ducts, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0009152 increased pancreatic intraepithelial neoplasia incidence http://purl.obolibrary.org/obo/MP_0009153 increased pancreas tumor incidence greater than the expected number of noninvasive pancreatic duct lesions that affect smaller caliber ducts and do not involve the main pancreatic duct, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0009153 increased pancreas tumor incidence http://purl.obolibrary.org/obo/MP_0010288 increased gland tumor incidence greater than the expected number of neoplams in the pancreas occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0009154 pancreatic acinar hypoplasia http://purl.obolibrary.org/obo/MP_0009145 abnormal pancreatic acinus morphology underdevelopment or reduced size of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced, usually due to a decreased cell number http://purl.obolibrary.org/obo/MP_0009155 pancreatic acinar hyperplasia http://purl.obolibrary.org/obo/MP_0009145 abnormal pancreatic acinus morphology overdevelopment or increased size of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced, usually due to an increased cell number http://purl.obolibrary.org/obo/MP_0009156 absent pancreatic acini http://purl.obolibrary.org/obo/MP_0009145 abnormal pancreatic acinus morphology absence of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct http://purl.obolibrary.org/obo/MP_0009157 ectopic pancreatic acinar cells http://purl.obolibrary.org/obo/MP_0009146 abnormal pancreatic acinar cell morphology abnormal position of one or more of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes http://purl.obolibrary.org/obo/MP_0009158 absent pancreatic acinar cells http://purl.obolibrary.org/obo/MP_0009146 abnormal pancreatic acinar cell morphology absence of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes http://purl.obolibrary.org/obo/MP_0009159 increased pancreatic acinar cell number http://purl.obolibrary.org/obo/MP_0009146 abnormal pancreatic acinar cell morphology increased number of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes http://purl.obolibrary.org/obo/MP_0009160 abnormal pancreatic acinar cell zymogen granule morphology http://purl.obolibrary.org/obo/MP_0009146 abnormal pancreatic acinar cell morphology any structural anomaly of a membrane-bounded, cytoplasmic secretory granule found in pancreatic acinar cells and contains inactive digestive enzyme precursors http://purl.obolibrary.org/obo/MP_0009161 pancreatic acinar cell zymogen granule accumulation http://purl.obolibrary.org/obo/MP_0009160 abnormal pancreatic acinar cell zymogen granule morphology a gradually increasing number of membrane-bounded, cytoplasmic secretory granules found in pancreatic acinar cells that contain inactive digestive enzyme precursors http://purl.obolibrary.org/obo/MP_0009162 absent pancreatic acinar cell zymogen granule http://purl.obolibrary.org/obo/MP_0009160 abnormal pancreatic acinar cell zymogen granule morphology absence of a membrane-bounded, cytoplasmic secretory granule found in pancreatic acinar cells and contains inactive digestive enzyme precursors http://purl.obolibrary.org/obo/MP_0009163 absent pancreatic duct http://purl.obolibrary.org/obo/MP_0009143 abnormal pancreatic duct morphology absence of the excretory duct of the exocrine pancreas that collects fluid containing digestive enzymes and transports it to the duodenum http://purl.obolibrary.org/obo/MP_0009164 exocrine pancreas atrophy http://purl.obolibrary.org/obo/MP_0013295 pancreas atrophy acquired diminution of the size of the acinar gland portion of the pancreas that secretes digestive enzymes, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0009165 abnormal endocrine pancreas morphology http://purl.obolibrary.org/obo/MP_0001944 abnormal pancreas morphology any structural anomaly of the smaller portion of the pancreas that secretes a number of hormones into the blood stream that are produced by the cells in the islets of Langerhans http://purl.obolibrary.org/obo/MP_0009166 abnormal pancreatic islet number http://purl.obolibrary.org/obo/MP_0005215 abnormal pancreatic islet morphology anomaly in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas http://purl.obolibrary.org/obo/MP_0009167 increased pancreatic islet number http://purl.obolibrary.org/obo/MP_0009166 abnormal pancreatic islet number increase in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas http://purl.obolibrary.org/obo/MP_0009168 decreased pancreatic islet number http://purl.obolibrary.org/obo/MP_0009166 abnormal pancreatic islet number reduction in the number of the clusters of hormone-producing cells that are scattered throughout the pancreas http://purl.obolibrary.org/obo/MP_0009169 pancreatic islet hypoplasia http://purl.obolibrary.org/obo/MP_0009172 small pancreatic islets underdevelopment or decreased size of the clusters of hormone-producing cells that are scattered throughout the pancreas, usually due an decreased number of cells http://purl.obolibrary.org/obo/MP_0009170 abnormal pancreatic islet size http://purl.obolibrary.org/obo/MP_0005215 abnormal pancreatic islet morphology anomaly in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas http://purl.obolibrary.org/obo/MP_0009171 enlarged pancreatic islets http://purl.obolibrary.org/obo/MP_0009170 abnormal pancreatic islet size increase in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas http://purl.obolibrary.org/obo/MP_0009172 small pancreatic islets http://purl.obolibrary.org/obo/MP_0009170 abnormal pancreatic islet size decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas http://purl.obolibrary.org/obo/MP_0009173 absent pancreatic islets http://purl.obolibrary.org/obo/MP_0005215 abnormal pancreatic islet morphology absence of the clusters of hormone-producing cells that are scattered throughout the pancreas http://purl.obolibrary.org/obo/MP_0009174 absent pancreatic beta cells http://purl.obolibrary.org/obo/MP_0003339 decreased pancreatic beta cell number absence of the cells of the pancreas that secrete insulin http://purl.obolibrary.org/obo/MP_0009175 abnormal pancreatic beta cell differentiation http://purl.obolibrary.org/obo/MP_0011932 abnormal endocrine pancreas development atypical production of or inability to produce the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas, and/or accumulation of pancreatic beta cell precursors http://purl.obolibrary.org/obo/MP_0009176 increased pancreatic alpha cell number http://purl.obolibrary.org/obo/MP_0005216 abnormal pancreatic alpha cell morphology increase in the number of the cells of the pancreas that secrete glucagon http://purl.obolibrary.org/obo/MP_0009177 decreased pancreatic alpha cell number http://purl.obolibrary.org/obo/MP_0005216 abnormal pancreatic alpha cell morphology reduction in the number of the cells of the pancreas that secrete glucagon http://purl.obolibrary.org/obo/MP_0009178 absent pancreatic alpha cells http://purl.obolibrary.org/obo/MP_0009177 decreased pancreatic alpha cell number absence of the cells of the pancreas that secrete glucagon http://purl.obolibrary.org/obo/MP_0009179 abnormal pancreatic alpha cell differentiation http://purl.obolibrary.org/obo/MP_0011932 abnormal endocrine pancreas development atypical production of or inability to produce the cells of the pancreas that secrete glucagon, and/or accumulation of pancreatic alpha cell precursors http://purl.obolibrary.org/obo/MP_0009180 increased pancreatic delta cell number http://purl.obolibrary.org/obo/MP_0005218 abnormal pancreatic delta cell morphology increased number of the cells found in the pancreas that secrete somatostatin http://purl.obolibrary.org/obo/MP_0009181 decreased pancreatic delta cell number http://purl.obolibrary.org/obo/MP_0005218 abnormal pancreatic delta cell morphology reduced number of the cells found in the pancreas that secrete somatostatin http://purl.obolibrary.org/obo/MP_0009182 absent pancreatic delta cells http://purl.obolibrary.org/obo/MP_0009181 decreased pancreatic delta cell number absence of the cells found in the pancreas that secrete somatostatin http://purl.obolibrary.org/obo/MP_0009183 abnormal pancreatic delta cell differentiation http://purl.obolibrary.org/obo/MP_0011932 abnormal endocrine pancreas development atypical production of or inability to produce the cells found in the pancreas that secrete somatostatin, and/or accumulation of pancreatic delta cell precursors http://purl.obolibrary.org/obo/MP_0009184 abnormal PP cell morphology http://purl.obolibrary.org/obo/MP_0005215 abnormal pancreatic islet morphology any structural anomaly of the polygonal pancreatic polypeptide producing cells in the islets of Langerhans in the pancreas http://purl.obolibrary.org/obo/MP_0009185 increased PP cell number http://purl.obolibrary.org/obo/MP_0009184 abnormal PP cell morphology increased number of the polygonal pancreatic polypeptide producing cells in the islets of Langerhans in the pancreas http://purl.obolibrary.org/obo/MP_0009186 decreased PP cell number http://purl.obolibrary.org/obo/MP_0009184 abnormal PP cell morphology reduced number of the polygonal pancreatic polypeptide producing cells in the islets of Langerhans in the pancreas http://purl.obolibrary.org/obo/MP_0009187 absent PP cells http://purl.obolibrary.org/obo/MP_0009186 decreased PP cell number absence of the polygonal pancreatic polypeptide producing cells in the islets of Langerhans in the pancreas http://purl.obolibrary.org/obo/MP_0009188 abnormal PP cell differentiation http://purl.obolibrary.org/obo/MP_0011932 abnormal endocrine pancreas development atypical production of or inability to produce the polygonal pancreatic polypeptide producing cells in the islets of Langerhans in the pancreas, and/or accumulation of PP cell precursors http://purl.obolibrary.org/obo/MP_0009189 abnormal pancreatic epsilon cell morphology http://purl.obolibrary.org/obo/MP_0005215 abnormal pancreatic islet morphology any structural anomaly of the endocrine cells found in the Islets of Langerhans that produce the hormone ghrelin http://purl.obolibrary.org/obo/MP_0009190 increased pancreatic epsilon cell number http://purl.obolibrary.org/obo/MP_0009189 abnormal pancreatic epsilon cell morphology increase in the number of the endocrine cells found in the Islets of Langerhans that produce the hormone ghrelin http://purl.obolibrary.org/obo/MP_0009191 decreased pancreatic epsilon cell number http://purl.obolibrary.org/obo/MP_0009189 abnormal pancreatic epsilon cell morphology reduction in the number of the endocrine cells found in the Islets of Langerhans that produce the hormone ghrelin http://purl.obolibrary.org/obo/MP_0009192 absent pancreatic epsilon cells http://purl.obolibrary.org/obo/MP_0009191 decreased pancreatic epsilon cell number absence of the endocrine cells found in the Islets of Langerhans that produce the hormone ghrelin http://purl.obolibrary.org/obo/MP_0009193 abnormal pancreatic epsilon cell differentiation http://purl.obolibrary.org/obo/MP_0011932 abnormal endocrine pancreas development atypical production of or inability to produce the endocrine cells found in the Islets of Langerhans that produce the hormone ghrelin, and/or accumulation of pancreatic epsilon cell precursors http://purl.obolibrary.org/obo/MP_0009194 abnormal pancreatic epsilon cell physiology http://purl.obolibrary.org/obo/MP_0010147 abnormal endocrine pancreas physiology any functional anomaly of the endocrine cells found in the Islets of Langerhans that produce the hormone ghrelin http://purl.obolibrary.org/obo/MP_0009195 abnormal PP cell physiology http://purl.obolibrary.org/obo/MP_0010147 abnormal endocrine pancreas physiology any functional anomaly of the polygonal pancreatic polypeptide producing cells in the islets of Langerhans in the pancreas http://purl.obolibrary.org/obo/MP_0009196 abnormal pancreatic ghrelin secretion http://purl.obolibrary.org/obo/MP_0009194 abnormal pancreatic epsilon cell physiology anomaly in the production and/or regulated release from pancreatic epsilon cells of a 28-amino acid, acylated, orexigenic peptide that acts centrally to stimulate growth hormone secretion and food intake, and peripherally to regulate energy homeostasis; it is cleaved from a large precursor protein, known as appetite-regulating hormone or motilin-related peptide, which contains both ghrelin and obestatin http://purl.obolibrary.org/obo/MP_0009197 abnormal pancreatic polypeptide secretion http://purl.obolibrary.org/obo/MP_0009195 abnormal PP cell physiology anomaly in the production and/or regulated release of the 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the islets of Langerhans in response to ingestions, and regulates gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite http://purl.obolibrary.org/obo/MP_0009198 abnormal male genitalia morphology http://purl.obolibrary.org/obo/MP_0001145 abnormal male reproductive system morphology any structural anomaly of the masculine organs of reproduction or generation, external or internal http://purl.obolibrary.org/obo/MP_0009200 enlarged external male genitalia http://purl.obolibrary.org/obo/MP_0009199 abnormal external male genitalia morphology increased size of the external masculine genital organs, including the penis and scrotum http://purl.obolibrary.org/obo/MP_0009201 external male genitalia atrophy http://purl.obolibrary.org/obo/MP_0009202 small external male genitalia acquired diminution of the size of the external masculine genital organs, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0009202 small external male genitalia http://purl.obolibrary.org/obo/MP_0009199 abnormal external male genitalia morphology reduced size of the external masculine genital organs http://purl.obolibrary.org/obo/MP_0009203 external male genitalia hypoplasia http://purl.obolibrary.org/obo/MP_0009202 small external male genitalia underdevelopment or reduced size of the external masculine genital organs, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0009204 absent external male genitalia http://purl.obolibrary.org/obo/MP_0009199 abnormal external male genitalia morphology absence of the external masculine genital organs, including the penis and scrotum http://purl.obolibrary.org/obo/MP_0009206 absent internal male genitalia http://purl.obolibrary.org/obo/MP_0009205 abnormal internal male genitalia morphology absence of the internal masculine genital organs, including the testes, epididymides, deferent ducts, seminal vesicles, prostate, ejaculatory ducts, and bulbourethral glands http://purl.obolibrary.org/obo/MP_0009207 internal male genitalia hypoplasia http://purl.obolibrary.org/obo/MP_0009205 abnormal internal male genitalia morphology underdevelopment or reduced size of the internal masculine genital organs, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0009210 absent internal female genitalia http://purl.obolibrary.org/obo/MP_0009209 abnormal internal female genitalia morphology absence of the internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina http://purl.obolibrary.org/obo/MP_0009211 absent external female genitalia http://purl.obolibrary.org/obo/MP_0003126 abnormal external female genitalia morphology absence of the external feminine genital organs, collectively known as the vulva http://purl.obolibrary.org/obo/MP_0009212 vulva atrophy http://purl.obolibrary.org/obo/MP_0003527 small vulva acquired diminution of the size of the external feminine genital organs, collectively known as the vulva, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0009213 absent male inguinal canal http://purl.obolibrary.org/obo/MP_0008016 abnormal male inguinal canal morphology absence of the passage in the lower abdominal wall through which the spermatic cord, nerves and vessels normally pass from the pelvic cavity to the scrotum http://purl.obolibrary.org/obo/MP_0009214 vas deferens hypoplasia http://purl.obolibrary.org/obo/MP_0002769 abnormal vas deferens morphology underdevelopment or reduced size of the vas deferens, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0009215 absent uterine horn http://purl.obolibrary.org/obo/MP_0009085 abnormal uterine horn morphology absence of either one of the pair of tubular extensions from the uterine body where the uterus and the uterine tubes meet http://purl.obolibrary.org/obo/MP_0009216 abnormal peritoneum morphology http://purl.obolibrary.org/obo/MP_0003257 abnormal abdominal wall morphology any structural anomaly of the serous sac, consisting of mesothelium and a thin external layer of irregular connective tissue, that lines the abdominopelvic cavity and covers most of the viscera contained therein; it forms two sacs: the peritoneal (or greater) sac and the omental bursa (lesser sac) connected by the omental foramen http://purl.obolibrary.org/obo/MP_0009217 abnormal peritoneal vaginal process morphology http://purl.obolibrary.org/obo/MP_0009216 abnormal peritoneum morphology any structural anomaly of the peritoneal diverticulum in the embryonic lower anterior abdominal wall that traverses the inguinal canal; in the male it forms the tunica vaginalis testis and normally loses its connection with the peritoneal cavity; a persistent processus vaginalis in the female is known as the canal of Nuck http://purl.obolibrary.org/obo/MP_0009218 absent peritoneal vaginal process http://purl.obolibrary.org/obo/MP_0009217 abnormal peritoneal vaginal process morphology absence of the peritoneal diverticulum in the embryonic lower anterior abdominal wall that traverses the inguinal canal http://purl.obolibrary.org/obo/MP_0009219 increased prostate intraepithelial neoplasia incidence http://purl.obolibrary.org/obo/MP_0010357 increased prostate gland tumor incidence higher than normal incidence of a non-invasive neoplastic proliferation of the epithelial cells that line the acini and the ducts of the prostate gland http://purl.obolibrary.org/obo/MP_0009220 increased prostate gland adenocarcinoma incidence http://purl.obolibrary.org/obo/MP_0010357 increased prostate gland tumor incidence higher than normal incidence of a malignant neoplasm arising from prostate tissue http://purl.obolibrary.org/obo/MP_0009221 uterus adenomyosis http://purl.obolibrary.org/obo/MP_0001120 abnormal uterus morphology a benign invasion of myometrium by endometrial tissue http://purl.obolibrary.org/obo/MP_0009223 increased uterus carcinoma incidence http://purl.obolibrary.org/obo/MP_0009222 increased uterus tumor incidence greater than the expected number of malignant neoplasms derived from uterine epithelial cells, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0009224 absent endometrium http://purl.obolibrary.org/obo/MP_0004896 abnormal endometrium morphology absence of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy http://purl.obolibrary.org/obo/MP_0009225 abnormal uterine cervix size http://purl.obolibrary.org/obo/MP_0001135 abnormal uterine cervix morphology anomaly in the size of the lower opening of the uterus to the vagina http://purl.obolibrary.org/obo/MP_0009226 small uterine cervix http://purl.obolibrary.org/obo/MP_0009225 abnormal uterine cervix size reduced size of the lower opening of the uterus to the vagina http://purl.obolibrary.org/obo/MP_0009227 uterine cervix hypoplasia http://purl.obolibrary.org/obo/MP_0009226 small uterine cervix underdevelopment or reduced size of the cervix, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0009228 uterine cervix inflammation http://purl.obolibrary.org/obo/MP_0009671 abnormal uterus physiology local accumulation of fluid, plasma proteins, and leukocytes in the cervix http://purl.obolibrary.org/obo/MP_0009229 abnormal median eminence morphology http://purl.obolibrary.org/obo/MP_0000837 abnormal hypothalamus morphology any structural anomaly of the raised area at the infundibular region of the hypothalamus where the secretions of the hypothalamic neurons (releasing and inhibiting regulatory hormones) collect before entering the capillary network of hypophyseal portal system http://purl.obolibrary.org/obo/MP_0009230 abnormal sperm head morphology http://purl.obolibrary.org/obo/MP_0005578 teratozoospermia any structural anomaly of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg http://purl.obolibrary.org/obo/MP_0009231 detached acrosome http://purl.obolibrary.org/obo/MP_0008898 abnormal acrosome morphology detachment or loss of adhesion of the acrosome cap from the sperm head nucleus http://purl.obolibrary.org/obo/MP_0009232 abnormal sperm nucleus morphology http://purl.obolibrary.org/obo/MP_0009230 abnormal sperm head morphology any structural anomaly of the sperm head nucleus, including an abnormal nuclear shape or defects in the compaction of nuclear chromatin http://purl.obolibrary.org/obo/MP_0009233 enlarged sperm head http://purl.obolibrary.org/obo/MP_0009230 abnormal sperm head morphology increased size of the head segment of the sperm cell http://purl.obolibrary.org/obo/MP_0009234 absent sperm head http://purl.obolibrary.org/obo/MP_0009230 abnormal sperm head morphology absence of the head segment of the sperm cell http://purl.obolibrary.org/obo/MP_0009235 small sperm head http://purl.obolibrary.org/obo/MP_0009230 abnormal sperm head morphology reduced size of the head segment of the sperm cell http://purl.obolibrary.org/obo/MP_0009236 pinhead sperm http://purl.obolibrary.org/obo/MP_0009230 abnormal sperm head morphology a sperm head that is unusually oblong in shape and much smaller than normal; typically, pinhead sperm result when the centrioles from which the sperm tails develop are not correctly aligned opposite the developing acrosome so that sperm heads are lost and absorbed during epididymal transit http://purl.obolibrary.org/obo/MP_0009237 kinked sperm flagellum http://purl.obolibrary.org/obo/MP_0008892 abnormal sperm flagellum morphology a sharp bend or zigzag in the sperm tail http://purl.obolibrary.org/obo/MP_0009238 coiled sperm flagellum http://purl.obolibrary.org/obo/MP_0008892 abnormal sperm flagellum morphology abnormal twisting of the sperm flagellum into coils or spirals http://purl.obolibrary.org/obo/MP_0009239 short sperm flagellum http://purl.obolibrary.org/obo/MP_0008892 abnormal sperm flagellum morphology decreased length of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility http://purl.obolibrary.org/obo/MP_0009240 elongated sperm flagellum http://purl.obolibrary.org/obo/MP_0008892 abnormal sperm flagellum morphology increased length of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility http://purl.obolibrary.org/obo/MP_0009241 thick sperm flagellum http://purl.obolibrary.org/obo/MP_0008892 abnormal sperm flagellum morphology increased thickness of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility http://purl.obolibrary.org/obo/MP_0009242 thin sperm flagellum http://purl.obolibrary.org/obo/MP_0008892 abnormal sperm flagellum morphology reduced thickness of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility http://purl.obolibrary.org/obo/MP_0009243 hairpin sperm flagellum http://purl.obolibrary.org/obo/MP_0008892 abnormal sperm flagellum morphology a structural alteration where the sperm flagellum becomes bent back (folded) on itself to form a hairpin (loop) structure; a sharp hairpin-like bend formation can disrupt the axial structures and cause the sperm tail to become kinked http://purl.obolibrary.org/obo/MP_0009244 abnormal acid-activated cation-mediated receptor currents http://purl.obolibrary.org/obo/MP_0002206 abnormal CNS synaptic transmission change in the measured amplitude, current density or duration of response to stimulation of acid-activated cation-mediated receptors http://purl.obolibrary.org/obo/MP_0009245 caudal rachischisis http://purl.obolibrary.org/obo/MP_0002151 abnormal neural tube morphology/development congenitial fissure of the vertebral column at the caudal end of the body http://purl.obolibrary.org/obo/MP_0009246 pale spleen http://purl.obolibrary.org/obo/MP_0000689 abnormal spleen morphology spleen lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition http://purl.obolibrary.org/obo/MP_0009247 meteorism http://purl.obolibrary.org/obo/MP_0001663 abnormal digestive system physiology condition in which excess gas accumulates in the gastrointestinal tract or peritoneal cavity, often resulting in abdominal distention, excess flatulence and/or belching http://purl.obolibrary.org/obo/MP_0009248 small caput epididymis http://purl.obolibrary.org/obo/MP_0002660 abnormal caput epididymis morphology decrease in the average size of the head of the epididymis http://purl.obolibrary.org/obo/MP_0009249 enlarged caput epididymis http://purl.obolibrary.org/obo/MP_0002660 abnormal caput epididymis morphology increase in the average size of the head of the epididymis http://purl.obolibrary.org/obo/MP_0009251 enlarged endometrial glands http://purl.obolibrary.org/obo/MP_0009094 abnormal endometrial gland morphology increase in the average size of the simple or branched tubular glands located in the mucous membrane of the uterus http://purl.obolibrary.org/obo/MP_0009252 absent urinary bladder http://purl.obolibrary.org/obo/MP_0000538 abnormal urinary bladder morphology absence of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys http://purl.obolibrary.org/obo/MP_0009253 abnormal sympathetic neuron physiology http://purl.obolibrary.org/obo/MP_0010055 abnormal sensory neuron physiology any functional anomaly of any of the neurons of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body's response to stressful situations http://purl.obolibrary.org/obo/MP_0009254 disorganized pancreatic islets http://purl.obolibrary.org/obo/MP_0005215 abnormal pancreatic islet morphology derangement of the normal pattern of the hormone-producing cells within an islet; normally, the beta cells occupy the central portion of the islet and are surrounded by a corona of alpha and delta cells http://purl.obolibrary.org/obo/MP_0009255 degranulated pancreatic beta cells http://purl.obolibrary.org/obo/MP_0005217 abnormal pancreatic beta cell morphology insulin-secreting cells of the pancreas do not contain vesicles containing insulin http://purl.obolibrary.org/obo/MP_0009256 enlarged corpus epididymis http://purl.obolibrary.org/obo/MP_0002661 abnormal corpus epididymis morphology increase in the average size of the body of the epididymis http://purl.obolibrary.org/obo/MP_0009257 dilated seminiferous tubules http://purl.obolibrary.org/obo/MP_0002216 abnormal seminiferous tubule morphology the luminal space of the seminiferous tubules is increased in volume or area, usually with an increase in contained fluid http://purl.obolibrary.org/obo/MP_0009258 abnormal thymocyte apoptosis http://purl.obolibrary.org/obo/MP_0006412 abnormal T cell apoptosis change in the timing or the number of immature T cells located in the thymus that are undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0009259 abnormal vestibular saccule duct morphology http://purl.obolibrary.org/obo/MP_0006089 abnormal vestibular saccule morphology any structural anomaly of the saccular portion of the utriculosaccular duct that normally extends from the sacculus to the endolymphatic duct http://purl.obolibrary.org/obo/MP_0009260 abnormal utricle duct morphology http://purl.obolibrary.org/obo/MP_0006090 abnormal utricle morphology any structural anomaly of the utricular portion of the utriculosaccular duct that normally extends from the utriculus to the endolymphatic duct http://purl.obolibrary.org/obo/MP_0009261 abnormal utricle valve morphology http://purl.obolibrary.org/obo/MP_0006090 abnormal utricle morphology any structural anomaly of the utriculo-endolymphatic (UE) valve which is located in the antero-inferior wall of the utricle at the orifice of the utricular duct and serves to regulate endolymph volume in the endolymphatic sac, the utricle and the canals http://purl.obolibrary.org/obo/MP_0009262 absent semicircular canal ampulla http://purl.obolibrary.org/obo/MP_0008488 abnormal semicircular canal ampulla morphology absence of the spherical enlargement at the base of each semicircular canal where they connect with the utricle, containing the crista ampullaris which detects movement of the fluid within the canals http://purl.obolibrary.org/obo/MP_0009263 abnormal eyelid fusion http://purl.obolibrary.org/obo/MP_0009651 abnormal eyelid development anomaly in the process by which the upper and lower eyelids are joined during development http://purl.obolibrary.org/obo/MP_0009264 failure of eyelid fusion http://purl.obolibrary.org/obo/MP_0009263 abnormal eyelid fusion the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development; normally fused by E17 in the mouse http://purl.obolibrary.org/obo/MP_0009265 delayed eyelid fusion http://purl.obolibrary.org/obo/MP_0009263 abnormal eyelid fusion later than average time of the joining of the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye http://purl.obolibrary.org/obo/MP_0009266 abnormal mesendoderm development http://purl.obolibrary.org/obo/MP_0001685 abnormal endoderm development failure or abnormality in the formation of the embryonic cell layer that gives rise to both the endoderm and mesoderm http://purl.obolibrary.org/obo/MP_0009267 abnormal cerebellum fissure morphology http://purl.obolibrary.org/obo/MP_0004097 abnormal cerebellar cortex morphology any structural anomaly of the deep furrows which divide the lobules of the cerebellum, including the postcentral, primary and secondary furrows http://purl.obolibrary.org/obo/MP_0009268 absent cerebellum fissure http://purl.obolibrary.org/obo/MP_0009267 abnormal cerebellum fissure morphology absence of the deep furrows which divide the lobules of the cerebellum, including the postcentral, primary and secondary furrows http://purl.obolibrary.org/obo/MP_0009269 decreased fat cell size http://purl.obolibrary.org/obo/MP_0009115 abnormal fat cell morphology reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals http://purl.obolibrary.org/obo/MP_0009270 abnormal guard hair length http://purl.obolibrary.org/obo/MP_0000397 abnormal guard hair morphology anomaly in the length of the long, straight truncal hairs that contain two air cells in the medulla http://purl.obolibrary.org/obo/MP_0009271 increased guard hair length http://purl.obolibrary.org/obo/MP_0009270 abnormal guard hair length increase in the length of the long, straight truncal hairs that contain two air cells in the medulla http://purl.obolibrary.org/obo/MP_0009272 decreased guard hair length http://purl.obolibrary.org/obo/MP_0009270 abnormal guard hair length reduction in the length of the long, straight truncal hairs that contain two air cells in the medulla http://purl.obolibrary.org/obo/MP_0009273 abnormal hair shaft melanin granule shape http://purl.obolibrary.org/obo/MP_0008731 abnormal hair shaft melanin granule morphology the form of pigment polymers in the hair shaft differs compared to controls http://purl.obolibrary.org/obo/MP_0009274 buphthalmos http://purl.obolibrary.org/obo/MP_0001296 macrophthalmia abnormal enlargement of the eye that is usually congenital and attended by symptoms of glaucoma http://purl.obolibrary.org/obo/MP_0009275 bruising http://purl.obolibrary.org/obo/MP_0008817 hematoma an injury to biological tissue in which the capillaries are damaged, allowing blood to seep into the surrounding tissue; it should not be confused with ecchymosis, though the terms are related http://purl.obolibrary.org/obo/MP_0009276 ecchymosis http://purl.obolibrary.org/obo/MP_0011514 skin hemorrhage an ecchymosis is a spot caused by loss of blood from a vessel; it implies a larger size than a petechiae, and has a more diffuse border than purpura; an ecchymosis can be caused by a bruise (which implies trauma), but can also be caused by bleeding diathesis http://purl.obolibrary.org/obo/MP_0009277 increased brain tumor incidence http://purl.obolibrary.org/obo/MP_0010281 increased nervous system tumor incidence greater than the expected number of abnormal rapidly proliferating cells in the brain, usually in the form of a distinct mass, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0009278 abnormal bone marrow cell physiology http://purl.obolibrary.org/obo/MP_0001545 abnormal hematopoietic system physiology any functional anomaly of any of the cells found in the bone marrow http://purl.obolibrary.org/obo/MP_0009279 abnormal activated sperm motility http://purl.obolibrary.org/obo/MP_0002674 abnormal sperm motility any anomaly in the type of sperm mobility that is observed in freshly ejaculated sperm and is thought to help propel the sperm through the female reproductive tract to the oviduct; normally, the flagellum of an activated sperm generates a symmetrical, lower amplitude waveform that drives the sperm in a relatively straight line http://purl.obolibrary.org/obo/MP_0009280 reduced activated sperm motility http://purl.obolibrary.org/obo/MP_0009279 abnormal activated sperm motility loss or reduction of the activated type of sperm mobility, resulting in immotile sperm that are generally unable to reach the uterotubal junction; decreases in activated sperm motility may result in reduced male fertility http://purl.obolibrary.org/obo/MP_0009281 abnormal hyperactivated sperm motility http://purl.obolibrary.org/obo/MP_0002674 abnormal sperm motility any anomaly in the type of sperm motility that is observed in most sperm recovered from the site of fertilization and is thought to help sperm detach from the oviductal epithelium, reach the site of fertilization, and penetrate the cumulus and zona pellucida of the oocyte; normally, once sperm from most species become hyperactivated, the flagellar beat becomes asymmetrical and higher amplitude, resulting in circular or figure-eight trajectories http://purl.obolibrary.org/obo/MP_0009282 reduced hyperactivated sperm motility http://purl.obolibrary.org/obo/MP_0009281 abnormal hyperactivated sperm motility loss or reduction of the hyperactivated type of sperm mobility, impairing the ability of sperm to reach the site of fertilization and to penetrate the oocyte vestments; a block in hyperactivated motility may also impair the ability of a sperm to fertilize an oocyte in vitro http://purl.obolibrary.org/obo/MP_0009283 decreased gonadal fat pad weight http://purl.obolibrary.org/obo/MP_0005335 abnormal gonadal fat pad morphology less than average weight of the encapsulated adipose tissue associated with the ovaries or testes http://purl.obolibrary.org/obo/MP_0009284 abnormal sympathetic neuron innervation pattern http://purl.obolibrary.org/obo/MP_0002184 abnormal innervation any changes in the placement, morphology or number of nerve fibers to sympathetic termini http://purl.obolibrary.org/obo/MP_0009285 increased gonadal fat pad weight http://purl.obolibrary.org/obo/MP_0005335 abnormal gonadal fat pad morphology greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes http://purl.obolibrary.org/obo/MP_0009286 increased abdominal fat pad weight http://purl.obolibrary.org/obo/MP_0000010 abnormal abdominal fat pad morphology greater than average weight of the encapsulated adipose tissue in the abdomen http://purl.obolibrary.org/obo/MP_0009287 decreased abdominal fat pad weight http://purl.obolibrary.org/obo/MP_0000010 abnormal abdominal fat pad morphology less than average weight of the encapsulated adipose tissue in the abdomen http://purl.obolibrary.org/obo/MP_0009288 increased epididymal fat pad weight http://purl.obolibrary.org/obo/MP_0006319 abnormal epididymal fat pad morphology greater than average weight of the encapsulated adipose tissue associated with the epididymis http://purl.obolibrary.org/obo/MP_0009289 decreased epididymal fat pad weight http://purl.obolibrary.org/obo/MP_0006319 abnormal epididymal fat pad morphology less than average weight of the encapsulated adipose tissue associated with the epididymis http://purl.obolibrary.org/obo/MP_0009290 increased femoral fat pad weight http://purl.obolibrary.org/obo/MP_0008905 abnormal femoral fat pad morphology greater than average weight of the encapsulated adipose tissue associated with the femur http://purl.obolibrary.org/obo/MP_0009291 decreased femoral fat pad weight http://purl.obolibrary.org/obo/MP_0008905 abnormal femoral fat pad morphology less than average weight of the encapsulated adipose tissue associated with the femur http://purl.obolibrary.org/obo/MP_0009292 increased inguinal fat pad weight http://purl.obolibrary.org/obo/MP_0005336 abnormal inguinal fat pad morphology greater than average weight of the encapsulated adipose tissue found in the groin http://purl.obolibrary.org/obo/MP_0009293 decreased inguinal fat pad weight http://purl.obolibrary.org/obo/MP_0005336 abnormal inguinal fat pad morphology less than average weight of the encapsulated adipose tissue found in the groin http://purl.obolibrary.org/obo/MP_0009294 increased interscapular fat pad weight http://purl.obolibrary.org/obo/MP_0006320 abnormal interscapular fat pad morphology greater than average weight of the encapsulated adipose tissue located between the scapulae http://purl.obolibrary.org/obo/MP_0009295 decreased interscapular fat pad weight http://purl.obolibrary.org/obo/MP_0006320 abnormal interscapular fat pad morphology less than average weight of the encapsulated adipose tissue located between the scapulae http://purl.obolibrary.org/obo/MP_0009296 increased mammary fat pad weight http://purl.obolibrary.org/obo/MP_0008904 abnormal mammary fat pad morphology greater than average weight of the encapsulated adipose tissue associated with the mammary gland http://purl.obolibrary.org/obo/MP_0009297 decreased mammary fat pad weight http://purl.obolibrary.org/obo/MP_0008904 abnormal mammary fat pad morphology less than average weight of the encapsulated adipose tissue associated with the mammary gland http://purl.obolibrary.org/obo/MP_0009298 increased mesenteric fat pad weight http://purl.obolibrary.org/obo/MP_0008903 abnormal mesenteric fat pad morphology greater than average weight of the encapsulated adipose tissue associated with the mesentery http://purl.obolibrary.org/obo/MP_0009299 decreased mesenteric fat pad weight http://purl.obolibrary.org/obo/MP_0008903 abnormal mesenteric fat pad morphology less than average weight of the encapsulated adipose tissue associated with the mesentery http://purl.obolibrary.org/obo/MP_0009300 increased parametrial fat pad weight http://purl.obolibrary.org/obo/MP_0008906 abnormal parametrial fat pad morphology greater than average weight of the encapsulated adipose tissue associated with the extension of the subserous coat of the uterus laterally between the layers of the broad ligament http://purl.obolibrary.org/obo/MP_0009301 decreased parametrial fat pad weight http://purl.obolibrary.org/obo/MP_0008906 abnormal parametrial fat pad morphology less than average weight of the encapsulated adipose tissue associated with the extension of the subserous coat of the uterus laterally between the layers of the broad ligament http://purl.obolibrary.org/obo/MP_0009302 increased renal fat pad weight http://purl.obolibrary.org/obo/MP_0008902 abnormal renal fat pad morphology greater than average weight of the encapsulated adipose tissue associated with the kidney http://purl.obolibrary.org/obo/MP_0009303 decreased renal fat pad weight http://purl.obolibrary.org/obo/MP_0008902 abnormal renal fat pad morphology less than average weight of the encapsulated adipose tissue associated with the kidney http://purl.obolibrary.org/obo/MP_0009304 increased retroperitoneal fat pad weight http://purl.obolibrary.org/obo/MP_0005337 abnormal retroperitoneal fat pad morphology greater than average weight of the encapsulated adipose tissue found on the dorsal side of the peritoneum http://purl.obolibrary.org/obo/MP_0009305 decreased retroperitoneal fat pad weight http://purl.obolibrary.org/obo/MP_0005337 abnormal retroperitoneal fat pad morphology less than average weight of the encapsulated adipose tissue found on the dorsal side of the peritoneum http://purl.obolibrary.org/obo/MP_0009306 increased uterine fat pad weight http://purl.obolibrary.org/obo/MP_0008900 abnormal uterine fat pad morphology greater than average weight of the encapsulated adipose tissue associated with the uterus http://purl.obolibrary.org/obo/MP_0009307 decreased uterine fat pad weight http://purl.obolibrary.org/obo/MP_0008900 abnormal uterine fat pad morphology less than average weight of the encapsulated adipose tissue associated with the uterus http://purl.obolibrary.org/obo/MP_0009309 increased small intestine adenocarcinoma incidence http://purl.obolibrary.org/obo/MP_0002957 increased intestinal adenocarcinoma incidence higher than normal incidence of a malignant neoplasm of epithelial cells in the small intestine http://purl.obolibrary.org/obo/MP_0009310 increased large intestine adenocarcinoma incidence http://purl.obolibrary.org/obo/MP_0002957 increased intestinal adenocarcinoma incidence higher than normal incidence of a malignant neoplasm of epithelial cells in the large intestine http://purl.obolibrary.org/obo/MP_0009311 increased duodenum adenocarcinoma incidence http://purl.obolibrary.org/obo/MP_0009309 increased small intestine adenocarcinoma incidence higher than normal incidence of a malignant neoplasm of epithelial cells in the duodenum http://purl.obolibrary.org/obo/MP_0009312 increased jejunum adenocarcinoma incidence http://purl.obolibrary.org/obo/MP_0009309 increased small intestine adenocarcinoma incidence higher than normal incidence of a malignant neoplasm of epithelial cells in the jejunum http://purl.obolibrary.org/obo/MP_0009313 increased cecum adenocarcinoma incidence http://purl.obolibrary.org/obo/MP_0009310 increased large intestine adenocarcinoma incidence higher than normal incidence of a malignant neoplasm of epithelial cells in the cecum http://purl.obolibrary.org/obo/MP_0009314 increased colon adenocarcinoma incidence http://purl.obolibrary.org/obo/MP_0009310 increased large intestine adenocarcinoma incidence higher than normal incidence of a malignant neoplasm of epithelial cells in the colon http://purl.obolibrary.org/obo/MP_0009315 increased rectum adenocarcinoma incidence http://purl.obolibrary.org/obo/MP_0009310 increased large intestine adenocarcinoma incidence higher than normal incidence of a malignant neoplasm of epithelial cells in the rectum http://purl.obolibrary.org/obo/MP_0009316 increased anal adenocarcinoma incidence http://purl.obolibrary.org/obo/MP_0009310 increased large intestine adenocarcinoma incidence higher than normal incidence of a malignant neoplasm of epithelial cells in the anal canal http://purl.obolibrary.org/obo/MP_0009317 increased follicular lymphoma incidence http://purl.obolibrary.org/obo/MP_0002023 increased B cell derived lymphoma incidence higher than normal incidence of malignant lymphoma arising from lymphoid follicular B cells which may be small or large http://purl.obolibrary.org/obo/MP_0009318 increased splenic marginal zone lymphoma incidence http://purl.obolibrary.org/obo/MP_0002023 increased B cell derived lymphoma incidence higher than normal incidence of neoplasms arising from the B cell-rich zones of the spleen http://purl.obolibrary.org/obo/MP_0009319 increased small lymphocytic lymphoma incidence http://purl.obolibrary.org/obo/MP_0002023 increased B cell derived lymphoma incidence higher than normal incidence of lymphocytic leukemia where the lymphocytes are not increased in the peripheral blood, but lymph nodes are enlarged and other lymphoid tissue or bone marrow is infiltrated by small lymphocytes http://purl.obolibrary.org/obo/MP_0009320 increased lymphoblastic lymphoma incidence http://purl.obolibrary.org/obo/MP_0002024 increased T cell derived lymphoma incidence higher than normal incidence of diffuse lymphoma with supradiaphragmatic distribution and T lymphocytes having convoluted nuclei http://purl.obolibrary.org/obo/MP_0009321 increased histiocytic sarcoma incidence http://purl.obolibrary.org/obo/MP_0012431 increased lymphoma incidence greater than the expected number of malignant tumors derived from histiocytes in a given population in a given time period http://purl.obolibrary.org/obo/MP_0009322 increased splenocyte apoptosis http://purl.obolibrary.org/obo/MP_0009340 abnormal splenocyte apoptosis increase in the number of spleen cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0009323 abnormal spleen development http://purl.obolibrary.org/obo/MP_0000689 abnormal spleen morphology aberrant formation or incomplete differentiation of the organ that filters blood and stores red corpuscles and platelets http://purl.obolibrary.org/obo/MP_0009324 absent hippocampal fimbria http://purl.obolibrary.org/obo/MP_0003005 abnormal hippocampal fimbria morphology absence of the flattened band of efferent fibers arising from the subiculum and medial border of the hippocampus, which eventually thickens to form the fornix and fibers of the hippocampal commissure http://purl.obolibrary.org/obo/MP_0009325 necrospermia http://purl.obolibrary.org/obo/MP_0002673 abnormal sperm number condition in which spermatozoa in seminal fluid are dead or motionless http://purl.obolibrary.org/obo/MP_0009326 absent maternal crouching http://purl.obolibrary.org/obo/MP_0001382 abnormal nursing females do not assume a position over young that facilitates suckling behavior http://purl.obolibrary.org/obo/MP_0009327 abnormal maternal grooming http://purl.obolibrary.org/obo/MP_0001386 abnormal maternal nurturing females show an anomaly in eliciting the cleaning or tactile stimulus level necessary to initiate nursing by offspring http://purl.obolibrary.org/obo/MP_0009328 delayed heart looping http://purl.obolibrary.org/obo/MP_0000269 abnormal heart looping late onset of the initiation and/or completion of looping of the primitive heart tube http://purl.obolibrary.org/obo/MP_0009329 abnormal primitive pit morphology http://purl.obolibrary.org/obo/MP_0002231 abnormal primitive streak morphology any structural anomaly of the small depression in the primitive streak that is caudal to the primitive node where the cells of the epiblast initially begin to invaginate during early embryogenesis http://purl.obolibrary.org/obo/MP_0009330 abnormal primitive groove morphology http://purl.obolibrary.org/obo/MP_0002231 abnormal primitive streak morphology any structural anomaly of the shallow valley that extends along the length of the primitive streak http://purl.obolibrary.org/obo/MP_0009331 absent primitive node http://purl.obolibrary.org/obo/MP_0004066 abnormal primitive node morphology absence of the regional thickening of cells at the rostral tip of the vertebrate primitive streak through which gastrulating cells migrate anteriorally to form tissues in the future head and neck; this region organizes the formation of the three embryonic layers and establishes the longitudinal axis and the polarity of the embryo http://purl.obolibrary.org/obo/MP_0009332 abnormal splenocyte morphology http://purl.obolibrary.org/obo/MP_0000689 abnormal spleen morphology any structural anomaly of a cell of the spleen http://purl.obolibrary.org/obo/MP_0009333 abnormal splenocyte physiology http://purl.obolibrary.org/obo/MP_0008737 abnormal spleen physiology any functional anomaly of a cell of the spleen http://purl.obolibrary.org/obo/MP_0009334 abnormal splenocyte proliferation http://purl.obolibrary.org/obo/MP_0009333 abnormal splenocyte physiology anomaly in the ability of a splenocyte cell population to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0009335 decreased splenocyte proliferation http://purl.obolibrary.org/obo/MP_0009334 abnormal splenocyte proliferation reduction in the expansion rate of a splenocyte cell population by cell division http://purl.obolibrary.org/obo/MP_0009336 increased splenocyte proliferation http://purl.obolibrary.org/obo/MP_0009334 abnormal splenocyte proliferation increase in the expansion rate of a splenocyte cell population by cell division http://purl.obolibrary.org/obo/MP_0009337 abnormal splenocyte number http://purl.obolibrary.org/obo/MP_0009332 abnormal splenocyte morphology deviation from the expected number of cells of the spleen http://purl.obolibrary.org/obo/MP_0009338 increased splenocyte number http://purl.obolibrary.org/obo/MP_0009337 abnormal splenocyte number increase in the expected number of cells of the spleen http://purl.obolibrary.org/obo/MP_0009339 decreased splenocyte number http://purl.obolibrary.org/obo/MP_0009337 abnormal splenocyte number reduction in the expected number of cells of the spleen http://purl.obolibrary.org/obo/MP_0009340 abnormal splenocyte apoptosis http://purl.obolibrary.org/obo/MP_0009333 abnormal splenocyte physiology deviation in the number of spleen cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0009341 decreased splenocyte apoptosis http://purl.obolibrary.org/obo/MP_0009340 abnormal splenocyte apoptosis reduction in the number of spleen cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0009342 enlarged gallbladder http://purl.obolibrary.org/obo/MP_0005084 abnormal gallbladder morphology increased size of the gall bladder, the organ that serves as a storage reservoir for bile http://purl.obolibrary.org/obo/MP_0009343 dilated gallbladder http://purl.obolibrary.org/obo/MP_0005084 abnormal gallbladder morphology abnormal distention of the gall bladder due to accumulation of fluid or bile http://purl.obolibrary.org/obo/MP_0009345 abnormal trabecular bone thickness http://purl.obolibrary.org/obo/MP_0000130 abnormal trabecular bone morphology anomaly in the width of bone that has a lattice-like or spongy structure http://purl.obolibrary.org/obo/MP_0009346 decreased trabecular bone thickness http://purl.obolibrary.org/obo/MP_0009345 abnormal trabecular bone thickness thinner than normal bone with a lattice-like or spongy structure http://purl.obolibrary.org/obo/MP_0009347 increased trabecular bone thickness http://purl.obolibrary.org/obo/MP_0009345 abnormal trabecular bone thickness thicker than normal bone with a lattice-like or spongy structure http://purl.obolibrary.org/obo/MP_0009348 abnormal urine pH http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis any anomaly in urinary pH, indicating alterations in urine acidity or alkalinity http://purl.obolibrary.org/obo/MP_0009349 increased urine pH http://purl.obolibrary.org/obo/MP_0009348 abnormal urine pH increased urine alkalinity http://purl.obolibrary.org/obo/MP_0009350 decreased urine pH http://purl.obolibrary.org/obo/MP_0009348 abnormal urine pH increased urine acidity http://purl.obolibrary.org/obo/MP_0009351 thin hair shaft http://purl.obolibrary.org/obo/MP_0003809 abnormal hair shaft morphology the average diameter of coat hair is less than the average diameter of hair from normal individuals http://purl.obolibrary.org/obo/MP_0009352 impaired spacing of implantation sites http://purl.obolibrary.org/obo/MP_0001727 abnormal embryo implantation in organisms which give birth to multiple offspring in one litter, blastocysts fail to implant at intervals conducive to the formation of a normal enveloping membrane or decidua for each conceptus from the epithelial tissue of the endometrium lining of the uterus http://purl.obolibrary.org/obo/MP_0009353 twin decidual capsule http://purl.obolibrary.org/obo/MP_0001727 abnormal embryo implantation two embryos share one decidual membrane http://purl.obolibrary.org/obo/MP_0009354 emprosthotonos http://purl.obolibrary.org/obo/MP_0003492 abnormal involuntary movement a form of tetanic spasm in which the head and feet are drawn forward and the spine arches backward http://purl.obolibrary.org/obo/MP_0009355 increased liver triglyceride level http://purl.obolibrary.org/obo/MP_0012778 abnormal liver triglyceride level greater concentration of naturally occurring esters of three fatty acids and glycerol in the liver; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver http://purl.obolibrary.org/obo/MP_0009356 decreased liver triglyceride level http://purl.obolibrary.org/obo/MP_0012778 abnormal liver triglyceride level reduced concentration of naturally occurring esters of three fatty acids and glycerol in the liver; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liverower than normal concentration of triacylglycerols in the liver http://purl.obolibrary.org/obo/MP_0009359 endometrium atrophy http://purl.obolibrary.org/obo/MP_0004896 abnormal endometrium morphology acquired diminution of the size of the uterine endometrium, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0009360 endometrium inflammation http://purl.obolibrary.org/obo/MP_0009080 uterus inflammation local accumulation of fluid, plasma proteins, and leukocytes in the endometrium http://purl.obolibrary.org/obo/MP_0009361 abnormal primordial ovarian follicle morphology http://purl.obolibrary.org/obo/MP_0001131 abnormal ovarian follicle morphology any structural anomaly in the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles http://purl.obolibrary.org/obo/MP_0009362 abnormal primary ovarian follicle morphology http://purl.obolibrary.org/obo/MP_0001131 abnormal ovarian follicle morphology any structural anomaly in the ovarian follicle prior to the appearance of an antrum, normally marked by developmental changes in the primary oocyte and follicular cells so that the latter form one or more layers of cuboidal or columnar cells; the follicle becomes surrounded by a sheath of stroma, the theca http://purl.obolibrary.org/obo/MP_0009363 abnormal secondary ovarian follicle morphology http://purl.obolibrary.org/obo/MP_0001131 abnormal ovarian follicle morphology any structural anomaly in the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers http://purl.obolibrary.org/obo/MP_0009365 abnormal theca folliculi http://purl.obolibrary.org/obo/MP_0009363 abnormal secondary ovarian follicle morphology any structural anomaly in the envelope of condensed connective tissue surrounding a secondary ovarian follicle; the theca folliculi are divided into two layers, an internal vascular layer (tunica interna) and an external fibrous layer (tunica externa) http://purl.obolibrary.org/obo/MP_0009366 abnormal theca interna http://purl.obolibrary.org/obo/MP_0009365 abnormal theca folliculi any structural anomaly in the inner cellular and vascular layer of the theca of a secondary ovarian follicle; evidence indicates that the epithelioid cells produce androgens and contribute to the formation of the corpus luteum after ovulation http://purl.obolibrary.org/obo/MP_0009367 abnormal theca externa http://purl.obolibrary.org/obo/MP_0009365 abnormal theca folliculi any structural anomaly in the external fibrous layer of the theca of a secondary ovarian follicle; the theca externa contains abundant collagen and is mainly supportive http://purl.obolibrary.org/obo/MP_0009368 absent theca folliculi http://purl.obolibrary.org/obo/MP_0009365 abnormal theca folliculi absence of the internal, external or both layers of the sheath of stroma surrounding a secondary ovarian follicle http://purl.obolibrary.org/obo/MP_0009369 abnormal theca cell number http://purl.obolibrary.org/obo/MP_0009363 abnormal secondary ovarian follicle morphology abnormal numbers of cells in the sheath of stroma surrounding a secondary ovarian follicle http://purl.obolibrary.org/obo/MP_0009370 decreased theca cell number http://purl.obolibrary.org/obo/MP_0009369 abnormal theca cell number fewer than normal numbers of cells in the sheath of stroma surrounding a secondary ovarian follicle http://purl.obolibrary.org/obo/MP_0009371 increased theca cell number http://purl.obolibrary.org/obo/MP_0009369 abnormal theca cell number greater than normal numbers of cells in the sheath of stroma surrounding a secondary ovarian follicle http://purl.obolibrary.org/obo/MP_0009372 abnormal cumulus oophorus http://purl.obolibrary.org/obo/MP_0003357 impaired granulosa cell differentiation atypical formation of or inability to produce a mass of epithelial granulosa cells around the oocyte in the maturing Graafian follicle; the cumulus oophorus begins to expand dramatically when cumulus cells are induced to synthesize hyaluronic acid which aggregates in a viscous intercellular matrix http://purl.obolibrary.org/obo/MP_0009373 abnormal cumulus expansion http://purl.obolibrary.org/obo/MP_0001130 abnormal ovarian folliculogenesis anomaly in the ability of the cumulus cells to synthesize and accumulate hyaluronan into an extracellular matrix (ECM), which provides an essential microenvironment for oocyte fertilization; this expanded ECM binds the oocyte and the cumulus cells together, protects the oocyte from the proteolytic and mechanical stresses during extrusion, and allows sperm binding, penetration, and fertilization http://purl.obolibrary.org/obo/MP_0009374 absent cumulus expansion http://purl.obolibrary.org/obo/MP_0009373 abnormal cumulus expansion complete inability of the cumulus cells to secrete an extensive extracellular matrix required for successful fertilization http://purl.obolibrary.org/obo/MP_0009375 thin zona pellucida http://purl.obolibrary.org/obo/MP_0003696 abnormal zona pellucida morphology reduced thickness of the solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation http://purl.obolibrary.org/obo/MP_0009376 abnormal manchette morphology http://purl.obolibrary.org/obo/MP_0006380 abnormal spermatid morphology any structural anomaly of the conic array of microtubules that invests the posterior nucleus of a spermatid, and is believed to play a role in definitive posterior head-shaping events during spermiogenesis http://purl.obolibrary.org/obo/MP_0009377 ectopic manchette http://purl.obolibrary.org/obo/MP_0009376 abnormal manchette morphology abnormal position of the conic array of microtubules that normally invests the posterior nucleus of a spermatid http://purl.obolibrary.org/obo/MP_0009378 abnormal endoplasmic reticulum morphology http://purl.obolibrary.org/obo/MP_0000358 abnormal cell morphology any structural anomaly of irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells http://purl.obolibrary.org/obo/MP_0009381 abnormal prostate gland dorsolateral lobe morphology http://purl.obolibrary.org/obo/MP_0001158 abnormal prostate gland morphology any structural anomaly of the rodent prostate lobe that lies in the triangular area between urethra and seminal vesicle http://purl.obolibrary.org/obo/MP_0009382 abnormal cardiac jelly morphology http://purl.obolibrary.org/obo/MP_0000267 abnormal heart development any structural anomaly of the gelatinous noncellular material between the endothelial lining and the myocardial layer of the developing heart http://purl.obolibrary.org/obo/MP_0009384 cardiac valve regurgitation http://purl.obolibrary.org/obo/MP_0011926 abnormal cardiac valve physiology the backward reflux of blood through a cardiac valve, due to insufficiency caused by disease, aging or congenital malformation http://purl.obolibrary.org/obo/MP_0009385 abnormal dermal pigmentation http://purl.obolibrary.org/obo/MP_0002095 abnormal skin pigmentation anomaly in the coloration of the dermal layer of the skin due to changes in the amount, shape, or distribution of cells producing pigment http://purl.obolibrary.org/obo/MP_0009386 abnormal dermal melanocyte morphology http://purl.obolibrary.org/obo/MP_0009385 abnormal dermal pigmentation any structural anomaly of the cells that produce pigment in the dermis http://purl.obolibrary.org/obo/MP_0009387 abnormal epidermal pigmentation http://purl.obolibrary.org/obo/MP_0002095 abnormal skin pigmentation anomaly in the coloration of the epidermal layer of the skin due to changes in the amount, shape, or distribution of cells producing pigment http://purl.obolibrary.org/obo/MP_0009388 abnormal epidermal melanocyte morphology http://purl.obolibrary.org/obo/MP_0009387 abnormal epidermal pigmentation any structural anomaly of the cells that produce pigment in the epidermis http://purl.obolibrary.org/obo/MP_0009390 abnormal otic pigmentation http://purl.obolibrary.org/obo/MP_0009389 abnormal extracutaneous pigmentation any anomaly in the pigment or pigment-producing cells of the inner ear resulting in abnormal melanoblast numbers, distribution, or pigment during development http://purl.obolibrary.org/obo/MP_0009391 abnormal leptomeninges pigmentation http://purl.obolibrary.org/obo/MP_0009389 abnormal extracutaneous pigmentation any anomaly in the coloring of the two innermost layers of the meninges, including the pia mater and the arachnoid, due to changes in the amount, shape, or distribution of cells producing pigment http://purl.obolibrary.org/obo/MP_0009392 retinal gliosis http://purl.obolibrary.org/obo/MP_0001325 abnormal retina morphology increased proliferation of neuroglia in a damaged area of the retina that may lead to the formation of scar tissue http://purl.obolibrary.org/obo/MP_0009393 abnormal resting posture http://purl.obolibrary.org/obo/MP_0001504 abnormal posture atypical intentionally or habitually assumed position of the limbs compared to normal carriage when the body is inactive http://purl.obolibrary.org/obo/MP_0009394 increased uterine NK cell number http://purl.obolibrary.org/obo/MP_0008054 abnormal uterine NK cell morphology increased cell number of a natural killer cell subset that is found in the decidual of the uterus, is CD56-high, Galectin-1-positive and CD16-negative, and is the most abundant immune cell type in the decidual during the first trimester of pregnancy http://purl.obolibrary.org/obo/MP_0009395 increased nucleated erythrocyte cell number http://purl.obolibrary.org/obo/MP_0012397 abnormal nucleated erythrocyte cell number presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells http://purl.obolibrary.org/obo/MP_0009396 small endometrial glands http://purl.obolibrary.org/obo/MP_0009094 abnormal endometrial gland morphology decrease in the average size of the simple or branched tubular glands located in the mucous membrane of the uterus http://purl.obolibrary.org/obo/MP_0009397 increased trophoblast giant cell number http://purl.obolibrary.org/obo/MP_0005033 abnormal trophoblast giant cells greater than normal number of cells of the extraembryonic cell layer that contributes to the placenta http://purl.obolibrary.org/obo/MP_0009398 abnormal skeletal muscle fiber size http://purl.obolibrary.org/obo/MP_0003084 abnormal skeletal muscle fiber morphology anomaly in the size of the large multinucleated cells that make up the skeletal muscles http://purl.obolibrary.org/obo/MP_0009399 increased skeletal muscle fiber size http://purl.obolibrary.org/obo/MP_0009398 abnormal skeletal muscle fiber size increase in the size of the large multinucleated cells that make up the skeletal muscles http://purl.obolibrary.org/obo/MP_0009400 decreased skeletal muscle fiber size http://purl.obolibrary.org/obo/MP_0009398 abnormal skeletal muscle fiber size decrease in the size of the large multinucleated cells that make up the skeletal muscles http://purl.obolibrary.org/obo/MP_0009401 increased skeletal muscle fiber diameter http://purl.obolibrary.org/obo/MP_0009399 increased skeletal muscle fiber size increased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge http://purl.obolibrary.org/obo/MP_0009402 decreased skeletal muscle fiber diameter http://purl.obolibrary.org/obo/MP_0009400 decreased skeletal muscle fiber size decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge http://purl.obolibrary.org/obo/MP_0009403 increased variability of skeletal muscle fiber size http://purl.obolibrary.org/obo/MP_0009398 abnormal skeletal muscle fiber size greater range or dispersion within a distribution of skeletal muscle fiber size within a muscle compared to controls http://purl.obolibrary.org/obo/MP_0009404 centrally nucleated skeletal muscle fibers http://purl.obolibrary.org/obo/MP_0003084 abnormal skeletal muscle fiber morphology cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy http://purl.obolibrary.org/obo/MP_0009405 increased skeletal muscle fiber number http://purl.obolibrary.org/obo/MP_0003084 abnormal skeletal muscle fiber morphology increased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles http://purl.obolibrary.org/obo/MP_0009406 decreased skeletal muscle fiber number http://purl.obolibrary.org/obo/MP_0003084 abnormal skeletal muscle fiber morphology decreased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles http://purl.obolibrary.org/obo/MP_0009407 increased skeletal muscle fiber density http://purl.obolibrary.org/obo/MP_0000759 abnormal skeletal muscle morphology increase in the number of skeletal muscle fibers in a given cross-sectional area of a skeletal muscle http://purl.obolibrary.org/obo/MP_0009408 decreased skeletal muscle fiber density http://purl.obolibrary.org/obo/MP_0000759 abnormal skeletal muscle morphology decrease in the number of skeletal muscle fibers in a given cross-sectional area of a skeletal muscle http://purl.obolibrary.org/obo/MP_0009409 abnormal skeletal muscle fiber type ratio http://purl.obolibrary.org/obo/MP_0000759 abnormal skeletal muscle morphology deviation from the standard ratios of fiber types in a given skeletal muscle compared to control samples http://purl.obolibrary.org/obo/MP_0009410 abnormal skeletal muscle satellite cell proliferation http://purl.obolibrary.org/obo/MP_0002106 abnormal muscle physiology anomaly in the ability of unfused cells in skeltal muscle to undergo expansion by cell division, usually triggered by injury or disease http://purl.obolibrary.org/obo/MP_0009411 abnormal skeletal muscle fiber triad morphology http://purl.obolibrary.org/obo/MP_0003084 abnormal skeletal muscle fiber morphology any structural anomaly of the skeletal muscle fiber structure comprised of the transverse tubule and the two associated terminal cisternae; each fiber normally has thousands of triads http://purl.obolibrary.org/obo/MP_0009412 skeletal muscle fiber degeneration http://purl.obolibrary.org/obo/MP_0009415 skeletal muscle degeneration pathological deterioration of skeletal muscle fiber tissue, often accompanied by loss of function http://purl.obolibrary.org/obo/MP_0009413 skeletal muscle fiber atrophy http://purl.obolibrary.org/obo/MP_0009417 skeletal muscle atrophy acquired diminution of the size of skeletal muscle fibers associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes; occurs with age, immobilization, weightlessness, malnutrition or denervation http://purl.obolibrary.org/obo/MP_0009414 skeletal muscle fiber necrosis http://purl.obolibrary.org/obo/MP_0003852 skeletal muscle necrosis morphological changes resulting from pathological death of skeletal muscle fiber tissue; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0009415 skeletal muscle degeneration http://purl.obolibrary.org/obo/MP_0000759 abnormal skeletal muscle morphology pathological deterioration of skeletal muscle tissue, often accompanied by loss of function http://purl.obolibrary.org/obo/MP_0009416 cardiac muscle degeneration http://purl.obolibrary.org/obo/MP_0010630 abnormal cardiac muscle tissue morphology pathological deterioration of cardiac muscle tissue, often accompanied by loss of function http://purl.obolibrary.org/obo/MP_0009417 skeletal muscle atrophy http://purl.obolibrary.org/obo/MP_0010240 decreased skeletal muscle size acquired diminution of the size of skeletal muscle tissue associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes; occurs with age, immobilization, weightlessness, malnutrition or denervation http://purl.obolibrary.org/obo/MP_0009418 cardiac muscle atrophy http://purl.obolibrary.org/obo/MP_0010630 abnormal cardiac muscle tissue morphology acquired diminution of cardiac muscle tissue associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes; occurs with age, immobilization, weightlessness, malnutrition or denervation http://purl.obolibrary.org/obo/MP_0009420 skeletal muscle endomysial fibrosis http://purl.obolibrary.org/obo/MP_0009419 skeletal muscle fibrosis replacement of the layer of connective tissue that ensheaths a muscle fiber by fibrous tissue resulting in separation of individual fibers http://purl.obolibrary.org/obo/MP_0009421 increased gastrocnemius weight http://purl.obolibrary.org/obo/MP_0013188 abnormal gastrocnemius weight increase in the weight of the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles http://purl.obolibrary.org/obo/MP_0009422 decreased gastrocnemius weight http://purl.obolibrary.org/obo/MP_0013188 abnormal gastrocnemius weight reduction in the weight of the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles http://purl.obolibrary.org/obo/MP_0009423 increased extensor digitorum longus weight http://purl.obolibrary.org/obo/MP_0012783 abnormal extensor digitorum longus weight increase in the weight of the penniform muscle of the lateral front part of the leg responsible for extension of the toes and dorsiflexion of the ankle http://purl.obolibrary.org/obo/MP_0009424 decreased extensor digitorum longus weight http://purl.obolibrary.org/obo/MP_0012783 abnormal extensor digitorum longus weight reduction in the weight of the penniform muscle of the lateral front part of the leg responsible for extension of the toes and dorsiflexion of the ankle http://purl.obolibrary.org/obo/MP_0009425 increased soleus weight http://purl.obolibrary.org/obo/MP_0020165 abnormal soleus weight increase in the weight of the superficial flat broad muscle of the calf that is responsible for plantar flexion of the foot http://purl.obolibrary.org/obo/MP_0009426 decreased soleus weight http://purl.obolibrary.org/obo/MP_0020165 abnormal soleus weight reduction in the weight of the superficial flat broad muscle of the calf that is responsible for plantar flexion of the foot http://purl.obolibrary.org/obo/MP_0009427 increased tibialis anterior weight http://purl.obolibrary.org/obo/MP_0020166 abnormal tibialis anterior weight increase in the weight of the muscle of the shin that is responsible for dorsiflexion and inversion of the foot http://purl.obolibrary.org/obo/MP_0009428 decreased tibialis anterior weight http://purl.obolibrary.org/obo/MP_0020166 abnormal tibialis anterior weight redcution in the weight of the muscle of the shin that is responsible for dorsiflexion and inversion of the foot http://purl.obolibrary.org/obo/MP_0009429 decreased embryo weight http://purl.obolibrary.org/obo/MP_0001698 decreased embryo size reduced weight of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis) http://purl.obolibrary.org/obo/MP_0009430 increased embryo weight http://purl.obolibrary.org/obo/MP_0001699 increased embryo size increase in the weight of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis) http://purl.obolibrary.org/obo/MP_0009431 decreased fetal weight http://purl.obolibrary.org/obo/MP_0004200 decreased fetal size reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth) http://purl.obolibrary.org/obo/MP_0009432 increased fetal weight http://purl.obolibrary.org/obo/MP_0004199 increased fetal size increase in the weight of a fetus compared to controls (sensu Mus: from E14 through birth) http://purl.obolibrary.org/obo/MP_0009433 polyovular ovarian follicle http://purl.obolibrary.org/obo/MP_0001131 abnormal ovarian follicle morphology an ovarian follicle containing more than one oocyte (ovum) http://purl.obolibrary.org/obo/MP_0009434 paraparesis http://purl.obolibrary.org/obo/MP_0000746 weakness a weakness affecting lower or hind limbs http://purl.obolibrary.org/obo/MP_0009435 abnormal miniature inhibitory postsynaptic currents http://purl.obolibrary.org/obo/MP_0002206 abnormal CNS synaptic transmission defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an inhibitory impulse http://purl.obolibrary.org/obo/MP_0009436 fragmentation of sleep/wake states http://purl.obolibrary.org/obo/MP_0001501 abnormal sleep pattern short bouts of sleep/wake stages with an increased number of transitions among these stages compared to controls http://purl.obolibrary.org/obo/MP_0009437 arytenoid and cricoid cartilage fusion http://purl.obolibrary.org/obo/MP_0002258 abnormal cricoid cartilage morphology union of the arytenoid and cricoid cartilages into one structure, when this fusion does not normally occur http://purl.obolibrary.org/obo/MP_0009438 cricoid and tracheal cartilage fusion http://purl.obolibrary.org/obo/MP_0003120 abnormal tracheal cartilage morphology union of the cricoid cartilage and one or more of the tracheal rings into one structure, when this fusion does not normally occur http://purl.obolibrary.org/obo/MP_0009439 increased myeloid sarcoma incidence http://purl.obolibrary.org/obo/MP_0010296 increased hemolymphoid system tumor incidence higher than normal incidence of a malignant tumor of immature myeloid cells, often associated with or preceeding granulocytic leukemia http://purl.obolibrary.org/obo/MP_0009440 increased myeloma incidence http://purl.obolibrary.org/obo/MP_0010296 increased hemolymphoid system tumor incidence higher than normal incidence of a bone marrow cancer in which abnormal plasma cells multiply uncontrollably in the bone marrow and occasionally in other parts of the body http://purl.obolibrary.org/obo/MP_0009441 delayed skin barrier formation http://purl.obolibrary.org/obo/MP_0003941 abnormal skin development slowed progression in the establishment of the ability of the skin to regulate water loss http://purl.obolibrary.org/obo/MP_0009442 increased ovarian teratoma incidence http://purl.obolibrary.org/obo/MP_0008000 increased ovary tumor incidence greater than the expected number of a usually benign tumor found in the ovary, occurring in a specific population in a given time period; ovarian teratomas are typically the result of an anomaly of oogenesis and typically contains a diversity of tissues often representing all organ systems e.g. hair, teeth, bone, thyroid, nerve tissue http://purl.obolibrary.org/obo/MP_0009443 parthenogenesis http://purl.obolibrary.org/obo/MP_0005168 abnormal female meiosis development of an egg into a diploid embryo without being fertilized http://purl.obolibrary.org/obo/MP_0009444 ovarian follicular cyst http://purl.obolibrary.org/obo/MP_0002016 ovary cysts a sac filled with fluid that may develop when the structure containing the egg fails to break open at the time of ovulation http://purl.obolibrary.org/obo/MP_0009445 osteomalacia http://purl.obolibrary.org/obo/MP_0002896 abnormal bone mineralization gradual softening and bending of the bones due to failure of osteoid tissue to calcify as a result of vitamin D deficiency or renal tubular dysfunction http://purl.obolibrary.org/obo/MP_0009446 abnormal platelet dense granule physiology http://purl.obolibrary.org/obo/MP_0005464 abnormal platelet physiology any functional anomaly of the specialized secretory organelles located in the small, irregularly shaped anuclear cells derived from fragmentation of precursor megakaryocytes that contain adenine nucleotides (ADP and ATP), ionized calcium, histamine, serotonin, and epinephrine http://purl.obolibrary.org/obo/MP_0009447 abnormal platelet ATP level http://purl.obolibrary.org/obo/MP_0004721 abnormal platelet dense granule morphology anomaly in the amount of the major energy source adenosine triphosphate produced by dense bodies located in platelets http://purl.obolibrary.org/obo/MP_0009448 decreased platelet ATP level http://purl.obolibrary.org/obo/MP_0009447 abnormal platelet ATP level reduced concentration of the major energy source adenosine triphosphate produced by dense bodies located in platelets http://purl.obolibrary.org/obo/MP_0009449 increased platelet ATP level http://purl.obolibrary.org/obo/MP_0009447 abnormal platelet ATP level increased concentration of the major energy source adenosine triphosphate produced by dense bodies located in platelets http://purl.obolibrary.org/obo/MP_0009450 abnormal axon fasciculation http://purl.obolibrary.org/obo/MP_0009937 abnormal neuron differentiation anomaly in the process by which axons form into nerve fiber bundles http://purl.obolibrary.org/obo/MP_0009451 abnormal chromosome pairing during meiosis http://purl.obolibrary.org/obo/MP_0001930 abnormal meiosis an anomaly in the highly specific side-by-side association of homologous chromosomes during first prophase of meiosis http://purl.obolibrary.org/obo/MP_0009452 abnormal synaptonemal complex http://purl.obolibrary.org/obo/MP_0001930 abnormal meiosis an anomaly in the formation of the proteinaceous structure involved in the pairing of homologous chromosomes during first prophase of meiosis http://purl.obolibrary.org/obo/MP_0009453 enhanced contextual conditioning behavior http://purl.obolibrary.org/obo/MP_0012316 enhanced conditioning behavior increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case) http://purl.obolibrary.org/obo/MP_0009454 impaired contextual conditioning behavior http://purl.obolibrary.org/obo/MP_0012317 impaired conditioning behavior decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case) http://purl.obolibrary.org/obo/MP_0009455 enhanced cued conditioning behavior http://purl.obolibrary.org/obo/MP_0012316 enhanced conditioning behavior increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash) http://purl.obolibrary.org/obo/MP_0009456 impaired cued conditioning behavior http://purl.obolibrary.org/obo/MP_0012317 impaired conditioning behavior decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash) http://purl.obolibrary.org/obo/MP_0009457 whorled hair http://purl.obolibrary.org/obo/MP_0001510 abnormal coat appearance an area of hair growing opposite in direction to the rest of the hair, a curl or swirl http://purl.obolibrary.org/obo/MP_0009459 skeletal muscle hyperplasia http://purl.obolibrary.org/obo/MP_0003398 increased skeletal muscle size overdevelopment or increased size of the skeletal muscle, usually due an increased number of cells http://purl.obolibrary.org/obo/MP_0009460 skeletal muscle hypoplasia http://purl.obolibrary.org/obo/MP_0010240 decreased skeletal muscle size underdevelopment or decreased size of the skeletal muscle, usually due an decreased number of cells http://purl.obolibrary.org/obo/MP_0009461 skeletal muscle hypertrophy http://purl.obolibrary.org/obo/MP_0003398 increased skeletal muscle size increase in the bulk size of the skeletal muscle due to cell enlargement http://purl.obolibrary.org/obo/MP_0009462 skeletal muscle hypotrophy http://purl.obolibrary.org/obo/MP_0010240 decreased skeletal muscle size decrease in the bulk size of the skeletal muscle due to cell shrinkage http://purl.obolibrary.org/obo/MP_0009463 abnormal pituitary infundibular stalk morphology http://purl.obolibrary.org/obo/MP_0004164 abnormal neurohypophysis morphology any structural anomaly of the apical portion of the tubular structure extending from the hypothalamus to the posterior lobe of the pituitary gland http://purl.obolibrary.org/obo/MP_0009465 abnormal gallbladder infundibulum morphology http://purl.obolibrary.org/obo/MP_0005084 abnormal gallbladder morphology any structural anomaly of the tapering portion of the gall bladder that narrows to form the neck and cystic duct http://purl.obolibrary.org/obo/MP_0009466 abnormal uterine tube infundibulum morphology http://purl.obolibrary.org/obo/MP_0003574 abnormal oviduct morphology any structural anomaly of the funnel-like expansion of the abdominal extremity of the uterine tube http://purl.obolibrary.org/obo/MP_0009467 abnormal magnocellular neurosecretory cell morphology http://purl.obolibrary.org/obo/MP_0010913 abnormal neuroendocrine cell morphology any structural anomaly of the cells residing mainly in the hypothalamic supraoptic and paraventricular nuclei and in a number of smaller accessory cell groups between these two nuclei, and secrete the hormones oxytocin and vasopressin http://purl.obolibrary.org/obo/MP_0009468 absent magnocellular neurosecretory cells http://purl.obolibrary.org/obo/MP_0009467 abnormal magnocellular neurosecretory cell morphology absence of the cells residing mainly in the hypothalamic supraoptic and paraventricular nuclei and in a number of smaller accessory cell groups between these two nuclei, and secrete the hormones oxytocin and vasopressin http://purl.obolibrary.org/obo/MP_0009470 mirror image duplication http://purl.obolibrary.org/obo/MP_0002084 abnormal developmental patterning during embryogenesis a second structure develops with its parts arranged in a reversal of right and left orientation http://purl.obolibrary.org/obo/MP_0009471 abnormal urine sulfate level http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis any change in the amount of sulfate in the urine http://purl.obolibrary.org/obo/MP_0009472 increased urine sulfate level http://purl.obolibrary.org/obo/MP_0009471 abnormal urine sulfate level an increase in amount of sulfates in the urine http://purl.obolibrary.org/obo/MP_0009473 abnormal skin exfoliation http://purl.obolibrary.org/obo/MP_0005501 abnormal skin physiology anomaly in the process of detachment and shedding of superficial cells of a skin epithelium http://purl.obolibrary.org/obo/MP_0009474 thick epidermis stratum spinosum http://purl.obolibrary.org/obo/MP_0001236 abnormal epidermis stratum spinosum morphology increased thickness of the stratum spinosum; the polyhedral cell layer http://purl.obolibrary.org/obo/MP_0009475 abnormal nicotine-mediated receptor currents http://purl.obolibrary.org/obo/MP_0002206 abnormal CNS synaptic transmission change in the measured amplitude, current density or duration of response to stimulation of nicotinic receptors http://purl.obolibrary.org/obo/MP_0009476 enlarged cecum http://purl.obolibrary.org/obo/MP_0000494 abnormal cecum morphology increased size of the large sac at the ileum and large intestine junction http://purl.obolibrary.org/obo/MP_0009477 small cecum http://purl.obolibrary.org/obo/MP_0000494 abnormal cecum morphology reduced size of the large sac at the ileum and large intestine junction http://purl.obolibrary.org/obo/MP_0009478 coiled cecum http://purl.obolibrary.org/obo/MP_0000494 abnormal cecum morphology corkscrew or worm-like appearance of the large sac at the ileum and large intestine junction http://purl.obolibrary.org/obo/MP_0009479 abnormal cecum development http://purl.obolibrary.org/obo/MP_0000494 abnormal cecum morphology malformation or aberrant differentiation of the large sac at the ileum and large intestine junction http://purl.obolibrary.org/obo/MP_0009480 distended cecum http://purl.obolibrary.org/obo/MP_0000494 abnormal cecum morphology an expansion in the volume of the large sac at the ileum and large intestine junction, as by stretching or distention http://purl.obolibrary.org/obo/MP_0009481 cecum inflammation http://purl.obolibrary.org/obo/MP_0003304 large intestinal inflammation local accumulation of fluid, plasma proteins, and leukocytes in the cecum http://purl.obolibrary.org/obo/MP_0009482 ileum inflammation http://purl.obolibrary.org/obo/MP_0003306 small intestinal inflammation local accumulation of fluid, plasma proteins, and leukocytes in the ileum http://purl.obolibrary.org/obo/MP_0009483 enlarged ileum http://purl.obolibrary.org/obo/MP_0002581 abnormal ileum morphology increased size of the portion of the small intestine that extends from the jejunum to the colon http://purl.obolibrary.org/obo/MP_0009484 ileum hypertrophy http://purl.obolibrary.org/obo/MP_0009483 enlarged ileum an increase in the bulk size of the portion of the small intestine that extends from the jejunum to the colon due to cell enlargement http://purl.obolibrary.org/obo/MP_0009485 distended ileum http://purl.obolibrary.org/obo/MP_0002581 abnormal ileum morphology an expansion in the volume of the portion of the small intestine that extends from the jejunum to the colon, as by stretching or distention http://purl.obolibrary.org/obo/MP_0009486 rectovaginal fusion http://purl.obolibrary.org/obo/MP_0001139 abnormal vagina morphology fusion of the rectum and vaginal canals http://purl.obolibrary.org/obo/MP_0009487 rectourethral fusion http://purl.obolibrary.org/obo/MP_0000537 abnormal urethra morphology fusion of the rectum and urethral canals http://purl.obolibrary.org/obo/MP_0009488 abnormal pancreatic islet cell apoptosis http://purl.obolibrary.org/obo/MP_0002693 abnormal pancreas physiology change in the timing or the number of pancreatic islet cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0009489 abnormal blood vessel endothelium morphology http://purl.obolibrary.org/obo/MP_0001614 abnormal blood vessel morphology any structural anomaly of the thin layer of flat cells that line the blood vessels and form a barrier between circulating blood in the lumen and the rest of the vessel wall http://purl.obolibrary.org/obo/MP_0009490 abnormal heart left atrium auricular region morphology http://purl.obolibrary.org/obo/MP_0010489 abnormal heart atrium auricular region morphology any structural anomaly of the small conical pouch projections located on the upper anterior portion of the left atrium of the heart http://purl.obolibrary.org/obo/MP_0009491 abnormal heart right atrium auricular region morphology http://purl.obolibrary.org/obo/MP_0010489 abnormal heart atrium auricular region morphology any structural anomaly of the small conical pouch projections located on the upper anterior portion of the right atrium of the heart http://purl.obolibrary.org/obo/MP_0009492 abnormal gallbladder epithelium morphology http://purl.obolibrary.org/obo/MP_0005084 abnormal gallbladder morphology any structural anomaly of the simple columnar epithelial lining of the gall bladder http://purl.obolibrary.org/obo/MP_0009493 abnormal cystic duct morphology http://purl.obolibrary.org/obo/MP_0009498 abnormal extrahepatic bile duct morphology any structural anomaly of the tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct http://purl.obolibrary.org/obo/MP_0009494 abnormal biliary ductule morphology http://purl.obolibrary.org/obo/MP_0009497 abnormal intrahepatic bile duct morphology any structural anomaly of the excretory ducts of the liver that connect the interlobular ductules to the right or left hepatic duct http://purl.obolibrary.org/obo/MP_0009495 abnormal common bile duct morphology http://purl.obolibrary.org/obo/MP_0009498 abnormal extrahepatic bile duct morphology any structural anomaly of the part of the biliary tree formed by the union of the cystic duct and the common hepatic duct http://purl.obolibrary.org/obo/MP_0009496 abnormal common hepatic duct morphology http://purl.obolibrary.org/obo/MP_0009498 abnormal extrahepatic bile duct morphology any structural anomaly of the part of the biliary tree formed by the union of the right and left hepatic ducts, and joins the cystic duct to form the common bile duct http://purl.obolibrary.org/obo/MP_0009497 abnormal intrahepatic bile duct morphology http://purl.obolibrary.org/obo/MP_0002928 abnormal bile duct morphology any structural anomaly of the passages within the liver for the conveyance of bile http://purl.obolibrary.org/obo/MP_0009498 abnormal extrahepatic bile duct morphology http://purl.obolibrary.org/obo/MP_0002928 abnormal bile duct morphology any structural anomaly of the passages external to the liver for the conveyance of bile http://purl.obolibrary.org/obo/MP_0009499 abnormal intralobular bile duct morphology http://purl.obolibrary.org/obo/MP_0009497 abnormal intrahepatic bile duct morphology any structural anomaly of the tubules located between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule http://purl.obolibrary.org/obo/MP_0009500 abnormal interlobular bile duct morphology http://purl.obolibrary.org/obo/MP_0009497 abnormal intrahepatic bile duct morphology any structural anomaly of the canals that carry bile in the liver between the intralobular ducts and the biliary ductules; interlobular bile ducts are part of the interlobular portal triad http://purl.obolibrary.org/obo/MP_0009501 abnormal hepatic duct morphology http://purl.obolibrary.org/obo/MP_0002928 abnormal bile duct morphology any structural anomaly of the two canals (left and right) that collect and drain bile from the left and right half of the liver from the biliary ductules and join external to the liver to form the common hepatic duct http://purl.obolibrary.org/obo/MP_0009502 abnormal areola morphology http://purl.obolibrary.org/obo/MP_0000627 abnormal mammary gland morphology any structural anomaly of the circular pigmented region of the breast that surrounds the nipple and delineates the area containing the areolar glands http://purl.obolibrary.org/obo/MP_0009504 abnormal mammary gland epithelium morphology http://purl.obolibrary.org/obo/MP_0000627 abnormal mammary gland morphology any structural anomaly of the epithelial layer of the luminal surfaces of the mammary gland http://purl.obolibrary.org/obo/MP_0009505 abnormal mammary gland lobule morphology http://purl.obolibrary.org/obo/MP_0000627 abnormal mammary gland morphology any structural anomaly of a group of alveoli and the intralobular portion of the terminal duct of the mammary gland http://purl.obolibrary.org/obo/MP_0009507 abnormal mammary gland connective tissue morphology http://purl.obolibrary.org/obo/MP_0000627 abnormal mammary gland morphology any structural anomaly of the fibrous supportive tissue of the mammary gland http://purl.obolibrary.org/obo/MP_0009508 increased mammary gland ductal carcinoma incidence http://purl.obolibrary.org/obo/MP_0010299 increased mammary gland tumor incidence higher than normal incidence of malignant tumors of the ducts of the mammary gland http://purl.obolibrary.org/obo/MP_0009509 absent rectum http://purl.obolibrary.org/obo/MP_0000492 abnormal rectum morphology absence or loss of the terminal portion of the intestinal tube adjacent to the anus http://purl.obolibrary.org/obo/MP_0009510 cecal atresia http://purl.obolibrary.org/obo/MP_0000494 abnormal cecum morphology congenital blockage or absence of the lumen of the cecum http://purl.obolibrary.org/obo/MP_0009511 distended stomach http://purl.obolibrary.org/obo/MP_0000470 abnormal stomach morphology an expansion in the volume of the sac-like structure of the digestive canal between the esophagus and the small intestine, as by stretching or distention http://purl.obolibrary.org/obo/MP_0009512 abnormal cerebellar Golgi cell morphology http://purl.obolibrary.org/obo/MP_0000886 abnormal cerebellar granule layer morphology any structural anomaly of the population of large inhibitory GABAergic interneurons found in the cerebellar internal granule layer which act by altering the mossy fibre - granule cell synapse; the main synapse made by these cells is a synapse onto the mossy fibre - granule cell excitatory synapse in a glomerulus, which is composed of the mossy fibre terminal, granule cell dendrites, and golgi terminal and is enclosed by a glial coat http://purl.obolibrary.org/obo/MP_0009514 titubation http://purl.obolibrary.org/obo/MP_0001504 abnormal posture posture distinguished by a faltering gait while walking and/or a swaying motion of the trunk or head while resting; often is a characteristic of cellebellar disease http://purl.obolibrary.org/obo/MP_0009515 increased gastrointestinal stromal tumor incidence http://purl.obolibrary.org/obo/MP_0010279 increased gastrointestinal tumor incidence higher than normal incidence of non-epithelial, mesenchymal tumors of the gastrointestinal tract, thought to originate from the interstitial cells of Cajal, the pacemaker cells that regulate peristalsis in the digestive tract; approximately 70% of GISTs develop in the stomach, 20% in the small intestine, and less than 10% in the esophagus, colon, and rectum; GISTs are tumors of connective tissue, i.e. sarcomas, account for 1-3% of all gastrointestinal malignancies in human, and are typically more cellular than other gastrointestinal sarcomas http://purl.obolibrary.org/obo/MP_0009516 enlarged salivary gland http://purl.obolibrary.org/obo/MP_0000613 abnormal salivary gland morphology increased size of the saliva-secreting glands of the oral cavity http://purl.obolibrary.org/obo/MP_0009518 abnormal anterior lingual gland morphology http://purl.obolibrary.org/obo/MP_0003791 abnormal minor salivary gland morphology any structural anomaly of the small glands located near the apex of the tongue on either side of the frenulum http://purl.obolibrary.org/obo/MP_0009519 abnormal anterior buccal gland morphology http://purl.obolibrary.org/obo/MP_0003791 abnormal minor salivary gland morphology any structural anomaly of the racemose, mucous or serous glands in the submucous tissue of the cheeks http://purl.obolibrary.org/obo/MP_0009520 decreased submandibular gland size http://purl.obolibrary.org/obo/MP_0003793 abnormal submandibular gland morphology reduced size of either of the large major salivary glands situated beneath the mandible http://purl.obolibrary.org/obo/MP_0009521 increased submandibular gland size http://purl.obolibrary.org/obo/MP_0003793 abnormal submandibular gland morphology increased size of either of the large major salivary glands situated beneath the mandible http://purl.obolibrary.org/obo/MP_0009522 submandibular gland hypoplasia http://purl.obolibrary.org/obo/MP_0009520 decreased submandibular gland size underdevelopment or reduced size of either of the large major salivary glands situated beneath the mandible, usually due to reduced cell number http://purl.obolibrary.org/obo/MP_0009523 submandibular gland hyperplasia http://purl.obolibrary.org/obo/MP_0009521 increased submandibular gland size overdevelopment or increased size of either of the large major salivary glands situated beneath the mandible, usually due to an increase in the number of cells http://purl.obolibrary.org/obo/MP_0009524 absent submandibular gland http://purl.obolibrary.org/obo/MP_0003793 abnormal submandibular gland morphology absence of either of the large major salivary glands situated beneath the mandible http://purl.obolibrary.org/obo/MP_0009525 abnormal submandibular duct morphology http://purl.obolibrary.org/obo/MP_0009517 abnormal salivary gland duct morphology any structural anomaly of the duct of the submadibular gland that opens at the sublingual papilla near the frenulum of the tongue http://purl.obolibrary.org/obo/MP_0009526 absent sublingual gland http://purl.obolibrary.org/obo/MP_0004035 abnormal sublingual gland morphology absence of the small mucin-producing salivary glands in the floor of the mouth beneath the tongue, anterior to the submandibular gland http://purl.obolibrary.org/obo/MP_0009527 abnormal sublingual duct morphology http://purl.obolibrary.org/obo/MP_0009517 abnormal salivary gland duct morphology any structural anomaly of the canals that drain the sublingual gland http://purl.obolibrary.org/obo/MP_0009528 abnormal major sublingual duct morphology http://purl.obolibrary.org/obo/MP_0009527 abnormal sublingual duct morphology any structural anomaly of the duct that drains the anterior portion of the sublingual gland and opens at the sublingual papilla http://purl.obolibrary.org/obo/MP_0009529 abnormal minor sublingual duct morphology http://purl.obolibrary.org/obo/MP_0009527 abnormal sublingual duct morphology any structural anomaly of the 8-20 small ducts that open into the mouth on the surface of the sublingual fold http://purl.obolibrary.org/obo/MP_0009530 abnormal parotid duct morphology http://purl.obolibrary.org/obo/MP_0009517 abnormal salivary gland duct morphology any structural anomaly of the canal that drains the parotid gland and opens from the cheek into the vestibule of the mouth http://purl.obolibrary.org/obo/MP_0009531 increased parotid gland size http://purl.obolibrary.org/obo/MP_0003452 abnormal parotid gland morphology increased size of either of the largest of the major salivary glands situated below and in front of each ear http://purl.obolibrary.org/obo/MP_0009532 decreased parotid gland size http://purl.obolibrary.org/obo/MP_0003452 abnormal parotid gland morphology reduced size of either of the largest of the major salivary glands situated below and in front of each ear http://purl.obolibrary.org/obo/MP_0009533 absent palatine gland http://purl.obolibrary.org/obo/MP_0000615 abnormal palatine gland morphology absence of the salivary gland of the hard palate http://purl.obolibrary.org/obo/MP_0009534 absent anterior lingual gland http://purl.obolibrary.org/obo/MP_0009518 abnormal anterior lingual gland morphology absence of the small glands located near the apex of the tongue on either side of the frenulum http://purl.obolibrary.org/obo/MP_0009535 abnormal skin sebaceous gland morphology http://purl.obolibrary.org/obo/MP_0001243 abnormal dermal layer morphology any structural anomaly of the holocrine glands of the dermis that secrete sebum into the hair follicles http://purl.obolibrary.org/obo/MP_0009536 abnormal interstitial cell of Cajal morphology http://purl.obolibrary.org/obo/MP_0000462 abnormal digestive system morphology any structural anomaly in the type of cell found in the gastrointestinal tract and serving as a pacemaker that triggers gut contraction; ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumours (GISTs) arise; abnormalities in the ICC network can cause chronic intestinal pseudo-obstruction http://purl.obolibrary.org/obo/MP_0009537 interstitial cells of Cajal hyperplasia http://purl.obolibrary.org/obo/MP_0009536 abnormal interstitial cell of Cajal morphology increased number of the pacemaker cells of the gastrointestinal tract which mediate inputs from the enteric nervous system to smooth muscle cells and trigger gut contraction http://purl.obolibrary.org/obo/MP_0009539 abnormal Hassall's corpuscle morphology http://purl.obolibrary.org/obo/MP_0009544 abnormal thymus epithelium morphology any structural anomaly of the small spherical bodies of epithelial cells found in the medulla of the thymus, that are arranged in a concentric pattern around clusters of degenerating lymphocytes, eosinophils and macrophages http://purl.obolibrary.org/obo/MP_0009540 absent Hassall's corpuscle http://purl.obolibrary.org/obo/MP_0009539 abnormal Hassall's corpuscle morphology absence of the small spherical bodies of epithelial cells found in the medulla of the thymus, that are arranged in a concentric pattern around clusters of degenerating lymphocytes, eosinophils and macrophages http://purl.obolibrary.org/obo/MP_0009541 increased thymocyte apoptosis http://purl.obolibrary.org/obo/MP_0009258 abnormal thymocyte apoptosis increase in the number of immature T cells located in the thymus that are undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0009542 decreased thymocyte apoptosis http://purl.obolibrary.org/obo/MP_0009258 abnormal thymocyte apoptosis reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0009543 abnormal thymus corticomedullary boundary morphology http://purl.obolibrary.org/obo/MP_0002367 abnormal thymus lobule morphology any structural anomaly of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; site of entry of bone marrow stem cells and exit of mature, functional T cells http://purl.obolibrary.org/obo/MP_0009546 absent gastric milk in neonates http://purl.obolibrary.org/obo/MP_0001438 aphagia failure of nursing offspring to ingest milk as indicated by stomach content http://purl.obolibrary.org/obo/MP_0009547 elliptocytosis http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology hematologic disorder in which an abnormally large number of erythrocytes are elliptical rather than the typical biconcave, disc shape http://purl.obolibrary.org/obo/MP_0009548 abnormal platelet aggregation http://purl.obolibrary.org/obo/MP_0006298 abnormal platelet activation any functional anomaly in the adhesion of one platelet to one or more other platelets via adhesion molecules http://purl.obolibrary.org/obo/MP_0009549 decreased platelet aggregation http://purl.obolibrary.org/obo/MP_0009548 abnormal platelet aggregation decrease in the ability of one platelet to one or more other platelets via adhesion molecules http://purl.obolibrary.org/obo/MP_0009550 increased urinary bladder carcinoma incidence http://purl.obolibrary.org/obo/MP_0010289 increased urinary system tumor incidence greater than the expected number of a malignant neoplasm of the urinary bladder, arising from epithelial cells, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0009551 increased urinary bladder transitional cell carcinoma incidence http://purl.obolibrary.org/obo/MP_0009550 increased urinary bladder carcinoma incidence greater than the expected number of a malignant neoplasm of the transitional epithelial layer of the urinary bladder, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0009552 urinary bladder obstruction http://purl.obolibrary.org/obo/MP_0000538 abnormal urinary bladder morphology any impediment or blockage of the musculomembranous elastic bag serving as a storage place for urine http://purl.obolibrary.org/obo/MP_0009553 fused lips http://purl.obolibrary.org/obo/MP_0003769 abnormal lip morphology an anomaly of the fleshy margins of the mouth resulting in the lips being joined together into one structure http://purl.obolibrary.org/obo/MP_0009554 abnormal hair follicle melanin granule shape http://purl.obolibrary.org/obo/MP_0005072 abnormal hair follicle melanin granule morphology the form of pigment polymers in the hair follicle differs compared to controls http://purl.obolibrary.org/obo/MP_0009555 abnormal hair follicle melanin granule distribution http://purl.obolibrary.org/obo/MP_0005072 abnormal hair follicle melanin granule morphology anomaly in the spatial arrangement of particles produced by melanocytes that confer color in the hair follicle http://purl.obolibrary.org/obo/MP_0009556 abnormal platelet ADP level http://purl.obolibrary.org/obo/MP_0004721 abnormal platelet dense granule morphology anomaly in the amount of the major energy source adenosine diphosphate produced by dense bodies located in platelets http://purl.obolibrary.org/obo/MP_0009557 decreased platelet ADP level http://purl.obolibrary.org/obo/MP_0009556 abnormal platelet ADP level reduced concentration of the major energy source adenosine diphosphate produced by dense bodies located in platelets http://purl.obolibrary.org/obo/MP_0009558 increased platelet ADP level http://purl.obolibrary.org/obo/MP_0009556 abnormal platelet ADP level increased concentration of the major energy source adenosine diphosphate produced by dense bodies located in platelets http://purl.obolibrary.org/obo/MP_0009559 thymus cortex hyperplasia http://purl.obolibrary.org/obo/MP_0002371 abnormal thymus cortex morphology overdevelopment or increased size, usually due to an increased cell number, of the outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes http://purl.obolibrary.org/obo/MP_0009560 absent epidermis stratum granulosum http://purl.obolibrary.org/obo/MP_0001239 abnormal epidermis stratum granulosum morphology absence of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis http://purl.obolibrary.org/obo/MP_0009561 superior cervical ganglion degeneration http://purl.obolibrary.org/obo/MP_0001011 abnormal superior cervical ganglion morphology retrogressive pathological change or loss of the largest group of paravertebral ganglia of the sympathetic trunk which normally lies at the base of the skull and innervates the head and neck http://purl.obolibrary.org/obo/MP_0009562 abnormal odor adaptation http://purl.obolibrary.org/obo/MP_0001984 abnormal olfaction altered ability or failure of the olfactory receptor neurons to adapt to ambient conditions by time-dependent modification in the sensitivity to a given odorant stimulus, as seen in the decline of the sensory response during prolonged odor stimulation; a major mechanism for the rapid calcium-calmodulin-mediated desensitization of the CNG channel http://purl.obolibrary.org/obo/MP_0009563 dyskeratosis http://purl.obolibrary.org/obo/MP_0002060 abnormal skin morphology premature keratinization in individual epithelial cells that have not reached the keratinizing surface layer; dyskeratotic cells generally become rounded and they may break away from adjacent cells and fall off http://purl.obolibrary.org/obo/MP_0009564 abnormal meiotic configurations http://purl.obolibrary.org/obo/MP_0001930 abnormal meiosis uncharacteristic chromosome arrangement produced by anomalous chromosome pairing and chiasma formation from prophase to metaphase of meiosis I due to abnormal chromosome structure and necessary to produce functional gametes http://purl.obolibrary.org/obo/MP_0009565 multivalent meiotic configurations http://purl.obolibrary.org/obo/MP_0009564 abnormal meiotic configurations any association of more than two completely or partially homologous chromosomes whose homologous regions are held together by pairing and chiasma formation from prophase to metaphase of meiosis I http://purl.obolibrary.org/obo/MP_0009567 mitotic nondisjuction http://purl.obolibrary.org/obo/MP_0004046 abnormal mitosis failure of sister-chromatids to separate to the cell poles at anaphase http://purl.obolibrary.org/obo/MP_0009568 abnormal red blood cell deformability http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology a measure (DImax) related to cell surface area, of the changeability of the membrane of circulating oxygen transporting cells as a function of physiologically relevant osmolality at a constant applied shear stress http://purl.obolibrary.org/obo/MP_0009571 abnormal right lung accessory lobe morphology http://purl.obolibrary.org/obo/MP_0010975 abnormal lung lobe morphology any structural anomaly of the right lung lobe which lies against the diaphragm and has a considerable volume residing in the left hemi-thorax http://purl.obolibrary.org/obo/MP_0009575 abnormal pubic symphysis morphology http://purl.obolibrary.org/obo/MP_0004506 abnormal pubis morphology any structural anomaly of the firm fibrocartilaginous joint in the median plane between the two opposing surfaces of the pubic bones, which are united by an interpubic disc of fibrocartilage as well as the superior and arcuate pubic ligaments http://purl.obolibrary.org/obo/MP_0009576 oral atresia http://purl.obolibrary.org/obo/MP_0000452 abnormal mouth morphology congenital blockage, fusion, or absence of the normal opening of the oral cavity http://purl.obolibrary.org/obo/MP_0009578 otocephaly http://purl.obolibrary.org/obo/MP_0011495 abnormal head shape a structural anomaly of the head consisting of absence or malformation of the lower jaw and the ears united or closely approaching below the face http://purl.obolibrary.org/obo/MP_0009579 acephaly http://purl.obolibrary.org/obo/MP_0000432 abnormal head morphology congenital absence of the head http://purl.obolibrary.org/obo/MP_0009580 increased keratinocyte apoptosis http://purl.obolibrary.org/obo/MP_0006042 increased apoptosis increase in the number of keratinocytes undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0009581 decreased keratinocyte apoptosis http://purl.obolibrary.org/obo/MP_0006043 decreased apoptosis reduction in the number of keratinocytes undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0009582 abnormal keratinocyte proliferation http://purl.obolibrary.org/obo/MP_0003453 abnormal keratinocyte physiology anomaly in the ability of keratinocytes to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0009583 increased keratinocyte proliferation http://purl.obolibrary.org/obo/MP_0009582 abnormal keratinocyte proliferation increase in the expansion rate of keratinocytes by cell division http://purl.obolibrary.org/obo/MP_0009584 decreased keratinocyte proliferation http://purl.obolibrary.org/obo/MP_0009582 abnormal keratinocyte proliferation reduction in the expansion rate of keratinocytes by cell division http://purl.obolibrary.org/obo/MP_0009585 ectopic bone formation http://purl.obolibrary.org/obo/MP_0008271 abnormal bone ossification formation of bone at an abnormal site or in an atypical tissue, usually outside its normal location http://purl.obolibrary.org/obo/MP_0009586 increased platelet aggregation http://purl.obolibrary.org/obo/MP_0009548 abnormal platelet aggregation increase in the ability of one platelet to one or more other platelets via adhesion molecules http://purl.obolibrary.org/obo/MP_0009587 abnormal plasma membrane sphingolipid content http://purl.obolibrary.org/obo/MP_0003950 abnormal plasma membrane morphology altered amounts of the phospholipids found especially in, but not limited to, the cell membrane of nerve tissue that yield sphingosine, choline, a fatty acid, and phosphoric acid upon hydrolysis http://purl.obolibrary.org/obo/MP_0009588 increased plasma membrane sphingolipid content http://purl.obolibrary.org/obo/MP_0009587 abnormal plasma membrane sphingolipid content abnormal accumulation of the phospolipids found especially in, but not limited to, the cell membrane of nerve tissue that yield sphingosine, choline, a fatty acid, and phosphoric acid upon hydrolysis http://purl.obolibrary.org/obo/MP_0009589 sphingomyelinosis http://purl.obolibrary.org/obo/MP_0009823 abnormal sphingomyelin level the abnormal accumulation of sphingomyelin in the plasma membrane of cells of the nervous tissue, liver and spleen, usually due to sphingomyelinase deficiency http://purl.obolibrary.org/obo/MP_0009590 increased gonad tumor incidence http://purl.obolibrary.org/obo/MP_0010287 increased reproductive system tumor incidence greater than the expected number of an abnormal rapidly proliferating cells in the testis or ovary, usually in the form of a distinct mass, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0009591 increased liver adenocarcinoma incidence http://purl.obolibrary.org/obo/MP_0009308 increased adenocarcinoma incidence greater than the expected number of a malignant neoplasm of epithelial cells in the liver, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0009592 increased Leydig cell tumor incidence http://purl.obolibrary.org/obo/MP_0006262 increased testis tumor incidence greater than the expected number of rare testicular tumors of the male gonadal interstitium, occurring in a specific population in a given time period; Leydig cell tumors are frequently hormonally active, leading to feminizing or virilizing syndromes; Leydig cell tumors comprise 1-3% of all testicular neoplasms, can be pure or mixed with other sex cord-stromal or germ cell tumors, and are usually benign, although malignant variants also occur http://purl.obolibrary.org/obo/MP_0009593 absent chorion http://purl.obolibrary.org/obo/MP_0002836 abnormal chorion morphology absence of the outermost extraembryonic membrane http://purl.obolibrary.org/obo/MP_0009594 abnormal corneocyte envelope morphology http://purl.obolibrary.org/obo/MP_0001240 abnormal epidermis stratum corneum morphology any structural anomaly of the electron-dense layer of highly transglutaminase cross-linked protein that is deposited on the inner surface of the plasma membrane of corneocytes in the outermost layers of the epidermis; a monomolecular layer of ceramides is covalently attached to the outer surface of the CE to form a hydrophobic lipid envelope that covers each corneocyte and provides continuity with the lipid matrix http://purl.obolibrary.org/obo/MP_0009595 enlarged corneocyte envelope http://purl.obolibrary.org/obo/MP_0009594 abnormal corneocyte envelope morphology increased size of the electron-dense layer of highly transglutaminase cross-linked protein that is deposited on the inner surface of the plasma membrane of corneocytes in the outermost layers of the epidermis http://purl.obolibrary.org/obo/MP_0009596 abnormal stratum corneum lipid matrix formation http://purl.obolibrary.org/obo/MP_0001240 abnormal epidermis stratum corneum morphology altered lipid composition or intercellular lipid matrix assembly in the stratum corneum, usually resulting in loss of epidermal barrier function; normally, the intercorneocyte lipid matrix consists of a complex lipid mixture of ceramides, cholesterol and long-chain saturated fatty acids that self-assembles into an ordered multilayer structure known as lipid lamellae http://purl.obolibrary.org/obo/MP_0009597 impaired stratum corneum desquamation http://purl.obolibrary.org/obo/MP_0001240 abnormal epidermis stratum corneum morphology dysregulated shedding of the outermost layer of corneocytes, affecting the integrity and thickness of the stratum corneum; may result in xerotic and ichthyotic conditions http://purl.obolibrary.org/obo/MP_0009598 thin epidermis stratum granulosum http://purl.obolibrary.org/obo/MP_0001239 abnormal epidermis stratum granulosum morphology decreased thickness of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis http://purl.obolibrary.org/obo/MP_0009599 thick epidermis stratum granulosum http://purl.obolibrary.org/obo/MP_0001239 abnormal epidermis stratum granulosum morphology increased thickness of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis http://purl.obolibrary.org/obo/MP_0009600 hypergranulosis http://purl.obolibrary.org/obo/MP_0009599 thick epidermis stratum granulosum increased thickness of the granular layer of the epidermis http://purl.obolibrary.org/obo/MP_0009601 epidermis stratum granulosum hyperplasia http://purl.obolibrary.org/obo/MP_0001239 abnormal epidermis stratum granulosum morphology overdevelopment or increased size, usually due an increased number of cells, of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis http://purl.obolibrary.org/obo/MP_0009602 abnormal keratohyalin granule morphology http://purl.obolibrary.org/obo/MP_0001239 abnormal epidermis stratum granulosum morphology any structural anomaly of the irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis that may play a role in keratinization and barrier function http://purl.obolibrary.org/obo/MP_0009603 absent keratohyalin granules http://purl.obolibrary.org/obo/MP_0009605 decreased keratohyalin granule number absence of the irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis that may play a role in keratinization and barrier function http://purl.obolibrary.org/obo/MP_0009604 increased keratohyalin granule number http://purl.obolibrary.org/obo/MP_0009602 abnormal keratohyalin granule morphology increased number of the irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis that may play a role in keratinization and barrier function http://purl.obolibrary.org/obo/MP_0009605 decreased keratohyalin granule number http://purl.obolibrary.org/obo/MP_0009602 abnormal keratohyalin granule morphology reduced number of the irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis that may play a role in keratinization and barrier function http://purl.obolibrary.org/obo/MP_0009606 increased keratohyalin granule size http://purl.obolibrary.org/obo/MP_0009602 abnormal keratohyalin granule morphology increased size of the irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis that may play a role in keratinization and barrier function http://purl.obolibrary.org/obo/MP_0009607 decreased keratohyalin granule size http://purl.obolibrary.org/obo/MP_0009602 abnormal keratohyalin granule morphology reduced size of the irregularly shaped basophilic granules in the cells of the stratum granulosum of the epidermis that may play a role in keratinization and barrier function http://purl.obolibrary.org/obo/MP_0009608 abnormal epidermal lamellar body morphology http://purl.obolibrary.org/obo/MP_0001239 abnormal epidermis stratum granulosum morphology any structural anomaly of a membrane-bounded organelle present in the epidermis, specialized for the storage and secretion of various substances (such as glycoproteins and acid phosphates), and which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae http://purl.obolibrary.org/obo/MP_0009609 absent basioccipital bone http://purl.obolibrary.org/obo/MP_0000079 abnormal basioccipital bone morphology absence of the basilar process of the occipital bone in the base of the cranium, frequently forming a direct part of the occipital in the adult, but usually distinct in the young http://purl.obolibrary.org/obo/MP_0009610 abnormal epidermis stratum lucidum morphology http://purl.obolibrary.org/obo/MP_0001216 abnormal epidermal layer morphology any structural anomaly of the layer of lightly staining corneocytes foud between the stratum granulosum and stratum corneum layers; found primarily in the thick epidermis of the palmar and plantar skin and is composed of three to five layers of dead, flattened keratinocytes http://purl.obolibrary.org/obo/MP_0009612 thick epidermis suprabasal layer http://purl.obolibrary.org/obo/MP_0001233 abnormal epidermis suprabasal layer morphology increased thickness of the suprabasal layer of the epidermis http://purl.obolibrary.org/obo/MP_0009613 thin epidermis suprabasal layer http://purl.obolibrary.org/obo/MP_0001233 abnormal epidermis suprabasal layer morphology decreased thickness of the suprabasal layer of the epidermis http://purl.obolibrary.org/obo/MP_0009614 absent epidermis stratum spinosum http://purl.obolibrary.org/obo/MP_0001236 abnormal epidermis stratum spinosum morphology absence of the layer of polyhedral cells in the epidermis; shrinkage and adhesion of these cells gives a spiny or prickly appearance http://purl.obolibrary.org/obo/MP_0009615 abnormal zinc homeostasis http://purl.obolibrary.org/obo/MP_0005636 abnormal mineral homeostasis anomaly in the processes involved in the maintenance of an internal equilibrium of zinc that normally is a cofactor in many proteins http://purl.obolibrary.org/obo/MP_0009616 abnormal brain zinc level http://purl.obolibrary.org/obo/MP_0009615 abnormal zinc homeostasis any anomaly in the amount of zinc present in mammalian brain tissue, where 5-15 percent of total zinc is concentrated in synaptic vesicles in a subset of glutamatergic neurons; histochemically reactive zinc is present in many regions of the central nervous system and is especially abundant in the hippocampus http://purl.obolibrary.org/obo/MP_0009617 decreased brain zinc level http://purl.obolibrary.org/obo/MP_0009616 abnormal brain zinc level reduction in the amount of zinc present in the brain tissue http://purl.obolibrary.org/obo/MP_0009618 increased brain zinc level http://purl.obolibrary.org/obo/MP_0009616 abnormal brain zinc level increase in the amount of zinc present in the brain tissue http://purl.obolibrary.org/obo/MP_0009619 abnormal optokinetic reflex http://purl.obolibrary.org/obo/MP_0001961 abnormal reflex any anomaly in the nystagmus or deviation of the eyes in response to stimulation of the visual system by movement; normally, this reflex functions to stabilize a moving image on the retina http://purl.obolibrary.org/obo/MP_0009620 abnormal primary vitreous morphology http://purl.obolibrary.org/obo/MP_0002699 abnormal vitreous body morphology any structural anomaly in the fibrovascular mesodermal tissue located between the optic cup and lens vesicle that normally regresses during the development of the vitreous body http://purl.obolibrary.org/obo/MP_0009621 primary vitreous hyperplasia http://purl.obolibrary.org/obo/MP_0009620 abnormal primary vitreous morphology overdevelopment or increased size of the primary vitreous, usually due an increased number of cells http://purl.obolibrary.org/obo/MP_0009622 absent inguinal lymph nodes http://purl.obolibrary.org/obo/MP_0002353 abnormal inguinal lymph node morphology absence of the lymph nodes normally located in the groin area http://purl.obolibrary.org/obo/MP_0009623 enlarged inguinal lymph nodes http://purl.obolibrary.org/obo/MP_0002353 abnormal inguinal lymph node morphology increased size of the lymph nodes located in the groin area http://purl.obolibrary.org/obo/MP_0009624 small inguinal lymph nodes http://purl.obolibrary.org/obo/MP_0002353 abnormal inguinal lymph node morphology reduced size of the lymph nodes located in the groin area http://purl.obolibrary.org/obo/MP_0009625 abnormal abdominal lymph node morphology http://purl.obolibrary.org/obo/MP_0002339 abnormal lymph node morphology any structural anomaly of the visceral glands that are located in the abdomen http://purl.obolibrary.org/obo/MP_0009626 abnormal celiac lymph node morphology http://purl.obolibrary.org/obo/MP_0009625 abnormal abdominal lymph node morphology any structural anomaly of the visceral glands that are associated with the branches of the celiac artery, including the gastric, hepatic, and pancreaticolienal (splenic) lymph nodes http://purl.obolibrary.org/obo/MP_0009628 absent brachial lymph nodes http://purl.obolibrary.org/obo/MP_0005231 abnormal brachial lymph node morphology absence of the lymph nodes located along the brachial vein that receive drainage from most of the free upper limb and send efferent vessels to the central axillary lymph nodes http://purl.obolibrary.org/obo/MP_0009629 small brachial lymph nodes http://purl.obolibrary.org/obo/MP_0005231 abnormal brachial lymph node morphology reduced size of the lymph nodes located along the brachial vein that receive drainage from most of the free upper limb and send efferent vessels to the central axillary lymph nodes http://purl.obolibrary.org/obo/MP_0009630 absent axillary lymph nodes http://purl.obolibrary.org/obo/MP_0002340 abnormal axillary lymph node morphology absence of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region http://purl.obolibrary.org/obo/MP_0009631 enlarged axillary lymph nodes http://purl.obolibrary.org/obo/MP_0002340 abnormal axillary lymph node morphology increased size of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region http://purl.obolibrary.org/obo/MP_0009632 small axillary lymph nodes http://purl.obolibrary.org/obo/MP_0002340 abnormal axillary lymph node morphology reduced size of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region http://purl.obolibrary.org/obo/MP_0009633 absent cervical lymph nodes http://purl.obolibrary.org/obo/MP_0002351 abnormal cervical lymph node morphology absence of the lymph nodes normally found near the neck and shoulders http://purl.obolibrary.org/obo/MP_0009634 absent popliteal lymph nodes http://purl.obolibrary.org/obo/MP_0002352 abnormal popliteal lymph node morphology absence of the lymph nodes which drain the legs http://purl.obolibrary.org/obo/MP_0009635 enlarged popliteal lymph nodes http://purl.obolibrary.org/obo/MP_0002352 abnormal popliteal lymph node morphology increased size of the lymph nodes which drain the legs http://purl.obolibrary.org/obo/MP_0009636 small popliteal lymph nodes http://purl.obolibrary.org/obo/MP_0002352 abnormal popliteal lymph node morphology reduced size of the lymph nodes which drain the legs http://purl.obolibrary.org/obo/MP_0009637 abnormal pretectal region morphology http://purl.obolibrary.org/obo/MP_0000897 abnormal midbrain morphology any structural anomaly of a narrow, transversely oriented rostral zone of the mesencephalic tectum, bounded caudally by the superior colliculus, rostrally by the habenular trigone, and laterally by the pulvinar thalami; the pretectal area contains several nuclei that receive fibers from the optic tract; it has bilateral efferent connections with the Edinger-Westphal nucleus of the oculomotor nuclear complex by way of which it mediates the pupillary light reflex http://purl.obolibrary.org/obo/MP_0009638 abnormal pretectal nuclei morphology http://purl.obolibrary.org/obo/MP_0009637 abnormal pretectal region morphology any structural anomaly of the groups of neurons located between the thalamus and midbrain that receive binocular sensory input from retinal ganglion cells of the eyes and are responsible for maintaining the pupillary light reflex http://purl.obolibrary.org/obo/MP_0009639 abnormal olivary pretectal nucleus morphology http://purl.obolibrary.org/obo/MP_0009638 abnormal pretectal nuclei morphology any structural anomaly of one of several pretectal nuclei with direct input from the eye and the only one containing neurons whose rate of firing is linearly related to the intensity of light falling on the retina http://purl.obolibrary.org/obo/MP_0009640 abnormal renal tubule epithelium morphology http://purl.obolibrary.org/obo/MP_0004967 abnormal kidney epithelium morphology any structural anomaly of the cellular avascular layer of the renal tubule luminar surfaces http://purl.obolibrary.org/obo/MP_0009644 uremia http://purl.obolibrary.org/obo/MP_0009642 abnormal blood homeostasis an excess of urea, creatinine, and other nitrogenous end products of protein and amino acid metabolism in the blood; usually indicative of kidney dysfunction http://purl.obolibrary.org/obo/MP_0009645 crystalluria http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis excretion of crystalline material in the urine http://purl.obolibrary.org/obo/MP_0009646 urinary bladder inflammation http://purl.obolibrary.org/obo/MP_0011762 renal/urinary system inflammation local accumulation of fluid, plasma proteins, and leukocytes in the urinary bladder http://purl.obolibrary.org/obo/MP_0009647 decreased fertilization frequency http://purl.obolibrary.org/obo/MP_0005410 abnormal fertilization the number of secondary oocytes each penetrated by a spermatozoon followed by fusion of the male and female pronuclei are fewer than expected http://purl.obolibrary.org/obo/MP_0009648 abnormal superovulation http://purl.obolibrary.org/obo/MP_0001928 abnormal ovulation altered ability of a female to be induced to ovulate an expected number of ova after treatment with specific gonadotrophic hormones http://purl.obolibrary.org/obo/MP_0009649 delayed embryo implantation http://purl.obolibrary.org/obo/MP_0001727 abnormal embryo implantation any lag in the normal time course necessary for the attachment of the blastocyst to the endometrium http://purl.obolibrary.org/obo/MP_0009650 dormant blastocysts http://purl.obolibrary.org/obo/MP_0001727 abnormal embryo implantation blastocysts sometimes larger than normal in size, showing no development or mitotic activity as a result of delayed implantation http://purl.obolibrary.org/obo/MP_0009651 abnormal eyelid development http://purl.obolibrary.org/obo/MP_0001340 abnormal eyelid morphology aberrant formation of the skin folds covering the front of the eyeball http://purl.obolibrary.org/obo/MP_0009652 abnormal palatal rugae morphology http://purl.obolibrary.org/obo/MP_0003756 abnormal hard palate morphology any structural anomaly in the transversal ridges that develop on the secondary (hard) palate http://purl.obolibrary.org/obo/MP_0009653 abnormal palate development http://purl.obolibrary.org/obo/MP_0003935 abnormal craniofacial development abnormal formation of the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate) http://purl.obolibrary.org/obo/MP_0009654 abnormal primary palate development http://purl.obolibrary.org/obo/MP_0009653 abnormal palate development any anomaly in the formation of the part of the shelf separating the oral and nasal cavities that is formed during early embryonic development from the medial nasal processes which derive from the frontonasal process; these merge with each other and with the bilateral maxillary processes to form the upper lip and the primary palate http://purl.obolibrary.org/obo/MP_0009655 abnormal secondary palate development http://purl.obolibrary.org/obo/MP_0009653 abnormal palate development any anomaly in the formation of the part of the palate that is formed during embryonic development when palatal projections from the inner part of the maxillary processes emerge, extend and elevate into a horizontal position above the tongue http://purl.obolibrary.org/obo/MP_0009656 delayed chorioallantoic fusion http://purl.obolibrary.org/obo/MP_0002824 abnormal chorioallantoic fusion late onset of the initiation and/or completion of the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois http://purl.obolibrary.org/obo/MP_0009657 failure of chorioallantoic fusion http://purl.obolibrary.org/obo/MP_0002824 abnormal chorioallantoic fusion failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois http://purl.obolibrary.org/obo/MP_0009658 increased placenta apoptosis http://purl.obolibrary.org/obo/MP_0010038 abnormal placenta physiology increase in the number of cells of the placenta undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0009659 striated fur http://purl.obolibrary.org/obo/MP_0001510 abnormal coat appearance hair or fur characterized by transverse, usually parallel, markings due to an anomaly in hair color, texture, or growth http://purl.obolibrary.org/obo/MP_0009660 abnormal induced retinal neovascularization http://purl.obolibrary.org/obo/MP_0008852 retinal neovascularization any anomaly in the response to conditions which induce the pathological growth of vessels into the retina http://purl.obolibrary.org/obo/MP_0009662 abnormal uterine receptivity http://purl.obolibrary.org/obo/MP_0004014 abnormal uterine environment any alteration in the time sensitive process of uterine differentiation that occurs in response to implantation competent blastocysts and precedes and is necessary for embryo implantation http://purl.obolibrary.org/obo/MP_0009663 abnormal uterine-embryonic axis http://purl.obolibrary.org/obo/MP_0009669 abnormal postimplantation uterine environment any anomaly in the process whereby the implantation chamber orients in the uterus in response to decidual growth to insure correct alignment of the embryo to the uterus http://purl.obolibrary.org/obo/MP_0009664 abnormal luminal closure http://purl.obolibrary.org/obo/MP_0004014 abnormal uterine environment an anomaly in the degree to which (for each species) the uterine epithelium closes over and makes contact with, and secures an implanting blastocyst http://purl.obolibrary.org/obo/MP_0009665 abnormal embryo apposition http://purl.obolibrary.org/obo/MP_0001727 abnormal embryo implantation any anomaly that prevents the initial positioning of the blastocyst trophoblast and uterine luminal epithelium causing the blastocyst to fail to orientate correctly along the uterine wall http://purl.obolibrary.org/obo/MP_0009666 abnormal embryo attachment http://purl.obolibrary.org/obo/MP_0001727 abnormal embryo implantation any anomaly in the process whereby the blastocyst anchors to the uterine luminal epithelium and cannot be dislodged by flushing http://purl.obolibrary.org/obo/MP_0009667 abnormal embryo invasion http://purl.obolibrary.org/obo/MP_0001727 abnormal embryo implantation any anomaly in the process that enables the embryo to establish connection to the uterine luminal epithelium http://purl.obolibrary.org/obo/MP_0009668 ectopic pregnancy http://purl.obolibrary.org/obo/MP_0009661 abnormal pregnancy a fertilized egg attaches and begins development in a location other than in the inner lining of the uterus, most commonly in the Fallopian tube http://purl.obolibrary.org/obo/MP_0009669 abnormal postimplantation uterine environment http://purl.obolibrary.org/obo/MP_0009671 abnormal uterus physiology failure of the uterus to undergo the changes necessary to support pregnancy following implantation of the embryo http://purl.obolibrary.org/obo/MP_0009670 abnormal uterine angiogenesis http://purl.obolibrary.org/obo/MP_0009669 abnormal postimplantation uterine environment any anomaly in vascular permeability and blood vessel development that normally occurs in the uterus to support embryonic growth during pregnancy http://purl.obolibrary.org/obo/MP_0009671 abnormal uterus physiology http://purl.obolibrary.org/obo/MP_0003699 abnormal female reproductive system physiology any functional anomaly of the female muscular organ of gestation in which the developing embryo or fetus is nourished until birth http://purl.obolibrary.org/obo/MP_0009672 abnormal birth weight http://purl.obolibrary.org/obo/MP_0009701 abnormal birth body size anomaly in average weight at birth compared to controls http://purl.obolibrary.org/obo/MP_0009673 increased birth weight http://purl.obolibrary.org/obo/MP_0009702 increased birth body size increase in average weight at birth compared to controls http://purl.obolibrary.org/obo/MP_0009674 decreased birth weight http://purl.obolibrary.org/obo/MP_0009703 decreased birth body size reduction in average weight at birth compared to controls http://purl.obolibrary.org/obo/MP_0009675 orthokeratosis http://purl.obolibrary.org/obo/MP_0001242 hyperkeratosis thickening of the stratum corneum of the epidermis (hyperkeratosis) with non-nucleated keratinocytes retained in this layer http://purl.obolibrary.org/obo/MP_0009677 abnormal spinal cord dorsal column morphology http://purl.obolibrary.org/obo/MP_0008027 abnormal spinal cord white matter morphology any structural anomaly of the wedge-shaped fiber bundle of white matter in the dorsomedial side of the spinal cord that is made up of the fasciculus gracilis and fasciculus cuneatus; it is part of the ascending posterior column-medial lemniscus pathway that is important for well-localized fine touch and conscious proprioception http://purl.obolibrary.org/obo/MP_0009678 abnormal spinal cord lateral column morphology http://purl.obolibrary.org/obo/MP_0008027 abnormal spinal cord white matter morphology any structural anomaly of the region of white matter of the spinal cord that is located between the dorsal and ventral spinal roots http://purl.obolibrary.org/obo/MP_0009679 abnormal spinal cord ventral column morphology http://purl.obolibrary.org/obo/MP_0008027 abnormal spinal cord white matter morphology any structural anomaly of the area of white matter of the spinal cord located on either side of the ventral (anterior) medial fissure http://purl.obolibrary.org/obo/MP_0009680 abnormal medulla oblongata anterior median fissure morphology http://purl.obolibrary.org/obo/MP_0000846 abnormal medulla oblongata morphology any structural anomaly of the longitudinal groove in the midline of the anterior aspect of the medulla oblongata http://purl.obolibrary.org/obo/MP_0009681 abnormal pyramidal decussation morphology http://purl.obolibrary.org/obo/MP_0009680 abnormal medulla oblongata anterior median fissure morphology any structural anomaly of the bundles of pyramidal fibers that intercross obliquely over the midline at the lower border region of the medulla oblongata http://purl.obolibrary.org/obo/MP_0009682 abnormal anterior corticospinal tract morphology http://purl.obolibrary.org/obo/MP_0000778 abnormal nervous system tract morphology any structural anomaly of the small bundle of corticospinal motor fibers that do not cross the midline at the pyramidal decussation and descend into the anterior funiculus of the spinal cord; the anterior corticospinal tract controls central axial and girdle muscles http://purl.obolibrary.org/obo/MP_0009683 abnormal lateral corticospinal tract morphology http://purl.obolibrary.org/obo/MP_0000778 abnormal nervous system tract morphology any structural anomaly of the large bundle of corticospinal motor fibers that cross the midline at the pyramidal decussation and descend in the dorsal half of the lateral funiculus; the lateral corticospinal tract controls movement of contralateral limbs http://purl.obolibrary.org/obo/MP_0009684 abnormal spinal cord lateral motor column morphology http://purl.obolibrary.org/obo/MP_0009685 abnormal spinal cord motor column morphology any structural anomaly of the subclasses of motor neurons which innervate muscles in the limb; motor neurons in the lateral motor column are further organized into pools, each of which innervates a specific muscle in the limb http://purl.obolibrary.org/obo/MP_0009685 abnormal spinal cord motor column morphology http://purl.obolibrary.org/obo/MP_0000955 abnormal spinal cord morphology any structural anomaly of the subclasses of motor neurons which are organized into longitudinally oriented columns that occupy distinct and, in some cases, discontinuous domains along the rostrocaudal axis of the spinal cord; motor neurons within a single column send their axons to a common peripheral target http://purl.obolibrary.org/obo/MP_0009686 abnormal spinal cord medial motor column morphology http://purl.obolibrary.org/obo/MP_0009685 abnormal spinal cord motor column morphology any structural anomaly of the subclasses of motor neurons which project their axons to axial muscles that lie close to the vertebral column; motor neurons in the lateral subdivision of the MMC project their axons to body wall muscles http://purl.obolibrary.org/obo/MP_0009687 empty decidua capsularis http://purl.obolibrary.org/obo/MP_0001727 abnormal embryo implantation the implanted embryo normally covered opposite the placenta by uterine mucosa and epithelium following implantation is missing, suggesting the embryo died early during implantation but after the decidual response and modification of uterine stromal cells http://purl.obolibrary.org/obo/MP_0009688 abnormal spinal cord central canal morphology http://purl.obolibrary.org/obo/MP_0000955 abnormal spinal cord morphology any structural anomaly of the ependyma-lined lumen of the spinal cord that is filled with cerebrospinal fluid; it is patent with the ventricular system of the brain and frequently becomes occluded in aging adults http://purl.obolibrary.org/obo/MP_0009689 abnormal neural tube ventricular layer morphology http://purl.obolibrary.org/obo/MP_0002151 abnormal neural tube morphology/development any structural anomaly of the layer of undifferentiated, proliferating cells that line the neural tube lumen http://purl.obolibrary.org/obo/MP_0009690 abnormal neural tube mantle layer morphology http://purl.obolibrary.org/obo/MP_0002151 abnormal neural tube morphology/development any structural anomaly of the layer of glia and differentiating neurons that will form the gray matter of the spinal cord; this lies between the ventricular and marginal layers and includes the basal and alar plates http://purl.obolibrary.org/obo/MP_0009691 abnormal neural tube marginal layer morphology http://purl.obolibrary.org/obo/MP_0002151 abnormal neural tube morphology/development any structural anomaly of the outermost layer of the neural tube that contains nerve fibers and will form the white matter http://purl.obolibrary.org/obo/MP_0009692 abnormal spinal cord alar plate morphology http://purl.obolibrary.org/obo/MP_0009690 abnormal neural tube mantle layer morphology any structural anomaly of the region of the mantle layer of the neural tube that lies dorsal to the sulcus limitans and contains primarily sensory neurons and interneurons involved in communication of sensory impulses; the alar plate develops into the dorsal horn in the grey matter of the spinal cord http://purl.obolibrary.org/obo/MP_0009693 abnormal spinal cord basal plate morphology http://purl.obolibrary.org/obo/MP_0009690 abnormal neural tube mantle layer morphology any structural anomaly of the region of the mantle layer of the neural tube that lies ventral to the sulcus limitans and contains primarily motor neurons and interneurons http://purl.obolibrary.org/obo/MP_0009694 abnormal spinal cord commissure morphology http://purl.obolibrary.org/obo/MP_0000955 abnormal spinal cord morphology any structural anomaly of any of the nerve fiber tracts that span the midline of the spinal cord http://purl.obolibrary.org/obo/MP_0009695 abnormal spinal cord ventral commissure morphology http://purl.obolibrary.org/obo/MP_0009694 abnormal spinal cord commissure morphology any structural anomaly of the band of nerve fibers which cross the midline of the spinal cord ventral to the central canal and posterior grey commissure http://purl.obolibrary.org/obo/MP_0009696 abnormal spinal cord grey commissure morphology http://purl.obolibrary.org/obo/MP_0009694 abnormal spinal cord commissure morphology any structural anomaly of the band of grey substance spanning the midline of the spinal cord that surrounds the central canal http://purl.obolibrary.org/obo/MP_0009698 heart hemorrhage http://purl.obolibrary.org/obo/MP_0001634 internal hemorrhage bleeding into the heart http://purl.obolibrary.org/obo/MP_0009699 hyperchylomicronemia http://purl.obolibrary.org/obo/MP_0010330 abnormal circulating lipoprotein level increased plasma concentrations of chylomicrons, the large lipid droplet (up to 100 mm in diameter) of reprocessed lipid synthesized in epithelial cells of the small intestine and containing triacylglycerols, cholesterol esters, and several apolipoproteins http://purl.obolibrary.org/obo/MP_0009701 abnormal birth body size http://purl.obolibrary.org/obo/MP_0005378 growth/size/body phenotype anomaly in average body size at birth compared to controls http://purl.obolibrary.org/obo/MP_0009702 increased birth body size http://purl.obolibrary.org/obo/MP_0009701 abnormal birth body size increase in average body size at birth compared to controls http://purl.obolibrary.org/obo/MP_0009703 decreased birth body size http://purl.obolibrary.org/obo/MP_0009701 abnormal birth body size reduction in average body size at birth compared to controls http://purl.obolibrary.org/obo/MP_0009704 increased skin squamous cell carcinoma incidence http://purl.obolibrary.org/obo/MP_0010300 increased skin tumor incidence greater than the expected number of a skin carcinoma derived from stratified squamous epithelium, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0009705 abnormal midgut morphology http://purl.obolibrary.org/obo/MP_0003119 abnormal digestive system development any structural anomaly of the portion of the embryonic gut between the foregut and the hindgut, which originally is open to the yolk sac http://purl.obolibrary.org/obo/MP_0009706 absent midgut http://purl.obolibrary.org/obo/MP_0009705 abnormal midgut morphology absence of the portion of the embryonic gut between the foregut and the hindgut http://purl.obolibrary.org/obo/MP_0009707 absent external auditory canal http://purl.obolibrary.org/obo/MP_0006033 abnormal external auditory canal morphology absence of the canal that connects the outer and middle ear http://purl.obolibrary.org/obo/MP_0009708 vaginal septum http://purl.obolibrary.org/obo/MP_0001144 vagina atresia a longitudinal or transverse congenital partition within the muscular canal extending from outside of the body to the cervix; usually caused by incomplete fusion of the Mullerian ducts in embryogenesis http://purl.obolibrary.org/obo/MP_0009709 hydrometra http://purl.obolibrary.org/obo/MP_0001120 abnormal uterus morphology an accumulation in the uterine lumen of normal secretions that ordinarily drain from the body but are retained when the cervix or vagina is significantly or completely closed http://purl.obolibrary.org/obo/MP_0009710 anhedonia http://purl.obolibrary.org/obo/MP_0003360 abnormal depression-related behavior inability to experience pleasure in response to normally pleasurable stimuli http://purl.obolibrary.org/obo/MP_0009711 abnormal conditioned place preference behavior http://purl.obolibrary.org/obo/MP_0002062 abnormal associative learning anomaly in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment http://purl.obolibrary.org/obo/MP_0009712 impaired conditioned place preference behavior http://purl.obolibrary.org/obo/MP_0012317 impaired conditioning behavior decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment http://purl.obolibrary.org/obo/MP_0009713 enhanced conditioned place preference behavior http://purl.obolibrary.org/obo/MP_0012316 enhanced conditioning behavior increase in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment http://purl.obolibrary.org/obo/MP_0009714 thin epidermis stratum basale http://purl.obolibrary.org/obo/MP_0001231 abnormal epidermis stratum basale morphology reduced thickness of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells http://purl.obolibrary.org/obo/MP_0009715 thick epidermis stratum basale http://purl.obolibrary.org/obo/MP_0001231 abnormal epidermis stratum basale morphology increased thickness of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells http://purl.obolibrary.org/obo/MP_0009716 abnormal subcommissural organ morphology http://purl.obolibrary.org/obo/MP_0000631 abnormal neuroendocrine gland morphology any structural anomaly of the circumventricular organ derived from ependymal cells that is located at the junction of the third ventricle and the cerebral aqueduct and which secretes somatostatin http://purl.obolibrary.org/obo/MP_0009717 absent subcommissural organ http://purl.obolibrary.org/obo/MP_0009716 abnormal subcommissural organ morphology absence of the circumventricular organ derived from ependymal cells that is located at the junction of the third ventricle and the cerebral aqueduct and which secretes somatostatin http://purl.obolibrary.org/obo/MP_0009718 absent Purkinje cell layer http://purl.obolibrary.org/obo/MP_0000875 abnormal cerebellar Purkinje cell layer there is no evidence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex, normally containing the neuronal cell bodies of the Purkinje cells arranged side by side in a single layer, and candelabrum interneurons vertically oriented between the Purkinje cells http://purl.obolibrary.org/obo/MP_0009719 reduced cerebellar foliation http://purl.obolibrary.org/obo/MP_0000857 abnormal cerebellar foliation the cerebellar lobules are reduced in size or number http://purl.obolibrary.org/obo/MP_0009720 abnormal mammary gland pattern http://purl.obolibrary.org/obo/MP_0000628 abnormal mammary gland development aberration in the number of mammary glands that differentiate during early embryogenesis as it relates to the norm for the species http://purl.obolibrary.org/obo/MP_0009721 supernumerary mammary glands http://purl.obolibrary.org/obo/MP_0009720 abnormal mammary gland pattern more than the expected number of mammary glands differentiate during early embryogenesis http://purl.obolibrary.org/obo/MP_0009722 abnormal nipple development http://purl.obolibrary.org/obo/MP_0000628 abnormal mammary gland development an anomaly in the differentiation of the apex of the mammary gland on the integument surface into which the lactiferous ducts open http://purl.obolibrary.org/obo/MP_0009723 supernumerary nipples http://purl.obolibrary.org/obo/MP_0009722 abnormal nipple development differentiation of more than the normal number of structures located on the apex of the mammary gland on the integument surface into which the lactiferous ducts open http://purl.obolibrary.org/obo/MP_0009724 ectopic nipples http://purl.obolibrary.org/obo/MP_0009722 abnormal nipple development abnormal location of structures normally located on the apex of the mammary gland on the integument surface into which the lactiferous ducts open http://purl.obolibrary.org/obo/MP_0009725 absent lens vesicle http://purl.obolibrary.org/obo/MP_0001292 abnormal lens vesicle development absence of the ectodermal invagination that forms opposite the optic cup in the primordium of the lens of the eye http://purl.obolibrary.org/obo/MP_0009726 abnormal primordial meninx morphology http://purl.obolibrary.org/obo/MP_0000913 abnormal brain development any structural anomaly of the outermost mesenchymal covering of the developing brain and spinal cord that is composed of tough fibrous connective tissue from which the arachnoid mater, pia mater and dura mater are formed http://purl.obolibrary.org/obo/MP_0009727 abnormal navicular morphology http://purl.obolibrary.org/obo/MP_0005104 abnormal tarsal bone morphology any structural anomaly of the oval-shaped tarsal bone found between the talus and the 3 cuneiform bones http://purl.obolibrary.org/obo/MP_0009728 abnormal calcaneum morphology http://purl.obolibrary.org/obo/MP_0005104 abnormal tarsal bone morphology any structural anomaly of the largest quadrangular bone at the back of the tarsus; it forms the heel or hock and articulates with the talus above it http://purl.obolibrary.org/obo/MP_0009729 absent tarsus bones http://purl.obolibrary.org/obo/MP_0005104 abnormal tarsal bone morphology absence of the eight bones of the instep of the paw/foot: tibiale, talus, calcaneus, navicular, 3 cuneiform, and cuboid bones http://purl.obolibrary.org/obo/MP_0009732 ventricular premature beat http://purl.obolibrary.org/obo/MP_0001636 irregular heartbeat a heartbeat is initiated by abnormal electrical activation originating in the heart ventricles rather than by the sinoatrial node, the normal heartbeat initiator, before a normal heartbeat would occur http://purl.obolibrary.org/obo/MP_0009733 absent nipple http://purl.obolibrary.org/obo/MP_0009722 abnormal nipple development absence of the erectile projection at the apex of the mammary gland where the lactiferous ducts open http://purl.obolibrary.org/obo/MP_0009735 abnormal prostate gland development http://purl.obolibrary.org/obo/MP_0001158 abnormal prostate gland morphology anomaly in the formation or pattering of the of the prostate gland http://purl.obolibrary.org/obo/MP_0009737 prostate gland cysts http://purl.obolibrary.org/obo/MP_0001158 abnormal prostate gland morphology benign epithelial growths, often fluid-filled, within the gland in males that secretes part of the seminiferous fluid http://purl.obolibrary.org/obo/MP_0009738 enlarged prostate gland anterior lobe http://purl.obolibrary.org/obo/MP_0001163 abnormal prostate gland anterior lobe morphology increased size of the rodent prostate lobe that appears as a thin tubular structure, attached to the lesser curvature of the paired seminal vesicles http://purl.obolibrary.org/obo/MP_0009739 enlarged prostate gland dorsolateral lobe http://purl.obolibrary.org/obo/MP_0009381 abnormal prostate gland dorsolateral lobe morphology increased size of the rodent prostate lobe that lies in the triangular area between urethra and seminal vesicle http://purl.obolibrary.org/obo/MP_0009740 small prostate gland dorsolateral lobe http://purl.obolibrary.org/obo/MP_0009381 abnormal prostate gland dorsolateral lobe morphology reduced size of the rodent prostate lobe that lies in the triangular area between urethra and seminal vesicle http://purl.obolibrary.org/obo/MP_0009741 ectopic mammary gland http://purl.obolibrary.org/obo/MP_0009720 abnormal mammary gland pattern one or more of the expected number of mammary glands that differentiate during early embryogenesis is/ are not located according to the normal arrangement http://purl.obolibrary.org/obo/MP_0009742 increased corneal stroma thickness http://purl.obolibrary.org/obo/MP_0005300 abnormal corneal stroma morphology increased width of the lamellated connective tissue layer of the cornea http://purl.obolibrary.org/obo/MP_0009743 preaxial polydactyly http://purl.obolibrary.org/obo/MP_0000562 polydactyly duplication of all or part of the first ray on one or more of the autopods http://purl.obolibrary.org/obo/MP_0009744 postaxial polydactyly http://purl.obolibrary.org/obo/MP_0000562 polydactyly duplication of all or part of any of the rays except the first ray on one or more of the autopods http://purl.obolibrary.org/obo/MP_0009746 enhanced behavioral response to xenobiotic http://purl.obolibrary.org/obo/MP_0009745 abnormal behavioral response to xenobiotic increased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or reduced dosage threshold for the appearance of the behavioral response http://purl.obolibrary.org/obo/MP_0009747 impaired behavioral response to xenobiotic http://purl.obolibrary.org/obo/MP_0009745 abnormal behavioral response to xenobiotic decreased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response http://purl.obolibrary.org/obo/MP_0009748 abnormal behavioral response to addictive substance http://purl.obolibrary.org/obo/MP_0009745 abnormal behavioral response to xenobiotic any anomaly in the behavioral response induced by an addictive substance, such as induced hyperactivity or stereotypic behavior http://purl.obolibrary.org/obo/MP_0009749 enhanced behavioral response to addictive substance http://purl.obolibrary.org/obo/MP_0009748 abnormal behavioral response to addictive substance increased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response http://purl.obolibrary.org/obo/MP_0009750 impaired behavioral response to addictive substance http://purl.obolibrary.org/obo/MP_0009748 abnormal behavioral response to addictive substance decreased sensitivity to an addictive substance capable of inducing the appearance of behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response http://purl.obolibrary.org/obo/MP_0009752 enhanced behavioral response to nicotine http://purl.obolibrary.org/obo/MP_0020160 abnormal behavioral response to nicotine increased sensitivity to nicotine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response http://purl.obolibrary.org/obo/MP_0009753 enhanced behavioral response to morphine http://purl.obolibrary.org/obo/MP_0020159 abnormal behavioral response to morphine increased sensitivity to morphine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response http://purl.obolibrary.org/obo/MP_0009754 enhanced behavioral response to cocaine http://purl.obolibrary.org/obo/MP_0020158 abnormal behavioral response to cocaine increased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response http://purl.obolibrary.org/obo/MP_0009755 impaired behavioral response to alcohol http://purl.obolibrary.org/obo/MP_0020157 abnormal behavioral response to alcohol decreased sensitivity to alcohol resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response http://purl.obolibrary.org/obo/MP_0009756 impaired behavioral response to nicotine http://purl.obolibrary.org/obo/MP_0020160 abnormal behavioral response to nicotine decreased sensitivity to nicotine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response http://purl.obolibrary.org/obo/MP_0009757 impaired behavioral response to morphine http://purl.obolibrary.org/obo/MP_0020159 abnormal behavioral response to morphine decreased sensitivity to morphine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response http://purl.obolibrary.org/obo/MP_0009758 impaired behavioral response to cocaine http://purl.obolibrary.org/obo/MP_0020158 abnormal behavioral response to cocaine decreased sensitivity to cocaine resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response http://purl.obolibrary.org/obo/MP_0009759 abnormal hair follicle bulge morphology http://purl.obolibrary.org/obo/MP_0010684 abnormal hair follicle outer root sheath morphology any structural anomaly in the area located in the bottom of the permanent portion of a resting (telogen) hair follicle where the cells of the external root sheath of the hair follicle are contiguous with the basal layer of the epidermis; this portion of the follicle is involved in the generation of a new hair at the onset of the hair growth cycle (anagen) and contains the hair follicle stem cells http://purl.obolibrary.org/obo/MP_0009760 abnormal mitotic spindle morphology http://purl.obolibrary.org/obo/MP_0004046 abnormal mitosis any structural anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis http://purl.obolibrary.org/obo/MP_0009761 abnormal meiotic spindle morphology http://purl.obolibrary.org/obo/MP_0001930 abnormal meiosis an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during meiosis http://purl.obolibrary.org/obo/MP_0009762 abnormal mitotic spindle assembly checkpoint http://purl.obolibrary.org/obo/MP_0004046 abnormal mitosis an anomaly in the process that normally prevents inaccurate segregation of chromosome by inhibiting cell-cycle progression in response to a signal generated by mitotic spindle damage or by chromosomes that have not attached to microtubules http://purl.obolibrary.org/obo/MP_0009763 increased sensitivity to induced morbidity/mortality http://purl.obolibrary.org/obo/MP_0020148 abnormal sensitivity to induced morbidity/mortality decrease in the amount of an external agent required to cause death or diseased state http://purl.obolibrary.org/obo/MP_0009765 abnormal xenobiotic induced morbidity/mortality http://purl.obolibrary.org/obo/MP_0008872 abnormal physiological response to xenobiotic any anomaly in induction of a diseased state or death caused by a foreign compound http://purl.obolibrary.org/obo/MP_0009766 increased sensitivity to xenobiotic induced morbidity/mortality http://purl.obolibrary.org/obo/MP_0009765 abnormal xenobiotic induced morbidity/mortality decrease in the amount of a foreign compound required to cause death or diseased state http://purl.obolibrary.org/obo/MP_0009767 decreased sensitivity to xenobiotic induced morbidity/mortality http://purl.obolibrary.org/obo/MP_0009765 abnormal xenobiotic induced morbidity/mortality increase in the amount of a foreign compound required to cause death or diseased state http://purl.obolibrary.org/obo/MP_0009769 abnormal meiotic spindle assembly checkpoint http://purl.obolibrary.org/obo/MP_0001930 abnormal meiosis an anomaly in the process that normally prevents inaccurate segregation of chromosomes by inhibiting cell-cycle progression in response to a signal generated by meiotic spindle damage or by chromosomes that have not attached to microtubules http://purl.obolibrary.org/obo/MP_0009770 abnormal optic chiasm morphology http://purl.obolibrary.org/obo/MP_0001330 abnormal optic nerve morphology any structural anomaly in the flattened quadrangular body that is the point of crossing of the fibers of the optic nerves http://purl.obolibrary.org/obo/MP_0009771 absent optic chiasm http://purl.obolibrary.org/obo/MP_0009770 abnormal optic chiasm morphology absence of the flattened quadrangular body that is the point of crossing of the fibers of the optic nerves http://purl.obolibrary.org/obo/MP_0009772 abnormal retinal development http://purl.obolibrary.org/obo/MP_0001325 abnormal retina morphology anomaly in any of the steps during embryogenesis that produce the nerve layer lining in the back of the eye which senses light, and creates impulses that travel through the optic nerve to the brain http://purl.obolibrary.org/obo/MP_0009773 absent retina http://purl.obolibrary.org/obo/MP_0001325 abnormal retina morphology absence of the nerve layer lining the back of the eye that senses light, and creates impulses that travel through the optic nerve to the brain http://purl.obolibrary.org/obo/MP_0009774 abnormal behavioral withdrawal response http://purl.obolibrary.org/obo/MP_0009748 abnormal behavioral response to addictive substance anomaly in the intensity, duration, or type of behaviors displayed after discontinuation of an addictive substance http://purl.obolibrary.org/obo/MP_0009775 increased behavioral withdrawal response http://purl.obolibrary.org/obo/MP_0009774 abnormal behavioral withdrawal response increase in the intensity or duration of behaviors displayed after discontinuation of an addictive substance http://purl.obolibrary.org/obo/MP_0009776 decreased behavioral withdrawal response http://purl.obolibrary.org/obo/MP_0009774 abnormal behavioral withdrawal response decrease in the intensity or duration of behaviors displayed after discontinuation of an addictive substance http://purl.obolibrary.org/obo/MP_0009777 abnormal behavioral response to anesthetic http://purl.obolibrary.org/obo/MP_0009745 abnormal behavioral response to xenobiotic anomaly in the behavioral changes that follow exposure to an anesthetizing agent http://purl.obolibrary.org/obo/MP_0009778 impaired behavioral response to anesthetic http://purl.obolibrary.org/obo/MP_0009777 abnormal behavioral response to anesthetic decrease or delay in the behavioral changes that follow exposure to a given amount of an anesthetizing agent http://purl.obolibrary.org/obo/MP_0009779 enhanced behavioral response to anesthetic http://purl.obolibrary.org/obo/MP_0009777 abnormal behavioral response to anesthetic increase or exceleration in the behavioral changes that follow exposure to a given amount of an anesthetizing agent http://purl.obolibrary.org/obo/MP_0009780 abnormal chondrocyte physiology http://purl.obolibrary.org/obo/MP_0001533 abnormal skeleton physiology any functional anomaly of nondividing cartilage cells http://purl.obolibrary.org/obo/MP_0009782 abnormal basicranium angle http://purl.obolibrary.org/obo/MP_0010029 abnormal basicranium morphology a deviation from the expected angle formed by a line representing the floor of the anterior cranial fossa intersecting a line representing the axis of the clivus of the base of the skull http://purl.obolibrary.org/obo/MP_0009783 abnormal melanoblast morphology http://purl.obolibrary.org/obo/MP_0009845 abnormal neural crest cell morphology any structural anomaly of a cell that originates from the neural crest and differentiates into a pigment cell http://purl.obolibrary.org/obo/MP_0009784 abnormal melanoblast migration http://purl.obolibrary.org/obo/MP_0009783 abnormal melanoblast morphology any anomaly in the movement of the cells that originate from the neural crest and differentiate into pigment cells http://purl.obolibrary.org/obo/MP_0009785 altered susceptibility to infection induced morbidity/mortality http://purl.obolibrary.org/obo/MP_0001793 altered susceptibility to infection differences from the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens http://purl.obolibrary.org/obo/MP_0009786 decreased susceptibility to infection induced morbidity/mortality http://purl.obolibrary.org/obo/MP_0009785 altered susceptibility to infection induced morbidity/mortality reduced likelihood that an organism will display the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens http://purl.obolibrary.org/obo/MP_0009787 increased susceptibility to infection induced morbidity/mortality http://purl.obolibrary.org/obo/MP_0009785 altered susceptibility to infection induced morbidity/mortality increased likelihood that an organism will display the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens http://purl.obolibrary.org/obo/MP_0009788 increased susceptibility to bacterial infection induced morbidity/mortality http://purl.obolibrary.org/obo/MP_0009787 increased susceptibility to infection induced morbidity/mortality increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria http://purl.obolibrary.org/obo/MP_0009789 decreased susceptibility to bacterial infection induced morbidity/mortality http://purl.obolibrary.org/obo/MP_0009786 decreased susceptibility to infection induced morbidity/mortality reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria http://purl.obolibrary.org/obo/MP_0009790 decreased susceptibility to viral infection induced morbidity/mortality http://purl.obolibrary.org/obo/MP_0009786 decreased susceptibility to infection induced morbidity/mortality reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus http://purl.obolibrary.org/obo/MP_0009791 increased susceptibility to viral infection induced morbidity/mortality http://purl.obolibrary.org/obo/MP_0009787 increased susceptibility to infection induced morbidity/mortality increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus http://purl.obolibrary.org/obo/MP_0009792 seborrheic dermatitis http://purl.obolibrary.org/obo/MP_0001194 dermatitis an inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp or inside the ear, with or without reddened skin http://purl.obolibrary.org/obo/MP_0009793 sebaceous gland hypertrophy http://purl.obolibrary.org/obo/MP_0000652 enlarged sebaceous gland increase in the bulk size of the sebum secreting glands of the hair shaft due to cell enlargement http://purl.obolibrary.org/obo/MP_0009794 sebaceous gland hyperplasia http://purl.obolibrary.org/obo/MP_0000652 enlarged sebaceous gland overdevelopment and increased size of the sebum secreting glands of the hair shaft, usually due to an increase in the number of cells http://purl.obolibrary.org/obo/MP_0009795 epidermal spongiosis http://purl.obolibrary.org/obo/MP_0001786 skin edema intercellular edema within the epidermis http://purl.obolibrary.org/obo/MP_0009796 abnormal base-excision repair http://purl.obolibrary.org/obo/MP_0008058 abnormal DNA repair any anomaly in the process whereby an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate; the small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase http://purl.obolibrary.org/obo/MP_0009797 abnormal mismatch repair http://purl.obolibrary.org/obo/MP_0008058 abnormal DNA repair any functional anomaly in the system that promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination http://purl.obolibrary.org/obo/MP_0009798 abnormal ophthalmic nerve morphology http://purl.obolibrary.org/obo/MP_0001065 abnormal trigeminal nerve morphology any structural anomaly of the sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the orbit and its contents, the nasal cavity and the skin of the nose and forehead http://purl.obolibrary.org/obo/MP_0009799 abnormal maxillary nerve morphology http://purl.obolibrary.org/obo/MP_0001065 abnormal trigeminal nerve morphology any structural anomaly of the sensory nerve subdivision of the trigeminal nerve that transmits sensory information from the palate, upper teeth and gingiva, the skin between the palpebral fissure and the mouth, and from the nasal cavity and maxillary sinuses http://purl.obolibrary.org/obo/MP_0009801 abnormal hair cortex keratinization http://purl.obolibrary.org/obo/MP_0003811 abnormal hair cortex morphology any defect in the formation of the fibrous elements found in the hair cortex comprising acidic (Type I ) and basic (Type II) proteins that give hair such aspects as resilience, and elasticity http://purl.obolibrary.org/obo/MP_0009802 abnormal median aperture morphology http://purl.obolibrary.org/obo/MP_0002200 abnormal brain ventricular system morphology any structural anomaly in the large midline opening of the posterior inferior part of the roof of the fourth ventricle that connects the fourth ventricle to the posterior cerebromedullary cistern and the spinal cord http://purl.obolibrary.org/obo/MP_0009803 abnormal lateral aperture morphology http://purl.obolibrary.org/obo/MP_0002200 abnormal brain ventricular system morphology any structural anomaly of the two lateral openings of the fourth ventricle into the subarachnoid space at the cerebellopontine angle http://purl.obolibrary.org/obo/MP_0009804 abnormal interventricular foramen morphology http://purl.obolibrary.org/obo/MP_0002200 abnormal brain ventricular system morphology any structural anomaly of the paired channels that connect the lateral and third ventricles and allows cerebrospinal fluid produced in the lateral ventricles to flow into the third ventricle http://purl.obolibrary.org/obo/MP_0009805 absent median aperture http://purl.obolibrary.org/obo/MP_0009802 abnormal median aperture morphology absence of the large midline opening of the posterior inferior part of the roof of the fourth ventricle that connects the fourth ventricle to the posterior cerebromedullary cistern and the spinal cord http://purl.obolibrary.org/obo/MP_0009807 abnormal pelvic ligament morphology http://purl.obolibrary.org/obo/MP_0005504 abnormal ligament morphology any structural anomaly of the dorsal sacroiliac, the sacrotuberal and/or the iliolumbar ligaments associated with the bony ring formed by the pair of hip bones fused at the symphysis and their firm articulation with the sacrum http://purl.obolibrary.org/obo/MP_0009809 abnormal urine uric acid level http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis anomaly in the amount in the urine of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine http://purl.obolibrary.org/obo/MP_0009810 increased urine uric acid level http://purl.obolibrary.org/obo/MP_0009809 abnormal urine uric acid level greater amount in the urine of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine http://purl.obolibrary.org/obo/MP_0009811 abnormal prostaglandin level http://purl.obolibrary.org/obo/MP_0001547 abnormal lipid level anomaly in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation http://purl.obolibrary.org/obo/MP_0009812 abnormal bradykinin level http://purl.obolibrary.org/obo/MP_0008835 abnormal intercellular signaling peptide or protein level abnormal concentration of a potent, short-lived vasoactive peptide that causes arteriolar dilation and increased capillary permeability http://purl.obolibrary.org/obo/MP_0009813 abnormal leukotriene level http://purl.obolibrary.org/obo/MP_0001547 abnormal lipid level abnormal concentration of a family of mediators derived from arachidonic acid which normally stimulate smooth muscle contraction, increase vascular permeability, and may be chemoattractants for inflammatory cells http://purl.obolibrary.org/obo/MP_0009814 increased prostaglandin level http://purl.obolibrary.org/obo/MP_0009811 abnormal prostaglandin level increase in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation http://purl.obolibrary.org/obo/MP_0009815 decreased prostaglandin level http://purl.obolibrary.org/obo/MP_0009811 abnormal prostaglandin level reduction in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation http://purl.obolibrary.org/obo/MP_0009816 increased leukotriene level http://purl.obolibrary.org/obo/MP_0009813 abnormal leukotriene level increased concentration of a family of mediators derived from arachidonic acid which normally stimulate smooth muscle contraction, increase vascular permeability, and may be chemoattractants for inflammatory cells http://purl.obolibrary.org/obo/MP_0009817 decreased leukotriene level http://purl.obolibrary.org/obo/MP_0009813 abnormal leukotriene level reduced concentration of a family of mediators derived from arachidonic acid which normally stimulate smooth muscle contraction, increase vascular permeability, and may be chemoattractants for inflammatory cells http://purl.obolibrary.org/obo/MP_0009818 abnormal thromboxane level http://purl.obolibrary.org/obo/MP_0001547 abnormal lipid level anomalous concentration in the body of any of several compounds, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels http://purl.obolibrary.org/obo/MP_0009820 abnormal liver vasculature morphology http://purl.obolibrary.org/obo/MP_0001614 abnormal blood vessel morphology any structural anomaly of the blood vessel network of the bile-secreting exocrine gland http://purl.obolibrary.org/obo/MP_0009821 abnormal vestibular aqueduct morphology http://purl.obolibrary.org/obo/MP_0000026 abnormal inner ear morphology any structural anomaly in the small bony canal that surrounds the endolymphatic duct canal and links the vestibule of the inner ear to the posterior part of the internal surface of the petrous temporal bone http://purl.obolibrary.org/obo/MP_0009822 abnormal subarcuate fossa morphology http://purl.obolibrary.org/obo/MP_0005272 abnormal temporal bone morphology any structural anomaly of the irregular depression found on the posterior inner surface of the petrous portion of the temporal bone just below its crest and above and lateral to the internal acoustic meatus http://purl.obolibrary.org/obo/MP_0009823 abnormal sphingomyelin level http://purl.obolibrary.org/obo/MP_0004777 abnormal phospholipid level deviation in the expected amount of any of a group of phospholipids that are found especially in, but not restricted to, nerve tissue and yield sphingosine, choline, a fatty acid, and phosphoric acid upon hydrolysis http://purl.obolibrary.org/obo/MP_0009824 spermatic granuloma http://purl.obolibrary.org/obo/MP_0002631 abnormal epididymis morphology a granulomatous nodular lesion that appears in the region of epididymis and can be large enough to totally occlude the epididymal lumen; sperm granulomas are rounded or irregular in shape, and contain dense aggregates of immune cells and degenerating sperm resulting from an autoimmune response against sperm-associated antigens exposed following biochemical or surgical insult (e.g. vasectomy) to the epididymal epithelium http://purl.obolibrary.org/obo/MP_0009825 cornea ulcer http://purl.obolibrary.org/obo/MP_0001312 abnormal cornea morphology an area of tissue erosion in the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure http://purl.obolibrary.org/obo/MP_0009826 abnormal dermis reticular layer collagen network http://purl.obolibrary.org/obo/MP_0005081 abnormal dermis reticular layer morphology an anomaly in the amount or arrangement of the criss-crossing collagen fibers that form a strong elastic network normally arranged in parallel to the surface of the skin http://purl.obolibrary.org/obo/MP_0009827 skin detachment http://purl.obolibrary.org/obo/MP_0009931 abnormal skin appearance loss of sections of skin either spontaneously or after gentle handling http://purl.obolibrary.org/obo/MP_0009828 increased tumor latency http://purl.obolibrary.org/obo/MP_0010307 abnormal tumor latency later onset of tumor occurrence than expected http://purl.obolibrary.org/obo/MP_0009829 enlarged eye anterior chamber http://purl.obolibrary.org/obo/MP_0005205 abnormal eye anterior chamber morphology increased size of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens http://purl.obolibrary.org/obo/MP_0009830 abnormal sperm connecting piece morphology http://purl.obolibrary.org/obo/MP_0008892 abnormal sperm flagellum morphology any structural anomaly in the segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum http://purl.obolibrary.org/obo/MP_0009831 abnormal sperm midpiece morphology http://purl.obolibrary.org/obo/MP_0008892 abnormal sperm flagellum morphology any structural anomaly of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece http://purl.obolibrary.org/obo/MP_0009832 abnormal sperm mitochondrial sheath morphology http://purl.obolibrary.org/obo/MP_0009831 abnormal sperm midpiece morphology any structural anomaly or impairment of the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum http://purl.obolibrary.org/obo/MP_0009833 absent sperm mitochondrial sheath http://purl.obolibrary.org/obo/MP_0009832 abnormal sperm mitochondrial sheath morphology absence of the tightly packed helical sheath of ATP-producing mitochondria, normally found in the midpiece of the sperm flagellum http://purl.obolibrary.org/obo/MP_0009834 abnormal sperm annulus morphology http://purl.obolibrary.org/obo/MP_0009831 abnormal sperm midpiece morphology any structural anomaly of the ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity http://purl.obolibrary.org/obo/MP_0009835 absent sperm annulus http://purl.obolibrary.org/obo/MP_0009834 abnormal sperm annulus morphology absence of the ring-like, filamentous structure located at the midpiece-principal piece junction of the sperm flagellum, usually associated with a bent tail morphology http://purl.obolibrary.org/obo/MP_0009836 abnormal sperm principal piece morphology http://purl.obolibrary.org/obo/MP_0008892 abnormal sperm flagellum morphology any structural anomaly in the segment of the sperm flagellum where the mitochondrial sheath ends and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs; the principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece http://purl.obolibrary.org/obo/MP_0009837 abnormal sperm end piece morphology http://purl.obolibrary.org/obo/MP_0008892 abnormal sperm flagellum morphology any structural anomaly in the short remaining region of the sperm flagellum, which contains only the axoneme surrounded by the plasma membrane http://purl.obolibrary.org/obo/MP_0009838 abnormal sperm axoneme morphology http://purl.obolibrary.org/obo/MP_0008892 abnormal sperm flagellum morphology any structural anomaly of the central core of the sperm flagellum, composed of a ring of 9 outer microtubule doublets surrounding a central pair; inner and outer dynein arms project from each of the outer 9 doublets, and these arms are responsible for generating the motive force of the flagellum; in addition, 9 radial spokes, each of which originates from 1 of the 9 outer microtubular doublet pairs, project inward toward the central pair in a helical fashion http://purl.obolibrary.org/obo/MP_0009839 multiflagellated sperm http://purl.obolibrary.org/obo/MP_0008892 abnormal sperm flagellum morphology presence of more than one sperm flagellum, displaying either one common origin from the sperm head or multiple origins from the same sperm head http://purl.obolibrary.org/obo/MP_0009840 abnormal foam cell morphology http://purl.obolibrary.org/obo/MP_0000358 abnormal cell morphology any structural anomaly of a cell with a vacuolated appearance due to abnormal deposition and retention of lipoproteins, and typically seen in atherolosclerotic lesions, as well as other conditions, and derived from or related to the group of cells having the ability to take up and sequester inert particles and vital dyes, including macrophages and macrophage precursors, specialized endothelial cells lining the sinusoids of the liver, spleen, and bone marrow, and macrophages of lymphatic tissue and fibroblasts of bone marrow http://purl.obolibrary.org/obo/MP_0009841 foam cell reticulosis http://purl.obolibrary.org/obo/MP_0009840 abnormal foam cell morphology an increase in cells with a vacuolated appearance due to abnormal deposition and retention of lipoproteins and derived from or related to the group of cells having the ability to take up and sequester inert particles and vital dyes, including macrophages and macrophage precursors, specialized endothelial cells lining the sinusoids of the liver, spleen, and bone marrow, and macrophages of lymphatic tissue and fibroblasts of bone marrow http://purl.obolibrary.org/obo/MP_0009842 abnormal neural crest cell proliferation http://purl.obolibrary.org/obo/MP_0012745 abnormal neural crest cell physiology any anomaly in the ability of the of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult, to undergo rapid expansion by cell division http://purl.obolibrary.org/obo/MP_0009843 decreased neural crest cell number http://purl.obolibrary.org/obo/MP_0009845 abnormal neural crest cell morphology reduction in the number of ransient and migratory group of cells that emerge from the dorsal region of the neural tube and disperse to many peripheral locations to form various tissues of the adult http://purl.obolibrary.org/obo/MP_0009844 abnormal neural crest cell apoptosis http://purl.obolibrary.org/obo/MP_0012745 abnormal neural crest cell physiology change in the timing or the number of neural crest cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0009845 abnormal neural crest cell morphology http://purl.obolibrary.org/obo/MP_0009846 abnormal neural crest morphology any structural anomaly of the transient and highly migratory group of cells that delaminate in early embryonic development from the dorsal neural tube and give rise to a variety of differentiated cell types, including (1) the neurons and glial cells of the sensory, sympathetic, and parasympathetic nervous systems, (2) the epinephrine-producing (medulla) cells of the adrenal gland, (3) the pigment-containing cells of the epidermis, and (4) many of the skeletal and connective tissue components of the head http://purl.obolibrary.org/obo/MP_0009846 abnormal neural crest morphology http://purl.obolibrary.org/obo/MP_0002151 abnormal neural tube morphology/development any structural anomaly of the specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types http://purl.obolibrary.org/obo/MP_0009847 abnormal scrotum pigmentation http://purl.obolibrary.org/obo/MP_0002669 abnormal scrotum morphology anomaly in the coloration of the scrotum due to changes in the amount, shape, or distribution of cells producing pigment http://purl.obolibrary.org/obo/MP_0009848 increased horizontal stereotypic behavior http://purl.obolibrary.org/obo/MP_0001409 increased stereotypic behavior increase in the frequency of repetitive rearings (greater than one per second) http://purl.obolibrary.org/obo/MP_0009849 increased vertical stereotypic behavior http://purl.obolibrary.org/obo/MP_0001409 increased stereotypic behavior increase in the frequency of vertical crossings (greater than one per second) http://purl.obolibrary.org/obo/MP_0009850 embryonic lethality between implantation and placentation http://purl.obolibrary.org/obo/MP_0013292 embryonic lethality prior to organogenesis death anytime between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9) http://purl.obolibrary.org/obo/MP_0009851 abnormal Sertoli cell phagocytosis http://purl.obolibrary.org/obo/MP_0001932 abnormal spermiogenesis altered ability of the Sertoli cells to endocytose and degrade the apoptotic spermatogenic cells and residual bodies (shed cytoplasts) during the maturation phase of spermiogenesis; normally, greater than 50 per cent of differentiating spermatogenic cells undergo apoptosis before maturing into spermatozoa, and these cells are selectively and rapidly eliminated through phagocytosis by Sertoli cells http://purl.obolibrary.org/obo/MP_0009852 increased Sertoli cell phagocytosis http://purl.obolibrary.org/obo/MP_0009851 abnormal Sertoli cell phagocytosis enhanced phagocytic activity of testicular Sertoli cells http://purl.obolibrary.org/obo/MP_0009853 decreased Sertoli cell phagocytosis http://purl.obolibrary.org/obo/MP_0009851 abnormal Sertoli cell phagocytosis decreased phagocytic activity of testicular Sertoli cells http://purl.obolibrary.org/obo/MP_0009854 impaired gastric peristalsis http://purl.obolibrary.org/obo/MP_0011082 abnormal gastrointestinal motility an increase in the time required for solids or liquids to leave the stomach and enter the intestines http://purl.obolibrary.org/obo/MP_0009855 midface retrusion http://purl.obolibrary.org/obo/MP_0011495 abnormal head shape the portion of the face comprising the nasal, maxillary, and zygomatic bones is shortened relative to the calvaria and located posterior to the normal position http://purl.obolibrary.org/obo/MP_0009856 failure of ejaculation http://purl.obolibrary.org/obo/MP_0001378 abnormal ejaculation inability to propulse semen from the genital ducts and the urethra to the exterior within a defined test period http://purl.obolibrary.org/obo/MP_0009857 absent kidney cortex http://purl.obolibrary.org/obo/MP_0000521 abnormal kidney cortex morphology absence of the outer portion of the kidney located between the renal capsule and the renal medulla and involved in ultrafiltration http://purl.obolibrary.org/obo/MP_0009859 eye opacity http://purl.obolibrary.org/obo/MP_0002092 abnormal eye morphology changes in the eye grossly observed as a milky or cloudy appearance that may be progressive and persistent throughout life http://purl.obolibrary.org/obo/MP_0009860 nephrosclerosis http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology hardening of the kidney from overgrowth, infiltration by fibrous connective tissue, and contraction of the interstitial connective tissue; often a result of renovascular diseases or chronic hypertension http://purl.obolibrary.org/obo/MP_0009861 abnormal pyloric sphincter morphology http://purl.obolibrary.org/obo/MP_0010785 abnormal stomach pyloric region morphology any structural anomaly of the thick circular layer of gastric musculature encircling the gastroduodenal junction at the gastric outlet of the stomach http://purl.obolibrary.org/obo/MP_0009864 abnormal aorta endothelium morphology http://purl.obolibrary.org/obo/MP_0009872 abnormal aorta tunica intima morphology any structural anomaly of the thin layer of flat cells that line the aorta and form a barrier between circulating blood in the lumen and the rest of the vessel wall http://purl.obolibrary.org/obo/MP_0009865 abnormal aorta smooth muscle morphology http://purl.obolibrary.org/obo/MP_0009873 abnormal aorta tunica media morphology any structural anomaly of the nonstriated, involuntary muscle tissue located in the wall of the aorta http://purl.obolibrary.org/obo/MP_0009866 abnormal aorta wall morphology http://purl.obolibrary.org/obo/MP_0000272 abnormal aorta morphology any structural anomaly of the part of the aorta that encloses the luminal space http://purl.obolibrary.org/obo/MP_0009867 abnormal ascending aorta morphology http://purl.obolibrary.org/obo/MP_0010468 abnormal thoracic aorta morphology any structural anomaly of the portion of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch and from which the coronary arteries arise http://purl.obolibrary.org/obo/MP_0009868 abnormal descending thoracic aorta morphology http://purl.obolibrary.org/obo/MP_0009869 abnormal descending aorta morphology any structural anomaly of the part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest http://purl.obolibrary.org/obo/MP_0009869 abnormal descending aorta morphology http://purl.obolibrary.org/obo/MP_0000272 abnormal aorta morphology any structural anomaly of the part of the aorta extending from the arch of aorta to the point where it divides into the common iliac arteries http://purl.obolibrary.org/obo/MP_0009870 abnormal abdominal aorta morphology http://purl.obolibrary.org/obo/MP_0009869 abnormal descending aorta morphology any structural anomaly of the part of the descending aorta that begins at the diaphragm and continues to the point of the common iliac arteries, and supplies oxygenated blood to all of the abdominal and pelvic organs and the legs http://purl.obolibrary.org/obo/MP_0009871 abnormal aorta tunica adventitia morphology http://purl.obolibrary.org/obo/MP_0009866 abnormal aorta wall morphology any structural anomaly of the outermost layer of the aorta wall, containing connective tissue and collagen and elastic fibers http://purl.obolibrary.org/obo/MP_0009872 abnormal aorta tunica intima morphology http://purl.obolibrary.org/obo/MP_0009866 abnormal aorta wall morphology any structural anomaly of the innermost layer of the aorta, containing the endothelium and an inner elastic membrane http://purl.obolibrary.org/obo/MP_0009873 abnormal aorta tunica media morphology http://purl.obolibrary.org/obo/MP_0009866 abnormal aorta wall morphology any structural anomaly of the middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers http://purl.obolibrary.org/obo/MP_0009874 abnormal interdigital cell death http://purl.obolibrary.org/obo/MP_0006280 abnormal digit development change in the expected number of cells undergoing programmed cell death (apoptosis) in the autopod during development, precluding the sculpting of normal digits http://purl.obolibrary.org/obo/MP_0009875 absent interdigital cell death http://purl.obolibrary.org/obo/MP_0009874 abnormal interdigital cell death no cells undergo programmed cell death (apoptosis) in the autopod during development, precluding the sculpting of any digits http://purl.obolibrary.org/obo/MP_0009876 increased cellular sensitivity to thiophosphamide http://purl.obolibrary.org/obo/MP_0008402 increased cellular sensitivity to alkylating agents a greater frequency of chromosomal aberrations is found in cells after exposure to the alkylating agent thiophosphamide http://purl.obolibrary.org/obo/MP_0009877 exostosis http://purl.obolibrary.org/obo/MP_0003795 abnormal bone structure a projection of bone, sometimes a benign tumor (osteochondroma), that is capped by cartilage and arises from a bone that develops from cartilage; these usually arise on the joints of bones and are most commonly found on ribs, and also the ankles, knees, shoulders, elbows and hips http://purl.obolibrary.org/obo/MP_0009878 decreased susceptibility to bone fracture http://purl.obolibrary.org/obo/MP_0004149 increased bone strength reduced probability that injury or disease will result in damaged or broken bones http://purl.obolibrary.org/obo/MP_0009879 abnormal arcus anterior morphology http://purl.obolibrary.org/obo/MP_0004607 abnormal cervical atlas morphology any structural anomaly in the arch that connects the lateral masses of the atlas anteriorly and articulates with the anterior articular facet of the dens of the axis http://purl.obolibrary.org/obo/MP_0009880 microstomia http://purl.obolibrary.org/obo/MP_0000452 abnormal mouth morphology abnormally decreased size of the mouth http://purl.obolibrary.org/obo/MP_0009881 macrostomia http://purl.obolibrary.org/obo/MP_0000452 abnormal mouth morphology excessive width of the mouth http://purl.obolibrary.org/obo/MP_0009882 absent palatal shelf http://purl.obolibrary.org/obo/MP_0009890 cleft secondary palate absence of the palatal projections from the inner part of the maxillary processes that fuse to form the secondary palate http://purl.obolibrary.org/obo/MP_0009883 palatal shelf hypoplasia http://purl.obolibrary.org/obo/MP_0009890 cleft secondary palate reduced size of the palatal projections from the inner part of the maxillary processes that fuse to form the secondary palate, often due to reduced cell number http://purl.obolibrary.org/obo/MP_0009884 palatal shelf fusion with tongue or mandible http://purl.obolibrary.org/obo/MP_0009890 cleft secondary palate palatal shelves do not elevate during development and instead fuse with tongue tissues or with the mandible tissues http://purl.obolibrary.org/obo/MP_0009885 abnormal palatal shelf elevation http://purl.obolibrary.org/obo/MP_0009890 cleft secondary palate any anomaly in the process in which the palatal shelves move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue http://purl.obolibrary.org/obo/MP_0009886 failure of palatal shelf elevation http://purl.obolibrary.org/obo/MP_0009885 abnormal palatal shelf elevation the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue http://purl.obolibrary.org/obo/MP_0009887 abnormal palatal shelf fusion at midline http://purl.obolibrary.org/obo/MP_0009890 cleft secondary palate any anomaly in the process in which the palatal shelves grow toward the midline and adhere along the medial edge epithelia, forming the midline epithelial seam which disappears in later stages http://purl.obolibrary.org/obo/MP_0009888 palatal shelves fail to meet at midline http://purl.obolibrary.org/obo/MP_0009887 abnormal palatal shelf fusion at midline polarized growth towards the midline following palatal shelf elevation does not occur http://purl.obolibrary.org/obo/MP_0009889 persistence of medial edge epithelium during palatal shelf fusion http://purl.obolibrary.org/obo/MP_0009887 abnormal palatal shelf fusion at midline palatal shelves meet at the midline during development but do not adhere along the medial edge epithelia, and fail to form the midline epithelial seam http://purl.obolibrary.org/obo/MP_0009890 cleft secondary palate http://purl.obolibrary.org/obo/MP_0000111 cleft palate congenital fissure of the tissues normally uniting to form the secondary palate http://purl.obolibrary.org/obo/MP_0009891 abnormal palate bone morphology http://purl.obolibrary.org/obo/MP_0003756 abnormal hard palate morphology any structural anomaly of the maxillary or palatine shelves that comprise the bones of the hard palate http://purl.obolibrary.org/obo/MP_0009892 palate bone hypoplasia http://purl.obolibrary.org/obo/MP_0009891 abnormal palate bone morphology reduced size of the maxillary or palatine shelves that comprise the bones of the hard palate, usually due to reduced cell number http://purl.obolibrary.org/obo/MP_0009893 cleft primary palate http://purl.obolibrary.org/obo/MP_0000111 cleft palate congenital fissure of the tissues normally uniting to form the primary palate http://purl.obolibrary.org/obo/MP_0009894 absent hard palate http://purl.obolibrary.org/obo/MP_0003756 abnormal hard palate morphology absence of the anterior part of the palate that is supported by and includes the palatal extensions of the maxillary and palatine bones in the adult http://purl.obolibrary.org/obo/MP_0009895 decreased palatine bone horizontal plate size http://purl.obolibrary.org/obo/MP_0004537 abnormal palatine bone horizontal plate morphology reduced size of the bony plate of the palatine bone that normally fuses with maxillary shelf to form secondary (hard) palate http://purl.obolibrary.org/obo/MP_0009896 palatine bone horizontal plate hypoplasia http://purl.obolibrary.org/obo/MP_0009895 decreased palatine bone horizontal plate size underdevelopment, usually due to a deficiency in the number of cells, of the bony plate of the palatine bone that normally fuses with maxillary shelf to form secondary (hard) palate http://purl.obolibrary.org/obo/MP_0009897 decreased maxillary shelf size http://purl.obolibrary.org/obo/MP_0004538 abnormal maxillary shelf morphology reduced size of the bony projection of the maxilla that normally fuses with palatine shelf to form secondary (hard) palate http://purl.obolibrary.org/obo/MP_0009898 maxillary shelf hypoplasia http://purl.obolibrary.org/obo/MP_0009897 decreased maxillary shelf size underdevelopment, usually due to a deficiency in the number of cells, of the bony projection of the maxilla that normally fuses with palatine shelf to form secondary (hard) palate http://purl.obolibrary.org/obo/MP_0009899 hyoid bone hypoplasia http://purl.obolibrary.org/obo/MP_0009912 decreased hyoid bone size underdevelopment of the hyoid bone, usually due to a deficiency in the number of cells http://purl.obolibrary.org/obo/MP_0009900 vomer bone hypoplasia http://purl.obolibrary.org/obo/MP_0000098 abnormal vomer bone morphology underdevelopment of the vomer bone, usually due to a deficiency in the number of cells http://purl.obolibrary.org/obo/MP_0009901 abnormal frontonasal prominence morphology http://purl.obolibrary.org/obo/MP_0003935 abnormal craniofacial development any structural anomaly of an unpaired facial process in the embryo formed from the tissues surrounding the forebrain vesicle that develops into the forehead and bridge of the nose/snout http://purl.obolibrary.org/obo/MP_0009902 abnormal lateral nasal prominence morphology http://purl.obolibrary.org/obo/MP_0003935 abnormal craniofacial development any structural anomaly of the lateral area of the two branches of a horseshoe-shaped mesenchymal swelling in the future nasal region of the embryo; it separates the olfactory pit from the developing eye and the ala of the nose/snout develops from it http://purl.obolibrary.org/obo/MP_0009903 abnormal medial nasal prominence morphology http://purl.obolibrary.org/obo/MP_0003935 abnormal craniofacial development any structural anomaly of the central area of the two limbs of a horseshoe-shaped mesenchymal swelling that lie medial to the olfactory placode or pit in the future nasal region of the embryo; it joins with the ipsilateral maxillary prominence in the formation of half of the upper jaw, and the nasal tip and philtrum of the upper lip develop from it http://purl.obolibrary.org/obo/MP_0009904 tongue hypoplasia http://purl.obolibrary.org/obo/MP_0009907 decreased tongue size underdevelopment of the tongue, usually due to a deficiency in the number of cells http://purl.obolibrary.org/obo/MP_0009905 absent tongue http://purl.obolibrary.org/obo/MP_0000762 abnormal tongue morphology absence of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor http://purl.obolibrary.org/obo/MP_0009906 increased tongue size http://purl.obolibrary.org/obo/MP_0000762 abnormal tongue morphology greater size the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor http://purl.obolibrary.org/obo/MP_0009907 decreased tongue size http://purl.obolibrary.org/obo/MP_0000762 abnormal tongue morphology reduced size of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor http://purl.obolibrary.org/obo/MP_0009908 protruding tongue http://purl.obolibrary.org/obo/MP_0000762 abnormal tongue morphology the tongue extends out beyond the oral cavity past the lips; may be due to paralysis, oral cavity size, tongue hypoplasia or dysfunction of the hypoglossal nerve http://purl.obolibrary.org/obo/MP_0009909 bifid tongue http://purl.obolibrary.org/obo/MP_0000762 abnormal tongue morphology tongue is divided by a midline cleft http://purl.obolibrary.org/obo/MP_0009910 bifurcated tongue http://purl.obolibrary.org/obo/MP_0009909 bifid tongue tongue is split into two halves at the anterior tip; this is normal in some animals such as reptiles http://purl.obolibrary.org/obo/MP_0009911 increased hyoid bone size http://purl.obolibrary.org/obo/MP_0003056 abnormal hyoid bone morphology greater size of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles http://purl.obolibrary.org/obo/MP_0009912 decreased hyoid bone size http://purl.obolibrary.org/obo/MP_0003056 abnormal hyoid bone morphology reduced size of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles http://purl.obolibrary.org/obo/MP_0009913 abnormal hyoid bone greater horn morphology http://purl.obolibrary.org/obo/MP_0003056 abnormal hyoid bone morphology any structural anomaly of the larger and more lateral of the paired processes on either side of the hyoid bone http://purl.obolibrary.org/obo/MP_0009914 abnormal hyoid bone lesser horn morphology http://purl.obolibrary.org/obo/MP_0003056 abnormal hyoid bone morphology any structural anomaly of shorter and more medial of the paired processes on either side of the hyoid bone http://purl.obolibrary.org/obo/MP_0009915 absent hyoid bone lesser horns http://purl.obolibrary.org/obo/MP_0009914 abnormal hyoid bone lesser horn morphology absence of shorter and more medial of the paired processes on either side of the hyoid bone http://purl.obolibrary.org/obo/MP_0009916 absent hyoid bone greater horns http://purl.obolibrary.org/obo/MP_0009913 abnormal hyoid bone greater horn morphology absence of the larger and more lateral of the paired processes on either side of the hyoid bone http://purl.obolibrary.org/obo/MP_0009917 abnormal hyoid bone body morphology http://purl.obolibrary.org/obo/MP_0003056 abnormal hyoid bone morphology any structural anomaly of the main curve of the hyoid bone, from which the horns extend http://purl.obolibrary.org/obo/MP_0009918 abnormal stylohyoid ligament morphology http://purl.obolibrary.org/obo/MP_0005504 abnormal ligament morphology any structural anomaly of the fibrous cord that connects the tip of the styloid process of the temporal bone to the lesser horn of the hyoid bone http://purl.obolibrary.org/obo/MP_0009919 abnormal transitional stage T1 B cell morphology http://purl.obolibrary.org/obo/MP_0008188 abnormal transitional stage B cell morphology any structural anomaly of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative http://purl.obolibrary.org/obo/MP_0009920 abnormal transitional stage T2 B cell morphology http://purl.obolibrary.org/obo/MP_0008188 abnormal transitional stage B cell morphology any structural anomaly of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles http://purl.obolibrary.org/obo/MP_0009921 abnormal transitional stage T3 B cell morphology http://purl.obolibrary.org/obo/MP_0008188 abnormal transitional stage B cell morphology any structural anomaly of a type of a transitional stage B cell that expresses surface IgM and IgD, and CD62L; it is an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, and CD62L-positive http://purl.obolibrary.org/obo/MP_0009922 increased transitional stage T1 B cell number http://purl.obolibrary.org/obo/MP_0009919 abnormal transitional stage T1 B cell morphology greater number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative http://purl.obolibrary.org/obo/MP_0009923 decreased transitional stage T1 B cell number http://purl.obolibrary.org/obo/MP_0009919 abnormal transitional stage T1 B cell morphology reduced number of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative http://purl.obolibrary.org/obo/MP_0009924 absent transitional stage T1 B cells http://purl.obolibrary.org/obo/MP_0009923 decreased transitional stage T1 B cell number absence of a type of transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen; this cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative http://purl.obolibrary.org/obo/MP_0009925 increased transitional stage T2 B cell number http://purl.obolibrary.org/obo/MP_0009920 abnormal transitional stage T2 B cell morphology greater number of a type of a transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles http://purl.obolibrary.org/obo/MP_0009926 decreased transitional stage T2 B cell number http://purl.obolibrary.org/obo/MP_0009920 abnormal transitional stage T2 B cell morphology reduced number of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles http://purl.obolibrary.org/obo/MP_0009927 absent transitional stage T2 B cells http://purl.obolibrary.org/obo/MP_0009926 decreased transitional stage T2 B cell number absence of a type of transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, and is located in the splenic B follicles http://purl.obolibrary.org/obo/MP_0009928 abnormal pinna hair pigmentation http://purl.obolibrary.org/obo/MP_0002075 abnormal coat/hair pigmentation amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreased or increased in hair located behind the ears when compared to control animal pigmentation http://purl.obolibrary.org/obo/MP_0009929 meningomyelocele http://purl.obolibrary.org/obo/MP_0012547 spina bifida cystica hernial protrusion of the spinal cord and its meninges through an opening or defect in the vertebral column http://purl.obolibrary.org/obo/MP_0009930 fuzzy hair http://purl.obolibrary.org/obo/MP_0002074 abnormal hair texture covered with upright, fine, sometimes lightly curled hair http://purl.obolibrary.org/obo/MP_0009932 skin fibrosis http://purl.obolibrary.org/obo/MP_0002060 abnormal skin morphology invasion of fibrous connective tissue into the skin, often resulting from inflammation or injury http://purl.obolibrary.org/obo/MP_0009933 abnormal tail hair pigmentation http://purl.obolibrary.org/obo/MP_0002075 abnormal coat/hair pigmentation an anomaly in the expected coloration of hair on the dorsal and/or ventral surface of the tail http://purl.obolibrary.org/obo/MP_0009934 abnormal hind foot hair pigmentation http://purl.obolibrary.org/obo/MP_0002075 abnormal coat/hair pigmentation an anomaly in the expected color gradient of hair covering the metatarsals and phalanges often differentially expressed in females and males http://purl.obolibrary.org/obo/MP_0009935 abnormal Meibomian gland acinus morphology http://purl.obolibrary.org/obo/MP_0005252 abnormal Meibomian gland morphology any structural anomaly of the sac-like structures comprising the sebaceous glands located at the rim of the eyelids and responsible for producing sebum http://purl.obolibrary.org/obo/MP_0009936 abnormal dendritic spine morphology http://purl.obolibrary.org/obo/MP_0008143 abnormal dendrite morphology any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon http://purl.obolibrary.org/obo/MP_0009938 abnormal hippocampus granule cell morphology http://purl.obolibrary.org/obo/MP_0008285 abnormal hippocampus granule cell layer any structural anomaly of the small neurons of the hippocampal granule cell layer http://purl.obolibrary.org/obo/MP_0009940 abnormal hippocampus pyramidal cell morphology http://purl.obolibrary.org/obo/MP_0008284 abnormal hippocampus pyramidal cell layer any structural anomaly of a multipolar projection neuron in the hippocampus pyramidal cell layer; pyramidal cells have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base; the axons may have local collaterals but also project outside their cortical region http://purl.obolibrary.org/obo/MP_0009941 abnormal olfactory bulb interneuron morphology http://purl.obolibrary.org/obo/MP_0000965 abnormal sensory neuron morphology any structural anomaly of the group of neurons residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons http://purl.obolibrary.org/obo/MP_0009942 abnormal olfactory bulb granule cell morphology http://purl.obolibrary.org/obo/MP_0009949 abnormal olfactory bulb granule cell layer morphology any structural anomaly of the main intrinsic GABAergic neuron in the granule cell layer of the main olfactory bulb; dendrites of these cells receive synaptic input from mitral and tufted cell lateral dendrites in the external plexiform layer, and have synaptic outputs on those dendrites through reciprocal dendrodendritic synapses http://purl.obolibrary.org/obo/MP_0009943 abnormal olfactory bulb periglomerular cell morphology http://purl.obolibrary.org/obo/MP_0009948 abnormal olfactory bulb glomerular layer morphology any structural anomaly of the small neuron in the glomerular layer of the olfactory bulb whose dendrites arborize within a glomerulus, where it receives synaptic input from olfactory receptor cell axon terminals, and also engages in dendrodendritic interactions with mitral and tufted cell dendrites; uses both GABA and dopamine as a neurotransmitter http://purl.obolibrary.org/obo/MP_0009945 abnormal accessory olfactory bulb morphology http://purl.obolibrary.org/obo/MP_0009944 abnormal olfactory lobe morphology any structural anomaly of the forebrain region that coordinates sensory signaling arising from the vomeronasal organ; it is located on the dorsal-posterior portion of the main olfactory bulb, and the axons that leave the accessory olfactory bulb project to targets in the amygdala and hypothalamus http://purl.obolibrary.org/obo/MP_0009946 abnormal olfactory bulb layer morphology http://purl.obolibrary.org/obo/MP_0000819 abnormal olfactory bulb morphology any structural anomaly of the laminar structure of the forebrain region that coordinates neuronal signaling involved in the perception of smell http://purl.obolibrary.org/obo/MP_0009947 abnormal olfactory bulb external plexiform layer morphology http://purl.obolibrary.org/obo/MP_0009946 abnormal olfactory bulb layer morphology any structural anomaly of the part of the olfactory bulb, lying superior to the mitral cell layer and inferior to the glomerular layer, which is mostly neuropil composed almost entirely of mitral and tufted cell dendrites, granule cell dendrites and their synaptic inputs http://purl.obolibrary.org/obo/MP_0009952 abnormal olfactory bulb subventricular zone morphology http://purl.obolibrary.org/obo/MP_0004275 abnormal postnatal subventricular zone morphology any structural anomaly of the region of mitotically active layer of cells surrounding the lateral brain ventricles that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells, that produce neurons that migrate to the olfactory bulb http://purl.obolibrary.org/obo/MP_0009953 abnormal olfactory tubercle morphology http://purl.obolibrary.org/obo/MP_0005267 abnormal olfactory cortex morphology any structural anomaly of the region in the ventral telencephalon, prominent in rodents, but present in all mammals, consisting of a laminated cortical part and the cap/hilus region; it is traditionally viewed as part of the olfactory cortex but recognized by some as having a striatal character; according to many authors, the structure of the OT transitions from cortical like to striatal like along the lateral medial axis http://purl.obolibrary.org/obo/MP_0009954 abnormal mitral cell morphology http://purl.obolibrary.org/obo/MP_0009951 abnormal olfactory bulb mitral cell layer morphology any structural anomaly of the large glutaminergic nerve cells whose dendrites synapse with axons of the olfactory receptor neurons in the glomerular layer of the olfactory bulb, and whose axons pass centrally in the olfactory tract to the olfactory cortex http://purl.obolibrary.org/obo/MP_0009955 abnormal olfactory bulb tufted cell morphology http://purl.obolibrary.org/obo/MP_0009947 abnormal olfactory bulb external plexiform layer morphology any structural anomaly of the principal glutaminergic neuron located in the outer third of the external plexiform layer of the olfactory bulb; a single short primary dendrite traverses the outer external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches, where it receives the input from olfactory receptor neuron axon terminals; axons of the tufted cells transfer information to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala http://purl.obolibrary.org/obo/MP_0009957 abnormal cerebellum vermis lobule morphology http://purl.obolibrary.org/obo/MP_0009964 abnormal cerebellum lobule morphology any structural anomaly of the region of a cerebellar lobule that resides in the central section of the cerebellum between the two hemispheres; in humans, vermis lobule regions may be nearly continuous with the cerebellar hemisphere lobules dorsally but are separated by deeper longitudinal fissues in the ventral regions; in mammals, the vermis portion of the cerebellum has a foliation pattern along the AP axis that is distinct from the lateral cerebellar hemispheres http://purl.obolibrary.org/obo/MP_0009958 absent cerebellar granule cells http://purl.obolibrary.org/obo/MP_0008924 decreased cerebellar granule cell number absence of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites http://purl.obolibrary.org/obo/MP_0009959 abnormal cerebellar hemisphere morphology http://purl.obolibrary.org/obo/MP_0004097 abnormal cerebellar cortex morphology any structural anomaly of the paired regions of the cerebellum that lie outside and lateral to the central vermis http://purl.obolibrary.org/obo/MP_0009961 abnormal flocculonodular lobe morphology http://purl.obolibrary.org/obo/MP_0004097 abnormal cerebellar cortex morphology any structural anomaly of the small region of the cerebellum that is posterior to the posteriolateral fissure in humans; it receives input from the inferior and medial vestibular nuclei and sends fibers back to the vestibular nuclei, and processes and integrates these signals to allow for the constant maintenance of balance http://purl.obolibrary.org/obo/MP_0009963 abnormal cerebellum hemisphere lobule morphology http://purl.obolibrary.org/obo/MP_0009959 abnormal cerebellar hemisphere morphology any structural anomaly of the region of a cerebellar lobule that resides in either of the lateral sections of the cerebellum outside the vermis; in mammals, the vermis portion of the cerebellum has a foliation pattern along the AP axis that is distinct from the lateral cerebellar hemispheres; distinct species specific differences in hemisphere lobulation occurs among mammals, with greatest complexity in primates http://purl.obolibrary.org/obo/MP_0009965 abnormal cerebellum lateral hemisphere morphology http://purl.obolibrary.org/obo/MP_0009959 abnormal cerebellar hemisphere morphology any structural anomaly of the most lateral paired regions of the cerebellum; the lateral zone receives input from the parietal cortex via pontocerebellar mossy fibers regarding the location and position of the body and integrates input signals with indications of muscle activity http://purl.obolibrary.org/obo/MP_0009966 abnormal cerebellum intermediate hemisphere morphology http://purl.obolibrary.org/obo/MP_0009959 abnormal cerebellar hemisphere morphology any structural anomaly of the paired regions of the cerebellar hemisphere that lie adjacent to the vermis and are between the vermis and lateral regions of the hemispheres; it receives input from the corticopontocerebellar fibers that originate from the motor cortex, and also receives sensory feedback from the muscles; these signals are integrated by this region, to coordinate muscle activity with motor inputs http://purl.obolibrary.org/obo/MP_0009967 abnormal neuron proliferation http://purl.obolibrary.org/obo/MP_0004811 abnormal neuron physiology any anomaly in the ability of a neuron to undergo rapid expansion by cell division http://purl.obolibrary.org/obo/MP_0009968 abnormal cerebellar granule cell proliferation http://purl.obolibrary.org/obo/MP_0009967 abnormal neuron proliferation any anomaly in the ability of a cerebellar granule cell population to undergo rapid expansion by cell division http://purl.obolibrary.org/obo/MP_0009969 abnormal cerebral cortex pyramidal cell morphology http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex http://purl.obolibrary.org/obo/MP_0009970 increased hippocampus pyramidal cell number http://purl.obolibrary.org/obo/MP_0009940 abnormal hippocampus pyramidal cell morphology increased number of the multipolar projection neurons in the hippocampus pyramidal cell layer http://purl.obolibrary.org/obo/MP_0009971 decreased hippocampus pyramidal cell number http://purl.obolibrary.org/obo/MP_0009940 abnormal hippocampus pyramidal cell morphology decreased number of the multipolar projection neurons in the hippocampus pyramidal cell layer http://purl.obolibrary.org/obo/MP_0009972 absent hippocampus pyramidal cells http://purl.obolibrary.org/obo/MP_0009971 decreased hippocampus pyramidal cell number absence of the multipolar projection neurons in the hippocampus pyramidal cell layer http://purl.obolibrary.org/obo/MP_0009973 increased cerebral cortex pyramidal cell number http://purl.obolibrary.org/obo/MP_0009969 abnormal cerebral cortex pyramidal cell morphology increased number of the projection neurons in the pyramidal cell layer of the cerebral cortex http://purl.obolibrary.org/obo/MP_0009974 decreased cerebral cortex pyramidal cell number http://purl.obolibrary.org/obo/MP_0009969 abnormal cerebral cortex pyramidal cell morphology reduced number of the projection neurons in the pyramidal cell layer of the cerebral cortex http://purl.obolibrary.org/obo/MP_0009975 absent cerebral cortex pyramidal cells http://purl.obolibrary.org/obo/MP_0009974 decreased cerebral cortex pyramidal cell number absence of the projection neurons in the pyramidal cell layer of the cerebral cortex http://purl.obolibrary.org/obo/MP_0009976 abnormal cerebellar peduncle morphology http://purl.obolibrary.org/obo/MP_0009978 abnormal cerebellum white matter morphology any structural anomaly of any of the three large paired bundles of nerve fibers that connect the cerebellum to the brain stem http://purl.obolibrary.org/obo/MP_0009977 abnormal cerebellar granule cell migration http://purl.obolibrary.org/obo/MP_0006009 abnormal neuronal migration any anomaly in the movement of cerebellar granule cell neurons from the germinal zone into the granule cell layer of the cerebellum during development of the cerebellar cortex http://purl.obolibrary.org/obo/MP_0009979 abnormal cerebellum deep nucleus morphology http://purl.obolibrary.org/obo/MP_0000849 abnormal cerebellum morphology any structural anomaly of the gray matter nuclei located in the center of the cerebellum, embedded in the white matter, which receive inhibitory (GABAergic) inputs from Purkinje cells in the cerebellar cortex and excitatory (glutamatergic) inputs from mossy fiber pathways; all output fibers of the cerebellum originate from the these nuclei http://purl.obolibrary.org/obo/MP_0009980 abnormal cerebellum dentate nucleus morphology http://purl.obolibrary.org/obo/MP_0009979 abnormal cerebellum deep nucleus morphology any structural anomaly of the largest and most lateral of the deep cerebellum nuclei; it receives axons of Purkinje cells in the lateral cerebellar hemisphere (neocerebellum) and receives its afferents from the premotor cortex and the supplementary motor cortex through the pontocerebellar system, and its efferents project through the superior cerebellar peduncle and is a major source of its fibers http://purl.obolibrary.org/obo/MP_0009981 abnormal cerebellum emboliform nucleus morphology http://purl.obolibrary.org/obo/MP_0009984 abnormal cerebellum interpositus nucleus morphology any structural anomaly of the small wedge shaped nucleus interposed between the dentate and fastigial nuclei; it receives axons from Purkinje cells of the intermediate area of the cerebral hemispheres and most of its efferent connections travel via the superior cerebellar peduncle http://purl.obolibrary.org/obo/MP_0009982 abnormal cerebellum globose nucleus morphology http://purl.obolibrary.org/obo/MP_0009984 abnormal cerebellum interpositus nucleus morphology any structural anomaly of the two or three small masses of gray matter that is located medial to the emboliform nucleus and lateral to the fastigial nucleus; it receives axons from the intermediate area of the cerebellar hemispheres and its afferents exit through the superior cerebellar peduncle; it is recognized in human cerebellum but is not distinguishable in all mammalian species http://purl.obolibrary.org/obo/MP_0009983 abnormal cerebellum fastigial nucleus morphology http://purl.obolibrary.org/obo/MP_0009979 abnormal cerebellum deep nucleus morphology any structural anomaly of the most medial of the cerebellar nuclei; it receives its afferent input from Purkinje cells of the flocculonodular lobe and the vermis, and most of its efferent connections travel via the inferior cerebellar peduncle to the vestibular nuclei and to the medullary reticular formation http://purl.obolibrary.org/obo/MP_0009984 abnormal cerebellum interpositus nucleus morphology http://purl.obolibrary.org/obo/MP_0009979 abnormal cerebellum deep nucleus morphology any structural anomaly of the nucelus composed of the globose and emoliform nuclei of the cerebellum; in some mammalian species the globose nucleus is not distinguishable http://purl.obolibrary.org/obo/MP_0009985 abnormal inferior cerebellar peduncle morphology http://purl.obolibrary.org/obo/MP_0009976 abnormal cerebellar peduncle morphology any structural anomaly of the paired cerebellar peduncles that connects the medulla spinalis and medulla oblongata with the cerebellum, and is composed of juxtarestiform body and restiform body; it carries many types of input and output fibers that are mainly concerned with integrating proprioceptive sensory input with motor vestibular functions such as balance and posture maintenance http://purl.obolibrary.org/obo/MP_0009986 abnormal middle cerebellar peduncle morphology http://purl.obolibrary.org/obo/MP_0009976 abnormal cerebellar peduncle morphology any structural anomaly of the largest of the three paired cerebellar peduncles; it is composed mainly of afferent fibers that originate within the pontine nuclei as part of the massive corticopontocerebellar tract, whose fibers descend from the sensory and motor areas of the cerebral neocortex, through the pons and into the cerebellar nuclei and cortex http://purl.obolibrary.org/obo/MP_0009987 abnormal superior cerebellar peduncle morphology http://purl.obolibrary.org/obo/MP_0009976 abnormal cerebellar peduncle morphology any structural anomaly of the major output pathway of the cerebellum; most of the efferent fibers originate within the cerebellum dentate nucleus and cerebellum interpositus nuclei, which in turn project to various midbrain structures including the red nucleus, the ventral lateral/ventral anterior nucleus of the thalamus, and the medulla; most of the fibers that pass through this peduncle are involved in pathways important in motor planning http://purl.obolibrary.org/obo/MP_0010006 abnormal flocculus morphology http://purl.obolibrary.org/obo/MP_0009959 abnormal cerebellar hemisphere morphology any structural anomaly of the small region of the cerebellum that receives input from the inferior and medial vestibular nuclei and sends fibers back to the vestibular nuclei, and processes and integrates these signals to allow for the constant maintenance of balance http://purl.obolibrary.org/obo/MP_0010008 abnormal Purkinje cell migration http://purl.obolibrary.org/obo/MP_0006009 abnormal neuronal migration any anomaly in the movement of immature Purkinje cells from the ventricular zone of the fourth ventricle to the forming Purkinje cell layer during development of the cerebellar cortex http://purl.obolibrary.org/obo/MP_0010009 abnormal piriform cortex morphology http://purl.obolibrary.org/obo/MP_0005267 abnormal olfactory cortex morphology any structural anomaly of the subdivision of the laminated olfactory cortex with only three main layers that receive monosynaptic input from the olfactory bulb via the lateral olfactory tract; it is located bilaterally in the ventrolateral forebrain and is commonly divided into anterior and posterior regions http://purl.obolibrary.org/obo/MP_0010010 abnormal islands of Calleja morphology http://purl.obolibrary.org/obo/MP_0009953 abnormal olfactory tubercle morphology any structural anomaly of the seven small groups of granule cells in the polymorph layer of the olfactory tubercle and one large group, the insula magna, which lies along the border between septum, nucleus accumbens and nucleus of the diagonal band http://purl.obolibrary.org/obo/MP_0010011 ectopic hippocampus pyramidal cells http://purl.obolibrary.org/obo/MP_0009940 abnormal hippocampus pyramidal cell morphology the hippocampus pyramidal cell body resides in places other than the pyramidal cell layer of the hippocampus http://purl.obolibrary.org/obo/MP_0010012 ectopic cerebral cortex pyramidal cells http://purl.obolibrary.org/obo/MP_0009969 abnormal cerebral cortex pyramidal cell morphology the cerebral cortex pyramidal cell body resides in places other than the pyramidal cell layer of the cerebral cortex http://purl.obolibrary.org/obo/MP_0010013 cerebral cortex pyramidal cell degeneration http://purl.obolibrary.org/obo/MP_0009969 abnormal cerebral cortex pyramidal cell morphology a retrogressive impairment or destruction of the projection neuron in the pyramidal layer of the cerebral cortex http://purl.obolibrary.org/obo/MP_0010014 hippocampus pyramidal cell degeneration http://purl.obolibrary.org/obo/MP_0009940 abnormal hippocampus pyramidal cell morphology a retrogressive impairment or destruction of a multipolar projection neuron in the hippocampus pyramidal cell layer http://purl.obolibrary.org/obo/MP_0010015 abnormal cuticular plate morphology http://purl.obolibrary.org/obo/MP_0000042 abnormal organ of Corti morphology any structural anomaly of the firm laminar network of actin filaments in the organ of Corti to which the apical ends of the cochlear hair cells attach and through which their stereocilia project http://purl.obolibrary.org/obo/MP_0010016 variable depigmentation http://purl.obolibrary.org/obo/MP_0002095 abnormal skin pigmentation absence or loss of normal pigment in the skin in various and irregular patterns http://purl.obolibrary.org/obo/MP_0010018 pulmonary vascular congestion http://purl.obolibrary.org/obo/MP_0010017 visceral vascular congestion obstruction of the normal flux of blood within the blood vessel network of the lung resulting in engorgement of pulmonary vessels; frequently precedes pulmonary edema http://purl.obolibrary.org/obo/MP_0010019 liver vascular congestion http://purl.obolibrary.org/obo/MP_0009820 abnormal liver vasculature morphology obstruction of the normal flux of blood within the blood vessel network of the liver http://purl.obolibrary.org/obo/MP_0010020 spleen vascular congestion http://purl.obolibrary.org/obo/MP_0010017 visceral vascular congestion obstruction of the normal flux of blood within the blood vessel network of the spleen http://purl.obolibrary.org/obo/MP_0010021 heart vascular congestion http://purl.obolibrary.org/obo/MP_0010017 visceral vascular congestion obstruction of the normal flux of blood within the blood vessel network of the heart http://purl.obolibrary.org/obo/MP_0010022 brain vascular congestion http://purl.obolibrary.org/obo/MP_0004950 abnormal brain vasculature morphology obstruction of the normal flux of blood within the blood vessel network of the brain http://purl.obolibrary.org/obo/MP_0010023 cerebral vascular congestion http://purl.obolibrary.org/obo/MP_0010022 brain vascular congestion obstruction of the normal flux of blood within the blood vessel network of the cerebrum http://purl.obolibrary.org/obo/MP_0010024 increased total body fat amount http://purl.obolibrary.org/obo/MP_0012320 abnormal body fat mass greater than the normal total amount of connective tissue composed of fat cells within the entire body http://purl.obolibrary.org/obo/MP_0010025 decreased total body fat amount http://purl.obolibrary.org/obo/MP_0012320 abnormal body fat mass less than the normal total amount of connective tissue composed of fat cells within the entire body http://purl.obolibrary.org/obo/MP_0010026 decreased liver cholesterol level http://purl.obolibrary.org/obo/MP_0012776 abnormal liver cholesterol level less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues http://purl.obolibrary.org/obo/MP_0010027 increased liver cholesterol level http://purl.obolibrary.org/obo/MP_0012776 abnormal liver cholesterol level greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues http://purl.obolibrary.org/obo/MP_0010030 abnormal orbit morphology http://purl.obolibrary.org/obo/MP_0002092 abnormal eye morphology any structural anomaly of the bony ring that supports the eyeball and supporting tissues and is formed by parts of several cranial bones http://purl.obolibrary.org/obo/MP_0010032 meiotic drive http://purl.obolibrary.org/obo/MP_0001930 abnormal meiosis preferential production of gametes during meiosis (germ cell production), which alters the segregation of genes from the Mendelian expectations; meiotic drive is a mechanism for transmission distortion http://purl.obolibrary.org/obo/MP_0010033 paraphimosis http://purl.obolibrary.org/obo/MP_0005187 abnormal penis morphology inability of the penis to retract back into the prepuce/foreskin; entrapment of a retracted foreskin behind the coronal sulcus http://purl.obolibrary.org/obo/MP_0010034 abnormal erythrocyte clearance http://purl.obolibrary.org/obo/MP_0003656 abnormal erythrocyte physiology any anomaly in the selective elimination of aging erythrocytes from the body by autoregulatory mechanisms, often expressed as half-life http://purl.obolibrary.org/obo/MP_0010035 increased erythrocyte clearance http://purl.obolibrary.org/obo/MP_0010034 abnormal erythrocyte clearance increased elimination of aging erythrocytes from the body by autoregulatory mechanisms, often expressed as half-life http://purl.obolibrary.org/obo/MP_0010036 decreased erythrocyte clearance http://purl.obolibrary.org/obo/MP_0010034 abnormal erythrocyte clearance decreased elimination of aging erythrocytes from the body by autoregulatory mechanisms, often expressed as half-life http://purl.obolibrary.org/obo/MP_0010037 ectopic melanocytes http://purl.obolibrary.org/obo/MP_0002877 abnormal melanocyte morphology pigment producing cells are not located in the normal or expected position http://purl.obolibrary.org/obo/MP_0010039 abnormal trophoblast giant cell proliferation http://purl.obolibrary.org/obo/MP_0010038 abnormal placenta physiology abnormality in the expansion rate of the trophoblast giant cell population by cell division http://purl.obolibrary.org/obo/MP_0010040 abnormal oval cell morphology http://purl.obolibrary.org/obo/MP_0002138 abnormal hepatobiliary system morphology any structural anomaly of adult liver-specific stem cells; a blast-like cell capable of self renewal and multipotent differentiation, the oval cell is capable of differentiating into mature hepatocytes or cholangiocytes http://purl.obolibrary.org/obo/MP_0010041 absent oval cells http://purl.obolibrary.org/obo/MP_0010040 abnormal oval cell morphology absence of adult liver-specific stem cells; a blast-like cell capable of self renewal and multipotent differentiation, the oval cell is capable of differentiating into mature hepatocytes or cholangiocytes http://purl.obolibrary.org/obo/MP_0010042 abnormal oval cell physiology http://purl.obolibrary.org/obo/MP_0000609 abnormal liver physiology any functional anomaly of adult liver-specific stem cells; a blast-like cell capable of self renewal and multipotent differentiation, the oval cell is capable of differentiating into mature hepatocytes or cholangiocytes http://purl.obolibrary.org/obo/MP_0010043 abnormal frontonasal suture morphology http://purl.obolibrary.org/obo/MP_0002835 abnormal cranial suture morphology any structural anomaly of the dense, fibrous connective tissue joint between the frontal and nasal bones http://purl.obolibrary.org/obo/MP_0010044 abnormal omental fat pad morphology http://purl.obolibrary.org/obo/MP_0000010 abnormal abdominal fat pad morphology any structural anomaly of the encapsulated adipose tissue associated with the fold of peritoneal tissue that extends from the stomach to the posterior abdominal wall after associating with the transverse colon http://purl.obolibrary.org/obo/MP_0010045 increased omental fat pad weight http://purl.obolibrary.org/obo/MP_0010044 abnormal omental fat pad morphology greater than average weight of the encapsulated adipose tissue associated with the fold of peritoneal tissue that extends from the stomach to the posterior abdominal wall after associating with the transverse colon http://purl.obolibrary.org/obo/MP_0010046 decreased omental fat pad weight http://purl.obolibrary.org/obo/MP_0010044 abnormal omental fat pad morphology less than average weight of the encapsulated adipose tissue associated with the fold of peritoneal tissue that extends from the stomach to the posterior abdominal wall after associating with the transverse colon http://purl.obolibrary.org/obo/MP_0010047 axonal spheroids http://purl.obolibrary.org/obo/MP_0005405 axon degeneration focal 10-50 micron diameter swellings of axons, which are sometimes, but not always, terminal endbulbs, and are filled with disorganized neurofilaments, tubules, organelles or multi-lamellar inclusions http://purl.obolibrary.org/obo/MP_0010048 abnormal primitive streak regression http://purl.obolibrary.org/obo/MP_0002231 abnormal primitive streak morphology any anomaly in the process by which the primitive streak disappears during gastrulation, when the node moves back to a posterior position http://purl.obolibrary.org/obo/MP_0010050 hypermyelination http://purl.obolibrary.org/obo/MP_0000920 abnormal myelination increased myelin formation in a myelin sheath over all or part of an axon or fiber tract, usually resulting in a thicker myelin sheath http://purl.obolibrary.org/obo/MP_0010052 increased grip strength http://purl.obolibrary.org/obo/MP_0001515 abnormal grip strength greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire http://purl.obolibrary.org/obo/MP_0010053 decreased grip strength http://purl.obolibrary.org/obo/MP_0001515 abnormal grip strength reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire http://purl.obolibrary.org/obo/MP_0010054 increased hepatoblastoma incidence http://purl.obolibrary.org/obo/MP_0008021 increased blastoma incidence greater than the expected number of a malignant neoplasm occurring primarily in the liver and composed of tissue resembling embryonic or fetal hepatic epithelium, or mixed epithelial and mesenchymal tissues, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010056 ectopic skeletal muscle http://purl.obolibrary.org/obo/MP_0000759 abnormal skeletal muscle morphology skeletal muscle is located in a position not normally occupied by this tissue type http://purl.obolibrary.org/obo/MP_0010057 abnormal olfactory bulb outer nerve layer morphology http://purl.obolibrary.org/obo/MP_0009946 abnormal olfactory bulb layer morphology any structural anomaly of the outermost layer of the olfactory bulb; consists primarily of olfactory afferent axons and ensheathing glia http://purl.obolibrary.org/obo/MP_0010058 enlarged olfactory bulb http://purl.obolibrary.org/obo/MP_0000819 abnormal olfactory bulb morphology increased size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex http://purl.obolibrary.org/obo/MP_0010059 olfactory bulb hypoplasia http://purl.obolibrary.org/obo/MP_0002741 small olfactory bulb underdevelopment or reduced size, usually due to a reduced number of cells, of the forebrain region that coordinates neuronal signaling involved in the perception of smell http://purl.obolibrary.org/obo/MP_0010060 abnormal creatine level http://purl.obolibrary.org/obo/MP_0005332 abnormal amino acid level anomaly in the amount of the amino acid that is found in muscle tissue of vertebrates as phosphocreatine and supplies energy for muscle contraction when metabolized http://purl.obolibrary.org/obo/MP_0010061 increased creatine level http://purl.obolibrary.org/obo/MP_0010060 abnormal creatine level increase in the amount of the amino acid that is found in muscle tissue of vertebrates as phosphocreatine and supplies energy for muscle contraction when metabolized http://purl.obolibrary.org/obo/MP_0010062 decreased creatine level http://purl.obolibrary.org/obo/MP_0010060 abnormal creatine level reduction in the amount of the amino acid that is found in muscle tissue of vertebrates as phosphocreatine and supplies energy for muscle contraction when metabolized http://purl.obolibrary.org/obo/MP_0010063 abnormal circulating creatine level http://purl.obolibrary.org/obo/MP_0010060 abnormal creatine level anomaly in the amount per unit of blood of an amino acid that is found in muscle tissue of vertebrates as phosphocreatine and supplies energy for muscle contraction when metabolized http://purl.obolibrary.org/obo/MP_0010064 increased circulating creatine level http://purl.obolibrary.org/obo/MP_0010063 abnormal circulating creatine level increase in the amount per unit of blood of an amino acid that is found in muscle tissue of vertebrates as phosphocreatine and supplies energy for muscle contraction when metabolized http://purl.obolibrary.org/obo/MP_0010065 decreased circulating creatine level http://purl.obolibrary.org/obo/MP_0010063 abnormal circulating creatine level reduction in the amount per unit of blood of an amino acid that is found in muscle tissue of vertebrates as phosphocreatine and supplies energy for muscle contraction when metabolized http://purl.obolibrary.org/obo/MP_0010066 abnormal red blood cell distribution width http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology an anomaly in the coefficient of variance (reference range) of the red blood cell volume for an organism http://purl.obolibrary.org/obo/MP_0010068 decreased red blood cell distribution width http://purl.obolibrary.org/obo/MP_0010066 abnormal red blood cell distribution width lower than normal coefficient of variance (reference range) of the red blood cell volume for an organism http://purl.obolibrary.org/obo/MP_0010069 increased serotonin level http://purl.obolibrary.org/obo/MP_0005322 abnormal serotonin level increase in the amount of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity http://purl.obolibrary.org/obo/MP_0010070 decreased serotonin level http://purl.obolibrary.org/obo/MP_0005322 abnormal serotonin level reduction in the amount of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity http://purl.obolibrary.org/obo/MP_0010071 abnormal pruritus http://purl.obolibrary.org/obo/MP_0005501 abnormal skin physiology anomaly in the normal absence or presence of an uncomfortable sensation resulting from irritation of the skin or mucous membranes that evokes the desire or reflex to rub or scratch http://purl.obolibrary.org/obo/MP_0010072 increased pruritus http://purl.obolibrary.org/obo/MP_0010071 abnormal pruritus abnormal presence or increased intensity of an uncomfortable sensation resulting from irritation of the skin or mucous membranes that evokes the desire or reflex to rub or scratch http://purl.obolibrary.org/obo/MP_0010073 decreased pruritus http://purl.obolibrary.org/obo/MP_0010071 abnormal pruritus absence or decreased intensity of an uncomfortable sensation resulting from irritation of the skin or mucous membranes that evokes the desire or reflex to rub or scratch http://purl.obolibrary.org/obo/MP_0010074 stomatocytosis http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology deformation of red blood cells to a cup-like shape, with swelling and with an elongated area of central pallor, instead of the normal biconcave shape http://purl.obolibrary.org/obo/MP_0010075 abnormal circulating plant sterol level http://purl.obolibrary.org/obo/MP_0010076 abnormal plant sterol level anomaly in the amount of phytosterols in the blood http://purl.obolibrary.org/obo/MP_0010076 abnormal plant sterol level http://purl.obolibrary.org/obo/MP_0012224 abnormal sterol level anomaly in the amount of plant sterols often as a result of hyperabsorbtion of phytosterols and decreased biliary excretion of dietary sterols http://purl.obolibrary.org/obo/MP_0010077 increased plant sterol level http://purl.obolibrary.org/obo/MP_0010076 abnormal plant sterol level increased amount of plant sterols often as a result of hyperabsorbtion of phytosterols and decreased biliary excretion of dietary sterols http://purl.obolibrary.org/obo/MP_0010078 increased circulating plant sterol level http://purl.obolibrary.org/obo/MP_0010077 increased plant sterol level increase in the amount of phytosterols in the blood http://purl.obolibrary.org/obo/MP_0010079 increased osteochondroma incidence http://purl.obolibrary.org/obo/MP_0010280 increased skeletal tumor incidence greater than the expected number of a benign cartilagenous neoplasm that consists of a pedicle of normal bone capped by a region of proliferating cartilage cells, occurring in a specific population in a given time period; osteochondroma is most often associated with one or more of the long bones http://purl.obolibrary.org/obo/MP_0010081 posterior microphthalmia http://purl.obolibrary.org/obo/MP_0001297 microphthalmia reduced average size of the back of the eye http://purl.obolibrary.org/obo/MP_0010082 sternebra fusion http://purl.obolibrary.org/obo/MP_0004322 abnormal sternebra morphology appearance of one or more sternebrae as a single structure http://purl.obolibrary.org/obo/MP_0010084 abnormal long lived plasma cell morphology http://purl.obolibrary.org/obo/MP_0002439 abnormal plasma cell morphology any structural anomaly of a fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive; the majority of these cells of this type reside in the bone marrow http://purl.obolibrary.org/obo/MP_0010085 abnormal short lived plasma cell morphology http://purl.obolibrary.org/obo/MP_0002439 abnormal plasma cell morphology any structural anomaly of a fully differentiated plasma cell that lives for months, not years http://purl.obolibrary.org/obo/MP_0010086 abnormal circulating fructosamine level http://purl.obolibrary.org/obo/MP_0009642 abnormal blood homeostasis any anomaly in the concentration in the blood of total non enzymatic glycated proteins in the blood http://purl.obolibrary.org/obo/MP_0010087 increased circulating fructosamine level http://purl.obolibrary.org/obo/MP_0010086 abnormal circulating fructosamine level increase in the concentration in the blood of total non enzymatic glycated proteins in the blood http://purl.obolibrary.org/obo/MP_0010088 decreased circulating fructosamine level http://purl.obolibrary.org/obo/MP_0010086 abnormal circulating fructosamine level decrease in the concentration in the blood of total non enzymatic glycated proteins in the blood http://purl.obolibrary.org/obo/MP_0010089 abnormal circulating creatine kinase level http://purl.obolibrary.org/obo/MP_0020279 abnormal creatine kinase level any anomaly in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine http://purl.obolibrary.org/obo/MP_0010090 increased circulating creatine kinase level http://purl.obolibrary.org/obo/MP_0020280 increased creatine kinase level an elevation in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine http://purl.obolibrary.org/obo/MP_0010091 decreased circulating creatine kinase level http://purl.obolibrary.org/obo/MP_0020281 decreased creatine kinase level a reduction in the concentration in the blood of an enzyme that catalyzes the reversible transfer of creatine to phosphocreatine http://purl.obolibrary.org/obo/MP_0010092 increased circulating magnesium level http://purl.obolibrary.org/obo/MP_0001771 abnormal circulating magnesium level an elevation in the blood concentration of magnesium http://purl.obolibrary.org/obo/MP_0010093 decreased circulating magnesium level http://purl.obolibrary.org/obo/MP_0001771 abnormal circulating magnesium level a reduction in the blood concentration of magnesium http://purl.obolibrary.org/obo/MP_0010094 abnormal chromosome stability http://purl.obolibrary.org/obo/MP_0005621 abnormal cell physiology anomaly in the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an reduced rate of loss of heterozygosity http://purl.obolibrary.org/obo/MP_0010095 increased chromosomal stability http://purl.obolibrary.org/obo/MP_0010094 abnormal chromosome stability decrease in the probability that whole chromosomes or pieces of chromosomes are gained or lost during cell division, resulting in an imbalance in the number of chromosomes per cell (aneuploidy) and an reduced rate of loss of heterozygosity http://purl.obolibrary.org/obo/MP_0010096 abnormal incisor color http://purl.obolibrary.org/obo/MP_0013129 abnormal tooth color anomaly in the color and shading of the incisor, which normally presents in shades of white http://purl.obolibrary.org/obo/MP_0010097 abnormal retinal blood vessel morphology http://purl.obolibrary.org/obo/MP_0002792 abnormal retinal vasculature morphology any structural anomaly of the blood vessels supplying the retina http://purl.obolibrary.org/obo/MP_0010098 abnormal retinal blood vessel pattern http://purl.obolibrary.org/obo/MP_0002792 abnormal retinal vasculature morphology anomaly in the systematic arrangement of the blood vessels supplying the retina http://purl.obolibrary.org/obo/MP_0010099 abnormal thoracic cage shape http://purl.obolibrary.org/obo/MP_0004624 abnormal thoracic cage morphology anomaly in the overall regular dome shape of the ribcage http://purl.obolibrary.org/obo/MP_0010100 increased cervical vertebrae number http://purl.obolibrary.org/obo/MP_0003048 abnormal cervical vertebrae morphology increased number of the seven bony segments of the spine located anterior to the thoracic vertebrae and caudal to the skull http://purl.obolibrary.org/obo/MP_0010101 increased sacral vertebrae number http://purl.obolibrary.org/obo/MP_0004644 increased vertebrae number increase of any or all of the bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae http://purl.obolibrary.org/obo/MP_0010102 increased caudal vertebrae number http://purl.obolibrary.org/obo/MP_0004644 increased vertebrae number increased number of the bony segments of the coccyx or tail http://purl.obolibrary.org/obo/MP_0010103 small thoracic cage http://purl.obolibrary.org/obo/MP_0004624 abnormal thoracic cage morphology reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum http://purl.obolibrary.org/obo/MP_0010104 enlarged thoracic cage http://purl.obolibrary.org/obo/MP_0004624 abnormal thoracic cage morphology increased size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum http://purl.obolibrary.org/obo/MP_0010105 abnormal sublingual ganglion morphology http://purl.obolibrary.org/obo/MP_0001034 abnormal parasympathetic ganglion morphology any structural anomaly of the small parasympathetic ganglion found anterior to the submandibular gland that provides postsynaptic fibers to the sublingual gland http://purl.obolibrary.org/obo/MP_0010106 abnormal circulating pyruvate kinase level http://purl.obolibrary.org/obo/MP_0001570 abnormal circulating enzyme level abnormal concentration in the blood of the phosphotransferase in the glycolytic pathway that catalyzes the transfer of phosphate from phosphoenolpyruvate to ADP, forming ATP and p; deficiency results in hemolytic anemia http://purl.obolibrary.org/obo/MP_0010107 abnormal renal reabsorbtion http://purl.obolibrary.org/obo/MP_0002136 abnormal kidney physiology any anomaly in the two-step process beginning with the active or passive extraction of substances (such as water, glucose, oligopeptides, amino acids, sodium (Na+) and other ions) from the renal tubule fluid into the renal interstitium, and the subsequent transport of these substances out of the renal interstitium back into the bloodstream; reabsorbtion begins in the proximal convoluted tubules and continues in the loop of Henle, distal convoluted tubules, and collecting tubules http://purl.obolibrary.org/obo/MP_0010108 abnormal renal water reabsorbtion http://purl.obolibrary.org/obo/MP_0011443 abnormal renal water transport any anomaly in the process by which water is passively transported out of the renal tubules back into the bloodstream http://purl.obolibrary.org/obo/MP_0010109 abnormal renal sodium reabsorbtion http://purl.obolibrary.org/obo/MP_0011442 abnormal renal sodium ion transport any anomaly in the process by which sodium ions are transported out of the renal tubules back into the bloodstream http://purl.obolibrary.org/obo/MP_0010110 abnormal renal phosphate reabsorbtion http://purl.obolibrary.org/obo/MP_0010107 abnormal renal reabsorbtion any anomaly in the process by which phosphate (salt or ester of phosphoric acid) is transported out of the renal tubules back into the bloodstream http://purl.obolibrary.org/obo/MP_0010111 abnormal renal calcium reabsorbtion http://purl.obolibrary.org/obo/MP_0010107 abnormal renal reabsorbtion any anomaly in the process by which calcium ions are transported out of the renal tubules back into the bloodstream http://purl.obolibrary.org/obo/MP_0010112 abnormal coccygeal vertebrae morphology http://purl.obolibrary.org/obo/MP_0010114 abnormal coccyx morphology any structural anomaly of the 3-5 separate or fused bony segments of the coccyx http://purl.obolibrary.org/obo/MP_0010113 abnormal sacrum morphology http://purl.obolibrary.org/obo/MP_0004703 abnormal vertebral column morphology any structural anomaly of the segment of the vertebral column that is formed by the fusion of five sacral vertebrae in adult humans and tailless primates http://purl.obolibrary.org/obo/MP_0010114 abnormal coccyx morphology http://purl.obolibrary.org/obo/MP_0004703 abnormal vertebral column morphology any structural anomaly of the rostral-most segment of the vertebral column that is formed by the fusion of three to five coccygeal vertebrae in adult humans and tailless primates http://purl.obolibrary.org/obo/MP_0010116 abnormal primitive urogenital sinus morphology http://purl.obolibrary.org/obo/MP_0010115 abnormal embryonic cloaca morphology any structural anomaly of the ventral part of the cloaca remaining after septation of the rectum, which further develops into part of the bladder, part of the prostatic part of the male urethra and the urethra and vestibule in females http://purl.obolibrary.org/obo/MP_0010117 abnormal lateral plate mesoderm morphology http://purl.obolibrary.org/obo/MP_0001680 abnormal mesoderm development any structural anomaly of the portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures http://purl.obolibrary.org/obo/MP_0010118 abnormal intermediate mesoderm http://purl.obolibrary.org/obo/MP_0001680 abnormal mesoderm development any anomaly of the band of mesoderm located between the segmented paraxial mesoderm and the lateral plate mesoderm, that develops into the nephrogenic cord http://purl.obolibrary.org/obo/MP_0010122 abnormal bone mineral content http://purl.obolibrary.org/obo/MP_0003795 abnormal bone structure any anomaly in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area http://purl.obolibrary.org/obo/MP_0010123 increased bone mineral content http://purl.obolibrary.org/obo/MP_0010122 abnormal bone mineral content elevation in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area http://purl.obolibrary.org/obo/MP_0010124 decreased bone mineral content http://purl.obolibrary.org/obo/MP_0010122 abnormal bone mineral content reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area http://purl.obolibrary.org/obo/MP_0010125 abnormal parvocellular neurosecretory cell morphology http://purl.obolibrary.org/obo/MP_0010913 abnormal neuroendocrine cell morphology any structural anomaly of the secretory neurons of the paraventricular nucleus that synthesize and secrete vasopressin, corticotropin-releasing factor (CRF) and thyrotropin-releasing hormone (TRH) into blood vessels in the hypothalamo-pituitary portal system http://purl.obolibrary.org/obo/MP_0010126 abnormal distal visceral endoderm morphology http://purl.obolibrary.org/obo/MP_0011186 abnormal visceral endoderm morphology any structural anomaly of the precursors of the anterior visceral endoderm that arises at the distal tip of the embryo http://purl.obolibrary.org/obo/MP_0010127 hypervolemia http://purl.obolibrary.org/obo/MP_0001599 abnormal blood volume an abnormally increased amount of space occupied by blood in the vessels http://purl.obolibrary.org/obo/MP_0010128 hypovolemia http://purl.obolibrary.org/obo/MP_0001599 abnormal blood volume an abnormally decreased amount of space occupied by blood in the vessels http://purl.obolibrary.org/obo/MP_0010129 increased DN1 thymic pro-T cell number http://purl.obolibrary.org/obo/MP_0005090 increased double-negative T cell number increased number of pro-T cells that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative http://purl.obolibrary.org/obo/MP_0010130 decreased DN1 thymic pro-T cell number http://purl.obolibrary.org/obo/MP_0005089 decreased double-negative T cell number reduced number of pro-T cells that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative http://purl.obolibrary.org/obo/MP_0010131 increased DN2 thymocyte number http://purl.obolibrary.org/obo/MP_0005090 increased double-negative T cell number increased number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive http://purl.obolibrary.org/obo/MP_0010132 decreased DN2 thymocyte number http://purl.obolibrary.org/obo/MP_0005089 decreased double-negative T cell number reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive http://purl.obolibrary.org/obo/MP_0010133 increased DN3 thymocyte number http://purl.obolibrary.org/obo/MP_0005090 increased double-negative T cell number increased number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain. http://purl.obolibrary.org/obo/MP_0010134 decreased DN3 thymocyte number http://purl.obolibrary.org/obo/MP_0005089 decreased double-negative T cell number reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain. http://purl.obolibrary.org/obo/MP_0010135 increased DN4 thymocyte number http://purl.obolibrary.org/obo/MP_0005090 increased double-negative T cell number increased number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive. http://purl.obolibrary.org/obo/MP_0010136 decreased DN4 thymocyte number http://purl.obolibrary.org/obo/MP_0005089 decreased double-negative T cell number reduced number of thymocytes that have the cell surface marker phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive. http://purl.obolibrary.org/obo/MP_0010137 delayed exit from anagen phase http://purl.obolibrary.org/obo/MP_0008858 abnormal hair cycle anagen phase anomaly in the growth phase of the hair cycle resulting a prolonged anagen phase http://purl.obolibrary.org/obo/MP_0010138 arteritis http://purl.obolibrary.org/obo/MP_0001864 vasculitis inflammation of the walls of arteries, usually as a result of infection or auto-immune response http://purl.obolibrary.org/obo/MP_0010139 aortitis http://purl.obolibrary.org/obo/MP_0010138 arteritis inflammation of the aorta http://purl.obolibrary.org/obo/MP_0010140 phlebitis http://purl.obolibrary.org/obo/MP_0001864 vasculitis inflammation of a vein http://purl.obolibrary.org/obo/MP_0010141 lymphangitis http://purl.obolibrary.org/obo/MP_0001864 vasculitis inflammation of the lymphatic vessels/channels http://purl.obolibrary.org/obo/MP_0010142 disorganized hair shaft http://purl.obolibrary.org/obo/MP_0003809 abnormal hair shaft morphology derangement of the normal pattern of the layered structure of the cuticle, cortex and/or medulla of a hair http://purl.obolibrary.org/obo/MP_0010143 enhanced fertility http://purl.obolibrary.org/obo/MP_0002161 abnormal fertility/fecundity increased ability to produce live offspring http://purl.obolibrary.org/obo/MP_0010144 abnormal tumor vascularization http://purl.obolibrary.org/obo/MP_0010639 altered tumor pathology aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors http://purl.obolibrary.org/obo/MP_0010145 abnormal spermatic cord morphology http://purl.obolibrary.org/obo/MP_0009205 abnormal internal male genitalia morphology any structural anomaly of the cord-like structure in males comprising the vas deferens and associated tissue that runs from the abdomen down to each testis http://purl.obolibrary.org/obo/MP_0010146 umbilical hernia http://purl.obolibrary.org/obo/MP_0001725 abnormal umbilical cord morphology an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the umbilicus; occurs when the muscle through which blood vessels pass to feed the developing fetus fails to completely close http://purl.obolibrary.org/obo/MP_0010149 abnormal synaptic dopamine release http://purl.obolibrary.org/obo/MP_0005445 abnormal neurotransmitter secretion aberrant secretion across synapses of the catecholamine neurotransmitter and neurohormone, derived from tyrosine and the precursor to norepinephrine and epinephrine; functions as a neurotransmitter in the brain and as a hormone to inhibit the release of prolactin from the anterior lobe of the pituitary http://purl.obolibrary.org/obo/MP_0010150 abnormal mandibule ramus morphology http://purl.obolibrary.org/obo/MP_0000458 abnormal mandible morphology any structural anomaly of the upturned perpendicular extremity of the mandible http://purl.obolibrary.org/obo/MP_0010151 abnormal spinal cord ependymal layer morphology http://purl.obolibrary.org/obo/MP_0002653 abnormal ependyma morphology any structural anomaly of the cellular membrane that lines the central canal of the spinal cord http://purl.obolibrary.org/obo/MP_0010152 abnormal brain ependyma morphology http://purl.obolibrary.org/obo/MP_0002653 abnormal ependyma morphology any structural anomaly of the cellular membrane that lines the brain ventricles http://purl.obolibrary.org/obo/MP_0010153 abnormal gastroesophageal sphincter morphology http://purl.obolibrary.org/obo/MP_0010798 abnormal stomach cardiac region morphology any structural anomaly of the thick circular layer of smooth gastric musculature encircling the gastroesophageal junction that functions to reduce backflow into the esophagus from the stomach http://purl.obolibrary.org/obo/MP_0010156 abnormal small intestinal crypt cell physiology http://purl.obolibrary.org/obo/MP_0010155 abnormal intestine physiology any functional anomaly of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine http://purl.obolibrary.org/obo/MP_0010157 abnormal small intestinal crypt cell proliferation http://purl.obolibrary.org/obo/MP_0010156 abnormal small intestinal crypt cell physiology anomaly in the ability of the cells that make up the tubular intestinal glands found in the mucosal membranes of the small intestine to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0010159 abnormal enterocyte differentiation http://purl.obolibrary.org/obo/MP_0010158 abnormal intestine development abnormal formation of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen http://purl.obolibrary.org/obo/MP_0010160 increased oligodendrocyte number http://purl.obolibrary.org/obo/MP_0000953 abnormal oligodendrocyte morphology greater number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS http://purl.obolibrary.org/obo/MP_0010161 decreased brain cholesterol level http://purl.obolibrary.org/obo/MP_0012779 abnormal brain cholesterol level less than normal amount in the brain of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues http://purl.obolibrary.org/obo/MP_0010162 increased brain cholesterol level http://purl.obolibrary.org/obo/MP_0012779 abnormal brain cholesterol level greater than normal amount in the brain of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues http://purl.obolibrary.org/obo/MP_0010165 abnormal response to stress-induced hyperthermia http://purl.obolibrary.org/obo/MP_0011019 abnormal adaptive thermogenesis any anomaly in the expected increase in core body termperature in response to stress or anticipatory anxiety http://purl.obolibrary.org/obo/MP_0010166 increased response to stress-induced hyperthermia http://purl.obolibrary.org/obo/MP_0010165 abnormal response to stress-induced hyperthermia greater increase or faster than expected increase in core body termperature in response to stress or anticipatory anxiety http://purl.obolibrary.org/obo/MP_0010167 decreased response to stress-induced hyperthermia http://purl.obolibrary.org/obo/MP_0010165 abnormal response to stress-induced hyperthermia reduction or absence of the expected increase in core body termperature in response to stress or anticipatory anxiety http://purl.obolibrary.org/obo/MP_0010168 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number http://purl.obolibrary.org/obo/MP_0012773 abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number a greater number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release http://purl.obolibrary.org/obo/MP_0010169 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number http://purl.obolibrary.org/obo/MP_0012773 abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number a reduction in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release http://purl.obolibrary.org/obo/MP_0010170 abnormal glial cell apoptosis http://purl.obolibrary.org/obo/MP_0003690 abnormal glial cell physiology change in the timing or the number of glial cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0010171 abnormal centroacinar cell of Langerhans morphology http://purl.obolibrary.org/obo/MP_0009143 abnormal pancreatic duct morphology any structural anomaly of cells that line the pancreatic ducts that secrete mucins and an aqueous bicarbonate solution under stimulation by the hormone secretin http://purl.obolibrary.org/obo/MP_0010172 abnormal mammary gland epithelium physiology http://purl.obolibrary.org/obo/MP_0001881 abnormal mammary gland physiology any functional anomaly of the epithelial layer of the luminal surfaces of the mammary gland http://purl.obolibrary.org/obo/MP_0010173 increased mammary gland epithelium proliferation http://purl.obolibrary.org/obo/MP_0010172 abnormal mammary gland epithelium physiology increase in the expansion rate of the cells of the mammary gland epithelium by cell division http://purl.obolibrary.org/obo/MP_0010174 decreased mammary gland epithelium proliferation http://purl.obolibrary.org/obo/MP_0010172 abnormal mammary gland epithelium physiology decrease in the expansion rate of the cells of the mammary gland epithelium by cell division http://purl.obolibrary.org/obo/MP_0010175 leptocytosis http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology the presence of unusually thin or flattened red blood cells that when stained show a dark center and a peripheral ring of hemoglobin, separated by a pale unstained ring containing less hemoglobin, resulting in a bull's-eye appearance and resembling a 3D sombrero when viewed under EM; seen in certain anemias, thalassemias, hemoglobinopathies, obstructive jaundice, and the post-splenectomy state http://purl.obolibrary.org/obo/MP_0010176 dacryocytosis http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology presence of teardrop-shaped red blood cells http://purl.obolibrary.org/obo/MP_0010177 acanthocytosis http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology presence of erythrocytes characterized by multiple spiny (thorn-like) cytoplasmic projections http://purl.obolibrary.org/obo/MP_0010178 increased number of Howell-Jolly bodies http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology abnormal presence of basophilic nuclear remnants of condensed DNA (1 to 2 um in diameter) in circulating erythrocytes, typically seen in severe hemolytic anemias or after splenectomy; these inclusions are normally removed by the spleen but will persist in individuals with functional hyposplenia or asplenia http://purl.obolibrary.org/obo/MP_0010179 rough coat http://purl.obolibrary.org/obo/MP_0002074 abnormal hair texture coat does not have the usual smooth appearance http://purl.obolibrary.org/obo/MP_0010180 increased susceptibility to weight loss http://purl.obolibrary.org/obo/MP_0011118 abnormal susceptibility to weight loss greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction, infection or xenobiotic treatment http://purl.obolibrary.org/obo/MP_0010181 decreased susceptibility to weight loss http://purl.obolibrary.org/obo/MP_0011118 abnormal susceptibility to weight loss smaller decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction, infection or xenobiotic treatment http://purl.obolibrary.org/obo/MP_0010184 abnormal T follicular helper cell morphology http://purl.obolibrary.org/obo/MP_0010183 abnormal CD4-positive helper T cell morphology any structural anomaly of a CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production http://purl.obolibrary.org/obo/MP_0010185 abnormal T follicular helper cell number http://purl.obolibrary.org/obo/MP_0010184 abnormal T follicular helper cell morphology anomaly in the number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production http://purl.obolibrary.org/obo/MP_0010186 increased T follicular helper cell number http://purl.obolibrary.org/obo/MP_0010185 abnormal T follicular helper cell number greater number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production http://purl.obolibrary.org/obo/MP_0010187 decreased T follicular helper cell number http://purl.obolibrary.org/obo/MP_0010185 abnormal T follicular helper cell number reduced number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production http://purl.obolibrary.org/obo/MP_0010188 abnormal T follicular helper cell differentiation http://purl.obolibrary.org/obo/MP_0010184 abnormal T follicular helper cell morphology atypical production of or inability to produce the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production http://purl.obolibrary.org/obo/MP_0010189 abnormal T follicular helper cell physiology http://purl.obolibrary.org/obo/MP_0005463 abnormal CD4-positive, alpha-beta T cell physiology any functional anomaly of a CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production http://purl.obolibrary.org/obo/MP_0010190 abnormal retinal melanocyte morphology http://purl.obolibrary.org/obo/MP_0005103 abnormal retinal pigmentation any structural anomaly of the cells that produce pigment in the retina http://purl.obolibrary.org/obo/MP_0010191 abnormal choroid melanocyte morphology http://purl.obolibrary.org/obo/MP_0005100 abnormal choroid pigmentation any structural anomaly of the cells that produce pigment in the choroid http://purl.obolibrary.org/obo/MP_0010192 abnormal retinal melanin granule morphology http://purl.obolibrary.org/obo/MP_0010190 abnormal retinal melanocyte morphology any structural anomaly of the pigment particles in the retina http://purl.obolibrary.org/obo/MP_0010193 abnormal choroid melanin granule morphology http://purl.obolibrary.org/obo/MP_0010191 abnormal choroid melanocyte morphology any structural anomaly of the pigment particles in the choroid http://purl.obolibrary.org/obo/MP_0010194 absent lymphatic vessels http://purl.obolibrary.org/obo/MP_0001879 abnormal lymphatic vessel morphology absence of the network of vessels which carries lymph around the body http://purl.obolibrary.org/obo/MP_0010195 abnormal lymphatic vessel endothelium morphology http://purl.obolibrary.org/obo/MP_0001879 abnormal lymphatic vessel morphology any structural anomaly of the thin layer of flat cells that line the lymphatic vessels and form a barrier between circulating lymph in the lumen and the rest of the vessel wall http://purl.obolibrary.org/obo/MP_0010196 abnormal lymphatic vessel smooth muscle morphology http://purl.obolibrary.org/obo/MP_0001879 abnormal lymphatic vessel morphology any structural anomaly of the nonstriated, involuntary muscle tissue that encompasses the lymphatic vessels http://purl.obolibrary.org/obo/MP_0010197 abnormal lymphatic vessel endothelial cell morphology http://purl.obolibrary.org/obo/MP_0010195 abnormal lymphatic vessel endothelium morphology any structural anomaly of the cells that line the lymphatic vessels http://purl.obolibrary.org/obo/MP_0010198 decreased lymphatic vessel endothelial cell number http://purl.obolibrary.org/obo/MP_0010197 abnormal lymphatic vessel endothelial cell morphology reduced number of the cells that line the lymphatic vessels http://purl.obolibrary.org/obo/MP_0010199 absent lymphatic vessel endothelial cells http://purl.obolibrary.org/obo/MP_0010198 decreased lymphatic vessel endothelial cell number absence of the cells that line the lymphatic vessels http://purl.obolibrary.org/obo/MP_0010202 focal dorsal hair loss http://purl.obolibrary.org/obo/MP_0000418 focal hair loss focal hair loss on the dorsal area of a rodent resulting in dorsal skin visible in a patch where hair loss occurs http://purl.obolibrary.org/obo/MP_0010203 focal ventral hair loss http://purl.obolibrary.org/obo/MP_0000418 focal hair loss focal hair loss on the ventral area of a rodent resulting in ventral skin visible in a patch where hair loss occurs http://purl.obolibrary.org/obo/MP_0010204 abnormal astrocyte apoptosis http://purl.obolibrary.org/obo/MP_0010170 abnormal glial cell apoptosis change in the timing or the number of astrocytes undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0010205 abnormal oligodendrocyte apoptosis http://purl.obolibrary.org/obo/MP_0010170 abnormal glial cell apoptosis change in the timing or the number of oligodendrocytes undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0010206 pigment incontinence http://purl.obolibrary.org/obo/MP_0002095 abnormal skin pigmentation absence of melanin and melanosomes in the epidermis, and accumulation of melanin and melanosome in melanophages in the upper dermis http://purl.obolibrary.org/obo/MP_0010208 prognathia http://purl.obolibrary.org/obo/MP_0000454 abnormal jaw morphology abnormal protrusion of the mandible relative to the facial skeleton and soft tissues http://purl.obolibrary.org/obo/MP_0010209 abnormal circulating chemokine level http://purl.obolibrary.org/obo/MP_0010210 abnormal circulating cytokine level deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes in the circulation http://purl.obolibrary.org/obo/MP_0010210 abnormal circulating cytokine level http://purl.obolibrary.org/obo/MP_0008713 abnormal cytokine level deviation from the normal levels in the blood of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells http://purl.obolibrary.org/obo/MP_0010211 abnormal acute phase protein level http://purl.obolibrary.org/obo/MP_0008469 abnormal protein level deviation from the normal levels of the series of proteins found in the blood shortly after infection and which participate in the early phases of host defense against infection http://purl.obolibrary.org/obo/MP_0010212 abnormal circulating C-reactive protein level http://purl.obolibrary.org/obo/MP_0010211 abnormal acute phase protein level deviation from the normal levels of the plasma protein that circulates in increased amounts during inflammation or after tissue damage and binds to phosphocholine expressed on the surface of dead or dying cells, including all types of pneumococci, in order to activate the complement system via the C1Q complex http://purl.obolibrary.org/obo/MP_0010213 abnormal circulating fibrinogen level http://purl.obolibrary.org/obo/MP_0010211 abnormal acute phase protein level deviation from the normal levels in the blood of a globulin that is converted into fibrin by the action of thrombin in the presence of ionized calcium to produce coagulation of the blood http://purl.obolibrary.org/obo/MP_0010214 abnormal circulating serum amyloid protein level http://purl.obolibrary.org/obo/MP_0010211 abnormal acute phase protein level deviation from the normal blood levels of an acute-phase reaction protein that is a precursor to amyloid A protein; it is present in very high levels during acute inflammatory episodes, and is present in low concentrations in normal sera, but is found at higher concentrations in sera of older persons and in patients with amyloidosis http://purl.obolibrary.org/obo/MP_0010215 abnormal circulating complement protein level http://purl.obolibrary.org/obo/MP_0011566 abnormal complement protein level deviation from the normal levels of the serum proteins that act sequentially to allow for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes http://purl.obolibrary.org/obo/MP_0010216 abnormal circulating retinol binding protein level http://purl.obolibrary.org/obo/MP_0005416 abnormal circulating protein level anomaly in the blood level of carrier proteins that bind retinol; serum levels are used to detect liver disease, protein-calorie malnutrition and vitamin A deficiencies http://purl.obolibrary.org/obo/MP_0010217 abnormal T-helper 17 cell morphology http://purl.obolibrary.org/obo/MP_0010183 abnormal CD4-positive helper T cell morphology any structural anomaly of a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17 http://purl.obolibrary.org/obo/MP_0010218 abnormal T-helper 17 cell number http://purl.obolibrary.org/obo/MP_0010217 abnormal T-helper 17 cell morphology deviation from the normal count of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17 http://purl.obolibrary.org/obo/MP_0010219 increased T-helper 17 cell number http://purl.obolibrary.org/obo/MP_0010218 abnormal T-helper 17 cell number increased number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17 http://purl.obolibrary.org/obo/MP_0010220 decreased T-helper 17 cell number http://purl.obolibrary.org/obo/MP_0010218 abnormal T-helper 17 cell number reduced number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17 http://purl.obolibrary.org/obo/MP_0010221 abnormal T-helper 17 cell differentiation http://purl.obolibrary.org/obo/MP_0010217 abnormal T-helper 17 cell morphology atypical production of or inability to produce the CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17 http://purl.obolibrary.org/obo/MP_0010222 abnormal T-helper 17 cell physiology http://purl.obolibrary.org/obo/MP_0005463 abnormal CD4-positive, alpha-beta T cell physiology any functional anomaly of a CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive that produces IL-17 http://purl.obolibrary.org/obo/MP_0010223 abnormal immunoglobulin transcytosis http://purl.obolibrary.org/obo/MP_0001790 abnormal immune system physiology any anomaly in the process of transporting immunoglobulin, via transcytosis, from one side of a cell to the other; occurs in epithelial cells and other cell types http://purl.obolibrary.org/obo/MP_0010224 abnormal heart ventricle outflow tract morphology http://purl.obolibrary.org/obo/MP_0005294 abnormal heart ventricle morphology any structural anomaly of the superior portion of the ventricles of the heart through which blood flows into the arteries http://purl.obolibrary.org/obo/MP_0010225 abnormal quadriceps morphology http://purl.obolibrary.org/obo/MP_0003358 abnormal hypaxial muscle morphology any structural anomaly of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint http://purl.obolibrary.org/obo/MP_0010226 increased quadriceps weight http://purl.obolibrary.org/obo/MP_0020164 abnormal quadriceps weight increase in the weight of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint http://purl.obolibrary.org/obo/MP_0010227 decreased quadriceps weight http://purl.obolibrary.org/obo/MP_0020164 abnormal quadriceps weight reduction in the weight of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint http://purl.obolibrary.org/obo/MP_0010228 decreased transitional stage T3 B cell number http://purl.obolibrary.org/obo/MP_0009921 abnormal transitional stage T3 B cell morphology reduced number of a type of a transitional stage B cell that expresses surface IgM and IgD, and CD62L; it is an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, and CD62L-positive http://purl.obolibrary.org/obo/MP_0010229 increased transitional stage T3 B cell number http://purl.obolibrary.org/obo/MP_0009921 abnormal transitional stage T3 B cell morphology greater number of a type of a transitional stage B cell that expresses surface IgM and IgD, and CD62L; it is an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, and CD62L-positive http://purl.obolibrary.org/obo/MP_0010230 absent transitional stage T3 B cells http://purl.obolibrary.org/obo/MP_0010228 decreased transitional stage T3 B cell number absence of a type of a transitional stage B cell that expresses surface IgM and IgD, and CD62L; it is an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, and CD62L-positive http://purl.obolibrary.org/obo/MP_0010231 transverse fur striping http://purl.obolibrary.org/obo/MP_0009659 striated fur presence of stripes of pigmented hair, usually black, of variable degree and location in the coat http://purl.obolibrary.org/obo/MP_0010232 delayed skin pigmentation appearance http://purl.obolibrary.org/obo/MP_0002095 abnormal skin pigmentation lag in the time that normal coloration of the skin color occurs in relation to control animals http://purl.obolibrary.org/obo/MP_0010233 hairless tail http://purl.obolibrary.org/obo/MP_0002111 abnormal tail morphology the tail is devoid of hair http://purl.obolibrary.org/obo/MP_0010234 abnormal vibrissa follicle morphology http://purl.obolibrary.org/obo/MP_0010678 abnormal skin adnexa morphology any structural anomaly of one of the tubular invaginations of the epidermis enclosing the hair roots and from which grow the vibrissae located on the muzzle and face of many species http://purl.obolibrary.org/obo/MP_0010235 abnormal retina inner limiting membrane morphology http://purl.obolibrary.org/obo/MP_0001325 abnormal retina morphology any structural anomaly of the row of fused Muller cell processes and astrocytes that separates the retinal nerve fiber layer from the vitreous http://purl.obolibrary.org/obo/MP_0010236 abnormal retina outer limiting membrane morphology http://purl.obolibrary.org/obo/MP_0001325 abnormal retina morphology any structural anomaly of the row of junctional complexes between the plasma membranes of rod segments and the Muller glia cells; this barrier separates the layer of inner and outer segments of the rods and cones from the outer nuclear layer and forms a blood-retina barrier http://purl.obolibrary.org/obo/MP_0010237 abnormal skeletal muscle weight http://purl.obolibrary.org/obo/MP_0009458 abnormal skeletal muscle size any anomaly in the average skeletal muscle weight http://purl.obolibrary.org/obo/MP_0010238 increased skeletal muscle weight http://purl.obolibrary.org/obo/MP_0010237 abnormal skeletal muscle weight greater than average skeletal muscle weight http://purl.obolibrary.org/obo/MP_0010239 decreased skeletal muscle weight http://purl.obolibrary.org/obo/MP_0010240 decreased skeletal muscle size less than average skeletal muscle weight http://purl.obolibrary.org/obo/MP_0010240 decreased skeletal muscle size http://purl.obolibrary.org/obo/MP_0004819 decreased skeletal muscle mass less than average dimensions of one or more of the muscles of the skeleton http://purl.obolibrary.org/obo/MP_0010241 abnormal aortic arch development http://purl.obolibrary.org/obo/MP_0004113 abnormal aortic arch morphology anomaly in the process of forming the convex portion of the aorta between the ascending and descending parts of the aorta; including formation of the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery http://purl.obolibrary.org/obo/MP_0010242 abnormal kidney copper level http://purl.obolibrary.org/obo/MP_0003952 abnormal copper level an anomaly in the amount of copper present in kidney tissue http://purl.obolibrary.org/obo/MP_0010243 increased kidney copper level http://purl.obolibrary.org/obo/MP_0010242 abnormal kidney copper level a greater accumulation of copper in the kidney tissue compared to controls http://purl.obolibrary.org/obo/MP_0010244 decreased kidney copper level http://purl.obolibrary.org/obo/MP_0010242 abnormal kidney copper level a reduced amount of copper in the kidney tissue compared to controls http://purl.obolibrary.org/obo/MP_0010245 abnormal spleen perifollicular zone morphology http://purl.obolibrary.org/obo/MP_0000689 abnormal spleen morphology any structural anomaly of the compartment located between the marginal zone and the red pulp harboring scattered B and T lymphocytes http://purl.obolibrary.org/obo/MP_0010246 abnormal intestine copper level http://purl.obolibrary.org/obo/MP_0003952 abnormal copper level an anomaly in the amount of copper present in the intestine http://purl.obolibrary.org/obo/MP_0010247 increased intestine copper level http://purl.obolibrary.org/obo/MP_0010246 abnormal intestine copper level a greater accumulation of copper in intestinal tissue compared with controls http://purl.obolibrary.org/obo/MP_0010248 decreased intestine copper level http://purl.obolibrary.org/obo/MP_0010246 abnormal intestine copper level a reduced amount of copper in the intestinal tissue compared to controls http://purl.obolibrary.org/obo/MP_0010249 lactation failure http://purl.obolibrary.org/obo/MP_0001882 abnormal lactation mammary glands do not secrete milk after parturition http://purl.obolibrary.org/obo/MP_0010250 absent thymus cortex http://purl.obolibrary.org/obo/MP_0002371 abnormal thymus cortex morphology lacking the outer part of the thymus lobule which surrounds the medulla and is normally composed of closely packed lymphocytes http://purl.obolibrary.org/obo/MP_0010251 subcapsular cataracts http://purl.obolibrary.org/obo/MP_0001304 cataracts a lens opacity localized beneath the anterior or posterior lens capsule http://purl.obolibrary.org/obo/MP_0010252 anterior subcapsular cataracts http://purl.obolibrary.org/obo/MP_0010251 subcapsular cataracts a lens opacity localized beneath the anterior lens capsule http://purl.obolibrary.org/obo/MP_0010253 posterior subcapsular cataracts http://purl.obolibrary.org/obo/MP_0010251 subcapsular cataracts a lens opacity localized beneath the posterior lens capsule http://purl.obolibrary.org/obo/MP_0010254 nuclear cataracts http://purl.obolibrary.org/obo/MP_0001304 cataracts a lens opacity located in the dense, central part of the lens http://purl.obolibrary.org/obo/MP_0010255 cortical cataracts http://purl.obolibrary.org/obo/MP_0001304 cataracts a lens opacity, frequently punctate, affecting the lens cortex in which spokes or wedges progressively extend from the outside of the lens towards the center http://purl.obolibrary.org/obo/MP_0010256 anterior cortical cataracts http://purl.obolibrary.org/obo/MP_0010255 cortical cataracts a lens opacity, frequently punctate, affecting the anterior pole of the lens cortex in which spokes or wedges progressively extend from the outside of the lens towards the center http://purl.obolibrary.org/obo/MP_0010257 posterior cortical cataracts http://purl.obolibrary.org/obo/MP_0010255 cortical cataracts a lens opacity, frequently punctate, affecting the posterior pole of the lens cortex in which spokes or wedges progressively extend from the outside of the lens towards the center http://purl.obolibrary.org/obo/MP_0010258 polar cataracts http://purl.obolibrary.org/obo/MP_0001304 cataracts a lens opacity, usually disk-shaped, that is limited to an area in the anterior or posterior pole of the lens capsular region http://purl.obolibrary.org/obo/MP_0010259 anterior polar cataracts http://purl.obolibrary.org/obo/MP_0010258 polar cataracts a lens opacity, usually disk-shaped, that is limited to an area in the anterior pole of the lens capsular region http://purl.obolibrary.org/obo/MP_0010260 posterior polar cataracts http://purl.obolibrary.org/obo/MP_0010258 polar cataracts a lens opacity, usually disk-shaped, that is limited to an area in the posterior pole of the lens capsular region http://purl.obolibrary.org/obo/MP_0010261 sutural cataracts http://purl.obolibrary.org/obo/MP_0001304 cataracts a lens opacity which follows the shape of anterior or posterior Y suture of the fetal lens and is not progressive; often more severe in males and is congenital, but usually does not affect vision http://purl.obolibrary.org/obo/MP_0010262 lamellar cataracts http://purl.obolibrary.org/obo/MP_0001304 cataracts a concentric lens opacity which is limited to layers of the cortex, affecting one lamella or zonule of an otherwise clear lens; usually congenital http://purl.obolibrary.org/obo/MP_0010263 total cataracts http://purl.obolibrary.org/obo/MP_0001304 cataracts a lens opacity which involves both nuclear and cortical regions, including all fibers of a lens; usually congenital http://purl.obolibrary.org/obo/MP_0010264 increased hepatoma incidence http://purl.obolibrary.org/obo/MP_0008019 increased liver tumor incidence greater than the expected number of malignant tumors composed of neoplastic liver cells in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010265 decreased hepatoma incidence http://purl.obolibrary.org/obo/MP_0010266 decreased liver tumor incidence less than the expected number of malignant tumors composed of neoplastic liver cells in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010266 decreased liver tumor incidence http://purl.obolibrary.org/obo/MP_0012421 decreased hepatobiliary system tumor incidence less than the expected number of neoplams in the liver, usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010267 decreased lung tumor incidence http://purl.obolibrary.org/obo/MP_0010282 decreased organ/body region tumor incidence less than the expected number of neoplams in the lung, usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010268 decreased lymphoma incidence http://purl.obolibrary.org/obo/MP_0010283 decreased classified tumor incidence less than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010269 decreased mammary gland tumor incidence http://purl.obolibrary.org/obo/MP_0012422 decreased integument system tumor incidence less than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010270 decreased stomach tumor incidence http://purl.obolibrary.org/obo/MP_0012424 decreased alimentary system tumor incidence less than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010271 decreased tongue tumor incidence http://purl.obolibrary.org/obo/MP_0012424 decreased alimentary system tumor incidence less than the expected number of neoplasms in the tongue tissue, usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010272 increased tongue tumor incidence http://purl.obolibrary.org/obo/MP_0003750 increased mouth tumor incidence greater than the expected number of neoplasms in the tongue tissue, usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010274 increased organ/body region tumor incidence http://purl.obolibrary.org/obo/MP_0013152 abnormal organ/body region tumor incidence greater than the expected number of tumors originating in a specific body region or organ in a given population in a given time period http://purl.obolibrary.org/obo/MP_0010275 increased melanoma incidence http://purl.obolibrary.org/obo/MP_0002018 increased malignant tumor incidence greater than the expected number of malignant neoplasms, derived from melanocytes and occurring in pigmented tissues, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010276 increased intraocular melanoma incidence http://purl.obolibrary.org/obo/MP_0010302 increased uvea tumor incidence greater than the expected number of a dark-pigmented, usually malignant tumor arising from a melanocyte in the uvea of the eye, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010277 increased astrocytoma incidence http://purl.obolibrary.org/obo/MP_0010278 increased glioma incidence greater than the expected number of tumors that arise from astrocytes, large neuroglia cells of nervous tissue, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010278 increased glioma incidence http://purl.obolibrary.org/obo/MP_0010281 increased nervous system tumor incidence greater than the expected number of tumors that arise from glial cells, non-neuronal cells of the nervous tissue, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010282 decreased organ/body region tumor incidence http://purl.obolibrary.org/obo/MP_0013152 abnormal organ/body region tumor incidence less than the expected number of tumors originating in a specific body region or organ in a given population in a given time period http://purl.obolibrary.org/obo/MP_0010283 decreased classified tumor incidence http://purl.obolibrary.org/obo/MP_0020188 abnormal classified tumor incidence less than the expected number of tumors with a specific classification type in a given population in a given time period http://purl.obolibrary.org/obo/MP_0010284 decreased plasmacytoma incidence http://purl.obolibrary.org/obo/MP_0010283 decreased classified tumor incidence less han the expected number of neoplastic plasma cells in bone or in one of the extramedullary sites occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010285 decreased skin tumor incidence http://purl.obolibrary.org/obo/MP_0012422 decreased integument system tumor incidence less than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010286 increased plasmacytoma incidence http://purl.obolibrary.org/obo/MP_0010273 increased classified tumor incidence greater than the expected number of neoplastic plasma cells in bone or in one of the extramedullary sites occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010289 increased urinary system tumor incidence http://purl.obolibrary.org/obo/MP_0010274 increased organ/body region tumor incidence greater than the expected number of tumors originating in the urinary system in a given population in a given time period http://purl.obolibrary.org/obo/MP_0010293 increased integument system tumor incidence http://purl.obolibrary.org/obo/MP_0010274 increased organ/body region tumor incidence greater than the expected number of tumors originating in the integument system in a given population in a given time period http://purl.obolibrary.org/obo/MP_0010295 increased eye tumor incidence http://purl.obolibrary.org/obo/MP_0010274 increased organ/body region tumor incidence greater than the expected number of tumors originating in the eye in a given population in a given time period http://purl.obolibrary.org/obo/MP_0010297 increased hepatobiliary system tumor incidence http://purl.obolibrary.org/obo/MP_0010274 increased organ/body region tumor incidence greater than the expected number of tumors originating in the hepatobiliary system in a given population in a given time period http://purl.obolibrary.org/obo/MP_0010298 increased respiratory system tumor incidence http://purl.obolibrary.org/obo/MP_0010274 increased organ/body region tumor incidence greater than the expected number of tumors originating in the respiratory system in a given population in a given time period http://purl.obolibrary.org/obo/MP_0010301 increased stomach tumor incidence http://purl.obolibrary.org/obo/MP_0010279 increased gastrointestinal tumor incidence greater than the expected number of neoplasms in the gastric tissue usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010302 increased uvea tumor incidence http://purl.obolibrary.org/obo/MP_0010295 increased eye tumor incidence greater than the expected number of neoplasms in the uvea, usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010303 increased retina tumor incidence http://purl.obolibrary.org/obo/MP_0010295 increased eye tumor incidence greater than the expected number of neoplasms in the retina, usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010304 increased choroid tumor incidence http://purl.obolibrary.org/obo/MP_0010302 increased uvea tumor incidence greater than the expected number of neoplasms in the choroid of the eye, usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010305 increased iris tumor incidence http://purl.obolibrary.org/obo/MP_0010302 increased uvea tumor incidence greater than the expected number of neoplasms in the iris of the eye, usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010307 abnormal tumor latency http://purl.obolibrary.org/obo/MP_0002166 altered tumor susceptibility anomaly in the expected time of onset of tumor occurrence http://purl.obolibrary.org/obo/MP_0010308 decreased tumor latency http://purl.obolibrary.org/obo/MP_0010307 abnormal tumor latency earlier onset of tumor occurrence than expected http://purl.obolibrary.org/obo/MP_0010309 increased mesothelioma incidence http://purl.obolibrary.org/obo/MP_0010273 increased classified tumor incidence greater than the expected number of neoplasms derived from the lining cells of the pleura and peritoneum, in a specific population in a given time period; is composed of spindle cells or fibrous tissue which may enclose glandlike spaces lined by cuboidal cells http://purl.obolibrary.org/obo/MP_0010310 increased Schwannoma incidence http://purl.obolibrary.org/obo/MP_0010281 increased nervous system tumor incidence greater than the expected number of benign, encapsulated nerve sheath tumors composed of Schwann cells, in a specific population in a given time period; usually associated with a peripheral or cranial nerve http://purl.obolibrary.org/obo/MP_0010311 increased meningioma incidence http://purl.obolibrary.org/obo/MP_0010281 increased nervous system tumor incidence greater than the expected number of encapsulated neoplasms derived from the meninges, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010312 increased oligodendroglioma incidence http://purl.obolibrary.org/obo/MP_0010278 increased glioma incidence greater than the expected number of encapsulated neoplasms derived from oligodendrocytes, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010313 increased osteoma incidence http://purl.obolibrary.org/obo/MP_0010280 increased skeletal tumor incidence greater than the expected number of benign neoplasms derived from lamellar bone, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010314 increased neurofibroma incidence http://purl.obolibrary.org/obo/MP_0010281 increased nervous system tumor incidence greater than the expected number of benign, encapsulated nerve sheath tumors composed of Schwann cells, in a specific population in a given time period; proliferation is disordered and includes portions of nerve fibers http://purl.obolibrary.org/obo/MP_0010315 increased cholangiocarcinoma incidence http://purl.obolibrary.org/obo/MP_0010297 increased hepatobiliary system tumor incidence greater than the expected number of malignant adenocarcimomas arising in the intrahepatic bile duct epithelium, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010317 increased parotid gland tumor incidence http://purl.obolibrary.org/obo/MP_0010318 increased salivary gland tumor incidence greater than the expected number of neoplams in the parotid gland occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010319 increased submandibular gland tumor incidence http://purl.obolibrary.org/obo/MP_0010318 increased salivary gland tumor incidence greater than the expected number of neoplams in the submandibular gland occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010322 increased cutaneous melanoma incidence http://purl.obolibrary.org/obo/MP_0010275 increased melanoma incidence greater than the expected number of a dark-pigmented, usually malignant tumor arising from a melanocyte in the skin, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010323 retropulsion http://purl.obolibrary.org/obo/MP_0003313 abnormal locomotor activation a tendency to step or walk backwards http://purl.obolibrary.org/obo/MP_0010325 abnormal malleus head morphology http://purl.obolibrary.org/obo/MP_0000029 abnormal malleus morphology any structural anomaly of the rounded portion of the malleus articulating with the body of the incus http://purl.obolibrary.org/obo/MP_0010326 malleus hypoplasia http://purl.obolibrary.org/obo/MP_0008372 small malleus underdevelopment or reduced size, usually due to a reduced number of cells, of the largest of the three auditory ossicles, which resembles a club or hammer http://purl.obolibrary.org/obo/MP_0010327 abnormal malleus neck morphology http://purl.obolibrary.org/obo/MP_0000029 abnormal malleus morphology any structural anomaly of the narrow contracted section of the malleus located between the head and the manubrium http://purl.obolibrary.org/obo/MP_0010328 thin malleus neck http://purl.obolibrary.org/obo/MP_0010327 abnormal malleus neck morphology smaller diameter of the narrow contracted section of the malleus located between the head and the manubrium http://purl.obolibrary.org/obo/MP_0010329 abnormal lipoprotein level http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis any anomaly in the concentrations of any complex or compound containing both lipid and protein, are important components of biological membranes and myelin, and participate in lipid transport http://purl.obolibrary.org/obo/MP_0010331 abnormal apolipoprotein level http://purl.obolibrary.org/obo/MP_0008469 abnormal protein level anomaly in the amount of the a protein that is frequently a component of a lipoprotein complex http://purl.obolibrary.org/obo/MP_0010332 abnormal circulating apolipoprotein level http://purl.obolibrary.org/obo/MP_0010331 abnormal apolipoprotein level anomaly in the amount in the blood of a protein that is frequently a component of a lipoprotein complex http://purl.obolibrary.org/obo/MP_0010333 abnormal circulating apolipoprotein E level http://purl.obolibrary.org/obo/MP_0010332 abnormal circulating apolipoprotein level anomaly in the amount in the blood of a protein that is frequently a component of a VLDL, HDL, and chylomicron complexes, and functions in cholesterol transport http://purl.obolibrary.org/obo/MP_0010335 fused first pharyngeal arch http://purl.obolibrary.org/obo/MP_0006337 abnormal first pharyngeal arch morphology the first arch fails to fully divide along the midline http://purl.obolibrary.org/obo/MP_0010338 increased desmoid tumor incidence http://purl.obolibrary.org/obo/MP_0003580 increased fibroma incidence greater than the expected number of a monoclonal, fibroblastic proliferation arising in musculoaponeurotic structures in a specific population in a given time period; this connective tissue hyperplasia infiltrates locally, recurs frequently after resection but does not metastasize; this tumor may occur at the site of any fascia, but in particular in muscle http://purl.obolibrary.org/obo/MP_0010339 increased cardiac fibroma incidence http://purl.obolibrary.org/obo/MP_0010291 increased cardiovascular system tumor incidence greater than the expected number of a benign tumor of fibrous or fully developed connective tissue in the cardiac tissue, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010340 increased lung fibroma incidence http://purl.obolibrary.org/obo/MP_0008014 increased lung tumor incidence greater than the expected number of a benign tumor of fibrous or fully developed connective tissue in the lung, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010341 increased mammary gland fibroma incidence http://purl.obolibrary.org/obo/MP_0010299 increased mammary gland tumor incidence greater than the expected number of a benign tumor of fibrous or fully developed connective tissue in the mammary gland, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010342 increased facial angiofibroma incidence http://purl.obolibrary.org/obo/MP_0008018 increased facial tumor incidence greater than the expected number of a benign tumor of fibrous or fully developed connective tissue on the face, in a specific population in a given time period; appear as red or yellow papules containing dilated vascular channels http://purl.obolibrary.org/obo/MP_0010343 increased lipoma incidence http://purl.obolibrary.org/obo/MP_0010273 increased classified tumor incidence greater than the expected number of a benign neoplasia derived from lipoblasts or lipocytes of white or brown fat, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010344 increased hibernoma incidence http://purl.obolibrary.org/obo/MP_0010343 increased lipoma incidence greater than the expected number of a benign neoplasm derived from brown fat occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010345 increased thyroid C-cell carcinoma incidence http://purl.obolibrary.org/obo/MP_0010346 increased thyroid carcinoma incidence greater than the expected number of a malignant neoplasm derived from the calcitonin producing C-cells of the thyroid gland, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010346 increased thyroid carcinoma incidence http://purl.obolibrary.org/obo/MP_0010316 increased thyroid tumor incidence greater than the expected number of a malignant epithelial neoplasms of the thyroid gland, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010347 osseous metaplasia http://purl.obolibrary.org/obo/MP_0003448 altered tumor morphology the formation of mature bone elements in the stroma of a neoplasm http://purl.obolibrary.org/obo/MP_0010348 increased pancreatic islet cell carcinoma incidence http://purl.obolibrary.org/obo/MP_0009153 increased pancreas tumor incidence greater than the expected number of malignant neoplasms arising in the pancreatic islet cells, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010349 increased teratocarcinoma incidence http://purl.obolibrary.org/obo/MP_0002627 increased teratoma incidence greater than the expected number of a mixed germ cell neoplasm contaning elements of embryonal carcinoma and teratoma, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010351 increased pituitary melanotroph tumor incidence http://purl.obolibrary.org/obo/MP_0010320 increased pituitary gland tumor incidence greater than the expected number of neoplasms derived from the cells of intermediate pituitary that produce melanocyte stimulating hormone and other peptides from the post-translational processing of pro-opiomelanocortin (POMC) http://purl.obolibrary.org/obo/MP_0010353 increased odontoma incidence http://purl.obolibrary.org/obo/MP_0010273 increased classified tumor incidence greater than the expected number of a hamartomatous odontogenic tumor composed of enamel, dentin, cementum, and pulp tissue that may or may not be arranged in the form of a tooth, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010354 increased odontosarcoma incidence http://purl.obolibrary.org/obo/MP_0010353 increased odontoma incidence greater than the expected number of an a gnathic malignant connective tissue tumor in which the epithelial component is benign and the proliferative mesenchymal component is malignant, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010355 abnormal first pharyngeal arch artery morphology http://purl.obolibrary.org/obo/MP_0006337 abnormal first pharyngeal arch morphology any structural anomaly of the vessels formed within the first pair of branchial arches in embryogenesis http://purl.obolibrary.org/obo/MP_0010356 abnormal second pharyngeal arch artery morphology http://purl.obolibrary.org/obo/MP_0006338 abnormal second pharyngeal arch morphology any structural anomaly of the vessels formed within the second pair of branchial arches in embryogenesis http://purl.obolibrary.org/obo/MP_0010357 increased prostate gland tumor incidence http://purl.obolibrary.org/obo/MP_0010288 increased gland tumor incidence greater than the expected number of neoplams in the prostate gland occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010359 increased liver free fatty acids level http://purl.obolibrary.org/obo/MP_0010358 abnormal free fatty acids level elevated liver concentrations of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues http://purl.obolibrary.org/obo/MP_0010360 decreased liver free fatty acids level http://purl.obolibrary.org/obo/MP_0010358 abnormal free fatty acids level reduced liver concentration of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues http://purl.obolibrary.org/obo/MP_0010361 increased gangliosarcoma incidence http://purl.obolibrary.org/obo/MP_0010281 increased nervous system tumor incidence greater than the expected number of a highly aggressive malignant neoplasm arising from mature ganglionic neurons, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010362 increased ganglioneuroma incidence http://purl.obolibrary.org/obo/MP_0010281 increased nervous system tumor incidence greater than the expected number of a benign neoplasm composed of mature ganglionic neurons in a given population in a given time period; cells may be scattered singly or in clumps within a relatively abundant and dense stroma of neurofibrils and collagenous fibers http://purl.obolibrary.org/obo/MP_0010364 increased fibroadenoma incidence http://purl.obolibrary.org/obo/MP_0010299 increased mammary gland tumor incidence greater than the expected number of a benign mammary gland tumor composed of both fibrous tissue and glandular tissue, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010366 increased adrenal cortical tumor incidence http://purl.obolibrary.org/obo/MP_0002031 increased adrenal gland tumor incidence greater than the expected number of neoplams in the adrenal cortex occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010367 increased spindle cell carcinoma incidence http://purl.obolibrary.org/obo/MP_0002038 increased carcinoma incidence greater than the expected number of a highly malignant variant of squamous cell carcinoma, occurring in a specific population in a given time period; spindle cell carcinoma shows biphasic proliferation of conventional SCC component and malignant spindle shape cells with sarcomatous appearance http://purl.obolibrary.org/obo/MP_0010369 abnormal thalamus neuron morphology http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology any structural anomaly of the impulse-conducting cells in the thalamus or its parts, a midline paired symmetrical structure between the cerebral cortex and midbrain within the brain that controls the flow of information to the cortex http://purl.obolibrary.org/obo/MP_0010370 abnormal throat morphology http://purl.obolibrary.org/obo/MP_0000462 abnormal digestive system morphology any structural anomaly in the anterior part of the neck, in front of the vertebral column comprising the pharynx and larynx http://purl.obolibrary.org/obo/MP_0010371 abnormal epiglottis morphology http://purl.obolibrary.org/obo/MP_0010370 abnormal throat morphology any structural anomaly of the most superior of the laryngeal cartilages, which is found at the root of the tongue and folds back over the entrance to the larynx during swallowing, preventing inhalation of food or drink http://purl.obolibrary.org/obo/MP_0010372 throat cyst http://purl.obolibrary.org/obo/MP_0010370 abnormal throat morphology presence of fluid-filled usually benign growths in the passage from the mouth to the pharynx http://purl.obolibrary.org/obo/MP_0010373 myeloid hyperplasia http://purl.obolibrary.org/obo/MP_0008250 abnormal myeloid leukocyte morphology greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue http://purl.obolibrary.org/obo/MP_0010374 bilirubinate stones http://purl.obolibrary.org/obo/MP_0002830 gallstones caliculi in the gallbladder or a bile duct that is composed of calcium bilirubinate http://purl.obolibrary.org/obo/MP_0010375 increased kidney iron level http://purl.obolibrary.org/obo/MP_0008742 abnormal kidney iron level increase in the amount of iron present in the renal tissue http://purl.obolibrary.org/obo/MP_0010376 decreased kidney iron level http://purl.obolibrary.org/obo/MP_0008742 abnormal kidney iron level reduction in the amount of iron present in the renal tissue http://purl.obolibrary.org/obo/MP_0010377 abnormal gut flora balance http://purl.obolibrary.org/obo/MP_0001663 abnormal digestive system physiology anomaly in the ratio of microorganisms that live in the digestive tracts of animals, many of which perform symbiotic functions to the host http://purl.obolibrary.org/obo/MP_0010378 increased respiratory quotient http://purl.obolibrary.org/obo/MP_0004129 abnormal respiratory quotient increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls http://purl.obolibrary.org/obo/MP_0010379 decreased respiratory quotient http://purl.obolibrary.org/obo/MP_0004129 abnormal respiratory quotient reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls http://purl.obolibrary.org/obo/MP_0010380 abnormal inner cell mass apoptosis http://purl.obolibrary.org/obo/MP_0008932 abnormal embryonic tissue physiology the cells of the blastocyst that develop into the body of the embryo are undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0010381 abnormal dosage compensation http://purl.obolibrary.org/obo/MP_0012167 abnormal epigenetic regulation of gene expression anomaly in the process of compensating for the two-fold variation in X:autosome chromosome ratios between sexes by a global activation or inactivation of all, or most of, genes on one or both of the X chromosomes http://purl.obolibrary.org/obo/MP_0010382 abnormal dosage compensation, by inactivation of X chromosome http://purl.obolibrary.org/obo/MP_0010381 abnormal dosage compensation anomaly in the process of compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex http://purl.obolibrary.org/obo/MP_0010384 increased renal carcinoma incidence http://purl.obolibrary.org/obo/MP_0010294 increased kidney tumor incidence greater than the expected number of malignant neoplasms arising from kidney epithelial tissue, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010385 abnormal glycinergic neuron morphology http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology any structural anomaly of the neurons that utilize glycine as a neurotransmitter http://purl.obolibrary.org/obo/MP_0010388 abnormal Bergmann glial cell differentiation http://purl.obolibrary.org/obo/MP_0010387 abnormal Bergmann glial cell morphology abnormal formation of the astrocyte-type glia cells associated with Purkinje cells in the cerebellum http://purl.obolibrary.org/obo/MP_0010389 mosaic coat color http://purl.obolibrary.org/obo/MP_0005366 variegated coat color a random coat color pattern due to genetically different populations of cells in the skin e.g. as the result of X-inactivation http://purl.obolibrary.org/obo/MP_0010390 increased adrenocortical adenoma incidence http://purl.obolibrary.org/obo/MP_0010366 increased adrenal cortical tumor incidence greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the adrenal cortex, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010391 increased rhabdomyoma incidence http://purl.obolibrary.org/obo/MP_0010290 increased muscle tumor incidence greater than the expected number of a benign neoplasm derived from striated muscle and comprised of an encapsulated mass of polygonal cells, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0010392 prolonged QRS complex duration http://purl.obolibrary.org/obo/MP_0010636 bundle branch block increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart http://purl.obolibrary.org/obo/MP_0010393 shortened QRS complex duration http://purl.obolibrary.org/obo/MP_0003898 abnormal QRS complex decrease in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart http://purl.obolibrary.org/obo/MP_0010394 decreased QRS amplitude http://purl.obolibrary.org/obo/MP_0003898 abnormal QRS complex reduction in the size (height or maximum displacement) of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction, suggesting ventricular excitation defects http://purl.obolibrary.org/obo/MP_0010395 abnormal pharyngeal arch development http://purl.obolibrary.org/obo/MP_0002884 abnormal pharyngeal arch morphology abnormal formation of the of the transient structures of the embryo that develop into regions of the head, neck and ears http://purl.obolibrary.org/obo/MP_0010396 ectopic pharyngeal arch http://purl.obolibrary.org/obo/MP_0002884 abnormal pharyngeal arch morphology abnormal location of any of the transient structures of the embryo resulting in misplaced regions of the head, neck and/or ears http://purl.obolibrary.org/obo/MP_0010397 abnormal otic capsule development http://purl.obolibrary.org/obo/MP_0006030 abnormal otic vesicle development any anomaly in the embryonic cartilage covering that surrounds the inner ear mechanism and develops into bone http://purl.obolibrary.org/obo/MP_0010398 decreased liver glycogen level http://purl.obolibrary.org/obo/MP_0012777 abnormal liver glycogen level less than the normal concentration of a readily converted carbohydrate reserve in liver http://purl.obolibrary.org/obo/MP_0010399 decreased skeletal muscle glycogen level http://purl.obolibrary.org/obo/MP_0005439 decreased glycogen level less than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle http://purl.obolibrary.org/obo/MP_0010400 increased liver glycogen level http://purl.obolibrary.org/obo/MP_0012777 abnormal liver glycogen level greater than the normal concentration of a readily converted carbohydrate reserve in liver http://purl.obolibrary.org/obo/MP_0010401 increased skeletal muscle glycogen level http://purl.obolibrary.org/obo/MP_0005440 increased glycogen level greater than the normal concentration of a readily converted carbohydrate reserve in skeletal muscle http://purl.obolibrary.org/obo/MP_0010402 ventricular septal defect http://purl.obolibrary.org/obo/MP_0000281 abnormal interventricular septum morphology abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions http://purl.obolibrary.org/obo/MP_0010403 atrial septal defect http://purl.obolibrary.org/obo/MP_0000282 abnormal interatrial septum morphology abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions http://purl.obolibrary.org/obo/MP_0010404 ostium primum atrial septal defect http://purl.obolibrary.org/obo/MP_0010403 atrial septal defect interatrial communication (atrial septal defect) through the most anterior and inferior aspect of the atrial septum http://purl.obolibrary.org/obo/MP_0010405 ostium secundum atrial septal defect http://purl.obolibrary.org/obo/MP_0010403 atrial septal defect large interatrial communication (atrial septal defect) through the center of the wall between the atria at the site of the foramen ovale and the ostium secundum http://purl.obolibrary.org/obo/MP_0010406 common atrium http://purl.obolibrary.org/obo/MP_0010403 atrial septal defect absence of the thin membranous structure between the two heart atria, resulting in the appearance of one upper chamber http://purl.obolibrary.org/obo/MP_0010407 coronary sinus atrial septal defect http://purl.obolibrary.org/obo/MP_0010403 atrial septal defect interatrial communication (atrial septal defect) through coronary sinus orifice, that is characterized by the absence of at least a portion of the common wall that separates the coronary sinus and the left atrium; interatrial shunting occurs through the defect in the wall on the left atrial side, which is continuous with the orifice of the coronary sinus opening on the right atrial side of the septum http://purl.obolibrary.org/obo/MP_0010408 sinus venosus atrial septal defect http://purl.obolibrary.org/obo/MP_0010403 atrial septal defect interatrial communication (atrial septal defect) through the upper atrial septum and that is contiguous with the superior vena cava (SVC); it is rostral and posterior to the fossa ovalis (where secundum type defects occur) and is separate from it http://purl.obolibrary.org/obo/MP_0010409 cor triatriatum http://purl.obolibrary.org/obo/MP_0003105 abnormal heart atrium morphology a heart with 3 atria, is in which either the left or right atrium is divided into 2 parts by a fold of tissue, a membrane, or a fibromuscular band that may vary significantly in size and shape, appearing similar to a diaphragm or funnel-shaped, bandlike, entirely intact (imperforate) or contain 1 or more openings (fenestrations) ranging from small, restrictive-type to large and widely open http://purl.obolibrary.org/obo/MP_0010410 cor triatriatum sinistrum http://purl.obolibrary.org/obo/MP_0010409 cor triatriatum a heart with 3 atria, is in which the left atrium is divided into 2 parts by a fold of tissue, a membrane, or a fibromuscular band http://purl.obolibrary.org/obo/MP_0010411 cor triatriatum dextrum http://purl.obolibrary.org/obo/MP_0010409 cor triatriatum a heart with 3 atria, is in which the right atrium is divided into 2 parts by a fold of tissue, a membrane, or a fibromuscular band http://purl.obolibrary.org/obo/MP_0010412 atrioventricular septal defect http://purl.obolibrary.org/obo/MP_0010592 abnormal atrioventricular septum morphology defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD) http://purl.obolibrary.org/obo/MP_0010413 complete atrioventricular septal defect http://purl.obolibrary.org/obo/MP_0010412 atrioventricular septal defect a type of atrioventricular septal defect in which a single atrioventricular valve annulus, a common atrioventricular valve, and a defect of the inlet ventricular septum are observed; deficiency of the atrioventricular septum also results in the presence of a large primum atrial septal defect http://purl.obolibrary.org/obo/MP_0010414 partial atrioventricular septal defect http://purl.obolibrary.org/obo/MP_0010412 atrioventricular septal defect a type of atrioventricular septal defect in which the endocardial cushion defects present have an interatrial communication but lack an interventricular communication; the mitral and tricuspid annuli are separate but one or more additional features are present, including primum atrial septal defect (ASD), inlet ventricular septal defect (VSD), cleft of the anterior mitral valve leaflet, and wide anteroseptal tricuspid valve commissure or cleft septal tricuspid leaflet http://purl.obolibrary.org/obo/MP_0010415 intermediate atrioventricular septal defect http://purl.obolibrary.org/obo/MP_0010412 atrioventricular septal defect a type of atrioventricular septal defect in which a partial AVSD is present together with a small interventricular communication; a single valvar annulus is usually present where the anterior and posterior bridging leaflets fuse overlying the ventricular septum, with two distinct valvar components observed http://purl.obolibrary.org/obo/MP_0010416 interventricular septum membranous part aneurysm http://purl.obolibrary.org/obo/MP_0010421 ventricular aneurysm a a saclike thinning, stretching and widening of the ventricular membranous septum resulting from weakening of the membraneous septum wall http://purl.obolibrary.org/obo/MP_0010417 subarterial ventricular septal defect http://purl.obolibrary.org/obo/MP_0010402 ventricular septal defect abnormal communications between the two lower chambers of the heart, located beneath the pulmonic valve, communicating with the RV outflow tract above the supraventricular crest, and are associated with aortic regurgitation secondary to the prolapse of the right aortic cusp http://purl.obolibrary.org/obo/MP_0010418 perimembraneous ventricular septal defect http://purl.obolibrary.org/obo/MP_0010402 ventricular septal defect abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect http://purl.obolibrary.org/obo/MP_0010419 inlet ventricular septal defect http://purl.obolibrary.org/obo/MP_0010402 ventricular septal defect abnormal communications between the two lower chambers of the heart, located posterior to the septal leaflet of the tricuspid valve and which are not associated with defects of the atrioventricular valves http://purl.obolibrary.org/obo/MP_0010420 muscular ventricular septal defect http://purl.obolibrary.org/obo/MP_0010498 abnormal interventricular septum muscular part morphology abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect http://purl.obolibrary.org/obo/MP_0010421 ventricular aneurysm http://purl.obolibrary.org/obo/MP_0005294 abnormal heart ventricle morphology thinning, stretching and bulging of a weakened ventricular wall http://purl.obolibrary.org/obo/MP_0010422 heart right ventricle hypoplasia http://purl.obolibrary.org/obo/MP_0003649 decreased heart right ventricle size underdevelopment or reduced size of the heart right ventricle, often due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0010423 heart right ventricle aneurysm http://purl.obolibrary.org/obo/MP_0010421 ventricular aneurysm thinning, stretching and bulging of a weakened heart right ventricular wall http://purl.obolibrary.org/obo/MP_0010424 double chambered heart right ventricle http://purl.obolibrary.org/obo/MP_0003920 abnormal heart right ventricle morphology septated right ventricle caused by the presence of abnormally located or hypertrophied cardiac muscle bands that divide the ventricular cavity into a proximal and a distal chamber; the muscle bundles typically run between an area located in the ventricular septum, beneath the level of the septal leaflet of the tricuspid valve, and the anterior wall of the right ventricle http://purl.obolibrary.org/obo/MP_0010425 abnormal heart and great vessel attachment http://purl.obolibrary.org/obo/MP_0000266 abnormal heart morphology any anomaly in the in the position or pattern of the connection site of the heart to any of the primary vessels, including the superior vena cavae, inferior vena cavae, pulmonary artery, pulmonary veins, and aorta http://purl.obolibrary.org/obo/MP_0010427 double outlet left ventricle http://purl.obolibrary.org/obo/MP_0010426 abnormal heart and great artery attachment both the aorta and the pulmonary trunk originate from the left ventricle http://purl.obolibrary.org/obo/MP_0010430 total anomalous pulmonary venous connection, supracardiac http://purl.obolibrary.org/obo/MP_0010441 total anomalous pulmonary venous connection the pulmonary veins drain via a common vein into the right superior vena cava, left superior vena cava, or their tributaries instead of the left atrium http://purl.obolibrary.org/obo/MP_0010431 atrial situs inversus http://purl.obolibrary.org/obo/MP_0006065 abnormal heart position or orientation anomaly in the asymmetry of the cardiac atria such that atria on both the left and right side have the morphology normally seen on the opposite side of the body http://purl.obolibrary.org/obo/MP_0010432 common ventricle http://purl.obolibrary.org/obo/MP_0000281 abnormal interventricular septum morphology the presence of only one working lower chamber in the heart, usually with a virtual absence of the ventricular septum and usually present in conjunction with double inlet left or right ventricle http://purl.obolibrary.org/obo/MP_0010433 double inlet heart left ventricle http://purl.obolibrary.org/obo/MP_0010435 abnormal heart atrium and ventricle connection congenital heart defect in which both atriums are connected to the left ventricle, with a hypoplastic right ventricle often present, which may be on the opposite side of the heart http://purl.obolibrary.org/obo/MP_0010434 double inlet heart right ventricle http://purl.obolibrary.org/obo/MP_0010435 abnormal heart atrium and ventricle connection congenital heart defect in which both atriums are connected to the right ventricle, with a hypoplastic left ventricle often present http://purl.obolibrary.org/obo/MP_0010436 abnormal coronary sinus morphology http://purl.obolibrary.org/obo/MP_0010551 abnormal coronary vessel morphology any structural anomaly of the short trunk that recieves most of the cardiac veins carrying the blood from the myocardium and delivers it to the right atrium, with the sinoatrial connection occurring between the inferior vena cava and the atrioventricular orifice http://purl.obolibrary.org/obo/MP_0010437 absent coronary sinus http://purl.obolibrary.org/obo/MP_0010436 abnormal coronary sinus morphology absence of the short trunk that recieves most of the cardiac veins carrying the blood from the myocardium and delivers it to the right atrium http://purl.obolibrary.org/obo/MP_0010438 pulmonary vein stenosis http://purl.obolibrary.org/obo/MP_0005412 vascular stenosis a stricture or occlusion of the lumen of the pulmonary vein http://purl.obolibrary.org/obo/MP_0010439 abnormal hepatic vein morphology http://purl.obolibrary.org/obo/MP_0002725 abnormal vein morphology any structural anomaly of the veins that drain blood from the liver and terminate in three large openings to the inferior vena cava below the diaphragm and into smaller openings in more inferior positions http://purl.obolibrary.org/obo/MP_0010440 anomalous pulmonary venous connection http://purl.obolibrary.org/obo/MP_0010425 abnormal heart and great vessel attachment abnormal development and attachment of the four pulmonary veins that normally attach to the left atrium of the heart, resulting in either partial or complete anomalous drainage back into the systemic venous circulation via an anomalous connection to the right atrium, the superior or inferior vena cava, the innominate vein, the coronary sinus or the left subclavian artery http://purl.obolibrary.org/obo/MP_0010441 total anomalous pulmonary venous connection http://purl.obolibrary.org/obo/MP_0010440 anomalous pulmonary venous connection abnormal development and attachment of all four pulmonary veins that normally attach to the left atrium of the heart, resulting in complete anomalous drainage back into the systemic venous circulation via an anomalous connection to the right atrium, the superior or inferior vena cava, the innominate vein, the coronary sinus or the left subclavian artery; in TAPVC, none of the four pulmonary veins are attached to the left atrium http://purl.obolibrary.org/obo/MP_0010442 partial anomalous pulmonary venous connection http://purl.obolibrary.org/obo/MP_0010440 anomalous pulmonary venous connection abnormal development and attachment of one to three of the four pulmonary veins that normally attach to the left atrium of the heart, resulting in partial drainage back into the systemic venous circulation via an anomalous connection to the right atrium, the superior or inferior vena cava, the innominate vein, the coronary sinus or the left subclavian artery; in PAPVC, at least one pulmonary vein remains attached to the left atrium http://purl.obolibrary.org/obo/MP_0010443 total anomalous pulmonary venous connection, intracardiac http://purl.obolibrary.org/obo/MP_0010441 total anomalous pulmonary venous connection the pulmonary veins connect directly to the right side of heart (eg, coronary sinus or directly to the right atrium) instead of the left atrium http://purl.obolibrary.org/obo/MP_0010444 total anomalous pulmonary venous connection, infracardiac http://purl.obolibrary.org/obo/MP_0010441 total anomalous pulmonary venous connection the common pulmonary vein travels down anterior to the esophagus through the diaphragm to connect to the portal venous system instead of the left atrium http://purl.obolibrary.org/obo/MP_0010445 total anomalous pulmonary venous connection, mixed http://purl.obolibrary.org/obo/MP_0010441 total anomalous pulmonary venous connection the right and left pulmonary veins drain to different sites other than the left atrium; for example, the left pulmonary veins into the left vertical vein to the left innominate, and/or the right pulmonary veins directly into the right atrium or coronary sinus http://purl.obolibrary.org/obo/MP_0010446 heart left ventricle hypoplasia http://purl.obolibrary.org/obo/MP_0010580 decreased heart left ventricle size underdevelopment or reduced size of the heart left ventricle, often due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0010447 heart left ventricle aneurysm http://purl.obolibrary.org/obo/MP_0010421 ventricular aneurysm thinning, stretching and bulging of a weakened heart left ventricular wall http://purl.obolibrary.org/obo/MP_0010448 heart left ventricle outflow tract stenosis http://purl.obolibrary.org/obo/MP_0010429 abnormal heart left ventricle outflow tract morphology abnormal constriction or narrowing of the portion of the left ventricle through which blood normally flows into the aorta http://purl.obolibrary.org/obo/MP_0010449 heart right ventricle outflow tract stenosis http://purl.obolibrary.org/obo/MP_0010428 abnormal heart right ventricle outflow tract morphology abnormal constriction or narrowing of part of the anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk http://purl.obolibrary.org/obo/MP_0010450 atrial septal aneurysm http://purl.obolibrary.org/obo/MP_0003279 aneurysm a saclike thinning, stretching and widening of the heart atrial septum resulting from weakening of the septum wall http://purl.obolibrary.org/obo/MP_0010451 kidney microaneurysm http://purl.obolibrary.org/obo/MP_0003279 aneurysm focal dilation of arteriocapillary junctions in the kidney http://purl.obolibrary.org/obo/MP_0010452 retina microaneurysm http://purl.obolibrary.org/obo/MP_0003279 aneurysm focal dilation of arteriocapillary junctions in the retina http://purl.obolibrary.org/obo/MP_0010453 abnormal coronary vein morphology http://purl.obolibrary.org/obo/MP_0010551 abnormal coronary vessel morphology any structural anomaly of any of the veins that return blood from the heart muscles to the right atrium through the coronary sinus http://purl.obolibrary.org/obo/MP_0010455 aortopulmonary window http://purl.obolibrary.org/obo/MP_0010651 aorticopulmonary septal defect a defect between the great vessels that results from failure of the conotruncal ridges to fuse resulting in an abnormal communication between the aorta and the pulmonary arteries http://purl.obolibrary.org/obo/MP_0010456 hemitruncus http://purl.obolibrary.org/obo/MP_0000484 abnormal pulmonary artery morphology congenital heart defect in which the origin of a pulmonary artery, usually the right, arises from the ascending aorta instead of the pulmonary trunk with the aortic and pulmonary valves remaining separate http://purl.obolibrary.org/obo/MP_0010457 pulmonary artery stenosis http://purl.obolibrary.org/obo/MP_0006135 artery stenosis constriction or narrowing of the pulmonary artery http://purl.obolibrary.org/obo/MP_0010458 pulmonary trunk hypoplasia http://purl.obolibrary.org/obo/MP_0000486 abnormal pulmonary trunk morphology underdevelopment or reduced size of the region of the pulmonary artery that arises from the right ventricle to the division of the right and left pulmonary artery, usually due to reduced cell number http://purl.obolibrary.org/obo/MP_0010459 supravalvar pulmonary trunk stenosis http://purl.obolibrary.org/obo/MP_0006135 artery stenosis diffuse constriction or narrowing of the pulmonary trunk distal to the pulmonary valve http://purl.obolibrary.org/obo/MP_0010460 pulmonary artery hypoplasia http://purl.obolibrary.org/obo/MP_0000484 abnormal pulmonary artery morphology underdevelopment or reduced size of the artery that arises from the right ventricle and conveys unaerated blood to the lungs, usually due to reduced cell number http://purl.obolibrary.org/obo/MP_0010461 discontinuous pulmonary artery http://purl.obolibrary.org/obo/MP_0000484 abnormal pulmonary artery morphology one or more pulmonary arteries is disconnected from the main pulmonary trunk and arises from a patent ductus arteriosus http://purl.obolibrary.org/obo/MP_0010462 pulmonary artery aneurysm http://purl.obolibrary.org/obo/MP_0003279 aneurysm a protruding sac formed by the dilation of the wall of a pulmonary artery resulting from a weakening of the vessel wall http://purl.obolibrary.org/obo/MP_0010463 aorta stenosis http://purl.obolibrary.org/obo/MP_0006135 artery stenosis diffuse constriction or narrowing of the aorta http://purl.obolibrary.org/obo/MP_0010464 abnormal aortic arch and aortic arch branch attachment http://purl.obolibrary.org/obo/MP_0004113 abnormal aortic arch morphology any anomaly of the connection site of the aortic branches to the aortic arch, including the attachment sites for the left common carotid artery, the left subclavian artery, and the brachiocephalic trunk which further splits to form the right subclavian artery and the right common carotid artery http://purl.obolibrary.org/obo/MP_0010467 pulmonary artery sling http://purl.obolibrary.org/obo/MP_0010466 vascular ring anomalous origin of the left pulmonary artery from the posterior aspect of the right pulmonary artery, with the anomalous left pulmonary artery coursing over the right mainstem bronchus and then from right to left, posterior to the trachea or carina and anterior to the esophagus, to reach the hilum of the left lung, which compresses the lower trachea and right mainstem bronchus http://purl.obolibrary.org/obo/MP_0010469 ascending aorta hypoplasia http://purl.obolibrary.org/obo/MP_0009867 abnormal ascending aorta morphology underdevelopment or reduced size of the portion of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch and from which the coronary arteries arise, usually due to reduced cell number http://purl.obolibrary.org/obo/MP_0010470 ascending aorta dilation http://purl.obolibrary.org/obo/MP_0009867 abnormal ascending aorta morphology the luminal space of the ascending aorta is increased in volume or area, usually with an increase of contained fluid http://purl.obolibrary.org/obo/MP_0010471 supravalvar aortic stenosis http://purl.obolibrary.org/obo/MP_0011572 abnormal aorta bulb morphology a narrowing, diffuse constriction or obstruction of the ascending aorta located just distal to the aortic valve at the aortic root http://purl.obolibrary.org/obo/MP_0010472 abnormal ascending aorta and coronary artery attachment http://purl.obolibrary.org/obo/MP_0009867 abnormal ascending aorta morphology any anomaly of the connection site of any or all of the coronary arteries to the ascending aorta http://purl.obolibrary.org/obo/MP_0010473 descending aorta dilation http://purl.obolibrary.org/obo/MP_0009869 abnormal descending aorta morphology widening or enlargment of the lumen of the descending aorta http://purl.obolibrary.org/obo/MP_0010474 descending aorta hypoplasia http://purl.obolibrary.org/obo/MP_0009869 abnormal descending aorta morphology underdevelopment or reduced size of the descending aorta, usually due to reduced cell number http://purl.obolibrary.org/obo/MP_0010475 anomalous pulmonary origin of left coronary artery http://purl.obolibrary.org/obo/MP_0010472 abnormal ascending aorta and coronary artery attachment the left coronary artery arises from the pulmonary artery insead of the aorta http://purl.obolibrary.org/obo/MP_0010476 coronary fistula http://purl.obolibrary.org/obo/MP_0004111 abnormal coronary artery morphology an abnormal communication between the terminus of a coronary artery, bypassing the myocardial capillary bed and entering either a chamber of the heart (coronary-cameral fistula) or any segment of the systemic or pulmonary circulation (coronary arteriovenous fistula) http://purl.obolibrary.org/obo/MP_0010477 coronary artery aneurysm http://purl.obolibrary.org/obo/MP_0004111 abnormal coronary artery morphology a protruding sac formed by the dilation of the wall of a coronary artery resulting from a weakening of the vessel wall http://purl.obolibrary.org/obo/MP_0010478 intracranial aneurysm http://purl.obolibrary.org/obo/MP_0003279 aneurysm a protruding sac within the cranial space formed by the dilation of the wall of an artery or a vein resulting from a weakening of the vessel wall http://purl.obolibrary.org/obo/MP_0010479 brain aneurysm http://purl.obolibrary.org/obo/MP_0004950 abnormal brain vasculature morphology a protruding sac within the brain formed by the dilation of the wall of an artery or a vein resulting from a weakening of the vessel wall http://purl.obolibrary.org/obo/MP_0010480 pulmonary arteriovenous malformation http://purl.obolibrary.org/obo/MP_0006093 arteriovenous malformation abnormal communications between the pulmonary arteries and the pulmonary veins, or between a bronchial artery and the pulmonary vein http://purl.obolibrary.org/obo/MP_0010481 left ventricle to aorta tunnel http://purl.obolibrary.org/obo/MP_0009867 abnormal ascending aorta morphology an abnormal communication between the left ventricle and the ascending aorta in addition to the aortic valve http://purl.obolibrary.org/obo/MP_0010482 abnormal aortic sinus morphology http://purl.obolibrary.org/obo/MP_0011572 abnormal aorta bulb morphology any structural anomaly of the spaces betwen the superior aspect of each of the three cusps of the aortic valve and the dilated portion of the wall of the ascending aorta, immediately above each cusp; the three sinuses include the posterior (non-coronary sinus), and the right and left aortic sinuses (from which the left and right coronary arteries arise) http://purl.obolibrary.org/obo/MP_0010483 aortic sinus aneurysm http://purl.obolibrary.org/obo/MP_0010661 ascending aorta aneurysm a protruding sac formed by the dilation of the wall of the aortic sinus resulting from a weakening of the vessel wall http://purl.obolibrary.org/obo/MP_0010484 bicuspid aortic valve http://purl.obolibrary.org/obo/MP_0010595 abnormal aortic valve cusp morphology the presence of two cusps in the aortic valve instead of three http://purl.obolibrary.org/obo/CHEBI_22180 acetohydroxyacid synthase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_39208 antibiotic insecticide http://purl.obolibrary.org/obo/CHEBI_39215 antibiotic pesticide http://purl.obolibrary.org/obo/CHEBI_26413 pyrethroid insecticide http://purl.obolibrary.org/obo/CHEBI_39000 sodium channel modulator http://purl.obolibrary.org/obo/CHEBI_38577 triazole insecticide http://purl.obolibrary.org/obo/CHEBI_24852 insecticide http://purl.obolibrary.org/obo/CHEBI_39277 fumigant insecticide http://purl.obolibrary.org/obo/CHEBI_39276 fumigant http://purl.obolibrary.org/obo/CHEBI_39415 dinitrophenol insecticide http://purl.obolibrary.org/obo/CHEBI_24852 insecticide http://purl.obolibrary.org/obo/CHEBI_39217 antibiotic nematicide http://purl.obolibrary.org/obo/CHEBI_39215 antibiotic pesticide http://purl.obolibrary.org/obo/CHEBI_35219 plant growth retardant http://purl.obolibrary.org/obo/CHEBI_26155 plant growth regulator http://purl.obolibrary.org/obo/CHEBI_22581 antiauxins http://purl.obolibrary.org/obo/CHEBI_26155 plant growth regulator http://purl.obolibrary.org/obo/CHEBI_26157 plant growth stimulator http://purl.obolibrary.org/obo/CHEBI_26155 plant growth regulator http://purl.obolibrary.org/obo/CHEBI_62914 axin stabilizer http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role http://purl.obolibrary.org/obo/CHEBI_26083 phosphorus containing antibiotics http://purl.obolibrary.org/obo/CHEBI_22311 aliphatic antibiotics http://purl.obolibrary.org/obo/CHEBI_22309 alicyclic antibiotics http://purl.obolibrary.org/obo/CHEBI_22582 antibiotic http://purl.obolibrary.org/obo/CHEBI_22311 aliphatic antibiotics http://purl.obolibrary.org/obo/CHEBI_22582 antibiotic http://purl.obolibrary.org/obo/CHEBI_22476 amino acid derivative antibiotics http://purl.obolibrary.org/obo/CHEBI_22582 antibiotic http://purl.obolibrary.org/obo/CHEBI_39215 antibiotic pesticide http://purl.obolibrary.org/obo/CHEBI_22582 antibiotic http://purl.obolibrary.org/obo/CHEBI_39379 lepidopteran inhibitor of chitin biosynthesis http://purl.obolibrary.org/obo/CHEBI_23100 chitin synthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_33280 molecular messenger http://purl.obolibrary.org/obo/CHEBI_24432 biological role http://purl.obolibrary.org/obo/CHEBI_52208 biophysical role http://purl.obolibrary.org/obo/CHEBI_24432 biological role http://purl.obolibrary.org/obo/CHEBI_23100 chitin synthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_24851 insect growth regulator http://purl.obolibrary.org/obo/CHEBI_23891 ecdysone antagonists http://purl.obolibrary.org/obo/CHEBI_24851 insect growth regulator http://purl.obolibrary.org/obo/CHEBI_24941 juvenile hormone antagonists http://purl.obolibrary.org/obo/CHEBI_24851 insect growth regulator http://purl.obolibrary.org/obo/CHEBI_24942 juvenile hormone mimic http://purl.obolibrary.org/obo/CHEBI_24851 insect growth regulator http://purl.obolibrary.org/obo/CHEBI_38456 ecdysone agonist http://purl.obolibrary.org/obo/CHEBI_24851 insect growth regulator http://purl.obolibrary.org/obo/CHEBI_22986 calcium ionophore http://purl.obolibrary.org/obo/CHEBI_24869 ionophore http://purl.obolibrary.org/obo/CHEBI_24874 iron ionophore http://purl.obolibrary.org/obo/CHEBI_24869 ionophore http://purl.obolibrary.org/obo/CHEBI_26220 precocenes http://purl.obolibrary.org/obo/CHEBI_24941 juvenile hormone antagonists http://purl.obolibrary.org/obo/CHEBI_39116 pyrethroid ester insecticide http://purl.obolibrary.org/obo/CHEBI_26413 pyrethroid insecticide http://purl.obolibrary.org/obo/CHEBI_39351 pyrethroid ether insecticide http://purl.obolibrary.org/obo/CHEBI_26413 pyrethroid insecticide http://purl.obolibrary.org/obo/CHEBI_38497 respiratory-chain inhibitor http://purl.obolibrary.org/obo/CHEBI_38496 electron-transport chain inhibitor http://purl.obolibrary.org/obo/CHEBI_38501 cytochrome-c oxidase inhibitor http://purl.obolibrary.org/obo/CHEBI_38497 respiratory-chain inhibitor http://purl.obolibrary.org/obo/CHEBI_38502 cytochrome-bc1 complex inhibitor http://purl.obolibrary.org/obo/CHEBI_38497 respiratory-chain inhibitor http://purl.obolibrary.org/obo/CHEBI_39000 sodium channel modulator http://purl.obolibrary.org/obo/CHEBI_38632 membrane transport modulator http://purl.obolibrary.org/obo/CHEBI_50510 potassium channel modulator http://purl.obolibrary.org/obo/CHEBI_38632 membrane transport modulator http://purl.obolibrary.org/obo/CHEBI_39316 mite growth regulator http://purl.obolibrary.org/obo/CHEBI_22153 acaricide http://purl.obolibrary.org/obo/CHEBI_37335 MRI contrast agent http://purl.obolibrary.org/obo/CHEBI_37334 diagnostic imaging agent http://purl.obolibrary.org/obo/CHEBI_37336 radioactive imaging agent http://purl.obolibrary.org/obo/CHEBI_37334 diagnostic imaging agent http://purl.obolibrary.org/obo/CHEBI_39216 antibiotic acaricide http://purl.obolibrary.org/obo/CHEBI_22153 acaricide http://purl.obolibrary.org/obo/CHEBI_50410 colour indicator http://purl.obolibrary.org/obo/CHEBI_50408 visual indicator http://purl.obolibrary.org/obo/MP_0009944 abnormal olfactory lobe morphology http://purl.obolibrary.org/obo/MP_0000787 abnormal telencephalon morphology http://purl.obolibrary.org/obo/MP_0008284 abnormal hippocampus pyramidal cell layer http://purl.obolibrary.org/obo/MP_0000813 abnormal hippocampus layer morphology http://purl.obolibrary.org/obo/MP_0008285 abnormal hippocampus granule cell layer http://purl.obolibrary.org/obo/MP_0000813 abnormal hippocampus layer morphology http://purl.obolibrary.org/obo/MP_0008286 abnormal hippocampus molecular cell layer http://purl.obolibrary.org/obo/MP_0000813 abnormal hippocampus layer morphology http://purl.obolibrary.org/obo/MP_0008267 abnormal hippocampus CA3 region morphology http://purl.obolibrary.org/obo/MP_0008262 abnormal hippocampus region morphology http://purl.obolibrary.org/obo/MP_0008927 abnormal parafascicular nucleus morphology http://purl.obolibrary.org/obo/MP_0000832 abnormal thalamus morphology http://purl.obolibrary.org/obo/MP_0008931 abnormal paraventricular thalamic nucleus morphology http://purl.obolibrary.org/obo/MP_0000832 abnormal thalamus morphology http://purl.obolibrary.org/obo/MP_0009978 abnormal cerebellum white matter morphology http://purl.obolibrary.org/obo/MP_0008026 abnormal brain white matter morphology http://purl.obolibrary.org/obo/MP_0009988 abnormal cerebellum vermis lobule I morphology http://purl.obolibrary.org/obo/MP_0009957 abnormal cerebellum vermis lobule morphology http://purl.obolibrary.org/obo/MP_0009989 abnormal cerebellum vermis lobule II morphology http://purl.obolibrary.org/obo/MP_0009957 abnormal cerebellum vermis lobule morphology http://purl.obolibrary.org/obo/MP_0009990 abnormal cerebellum vermis lobule III morphology http://purl.obolibrary.org/obo/MP_0009957 abnormal cerebellum vermis lobule morphology http://purl.obolibrary.org/obo/MP_0009991 abnormal cerebellum vermis lobule IV morphology http://purl.obolibrary.org/obo/MP_0009957 abnormal cerebellum vermis lobule morphology http://purl.obolibrary.org/obo/MP_0009993 abnormal cerebellum vermis lobule V morphology http://purl.obolibrary.org/obo/MP_0009957 abnormal cerebellum vermis lobule morphology http://purl.obolibrary.org/obo/MP_0009992 abnormal cerebellum vermis lobule IX morphology http://purl.obolibrary.org/obo/MP_0009957 abnormal cerebellum vermis lobule morphology http://purl.obolibrary.org/obo/MP_0009996 abnormal cerebellum vermis lobule VIII morphology http://purl.obolibrary.org/obo/MP_0009957 abnormal cerebellum vermis lobule morphology http://purl.obolibrary.org/obo/MP_0009994 abnormal cerebellum vermis lobule VI morphology http://purl.obolibrary.org/obo/MP_0009957 abnormal cerebellum vermis lobule morphology http://purl.obolibrary.org/obo/MP_0009995 abnormal cerebellum vermis lobule VII morphology http://purl.obolibrary.org/obo/MP_0009957 abnormal cerebellum vermis lobule morphology http://purl.obolibrary.org/obo/MP_0010336 increased acute lymphoblastic leukemia incidence http://purl.obolibrary.org/obo/MP_0002026 increased leukemia incidence http://purl.obolibrary.org/obo/MP_0010337 increased chronic lymphocytic leukemia incidence http://purl.obolibrary.org/obo/MP_0002026 increased leukemia incidence http://purl.obolibrary.org/obo/MP_0004050 abnormal renal sympathetic nerve activity http://purl.obolibrary.org/obo/MP_0002136 abnormal kidney physiology http://purl.obolibrary.org/obo/MP_0004051 increased renal sympathetic nerve activity http://purl.obolibrary.org/obo/MP_0004050 abnormal renal sympathetic nerve activity http://purl.obolibrary.org/obo/MP_0004052 decreased renal sympathetic nerve activity http://purl.obolibrary.org/obo/MP_0004050 abnormal renal sympathetic nerve activity http://purl.obolibrary.org/obo/MP_0009627 abnormal submandibular lymph node morphology http://purl.obolibrary.org/obo/MP_0008463 abnormal peripheral lymph node morphology http://purl.obolibrary.org/obo/MP_0009572 abnormal right lung cranial lobe morphology http://purl.obolibrary.org/obo/MP_0010975 abnormal lung lobe morphology http://purl.obolibrary.org/obo/MP_0009573 abnormal right lung middle lobe morphology http://purl.obolibrary.org/obo/MP_0010975 abnormal lung lobe morphology http://purl.obolibrary.org/obo/MP_0009574 abnormal right lung caudal lobe morphology http://purl.obolibrary.org/obo/MP_0010975 abnormal lung lobe morphology http://purl.obolibrary.org/obo/MP_0008264 absent hippocampus CA1 region http://purl.obolibrary.org/obo/MP_0008263 abnormal hippocampus CA1 region morphology http://purl.obolibrary.org/obo/MP_0008266 absent hippocampus CA2 region http://purl.obolibrary.org/obo/MP_0008265 abnormal hippocampus CA2 region morphology http://purl.obolibrary.org/obo/MP_0008268 absent hippocampus CA3 region http://purl.obolibrary.org/obo/MP_0008267 abnormal hippocampus CA3 region morphology http://purl.obolibrary.org/obo/MP_0008270 absent hippocampus CA4 region http://purl.obolibrary.org/obo/MP_0008269 abnormal hippocampus CA4 region morphology http://purl.obolibrary.org/obo/MP_0009948 abnormal olfactory bulb glomerular layer morphology http://purl.obolibrary.org/obo/MP_0009946 abnormal olfactory bulb layer morphology http://purl.obolibrary.org/obo/MP_0009949 abnormal olfactory bulb granule cell layer morphology http://purl.obolibrary.org/obo/MP_0009946 abnormal olfactory bulb layer morphology http://purl.obolibrary.org/obo/MP_0009950 abnormal olfactory bulb internal plexiform layer morphology http://purl.obolibrary.org/obo/MP_0009946 abnormal olfactory bulb layer morphology http://purl.obolibrary.org/obo/MP_0009951 abnormal olfactory bulb mitral cell layer morphology http://purl.obolibrary.org/obo/MP_0009946 abnormal olfactory bulb layer morphology http://purl.obolibrary.org/obo/MP_0009997 abnormal cerebellum vermis lobule X morphology http://purl.obolibrary.org/obo/MP_0009961 abnormal flocculonodular lobe morphology http://purl.obolibrary.org/obo/MP_0010007 abnormal paraflocculus morphology http://purl.obolibrary.org/obo/MP_0009959 abnormal cerebellar hemisphere morphology http://purl.obolibrary.org/obo/MP_0010000 abnormal copula pyramidis morphology http://purl.obolibrary.org/obo/MP_0009963 abnormal cerebellum hemisphere lobule morphology http://purl.obolibrary.org/obo/MP_0010001 abnormal ansiform lobule morphology http://purl.obolibrary.org/obo/MP_0009963 abnormal cerebellum hemisphere lobule morphology http://purl.obolibrary.org/obo/MP_0010004 abnormal paramedian lobule morphology http://purl.obolibrary.org/obo/MP_0009963 abnormal cerebellum hemisphere lobule morphology http://purl.obolibrary.org/obo/MP_0010005 abnormal lobule simplex morphology http://purl.obolibrary.org/obo/MP_0009963 abnormal cerebellum hemisphere lobule morphology http://purl.obolibrary.org/obo/MP_0009998 abnormal cerebellum vermis lobule VIIa morphology http://purl.obolibrary.org/obo/MP_0009995 abnormal cerebellum vermis lobule VII morphology http://purl.obolibrary.org/obo/MP_0009999 abnormal cerebellum vermis lobule VIIb morphology http://purl.obolibrary.org/obo/MP_0009995 abnormal cerebellum vermis lobule VII morphology http://purl.obolibrary.org/obo/MP_0010002 abnormal ansiform lobule crus I morphology http://purl.obolibrary.org/obo/MP_0010001 abnormal ansiform lobule morphology http://purl.obolibrary.org/obo/MP_0010003 abnormal ansiform lobule crus II morphology http://purl.obolibrary.org/obo/MP_0010001 abnormal ansiform lobule morphology http://purl.obolibrary.org/obo/CHEBI_39301 sulfite ester acaricide http://purl.obolibrary.org/obo/CHEBI_22153 acaricide http://purl.obolibrary.org/obo/CHEBI_39318 tetrazine acaricide http://purl.obolibrary.org/obo/CHEBI_22153 acaricide http://purl.obolibrary.org/obo/CHEBI_50780 appetite regulator http://purl.obolibrary.org/obo/CHEBI_23888 drug http://purl.obolibrary.org/obo/CHEBI_51061 hormone receptor modulator http://purl.obolibrary.org/obo/CHEBI_23888 drug http://purl.obolibrary.org/obo/CHEBI_38234 DNA polymerase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_62872 retinoic acid synthase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_20569 5-enolpyruvylshikimate-3-phosphate synthase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_24319 glutamine synthetase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_38496 electron-transport chain inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_50643 farnesyl pyrophosphate synthetase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_37153 protein serine/threonine phosphatase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_50628 alpha-glucoside hydrolase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_62887 tankyrase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_63674 4-aminobutyrate transaminase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_26671 sideramine http://purl.obolibrary.org/obo/CHEBI_26672 siderophore http://purl.obolibrary.org/obo/CHEBI_33937 macronutrient http://purl.obolibrary.org/obo/CHEBI_33284 nutrient http://purl.obolibrary.org/obo/CHEBI_52215 photochemical role http://purl.obolibrary.org/obo/CHEBI_51086 chemical role http://purl.obolibrary.org/obo/CHEBI_24028 iron(3+) chelator http://purl.obolibrary.org/obo/CHEBI_38157 iron chelator http://purl.obolibrary.org/obo/CHEBI_38162 iron(2+) chelator http://purl.obolibrary.org/obo/CHEBI_38157 iron chelator http://purl.obolibrary.org/obo/CHEBI_24430 group transfer coenzymes http://purl.obolibrary.org/obo/CHEBI_23354 coenzyme http://purl.obolibrary.org/obo/CHEBI_22368 alpha-1-microglobulin-Ig alpha complex chromophores http://purl.obolibrary.org/obo/CHEBI_23240 chromophore http://purl.obolibrary.org/obo/CHEBI_26089 photosystem-II inhibitor http://purl.obolibrary.org/obo/CHEBI_26087 photosynthetic electron-transport chain inhibitor http://purl.obolibrary.org/obo/CHEBI_23529 cytochrome-b6f complex inhibitor http://purl.obolibrary.org/obo/CHEBI_26087 photosynthetic electron-transport chain inhibitor http://purl.obolibrary.org/obo/CHEBI_26088 photosystem-I inhibitor http://purl.obolibrary.org/obo/CHEBI_26087 photosynthetic electron-transport chain inhibitor http://purl.obolibrary.org/obo/CHEBI_37930 phenothiazine antipsychotic drug http://purl.obolibrary.org/obo/CHEBI_65190 first generation antipsychotic http://purl.obolibrary.org/obo/MP_0001186 pigmentation phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype http://purl.obolibrary.org/obo/MP_0002006 tumorigenesis http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype http://purl.obolibrary.org/obo/MP_0002873 normal phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype http://purl.obolibrary.org/obo/MP_0005367 renal/urinary system phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype http://purl.obolibrary.org/obo/MP_0005369 muscle phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype http://purl.obolibrary.org/obo/MP_0005370 liver/biliary system phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype http://purl.obolibrary.org/obo/MP_0005371 limbs/digits/tail phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype http://purl.obolibrary.org/obo/MP_0005376 homeostasis/metabolism phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype http://purl.obolibrary.org/obo/MP_0005377 hearing/vestibular/ear phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype http://purl.obolibrary.org/obo/MP_0005378 growth/size/body phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype http://purl.obolibrary.org/obo/MP_0005379 endocrine/exocrine gland phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype http://purl.obolibrary.org/obo/MP_0005380 embryogenesis phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype http://purl.obolibrary.org/obo/MP_0005381 digestive/alimentary phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype http://purl.obolibrary.org/obo/MP_0005382 craniofacial phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype http://purl.obolibrary.org/obo/MP_0005384 cellular phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype http://purl.obolibrary.org/obo/MP_0005387 immune system phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype http://purl.obolibrary.org/obo/MP_0005388 respiratory system phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype http://purl.obolibrary.org/obo/MP_0005389 reproductive system phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype http://purl.obolibrary.org/obo/MP_0005390 skeleton phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype http://purl.obolibrary.org/obo/MP_0005391 vision/eye phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype http://purl.obolibrary.org/obo/MP_0005394 taste/olfaction phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype http://purl.obolibrary.org/obo/MP_0005397 hematopoietic system phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype http://purl.obolibrary.org/obo/MP_0005395 other phenotype http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype http://purl.obolibrary.org/obo/MP_0010485 aortic arch hypoplasia http://purl.obolibrary.org/obo/MP_0004113 abnormal aortic arch morphology underdevelopment or reduced size of the aortic arch, usually due to reduced cell number http://purl.obolibrary.org/obo/MP_0010486 absent right subclavian artery http://purl.obolibrary.org/obo/MP_0010487 abnormal right subclavian artery morphology absence of one of the two subclavian arteries; the right subclavian artery normally extends from the brachiocephalic artery to the right side of the body http://purl.obolibrary.org/obo/MP_0010487 abnormal right subclavian artery morphology http://purl.obolibrary.org/obo/MP_0003395 abnormal subclavian artery morphology any structural anomaly of the artery that normally extends from the brachiocephalic artery to the right side of the body http://purl.obolibrary.org/obo/MP_0010488 abnormal left subclavian artery morphology http://purl.obolibrary.org/obo/MP_0003395 abnormal subclavian artery morphology any structural anomaly of the artery that extends from the aortic arch to the left side of the body http://purl.obolibrary.org/obo/MP_0010490 abnormal inferior vena cava valve morphology http://purl.obolibrary.org/obo/MP_0003922 abnormal heart right atrium morphology any structural anomaly of the semicircular fold of endocardium located on the right atrium at the point of attachment of the inferior vena cava http://purl.obolibrary.org/obo/MP_0010491 abnormal coronary sinus valve morphology http://purl.obolibrary.org/obo/MP_0003922 abnormal heart right atrium morphology any structural anomaly of the semicircular fold of the right atrial endocardium located at the coronary sinus attachment to the right atrium that serves to prevent the reflux of blood back to the coronary arteries during atrial contraction http://purl.obolibrary.org/obo/MP_0010492 abnormal atrium endocardium morphology http://purl.obolibrary.org/obo/MP_0003974 abnormal endocardium morphology any structural anomaly of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the atria http://purl.obolibrary.org/obo/MP_0010493 abnormal atrium myocardium morphology http://purl.obolibrary.org/obo/MP_0005329 abnormal myocardium layer morphology any structural anomaly of the atrial part of middle layer of the heart, comprised of involuntary muscle http://purl.obolibrary.org/obo/MP_0010494 abnormal ventricle endocardium morphology http://purl.obolibrary.org/obo/MP_0005294 abnormal heart ventricle morphology any structural anomaly of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the ventricles http://purl.obolibrary.org/obo/MP_0010495 abnormal crista terminalis morphology http://purl.obolibrary.org/obo/MP_0003922 abnormal heart right atrium morphology any structural anomaly of the vertical crest of the interior wall of the right atrium that lies to the right of the sinus of the vena cava and separates this from the remainder of the right atrium http://purl.obolibrary.org/obo/MP_0010496 abnormal pectinate muscle morphology http://purl.obolibrary.org/obo/MP_0010493 abnormal atrium myocardium morphology any structural anomaly of the prominent ridges of atrial myocardium located on the inner surface of most of the right atrium and both the right and left auricular regions http://purl.obolibrary.org/obo/MP_0010497 abnormal vena cava sinus morphology http://purl.obolibrary.org/obo/MP_0003922 abnormal heart right atrium morphology any structural anomaly of the portion of the cavity of the right atrium of the heart that receives the blood from the vena cavae and is separated from the rest of the atrium by the crista terminalis http://purl.obolibrary.org/obo/MP_0010498 abnormal interventricular septum muscular part morphology http://purl.obolibrary.org/obo/MP_0000281 abnormal interventricular septum morphology any structural anomaly of the muscular portion of the wall between the two lower chambers of the heart http://purl.obolibrary.org/obo/MP_0010500 myocardium hypoplasia http://purl.obolibrary.org/obo/MP_0005329 abnormal myocardium layer morphology underdevelopment or reduced size, usually due to a reduced number of cells, of the heart myocardium http://purl.obolibrary.org/obo/MP_0010501 atrium myocardium hypoplasia http://purl.obolibrary.org/obo/MP_0010500 myocardium hypoplasia underdevelopment or reduced size, usually due to a reduced number of cells, of the atrial part of the heart myocardium http://purl.obolibrary.org/obo/MP_0010504 abnormal RR interval http://purl.obolibrary.org/obo/MP_0010508 abnormal heart electrocardiography waveform feature anomaly in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate http://purl.obolibrary.org/obo/MP_0010505 abnormal T wave http://purl.obolibrary.org/obo/MP_0010508 abnormal heart electrocardiography waveform feature any anomaly in the T wave which is normally caused by the repolarization (or recovery) of the ventricles http://purl.obolibrary.org/obo/MP_0010506 prolonged RR interval http://purl.obolibrary.org/obo/MP_0010504 abnormal RR interval increase in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate http://purl.obolibrary.org/obo/MP_0010507 shortened RR interval http://purl.obolibrary.org/obo/MP_0010504 abnormal RR interval reduction in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate http://purl.obolibrary.org/obo/MP_0010509 decreased P wave amplitude http://purl.obolibrary.org/obo/MP_0004070 abnormal P wave reduction in the size (height or maximum displacement) of the P wave http://purl.obolibrary.org/obo/MP_0010510 absent P wave http://purl.obolibrary.org/obo/MP_0004070 abnormal P wave absence of the P wave which represents atrial depolarization and corresponds to electrical impulses rather than mechanical atria contractions http://purl.obolibrary.org/obo/MP_0010511 shortened PR interval http://purl.obolibrary.org/obo/MP_0003901 abnormal PR interval decrease in the length of time between the beginning of atrial depolarization and the beginning of ventricular depolarization, measured by the interval from the beginning of the P wave to the beginning of the QRS complex http://purl.obolibrary.org/obo/MP_0010512 absent PR interval http://purl.obolibrary.org/obo/MP_0003901 abnormal PR interval absence of the ECG segment representing the length of time between the beginning of atrial depolarization and the beginning of ventricular depolarization, measured by the interval from the beginning of the P wave to the beginning of the QRS complex http://purl.obolibrary.org/obo/MP_0010513 abnormal ventricular activation time http://purl.obolibrary.org/obo/MP_0003898 abnormal QRS complex any anomaly in the length of time from the beginning of the Q wave to the peak of the R wave http://purl.obolibrary.org/obo/MP_0010514 fragmented QRS complex http://purl.obolibrary.org/obo/MP_0003898 abnormal QRS complex changes in QRS waveform pattern including different RSR' patterns, additional R waves, notched or absent Q or S wave, or more than one R wave http://purl.obolibrary.org/obo/MP_0010515 abnormal Q wave http://purl.obolibrary.org/obo/MP_0003898 abnormal QRS complex any anomaly in the downward deflection in the ECG occurring after the PR interval that represents depolarization of the interventricular septum http://purl.obolibrary.org/obo/MP_0010516 absent Q wave http://purl.obolibrary.org/obo/MP_0010515 abnormal Q wave absence of the downward deflection in the ECG occurring after the PR interval that represents depolarization of the interventricular septum http://purl.obolibrary.org/obo/MP_0010517 abnormal Bachmann's bundle morphology http://purl.obolibrary.org/obo/MP_0004123 abnormal impulse conducting system morphology any structural anomaly of the impulse conduction tract that originates in the sinoatrial node and transmits signal to the left atrium http://purl.obolibrary.org/obo/MP_0010521 absent pulmonary artery http://purl.obolibrary.org/obo/MP_0000484 abnormal pulmonary artery morphology absence of the artery that arises from the right ventricle and conveys unaerated blood to the lungs http://purl.obolibrary.org/obo/MP_0010522 calcified aorta http://purl.obolibrary.org/obo/MP_0006133 calcified artery pathologic deposition of calcium salts in the aorta http://purl.obolibrary.org/obo/MP_0010523 calcified thoracic aorta http://purl.obolibrary.org/obo/MP_0010522 calcified aorta pathologic deposition of calcium salts in the part of the aorta that extends from the origin at the heart to the diaphragm http://purl.obolibrary.org/obo/MP_0010524 calcified aortic arch http://purl.obolibrary.org/obo/MP_0010523 calcified thoracic aorta pathologic deposition of calcium salts in the convex portion of the aorta between the ascending and descending parts of the aorta http://purl.obolibrary.org/obo/MP_0010525 abdominal aorta coarctation http://purl.obolibrary.org/obo/MP_0009870 abnormal abdominal aorta morphology a congenital focal constriction of the abdominal aorta http://purl.obolibrary.org/obo/MP_0010526 aortic arch coarctation http://purl.obolibrary.org/obo/MP_0004113 abnormal aortic arch morphology a congenital focal constriction of the aortic arch http://purl.obolibrary.org/obo/MP_0010527 bicuspid pulmonary valve http://purl.obolibrary.org/obo/MP_0010602 abnormal pulmonary valve cusp morphology the presence of two cusps or leaflets in the pulmonary valve instead of three http://purl.obolibrary.org/obo/MP_0010528 pulmonary vein hypoplasia http://purl.obolibrary.org/obo/MP_0002726 abnormal pulmonary vein morphology underdevelopment or reduced size of the veins that return oxygenated blood from the lungs to the left atrium of the heart, usually due to reduced cell number http://purl.obolibrary.org/obo/MP_0010529 hepatic arteriovenous malformation http://purl.obolibrary.org/obo/MP_0009820 abnormal liver vasculature morphology congenital vascular anomaly in the liver characterized by direct communication between an artery and a vein without passing through the capillary bed http://purl.obolibrary.org/obo/MP_0010530 cerebral arteriovenous malformation http://purl.obolibrary.org/obo/MP_0006093 arteriovenous malformation congenital vascular anomaly in the cerebrum characterized by direct communication between an artery and a vein without passing through the capillary bed http://purl.obolibrary.org/obo/MP_0010531 gastrointestinal arteriovenous malformation http://purl.obolibrary.org/obo/MP_0006093 arteriovenous malformation congenital vascular anomaly in the gastrointestinal system characterized by direct communication between an artery and a vein without passing through the capillary bed http://purl.obolibrary.org/obo/MP_0010532 absent atrioventricular node http://purl.obolibrary.org/obo/MP_0004114 abnormal atrioventricular node morphology absence of the small nodular mass of specialized muscle fibers located in the interatrial septum near the opening of the coronary sinus http://purl.obolibrary.org/obo/MP_0010533 atrioventricular node hypoplasia http://purl.obolibrary.org/obo/MP_0004114 abnormal atrioventricular node morphology underdevelopment or reduced size, usually due to a reduced number of cells, of the small nodular mass of specialized muscle fibers located in the interatrial septum near the opening of the coronary sinus http://purl.obolibrary.org/obo/MP_0010534 calcified myocardium http://purl.obolibrary.org/obo/MP_0005329 abnormal myocardium layer morphology pathologic deposition of calcium salts in the myocardium http://purl.obolibrary.org/obo/MP_0010535 myocardial steatosis http://purl.obolibrary.org/obo/MP_0005329 abnormal myocardium layer morphology an accumulation of fat deposits in the myocardium http://purl.obolibrary.org/obo/MP_0010536 Ebstein's malformation of tricuspid valve http://purl.obolibrary.org/obo/MP_0002624 abnormal tricuspid valve morphology a congenital downward displacement of the septal and posterior leaflets of the tricuspid valve into the inlet portion of the right ventricle http://purl.obolibrary.org/obo/MP_0010537 tumor regression http://purl.obolibrary.org/obo/MP_0010639 altered tumor pathology a decrease in tumor size from a formerly larger state and/or a decrease in the extent of tumors in the body http://purl.obolibrary.org/obo/MP_0010538 increased level of surface class II molecules http://purl.obolibrary.org/obo/MP_0005042 abnormal level of surface class II molecules increase in the concentration of major histocompatibility complex class II molecules expressed at the cell surface http://purl.obolibrary.org/obo/MP_0010539 decreased level of surface class II molecules http://purl.obolibrary.org/obo/MP_0005042 abnormal level of surface class II molecules reduction in the concentration of major histocompatibility complex class II molecules expressed at the cell surface http://purl.obolibrary.org/obo/MP_0010540 long stride length http://purl.obolibrary.org/obo/MP_0001406 abnormal gait increased average distance between steps http://purl.obolibrary.org/obo/MP_0010541 aorta hypoplasia http://purl.obolibrary.org/obo/MP_0000272 abnormal aorta morphology underdevelopment or reduced size of the main trunk of the systemic arterial system that originates from the base of the left ventricle of the heart and extends to the abdomen at the point where it branches into the common iliac arteries, usually due to reduced cell number http://purl.obolibrary.org/obo/MP_0010542 right ventricular myocardium hypoplasia http://purl.obolibrary.org/obo/MP_0010502 ventricle myocardium hypoplasia underdevelopment or reduced size, usually due to a reduced number of cells, of the heart right ventricular part of the heart myocardium http://purl.obolibrary.org/obo/MP_0010543 aorta tubular hypoplasia http://purl.obolibrary.org/obo/MP_0010541 aorta hypoplasia a diffuse narrowing of the lumen of the aorta http://purl.obolibrary.org/obo/MP_0010546 abnormal subendocardium layer morphology http://purl.obolibrary.org/obo/MP_0010545 abnormal heart layer morphology any structural anomaly of the layer of loose fibrous tissue located between the endocardium and myocardium which contains the nerves and the impulse-conducting system (Purkinje fibers) of the heart http://purl.obolibrary.org/obo/MP_0010547 abnormal mesocardium morphology http://purl.obolibrary.org/obo/MP_0000267 abnormal heart development any structural anomaly of the layer of splanchnic mesoderm supporting the embryonic heart in the pericardial cavity; mesocardium normally regresses before birth http://purl.obolibrary.org/obo/MP_0010548 abnormal dorsal mesocardium morphology http://purl.obolibrary.org/obo/MP_0010547 abnormal mesocardium morphology any structural anomaly of the part of the mesocardium that lies dorsal to the embryonic heart; the dorsal mesocardium gives rise to the transverse sinus of the pericardium in the adult http://purl.obolibrary.org/obo/MP_0010549 absent dorsal mesocardium http://purl.obolibrary.org/obo/MP_0010548 abnormal dorsal mesocardium morphology absence of the part of the mesocardium that lies dorsal to the embryonic heart; the dorsal mesocardium gives rise to the transverse sinus of the pericardium in the adult http://purl.obolibrary.org/obo/MP_0010552 abnormal HV interval http://purl.obolibrary.org/obo/MP_0010508 abnormal heart electrocardiography waveform feature any anomaly in the time from the initial deflection of the His bundle (H) potential and the onset of ventricular activity http://purl.obolibrary.org/obo/MP_0010553 prolonged HV interval http://purl.obolibrary.org/obo/MP_0010552 abnormal HV interval increase in the length of time from the initial deflection of the His bundle (H) potential and the onset of ventricular activity http://purl.obolibrary.org/obo/MP_0010554 shortened HV interval http://purl.obolibrary.org/obo/MP_0010552 abnormal HV interval decrease in the length of time from the initial deflection of the His bundle (H) potential and the onset of ventricular activity http://purl.obolibrary.org/obo/MP_0010555 absent epicardium http://purl.obolibrary.org/obo/MP_0003057 abnormal epicardium morphology absence of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart http://purl.obolibrary.org/obo/MP_0010556 thin ventricle myocardium compact layer http://purl.obolibrary.org/obo/MP_0010502 ventricle myocardium hypoplasia reduced thickness of the ventricular portion of the outer, dense layer of the myocardium http://purl.obolibrary.org/obo/MP_0010557 dilated pulmonary artery http://purl.obolibrary.org/obo/MP_0000484 abnormal pulmonary artery morphology the luminal space of the pulmonary artery is increased in volume or area, usually with an increase of contained fluid http://purl.obolibrary.org/obo/MP_0010558 sinus venosus hypoplasia http://purl.obolibrary.org/obo/MP_0003228 abnormal sinus venosus morphology underdevelopment or reduced size of the cavity at the caudal end of the embryonic cardiac tube in which the veins from the intra- and extraembryonic circulatory arcs unite, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0010559 heart block http://purl.obolibrary.org/obo/MP_0003137 abnormal impulse conducting system conduction a partial or complete obstruction of the propogation of electric impulses through the impulse conduction system of the heart http://purl.obolibrary.org/obo/MP_0010560 intraventricular block http://purl.obolibrary.org/obo/MP_0010559 heart block absent or delayed conduction within the ventricular conducting system or in the ventricular myocardium http://purl.obolibrary.org/obo/MP_0010561 absent coronary vessels http://purl.obolibrary.org/obo/MP_0010551 abnormal coronary vessel morphology absence of the arteries and veins that supply blood to the heart or return blood from the heart muscles to the circulation http://purl.obolibrary.org/obo/MP_0010562 absent sinus venosus http://purl.obolibrary.org/obo/MP_0003228 abnormal sinus venosus morphology absence of the cavity at the caudal end of the embryonic cardiac tube in which the veins from the intra- and extraembryonic circulatory arcs unite http://purl.obolibrary.org/obo/MP_0010565 absent fetal ductus arteriosus http://purl.obolibrary.org/obo/MP_0010564 abnormal fetal ductus arteriosus morphology absence of the fetal vessel that connects the left pulmonary artery with the descending aorta http://purl.obolibrary.org/obo/MP_0010566 abnormal left posterior bundle morphology http://purl.obolibrary.org/obo/MP_0004117 abnormal atrioventricular bundle morphology any structural anomaly of the left branch of the atrioventricular bundle that separates at the bundle of His, descends the septal wall of the left ventricle and connects to the terminal Purkinje fiber http://purl.obolibrary.org/obo/MP_0010567 abnormal right bundle morphology http://purl.obolibrary.org/obo/MP_0004117 abnormal atrioventricular bundle morphology any structural anomaly of the right branch of the atrioventricular bundle that separates just below the bundle of His, descends the septal wall of the right ventricle and connects to the terminal Purkinje fibers http://purl.obolibrary.org/obo/MP_0010568 abnormal bulbus cordis morphology http://purl.obolibrary.org/obo/MP_0000270 abnormal heart tube morphology any structural anomaly of a transient fetal dilation of the distal (or cranial) heart tube located where the arterial trunk joins the ventral roots of the aortic arches http://purl.obolibrary.org/obo/MP_0010569 papillary muscle hypertrophy http://purl.obolibrary.org/obo/MP_0004058 abnormal ventricle papillary muscle morphology increased bulk size of the group of myocardial bundles which terminate in the chordae tendineae that attach to the cusps of the atrioventricular valves http://purl.obolibrary.org/obo/MP_0010570 prolonged ST segment http://purl.obolibrary.org/obo/MP_0003897 abnormal ST segment increase in the length of time between the end of S-wave and the beginning of T-wave; reflects the amount of time the ventricles remain electrically depolarized http://purl.obolibrary.org/obo/MP_0010571 shortened ST segment http://purl.obolibrary.org/obo/MP_0003897 abnormal ST segment reduction in the length of time between the end of S-wave and the beginning of T-wave; reflects the amount of time the ventricles remain electrically depolarized http://purl.obolibrary.org/obo/MP_0010572 persistent right dorsal aorta http://purl.obolibrary.org/obo/MP_0004787 abnormal dorsal aorta morphology persistence of the right dorsal aorta after development; the right dorsal aorta normally regresses but when it persists, a double aortic arch develops; if the left dorsal aorta also regresses, a right aortic arch forms http://purl.obolibrary.org/obo/MP_0010573 left dorsal aorta regression http://purl.obolibrary.org/obo/MP_0004787 abnormal dorsal aorta morphology regression of the left dorsal aorta which normally develops into the aortic arch; together with a persistent right dorsal aorta, a right aortic arch forms http://purl.obolibrary.org/obo/MP_0010574 aorta dilation http://purl.obolibrary.org/obo/MP_0000272 abnormal aorta morphology the luminal space of the aorta is increased in volume or area, usually with an increase of contained fluid http://purl.obolibrary.org/obo/MP_0010575 aortic arch dilation http://purl.obolibrary.org/obo/MP_0004113 abnormal aortic arch morphology the luminal space of the aortic arch is increased in volume or area, usually with an increase of contained fluid http://purl.obolibrary.org/obo/MP_0010576 premature closure of the ductus arteriosus http://purl.obolibrary.org/obo/MP_0010564 abnormal fetal ductus arteriosus morphology premature regression of the ductus arteriosus that normally regresses into a fibrous cord, the ligamentum arteriousum after birth http://purl.obolibrary.org/obo/MP_0010578 abnormal heart left ventricle size http://purl.obolibrary.org/obo/MP_0003921 abnormal heart left ventricle morphology anomaly of the average size of the left ventricle compared to the average for a particular population http://purl.obolibrary.org/obo/MP_0010581 abnormal atrium myocardial trabeculae morphology http://purl.obolibrary.org/obo/MP_0010493 abnormal atrium myocardium morphology any structural anomaly of the supporting bundles of muscular fibers lining the walls of the atria http://purl.obolibrary.org/obo/MP_0010582 abnormal bulbus cordis septation http://purl.obolibrary.org/obo/MP_0010568 abnormal bulbus cordis morphology anomaly in the process in which the distal swelling of the primitive heart tube separates into an inferior end, which will form much of the right ventricle, and a superior end, which first form an outflow channel called the conotruncus; the conotruncus will in turn give rise to the more proximal conus cordis and the more distal truncus arteriosus http://purl.obolibrary.org/obo/MP_0010583 abnormal conotruncus morphology http://purl.obolibrary.org/obo/MP_0000270 abnormal heart tube morphology any structural anomaly of the distal portion of the bulbus cordis that will give rise to the conus cordis, which will give rise to the outflow regions of the ventricles, and the truncus arteriosus which will be divided into proximal ends of the ascending aorta and pulmonary trunk http://purl.obolibrary.org/obo/MP_0010584 abnormal conotruncus septation http://purl.obolibrary.org/obo/MP_0010583 abnormal conotruncus morphology anomaly in the process in which the conotruncus separates into the conus cordis, which will give rise to the outflow regions of the ventricles, and the truncus arteriosus which will be divided into proximal ends of the ascending aorta and pulmonary trunk http://purl.obolibrary.org/obo/MP_0010585 abnormal conotruncal ridge morphology http://purl.obolibrary.org/obo/MP_0010583 abnormal conotruncus morphology any structural anomaly of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum http://purl.obolibrary.org/obo/MP_0010586 absent conotruncal ridges http://purl.obolibrary.org/obo/MP_0010585 abnormal conotruncal ridge morphology absence of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum http://purl.obolibrary.org/obo/MP_0010587 conotruncal ridge hypoplasia http://purl.obolibrary.org/obo/MP_0010585 abnormal conotruncal ridge morphology underdevelopment or reduced size of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum http://purl.obolibrary.org/obo/MP_0010588 conotruncal ridge hyperplasia http://purl.obolibrary.org/obo/MP_0010585 abnormal conotruncal ridge morphology overdevelopment or increased size of the pair of spiral mesenchymal swellings in the primordial ventricular outflow tract, that eventually fuse to form the conotruncal septum, dividing the subvalvular outflow tract and contributing to the membranous interventricular septum http://purl.obolibrary.org/obo/MP_0010589 common truncal valve http://purl.obolibrary.org/obo/MP_0010454 abnormal truncus arteriosus septation a single outflow tract valve that opens into the truncus arteriosus that is frequently present in cases of truncus arteriosus septation defects http://purl.obolibrary.org/obo/MP_0010590 common truncal valve stenosis http://purl.obolibrary.org/obo/MP_0010589 common truncal valve abnormal constriction or narrowing of the single outflow tract valve that opens into the truncus arteriosus that is frequently present in cases of truncus arteriosus septation defects http://purl.obolibrary.org/obo/MP_0010591 enlarged aortic valve http://purl.obolibrary.org/obo/MP_0002747 abnormal aortic valve morphology an increase in the total area occupied by the aortic valve http://purl.obolibrary.org/obo/MP_0010592 abnormal atrioventricular septum morphology http://purl.obolibrary.org/obo/MP_0006113 abnormal heart septum morphology any structural anomaly of the wall of the heart that separates the right atrium and left ventricle; and is located just above the septal cusp of the tricuspid valve http://purl.obolibrary.org/obo/MP_0010593 thick aortic valve cusps http://purl.obolibrary.org/obo/MP_0011648 thick heart valve cusps an increase in the ratio of the aortic valve cusp thickness to the aortic wall thickness http://purl.obolibrary.org/obo/MP_0010594 thick aortic valve http://purl.obolibrary.org/obo/MP_0002747 abnormal aortic valve morphology an increase in the ratio of the aortic valve wall thickness to the aortic wall thickness http://purl.obolibrary.org/obo/MP_0010595 abnormal aortic valve cusp morphology http://purl.obolibrary.org/obo/MP_0002747 abnormal aortic valve morphology any structural anomaly of the three fibrous triangular components and associated flap of the aortic valve http://purl.obolibrary.org/obo/MP_0010596 unicuspid aortic valve http://purl.obolibrary.org/obo/MP_0010595 abnormal aortic valve cusp morphology the presence of one cusp and associated flap in the aortic valve instead of three http://purl.obolibrary.org/obo/MP_0010597 absent aortic valve cusps http://purl.obolibrary.org/obo/MP_0010595 abnormal aortic valve cusp morphology absence of the three fibrous triangular components and associated flaps of the aortic valve http://purl.obolibrary.org/obo/MP_0010598 abnormal aortic valve anulus morphology http://purl.obolibrary.org/obo/MP_0002747 abnormal aortic valve morphology any structural anomaly of the fibrous ring of the aortic valve that attaches the cusps of aortic valve to the wall of left ventricle, and which consists of portions of the fibrous scallops of the posterior, right anterior and left anterior cusps http://purl.obolibrary.org/obo/MP_0010600 enlarged pulmonary valve http://purl.obolibrary.org/obo/MP_0002748 abnormal pulmonary valve morphology an increase in the total area occupied by the pulmonary valve http://purl.obolibrary.org/obo/MP_0010601 thick pulmonary valve http://purl.obolibrary.org/obo/MP_0002748 abnormal pulmonary valve morphology an increase in the ratio of the pulmonary valve wall thickness to the pulmonary artery wall thickness http://purl.obolibrary.org/obo/MP_0010602 abnormal pulmonary valve cusp morphology http://purl.obolibrary.org/obo/MP_0002748 abnormal pulmonary valve morphology any structural anomaly of the three fibrous triangular components and associated flap of the pulmonary valve http://purl.obolibrary.org/obo/MP_0010603 unicuspid pulmonary valve http://purl.obolibrary.org/obo/MP_0010602 abnormal pulmonary valve cusp morphology the presence of one cusp and associated flap in the pulmonary valve instead of three http://purl.obolibrary.org/obo/MP_0010604 absent pulmonary valve cusps http://purl.obolibrary.org/obo/MP_0010602 abnormal pulmonary valve cusp morphology absence of the three fibrous triangular components and associated flaps of the pulmonary valve http://purl.obolibrary.org/obo/MP_0010605 thick pulmonary valve cusps http://purl.obolibrary.org/obo/MP_0011648 thick heart valve cusps an increase in the ratio of the pulmonary valve cusp thickness to the pulmonary artery wall thickness http://purl.obolibrary.org/obo/MP_0010606 abnormal pulmonary valve anulus morphology http://purl.obolibrary.org/obo/MP_0002748 abnormal pulmonary valve morphology any structural anomaly of the fibrous ring of the pulmonary valve that attaches the cusps of pulmonary valve to the wall of right ventricle, and which consists of portions of the fibrous scallops of the anterior, right posterior and left posterior cusps http://purl.obolibrary.org/obo/MP_0010607 common atrioventricular valve http://purl.obolibrary.org/obo/MP_0002745 abnormal atrioventricular valve morphology the presence of a single atrioventricular valve instead of both a mitral and tricuspid valve, most commonly due to incomplete or failure of fetal atrioventricular canal septation http://purl.obolibrary.org/obo/MP_0010608 abnormal chordae tendineae morphology http://purl.obolibrary.org/obo/MP_0002745 abnormal atrioventricular valve morphology any structural anomaly of the tendinous strands that connect the papillary muscles on the wall of the ventricles to the leaflets of the atrioventricular valves; the chordae tendineae serve to prevent the AV valves from prolapsing back into the atria http://purl.obolibrary.org/obo/MP_0010609 absent chordae tendineae http://purl.obolibrary.org/obo/MP_0010608 abnormal chordae tendineae morphology absence of the tendinous strands that connect the papillary muscles on the wall of the ventricles to the leaflets of the atrioventricular valves; the chordae tendineae serve to prevent the AV valves from prolapsing back into the atria http://purl.obolibrary.org/obo/MP_0010610 patent aortic valve http://purl.obolibrary.org/obo/MP_0002747 abnormal aortic valve morphology the aortic valve remains open during the cardiac cycle http://purl.obolibrary.org/obo/MP_0010611 patent pulmonary valve http://purl.obolibrary.org/obo/MP_0002748 abnormal pulmonary valve morphology the pulmonary valve remains open during the cardiac cycle http://purl.obolibrary.org/obo/MP_0010612 muscular subaortic stenosis http://purl.obolibrary.org/obo/MP_0010448 heart left ventricle outflow tract stenosis a narrowing or obstruction of the left ventricular outflow tract resulting from hypertrophy of the interventricular septum, which results in obstruction to blood flow http://purl.obolibrary.org/obo/MP_0010613 abnormal mitral valve anulus morphology http://purl.obolibrary.org/obo/MP_0000286 abnormal mitral valve morphology any structural anomaly of the fibrous ring of the mitral valve that attaches the cusps of mitral valve to the heart, and which consists of portions of the fibrous scallops of the anterior and posterior cusps http://purl.obolibrary.org/obo/MP_0010614 abnormal mitral valve cusp morphology http://purl.obolibrary.org/obo/MP_0000286 abnormal mitral valve morphology any structural anomaly of the two fibrous components and associated flaps of the mitral valve http://purl.obolibrary.org/obo/MP_0010615 unicuspid mitral valve http://purl.obolibrary.org/obo/MP_0010614 abnormal mitral valve cusp morphology the presence of one cusp and associated flap in the mitral valve instead of two http://purl.obolibrary.org/obo/MP_0010616 absent mitral valve cusps http://purl.obolibrary.org/obo/MP_0010614 abnormal mitral valve cusp morphology absence of the two fibrous components and associated flaps of the mitral valve http://purl.obolibrary.org/obo/MP_0010617 thick mitral valve cusps http://purl.obolibrary.org/obo/MP_0011648 thick heart valve cusps an increase in the ratio of the mitral valve cusp wall thickness to the atrioventricular septum thickness http://purl.obolibrary.org/obo/MP_0010618 enlarged mitral valve http://purl.obolibrary.org/obo/MP_0000286 abnormal mitral valve morphology an increase in the total area occupied by the mitral valve http://purl.obolibrary.org/obo/MP_0010619 patent mitral valve http://purl.obolibrary.org/obo/MP_0000286 abnormal mitral valve morphology the mitral valve remains open during the cardiac cycle http://purl.obolibrary.org/obo/MP_0010620 thick mitral valve http://purl.obolibrary.org/obo/MP_0000286 abnormal mitral valve morphology an increase in the ratio of the mitral valve wall thickness to the atrioventricular septum thickness http://purl.obolibrary.org/obo/MP_0010621 abnormal tricuspid valve anulus morphology http://purl.obolibrary.org/obo/MP_0002624 abnormal tricuspid valve morphology any structural anomaly of the fibrous ring of the tricuspid valve that attaches the cusps of tricuspid valve to the heart, and which consists of portions of the fibrous scallops of the anterior cusp (infundibular cusp), the posterior cusp (marginal cusp), and the septal cusp (medial cusp) http://purl.obolibrary.org/obo/MP_0010622 abnormal tricuspid valve cusp morphology http://purl.obolibrary.org/obo/MP_0002624 abnormal tricuspid valve morphology any structural anomaly of the three fibrous triangular components and associated flaps of the tricuspid valve http://purl.obolibrary.org/obo/MP_0010623 bicuspid tricuspid valve http://purl.obolibrary.org/obo/MP_0010622 abnormal tricuspid valve cusp morphology the presence of two cusps and associated flaps in the tricuspid valve instead of three http://purl.obolibrary.org/obo/MP_0010624 unicuspid tricuspid valve http://purl.obolibrary.org/obo/MP_0010622 abnormal tricuspid valve cusp morphology the presence of one cusp and associated flap in the tricuspid valve instead of three http://purl.obolibrary.org/obo/MP_0010625 absent tricuspid valve cusps http://purl.obolibrary.org/obo/MP_0010622 abnormal tricuspid valve cusp morphology absence of the three fibrous triangular components and associated flaps of the tricuspid valve http://purl.obolibrary.org/obo/MP_0010626 thick tricuspid valve cusps http://purl.obolibrary.org/obo/MP_0011648 thick heart valve cusps an increase in the ratio of the tricuspid valve cusp wall thickness to the atrioventricular septum thickness http://purl.obolibrary.org/obo/MP_0010627 enlarged tricuspid valve http://purl.obolibrary.org/obo/MP_0002624 abnormal tricuspid valve morphology an increase in the total area occupied by the tricuspid valve http://purl.obolibrary.org/obo/MP_0010628 patent tricuspid valve http://purl.obolibrary.org/obo/MP_0002624 abnormal tricuspid valve morphology the tricuspid valve remains open during the cardiac cycle http://purl.obolibrary.org/obo/MP_0010629 thick tricuspid valve http://purl.obolibrary.org/obo/MP_0002624 abnormal tricuspid valve morphology an increase in the ratio of the tricuspid valve wall thickness to the atrioventricular septum thickness http://purl.obolibrary.org/obo/MP_0010631 increased Q wave amplitude http://purl.obolibrary.org/obo/MP_0010515 abnormal Q wave increase in the size (height or maximum displacement) of the downward deflection in the ECG occurring after the PR interval that represents depolarization of the interventricular septum http://purl.obolibrary.org/obo/MP_0010632 cardiac muscle necrosis http://purl.obolibrary.org/obo/MP_0010630 abnormal cardiac muscle tissue morphology morphological changes resulting from pathological death of cardiomyocytes or a portion of the cardiac muscle tissue; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0010633 myocardial hypertrophy http://purl.obolibrary.org/obo/MP_0005329 abnormal myocardium layer morphology an increase in size of the myocardium, not due to increased cell number http://purl.obolibrary.org/obo/MP_0010634 increased QRS amplitude http://purl.obolibrary.org/obo/MP_0003898 abnormal QRS complex increased in the size (height or maximum displacement) of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction, suggesting ventricular excitation defects http://purl.obolibrary.org/obo/MP_0010635 aorta pulmonary collateral arteries http://purl.obolibrary.org/obo/MP_0004007 abnormal lung vasculature morphology small ectopic arteries or arterial branches that connect the aorta, aortic branches and/or subclavian artery regions directly to the lung parenchyma, usually seen in conjunction with pulmonary atresia, ventricular septal defect (VSD) and/or closed ductus arteriosus http://purl.obolibrary.org/obo/MP_0010636 bundle branch block http://purl.obolibrary.org/obo/MP_0010560 intraventricular block intraventricular block resulting from an interruption or partial or complete block of conduction in one of the two atrioventricular bundle branches; a prolonged QRS complex seen on an ECG indicates defects in bundle branch conduction; blocks in each branch result in a distinct QRS ECG waveform morphology http://purl.obolibrary.org/obo/MP_0010637 sinus bradycardia http://purl.obolibrary.org/obo/MP_0005333 decreased heart rate a type of decreased heart rhythm in which fewer than the normal number of impulses arise from the sinoatrial (SA) node http://purl.obolibrary.org/obo/MP_0010638 absent intercalated discs http://purl.obolibrary.org/obo/MP_0006267 abnormal intercalated disc morphology absence of the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes http://purl.obolibrary.org/obo/MP_0010640 ventricular myocardium compact layer hypoplasia http://purl.obolibrary.org/obo/MP_0010502 ventricle myocardium hypoplasia underdevelopment or reduced size, usually due to a reduced number of cells, of the ventricular portion of the outer, dense layer of the myocardium http://purl.obolibrary.org/obo/MP_0010641 descending aorta stenosis http://purl.obolibrary.org/obo/MP_0010463 aorta stenosis diffuse constriction or narrowing of the descending aorta http://purl.obolibrary.org/obo/MP_0010642 absent third pharyngeal arch http://purl.obolibrary.org/obo/MP_0006339 abnormal third pharyngeal arch morphology absence of the structure of the third are which contributes to the development of the hyoid bone, stylopharyngeus muscle, inferior parathyroid gland, and thymus http://purl.obolibrary.org/obo/MP_0010643 absent fourth pharyngeal arch http://purl.obolibrary.org/obo/MP_0006340 abnormal fourth pharyngeal arch morphology absence of the structure of the fourth arch which contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus http://purl.obolibrary.org/obo/MP_0010644 absent sixth pharyngeal arch http://purl.obolibrary.org/obo/MP_0006347 abnormal sixth pharyngeal arch morphology absence of the structure of the sixth arch which contributes to the development of the sternocleidomastoid and trapezius muscles http://purl.obolibrary.org/obo/MP_0010645 failure of conotruncal ridge closure http://purl.obolibrary.org/obo/MP_0010585 abnormal conotruncal ridge morphology failure of the conotruncal ridges to develop from the conotruncus, meet at the midline and fuse to form the conotruncal septum http://purl.obolibrary.org/obo/MP_0010646 absent pulmonary vein http://purl.obolibrary.org/obo/MP_0002726 abnormal pulmonary vein morphology absence of the veins that return oxygenated blood from the lungs to the left atrium of the heart http://purl.obolibrary.org/obo/MP_0010647 left atrium hypoplasia http://purl.obolibrary.org/obo/MP_0003923 abnormal heart left atrium morphology underdevelopment or reduced size of the left upper chamber of the heart, usually due to reduced cell number http://purl.obolibrary.org/obo/MP_0010648 right atrium hypoplasia http://purl.obolibrary.org/obo/MP_0003922 abnormal heart right atrium morphology underdevelopment or reduced size of the right upper chamber of the heart, usually due to reduced cell number http://purl.obolibrary.org/obo/MP_0010649 dilated pulmonary trunk http://purl.obolibrary.org/obo/MP_0000486 abnormal pulmonary trunk morphology the luminal space of the pulmonary trunk is increased in volume or area, usually with an increase of contained fluid http://purl.obolibrary.org/obo/MP_0010650 abnormal aorticopulmonary septum morphology http://purl.obolibrary.org/obo/MP_0006113 abnormal heart septum morphology any structural anomaly of the spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta http://purl.obolibrary.org/obo/MP_0010652 absent aorticopulmonary septum http://purl.obolibrary.org/obo/MP_0010651 aorticopulmonary septal defect absence of the spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta http://purl.obolibrary.org/obo/MP_0010653 abnormal Wallerian degeneration http://purl.obolibrary.org/obo/MP_0005164 abnormal response to injury any anomaly in the process of progressive degeneration of axons distal to an injury http://purl.obolibrary.org/obo/MP_0010654 slow Wallerian degeneration http://purl.obolibrary.org/obo/MP_0010653 abnormal Wallerian degeneration an increase in the length of time for the process of progressive degeneration of axons distal to an injury to occur http://purl.obolibrary.org/obo/MP_0010655 absent cardiac jelly http://purl.obolibrary.org/obo/MP_0009382 abnormal cardiac jelly morphology absence of the gelatinous noncellular material between the endothelial lining and the myocardial layer of the developing heart http://purl.obolibrary.org/obo/MP_0010656 thick myocardium http://purl.obolibrary.org/obo/MP_0005329 abnormal myocardium layer morphology increased thickness of the heart muscle layer http://purl.obolibrary.org/obo/MP_0010657 absent pulmonary trunk http://purl.obolibrary.org/obo/MP_0000486 abnormal pulmonary trunk morphology absence of the region of the pulmonary artery that arises from the right ventricle to the division of the right and left pulmonary artery http://purl.obolibrary.org/obo/MP_0010658 thoracic aorta aneurysm http://purl.obolibrary.org/obo/MP_0006278 aortic aneurysm a protruding sac formed by the dilation of the wall of the part of the aorta that extends from the origin at the heart to the diaphragm, resulting from a weakening of the vessel wall http://purl.obolibrary.org/obo/MP_0010659 abdominal aorta aneurysm http://purl.obolibrary.org/obo/MP_0009870 abnormal abdominal aorta morphology a protruding sac formed by the dilation of the wall of the part of the descending aorta that begins at the diaphragm and continues to the point of the common iliac arteries, resulting from a weakening of the vessel wall http://purl.obolibrary.org/obo/MP_0010660 descending thoracic aorta aneurysm http://purl.obolibrary.org/obo/MP_0010658 thoracic aorta aneurysm a protruding sac formed by the dilation of the wall of the of the part of the aorta that extends from the arch of the aorta to the diaphragm, resulting from a weakening of the vessel wall http://purl.obolibrary.org/obo/MP_0010661 ascending aorta aneurysm http://purl.obolibrary.org/obo/MP_0010658 thoracic aorta aneurysm a protruding sac formed by the dilation of the wall of the of the part of the aorta that arises from the base of the left ventricle and extends upward to the aortic arch, resulting from a weakening of the vessel wall http://purl.obolibrary.org/obo/MP_0010662 abnormal intersomitic artery morphology http://purl.obolibrary.org/obo/MP_0012253 abnormal intersomitic vessel morphology any structural anomaly of the small branching sprouts of the dorsal aorta that grow across the medial surface of the somite, turn right angles to grow over that surface and then fuse with other sprouts and form the vertebral arteries adjacent to the neural tube; the intersomitic arteries supply the body wall and persist in the adult as the posterior intercostal, subcostal and the lumbar arteries http://purl.obolibrary.org/obo/MP_0010663 abnormal brachiocephalic trunk morphology http://purl.obolibrary.org/obo/MP_0011655 abnormal systemic artery morphology any structural anomaly of the short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery http://purl.obolibrary.org/obo/MP_0010664 abnormal vitelline artery morphology http://purl.obolibrary.org/obo/MP_0003410 abnormal artery development any structural anomaly of the paired arteries that carry blood to the yolk sac from the dorsal aorta; the vitelline arteries give rise to the celiac artery, superior mesenteric artery, and inferior mesenteric artery in the adult http://purl.obolibrary.org/obo/MP_0010665 persistent vitelline artery http://purl.obolibrary.org/obo/MP_0010664 abnormal vitelline artery morphology failure of the vitelline arteries to regress and remodel into the celiac artery, superior mesenteric artery, and inferior mesenteric artery in the adult http://purl.obolibrary.org/obo/MP_0010666 abnormal vitelline vein morphology http://purl.obolibrary.org/obo/MP_0003411 abnormal vein development any structural anomaly of the paired veins that carry blood from the yolk sac back to the embryo http://purl.obolibrary.org/obo/MP_0010667 abnormal umbilical vein morphology http://purl.obolibrary.org/obo/MP_0012300 abnormal umbilical cord blood vessel morphology any structural anomaly of the vein that returns oxygenated blood from the placenta to the fetus through the umbilical cord http://purl.obolibrary.org/obo/MP_0010668 abnormal hepatic portal vein morphology http://purl.obolibrary.org/obo/MP_0002725 abnormal vein morphology any structural anomaly of the wide short vein formed from the confluence of the superior mesenteric, inferior mesenteric and splenic veins, and then divides into the right and left branches which ramify with the liver; the hepatic portal vein carries venous blood from the GI tract, spleen and pancreas to the liver http://purl.obolibrary.org/obo/MP_0010669 abnormal activation-induced B cell apoptosis http://purl.obolibrary.org/obo/MP_0008781 abnormal B cell apoptosis any anomaly in the process in which B cell apoptosis occurs upon engagement of either the B cell receptor or CD40, but not both; the engagement leads to expression of fas or related receptors that make the B cell susceptible to fas-ligand mediated death http://purl.obolibrary.org/obo/MP_0010670 abnormal activation-induced cell death of T cells http://purl.obolibrary.org/obo/MP_0006412 abnormal T cell apoptosis any anomaly in the process of the type of T cell apoptosis that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors http://purl.obolibrary.org/obo/MP_0010671 abnormal Tc17 cell morphology http://purl.obolibrary.org/obo/MP_0005010 abnormal CD8-positive, alpha beta T cell morphology any structural anomaly of a CD8-positive, alpha-beta positive T cell with the phenotype CCR6-positive, CCR5-high, CD45RA-negative, and secreting IL-17 and some IFNg http://purl.obolibrary.org/obo/MP_0010672 increased Tc17 cell number http://purl.obolibrary.org/obo/MP_0010671 abnormal Tc17 cell morphology increased cell number of a CD8-positive, alpha-beta positive T cell with the phenotype CCR6-positive, CCR5-high, CD45RA-negative, and secreting IL-17 and some IFNg http://purl.obolibrary.org/obo/MP_0010673 decreased Tc17 cell number http://purl.obolibrary.org/obo/MP_0010671 abnormal Tc17 cell morphology reduced cell number of a CD8-positive, alpha-beta positive T cell with the phenotype CCR6-positive, CCR5-high, CD45RA-negative, and secreting IL-17 and some IFNg http://purl.obolibrary.org/obo/MP_0010674 increased activation-induced B cell apoptosis http://purl.obolibrary.org/obo/MP_0010669 abnormal activation-induced B cell apoptosis increased frequency of B cell apoptosis that occurs upon engagement of either the B cell receptor or CD40, but not both; the engagement leads to expression of fas or related receptors that make the B cell susceptible to fas-ligand mediated death http://purl.obolibrary.org/obo/MP_0010675 decreased activation-induced B cell apoptosis http://purl.obolibrary.org/obo/MP_0010669 abnormal activation-induced B cell apoptosis decreased frequency of B cell apoptosis that occurs upon engagement of either the B cell receptor or CD40, but not both; the engagement leads to expression of fas or related receptors that make the B cell susceptible to fas-ligand mediated death http://purl.obolibrary.org/obo/MP_0010676 increased activation-induced cell death of T cells http://purl.obolibrary.org/obo/MP_0010670 abnormal activation-induced cell death of T cells increased frequency of the type of T cell apoptosis that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors http://purl.obolibrary.org/obo/MP_0010677 decreased activation-induced cell death of T cells http://purl.obolibrary.org/obo/MP_0010670 abnormal activation-induced cell death of T cells decreased frequency of the type of T cell apoptosis that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors http://purl.obolibrary.org/obo/MP_0010679 abnormal arrector pilli muscle morphology http://purl.obolibrary.org/obo/MP_0010678 abnormal skin adnexa morphology any structural anomaly of the bundles of smooth muscle fibers that connect the hair follicle with the papillary layer of the dermis, and serve to pull hair shafts erect http://purl.obolibrary.org/obo/MP_0010682 abnormal hair follicle infundibulum morphology http://purl.obolibrary.org/obo/MP_0000377 abnormal hair follicle morphology any structural anomaly of the most proximal part of the hair follicle relative to the epidermis, extending from the sebaceous duct to the epidermal surface http://purl.obolibrary.org/obo/MP_0010683 dilated hair follicle infundibulum http://purl.obolibrary.org/obo/MP_0010699 dilated hair follicles the luminal space of the hair follicle infundibulum is increased in volume or area, sometimes with an increase of contained fluid or sebum http://purl.obolibrary.org/obo/MP_0010687 absent hair follicle dermal papilla http://purl.obolibrary.org/obo/MP_0003813 abnormal hair follicle dermal papilla morphology absence of the mesodermal signaling center of the hair follicle consisting of closely packed specialized mesenchymal fibroblasts http://purl.obolibrary.org/obo/MP_0010688 hair follicle outer rooth sheath hyperplasia http://purl.obolibrary.org/obo/MP_0010684 abnormal hair follicle outer root sheath morphology overdevelopment or increased size, usually due to a increased number of cells, outermost layer of the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb http://purl.obolibrary.org/obo/MP_0010689 thin hair follicle outer rooth sheath http://purl.obolibrary.org/obo/MP_0010684 abnormal hair follicle outer root sheath morphology reduced thickness of the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb http://purl.obolibrary.org/obo/MP_0010690 thick hair follicle outer rooth sheath http://purl.obolibrary.org/obo/MP_0010684 abnormal hair follicle outer root sheath morphology increased thickness of the hair follicle that merges proximally with the basal layer of the interfollicular epidermis and distally with the hair bulb http://purl.obolibrary.org/obo/MP_0010691 hair follicle inner rooth sheath hyperplasia http://purl.obolibrary.org/obo/MP_0010685 abnormal hair follicle inner root sheath morphology overdevelopment or increased size, usually due to a increased number of cells, of the multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath http://purl.obolibrary.org/obo/MP_0010692 thick hair follicle inner rooth sheath http://purl.obolibrary.org/obo/MP_0010685 abnormal hair follicle inner root sheath morphology increased thickness of the multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath http://purl.obolibrary.org/obo/MP_0010693 thin hair follicle inner rooth sheath http://purl.obolibrary.org/obo/MP_0010685 abnormal hair follicle inner root sheath morphology reduced thickness of the multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath http://purl.obolibrary.org/obo/MP_0010694 abnormal hair follicle isthmus morphology http://purl.obolibrary.org/obo/MP_0000377 abnormal hair follicle morphology any structural anomaly of the middle part of the hair follicle that extends from the sebaceous duct to the bulge http://purl.obolibrary.org/obo/MP_0010695 abnormal blood pressure regulation http://purl.obolibrary.org/obo/MP_0001544 abnormal cardiovascular system physiology any anomaly in the process that modulates the force with which blood travels through the circulatory system, which is controlled by a balance of processes that increase pressure and decrease pressure http://purl.obolibrary.org/obo/MP_0010696 increased siderocyte number http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology the presence of abnormal red blood cells that have iron granule deposits that are not part of the hemoglobin http://purl.obolibrary.org/obo/MP_0010697 abnormal systemic arterial blood pressure regulation http://purl.obolibrary.org/obo/MP_0010695 abnormal blood pressure regulation anomaly in the process that modulates the force with which blood travels through the systemic arterial circulatory system http://purl.obolibrary.org/obo/MP_0010698 abnormal impulsive behavior control http://purl.obolibrary.org/obo/MP_0004924 abnormal behavior any anomaly in the ability of an individual to exert restraint over behavior http://purl.obolibrary.org/obo/MP_0010699 dilated hair follicles http://purl.obolibrary.org/obo/MP_0000377 abnormal hair follicle morphology the luminal space of the hair follicle is increased in volume or area, sometimes with an increase of contained fluid or sebum http://purl.obolibrary.org/obo/MP_0010700 hair follicle comedo http://purl.obolibrary.org/obo/MP_0000377 abnormal hair follicle morphology a dilated or widened hair follicle filled with keratin squamae (skin debris), bacteria, and/or sebum (oil) http://purl.obolibrary.org/obo/MP_0010701 fusion of atlas and odontoid process http://purl.obolibrary.org/obo/MP_0004659 abnormal odontoid process morphology the large protuberance that projects upward from the cervical axis (C2), around which the cervical atlas normally rotates, is instead fused to elements of the atlas; the odontoid process may or may not remain attached to the axis http://purl.obolibrary.org/obo/MP_0010702 split cervical atlas http://purl.obolibrary.org/obo/MP_0004607 abnormal cervical atlas morphology the first (topmost, C1) cervical vertebra is divided into two branches by a median cleft http://purl.obolibrary.org/obo/MP_0010703 split cervical axis http://purl.obolibrary.org/obo/MP_0004608 abnormal cervical axis morphology the second cervical vertebra (C2) is divided into two branches by a median cleft http://purl.obolibrary.org/obo/MP_0010704 abnormal optic canal morphology http://purl.obolibrary.org/obo/MP_0004457 abnormal orbitosphenoid bone morphology any structural anomaly of the short canal through the orbitosphenoid bone at the apex of the orbit that gives passage to the optic nerve and the opthalmic artery http://purl.obolibrary.org/obo/MP_0010705 absent metoptic pilar http://purl.obolibrary.org/obo/MP_0010704 abnormal optic canal morphology absence of the posterior border of the optic nerve foramen http://purl.obolibrary.org/obo/MP_0010706 ventral rotation of lens http://purl.obolibrary.org/obo/MP_0001308 abnormal lens polarity a circular shift toward the ventral pole in the position of the equator of the lens relative to the optic nerve exit point http://purl.obolibrary.org/obo/MP_0010707 decreased ventral retina size http://purl.obolibrary.org/obo/MP_0001325 abnormal retina morphology decreasd size of the ventral portion of the retina http://purl.obolibrary.org/obo/MP_0010708 absent iris stroma http://purl.obolibrary.org/obo/MP_0005208 abnormal iris stroma morphology absence of the lamellated vascular connective tissue of the iris http://purl.obolibrary.org/obo/MP_0010709 absent anterior chamber http://purl.obolibrary.org/obo/MP_0005205 abnormal eye anterior chamber morphology absence of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens http://purl.obolibrary.org/obo/MP_0010710 absent sclera http://purl.obolibrary.org/obo/MP_0002698 abnormal sclera morphology absence of the fibrous, outer envelope of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea http://purl.obolibrary.org/obo/MP_0010711 persistent hyperplastic primary vitreous http://purl.obolibrary.org/obo/MP_0009620 abnormal primary vitreous morphology persistence of the embryonic fibrovascular mesodermal tissue located between the optic cup and lens vesicle that normally regresses during the development of the vitreous body http://purl.obolibrary.org/obo/MP_0010712 absent nasolacrimal duct http://purl.obolibrary.org/obo/MP_0008969 abnormal nasolacrimal duct morphology absence of the paired channels leading from the lacrimal sacs to the inferior meatus of the nose, through which tears are conducted through the nasal cavity http://purl.obolibrary.org/obo/MP_0010713 corneal-lenticular stalk http://purl.obolibrary.org/obo/MP_0001312 abnormal cornea morphology persistent central adhesion between the lens and the cornea http://purl.obolibrary.org/obo/MP_0010714 iris coloboma http://purl.obolibrary.org/obo/MP_0012533 uveal coloboma congenital defect of the iris in which some part of the structure is absent http://purl.obolibrary.org/obo/MP_0010715 retina coloboma http://purl.obolibrary.org/obo/MP_0005262 coloboma congenital defect of the retina in which some part of the structure is absent http://purl.obolibrary.org/obo/MP_0010716 optic disc coloboma http://purl.obolibrary.org/obo/MP_0008259 abnormal optic disc morphology congenital defect of the optic disc in which some part of the structure is absent http://purl.obolibrary.org/obo/MP_0010717 optic nerve coloboma http://purl.obolibrary.org/obo/MP_0005262 coloboma congenital defect of the optic nerve in which some part of the structure is absent http://purl.obolibrary.org/obo/MP_0010718 choroid coloboma http://purl.obolibrary.org/obo/MP_0012533 uveal coloboma congenital defect of the choroid and retinal pigment epithelium in which some part of the structures are absent, exposing the sclera; the defect is usually situated below the optic disk in the region of fetal (choroid) fissure http://purl.obolibrary.org/obo/MP_0010719 ciliary body coloboma http://purl.obolibrary.org/obo/MP_0012533 uveal coloboma congenital defect of the ciliary body in which some part of the structure is absent http://purl.obolibrary.org/obo/MP_0010720 absent sublingual duct http://purl.obolibrary.org/obo/MP_0009527 abnormal sublingual duct morphology absence of the canals that drain the sublingual gland http://purl.obolibrary.org/obo/MP_0010721 short sublingual duct http://purl.obolibrary.org/obo/MP_0009527 abnormal sublingual duct morphology decreased length of the canals that drain the sublingual gland http://purl.obolibrary.org/obo/MP_0010722 persistent cervical thymus http://purl.obolibrary.org/obo/MP_0000704 abnormal thymus development the solid lobe of the thymus fails to descend to the mediastinum http://purl.obolibrary.org/obo/MP_0010723 paternal effect http://purl.obolibrary.org/obo/MP_0005395 other phenotype expression of a phenotypic trait in a male animal's offspring that is dependent on the paternal genotype http://purl.obolibrary.org/obo/MP_0010724 thick interventricular septum http://purl.obolibrary.org/obo/MP_0020136 abnormal interventricular septum thickness increased thickness of the wall between the two lower chambers of the heart http://purl.obolibrary.org/obo/MP_0010725 thin interventricular septum http://purl.obolibrary.org/obo/MP_0020136 abnormal interventricular septum thickness decreased thickness of the wall between the two lower chambers of the heart http://purl.obolibrary.org/obo/MP_0010727 increased glioblastoma incidence http://purl.obolibrary.org/obo/MP_0010278 increased glioma incidence greater than the expected number of a fast-growing type of central nervous system tumor that forms from glial tissue of the brain and spinal cord and has cells that look very different from normal cells; glioblastoma usually occurs in adults and affects the brain more often than the spinal cord http://purl.obolibrary.org/obo/MP_0010728 fusion of atlas and occipital bones http://purl.obolibrary.org/obo/MP_0004607 abnormal cervical atlas morphology union of elements of the atlas and the bone at the lower, posterior part of the skull into one structure http://purl.obolibrary.org/obo/MP_0010729 absent arcus anterior http://purl.obolibrary.org/obo/MP_0009879 abnormal arcus anterior morphology absence of the arch that connects the lateral masses of the atlas anteriorly and articulates with the anterior articular facet of the dens of the axis http://purl.obolibrary.org/obo/MP_0010730 absent odontoid process http://purl.obolibrary.org/obo/MP_0004659 abnormal odontoid process morphology absence of the large protuberance that projects upward from the cervical axis, around which the cervical atlas rotates http://purl.obolibrary.org/obo/MP_0010731 absent ventral tubercle of atlas http://purl.obolibrary.org/obo/MP_0004658 abnormal ventral tubercle of atlas morphology absence of the conical ventral projection on the arch of the atlas http://purl.obolibrary.org/obo/MP_0010732 abnormal node of Ranvier morphology http://purl.obolibrary.org/obo/MP_0005404 abnormal axon morphology any structural anomaly of the short unmyelinated segments of an axon between myelinated segments, where voltage gated channels accumulate and regenerate an action potential as it is conducted along the axon http://purl.obolibrary.org/obo/MP_0010733 abnormal axon initial segment morphology http://purl.obolibrary.org/obo/MP_0005404 abnormal axon morphology any structural anomaly of the short unmyelinated axon segment adjacent to the cell soma where voltage gated channels accumulate and axon potential initiation usually occurs http://purl.obolibrary.org/obo/MP_0010734 abnormal paranode morphology http://purl.obolibrary.org/obo/MP_0005404 abnormal axon morphology any structural anomaly of the axon region immediately adjacent to nodes of Ranvier, where a series of cytoplasmic loops from the overlying glial cell form septate-like junctions with the axon; the axoglial junctions act as a diffusion barrier between the node and internode http://purl.obolibrary.org/obo/MP_0010735 abnormal paranodal axoglial junction morphology http://purl.obolibrary.org/obo/MP_0010734 abnormal paranode morphology any structural anomaly of the structure in which the myelin sheath attaches to the axon at each end of each myelin segment; the axoglial junctions act as a diffusion barrier between the node and internode, maintaining domain-specific axolemmal membrane components http://purl.obolibrary.org/obo/MP_0010737 abnormal juxtaparanode morphology http://purl.obolibrary.org/obo/MP_0005404 abnormal axon morphology any structural anomaly of the region of an axon near a node of Ranvier that is between the paranode axoglial junction and the internode regions; the juxtaparanode axolemma is enriched in potassium channels http://purl.obolibrary.org/obo/MP_0010738 abnormal internode morphology http://purl.obolibrary.org/obo/MP_0005404 abnormal axon morphology any structural anomaly of the intervening axon segment that is located between the juxtaparanodes and is surrounded by a single compact myelin sheath http://purl.obolibrary.org/obo/MP_0010739 abnormal axolemma morphology http://purl.obolibrary.org/obo/MP_0005404 abnormal axon morphology any structural anomaly of the plasma membrane of an axon http://purl.obolibrary.org/obo/MP_0010740 abnormal dendritic cell chemotaxis http://purl.obolibrary.org/obo/MP_0011518 abnormal cell chemotaxis anomaly in the movement of a dendritic cell in response to an external stimulus http://purl.obolibrary.org/obo/MP_0010741 abnormal melanocyte proliferation http://purl.obolibrary.org/obo/MP_0001186 pigmentation phenotype anomaly in the ability of the a melanocyte cell population to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0010742 increased Schwann cell number http://purl.obolibrary.org/obo/MP_0001106 abnormal Schwann cell morphology greater than normal number of cells that sheath the axons of the peripheral nervous system http://purl.obolibrary.org/obo/MP_0010743 delayed suture closure http://purl.obolibrary.org/obo/MP_0003420 delayed intramembranous bone ossification late onset of the fusion of the bones of the skull http://purl.obolibrary.org/obo/MP_0010744 abnormal cervical flexure morphology http://purl.obolibrary.org/obo/MP_0000913 abnormal brain development any structural anomaly in the ventrally concave flexure of the embryonic brain occurring at the junction of hindbrain and spinal cord http://purl.obolibrary.org/obo/MP_0010745 abnormal pre-Botzinger complex morphology http://purl.obolibrary.org/obo/MP_0001033 abnormal parasympathetic system morphology any structural anomaly of the group of interneurons within the medulla oblongata's ventral respiratory group that are important for the generation of ventilatory (inspiratory) rhythmogenesis http://purl.obolibrary.org/obo/MP_0010746 abnormal pre-Botzinger complex physiology http://purl.obolibrary.org/obo/MP_0006277 abnormal parasympathetic nervous system physiology any functional anomaly of the group of interneurons within the medulla oblongata's ventral respiratory group that are important for the generation of ventilatory (inspiratory) rhythmogenesis http://purl.obolibrary.org/obo/MP_0010747 abnormal enamel organ morphology http://purl.obolibrary.org/obo/MP_0000116 abnormal tooth development any structural anomaly of the circumscribed mass of ectodermal cells which bud off from the dental lamina; it becomes cup-shaped and develops on its internal face the ameloblast layer of cells that produces the enamel cap of a developing tooth http://purl.obolibrary.org/obo/MP_0010748 abnormal visual evoked potential http://purl.obolibrary.org/obo/MP_0005551 abnormal eye electrophysiology anomaly in the electroencephalographic pattern recorded from the occipital area generated in response to retinal stimulation such as flashing lights or inverting a contrasting image; may be used to evaluate optic nerve damage or visual perception http://purl.obolibrary.org/obo/MP_0010749 absent visual evoked potential http://purl.obolibrary.org/obo/MP_0010748 abnormal visual evoked potential absence of a characteristic electroencephalographic pattern recorded from the occipital area generated in response to retinal stimulation such as flashing lights or inverting a contrasting image; absence may indicate blindness http://purl.obolibrary.org/obo/MP_0010750 increased susceptibility to parasitic infection induced morbidity/mortality http://purl.obolibrary.org/obo/MP_0009787 increased susceptibility to infection induced morbidity/mortality increased likelihood that an organism will display the expected moribund state caused by a parasitic invasion or from components of or toxins produced by parasites http://purl.obolibrary.org/obo/MP_0010751 decreased susceptibility to parasitic infection induced morbidity/mortality http://purl.obolibrary.org/obo/MP_0009786 decreased susceptibility to infection induced morbidity/mortality decreased likelihood that an organism will display the expected moribund state caused by a parasitic invasion or from components of or toxins produced by parasites http://purl.obolibrary.org/obo/MP_0010752 impaired mucociliary clearance http://purl.obolibrary.org/obo/MP_0001947 abnormal mucociliary clearance reduced ability to remove mucus and other foreign particles and microorganisms from the lungs by directed ciliary movement and secretory activity of the tracheobronchial submucosal glands http://purl.obolibrary.org/obo/MP_0010753 improved mucociliary clearance http://purl.obolibrary.org/obo/MP_0001947 abnormal mucociliary clearance enhanced ability to remove mucus and other foreign particles and microorganisms from the lungs by directed ciliary movement and secretory activity of the tracheobronchial submucosal glands http://purl.obolibrary.org/obo/MP_0010755 abnormal heart right ventricle pressure http://purl.obolibrary.org/obo/MP_0008775 abnormal heart ventricle pressure any anomaly in the pressure within the right cardiac ventricle http://purl.obolibrary.org/obo/MP_0010756 decreased right ventricle peak pressure http://purl.obolibrary.org/obo/MP_0010755 abnormal heart right ventricle pressure decrease in the difference between right ventricular systolic and diastolic pressures http://purl.obolibrary.org/obo/MP_0010757 decreased right ventricle diastolic pressure http://purl.obolibrary.org/obo/MP_0010755 abnormal heart right ventricle pressure decrease in the pressure of the right ventricle between heart beats when the heart is relaxed http://purl.obolibrary.org/obo/MP_0010758 increased right ventricle systolic pressure http://purl.obolibrary.org/obo/MP_0010755 abnormal heart right ventricle pressure increase in the pressure in the right ventricle as the heart contracts and pumps blood into the arteries http://purl.obolibrary.org/obo/MP_0010759 decreased right ventricle systolic pressure http://purl.obolibrary.org/obo/MP_0010755 abnormal heart right ventricle pressure decrease in the pressure in the right ventricle as the heart contracts and pumps blood into the arteries http://purl.obolibrary.org/obo/MP_0010761 abnormal microglial cell chemotaxis http://purl.obolibrary.org/obo/MP_0010760 abnormal macrophage chemotaxis anomaly in the movement of a microglial cell guided by a specific chemical concentration gradient http://purl.obolibrary.org/obo/MP_0010762 abnormal microglial cell activation http://purl.obolibrary.org/obo/MP_0003691 abnormal microglial cell physiology any anomaly in change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form http://purl.obolibrary.org/obo/MP_0010763 abnormal hematopoietic stem cell physiology http://purl.obolibrary.org/obo/MP_0001545 abnormal hematopoietic system physiology any functional anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages http://purl.obolibrary.org/obo/MP_0010764 abnormal granulocyte chemotaxis http://purl.obolibrary.org/obo/MP_0011518 abnormal cell chemotaxis anomaly in the movement of a granulocyte guided by a specific chemical concentration gradient http://purl.obolibrary.org/obo/MP_0010765 impaired granulocyte chemotaxis http://purl.obolibrary.org/obo/MP_0010764 abnormal granulocyte chemotaxis reduced ability in the movement of a granulocyte guided by a specific chemical concentration gradient http://purl.obolibrary.org/obo/MP_0010766 abnormal NK cell physiology http://purl.obolibrary.org/obo/MP_0003945 abnormal lymphocyte physiology any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells http://purl.obolibrary.org/obo/MP_0010767 abnormal female meiosis I arrest http://purl.obolibrary.org/obo/MP_0005168 abnormal female meiosis any anomaly in the process in which oocytes stop at the diplotene stage of meiosis I and lie dormant, often for long periods of time http://purl.obolibrary.org/obo/MP_0010772 abnormal pollex morphology http://purl.obolibrary.org/obo/MP_0002110 abnormal digit morphology any structural anomaly of the first or primary digit on the radial side of the hand http://purl.obolibrary.org/obo/MP_0010773 supernumerary molars http://purl.obolibrary.org/obo/MP_0004033 supernumerary teeth increased number of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface http://purl.obolibrary.org/obo/MP_0010774 abnormal lymph node follicular mantle morphology http://purl.obolibrary.org/obo/MP_0002346 abnormal lymph node secondary follicle morphology any structural anomaly of the part of the secondary follicle in which naive B cells reside along with some helper T cells, macrophages and follicular dendritic cells; these are displaced by the expanding germinal centre and form a 'mantle' around it http://purl.obolibrary.org/obo/MP_0010775 abnormal scaphoid morphology http://purl.obolibrary.org/obo/MP_0000554 abnormal carpal bone morphology any structural anomaly of the bone of the hand located at the radial side of the carpus and which articulates with the radius, trapezium, trapezoideum, capitate, and lunate bones http://purl.obolibrary.org/obo/MP_0010776 abnormal placenta metrial gland morphology http://purl.obolibrary.org/obo/MP_0013324 abnormal female reproductive gland morphology any structural anomaly in the group of granular epithelial cells in the uterine muscle beneath the placenta that develops during pregnancy in rodents and some other species, but not in primates http://purl.obolibrary.org/obo/MP_0010777 absent placenta metrial gland http://purl.obolibrary.org/obo/MP_0010776 abnormal placenta metrial gland morphology absence of the group of granular epithelial cells in the uterine muscle beneath the placenta that develops during pregnancy in rodents and some other species, but not in primates http://purl.obolibrary.org/obo/MP_0010778 abnormal stomach fundus morphology http://purl.obolibrary.org/obo/MP_0000470 abnormal stomach morphology any structural anomaly of the region of the stomach that lies above the cardiac notch that functions to store undigested food and to collect stomach gases produced by chemical digestion http://purl.obolibrary.org/obo/MP_0010779 abnormal stomach muscularis externa morphology http://purl.obolibrary.org/obo/MP_0010783 abnormal stomach wall morphology any structural anomaly of the smooth muscle layer of the stomach wall that functions to churn and mix food and gastric secretions as well as to move food along the digestive tract to the intestines http://purl.obolibrary.org/obo/MP_0010780 abnormal stomach smooth muscle circular layer morphology http://purl.obolibrary.org/obo/MP_0010779 abnormal stomach muscularis externa morphology any structural anomaly of the middle layer of the muscularis; it is continuous with the circular layer of the esophagus, but is absent in the fundus and lies concentric to the longitudinal axis of the stomach; the circular layer is normally tonically constricted forming a functional pyloric sphincter, which controls the movement of chyme into the duodenum http://purl.obolibrary.org/obo/MP_0010781 pyloric sphincter hypertrophy http://purl.obolibrary.org/obo/MP_0009861 abnormal pyloric sphincter morphology increase in the bulk size of the thick circular layer of gastric musculature encircling the gastroduodenal junction at the gastric outlet of the stomach, due to cell enlargement or accumulation of fluids http://purl.obolibrary.org/obo/MP_0010782 stomach smooth muscle circular layer hypertrophy http://purl.obolibrary.org/obo/MP_0010780 abnormal stomach smooth muscle circular layer morphology increase in the bulk size of the middle layer of the muscularis due to cell enlargement or accumulation of fluids http://purl.obolibrary.org/obo/MP_0010783 abnormal stomach wall morphology http://purl.obolibrary.org/obo/MP_0000470 abnormal stomach morphology any structural anomaly of the layered structure that makes up the stomach, consisting of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between http://purl.obolibrary.org/obo/MP_0010784 abnormal forestomach morphology http://purl.obolibrary.org/obo/MP_0000470 abnormal stomach morphology any structural anomaly of the dilated area of tissue where the stomach and esophagus meet http://purl.obolibrary.org/obo/MP_0010786 stomach fundus hypertrophy http://purl.obolibrary.org/obo/MP_0010778 abnormal stomach fundus morphology increase in the bulk size of the stomach fundus due to cell enlargement or accumulation of fluids http://purl.obolibrary.org/obo/MP_0010787 gastric cysts http://purl.obolibrary.org/obo/MP_0000470 abnormal stomach morphology abnormal membranous sacs in the wall of the stomach http://purl.obolibrary.org/obo/MP_0010788 stomach hypoplasia http://purl.obolibrary.org/obo/MP_0002691 small stomach underdevelopment or reduced size, usually due to a reduced number of cells, of the stomach http://purl.obolibrary.org/obo/MP_0010789 abnormal stomach mesentery morphology http://purl.obolibrary.org/obo/MP_0000470 abnormal stomach morphology any structural anomaly of the double layer of peritoneum that encloses the stomach and connects it to the abdominal wall http://purl.obolibrary.org/obo/MP_0010790 abnormal stomach pyloric antrum morphology http://purl.obolibrary.org/obo/MP_0010785 abnormal stomach pyloric region morphology any structural anomaly of the area at the bottom of the stomach on the caudal side of the pyloric canal that contains gastrin-producing G cells, which stimulate acid production, and the luminal pH-sensitive population of somatostatin-producing D cells http://purl.obolibrary.org/obo/MP_0010791 abnormal pyloric canal morphology http://purl.obolibrary.org/obo/MP_0010785 abnormal stomach pyloric region morphology any structural anomaly of the short narrow part of the stomach extending from the pyloric antrum to the pyloric sphincter http://purl.obolibrary.org/obo/MP_0010793 abnormal stomach serosa morphology http://purl.obolibrary.org/obo/MP_0010783 abnormal stomach wall morphology any structural anomaly of the outermost layer of the stomach wall, consisting of layers of connective tissue continuous with the peritoneum http://purl.obolibrary.org/obo/MP_0010794 abnormal stomach submucosa morphology http://purl.obolibrary.org/obo/MP_0010783 abnormal stomach wall morphology any structural anomaly of the fibrous connective tissue layer beneath the stomach mucosa http://purl.obolibrary.org/obo/MP_0010795 abnormal cardiac gastric gland morphology http://purl.obolibrary.org/obo/MP_0010798 abnormal stomach cardiac region morphology any structural anomaly of the gastric glands in the cardiac region of the stomach; cardiac glands are fewer in number than in the fundus and body, and secrete mucin which coats the stomach and protects it http://purl.obolibrary.org/obo/MP_0010796 abnormal intermediate gastric gland morphology http://purl.obolibrary.org/obo/MP_0003892 abnormal gastric gland morphology any structural anomaly of any of the branched tubular glands in the mucosa of the fundus and body of the stomach that secrete most of the digestive substances secreted by the stomach http://purl.obolibrary.org/obo/MP_0010797 abnormal pyloric gastric gland morphology http://purl.obolibrary.org/obo/MP_0010785 abnormal stomach pyloric region morphology any structural anomaly of the gastric glands in the pyloric region of the stomach; the pyloric glands secrete mucin, which coats the stomach and protects it, and hormones such as gastrin and enkephalin http://purl.obolibrary.org/obo/MP_0010798 abnormal stomach cardiac region morphology http://purl.obolibrary.org/obo/MP_0000470 abnormal stomach morphology any structural anomaly of the stomach region where the esophagus empties into the stomach http://purl.obolibrary.org/obo/MP_0010799 stomach mucosa hyperplasia http://purl.obolibrary.org/obo/MP_0010792 abnormal stomach mucosa morphology overdevelopment or increased size, usually due to an increase in the number of cells, of the mucous layer of the stomach wall which contains the gastric pits and glands, and consists of epithelium, lamina propria, and the muscularis mucosae http://purl.obolibrary.org/obo/MP_0010800 abnormal submucous nerve plexus morphology http://purl.obolibrary.org/obo/MP_0001044 abnormal enteric nervous system morphology any structural anomaly of the gangliated plexus of unmyelinated nerve fibers that ramify the stomach and intestinal submucosa http://purl.obolibrary.org/obo/MP_0010801 abnormal myenteric nerve plexus morphology http://purl.obolibrary.org/obo/MP_0001044 abnormal enteric nervous system morphology any structural anomaly of the plexus of unmyelinated nerve fibers and postganglionic autonomic cell bodies lying in the muscular coat of the esophagus, stomach and intestines that communicate with the submucosal, subserosal and enteric plexuses http://purl.obolibrary.org/obo/MP_0010802 abnormal intestinal enteroendocrine cell morphology http://purl.obolibrary.org/obo/MP_0004141 abnormal enteroendocrine cell morphology any structural anomaly of the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract http://purl.obolibrary.org/obo/MP_0010803 abnormal stomach enteroendocrine cell morphology http://purl.obolibrary.org/obo/MP_0004141 abnormal enteroendocrine cell morphology any structural anomaly of the various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach http://purl.obolibrary.org/obo/MP_0010804 abnormal stomach smooth muscle inner oblique layer morphology http://purl.obolibrary.org/obo/MP_0010779 abnormal stomach muscularis externa morphology any structural anomaly of the innermost layer of the muscularis; it is not present in all sections of the stomach but is clearly seen in the fundus and near the lesser curvature of the corpus; the oblique fibers disappear distally (towards the pyloric antrum); the oblique layer is responsible for creating the motion that churns and physically breaks down the food http://purl.obolibrary.org/obo/MP_0010805 abnormal stomach smooth muscle outer longitudinal layer morphology http://purl.obolibrary.org/obo/MP_0010779 abnormal stomach muscularis externa morphology any structural anomaly of the most superficial layer of the muscularis; it has two sections, a longitudinal layer that is common with the esophagus and ends in the corpus, and a longitudinal layer that originates in the corpus and spreads into the duodenum http://purl.obolibrary.org/obo/MP_0010806 abnormal stomach muscularis mucosa morphology http://purl.obolibrary.org/obo/MP_0010792 abnormal stomach mucosa morphology any structural anomaly of the thin layer of smooth muscle in the mucosal layer of the stomach that functions to agitate the surface area stomach mucosa by moving the villi back and forth http://purl.obolibrary.org/obo/MP_0010807 abnormal stomach position or orientation http://purl.obolibrary.org/obo/MP_0003283 abnormal digestive organ placement the stomach is displaced from the normal left-sided position and/or orientation http://purl.obolibrary.org/obo/MP_0010808 right-sided stomach http://purl.obolibrary.org/obo/MP_0010807 abnormal stomach position or orientation stomach is present on the right side of the body instead of the left http://purl.obolibrary.org/obo/MP_0010809 abnormal Clara cell morphology http://purl.obolibrary.org/obo/MP_0010897 abnormal bronchiole epithelium morphology any structural anomaly of the rounded, club-shaped, nonciliated cell protruding between ciliated cells in bronchiolar epithelium, believed to be secretory in function http://purl.obolibrary.org/obo/MP_0010810 increased type II pneumocyte number http://purl.obolibrary.org/obo/MP_0002275 abnormal type II pneumocyte morphology greater number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored http://purl.obolibrary.org/obo/MP_0010811 decreased type II pneumocyte number http://purl.obolibrary.org/obo/MP_0002275 abnormal type II pneumocyte morphology reduced number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored http://purl.obolibrary.org/obo/MP_0010812 absent type II pneumocytes http://purl.obolibrary.org/obo/MP_0010811 decreased type II pneumocyte number absence of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored http://purl.obolibrary.org/obo/MP_0010813 abnormal alveolar lamellar body morphology http://purl.obolibrary.org/obo/MP_0002275 abnormal type II pneumocyte morphology any structural anomaly of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant http://purl.obolibrary.org/obo/MP_0010814 absent alveolar lamellar bodies http://purl.obolibrary.org/obo/MP_0010813 abnormal alveolar lamellar body morphology absence of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant http://purl.obolibrary.org/obo/MP_0010815 enlarged alveolar lamellar bodies http://purl.obolibrary.org/obo/MP_0010813 abnormal alveolar lamellar body morphology increased size of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant http://purl.obolibrary.org/obo/MP_0010816 decreased type I pneumocyte number http://purl.obolibrary.org/obo/MP_0002274 abnormal type I pneumocyte morphology reduced number of the flattened, branched squamous cells that covers more than 98 percent of the alveolar surface, and have thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange http://purl.obolibrary.org/obo/MP_0010817 absent type I pneumocytes http://purl.obolibrary.org/obo/MP_0010816 decreased type I pneumocyte number absence of the flattened, branched squamous cells that covers more than 98 percent of the alveolar surface, and have thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange http://purl.obolibrary.org/obo/MP_0010818 adhesive atelectasis http://purl.obolibrary.org/obo/MP_0001177 atelectasis alveolar collapse in the presence of patent airways, especially when surfactant is inactivated or absent, and is seen in newborn respiratory distress syndrome, acute radiation pneumonitis, or viral pneumonia http://purl.obolibrary.org/obo/MP_0010819 primary atelectasis http://purl.obolibrary.org/obo/MP_0001177 atelectasis nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration http://purl.obolibrary.org/obo/MP_0010820 abnormal pleura morphology http://purl.obolibrary.org/obo/MP_0002132 abnormal respiratory system morphology any structural anomaly of the serous membrane surrounding the lungs and lining the walls of the pleural cavity http://purl.obolibrary.org/obo/MP_0010821 abnormal visceral pleura morphology http://purl.obolibrary.org/obo/MP_0010820 abnormal pleura morphology any structural anomaly of the pleura layer attached to and covering the lungs, and which intercalates into the fissures between the lobes http://purl.obolibrary.org/obo/MP_0010822 pneumothorax http://purl.obolibrary.org/obo/MP_0002133 abnormal respiratory system physiology free air or gas is present in the pleural cavity http://purl.obolibrary.org/obo/MP_0010823 abnormal parietal pleura morphology http://purl.obolibrary.org/obo/MP_0010820 abnormal pleura morphology any structural anomaly of the part of the pleura that lines and is attached to the wall of the thoracic cavity http://purl.obolibrary.org/obo/MP_0010824 absent right lung accessory lobe http://purl.obolibrary.org/obo/MP_0009571 abnormal right lung accessory lobe morphology absence of the right lung lobe which lies against the diaphragm and has a considerable volume residing in the left hemi-thorax http://purl.obolibrary.org/obo/MP_0010825 abnormal lung saccule morphology http://purl.obolibrary.org/obo/MP_0001176 abnormal lung development any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth http://purl.obolibrary.org/obo/MP_0010826 absent lung saccules http://purl.obolibrary.org/obo/MP_0010825 abnormal lung saccule morphology absence of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth http://purl.obolibrary.org/obo/MP_0010827 small lung saccule http://purl.obolibrary.org/obo/MP_0010825 abnormal lung saccule morphology reduced size of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth http://purl.obolibrary.org/obo/MP_0010828 abnormal bronchioalveolar stem cell morphology http://purl.obolibrary.org/obo/MP_0006382 abnormal lung epithelium morphology any structural anomaly of a respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole, which gives rise to alveolar cell types and Clara cells in response to lung injury http://purl.obolibrary.org/obo/MP_0010829 increased bronchioalveolar stem cell number http://purl.obolibrary.org/obo/MP_0010828 abnormal bronchioalveolar stem cell morphology greater numbers of a respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole, which gives rise to alveolar cell types and Clara cells in response to lung injury http://purl.obolibrary.org/obo/MP_0010830 decreased bronchioalveolar stem cell number http://purl.obolibrary.org/obo/MP_0010828 abnormal bronchioalveolar stem cell morphology reduced numbers of a respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole, which gives rise to alveolar cell types and Clara cells in response to lung injury http://purl.obolibrary.org/obo/MP_0010831 partial lethality http://purl.obolibrary.org/obo/MP_0010769 abnormal survival the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms http://purl.obolibrary.org/obo/MP_0010833 abnormal memory T cell morphology http://purl.obolibrary.org/obo/MP_0008037 abnormal T cell morphology any structural anomaly of distinctly differentiated long-lived T cells that have the phenotype CD45RO-positive and CD127-positive http://purl.obolibrary.org/obo/MP_0010834 abnormal CD4-positive, alpha-beta memory T cell morphology http://purl.obolibrary.org/obo/MP_0010833 abnormal memory T cell morphology any structural anomaly of a CD4-positive, alpha-beta long-lived T cell with the phenotype CD45RO-positive and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high http://purl.obolibrary.org/obo/MP_0010835 increased CD4-positive, alpha-beta memory T cell number http://purl.obolibrary.org/obo/MP_0012769 abnormal CD4-positive, alpha-beta memory T cell number increased number of CD4-positive, alpha-beta long-lived T cells with the phenotype CD45RO-positive and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high http://purl.obolibrary.org/obo/MP_0010836 decreased CD4-positive, alpha-beta memory T cell number http://purl.obolibrary.org/obo/MP_0012769 abnormal CD4-positive, alpha-beta memory T cell number reduced number of CD4-positive, alpha-beta long-lived T cells with the phenotype CD45RO-positive and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high http://purl.obolibrary.org/obo/MP_0010837 abnormal CD8-positive, alpha-beta memory T cell morphology http://purl.obolibrary.org/obo/MP_0010833 abnormal memory T cell morphology any structural anomaly of a CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high http://purl.obolibrary.org/obo/MP_0010838 increased CD8-positive, alpha-beta memory T cell number http://purl.obolibrary.org/obo/MP_0012774 abnormal CD8-positive, alpha-beta memory T cell number increased number of CD8-positive, alpha-beta T cells with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high http://purl.obolibrary.org/obo/MP_0010839 decreased CD8-positive, alpha-beta memory T cell number http://purl.obolibrary.org/obo/MP_0012774 abnormal CD8-positive, alpha-beta memory T cell number decreased number of CD8-positive, alpha-beta T cells with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high http://purl.obolibrary.org/obo/MP_0010840 abnormal central memory CD4-positive, alpha-beta T cell morphology http://purl.obolibrary.org/obo/MP_0010834 abnormal CD4-positive, alpha-beta memory T cell morphology any structural anomaly of a CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative http://purl.obolibrary.org/obo/MP_0010841 increased central memory CD4-positive, alpha-beta T cell number http://purl.obolibrary.org/obo/MP_0012771 abnormal central memory CD4-positive, alpha-beta T cell number increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative http://purl.obolibrary.org/obo/MP_0010842 decreased central memory CD4-positive, alpha-beta T cell number http://purl.obolibrary.org/obo/MP_0012771 abnormal central memory CD4-positive, alpha-beta T cell number reduced number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative http://purl.obolibrary.org/obo/MP_0010843 abnormal effector memory CD4-positive, alpha-beta T cell morphology http://purl.obolibrary.org/obo/MP_0010834 abnormal CD4-positive, alpha-beta memory T cell morphology any structural anomaly of a CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative http://purl.obolibrary.org/obo/MP_0010844 increased effector memory CD4-positive, alpha-beta T cell number http://purl.obolibrary.org/obo/MP_0012770 abnormal effector memory CD4-positive, alpha-beta T cell number increased number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative http://purl.obolibrary.org/obo/MP_0010845 decreased effector memory CD4-positive, alpha-beta T cell number http://purl.obolibrary.org/obo/MP_0012770 abnormal effector memory CD4-positive, alpha-beta T cell number reduced number of CD4-positive, alpha-beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative http://purl.obolibrary.org/obo/MP_0010846 abnormal central memory CD8 positive, alpha-beta T cell morphology http://purl.obolibrary.org/obo/MP_0010837 abnormal CD8-positive, alpha-beta memory T cell morphology any structural anomaly of a CD8-positive, alpha beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative http://purl.obolibrary.org/obo/MP_0010847 increased central memory CD8 positive, alpha-beta T cell number http://purl.obolibrary.org/obo/MP_0012772 abnormal central memory CD8-positive, alpha-beta T cell number increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative http://purl.obolibrary.org/obo/MP_0010848 decreased central memory CD8 positive, alpha-beta T cell number http://purl.obolibrary.org/obo/MP_0012772 abnormal central memory CD8-positive, alpha-beta T cell number reduced number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative http://purl.obolibrary.org/obo/MP_0010849 abnormal effector memory CD8-positive, alpha-beta T cell number http://purl.obolibrary.org/obo/MP_0012774 abnormal CD8-positive, alpha-beta memory T cell number any structural anomaly of a CD8-positive, alpha beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative http://purl.obolibrary.org/obo/MP_0010850 increased effector memory CD8-positive, alpha-beta T cell number http://purl.obolibrary.org/obo/MP_0010849 abnormal effector memory CD8-positive, alpha-beta T cell number increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative http://purl.obolibrary.org/obo/MP_0010851 decreased effector memory CD8-positive, alpha-beta T cell number http://purl.obolibrary.org/obo/MP_0010849 abnormal effector memory CD8-positive, alpha-beta T cell number reduced number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative http://purl.obolibrary.org/obo/MP_0010852 absent epidermal lamellar bodies http://purl.obolibrary.org/obo/MP_0009608 abnormal epidermal lamellar body morphology absence of a membrane-bounded organelle, specialized for the storage and secretion various substances (glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae http://purl.obolibrary.org/obo/MP_0010854 lung situs inversus http://purl.obolibrary.org/obo/MP_0010853 abnormal lung position or orientation anomaly in the asymmetry of the lung such that lung lobes on both the left and right side have the morphology normally seen on the opposite side of the body http://purl.obolibrary.org/obo/MP_0010855 pulmonary hyperemia http://purl.obolibrary.org/obo/MP_0002295 abnormal pulmonary circulation increased amount of blood flow into the lungs http://purl.obolibrary.org/obo/MP_0010856 dilated respiratory conducting tubes http://purl.obolibrary.org/obo/MP_0004391 abnormal respiratory conducting tube morphology expansion or widening of the lumens of the tubes of the respiratory system that allow passage of air from the trachea to the alveoli of the lungs http://purl.obolibrary.org/obo/MP_0010857 pulmonary necrosis http://purl.obolibrary.org/obo/MP_0001175 abnormal lung morphology morphological changes resulting from pathological death of pulmonary tissue; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0010858 pulmonary epithelial necrosis http://purl.obolibrary.org/obo/MP_0010857 pulmonary necrosis morphological changes resulting from pathological death of pulmonary epithelial tissue; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0010859 abnormal anterior commissure pars anterior morphology http://purl.obolibrary.org/obo/MP_0008225 abnormal anterior commissure morphology any structural anomaly of the small horseshoe-shaped anterior part of the anterior commissure which pass into the two olfactory bulbs http://purl.obolibrary.org/obo/MP_0010860 abnormal anterior commissure pars posterior morphology http://purl.obolibrary.org/obo/MP_0008225 abnormal anterior commissure morphology any structural anomaly of the large posterior part of the anterior commissure which connects the right and left temporal lobes http://purl.obolibrary.org/obo/MP_0010861 increased respiratory mucosa goblet cell number http://purl.obolibrary.org/obo/MP_0002281 abnormal respiratory mucosa goblet cell morphology greater number of the cells of the respiratory epithelial lining that produce and secrete mucins http://purl.obolibrary.org/obo/MP_0010862 decreased respiratory mucosa goblet cell number http://purl.obolibrary.org/obo/MP_0002281 abnormal respiratory mucosa goblet cell morphology reduced number of the cells of the respiratory epithelial lining that produce and secrete mucins http://purl.obolibrary.org/obo/MP_0010863 absent respiratory mucosa goblet cells http://purl.obolibrary.org/obo/MP_0010862 decreased respiratory mucosa goblet cell number absence of the cells of the respiratory epithelial lining that produce and secrete mucins http://purl.obolibrary.org/obo/MP_0010864 abnormal enamel knot morphology http://purl.obolibrary.org/obo/MP_0010747 abnormal enamel organ morphology any structural anomaly of a transient cluster of cells in the central part of the dental epithelium facing the dental mesenchyme, which acts as an organizing center, providing positional information for tooth morphogenesis and regulating the growth of tooth cusps http://purl.obolibrary.org/obo/MP_0010867 abnormal bone trabecula morphology http://purl.obolibrary.org/obo/MP_0000130 abnormal trabecular bone morphology any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force http://purl.obolibrary.org/obo/MP_0010868 increased bone trabecula number http://purl.obolibrary.org/obo/MP_0010867 abnormal bone trabecula morphology increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force http://purl.obolibrary.org/obo/MP_0010869 decreased bone trabecula number http://purl.obolibrary.org/obo/MP_0010867 abnormal bone trabecula morphology decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force http://purl.obolibrary.org/obo/MP_0010870 absent bone trabeculae http://purl.obolibrary.org/obo/MP_0010867 abnormal bone trabecula morphology absence of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force http://purl.obolibrary.org/obo/MP_0010871 abnormal trabecular bone mass http://purl.obolibrary.org/obo/MP_0000130 abnormal trabecular bone morphology anomaly in the total amount of trabecular bone tissue contained in the skeleton http://purl.obolibrary.org/obo/MP_0010872 increased trabecular bone mass http://purl.obolibrary.org/obo/MP_0010871 abnormal trabecular bone mass greater total amount of trabecular bone tissue contained in the skeleton http://purl.obolibrary.org/obo/MP_0010873 decreased trabecular bone mass http://purl.obolibrary.org/obo/MP_0010871 abnormal trabecular bone mass reduced total amount of trabecular bone tissue contained in the skeleton http://purl.obolibrary.org/obo/MP_0010874 abnormal bone volume http://purl.obolibrary.org/obo/MP_0003795 abnormal bone structure any anomaly in the amount of space occupied by bone tissue in the skeleton http://purl.obolibrary.org/obo/MP_0010875 increased bone volume http://purl.obolibrary.org/obo/MP_0010874 abnormal bone volume increased amount of space occupied by bone tissue in the skeleton http://purl.obolibrary.org/obo/MP_0010876 decreased bone volume http://purl.obolibrary.org/obo/MP_0010874 abnormal bone volume reduced amount of space occupied by bone tissue in the skeleton http://purl.obolibrary.org/obo/MP_0010877 abnormal trabecular bone volume http://purl.obolibrary.org/obo/MP_0010874 abnormal bone volume any anomaly in the amount of space occupied by trabecular bone tissue in the skeleton http://purl.obolibrary.org/obo/MP_0010878 increased trabecular bone volume http://purl.obolibrary.org/obo/MP_0010877 abnormal trabecular bone volume increase in the amount of space occupied by trabecular bone tissue in the skeleton http://purl.obolibrary.org/obo/MP_0010879 decreased trabecular bone volume http://purl.obolibrary.org/obo/MP_0010877 abnormal trabecular bone volume decrease in the amount of space occupied by trabecular bone tissue in the skeleton http://purl.obolibrary.org/obo/MP_0010880 small esophagus http://purl.obolibrary.org/obo/MP_0000467 abnormal esophagus morphology reduced size of the part of the digestive canal through which food passes from the pharynx to the stomach http://purl.obolibrary.org/obo/MP_0010881 esophagus hypoplasia http://purl.obolibrary.org/obo/MP_0010880 small esophagus underdevelopment or decreased size of the esophagus, usually due a reduced number of cells http://purl.obolibrary.org/obo/MP_0010882 trachea hypoplasia http://purl.obolibrary.org/obo/MP_0004549 small trachea underdevelopment or reduced size of the trachea, usually due a reduced number of cells http://purl.obolibrary.org/obo/MP_0010883 trachea stenosis http://purl.obolibrary.org/obo/MP_0002282 abnormal trachea morphology abnormal narrowing or constriction of the trachea http://purl.obolibrary.org/obo/MP_0010884 esophagus stenosis http://purl.obolibrary.org/obo/MP_0000467 abnormal esophagus morphology abnormal narrowing or constriction of the esophagus http://purl.obolibrary.org/obo/MP_0010885 absent trachea http://purl.obolibrary.org/obo/MP_0002282 abnormal trachea morphology absence of the tube descending from the larynx and branching into the right and left main bronchi http://purl.obolibrary.org/obo/MP_0010886 absent minor salivary glands http://purl.obolibrary.org/obo/MP_0003791 abnormal minor salivary gland morphology all of the smaller, largely mucus-secreting, exocrine glands of the oral cavity, consisting of the labial, buccal, molar, lingual, and palatine glands are absent http://purl.obolibrary.org/obo/MP_0010887 pale lung http://purl.obolibrary.org/obo/MP_0001175 abnormal lung morphology lung lacking normal reddish coloration; often occurs with a bloodless or reduced vasculature condition http://purl.obolibrary.org/obo/MP_0010889 small alveolar lamellar bodies http://purl.obolibrary.org/obo/MP_0010813 abnormal alveolar lamellar body morphology decreased size of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant http://purl.obolibrary.org/obo/MP_0010890 decreased alveolar lamellar body number http://purl.obolibrary.org/obo/MP_0010813 abnormal alveolar lamellar body morphology reduced number of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant http://purl.obolibrary.org/obo/MP_0010891 increased alveolar lamellar body number http://purl.obolibrary.org/obo/MP_0010813 abnormal alveolar lamellar body morphology greater number of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant http://purl.obolibrary.org/obo/MP_0010892 increased oligodendrocyte progenitor number http://purl.obolibrary.org/obo/MP_0000913 abnormal brain development greater number of cells that differentiate into a type of glial cell in the central nervous system http://purl.obolibrary.org/obo/MP_0010893 abnormal posterior commissure morphology http://purl.obolibrary.org/obo/MP_0002199 abnormal brain commissure morphology any structural anomaly of the band of nerve fiber tracts that span the longitudinal fissure beneath the habenula of the pineal body and over the cerebral aqueduct, interconnecting the left and right pretectal regions and some midbrain nuclei http://purl.obolibrary.org/obo/MP_0010894 pulmonary alveolar edema http://purl.obolibrary.org/obo/MP_0003828 pulmonary edema an effusion of serous fluid into the pulmonary alveoli; usually caused by the movement of blood components through the pulmonary capillary walls as a result of a change in osmotic pressure, an increased permeability of the walls, or related factors http://purl.obolibrary.org/obo/MP_0010895 increased lung compliance http://purl.obolibrary.org/obo/MP_0002333 abnormal lung compliance increased ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure http://purl.obolibrary.org/obo/MP_0010896 decreased lung compliance http://purl.obolibrary.org/obo/MP_0002333 abnormal lung compliance reduced ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure http://purl.obolibrary.org/obo/MP_0010897 abnormal bronchiole epithelium morphology http://purl.obolibrary.org/obo/MP_0006382 abnormal lung epithelium morphology any structural anomaly of the epithelial layer of the bronchioles http://purl.obolibrary.org/obo/MP_0010899 abnormal pulmonary alveolar system morphology http://purl.obolibrary.org/obo/MP_0001175 abnormal lung morphology any structural anomaly of the portion of the lung comprised of the pulmonary acinus and the alveolar parenchyma http://purl.obolibrary.org/obo/MP_0010902 abnormal pulmonary alveolar sac morphology http://purl.obolibrary.org/obo/MP_0010911 abnormal pulmonary acinus morphology any structural anomaly of the small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters http://purl.obolibrary.org/obo/MP_0010904 abnormal alveolar pore morphology http://purl.obolibrary.org/obo/MP_0010900 abnormal pulmonary interalveolar septum morphology any structural anomaly of the openings in the alveolar septum that permit air flow between adjacent alveoli http://purl.obolibrary.org/obo/MP_0010905 absent alveolar pores http://purl.obolibrary.org/obo/MP_0010904 abnormal alveolar pore morphology absence of the openings in the alveolar septum that permit air flow between adjacent alveoli http://purl.obolibrary.org/obo/MP_0010906 abnormal lung bud morphology http://purl.obolibrary.org/obo/MP_0001176 abnormal lung development any structural anomaly of the primary outgrowth of the embryonic trachea i.e. blunt end of the respiratory diverticulum which grows ventrally out of the proximal end of the foregut, then extends caudally and divides into two, forming the anlage of a primary bronchus and all its branches http://purl.obolibrary.org/obo/MP_0010907 absent lung buds http://purl.obolibrary.org/obo/MP_0010906 abnormal lung bud morphology absence of the blunt end of the respiratory diverticulum which normally grows ventrally out of the proximal end of the foregut, then extends caudally and divides into two, forming the origins of the bronchial tree http://purl.obolibrary.org/obo/MP_0010908 dilated pulmonary alveolar ducts http://purl.obolibrary.org/obo/MP_0002271 abnormal pulmonary alveolar duct morphology expansion or widening of the lumens of the respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli http://purl.obolibrary.org/obo/MP_0010909 pulmonary alveolar hemorrhage http://purl.obolibrary.org/obo/MP_0001182 lung hemorrhage bleeding into the small sac-like dilations of the distal airspace of the lung http://purl.obolibrary.org/obo/MP_0010910 bronchiolar epithelial hyperplasia http://purl.obolibrary.org/obo/MP_0010897 abnormal bronchiole epithelium morphology increased size, often due to increased epithelial cell number, of the epithelial layer of the bronchioles http://purl.obolibrary.org/obo/MP_0010912 herniated liver http://purl.obolibrary.org/obo/MP_0000598 abnormal liver morphology protrusion of any portion of the liver from its normal anatomical position http://purl.obolibrary.org/obo/MP_0010913 abnormal neuroendocrine cell morphology http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology any structural anomaly of a neuron that has the specialized function to produce and secrete hormones, contains neruosecretory granules, and that constitutes, in whole or in part, an endocrine organ or system http://purl.obolibrary.org/obo/MP_0010914 abnormal solitary pulmonary neuroendocrine cell morphology http://purl.obolibrary.org/obo/MP_0010913 abnormal neuroendocrine cell morphology any structural anomaly of the specialized non-ciliated, round- to oval-shaped epithelial cells found as solitary cells in the nasal respiratory epithelium and the mucosa of the larynx, trachea and bronchi up to the terminal bronchioles; PNECs are the first cell type to differentiate during early fetal lung development, produce amine (e.g. serotonin, 5-HT) and peptides (e.g. bombesin, calcitonin) with growth factor-like properties, and appear to be involved in processes ranging from lung development and respiratory physiology to repair, disease and carcinogenesis http://purl.obolibrary.org/obo/MP_0010915 increased solitary pulmonary neuroendocrine cell number http://purl.obolibrary.org/obo/MP_0010914 abnormal solitary pulmonary neuroendocrine cell morphology increased number of the specialized non-ciliated, round- to oval-shaped epithelial cells found as solitary cells in the nasal respiratory epithelium and the mucosa of the larynx, trachea and bronchi up to the terminal bronchioles; PNECs are the first cell type to differentiate during early fetal lung development, produce amine (e.g. serotonin, 5-HT) and peptides (e.g. bombesin, calcitonin) with growth factor-like properties, and appear to be involved in processes ranging from lung development and respiratory physiology to repair, disease and carcinogenesis http://purl.obolibrary.org/obo/MP_0010916 decreased solitary pulmonary neuroendocrine cell number http://purl.obolibrary.org/obo/MP_0010914 abnormal solitary pulmonary neuroendocrine cell morphology decreased number of the specialized non-ciliated, round- to oval-shaped epithelial cells found as solitary cells in the nasal respiratory epithelium and the mucosa of the larynx, trachea and bronchi up to the terminal bronchioles; PNECs are the first cell type to differentiate during early fetal lung development, produce amine (e.g. serotonin, 5-HT) and peptides (e.g. bombesin, calcitonin) with growth factor-like properties, and appear to be involved in processes ranging from lung development and respiratory physiology to repair, disease and carcinogenesis http://purl.obolibrary.org/obo/MP_0010917 absent solitary pulmonary neuroendocrine cells http://purl.obolibrary.org/obo/MP_0010914 abnormal solitary pulmonary neuroendocrine cell morphology absence of the specialized non-ciliated, round- to oval-shaped epithelial cells found as solitary cells in the nasal respiratory epithelium and the mucosa of the larynx, trachea and bronchi up to the terminal bronchioles; PNECs are the first cell type to differentiate during early fetal lung development, produce amine (e.g. serotonin, 5-HT) and peptides (e.g. bombesin, calcitonin) with growth factor-like properties, and appear to be involved in processes ranging from lung development and respiratory physiology to repair, disease and carcinogenesis http://purl.obolibrary.org/obo/MP_0010918 abnormal pulmonary neuroendocrine body morphology http://purl.obolibrary.org/obo/MP_0006382 abnormal lung epithelium morphology any structural anomaly of the corpuscular, organoid structures composed of PNECs, found as distinctive innervated clusters only within intrapulmonary airways, where they appear concentrated at airway branch points; NEBs reach from the basement membrane to the airway lumen and are thought to function as oxygen sensors http://purl.obolibrary.org/obo/MP_0010919 increased number of pulmonary neuroendocrine bodies http://purl.obolibrary.org/obo/MP_0010918 abnormal pulmonary neuroendocrine body morphology greater number of the corpuscular, organoid structures composed of PNECs, found as distinctive innervated clusters only within intrapulmonary airways, where they appear concentrated at airway branch points; NEBs reach from the basement membrane to the airway lumen and are thought to function as oxygen sensors http://purl.obolibrary.org/obo/MP_0010920 decreased number of pulmonary neuroendocrine bodies http://purl.obolibrary.org/obo/MP_0010918 abnormal pulmonary neuroendocrine body morphology reduction in the number of the corpuscular, organoid structures composed of PNECs, found as distinctive innervated clusters only within intrapulmonary airways, where they appear concentrated at airway branch points; NEBs reach from the basement membrane to the airway lumen and are thought to function as oxygen sensors http://purl.obolibrary.org/obo/MP_0010921 absent pulmonary neuroendocrine bodies http://purl.obolibrary.org/obo/MP_0010918 abnormal pulmonary neuroendocrine body morphology absence of the corpuscular, organoid structures composed of PNECs, found as distinctive innervated clusters only within intrapulmonary airways, where they appear concentrated at airway branch points; NEBs reach from the basement membrane to the airway lumen and are thought to function as oxygen sensors http://purl.obolibrary.org/obo/MP_0010922 alveolitis http://purl.obolibrary.org/obo/MP_0001861 lung inflammation inflammation of the small sac-like dilations of the distal airspace of the lung; acute pulmonary alveolitis involves exudate into the pulmonary alveoli and impaired gas exchange http://purl.obolibrary.org/obo/MP_0010923 calcified pulmonary alveolus http://purl.obolibrary.org/obo/MP_0002270 abnormal pulmonary alveolus morphology pathologic deposition of calcium salts in the pulmonary alveoli http://purl.obolibrary.org/obo/MP_0010924 abnormal osteoid morphology http://purl.obolibrary.org/obo/MP_0002113 abnormal skeleton development any structural anomaly of newly formed organic bone matrix secreted by osteoblasts, that exists prior to calcification; it is comprised mainly of type I collagen fibers, chondroitin sulfate and osteocalcin http://purl.obolibrary.org/obo/MP_0010925 abnormal osteoid volume http://purl.obolibrary.org/obo/MP_0010924 abnormal osteoid morphology any anomaly in the amount of space occupied by newly formed organic bone matrix secreted by osteoblasts http://purl.obolibrary.org/obo/MP_0010926 increased osteoid volume http://purl.obolibrary.org/obo/MP_0010925 abnormal osteoid volume increase in the amount of space occupied by newly formed organic bone matrix secreted by osteoblasts http://purl.obolibrary.org/obo/MP_0010927 decreased osteoid volume http://purl.obolibrary.org/obo/MP_0010925 abnormal osteoid volume reduction in the amount of space occupied by newly formed organic bone matrix secreted by osteoblasts http://purl.obolibrary.org/obo/MP_0010928 abnormal osteoid thickness http://purl.obolibrary.org/obo/MP_0010924 abnormal osteoid morphology anomaly in the width of the layer of newly formed organic bone matrix secreted by osteoblasts http://purl.obolibrary.org/obo/MP_0010929 increased osteoid thickness http://purl.obolibrary.org/obo/MP_0010928 abnormal osteoid thickness increase in the width of the layer of newly formed organic bone matrix secreted by osteoblasts http://purl.obolibrary.org/obo/MP_0010930 decreased osteoid thickness http://purl.obolibrary.org/obo/MP_0010928 abnormal osteoid thickness reduction in the width of the layer of newly formed organic bone matrix secreted by osteoblasts http://purl.obolibrary.org/obo/MP_0010931 abnormal trabecular bone connectivity density http://purl.obolibrary.org/obo/MP_0000130 abnormal trabecular bone morphology any anomaly in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures http://purl.obolibrary.org/obo/MP_0010932 increased trabecular bone connectivity density http://purl.obolibrary.org/obo/MP_0010931 abnormal trabecular bone connectivity density increase in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures http://purl.obolibrary.org/obo/MP_0010933 decreased trabecular bone connectivity density http://purl.obolibrary.org/obo/MP_0010931 abnormal trabecular bone connectivity density reduction in the extent of attachments between trabeculae; it may be expressed in ratios of nodes to free ends, trabecular bone pattern factor, and related measures http://purl.obolibrary.org/obo/MP_0010934 increased subcutaneous adipose tissue amount http://purl.obolibrary.org/obo/MP_0011156 abnormal hypodermis fat layer morphology increase in amount of adipose tissue beneath the skin http://purl.obolibrary.org/obo/MP_0010935 increased airway resistance http://purl.obolibrary.org/obo/MP_0002328 abnormal airway resistance greater opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow http://purl.obolibrary.org/obo/MP_0010936 decreased airway resistance http://purl.obolibrary.org/obo/MP_0002328 abnormal airway resistance reduced opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow http://purl.obolibrary.org/obo/MP_0010937 increased total lung capacity http://purl.obolibrary.org/obo/MP_0002304 abnormal total lung capacity greater volume of air contained in the lungs at the end of maximal inspiration http://purl.obolibrary.org/obo/MP_0010938 decreased total lung capacity http://purl.obolibrary.org/obo/MP_0002304 abnormal total lung capacity reduced volume of air contained in the lungs at the end of maximal inspiration http://purl.obolibrary.org/obo/MP_0010939 abnormal mandibular prominence morphology http://purl.obolibrary.org/obo/MP_0003935 abnormal craniofacial development any structural anomaly of the paired ventral prominences formed by bifurcation of the first pharyngeal arches in the embryo; the two prominences unite ventrally and fuse to form the mandible and lower lip http://purl.obolibrary.org/obo/MP_0010940 abnormal maxillary prominence morphology http://purl.obolibrary.org/obo/MP_0003935 abnormal craniofacial development any structural anomaly of the paired dorsal prominences formed by bifurcation of the first pharyngeal arches in the embryo that unite with the ipsilateral medial nasal process to form the upper jaw http://purl.obolibrary.org/obo/MP_0010941 abnormal foramen magnum morphology http://purl.obolibrary.org/obo/MP_0005269 abnormal occipital bone morphology any structural anomaly of the large orifice in the occipital bone through which the spinal cord passes to the cranial cavity and becomes continuous with the medulla oblongata http://purl.obolibrary.org/obo/MP_0010943 abnormal bronchus epithelium morphology http://purl.obolibrary.org/obo/MP_0006382 abnormal lung epithelium morphology any structural anomaly of the epithelial layer of the bronchi http://purl.obolibrary.org/obo/MP_0010944 respiratory epithelium hypertrophy http://purl.obolibrary.org/obo/MP_0010942 abnormal respiratory epithelium morphology increase in the bulk size of the pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi; may be due to cell enlargement or excessive production/accumulation of mucus material http://purl.obolibrary.org/obo/MP_0010945 lung epithelium hyperplasia http://purl.obolibrary.org/obo/MP_0010942 abnormal respiratory epithelium morphology overdevelopment or increased size, usually due an increased number of cells in the epithelial layer of the lung http://purl.obolibrary.org/obo/MP_0010946 hyperpnea http://purl.obolibrary.org/obo/MP_0001951 abnormal breathing pattern breathing that is deeper and more rapid than normal http://purl.obolibrary.org/obo/MP_0010947 abnormal single-strand DNA break repair http://purl.obolibrary.org/obo/MP_0008058 abnormal DNA repair anomaly in the process of repair of single strand breaks in DNA; repair of such breaks is mediated by the same enzyme systems as are used in base excision repair http://purl.obolibrary.org/obo/MP_0010948 abnormal double-strand DNA break repair http://purl.obolibrary.org/obo/MP_0008058 abnormal DNA repair any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix http://purl.obolibrary.org/obo/MP_0010949 decreased Clara cell number http://purl.obolibrary.org/obo/MP_0010809 abnormal Clara cell morphology reduced number of the rounded, club-shaped, nonciliated cells found between ciliated cells in bronchiolar epithelium http://purl.obolibrary.org/obo/MP_0010950 abnormal lung hysteresivity http://purl.obolibrary.org/obo/MP_0002133 abnormal respiratory system physiology anomaly in the lung tissue property defined as the ratio of dissipated energy to stored energy over a respiratory cycle; it can be measured as the area enclosed by a pressure-volume loop of the lung, and is dependent on composition and microstructure of the tissue components such as the elastic connective tissue http://purl.obolibrary.org/obo/MP_0010951 abnormal lipid oxidation http://purl.obolibrary.org/obo/MP_0005621 abnormal cell physiology anomaly in the process of removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen http://purl.obolibrary.org/obo/MP_0010952 abnormal fatty acid beta-oxidation http://purl.obolibrary.org/obo/MP_0010953 abnormal fatty acid oxidation anomaly in the process that results in the complete oxidation of a long-chain fatty acid, beginning with the addition of coenzyme A to a fatty acid, with successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively) http://purl.obolibrary.org/obo/MP_0010953 abnormal fatty acid oxidation http://purl.obolibrary.org/obo/MP_0010951 abnormal lipid oxidation anomaly in the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. http://purl.obolibrary.org/obo/MP_0010954 abnormal cellular respiration http://purl.obolibrary.org/obo/MP_0005621 abnormal cell physiology anomaly in the enzymatic release of energy from organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration) http://purl.obolibrary.org/obo/MP_0010955 abnormal respiratory electron transport chain http://purl.obolibrary.org/obo/MP_0010954 abnormal cellular respiration anomaly in the process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient http://purl.obolibrary.org/obo/MP_0010956 abnormal mitochondrial ATP synthesis coupled electron transport http://purl.obolibrary.org/obo/MP_0010959 abnormal oxidative phosphorylation anomaly in the transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane and mediated by multisubunit enzyme complexes known as complex I-IV http://purl.obolibrary.org/obo/MP_0010957 abnormal aerobic respiration http://purl.obolibrary.org/obo/MP_0010954 abnormal cellular respiration any anomaly in the process of enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor http://purl.obolibrary.org/obo/MP_0010958 abnormal tricarboxylic acid cycle http://purl.obolibrary.org/obo/MP_0010957 abnormal aerobic respiration any anomaly in the universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes; the acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle http://purl.obolibrary.org/obo/MP_0010959 abnormal oxidative phosphorylation http://purl.obolibrary.org/obo/MP_0006036 abnormal mitochondrial physiology any anomaly in the process of phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain; oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis http://purl.obolibrary.org/obo/MP_0010960 abnormal compact bone mass http://purl.obolibrary.org/obo/MP_0003797 abnormal compact bone morphology anomaly in the total amount of compact bone tissue contained in the skeleton http://purl.obolibrary.org/obo/MP_0010961 increased compact bone mass http://purl.obolibrary.org/obo/MP_0010960 abnormal compact bone mass greater than normal total amount of compact bone tissue contained in the skeleton http://purl.obolibrary.org/obo/MP_0010962 decreased compact bone mass http://purl.obolibrary.org/obo/MP_0010960 abnormal compact bone mass less than normal total amount of compact bone tissue contained in the skeleton http://purl.obolibrary.org/obo/MP_0010963 abnormal compact bone volume http://purl.obolibrary.org/obo/MP_0010874 abnormal bone volume any anomaly in the amount of space occupied by compact bone tissue in the skeleton http://purl.obolibrary.org/obo/MP_0010964 increased compact bone volume http://purl.obolibrary.org/obo/MP_0010963 abnormal compact bone volume greater than normal amount of space occupied by compact bone tissue in the skeleton http://purl.obolibrary.org/obo/MP_0010965 decreased compact bone volume http://purl.obolibrary.org/obo/MP_0010963 abnormal compact bone volume less than normal amount of space occupied by compact bone tissue in the skeleton http://purl.obolibrary.org/obo/MP_0010966 abnormal compact bone area http://purl.obolibrary.org/obo/MP_0003797 abnormal compact bone morphology anomaly in the total amount of cross-sectional area of compact bone tissue http://purl.obolibrary.org/obo/MP_0010967 increased compact bone area http://purl.obolibrary.org/obo/MP_0010966 abnormal compact bone area increase in the total amount of cross-sectional area of compact bone tissue http://purl.obolibrary.org/obo/MP_0010968 decreased compact bone area http://purl.obolibrary.org/obo/MP_0010966 abnormal compact bone area reduction in the total amount of cross-sectional area of compact bone tissue http://purl.obolibrary.org/obo/MP_0010969 absent compact bone http://purl.obolibrary.org/obo/MP_0003797 abnormal compact bone morphology absence of the outer layers of solid, hard bone that covers spongy bone http://purl.obolibrary.org/obo/MP_0010970 abnormal compact bone lamellar structure http://purl.obolibrary.org/obo/MP_0003797 abnormal compact bone morphology any structural anomaly of the concentric layers of calcified matrix interspersed with osteocytes lodged in lacunae between the lamellae that comprise the cylindrical osteons http://purl.obolibrary.org/obo/MP_0010971 abnormal periosteum morphology http://purl.obolibrary.org/obo/MP_0003795 abnormal bone structure any structural anomaly of the thick fibrous membrane that closely invests the entire surface of a bone except the articular cartilage at synovial joints http://purl.obolibrary.org/obo/MP_0010972 absent periosteum http://purl.obolibrary.org/obo/MP_0010971 abnormal periosteum morphology absence of the thick fibrous membrane that closely invests the entire surface of a bone except the articular cartilage at synovial joints http://purl.obolibrary.org/obo/MP_0010973 increased periosteum thickness http://purl.obolibrary.org/obo/MP_0010971 abnormal periosteum morphology increased width of the thick fibrous membrane that closely invests the entire surface of a bone except the articular cartilage at synovial joints http://purl.obolibrary.org/obo/MP_0010974 decreased periosteum thickness http://purl.obolibrary.org/obo/MP_0010971 abnormal periosteum morphology decreased width of the thick fibrous membrane that closely invests the entire surface of a bone except the articular cartilage at synovial joints http://purl.obolibrary.org/obo/MP_0010975 abnormal lung lobe morphology http://purl.obolibrary.org/obo/MP_0001175 abnormal lung morphology any structural anomaly of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue) http://purl.obolibrary.org/obo/MP_0010976 small lung lobe http://purl.obolibrary.org/obo/MP_0010975 abnormal lung lobe morphology reduced size of any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung, where each lobe receives air from its own secondary bronchus and is separated from it neighbors by one or more fissures (walls of connective tissue) http://purl.obolibrary.org/obo/MP_0010977 fused right lung lobes http://purl.obolibrary.org/obo/MP_0010975 abnormal lung lobe morphology complete or partial fusion of the right lung lobes, indicative of defective lobar septation during embryonic lung development http://purl.obolibrary.org/obo/MP_0010978 absent ureteric bud http://purl.obolibrary.org/obo/MP_0006032 abnormal ureteric bud morphology absence of the epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme http://purl.obolibrary.org/obo/MP_0010979 small ureteric bud http://purl.obolibrary.org/obo/MP_0006032 abnormal ureteric bud morphology reduced size of the epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme http://purl.obolibrary.org/obo/MP_0010980 ectopic ureteric bud http://purl.obolibrary.org/obo/MP_0006032 abnormal ureteric bud morphology ureteric bud(s) are not located in the normal or expected position http://purl.obolibrary.org/obo/MP_0010981 abnormal branching involved in ureteric bud morphogenesis http://purl.obolibrary.org/obo/MP_0006032 abnormal ureteric bud morphology anomaly in the process in which the branching structure of the ureteric bud is generated and organized http://purl.obolibrary.org/obo/MP_0010982 abnormal ureteric bud elongation http://purl.obolibrary.org/obo/MP_0006032 abnormal ureteric bud morphology any anomaly in the process in which a ureteric bud grows along its axis http://purl.obolibrary.org/obo/MP_0010983 abnormal ureteric bud invasion http://purl.obolibrary.org/obo/MP_0010982 abnormal ureteric bud elongation any anomaly in the process in which the ureteric bud grows into the metanephric mesenchyme, and contributes to the formation of the metanephros http://purl.obolibrary.org/obo/MP_0010984 abnormal metanephric mesenchyme morphology http://purl.obolibrary.org/obo/MP_0010985 abnormal kidney mesenchyme morphology any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing metanephros; interactions between the ureteric bud and the metanephric mesenchyme leads to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue http://purl.obolibrary.org/obo/MP_0010985 abnormal kidney mesenchyme morphology http://purl.obolibrary.org/obo/MP_0000527 abnormal kidney development any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing kidney http://purl.obolibrary.org/obo/MP_0010986 abnormal mesonephric mesenchyme morphology http://purl.obolibrary.org/obo/MP_0010985 abnormal kidney mesenchyme morphology any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing mesonephros http://purl.obolibrary.org/obo/MP_0010987 abnormal nephrogenic mesenchyme morphogenesis http://purl.obolibrary.org/obo/MP_0010985 abnormal kidney mesenchyme morphology any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing nephron http://purl.obolibrary.org/obo/MP_0010988 abnormal bronchial cartilage morphology http://purl.obolibrary.org/obo/MP_0002264 abnormal bronchus morphology any structural anomaly of the hyaline cartilaginous structures that support the bronchi, present as irregular rings in the larger bronchi (and not as regular as in the trachea), and as small plates and islands in the smaller bronchi; as the branching continues through the bronchial tree, the amount of hyaline cartilage in the walls decreases until it is absent in the smallest bronchioles http://purl.obolibrary.org/obo/MP_0010989 fused bronchial cartilage rings http://purl.obolibrary.org/obo/MP_0010988 abnormal bronchial cartilage morphology fusion of the hyaline cartilaginous structures that support the bronchi http://purl.obolibrary.org/obo/MP_0010992 increased surfactant secretion http://purl.obolibrary.org/obo/MP_0004780 abnormal surfactant secretion greater production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli http://purl.obolibrary.org/obo/MP_0010993 decreased surfactant secretion http://purl.obolibrary.org/obo/MP_0004780 abnormal surfactant secretion decreased production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli http://purl.obolibrary.org/obo/MP_0010994 aerophagia http://purl.obolibrary.org/obo/MP_0002133 abnormal respiratory system physiology excessive swallowing of air or gas http://purl.obolibrary.org/obo/MP_0010995 abnormal lung alveolus development http://purl.obolibrary.org/obo/MP_0001176 abnormal lung development anomaly in the formation of the sacs for holding air in the lungs, which are formed by the terminal dilation of air passageways http://purl.obolibrary.org/obo/MP_0010996 increased aorta wall thickness http://purl.obolibrary.org/obo/MP_0009866 abnormal aorta wall morphology increased depth of the part of the aorta that encloses the luminal space http://purl.obolibrary.org/obo/MP_0010997 decreased aorta wall thickness http://purl.obolibrary.org/obo/MP_0009866 abnormal aorta wall morphology decreased depth of the part of the aorta that encloses the luminal space http://purl.obolibrary.org/obo/MP_0010998 pulmonary alveolar proteinosis http://purl.obolibrary.org/obo/MP_0010999 proteinosis abnormal intra-alveolar accumulation of an amorphous, largely cell-free, surfactant-like lipoproteinaceous material that is not easily cleared from the lungs http://purl.obolibrary.org/obo/MP_0010999 proteinosis http://purl.obolibrary.org/obo/MP_0008469 abnormal protein level disordered protein formation and distribution, especially manifested by the accumulation of excess or abnormal proteins in tissues http://purl.obolibrary.org/obo/MP_0011001 absence of AMPA-mediated synaptic currents http://purl.obolibrary.org/obo/MP_0002885 abnormal AMPA-mediated synaptic currents absence of a measured amplitude, current density or response to stimulation of NMDA receptors http://purl.obolibrary.org/obo/MP_0011002 enhanced AMPA-mediated synaptic currents http://purl.obolibrary.org/obo/MP_0002885 abnormal AMPA-mediated synaptic currents increase in the measured amplitude, current density or duration of response to stimulation of AMPA receptors http://purl.obolibrary.org/obo/MP_0011003 reduced AMPA-mediated synaptic currents http://purl.obolibrary.org/obo/MP_0002885 abnormal AMPA-mediated synaptic currents reduction in the measured amplitude, current density or duration of response to stimulation of AMPA receptors http://purl.obolibrary.org/obo/MP_0011004 abnormal epidermal stem cell morphology http://purl.obolibrary.org/obo/MP_0003941 abnormal skin development any structural anomaly of a somatic stem cell that is part of the epidermis http://purl.obolibrary.org/obo/MP_0011005 abnormal epidermal stem cell physiology http://purl.obolibrary.org/obo/MP_0005501 abnormal skin physiology any functional anomaly of a somatic stem cell that is part of the epidermis http://purl.obolibrary.org/obo/MP_0011006 abnormal epidermal stem cell proliferation http://purl.obolibrary.org/obo/MP_0011005 abnormal epidermal stem cell physiology anomaly in the ability of the a a somatic stem cell population that is part of the epidermis to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0011007 abnormal epidermal stem cell apoptosis http://purl.obolibrary.org/obo/MP_0011005 abnormal epidermal stem cell physiology change in the timing or the number of somatic stem cells that are part of the epidermis, undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0011008 abnormal circulating glutamate dehydrogenase level http://purl.obolibrary.org/obo/MP_0001570 abnormal circulating enzyme level any anomaly in the concentration in the blood of the enzymes which catalyze the reaction of L-glutamate, water and NAD+, producing alpha-ketoglutarate, ammonia, and NADH http://purl.obolibrary.org/obo/MP_0011009 increased circulating glutamate dehydrogenase level http://purl.obolibrary.org/obo/MP_0011008 abnormal circulating glutamate dehydrogenase level increased concentration in the blood of the enzymes which catalyze the reaction of L-glutamate, water and NAD+, producing alpha-ketoglutarate, ammonia, and NADH http://purl.obolibrary.org/obo/MP_0011010 decreased circulating glutamate dehydrogenase level http://purl.obolibrary.org/obo/MP_0011008 abnormal circulating glutamate dehydrogenase level reduced concentration in the blood of the enzymes which catalyze the reaction of L-glutamate, water and NAD+, producing alpha-ketoglutarate, ammonia, and NADH http://purl.obolibrary.org/obo/MP_0011011 impaired lung lobe morphogenesis http://purl.obolibrary.org/obo/MP_0010975 abnormal lung lobe morphology failure to form any of the anatomically and functionally distinct subunits (lobes) comprising the left or right lung http://purl.obolibrary.org/obo/MP_0011012 bronchiectasis http://purl.obolibrary.org/obo/MP_0001861 lung inflammation a chronic inflammatory or degenerative condition marked by permanent dilatation (widening) of one or more bronchi and loss of elasticity of the bronchial walls http://purl.obolibrary.org/obo/MP_0011013 bronchiolectasis http://purl.obolibrary.org/obo/MP_0011012 bronchiectasis a chronic inflammatory or degenerative condition marked by permanent dilatation (widening) of one or more bronchioles and loss of elasticity of the bronchiolar walls http://purl.obolibrary.org/obo/MP_0011014 decreased core body temperature http://purl.obolibrary.org/obo/MP_0005534 decreased body temperature reduced degree of heat natural to the internal center of a living being http://purl.obolibrary.org/obo/MP_0011015 decreased body surface temperature http://purl.obolibrary.org/obo/MP_0005534 decreased body temperature reduced degree of heat natural to skin-environment interface of a living being http://purl.obolibrary.org/obo/MP_0011016 increased core body temperature http://purl.obolibrary.org/obo/MP_0005533 increased body temperature increased degree of heat natural to the internal center of a living being http://purl.obolibrary.org/obo/MP_0011017 increased body surface temperature http://purl.obolibrary.org/obo/MP_0005533 increased body temperature increased degree of heat natural to the skin-environment interface of a living being http://purl.obolibrary.org/obo/MP_0011018 pulmonary hyaline membrane formation http://purl.obolibrary.org/obo/MP_0002133 abnormal respiratory system physiology abnormal presence of an eosinophilic hyaline (glass-like) material composed of fibrin, proteinaceous exudate and cellular debris, and lining or filling the alveoli, alveolar ducts and bronchioles; hyaline membranes block gas exchange and are usually found at autopsy in individuals that have died of respiratory distress syndrome in the neonatal stages http://purl.obolibrary.org/obo/MP_0011019 abnormal adaptive thermogenesis http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis anomaly in the regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death http://purl.obolibrary.org/obo/MP_0011020 abnormal circadian temperature homeostasis http://purl.obolibrary.org/obo/MP_0001777 abnormal body temperature homeostasis any anomaly in the process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours http://purl.obolibrary.org/obo/MP_0011021 abnormal circadian regulation of heart rate http://purl.obolibrary.org/obo/MP_0004085 abnormal heartbeat anomaly in the process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours http://purl.obolibrary.org/obo/MP_0011022 abnormal circadian regulation of systemic arterial blood pressure http://purl.obolibrary.org/obo/MP_0010697 abnormal systemic arterial blood pressure regulation any anomaly in the process in which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours http://purl.obolibrary.org/obo/MP_0011024 abnormal branching involved in lung morphogenesis http://purl.obolibrary.org/obo/MP_0001176 abnormal lung development anomaly in the process in which the branched structure of the respiratory airway tree is generated and organized http://purl.obolibrary.org/obo/MP_0011025 abnormal branching involved in trachea morphogenesis http://purl.obolibrary.org/obo/MP_0011024 abnormal branching involved in lung morphogenesis anomaly in the process in which the two main branches of the trachea is generated and organized http://purl.obolibrary.org/obo/MP_0011026 impaired branching involved in trachea morphogenesis http://purl.obolibrary.org/obo/MP_0011025 abnormal branching involved in trachea morphogenesis partial or complete failure of the process in which the two main branches of the trachea is generated and organized http://purl.obolibrary.org/obo/MP_0011027 abnormal branching involved in bronchus morphogenesis http://purl.obolibrary.org/obo/MP_0011024 abnormal branching involved in lung morphogenesis anomaly in the process in which the branched structure of the bronchus is generated and organized http://purl.obolibrary.org/obo/MP_0011028 impaired branching involved in bronchus morphogenesis http://purl.obolibrary.org/obo/MP_0011027 abnormal branching involved in bronchus morphogenesis partial or complete failure of the process in which the branched structure of the bronchus is generated and organized http://purl.obolibrary.org/obo/MP_0011029 abnormal branching involved in preterminal bronchiole morphogenesis http://purl.obolibrary.org/obo/MP_0011024 abnormal branching involved in lung morphogenesis anomaly in the process in which the branched structure of the preterminal bronchioles are generated and organized http://purl.obolibrary.org/obo/MP_0011030 impaired branching involved in preterminal bronchiole morphogenesis http://purl.obolibrary.org/obo/MP_0011029 abnormal branching involved in preterminal bronchiole morphogenesis partial or complete failure of the process in which the branched structure of the preterminal bronchioles are generated and organized http://purl.obolibrary.org/obo/MP_0011031 abnormal branching involved in terminal bronchiole morphogenesis http://purl.obolibrary.org/obo/MP_0011024 abnormal branching involved in lung morphogenesis anomaly in the process in which the branched structure of the terminal bronchioles are generated and organized http://purl.obolibrary.org/obo/MP_0011032 impaired branching involved in terminal bronchiole morphogenesis http://purl.obolibrary.org/obo/MP_0011031 abnormal branching involved in terminal bronchiole morphogenesis partial or complete failure of the process in which the branched structure of the terminal bronchioles are generated and organized http://purl.obolibrary.org/obo/MP_0011033 abnormal branching involved in respiratory bronchiole morphogenesis http://purl.obolibrary.org/obo/MP_0011024 abnormal branching involved in lung morphogenesis anomaly in the process in which the branched structure of the respiratory bronchioles are generated http://purl.obolibrary.org/obo/MP_0011034 impaired branching involved in respiratory bronchiole morphogenesis http://purl.obolibrary.org/obo/MP_0011033 abnormal branching involved in respiratory bronchiole morphogenesis partial or complete failure of the process in which the branched structure of the respiratory bronchioles are generated http://purl.obolibrary.org/obo/MP_0011035 abnormal branching involved in alveolar duct morphogenesis http://purl.obolibrary.org/obo/MP_0011024 abnormal branching involved in lung morphogenesis anomaly in the process in which the branched structure of the alveolar ducts are generated http://purl.obolibrary.org/obo/MP_0011036 impaired branching involved in alveolar duct morphogenesis http://purl.obolibrary.org/obo/MP_0011035 abnormal branching involved in alveolar duct morphogenesis partial or complete failure of the process in which the branched structure of the alveolar ducts are generated http://purl.obolibrary.org/obo/MP_0011037 abnormal branching involved in alveolar sac morphogenesis http://purl.obolibrary.org/obo/MP_0011024 abnormal branching involved in lung morphogenesis anomaly in the process in which the terminal alveolar sacs are generated http://purl.obolibrary.org/obo/MP_0011038 impaired branching involved in alveolar sac morphogenesis http://purl.obolibrary.org/obo/MP_0011037 abnormal branching involved in alveolar sac morphogenesis partial or complete failure of the process in which the terminal alveolar sacs are generated http://purl.obolibrary.org/obo/MP_0011039 abnormal vestibuloocular dark reflex http://purl.obolibrary.org/obo/MP_0004844 abnormal vestibuloocular reflex any anomaly in the nystagmus or deviation of the eyes in response to stimulation of the vestibular system when the test is run without light http://purl.obolibrary.org/obo/MP_0011040 abnormal vestibuloocular light reflex http://purl.obolibrary.org/obo/MP_0004844 abnormal vestibuloocular reflex any anomaly in the nystagmus or deviation of the eyes in response to stimulation of the vestibular system when the test is run with light http://purl.obolibrary.org/obo/MP_0011041 abnormal vertical vestibuloocular reflex http://purl.obolibrary.org/obo/MP_0004844 abnormal vestibuloocular reflex any anomaly in the nystagmus or deviation of the eyes in response to stimulation along the vertical axis of the vestibular system http://purl.obolibrary.org/obo/MP_0011042 abnormal horizontal vestibuloocular reflex http://purl.obolibrary.org/obo/MP_0004844 abnormal vestibuloocular reflex any anomaly in the nystagmus or deviation of the eyes in response to stimulation along the horizontal axis of the vestibular system http://purl.obolibrary.org/obo/MP_0011043 abnormal lung elastance http://purl.obolibrary.org/obo/MP_0002133 abnormal respiratory system physiology anomaly in the ability of the lung to recoil toward its resting dimensions upon removal of pressure without disruption, usually expressed as the unit volume of change in the lung per unit of decreased pressure change; the reciprocal of compliance http://purl.obolibrary.org/obo/MP_0011044 increased lung elastance http://purl.obolibrary.org/obo/MP_0011043 abnormal lung elastance faster ability of the lung to recoil toward its resting dimensions upon removal of pressure without disruption, usually expressed as the unit volume of change in the lung per unit of decreased pressure change; the reciprocal of compliance http://purl.obolibrary.org/obo/MP_0011045 decreased lung elastance http://purl.obolibrary.org/obo/MP_0011043 abnormal lung elastance reduced ability of the lung to recoil toward its resting dimensions upon removal of pressure without disruption, usually expressed as the unit volume of change in the lung per unit of decreased pressure change; the reciprocal of compliance http://purl.obolibrary.org/obo/MP_0011046 abnormal lung tissue damping http://purl.obolibrary.org/obo/MP_0002133 abnormal respiratory system physiology anomaly in the respiratory mechanical parameter (G) that is closely related to tissue resistance and reflects the energy dissipation in the lung tissues http://purl.obolibrary.org/obo/MP_0011047 increased lung tissue damping http://purl.obolibrary.org/obo/MP_0011046 abnormal lung tissue damping increased value of the respiratory mechanical parameter (G) that is closely related to tissue resistance and reflects the energy dissipation in the lung tissues http://purl.obolibrary.org/obo/MP_0011048 decreased lung tissue damping http://purl.obolibrary.org/obo/MP_0011046 abnormal lung tissue damping reduced value of the respiratory mechanical parameter (G) that is closely related to tissue resistance and reflects the energy dissipation in the lung tissues http://purl.obolibrary.org/obo/MP_0011049 impaired adaptive thermogenesis http://purl.obolibrary.org/obo/MP_0011019 abnormal adaptive thermogenesis inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death http://purl.obolibrary.org/obo/MP_0011050 abnormal respiratory motile cilium morphology http://purl.obolibrary.org/obo/MP_0013206 abnormal motile cilium morphology any structural anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract http://purl.obolibrary.org/obo/MP_0011051 abnormal respiratory motile cilium number http://purl.obolibrary.org/obo/MP_0011050 abnormal respiratory motile cilium morphology anomaly in the number of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract http://purl.obolibrary.org/obo/MP_0011052 increased respiratory motile cilia number http://purl.obolibrary.org/obo/MP_0011051 abnormal respiratory motile cilium number greater number of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract http://purl.obolibrary.org/obo/MP_0011053 decreased respiratory motile cilia number http://purl.obolibrary.org/obo/MP_0011051 abnormal respiratory motile cilium number reduced number of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract http://purl.obolibrary.org/obo/MP_0011054 absent respiratory motile cilia http://purl.obolibrary.org/obo/MP_0011053 decreased respiratory motile cilia number absence of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract http://purl.obolibrary.org/obo/MP_0011055 abnormal respiratory motile cilium physiology http://purl.obolibrary.org/obo/MP_0013209 abnormal motile cilium physiology any functional anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the respiratory tract; may include alterations in ciliary beating pattern or frequency http://purl.obolibrary.org/obo/MP_0011056 abnormal brain ependyma motile cilium morphology http://purl.obolibrary.org/obo/MP_0011059 abnormal ependyma motile cilium morphology any structural anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid http://purl.obolibrary.org/obo/MP_0011057 absent brain ependyma motile cilia http://purl.obolibrary.org/obo/MP_0011056 abnormal brain ependyma motile cilium morphology absence of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid http://purl.obolibrary.org/obo/MP_0011058 abnormal spinal cord motile cilium morphology http://purl.obolibrary.org/obo/MP_0011059 abnormal ependyma motile cilium morphology any structural anomaly of the tiny, motile hair-like projections from the epithelial cells that line the central canal of the spinal cord, which beat in concert and to move cerebrospinal fluid http://purl.obolibrary.org/obo/MP_0011059 abnormal ependyma motile cilium morphology http://purl.obolibrary.org/obo/MP_0013206 abnormal motile cilium morphology any structural anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain and the central canal of the spinal cord, which beat in concert and to move cerebrospinal fluid around the central nervous system http://purl.obolibrary.org/obo/MP_0011060 abnormal kinocilium morphology http://purl.obolibrary.org/obo/MP_0013205 abnormal nonmotile primary cilium morphology any structural anomaly of the nonmotile primary cilium that is found at the apical surface of auditory receptor cells http://purl.obolibrary.org/obo/MP_0011061 abnormal inner hair cell kinocilium morphology http://purl.obolibrary.org/obo/MP_0011060 abnormal kinocilium morphology any structural anomaly of the nonmotile primary cilium that is found at the apical surface of inner hair cells http://purl.obolibrary.org/obo/MP_0011062 abnormal outer hair cell kinocilium morphology http://purl.obolibrary.org/obo/MP_0011060 abnormal kinocilium morphology any structural anomaly of the nonmotile primary cilium that is found at the apical surface of outer hair cells http://purl.obolibrary.org/obo/MP_0011063 absent inner hair cell kinocilia http://purl.obolibrary.org/obo/MP_0011061 abnormal inner hair cell kinocilium morphology absence of the nonmotile primary cilium that is found at the apical surface of inner hair cells http://purl.obolibrary.org/obo/MP_0011064 abnormal vestibular hair cell kinocilium morphology http://purl.obolibrary.org/obo/MP_0011060 abnormal kinocilium morphology any structural anomaly of the nonmotile primary cilium that is found at the apical surface of vestibular hair cells http://purl.obolibrary.org/obo/MP_0011065 abnormal kidney epithelial cell primary cilium morphology http://purl.obolibrary.org/obo/MP_0013205 abnormal nonmotile primary cilium morphology any structural anomaly of the single non-motile cilium of a kidney epithelial cell that projects into the luminal space of the tubules and ducts where it is thought to act as a flow sensor http://purl.obolibrary.org/obo/MP_0011066 abnormal renal tubule epithelial cell primary cilium morphology http://purl.obolibrary.org/obo/MP_0011065 abnormal kidney epithelial cell primary cilium morphology any structural anomaly of the single non-motile cilium of a renal tubule epithelial cell that projects into the luminal space of the tubules where it is thought to act as a flow sensor http://purl.obolibrary.org/obo/MP_0011067 abnormal somatostatin level http://purl.obolibrary.org/obo/MP_0003953 abnormal hormone level anomaly of the blood or tissue concentration of a tetradecapeptide capable of inhibiting the release of somatotrophin by the anterior lobe of the pituitary gland and the release of insulin and gastrin from digestive system tissues http://purl.obolibrary.org/obo/MP_0011068 abnormal ependyma motile cilium physiology http://purl.obolibrary.org/obo/MP_0013209 abnormal motile cilium physiology any functional anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain and the central canal of the spinal cord, which beat in concert and to move cerebrospinal fluid around the central nervous system http://purl.obolibrary.org/obo/MP_0011069 abnormal brain ependyma motile cilium physiology http://purl.obolibrary.org/obo/MP_0011068 abnormal ependyma motile cilium physiology any functional anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid http://purl.obolibrary.org/obo/MP_0011070 abnormal spinal cord motile cilium physiology http://purl.obolibrary.org/obo/MP_0011068 abnormal ependyma motile cilium physiology any functional anomaly of the tiny, motile hair-like projections from the epithelial cells that line the central canal of the spinal cord, which beat in concert and to move cerebrospinal fluid http://purl.obolibrary.org/obo/MP_0011071 absent Clara cells http://purl.obolibrary.org/obo/MP_0010949 decreased Clara cell number absence of the rounded, club-shaped, nonciliated cells found between ciliated cells in the bronchiolar epithelium http://purl.obolibrary.org/obo/MP_0011072 abnormal macrophage cytokine production http://purl.obolibrary.org/obo/MP_0002451 abnormal macrophage physiology any anomaly in the appearance of macrophage-derived cytokine(s) due to biosynthesis or secretion following a cellular stimulus, resulting in a change to its intracellular or extracellular levels http://purl.obolibrary.org/obo/MP_0011073 abnormal macrophage apoptosis http://purl.obolibrary.org/obo/MP_0002451 abnormal macrophage physiology excessive or absent cell death in macrophages http://purl.obolibrary.org/obo/MP_0011074 abnormal macrophage nitric oxide production http://purl.obolibrary.org/obo/MP_0003957 abnormal nitric oxide homeostasis any anomaly in the appearance of macrophage-derived nitric oxide due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels http://purl.obolibrary.org/obo/MP_0011075 abnormal macrophage activation involved in immune response http://purl.obolibrary.org/obo/MP_0002451 abnormal macrophage physiology anomaly in the process in which a change in response and behavior of a macrophage results from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response http://purl.obolibrary.org/obo/MP_0011076 increased macrophage nitric oxide production http://purl.obolibrary.org/obo/MP_0011074 abnormal macrophage nitric oxide production greater production of macrophage-derived nitric oxide due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels http://purl.obolibrary.org/obo/MP_0011077 decreased macrophage nitric oxide production http://purl.obolibrary.org/obo/MP_0011074 abnormal macrophage nitric oxide production reduced production of macrophage-derived nitric oxide due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels http://purl.obolibrary.org/obo/MP_0011078 increased macrophage cytokine production http://purl.obolibrary.org/obo/MP_0011072 abnormal macrophage cytokine production greater production of macrophage-derived cytokine(s) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels http://purl.obolibrary.org/obo/MP_0011079 decreased macrophage cytokine production http://purl.obolibrary.org/obo/MP_0011072 abnormal macrophage cytokine production reduced production of macrophage-derived cytokine(s) due to biosynthesis or secretion following a cellular stimulus, resulting in an decrease in its intracellular or extracellular levels http://purl.obolibrary.org/obo/MP_0011080 increased macrophage apoptosis http://purl.obolibrary.org/obo/MP_0011073 abnormal macrophage apoptosis greater incidence of cell death in macrophages http://purl.obolibrary.org/obo/MP_0011081 decreased macrophage apoptosis http://purl.obolibrary.org/obo/MP_0011073 abnormal macrophage apoptosis reduced incidence of cell death in macrophages http://purl.obolibrary.org/obo/MP_0011083 complete lethality at weaning http://purl.obolibrary.org/obo/MP_0008569 lethality at weaning premature death at weaning age of all organisms of a given genotype in a population, often due to the inability to make the transition to solid food http://purl.obolibrary.org/obo/MP_0011084 partial lethality at weaning http://purl.obolibrary.org/obo/MP_0008569 lethality at weaning the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age http://purl.obolibrary.org/obo/MP_0011085 complete postnatal lethality http://purl.obolibrary.org/obo/MP_0002082 postnatal lethality premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age) http://purl.obolibrary.org/obo/MP_0011086 partial postnatal lethality http://purl.obolibrary.org/obo/MP_0002082 postnatal lethality the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age) http://purl.obolibrary.org/obo/MP_0011087 complete neonatal lethality http://purl.obolibrary.org/obo/MP_0002058 neonatal lethality death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0) http://purl.obolibrary.org/obo/MP_0011088 partial neonatal lethality http://purl.obolibrary.org/obo/MP_0002058 neonatal lethality the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0) http://purl.obolibrary.org/obo/MP_0011089 complete perinatal lethality http://purl.obolibrary.org/obo/MP_0002081 perinatal lethality death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1) http://purl.obolibrary.org/obo/MP_0011090 partial perinatal lethality http://purl.obolibrary.org/obo/MP_0002081 perinatal lethality the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1) http://purl.obolibrary.org/obo/MP_0011091 complete prenatal lethality http://purl.obolibrary.org/obo/MP_0002080 prenatal lethality death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5) http://purl.obolibrary.org/obo/MP_0011092 complete embryonic lethality http://purl.obolibrary.org/obo/MP_0008762 embryonic lethality death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14) http://purl.obolibrary.org/obo/MP_0011093 complete embryonic lethality at implantation http://purl.obolibrary.org/obo/MP_0008527 embryonic lethality at implantation death of all organisms of a given genotype in a population at the point of implantation (Mus: E4.5) http://purl.obolibrary.org/obo/MP_0011094 complete embryonic lethality before implantation http://purl.obolibrary.org/obo/MP_0006204 embryonic lethality before implantation death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5) http://purl.obolibrary.org/obo/MP_0011095 complete embryonic lethality between implantation and placentation http://purl.obolibrary.org/obo/MP_0009850 embryonic lethality between implantation and placentation death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9) http://purl.obolibrary.org/obo/MP_0011096 complete embryonic lethality between implantation and somite formation http://purl.obolibrary.org/obo/MP_0006205 embryonic lethality between implantation and somite formation death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8) http://purl.obolibrary.org/obo/MP_0011097 complete embryonic lethality between somite formation and embryo turning http://purl.obolibrary.org/obo/MP_0006206 embryonic lethality between somite formation and embryo turning death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9) http://purl.obolibrary.org/obo/MP_0011098 complete embryonic lethality during organogenesis http://purl.obolibrary.org/obo/MP_0006207 embryonic lethality during organogenesis death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9-9.5 to less than E14) http://purl.obolibrary.org/obo/MP_0011099 complete lethality throughout fetal growth and development http://purl.obolibrary.org/obo/MP_0006208 lethality throughout fetal growth and development death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5) http://purl.obolibrary.org/obo/MP_0011100 complete preweaning lethality http://purl.obolibrary.org/obo/MP_0010770 preweaning lethality death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age) http://purl.obolibrary.org/obo/MP_0011101 partial prenatal lethality http://purl.obolibrary.org/obo/MP_0002080 prenatal lethality the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5) http://purl.obolibrary.org/obo/MP_0011102 partial embryonic lethality http://purl.obolibrary.org/obo/MP_0008762 embryonic lethality the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14) http://purl.obolibrary.org/obo/MP_0011103 partial embryonic lethality at implantation http://purl.obolibrary.org/obo/MP_0008527 embryonic lethality at implantation the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at the point of implantation (Mus: E4.5) http://purl.obolibrary.org/obo/MP_0011104 partial embryonic lethality before implantation http://purl.obolibrary.org/obo/MP_0006204 embryonic lethality before implantation the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and implantation (Mus: E0 to less than E4.5) http://purl.obolibrary.org/obo/MP_0011105 partial embryonic lethality between implantation and placentation http://purl.obolibrary.org/obo/MP_0009850 embryonic lethality between implantation and placentation the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9) http://purl.obolibrary.org/obo/MP_0011106 partial embryonic lethality between implantation and somite formation http://purl.obolibrary.org/obo/MP_0006205 embryonic lethality between implantation and somite formation the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the point of implantation and somite formation (Mus: E4.5 to less than E8) http://purl.obolibrary.org/obo/MP_0011107 partial embryonic lethality between somite formation and embryo turning http://purl.obolibrary.org/obo/MP_0006206 embryonic lethality between somite formation and embryo turning the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between somite formation and the initiation of embryo turning (Mus: E8 to less than E9) http://purl.obolibrary.org/obo/MP_0011108 partial embryonic lethality during organogenesis http://purl.obolibrary.org/obo/MP_0006207 embryonic lethality during organogenesis the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9-9.5 to less than E14) http://purl.obolibrary.org/obo/MP_0011109 partial lethality throughout fetal growth and development http://purl.obolibrary.org/obo/MP_0006208 lethality throughout fetal growth and development the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5) http://purl.obolibrary.org/obo/MP_0011110 partial preweaning lethality http://purl.obolibrary.org/obo/MP_0010770 preweaning lethality the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age) http://purl.obolibrary.org/obo/MP_0011111 complete lethality during fetal growth through weaning http://purl.obolibrary.org/obo/MP_0010832 lethality during fetal growth through weaning death of all organisms of a given genotype in a population between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age) http://purl.obolibrary.org/obo/MP_0011112 partial lethality during fetal growth through weaning http://purl.obolibrary.org/obo/MP_0010832 lethality during fetal growth through weaning the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and weaning age (Mus: E14 to approximately 3 weeks of age) http://purl.obolibrary.org/obo/MP_0011113 abnormal airway basal cell morphology http://purl.obolibrary.org/obo/MP_0010942 abnormal respiratory epithelium morphology any structural anomaly of a long-lived multipotent stem cell of the pseudostratified airway epithelium which is restricted to the tracheal epithelium in mice; airway BCs have been shown to be capable of self renewal, give rise to secretory (Clara) cells and ciliated cells, and play important roles both in epithelial homeostasis and in pathological airway remodeling http://purl.obolibrary.org/obo/MP_0011114 abnormal airway basal cell differentiation http://purl.obolibrary.org/obo/MP_0011113 abnormal airway basal cell morphology abnormal or arrest of differentiation of the long-lived multipotent stem cell population of the pseudostratified airway epithelium; changes in the lineage choice of BCs or their undifferentiated daughters might contribute to the mucous cell hyperplasia, metaplasia or squamous metaplasia seen in many respiratory disorders http://purl.obolibrary.org/obo/MP_0011115 airway basal cell hyperplasia http://purl.obolibrary.org/obo/MP_0011113 abnormal airway basal cell morphology increased number of the long-lived multipotent stem cells of the pseudostratified airway epithelium http://purl.obolibrary.org/obo/MP_0011116 absent Reichert's membrane http://purl.obolibrary.org/obo/MP_0003954 abnormal Reichert's membrane morphology absence of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm during placenta morphogenesis and is secreted by the distal endoderm; normally required for the maternofetal exchange of nutrients and important for postgastrulation development http://purl.obolibrary.org/obo/MP_0011117 abnormal susceptibility to weight gain http://purl.obolibrary.org/obo/MP_0001259 abnormal body weight anomaly in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake http://purl.obolibrary.org/obo/MP_0011118 abnormal susceptibility to weight loss http://purl.obolibrary.org/obo/MP_0001259 abnormal body weight anomaly in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction http://purl.obolibrary.org/obo/MP_0011119 abnormal primordial ovarian follicle number http://purl.obolibrary.org/obo/MP_0009361 abnormal primordial ovarian follicle morphology abnormal numbers of the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles http://purl.obolibrary.org/obo/MP_0011120 increased primordial ovarian follicle number http://purl.obolibrary.org/obo/MP_0011119 abnormal primordial ovarian follicle number greater than normal numbers of the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles http://purl.obolibrary.org/obo/MP_0011121 decreased primordial ovarian follicle number http://purl.obolibrary.org/obo/MP_0011119 abnormal primordial ovarian follicle number fewer than normal numbers of the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles http://purl.obolibrary.org/obo/MP_0011122 absent primordial ovarian follicles http://purl.obolibrary.org/obo/MP_0011121 decreased primordial ovarian follicle number absence of the ovarian follicle in which the primary oocyte is surrounded by a single layer of flattened follicular cells; primordial follicles are indiscernible to the naked eye and develop to primary, secondary, and finally mature vesicular follicles http://purl.obolibrary.org/obo/MP_0011123 abnormal primary ovarian follicle number http://purl.obolibrary.org/obo/MP_0008871 abnormal ovarian follicle number abnormal numbers of the ovarian follicle prior to the appearance of an antrum, normally marked by developmental changes in the primary oocyte and follicular cells so that the latter form one or more layers of cuboidal or columnar cells; the follicle becomes surrounded by a sheath of stroma, the theca http://purl.obolibrary.org/obo/MP_0011124 increased primary ovarian follicle number http://purl.obolibrary.org/obo/MP_0011123 abnormal primary ovarian follicle number greater than normal numbers of the ovarian follicle prior to the appearance of an antrum, normally marked by developmental changes in the primary oocyte and follicular cells so that the latter form one or more layers of cuboidal or columnar cells; the follicle becomes surrounded by a sheath of stroma, the theca http://purl.obolibrary.org/obo/MP_0011125 decreased primary ovarian follicle number http://purl.obolibrary.org/obo/MP_0011123 abnormal primary ovarian follicle number fewer than normal numbers of the ovarian follicle prior to the appearance of an antrum, normally marked by developmental changes in the primary oocyte and follicular cells so that the latter form one or more layers of cuboidal or columnar cells; the follicle becomes surrounded by a sheath of stroma, the theca http://purl.obolibrary.org/obo/MP_0011126 absent primary ovarian follicles http://purl.obolibrary.org/obo/MP_0011125 decreased primary ovarian follicle number absence of the ovarian follicle prior to the appearance of an antrum, normally marked by developmental changes in the primary oocyte and follicular cells so that the latter form one or more layers of cuboidal or columnar cells; the follicle becomes surrounded by a sheath of stroma, the theca http://purl.obolibrary.org/obo/MP_0011127 abnormal secondary ovarian follicle number http://purl.obolibrary.org/obo/MP_0009363 abnormal secondary ovarian follicle morphology abnormal numbers of the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers http://purl.obolibrary.org/obo/MP_0011128 increased secondary ovarian follicle number http://purl.obolibrary.org/obo/MP_0011127 abnormal secondary ovarian follicle number greater than normal numbers of the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers http://purl.obolibrary.org/obo/MP_0011129 decreased secondary ovarian follicle number http://purl.obolibrary.org/obo/MP_0011127 abnormal secondary ovarian follicle number fewer than normal numbers of the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers http://purl.obolibrary.org/obo/MP_0011130 absent secondary ovarian follicles http://purl.obolibrary.org/obo/MP_0011129 decreased secondary ovarian follicle number absence of the ovarian follicle in which the primary oocyte attains its full size and is surrounded by an extracellular glycoprotein layer (zona pellucida) that separates it from a peripheral layer of follicular cells permeated by one or more fluid-filled antra; the primary oocyte occupies the cumulus oophorus while the theca of the follicle develops into internal and external layers http://purl.obolibrary.org/obo/MP_0011131 abnormal lung endothelial cell physiology http://purl.obolibrary.org/obo/MP_0002133 abnormal respiratory system physiology any functional anomaly of the squamous cells forming the lining of the pulmonary vasculature http://purl.obolibrary.org/obo/MP_0011132 abnormal lung endothelial cell migration http://purl.obolibrary.org/obo/MP_0011131 abnormal lung endothelial cell physiology anomaly in the movement of endothelial cells or their precursors to the appropriate location in the pulmonary vasculature http://purl.obolibrary.org/obo/MP_0011133 increased lung endothelial cell migration http://purl.obolibrary.org/obo/MP_0011804 increased cell migration increased or faster movement of endothelial cells or their precursors to the appropriate location in the pulmonary vasculature http://purl.obolibrary.org/obo/MP_0011134 decreased lung endothelial cell migration http://purl.obolibrary.org/obo/MP_0011805 decreased cell migration reduced or slower movement of endothelial cells or their precursors to the appropriate location in the pulmonary vasculature http://purl.obolibrary.org/obo/MP_0011135 abnormal lung endothelial cell adhesion http://purl.obolibrary.org/obo/MP_0011131 abnormal lung endothelial cell physiology altered ability of an endothelial cell in the pulmonary vasculature to adhere to another cell or to a non-cellular component of the environment http://purl.obolibrary.org/obo/MP_0011136 increased lung endothelial cell adhesion http://purl.obolibrary.org/obo/MP_0011135 abnormal lung endothelial cell adhesion increased ability of an endothelial cell in the pulmonary vasculature to adhere to another cell or to a non-cellular component of the environment http://purl.obolibrary.org/obo/MP_0011137 decreased lung endothelial cell adhesion http://purl.obolibrary.org/obo/MP_0011135 abnormal lung endothelial cell adhesion decreased ability of an endothelial cell in the pulmonary vasculature to adhere to another cell or to a non-cellular component of the environment http://purl.obolibrary.org/obo/MP_0011138 abnormal lung endothelial cell proliferation http://purl.obolibrary.org/obo/MP_0011131 abnormal lung endothelial cell physiology altered ability of an endothelial cell in the pulmonary vasculature to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0011139 increased lung endothelial cell proliferation http://purl.obolibrary.org/obo/MP_0011138 abnormal lung endothelial cell proliferation greater ability of an endothelial cell in the pulmonary vasculature to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0011140 decreased lung endothelial cell proliferation http://purl.obolibrary.org/obo/MP_0011138 abnormal lung endothelial cell proliferation reduced ability of an endothelial cell in the pulmonary vasculature to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0011141 increased lung endothelial cell apoptosis http://purl.obolibrary.org/obo/MP_0011131 abnormal lung endothelial cell physiology acceleration in the timing or in the number of endothelial cells in the pulmonary vasculature to undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0011142 abnormal lung-associated mesenchyme development http://purl.obolibrary.org/obo/MP_0001176 abnormal lung development abnormality in the formation of the lung tissue comprised of multiple cell types (including connective tissue, endothelial cells, lymphatics, smooth muscle cells surrounding airways and blood vessels, myofibroblasts involved in septum formation, and cartilage-forming cells in the trachea), with most cells thought to be derived from the splanchnic mesenchyme, and other cells (endothelial, smooth muscle) believed to invade the lung as it expands; lung mesenchyme is a critical determinant of the shape and size of the developing lung, the extent and patterning of epithelial branching, and the formation of the pulmonary vasculature and interstitial mesenchymal components of the adult lung http://purl.obolibrary.org/obo/MP_0011143 thick lung-associated mesenchyme http://purl.obolibrary.org/obo/MP_0001176 abnormal lung development increased thickness of the mesenchymal cell layer due to delay or failure of the mesenchymal compartment to thin down during the late stages of embryonic lung development http://purl.obolibrary.org/obo/MP_0011144 thin lung-associated mesenchyme http://purl.obolibrary.org/obo/MP_0001176 abnormal lung development decreased thickness of the mesenchymal cell layer in the developing lung http://purl.obolibrary.org/obo/MP_0011145 abnormal mesenchymal cell differentiation involved in lung development http://purl.obolibrary.org/obo/MP_0005076 abnormal cell differentiation abnormal or arrest of differentiation of the mesenchymal cell population in the developing lung http://purl.obolibrary.org/obo/MP_0011146 abnormal mesenchymal cell proliferation involved in lung development http://purl.obolibrary.org/obo/MP_0001176 abnormal lung development anomaly in the ability of the differentiating lung mesenchymal cell population to undergo expansion by cell division in the developing lung http://purl.obolibrary.org/obo/MP_0011147 increased mesenchymal cell proliferation involved in lung development http://purl.obolibrary.org/obo/MP_0011146 abnormal mesenchymal cell proliferation involved in lung development increase in the expansion rate of a lung mesenchymal cell population by cell division http://purl.obolibrary.org/obo/MP_0011148 decreased mesenchymal cell proliferation involved in lung development http://purl.obolibrary.org/obo/MP_0011146 abnormal mesenchymal cell proliferation involved in lung development reduction in the expansion rate of a lung mesenchymal cell population by cell division http://purl.obolibrary.org/obo/MP_0011156 abnormal hypodermis fat layer morphology http://purl.obolibrary.org/obo/MP_0003705 abnormal hypodermis morphology any structural anomaly of the superficial portion of the subcutaneous tissue which is specialized for fat storage http://purl.obolibrary.org/obo/MP_0011157 abnormal hypodermis muscle layer morphology http://purl.obolibrary.org/obo/MP_0003705 abnormal hypodermis morphology any structural anomaly of the skeletal muscle layer in the superficial fascia http://purl.obolibrary.org/obo/MP_0011158 absent hypodermis muscle layer http://purl.obolibrary.org/obo/MP_0011157 abnormal hypodermis muscle layer morphology absence of the skeletal muscle layer in the superficial fascia http://purl.obolibrary.org/obo/MP_0011159 abnormal epidermal-dermal junction morphology http://purl.obolibrary.org/obo/MP_0002060 abnormal skin morphology any structural anomaly of the multi-layer basement membrane between the dermis and epidermis that serves to adhere the dermis and epidermis, provide mechanical support for the epidermis, and forms a barrier to cells and large molecules across the junction http://purl.obolibrary.org/obo/MP_0011160 dermal-epidermal separation http://purl.obolibrary.org/obo/MP_0011159 abnormal epidermal-dermal junction morphology the appearance of gaps or clefts in the normally continuous junctional interface between the dermis and epidermis http://purl.obolibrary.org/obo/MP_0011161 increased hypodermis neovascularization http://purl.obolibrary.org/obo/MP_0003711 pathological neovascularization new or excessive vessel proliferation in the irregular layer of loose connective tissue containing fibroblasts, adipose cells, and macrophages, that is immediately deep to the skin and superficial to the deep fascia http://purl.obolibrary.org/obo/MP_0011162 abnormal wet-to-dry lung weight ratio http://purl.obolibrary.org/obo/MP_0005629 abnormal lung weight any deviation from the standard ratio, calculated by dividing the wet lung weight (measured immediately after lung excision) to the oven-dried lung weight, compared to control samples; may be used as an index of extravascular fluid accumulation (pulmonary edema) and/or tissue damage after lung injury http://purl.obolibrary.org/obo/MP_0011163 increased wet-to-dry lung weight ratio http://purl.obolibrary.org/obo/MP_0011162 abnormal wet-to-dry lung weight ratio an increase in the ratio of wet lung weight (measured immediately after lung excision) to oven-dried lung weight relative to control samples; may reflect an inability to expel remaining amniotic fluid out of the lungs during or shortly after birth, or increased fluid accumulation (pulmonary edema) and/or tissue damage after lung injury http://purl.obolibrary.org/obo/MP_0011164 panniculitis http://purl.obolibrary.org/obo/MP_0010680 abnormal skin adnexa physiology inflammation of the subcutaneous adipose tissue http://purl.obolibrary.org/obo/MP_0011165 abnormal tooth root development http://purl.obolibrary.org/obo/MP_0000116 abnormal tooth development aberrant or incomplete formation of the part of a tooth that is implanted in the gum; the root is normally located below the neck of the tooth, covered by cementum rather than enamel, and attached by the periodontal ligament to the alveolar bone http://purl.obolibrary.org/obo/MP_0011166 absent molar root http://purl.obolibrary.org/obo/MP_0011165 abnormal tooth root development absence of the part of a molar tooth that is implanted in the gum; mandibular and maxillary molars usually have two and three roots, respectively http://purl.obolibrary.org/obo/MP_0011167 abnormal adipose tissue development http://purl.obolibrary.org/obo/MP_0000003 abnormal adipose tissue morphology anomaly in the process of the formation of the connective tissue composed of fat cells enmeshed in areolar tissue http://purl.obolibrary.org/obo/MP_0011168 abnormal fat cell differentiation http://purl.obolibrary.org/obo/MP_0009115 abnormal fat cell morphology abnormal or arrest of differentiation of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals http://purl.obolibrary.org/obo/MP_0011169 abnormal white fat cell differentation http://purl.obolibrary.org/obo/MP_0011168 abnormal fat cell differentiation abnormal or arrest of differentiation of fat cells with light coloration and few mitochondria; these contain a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole http://purl.obolibrary.org/obo/MP_0011170 abnormal brown fat cell differentiation http://purl.obolibrary.org/obo/MP_0011168 abnormal fat cell differentiation abnormal or arrest of differentiation of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals http://purl.obolibrary.org/obo/MP_0011171 increased number of Heinz bodies http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology presence of intracellular inclusions usually attached to the red blood cell membrane, resulting from oxidative injury to and precipitation of hemoglobin in red blood cells http://purl.obolibrary.org/obo/MP_0011172 abnormal otic pit morphology http://purl.obolibrary.org/obo/MP_0003938 abnormal ear development any structural anomaly of the pair of depressions of thickened otic placode epithelium, that further develops into the otic vesicles http://purl.obolibrary.org/obo/MP_0011173 abnormal otic placode morphology http://purl.obolibrary.org/obo/MP_0003938 abnormal ear development any structural anomaly of two paired thickened areas of ectoderm close to the hindbrain from which the vestibular system and the auditory system develops; the otic placode invaginates into the mesenchyme adjacent to the rhombencephalon to form the otic pit http://purl.obolibrary.org/obo/MP_0011174 lipodystrophy http://purl.obolibrary.org/obo/MP_0010025 decreased total body fat amount abnormal or degenerative conditions of the body's adipose tissue resulting in bodily or focal loss and the appearance of redistribution of fat tissue; adipose tissue loss may be total, partial, or localized http://purl.obolibrary.org/obo/MP_0011175 platyspondylia http://purl.obolibrary.org/obo/MP_0000141 abnormal vertebral body morphology flatness of the bodies of the vertebrae; one or many vertebrae may be affected http://purl.obolibrary.org/obo/MP_0011176 abnormal erythroblast morphology http://purl.obolibrary.org/obo/MP_0002416 abnormal proerythroblast morphology any structural anomaly of the nucleated precursor of erythrocytes http://purl.obolibrary.org/obo/MP_0011177 abnormal erythroblast number http://purl.obolibrary.org/obo/MP_0011176 abnormal erythroblast morphology altered number of the nucleated precursor of erythrocytes http://purl.obolibrary.org/obo/MP_0011178 increased erythroblast number http://purl.obolibrary.org/obo/MP_0011177 abnormal erythroblast number greater number of the nucleated precursor of erythrocytes http://purl.obolibrary.org/obo/MP_0011179 decreased erythroblast number http://purl.obolibrary.org/obo/MP_0011177 abnormal erythroblast number reduced number of the nucleated precursor of erythrocytes http://purl.obolibrary.org/obo/MP_0011183 abnormal primitive endoderm morphology http://purl.obolibrary.org/obo/MP_0012103 abnormal bilaminar embryonic disc any structural anomaly of the transient thin monolayer of cuboidal cells that comprise the lower layer of the bilaminar embryonic disk; the hypoblast cells contribute to several extraembryonic structures, but do not contribute to the embryo http://purl.obolibrary.org/obo/MP_0011184 absent embryonic epiblast http://purl.obolibrary.org/obo/MP_0003886 abnormal embryonic epiblast morphology absence of the transient structure derived from the inner cell mass which lies above the hypoblast; the epiblast tissue gives rise to the three primary germ layers (ectoderm, definitive endoderm, and mesoderm) and to the extraembryonic mesoderm of the visceral yolk sac, the allantois, and the amnion http://purl.obolibrary.org/obo/MP_0011185 absent primitive endoderm http://purl.obolibrary.org/obo/MP_0011183 abnormal primitive endoderm morphology absence of the transient thin monolayer of cuboidal cells that comprise the lower layer of the bilaminar embryonic disk; the hypoblast cells contribute to several extraembryonic structures, but do not contribute to the embryo http://purl.obolibrary.org/obo/MP_0011186 abnormal visceral endoderm morphology http://purl.obolibrary.org/obo/MP_0001672 abnormal embryogenesis/ development any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut http://purl.obolibrary.org/obo/MP_0011188 increased erythrocyte protoporphyrin level http://purl.obolibrary.org/obo/MP_0004147 increased porphyrin level an accumulation of the intermediates of heme biosynthesis in red blood cells http://purl.obolibrary.org/obo/MP_0011189 small embryonic epiblast http://purl.obolibrary.org/obo/MP_0003886 abnormal embryonic epiblast morphology reduced size of the transient structure derived from the inner cell mass which lies above the hypoblast; the epiblast tissue gives rise to the three primary germ layers (ectoderm, definitive endoderm, and mesoderm) and to the extraembryonic mesoderm of the visceral yolk sac, the allantois, and the amnion http://purl.obolibrary.org/obo/MP_0011190 thick embryonic epiblast http://purl.obolibrary.org/obo/MP_0003886 abnormal embryonic epiblast morphology increased thickness of the transient structure derived from the inner cell mass which lies above the hypoblast; the epiblast tissue gives rise to the three primary germ layers (ectoderm, definitive endoderm, and mesoderm) and to the extraembryonic mesoderm of the visceral yolk sac, the allantois, and the amnion http://purl.obolibrary.org/obo/MP_0011191 increased embryonic epiblast cell apoptosis http://purl.obolibrary.org/obo/MP_0006042 increased apoptosis increase in the number of embryonic epiblast cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0011192 decreased embryonic epiblast cell proliferation http://purl.obolibrary.org/obo/MP_0003886 abnormal embryonic epiblast morphology reduction in the expansion rate of the embryonic epiblast cells by cell division http://purl.obolibrary.org/obo/MP_0011193 embryonic epiblast cell degeneration http://purl.obolibrary.org/obo/MP_0003886 abnormal embryonic epiblast morphology a retrogressive impairment of function or destruction of the cells comprising the transient structure derived from the inner cell mass which lies above the hypoblast; the epiblast tissue gives rise to the three primary germ layers (ectoderm, definitive endoderm, and mesoderm) and to the extraembryonic mesoderm of the visceral yolk sac, the allantois, and the amnion http://purl.obolibrary.org/obo/MP_0011194 abnormal hair follicle physiology http://purl.obolibrary.org/obo/MP_0010680 abnormal skin adnexa physiology any functional anomaly of the invagination of the epidermis from which the hair shaft develops http://purl.obolibrary.org/obo/MP_0011195 increased hair follicle apoptosis http://purl.obolibrary.org/obo/MP_0011194 abnormal hair follicle physiology greater than expected levels of programmed cell death of cells in the epidermis from which the hair shaft develops http://purl.obolibrary.org/obo/MP_0011196 decreased hair follicle apoptosis http://purl.obolibrary.org/obo/MP_0011194 abnormal hair follicle physiology reduced from expected levels of programmed cell death of cells in the epidermis from which the hair shaft develops http://purl.obolibrary.org/obo/MP_0011197 abnormal proamniotic cavity morphology http://purl.obolibrary.org/obo/MP_0002086 abnormal extraembryonic tissue morphology any structural anomaly of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds http://purl.obolibrary.org/obo/MP_0011198 absent proamniotic cavity http://purl.obolibrary.org/obo/MP_0011197 abnormal proamniotic cavity morphology absence of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds http://purl.obolibrary.org/obo/MP_0011199 abnormal amniotic cavity morphology http://purl.obolibrary.org/obo/MP_0002086 abnormal extraembryonic tissue morphology any structural anomaly of the closed space between the embryo and the amnion, containing the amniotic fluid; it is formed by the fusion of the parts of the anterior and posterior amniotic folds http://purl.obolibrary.org/obo/MP_0011200 abnormal extraembryonic coelom morphology http://purl.obolibrary.org/obo/MP_0002086 abnormal extraembryonic tissue morphology any structural anomaly of the fluid-filled spaces formed within the mass of extraembryonic mesoderm that later fuse to become a large extraembryonic cavity http://purl.obolibrary.org/obo/MP_0011201 abnormal visceral yolk sac cavity morphology http://purl.obolibrary.org/obo/MP_0002086 abnormal extraembryonic tissue morphology any structural anomaly of the closed space containing the yolk, formed by the fusion of the edges of the embryonic epiblast (hypoblast) and later surrounded by the visceral yolk sac (hypoblast and visceral yolk sac mesoderm) http://purl.obolibrary.org/obo/MP_0011202 abnormal ectoplacental cavity morphology http://purl.obolibrary.org/obo/MP_0002086 abnormal extraembryonic tissue morphology any structural anomaly of the closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity http://purl.obolibrary.org/obo/MP_0011203 abnormal parietal yolk sac morphology http://purl.obolibrary.org/obo/MP_0002086 abnormal extraembryonic tissue morphology any structural anomaly of the tissue that consists of two cellular layers (parietal endoderm and trophoblast) separated by a relatively thick nonvascular basement membrane (Reichert's membrane), and acts as a protective layer to supports and facilitates transport of nutrients between the uterine tissue and the yolk sac cavity http://purl.obolibrary.org/obo/MP_0011205 excessive folding of visceral yolk sac http://purl.obolibrary.org/obo/MP_0001718 abnormal visceral yolk sac morphology the appearance of wrinkles or folds on the surface of the visceral yolk sac http://purl.obolibrary.org/obo/MP_0011206 absent visceral yolk sac http://purl.obolibrary.org/obo/MP_0001718 abnormal visceral yolk sac morphology absence of the extraembryonic tissue membrane, formed from the visceral endoderm and the extraembryonic mesoderm, which is located ventral to the embryonic disc and is connected to the presumptive midgut of the embryo http://purl.obolibrary.org/obo/MP_0011207 absent ectoplacental cavity http://purl.obolibrary.org/obo/MP_0011202 abnormal ectoplacental cavity morphology absence of the closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity http://purl.obolibrary.org/obo/MP_0011208 small proamniotic cavity http://purl.obolibrary.org/obo/MP_0011197 abnormal proamniotic cavity morphology reduced size of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds http://purl.obolibrary.org/obo/MP_0011209 absent extraembryonic coelom http://purl.obolibrary.org/obo/MP_0011200 abnormal extraembryonic coelom morphology absence of the fluid-filled spaces formed within the mass of extraembryonic mesoderm that later fuse to become a large extraembryonic cavity http://purl.obolibrary.org/obo/MP_0011210 abnormal temporomandibular joint morphology http://purl.obolibrary.org/obo/MP_0002932 abnormal joint morphology any structural anomaly of the synovial articulation between the head of the mandibular condoyloid process and the mandibular fossa and articular tubercle of the temporal bones http://purl.obolibrary.org/obo/MP_0011211 abnormal common peroneal nerve morphology http://purl.obolibrary.org/obo/MP_0002752 abnormal somatic nervous system morphology any structural anomaly of a nerve arising at the terminal division of the sciatic nerve at the popliteal fossa and extending to the neck of the fibula, ultimately innervating the Peroneus muscles http://purl.obolibrary.org/obo/MP_0011212 absent common peroneal nerve http://purl.obolibrary.org/obo/MP_0011211 abnormal common peroneal nerve morphology absence of the nerve arising at the terminal division of the sciatic nerve at the popliteal fossa and extending to the neck of the fibula, ultimately innervating the Peroneus muscles http://purl.obolibrary.org/obo/MP_0011213 abnormal brain copper level http://purl.obolibrary.org/obo/MP_0003952 abnormal copper level an anomaly in the amount of copper present in brain tissue http://purl.obolibrary.org/obo/MP_0011214 increased brain copper level http://purl.obolibrary.org/obo/MP_0011213 abnormal brain copper level a greater accumulation of copper in the brain tissue compared to controls http://purl.obolibrary.org/obo/MP_0011215 decreased brain copper level http://purl.obolibrary.org/obo/MP_0011213 abnormal brain copper level a reduced amount of copper in the brain tissue compared to controls http://purl.obolibrary.org/obo/MP_0011216 abnormal brainstem copper level http://purl.obolibrary.org/obo/MP_0011213 abnormal brain copper level an anomaly in the amount of copper present in brainstem tissue http://purl.obolibrary.org/obo/MP_0011217 increased brainstem copper level http://purl.obolibrary.org/obo/MP_0011216 abnormal brainstem copper level a greater accumulation of copper in the brainstem tissue compared to controls http://purl.obolibrary.org/obo/MP_0011218 decreased brainstem copper level http://purl.obolibrary.org/obo/MP_0011216 abnormal brainstem copper level a reduced amount of copper in the brainstem tissue compared to controls http://purl.obolibrary.org/obo/MP_0011219 abnormal intestinal calcium absorption http://purl.obolibrary.org/obo/MP_0001670 abnormal intestinal mineral absorption any anomaly in the ability of the body to take up calcium into the blood by absorption from the small intestine http://purl.obolibrary.org/obo/MP_0011220 increased intestinal calcium absorption http://purl.obolibrary.org/obo/MP_0011219 abnormal intestinal calcium absorption augmented ability of the body to take up calcium into the blood by absorption from the small intestine http://purl.obolibrary.org/obo/MP_0011221 decreased intestinal calcium absorption http://purl.obolibrary.org/obo/MP_0011219 abnormal intestinal calcium absorption reduced ability of the body to take up calcium into the blood by absorption from the small intestine http://purl.obolibrary.org/obo/MP_0011222 abnormal lymph node medullary sinus morphology http://purl.obolibrary.org/obo/MP_0002348 abnormal lymph node medulla morphology any structural anomaly of the channels in the lymph node medulla that separate the medullary cords and are crossed by a reticulum of cells and fibers and bounded by littoral cells; lymph flows through the medullary sinus from the cortical sinuses and into the efferent lymphatic vessels http://purl.obolibrary.org/obo/MP_0011223 dilated lymph node medullary sinus http://purl.obolibrary.org/obo/MP_0011222 abnormal lymph node medullary sinus morphology the luminal space of the lymph node medulla is increased in volume or area, usually with an increase in contained fluid http://purl.obolibrary.org/obo/MP_0011224 abnormal lymph node medullary cord morphology http://purl.obolibrary.org/obo/MP_0002348 abnormal lymph node medulla morphology any structural anomaly of the dense rope-like structures of lymphatic tissue located between the medullary sinuses in the medulla of a lymph node http://purl.obolibrary.org/obo/MP_0011225 lymph node medullary cord hyperplasia http://purl.obolibrary.org/obo/MP_0011224 abnormal lymph node medullary cord morphology increase in the number of normal cells in normal arrangement in the lymph node medullary cords, resulting in a thickening or enlargement of the structure, caused by stimuli including increased physiological demand, inflammatory response, hormonal changes or hormonal dysfunctions, and/or compensation due to a pathological cause elsewhere http://purl.obolibrary.org/obo/MP_0011226 abnormal thiamin level http://purl.obolibrary.org/obo/MP_0005400 abnormal vitamin level any anomaly in the concentration of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver http://purl.obolibrary.org/obo/MP_0011227 abnormal vitamin B12 level http://purl.obolibrary.org/obo/MP_0005400 abnormal vitamin level any anomaly in the concentration of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom http://purl.obolibrary.org/obo/MP_0011228 abnormal vitamin D level http://purl.obolibrary.org/obo/MP_0005401 abnormal fat-soluble vitamin level any anomaly in the concentration of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3) http://purl.obolibrary.org/obo/MP_0011229 abnormal vitamin C level http://purl.obolibrary.org/obo/MP_0005400 abnormal vitamin level any anomaly in the concentration of L-ascorbic acid (vitamin C), which is a common co-factor and has anti-oxidant activities in many species http://purl.obolibrary.org/obo/MP_0011230 abnormal folic acid level http://purl.obolibrary.org/obo/MP_0005400 abnormal vitamin level any anomaly in the concentration of the vitamin B family member that stimulates the hematopoietic system, is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses, and is used in the treatment and prevention of folate deficiencies and megaloblastic anemia http://purl.obolibrary.org/obo/MP_0011231 abnormal vitamin E level http://purl.obolibrary.org/obo/MP_0005401 abnormal fat-soluble vitamin level any anomaly in the concentration of vitamin E, tocopherol, including a series of eight structurally similar compounds; alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant http://purl.obolibrary.org/obo/MP_0011232 abnormal vitamin A level http://purl.obolibrary.org/obo/MP_0005401 abnormal fat-soluble vitamin level any anomaly in the concentration of any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid; animals can not synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids supplied in the diet http://purl.obolibrary.org/obo/MP_0011233 abnormal vitamin A metabolism http://purl.obolibrary.org/obo/MP_0013244 abnormal vitamin metabolism altered ability to metabolize any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid; animals can not synthesize vitamin A de novo, but form it through oxidative cleavage of carotenoids supplied in the diet http://purl.obolibrary.org/obo/MP_0011234 abnormal retinol level http://purl.obolibrary.org/obo/MP_0011232 abnormal vitamin A level any anomaly in the concentration of retinol, which plays an essential role in metabolic functioning of the retina, and growth and differentiation http://purl.obolibrary.org/obo/MP_0011235 abnormal blood oxygen capacity http://purl.obolibrary.org/obo/MP_0009642 abnormal blood homeostasis the maximum amount of oxygen that will combine chemically with a given amount of hemoglobin in a unit volume of blood is not as expected http://purl.obolibrary.org/obo/MP_0011236 increased blood oxygen capacity http://purl.obolibrary.org/obo/MP_0011235 abnormal blood oxygen capacity an increase in the maximum amount of oxygen that will combine chemically with a given amount of hemoglobin in a unit volume of blood http://purl.obolibrary.org/obo/MP_0011237 decreased blood oxygen capacity http://purl.obolibrary.org/obo/MP_0011235 abnormal blood oxygen capacity a decrease in the maximum amount of oxygen that will combine chemically with a given amount of hemoglobin in a unit volume of blood http://purl.obolibrary.org/obo/MP_0011238 abnormal inner ear development http://purl.obolibrary.org/obo/MP_0003938 abnormal ear development atypical initial production, differentiation, migration or maturation of the labyrinth, including the semicircular canals, vestibule and cochlea http://purl.obolibrary.org/obo/MP_0011240 abnormal fetal derived definitive erythrocyte morphology http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology any structural anomaly of a fetal liver derived enucleated erythrocyte, which matures in macrophage islands within the liver, enucleates, and then enters the bloodstream; these resemble adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemoglobins http://purl.obolibrary.org/obo/MP_0011241 abnormal fetal derived definitive erythrocyte cell number http://purl.obolibrary.org/obo/MP_0011240 abnormal fetal derived definitive erythrocyte morphology anomaly in the number of a fetal liver derived enucleated erythrocytes, which mature in macrophage islands within the liver, enucleate, and then enter the bloodstream; these resemble adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemoglobins http://purl.obolibrary.org/obo/MP_0011242 increased fetal derived definitive erythrocyte cell number http://purl.obolibrary.org/obo/MP_0011241 abnormal fetal derived definitive erythrocyte cell number increased number of fetal liver derived enucleated erythrocytes, which mature in macrophage islands within the liver, enucleate, and then enter the bloodstream; these resemble adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemoglobins http://purl.obolibrary.org/obo/MP_0011243 decreased fetal derived definitive erythrocyte cell number http://purl.obolibrary.org/obo/MP_0011241 abnormal fetal derived definitive erythrocyte cell number reduced number of fetal liver derived enucleated erythrocytes, which mature in macrophage islands within the liver, enucleate, and then enter the bloodstream; these resemble adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemoglobins http://purl.obolibrary.org/obo/MP_0011244 absent fetal derived definitive erythrocytes http://purl.obolibrary.org/obo/MP_0011243 decreased fetal derived definitive erythrocyte cell number absence of fetal liver derived enucleated erythrocytes, which mature in macrophage islands within the liver, enucleate, and then enter the bloodstream; these resemble adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemoglobins http://purl.obolibrary.org/obo/MP_0011245 abnormal fetal derived definitive erythrocyte physiology http://purl.obolibrary.org/obo/MP_0003656 abnormal erythrocyte physiology any functional anomaly of a fetal liver derived enucleated erythrocyte, which matures in macrophage islands within the liver, enucleates, and then enters the bloodstream; these resemble adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemoglobins http://purl.obolibrary.org/obo/MP_0011246 abnormal fetal liver hematopoietic progenitor cell morphology http://purl.obolibrary.org/obo/MP_0004808 abnormal hematopoietic stem cell morphology any structural anomaly of a hematopoietic stem cell that resides in the fetal liver http://purl.obolibrary.org/obo/MP_0011247 abnormal yolk sac hematopoietic stem cell morphology http://purl.obolibrary.org/obo/MP_0004808 abnormal hematopoietic stem cell morphology any structural anomaly of a hematopoietic stem found in the yolk sac http://purl.obolibrary.org/obo/MP_0011248 visceral organ asymmetry http://purl.obolibrary.org/obo/MP_0004133 heterotaxia lateral duplication of some or all internal organs http://purl.obolibrary.org/obo/MP_0011249 abdominal situs inversus http://purl.obolibrary.org/obo/MP_0004133 heterotaxia lateral transposition or mirroring of the viscera of the abdomen, sometimes incomplete, with all organs maintaining the normal relative position with respect to each other http://purl.obolibrary.org/obo/MP_0011250 abdominal situs ambiguus http://purl.obolibrary.org/obo/MP_0004133 heterotaxia an abnormality in which the abdominal organs are positioned in such a way with respect to each other and the left-right axis as to be not clearly lateralised and thus have neither the usual, or normal (situs solitus), nor the mirror-imaged (situs inversus) arrangements http://purl.obolibrary.org/obo/MP_0011251 bronchial situs inversus http://purl.obolibrary.org/obo/MP_0010854 lung situs inversus anomaly in the asymmetry of the bronchi of the lung such that these structures on both the left and right side have the morphology normally seen on the opposite side of the body http://purl.obolibrary.org/obo/MP_0011252 situs inversus totalis http://purl.obolibrary.org/obo/MP_0002766 situs inversus the complete right to left reversal (transposition) of the thoracic and abdominal organs, including the heart (dextrocardia) http://purl.obolibrary.org/obo/MP_0011253 situs inversus with levocardia http://purl.obolibrary.org/obo/MP_0002766 situs inversus situs inversus of thoracic and abdominal viscera with the heart remaining normally situated on the left; usually associated with congenital cardiac abnormalities such as transposition of the great vessels and/or spleen defects including asplenia or polysplenia http://purl.obolibrary.org/obo/MP_0011254 superior-inferior ventricles http://purl.obolibrary.org/obo/MP_0006065 abnormal heart position or orientation an abnormality in which the heart ventricles are in a superior-inferior relationship due to abnormal displacement of the ventricular mass along the horizontal plane of its long axis; this frequently occurs together with criss-cross atrio-ventricular relationships http://purl.obolibrary.org/obo/MP_0011255 abnormal anterior visceral endoderm cell migration http://purl.obolibrary.org/obo/MP_0012028 abnormal visceral endoderm physiology any anomaly in the movement of the cells of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue http://purl.obolibrary.org/obo/MP_0011256 abnormal neural fold morphology http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology any structural anomaly of the elevated margins of the neural groove http://purl.obolibrary.org/obo/MP_0011257 abnormal head fold morphology http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology any structural anomaly of the crescent-shaped, ventrally located fold of the embryonic disc at the future cephalic end of the developing embryo; it constitutes the first body fold, and initiates brain, foregut and heart development http://purl.obolibrary.org/obo/MP_0011258 abnormal tail fold morphology http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology any structural anomaly of the crescent-shaped, ventrally located fold of the embryonic disc at the future caudal end of the developing embryo http://purl.obolibrary.org/obo/MP_0011259 abnormal cephalic neural fold morphology http://purl.obolibrary.org/obo/MP_0011256 abnormal neural fold morphology any structural anomaly of the elevated margins of the neural groove that are located in the future cephalic region of the embryo http://purl.obolibrary.org/obo/MP_0011261 abnormal limb mesenchyme morphology http://purl.obolibrary.org/obo/MP_0005650 abnormal limb bud morphology any structural anomaly in the primordial embryonic connective tissue of the developing limbs, autopods and digits, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to limb connective tissue, bone and musculature in conjunction with myotome cells http://purl.obolibrary.org/obo/MP_0011262 abnormal pharyngeal arch mesenchyme morphology http://purl.obolibrary.org/obo/MP_0010395 abnormal pharyngeal arch development any structural anomaly in the primordial embryonic connective tissue associated with the branchial arches, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to facial and cranial nerve-associated structures http://purl.obolibrary.org/obo/MP_0011263 abnormal spleen mesenchyme morphology http://purl.obolibrary.org/obo/MP_0009323 abnormal spleen development any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing spleen http://purl.obolibrary.org/obo/MP_0011264 abnormal cardiac mesenchyme morphology http://purl.obolibrary.org/obo/MP_0002925 abnormal cardiovascular development any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing cardiac structures http://purl.obolibrary.org/obo/MP_0011265 abnormal pancreas mesenchyme morphology http://purl.obolibrary.org/obo/MP_0003934 abnormal pancreas development any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing pancreas http://purl.obolibrary.org/obo/MP_0011266 abnormal frontonasal mesenchyme morphology http://purl.obolibrary.org/obo/MP_0011260 abnormal head mesenchyme morphology any structural anomaly of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the frontonasal region of the head http://purl.obolibrary.org/obo/MP_0011267 abnormal excitatory postsynaptic current amplitude http://purl.obolibrary.org/obo/MP_0002910 abnormal excitatory postsynaptic currents anomaly in the size (height or maximum displacement) or shape of the evoked excitatory postsynaptic current wave http://purl.obolibrary.org/obo/MP_0011268 biphasic excitatory postsynaptic current amplitude http://purl.obolibrary.org/obo/MP_0011267 abnormal excitatory postsynaptic current amplitude the appearance of two peaks instead of one peak in the evoked excitatory postsynaptic current wave http://purl.obolibrary.org/obo/MP_0011269 increased excitatory postsynaptic current amplitude http://purl.obolibrary.org/obo/MP_0011267 abnormal excitatory postsynaptic current amplitude increase in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave http://purl.obolibrary.org/obo/MP_0011270 decreased excitatory postsynaptic current amplitude http://purl.obolibrary.org/obo/MP_0011267 abnormal excitatory postsynaptic current amplitude reduction in the size (height or maximum displacement) of the evoked excitatory postsynaptic current wave http://purl.obolibrary.org/obo/MP_0011271 prolonged excitatory postsynaptic current rise time http://purl.obolibrary.org/obo/MP_0002910 abnormal excitatory postsynaptic currents an increase in the time required for a signal to change from resting to the peak amplitude value in the evoked excitatory postsynaptic current wave http://purl.obolibrary.org/obo/MP_0011272 short excitatory postsynaptic current rise time http://purl.obolibrary.org/obo/MP_0002910 abnormal excitatory postsynaptic currents an decrease in the time required for a signal to change from resting to the peak amplitude value in the evoked excitatory postsynaptic current wave http://purl.obolibrary.org/obo/MP_0011275 abnormal behavioral response to light http://purl.obolibrary.org/obo/MP_0004924 abnormal behavior unexpected change in the activity of an organism (in terms of movement, outward responses) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light http://purl.obolibrary.org/obo/MP_0011276 increased tail pigmentation http://purl.obolibrary.org/obo/MP_0005174 abnormal tail pigmentation visually detectable excess of pigment present on the tail surface http://purl.obolibrary.org/obo/MP_0011277 decreased tail pigmentation http://purl.obolibrary.org/obo/MP_0005408 hypopigmentation visually detectable dilution of pigment present on the tail surface http://purl.obolibrary.org/obo/MP_0011278 increased ear pigmentation http://purl.obolibrary.org/obo/MP_0001188 hyperpigmentation visually detectable excess of pigment present in the outer ear http://purl.obolibrary.org/obo/MP_0011279 decreased ear pigmentation http://purl.obolibrary.org/obo/MP_0005408 hypopigmentation visually detectable dilution of pigment present in the outer ear http://purl.obolibrary.org/obo/MP_0011280 abnormal flank coat pigmentation http://purl.obolibrary.org/obo/MP_0002075 abnormal coat/hair pigmentation irregular or unusual pigmentation of the hair between the last rib and the hip http://purl.obolibrary.org/obo/MP_0011281 abnormal olfactory epithelium cilium morphology http://purl.obolibrary.org/obo/MP_0013205 abnormal nonmotile primary cilium morphology any structural anomaly of the cilia of the epithelial cells that line the interior of the nose http://purl.obolibrary.org/obo/MP_0011282 increased podocyte apoptosis http://purl.obolibrary.org/obo/MP_0011368 increased kidney apoptosis increase in the number of podocytes undergoing programmed cell death; podocyte apoptosis is an early step in the pathophysiological progression to proteinuria and glomerulosclerosis http://purl.obolibrary.org/obo/MP_0011283 abnormal erythropoietin level http://purl.obolibrary.org/obo/MP_0003953 abnormal hormone level anomalous fluid or tissue concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine http://purl.obolibrary.org/obo/MP_0011284 abnormal circulating erythropoietin level http://purl.obolibrary.org/obo/MP_0011283 abnormal erythropoietin level anomalous blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine http://purl.obolibrary.org/obo/MP_0011285 increased circulating erythropoietin level http://purl.obolibrary.org/obo/MP_0011287 increased erythropoietin level greater blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine http://purl.obolibrary.org/obo/MP_0011286 decreased circulating erythropoietin level http://purl.obolibrary.org/obo/MP_0011288 decreased erythropoietin level reduced blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine http://purl.obolibrary.org/obo/MP_0011287 increased erythropoietin level http://purl.obolibrary.org/obo/MP_0011283 abnormal erythropoietin level greater fluid or tissue concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine http://purl.obolibrary.org/obo/MP_0011288 decreased erythropoietin level http://purl.obolibrary.org/obo/MP_0011283 abnormal erythropoietin level reduced fluid or tissue concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine http://purl.obolibrary.org/obo/MP_0011289 abnormal nephron number http://purl.obolibrary.org/obo/MP_0003881 abnormal nephron morphology anomaly in the total number of the filtering units of the kidney; nephron number can be used as an index of the efficiency of ureteric branching and nephrogenesis http://purl.obolibrary.org/obo/MP_0011290 decreased nephron number http://purl.obolibrary.org/obo/MP_0011289 abnormal nephron number reduction in the total number of filtering units of the kidney http://purl.obolibrary.org/obo/MP_0011291 nephron necrosis http://purl.obolibrary.org/obo/MP_0003881 abnormal nephron morphology morphological changes resulting from pathological death of nephron tissue; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0011292 absent nephron http://purl.obolibrary.org/obo/MP_0003881 abnormal nephron morphology complete absence of functional filtering units in the kidney http://purl.obolibrary.org/obo/MP_0011293 dilated nephron http://purl.obolibrary.org/obo/MP_0003881 abnormal nephron morphology stretched or widened aperture of the luminal space of the filtering unit of the kidney http://purl.obolibrary.org/obo/MP_0011294 renal glomerulus hypertrophy http://purl.obolibrary.org/obo/MP_0005325 abnormal renal glomerulus morphology increase in the bulk size of the capillary loops of the kidney that normally function as a filtration unit, due to cell enlargement http://purl.obolibrary.org/obo/MP_0011295 abnormal tubuloglomerular feedback response http://purl.obolibrary.org/obo/MP_0002136 abnormal kidney physiology any anomaly in the blood flow control mechanism that is operated in the juxtaglomerular apparatus of the kidney and involved in renal autoregulation by limiting changes in the glomerular filtration rate. TGF responds to changes in the concentration of NaCl in the tubular fluid at the level of the macula densa http://purl.obolibrary.org/obo/MP_0011296 decreased tubuloglomerular feedback response http://purl.obolibrary.org/obo/MP_0011295 abnormal tubuloglomerular feedback response attenuation of the blood flow control mechanism that is operated in the juxtaglomerular apparatus of the kidney and involved in renal autoregulation by limiting changes in the glomerular filtration rate. TGF responds to changes in the concentration of NaCl in the tubular fluid at the level of the macula densa http://purl.obolibrary.org/obo/MP_0011297 absent tubuloglomerular feedback response http://purl.obolibrary.org/obo/MP_0011295 abnormal tubuloglomerular feedback response absence of the blood flow control mechanism that is operated in the juxtaglomerular apparatus of the kidney and involved in renal autoregulation by limiting changes in the glomerular filtration rate. TGF responds to changes in the concentration of NaCl in the tubular fluid at the level of the macula densa http://purl.obolibrary.org/obo/MP_0011298 ureter hypoplasia http://purl.obolibrary.org/obo/MP_0000534 abnormal ureter morphology underdevelopment or reduced size of the ureter, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0011299 abnormal macula densa morphology http://purl.obolibrary.org/obo/MP_0004757 abnormal distal convoluted tubule morphology any structural anomaly of the specialized group of densely packed epithelial cells marking the origin of the convoluted portion of the distal tubule of a nephron, in contact with the afferent arteriole of the renal corpuscle and contiguous with the juxtaglomerular cells; these cells are tall, thin and columnar, have prominent nuclei, and act as sensors of solute concentration and flow of tubular fluid http://purl.obolibrary.org/obo/MP_0011300 abnormal juxtaglomerular cell morphology http://purl.obolibrary.org/obo/MP_0002829 abnormal juxtaglomerular apparatus morphology any structural anomaly of the specialized smooth muscle cells that synthesize, store, and secrete renin and are found in the wall of each afferent arteriole of a kidney glomerulus near its point of entry adjacent to a macula densa; J-G cells are distinguished by their granulated cytoplasm and play a critical role in the renin-angiotensin system and thus in renal autoregulation http://purl.obolibrary.org/obo/MP_0011301 juxtaglomerular cell hyperplasia http://purl.obolibrary.org/obo/MP_0011300 abnormal juxtaglomerular cell morphology increased number of the specialized smooth muscle cells that synthesize, store, and secrete renin and are found in the wall of each afferent arteriole of a kidney glomerulus near its point of entry adjacent to a macula densa http://purl.obolibrary.org/obo/MP_0011302 abnormal extraglomerular mesangial cell morphology http://purl.obolibrary.org/obo/MP_0011340 abnormal extraglomerular mesangium morphology any structural anomaly of the light-staining cells in the kidney found outside the glomerulus, near the vascular pole and macula densa; lacis cells form the juxtaglomerular apparatus in combination with two other types of cells: the macula densa of the distal convoluted tubule and juxtaglomerular cells of the afferent arteriole http://purl.obolibrary.org/obo/MP_0011303 absent kidney papilla http://purl.obolibrary.org/obo/MP_0004193 abnormal kidney papilla morphology absence of the apex (tip) of a renal pyramid i.e. the location where each medullary pyramid empties urine into a minor calyx http://purl.obolibrary.org/obo/MP_0011304 kidney papillary atrophy http://purl.obolibrary.org/obo/MP_0004193 abnormal kidney papilla morphology acquired diminution of the size of the apex (tip) of a renal pyramid associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0011305 dilated kidney calyx http://purl.obolibrary.org/obo/MP_0004195 abnormal kidney calyx morphology an expansion in the lumen volume or area of any of the branches of the renal pelvis that surround each renal papilla and collect urine http://purl.obolibrary.org/obo/MP_0011306 absent kidney pelvis http://purl.obolibrary.org/obo/MP_0004194 abnormal kidney pelvis morphology absence of the funnel shaped proximal portion of the ureter, normally formed by convergence of the major calices http://purl.obolibrary.org/obo/MP_0011307 kidney medulla cysts http://purl.obolibrary.org/obo/MP_0003675 kidney cysts abnormal membranous sacs appearing in the inner portion of the kidney which consists of the renal pyramids http://purl.obolibrary.org/obo/MP_0011308 kidney corticomedullary cysts http://purl.obolibrary.org/obo/MP_0003675 kidney cysts development of abnormal membranous sacs in the corticomedullary junction of the kidney http://purl.obolibrary.org/obo/MP_0011309 abnormal kidney arterial blood vessel morphology http://purl.obolibrary.org/obo/MP_0011655 abnormal systemic artery morphology any structural anomaly of the network of tubes that supply blood to the renal tissues http://purl.obolibrary.org/obo/MP_0011310 abnormal kidney capillary morphology http://purl.obolibrary.org/obo/MP_0003658 abnormal capillary morphology any structural anomaly of the small branching blood vessels in the kidney that form a network between the arterioles and venules, where the exchange of water, oxygen, carbon dioxide, and other nutrient and waste chemical substances occurs between the blood and the surrounding tissues http://purl.obolibrary.org/obo/MP_0011311 abnormal kidney venous blood vessel morphology http://purl.obolibrary.org/obo/MP_0002725 abnormal vein morphology any structural anomaly of the network of tubes that return blood from the renal tissues to the systemic circulation http://purl.obolibrary.org/obo/MP_0011312 abnormal kidney afferent arteriole morphology http://purl.obolibrary.org/obo/MP_0011309 abnormal kidney arterial blood vessel morphology any structural anomaly of the blood vessels that branch from the kidney interlobular artery, convey blood to the glomerular capillaries, and play an important role in the regulation of blood pressure as a part of the tubuloglomerular feedback mechanism http://purl.obolibrary.org/obo/MP_0011313 abnormal kidney efferent arteriole morphology http://purl.obolibrary.org/obo/MP_0011309 abnormal kidney arterial blood vessel morphology any structural anomaly of the blood vessels that convey blood from the glomerulocapillary network to the capillary bed of the proximal convoluted tubule http://purl.obolibrary.org/obo/MP_0011314 abnormal kidney cortex artery morphology http://purl.obolibrary.org/obo/MP_0011309 abnormal kidney arterial blood vessel morphology any structural anomaly of the network of tubes that supplies blood to the renal cortex http://purl.obolibrary.org/obo/MP_0011315 abnormal kidney arcuate artery morphology http://purl.obolibrary.org/obo/MP_0011314 abnormal kidney cortex artery morphology any structural anomaly of the curved arteries at the corticomedullary border of the kidney that arise from the interlobar arteries and give rise to the interlobular arteries http://purl.obolibrary.org/obo/MP_0011316 abnormal kidney interlobular artery morphology http://purl.obolibrary.org/obo/MP_0011314 abnormal kidney cortex artery morphology any structural anomaly of the branches of the arcuate arteries of the kidney that radiate outward throught the renal columns and supply the glomeruli http://purl.obolibrary.org/obo/MP_0011317 abnormal renal artery morphology http://purl.obolibrary.org/obo/MP_0011309 abnormal kidney arterial blood vessel morphology any structural anomaly of the pair of major vessels which arise off the side of the abdominal aorta, immediately below the superior mesenteric artery, and supply the kidneys with blood; small branches of the renal artery also supply the suprarenal gland, the ureter and some surrounding tissues http://purl.obolibrary.org/obo/MP_0011318 abnormal right renal artery morphology http://purl.obolibrary.org/obo/MP_0011317 abnormal renal artery morphology any structural anomaly of the major vessel which arises off the side of the abdominal aorta, immediately below the superior mesenteric artery, and supplies the right kidney with blood http://purl.obolibrary.org/obo/MP_0011319 abnormal left renal artery morphology http://purl.obolibrary.org/obo/MP_0011317 abnormal renal artery morphology any structural anomaly of the major vessel which arises off the side of the abdominal aorta, immediately below the superior mesenteric artery, and supplies the left kidney with blood http://purl.obolibrary.org/obo/MP_0011320 abnormal glomerular capillary morphology http://purl.obolibrary.org/obo/MP_0011310 abnormal kidney capillary morphology any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus http://purl.obolibrary.org/obo/MP_0011321 abnormal peritubular capillary morphology http://purl.obolibrary.org/obo/MP_0011310 abnormal kidney capillary morphology any structural anomaly of the tiny blood vessels that receive blood from the efferent arterioles of the glomerulus, and interact with superficial cortical nephrons allowing reabsorption and secretion between blood and the inner lumen of the nephron; peritubular capillaries are situated around the tubule and are at low pressure http://purl.obolibrary.org/obo/MP_0011322 abnormal kidney cortex vein morphology http://purl.obolibrary.org/obo/MP_0011311 abnormal kidney venous blood vessel morphology any structural anomaly of the network of tubes that receives blood from the renal cortex http://purl.obolibrary.org/obo/MP_0011323 abnormal renal vein morphology http://purl.obolibrary.org/obo/MP_0011311 abnormal kidney venous blood vessel morphology any structural anomaly of the pair of major vessels which arise from the renal hilus and return blood from the kidneys, suprarenal gland and the ureter to the inferior vena cava http://purl.obolibrary.org/obo/MP_0011325 abnormal kidney arcuate vein morphology http://purl.obolibrary.org/obo/MP_0011322 abnormal kidney cortex vein morphology any structural anomaly of the veins that parallel the arcuate arteries, receive blood from the interlobular veins and straight venules, and terminate in the interlobar veins http://purl.obolibrary.org/obo/MP_0011326 abnormal interlobular vein morphology http://purl.obolibrary.org/obo/MP_0011322 abnormal kidney cortex vein morphology any structural anomaly of the veins that parallel the interlobular arteries, receiving blood from the peritubular capillary plexus and empty into the arcuate veins http://purl.obolibrary.org/obo/MP_0011327 abnormal left renal vein morphology http://purl.obolibrary.org/obo/MP_0011323 abnormal renal vein morphology any structural anomaly of the longer of the two renal veins that receives blood from the left kidney; the left renal vein usually receives the left inferior phrenic vein, the left suprarenal vein, the left gonadal vein (left testicular vein in males, left ovarian vein in females) and the left second lumbar vein whereas these veins on the right side drain directly into the inferior vena cava http://purl.obolibrary.org/obo/MP_0011328 abnormal right renal vein morphology http://purl.obolibrary.org/obo/MP_0011323 abnormal renal vein morphology any structural anomaly of the shorter of the two renal veins that receives blood from the right kidney; the left renal vein usually receives the left inferior phrenic vein, the left suprarenal vein, the left gonadal vein (left testicular vein in males, left ovarian vein in females) and the left second lumbar vein whereas these veins on the right side drain directly into the inferior vena cava http://purl.obolibrary.org/obo/MP_0011331 abnormal papillary duct morphology http://purl.obolibrary.org/obo/MP_0004754 abnormal kidney collecting duct morphology any structural anomaly of the largest straight excretory ducts in the kidney medulla and papillae that are a continuation of the collecting tubules, and that open into the area cribosa http://purl.obolibrary.org/obo/MP_0011332 abnormal kidney outer medulla morphology http://purl.obolibrary.org/obo/MP_0003014 abnormal kidney medulla morphology any structural anomaly of the outer medullary region of the adult kidney containing the short Loops of Henle and collecting ducts http://purl.obolibrary.org/obo/MP_0011334 abnormal nephrogenic zone morphology http://purl.obolibrary.org/obo/MP_0000527 abnormal kidney development any structural anomaly in the region found at the periphery of the developing metanephros within which the metanephric mesenchyme aggregates around the tips of the ureteric tree to form the nephrons; in rodents including mice, this region normally disappears within the first postnatal week when nephrogenesis ceases and only mature nephrons are present; in humans, it is lost by 36 weeks of gestation http://purl.obolibrary.org/obo/MP_0011335 abnormal kidney pelvis smooth muscle morphology http://purl.obolibrary.org/obo/MP_0011426 abnormal ureter smooth muscle morphology any structural anomaly of the smooth muscle tissue surrounding the urothelium of the kidney pelvis http://purl.obolibrary.org/obo/MP_0011336 abnormal kidney pelvis urothelium morphology http://purl.obolibrary.org/obo/MP_0004194 abnormal kidney pelvis morphology any structural anomaly of the epithelial lining of the luminal space of the kidney pelvis http://purl.obolibrary.org/obo/MP_0011337 abnormal perihilar interstitium morphology http://purl.obolibrary.org/obo/MP_0011425 abnormal kidney interstitium morphology any structural anomaly of the part of the renal interstitium surrounding the pelvis http://purl.obolibrary.org/obo/MP_0011338 abnormal mesangial matrix morphology http://purl.obolibrary.org/obo/MP_0011339 abnormal glomerular mesangium morphology any structural anomaly of the extracellular matrix secreted by intraglomerular mesangial cells http://purl.obolibrary.org/obo/MP_0011339 abnormal glomerular mesangium morphology http://purl.obolibrary.org/obo/MP_0005325 abnormal renal glomerulus morphology any structural anomaly of the inner layer of the glomerulus within the basement membrane surrounding the glomerular capillaries that contain the intraglomerular mesangial cells http://purl.obolibrary.org/obo/MP_0011340 abnormal extraglomerular mesangium morphology http://purl.obolibrary.org/obo/MP_0002827 abnormal renal corpuscle morphology any structural anomaly of the tissue comprised of mesangial cells that fill the triangular space between the macula densa and the afferent and efferent arterioles of the juxtaglomerular apparatus http://purl.obolibrary.org/obo/MP_0011341 abnormal loop of Henle descending limb morphology http://purl.obolibrary.org/obo/MP_0004755 abnormal loop of Henle morphology any structural anomaly of the portion of the renal tubule that constitutes the proximal part of the loop of Henle, has low permeability to ions and urea, and is highly permeable to water; it consists of an initial short thick segment lined by low simple cuboidal epithelium and a long thin segment lined by simple squamous epithelium; however, this distinction is not as important physiologically as in the ascending limb, so often the two are treated as one structure http://purl.obolibrary.org/obo/MP_0011342 abnormal loop of Henle ascending limb morphology http://purl.obolibrary.org/obo/MP_0004755 abnormal loop of Henle morphology any structural anomaly of the distal part of the loop of Henle that is impermeable to water and actively pumps sodium out of the filtrate to generate the hypertonic interstitium that drives countercurrent exchange; it consists of an initial very thin segment lined by simple squamous epithelium followed by a distal thick segment lined by simple cuboidal epithelium http://purl.obolibrary.org/obo/MP_0011343 abnormal loop of Henle ascending limb thin segment morphology http://purl.obolibrary.org/obo/MP_0011342 abnormal loop of Henle ascending limb morphology any structural anomaly of the initial sub-portion of the ascending loop of Henle localized in the juxtamedullary nephron of the kidney; it is lined by simple squamous epithelium, impermeable to water but permeable to ions and other small particles http://purl.obolibrary.org/obo/MP_0011344 abnormal loop of Henle ascending limb thick segment morphology http://purl.obolibrary.org/obo/MP_0011342 abnormal loop of Henle ascending limb morphology any structural anomaly of the distal sub-portion of the ascending loop of Henle which is lined by simple cuboidal epithelium and enters the renal cortex to empty a hypotonic filtrate into the distal convoluted tubule http://purl.obolibrary.org/obo/MP_0011345 truncated loop of Henle http://purl.obolibrary.org/obo/MP_0004755 abnormal loop of Henle morphology failure of the developing loop of Henle to elongate and extend into the medullary zone of the kidney http://purl.obolibrary.org/obo/MP_0011346 renal tubule atrophy http://purl.obolibrary.org/obo/MP_0004970 kidney atrophy acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0011347 abnormal kidney medullary ray morphology http://purl.obolibrary.org/obo/MP_0000521 abnormal kidney cortex morphology any structural anomaly in the center of a renal, cortical lobule, consisting of the ascending or descending limbs of the loop of Henle or of the collecting tubules; medullary rays are regions where parallel arrays of straight tubules travel perpendicular to the capsule and extend from the cortex to the medulla http://purl.obolibrary.org/obo/MP_0011348 abnormal renal glomerulus basement membrane morphology http://purl.obolibrary.org/obo/MP_0002827 abnormal renal corpuscle morphology any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter http://purl.obolibrary.org/obo/MP_0011349 abnormal renal glomerulus basement membrane thickness http://purl.obolibrary.org/obo/MP_0011348 abnormal renal glomerulus basement membrane morphology increased or decreased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule http://purl.obolibrary.org/obo/MP_0011350 abnormal proximal convoluted tubule brush border morphology http://purl.obolibrary.org/obo/MP_0004756 abnormal proximal convoluted tubule morphology any structural anomaly of the densely packed microvilli that cover the luminal surface of epithelial cells of the proximal convoluted tubule; microvilli increase the luminal surface area of cells, sense the fluid flow in the tubule lumen and convert this information via biochemical responses into reabsorption http://purl.obolibrary.org/obo/MP_0011351 absent proximal convoluted tubule brush border http://purl.obolibrary.org/obo/MP_0011350 abnormal proximal convoluted tubule brush border morphology failure to form a brush border of densely packed microvilli on the luminal surface of epithelial cells of the proximal convoluted tubule http://purl.obolibrary.org/obo/MP_0011352 proximal convoluted tubule brush border loss http://purl.obolibrary.org/obo/MP_0011350 abnormal proximal convoluted tubule brush border morphology attenuation or degeneration of the microvillus brush border normally present on the luminal surface of epithelial cells of the proximal convoluted tubule; may be associated with renal tubular injury and/or cystic changes http://purl.obolibrary.org/obo/MP_0011353 expanded mesangial matrix http://purl.obolibrary.org/obo/MP_0011338 abnormal mesangial matrix morphology increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells http://purl.obolibrary.org/obo/MP_0011354 absent renal glomerulus http://purl.obolibrary.org/obo/MP_0005325 abnormal renal glomerulus morphology complete absence of the tuft formed of capillary loops and mesangium at the beginning of each nephretic tubule in the kidney that normally function as a filtration unit http://purl.obolibrary.org/obo/MP_0011355 abnormal kidney interlobar artery morphology http://purl.obolibrary.org/obo/MP_0011309 abnormal kidney arterial blood vessel morphology any structural anomaly of the branches of the segmental arteries of the kidney that cross between the renal lobes and give rise to the arculate arteries in the cortex http://purl.obolibrary.org/obo/MP_0011356 renal artery stenosis http://purl.obolibrary.org/obo/MP_0011317 abnormal renal artery morphology diffuse constriction or narrowing of one or both renal arteries http://purl.obolibrary.org/obo/MP_0011357 supernumerary renal arteries http://purl.obolibrary.org/obo/MP_0011317 abnormal renal artery morphology two or more arteries branch from the abdominal aorta and supply a single kidney http://purl.obolibrary.org/obo/MP_0011358 renal artery aneurysm http://purl.obolibrary.org/obo/MP_0011317 abnormal renal artery morphology a protruding sac formed by the dilation of the wall of a renal artery, resulting from a weakening of the vessel wall or heart muscle http://purl.obolibrary.org/obo/MP_0011359 decreased glomerular capillary number http://purl.obolibrary.org/obo/MP_0011320 abnormal glomerular capillary morphology reduced number of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles http://purl.obolibrary.org/obo/MP_0011360 kidney cortex hypoplasia http://purl.obolibrary.org/obo/MP_0000521 abnormal kidney cortex morphology underdevelopment or reduced size, usually due to a reduced number of cells, of the outer portion of the kidney, which contains the renal corpuscles, the renal tubules (except for parts of the loop of Henle which descend into the renal medulla), blood vessels and cortical collecting ducts http://purl.obolibrary.org/obo/MP_0011361 pelvic kidney http://purl.obolibrary.org/obo/MP_0003600 ectopic kidney an ectopic kidney located outside the renal fossa and within the pelvic cavity; pelvic kidneys may also, on occasion, occur as fused midline horseshoe kidneys http://purl.obolibrary.org/obo/MP_0011362 ectopic adrenal gland http://purl.obolibrary.org/obo/MP_0000639 abnormal adrenal gland morphology an adrenal gland located outside of its normal position http://purl.obolibrary.org/obo/MP_0011363 renal glomerulus atrophy http://purl.obolibrary.org/obo/MP_0004970 kidney atrophy acquired diminution of the size of the capillary loops of the kidney associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0011364 abnormal metanephros morphology http://purl.obolibrary.org/obo/MP_0000527 abnormal kidney development any structural anomaly of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord; the metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine http://purl.obolibrary.org/obo/MP_0011365 small metanephros http://purl.obolibrary.org/obo/MP_0011364 abnormal metanephros morphology reduced size of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord http://purl.obolibrary.org/obo/MP_0011366 absent metanephros http://purl.obolibrary.org/obo/MP_0011364 abnormal metanephros morphology absence of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord http://purl.obolibrary.org/obo/MP_0011367 abnormal kidney apoptosis http://purl.obolibrary.org/obo/MP_0002136 abnormal kidney physiology change in the timing or the number of kidney cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0011369 increased renal glomerulus apoptosis http://purl.obolibrary.org/obo/MP_0011368 increased kidney apoptosis increase in the number of cells of the kidney glomerulus undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0011370 increased mesangial cell apoptosis http://purl.obolibrary.org/obo/MP_0011368 increased kidney apoptosis increase in the number of phagocytic cells in the capillary tuft of the renal glomerulus undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0011371 decreased kidney apoptosis http://purl.obolibrary.org/obo/MP_0011367 abnormal kidney apoptosis decrease in the number of cells of the kidney undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0011372 decreased renal tubule apoptosis http://purl.obolibrary.org/obo/MP_0011371 decreased kidney apoptosis decrease in the number of renal tubule cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0011373 decreased mesangial cell apoptosis http://purl.obolibrary.org/obo/MP_0011371 decreased kidney apoptosis decrease in the number of phagocytic cells in the capillary tuft of the renal glomerulus undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0011374 decreased podocyte apoptosis http://purl.obolibrary.org/obo/MP_0011371 decreased kidney apoptosis decrease in the number of podocytes undergoing programmed cell death; podocyte apoptosis is an early step in the pathophysiological progression to proteinuria and glomerulosclerosis http://purl.obolibrary.org/obo/MP_0011375 decreased renal glomerulus apoptosis http://purl.obolibrary.org/obo/MP_0011371 decreased kidney apoptosis decrease in the number of cells of the kidney glomerulus undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0011376 abnormal kidney corticomedullary boundary morphology http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology any structural anomaly of the region demarcating the renal medulla from the surrounding cortex; end-stage renal failure may be associated with loss of the normal corticomedullary boundary http://purl.obolibrary.org/obo/MP_0011377 renal glomerulus fibrosis http://purl.obolibrary.org/obo/MP_0005325 abnormal renal glomerulus morphology formation of fibrous tissue in the renal glomerulus as a result of repair or a reactive process http://purl.obolibrary.org/obo/MP_0011378 abnormal kidney outer medulla inner stripe morphology http://purl.obolibrary.org/obo/MP_0011332 abnormal kidney outer medulla morphology any structural anomaly of the deep, centrally located portion of the renal outer medulla that is traversed by thin descending and thick ascending portions of the loops of Henle http://purl.obolibrary.org/obo/MP_0011379 abnormal kidney outer medulla outer stripe morphology http://purl.obolibrary.org/obo/MP_0011332 abnormal kidney outer medulla morphology any structural anomaly of the region of the kidney outer medulla that lies just below the cortex; the proximal straight tubules are present in this region http://purl.obolibrary.org/obo/MP_0011380 enlarged brain ventricles http://purl.obolibrary.org/obo/MP_0013229 abnormal brain ventricle size increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord http://purl.obolibrary.org/obo/MP_0011381 abnormal kidney lobe morphology http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology any structural anomaly of the portion of a kidney consisting of a renal medullary pyramid and the renal cortex above it; human kidneys have multilobar (multipyramidal) architecture while mice and rats have unilobar (unipyramidal) kidneys http://purl.obolibrary.org/obo/MP_0011382 abnormal kidney lobule morphology http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology any structural anomaly of the portion of a renal lobe consisting of nephrons grouped around a single medullary ray and draining into a single collecting duct; human kidneys have multilobular, multipapillary architecture while mice and rats have unilobular, unipapillary kidneys http://purl.obolibrary.org/obo/MP_0011383 abnormal kidney capsule morphology http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology any structural anomaly of the tough fibrous layer surrounding the kidney which is covered in a thick layer of perirenal adipose tissue that functions to provide some protection from trauma and damage http://purl.obolibrary.org/obo/MP_0011384 abnormal progesterone level http://purl.obolibrary.org/obo/MP_0003953 abnormal hormone level anomaly in the concentration of the antiestrogenic steroid released by the corpus luteum that stimulates the uterus to prepare for pregnancy http://purl.obolibrary.org/obo/MP_0011385 abnormal testosterone level http://purl.obolibrary.org/obo/MP_0003953 abnormal hormone level anomaly in the concentration of a potent androgen that promotes development of male secondary sex characteristics and the development of spermatozoa and may regulate sexual desire and help maintain bone and muscle health in both males and females http://purl.obolibrary.org/obo/MP_0011386 increased metanephric mesenchyme apoptosis http://purl.obolibrary.org/obo/MP_0010984 abnormal metanephric mesenchyme morphology increase in the number of cells of the metanephric mesenchyme (MM) undergoing programmed cell death; usually due to failure of MM cells to interact with the ureteric bud (UB) tips after UB invasion http://purl.obolibrary.org/obo/MP_0011387 absent metanephric mesenchyme http://purl.obolibrary.org/obo/MP_0010984 abnormal metanephric mesenchyme morphology absence of the embryonic connective tissue made up of loosely aggregated mesenchymal cells, supported by interlaminar jelly, that gives rise to the developing metanephros; normally, interactions between the ureteric bud and the metanephric mesenchyme lead to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue http://purl.obolibrary.org/obo/MP_0011388 absent heart http://purl.obolibrary.org/obo/MP_0000266 abnormal heart morphology absence of the hollow, muscular organ that maintains the circulation of the blood http://purl.obolibrary.org/obo/MP_0011389 absent optic disc http://purl.obolibrary.org/obo/MP_0008259 abnormal optic disc morphology absence of the area in the retina where all of the axons of the ganglion cells exit the retina to form the optic nerve http://purl.obolibrary.org/obo/MP_0011391 abnormal fetal cardiomyocyte apoptosis http://purl.obolibrary.org/obo/MP_0011390 abnormal fetal cardiomyocyte physiology change in the timing or the number of fetal cardiomyocytes undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0011392 increased fetal cardiomyocyte apoptosis http://purl.obolibrary.org/obo/MP_0011391 abnormal fetal cardiomyocyte apoptosis increase in the number of fetal cardiomyocytes undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0011393 decreased fetal cardiomyocyte apoptosis http://purl.obolibrary.org/obo/MP_0011391 abnormal fetal cardiomyocyte apoptosis reduction in the number of fetal cardiomyocytes undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0011394 increased fetal cardiomyocyte proliferation http://purl.obolibrary.org/obo/MP_0003567 abnormal fetal cardiomyocyte proliferation increase in the ability of the differentiating cardiac muscle cell population to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0011395 decreased fetal cardiomyocyte proliferation http://purl.obolibrary.org/obo/MP_0003567 abnormal fetal cardiomyocyte proliferation reduced ability of the differentiating cardiac muscle cell population to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0011397 endoneurial edema http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology an excessive accumulation of serous fluid in the interstitial connective tissue of a peripheral nerve http://purl.obolibrary.org/obo/MP_0011398 abnormal endoneurial fluid pressure http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology measureable anomalies in the fluid of the ganglia and peripheral nerves that lie outside the brain and spinal cord which may interfere with normal nerve physiology http://purl.obolibrary.org/obo/MP_0011399 increased endoneurial fluid pressure http://purl.obolibrary.org/obo/MP_0011398 abnormal endoneurial fluid pressure a measureable increase of serous fluid in the interstitial connective tissue of a peripheral nerve which may interefere with normal nerve physiology http://purl.obolibrary.org/obo/MP_0011400 complete lethality http://purl.obolibrary.org/obo/MP_0010769 abnormal survival all individuals of a given genotype in a population die before the end of the normal lifespan but time(s) of death are unspecified http://purl.obolibrary.org/obo/MP_0011401 abnormal vascular smooth muscle development http://purl.obolibrary.org/obo/MP_0005592 abnormal vascular smooth muscle morphology anomaly in the process of forming the nonstriated, involuntary muscle tissue of the blood vessels http://purl.obolibrary.org/obo/MP_0011402 renal cast http://purl.obolibrary.org/obo/MP_0003881 abnormal nephron morphology any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts) http://purl.obolibrary.org/obo/MP_0011403 pyelonephritis http://purl.obolibrary.org/obo/MP_0001859 kidney inflammation a diffuse pyogenic infection of the pelvis and parenchyma of the kidney; an ascending urinary tract infection that has reached the pyelum or pelvis of the kidney usually resulting from noncontagious bacterial infection of the bladder http://purl.obolibrary.org/obo/MP_0011404 pyelitis http://purl.obolibrary.org/obo/MP_0001859 kidney inflammation acute inflammation of the pelvis of the kidney, caused by bacterial infection http://purl.obolibrary.org/obo/MP_0011405 tubulointerstitial nephritis http://purl.obolibrary.org/obo/MP_0001859 kidney inflammation diffuse or local inflammation and edema of the interstitial tissue of the kidney, including the renal tubules; usually secondary to drug sensitization, systemic infection, graft rejection, or autoimmune disease http://purl.obolibrary.org/obo/MP_0011406 abnormal retrotrapezoid nucleus morphology http://purl.obolibrary.org/obo/MP_0000846 abnormal medulla oblongata morphology any structural anomaly in the loose collection of neurons that reside in the rostral medulla close to the medullary surface, ventral and immediately caudal of nVII, that are crucial for CO2 sensing in the brain http://purl.obolibrary.org/obo/MP_0011407 absent nephrogenic zone http://purl.obolibrary.org/obo/MP_0011334 abnormal nephrogenic zone morphology absence of the region found at the periphery of the developing metanephros within which the metanephric mesenchyme aggregates around the tips of the ureteric tree to form the nephrons;in rodents including mice, this region normally persists for a few days postnatally, although it is lost in humans by 36 weeks of gestation http://purl.obolibrary.org/obo/MP_0011408 renal tubule hypertrophy http://purl.obolibrary.org/obo/MP_0002703 abnormal renal tubule morphology increase in the bulk size of the loop of Henle, the proximal convoluted tubule or the distal convoluted tubule, due to cell enlargement http://purl.obolibrary.org/obo/MP_0011409 increased renal glomerulus basement membrane thickness http://purl.obolibrary.org/obo/MP_0011349 abnormal renal glomerulus basement membrane thickness increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule http://purl.obolibrary.org/obo/MP_0011410 ectopic testis http://purl.obolibrary.org/obo/MP_0001146 abnormal testis morphology one or both of the testes located outside the normal pathway of descent into the scrotum http://purl.obolibrary.org/obo/MP_0011411 abnormal gonadal ridge morphology http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology any structural anomaly of the elevation of thickened mesothelium and underlying mesenchyme found on the ventromedial border of the embryonic mesonephros in which the primordial germ cells become embedded, establishing it as the primordium of the testis or ovary http://purl.obolibrary.org/obo/MP_0011412 gonadal ridge hypoplasia http://purl.obolibrary.org/obo/MP_0011411 abnormal gonadal ridge morphology underdevelopment or reduced size of the elevation of thickened mesothelium and underlying mesenchyme found on the ventromedial border of the embryonic mesonephros, usually due to reduced cell number; normally, primordial germ cells become embedded in it, establishing it as the primordium of the testis or ovary http://purl.obolibrary.org/obo/MP_0011413 colorless urine http://purl.obolibrary.org/obo/MP_0003619 abnormal urine color absence of the usual straw-coloration of the urine http://purl.obolibrary.org/obo/MP_0011414 erythruria http://purl.obolibrary.org/obo/MP_0003619 abnormal urine color passage of red colored urine http://purl.obolibrary.org/obo/MP_0011415 abnormal aldosterone level http://purl.obolibrary.org/obo/MP_0003953 abnormal hormone level anomaly in the concentration of the hormone that is secreted by the adrenal cortex and regulates sodium conservation and potassium secretion in the distal renal tubule http://purl.obolibrary.org/obo/MP_0011416 abnormal testis interstitial tissue morphology http://purl.obolibrary.org/obo/MP_0001146 abnormal testis morphology any structural anomaly of the delicate connective tissue stroma that separates the seminiferous tubules and contains clusters of endocrine Leydig cells which secrete testosterone http://purl.obolibrary.org/obo/MP_0011417 abnormal renal transport http://purl.obolibrary.org/obo/MP_0002136 abnormal kidney physiology any anomaly of the directed movement of substances through the kidney http://purl.obolibrary.org/obo/MP_0011418 leukocyturia http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis presence of white blood cells in the urine http://purl.obolibrary.org/obo/MP_0011419 erythrocyturia http://purl.obolibrary.org/obo/MP_0005161 hematuria presence of red blood cells in the urine http://purl.obolibrary.org/obo/MP_0011420 pyuria http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis presence of pus in the urine when voided; a sign of inflammation often related to urinary tract infection http://purl.obolibrary.org/obo/MP_0011421 cylindruria http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis presence of renal cylinders or casts in the urine http://purl.obolibrary.org/obo/MP_0011422 kidney medulla atrophy http://purl.obolibrary.org/obo/MP_0004970 kidney atrophy acquired diminution of the size of the inner portion of the kidney consisting of the renal pyramids, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0011423 kidney cortex atrophy http://purl.obolibrary.org/obo/MP_0004970 kidney atrophy acquired diminution of the size of the outer portion of the kidney located between the renal capsule and the renal medulla, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0011424 decreased urine uric acid level http://purl.obolibrary.org/obo/MP_0009809 abnormal urine uric acid level abnormally low amount in the urine of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine http://purl.obolibrary.org/obo/MP_0011426 abnormal ureter smooth muscle morphology http://purl.obolibrary.org/obo/MP_0000534 abnormal ureter morphology any structural anomaly of the smooth muscle tissue surrounding the epithelium of the ureter http://purl.obolibrary.org/obo/MP_0011427 mesangial cell hyperplasia http://purl.obolibrary.org/obo/MP_0005327 abnormal mesangial cell morphology increased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft http://purl.obolibrary.org/obo/MP_0011428 mesangial cell hypoplasia http://purl.obolibrary.org/obo/MP_0005327 abnormal mesangial cell morphology decreased number of the phagocytic cells in the capillary tuft of the renal glomerulus, interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft http://purl.obolibrary.org/obo/MP_0011429 absent mesangial cell http://purl.obolibrary.org/obo/MP_0005327 abnormal mesangial cell morphology absence of the phagocytic cells in the capillary tuft of the renal glomerulus, normally interposed between endothelial cells and the basement membrane in the central or stalk region of the tuft http://purl.obolibrary.org/obo/MP_0011430 mesangiolysis http://purl.obolibrary.org/obo/MP_0011339 abnormal glomerular mesangium morphology an injurious glomerular process that affects primarily the mesangium, starting with loosening and detachment of its matrix and progressing to dissolution/attenuation with degeneration of mesangial cells; mesangial cells may show only edema and vacuolization, or may undergo severe degeneration and necrosis http://purl.obolibrary.org/obo/MP_0011431 increased urine flow rate http://purl.obolibrary.org/obo/MP_0001756 abnormal urination increased volume of urine produced in a specified period of time http://purl.obolibrary.org/obo/MP_0011432 decreased urine flow rate http://purl.obolibrary.org/obo/MP_0001756 abnormal urination reduced volume of urine produced in a specified period of time http://purl.obolibrary.org/obo/MP_0011433 glomerular capillary congestion http://purl.obolibrary.org/obo/MP_0000532 kidney vascular congestion obstruction of the normal flux of blood within the renal glomerular capillaries http://purl.obolibrary.org/obo/MP_0011434 abnormal urine magnesium level http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis any change in the amount of magnesium in the urine http://purl.obolibrary.org/obo/MP_0011435 increased urine magnesium level http://purl.obolibrary.org/obo/MP_0011434 abnormal urine magnesium level higher than normal amount of magnesium in the urine http://purl.obolibrary.org/obo/MP_0011436 decreased urine magnesium level http://purl.obolibrary.org/obo/MP_0011434 abnormal urine magnesium level lower than normal amount of magnesium in the urine http://purl.obolibrary.org/obo/MP_0011437 glomerulus hemorrhage http://purl.obolibrary.org/obo/MP_0000533 kidney hemorrhage bleeding in the renal glomerulus http://purl.obolibrary.org/obo/MP_0011438 absent kidney medulla http://purl.obolibrary.org/obo/MP_0003014 abnormal kidney medulla morphology failure of the inner portion of the kidney, normally consisting of the renal pyramids, to form http://purl.obolibrary.org/obo/MP_0011439 abnormal kidney cell proliferation http://purl.obolibrary.org/obo/MP_0002136 abnormal kidney physiology anomaly in the ability of any kidney cell population to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0011440 increased kidney cell proliferation http://purl.obolibrary.org/obo/MP_0011439 abnormal kidney cell proliferation increase in the expansion rate of any kidney cell population by cell division http://purl.obolibrary.org/obo/MP_0011441 decreased kidney cell proliferation http://purl.obolibrary.org/obo/MP_0011439 abnormal kidney cell proliferation decrease in the expansion rate of any kidney cell population by cell division http://purl.obolibrary.org/obo/MP_0011442 abnormal renal sodium ion transport http://purl.obolibrary.org/obo/MP_0011417 abnormal renal transport any anomaly in the directed movement of sodium ions (Na+) by the kidney http://purl.obolibrary.org/obo/MP_0011443 abnormal renal water transport http://purl.obolibrary.org/obo/MP_0011444 abnormal renal water homeostasis any anomaly in the directed movement of water (H2O) by the kidney http://purl.obolibrary.org/obo/MP_0011444 abnormal renal water homeostasis http://purl.obolibrary.org/obo/MP_0002136 abnormal kidney physiology any anomaly in the kidney processes involved in the maintenance of an internal steady state of water in the body http://purl.obolibrary.org/obo/MP_0011445 abnormal renal protein reabsorption http://purl.obolibrary.org/obo/MP_0010107 abnormal renal reabsorbtion any anomaly in the process in which proteins are taken up from the collecting ducts and proximal and distal loops of the nephron http://purl.obolibrary.org/obo/MP_0011446 abnormal renal albumin reabsorption http://purl.obolibrary.org/obo/MP_0011445 abnormal renal protein reabsorption any anomaly in the process in which albumin is taken up from the collecting ducts and proximal and distal loops of the nephron http://purl.obolibrary.org/obo/MP_0011447 abnormal renal glucose reabsorption http://purl.obolibrary.org/obo/MP_0010107 abnormal renal reabsorbtion any anomaly in the process in which glucose is taken up from the collecting ducts and proximal and distal loops of the nephron http://purl.obolibrary.org/obo/MP_0011448 decreased dopaminergic neuron number http://purl.obolibrary.org/obo/MP_0008948 decreased neuron number fewer than normal numbers of the neurons that utilize dopamine as a neurotransmitter http://purl.obolibrary.org/obo/MP_0011449 increased dopaminergic neuron number http://purl.obolibrary.org/obo/MP_0008947 increased neuron number greater than normal numbers of the neurons that utilize dopamine as a neurotransmitter http://purl.obolibrary.org/obo/MP_0011450 ectopic dopaminergic neuron http://purl.obolibrary.org/obo/MP_0011723 ectopic neuron abnormal location of one or more of the neurons that utilize dopamine as a neurotransmitter http://purl.obolibrary.org/obo/MP_0011451 increased susceptibility to dopaminergic neuron neurotoxicity http://purl.obolibrary.org/obo/MP_0008235 increased susceptibility to neuronal excitotoxicity greater than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism http://purl.obolibrary.org/obo/MP_0011452 decreased susceptibility to dopaminergic neuron neurotoxicity http://purl.obolibrary.org/obo/MP_0008236 decreased susceptibility to neuronal excitotoxicity less than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism http://purl.obolibrary.org/obo/MP_0011453 abnormal glomerular capillary endothelium morphology http://purl.obolibrary.org/obo/MP_0011320 abnormal glomerular capillary morphology any structural anomaly of the thin, extremely flattened layer of cells that line the interior surface of glomerular capillaries and is densely perforated by large transcellular pores (aka fenestrae or fenestrations) that, unlike those of other fenestrated capillaries, are generally thought to lack diaphragms http://purl.obolibrary.org/obo/MP_0011454 abnormal glomerular endothelium fenestra morphology http://purl.obolibrary.org/obo/MP_0011453 abnormal glomerular capillary endothelium morphology any structural anomaly of the large plasma membrane-lined circular pores that perforate the flattened glomerular endothelium and, unlike those of other fenestrated capillaries, are not spanned by diaphragms; the density and size of glomerular fenestrae account, at least in part, for the high permeability of the glomerular capillary wall to water and small solutes http://purl.obolibrary.org/obo/MP_0011455 absent glomerular endothelium fenestra http://purl.obolibrary.org/obo/MP_0011454 abnormal glomerular endothelium fenestra morphology absence of the large plasma membrane-lined circular pores that normally perforate the flattened glomerular endothelium; loss of fenestrae may lead to a reduction in the glomerular filtration rate or proteinuria http://purl.obolibrary.org/obo/MP_0011456 abnormal ureter ureteric bud development http://purl.obolibrary.org/obo/MP_0006032 abnormal ureteric bud morphology any anomaly in the development of the elongated stalk of the ureteric bud that contributes to the morphogenesis of the ureter; the ureter ureteric bud is the initial structure that forms the ureter http://purl.obolibrary.org/obo/MP_0011457 abnormal metanephric ureteric bud development http://purl.obolibrary.org/obo/MP_0006032 abnormal ureteric bud morphology any anomaly in the development of the portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros http://purl.obolibrary.org/obo/MP_0011458 abnormal urine chloride ion level http://purl.obolibrary.org/obo/MP_0012007 abnormal chloride level any change in the amount of chloride ion in the urine http://purl.obolibrary.org/obo/MP_0011497 abnormal glomerular capsule visceral layer morphology http://purl.obolibrary.org/obo/MP_0002828 abnormal renal glomerular capsule morphology any structural anomaly of the inner layer of the glomerular capsule surrounding the capillary endothelial cells and composed of highly specialized epithelial cells (podocytes) that are separated by filtration slits; the visceral layer is separated from the outer parietal layer by the urinary space (also known as the Bowman's or capsular space) http://purl.obolibrary.org/obo/MP_0011514 skin hemorrhage http://purl.obolibrary.org/obo/MP_0002060 abnormal skin morphology bleeding into the skin http://purl.obolibrary.org/obo/MP_0011518 abnormal cell chemotaxis http://purl.obolibrary.org/obo/MP_0003091 abnormal cell migration any anomaly in the directed movement of a motile cell guided by a specific chemical concentration gradient; movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis) http://purl.obolibrary.org/obo/MP_0011566 abnormal complement protein level http://purl.obolibrary.org/obo/MP_0008469 abnormal protein level deviation from the normal levels, or accumulation of the proteins that act sequentially to allow for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes http://purl.obolibrary.org/obo/MP_0011572 abnormal aorta bulb morphology http://purl.obolibrary.org/obo/MP_0009867 abnormal ascending aorta morphology any structural anomaly of the portion of the left ventricular outflow tract delineated by the sinotubular ridge superiorly and the bases of the valve leaflets inferiorly; it comprises the aortic sinuses, the aortic valve leaflets, the commissures, and the interleaflet triangles http://purl.obolibrary.org/obo/MP_0011648 thick heart valve cusps http://purl.obolibrary.org/obo/MP_0000285 abnormal heart valve morphology an increase in the heart cusp wall thickness http://purl.obolibrary.org/obo/MP_0011804 increased cell migration http://purl.obolibrary.org/obo/MP_0003091 abnormal cell migration increased or faster movement of cells from one site to another, often occurring during developmental or chemotactic processes http://purl.obolibrary.org/obo/MP_0011805 decreased cell migration http://purl.obolibrary.org/obo/MP_0003091 abnormal cell migration reduced or slower movement of cells from one site to another, often occurring during developmental or chemotactic processes http://purl.obolibrary.org/obo/MP_0011832 abnormal visual acuity http://purl.obolibrary.org/obo/MP_0002090 abnormal vision any abnormality in the spatial resolution or resolving power of the visual processing system http://purl.obolibrary.org/obo/MP_0011888 abnormal circulating total protein level http://purl.obolibrary.org/obo/MP_0005416 abnormal circulating protein level total serum protein concentration is outside the normal range http://purl.obolibrary.org/obo/MP_0011932 abnormal endocrine pancreas development http://purl.obolibrary.org/obo/MP_0003934 abnormal pancreas development anomaly in the formation of the smaller portion of the pancreas that secretes a number of hormones into the blood stream that are produced by the cells in the islets of Langerhans http://purl.obolibrary.org/obo/MP_0011961 abnormal cornea thickness http://purl.obolibrary.org/obo/MP_0001312 abnormal cornea morphology increased or decreased width of the cornea in the center plane http://purl.obolibrary.org/obo/MP_0011996 abnormal retinal inner nuclear layer thickness http://purl.obolibrary.org/obo/MP_0003733 abnormal retinal inner nuclear layer morphology anomaly in the thickness of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells http://purl.obolibrary.org/obo/MP_0011997 abnormal retinal outer nuclear layer thickness http://purl.obolibrary.org/obo/MP_0003731 abnormal retinal outer nuclear layer morphology anomaly in the thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones http://purl.obolibrary.org/obo/MP_0012028 abnormal visceral endoderm physiology http://purl.obolibrary.org/obo/MP_0001672 abnormal embryogenesis/ development any functional anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut http://purl.obolibrary.org/obo/MP_0012056 abnormal polar trophectoderm morphology http://purl.obolibrary.org/obo/MP_0005028 abnormal trophectoderm morphology any structural anomaly of the trophectoderm portion that surrounds the inner cell mass (ICM); unlike mural trophectoderm cells which stop proliferating and become large polyploid cells (the primary trophoblastic giant cells) by endoreduplication, polar trophectoderm cells remain diploid, continue to proliferate and give rise to both the ectoplacental cone and the extraembryonic ectoderm http://purl.obolibrary.org/obo/MP_0012057 abnormal mural trophectoderm morphology http://purl.obolibrary.org/obo/MP_0005028 abnormal trophectoderm morphology any structural anomaly of the trophectoderm portion distal to the ICM that overlays the blastocyst cavity and gives rise to polyploid trophoblast giant cells http://purl.obolibrary.org/obo/MP_0012079 abnormal spinal reflex http://purl.obolibrary.org/obo/MP_0001961 abnormal reflex any anomaly in the reflexive action mediated by cells of the spinal cord, or the involuntary movement reaction caused by the application of a stimulus to an organism; these include signals originating from heat from burning, sharp sensations, and other painful feelings http://purl.obolibrary.org/obo/MP_0012176 abnormal head development http://purl.obolibrary.org/obo/MP_0000432 abnormal head morphology anomaly in the process in which the anatomical structures of the head are generated and organized http://purl.obolibrary.org/obo/MP_0012227 decreased brain sterol level http://purl.obolibrary.org/obo/MP_0012225 decreased sterol level reduced level in the brain of any of a group of predominantly unsaturated solid alcohols of the steroid group, usually with a hydroxyl group (OH) attached to the third carbon atom, and are present in the fatty tissues of plants and animals; sterols may be found either as free sterols, acylated, alkylated, sulfated, or linked to a glycoside moiety which can be itself acylated http://purl.obolibrary.org/obo/MP_0012228 increased brain sterol level http://purl.obolibrary.org/obo/MP_0012226 increased sterol level greater level in the brain of any of a group of predominantly unsaturated solid alcohols of the steroid group, usually with a hydroxyl group (OH) attached to the third carbon atom, and are present in the fatty tissues of plants and animals; sterols may be found either as free sterols, acylated, alkylated, sulfated, or linked to a glycoside moiety which can be itself acylated http://purl.obolibrary.org/obo/MP_0012253 abnormal intersomitic vessel morphology http://purl.obolibrary.org/obo/MP_0001614 abnormal blood vessel morphology any structural anomaly of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites http://purl.obolibrary.org/obo/MP_0012316 enhanced conditioning behavior http://purl.obolibrary.org/obo/MP_0002063 abnormal learning/memory/conditioning enhanced ability to change behavior in response to a reward or punishment each time an action is performed http://purl.obolibrary.org/obo/MP_0012317 impaired conditioning behavior http://purl.obolibrary.org/obo/MP_0002063 abnormal learning/memory/conditioning impaired ability to change behavior in response to a reward or punishment each time an action is performed http://purl.obolibrary.org/obo/MP_0012397 abnormal nucleated erythrocyte cell number http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology abnormal numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells http://purl.obolibrary.org/obo/MP_0012416 decreased gland tumor incidence http://purl.obolibrary.org/obo/MP_0010282 decreased organ/body region tumor incidence less than the expected number of tumors originating in a gland in a given population in a given time period http://purl.obolibrary.org/obo/MP_0012421 decreased hepatobiliary system tumor incidence http://purl.obolibrary.org/obo/MP_0010282 decreased organ/body region tumor incidence less than the expected number of tumors originating in the hepatobiliary system in a given population in a given time period http://purl.obolibrary.org/obo/MP_0012422 decreased integument system tumor incidence http://purl.obolibrary.org/obo/MP_0010282 decreased organ/body region tumor incidence less than the expected number of tumors originating in the integument system in a given population in a given time period http://purl.obolibrary.org/obo/MP_0012424 decreased alimentary system tumor incidence http://purl.obolibrary.org/obo/MP_0010282 decreased organ/body region tumor incidence less than the expected number of tumors originating in the alimentary system in a given population in a given time period http://purl.obolibrary.org/obo/MP_0012533 uveal coloboma http://purl.obolibrary.org/obo/MP_0005262 coloboma congenital defect of the uvea in which some part of the structure is absent http://purl.obolibrary.org/obo/MP_0012547 spina bifida cystica http://purl.obolibrary.org/obo/MP_0003054 spina bifida spinal bifida in which a hernial cyst containing meninges (meningocele), spinal cord (myelocele), or both (myelomeningocele) protrudes through a congenital cleft in the vertebral column; the protruding sac is encased in a layer of skin or a fine membrane that readily ruptures, causing leakage of cerebrospinal fluid and an increased risk of meningeal infection http://purl.obolibrary.org/obo/MP_0012555 decreased cell death http://purl.obolibrary.org/obo/MP_0000313 abnormal cell death decreased occurrence of the cessation of function at the cellular level http://purl.obolibrary.org/obo/MP_0012556 increased cell death http://purl.obolibrary.org/obo/MP_0000313 abnormal cell death increased occurrence of the cessation of function at the cellular level http://purl.obolibrary.org/obo/MP_0012574 decreased noradrenaline level http://purl.obolibrary.org/obo/MP_0003964 abnormal noradrenaline level reduced amount of the hormone secreted by the adrenal medulla and acts as a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS; noradrenaline is the demethylated biosynthetic precursor of epinephrine http://purl.obolibrary.org/obo/MP_0012575 increased noradrenaline level http://purl.obolibrary.org/obo/MP_0003964 abnormal noradrenaline level greater than normal amount of the hormone secreted by the adrenal medulla and acts as a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS; noradrenaline is the demethylated biosynthetic precursor of epinephrine http://purl.obolibrary.org/obo/MP_0012763 abnormal alpha-beta T cell number http://purl.obolibrary.org/obo/MP_0012762 abnormal alpha-beta T cell morphology aberrant number of T cells that expresses an alpha-beta T cell receptor complex http://purl.obolibrary.org/obo/MP_0012764 increased alpha-beta T cell number http://purl.obolibrary.org/obo/MP_0012763 abnormal alpha-beta T cell number greater number of T cells that expresses an alpha-beta T cell receptor complex http://purl.obolibrary.org/obo/MP_0012765 decreased alpha-beta T cell number http://purl.obolibrary.org/obo/MP_0012763 abnormal alpha-beta T cell number reduced number of T cells that expresses an alpha-beta T cell receptor complex http://purl.obolibrary.org/obo/MP_0012769 abnormal CD4-positive, alpha-beta memory T cell number http://purl.obolibrary.org/obo/MP_0008073 abnormal CD4-positive, alpha beta T cell number anomaly in the number of CD4-positive, alpha-beta long-lived T cells with the phenotype CD45RO-positive and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high http://purl.obolibrary.org/obo/MP_0012770 abnormal effector memory CD4-positive, alpha-beta T cell number http://purl.obolibrary.org/obo/MP_0012769 abnormal CD4-positive, alpha-beta memory T cell number anomaly in the number of a CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative http://purl.obolibrary.org/obo/MP_0012771 abnormal central memory CD4-positive, alpha-beta T cell number http://purl.obolibrary.org/obo/MP_0012769 abnormal CD4-positive, alpha-beta memory T cell number anomaly in the number of a CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative http://purl.obolibrary.org/obo/MP_0012772 abnormal central memory CD8-positive, alpha-beta T cell number http://purl.obolibrary.org/obo/MP_0012774 abnormal CD8-positive, alpha-beta memory T cell number an anomaly in the number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-positive, CD127-positive, CD45RO-positive, and CD25-negative http://purl.obolibrary.org/obo/MP_0012773 abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number http://purl.obolibrary.org/obo/MP_0008397 abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology any anomaly in the number of the CD4-positive, CD25-positive T cell subset which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release http://purl.obolibrary.org/obo/MP_0012774 abnormal CD8-positive, alpha-beta memory T cell number http://purl.obolibrary.org/obo/MP_0010837 abnormal CD8-positive, alpha-beta memory T cell morphology an anomaly in the number of CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive; this cell type is also described as being CD25-negative, CD44-high, and CD122-high http://purl.obolibrary.org/obo/MP_0012776 abnormal liver cholesterol level http://purl.obolibrary.org/obo/MP_0003947 abnormal cholesterol level aberrant amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues http://purl.obolibrary.org/obo/MP_0012777 abnormal liver glycogen level http://purl.obolibrary.org/obo/MP_0005437 abnormal glycogen level abnormal concentration of a readily converted carbohydrate reserve in liver http://purl.obolibrary.org/obo/MP_0012778 abnormal liver triglyceride level http://purl.obolibrary.org/obo/MP_0000598 abnormal liver morphology aberrant concentration of naturally occurring esters of three fatty acids and glycerol in the liver; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liverower than normal concentration of triacylglycerols in the liver http://purl.obolibrary.org/obo/MP_0012779 abnormal brain cholesterol level http://purl.obolibrary.org/obo/MP_0003947 abnormal cholesterol level aberrant amount in the brain of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues http://purl.obolibrary.org/obo/MP_0012783 abnormal extensor digitorum longus weight http://purl.obolibrary.org/obo/MP_0004246 abnormal extensor digitorum longus morphology anomaly in the weight of the penniform muscle of the lateral front part of the leg responsible for extension of the toes and dorsiflexion of the ankle http://purl.obolibrary.org/obo/MP_0013129 abnormal tooth color http://purl.obolibrary.org/obo/MP_0002100 abnormal tooth morphology anomaly in the color and shading of the teeth, which normally present in shades of white http://purl.obolibrary.org/obo/MP_0013152 abnormal organ/body region tumor incidence http://purl.obolibrary.org/obo/MP_0002019 abnormal tumor incidence anomaly in the expected number of tumors originating in a specific body region or organ in a given population in a given time period http://purl.obolibrary.org/obo/MP_0013177 abnormal tail tip morphology http://purl.obolibrary.org/obo/MP_0002111 abnormal tail morphology any structural anomaly of the distal end of the tail http://purl.obolibrary.org/obo/MP_0013188 abnormal gastrocnemius weight http://purl.obolibrary.org/obo/MP_0003082 abnormal gastrocnemius morphology any anomaly of the weight of the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles http://purl.obolibrary.org/obo/MP_0013205 abnormal nonmotile primary cilium morphology http://purl.obolibrary.org/obo/MP_0013203 abnormal primary cilium morphology any structural anomaly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors; nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules http://purl.obolibrary.org/obo/MP_0013206 abnormal motile cilium morphology http://purl.obolibrary.org/obo/MP_0013202 abnormal cilium morphology any structural anomaly of a cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface; motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues and may also function as sensory organelles http://purl.obolibrary.org/obo/MP_0013209 abnormal motile cilium physiology http://purl.obolibrary.org/obo/MP_0013208 abnormal cilium physiology any structural anomaly of a cilium which has a variable arrangement of axonemal microtubules, contains molecular motors, and beats with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface; motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues and may also function as sensory organelles http://purl.obolibrary.org/obo/MP_0013210 abnormal primary cilium physiology http://purl.obolibrary.org/obo/MP_0013208 abnormal cilium physiology any functional anomaly of a cilium found on many different cell types that is typically present in a single copy per cell; a primary cilium may have a variable array of axonemal microtubules and may or may not contain molecular motors http://purl.obolibrary.org/obo/MP_0013244 abnormal vitamin metabolism http://purl.obolibrary.org/obo/MP_0013274 abnormal vitamin or vitamin cofactor metabolism any anomaly in the chemical reactions and pathways involving a vitamin, including metabolic, catabolic and biosynthetic processes http://purl.obolibrary.org/obo/MP_0013280 abnormal cytotoxic T cell cytolysis http://purl.obolibrary.org/obo/MP_0005078 abnormal cytotoxic T cell physiology altered ability of cytotoxic T cells to induce pathological breakdown of target cells by the destruction of their outer membrane http://purl.obolibrary.org/obo/MP_0013285 abnormal renal filtration http://purl.obolibrary.org/obo/MP_0002136 abnormal kidney physiology any anomaly in the renal system process in which fluid circulating through the body is filtered through a barrier system http://purl.obolibrary.org/obo/MP_0013287 abnormal acrosome reaction http://purl.obolibrary.org/obo/MP_0008546 abnormal vesicle-mediated transport abnormality in the cellular exocytosis of a single, anterior secretory granule following a sperm's attachment to the zona pellucida surrounding an oocyte http://purl.obolibrary.org/obo/MP_0013292 embryonic lethality prior to organogenesis http://purl.obolibrary.org/obo/MP_0013293 embryonic lethality prior to tooth bud stage death prior to the completion of embryo turning (Mus: E9-9.5) http://purl.obolibrary.org/obo/MP_0013295 pancreas atrophy http://purl.obolibrary.org/obo/MP_0001944 abnormal pancreas morphology acquired size diminution of any portion of the pancreas, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0013296 abnormal susceptibility to induced colitis http://purl.obolibrary.org/obo/MP_0002816 colitis difference in the severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS) http://purl.obolibrary.org/obo/MP_0013300 abnormal submandibular gland physiology http://purl.obolibrary.org/obo/MP_0005310 abnormal salivary gland physiology any functional anomaly of either of the large major salivary glands situated beneath the mandible http://purl.obolibrary.org/obo/MP_0013316 abnormal pheomelanosome pheomelanin content http://purl.obolibrary.org/obo/MP_0013315 abnormal pheomelanosome morphology anomaly in the amount or distribution of yellow pigment in the pheomelanosomes of melanocytes http://purl.obolibrary.org/obo/MP_0013411 abnormal Langerhans cell number http://purl.obolibrary.org/obo/MP_0008117 abnormal Langerhans cell morphology anomaly in the number of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus http://purl.obolibrary.org/obo/MP_0020130 abnormal total fat pad weight http://purl.obolibrary.org/obo/MP_0005334 abnormal fat pad morphology anomaly in average total weight of the fat pad compared to controls http://purl.obolibrary.org/obo/MP_0020134 abnormal gallbladder size http://purl.obolibrary.org/obo/MP_0005084 abnormal gallbladder morphology an anomaly in the size of the gall bladder compared to average, the organ that serves as a storage reservoir for bile http://purl.obolibrary.org/obo/MP_0020136 abnormal interventricular septum thickness http://purl.obolibrary.org/obo/MP_0000281 abnormal interventricular septum morphology an anomaly in the thickness of the wall between the two lower chambers of the heart compared to the control http://purl.obolibrary.org/obo/MP_0020148 abnormal sensitivity to induced morbidity/mortality http://purl.obolibrary.org/obo/MP_0001657 abnormal induced morbidity/mortality anomaly in the amount of an external agent required to cause death or diseased state http://purl.obolibrary.org/obo/MP_0020152 abnormal oocyte number http://purl.obolibrary.org/obo/MP_0001125 abnormal oocyte morphology anomaly in the number of germ cells in the female compared to the control http://purl.obolibrary.org/obo/MP_0020157 abnormal behavioral response to alcohol http://purl.obolibrary.org/obo/MP_0009748 abnormal behavioral response to addictive substance any anomaly in the behavioral response induced by alcohol, such as induced hyperactivity or stereotypic behavior http://purl.obolibrary.org/obo/MP_0020158 abnormal behavioral response to cocaine http://purl.obolibrary.org/obo/MP_0009748 abnormal behavioral response to addictive substance any anomaly in the behavioral response induced by cocaine, such as induced hyperactivity or stereotypic behavior http://purl.obolibrary.org/obo/MP_0020159 abnormal behavioral response to morphine http://purl.obolibrary.org/obo/MP_0009748 abnormal behavioral response to addictive substance any anomaly in the behavioral response induced by morphine, such as induced hyperactivity or stereotypic behavior http://purl.obolibrary.org/obo/MP_0020160 abnormal behavioral response to nicotine http://purl.obolibrary.org/obo/MP_0009748 abnormal behavioral response to addictive substance any anomaly in the behavioral response induced by nicotine, such as induced hyperactivity or stereotypic behavior http://purl.obolibrary.org/obo/MP_0020164 abnormal quadriceps weight http://purl.obolibrary.org/obo/MP_0010225 abnormal quadriceps morphology anomaly in the weight of the group of four muscles (rectus femoris, vastus intermedius, vastus lateralis, and vastus medialis) which extend down the front of the thigh and are the major extensors of the knee joint http://purl.obolibrary.org/obo/MP_0020165 abnormal soleus weight http://purl.obolibrary.org/obo/MP_0003081 abnormal soleus morphology anomaly in the weight of the superficial flat broad muscle of the calf that is responsible for plantar flexion of the foot http://purl.obolibrary.org/obo/MP_0020166 abnormal tibialis anterior weight http://purl.obolibrary.org/obo/MP_0003083 abnormal tibialis anterior morphology anomaly in the weight of the muscle of the shin that is responsible for dorsiflexion and inversion of the foot http://purl.obolibrary.org/obo/MP_0020175 abnormal IgG1 level http://purl.obolibrary.org/obo/MP_0020174 abnormal IgG level deviation from the normal levels of immunoglobulin class G1 level http://purl.obolibrary.org/obo/MP_0020176 abnormal IgG2a level http://purl.obolibrary.org/obo/MP_0020174 abnormal IgG level deviation from the normal levels of immunoglobulin class G2a level http://purl.obolibrary.org/obo/MP_0020177 abnormal IgG2b level http://purl.obolibrary.org/obo/MP_0020174 abnormal IgG level deviation from the normal levels of immunoglobulin class G2b level http://purl.obolibrary.org/obo/MP_0020178 abnormal IgG2c level http://purl.obolibrary.org/obo/MP_0020174 abnormal IgG level deviation from the normal levels of immunoglobulin class G2c level http://purl.obolibrary.org/obo/MP_0020179 abnormal IgG3 level http://purl.obolibrary.org/obo/MP_0020174 abnormal IgG level deviation from the normal levels of immunoglobulin class G3 level http://purl.obolibrary.org/obo/MP_0020182 abnormal body mass index http://purl.obolibrary.org/obo/MP_0005451 abnormal body composition anomaloy in the average of a measure of weight for height compared to the control http://purl.obolibrary.org/obo/MP_0020183 altered susceptibility to fungal infection http://purl.obolibrary.org/obo/MP_0001793 altered susceptibility to infection a change in the likelihood that an organism will develop ill effects from a fungal infection or from components of or toxins produced by a fungi http://purl.obolibrary.org/obo/MP_0020184 altered susceptibility to parasitic infection http://purl.obolibrary.org/obo/MP_0001793 altered susceptibility to infection a change in the likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by a parasite http://purl.obolibrary.org/obo/MP_0020187 altered susceptibility to prion infection http://purl.obolibrary.org/obo/MP_0001793 altered susceptibility to infection altered likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is a major and necessary component http://purl.obolibrary.org/obo/MP_0020188 abnormal classified tumor incidence http://purl.obolibrary.org/obo/MP_0002019 abnormal tumor incidence an anomaly in the expected number of tumors with a specific classification type in a given population in a given time period http://purl.obolibrary.org/obo/MP_0020189 abnormal adenoma incidence http://purl.obolibrary.org/obo/MP_0020188 abnormal classified tumor incidence an anomaly in the expected number of a benign epithelial neoplasm with a glandular organization, occurring in a specific population in a given time period; this tumor type usually does not invade or infiltrate surrounding tissue but may remain a benign tumor or progress to malignancy http://purl.obolibrary.org/obo/MP_0020279 abnormal creatine kinase level http://purl.obolibrary.org/obo/MP_0005319 abnormal enzyme/ coenzyme level abnormal level of the enzyme that catalyzes the reversible transfer of creatine to phosphocreatine http://purl.obolibrary.org/obo/MP_0020280 increased creatine kinase level http://purl.obolibrary.org/obo/MP_0020279 abnormal creatine kinase level increased level of the enzyme that catalyzes the reversible transfer of creatine to phosphocreatine http://purl.obolibrary.org/obo/MP_0020281 decreased creatine kinase level http://purl.obolibrary.org/obo/MP_0020279 abnormal creatine kinase level decreased level of the enzyme that catalyzes the reversible transfer of creatine to phosphocreatine http://purl.obolibrary.org/obo/MP_0001726 abnormal allantois morphology http://purl.obolibrary.org/obo/MP_0002086 abnormal extraembryonic tissue morphology any structural anomaly fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels http://purl.obolibrary.org/obo/BFO_0000004 independent continuant http://purl.obolibrary.org/obo/BFO_0000002 continuant A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything. http://purl.obolibrary.org/obo/BFO_0000040 material entity http://purl.obolibrary.org/obo/BFO_0000004 independent continuant An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time. http://purl.obolibrary.org/obo/CHEBI_75761 Escherichia coli metabolite http://purl.obolibrary.org/obo/CHEBI_75760 bacterial metabolite Any bacterial metabolite produced during a metabolic reaction in Escherichia coli. http://purl.obolibrary.org/obo/CHEBI_50646 bone density conservation agent http://purl.obolibrary.org/obo/CHEBI_23888 drug An agent that inhibits bone resorption and/or favor bone mineralization and bone regeneration. Used to heal bone fractures and to treat bone diseases such as osteopenia and osteoporosis. http://purl.obolibrary.org/obo/CHEBI_75772 yeast metabolite http://purl.obolibrary.org/obo/CHEBI_75765 fungal metabolite Any fungal metabolite produced during a metabolic reaction in yeast (Saccharomyces cerevisiae). http://purl.obolibrary.org/obo/CHEBI_35482 opioid analgesic http://purl.obolibrary.org/obo/CHEBI_35480 analgesic A narcotic or opioid substance, synthetic or semisynthetic agent producing profound analgesia, drowsiness, and changes in mood. http://purl.obolibrary.org/obo/CHEBI_38317 HPPD inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Inhibitor of 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27). http://purl.obolibrary.org/obo/CHEBI_38867 anaesthetic http://purl.obolibrary.org/obo/CHEBI_23888 drug Substance which produces loss of feeling or sensation. http://purl.obolibrary.org/obo/CHEBI_55322 mu-opioid receptor agonist http://purl.obolibrary.org/obo/CHEBI_60606 opioid receptor agonist A compound that exhibits agonist activity at the mu-opioid receptor. http://purl.obolibrary.org/obo/CHEBI_60807 anaesthesia adjuvant http://purl.obolibrary.org/obo/CHEBI_60809 adjuvant Any substance that possesses little anaesthetic effect by itself, but which enhances or potentiates the anaesthetic action of other drugs when given at the same time. http://purl.obolibrary.org/obo/CHEBI_60809 adjuvant http://purl.obolibrary.org/obo/CHEBI_52217 pharmaceutical Any pharmacological or immunological agent that modifies the effect of other agents such as drugs or vaccines while having few if any direct effects when given by itself. http://purl.obolibrary.org/obo/CHEBI_72768 aryl hydrocarbon receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist An agonist that binds to and activates aryl hydrocarbon receptors (AhRs). http://purl.obolibrary.org/obo/CHEBI_15022 electron donor http://purl.obolibrary.org/obo/CHEBI_17891 donor A molecular entity that can transfer an electron to another molecular entity. http://purl.obolibrary.org/obo/CHEBI_15339 acceptor http://purl.obolibrary.org/obo/CHEBI_51086 chemical role A molecular entity that can accept an electron, a pair of electrons, an atom or a group from another molecular entity. http://purl.obolibrary.org/obo/CHEBI_17891 donor http://purl.obolibrary.org/obo/CHEBI_51086 chemical role A molecular entity that can transfer ("donate") an electron, a pair of electrons, an atom or a group to another molecular entity. http://purl.obolibrary.org/obo/CHEBI_22153 acaricide http://purl.obolibrary.org/obo/CHEBI_25944 pesticide A substance used to destroy pests of the subclass Acari (mites and ticks). http://purl.obolibrary.org/obo/CHEBI_23530 cytokinin http://purl.obolibrary.org/obo/CHEBI_37848 plant hormone A phytohormone that promote cell division, or cytokinesis, in plant roots and shoots. http://purl.obolibrary.org/obo/CHEBI_23888 drug http://purl.obolibrary.org/obo/CHEBI_52217 pharmaceutical Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances. http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role A compound or agent that combines with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. http://purl.obolibrary.org/obo/CHEBI_24621 hormone http://purl.obolibrary.org/obo/CHEBI_33280 molecular messenger Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds. http://purl.obolibrary.org/obo/CHEBI_25442 mycotoxin http://purl.obolibrary.org/obo/CHEBI_27026 toxin Poisonous substance produced by fungi. http://purl.obolibrary.org/obo/CHEBI_25728 osmolyte http://purl.obolibrary.org/obo/CHEBI_24432 biological role A solute used by a cell under water stress to maintain cell volume. http://purl.obolibrary.org/obo/CHEBI_26348 prosthetic group http://purl.obolibrary.org/obo/CHEBI_23357 cofactor A tightly bound, specific nonpolypeptide unit in a protein determining and involved in its biological activity. http://purl.obolibrary.org/obo/CHEBI_26672 siderophore http://purl.obolibrary.org/obo/CHEBI_24874 iron ionophore Any of low-molecular-mass iron(III)-chelating compounds produced by microorganisms for the purpose of the transport and sequestration of iron. http://purl.obolibrary.org/obo/CHEBI_33284 nutrient http://purl.obolibrary.org/obo/CHEBI_52211 physiological role A nutrient is a chemical element needed by all life forms. http://purl.obolibrary.org/obo/CHEBI_35443 anthelminthic drug http://purl.obolibrary.org/obo/CHEBI_35442 antiparasitic agent Substance intended to kill parasitic worms (helminths). http://purl.obolibrary.org/obo/CHEBI_35481 non-narcotic analgesic http://purl.obolibrary.org/obo/CHEBI_35480 analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. http://purl.obolibrary.org/obo/CHEBI_35522 beta-adrenergic agonist http://purl.obolibrary.org/obo/CHEBI_48540 beta-adrenergic drug An agent that selectively binds to and activates beta-adrenergic receptors. http://purl.obolibrary.org/obo/CHEBI_35524 sympathomimetic agent http://purl.obolibrary.org/obo/CHEBI_37962 adrenergic agent A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters. http://purl.obolibrary.org/obo/CHEBI_35554 cardiovascular drug http://purl.obolibrary.org/obo/CHEBI_23888 drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. http://purl.obolibrary.org/obo/CHEBI_35820 antiprotozoal drug http://purl.obolibrary.org/obo/CHEBI_36043 antimicrobial drug Any antimicrobial drug which is used to treat or prevent protozoal infections. http://purl.obolibrary.org/obo/CHEBI_36063 oxytocic http://purl.obolibrary.org/obo/CHEBI_23888 drug A drug that stimulates contraction of the myometrium. Oxytocics are used to induce labour, obstetric at term, to prevent or control postpartum or postabortion haemorrhage, and to assess foetal status in high risk pregnancies. They may also be used alone or with other drugs to induce abortions (abortifacients). http://purl.obolibrary.org/obo/CHEBI_37338 radioopaque medium http://purl.obolibrary.org/obo/CHEBI_37334 diagnostic imaging agent A substance having the property of absorbing, and therefore being opaque to, electromagnetic radiation, particularly X-rays. http://purl.obolibrary.org/obo/CHEBI_37527 acid http://purl.obolibrary.org/obo/CHEBI_51086 chemical role An acid is a molecular entity capable of donating a hydron (Bronsted acid) or capable of forming a covalent bond with an electron pair (Lewis acid). http://purl.obolibrary.org/obo/CHEBI_38068 antimalarial http://purl.obolibrary.org/obo/CHEBI_64915 antiplasmodial drug A drug used in the treatment of malaria. Antimalarials are usually classified on the basis of their action against Plasmodia at different stages in their life cycle in the human. http://purl.obolibrary.org/obo/CHEBI_38324 cholinergic agonist http://purl.obolibrary.org/obo/CHEBI_38323 cholinergic drug Any drug that binds to and activates cholinergic receptors. http://purl.obolibrary.org/obo/CHEBI_47958 nicotinic agonist http://purl.obolibrary.org/obo/CHEBI_38324 cholinergic agonist Any drug that binds to and activates a nicotinic cholinergic receptor. http://purl.obolibrary.org/obo/CHEBI_48001 protein synthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor A compound, usually an anti-bacterial agent or a toxin, which inhibits the synthesis of a protein. http://purl.obolibrary.org/obo/CHEBI_48675 antifibrinolytic drug http://purl.obolibrary.org/obo/CHEBI_48676 fibrin modulating drug A drug that prevent fibrinolysis or lysis of a blood clot or thrombus. http://purl.obolibrary.org/obo/CHEBI_48887 bile acid metabolite http://purl.obolibrary.org/obo/CHEBI_26619 secondary metabolite Metabolites of bile acids, four-ringed steroid acids formed along the cholesterol degradation pathway. http://purl.obolibrary.org/obo/CHEBI_49023 prostaglandin antagonist http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist A compound that inhibits the action of prostaglandins. http://purl.obolibrary.org/obo/CHEBI_49110 peripheral nervous system drug http://purl.obolibrary.org/obo/CHEBI_23888 drug A drug that acts principally at one or more sites within the peripheral neuroeffector systems, the autonomic system, and motor nerve-skeletal system. http://purl.obolibrary.org/obo/CHEBI_50247 antidote http://purl.obolibrary.org/obo/CHEBI_50267 protective agent Any protective agent counteracting or neutralizing the action of poisons. http://purl.obolibrary.org/obo/CHEBI_50406 probe http://purl.obolibrary.org/obo/CHEBI_33232 application A role played by a molecular entity used to study the microscopic environment. http://purl.obolibrary.org/obo/CHEBI_50566 nitric oxide donor http://purl.obolibrary.org/obo/CHEBI_17891 donor An agent, with unique chemical structure and biochemical requirements, which generates nitric oxide. http://purl.obolibrary.org/obo/CHEBI_50630 cyclooxygenase 1 inhibitor http://purl.obolibrary.org/obo/CHEBI_35544 cyclooxygenase inhibitor A cyclooxygenase inhibitor with specificity for cyclooxygenase 1. http://purl.obolibrary.org/obo/CHEBI_50905 teratogenic agent http://purl.obolibrary.org/obo/CHEBI_52209 aetiopathogenetic role A role played by a chemical compound in biological systems with adverse consequences in embryo developments, leading to birth defects, embryo death or altered development, growth retardation and functional defect. http://purl.obolibrary.org/obo/CHEBI_50910 neurotoxin http://purl.obolibrary.org/obo/CHEBI_52209 aetiopathogenetic role A poison that interferes with the functions of the nervous system. http://purl.obolibrary.org/obo/CHEBI_50912 cardiotoxic agent http://purl.obolibrary.org/obo/CHEBI_52209 aetiopathogenetic role A role played by a chemical compound exihibiting itself through the ability to induce damage to the heart and cardiomyocytes. http://purl.obolibrary.org/obo/CHEBI_50926 angiogenesis modulating agent http://purl.obolibrary.org/obo/CHEBI_23888 drug An agent that modulates the physiologic angiogenesis process. This is accomplished by endogenous angiogenic proteins and a variety of other chemicals and pharmaceutical agents. http://purl.obolibrary.org/obo/CHEBI_51086 chemical role http://purl.obolibrary.org/obo/CHEBI_50906 role A role played by the molecular entity or part thereof within a chemical context. http://purl.obolibrary.org/obo/CHEBI_51177 antitussive http://purl.obolibrary.org/obo/CHEBI_23888 drug An agents that suppresses cough. http://purl.obolibrary.org/obo/CHEBI_51371 muscle relaxant http://purl.obolibrary.org/obo/CHEBI_51372 neuromuscular agent A drug used to produce muscle relaxation (excepting neuromuscular blocking agents). Its primary clinical and therapeutic use is the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. Also used for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in multiple sclerosis. http://purl.obolibrary.org/obo/CHEBI_52726 proteasome inhibitor http://purl.obolibrary.org/obo/CHEBI_23888 drug A drug that blocks the action of proteasomes, cellular complexes that break down proteins. http://purl.obolibrary.org/obo/CHEBI_53431 chain carrier http://purl.obolibrary.org/obo/CHEBI_51086 chemical role The role played by a molecular entity, such as an atom or free radical, which is involved in chain-propagating reactions. http://purl.obolibrary.org/obo/CHEBI_53784 antispasmodic drug http://purl.obolibrary.org/obo/CHEBI_51371 muscle relaxant A drug that suppresses spasms. These are usually caused by smooth muscle contraction, especially in tubular organs. The effect is to prevent spasms of the stomach, intestine or urinary bladder. http://purl.obolibrary.org/obo/CHEBI_55350 neurokinin-1 receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist An antagonist at the neurokinin-1 receptor. http://purl.obolibrary.org/obo/CHEBI_59174 hapten http://purl.obolibrary.org/obo/CHEBI_24432 biological role Any substance capable of eliciting an immune response only when attached to a large carrier such as a protein. Examples include dinitrophenols; oligosaccharides; peptides; and heavy metals. http://purl.obolibrary.org/obo/CHEBI_59740 nucleophilic reagent http://purl.obolibrary.org/obo/CHEBI_39144 Lewis base A reagent that forms a bond to its reaction partner (the electrophile) by donating both bonding electrons. http://purl.obolibrary.org/obo/CHEBI_60643 N-methyl-D-aspartate receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist Any chemical substance that acts as an antagonist at the N-methyl-D-aspartate receptor. http://purl.obolibrary.org/obo/CHEBI_62049 acyl donor http://purl.obolibrary.org/obo/CHEBI_17891 donor Any donor that can transfer acyl groups between molecular entities. http://purl.obolibrary.org/obo/CHEBI_63156 alcohol oxidase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of alcohol oxidase. http://purl.obolibrary.org/obo/CHEBI_63157 cystathionine-beta-synthase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of cystathionine-beta-synthase. http://purl.obolibrary.org/obo/CHEBI_63158 carnitine palmitoyltransferase-1 inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of mitochondrial carnitine palmitoyltransferase-1. http://purl.obolibrary.org/obo/CHEBI_63248 oxidising agent http://purl.obolibrary.org/obo/CHEBI_51086 chemical role A substance that removes electrons from another reactant in a redox reaction. http://purl.obolibrary.org/obo/CHEBI_63794 retinoid X receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist An agonist that selectively binds to and activates a retinoid X receptor. http://purl.obolibrary.org/obo/CHEBI_63958 cellulose synthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits the synthesis of cellulose. http://purl.obolibrary.org/obo/CHEBI_64570 serine hydroxymethyltransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of serine hydroxymethyltransferase. http://purl.obolibrary.org/obo/CHEBI_64584 uremic toxin http://purl.obolibrary.org/obo/CHEBI_27026 toxin A toxin that accumulates in patients with chronic kidney disease. http://purl.obolibrary.org/obo/CHEBI_64588 glycine transporter 1 inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor Any substance that inhibits the action of glycine 1 transporters. http://purl.obolibrary.org/obo/CHEBI_64589 glycine receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist An agonist that binds to and activates glycine receptors http://purl.obolibrary.org/obo/CHEBI_64697 acyl-CoA:cholesterol acyltransferase 2 inhibitor http://purl.obolibrary.org/obo/CHEBI_64696 acyl-CoA:cholesterol acyltransferase inhibitor An acyl-CoA:cholesterol acyltransferase inhibitor that specifically inhibits acyl-CoA:cholesterol acyltransferase 2. http://purl.obolibrary.org/obo/CHEBI_64911 antimitotic http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role Any compound that inhibits cell division (mitosis). http://purl.obolibrary.org/obo/CHEBI_64924 hepatitis C protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670 protease inhibitor An inhibitor of hepatitis C protease, an enzyme required for production of proteins needed for viral assembly. http://purl.obolibrary.org/obo/CHEBI_66993 tocolytic agent http://purl.obolibrary.org/obo/CHEBI_50689 reproductive control drug Any compound used to suppress premature labour and immature birth by suppressing uterine contractions. http://purl.obolibrary.org/obo/CHEBI_67198 retinoic acid receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist An agonist that selectively binds to and activates a retinoic acid receptor. http://purl.obolibrary.org/obo/CHEBI_67199 AP-1 antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist An antogonist that interferes with the action of activator protein 1 (AP-1). http://purl.obolibrary.org/obo/CHEBI_71476 fatty acid synthase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits the enzyme fatty acid synthase (EC 2.3.1.85), a multi-enzyme protein involved in fatty acid synthesis. http://purl.obolibrary.org/obo/CHEBI_73182 plant activator http://purl.obolibrary.org/obo/CHEBI_33286 agrochemical Any compound that protects plants by activating their defence mechanisms. http://purl.obolibrary.org/obo/CHEBI_73336 vulnerary http://purl.obolibrary.org/obo/CHEBI_23888 drug A drug used in treating and healing of wounds. http://purl.obolibrary.org/obo/CHEBI_37886 adrenergic agonist http://purl.obolibrary.org/obo/CHEBI_37962 adrenergic agent An agent that selectively binds to and activates adrenergic receptors. http://purl.obolibrary.org/obo/CHEBI_39143 Lewis acid http://purl.obolibrary.org/obo/CHEBI_37527 acid A molecular entity that is an electron-pair acceptor and therefore able to form a covalent bond with an electron-pair donor (Lewis base), thereby producing a Lewis adduct. http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist A chemical substance which inhibits the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites. http://purl.obolibrary.org/obo/CHEBI_50507 appetite depressant http://purl.obolibrary.org/obo/CHEBI_50780 appetite regulator Agent that is used to decrease appetite. http://purl.obolibrary.org/obo/CHEBI_50745 progestogen http://purl.obolibrary.org/obo/CHEBI_50112 sex hormone A compound that interacts with progesterone receptors in target tissues to bring about effects similar to those of progesterone. http://purl.obolibrary.org/obo/CHEBI_51060 hormone agonist http://purl.obolibrary.org/obo/CHEBI_51061 hormone receptor modulator A chemical substance which binds to specific hormone receptors activating the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites. http://purl.obolibrary.org/obo/CHEBI_61950 microtubule-stabilising agent http://purl.obolibrary.org/obo/CHEBI_60832 tubulin modulator Any substance that interacts with tubulin to promote polymerisation of microtubules. http://purl.obolibrary.org/obo/CHEBI_64237 N-acetylglucosamine phosphotransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits any of the bacterial and eukaryote phosphotransferases, preventing formation of N-acetylglucosamine lipid intermediates and glycosylation of newly synthesised glycoproteins. http://purl.obolibrary.org/obo/CHEBI_64670 thioredoxin reductase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits thioredoxin reductase (EC 1.8.1.9) http://purl.obolibrary.org/obo/CHEBI_64857 cosmetic http://purl.obolibrary.org/obo/CHEBI_33232 application The role played by a substance in enhancing the appearance or odour of the human body; a name given to the substance itself or to a component of it. http://purl.obolibrary.org/obo/CHEBI_64995 arachidonate 12-lipoxygenase inhibitor http://purl.obolibrary.org/obo/CHEBI_35856 lipoxygenase inhibitor A lipoxygenase inhibitor that interferes with the action of arachidonate 12-lipoxygenase (EC 1.13.11.31). http://purl.obolibrary.org/obo/CHEBI_66991 sympatholytic agent http://purl.obolibrary.org/obo/CHEBI_37962 adrenergic agent Any compound which inhibits the postganglionic functioning of the sympathetic nervous system (SNS). http://purl.obolibrary.org/obo/CHEBI_75599 glutamate--cysteine ligase inhibitor http://purl.obolibrary.org/obo/CHEBI_59105 acid--amino-acid ligase inhibitor An acid--amino-acid ligase inhibitor that inhibits the action of a glutamate--cysteine ligase (EC 6.3.2.2) http://purl.obolibrary.org/obo/CHEBI_51374 GABA agent http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent A substance, such as agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function, used for its pharmacological actions on GABAergic systems. http://purl.obolibrary.org/obo/CHEBI_59727 vasopressin receptor agonist http://purl.obolibrary.org/obo/CHEBI_51060 hormone agonist Any drug which binds to vasopressin receptors and triggers a response. http://purl.obolibrary.org/obo/CHEBI_59745 chromatographic reagent http://purl.obolibrary.org/obo/CHEBI_33893 reagent A reagent used to improve selectivity in chromatographic analyses or separations, e.g. by formation of a derivative or by modification of the mobile phase. http://purl.obolibrary.org/obo/CHEBI_63090 purine nucleoside phosphorylase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of purine nucleoside phosphorylase. http://purl.obolibrary.org/obo/CHEBI_63963 metabotropic glutamate receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist An antagonist at the metabotropic glutamate receptor. http://purl.obolibrary.org/obo/CHEBI_64102 AMPA receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist An agonist that selectively binds to and activates AMPA receptors. http://purl.obolibrary.org/obo/CHEBI_64297 reaction intermediate http://purl.obolibrary.org/obo/CHEBI_51086 chemical role Any chemical substance produced during the conversion of a reactant to a product. http://purl.obolibrary.org/obo/CHEBI_64922 leukocyte elastase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits leukocyte elastase, EC 6.5.1.1. http://purl.obolibrary.org/obo/CHEBI_64926 serine protease inhibitor http://purl.obolibrary.org/obo/CHEBI_37670 protease inhibitor Any protease inhibitor that restricts the action of a serine protease. http://purl.obolibrary.org/obo/CHEBI_71338 autoinducer http://purl.obolibrary.org/obo/CHEBI_62488 signalling molecule A signalling molecule produced and used by bacteria participating in quorum sensing, that is, in cell-cell communication to coordinate community-wide regulation of processes such as biofilm formation, virulence, and bioluminescence in populations of bacteria. Such communication can occur both within and between different species of bacteria. http://purl.obolibrary.org/obo/CHEBI_72470 provitamin B1 http://purl.obolibrary.org/obo/CHEBI_50188 provitamin A provitamin that can be converted into vitamin B1 by enzymes from animal tissues. http://purl.obolibrary.org/obo/CHEBI_73267 oxidative phosphorylation inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor Any compound that inhibits oxidative phosphorylation. http://purl.obolibrary.org/obo/CHEBI_75380 catalase inhibitor http://purl.obolibrary.org/obo/CHEBI_75381 peroxidases inhibitor An inhibitor of peroxidases (EC 1.11.1.*) that inhibits the action of catalase (EC 1.11.1.6). http://purl.obolibrary.org/obo/CHEBI_59105 acid--amino-acid ligase inhibitor http://purl.obolibrary.org/obo/CHEBI_75600 C-N bond-forming ligase inhibitor Any inhibitor of an acid--amino-acid ligase (EC 6.3.2.*). http://purl.obolibrary.org/obo/CHEBI_59499 dipeptidase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any enzyme inhibitor that inhibits the action of a dipeptidase (EC 3.4.13.*). http://purl.obolibrary.org/obo/CHEBI_59752 bolaamphiphile http://purl.obolibrary.org/obo/CHEBI_35195 surfactant A surfactant molecule with hydrophilic groups at both ends of a hydrophobic hydrocarbon chain http://purl.obolibrary.org/obo/CHEBI_59864 depigmentation drug http://purl.obolibrary.org/obo/CHEBI_23888 drug Any drug used to depigment skin, normally by decreasing the excretion of melanin from melanocytes. http://purl.obolibrary.org/obo/CHEBI_59886 HIV fusion inhibitor http://purl.obolibrary.org/obo/CHEBI_64946 anti-HIV agent A drug which interferes with the binding, fusion and entry of an HIV virion to a human cell. By blocking this step in HIV's replication cycle, such agents slow the progression from HIV infection to AIDS. http://purl.obolibrary.org/obo/CHEBI_60218 mimotope http://purl.obolibrary.org/obo/CHEBI_24432 biological role Any macromolecule whose structure mimics that of an epitope. When applied to immunisation, a mimotope induces the desired antibody specificities exclusively based on the principle of molecular mimicry. http://purl.obolibrary.org/obo/CHEBI_60601 delta-opioid agent http://purl.obolibrary.org/obo/CHEBI_60598 opioid agent Any agent that acts on a delta-opioid receptor. http://purl.obolibrary.org/obo/CHEBI_60603 kappa-opioid agent http://purl.obolibrary.org/obo/CHEBI_60598 opioid agent Any agent that acts on a kappa-opioid receptor. http://purl.obolibrary.org/obo/CHEBI_60816 immunogen http://purl.obolibrary.org/obo/CHEBI_59132 antigen A type of antigen capable on its own of inducing an immune response. http://purl.obolibrary.org/obo/CHEBI_71942 phosphodiesterase V inhibitor http://purl.obolibrary.org/obo/CHEBI_50218 phosphodiesterase inhibitor A phosphodiesterase inhibitor that specifically blocks the action of phosphodiesterase V (EC 3.1.4.17). http://purl.obolibrary.org/obo/CHEBI_72316 virulence factor http://purl.obolibrary.org/obo/CHEBI_27026 toxin Any toxin secreted by bacteria, viruses, fungi or protozoa enabling them to achieve colonisation of a niche in the host, inhibit or evade the host's immune response, enter and exit cells, or obtain nutrition from the host. http://purl.obolibrary.org/obo/CHEBI_75600 C-N bond-forming ligase inhibitor http://purl.obolibrary.org/obo/CHEBI_75603 ligase inhibitor Any inhibitor of a C-N bond-forming ligase (EC 6.3.*.*). http://purl.obolibrary.org/obo/CHEBI_68481 mTOR inhibitor http://purl.obolibrary.org/obo/CHEBI_37699 protein kinase inhibitor A protein kinase inhibitor of mammalian target of rapamycin (mTOR), a protein that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis and transcription. They are used to prevent transplant rejection and in treatment of cancer. http://purl.obolibrary.org/obo/CHEBI_68509 glutathione depleting agent http://purl.obolibrary.org/obo/CHEBI_24432 biological role A compound which causes a reduction in the levels of glutathione in cells. http://purl.obolibrary.org/obo/CHEBI_68553 guanylate cyclase 2C agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist An agonist that selectively binds to and activates guanylate cyclase 2C receptors. http://purl.obolibrary.org/obo/CHEBI_68557 bradykinin receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist An antagonist at the bradykinin receptor. http://purl.obolibrary.org/obo/CHEBI_68581 coagulation factor Xa inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of coagulation factor Xa (EC 3.4.21.6) http://purl.obolibrary.org/obo/CHEBI_75282 ergosterol biosynthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor Any compound that inhibits one or more steps in the pathway leading to the synthesis of ergosterol. http://purl.obolibrary.org/obo/CHEBI_22586 antioxidant http://purl.obolibrary.org/obo/CHEBI_51086 chemical role A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. http://purl.obolibrary.org/obo/CHEBI_22587 antiviral agent http://purl.obolibrary.org/obo/CHEBI_33281 antimicrobial agent A substance that destroys or inhibits replication of viruses. http://purl.obolibrary.org/obo/CHEBI_23018 carbonic anhydrase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any enzyme inhibitor that inhibits the action of carbonic anhydrase, EC 4.2.1.1. Such compounds reduce the secretion of H(+) ions by the proximal kidney tubule. http://purl.obolibrary.org/obo/CHEBI_25212 metabolite http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role Any intermediate or product resulting from metabolism. http://purl.obolibrary.org/obo/CHEBI_33229 vitamin http://purl.obolibrary.org/obo/CHEBI_52211 physiological role An organic substance that is distributed in foodstuffs, is distinct from the main organic components of food (protein, carbohydrate and fat) and is needed for the normal nutrition of the organism in question. The term "vitamines" (from vita + amines) was coined in 1912 by Casimir Funk, who believed that these compounds were amines. http://purl.obolibrary.org/obo/CHEBI_33281 antimicrobial agent http://purl.obolibrary.org/obo/CHEBI_25944 pesticide A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. http://purl.obolibrary.org/obo/CHEBI_33282 antibacterial agent http://purl.obolibrary.org/obo/CHEBI_33281 antimicrobial agent A substance that kills or slows the growth of bacteria. http://purl.obolibrary.org/obo/CHEBI_33288 rodenticide http://purl.obolibrary.org/obo/CHEBI_25944 pesticide A substance used to destroy rodent pests. http://purl.obolibrary.org/obo/CHEBI_35221 antimetabolite http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization. http://purl.obolibrary.org/obo/CHEBI_35441 antiinfective agent http://purl.obolibrary.org/obo/CHEBI_23888 drug A substance used in the prophylaxis or therapy of infectious diseases. http://purl.obolibrary.org/obo/CHEBI_35470 central nervous system drug http://purl.obolibrary.org/obo/CHEBI_23888 drug A class of drugs producing both physiological and psychological effects through a variety of mechanisms involving the central nervous system. http://purl.obolibrary.org/obo/CHEBI_35471 psychotropic drug http://purl.obolibrary.org/obo/CHEBI_35470 central nervous system drug A loosely defined grouping of drugs that have effects on psychological function. http://purl.obolibrary.org/obo/CHEBI_35472 anti-inflammatory drug http://purl.obolibrary.org/obo/CHEBI_23888 drug A substance that reduces or suppresses inflammation. http://purl.obolibrary.org/obo/CHEBI_35474 anxiolytic drug http://purl.obolibrary.org/obo/CHEBI_35473 tranquilizing drug Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. http://purl.obolibrary.org/obo/CHEBI_35475 non-steroidal anti-inflammatory drug http://purl.obolibrary.org/obo/CHEBI_35842 antirheumatic drug An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. http://purl.obolibrary.org/obo/CHEBI_35476 antipsychotic agent http://purl.obolibrary.org/obo/CHEBI_35473 tranquilizing drug Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. http://purl.obolibrary.org/obo/CHEBI_35480 analgesic http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. http://purl.obolibrary.org/obo/CHEBI_35488 central nervous system depressant http://purl.obolibrary.org/obo/CHEBI_35470 central nervous system drug A loosely defined group of drugs that tend to reduce the activity of the central nervous system. http://purl.obolibrary.org/obo/CHEBI_35498 diuretic http://purl.obolibrary.org/obo/CHEBI_23888 drug An agent that promotes the excretion of urine through its effects on kidney function. http://purl.obolibrary.org/obo/CHEBI_35610 antineoplastic agent http://purl.obolibrary.org/obo/CHEBI_23888 drug A substance that inhibits or prevents the proliferation of neoplasms. http://purl.obolibrary.org/obo/CHEBI_35620 vasodilator agent http://purl.obolibrary.org/obo/CHEBI_35554 cardiovascular drug A drug used to cause dilation of the blood vessels. http://purl.obolibrary.org/obo/CHEBI_35623 anticonvulsant http://purl.obolibrary.org/obo/CHEBI_35488 central nervous system depressant A drug used to prevent seizures or reduce their severity. http://purl.obolibrary.org/obo/CHEBI_35674 antihypertensive agent http://purl.obolibrary.org/obo/CHEBI_35554 cardiovascular drug Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. http://purl.obolibrary.org/obo/CHEBI_35703 xenobiotic http://purl.obolibrary.org/obo/CHEBI_24432 biological role A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. http://purl.obolibrary.org/obo/CHEBI_35717 sedative http://purl.obolibrary.org/obo/CHEBI_35488 central nervous system depressant A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. http://purl.obolibrary.org/obo/CHEBI_35718 antifungal agent http://purl.obolibrary.org/obo/CHEBI_33281 antimicrobial agent An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce. Antifungal agents differ from industrial fungicides in that they defend against fungi present in human or animal tissues. http://purl.obolibrary.org/obo/CHEBI_35941 serotonergic agonist http://purl.obolibrary.org/obo/CHEBI_48278 serotonergic drug An agent that has an affinity for serotonin receptors and is able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. Serotonin agonists are used as antidepressants, anxiolytics, and in the treatment of migraine disorders. http://purl.obolibrary.org/obo/CHEBI_36044 antiviral drug http://purl.obolibrary.org/obo/CHEBI_36043 antimicrobial drug A substance used in the prophylaxis or therapy of virus diseases. http://purl.obolibrary.org/obo/CHEBI_36047 antibacterial drug http://purl.obolibrary.org/obo/CHEBI_36043 antimicrobial drug A drug used to treat or prevent bacterial infections. http://purl.obolibrary.org/obo/CHEBI_37890 alpha-adrenergic antagonist http://purl.obolibrary.org/obo/CHEBI_48539 alpha-adrenergic drug An agent that binds to but does not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous alpha-adrenergic agonists. alpha-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. http://purl.obolibrary.org/obo/CHEBI_37956 histamine antagonist http://purl.obolibrary.org/obo/CHEBI_37957 histaminergic drug Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. http://purl.obolibrary.org/obo/CHEBI_38215 calcium channel blocker http://purl.obolibrary.org/obo/CHEBI_38808 calcium channel modulator One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools. http://purl.obolibrary.org/obo/CHEBI_38325 muscarinic agonist http://purl.obolibrary.org/obo/CHEBI_38324 cholinergic agonist Any drug that binds to and activates a muscarinic cholinergic receptor. http://purl.obolibrary.org/obo/CHEBI_39456 antiglaucoma drug http://purl.obolibrary.org/obo/CHEBI_66981 ophthalmology drug Any drug which can be used to prevent or alleviate glaucoma, a disease in which the optic nerve is damaged, resulting in progressive, irreversible loss of vision. It is often, though not always, associated with increased pressure of the fluid in the eye. http://purl.obolibrary.org/obo/CHEBI_48279 serotonergic antagonist http://purl.obolibrary.org/obo/CHEBI_48278 serotonergic drug Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists. http://purl.obolibrary.org/obo/CHEBI_48422 angiogenesis inhibitor http://purl.obolibrary.org/obo/CHEBI_23888 drug An agent and endogenous substances that antagonize or inhibit the development of new blood vessels. http://purl.obolibrary.org/obo/CHEBI_48550 aldose reductase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits the action of aldose reductase (aldehyde reductase, EC 1.1.1.21). http://purl.obolibrary.org/obo/CHEBI_48561 dopaminergic antagonist http://purl.obolibrary.org/obo/CHEBI_48560 dopaminergic agent A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists. http://purl.obolibrary.org/obo/CHEBI_48876 muscarinic antagonist http://purl.obolibrary.org/obo/CHEBI_48873 cholinergic antagonist A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists. http://purl.obolibrary.org/obo/CHEBI_49159 leukotriene antagonist http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist A drug designed to prevent leukotriene synthesis or activity by blocking binding at the receptor level. http://purl.obolibrary.org/obo/CHEBI_49167 anti-asthmatic drug http://purl.obolibrary.org/obo/CHEBI_65023 anti-asthmatic agent A drug used to treat asthma. http://purl.obolibrary.org/obo/CHEBI_50176 keratolytic drug http://purl.obolibrary.org/obo/CHEBI_50177 dermatologic drug A drug that softens, separates, and causes desquamation of the cornified epithelium or horny layer of skin. Keratolytic drugs are used to expose mycelia of infecting fungi or to treat corns, warts, and certain other skin diseases. http://purl.obolibrary.org/obo/CHEBI_50183 P450 inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the activity of cytochrome P450 involved in catalysis of organic substances. http://purl.obolibrary.org/obo/CHEBI_50249 anticoagulant http://purl.obolibrary.org/obo/CHEBI_50248 hematologic agent An agent that prevents blood clotting. http://purl.obolibrary.org/obo/CHEBI_50267 protective agent http://purl.obolibrary.org/obo/CHEBI_23888 drug Synthetic or natural substance which is given to prevent a disease or disorder or are used in the process of treating a disease or injury due to a poisonous agent. http://purl.obolibrary.org/obo/CHEBI_50390 NAD(P)H:quinone oxidoreductase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Compound that inhibits the flavoprotein that reversibly catalyzes the oxidation of NADH or NADPH. http://purl.obolibrary.org/obo/CHEBI_50502 dihydropteroate synthetase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor A compound or agent that combines with dihydropteroate synthetase, an enzyme that catalyzes the formation of dihydropteroate from p-aminobenzoic acid and dihydropteridine-hydroxymethyl-pyrophosphate. http://purl.obolibrary.org/obo/CHEBI_50514 vasoconstrictor agent http://purl.obolibrary.org/obo/CHEBI_35554 cardiovascular drug Drug used to cause constriction of the blood vessels. http://purl.obolibrary.org/obo/CHEBI_50629 cyclooxygenase 2 inhibitor http://purl.obolibrary.org/obo/CHEBI_35544 cyclooxygenase inhibitor A cyclooxygenase inhibitor with specificity for cyclooxygenase 2. http://purl.obolibrary.org/obo/CHEBI_50750 topoisomerase II inhibitor http://purl.obolibrary.org/obo/CHEBI_70727 topoisomerase inhibitor A topoisomerase inhibitor that inhibits DNA topoisomerase II (EC 5.99.1.3), which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. http://purl.obolibrary.org/obo/CHEBI_50903 carcinogenic agent http://purl.obolibrary.org/obo/CHEBI_52209 aetiopathogenetic role A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities. http://purl.obolibrary.org/obo/CHEBI_50925 non-specific serine/threonine protein kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_37699 protein kinase inhibitor An agent that inhibits the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine. http://purl.obolibrary.org/obo/CHEBI_51373 GABA agonist http://purl.obolibrary.org/obo/CHEBI_51374 GABA agent A drug that binds to and activates gamma-aminobutyric acid receptors. http://purl.obolibrary.org/obo/CHEBI_53559 topoisomerase IV inhibitor http://purl.obolibrary.org/obo/CHEBI_70727 topoisomerase inhibitor A topoisomerase inhibitor that inhibits DNA topoisomerase IV, which catalyses ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks, and rejoining of the broken strands. http://purl.obolibrary.org/obo/CHEBI_53756 HIV-1 reverse transcriptase inhibitor http://purl.obolibrary.org/obo/CHEBI_59897 reverse transcriptase inhibitor An entity which inhibits the activity of HIV-1 reverse transcriptase. http://purl.obolibrary.org/obo/CHEBI_55347 vitamin K antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist A class of anticoagulants which act by inhibiting the action of vitamin K. http://purl.obolibrary.org/obo/CHEBI_59107 metalloendopeptidase inhibitor http://purl.obolibrary.org/obo/CHEBI_50664 matrix metalloproteinase inhibitor An inhibitor of any metalloendopeptidase (EC 3.4.24.*). http://purl.obolibrary.org/obo/CHEBI_59517 DNA synthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any substance that inhibits the synthesis of DNA. http://purl.obolibrary.org/obo/CHEBI_61908 nitric oxide synthase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits the action of nitric oxide synthase, EC 1.14.13.39. http://purl.obolibrary.org/obo/CHEBI_61966 metabotropic glutamate receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist An agonist that selectively binds to and activates a metabotropic glutamate receptor. http://purl.obolibrary.org/obo/CHEBI_62868 hepatoprotective agent http://purl.obolibrary.org/obo/CHEBI_50267 protective agent Any compound that is able to prevent damage to the liver. http://purl.obolibrary.org/obo/CHEBI_63726 neuroprotective agent http://purl.obolibrary.org/obo/CHEBI_50267 protective agent Any compound that can be used for the treatment of neurodegenerative disorders. http://purl.obolibrary.org/obo/CHEBI_64932 cathepsin B inhibitor http://purl.obolibrary.org/obo/CHEBI_64152 cysteine protease inhibitor A cysteine protease inhibitor which inhibits cathepsin B (EC 3.4.22.1). http://purl.obolibrary.org/obo/CHEBI_64964 arachidonate 5-lipoxygenase inhibitor http://purl.obolibrary.org/obo/CHEBI_35856 lipoxygenase inhibitor A lipoxygenase inhibitor that interferes with the action of arachidonate 5-lipoxygenase (EC 1.13.11.34). http://purl.obolibrary.org/obo/CHEBI_65023 anti-asthmatic agent http://purl.obolibrary.org/obo/CHEBI_33232 application Any compound that has anti-asthmatic effects. http://purl.obolibrary.org/obo/CHEBI_66981 ophthalmology drug http://purl.obolibrary.org/obo/CHEBI_23888 drug Any compound used for the treatment of eye conditions or eye diseases. http://purl.obolibrary.org/obo/CHEBI_67267 geranylgeranyltransferase type I inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of geranylgeranyltransferase type I (EC 2.5.1.59). http://purl.obolibrary.org/obo/CHEBI_68495 apoptosis inducer http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms. http://purl.obolibrary.org/obo/CHEBI_72483 vesicular glutamate transport inhibitor http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role An inhibitor that interferes with vesicular glutamate transport. http://purl.obolibrary.org/obo/CHEBI_74925 gamma-secretase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits the activity of gamma-secretase. http://purl.obolibrary.org/obo/CHEBI_75767 animal metabolite http://purl.obolibrary.org/obo/CHEBI_75763 eukaryotic metabolite Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to humans. http://purl.obolibrary.org/obo/CHEBI_75771 mouse metabolite http://purl.obolibrary.org/obo/CHEBI_75768 mammalian metabolite Any mammalian metabolite produced during a metabolic reaction in mouse (Mus musculus). http://purl.obolibrary.org/obo/CHEBI_23354 coenzyme http://purl.obolibrary.org/obo/CHEBI_23357 cofactor A low-molecular-weight, non-protein organic compound participating in enzymatic reactions as dissociable acceptor or donor of chemical groups or electrons. http://purl.obolibrary.org/obo/CHEBI_63247 reducing agent http://purl.obolibrary.org/obo/CHEBI_51086 chemical role The element or compound in a reduction-oxidation (redox) reaction that donates an electron to another species. http://purl.obolibrary.org/obo/CHEBI_64577 flour treatment agent http://purl.obolibrary.org/obo/CHEBI_64047 food additive A food additive which is added to flour to improve baking functionality. They include bleaching agents, oxidising agents and reducing agents. http://purl.obolibrary.org/obo/CHEBI_64996 arachidonate 15-lipoxygenase inhibitor http://purl.obolibrary.org/obo/CHEBI_35856 lipoxygenase inhibitor A lipoxygenase inhibitor that interferes with the action of arachidonate 15-lipoxygenase (EC 1.13.11.33). http://purl.obolibrary.org/obo/CHEBI_65001 triacylglycerol lipase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any compound that inhibits the action of triacylglycerol lipase (EC 3.1.1.3). http://purl.obolibrary.org/obo/CHEBI_65256 antimicrobial preservative http://purl.obolibrary.org/obo/CHEBI_33281 antimicrobial agent A food preservative which prevents decomposition of food by preventing the growth of fungi or bacteria. http://purl.obolibrary.org/obo/CHEBI_75763 eukaryotic metabolite http://purl.obolibrary.org/obo/CHEBI_25212 metabolite Any metabolite produced during a metabolic reaction in eukaryotes, the taxon that include members of the fungi, plantae and animalia kingdoms. http://purl.obolibrary.org/obo/CHEBI_25435 mutagen http://purl.obolibrary.org/obo/CHEBI_50902 genotoxin An agent that increases the frequency of mutations above the normal background level, usually by interacting directly with DNA and causing it damage, including base substitution. http://purl.obolibrary.org/obo/CHEBI_35442 antiparasitic agent http://purl.obolibrary.org/obo/CHEBI_35441 antiinfective agent A substance used to treat or prevent parasitic infections. http://purl.obolibrary.org/obo/CHEBI_50790 aromatase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor A compound that inhibits aromatase in order to reduce production of estrogenic steroid hormones. http://purl.obolibrary.org/obo/CHEBI_53000 epitope http://purl.obolibrary.org/obo/CHEBI_24432 biological role The biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds. http://purl.obolibrary.org/obo/CHEBI_35523 bronchodilator agent http://purl.obolibrary.org/obo/CHEBI_23888 drug An agent that causes an increase in the expansion of a bronchus or bronchial tubes. http://purl.obolibrary.org/obo/CHEBI_35640 adrenergic uptake inhibitor http://purl.obolibrary.org/obo/CHEBI_37962 adrenergic agent Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. http://purl.obolibrary.org/obo/CHEBI_38070 anti-arrhythmia drug http://purl.obolibrary.org/obo/CHEBI_35554 cardiovascular drug A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres. http://purl.obolibrary.org/obo/CHEBI_61115 histone deacetylase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the function of histone deacetylase (EC 3.5.1.98). http://purl.obolibrary.org/obo/CHEBI_63330 sodium-dependent Pi-transporter inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor Any substance that inhibits the action of sodium-dependent Pi-transporters. http://purl.obolibrary.org/obo/CHEBI_22676 auxin http://purl.obolibrary.org/obo/CHEBI_37848 plant hormone Any of a group of compounds, both naturally occurring and synthetic, that induce cell elongation in plant stems (from Greek alphaupsilonxialphanuomega, "to grow"). http://purl.obolibrary.org/obo/CHEBI_23240 chromophore http://purl.obolibrary.org/obo/CHEBI_52215 photochemical role The part (atom or group of atoms) of a molecular entity in which the electronic transition responsible for a given spectral band is approximately localized. http://purl.obolibrary.org/obo/CHEBI_25078 luciferin http://purl.obolibrary.org/obo/CHEBI_52216 photobiochemical role A low-molecular-mass compound present in bioluminescent organisms that emits light when oxidized in presence of enzyme luciferase. http://purl.obolibrary.org/obo/CHEBI_26115 phytoalexin http://purl.obolibrary.org/obo/CHEBI_38231 phytotoxin A toxin made by a plant that acts against an organism attacking it. http://purl.obolibrary.org/obo/CHEBI_26130 biological pigment http://purl.obolibrary.org/obo/CHEBI_52208 biophysical role An endogenous molecular entity that results in a colour of an organism as the consequence of the selective absorption of light. http://purl.obolibrary.org/obo/CHEBI_33287 fertilizer http://purl.obolibrary.org/obo/CHEBI_33286 agrochemical A fertilizer is any substance that is added to soil or water to assist the growth of plants. http://purl.obolibrary.org/obo/CHEBI_33295 diagnostic agent http://purl.obolibrary.org/obo/CHEBI_52217 pharmaceutical A substance administered to aid diagnosis of a disease. http://purl.obolibrary.org/obo/CHEBI_35230 fossil fuel http://purl.obolibrary.org/obo/CHEBI_33292 fuel A fuel such as coal, oil and natural gas which has formed over many years through the decomposition of deposited vegetation which was under extreme pressure of an overburden of earth. http://purl.obolibrary.org/obo/CHEBI_35487 aldehyde dehydrogenase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits the action of aldehyde dehydrogenase (EC 1.2.1.3). http://purl.obolibrary.org/obo/CHEBI_35608 protein tyrosine phosphatase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor which inhibits the activity of the enzyme protein tyrosine phosphatases (PTPs) involved in the removal of phosphate groups from phosphorylated tyrosine residues on proteins. http://purl.obolibrary.org/obo/CHEBI_35664 hydroxymethylglutaryl-CoA reductase inhibitor http://purl.obolibrary.org/obo/CHEBI_35821 anticholesteremic drug A compound that inhibits HMG-CoA reductases. Hydroxymethylglutaryl-CoA reductase inhibitors have been shown to lower directly cholesterol synthesis. http://purl.obolibrary.org/obo/CHEBI_35679 antilipemic drug http://purl.obolibrary.org/obo/CHEBI_23888 drug A substance used to treat hyperlipidemia (an excess of lipids in the blood). http://purl.obolibrary.org/obo/CHEBI_35821 anticholesteremic drug http://purl.obolibrary.org/obo/CHEBI_35679 antilipemic drug A substance used to lower plasma cholesterol levels. http://purl.obolibrary.org/obo/CHEBI_36043 antimicrobial drug http://purl.obolibrary.org/obo/CHEBI_35441 antiinfective agent A drug used to treat or prevent microbial infections. http://purl.obolibrary.org/obo/CHEBI_37733 cholinesterase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of cholinesterase (EC 3.1.1.8). http://purl.obolibrary.org/obo/CHEBI_37848 plant hormone http://purl.obolibrary.org/obo/CHEBI_24621 hormone A plant growth regulator that modulates the formation of stems, leaves and flowers, as well as the development and ripening of fruit. The term includes endogenous and non-endogenous compounds (e.g. active compounds produced by bacteria on the leaf surface) as well as semi-synthetic and fully synthetic compounds. http://purl.obolibrary.org/obo/CHEBI_37962 adrenergic agent http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter. http://purl.obolibrary.org/obo/CHEBI_46787 solvent http://purl.obolibrary.org/obo/CHEBI_51086 chemical role A liquid that can dissolve other substances (solutes) without any change in their chemical composition. http://purl.obolibrary.org/obo/CHEBI_48218 antiseptic drug http://purl.obolibrary.org/obo/CHEBI_35441 antiinfective agent A substance used locally on humans and other animals to destroy harmful microorganisms or to inhibit their activity (cf. disinfectants, which destroy microorganisms found on non-living objects, and antibiotics, which can be transported through the lymphatic system to destroy bacteria within the body). http://purl.obolibrary.org/obo/CHEBI_48219 disinfectant http://purl.obolibrary.org/obo/CHEBI_33281 antimicrobial agent A substance applied to non-living objects to destroy harmful microorganisms or to inhibit their activity. http://purl.obolibrary.org/obo/CHEBI_48354 polar solvent http://purl.obolibrary.org/obo/CHEBI_46787 solvent A solvent that is composed of polar molecules. Polar solvents can dissolve ionic compounds or ionisable covalent compounds. http://purl.obolibrary.org/obo/CHEBI_48407 antiparkinson drug http://purl.obolibrary.org/obo/CHEBI_66956 antidyskinesia agent A drug used in the treatment of Parkinson's disease. http://purl.obolibrary.org/obo/CHEBI_48560 dopaminergic agent http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons. http://purl.obolibrary.org/obo/CHEBI_49323 contraceptive drug http://purl.obolibrary.org/obo/CHEBI_50689 reproductive control drug A chemical substance that prevents or reduces the probability of conception. http://purl.obolibrary.org/obo/CHEBI_50248 hematologic agent http://purl.obolibrary.org/obo/CHEBI_23888 drug Drug that acts on blood and blood-forming organs and those that affect the hemostatic system. http://purl.obolibrary.org/obo/CHEBI_50276 topoisomerase I inhibitor http://purl.obolibrary.org/obo/CHEBI_70727 topoisomerase inhibitor A topoisomerase inhibitor that inhibits the bacterial enzymes of the DNA topoisomerases, Type I class (EC5.99.1.2) that catalyze ATP-independent breakage of one of the two strands of DNA, passage of the unbroken strand through the break, and rejoining of the broken strand. These bacterial enzymes reduce the topological stress in the DNA structure by relaxing negatively, but not positively, supercoiled DNA. http://purl.obolibrary.org/obo/CHEBI_50370 parasympatholytic http://purl.obolibrary.org/obo/CHEBI_48873 cholinergic antagonist Any cholinergic antagonist that inhibits the actions of the parasympathetic nervous system. The major group of drugs used therapeutically for this purpose is the muscarinic antagonists. http://purl.obolibrary.org/obo/CHEBI_50504 osmotic diuretic http://purl.obolibrary.org/obo/CHEBI_35498 diuretic Compound that increase urine volume by increasing the amount of osmotically active solute in the urine. It also increases the osmolarity of plasma. http://purl.obolibrary.org/obo/CHEBI_50505 sweetening agent http://purl.obolibrary.org/obo/CHEBI_35617 flavouring agent Substance that sweeten food, beverages, medications, etc. http://purl.obolibrary.org/obo/CHEBI_50513 mydriatic agent http://purl.obolibrary.org/obo/CHEBI_23888 drug Agent that dilates the pupil. Used in eye diseases and to facilitate eye examination. It may be either a sympathomimetic or parasympatholytic. The latter cause cycloplegia or paralysis of accommodation at high doses and may precipitate glaucoma. http://purl.obolibrary.org/obo/CHEBI_50696 penicillin binding protein 3 inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An agent that inhibits penicillin binding protein 3 (PBP3), a bacterial protein that binds irreversibly to penicillins and other antibacterial agents derived from lactams. The penicillin-binding proteins are primarily enzymes involved in cell wall biosynthesis. http://purl.obolibrary.org/obo/CHEBI_50847 immunological adjuvant http://purl.obolibrary.org/obo/CHEBI_50846 immunomodulator A substance that augments, stimulates, activates, potentiates, or modulates the immune response at either the cellular or humoral level. A classical agent (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contains bacterial antigens. It could also be endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Its mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy is related to its antigen-specific immunoadjuvanticity. http://purl.obolibrary.org/obo/CHEBI_52425 neuraminidase inhibitor http://purl.obolibrary.org/obo/CHEBI_36044 antiviral drug An antiviral drug targeted at influenza viruses. Its mode of action consists of blocking the function of the viral neuraminidase protein, thus preventing the virus from budding from the host cell. http://purl.obolibrary.org/obo/CHEBI_53746 inosine monophosphate dehydrogenase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An entity that blocks de novo biosynthesis of purine nucleotides by inhibition of the enzyme inosine monophosphate dehydrogenase. http://purl.obolibrary.org/obo/CHEBI_59647 serine C-palmitoyltransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any compound that inhibits the action of serine palmitoyltransferase (EC 2.3.1.50). http://purl.obolibrary.org/obo/CHEBI_59826 progestin http://purl.obolibrary.org/obo/CHEBI_50745 progestogen A synthetic progestogen. http://purl.obolibrary.org/obo/CHEBI_60606 opioid receptor agonist http://purl.obolibrary.org/obo/CHEBI_60598 opioid agent An agent that selectively binds to and activates an opioid receptor. http://purl.obolibrary.org/obo/CHEBI_60832 tubulin modulator http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role Any substance that interacts with tubulin to inhibit or promote polymerisation of microtubules. http://purl.obolibrary.org/obo/CHEBI_61951 microtubule-destabilising agent http://purl.obolibrary.org/obo/CHEBI_60832 tubulin modulator Any substance that interacts with tubulin to inhibit polymerisation of microtubules. http://purl.obolibrary.org/obo/CHEBI_62089 glutamate synthase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any compound that inhibits the action of glutamate synthase. http://purl.obolibrary.org/obo/CHEBI_62215 allelochemical http://purl.obolibrary.org/obo/CHEBI_26619 secondary metabolite A class of secondary metabolites developed by many plants to influence the behaviour, growth or survival of herbivores, and thus acting as a defence against herbivory. http://purl.obolibrary.org/obo/CHEBI_62913 poly(ADP-ribose) polymerase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits the action of a poly(ADP-ribose)polymerase. http://purl.obolibrary.org/obo/CHEBI_63332 alkaline phosphatase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of alkaline phosphatase. http://purl.obolibrary.org/obo/CHEBI_63490 explosive http://purl.obolibrary.org/obo/CHEBI_51086 chemical role A substance capable of undergoing rapid and highly exothermic decomposition. http://purl.obolibrary.org/obo/CHEBI_64018 protein kinase C agonist http://purl.obolibrary.org/obo/CHEBI_64106 protein kinase agonist An agonist that selectively binds to and activates a protein kinase C receptor http://purl.obolibrary.org/obo/CHEBI_65053 arginine decarboxylase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of arginine decarboxylase. http://purl.obolibrary.org/obo/CHEBI_65056 fructose-bisphosphatase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of fructose-bisphosphatase (EC 3.1.3.11). http://purl.obolibrary.org/obo/CHEBI_65057 adenosine A1 receptor agonist http://purl.obolibrary.org/obo/CHEBI_73311 adenosine receptor agonist An agonist at the A1 receptor. http://purl.obolibrary.org/obo/CHEBI_65064 cyclopropane fatty acid synthase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of cyclopropane fatty acid synthase. http://purl.obolibrary.org/obo/CHEBI_65065 DNA adenine methyltransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of DNA adenine methyltransferase. http://purl.obolibrary.org/obo/CHEBI_65207 vascular endothelial growth factor receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist An antagonist at the vascular endothelial growth factor receptor. http://purl.obolibrary.org/obo/CHEBI_65232 thrombin inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits the action of thrombin, EC 2.4.21.5. http://purl.obolibrary.org/obo/CHEBI_66956 antidyskinesia agent http://purl.obolibrary.org/obo/CHEBI_23888 drug Any compound which can be used to treat or alleviate the symptoms of dyskinesia. http://purl.obolibrary.org/obo/CHEBI_66980 nootropic agent http://purl.obolibrary.org/obo/CHEBI_23888 drug Any compound that improves mental functions such as cognition, memory, intelligence, motivation, attention, and concentration. http://purl.obolibrary.org/obo/CHEBI_68612 dipeptidyl peptidase-4 inhibitor http://purl.obolibrary.org/obo/CHEBI_60258 peptidase inhibitor A peptidase inhibitor that specifically inhibits dipeptidyl peptidase-4 (EC 3.4.14.5) http://purl.obolibrary.org/obo/CHEBI_70709 progesterone receptor agonist http://purl.obolibrary.org/obo/CHEBI_51060 hormone agonist A hormone agonist that binds to and activates progesterone receptors. http://purl.obolibrary.org/obo/CHEBI_70770 Aurora kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_37699 protein kinase inhibitor Any protein kinase inhibitor that inhibits the action of an Aurora kinase (a group of serine/threonine kinases that are essential for cell proliferation). http://purl.obolibrary.org/obo/CHEBI_71181 Sir2 inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of Sir2. http://purl.obolibrary.org/obo/CHEBI_71212 prohormone http://purl.obolibrary.org/obo/CHEBI_24432 biological role Any intra-glandular substance that acts as a precursor of a hormone, usually having minimal hormonal effect itself. Prohormones generally help in amplifying the effect of existing hormones. http://purl.obolibrary.org/obo/CHEBI_72854 indoleamine 2,3-dioxygenase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of indoleamine 2,3-dioxygenase (EC 1.13.11.52). http://purl.obolibrary.org/obo/CHEBI_73181 L-ascorbate peroxidase inhibitor http://purl.obolibrary.org/obo/CHEBI_75381 peroxidases inhibitor An inhibitor of peroxidases (EC 1.11.1.*) that inhibits the action of L-ascorbate peroxidase, EC 1.11.1.11. http://purl.obolibrary.org/obo/CHEBI_74529 antidote to paracetamol poisoning http://purl.obolibrary.org/obo/CHEBI_50247 antidote A role borne by a molecule that acts to counteract or neutralize the deleterious effects of paracetamol (acetaminophen). http://purl.obolibrary.org/obo/CHEBI_22695 base http://purl.obolibrary.org/obo/CHEBI_51086 chemical role A molecular entity having an available pair of electrons capable of forming a covalent bond with a hydron (Bronsted base) or with the vacant orbital of some other molecular entity (Lewis base). http://purl.obolibrary.org/obo/CHEBI_33292 fuel http://purl.obolibrary.org/obo/CHEBI_33232 application An energy-rich substance that can be transformed with release of usable energy. http://purl.obolibrary.org/obo/CHEBI_35544 cyclooxygenase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor A compound or agent that combines with cyclooxygenases and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes. http://purl.obolibrary.org/obo/CHEBI_35569 alpha-adrenergic agonist http://purl.obolibrary.org/obo/CHEBI_48539 alpha-adrenergic drug An agent that selectively binds to and activates alpha-adrenergic receptors. http://purl.obolibrary.org/obo/CHEBI_36413 anabolic agent http://purl.obolibrary.org/obo/CHEBI_24621 hormone A compound which stimulates anabolism and inhibits catabolism. Anabolic agents stimulate the development of muscle mass, strength, and power. http://purl.obolibrary.org/obo/CHEBI_38147 cardiotonic drug http://purl.obolibrary.org/obo/CHEBI_35554 cardiovascular drug A drug that has a strengthening effect on the heart or that can increase cardiac output. http://purl.obolibrary.org/obo/CHEBI_38637 tyrosine kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_37699 protein kinase inhibitor Any protein kinase inhibitor that interferes with the action of tyrosine kinase. http://purl.obolibrary.org/obo/CHEBI_38807 calcium channel agonist http://purl.obolibrary.org/obo/CHEBI_38808 calcium channel modulator Agents that increase calcium influx into calcium channels of excitable tissues. http://purl.obolibrary.org/obo/CHEBI_38808 calcium channel modulator http://purl.obolibrary.org/obo/CHEBI_38632 membrane transport modulator A membrane transport modulator that is able to regulate intracellular calcium levels. http://purl.obolibrary.org/obo/CHEBI_38941 schistosomicide drug http://purl.obolibrary.org/obo/CHEBI_35684 antiplatyhelmintic drug Drugs that used to treat infestations by flukes (trematodes) of the genus Schistosoma. http://purl.obolibrary.org/obo/CHEBI_39276 fumigant http://purl.obolibrary.org/obo/CHEBI_25944 pesticide A volatile or volatilizable chemical compound utilized for control of pests in buildings, soil, grain, as well as during processing of goods to be imported or exported to prevent transfer of exotic organisms. http://purl.obolibrary.org/obo/CHEBI_47867 indicator http://purl.obolibrary.org/obo/CHEBI_33232 application Anything used in a scientific experiment to indicate the presence of a substance or quality, change in a body, etc. http://purl.obolibrary.org/obo/CHEBI_48353 serine proteinase inhibitor http://purl.obolibrary.org/obo/CHEBI_37670 protease inhibitor An exogenous or endogenous compound which inhibits serine endopeptidases. http://purl.obolibrary.org/obo/CHEBI_48873 cholinergic antagonist http://purl.obolibrary.org/obo/CHEBI_38323 cholinergic drug Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists. http://purl.obolibrary.org/obo/CHEBI_48878 nicotinic antagonist http://purl.obolibrary.org/obo/CHEBI_48873 cholinergic antagonist An antagonist at the nicotinic cholinergic receptor. http://purl.obolibrary.org/obo/CHEBI_50671 antithyroid drug http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist A drug used to treat hyperthyroidism by reducing the excessive production of thyroid hormones. http://purl.obolibrary.org/obo/CHEBI_50684 cross-linking reagent http://purl.obolibrary.org/obo/CHEBI_33893 reagent A reagent with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between macromolecules, principally side chains of amino acids in proteins, allowing the locations of naturally reactive areas within the proteins to be identified. http://purl.obolibrary.org/obo/CHEBI_50748 antipsoriatic http://purl.obolibrary.org/obo/CHEBI_50177 dermatologic drug A drug used to treat psoriasis. http://purl.obolibrary.org/obo/CHEBI_50781 5alpha-reductase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Inhibitor of 5alpha-reductase, the enzyme which converts testosterone (CHEBI:17347) into the more potent androgen 5alpha-dihydrotestosterone. http://purl.obolibrary.org/obo/CHEBI_50846 immunomodulator http://purl.obolibrary.org/obo/CHEBI_23888 drug Biologically active substance whose activity affects or plays a role in the functioning of the immune system. http://purl.obolibrary.org/obo/CHEBI_50908 hepatotoxic agent http://purl.obolibrary.org/obo/CHEBI_52209 aetiopathogenetic role A role played by a chemical compound exihibiting itself through the ability to induce damage to the liver in animals. http://purl.obolibrary.org/obo/CHEBI_55323 antidiarrhoeal drug http://purl.obolibrary.org/obo/CHEBI_55324 gastrointestinal drug Any drug found useful in the symptomatic treatment of diarrhoea. http://purl.obolibrary.org/obo/CHEBI_62803 fuel additive http://purl.obolibrary.org/obo/CHEBI_51086 chemical role Any additive that enhances the efficiency of fuel. http://purl.obolibrary.org/obo/CHEBI_62873 odorant receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist An agonist that selectively binds to and activates an odorant receptor. http://purl.obolibrary.org/obo/CHEBI_63047 food emulsifier http://purl.obolibrary.org/obo/CHEBI_63046 emulsifier An emulsifier used in food manufacturing. http://purl.obolibrary.org/obo/CHEBI_63510 Na(+)/K(+)-transporting ATPase inhibitor http://purl.obolibrary.org/obo/CHEBI_49200 proton pump inhibitor Any acid anhydride hydrolase inhibitor that inhibits the action of Na(+)/K(+)-transporting ATPase (EC 3.6.3.9). http://purl.obolibrary.org/obo/CHEBI_64416 arogenate dehydrogenase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of arogenate dehydrogenase (EC 1.3.1.43). http://purl.obolibrary.org/obo/CHEBI_64477 monolignol http://purl.obolibrary.org/obo/CHEBI_26619 secondary metabolite A secondary metabolite of plant origin (phytochemical) which acting as a source material for biosynthesis of both lignans and lignin. http://purl.obolibrary.org/obo/CHEBI_64763 phosphatidylinositol-specific phospholipase C inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of phosphatidylinositol-specific phospholipase C. http://purl.obolibrary.org/obo/CHEBI_64951 anti-HBV agent http://purl.obolibrary.org/obo/CHEBI_22587 antiviral agent An antiviral agent that destroys or inhibits the replication of the hepatitis B virus. http://purl.obolibrary.org/obo/CHEBI_67195 gap junctional intercellular communication inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor An inhibitor that interferes with the process of gap junctional intercellular communication. http://purl.obolibrary.org/obo/CHEBI_70998 G-protein-coupled receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist An agonist that binds to and activates G-protein-coupled receptors http://purl.obolibrary.org/obo/CHEBI_73136 carbonyl reductase (NADPH) inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits the action of EC 1.1.1.184, carbonyl reductase (NADPH). http://purl.obolibrary.org/obo/CHEBI_74213 ribonucleoside-diphosphate reductase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits the action of ribonucleoside-diphosphate reductase (EC 1.17.4.1). http://purl.obolibrary.org/obo/CHEBI_75050 chromogenic compound http://purl.obolibrary.org/obo/CHEBI_50411 one-colour indicator Colourless, endogenous or exogenous pigment precursors that may be transformed by biological mechanisms into coloured compounds. They are used in biochemical assays and in diagnosis as indicators, particularly in the form of enzyme substrates. http://purl.obolibrary.org/obo/CHEBI_75325 cathartic http://purl.obolibrary.org/obo/CHEBI_52208 biophysical role Any substance that accelerates defecation. Compare with laxatives, which are substances that ease defecation (usually by softening faeces). A substance can be both a laxative and a cathartic. http://purl.obolibrary.org/obo/CHEBI_35660 HIV protease inhibitor http://purl.obolibrary.org/obo/CHEBI_64946 anti-HIV agent An inhibitor of HIV protease, an enzyme required for production of proteins needed for viral assembly. http://purl.obolibrary.org/obo/CHEBI_35678 histamine agonist http://purl.obolibrary.org/obo/CHEBI_37957 histaminergic drug A drug that binds to and activates histamine receptors. Although they have been suggested for a variety of clinical applications, histamine agonists have so far been more widely used in research than therapeutically. http://purl.obolibrary.org/obo/CHEBI_35684 antiplatyhelmintic drug http://purl.obolibrary.org/obo/CHEBI_35443 anthelminthic drug An agent used to treat cestode, trematode, or other flatworm infestations in man or animals. http://purl.obolibrary.org/obo/CHEBI_37887 adrenergic antagonist http://purl.obolibrary.org/obo/CHEBI_37962 adrenergic agent An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. http://purl.obolibrary.org/obo/CHEBI_48539 alpha-adrenergic drug http://purl.obolibrary.org/obo/CHEBI_37962 adrenergic agent Any drug that acts on an alpha-adrenergic receptor. http://purl.obolibrary.org/obo/CHEBI_48676 fibrin modulating drug http://purl.obolibrary.org/obo/CHEBI_23888 drug A drug that affects the function of fibrin in blood coagulation. http://purl.obolibrary.org/obo/CHEBI_49326 synthetic oral contraceptive http://purl.obolibrary.org/obo/CHEBI_49325 oral contraceptive An oral contraceptive which owes its effectiveness to synthetic preparation. http://purl.obolibrary.org/obo/CHEBI_50103 excitatory amino acid agonist http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent An agent that binds to and activates excitatory amino acid receptors. http://purl.obolibrary.org/obo/CHEBI_50241 cholinesterase reactivator http://purl.obolibrary.org/obo/CHEBI_50242 enzyme reactivator A drug used to reverse the inactivation of cholinesterase caused by organophosphates or sulfonates. http://purl.obolibrary.org/obo/CHEBI_50407 acid-base indicator http://purl.obolibrary.org/obo/CHEBI_50410 colour indicator An acid or base which exhibits a colour change on neutralization by the basic or acidic titrant at or near the equivalence point of a titration. http://purl.obolibrary.org/obo/CHEBI_50412 two-colour indicator http://purl.obolibrary.org/obo/CHEBI_50410 colour indicator A colour indicator that possesses a different colour on each side of the transition interval. http://purl.obolibrary.org/obo/CHEBI_50568 phosphodiesterase III inhibitor http://purl.obolibrary.org/obo/CHEBI_50218 phosphodiesterase inhibitor Compound which selectively inhibits or antagonizes the biosynthesis or actions of phosphodiesterase III (PDE3). http://purl.obolibrary.org/obo/CHEBI_50691 abortifacient http://purl.obolibrary.org/obo/CHEBI_50689 reproductive control drug A chemical substance that interrupts pregnancy after implantation. http://purl.obolibrary.org/obo/CHEBI_50739 estrogen receptor modulator http://purl.obolibrary.org/obo/CHEBI_23888 drug A substance that possess antiestrogenic actions but can also produce estrogenic effects as well. It acts as complete or partial agonist or as antagonist. It can be either steroidal or nonsteroidal in structure. http://purl.obolibrary.org/obo/CHEBI_50788 3beta-hydroxysteroid dehydrogenase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Inhibitor of 3beta-hydroxysteroid dehydrogenase (EC 1.1.1.210), a group of steroidogenic enzymes. http://purl.obolibrary.org/obo/CHEBI_50792 estrogen receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist An antagonist at the estrogen receptor. http://purl.obolibrary.org/obo/CHEBI_50837 estrogen antagonist http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist A compound which inhibits or antagonises the biosynthesis or actions of estrogens. http://purl.obolibrary.org/obo/CHEBI_50864 insulin-sensitizing drug http://purl.obolibrary.org/obo/CHEBI_70781 PPAR modulator An agent which overcomes insulin resistance by activation of the peroxisome proliferator activated receptor gamma (PPAR-gamma). http://purl.obolibrary.org/obo/CHEBI_50913 fixative http://purl.obolibrary.org/obo/CHEBI_24432 biological role A role played by a chemical compound or a mixture of chemical exhibiting itselef through the ability to cause tissue or entities derived from organism to become fixated to a surface or substratum. http://purl.obolibrary.org/obo/CHEBI_53353 GHB receptor agonist http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent A drug that binds to and activates gamma-hydroxybutyric acid receptors. http://purl.obolibrary.org/obo/CHEBI_53659 diamine oxidase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor A drug that has the ability to block oxidative deamination of naturally occurring diamines. http://purl.obolibrary.org/obo/CHEBI_59010 antiseborrheic http://purl.obolibrary.org/obo/CHEBI_50177 dermatologic drug A drug or agent applied to the skin to control seborrhea or seborrheic dermatitis. http://purl.obolibrary.org/obo/CHEBI_59229 GnRH antagonist http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist A chemical substance which inhibits the function of gonadotrophin-releasing hormone (GnRH). http://purl.obolibrary.org/obo/CHEBI_59282 kappa-opioid receptor agonist http://purl.obolibrary.org/obo/CHEBI_60606 opioid receptor agonist A compound that exhibits agonist activity at the kappa-opioid receptor. http://purl.obolibrary.org/obo/CHEBI_59283 delta-opioid receptor antagonist http://purl.obolibrary.org/obo/CHEBI_60601 delta-opioid agent A compound that exhibits antagonist activity at the delta-opioid receptor. http://purl.obolibrary.org/obo/CHEBI_59285 squalene monooxygenase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any inhibitor of squalene monooxygenase (EC 1.14.99.7). http://purl.obolibrary.org/obo/CHEBI_59321 aromatic-L-amino-acid decarboxylase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any inhibitor of an aromatic-L-amino-acid decarboxylase (EC 4.1.1.28). http://purl.obolibrary.org/obo/CHEBI_59680 vasopressin receptor antagonist http://purl.obolibrary.org/obo/CHEBI_62754 glycine receptor antagonist Any drug which blocks vasopressin receptors. http://purl.obolibrary.org/obo/CHEBI_59941 amphiphile http://purl.obolibrary.org/obo/CHEBI_35195 surfactant A surfactant molecule possessing both hydrophilic and lipophilic properties. http://purl.obolibrary.org/obo/CHEBI_60186 Ca(2+)-transporting ATPase inhibitor http://purl.obolibrary.org/obo/CHEBI_49200 proton pump inhibitor Any acid anhydride hydrolase inhibitor that inhibits the action of Ca(2+)-transporting ATPase (EC 3.6.3.8). http://purl.obolibrary.org/obo/CHEBI_62608 aconitase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the function of aconitase. http://purl.obolibrary.org/obo/CHEBI_65191 second generation antipsychotic http://purl.obolibrary.org/obo/CHEBI_35476 antipsychotic agent Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements. http://purl.obolibrary.org/obo/CHEBI_65265 antacid http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role Any substance which is used to neutralise stomach acidity. http://purl.obolibrary.org/obo/CHEBI_73263 cyclooxygenase 3 inhibitor http://purl.obolibrary.org/obo/CHEBI_35544 cyclooxygenase inhibitor A cyclooxygenase inhibitor with specificity for cyclooxygenase 3. http://purl.obolibrary.org/obo/CHEBI_73296 cholecystokinin antagonist http://purl.obolibrary.org/obo/CHEBI_49020 hormone antagonist A hormone antagonist that inhibits the action of the peptide hormone cholecystokinin. http://purl.obolibrary.org/obo/CHEBI_73333 scabicide http://purl.obolibrary.org/obo/CHEBI_22153 acaricide An acaricide that kills mites of the genus Sarcoptes. http://purl.obolibrary.org/obo/CHEBI_74352 quinol oxidation site inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor An compound that inhibits quinol oxidation sites. http://purl.obolibrary.org/obo/CHEBI_33290 food http://purl.obolibrary.org/obo/CHEBI_52211 physiological role Any material that can be ingested by an organism. http://purl.obolibrary.org/obo/CHEBI_35477 antimanic drug http://purl.obolibrary.org/obo/CHEBI_35473 tranquilizing drug Antimanic drugs are agents used to treat bipolar disorders or mania associated with other affective disorders. http://purl.obolibrary.org/obo/CHEBI_38706 pediculicide http://purl.obolibrary.org/obo/CHEBI_24852 insecticide Substance used to treat lice (genus Pediculus) infestation. http://purl.obolibrary.org/obo/CHEBI_50927 angiogenesis inducing agent http://purl.obolibrary.org/obo/CHEBI_50926 angiogenesis modulating agent An agent that induces or stimulates the physiologic angiogenesis process. http://purl.obolibrary.org/obo/CHEBI_60600 amide fungicide http://purl.obolibrary.org/obo/CHEBI_24127 fungicide Any member of the class of fungicides which contain an amide group. http://purl.obolibrary.org/obo/CHEBI_64370 glutamate transporter activator http://purl.obolibrary.org/obo/CHEBI_64371 neurotransmitter transporter modulator A neurotransmitter transporter modulator that activates glutamate transporters. http://purl.obolibrary.org/obo/CHEBI_71031 orphan drug http://purl.obolibrary.org/obo/CHEBI_23888 drug Any drug that has been developed specifically for treatment of a rare medical condition, the condition itself being known as an orphan disease. http://purl.obolibrary.org/obo/CHEBI_74236 polymerisation monomer http://purl.obolibrary.org/obo/CHEBI_51086 chemical role Any compound used as a monomer for a polymerisation process. The term is generally used in relation to industrial polymerisation processes. http://purl.obolibrary.org/obo/CHEBI_48406 catechol O-methyltransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any inhibitor of catechol O-methyltransferase, EC 2.1.1.6. http://purl.obolibrary.org/obo/CHEBI_48525 calcimimetic http://purl.obolibrary.org/obo/CHEBI_23888 drug A drug that it mimics the action of calcium on tissues. http://purl.obolibrary.org/obo/CHEBI_50184 ion transport inhibitor http://purl.obolibrary.org/obo/CHEBI_38632 membrane transport modulator A compound which inhibits the movement of an ion across an energy-transducing cell membrane. http://purl.obolibrary.org/obo/CHEBI_5924 serine endopeptidase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any inhibitor of a serine endopeptidase (EC 3.4.21.*). http://purl.obolibrary.org/obo/CHEBI_59844 antihyperplasia drug http://purl.obolibrary.org/obo/CHEBI_23888 drug A drug used for the treatment of hyperplasia (increaced cell production within an organ or tissue). http://purl.obolibrary.org/obo/CHEBI_63562 glucocorticoid receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist An agonist that selectively binds to and activates a glucocorticoid receptor. http://purl.obolibrary.org/obo/CHEBI_63923 sclerotherapy agent http://purl.obolibrary.org/obo/CHEBI_24432 biological role A sclerotherapy agent is used to treat blood vessels or blood vessel malformations (vascular malformations) and also those of the lymphatic system by injection into the vessels, which makes them shrink. http://purl.obolibrary.org/obo/CHEBI_64133 protein farnesyltransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Enzyme inhibitor of protein farnesyltransferase (EC 2.5.1.58), one of the three enzymes in the prenyltransferase group. http://purl.obolibrary.org/obo/CHEBI_64338 K-ATP channel agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist A compound which acts as an agonist at the ATP-sensitive K+ channel. http://purl.obolibrary.org/obo/CHEBI_68844 phosphodiesterase IV inhibitor http://purl.obolibrary.org/obo/CHEBI_50218 phosphodiesterase inhibitor A phosphodiesterase inhibitor that specifically blocks the action of phosphodiesterase IV. http://purl.obolibrary.org/obo/CHEBI_72773 carotogenesis inhibitor http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor Any inhibitor of the biosynthesis of carotenoids. http://purl.obolibrary.org/obo/CHEBI_72774 phytoene dehydrogenase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any compound that inhibits the action of phytoene dehydrogenase (phytoene desaturase), an enzyme of carotenoid biosynthesis that converts phytoene into zeta-carotene (zeta-carotene) via the symmetrical introduction of two double bonds at the C-11 and C-11' positions of phytoene. http://purl.obolibrary.org/obo/CHEBI_74136 lachrymator http://purl.obolibrary.org/obo/CHEBI_52208 biophysical role Any substance that stimulates the corneal nerves in the eves to cause tears. http://purl.obolibrary.org/obo/CHEBI_51076 antifouling biocide http://purl.obolibrary.org/obo/CHEBI_25944 pesticide A compound that inhibits the growth of marine organisms. http://purl.obolibrary.org/obo/CHEBI_51166 Wittig reagent http://purl.obolibrary.org/obo/CHEBI_33893 reagent A role played by a phosphonium ylide in a Wittig reaction. http://purl.obolibrary.org/obo/CHEBI_51237 Grignard reagent http://purl.obolibrary.org/obo/CHEBI_33893 reagent A role played by an organomagnesium halide in a Grignard reaction. http://purl.obolibrary.org/obo/CHEBI_51267 swelling agent http://purl.obolibrary.org/obo/CHEBI_33893 reagent A role played by a compound in a fluid state in swelling a gel, network, or solid. http://purl.obolibrary.org/obo/CHEBI_51268 drying control chemical additive http://purl.obolibrary.org/obo/CHEBI_46787 solvent A role played by a compound that facilitates the rapid drying of gels without their cracking. http://purl.obolibrary.org/obo/CHEBI_51451 endothelin receptor antagonist http://purl.obolibrary.org/obo/CHEBI_62754 glycine receptor antagonist A hormone antagonist that blocks endothelin receptors. http://purl.obolibrary.org/obo/CHEBI_51452 endothelin A receptor antagonist http://purl.obolibrary.org/obo/CHEBI_51451 endothelin receptor antagonist A endothelin receptor antagonist is a drug which selectively blocks endothelin A receptors. http://purl.obolibrary.org/obo/CHEBI_51577 partial prostacyclin agonist http://purl.obolibrary.org/obo/CHEBI_35620 vasodilator agent A compound which binds and activates the prostacyclin receptor IP1, but has only partial efficacy at the receptor relative to a full agonist. http://purl.obolibrary.org/obo/CHEBI_52271 squaraine dye http://purl.obolibrary.org/obo/CHEBI_51121 fluorescent dye An organic dye characterized by an aromatic four-membered ring system derived from squaric acid. http://purl.obolibrary.org/obo/CHEBI_52629 HIV-1 RNase H inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An inhibitor of ribonuclease H, an enzyme required for specific hydrolysis of the RNA strand of an RNA/DNA hybrid. http://purl.obolibrary.org/obo/CHEBI_52941 phosphate protecting group http://purl.obolibrary.org/obo/CHEBI_51087 protecting group A group that serves to protect a phosphate group in the context of a synthesis. http://purl.obolibrary.org/obo/CHEBI_52943 carboxylic acid protecting group http://purl.obolibrary.org/obo/CHEBI_51087 protecting group A group that serves to protect a carboxylic acid function in the context of a synthesis. http://purl.obolibrary.org/obo/CHEBI_53337 tissue adhesive http://purl.obolibrary.org/obo/CHEBI_24432 biological role A substance used to cause adherence of tissue to tissue or tissue to non-tissue surfaces, as for prostheses. http://purl.obolibrary.org/obo/CHEBI_63060 phase-transfer catalyst http://purl.obolibrary.org/obo/CHEBI_35223 catalyst A catalyst that facilitates the migration of a reactant from one phase into another phase where reaction occurs. http://purl.obolibrary.org/obo/CHEBI_67126 colorimetric reagent http://purl.obolibrary.org/obo/CHEBI_33893 reagent A reagent used in the determination of the concentration of a coloured chemical element or chemical compound in solution. http://purl.obolibrary.org/obo/CHEBI_72716 transglutaminase-2 inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of transglutaminase-2 (EC 2.3.2.13). http://purl.obolibrary.org/obo/CHEBI_73352 protein-sequencing agent http://purl.obolibrary.org/obo/CHEBI_33232 application Any agent used to determine the amino-acid sequence in a polypeptide. http://purl.obolibrary.org/obo/CHEBI_73354 creatine kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits the action of creatine kinase, EC 2.7.3.2. http://purl.obolibrary.org/obo/CHEBI_73618 spectrophotometric reagent http://purl.obolibrary.org/obo/CHEBI_33893 reagent A reagent used in the determination by spectrophotometry of the concentration of a chemical element or chemical compound in solution. http://purl.obolibrary.org/obo/CHEBI_73623 tolerogen http://purl.obolibrary.org/obo/CHEBI_24432 biological role A substance that invokes a specific immune non-responsiveness due to its molecular form. If its molecular form is changed, a tolerogen can become an immunogen. http://purl.obolibrary.org/obo/CHEBI_73668 peptide coupling reagent http://purl.obolibrary.org/obo/CHEBI_33893 reagent A reagent used to couple amino acids during artificial peptide synthesis. http://purl.obolibrary.org/obo/CHEBI_66894 erythropeotin receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist An agonist that binds to and activates erythropeotin receptors. http://purl.obolibrary.org/obo/CHEBI_66902 CFTR potentiator http://purl.obolibrary.org/obo/CHEBI_38632 membrane transport modulator A membrane transport modulator that restores the chloride ion transport ability of defective cystic fibrosis transmembrane conductance regulator (CFTR) genes. http://purl.obolibrary.org/obo/CHEBI_66908 SMO receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist An antagonist that interferes with the action of smoothened (SMO) receptor http://purl.obolibrary.org/obo/CHEBI_66921 Janus kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_38637 tyrosine kinase inhibitor A tyrosine kinase inhibitor that specifically blocks the action of Janus kinase. http://purl.obolibrary.org/obo/CHEBI_67072 cannabinoid receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist An agonist that binds to and activates cannabinoid receptors. http://purl.obolibrary.org/obo/CHEBI_67137 NMR shift reagent http://purl.obolibrary.org/obo/CHEBI_33893 reagent In NMR spectroscopy a reagent added to a solution to induce chemical shifts and thus simplify complex spectra. http://purl.obolibrary.org/obo/CHEBI_67170 anti-angiogenic agent http://purl.obolibrary.org/obo/CHEBI_50926 angiogenesis modulating agent Any compound that inhibits the growth of new blood vessels from pre-existing vessels. http://purl.obolibrary.org/obo/CHEBI_67189 microbial collagenase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor which inhibits the action of microbial collagenase (EC 3.4.24.3, also formerly EC 3.4.4.19 and EC 3.4.99.5) http://purl.obolibrary.org/obo/CHEBI_67230 glucosylceramidase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits the action of glucosylceramidase (EC 3.2.1.45). http://purl.obolibrary.org/obo/CHEBI_67231 sucrose alpha-glucosidase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits the action of sucrose alpha-glucosidase (EC 3.2.1.48). http://purl.obolibrary.org/obo/CHEBI_70821 cathepsin L inhibitor http://purl.obolibrary.org/obo/CHEBI_64152 cysteine protease inhibitor A cysteine protease inhibitor which inhibits cathepsin L (EC 3.4.22.15). http://purl.obolibrary.org/obo/CHEBI_70822 papain inhibitor http://purl.obolibrary.org/obo/CHEBI_64152 cysteine protease inhibitor A cysteine protease inhibitor which inhibits papain (EC 3.4.22.2). http://purl.obolibrary.org/obo/CHEBI_71951 peptide deformylase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of peptide deformylase (EC 3.5.1.88) involved in the catalytic removal of N-terminal formyl group of nascent proteins. http://purl.obolibrary.org/obo/CHEBI_72294 nerve growth factor stimulator http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent Any molecule shown to have the potentiality in stimulating the effect of nerve growth factor. http://purl.obolibrary.org/obo/CHEBI_73196 methionine gamma-lyase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of the enzyme methionine gamma-lyase (EC 4.4.1.11). http://purl.obolibrary.org/obo/CHEBI_73730 PPARbeta/delta agonist http://purl.obolibrary.org/obo/CHEBI_70781 PPAR modulator A PPAR modulator which activates the peroxisome proliferator-activated receptor-beta/delta. http://purl.obolibrary.org/obo/CHEBI_73911 vibriostatic agent http://purl.obolibrary.org/obo/CHEBI_33281 antimicrobial agent Any compound that inhibits the growth of bacteria of the genus Vibrio. http://purl.obolibrary.org/obo/CHEBI_74234 sepiapterin reductase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the activity of sepiapterin reductase (EC 1.1.1.153), which plays an important part in the biosynthesis of tetrahydrobiopterin. http://purl.obolibrary.org/obo/CHEBI_74520 NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of NADP(+)-dependent decarboxylating phosphogluconate dehydrogenase (EC 1.1.1.44). http://purl.obolibrary.org/obo/CHEBI_74570 gamma-glutamyltransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of gamma-glutamyltransferase (EC 2.3.2.2). http://purl.obolibrary.org/obo/CHEBI_74886 neoglycolipid probe http://purl.obolibrary.org/obo/CHEBI_33232 application A compound used as a probe during microarray analysis of oligosaccharide-protein interactions. http://purl.obolibrary.org/obo/CHEBI_74914 microarray analysis reagent http://purl.obolibrary.org/obo/CHEBI_33893 reagent A reagent used in the immobilization of compounds prior to their use in microarray analysis. http://purl.obolibrary.org/obo/CHEBI_74949 ribonuclease T1 inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interfers with the action of ribonuclease T1 (EC 3.1.27.3) http://purl.obolibrary.org/obo/CHEBI_75174 squalene synthase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of squalene synthase (EC 2.5.1.21). http://purl.obolibrary.org/obo/CHEBI_75252 insulin-like growth factor receptor 1 antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist An antagonist at the insulin-like growth factor receptor 1. http://purl.obolibrary.org/obo/CHEBI_75414 platelet-activating factor receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist An agonist that binds to and activates platelet-activating factor receptors. http://purl.obolibrary.org/obo/CHEBI_50444 adenosine phosphodiesterase inhibitor http://purl.obolibrary.org/obo/CHEBI_50218 phosphodiesterase inhibitor http://purl.obolibrary.org/obo/CHEBI_26087 photosynthetic electron-transport chain inhibitor http://purl.obolibrary.org/obo/CHEBI_38496 electron-transport chain inhibitor http://purl.obolibrary.org/obo/CHEBI_37700 protein kinase C inhibitor http://purl.obolibrary.org/obo/CHEBI_50925 non-specific serine/threonine protein kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_38060 triazine insecticide http://purl.obolibrary.org/obo/CHEBI_24852 insecticide http://purl.obolibrary.org/obo/CHEBI_24002 ethylene releasers http://purl.obolibrary.org/obo/CHEBI_26155 plant growth regulator http://purl.obolibrary.org/obo/CHEBI_51266 gelator http://purl.obolibrary.org/obo/CHEBI_33893 reagent http://purl.obolibrary.org/obo/CHEBI_38157 iron chelator http://purl.obolibrary.org/obo/CHEBI_38161 chelator http://purl.obolibrary.org/obo/CHEBI_38634 voltage-gated sodium channel blocker http://purl.obolibrary.org/obo/CHEBI_38633 sodium channel blocker http://purl.obolibrary.org/obo/CHEBI_38877 intravenous anaesthetic http://purl.obolibrary.org/obo/CHEBI_38869 general anaesthetic http://purl.obolibrary.org/obo/CHEBI_38870 inhalation anaesthetic http://purl.obolibrary.org/obo/CHEBI_38869 general anaesthetic http://purl.obolibrary.org/obo/CHEBI_48360 amphiprotic solvent http://purl.obolibrary.org/obo/CHEBI_48359 protophilic solvent http://purl.obolibrary.org/obo/CHEBI_50741 retinoic acid receptor alpha/beta agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist http://purl.obolibrary.org/obo/CHEBI_25605 nucleoside antibiotic http://purl.obolibrary.org/obo/CHEBI_22582 antibiotic http://purl.obolibrary.org/obo/CHEBI_39378 homopteran inhibitor of chitin biosynthesis http://purl.obolibrary.org/obo/CHEBI_23100 chitin synthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_52211 physiological role http://purl.obolibrary.org/obo/CHEBI_24432 biological role http://purl.obolibrary.org/obo/CHEBI_37958 dye http://purl.obolibrary.org/obo/CHEBI_33232 application http://purl.obolibrary.org/obo/CHEBI_50533 protein denaturant http://purl.obolibrary.org/obo/CHEBI_33232 application http://purl.obolibrary.org/obo/CHEBI_48278 serotonergic drug http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent http://purl.obolibrary.org/obo/CHEBI_25355 mitochondrial respiratory-chain inhibitor http://purl.obolibrary.org/obo/CHEBI_38497 respiratory-chain inhibitor http://purl.obolibrary.org/obo/CHEBI_38999 GABA-gated chloride channel antagonist http://purl.obolibrary.org/obo/CHEBI_38632 membrane transport modulator http://purl.obolibrary.org/obo/CHEBI_63054 osteogenesis regulator http://purl.obolibrary.org/obo/CHEBI_39317 growth regulator http://purl.obolibrary.org/obo/CHEBI_37337 ultrasound contrast agent http://purl.obolibrary.org/obo/CHEBI_37334 diagnostic imaging agent http://purl.obolibrary.org/obo/CHEBI_38500 mitochondrial cytochrome-c oxidase inhibitor http://purl.obolibrary.org/obo/CHEBI_25355 mitochondrial respiratory-chain inhibitor http://purl.obolibrary.org/obo/CHEBI_48359 protophilic solvent http://purl.obolibrary.org/obo/CHEBI_48354 polar solvent http://purl.obolibrary.org/obo/CHEBI_50664 matrix metalloproteinase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_50844 aldosterone antagonist http://purl.obolibrary.org/obo/CHEBI_50843 antimineralocorticoid http://purl.obolibrary.org/obo/CHEBI_50137 mu-opioid receptor antagonist http://purl.obolibrary.org/obo/CHEBI_60605 opioid receptor antagonist http://purl.obolibrary.org/obo/MP_0011324 abnormal kidney vasa recta morphology http://purl.obolibrary.org/obo/MP_0000530 abnormal kidney blood vessel morphology http://purl.obolibrary.org/obo/MP_0011149 abnormal hippocampus stratum lacunosum morphology http://purl.obolibrary.org/obo/MP_0000813 abnormal hippocampus layer morphology http://purl.obolibrary.org/obo/MP_0011150 abnormal hippocampus stratum oriens morphology http://purl.obolibrary.org/obo/MP_0000813 abnormal hippocampus layer morphology http://purl.obolibrary.org/obo/MP_0011151 abnormal hippocampus stratum radiatum morphology http://purl.obolibrary.org/obo/MP_0000813 abnormal hippocampus layer morphology http://purl.obolibrary.org/obo/MP_0013229 abnormal brain ventricle size http://purl.obolibrary.org/obo/MP_0000822 abnormal brain ventricle morphology http://purl.obolibrary.org/obo/MP_0011926 abnormal cardiac valve physiology http://purl.obolibrary.org/obo/MP_0001544 abnormal cardiovascular system physiology http://purl.obolibrary.org/obo/MP_0012230 abnormal sphingolipid level http://purl.obolibrary.org/obo/MP_0001547 abnormal lipid level http://purl.obolibrary.org/obo/MP_0010903 abnormal pulmonary alveolus wall morphology http://purl.obolibrary.org/obo/MP_0002270 abnormal pulmonary alveolus morphology http://purl.obolibrary.org/obo/MP_0011273 prolonged excitatory postsynaptic current decay time http://purl.obolibrary.org/obo/MP_0002910 abnormal excitatory postsynaptic currents http://purl.obolibrary.org/obo/MP_0011274 short excitatory postsynaptic current decay time http://purl.obolibrary.org/obo/MP_0002910 abnormal excitatory postsynaptic currents http://purl.obolibrary.org/obo/MP_0011329 abnormal inner renal medulla vasa recta morphology http://purl.obolibrary.org/obo/MP_0011324 abnormal kidney vasa recta morphology http://purl.obolibrary.org/obo/MP_0011152 thick hippocampus molecular cell layer http://purl.obolibrary.org/obo/MP_0008286 abnormal hippocampus molecular cell layer http://purl.obolibrary.org/obo/MP_0011153 thick hippocampus stratum oriens http://purl.obolibrary.org/obo/MP_0011150 abnormal hippocampus stratum oriens morphology http://purl.obolibrary.org/obo/MP_0011155 absent hippocampus stratum oriens http://purl.obolibrary.org/obo/MP_0011150 abnormal hippocampus stratum oriens morphology http://purl.obolibrary.org/obo/MP_0011154 thick hippocampus stratum radiatum http://purl.obolibrary.org/obo/MP_0011151 abnormal hippocampus stratum radiatum morphology http://purl.obolibrary.org/obo/MP_0011330 abnormal kidney outer medulla vasa recta morphology http://purl.obolibrary.org/obo/MP_0011332 abnormal kidney outer medulla morphology http://purl.obolibrary.org/obo/HP_0000118 Phenotypic abnormality http://purl.obolibrary.org/obo/HP_0000001 All http://purl.obolibrary.org/obo/HP_0000478 Abnormality of the eye http://purl.obolibrary.org/obo/HP_0000118 Phenotypic abnormality http://purl.obolibrary.org/obo/HP_0001626 Abnormality of the cardiovascular system http://purl.obolibrary.org/obo/HP_0000118 Phenotypic abnormality http://purl.obolibrary.org/obo/HP_0000707 Abnormality of the nervous system http://purl.obolibrary.org/obo/HP_0000118 Phenotypic abnormality http://purl.obolibrary.org/obo/HP_0012373 Abnormal eye physiology http://purl.obolibrary.org/obo/HP_0000478 Abnormality of the eye http://purl.obolibrary.org/obo/HP_0011025 Abnormality of cardiovascular system physiology http://purl.obolibrary.org/obo/HP_0001626 Abnormality of the cardiovascular system http://purl.obolibrary.org/obo/HP_0011675 Arrhythmia http://purl.obolibrary.org/obo/HP_0011025 Abnormality of cardiovascular system physiology http://purl.obolibrary.org/obo/HP_0000501 Glaucoma http://purl.obolibrary.org/obo/HP_0012373 Abnormal eye physiology http://purl.obolibrary.org/obo/HP_0100660 Dyskinesia http://purl.obolibrary.org/obo/HP_0100022 Abnormality of movement http://purl.obolibrary.org/obo/CHEBI_39369 pyrethroid ether acaricide http://purl.obolibrary.org/obo/CHEBI_22153 acaricide http://purl.obolibrary.org/obo/CHEBI_39412 bridged diphenyl acaricide http://purl.obolibrary.org/obo/CHEBI_22153 acaricide http://purl.obolibrary.org/obo/CHEBI_39259 pyrethroid ester acaricide http://purl.obolibrary.org/obo/CHEBI_22153 acaricide http://purl.obolibrary.org/obo/CHEBI_68640 cytochrome P450 17-alpha-hydroxylase/C17,20-lyase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_50185 fatty acid synthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_50445 adenosine deaminase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_50469 phospholipase A2 inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_62871 phenylalanine ammonia-lyase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_50269 alcohol dehydrogenase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_23366 compatible osmolytes http://purl.obolibrary.org/obo/CHEBI_25728 osmolyte http://purl.obolibrary.org/obo/CHEBI_27027 micronutrient http://purl.obolibrary.org/obo/CHEBI_33284 nutrient http://purl.obolibrary.org/obo/CHEBI_50855 antiatherogenic agent http://purl.obolibrary.org/obo/CHEBI_35554 cardiovascular drug http://purl.obolibrary.org/obo/CHEBI_52214 ligand http://purl.obolibrary.org/obo/CHEBI_51086 chemical role http://purl.obolibrary.org/obo/CHEBI_64054 delta-opioid receptor agonist http://purl.obolibrary.org/obo/CHEBI_60606 opioid receptor agonist http://purl.obolibrary.org/obo/HP_0100022 Abnormality of movement http://purl.obolibrary.org/obo/HP_0000707 Abnormality of the nervous system http://purl.obolibrary.org/obo/CHEBI_49103 drug metabolite http://purl.obolibrary.org/obo/CHEBI_25212 metabolite http://purl.obolibrary.org/obo/CHEBI_27314 water-soluble vitamin http://purl.obolibrary.org/obo/CHEBI_33229 vitamin http://purl.obolibrary.org/obo/CHEBI_24020 fat-soluble vitamin http://purl.obolibrary.org/obo/CHEBI_33229 vitamin http://purl.obolibrary.org/obo/CHEBI_66987 radiation protective agent http://purl.obolibrary.org/obo/CHEBI_50267 protective agent http://purl.obolibrary.org/obo/CHEBI_21241 vitamin C http://purl.obolibrary.org/obo/CHEBI_27314 water-soluble vitamin http://purl.obolibrary.org/obo/CHEBI_25747 oxidized luciferins http://purl.obolibrary.org/obo/CHEBI_25078 luciferin http://purl.obolibrary.org/obo/CHEBI_24937 jasmonates http://purl.obolibrary.org/obo/CHEBI_37848 plant hormone http://purl.obolibrary.org/obo/CHEBI_51121 fluorescent dye http://purl.obolibrary.org/obo/CHEBI_37958 dye http://purl.obolibrary.org/obo/CHEBI_48355 non-polar solvent http://purl.obolibrary.org/obo/CHEBI_46787 solvent http://purl.obolibrary.org/obo/CHEBI_48357 aprotic solvent http://purl.obolibrary.org/obo/CHEBI_46787 solvent http://purl.obolibrary.org/obo/CHEBI_48358 polar aprotic solvent http://purl.obolibrary.org/obo/CHEBI_48357 aprotic solvent http://purl.obolibrary.org/obo/GO_0004519 endonuclease activity http://purl.obolibrary.org/obo/GO_0004518 nuclease activity http://purl.obolibrary.org/obo/GO_0004521 endoribonuclease activity http://purl.obolibrary.org/obo/GO_0004540 ribonuclease activity http://purl.obolibrary.org/obo/GO_0004623 phospholipase A2 activity http://purl.obolibrary.org/obo/GO_0052689 carboxylic ester hydrolase activity http://purl.obolibrary.org/obo/GO_0004674 protein serine/threonine kinase activity http://purl.obolibrary.org/obo/GO_0004672 protein kinase activity http://purl.obolibrary.org/obo/GO_0004713 protein tyrosine kinase activity http://purl.obolibrary.org/obo/GO_0004672 protein kinase activity http://purl.obolibrary.org/obo/GO_0004697 protein kinase C activity http://purl.obolibrary.org/obo/GO_0004674 protein serine/threonine kinase activity http://purl.obolibrary.org/obo/GO_0004714 transmembrane receptor protein tyrosine kinase activity http://purl.obolibrary.org/obo/GO_0019199 transmembrane receptor protein kinase activity http://purl.obolibrary.org/obo/GO_0005007 fibroblast growth factor-activated receptor activity http://purl.obolibrary.org/obo/GO_0004714 transmembrane receptor protein tyrosine kinase activity http://purl.obolibrary.org/obo/GO_0005021 vascular endothelial growth factor-activated receptor activity http://purl.obolibrary.org/obo/GO_0004714 transmembrane receptor protein tyrosine kinase activity http://purl.obolibrary.org/obo/GO_0004725 protein tyrosine phosphatase activity http://purl.obolibrary.org/obo/GO_0004721 phosphoprotein phosphatase activity http://purl.obolibrary.org/obo/GO_0004954 prostanoid receptor activity http://purl.obolibrary.org/obo/GO_0004953 icosanoid receptor activity http://purl.obolibrary.org/obo/GO_0004971 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity http://purl.obolibrary.org/obo/GO_0004970 ionotropic glutamate receptor activity http://purl.obolibrary.org/obo/GO_0004972 N-methyl-D-aspartate selective glutamate receptor activity http://purl.obolibrary.org/obo/GO_0004970 ionotropic glutamate receptor activity http://purl.obolibrary.org/obo/GO_0005183 gonadotropin hormone-releasing hormone activity http://purl.obolibrary.org/obo/GO_0005179 hormone activity http://purl.obolibrary.org/obo/GO_0005326 neurotransmitter transporter activity http://purl.obolibrary.org/obo/GO_0005215 transporter activity http://purl.obolibrary.org/obo/GO_0005261 cation channel activity http://purl.obolibrary.org/obo/GO_0008324 cation transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0005218 intracellular ligand-gated calcium channel activity http://purl.obolibrary.org/obo/GO_0015278 calcium-release channel activity http://purl.obolibrary.org/obo/GO_0005219 ryanodine-sensitive calcium-release channel activity http://purl.obolibrary.org/obo/GO_0005218 intracellular ligand-gated calcium channel activity http://purl.obolibrary.org/obo/GO_0004970 ionotropic glutamate receptor activity http://purl.obolibrary.org/obo/GO_0008066 glutamate receptor activity http://purl.obolibrary.org/obo/GO_0005262 calcium channel activity http://purl.obolibrary.org/obo/GO_0015085 calcium ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0005267 potassium channel activity http://purl.obolibrary.org/obo/GO_0015079 potassium ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0005272 sodium channel activity http://purl.obolibrary.org/obo/GO_0015081 sodium ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0005623 cell http://purl.obolibrary.org/obo/GO_0005575 cellular_component http://purl.obolibrary.org/obo/GO_0006023 aminoglycan biosynthetic process http://purl.obolibrary.org/obo/GO_1901566 organonitrogen compound biosynthetic process http://purl.obolibrary.org/obo/GO_0006030 chitin metabolic process http://purl.obolibrary.org/obo/GO_1901071 glucosamine-containing compound metabolic process http://purl.obolibrary.org/obo/GO_0006031 chitin biosynthetic process http://purl.obolibrary.org/obo/GO_1901073 glucosamine-containing compound biosynthetic process http://purl.obolibrary.org/obo/GO_0006195 purine nucleotide catabolic process http://purl.obolibrary.org/obo/GO_0072523 purine-containing compound catabolic process http://purl.obolibrary.org/obo/GO_0006264 mitochondrial DNA replication http://purl.obolibrary.org/obo/GO_0032042 mitochondrial DNA metabolic process http://purl.obolibrary.org/obo/GO_0006305 DNA alkylation http://purl.obolibrary.org/obo/GO_0006304 DNA modification http://purl.obolibrary.org/obo/GO_0006306 DNA methylation http://purl.obolibrary.org/obo/GO_0043414 macromolecule methylation http://purl.obolibrary.org/obo/GO_0006650 glycerophospholipid metabolic process http://purl.obolibrary.org/obo/GO_0046486 glycerolipid metabolic process http://purl.obolibrary.org/obo/GO_0006139 nucleobase-containing compound metabolic process http://purl.obolibrary.org/obo/GO_1901360 organic cyclic compound metabolic process http://purl.obolibrary.org/obo/GO_0006796 phosphate-containing compound metabolic process http://purl.obolibrary.org/obo/GO_0006793 phosphorus metabolic process http://purl.obolibrary.org/obo/GO_0006644 phospholipid metabolic process http://purl.obolibrary.org/obo/GO_0044255 cellular lipid metabolic process http://purl.obolibrary.org/obo/GO_0006753 nucleoside phosphate metabolic process http://purl.obolibrary.org/obo/GO_0055086 nucleobase-containing small molecule metabolic process http://purl.obolibrary.org/obo/GO_0006812 cation transport http://purl.obolibrary.org/obo/GO_0006811 ion transport http://purl.obolibrary.org/obo/GO_0006820 anion transport http://purl.obolibrary.org/obo/GO_0006811 ion transport http://purl.obolibrary.org/obo/GO_0006807 nitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_0008152 metabolic process http://purl.obolibrary.org/obo/GO_0004660 protein farnesyltransferase activity http://purl.obolibrary.org/obo/GO_0008318 protein prenyltransferase activity http://purl.obolibrary.org/obo/GO_0005391 sodium:potassium-exchanging ATPase activity http://purl.obolibrary.org/obo/GO_0015081 sodium ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0006163 purine nucleotide metabolic process http://purl.obolibrary.org/obo/GO_0072521 purine-containing compound metabolic process http://purl.obolibrary.org/obo/GO_0006200 ATP catabolic process http://purl.obolibrary.org/obo/GO_0046130 purine ribonucleoside catabolic process http://purl.obolibrary.org/obo/GO_0006152 purine nucleoside catabolic process http://purl.obolibrary.org/obo/GO_0072523 purine-containing compound catabolic process http://purl.obolibrary.org/obo/GO_0006417 regulation of translation http://purl.obolibrary.org/obo/GO_2000112 regulation of cellular macromolecule biosynthetic process http://purl.obolibrary.org/obo/GO_0005216 ion channel activity http://purl.obolibrary.org/obo/GO_0022838 substrate-specific channel activity http://purl.obolibrary.org/obo/GO_0005388 calcium-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0019829 cation-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0005217 intracellular ligand-gated ion channel activity http://purl.obolibrary.org/obo/GO_0015276 ligand-gated ion channel activity http://purl.obolibrary.org/obo/GO_0005230 extracellular ligand-gated ion channel activity http://purl.obolibrary.org/obo/GO_0015276 ligand-gated ion channel activity http://purl.obolibrary.org/obo/GO_0006813 potassium ion transport http://purl.obolibrary.org/obo/GO_0030001 metal ion transport http://purl.obolibrary.org/obo/GO_0004556 alpha-amylase activity http://purl.obolibrary.org/obo/GO_0016160 amylase activity http://purl.obolibrary.org/obo/GO_0004620 phospholipase activity http://purl.obolibrary.org/obo/GO_0016298 lipase activity http://purl.obolibrary.org/obo/GO_0006470 protein dephosphorylation http://purl.obolibrary.org/obo/GO_0006464 cellular protein modification process http://purl.obolibrary.org/obo/GO_0004758 serine C-palmitoyltransferase activity http://purl.obolibrary.org/obo/GO_0016454 C-palmitoyltransferase activity http://purl.obolibrary.org/obo/GO_0004968 gonadotropin-releasing hormone receptor activity http://purl.obolibrary.org/obo/GO_0016500 protein-hormone receptor activity http://purl.obolibrary.org/obo/GO_0004511 tyrosine 3-monooxygenase activity http://purl.obolibrary.org/obo/GO_0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen http://purl.obolibrary.org/obo/GO_0004503 monophenol monooxygenase activity http://purl.obolibrary.org/obo/GO_0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen http://purl.obolibrary.org/obo/GO_0004855 xanthine oxidase activity http://purl.obolibrary.org/obo/GO_0016727 oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor http://purl.obolibrary.org/obo/GO_0004518 nuclease activity http://purl.obolibrary.org/obo/GO_0016788 hydrolase activity, acting on ester bonds http://purl.obolibrary.org/obo/GO_0004523 ribonuclease H activity http://purl.obolibrary.org/obo/GO_0016891 endoribonuclease activity, producing 5'-phosphomonoesters http://purl.obolibrary.org/obo/GO_0006582 melanin metabolic process http://purl.obolibrary.org/obo/GO_0044763 single-organism cellular process http://purl.obolibrary.org/obo/GO_0006140 regulation of nucleotide metabolic process http://purl.obolibrary.org/obo/GO_0019220 regulation of phosphate metabolic process http://purl.obolibrary.org/obo/GO_0005743 mitochondrial inner membrane http://purl.obolibrary.org/obo/GO_0031966 mitochondrial membrane http://purl.obolibrary.org/obo/GO_0005243 gap junction channel activity http://purl.obolibrary.org/obo/GO_0022829 wide pore channel activity http://purl.obolibrary.org/obo/GO_0005740 mitochondrial envelope http://purl.obolibrary.org/obo/GO_0044429 mitochondrial part http://purl.obolibrary.org/obo/GO_0004799 thymidylate synthase activity http://purl.obolibrary.org/obo/GO_0042083 5,10-methylenetetrahydrofolate-dependent methyltransferase activity http://purl.obolibrary.org/obo/GO_0006586 indolalkylamine metabolic process http://purl.obolibrary.org/obo/GO_0006576 cellular biogenic amine metabolic process http://purl.obolibrary.org/obo/GO_0006022 aminoglycan metabolic process http://purl.obolibrary.org/obo/GO_1901564 organonitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_0006304 DNA modification http://purl.obolibrary.org/obo/GO_0006259 DNA metabolic process http://purl.obolibrary.org/obo/GO_0006073 cellular glucan metabolic process http://purl.obolibrary.org/obo/GO_0044264 cellular polysaccharide metabolic process http://purl.obolibrary.org/obo/GO_0005975 carbohydrate metabolic process http://purl.obolibrary.org/obo/GO_0071704 organic substance metabolic process http://purl.obolibrary.org/obo/GO_0006629 lipid metabolic process http://purl.obolibrary.org/obo/GO_0071704 organic substance metabolic process http://purl.obolibrary.org/obo/GO_0006082 organic acid metabolic process http://purl.obolibrary.org/obo/GO_0044763 single-organism cellular process http://purl.obolibrary.org/obo/GO_0005746 mitochondrial respiratory chain http://purl.obolibrary.org/obo/GO_0070469 respiratory chain http://purl.obolibrary.org/obo/GO_0005750 mitochondrial respiratory chain complex III http://purl.obolibrary.org/obo/GO_0045275 respiratory chain complex III http://purl.obolibrary.org/obo/GO_0006811 ion transport http://purl.obolibrary.org/obo/GO_0044765 single-organism transport http://purl.obolibrary.org/obo/GO_0006818 hydrogen transport http://purl.obolibrary.org/obo/GO_0044765 single-organism transport http://purl.obolibrary.org/obo/GO_0006810 transport http://purl.obolibrary.org/obo/GO_0051234 establishment of localization http://purl.obolibrary.org/obo/GO_0006109 regulation of carbohydrate metabolic process http://purl.obolibrary.org/obo/GO_0080090 regulation of primary metabolic process http://purl.obolibrary.org/obo/GO_0006040 amino sugar metabolic process http://purl.obolibrary.org/obo/GO_1901135 carbohydrate derivative metabolic process http://purl.obolibrary.org/obo/GO_0006275 regulation of DNA replication http://purl.obolibrary.org/obo/GO_0051052 regulation of DNA metabolic process http://purl.obolibrary.org/obo/CHEBI_62754 glycine receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist http://purl.obolibrary.org/obo/GO_0005215 transporter activity http://purl.obolibrary.org/obo/GO_0003674 molecular_function http://purl.obolibrary.org/obo/GO_0004883 glucocorticoid receptor activity http://purl.obolibrary.org/obo/GO_0003707 steroid hormone receptor activity http://purl.obolibrary.org/obo/GO_0005057 receptor signaling protein activity http://purl.obolibrary.org/obo/GO_0004871 signal transducer activity http://purl.obolibrary.org/obo/GO_0004887 thyroid hormone receptor activity http://purl.obolibrary.org/obo/GO_0038023 signaling receptor activity http://purl.obolibrary.org/obo/GO_0004984 olfactory receptor activity http://purl.obolibrary.org/obo/GO_0004888 transmembrane signaling receptor activity http://purl.obolibrary.org/obo/GO_0004900 erythropoietin receptor activity http://purl.obolibrary.org/obo/GO_0004896 cytokine receptor activity http://purl.obolibrary.org/obo/GO_0004949 cannabinoid receptor activity http://purl.obolibrary.org/obo/GO_0004930 G-protein coupled receptor activity http://purl.obolibrary.org/obo/GO_0004953 icosanoid receptor activity http://purl.obolibrary.org/obo/GO_0004930 G-protein coupled receptor activity http://purl.obolibrary.org/obo/GO_0005119 smoothened binding http://purl.obolibrary.org/obo/GO_0005102 receptor binding http://purl.obolibrary.org/obo/GO_0005179 hormone activity http://purl.obolibrary.org/obo/GO_0005102 receptor binding http://purl.obolibrary.org/obo/GO_0006261 DNA-dependent DNA replication http://purl.obolibrary.org/obo/GO_0006260 DNA replication http://purl.obolibrary.org/obo/GO_0004967 glucagon receptor activity http://purl.obolibrary.org/obo/GO_0008528 G-protein coupled peptide receptor activity http://purl.obolibrary.org/obo/GO_0005000 vasopressin receptor activity http://purl.obolibrary.org/obo/GO_0008528 G-protein coupled peptide receptor activity http://purl.obolibrary.org/obo/GO_0006817 phosphate ion transport http://purl.obolibrary.org/obo/GO_0015698 inorganic anion transport http://purl.obolibrary.org/obo/GO_0004558 alpha-glucosidase activity http://purl.obolibrary.org/obo/GO_0015926 glucosidase activity http://purl.obolibrary.org/obo/GO_0004672 protein kinase activity http://purl.obolibrary.org/obo/GO_0016773 phosphotransferase activity, alcohol group as acceptor http://purl.obolibrary.org/obo/GO_0004497 monooxygenase activity http://purl.obolibrary.org/obo/GO_0016491 oxidoreductase activity http://purl.obolibrary.org/obo/GO_0004506 squalene monooxygenase activity http://purl.obolibrary.org/obo/GO_0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen http://purl.obolibrary.org/obo/GO_0004517 nitric-oxide synthase activity http://purl.obolibrary.org/obo/GO_0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen http://purl.obolibrary.org/obo/GO_0004731 purine-nucleoside phosphorylase activity http://purl.obolibrary.org/obo/GO_0016763 transferase activity, transferring pentosyl groups http://purl.obolibrary.org/obo/GO_0004746 riboflavin synthase activity http://purl.obolibrary.org/obo/GO_0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups http://purl.obolibrary.org/obo/GO_0004721 phosphoprotein phosphatase activity http://purl.obolibrary.org/obo/GO_0016791 phosphatase activity http://purl.obolibrary.org/obo/GO_0004834 tryptophan synthase activity http://purl.obolibrary.org/obo/GO_0016836 hydro-lyase activity http://purl.obolibrary.org/obo/GO_0006476 protein deacetylation http://purl.obolibrary.org/obo/GO_0035601 protein deacylation http://purl.obolibrary.org/obo/GO_0005856 cytoskeleton http://purl.obolibrary.org/obo/GO_0043232 intracellular non-membrane-bounded organelle http://purl.obolibrary.org/obo/GO_0005874 microtubule http://purl.obolibrary.org/obo/GO_0044430 cytoskeletal part http://purl.obolibrary.org/obo/GO_0006091 generation of precursor metabolites and energy http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process http://purl.obolibrary.org/obo/GO_0006725 cellular aromatic compound metabolic process http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process http://purl.obolibrary.org/obo/GO_0006793 phosphorus metabolic process http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process http://purl.obolibrary.org/obo/CHEBI_50906 role A role is particular behaviour which a material entity may exhibit. http://purl.obolibrary.org/obo/MP_0000002 obsolete Morphology OBSOLETE. http://purl.obolibrary.org/obo/MP_0000012 obsolete loss of subcutaneous adipose tissue OBSOLETE. reduction in amount or absence of adipose tissue beneath the skin http://purl.obolibrary.org/obo/MP_0000027 obsolete horizontal canal defects OBSOLETE. http://purl.obolibrary.org/obo/MP_0000038 obsolete thin semicircular canals OBSOLETE. decreased diameter of the three long bony tubes of the labyrinth that are involved in the sense of balance http://purl.obolibrary.org/obo/MP_0000047 obsolete abnormal interdental cells OBSOLETE. http://purl.obolibrary.org/obo/MP_0000051 obsolete absent process brevus OBSOLETE. http://purl.obolibrary.org/obo/MP_0000142 obsolete An Extra Piece of Bone Rostral to C1 OBSOLETE. http://purl.obolibrary.org/obo/MP_0000143 obsolete Broadening/Splitting of the Neural Arch of C2 OBSOLETE. http://purl.obolibrary.org/obo/MP_0000148 obsolete abnormal shoulder/ pelvic girdle morphology OBSOLETE. any structural anomaly of the bones of the shoulder or of the bones of the pelvis by which the limbs attach to the axial skeleton http://purl.obolibrary.org/obo/MP_0000156 obsolete Presence of 6 Vertebrosternal Ribs instead of 7 OBSOLETE. http://purl.obolibrary.org/obo/MP_0000176 obsolete bone marrow occupied by adipocytes OBSOLETE. anomalous appearance of fat-forming cells in the bone marrow http://purl.obolibrary.org/obo/MP_0000237 obsolete decreased blood cell number OBSOLETE. fewer than the normal numbers of the various types of blood cells http://purl.obolibrary.org/obo/MP_0000247 obsolete abnormal interleukin-10 physiology OBSOLETE. functional anomaly of this factor that is a co-regulator of mast cell growth and produced by T and B cells http://purl.obolibrary.org/obo/MP_0000268 obsolete abnormal anterior cardiac development OBSOLETE. http://purl.obolibrary.org/obo/MP_0000306 obsolete abnormal pulse OBSOLETE. http://purl.obolibrary.org/obo/MP_0000307 obsolete abnormal heart sounds OBSOLETE. http://purl.obolibrary.org/obo/MP_0000317 obsolete abnormal cell number OBSOLETE. any anomaly in the numbers of cells http://purl.obolibrary.org/obo/MP_0000318 obsolete increased cell number OBSOLETE. greater than expected number of cells http://purl.obolibrary.org/obo/MP_0000319 obsolete increased activated B cell number OBSOLETE. http://purl.obolibrary.org/obo/MP_0000329 obsolete decreased cell number OBSOLETE. fewer than expected number of cells http://purl.obolibrary.org/obo/MP_0000330 obsolete decreased activated B cell number OBSOLETE. http://purl.obolibrary.org/obo/MP_0000340 obsolete absence of cell OBSOLETE. http://purl.obolibrary.org/obo/MP_0000353 obsolete Abnormal Cell Size OBSOLETE. http://purl.obolibrary.org/obo/MP_0000354 obsolete Increased Cell Size OBSOLETE. http://purl.obolibrary.org/obo/MP_0000355 obsolete Increased Purkinje Cell Size OBSOLETE. http://purl.obolibrary.org/obo/MP_0000356 obsolete Decreased Cell Size OBSOLETE. http://purl.obolibrary.org/obo/MP_0000357 obsolete Decreased Purkinje Cell Size OBSOLETE. http://purl.obolibrary.org/obo/MP_0000360 obsolete absent metachromatic granules OBSOLETE. lack of intracellular storage compartments that stain a different color than that of the dye used http://purl.obolibrary.org/obo/MP_0000363 obsolete Abnormal Cell Behavior OBSOLETE. http://purl.obolibrary.org/obo/MP_0000365 obsolete Abnormal Hematopoietic/Hemopoietic/ Hematogenic/Hemogenic/Sanguifacient Cell Behavior OBSOLETE. http://purl.obolibrary.org/obo/MP_0000366 obsolete Impaired Proliferative Response of Hematopoietic Cells to Mitogens OBSOLETE. http://purl.obolibrary.org/obo/MP_0000374 obsolete pink fur hue OBSOLETE. hairs have a prominent pink tinge http://purl.obolibrary.org/obo/MP_0000386 obsolete abnormal hair follicle root sheath OBSOLETE. anomalies of the epidermal-derived layer surrounding the hair follicle; innermost of two layers http://purl.obolibrary.org/obo/MP_0000395 obsolete abnormal hair types OBSOLETE. any structural anomaly of the different subsets of types of hairs or change to the expected complement of different hair types http://purl.obolibrary.org/obo/MP_0000419 obsolete rough hair OBSOLETE. greasy, matted appearance of the fur http://purl.obolibrary.org/obo/MP_0000476 obsolete thickening of bowel wall OBSOLETE. http://purl.obolibrary.org/obo/MP_0000483 obsolete Increased intestinal cell number OBSOLETE. http://purl.obolibrary.org/obo/MP_0000485 obsolete Decreased intestinal cell number OBSOLETE. http://purl.obolibrary.org/obo/MP_0000502 obsolete abnormal digestive mucosecretion OBSOLETE. malfunctioning of the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from the mucous membrane of the digestive system http://purl.obolibrary.org/obo/MP_0000504 obsolete excessive digestive mucosecretion increase in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from the mucous membrane of the digestive system http://purl.obolibrary.org/obo/MP_0000506 obsolete decreased digestive mucosecretion reduction in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from the mucous membrane of the digestive system http://purl.obolibrary.org/obo/MP_0000509 obsolete absent digestive mucosecretion failure to produce and/or release a physiologically active substance (usually but not exclusively in liquid form) from the mucous membrane of the digestive system http://purl.obolibrary.org/obo/MP_0000513 obsolete infiltration of lymphocytes/plasma cells OBSOLETE. http://purl.obolibrary.org/obo/MP_0000541 obsolete abnormal urinary bladder transitional epithelium morphology any structural anomaly of the transitional epithelial layer of the urinary bladder http://purl.obolibrary.org/obo/MP_0000545 obsolete abnormal limbs/digits/tail morphology OBSOLETE. morphological or developmental anomaly of the digits, autopod, limbs, or tail http://purl.obolibrary.org/obo/MP_0000581 obsolete ventral nails/ hair OBSOLETE. appearance of nails and hair on the ventral side of the paw http://purl.obolibrary.org/obo/MP_0000593 obsolete tail band OBSOLETE. http://purl.obolibrary.org/obo/MP_0000612 obsolete sclerosis OBSOLETE. http://purl.obolibrary.org/obo/MP_0000637 obsolete abnormal merkel cells OBSOLETE. http://purl.obolibrary.org/obo/MP_0000638 obsolete hyperproliferation of merkel cells OBSOLETE. http://purl.obolibrary.org/obo/MP_0000672 obsolete decreased mucin cell number OBSOLETE. fewer than normal number of cells that secrete fluid containing carbohydrate-rich glycoproteins http://purl.obolibrary.org/obo/MP_0000697 obsolete more prevalent Peyer's patches OBSOLETE. greater or more obvious numbers of Peyer's patches http://purl.obolibrary.org/obo/MP_0000698 obsolete less prevalent Peyer's patches OBSOLETE. fewer or less obvious numbers of Peyer's patches http://purl.obolibrary.org/obo/MP_0000712 obsolete abnormal thymocyte OBSOLETE. http://purl.obolibrary.org/obo/MP_0000713 obsolete abnormal thymocyte number OBSOLETE. http://purl.obolibrary.org/obo/MP_0000768 obsolete nervous system abnormalities OBSOLETE. any malformation or anomaly in the entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses http://purl.obolibrary.org/obo/MP_0000779 obsolete gliosis of tract OBSOLETE. http://purl.obolibrary.org/obo/MP_0000816 obsolete abnormal hippocampal molecular layer morphology OBSOLETE. http://purl.obolibrary.org/obo/MP_0000838 obsolete abnormal pituitary afferents OBSOLETE. http://purl.obolibrary.org/obo/MP_0000881 obsolete Abnormal Purkinje Cell Size OBSOLETE. http://purl.obolibrary.org/obo/MP_0000882 obsolete Increased Purkinje Cell Size OBSOLETE. http://purl.obolibrary.org/obo/MP_0000883 obsolete Decreased Purkinje Cell Size OBSOLETE. http://purl.obolibrary.org/obo/MP_0000891 obsolete Abnormal Thickness of Molecular Layer OBSOLETE. http://purl.obolibrary.org/obo/MP_0000892 obsolete Increased Thickness of Molecular Layer OBSOLETE. http://purl.obolibrary.org/obo/MP_0000893 obsolete Decreased Thickness of Molecular Layer OBSOLETE. http://purl.obolibrary.org/obo/MP_0000894 obsolete Abnormal Cell Number of Molecular Layer OBSOLETE. http://purl.obolibrary.org/obo/MP_0000895 obsolete Increased Cell Number of Molecular Layer OBSOLETE. http://purl.obolibrary.org/obo/MP_0000896 obsolete Decreased Cell Number of Molecular Layer OBSOLETE. http://purl.obolibrary.org/obo/MP_0000941 obsolete failure of motor neuron target finding OBSOLETE. failure of an innervating motor neuron to stop at target site and form terminal arbors http://purl.obolibrary.org/obo/MP_0000942 obsolete excessive motor neuron axon growth OBSOLETE. innervating motor neuron projections grow past typical endplate target and extend to myotendenous ends of muscle http://purl.obolibrary.org/obo/MP_0000944 obsolete Reduced Olfactory mitral Cells OBSOLETE. http://purl.obolibrary.org/obo/MP_0001018 obsolete abnormal adrenal gland ganglion OBSOLETE. http://purl.obolibrary.org/obo/MP_0001027 obsolete abnormal adrenergic innervation OBSOLETE. http://purl.obolibrary.org/obo/MP_0001028 obsolete adrenergic hyperinnervation of muscle OBSOLETE. http://purl.obolibrary.org/obo/MP_0001031 obsolete cholinergic hyperinnervation of muscle OBSOLETE. http://purl.obolibrary.org/obo/MP_0001039 obsolete abnormal cholinergic innervation OBSOLETE. malformation or absence of the supply of nerve fibers that utilize acetylcholine as a neurotransmitter http://purl.obolibrary.org/obo/MP_0001041 obsolete absent lacrimal gland cholinergic innervation OBSOLETE. missing supply of nerve fibers to the gland that secretes tears http://purl.obolibrary.org/obo/MP_0001042 obsolete absent sublingual salivary gland cholinergic innervation OBSOLETE. missing supply of nerve fibers to the exocrine gland on the floor of the mouth that secretes saliva http://purl.obolibrary.org/obo/MP_0001043 obsolete absent parotid salivary gland cholinergic innervation OBSOLETE. missing supply of nerve fibers to the exocrine gland lateral to the jaw that secretes saliva http://purl.obolibrary.org/obo/MP_0001091 obsolete small vestibular cochlear ganglion OBSOLETE. http://purl.obolibrary.org/obo/MP_0001173 obsolete decreased number of ductal cells of the bulbourethral gland OBSOLETE. fewer than the normal number of cells found in the ducts through which the bulbourethral glands discharge mucus into the spongy part of the urethra http://purl.obolibrary.org/obo/MP_0001180 obsolete cellular infiltration of airway walls OBSOLETE. http://purl.obolibrary.org/obo/MP_0001248 obsolete absent connective tissue OBSOLETE. missing supporting framework of a tissue or the body; formed of fibrous or ground substance http://purl.obolibrary.org/obo/MP_0001249 obsolete absent dermal adipose tissue OBSOLETE. missing fat associated with the skin layers http://purl.obolibrary.org/obo/MP_0001301 obsolete abnormal eye movement OBSOLETE. http://purl.obolibrary.org/obo/MP_0001323 obsolete iris opacity OBSOLETE. milky or cloudy iris that is impervious to light http://purl.obolibrary.org/obo/MP_0001335 obsolete Subject to Infection OBSOLETE. http://purl.obolibrary.org/obo/MP_0001336 obsolete increased incidence of inflamed eyes OBSOLETE. greater than normal frequency of inflammatory response in the eyes http://purl.obolibrary.org/obo/MP_0001359 obsolete piling OBSOLETE. http://purl.obolibrary.org/obo/MP_0001365 obsolete increased escape behavior induced by intruder mouse OBSOLETE. resident animals exhibit escape behavior and do not initiate social investigation of an intruder mouse http://purl.obolibrary.org/obo/MP_0001366 obsolete impaired stress response in porsolt forced swin test OBSOLETE. reduced freezing behavior resulting from failed escape attempts induced by forced swim in a small cylinder http://purl.obolibrary.org/obo/MP_0001373 obsolete Increased Fecundity OBSOLETE. http://purl.obolibrary.org/obo/MP_0001387 obsolete abnormal movement/ locomotion OBSOLETE. http://purl.obolibrary.org/obo/MP_0001398 obsolete backflips OBSOLETE. http://purl.obolibrary.org/obo/MP_0001414 obsolete Increased Response to New Environment OBSOLETE. http://purl.obolibrary.org/obo/MP_0001416 obsolete Decreased Response to New Environment OBSOLETE. http://purl.obolibrary.org/obo/MP_0001418 obsolete open field locomotion abnormalities OBSOLETE. http://purl.obolibrary.org/obo/MP_0001421 obsolete touch escape OBSOLETE. http://purl.obolibrary.org/obo/MP_0001424 obsolete abnormal water consumption OBSOLETE. drinking water in anomalous quantities http://purl.obolibrary.org/obo/MP_0001444 obsolete compulsive biting OBSOLETE. http://purl.obolibrary.org/obo/MP_0001445 obsolete compulsive licking OBSOLETE. http://purl.obolibrary.org/obo/MP_0001450 obsolete Altered Intelligence OBSOLETE. http://purl.obolibrary.org/obo/MP_0001451 obsolete Decreased Intelligence OBSOLETE. http://purl.obolibrary.org/obo/MP_0001452 obsolete Increased Intelligence OBSOLETE. http://purl.obolibrary.org/obo/MP_0001455 obsolete normal cued fear conditioning OBSOLETE. http://purl.obolibrary.org/obo/MP_0001456 obsolete impaired long term memory in cued fear conditioning test OBSOLETE. altered ability to recall an association between an auditory cue and a foot shock over time; measured by "freezing" of animal in response to auditory cue http://purl.obolibrary.org/obo/MP_0001457 obsolete impaired long term memory in contextual fear test OBSOLETE. altered ability to recall an association between a location and a foot shock over time; measured by "freezing" of animal in response to auditory cue http://purl.obolibrary.org/obo/MP_0001459 obsolete impaired memory in novel object recognition test OBSOLETE. reduced time spent exploring a novel object that replaced a training object after a specified retention time http://purl.obolibrary.org/obo/MP_0001461 obsolete impaired memory in olfactory discrimination test OBSOLETE. reduced food preference based on food recently smelled on the breath of other individuals http://purl.obolibrary.org/obo/MP_0001464 obsolete impaired learning in eight arm radial maze test OBSOLETE. reduced ability to remember a sequence of previously visited feeding sites in an eight arm maze http://purl.obolibrary.org/obo/MP_0001465 obsolete morris water maze OBSOLETE. http://purl.obolibrary.org/obo/MP_0001470 obsolete impaired long term memory in step-down avoidance test OBSOLETE. http://purl.obolibrary.org/obo/MP_0001471 obsolete large place fields OBSOLETE. http://purl.obolibrary.org/obo/MP_0001482 obsolete Increased Pupil Restriction OBSOLETE. http://purl.obolibrary.org/obo/MP_0001483 obsolete Decreased Pupil Restriction OBSOLETE. http://purl.obolibrary.org/obo/MP_0001503 obsolete abnormal strength/ posture OBSOLETE. http://purl.obolibrary.org/obo/MP_0001507 obsolete positional passivity OBSOLETE. http://purl.obolibrary.org/obo/MP_0001508 obsolete abnormal body tone OBSOLETE. http://purl.obolibrary.org/obo/MP_0001509 obsolete abnormal body position OBSOLETE. http://purl.obolibrary.org/obo/MP_0001514 obsolete abnormal footprint pathway OBSOLETE. http://purl.obolibrary.org/obo/MP_0001530 obsolete Increased Vocalization OBSOLETE. http://purl.obolibrary.org/obo/MP_0001531 obsolete Decreased Vocalization OBSOLETE. http://purl.obolibrary.org/obo/MP_0001532 obsolete Physiology OBSOLETE. http://purl.obolibrary.org/obo/MP_0001584 obsolete platelet storage pool deficiency OBSOLETE. a blood coagulation disorder in which there is a decrease or lack of platelet dense bodies http://purl.obolibrary.org/obo/MP_0001615 obsolete Decreased Vasculature OBSOLETE. http://purl.obolibrary.org/obo/MP_0001616 obsolete Increased Vasculature OBSOLETE. http://purl.obolibrary.org/obo/MP_0001637 obsolete cardiac arrest OBSOLETE. complete cessation of cardiac activity http://purl.obolibrary.org/obo/MP_0001641 obsolete death OBSOLETE. cessation of life; cessation of integrated tissue and organ functions; a gradual process at the cellular level http://purl.obolibrary.org/obo/MP_0001651 obsolete necrosis pathological death of cells or a portion of a tissue or organ; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0001659 obsolete altered life span OBSOLETE. http://purl.obolibrary.org/obo/MP_0001720 obsolete excessive surface folding OBSOLETE. http://purl.obolibrary.org/obo/MP_0001734 obsolete abnormal endocrine organ OBSOLETE. any structural anomaly of any of the glands that have no ducts, their secretions being absorbed directly into the blood http://purl.obolibrary.org/obo/MP_0001741 obsolete decreased adrenaline synthesis OBSOLETE. less than the normal formation of this catecholamine hormone that stimulates the adrenergic receptors http://purl.obolibrary.org/obo/MP_0001755 obsolete abnormal excretion physiology OBSOLETE. http://purl.obolibrary.org/obo/MP_0001763 obsolete Infrequent Urination OBSOLETE. http://purl.obolibrary.org/obo/MP_0001766 obsolete abnormal aluminum level OBSOLETE. http://purl.obolibrary.org/obo/MP_0001791 obsolete immunodeficiency OBSOLETE. defective immune response; can be primary due to defect in immune system or secondary due to disease http://purl.obolibrary.org/obo/MP_0001794 obsolete Bacterial OBSOLETE. http://purl.obolibrary.org/obo/MP_0001795 obsolete Gram Negative OBSOLETE. http://purl.obolibrary.org/obo/MP_0001796 obsolete Gram Positive OBSOLETE. http://purl.obolibrary.org/obo/MP_0001797 obsolete Opportunistic Infections of the Intestinal Tract OBSOLETE. http://purl.obolibrary.org/obo/MP_0001799 obsolete Viral OBSOLETE. http://purl.obolibrary.org/obo/MP_0001804 obsolete abnormal complement protein physiology OBSOLETE. functional anomaly of any of the complement proteins http://purl.obolibrary.org/obo/MP_0001808 obsolete B cell Immunodeficiency OBSOLETE. http://purl.obolibrary.org/obo/MP_0001809 obsolete Abnormal Immunoglobulin Production OBSOLETE. http://purl.obolibrary.org/obo/MP_0001817 obsolete abnormal antibody production OBSOLETE. http://purl.obolibrary.org/obo/MP_0001818 obsolete abnormal antibody titer OBSOLETE. http://purl.obolibrary.org/obo/MP_0001820 obsolete abnormal activated B cell number OBSOLETE. http://purl.obolibrary.org/obo/MP_0001831 obsolete T cell immunodeficiency OBSOLETE.defective immune response due to defective T-lymphocyte response http://purl.obolibrary.org/obo/MP_0001832 obsolete CD4-Positive cell immunodeficiency OBSOLETE. http://purl.obolibrary.org/obo/MP_0001833 obsolete CD8- Positive cell immunodeficiency OBSOLETE. http://purl.obolibrary.org/obo/MP_0001834 obsolete macrophage immunodeficiency/impairment OBSOLETE. http://purl.obolibrary.org/obo/MP_0001842 obsolete inability to present cytosolic antigens to Class-I restricted cytotoxic T cells OBSOLETE. http://purl.obolibrary.org/obo/MP_0001877 obsolete dysregulated inflammatory response OBSOLETE. http://purl.obolibrary.org/obo/MP_0001886 obsolete nervous system physiology abnormalities OBSOLETE. http://purl.obolibrary.org/obo/MP_0001895 obsolete abnormal hippocampus function OBSOLETE. any anomaly in the activity of the deep lying structure of the cerebrum involved with memory storage http://purl.obolibrary.org/obo/MP_0001903 obsolete reduced NMDA receptor glycine affinity: hippocampus OBSOLETE. http://purl.obolibrary.org/obo/MP_0001904 obsolete impaired GABA receptor mediated fast inhibition OBSOLETE. http://purl.obolibrary.org/obo/MP_0001907 obsolete abnormal cerebellar function OBSOLETE. any anomaly in the activity of the portion of the brain in the back of the head between the cerebrum and the pons that controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills http://purl.obolibrary.org/obo/MP_0001949 obsolete abnormal respiratory dead space OBSOLETE. anomaly in the section of the respiratory tract that does not exchange oxygen and carbon dioxide with pulmonary capillary blood http://purl.obolibrary.org/obo/MP_0001959 obsolete sensory system physiology/response abnormalities OBSOLETE. http://purl.obolibrary.org/obo/MP_0001964 obsolete abnormal auditory threshold OBSOLETE. change in the average point at which one may first detect electrical activity generated by neurons in the ascending auditory system by using computer-averaged responses to short tone bursts at varying frequency http://purl.obolibrary.org/obo/MP_0001965 obsolete increased auditory threshold OBSOLETE. a greater than average point at which one may first detect electrical activity generated by neurons in the ascending auditory system by using computer-averaged responses to short tone bursts at varying frequency http://purl.obolibrary.org/obo/MP_0001966 obsolete decreased auditory threshold OBSOLETE. a lower than average point at which one may first detect electrical activity generated by neurons in the ascending auditory system by using computer-averaged responses to short tone bursts at varying frequency http://purl.obolibrary.org/obo/MP_0001974 obsolete toe pinch OBSOLETE. http://purl.obolibrary.org/obo/MP_0001975 obsolete tail pinch OBSOLETE. http://purl.obolibrary.org/obo/MP_0001977 obsolete tail flick OBSOLETE. http://purl.obolibrary.org/obo/MP_0001978 obsolete prolonged latency in tail flick test OBSOLETE. http://purl.obolibrary.org/obo/MP_0001989 obsolete saccharin versus water OBSOLETE. http://purl.obolibrary.org/obo/MP_0001990 obsolete water versus saccharin OBSOLETE. http://purl.obolibrary.org/obo/MP_0001997 obsolete Increased Pupil Constriction OBSOLETE. http://purl.obolibrary.org/obo/MP_0001998 obsolete Decreased Pupil Constriction OBSOLETE. http://purl.obolibrary.org/obo/MP_0002002 obsolete abnormal response to visual cliff OBSOLETE. http://purl.obolibrary.org/obo/MP_0002010 obsolete hepatic microgranulomas OBSOLETE. http://purl.obolibrary.org/obo/MP_0002025 obsolete B cell/T cell derived lymphoma OBSOLETE. group of heterogeneous lymphoid tumors representing malignant transformations of both B-lymphocytes and T-lymphocytes http://purl.obolibrary.org/obo/MP_0002042 obsolete hemotologic neoplasia OBSOLETE. http://purl.obolibrary.org/obo/MP_0002054 obsolete disease states OBSOLETE. http://purl.obolibrary.org/obo/MP_0002055 obsolete Diabetes OBSOLETE. either insipidus or mellitus. Having in common the symptoms of polyuria http://purl.obolibrary.org/obo/MP_0002056 obsolete Insulin dependent diabetes Obsolete. Characterized by polydipsia, polyuria, increased appetite, weight loss, low plasma insulin levels, and episodic ketoacidosis http://purl.obolibrary.org/obo/MP_0002057 obsolete Non-insulin dependent diabetes OBSOLETE. Type II, adult onset. mild form gradual onset, usually in obese individuals. Plasma insulin levels are normal to high , but low in relation to plasma glucose levels. Responsive to dietary regulation or oral hypoglycemic agents, but diabetic complications and degenerative changes can develop http://purl.obolibrary.org/obo/MP_0002070 obsolete abnormal sleep pattern/circadian rhythm OBSOLETE. deviation from the normal 24 hour biological activity cycle including the wake/sleep cycle http://purl.obolibrary.org/obo/MP_0002071 obsolete other abnormal behavior OBSOLETE. abnormal behaviors not attributable to other categories http://purl.obolibrary.org/obo/MP_0002072 obsolete neurological/behavioral: no defect detected OBSOLETE. no anomaly observed in neurological or behavioral tests http://purl.obolibrary.org/obo/MP_0002076 obsolete abnormal hair follicle structure/orientation OBSOLETE. any structural anomaly or misalignment of the epidermis from which the hair shaft develops http://purl.obolibrary.org/obo/MP_0002087 obsolete embryogenesis: no defect detected OBSOLETE. no anomaly observed in examination of embryonic development http://purl.obolibrary.org/obo/MP_0002091 obsolete eye: no defect detected OBSOLETE. no anomaly observed in examination of eye tissue http://purl.obolibrary.org/obo/MP_0002093 obsolete abnormal cornea/lens morphology OBSOLETE. any dysmorphology or complete or partial opacity of the lens or cornea http://purl.obolibrary.org/obo/MP_0002094 obsolete coat: no defect detected OBSOLETE. no anomaly observed in examination of coat http://purl.obolibrary.org/obo/MP_0002096 obsolete abnormal skin condition/ morphology OBSOLETE. any structural anomaly or atypical condition of the skin http://purl.obolibrary.org/obo/MP_0002097 obsolete skin: no defect detected OBSOLETE. no anomaly observed in examination of skin http://purl.obolibrary.org/obo/MP_0002099 obsolete vibrissae: no defect detected OBSOLETE. no anomaly observed in examination of whiskers http://purl.obolibrary.org/obo/MP_0002101 obsolete teeth: no defect detected OBSOLETE. no anomaly observed in examination of teeth http://purl.obolibrary.org/obo/MP_0002103 obsolete ears: no defect detected OBSOLETE. no anomaly observed in examination of auditory tissue or in hearing assessment http://purl.obolibrary.org/obo/MP_0002107 obsolete musculature: no defect detected OBSOLETE. no anomaly observed in examination of muscle tissue or in physiological assessment http://purl.obolibrary.org/obo/MP_0002112 obsolete extremities: no defect detected OBSOLETE. no anomaly observed in examination of extremities http://purl.obolibrary.org/obo/MP_0002117 obsolete skeletal: no defect detected OBSOLETE. no anomaly observed in examination of bones and/or skeleton http://purl.obolibrary.org/obo/MP_0002121 obsolete other metabolic defect OBSOLETE. altered chemical and physical processes of the body or of a tissue, not due to lipid or glucose chemistry http://purl.obolibrary.org/obo/MP_0002122 obsolete metabolism: no defect detected OBSOLETE. no anomaly observed in examination of metabolic function http://purl.obolibrary.org/obo/MP_0002126 obsolete hematology: no defect detected OBSOLETE. no anomaly observed in examination of hematological development or function http://purl.obolibrary.org/obo/MP_0002131 obsolete heart/cardiovascular system: no defect detected OBSOLETE. no anomaly observed in examination of heart or vascular tissue or in cardiovascular function http://purl.obolibrary.org/obo/MP_0002134 obsolete respiratory system: no defect detected OBSOLETE. no anomaly observed in examination of lung and other respiratory tissues http://purl.obolibrary.org/obo/MP_0002137 obsolete kidney/renal system: no defect detected OBSOLETE. no anomaly observed in examination of kidney and other renal tissues http://purl.obolibrary.org/obo/MP_0002140 obsolete liver/hepatic system: no defect detected OBSOLETE. no anomaly observed in examination of liver or other hepatic tissues http://purl.obolibrary.org/obo/MP_0002143 obsolete digestive system: no defect detected OBSOLETE. no anomaly obsesrved in the function of or in any region of the digestive system http://purl.obolibrary.org/obo/MP_0002146 obsolete immune system: other dysmorphology OBSOLETE. abnormal development of lymphocytes or lymphatic tissue (other than B or T lymphocytes) resulting in morphological abnormality http://purl.obolibrary.org/obo/MP_0002147 obsolete immune system: immunodeficiency OBSOLETE. defective immune response; can be primary due to defect in immune system or secondary due to disease http://purl.obolibrary.org/obo/MP_0002149 obsolete immune system: other functional anomaly OBSOLETE. altered immune response not due to anatomical defect, immunodeficiency or hypersensitivity http://purl.obolibrary.org/obo/MP_0002150 obsolete immune system: no defect detected OBSOLETE. no anomaly observed in examination of immune system tissues or function http://purl.obolibrary.org/obo/MP_0002156 obsolete central nervous system: no defect detected OBSOLETE. no anomaly observed in examination of central nervous system tissues or function http://purl.obolibrary.org/obo/MP_0002159 obsolete peripheral nervous system: no defect detected OBSOLETE. no anomaly observed in examination of peripheral nervous system tissues or function http://purl.obolibrary.org/obo/MP_0002162 obsolete reproductive system: no defect detected OBSOLETE. no anomaly observed in examination of reproductive system tissues or function http://purl.obolibrary.org/obo/MP_0002165 obsolete glands: no defect detected OBSOLETE. no anomaly observed in examination of endocrine system tissues or function http://purl.obolibrary.org/obo/MP_0002167 obsolete unaffected tumor susceptibility/resistance OBSOLETE. average number of tumors in an organism compared to controls, usually referring to a specific tumor type http://purl.obolibrary.org/obo/MP_0002180 obsolete OBSOLETE. http://purl.obolibrary.org/obo/MP_0002181 obsolete abnormal brain cell morphology OBSOLETE. any structural anomaly of any or all brain cell types http://purl.obolibrary.org/obo/MP_0002185 obsolete ectopia OBSOLETE. congenital positional anomaly or displacement of any part of the body or organ http://purl.obolibrary.org/obo/MP_0002201 obsolete abnormal neurotransmitter receptor physiology OBSOLETE. aberrant function of cell surface receptors that bind signaling molecules released by neurons and convert these signals into intracellular changes influencing the behavior of cells http://purl.obolibrary.org/obo/MP_0002205 obsolete neurotransmitter imbalance OBSOLETE. http://purl.obolibrary.org/obo/MP_0002215 obsolete testicular feminization OBSOLETE. an XY animal displaying female sex characteristics, usually due to an X-linked mutation http://purl.obolibrary.org/obo/MP_0002222 obsolete abnormal lymph organ cellularity OBSOLETE. change in the normal number of cells within a lymph organ http://purl.obolibrary.org/obo/MP_0002225 obsolete abnormal spleen cellularity OBSOLETE. anomaly in the cellular makeup of the spleen http://purl.obolibrary.org/obo/MP_0002232 obsolete sensory capabilities OBSOLETE. http://purl.obolibrary.org/obo/MP_0002278 obsolete abnormal respiratory muscle morphology OBSOLETE. structural anomaly of any of the muscles involved in breathing http://purl.obolibrary.org/obo/MP_0002283 obsolete hyaline cartilage abnormalities OBSOLETE. http://purl.obolibrary.org/obo/MP_0002287 obsolete reproductive system: fertility/fecundity characteristics OBSOLETE. http://purl.obolibrary.org/obo/MP_0002288 obsolete litter size OBSOLETE. http://purl.obolibrary.org/obo/MP_0002291 obsolete fecundity characteristics OBSOLETE. http://purl.obolibrary.org/obo/MP_0002298 obsolete abnormal maximal expiratory flow rate OBSOLETE. http://purl.obolibrary.org/obo/MP_0002299 obsolete abnormal maximal expiratory flow-volume curve OBSOLETE. http://purl.obolibrary.org/obo/MP_0002300 obsolete abnormal maximal midexpiratory flow rate OBSOLETE. http://purl.obolibrary.org/obo/MP_0002301 obsolete abnormal peak expiratory flow rate OBSOLETE. http://purl.obolibrary.org/obo/MP_0002302 obsolete abnormal forced expiratory volume OBSOLETE. anomaly in the maximum amount of air that can be expelled in a given number of seconds during a forced vital capacity determination http://purl.obolibrary.org/obo/MP_0002303 obsolete abnormal maximal voluntary ventilation OBSOLETE. anomaly in the maximum amount of air that can be breathed in and blown out over a specified interval http://purl.obolibrary.org/obo/MP_0002305 obsolete abnormal closing volume OBSOLETE. http://purl.obolibrary.org/obo/MP_0002307 obsolete abnormal expiratory reserve volume OBSOLETE. anomaly in the amount of the extra volume of air that can be expired with maximum effort beyond the level reached at the end of a normal expiration http://purl.obolibrary.org/obo/MP_0002315 obsolete abnormal respiratory signs/symptoms OBSOLETE. manifestations of diseases of the respiratory tract http://purl.obolibrary.org/obo/MP_0002341 obsolete abnormal lymph node capsule OBSOLETE. anomaly in the connective tissue that surrounds a lymph node http://purl.obolibrary.org/obo/MP_0002355 obsolete abnormal spleen venous sinus OBSOLETE. http://purl.obolibrary.org/obo/MP_0002365 obsolete abnormal thymus cellularity OBSOLETE. anomaly in the cellular makeup of the thymus http://purl.obolibrary.org/obo/MP_0002373 obsolete abnormal macrophages in the thymus OBSOLETE. http://purl.obolibrary.org/obo/MP_0002374 obsolete abnormal thymus epithelial cells OBSOLETE. http://purl.obolibrary.org/obo/MP_0002381 obsolete abnormal tonsil capsule OBSOLETE. http://purl.obolibrary.org/obo/MP_0002382 obsolete abnormal lymphatic nodules with germinal centers OBSOLETE. http://purl.obolibrary.org/obo/MP_0002383 obsolete abnormal tonsil crypts OBSOLETE. http://purl.obolibrary.org/obo/MP_0002387 obsolete abnormal prevalence of Peyer's patches OBSOLETE. deviation from the normal distribution and/or number of Peyer's patches http://purl.obolibrary.org/obo/MP_0002390 obsolete abnormal Peyer's patch dome OBSOLETE. http://purl.obolibrary.org/obo/MP_0002394 obsolete absent thymocyte subset OBSOLETE. lack of a particular group of T cells http://purl.obolibrary.org/obo/MP_0002395 obsolete hemolymphoid system abnormalities OBSOLETE. anomalies of the blood and blood-forming tissues or of the immune system and immune cell forming tissues http://purl.obolibrary.org/obo/MP_0002426 obsolete blood abnormalities OBSOLETE. structural anomalies in the cells, fluids, or proteins found in the blood http://purl.obolibrary.org/obo/MP_0002468 obsolete abnormal complement physiology OBSOLETE. abnormal function of the set of plasma proteins that act together to attack extracellular pathogens http://purl.obolibrary.org/obo/MP_0002469 obsolete abnormal C1 physiology OBSOLETE. abnormal function of the complement protein, C1 http://purl.obolibrary.org/obo/MP_0002470 obsolete abnormal C2 physiology OBSOLETE. abnormal function of the complement protein, C2 http://purl.obolibrary.org/obo/MP_0002474 obsolete abnormal C3 physiology OBSOLETE. abnormal function of the complement protein, C3 http://purl.obolibrary.org/obo/MP_0002475 obsolete abnormal C4 physiology OBSOLETE. abnormal function of the complement protein, C4 http://purl.obolibrary.org/obo/MP_0002476 obsolete abnormal C5 physiology OBSOLETE. abnormal function of the complement protein, C5 http://purl.obolibrary.org/obo/MP_0002477 obsolete abnormal C6 physiology OBSOLETE. abnormal function of the complement protein, C6 http://purl.obolibrary.org/obo/MP_0002478 obsolete abnormal C7 physiology OBSOLETE. abnormal function of the complement protein, C7 http://purl.obolibrary.org/obo/MP_0002479 obsolete abnormal C8 physiology OBSOLETE. abnormal function of the complement protein, C8 http://purl.obolibrary.org/obo/MP_0002480 obsolete abnormal C9 physiology OBSOLETE. abnormal function of the complement protein, C9 http://purl.obolibrary.org/obo/MP_0002481 obsolete abnormal factor B physiology OBSOLETE. abnormal function of the complement protein, factor B http://purl.obolibrary.org/obo/MP_0002482 obsolete abnormal factor D physiology OBSOLETE. abnormal function of the complement protein, factor D http://purl.obolibrary.org/obo/MP_0002483 obsolete abnormal acute phase protein physiology OBSOLETE. functional anomaly in the series of proteins found in the blood shortly after infection and which participate in the early phases of host defense against infection http://purl.obolibrary.org/obo/MP_0002484 obsolete abnormal C-reactive protein physiology OBSOLETE. anomaly in the function of this plasma protein that normally circulates in increased amounts during inflammation or after tissue damage http://purl.obolibrary.org/obo/MP_0002485 obsolete abnormal mannose-binding protein physiology OBSOLETE. an anomaly in the function of this acute phase protein that normally opsonizes pathogens bearing mannose on their surfaces and can activate the complement system http://purl.obolibrary.org/obo/MP_0002486 obsolete abnormal serum amyloid protein physiology OBSOLETE. any functional anomaly in an acute-phase reaction protein that is a precursor to amyloid A protein; it is present in very high levels during acute inflammatory episodes, and is present in low concentrations in normal sera, but is found at higher concentrations in sera of older persons and in patients with amyloidosis http://purl.obolibrary.org/obo/MP_0002487 obsolete abnormal fibrinogen physiology OBSOLETE. an anomaly in the function of this coaguable protein in the blood plasma http://purl.obolibrary.org/obo/MP_0002488 obsolete abnormal phagocyte physiology OBSOLETE. anomaly in the ability of these cells to ingest and internalize particulate matter http://purl.obolibrary.org/obo/MP_0002501 obsolete abnormal inflammatory mediator physiology OBSOLETE. functional anomaly of any of the endogenous compounds that mediate the local accumulation of fluid, plasma proteins, and leukocytes at the site of injury, insult, or infection http://purl.obolibrary.org/obo/MP_0002502 obsolete abnormal vasoactive mediator physiology OBSOLETE. functional anomaly of any of the endogenous compounds that act on the vasculature http://purl.obolibrary.org/obo/MP_0002504 obsolete abnormal serotonin physiology OBSOLETE. functional anomaly of this biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets; it normally mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity http://purl.obolibrary.org/obo/MP_0002505 obsolete abnormal bradykinin physiology OBSOLETE. functional anomaly of this potent, short-lived vasoactive peptide that causes arteriolar dilation and increased capillary permeability http://purl.obolibrary.org/obo/MP_0002506 obsolete abnormal anaphylotoxin physiology OBSOLETE. functional anomaly of any of the small fragments of complement proteins released by cleavage during complement activation, they are chemotactic and vasoactive http://purl.obolibrary.org/obo/MP_0002507 obsolete abnormal C4a physiology OBSOLETE. functional anomaly of complement fragment C4a, which is normally involved in increasing vascular permeability and enhancing smooth muscle contraction http://purl.obolibrary.org/obo/MP_0002508 obsolete abnormal complement 5a physiology OBSOLETE. functional anomaly of this product of complement activation that is a potent chemotactic factor for neutrophils, monocytes, and basophils and enhances smooth muscle contraction and vascular permeability http://purl.obolibrary.org/obo/MP_0002509 obsolete abnormal C3a physiology OBSOLETE. functional anomaly of complement fragment C3a, which is normally involved in increasing vascular permeability and enhancing smooth muscle contraction http://purl.obolibrary.org/obo/MP_0002510 obsolete abnormal leukotriene physiology OBSOLETE. functional anomaly of any of a family of mediators derived from arachidonic acid which normally stimulate smooth muscle contraction, increase vascular permeability, and may be chemoattractants for inflammatory cells http://purl.obolibrary.org/obo/MP_0002511 obsolete abnormal leukotriene C4 physiology OBSOLETE. any functional anomaly of the conjugation product of leukotriene a4 and glutathione; it is the major arachidonic acid metabolite in macrophages and mast cells as well as in antigen-sensitized lung tissue, and it normally stimulates mucus secretion in the lung, and produces contractions of nonvascular and some vascular smooth muscle http://purl.obolibrary.org/obo/MP_0002512 obsolete abnormal leukotriene D4 physiology OBSOLETE. any functional anomaly of a leukotriene c4 derivative generated after partial hydrolysis of the gamma-glutamyl portion of the peptide chain; its biological actions normally include stimulation of vascular and nonvascular smooth muscle, and increases in vascular permeability http://purl.obolibrary.org/obo/MP_0002513 obsolete abnormal leukotriene E4 physiology OBSOLETE. any functional anomaly of a leukotriene d4 derivative generated by a peptidase reaction that removes the glycine residue; its biological actions normally include stimulation of vascular and nonvascular smooth muscle, and increases in vascular permeability http://purl.obolibrary.org/obo/MP_0002514 obsolete abnormal prostaglandin physiology OBSOLETE. functional anomaly of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation http://purl.obolibrary.org/obo/MP_0002515 obsolete PGD2 OBSOLETE. http://purl.obolibrary.org/obo/MP_0002516 obsolete abnormal PGE2 physiology OBSOLETE. functional anomaly of this member of the prostaglandin family, which normally has vasodilatory effects, increasing vascular permeability http://purl.obolibrary.org/obo/MP_0002517 obsolete abnormal PGI2 physiology OBSOLETE. functional anomaly of this member of the prostaglandin family that normally has vasodilatory effects, increasing vascular permeability http://purl.obolibrary.org/obo/MP_0002518 obsolete abnormal PGF2alpha physiology OBSOLETE. functional anomaly of this prostaglandin that normally has vasocontractile, oxytocic, luteolytic, and abortifacient activities http://purl.obolibrary.org/obo/MP_0002519 obsolete abnormal thromboxane physiology OBSOLETE. functional anomaly of any of the members of a family of mediators with vasoactive effects http://purl.obolibrary.org/obo/MP_0002520 obsolete abnormal TxA2 physiology OBSOLETE. functional anomaly of this potent vasoconstrictor that also mediates platelet aggregation http://purl.obolibrary.org/obo/MP_0002521 obsolete abnormal platelet activating factor physiology OBSOLETE. functional anomaly of this mediator generated by nearly all activated inflammatory cells, endothelial cells, and injured tissue cells; normally it is a potent vasodilator and enhances microvasculature permeability, in addition, it induces platelet aggregation and degranulation at sites of injury and enhances the release of serotonin http://purl.obolibrary.org/obo/MP_0002522 obsolete abnormal chemotactic factor physiology OBSOLETE. functional anomaly of any of a class of pro-inflammatory proteins that attract and activate leukocytes http://purl.obolibrary.org/obo/MP_0002523 obsolete abnormal chemotactic complement factor physiology OBSOLETE. functional anomaly of any of a subset of complement fragments that are involved in recruitment of leukocytes to the site of injury http://purl.obolibrary.org/obo/MP_0002524 obsolete lipoxygenase products OBSOLETE. http://purl.obolibrary.org/obo/MP_0002525 obsolete abnormal leukotriene B4 physiology OBSOLETE. functional anomaly of this product of inflammatory cell activation that is a potent chemoattractant for macrophages and neutrophils http://purl.obolibrary.org/obo/MP_0002526 obsolete abnormal chemokine physiology OBSOLETE. functional anomaly of any of the class of pro-inflammatory cytokines that attract and activate leukocytes http://purl.obolibrary.org/obo/MP_0002527 obsolete abnormal interleukin-8 physiology OBSOLETE. functional anomaly of this protein secreted by macrophages and is chemotactic for neutrophils and T cells http://purl.obolibrary.org/obo/MP_0002528 obsolete abnormal interleukin-1 physiology OBSOLETE. functional anomaly of this soluble factor produced by macrophages/monocytes that activates vascular endothelium and lymphocytes http://purl.obolibrary.org/obo/MP_0002529 obsolete abnormal interleukin physiology OBSOLETE. functional anomaly of any of the cytokines produced by leukocytes http://purl.obolibrary.org/obo/MP_0002530 obsolete abnormal tumor necrosis factor physiology OBSOLETE. functional anomaly of this cytokine produced by macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium http://purl.obolibrary.org/obo/MP_0002535 obsolete combined T cell/ B cell deficiency OBSOLETE. Use cell-mediated immunity instead. defective or absent host defense involving both B and T cells http://purl.obolibrary.org/obo/MP_0002536 obsolete severe combined immunodeficiency disease OBSOLETE. rare congenital disorder characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels http://purl.obolibrary.org/obo/MP_0002538 obsolete Di George syndrome OBSOLETE. congenital syndrome with absence of thymus and parathyroids, causing impaired cellular immunity; immunoglobulin levels are normal http://purl.obolibrary.org/obo/MP_0002539 obsolete B cell deficiency OBSOLETE. defective or absent host defense involving B cells http://purl.obolibrary.org/obo/MP_0002540 obsolete congenital X-linked infantile hypogammaglobulinemia OBSOLETE. an immunologic deficiency state characterized by very low level of generally all classes of gamma-immunoglobulins http://purl.obolibrary.org/obo/MP_0002541 obsolete selective IgA deficiency OBSOLETE. an immunologic deficiency state characterized by very low levels of the immunoglobulin class A http://purl.obolibrary.org/obo/MP_0002552 obsolete abnormal response to addictive substance OBSOLETE. aberrant behavioral or physiological reaction to an addictive substance http://purl.obolibrary.org/obo/MP_0002567 obsolete abnormal odor preference OBSOLETE. http://purl.obolibrary.org/obo/MP_0002568 obsolete addiction/drug abuse OBSOLETE. http://purl.obolibrary.org/obo/MP_0002585 obsolete abnormal response/metabolism to xenobiotics OBSOLETE. altered ability or inability to metabolize or respond to foreign substances http://purl.obolibrary.org/obo/MP_0002587 obsolete heart/cardiovascular system: characteristics OBSOLETE. http://purl.obolibrary.org/obo/MP_0002588 obsolete blood cell characteristics OBSOLETE. http://purl.obolibrary.org/obo/MP_0002589 obsolete mean corpuscular volume traits OBSOLETE. http://purl.obolibrary.org/obo/MP_0002592 obsolete mean erythrocyte count traits OBSOLETE. http://purl.obolibrary.org/obo/MP_0002597 obsolete platelet traits OBSOLETE. http://purl.obolibrary.org/obo/MP_0002598 obsolete mean platelet volume traits OBSOLETE. http://purl.obolibrary.org/obo/MP_0002600 obsolete mean leukocyte count traits OBSOLETE. http://purl.obolibrary.org/obo/MP_0002601 obsolete lymphocyte count traits OBSOLETE. http://purl.obolibrary.org/obo/MP_0002603 obsolete basophil count traits OBSOLETE. http://purl.obolibrary.org/obo/MP_0002604 obsolete neutrophil count traits OBSOLETE. http://purl.obolibrary.org/obo/MP_0002605 obsolete monocyte count traits OBSOLETE. http://purl.obolibrary.org/obo/MP_0002609 obsolete blood physiology traits OBSOLETE. http://purl.obolibrary.org/obo/MP_0002610 obsolete blood chemistry traits OBSOLETE. http://purl.obolibrary.org/obo/MP_0002611 obsolete glucose homeostasis traits OBSOLETE. http://purl.obolibrary.org/obo/MP_0002614 obsolete lipid homeostasis traits OBSOLETE. http://purl.obolibrary.org/obo/MP_0002688 obsolete increased sensitivity to addictive substance OBSOLETE. decreased threshold to obtain a physiological or behavioral response to an addictive substance http://purl.obolibrary.org/obo/MP_0002720 obsolete urogenital system: dysmorphology OBSOLETE. abnormal development of the urogenital system resulting in morphological abnormality http://purl.obolibrary.org/obo/MP_0002721 obsolete abnormal urogenital system physiology OBSOLETE. http://purl.obolibrary.org/obo/MP_0002756 obsolete decreased pyramidal neuron number OBSOLETE. fewer than average number of projection neurons in the hippocampus http://purl.obolibrary.org/obo/MP_0002760 obsolete ectopic pyramidal neurons OBSOLETE. abnormal position of one or more triangular shaped projection neurons in the hippocampus http://purl.obolibrary.org/obo/MP_0002848 obsolete increased surface glomeruli OBSOLETE. http://purl.obolibrary.org/obo/MP_0002930 obsolete hair cell degeneration OBSOLETE. a retrogressive impairment of function, destruction or apoptosis of the sensory epithelial cells of the inner ear http://purl.obolibrary.org/obo/MP_0002949 obsolete abnormal neural crest cells OBSOLETE. defect in the transient and migratory group of cells that emerge from the dorsal region of the neural tube and disperse to many peripheral locations to form various tissues of the adult http://purl.obolibrary.org/obo/MP_0002954 obsolete abnormal aerobic energy metabolism OBSOLETE. defect in respiratory chain energy production (oxidative metabolism) process in all living cells where oxygen is consumed and carbon dioxide and water are produced http://purl.obolibrary.org/obo/MP_0002977 obsolete abnormal patterning of the aortic arch OBSOLETE. abnormal development or differentiation of the convex portion of the aorta between the ascending and descending parts of the aorta http://purl.obolibrary.org/obo/MP_0002979 obsolete abnormal vestibular response OBSOLETE. abnormal response to changes in motion http://purl.obolibrary.org/obo/MP_0003045 obsolete fibrosis invasion of fibrous connective tissue into any organ or multiple organs, often resulting from inflammation or injury http://purl.obolibrary.org/obo/MP_0003118 obsolete abnormal tracheal-bronchial branching morphogenesis OBSOLETE. partial or complete failure of the trachea and bronchi to repeatedly divide during development of the lung http://purl.obolibrary.org/obo/MP_0003183 obsolete abnormal peptide metabolism anomaly in the biochemical modification and homeostasis of molecules consisting of linked amino acids and their derivatives http://purl.obolibrary.org/obo/MP_0003187 obsolete increased reduction OBSOLETE. http://purl.obolibrary.org/obo/MP_0003188 obsolete decreased reduction OBSOLETE. http://purl.obolibrary.org/obo/MP_0003263 obsolete abnormal cholesterol biosynthesis OBSOLETE. altered ability to form cholesterol from constituent compounds http://purl.obolibrary.org/obo/MP_0003264 obsolete increased cholesterol biosynthesis OBSOLETE. augmented rate at which cholesterol is formed from constituent compounds http://purl.obolibrary.org/obo/MP_0003265 obsolete decreased cholesterol biosynthesis OBSOLETE. reduced rate at which cholesterol is formed from constituent compounds http://purl.obolibrary.org/obo/MP_0003386 obsolete increased sensitivity to nicotine OBSOLETE. decreased threshold to obtain a physiological or behavioral response to nicotine http://purl.obolibrary.org/obo/MP_0003636 obsolete absence of hair cells OBSOLETE. absence of the sensory epithelial cells of the inner ear http://purl.obolibrary.org/obo/MP_0003744 obsolete abnormal orofacial morphology any structural anomaly of the the mouth and the face http://purl.obolibrary.org/obo/MP_0003788 obsolete abnormal interferon physiology OBSOLETE. impairment or increase of the cellular release of any of the cytokines produced by T cells, fibroblasts and other cells in response to a challenge by a foreign agents such as viruses, bacteria, parasites and tumor cells http://purl.obolibrary.org/obo/MP_0003801 obsolete deviant histocompatibility locus OBSOLETE. deviation from the parental type of histocompatibility http://purl.obolibrary.org/obo/MP_0003802 obsolete deviant class I histocompatibility locus OBSOLETE. deviation from the parental type of class I histocompatibility http://purl.obolibrary.org/obo/MP_0003803 obsolete deviant class II histocompatibility locus OBSOLETE. deviation from the parental type of class II histocompatibility http://purl.obolibrary.org/obo/MP_0003804 obsolete deviant minor histocompatibility locus OBSOLETE. deviation from the parental type of minor histocompatibility http://purl.obolibrary.org/obo/MP_0003805 obsolete deviant histocompatibility-related locus OBSOLETE. deviation from the parental type of a histocompatibility-related locus http://purl.obolibrary.org/obo/MP_0003876 obsolete abnormal cerebral function OBSOLETE. anomalous activity of the thin layer of grey matter on the surface of the cerebral hemisphere that develops from the telencephalon and folds into gyri that is responsible for higher mental functions http://purl.obolibrary.org/obo/MP_0003919 obsolete abnormal lymph node cellularity OBSOLETE. anomaly in the cellular make up of the lymph nodes http://purl.obolibrary.org/obo/MP_0003937 obsolete abnormal limbs/digits/tail development OBSOLETE. anomaly of the formation of the digits, autopod, limbs, or tail http://purl.obolibrary.org/obo/MP_0004048 obsolete increased resistance to addictive substance OBSOLETE. increased threshold to obtain a physiological or behavioral response to an addictive substance http://purl.obolibrary.org/obo/MP_0004763 obsolete absent brainstem auditory evoked potential absence of the synchronous electrical activity generated by neurons in the ascending auditory system that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts; by varying frequency, cochlear function can be assessed throughout the hearing range; normally, ABR thresholds vary with frequency, from a sound pressure level (SPL) of 35 dB at 5.6 kHz (a relatively low frequency for a mouse) to 15 dB at 45.2 kHz (a relatively high frequency); each 20 dB corresponds to a tenfold change in amplitude http://purl.obolibrary.org/obo/MP_0004764 obsolete increased brainstem auditory evoked potential greater synchronous electrical activity generated by neurons in the ascending auditory system that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts; by varying frequency, cochlear function can be assessed throughout the hearing range; normally, ABR thresholds vary with frequency, from a sound pressure level (SPL) of 35 dB at 5.6 kHz (a relatively low frequency for a mouse) to 15 dB at 45.2 kHz (a relatively high frequency); each 20 dB corresponds to a tenfold change in amplitude; decreases in auditory thresholds required to generate a response may indicate a increased potential http://purl.obolibrary.org/obo/MP_0004765 obsolete decreased brainstem auditory evoked potential reduction in the synchronous electrical activity generated by neurons in the ascending auditory system that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts; by varying frequency, cochlear function can be assessed throughout the hearing range; normally, ABR thresholds vary with frequency, from a sound pressure level (SPL) of 35 dB at 5.6 kHz (a relatively low frequency for a mouse) to 15 dB at 45.2 kHz (a relatively high frequency); each 20 dB corresponds to a tenfold change in amplitude; increases in auditory thresholds required to generate a response may indicate a decreased potential http://purl.obolibrary.org/obo/MP_0005003 obsolete B cell clonal deletion abnormalities OBSOLETE. a defect in the process of removal of immature B lymphocytes that interact with self antigens during maturation http://purl.obolibrary.org/obo/MP_0005009 obsolete congenital skeletal deformities OBSOLETE. malformations of the bones/skeleton existing at birth http://purl.obolibrary.org/obo/MP_0005021 obsolete B lymphoblast abnormalities OBSOLETE. http://purl.obolibrary.org/obo/MP_0005049 obsolete abnormal cytokine physiology OBSOLETE. functional anomaly of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells http://purl.obolibrary.org/obo/MP_0005050 obsolete abnormal chemotactic interleukin physiology OBSOLETE. functional anomaly of any of a subset of interleukins that are involved in attracting leukocytes to a site of tissue injury http://purl.obolibrary.org/obo/MP_0005051 obsolete altered response to anesthetics OBSOLETE. a reaction that differs from normal to compounds that reversibly depress neuronal function http://purl.obolibrary.org/obo/MP_0005052 obsolete increased sleep after pentobarbital treatment OBSOLETE. http://purl.obolibrary.org/obo/MP_0005053 obsolete altered response to pentobarbital OBSOLETE. a reaction to pentobarbital that differs from normal http://purl.obolibrary.org/obo/MP_0005054 obsolete altered response to tribromoethanol OBSOLETE. a reaction to tribromoethanol that differs from normal http://purl.obolibrary.org/obo/MP_0005055 obsolete altered response to alphaxalone OBSOLETE. a reaction to alphaxalone that differs from controls http://purl.obolibrary.org/obo/MP_0005056 obsolete increased sleep after tribromoethanol treatment OBSOLETE. http://purl.obolibrary.org/obo/MP_0005057 obsolete increased sleep after alphaxalone treatment OBSOLETE. http://purl.obolibrary.org/obo/MP_0005062 obsolete presence of giant granules in eosinophils OBSOLETE. http://purl.obolibrary.org/obo/MP_0005064 obsolete presence of giant granules in lymphocytes OBSOLETE. http://purl.obolibrary.org/obo/MP_0005066 obsolete presence of giant granules in neutrophils OBSOLETE. http://purl.obolibrary.org/obo/MP_0005067 obsolete presence of melanin granules in retina OBSOLETE. pigment particles found in retina http://purl.obolibrary.org/obo/MP_0005196 obsolete abnormal posterior uvea morphology any structural anomaly of the rear, or dorsal, portion of the vascular, pigmentary, or middle coat of the eye, includes the choroid http://purl.obolibrary.org/obo/MP_0005212 obsolete immature goblet-like cells in stomach OBSOLETE. unusual appearance of stomach mucosa in which one finds cells resembling those that produce and secrete mucins http://purl.obolibrary.org/obo/MP_0005228 obsolete abnormal fusion of vertebral bodies/neural arches OBSOLETE. improper joining of the main portion of the vertebra anterior to the vertebral canal and the cartilaginous or bony arch that encloses and protects the spinal cord on the back http://purl.obolibrary.org/obo/MP_0005235 obsolete abnormal olfactory pathway morphology OBSOLETE. any structural anomaly of any of the set of nerve fibers conducting impulses from olfactory receptors to the cerebral cortex, including the olfactory nerve; olfactory bulb; olfactory tract, olfactory tubercle, anterior perforated substance, and olfactory cortex http://purl.obolibrary.org/obo/MP_0005349 obsolete abnormal interleukin-6 physiology OBSOLETE. functional anomaly of this soluble factor produced by B- and T-cells, with effects on T- and B-cell growth and differentiation, and in acute phase reactions http://purl.obolibrary.org/obo/MP_0005428 obsolete abnormal clinical chemistry OBSOLETE. any anomaly in the laboratory tests that show the presence of physiologically significant substances in the blood, urine, tissue, and body fluids with application to the diagnosis or therapy of disease http://purl.obolibrary.org/obo/MP_0005429 obsolete abnormal pine bedding color after urinary excretion OBSOLETE. with normal urine coloration, a change in the hue of the pine bedding of a mouse, often to a bright yellow or chartreuse, after excretion of urine by the animal housed with this type of bedding; indicative of a metabolic defect http://purl.obolibrary.org/obo/MP_0005442 obsolete abnormal pyramidal neuron morphology OBSOLETE. any structural anomaly of the projection neurons in the cerebral cortex and hippocampus http://purl.obolibrary.org/obo/MP_0005456 obsolete weight gain OBSOLETE. increase in weight over existing weight http://purl.obolibrary.org/obo/MP_0005467 obsolete abnormal chemotactic leukotriene physiology OBSOLETE. functional anomaly of any of a subset of leukotrienes that are involved in attracting leukocytes to a site of tissue injury http://purl.obolibrary.org/obo/MP_0005482 obsolete cellular hypertrophy OBSOLETE. increased size or bulk of a cell, without accompanying increased numbers http://purl.obolibrary.org/obo/MP_0005483 obsolete cellular hyperplasia OBSOLETE. an increase in the number of cells in an organ or tissue http://purl.obolibrary.org/obo/MP_0005485 obsolete cellular dysplasia OBSOLETE. change in the size, shape, and organization of the cellular components of a tissue http://purl.obolibrary.org/obo/MP_0005486 obsolete cellular metaplasia OBSOLETE. conversion of one differentiated cell type to another http://purl.obolibrary.org/obo/MP_0005487 obsolete cellular hypoplasia OBSOLETE. a decrease in the number of cells in an organ or tissue http://purl.obolibrary.org/obo/MP_0005506 obsolete abnormal limbs/digits/tail physiology OBSOLETE. functional anomaly of the digits, paws, limbs, or tail http://purl.obolibrary.org/obo/MP_0005550 obsolete orbital hemorrhage OBSOLETE. escape of blood into the orbit http://purl.obolibrary.org/obo/MP_0005552 obsolete abnormal orbital bone morphology OBSOLETE. structural anomaly of the bony cavity that contains the eyeball and is formed by parts of eight bones in the mouse: maxilla, lacrimal, zygomatic, frontal, temporal, sphenoid, ethmoid, palatine http://purl.obolibrary.org/obo/MP_0006004 obsolete abnormal interneuron morphology OBSOLETE. any structural anomaly of neurons that exclusively interact with other neurons http://purl.obolibrary.org/obo/MP_0006005 obsolete decreased interneuron number OBSOLETE. fewer than normal number of neurons that interact only with other neurons http://purl.obolibrary.org/obo/MP_0006028 obsolete impaired bronchiole branching OBSOLETE. a block or reduction in the morphogenesis of the bronchioles http://purl.obolibrary.org/obo/MP_0006040 obsolete increased mitochondrial oxidation OBSOLETE. greater than normal activity of the process in mitochondria that produces ATP http://purl.obolibrary.org/obo/MP_0006041 obsolete decreased mitochondrial oxidation OBSOLETE. less than normal activity of the mitochondrial process that produces ATP http://purl.obolibrary.org/obo/MP_0006297 obsolete loss of abdominal adipose tissue OBSOLETE. reduction in amount or absence of adipose tissue associated with internal organs http://purl.obolibrary.org/obo/MP_0006374 obsolete abnormal blood osmolality OBSOLETE. anomaly in the concentration of ions in the blood http://purl.obolibrary.org/obo/MP_0008084 obsolete absent single-positive T cells absence of T cells bearing either CD4 or CD8 markers on their surface http://purl.obolibrary.org/obo/MP_0008229 obsolete abnormal pars posterior morphology OBSOLETE. any structural anomaly of the horseshoe-shaped tract that connects the two olfactory bulbs http://purl.obolibrary.org/obo/MP_0008230 obsolete abnormal pars anterior morphology OBSOLETE. any structural anomaly of the major forebrain commissure that connects the two temporal lobes of the cortex http://purl.obolibrary.org/obo/MP_0008239 obsolete epigenetic coat coloration OBSOLETE. a range of wild-type and mutant allele coat coloration, from mouse to mouse or coat color mosaicism of an individual mouse, due to differential methylation of the mutation causing element http://purl.obolibrary.org/obo/MP_0009383 obsolete abnormal truncus arteriosus morphology OBSOLETE. any structural anomaly of the common arterial trunk opening out of both ventricles that divides into the aorta and pulmonary artery during development http://purl.obolibrary.org/obo/MP_0011023 obsolete absent motile cilia OBSOLETE. absence of cilia which have a variable arrangement, often with a 9 + 2 microtubular arrangement, of axonemal microtubules, contain molecular motors, and beat with a characteristic whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface; motile cilia are typically found in multiple copies on epithelial cells that line the lumenal ducts of various tissues http://purl.obolibrary.org/obo/BFO_0000002 continuant An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts. http://purl.obolibrary.org/obo/ENVO_00002297 environmental feature http://purl.obolibrary.org/obo/HP_0000001 All http://purl.obolibrary.org/obo/ENVO_00010483 environmental material http://purl.obolibrary.org/obo/GO_0005575 cellular_component http://purl.obolibrary.org/obo/CHEBI_24127 fungicide http://purl.obolibrary.org/obo/CHEBI_33281 antimicrobial agent A substance used to destroy fungal pests. http://purl.obolibrary.org/obo/CHEBI_33286 agrochemical http://purl.obolibrary.org/obo/CHEBI_33232 application An agrochemical is a substance that is used in agriculture or horticulture. http://purl.obolibrary.org/obo/CHEBI_50919 antiemetic http://purl.obolibrary.org/obo/CHEBI_23888 drug A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centers (the vomiting center and the chemoreceptive trigger zone) or affect the peripheral receptors. http://purl.obolibrary.org/obo/CHEBI_48425 topical anaesthetic http://purl.obolibrary.org/obo/CHEBI_36333 local anaesthetic A local anesthetic that is used to numb the surface of a body part. http://purl.obolibrary.org/obo/CHEBI_59683 antipruritic drug http://purl.obolibrary.org/obo/CHEBI_50177 dermatologic drug A drug, usually applied topically, that relieves pruritus (itching). http://purl.obolibrary.org/obo/CHEBI_48706 antagonist http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role Substance that attaches to and blocks cell receptors that normally bind naturally occurring substances. http://purl.obolibrary.org/obo/CHEBI_59544 phosphoantigen http://purl.obolibrary.org/obo/CHEBI_59132 antigen Any antigen that is a phosphorylated microbial metabolite which activates an immune response in humans. http://purl.obolibrary.org/obo/CHEBI_33289 avicide http://purl.obolibrary.org/obo/CHEBI_25944 pesticide A substance used to destroy bird pests (class Aves). http://purl.obolibrary.org/obo/CHEBI_35816 leprostatic drug http://purl.obolibrary.org/obo/CHEBI_64912 antimycobacterial drug A substance that suppresses Mycobacterium leprae, ameliorates the clinical manifestations of leprosy, and/or reduces the incidence and severity of leprous reactions. http://purl.obolibrary.org/obo/CHEBI_35818 coccidiostat http://purl.obolibrary.org/obo/CHEBI_35820 antiprotozoal drug An agent useful in the treatment or prevention of coccidiosis in man or animals. http://purl.obolibrary.org/obo/CHEBI_35842 antirheumatic drug http://purl.obolibrary.org/obo/CHEBI_23888 drug A drug used to treat rheumatoid arthritis. http://purl.obolibrary.org/obo/CHEBI_36333 local anaesthetic http://purl.obolibrary.org/obo/CHEBI_38867 anaesthetic Any member of a group of drugs that reversibly inhibit the propagation of signals along nerves. Wide variations in potency, stability, toxicity, water-solubility and duration of action determine the route used for administration, e.g. topical, intravenous, epidural or spinal block. http://purl.obolibrary.org/obo/CHEBI_37416 RNA polymerase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of RNA polymerase (EC 2.7.7.6) http://purl.obolibrary.org/obo/CHEBI_37955 H1-receptor antagonist http://purl.obolibrary.org/obo/CHEBI_37956 histamine antagonist H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine. http://purl.obolibrary.org/obo/CHEBI_38323 cholinergic drug http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent Any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of acetylcholine, and drugs that affect the survival of cholinergic neurons. http://purl.obolibrary.org/obo/CHEBI_39442 fluorescent probe http://purl.obolibrary.org/obo/CHEBI_50406 probe A role played by a fluorescent molecular entity used to study the microscopic environment by fluorescence spectroscopy. http://purl.obolibrary.org/obo/CHEBI_50635 urease inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Compound that, by one mechanism or another, interferes with urease activity and reduces urea hydrolysis. http://purl.obolibrary.org/obo/CHEBI_51068 miotic http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent Aa agent causing contraction of the pupil of the eye. Because the size of the pupil is under the antagonistic control of the sympathetic and parasympathetic systems, drugs affecting either system can cause miosis. Drugs that mimic or potentiate the parasympathetic input to the circular constrictor muscle and drugs that inhibit sympathetic input to the radial dilator muscle tend to contract the pupils. http://purl.obolibrary.org/obo/CHEBI_52303 sterol methyltransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of sterol methyltransferase. http://purl.obolibrary.org/obo/CHEBI_53142 P2Y2 receptor agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist A compound that exhibits agonist activity at the P2Y2 receptor. http://purl.obolibrary.org/obo/CHEBI_60901 riboflavin synthetase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any compound that inhibits the action of riboflavin synthetase. http://purl.obolibrary.org/obo/CHEBI_63932 tyrosine 3-monooxygenase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of tyrosine 3-monooxygenase. http://purl.obolibrary.org/obo/CHEBI_64047 food additive http://purl.obolibrary.org/obo/CHEBI_33232 application Any substance which is added to food to preserve or enhance its flavour and/or appearance. http://purl.obolibrary.org/obo/CHEBI_64176 H3-receptor antagonist http://purl.obolibrary.org/obo/CHEBI_37956 histamine antagonist A histamine antagonist that selectively binds to but does not activate histamine H3 receptors, thereby blocking the actions of endogenous histamine. http://purl.obolibrary.org/obo/CHEBI_64933 melanin synthesis inhibitor http://purl.obolibrary.org/obo/CHEBI_59864 depigmentation drug A depigmentation agent which inhibits the synthesis of melanin. http://purl.obolibrary.org/obo/CHEBI_64946 anti-HIV agent http://purl.obolibrary.org/obo/CHEBI_22587 antiviral agent An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus. http://purl.obolibrary.org/obo/CHEBI_65190 first generation antipsychotic http://purl.obolibrary.org/obo/CHEBI_35476 antipsychotic agent Antipsychotic drugs which can have different modes of action but which tend to be more likely than second generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements; such body movements can become permanent even after treatment has ceased. http://purl.obolibrary.org/obo/CHEBI_71232 adenosine receptor antagonist http://purl.obolibrary.org/obo/CHEBI_48706 antagonist An antagonist at any adenosine receptor. http://purl.obolibrary.org/obo/CHEBI_73190 antimutagen http://purl.obolibrary.org/obo/CHEBI_24432 biological role An agent that reduces or interferes with the mutagenic actions or effects of a substance. http://purl.obolibrary.org/obo/CHEBI_74530 antidote to curare poisoning http://purl.obolibrary.org/obo/CHEBI_50247 antidote A role borne by a molecule that acts to counteract or neutralize the deleterious effects of curare. http://purl.obolibrary.org/obo/CHEBI_75358 curing agent http://purl.obolibrary.org/obo/CHEBI_33232 application A chemical additive used to toughen or harden a polymer material by cross-linking of polymer chains. http://purl.obolibrary.org/obo/CHEBI_35197 lumiphore http://purl.obolibrary.org/obo/CHEBI_52215 photochemical role A part of a molecular entity (atom or group of atoms) in which electronic excitation associated with a given emission band is approximately localized. http://purl.obolibrary.org/obo/CHEBI_35205 chemical tracer http://purl.obolibrary.org/obo/CHEBI_35204 tracer A role played by a chemical compound with properties similar to those of the substance being traced with which it is mixed homogeneously. http://purl.obolibrary.org/obo/CHEBI_35206 isotopic tracer http://purl.obolibrary.org/obo/CHEBI_35204 tracer A tracer which only differs in isotopic composition from the substance to be traced. http://purl.obolibrary.org/obo/CHEBI_35207 radioactive tracer http://purl.obolibrary.org/obo/CHEBI_35204 tracer A tracer containing a radioactive label. http://purl.obolibrary.org/obo/CHEBI_35208 physical tracer http://purl.obolibrary.org/obo/CHEBI_35204 tracer A physical tracer is one that is attached by physical means to the object being traced. http://purl.obolibrary.org/obo/CHEBI_35209 label http://purl.obolibrary.org/obo/CHEBI_33232 application A role played by a part of a molecular entity distinguishable by the observer but not by the system and used to identify a tracer. http://purl.obolibrary.org/obo/CHEBI_35210 spin label http://purl.obolibrary.org/obo/CHEBI_35209 label A role played by a stable paramagnetic group that is attached to a part of a molecular entity whose microscopic environment is of interest and may be revealed by the electron spin resonance (ESR) spectroscopy. http://purl.obolibrary.org/obo/CHEBI_35220 primary metabolite http://purl.obolibrary.org/obo/CHEBI_25212 metabolite A metabolite that is directly involved in the normal growth, development or reproduction of an organism. http://purl.obolibrary.org/obo/CHEBI_35226 spin probe http://purl.obolibrary.org/obo/CHEBI_50406 probe A role played by a stable paramagnetic molecular entity used to study the microscopic environment by electron paramagnetic resonance (EPR) spectroscopy without covalent attachment to the molecular entity of interest. http://purl.obolibrary.org/obo/CHEBI_35231 nuclear fuel http://purl.obolibrary.org/obo/CHEBI_33292 fuel Material containing fissile nuclides, which when placed in a reactor, enables a chain reaction to be achieved. http://purl.obolibrary.org/obo/CHEBI_35232 radiopharmaceutical http://purl.obolibrary.org/obo/CHEBI_52217 pharmaceutical Any pharmaceutical compound containing a radioisotope. http://purl.obolibrary.org/obo/CHEBI_35473 tranquilizing drug http://purl.obolibrary.org/obo/CHEBI_35488 central nervous system depressant A traditional grouping of drugs said to have a soothing or calming effect on mood, thought or behaviour. http://purl.obolibrary.org/obo/CHEBI_35841 uricosuric drug http://purl.obolibrary.org/obo/CHEBI_35846 renal agent A gout suppressant that acts directly on the renal tubule to increase the excretion of uric acid, thus reducing its concentrations in plasma. http://purl.obolibrary.org/obo/CHEBI_35845 gout suppressant http://purl.obolibrary.org/obo/CHEBI_35842 antirheumatic drug A drug that increases uric acid excretion by the kidney (uricosuric drug), decreases uric acid production (antihyperuricemic), or alleviates the pain and inflammation of acute attacks of gout. http://purl.obolibrary.org/obo/CHEBI_35846 renal agent http://purl.obolibrary.org/obo/CHEBI_23888 drug A drug used for its effect on the kidneys' regulation of body fluid composition and volume. http://purl.obolibrary.org/obo/CHEBI_36050 antitreponemal drug http://purl.obolibrary.org/obo/CHEBI_36047 antibacterial drug A drug used in the treatment of infections with bacteria of the genus Treponema. http://purl.obolibrary.org/obo/CHEBI_36051 antisyphilitic drug http://purl.obolibrary.org/obo/CHEBI_36050 antitreponemal drug A substance that is used in the treatment of syphilis. http://purl.obolibrary.org/obo/CHEBI_36053 acaricide drug http://purl.obolibrary.org/obo/CHEBI_35442 antiparasitic agent A drug used to treat infestations with arthropods of the subclass Acari (mites and ticks). http://purl.obolibrary.org/obo/CHEBI_36710 interferon inducer http://purl.obolibrary.org/obo/CHEBI_23888 drug An agent that promotes the production and release of interferons. http://purl.obolibrary.org/obo/CHEBI_37957 histaminergic drug http://purl.obolibrary.org/obo/CHEBI_35942 neurotransmitter agent Drugs used for their actions on histaminergic systems. http://purl.obolibrary.org/obo/CHEBI_48540 beta-adrenergic drug http://purl.obolibrary.org/obo/CHEBI_37962 adrenergic agent Any of the drugs that act on beta-adrenergic receptors. http://purl.obolibrary.org/obo/CHEBI_52210 pharmacological role http://purl.obolibrary.org/obo/CHEBI_24432 biological role A biological role which describes how a drug interacts within a biological system and how the interactions affect its medicinal properties. http://purl.obolibrary.org/obo/CHEBI_71173 H1-receptor agonist http://purl.obolibrary.org/obo/CHEBI_35678 histamine agonist A histamine agonist that binds to and activates H1-receptors. http://purl.obolibrary.org/obo/CHEBI_62609 phosphonopyruvate hydrolase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of phosphonopyruvate hydrolase. http://purl.obolibrary.org/obo/CHEBI_63533 gonadotropin releasing hormone agonist http://purl.obolibrary.org/obo/CHEBI_51060 hormone agonist Any drug which binds to gonadotropin-releasing hormone receptors and triggers a response. http://purl.obolibrary.org/obo/CHEBI_64154 H3-receptor agonist http://purl.obolibrary.org/obo/CHEBI_35678 histamine agonist A histamine agonist that binds to and activates histamine H3-receptors. http://purl.obolibrary.org/obo/CHEBI_64155 H4-receptor agonist http://purl.obolibrary.org/obo/CHEBI_35678 histamine agonist A histamine agonist that binds to and activates H4-receptors. http://purl.obolibrary.org/obo/CHEBI_64371 neurotransmitter transporter modulator http://purl.obolibrary.org/obo/CHEBI_38632 membrane transport modulator A membrane transport modulator that affects the transport of neurotransmitters. http://purl.obolibrary.org/obo/CHEBI_64406 cathepsin K inhibitor http://purl.obolibrary.org/obo/CHEBI_64152 cysteine protease inhibitor A cysteine protease inhibitor which inhibits cathepsin K (EC 3.4.22.38). http://purl.obolibrary.org/obo/CHEBI_64411 geranylgeranyl diphosphate synthase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits the action of geranylgeranyl diphosphate synthase (EC 2.5.1.29). http://purl.obolibrary.org/obo/CHEBI_64696 acyl-CoA:cholesterol acyltransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of acyl-CoA:cholesterol acyltransferase. http://purl.obolibrary.org/obo/CHEBI_64919 diacylglycerol O-acyltransferase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits diacylglycerol O-acyltransferase (EC 2.3.1.20). http://purl.obolibrary.org/obo/CHEBI_64920 DNA ligase (ATP) inhibitor http://purl.obolibrary.org/obo/CHEBI_75605 phosphoric ester bond-forming ligase inhibitor A phosphoric ester bond-forming ligase inhibitor that inhibits the action of DNA ligase (ATP), EC 6.5.1.1. http://purl.obolibrary.org/obo/CHEBI_64943 chymotrypsin inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits the action of chymotrypsin (EC 3.4.21.1). http://purl.obolibrary.org/obo/CHEBI_64949 anti-HIV-2 agent http://purl.obolibrary.org/obo/CHEBI_64946 anti-HIV agent An anti-HIV agent that destroys or inhibits the replication of HIV-2, the less infective and less virulent of the two types of HIV virus. http://purl.obolibrary.org/obo/CHEBI_64952 anti-HSV agent http://purl.obolibrary.org/obo/CHEBI_22587 antiviral agent An antiviral agent that destroys or inhibits the replication of the herpes simplex virus (also known as the human herpes virus). http://purl.obolibrary.org/obo/CHEBI_64954 anti-HSV-2 agent http://purl.obolibrary.org/obo/CHEBI_64952 anti-HSV agent An anti-HSV agent agent that destroys or inhibits the replication of herpes simplex virus-2. http://purl.obolibrary.org/obo/CHEBI_64955 heparanase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of heparanase, EC 3.2.1.166. http://purl.obolibrary.org/obo/CHEBI_64957 chymase inhibitor http://purl.obolibrary.org/obo/CHEBI_37670 protease inhibitor A protease inhibitor that interferes with the action of chymase (EC 3.4.21.39). http://purl.obolibrary.org/obo/CHEBI_65239 golgi alpha-mannosidase II inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of golgi alpha-mannosidase II (mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase, EC 3.2.1.114), a key enzyme target in the development of anti-cancer therapies. http://purl.obolibrary.org/obo/CHEBI_65254 LRH-1 agonist http://purl.obolibrary.org/obo/CHEBI_48705 agonist An agonist that binds to and activates liver receptor homologue-1 (LRH-1). http://purl.obolibrary.org/obo/CHEBI_67268 HIV-1 integrase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An inhibitor of HIV-1 integrase, an enzyme required for the integration of the genetic material of the retrovirus into the DNA of the infected cells. http://purl.obolibrary.org/obo/CHEBI_71168 HIV-1 maturation inhibitor http://purl.obolibrary.org/obo/CHEBI_64947 anti-HIV-1 agent A compound that blocks the processing of the Gag precursor protein in HIV-1 by the viral protease enzyme, leading to the formation of noninfectious, immature virus particles that are incapable of infecting other cells. http://purl.obolibrary.org/obo/CHEBI_72571 pro-angiogenic agent http://purl.obolibrary.org/obo/CHEBI_50926 angiogenesis modulating agent Any compound that promotes the growth of new blood vessels from pre-existing vessels. http://purl.obolibrary.org/obo/CHEBI_75298 histamine releasing agent http://purl.obolibrary.org/obo/CHEBI_52206 biochemical role Any substance that can induce the release of histamine from mast cells. http://purl.obolibrary.org/obo/CHEBI_75324 excipient http://purl.obolibrary.org/obo/CHEBI_33232 application A generally pharmacologically inactive substance that is formulated with the active ingredient of a medication. http://purl.obolibrary.org/obo/CHEBI_75416 aminoacyl tRNA synthetase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any compound that inhibits the action of an aminoacyl tRNA synthetase. http://purl.obolibrary.org/obo/CHEBI_75495 seryl-tRNA synthetase inhibitor http://purl.obolibrary.org/obo/CHEBI_75416 aminoacyl tRNA synthetase inhibitor An aminoacyl tRNA synthetase inhibitor that specifically inhibits the action of seryl-tRNA synthetase. http://purl.obolibrary.org/obo/CHEBI_75595 alanine racemase inhibitor http://purl.obolibrary.org/obo/CHEBI_75596 isomerase inhibitor Any compound that inhibits the action of alanine racemase (EC 5.1.1.1). http://purl.obolibrary.org/obo/CHEBI_75596 isomerase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that inhibits the action of an isomerase (EC 5.*.*.*). http://purl.obolibrary.org/obo/CHEBI_75598 D-alanine--D-alanine ligase inhibitor http://purl.obolibrary.org/obo/CHEBI_59105 acid--amino-acid ligase inhibitor An acid--amino-acid ligase inhibitor that inhibits the action of a D-alanine--D-alanine ligase (EC 6.3.2.4). http://purl.obolibrary.org/obo/CHEBI_75603 ligase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor Any enzyme inhibitor that inhibits a ligase (EC 6.*.*.*). Ligases are enzymes that catalyse the joining of two molecules with concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. http://purl.obolibrary.org/obo/CHEBI_75604 C-C bond-forming ligase inhibitor http://purl.obolibrary.org/obo/CHEBI_75603 ligase inhibitor Any inhibitor of a C-C bond-forming ligase (EC 6.4.*.*). http://purl.obolibrary.org/obo/CHEBI_75605 phosphoric ester bond-forming ligase inhibitor http://purl.obolibrary.org/obo/CHEBI_75603 ligase inhibitor A ligase inhibitor which inhibits the action of a phosphoric ester bond-forming ligase (EC 6.5.*.*). http://purl.obolibrary.org/obo/CHEBI_75760 bacterial metabolite http://purl.obolibrary.org/obo/CHEBI_75787 prokaryotic metabolite Any prokaryotic metabolite produced during a metabolic reaction in a bacterium. http://purl.obolibrary.org/obo/CHEBI_75765 fungal metabolite http://purl.obolibrary.org/obo/CHEBI_75763 eukaryotic metabolite Any eukaryotic metabolite produced during a metabolic reaction in fungi, the kingdom that includes microorganisms such as the yeasts and moulds. http://purl.obolibrary.org/obo/CHEBI_75766 plant metabolite http://purl.obolibrary.org/obo/CHEBI_75763 eukaryotic metabolite Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms. http://purl.obolibrary.org/obo/CHEBI_75770 human metabolite http://purl.obolibrary.org/obo/CHEBI_75768 mammalian metabolite Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens). http://purl.obolibrary.org/obo/CHEBI_75787 prokaryotic metabolite http://purl.obolibrary.org/obo/CHEBI_25212 metabolite Any metabolite produced during a metabolic reaction in prokaryotes, the taxon that include members of the bacteria kingdom. http://purl.obolibrary.org/obo/CHEBI_75789 Streptococcus pneumoniae metabolite http://purl.obolibrary.org/obo/CHEBI_75760 bacterial metabolite Any bacterial metabolite produced during a metabolic reaction in Streptococcus pneumoniae. http://purl.obolibrary.org/obo/CHEBI_75864 Aspergillus metabolite http://purl.obolibrary.org/obo/CHEBI_75765 fungal metabolite Any fungal metabolite produced during a metabolic reaction in the mold, Aspergillus. http://purl.obolibrary.org/obo/CHEBI_75916 Chaetomium metabolite http://purl.obolibrary.org/obo/CHEBI_75765 fungal metabolite Any fungal metabolite produced during a metabolic reaction in the mold, Chaetomium. http://purl.obolibrary.org/obo/CHEBI_75968 Skp2 inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor An enzyme inhibitor that interferes with the action of S-phase kinase-associated protein 2 (Skp2). http://purl.obolibrary.org/obo/CHEBI_75997 mitogen-activated protein kinase inhibitor http://purl.obolibrary.org/obo/CHEBI_37699 protein kinase inhibitor Any protein kinase inhibitor that interferes with the action of mitogen-activated protein kinase. http://purl.obolibrary.org/obo/CHEBI_76022 soluble guanylate cyclase activator http://purl.obolibrary.org/obo/CHEBI_35224 effector An effector that binds to and activates soluble guanylate cyclase (EC 4.6.1.2). http://purl.obolibrary.org/obo/MP_0011459 increased urine chloride ion level http://purl.obolibrary.org/obo/MP_0011458 abnormal urine chloride ion level abnormally large amounts of chloride ion in the urine http://purl.obolibrary.org/obo/MP_0011460 decreased urine chloride ion level http://purl.obolibrary.org/obo/MP_0011458 abnormal urine chloride ion level abnormally low amounts of chloride ion in the urine http://purl.obolibrary.org/obo/MP_0011461 abnormal urine bicarbonate level http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis any change in the amount of bicarbonate in the urine http://purl.obolibrary.org/obo/MP_0011462 increased urine bicarbonate level http://purl.obolibrary.org/obo/MP_0011461 abnormal urine bicarbonate level an increased amount of bicarbonate in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0011463 decreased urine bicarbonate level http://purl.obolibrary.org/obo/MP_0011461 abnormal urine bicarbonate level a reduced amount of bicarbonate in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0011464 bilirubinuria http://purl.obolibrary.org/obo/MP_0002962 increased urine protein level presence of conjugated bilirubin in the urine http://purl.obolibrary.org/obo/MP_0011465 abnormal urine urea nitrogen level http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis any change in the amount of nitrogen in the form of urea in the urine http://purl.obolibrary.org/obo/MP_0011466 increased urine urea nitrogen level http://purl.obolibrary.org/obo/MP_0011465 abnormal urine urea nitrogen level abnormally high amounts of nitrogen in the form of urea in the urine http://purl.obolibrary.org/obo/MP_0011467 decreased urine urea nitrogen level http://purl.obolibrary.org/obo/MP_0011465 abnormal urine urea nitrogen level abnormally low amounts of nitrogen in the form of urea in the urine http://purl.obolibrary.org/obo/MP_0011469 abnormal urine creatinine level http://purl.obolibrary.org/obo/MP_0011468 abnormal urine amino acid level any change in the amount of creatinine in the urine http://purl.obolibrary.org/obo/MP_0011470 increased urine creatinine level http://purl.obolibrary.org/obo/MP_0011469 abnormal urine creatinine level an increased amount of creatinine in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0011471 decreased urine creatinine level http://purl.obolibrary.org/obo/MP_0011469 abnormal urine creatinine level a reduced amount of creatinine in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0011472 abnormal urine glycosaminoglycan level http://purl.obolibrary.org/obo/MP_0011475 abnormal glycosaminoglycan level any change in the amount of glycosaminoglycan in the urine, including chondroitin sulfate, dermatan sulfate, keratan sulfate, heparin sulfate, heparin, and/or hyaluronan and other long unbranched polysaccharides consisting of a repeating disaccharide unit http://purl.obolibrary.org/obo/MP_0011473 increased urine glycosaminoglycan level http://purl.obolibrary.org/obo/MP_0011472 abnormal urine glycosaminoglycan level greater in the amount of glycosaminoglycan in the urine, including chondroitin sulfate, dermatan sulfate, keratan sulfate, heparin sulfate, heparin, and/or hyaluronan and other long unbranched polysaccharides consisting of a repeating disaccharide unit http://purl.obolibrary.org/obo/MP_0011474 decreased urine glycosaminoglycan level http://purl.obolibrary.org/obo/MP_0011472 abnormal urine glycosaminoglycan level reduced amount of glycosaminoglycan in the urine, including chondroitin sulfate, dermatan sulfate, keratan sulfate, heparin sulfate, heparin, and/or hyaluronan and other long unbranched polysaccharides consisting of a repeating disaccharide unit http://purl.obolibrary.org/obo/MP_0011475 abnormal glycosaminoglycan level http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis any change in the amount of glycosaminoglycan, including chondroitin sulfate, dermatan sulfate, keratan sulfate, heparin sulfate, heparin, and/or hyaluronan and other long unbranched polysaccharides consisting of a repeating disaccharide unit http://purl.obolibrary.org/obo/MP_0011476 abnormal urine nucleotide level http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis any change in the urinary level of glycosamines consisting of a nucleobase, a five-carbon sugar moiety (ribose or deoxyribose), and may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates) http://purl.obolibrary.org/obo/MP_0011477 abnormal urine nucleoside level http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis any change in the urinary level of glycosylamines consisting of a nucleobase bound to a ribose or deoxyribose sugar via a beta-glycosidic linkage, including cytidine, uridine, adenosine, guanosine, thymidine and inosine and deoxynucleosides http://purl.obolibrary.org/obo/MP_0011478 abnormal urine catecholamine level http://purl.obolibrary.org/obo/MP_0011479 abnormal catecholamine level any anomaly in the urinary amount of catecholamines, including adrenaline, noradrenaline and L-dopamine; catecholamines are act as hormones or neurotransmitters and are derived from the amino acid tyrosine http://purl.obolibrary.org/obo/MP_0011480 impaired ureteric peristalsis http://purl.obolibrary.org/obo/MP_0003589 abnormal ureter physiology any anomaly in the wavelike sequence of involuntary muscular contraction and relaxation that passes along the ureter, thus propelling urine from the kidney pelvis to the urinary bladder http://purl.obolibrary.org/obo/MP_0011481 anterior iris synechia http://purl.obolibrary.org/obo/MP_0004222 iris synechia adhesion of the iris to the cornea http://purl.obolibrary.org/obo/MP_0011482 posterior iris synechia http://purl.obolibrary.org/obo/MP_0004222 iris synechia adhesion of the iris to the capsule of the lens or to the surface of the vitreous body http://purl.obolibrary.org/obo/MP_0011483 renal glomerular synechia http://purl.obolibrary.org/obo/MP_0005325 abnormal renal glomerulus morphology presence of adhesions (synechiae) between the Bowman's capsule and the glomerular tuft; may develop when areas of glomerular capillary basement membrane denuded of visceral epithelial cells come in contact with the parietal epithelium of Bowman's capsule http://purl.obolibrary.org/obo/MP_0011485 abnormal urethra urothelium morphology http://purl.obolibrary.org/obo/MP_0003630 abnormal urothelium morphology any structural anomaly of the epithelial lining of the luminal space of the urethra http://purl.obolibrary.org/obo/MP_0011486 ectopic ureter http://purl.obolibrary.org/obo/MP_0000534 abnormal ureter morphology an abnormally placed opening of the ureter, either into the urinary bladder or at another site in the lower urinary or genital tract; commonly a result of a duplicated renal collecting system, a duplex kidney with two ureters where usually one ureter terminates at the urinary bladder, while the duplicated ureter being ectopic, ends in the vagina, the urethra or the vulval vestibule http://purl.obolibrary.org/obo/MP_0011487 abnormal ureteropelvic junction morphology http://purl.obolibrary.org/obo/MP_0000516 abnormal renal/urinary system morphology any structural anomaly of the junction between the ureter and the renal pelvis of the kidney http://purl.obolibrary.org/obo/MP_0011488 abnormal ureterovesical junction morphology http://purl.obolibrary.org/obo/MP_0000516 abnormal renal/urinary system morphology any structural anomaly of the valve-like structure found at the site of entry of the ureter into the urinary bladder, normally displays an oblique angulation through the detrusor to avoid reflux of urine up the ureters and the kidney http://purl.obolibrary.org/obo/MP_0011489 ureteropelvic junction atresia http://purl.obolibrary.org/obo/MP_0011487 abnormal ureteropelvic junction morphology congenital absence or closure of the connection between the ureter and the renal pelvis http://purl.obolibrary.org/obo/MP_0011490 ureteropelvic junction stenosis http://purl.obolibrary.org/obo/MP_0011487 abnormal ureteropelvic junction morphology a constriction or narrowing of the junction between the ureter and the renal pelvis http://purl.obolibrary.org/obo/MP_0011491 ureteropelvic junction obstruction http://purl.obolibrary.org/obo/MP_0011487 abnormal ureteropelvic junction morphology a partial or total blockage of the flow of urine through the junction of the renal pelvis and the proximal ureter http://purl.obolibrary.org/obo/MP_0011492 ureterovesical junction obstruction http://purl.obolibrary.org/obo/MP_0011488 abnormal ureterovesical junction morphology a partial or total blockage of the valve-like structure found at the site of entry of the ureter into the urinary bladder http://purl.obolibrary.org/obo/MP_0011493 double ureter http://purl.obolibrary.org/obo/MP_0000534 abnormal ureter morphology two ureters open separately into the renal pelvis superiorly and drain separately into the urinary bladder or genital tract; if two ureteral buds arise from the Wolffian duct, a duplex kidney with complete ureteral duplication ensues where the additional ureter may result in a ureterocele, or an ectopic ureter http://purl.obolibrary.org/obo/MP_0011494 abnormal pigmentation pattern http://purl.obolibrary.org/obo/MP_0001186 pigmentation phenotype hair and/or skin coloration shows specific and consistent deviations from an expected display http://purl.obolibrary.org/obo/MP_0011498 abnormal glomerular capsule parietal layer morphology http://purl.obolibrary.org/obo/MP_0002828 abnormal renal glomerular capsule morphology any structural anomaly of the outer layer of the glomerular capsule composed of a single layer of simple squamous epithelium http://purl.obolibrary.org/obo/MP_0011499 abnormal glomerular capsule space morphology http://purl.obolibrary.org/obo/MP_0002828 abnormal renal glomerular capsule morphology any structural anomaly of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries http://purl.obolibrary.org/obo/MP_0011500 decreased glomerular capsule space http://purl.obolibrary.org/obo/MP_0011499 abnormal glomerular capsule space morphology reduced volume of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries http://purl.obolibrary.org/obo/MP_0011501 increased glomerular capsule space http://purl.obolibrary.org/obo/MP_0011499 abnormal glomerular capsule space morphology increased volume of the luminal region between the glomerular capsule visceral and parietal layers, into which filtrate enters after passing through the filtration barrier from the glomerular capillaries http://purl.obolibrary.org/obo/MP_0011502 parietal capsular epithelium metaplasia http://purl.obolibrary.org/obo/MP_0011498 abnormal glomerular capsule parietal layer morphology a metaplastic change or transformation of the single layer of the parietal epithelium of Bowman's capsule from the normal structural appearance of simple squamous epithelium to a cuboidal or low columnar epithelium; also referred to as a prominent parietal epithelium http://purl.obolibrary.org/obo/MP_0011503 distended jejunum http://purl.obolibrary.org/obo/MP_0004002 abnormal jejunum morphology an expansion in the volume of the portion of the small intestine that extends from the duodenum to the ileum http://purl.obolibrary.org/obo/MP_0011505 camptomelia http://purl.obolibrary.org/obo/MP_0011504 abnormal limb long bone morphology a skeletal dysplasia characterized by the bending of the long bones of the extremities http://purl.obolibrary.org/obo/MP_0011506 glomerular crescent http://purl.obolibrary.org/obo/MP_0005325 abnormal renal glomerulus morphology formation of a crescent-shaped (semi-lunar) glomerular lesion corresponding to extracapillary proliferation of Bowman's capsular epithelium and acquiring a fibroblast-like spindled morphology, possibly stimulated by release of fibrinogen from a ruptured glomerular basement membrane; epithelial crescents occur in aggressive forms of glomerulonephritis, may be accompanied by collagen and fibrin deposition and/or monocyte and macrophage proliferation, may protrude into Bowman's space, and ultimately compress and destroy the glomerular tuft http://purl.obolibrary.org/obo/MP_0011507 kidney thrombosis http://purl.obolibrary.org/obo/MP_0005048 thrombosis formation or presence of a thrombus within the blood vessel network of the organ of secretion http://purl.obolibrary.org/obo/MP_0011508 glomerular capillary thrombosis http://purl.obolibrary.org/obo/MP_0011507 kidney thrombosis formation or presence of a thrombus within the renal glomerular capillaries http://purl.obolibrary.org/obo/MP_0011509 dilated glomerular capillary http://purl.obolibrary.org/obo/MP_0011320 abnormal glomerular capillary morphology stretched or widened aperture of the luminal space of the small branching blood vessel in the kidney glomerulus that receives blood from the kidney afferent arteriole http://purl.obolibrary.org/obo/MP_0011512 mesangial cell interposition http://purl.obolibrary.org/obo/MP_0005327 abnormal mesangial cell morphology spreading of mesangial cells into the contiguous space between the adjacent glomerular endothelial cells and the glomerular basement membrane (GBM) http://purl.obolibrary.org/obo/MP_0011513 abnormal vertebral artery morphology http://purl.obolibrary.org/obo/MP_0011655 abnormal systemic artery morphology any structural anomaly of the first branch of the left and right subclavian arteries that merge to form the single midline basilar artery; branches of the vertebral arteries supply the musculature of the neck http://purl.obolibrary.org/obo/MP_0011515 purpura http://purl.obolibrary.org/obo/MP_0011514 skin hemorrhage a smooth, moderately sized hemorrhagic area, typically dark red to reddish purple, resulting from extarvasation of blood into the skin, mucous membrane, or serosal surface; a pupura becomes brown-yellow as it fades and does not blanch on applying pressure http://purl.obolibrary.org/obo/MP_0011516 aspartylglucosaminuria http://purl.obolibrary.org/obo/MP_0003311 aminoaciduria high urinary levels of aspartylglucosamine, a derivative of aspartic acid; caused by deficient activity of the enzyme N-aspartyl-beta-glucosaminidase (aspartylglucosaminidase) which normally cleaves long sugar chains known as oligosaccharides in the lysosome http://purl.obolibrary.org/obo/MP_0011517 hyperoxaluria http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis abnormally high levels of oxalic acid or oxalates in the urine; many metal ions form insoluble precipitates with oxalate, a prominent example being calcium oxalate, the primary constituent of the most common kind of kidney stones http://purl.obolibrary.org/obo/MP_0011519 abnormal placenta labyrinth size http://purl.obolibrary.org/obo/MP_0001716 abnormal placenta labyrinth morphology anomaly in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood http://purl.obolibrary.org/obo/MP_0011520 increased placental labyrinth size http://purl.obolibrary.org/obo/MP_0011519 abnormal placenta labyrinth size increase in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood http://purl.obolibrary.org/obo/MP_0011522 abnormal placental labyrinth villi morphology http://purl.obolibrary.org/obo/MP_0001716 abnormal placenta labyrinth morphology any structural anomaly of the vascularized and branched structures arising from the rodent trophoblast-derived epithelium that allow an increase its surface area for the efficient exchange of nutrients and wastes between the maternal and fetal circulation http://purl.obolibrary.org/obo/MP_0011523 thin placenta labyrinth http://purl.obolibrary.org/obo/MP_0011521 decreased placental labyrinth size decrease in the width of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood http://purl.obolibrary.org/obo/MP_0011524 thick placenta labyrinth http://purl.obolibrary.org/obo/MP_0011520 increased placental labyrinth size increase in the width of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood http://purl.obolibrary.org/obo/MP_0011525 abnormal placenta intervillous maternal lacunae morphology http://purl.obolibrary.org/obo/MP_0001716 abnormal placenta labyrinth morphology any structural anomaly of the spaces of the placenta occupied by maternal blood, into which the fetal labyrinth villi project http://purl.obolibrary.org/obo/MP_0011526 abnormal placenta fetal blood space morphology http://purl.obolibrary.org/obo/MP_0001716 abnormal placenta labyrinth morphology any structural anomaly of the spaces of the placenta occupied by fetal blood, primarily within the fetal labyrinth villi http://purl.obolibrary.org/obo/MP_0011527 disorganized placental labyrinth http://purl.obolibrary.org/obo/MP_0001716 abnormal placenta labyrinth morphology derangement of the placental layers where embryonic blood vessels are surrounded by trophoblast cells and maternal blood http://purl.obolibrary.org/obo/MP_0011528 abnormal placental labyrinth villi branching morphogenesis http://purl.obolibrary.org/obo/MP_0011522 abnormal placental labyrinth villi morphology any anomaly in the process in which the branches of the fetal placental villi are generated and organized from the trophoblast-derived epithelium http://purl.obolibrary.org/obo/MP_0011529 increased placenta intervillous maternal lacunae size http://purl.obolibrary.org/obo/MP_0011525 abnormal placenta intervillous maternal lacunae morphology increased size of the spaces of the placenta occupied by maternal blood, into which the fetal labyrinth villi project http://purl.obolibrary.org/obo/MP_0011530 fused radius and ulna http://purl.obolibrary.org/obo/MP_0005108 abnormal ulna morphology anomaly of the radius and ulna resulting in some portion of or all the two bones being merged together http://purl.obolibrary.org/obo/MP_0011531 abnormal syncytiotrophoblast morphology http://purl.obolibrary.org/obo/MP_0011522 abnormal placental labyrinth villi morphology any structural anomaly of the multi-nucleated, terminally differentiated syncytial epithelial layer of the placental villi that forms the major nutrient transport surfaces within the labyrinth layer of the rodent placenta http://purl.obolibrary.org/obo/MP_0011532 decreased urine major urinary protein level http://purl.obolibrary.org/obo/MP_0002963 decreased urine protein level reduced amount in the urine of a family of alpha2-microglobulin-related liver secretory proteins that comprise a major protein component of mouse urine http://purl.obolibrary.org/obo/MP_0011533 increased urine major urinary protein level http://purl.obolibrary.org/obo/MP_0002962 increased urine protein level increased amount in the urine of a family of alpha2-microglobulin-related liver secretory proteins that comprise a major protein component of mouse urine http://purl.obolibrary.org/obo/MP_0011534 granular kidney http://purl.obolibrary.org/obo/MP_0002135 abnormal kidney morphology a kidney in which fairly uniform, diffusely and evenly situated foci of scarring of the interstitial tissue of the cortex (and sometimes scarring of glomeruli), and the associated slight degree of bulging of groups of dilated tubules, leads to the development of a minutely bosselated surface; such kidneys are seen in arteriolar nephrosclerosis or chronic glomerulonephritis http://purl.obolibrary.org/obo/MP_0011535 increased urination frequency http://purl.obolibrary.org/obo/MP_0001761 abnormal urination pattern increased frequency of urination episodes; urination at short frequent intervals occurs without an increase in daily volume of urinary output and may be caused by reduced bladder capacity or urinary tract infection http://purl.obolibrary.org/obo/MP_0011536 decreased urination frequency http://purl.obolibrary.org/obo/MP_0001761 abnormal urination pattern decreased frequency of urination episodes; urination at long intervals occurs without an decrease in daily volume of urinary output http://purl.obolibrary.org/obo/MP_0011537 uraturia http://purl.obolibrary.org/obo/MP_0009810 increased urine uric acid level passage of an increased amount of any salt or ester of uric acid (urate) in the urine http://purl.obolibrary.org/obo/MP_0011538 abnormal urine hormone level http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis any change in the urine amount of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs http://purl.obolibrary.org/obo/MP_0011539 abnormal urine aldosterone level http://purl.obolibrary.org/obo/MP_0011538 abnormal urine hormone level any change in the urine amount of the hormone that is secreted by the adrenal cortex and regulates sodium conservation and potassium secretion in the distal renal tubule http://purl.obolibrary.org/obo/MP_0011540 increased urine aldosterone level http://purl.obolibrary.org/obo/MP_0011539 abnormal urine aldosterone level an increased amount of aldosterone in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0011541 decreased urine aldosterone level http://purl.obolibrary.org/obo/MP_0011539 abnormal urine aldosterone level a reduced amount of aldosterone in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0011542 abnormal urine antidiuretic hormone level http://purl.obolibrary.org/obo/MP_0011538 abnormal urine hormone level any change in the urine amount of the polypeptide hormone secreted by the posterior lobe of the pituitary gland (neurohypophysis) that increases mean arterial pressure by promoting vasoconstriction and reduces excretion of urine by increasing the reabsorption of water by the kidney tubules http://purl.obolibrary.org/obo/MP_0011543 increased urine antidiuretic hormone level http://purl.obolibrary.org/obo/MP_0011542 abnormal urine antidiuretic hormone level an increased amount of antidiuretic hormone in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0011544 decreased urine antidiuretic hormone level http://purl.obolibrary.org/obo/MP_0011542 abnormal urine antidiuretic hormone level a reduced amount of antidiuretic hormone in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0011545 abnormal urine progesterone level http://purl.obolibrary.org/obo/MP_0011538 abnormal urine hormone level any change in the urine amount of the antiestrogenic steroid released by the corpus luteum that stimulates the uterus to prepare for pregnancy http://purl.obolibrary.org/obo/MP_0011546 increased urine progesterone level http://purl.obolibrary.org/obo/MP_0011545 abnormal urine progesterone level an increased amount of progesterone in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0011547 decreased urine progesterone level http://purl.obolibrary.org/obo/MP_0011545 abnormal urine progesterone level a reduced amount of progesterone in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0011548 abnormal urine corticosterone level http://purl.obolibrary.org/obo/MP_0011538 abnormal urine hormone level any change in the urine amount of the corticosteroid produced in the adrenal cortex that induces glycogen deposition and regulates sodium conservation and potassium secretion http://purl.obolibrary.org/obo/MP_0011549 increased urine corticosterone level http://purl.obolibrary.org/obo/MP_0011548 abnormal urine corticosterone level an increased amount of corticosterone in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0011550 decreased urine corticosterone level http://purl.obolibrary.org/obo/MP_0011548 abnormal urine corticosterone level a reduced amount of corticosterone in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0011551 variegated eye pigmentation pattern http://purl.obolibrary.org/obo/MP_0001324 abnormal eye pigmentation an irregular and random patchwork of two or more colors in the eye http://purl.obolibrary.org/obo/MP_0011552 abnormal urine deoxycorticosterone level http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis any change in the urine amount of the steroid hormone secreted by the adrenal cortex, related to corticosterone and involved in regulating water and electrolyte balance http://purl.obolibrary.org/obo/MP_0011553 increased urine deoxycorticosterone level http://purl.obolibrary.org/obo/MP_0011552 abnormal urine deoxycorticosterone level an increased amount of deoxycorticosterone in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0011554 decreased urine deoxycorticosterone level http://purl.obolibrary.org/obo/MP_0011552 abnormal urine deoxycorticosterone level a reduced amount of deoxycorticosterone in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0011555 increased urine microglobulin level http://purl.obolibrary.org/obo/MP_0002962 increased urine protein level greater than the normal amount of any globulin (or any fragment of a globulin) of low molecular weight in the urine http://purl.obolibrary.org/obo/MP_0011556 increased urine beta2-microglobulin level http://purl.obolibrary.org/obo/MP_0011555 increased urine microglobulin level greater than the normal amount of beta2-microglobulin in the urine; may indicate renal tubule disease, drug-induced renal toxicity, heavy metal-induced renal disease, lymphomas, leukemia, or myeloma http://purl.obolibrary.org/obo/MP_0011557 increased susceptibility to induced choroid neovascularization http://purl.obolibrary.org/obo/MP_0005546 choroidal neovascularization increased rate or amount of new growth of new, abnormal blood vessels that originate in the choroid through a break in the Bruch membrane into the sub-retinal pigment epithelium or subretinal space and may result in visual loss as a result of chemical or mechanical manipulation (e.g. laser-induced trauma) http://purl.obolibrary.org/obo/MP_0011558 abnormal urine insulin level http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis any change in the amount of insulin in the urine http://purl.obolibrary.org/obo/MP_0011559 increased urine insulin level http://purl.obolibrary.org/obo/MP_0011558 abnormal urine insulin level a greater amount of insulin in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0011560 decreased urine insulin level http://purl.obolibrary.org/obo/MP_0011558 abnormal urine insulin level a reduced amount of insulin in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0011561 renal glomerulus lipidosis http://purl.obolibrary.org/obo/MP_0005325 abnormal renal glomerulus morphology presence of lipid deposits and/or lipid-laden foam cells in the renal glomerular tufts http://purl.obolibrary.org/obo/MP_0011562 abnormal urine prostaglandin level http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis any change in the urinary amount of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation http://purl.obolibrary.org/obo/MP_0011563 increased urine prostaglandin level http://purl.obolibrary.org/obo/MP_0011562 abnormal urine prostaglandin level a greater amount of any prostaglandin in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0011564 decreased urine prostaglandin level http://purl.obolibrary.org/obo/MP_0011562 abnormal urine prostaglandin level a reduced amount of any prostaglandin in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0011565 kidney papillary hypoplasia http://purl.obolibrary.org/obo/MP_0004193 abnormal kidney papilla morphology underdevelopment or reduced size, usually due to a reduced number of cells, of the apex of the renal pyramid that normally projects into a calyx http://purl.obolibrary.org/obo/MP_0011567 increased renal glomerulus lobularity http://purl.obolibrary.org/obo/MP_0005325 abnormal renal glomerulus morphology distortion of the renal glomerular architecture usually accompanied by increased mesangial cell proliferation and following crowding of the proliferated cells towards the axis of the capillary loops and peripheral recanalization, giving the glomerular tuft a lobular or hypersegmented appearance http://purl.obolibrary.org/obo/MP_0011568 decreased foot pigmentation http://purl.obolibrary.org/obo/MP_0005408 hypopigmentation visually detectable dilution of pigment present on the foot surface http://purl.obolibrary.org/obo/MP_0011569 abnormal azygos vein morphology http://purl.obolibrary.org/obo/MP_0002725 abnormal vein morphology any structural anomaly of the unpaired vein which in humans arises from the right ascending lumbar vein or the vena cava, enters the thorax through the aortic orifice in the diaphragm, and terminates in the superior vena cava; unlike humans, mice have a single and left-sided azygos vein that develops from the paired embryonic cardinal venous system and drains most of the right and left thoracic walls into the left anterior vena cava http://purl.obolibrary.org/obo/MP_0011570 esophageal achalasia http://purl.obolibrary.org/obo/MP_0010154 abnormal gastroesophageal sphincter physiology failure of the normal relaxation of the lower esophageal sphincter associated with the uncoordinated contractions of the thoracic esophagus, resulting in functional obstruction http://purl.obolibrary.org/obo/MP_0011571 enlarged inferior vena cava valve http://purl.obolibrary.org/obo/MP_0010490 abnormal inferior vena cava valve morphology increased size of the semicircular fold of endocardium located on the right atrium at the point of attachment of the inferior vena cava http://purl.obolibrary.org/obo/MP_0011573 abnormal sinotubular junction morphology http://purl.obolibrary.org/obo/MP_0009867 abnormal ascending aorta morphology any structural anomaly of the point in the ascending aorta where the aortic sinuses end and the aorta becomes a tubular structure http://purl.obolibrary.org/obo/MP_0011574 dilated sinotubular junction http://purl.obolibrary.org/obo/MP_0011573 abnormal sinotubular junction morphology the luminal space of the sinotubular junction is increased in diameter or area http://purl.obolibrary.org/obo/MP_0011575 dilated aorta bulb http://purl.obolibrary.org/obo/MP_0011572 abnormal aorta bulb morphology the luminal space of the aorta bulb is increased in volume or area, usually with an increase of contained fluid http://purl.obolibrary.org/obo/MP_0011576 absent cervical atlas http://purl.obolibrary.org/obo/MP_0004607 abnormal cervical atlas morphology absence of the first (topmost, C1) cervical vertebra which supports the globe of the head http://purl.obolibrary.org/obo/MP_0011577 abnormal lipoprotein lipase activity http://purl.obolibrary.org/obo/MP_0011580 abnormal triglyceride lipase activity anomaly in the ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate http://purl.obolibrary.org/obo/MP_0011578 increased lipoprotein lipase activity http://purl.obolibrary.org/obo/MP_0011581 increased triglyceride lipase activity greater ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate http://purl.obolibrary.org/obo/MP_0011579 decreased lipoprotein lipase activity http://purl.obolibrary.org/obo/MP_0011582 decreased triglyceride lipase activity reduced ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate http://purl.obolibrary.org/obo/MP_0011580 abnormal triglyceride lipase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion http://purl.obolibrary.org/obo/MP_0011581 increased triglyceride lipase activity http://purl.obolibrary.org/obo/MP_0011580 abnormal triglyceride lipase activity greater ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion http://purl.obolibrary.org/obo/MP_0011582 decreased triglyceride lipase activity http://purl.obolibrary.org/obo/MP_0011580 abnormal triglyceride lipase activity reduced ability to catalyze the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion http://purl.obolibrary.org/obo/MP_0011583 abnormal alkaline phosphatase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum http://purl.obolibrary.org/obo/MP_0011584 increased alkaline phosphatase activity http://purl.obolibrary.org/obo/MP_0011583 abnormal alkaline phosphatase activity greater ability to catalyze the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum http://purl.obolibrary.org/obo/MP_0011585 decreased alkaline phosphatase activity http://purl.obolibrary.org/obo/MP_0011583 abnormal alkaline phosphatase activity reduced ability to catalyze the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum http://purl.obolibrary.org/obo/MP_0011586 abnormal ornithine carbamoyltransferase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline http://purl.obolibrary.org/obo/MP_0011587 increased ornithine carbamoyltransferase activity http://purl.obolibrary.org/obo/MP_0011586 abnormal ornithine carbamoyltransferase activity greater ability to catalyze the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline http://purl.obolibrary.org/obo/MP_0011588 decreased ornithine carbamoyltransferase activity http://purl.obolibrary.org/obo/MP_0011586 abnormal ornithine carbamoyltransferase activity reduced ability to catalyze the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline http://purl.obolibrary.org/obo/MP_0011589 abnormal hormone-sensitive lipase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate http://purl.obolibrary.org/obo/MP_0011590 increased hormone-sensitive lipase activity http://purl.obolibrary.org/obo/MP_0011589 abnormal hormone-sensitive lipase activity greater ability to catalyze the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate http://purl.obolibrary.org/obo/MP_0011591 decreased hormone-sensitive lipase activity http://purl.obolibrary.org/obo/MP_0011589 abnormal hormone-sensitive lipase activity reduced ability to catalyze the reactions: diacylglycerol + H2O = monoacylglycerol + a carboxylate; triacylglycerol + H2O = diacylglycerol + a carboxylate; and monoacylglycerol + H2O = glycerol + a carboxylate http://purl.obolibrary.org/obo/MP_0011592 abnormal catalase activity http://purl.obolibrary.org/obo/MP_0012579 abnormal peroxidase activity anomaly in the ability to catalyze the reaction: 2 hydrogen peroxide = O2 + 2 H2O http://purl.obolibrary.org/obo/MP_0011593 increased catalase activity http://purl.obolibrary.org/obo/MP_0012582 increased peroxidase activity greater ability to catalyze the reaction: 2 hydrogen peroxide = O2 + 2 H2O http://purl.obolibrary.org/obo/MP_0011594 decreased catalase activity http://purl.obolibrary.org/obo/MP_0012580 decreased peroxidase activity reduced ability to catalyze the reaction: 2 hydrogen peroxide = O2 + 2 H2O http://purl.obolibrary.org/obo/MP_0011595 abnormal purine-nucleoside phosphorylase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate http://purl.obolibrary.org/obo/MP_0011596 increased purine-nucleoside phosphorylase activity http://purl.obolibrary.org/obo/MP_0011595 abnormal purine-nucleoside phosphorylase activity greater ability to catalyze the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate http://purl.obolibrary.org/obo/MP_0011597 decreased purine-nucleoside phosphorylase activity http://purl.obolibrary.org/obo/MP_0011595 abnormal purine-nucleoside phosphorylase activity reduced ability to catalyze the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate http://purl.obolibrary.org/obo/MP_0011598 abnormal phosphatidylcholine-sterol O-acyltransferase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine http://purl.obolibrary.org/obo/MP_0011599 increased phosphatidylcholine-sterol O-acyltransferase activity http://purl.obolibrary.org/obo/MP_0011598 abnormal phosphatidylcholine-sterol O-acyltransferase activity greater ability to catalyze the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine http://purl.obolibrary.org/obo/MP_0011600 decreased phosphatidylcholine-sterol O-acyltransferase activity http://purl.obolibrary.org/obo/MP_0011598 abnormal phosphatidylcholine-sterol O-acyltransferase activity reduced ability to catalyze the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine http://purl.obolibrary.org/obo/MP_0011601 abnormal glutathione peroxidase activity http://purl.obolibrary.org/obo/MP_0012579 abnormal peroxidase activity anomaly in the ability to catalyze the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O http://purl.obolibrary.org/obo/MP_0011602 increased glutathione peroxidase activity http://purl.obolibrary.org/obo/MP_0012582 increased peroxidase activity greater ability to catalyze the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O http://purl.obolibrary.org/obo/MP_0011603 decreased glutathione peroxidase activity http://purl.obolibrary.org/obo/MP_0012580 decreased peroxidase activity reduced ability to catalyze the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O http://purl.obolibrary.org/obo/MP_0011604 abnormal glucokinase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate http://purl.obolibrary.org/obo/MP_0011605 increased glucokinase activity http://purl.obolibrary.org/obo/MP_0011604 abnormal glucokinase activity greater ability to catalyze the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate http://purl.obolibrary.org/obo/MP_0011606 decreased glucokinase activity http://purl.obolibrary.org/obo/MP_0011604 abnormal glucokinase activity reduced ability to catalyze the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate http://purl.obolibrary.org/obo/MP_0011607 abnormal glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+ http://purl.obolibrary.org/obo/MP_0011608 increased glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity http://purl.obolibrary.org/obo/MP_0011607 abnormal glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity greater ability to catalyze the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+ http://purl.obolibrary.org/obo/MP_0011609 decreased glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity http://purl.obolibrary.org/obo/MP_0011607 abnormal glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity reduced ability to catalyze the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+ http://purl.obolibrary.org/obo/MP_0011610 abnormal primordial germ cell apoptosis http://purl.obolibrary.org/obo/MP_0001919 abnormal reproductive system physiology change in the timing or the number of primordial germ cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0011611 abnormal circulating ghrelin level http://purl.obolibrary.org/obo/MP_0005418 abnormal circulating hormone level any anomaly in the blood concentration of the peptide hormone produced mainly by P/D1 cells lining the fundus of the stomach and epsilon cells of the pancreas that stimulates hunger and serves as a potent stimulator of growth hormone from the anterior pituitary gland; in addition to stimulating appetite and growth, ghrelin also plays various roles in energy homeostasis, neuropathy, and in the cardiovascular and immune systems http://purl.obolibrary.org/obo/MP_0011612 increased circulating ghrelin level http://purl.obolibrary.org/obo/MP_0011611 abnormal circulating ghrelin level greater than the normal blood concentration of the peptide hormone produced mainly by P/D1 cells lining the fundus of the stomach and epsilon cells of the pancreas that normally stimulates hunger and serves as a potent stimulator of growth hormone from the anterior pituitary gland http://purl.obolibrary.org/obo/MP_0011613 decreased circulating ghrelin level http://purl.obolibrary.org/obo/MP_0011611 abnormal circulating ghrelin level less than the normal blood concentration of the peptide hormone produced mainly by P/D1 cells lining the fundus of the stomach and epsilon cells of the pancreas that normally stimulates hunger and serves as a potent stimulator of growth hormone from the anterior pituitary gland http://purl.obolibrary.org/obo/MP_0011614 slow aging http://purl.obolibrary.org/obo/MP_0010768 mortality/aging later than normal occurrence of the normal signs of aging http://purl.obolibrary.org/obo/MP_0011615 submucous cleft palate http://purl.obolibrary.org/obo/MP_0009890 cleft secondary palate a cleft of the soft palate with cardinal signs including a bifid uvula, a V-shaped notch at the back of the hard palate, a translucent line in the midline of the soft palate and a short palate http://purl.obolibrary.org/obo/MP_0011616 abnormal nonassociative learning http://purl.obolibrary.org/obo/MP_0002063 abnormal learning/memory/conditioning anomaly in the process of a simple form of learning whereby the repeated presence of a stimulus leads to a change in the probability or strength of the response to that stimulus; there is no association of one type of stimulus with another, rather it is a generalized response to the environment http://purl.obolibrary.org/obo/MP_0011617 abnormal habituation http://purl.obolibrary.org/obo/MP_0011616 abnormal nonassociative learning anomaly in the process in which there is a progressive decline of behavioral response probability with a repetitive stimulus http://purl.obolibrary.org/obo/MP_0011618 abnormal sensitization http://purl.obolibrary.org/obo/MP_0011616 abnormal nonassociative learning anomaly in the process in which a progressive amplification of a behavioral response follows repeated administration of a stimulus http://purl.obolibrary.org/obo/MP_0011619 abnormal dishabituation http://purl.obolibrary.org/obo/MP_0011616 abnormal nonassociative learning anomaly in the process in which there is a temporary recovery of response to a stimulus when a novel stimulus is added http://purl.obolibrary.org/obo/MP_0011620 abnormal habituation to a new environment http://purl.obolibrary.org/obo/MP_0011617 abnormal habituation anomaly in the process in which there is a progressive decline of behavioral response probability with an exposure to a new environment http://purl.obolibrary.org/obo/MP_0011621 abnormal habituation to a novel object http://purl.obolibrary.org/obo/MP_0011617 abnormal habituation anomaly in the process in which there is a progressive decline of behavioral response probability with an exposure to a novel object http://purl.obolibrary.org/obo/MP_0011622 abnormal habituation to a novel odor http://purl.obolibrary.org/obo/MP_0011617 abnormal habituation anomaly in the process in which there is a progressive decline of behavioral response probability with an exposure to a novel odor http://purl.obolibrary.org/obo/MP_0011623 abnormal habituation to xenobiotic http://purl.obolibrary.org/obo/MP_0011617 abnormal habituation anomaly in the process in which there is a progressive decline of behavioral response probability with exposure to xenobiotics http://purl.obolibrary.org/obo/MP_0011624 abnormal sensitization to xenobiotic http://purl.obolibrary.org/obo/MP_0011618 abnormal sensitization anomaly in the process in which a progressive amplification of a behavioral response follows repeated administration of a xenobiotic http://purl.obolibrary.org/obo/MP_0011625 cystolithiasis http://purl.obolibrary.org/obo/MP_0005360 urolithiasis caliculi, or a solid concretion or crystal aggregation, found in the urinary bladder; often embedded in a glycoprotein matrix which may also contain some nonglycoproteins when associated with infection http://purl.obolibrary.org/obo/MP_0011626 orotic acid urinary bladder stones http://purl.obolibrary.org/obo/MP_0011625 cystolithiasis presence of caliculi, or a solid concretion or crystal aggregation formed from orotic acid, found in the urinary bladder; often embedded in a glycoprotein matrix which may also contain some nonglycoproteins when associated with infection http://purl.obolibrary.org/obo/MP_0011627 decreased skin pigmentation http://purl.obolibrary.org/obo/MP_0005408 hypopigmentation visually detectable dilution of pigment present in the skin http://purl.obolibrary.org/obo/MP_0011628 increased mitochondria number http://purl.obolibrary.org/obo/MP_0006035 abnormal mitochondrion morphology greater than normal number of the cellular organelles responsible for energy production http://purl.obolibrary.org/obo/MP_0011629 decreased mitochondria number http://purl.obolibrary.org/obo/MP_0006035 abnormal mitochondrion morphology fewer than normal number of the cellular organelles responsible for energy production http://purl.obolibrary.org/obo/MP_0011630 increased mitochondria size http://purl.obolibrary.org/obo/MP_0006035 abnormal mitochondrion morphology enlarged the cellular organelles responsible for energy production http://purl.obolibrary.org/obo/MP_0011631 decreased mitochondria size http://purl.obolibrary.org/obo/MP_0006035 abnormal mitochondrion morphology reduced size of the cellular organelles responsible for energy production http://purl.obolibrary.org/obo/MP_0011632 dilated mitochondria http://purl.obolibrary.org/obo/MP_0011630 increased mitochondria size the luminal space of the mitochondria is increased in volume or area, usually with an increase of contained fluid http://purl.obolibrary.org/obo/MP_0011633 abnormal mitochondrial shape http://purl.obolibrary.org/obo/MP_0006035 abnormal mitochondrion morphology any anomaly in the characteristic surface outline or contour of a mitochondria http://purl.obolibrary.org/obo/MP_0011634 abnormal mitochondrial inner membrane morphology http://purl.obolibrary.org/obo/MP_0006035 abnormal mitochondrion morphology any structural anomaly of the inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope, which is highly folded to form cristae http://purl.obolibrary.org/obo/MP_0011635 abnormal mitochondrial crista morphology http://purl.obolibrary.org/obo/MP_0011634 abnormal mitochondrial inner membrane morphology Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria http://purl.obolibrary.org/obo/MP_0011636 disorganized mitochondrial cristae http://purl.obolibrary.org/obo/MP_0011635 abnormal mitochondrial crista morphology derangement of the pattern of the inward folds of the mitochondrial inner membrane http://purl.obolibrary.org/obo/MP_0011637 abnormal mitochondrial matrix morphology http://purl.obolibrary.org/obo/MP_0006035 abnormal mitochondrion morphology any structural anomaly of the gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion, and contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation http://purl.obolibrary.org/obo/MP_0011638 abnormal mitochondrial chromosome morphology http://purl.obolibrary.org/obo/MP_0006035 abnormal mitochondrion morphology any structrual anomaly of the chromosome found in the mitochondrion of a eukaryotic cell http://purl.obolibrary.org/obo/MP_0011639 decreased mitochondrial DNA content http://purl.obolibrary.org/obo/MP_0011638 abnormal mitochondrial chromosome morphology less than expected amount of DNA contained within the mirochondria of a eukaryotic cell http://purl.obolibrary.org/obo/MP_0011640 abnormal aorta collagen fibril morphology http://purl.obolibrary.org/obo/MP_0009871 abnormal aorta tunica adventitia morphology any structural anomaly of the connective tissue bundles in the extracellular matrix of aorta tissue that are composed of collagen, and play a role in tissue strength and elasticity http://purl.obolibrary.org/obo/MP_0011641 abnormal pulmonary collagen fibril morphology http://purl.obolibrary.org/obo/MP_0001175 abnormal lung morphology any structural anomaly of the connective tissue bundles in the extracellular matrix of pulmonary tissue that are composed of collagen, and play a role in tissue strength and elasticity http://purl.obolibrary.org/obo/MP_0011642 abnormal bone collagen fibril morphology http://purl.obolibrary.org/obo/MP_0003795 abnormal bone structure any structural anomaly of the connective tissue bundles in the extracellular matrix of bone tissue that are composed of collagen, and play a role in tissue strength and elasticity http://purl.obolibrary.org/obo/MP_0011643 abnormal tendon collagen fibril morphology http://purl.obolibrary.org/obo/MP_0005503 abnormal tendon morphology any structural anomaly of the connective tissue bundles in the extracellular matrix of tendon tissue that are composed of collagen, and play a role in tissue strength and elasticity http://purl.obolibrary.org/obo/MP_0011644 abnormal oviduct epithelium motile cilium morphology http://purl.obolibrary.org/obo/MP_0013206 abnormal motile cilium morphology any structural anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the oviduct http://purl.obolibrary.org/obo/MP_0011645 absent oviduct epithelium motile cilium http://purl.obolibrary.org/obo/MP_0011644 abnormal oviduct epithelium motile cilium morphology absence of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the oviduct http://purl.obolibrary.org/obo/MP_0011646 abnormal sinuatrial valve morphology http://purl.obolibrary.org/obo/MP_0000267 abnormal heart development any structural anomaly of the valve at the sinuatrial orifice at the opening of the sinus venosus into the primordial right atrium http://purl.obolibrary.org/obo/MP_0011647 absent sinuatrial valve http://purl.obolibrary.org/obo/MP_0011646 abnormal sinuatrial valve morphology absence of the valve at the sinuatrial orifice at the opening of the sinus venosus into the primordial right atrium http://purl.obolibrary.org/obo/MP_0011649 immotile respiratory cilia http://purl.obolibrary.org/obo/MP_0011055 abnormal respiratory motile cilium physiology failure of the multiple epithelial tiny, motile hair-like projections of the repiratory tract epithelium to beat with a characteristic whip-like pattern in order to promote transport of fluids and other cells across the epithelium of the respiratory tract http://purl.obolibrary.org/obo/MP_0011650 abnormal corneal stroma collagen fibril morphology http://purl.obolibrary.org/obo/MP_0005300 abnormal corneal stroma morphology any structural anomaly of the connective tissue bundles in the extracellular matrix of corneal stroma that are composed of collagen, and play a role in tissue strength and elasticity http://purl.obolibrary.org/obo/MP_0011651 abnormal circulating histidine level http://purl.obolibrary.org/obo/MP_0005311 abnormal circulating amino acid level the amount of the amino acid histidine in the blood is more or less than expected http://purl.obolibrary.org/obo/MP_0011652 increased circulating histidine level http://purl.obolibrary.org/obo/MP_0011651 abnormal circulating histidine level the amount of the amino acid histidine in the blood is more than expected http://purl.obolibrary.org/obo/MP_0011653 decreased circulating histidine level http://purl.obolibrary.org/obo/MP_0011651 abnormal circulating histidine level the amount of the amino acid histidine in the blood is less than expected http://purl.obolibrary.org/obo/MP_0011654 increased urine histidine level http://purl.obolibrary.org/obo/MP_0003311 aminoaciduria increased excretion of histidine and related imidazole metabolites in urine http://purl.obolibrary.org/obo/MP_0011656 coronary arterio-venous fistula http://purl.obolibrary.org/obo/MP_0010476 coronary fistula an abnormal communication between the terminus of a coronary artery, bypassing the myocardial capillary bed and entering any segment of the systemic or pulmonary circulation http://purl.obolibrary.org/obo/MP_0011657 coronary-cameral fistula http://purl.obolibrary.org/obo/MP_0010476 coronary fistula an abnormal communication between the terminus of a coronary artery, bypassing the myocardial capillary bed and entering a chamber of the heart (coronary-cameral fistula) http://purl.obolibrary.org/obo/MP_0011658 interrupted aortic arch, type a http://purl.obolibrary.org/obo/MP_0004157 interrupted aortic arch complete discontinuation/blockage between the ascending and descending aorta with the interruption located distal to the subclavian artery that is ipsilateral to the second carotid artery http://purl.obolibrary.org/obo/MP_0011659 interrupted aortic arch, type b http://purl.obolibrary.org/obo/MP_0004157 interrupted aortic arch complete discontinuation/blockage between the ascending and descending aorta with the interruption located between second carotid artery and ipsilateral subclavian artery http://purl.obolibrary.org/obo/MP_0011660 ectopia cordis http://purl.obolibrary.org/obo/MP_0006065 abnormal heart position or orientation congenital condition in which the heart is exposed and/or protruding from the thorax due to abnormal development of the sternum, pericardium and/or the abdominal wall http://purl.obolibrary.org/obo/MP_0011661 persistent truncus arteriosus type i http://purl.obolibrary.org/obo/MP_0002633 persistent truncus arteriosis complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development; type i is characterized by origin of a single pulmonary trunk from the left lateral aspect of the common trunk, with branching of the left and right pulmonary arteries from the pulmonary trunk http://purl.obolibrary.org/obo/MP_0011662 persistent truncus arteriosus type ii http://purl.obolibrary.org/obo/MP_0002633 persistent truncus arteriosis complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development; type II is characterized by separate but proximate origins of the left and right pulmonary arterial branches from the posterolateral aspect of the common arterial trunk http://purl.obolibrary.org/obo/MP_0011663 persistent truncus arteriosus type iii http://purl.obolibrary.org/obo/MP_0002633 persistent truncus arteriosis complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development; in type iii the branch pulmonary arteries originate independently from the common arterial trunk or aortic arch, most often from the left and right lateral aspects of the trunk; this occasionally occurs with origin of one pulmonary artery from the underside of the aortic arch, usually from a ductus arteriosus http://purl.obolibrary.org/obo/MP_0011664 persistent truncus arteriosus type iv http://purl.obolibrary.org/obo/MP_0002633 persistent truncus arteriosis complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development; type i is a form of the lesion with neither pulmonary arterial branch arises from the common trunk, and is more commonly recognized to be a form of pulmonary atresia with ventricular septal defect rather than truncus arteriosus http://purl.obolibrary.org/obo/MP_0011665 d-loop transposition of the great arteries http://purl.obolibrary.org/obo/MP_0004110 transposition of great arteries complete transposition of the great arteries; the d- refers to the dextroposition of the bulboventricular loop (ie, the position of the right ventricle, which is on the right side); in addition, the aorta also tends to be on the right and anterior, and the great arteries are parallel rather than crossing http://purl.obolibrary.org/obo/MP_0011666 double outlet right ventricle, ventricular defect committed to aorta http://purl.obolibrary.org/obo/MP_0000284 double outlet right ventricle a form of DORV in which a ventricular septal defect is located just below the aorta; the left ventricular outflow is directed toward the aorta, resulting in aortic oxygen saturations that exceed pulmonary saturations; pulmonary stenosis is also often present http://purl.obolibrary.org/obo/MP_0011667 double outlet right ventricle with atrioventricular septal defect http://purl.obolibrary.org/obo/MP_0000284 double outlet right ventricle a form of DORV in which there is also a complete atrioventricular canal http://purl.obolibrary.org/obo/MP_0011668 double outlet right ventricle, Taussig bing type http://purl.obolibrary.org/obo/MP_0000284 double outlet right ventricle a form of DORV in which blood from the left ventricle passes through a ventricular septal defect to the pulmonary artery, and blood from the right ventricle is directed to the aorta http://purl.obolibrary.org/obo/MP_0011669 double outlet right ventricle, doubly committed ventricular septal defect http://purl.obolibrary.org/obo/MP_0000284 double outlet right ventricle a form of DORV in which there are two ventricular septal defects, one below the aorta and one below the pulmonary artery and the left ventricular outflow is equally shared by the aorta and pulmonary artery http://purl.obolibrary.org/obo/MP_0011670 double outlet right ventricle, noncommitted ventricular septal defect http://purl.obolibrary.org/obo/MP_0000284 double outlet right ventricle a form of DORV in which the ventricular septal defect is distant from both the aorta and pulmonary artery and blood mixes in the right ventricle before entering these vessels, with the majority of deoxygenated blood entering the aorta http://purl.obolibrary.org/obo/MP_0011675 double aortic arch, balanced arches http://purl.obolibrary.org/obo/MP_0004159 double aortic arch defect in which the aortic arch splits into equally sized large left and right branches, encircling the trachea and esophagus, before becoming one tube to go to the lower body http://purl.obolibrary.org/obo/MP_0011676 aortic arch obstruction http://purl.obolibrary.org/obo/MP_0004113 abnormal aortic arch morphology any impediment or blockage causing a cessation or reversal of the normal flow of the blood through the aortic arch http://purl.obolibrary.org/obo/MP_0011677 abnormal olfactory sensory neuron physiology http://purl.obolibrary.org/obo/MP_0010055 abnormal sensory neuron physiology any functional anomaly of cells that innervate the olfactory epithelium and are responsible for receiving and transmitting odorant signals http://purl.obolibrary.org/obo/MP_0011678 abnormal vomeronasal sensory neuron physiology http://purl.obolibrary.org/obo/MP_0010055 abnormal sensory neuron physiology any functional anomaly of chemosensitive cells that innervate the vomernasal organ epithelium and are responsible for receiving and transmitting pheromone signals http://purl.obolibrary.org/obo/MP_0011679 abnormal vomeronasal sensory neuron morphology http://purl.obolibrary.org/obo/MP_0001001 abnormal chemoreceptor morphology any structural anomaly of chemosensitive cells that innervate the vomernasal organ epithelium and are responsible for receiving and transmitting pheromone signals http://purl.obolibrary.org/obo/MP_0011680 tricuspid valve hypoplasia http://purl.obolibrary.org/obo/MP_0002624 abnormal tricuspid valve morphology decrease in the number of normal cells in normal arrangement in the tricuspid valve, resulting in a decreased size caused by underdevelopment or incomplete development of the structure http://purl.obolibrary.org/obo/MP_0011681 atrium cysts http://purl.obolibrary.org/obo/MP_0003105 abnormal heart atrium morphology abnormal membranous sacs in any portion of the paired upper chambers of the heart http://purl.obolibrary.org/obo/MP_0011682 renal glomerulus cysts http://purl.obolibrary.org/obo/MP_0003675 kidney cysts abnormal membranous sacs in any portion of the renal glomerulus http://purl.obolibrary.org/obo/MP_0011683 dual inferior vena cava http://purl.obolibrary.org/obo/MP_0006063 abnormal inferior vena cava morphology presence of two inferior vena cavae, often resulting from the persistence of both supracardinal veins during development; the two structures may be symmetric or asymmetric but typically join together at the renal vein http://purl.obolibrary.org/obo/MP_0011684 coronary-cameral fistula to right ventricle http://purl.obolibrary.org/obo/MP_0011657 coronary-cameral fistula an abnormal communication between the terminus of a coronary artery, bypassing the myocardial capillary bed and entering the right ventricle http://purl.obolibrary.org/obo/MP_0011685 abnormal limb paddle morphology http://purl.obolibrary.org/obo/MP_0006279 abnormal limb development any structural anomaly of the transient developing limb structure that develops from the limb bud; it is a dorsoventral flattening of the limb bud structure and develops into the foot plate http://purl.obolibrary.org/obo/MP_0011686 increased epidermal stem cell number http://purl.obolibrary.org/obo/MP_0011004 abnormal epidermal stem cell morphology greater than expected number of somatic stem cells that are part of the epidermis http://purl.obolibrary.org/obo/MP_0011687 decreased epidermal stem cell number http://purl.obolibrary.org/obo/MP_0011004 abnormal epidermal stem cell morphology a reduction in the number of somatic stem cells that are part of the epidermis http://purl.obolibrary.org/obo/MP_0011688 absent epidermal stem cells http://purl.obolibrary.org/obo/MP_0011687 decreased epidermal stem cell number absence of the somatic stem cells that are part of the epidermis http://purl.obolibrary.org/obo/MP_0011689 absent neutrophils http://purl.obolibrary.org/obo/MP_0000222 decreased neutrophil cell number absence of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes http://purl.obolibrary.org/obo/MP_0011690 absent basophils http://purl.obolibrary.org/obo/MP_0002607 decreased basophil cell number absence of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size; these cells contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation http://purl.obolibrary.org/obo/MP_0011691 absent bronchioalveolar stem cells http://purl.obolibrary.org/obo/MP_0010830 decreased bronchioalveolar stem cell number absence of the respiratory stem cells found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole, which gives rise to alveolar cell types and Clara cells in response to lung injury http://purl.obolibrary.org/obo/MP_0011692 increased chondrocyte number http://purl.obolibrary.org/obo/MP_0000166 abnormal chondrocyte morphology greater number of polymorphic cells that form cartilage http://purl.obolibrary.org/obo/MP_0011693 absent chondrocytes http://purl.obolibrary.org/obo/MP_0000167 decreased chondrocyte number absence of polymorphic cells that form cartilage http://purl.obolibrary.org/obo/MP_0011694 absent eosinophils http://purl.obolibrary.org/obo/MP_0005012 decreased eosinophil cell number any structural anomaly of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin http://purl.obolibrary.org/obo/MP_0011695 absent hematopoietic stem cells http://purl.obolibrary.org/obo/MP_0004810 decreased hematopoietic stem cell number absence of the multipotent, self-renewing stem cells found in the bone marrow, yolk sac and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages http://purl.obolibrary.org/obo/MP_0011696 absent mast cells http://purl.obolibrary.org/obo/MP_0000336 decreased mast cell number any structural anomaly of a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation; progenitors leave bone marrow and mature in connective and mucosal tissue; mature mast cells are found in all tissues, except the bloodstream. http://purl.obolibrary.org/obo/MP_0011697 vacuolated lens http://purl.obolibrary.org/obo/MP_0005545 abnormal lens development fluid filled cavities are present in the cytoplasm of the transparent structure of the eye responsible for focusing light http://purl.obolibrary.org/obo/MP_0011698 abnormal brown adipose tissue physiology http://purl.obolibrary.org/obo/MP_0005666 abnormal adipose tissue physiology any functional anomaly in the thermogenic form of adipose tissue that is composed of brown adipocytes http://purl.obolibrary.org/obo/MP_0011699 abnormal brown adipose tissue thermogenesis http://purl.obolibrary.org/obo/MP_0011698 abnormal brown adipose tissue physiology any anomaly in the process of heat production in brown adipocytes http://purl.obolibrary.org/obo/MP_0011700 increased cumulus expansion http://purl.obolibrary.org/obo/MP_0009373 abnormal cumulus expansion greater ability of the ovarian cumulus cells to secrete an extensive extracellular matrix required for successful fertilization http://purl.obolibrary.org/obo/MP_0011701 decreased cumulus expansion http://purl.obolibrary.org/obo/MP_0009373 abnormal cumulus expansion reduced ability of the ovarian cumulus cells to secrete an extensive extracellular matrix required for successful fertilization http://purl.obolibrary.org/obo/MP_0011702 abnormal fibroblast proliferation http://purl.obolibrary.org/obo/MP_0000350 abnormal cell proliferation anomaly in the ability of the a fibroblast cell population to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0011703 increased fibroblast proliferation http://purl.obolibrary.org/obo/MP_0011702 abnormal fibroblast proliferation greater the expansion rate of a fibroblast cell population by cell division http://purl.obolibrary.org/obo/MP_0011704 decreased fibroblast proliferation http://purl.obolibrary.org/obo/MP_0011702 abnormal fibroblast proliferation reduction in the expansion rate of a fibroblast cell population by cell division http://purl.obolibrary.org/obo/MP_0011705 absent fibroblast proliferation http://purl.obolibrary.org/obo/MP_0011704 decreased fibroblast proliferation failure of a fibroblast cell population to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0011706 abnormal fibroblast migration http://purl.obolibrary.org/obo/MP_0003091 abnormal cell migration any anomaly of cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium http://purl.obolibrary.org/obo/MP_0011707 impaired fibroblast cell migration http://purl.obolibrary.org/obo/MP_0011708 decreased fibroblast cell migration failure of cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium http://purl.obolibrary.org/obo/MP_0011708 decreased fibroblast cell migration http://purl.obolibrary.org/obo/MP_0011706 abnormal fibroblast migration reduced frequency of or less rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium http://purl.obolibrary.org/obo/MP_0011709 increased fibroblast cell migration http://purl.obolibrary.org/obo/MP_0011706 abnormal fibroblast migration greater frequency of or more rapid cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium http://purl.obolibrary.org/obo/MP_0011710 enhanced osteoblast differentiation http://purl.obolibrary.org/obo/MP_0008395 abnormal osteoblast differentiation increased ability or increased rate of production of skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell http://purl.obolibrary.org/obo/MP_0011711 impaired osteoblast differentiation http://purl.obolibrary.org/obo/MP_0008395 abnormal osteoblast differentiation reduced ability or inability to produce skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell http://purl.obolibrary.org/obo/MP_0011712 arrested osteoblast differentiation http://purl.obolibrary.org/obo/MP_0011711 impaired osteoblast differentiation inability to produce skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell, due to a block in the process to create a mature osteoblast http://purl.obolibrary.org/obo/MP_0011720 abnormal ossification involved in bone remodeling http://purl.obolibrary.org/obo/MP_0008271 abnormal bone ossification any anomaly in the formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli http://purl.obolibrary.org/obo/MP_0011721 abnormal bone mineralization involved in bone maturation http://purl.obolibrary.org/obo/MP_0011722 abnormal ossification involved in bone maturation anomaly in the deposition of calcium phosphate in bone tissue, involved in the progression of the developing skeleton from its formation to its mature state http://purl.obolibrary.org/obo/MP_0011722 abnormal ossification involved in bone maturation http://purl.obolibrary.org/obo/MP_0008271 abnormal bone ossification anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the developing skeleton from its formation to its mature state http://purl.obolibrary.org/obo/MP_0011724 ectopic cortical neuron http://purl.obolibrary.org/obo/MP_0011723 ectopic neuron appearance of a cerebral cortical neuron or group of cerebral cortical neurons in a region where it is not normally found http://purl.obolibrary.org/obo/MP_0011725 neuronal leptomeningeal ectopia http://purl.obolibrary.org/obo/MP_0011723 ectopic neuron during development, migrating cortical neurons fail to stop at the border of the marginal zone and continue through this layer and occasionally through the pial-glial layer into the meninges http://purl.obolibrary.org/obo/MP_0011726 ectopic Cajal-Retzius cell http://purl.obolibrary.org/obo/MP_0008030 abnormal Cajal-Retzius cell morphology appearance of a Cajal-Retzius cell in a region where it is not normally found http://purl.obolibrary.org/obo/MP_0011727 ectopic ovary http://purl.obolibrary.org/obo/MP_0001126 abnormal ovary morphology one or both of the ovaries located outside the normal pathway of descent from the lumbar region to a shallow depression on the lateral wall of the pelvis known as the ovarian fossa; the fossa usually lies beneath the external iliac artery and in front of the ureter and the internal iliac artery; ovarian maldescent may be associated with Mullerian malformations http://purl.obolibrary.org/obo/MP_0011728 abnormal pineal gland physiology http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology any functional anomaly of the small flattened endocrine gland located in the depression between the superior colliculi of the brain http://purl.obolibrary.org/obo/MP_0011729 abnormal pineal gland melatonin secretion http://purl.obolibrary.org/obo/MP_0011728 abnormal pineal gland physiology anomaly in the production and/or release of a catecholamine hormone by the pineal body that controls behavior influenced by seasonal changes http://purl.obolibrary.org/obo/MP_0011730 increased myelin sheath thickness http://purl.obolibrary.org/obo/MP_0003871 abnormal myelin sheath morphology increase in the depth of the insulating envelope that surrounds nerve fibers or axons http://purl.obolibrary.org/obo/MP_0011731 decreased myelin sheath thickness http://purl.obolibrary.org/obo/MP_0003871 abnormal myelin sheath morphology decrease in the depth of the insulating envelope that surrounds nerve fibers or axons http://purl.obolibrary.org/obo/MP_0011732 decreased somite size http://purl.obolibrary.org/obo/MP_0005222 abnormal somite size reduced size of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo http://purl.obolibrary.org/obo/MP_0011733 fused somites http://purl.obolibrary.org/obo/MP_0001688 abnormal somite development a defect in which there is an appearance of a single enlarged somite resulting from partial or complete fusion of the two somitic anlage http://purl.obolibrary.org/obo/MP_0011734 abnormal urine ammonia level http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis any change in the amount of ammonia in urine http://purl.obolibrary.org/obo/MP_0011735 increased urine ammonia level http://purl.obolibrary.org/obo/MP_0011734 abnormal urine ammonia level a greater amount of ammonia in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0011736 decreased urine ammonia level http://purl.obolibrary.org/obo/MP_0011734 abnormal urine ammonia level a reduced amount of ammonia in the urine compared to the normal state http://purl.obolibrary.org/obo/MP_0011737 hypodipsia http://purl.obolibrary.org/obo/MP_0001422 abnormal drinking behavior abnormally diminished thirst with a consequential reduction of fluid intake; often related to dysfunction of the thirst osmoreceptor in the anterior hypothalamus http://purl.obolibrary.org/obo/MP_0011738 anasarca http://purl.obolibrary.org/obo/MP_0001785 edema widespread swelling due to effusion of serous fluid into the extracellular space, especially into the connective tissue http://purl.obolibrary.org/obo/MP_0011739 abnormal Boettcher cell morphology http://purl.obolibrary.org/obo/MP_0000031 abnormal cochlea morphology any structural anomaly of the polyhedral cells located on the basilar membrane beneath the Claudius cells in the basal turn of the cochlea, and considered supporting cells for the organ of Corti; Boettcher cells interweave with each other, project microvilli into the intercellular space, show high levels of calmodulin, and may be involved in mediating Ca(2+) regulation and ion transport http://purl.obolibrary.org/obo/MP_0011740 abnormal urine nitrite level http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis anomaly in the amount of nitrite (NO2-) in the urine; may be suggestive of impaired nitric oxide (NO) release, or of a urinary tract infection http://purl.obolibrary.org/obo/MP_0011741 increased urine nitrite level http://purl.obolibrary.org/obo/MP_0011740 abnormal urine nitrite level higher than normal amount of nitrite (NO2-) in the urine, usually indicative of a urinary tract infection; commonly a result of the action of Escherichia coli, Proteus vulgaris, and other microorganisms that may reduce nitrates http://purl.obolibrary.org/obo/MP_0011742 decreased urine nitrite level http://purl.obolibrary.org/obo/MP_0011740 abnormal urine nitrite level lower than normal amount of nitrite (NO2-) in the urine; suggestive of impaired nitric oxide (NO) release http://purl.obolibrary.org/obo/MP_0011743 abnormal Golgi apparatus morphology http://purl.obolibrary.org/obo/MP_0000358 abnormal cell morphology any structural anomaly of the compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack; Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations http://purl.obolibrary.org/obo/MP_0011744 abnormal kidney epithelial cell primary cilium physiology http://purl.obolibrary.org/obo/MP_0013211 abnormal nonmotile primary cilium physiology any functional anomaly of the non-motile primary cilia found on renal epithelial cells and thought to act as a mechanical sensor to detect renal tubular fluid; impaired mechanical response of primary cilia to physiological fluid flow, or abnormalities in intracellular Ca2+ increase in response to fluid stress may alter renal (tubular) cell proliferation and differentiation and lead to renal cyst formation http://purl.obolibrary.org/obo/MP_0011745 isolation of the left subclavian artery http://purl.obolibrary.org/obo/MP_0010488 abnormal left subclavian artery morphology the loss of continuity between the left subclavian artery and the aorta, with persistent connection to the homolateral pulmonary artery through the patent (PDA) or nonpatent ductus arteriosus http://purl.obolibrary.org/obo/MP_0011746 spleen fibrosis http://purl.obolibrary.org/obo/MP_0000689 abnormal spleen morphology invasion of fibrous connective tissue into the spleen, often resulting from inflammation or injury http://purl.obolibrary.org/obo/MP_0011747 myelofibrosis http://purl.obolibrary.org/obo/MP_0002397 abnormal bone marrow morphology appearance of fibrous connective tissue in the bone marrow, often resulting from inflammation or injury; especially replacement of the marrow with collagenous connective tissue fibers, frequently accompanied by splenomegaly and anemia or cytopenias http://purl.obolibrary.org/obo/MP_0011748 intestinal fibrosis http://purl.obolibrary.org/obo/MP_0000477 abnormal intestine morphology formation of fibrous tissue in any part of the intestine as a result of repair or a reactive process http://purl.obolibrary.org/obo/MP_0011749 perivascular fibrosis http://purl.obolibrary.org/obo/MP_0001614 abnormal blood vessel morphology invasion of fibrous connective tissue into the perivascular tissue, often resulting from inflammation or injury http://purl.obolibrary.org/obo/MP_0011751 abnormal X-Y chromosome synapsis during male meiosis http://purl.obolibrary.org/obo/MP_0005169 abnormal male meiosis an anomaly in the process in which the side by side pairing and physical juxtaposition of X and Y chromosomes is created at the metaphase plate, usually resulting in incorrect sex chromosome disjunction http://purl.obolibrary.org/obo/MP_0011752 abnormal X-Y chromosome synaptonemal complex assembly during male meiosis http://purl.obolibrary.org/obo/MP_0005169 abnormal male meiosis an anomaly in the process in which forms the structure that holds the X and Y chomosomes together during prophase I of male meiosis and results in exchange of X and Y chromatin during prophase I, or results in exchange of X and Y chromatin outside the chromatin associated with the pseudoautosomal region http://purl.obolibrary.org/obo/MP_0011753 decreased podocyte number http://purl.obolibrary.org/obo/MP_0005326 abnormal podocyte morphology reduced number of the modified epithelial cells of the visceral layer of the Bowman capsule in the renal corpuscle http://purl.obolibrary.org/obo/MP_0011754 abnormal kidney collecting duct intercalated cell morphology http://purl.obolibrary.org/obo/MP_0011843 abnormal kidney collecting duct epithelium morphology any structural anomaly of any of the functionally distinct subtypes of cells (alpha or beta) found on the kidney collecting duct epithelium that regulate acid-base homeostasis and play an important role in the kidney's response to acidosis and alkalosis; alpha-intercalated cells secrete acid whereas beta-intercalated cells secrete base; metabolic acidosis results in the conversion of beta- cells to alpha-intercalated cells giving the kidney a greater ability to secrete protons and return pH to the normal range http://purl.obolibrary.org/obo/MP_0011755 abnormal kidney collecting duct alpha-intercalated cell morphology http://purl.obolibrary.org/obo/MP_0011754 abnormal kidney collecting duct intercalated cell morphology any structural anomaly of the tall, columnar epithelial cells found on the kidney collecting duct epithelium which secrete acid (via an apical H+-ATPase and H+/K+ exchanger) in the form of hydrogen ions and reabsorb bicarbonate (via band 3, a basolateral Cl-/HCO3- exchanger);damage to the alpha-intercalated cell's ability to secrete acid can result in distal renal tubular acidosis http://purl.obolibrary.org/obo/MP_0011756 abnormal kidney collecting duct beta-intercalated cell morphology http://purl.obolibrary.org/obo/MP_0011754 abnormal kidney collecting duct intercalated cell morphology any structural anomaly of the shorter, flatter cells found on the kidney collecting duct epithelium which secrete bicarbonate (via pendrin, a specialized apical Cl-/HCO3- exchanger) and reabsorb acid (via a basal H+-ATPase) http://purl.obolibrary.org/obo/MP_0011757 abnormal kidney collecting duct principal cell morphology http://purl.obolibrary.org/obo/MP_0011843 abnormal kidney collecting duct epithelium morphology any structural abnormality of the cuboidal epithelial cells found in the collecting ducts of the kidney which regulate sodium and potassium balance via channels located on the cells apical membrane. Aldosterone increases the number of Na+/K+-ATPase pumps that allow increased sodium reabsorption and potassium secretion whereas antidiuretic hormone (vasopressin) determines the expression of aquaporin channels on the cell surface; together, aldosterone and vasopressin let the principal cell control the quantity of water that is reabsorbed http://purl.obolibrary.org/obo/MP_0011758 renal ischemia http://purl.obolibrary.org/obo/MP_0002136 abnormal kidney physiology inadequate blood flow to one or both kidneys, or nephrons, usually due to functional constriction or actual obstruction of a blood vessel; a significant cause of renal dysfunction and cortical and medullary necrosis http://purl.obolibrary.org/obo/MP_0011759 absent Rathke's pouch http://purl.obolibrary.org/obo/MP_0003817 abnormal pituitary diverticulum morphology absence of the diverticulum arsing from the embryonic buccal cavity from which the anterior lobe of the pituitary gland is developed http://purl.obolibrary.org/obo/MP_0011760 abnormal ureteric bud tip morphology http://purl.obolibrary.org/obo/MP_0006032 abnormal ureteric bud morphology any structural anomaly of the terminal ends of the ureteric tree; the ureteric tip cells are proliferating immature cells located at the branching points that induce the adjacent cap mesenchyme to undergo nephrogenesis http://purl.obolibrary.org/obo/MP_0011761 abnormal ureteric bud trunk morphology http://purl.obolibrary.org/obo/MP_0006032 abnormal ureteric bud morphology any structural anomaly of the ureteric bud cells that elongate to form a rigid structure (stalk) consisting of polarized epithelial cells without branching; the stalks differentiate into the collecting system of the mature kidney, while the tip cells interact with the adjacent cells of the metanephric mesenchyme, inducing their conversion into nephrons http://purl.obolibrary.org/obo/MP_0011763 urethritis http://purl.obolibrary.org/obo/MP_0011762 renal/urinary system inflammation local accumulation of fluid, plasma proteins, and leukocytes in the urethra, usually caused by an infection http://purl.obolibrary.org/obo/MP_0011764 ureteritis http://purl.obolibrary.org/obo/MP_0011762 renal/urinary system inflammation local accumulation of fluid, plasma proteins, and leukocytes in a ureter, usually caused by infection or by the mechanic irritation of a stone; the epithelial reaction may be cystic if the reaction is liquefaction, or glandular if the epithelial reaction is by metaplasia http://purl.obolibrary.org/obo/MP_0011765 oroticaciduria http://purl.obolibrary.org/obo/MP_0010028 aciduria increased level of orotic acid, an intermediate of pyrimidine synthesis, in the urine http://purl.obolibrary.org/obo/MP_0011766 abnormal urinary bladder mucosa morphology http://purl.obolibrary.org/obo/MP_0000538 abnormal urinary bladder morphology any structural anomaly of the mucous membrane lining the urinary bladder http://purl.obolibrary.org/obo/MP_0011767 ureterocele http://purl.obolibrary.org/obo/MP_0000534 abnormal ureter morphology saccular dilation of the terminal portion of the ureter that protrudes into the lumen of the urinary bladder, probably due to a congenital stenosis of the ureteric orifice meatus; most often associated with a duplicated collection system, where two ureters drain their respective kidney instead of one http://purl.obolibrary.org/obo/MP_0011768 abnormal urinary bladder trigone morphology http://purl.obolibrary.org/obo/MP_0000538 abnormal urinary bladder morphology any structural anomaly of the smooth triangular region of the wall of the urinary bladder formed by the two ureteral orifices and the internal urethral orifice; it is an area in which the muscle fibers are closely adherent to the mucosa http://purl.obolibrary.org/obo/MP_0011769 urinary bladder fibrosis http://purl.obolibrary.org/obo/MP_0000538 abnormal urinary bladder morphology invasion of fibrous connective tissue into the urinary bladder, often resulting from inflammation or injury http://purl.obolibrary.org/obo/MP_0011770 increased urine selenium level http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis greater than normal amount of selenium in the urine http://purl.obolibrary.org/obo/MP_0011771 abnormal genital tubercle morphology http://purl.obolibrary.org/obo/MP_0003936 abnormal reproductive system development any structural anomaly of the embryonic anlage of the external genitalia, which emerges as paired swellings ventral to the cloacal membrane, is proposed to be derived from all three germ layers, and gives rise to the penis, clitoris, scrotum, labia, and foreskin; GT development is indistinguishable in male and female mouse embryos until approximately E16, when the urethral plate begins to be masculinized to form the penile urethra, marking the beginning of an androgen-dependent phase of sexual differentiation http://purl.obolibrary.org/obo/MP_0011772 genital tubercle hypoplasia http://purl.obolibrary.org/obo/MP_0011771 abnormal genital tubercle morphology underdevelopment or reduced size of the embryonic anlage of the external genitalia, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0011773 abnormal urinary bladder blood vessel morphology http://purl.obolibrary.org/obo/MP_0001614 abnormal blood vessel morphology any structural anomaly of the network of tubes that carries blood through the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys http://purl.obolibrary.org/obo/MP_0011774 abnormal urinary bladder detrusor smooth muscle morphology http://purl.obolibrary.org/obo/MP_0000767 abnormal smooth muscle morphology any structural anomaly of the bundles of smooth muscle fibers forming the muscular wall of the urinary bladder, which are arranged in a longitudinal and a circular layer and, on contraction, serve to expel urine http://purl.obolibrary.org/obo/MP_0011775 rectal atresia http://purl.obolibrary.org/obo/MP_0000492 abnormal rectum morphology congenital absence, closure, or constriction of the lumen of the terminal portion of the intestinal tube adjacent to the anus, leading to abdominal distention after birth http://purl.obolibrary.org/obo/MP_0011776 abnormal male urethra morphology http://purl.obolibrary.org/obo/MP_0000537 abnormal urethra morphology any structural anomaly of the male fibromuscular tubular canal which extends from the internal urethral orifice in the urinary bladder to the external urethral orifice at the tip of the penis and provides an exit for urine as well as semen during ejaculation; the male urethra is longer than the urethra of females and comprises three major portions, the (i) prostatic, (ii) membranous (aka intermediate), and (iii) cavernous (aka spongy or penile) http://purl.obolibrary.org/obo/MP_0011777 abnormal male prostatic urethra morphology http://purl.obolibrary.org/obo/MP_0011776 abnormal male urethra morphology any structural anomaly of the widest and most dilatable part of the male urethra canal which runs almost vertically through the prostate from its base to its apex, lying nearer its anterior than its posterior surface; this portion of the urethral canal is spindle-shaped, being wider in the middle than at either extremity, and narrowest below, where it joins the membranous portion; it is lined by transitional epithelium and contains in its posterior wall, or floor, the orifices of the prostatic utricle, ejaculatory ducts, and prostatic ducts, collectively known as the seminal colliculus (aka verumontanum) http://purl.obolibrary.org/obo/MP_0011778 abnormal male membranous urethra morphology http://purl.obolibrary.org/obo/MP_0011776 abnormal male urethra morphology any structural anomaly of the shortest, least dilatable, and, with the exception of the external orifice, the narrowest part of the male urethral canal located in the deep perineal pouch and lined by pseudostratified columnar epithelium; it extends downward and forward, with a slight anterior concavity, between the apex of the prostate and the bulb of the urethra, perforating the urogenital diaphragm below and behind the pubic symphysis; the membranous portion of the urethra is completely surrounded by the fibers of the sphincter urethrae membranaceae; on either side near its termination are the bulbourethral glands http://purl.obolibrary.org/obo/MP_0011779 abnormal male spongy urethra morphology http://purl.obolibrary.org/obo/MP_0011776 abnormal male urethra morphology any structural anomaly of the that longest part of the male urethra contained in the corpus spongiosum and extending from the end of the membranous portion to the external urethral orifice; commencing below the inferior fascia of the urogenital diaphragm it passes forward and upward to the front of the symphysis pubis; and then, in the flaccid condition of the penis, it bends downward and forward; while narrow and of uniform size in the body of the penis, it is dilated behind, within the bulb, and again anteriorly within the glans penis, where it forms the fossa navicularis urethrae; the spongy urethra is lined by pseudostratified columnar epithelium proximally, and by stratified squamous epithelium distally http://purl.obolibrary.org/obo/MP_0011780 abnormal female urethra morphology http://purl.obolibrary.org/obo/MP_0000537 abnormal urethra morphology any structural anomaly of the short and relatively simple female fibromuscular tubular canal which extends from the urinary bladder outlet to the perineum adjacent to the anterior wall of the vagina, and opens in the vestibule of the vagina posterior to the clitoris and anterior to the vaginal orifice; small mucus urethral glands (Skene's glands) open along its entire length and drain into a single paraurethral duct, which empties at the lateral margin of the external urethral orifice: its epithelial lining changes from transitional epithelium at the bladder end to non-keratinizing stratified squamous epithelium distally http://purl.obolibrary.org/obo/MP_0011781 abnormal bulbourethral gland physiology http://purl.obolibrary.org/obo/MP_0013327 abnormal male reproductive gland physiology any functional anomaly of the small paired racemose (compound tubulo-alveolar) glands below the apex of the prostate in males, located posterolateral to the membranous portion of the urethra at the base of the penis, which produce a clear, salty, viscous secretion known as pre-ejaculate (aka as pre-ejaculatory fluid, preseminal fluid, or Cowper's fluid) upon sexual stimulation; this fluid is believed to lubricate the urethra for spermatozoa to pass through and neutralize traces of acidic urine in the urethra http://purl.obolibrary.org/obo/MP_0011782 abnormal internal urethral orifice morphology http://purl.obolibrary.org/obo/MP_0000516 abnormal renal/urinary system morphology any structural anomaly of the usually crescent-shaped opening of the urinary bladder into the urethra, placed at the anteroinferior angle (apex) of the urinary bladder trigone http://purl.obolibrary.org/obo/MP_0011783 abnormal ureteral orifice morphology http://purl.obolibrary.org/obo/MP_0011488 abnormal ureterovesical junction morphology any structural anomaly of the slit-like opening of either ureter into the bladder; normally, the two ureteral orifices are placed at the posterolateral angles of the urinary bladder trigone while the internal urethral orifice is placed at its anteroinferior angle (apex); wide gaping usually indicates vesicoureteral reflux http://purl.obolibrary.org/obo/MP_0011784 abnormal urinary bladder neck morphology http://purl.obolibrary.org/obo/MP_0000538 abnormal urinary bladder morphology any structural anomaly of the constricted portion of the urinary bladder, formed by the meeting of its inferolateral surfaces proximal to the opening of the urethra http://purl.obolibrary.org/obo/MP_0011785 abnormal urinary bladder fundus morphology http://purl.obolibrary.org/obo/MP_0000538 abnormal urinary bladder morphology any structural anomaly of the base or posterior surface of the urinary bladder, which contains the trigone of the bladder and the outlet where urine empties through the internal urethral orifice http://purl.obolibrary.org/obo/MP_0011786 rectourethral fistula http://purl.obolibrary.org/obo/MP_0000537 abnormal urethra morphology an abnormal anatomical passage connecting the urethra and the rectum http://purl.obolibrary.org/obo/MP_0011787 abnormal Bartholin's gland morphology http://purl.obolibrary.org/obo/MP_0013324 abnormal female reproductive gland morphology any structural anomaly of the paired glands located slightly posterior and to the left and right of the opening of the vagina in the superficial perineal pouch in females; they secrete mucus to lubricate the vagina and are homologous to bulbourethral (Cowper's) glands in males http://purl.obolibrary.org/obo/MP_0011788 absent urethra http://purl.obolibrary.org/obo/MP_0000537 abnormal urethra morphology absence or failure to form of any part of the male or female urethra http://purl.obolibrary.org/obo/MP_0011789 increased urethra carcinoma incidence http://purl.obolibrary.org/obo/MP_0010289 increased urinary system tumor incidence greater than the expected number of malignant neoplasms arising from the epithelial lining of the urethra in a given population in a given time period http://purl.obolibrary.org/obo/MP_0011790 increased urethral gland adenocarcinoma incidence http://purl.obolibrary.org/obo/MP_0010289 increased urinary system tumor incidence greater than the expected number of malignant neoplasms arising from urothelial lining or surrounding glands of the urethra in a given population in a given time period http://purl.obolibrary.org/obo/MP_0011791 increased bulbourethral gland adenocarcinoma incidence http://purl.obolibrary.org/obo/MP_0010289 increased urinary system tumor incidence greater than the expected number of malignant neoplasm of epithelial cells in the bulbourethral glands, usually with a glandular organization in a given population in a given time period http://purl.obolibrary.org/obo/MP_0011792 abnormal urethral gland morphology http://purl.obolibrary.org/obo/MP_0002163 abnormal gland morphology any structural anomaly of any of the numerous small mucous-secreting glands located in the wall of the male or female urethra that help protect the epithelium from the corrosive urine http://purl.obolibrary.org/obo/MP_0011793 abnormal female urethral gland morphology http://purl.obolibrary.org/obo/MP_0011792 abnormal urethral gland morphology any structural anomaly of the numerous mucous-secreting glands found in several female mammalian species (including rodents and humans) on the anterior wall of the vagina, around the lower end of the urethra, and possessing a common paraurethral duct which opens (on each side) near the external urethral orifice; they are homologous with the prostate gland in males, have highly variable anatomy, and are believed to be the source of the female ejaculate, a lubricating fluid with a similar consistency to male prostatic fluid that is expelled through the urethra during sexual stimulation; like the male prostate, these glands are susceptible to infection (skenitis), cyst development, and cancer http://purl.obolibrary.org/obo/MP_0011794 abnormal male urethral gland morphology http://purl.obolibrary.org/obo/MP_0011792 abnormal urethral gland morphology any structural anomaly of any of the numerous small mucous-secreting glands located in the wall of the penile urethra http://purl.obolibrary.org/obo/MP_0011795 abnormal urinary bladder development http://purl.obolibrary.org/obo/MP_0003942 abnormal urinary system development incomplete or aberrant differentiation of the distensible musculomembranous organ situated in the anterior part of the pelvic cavity in which urine collects before excretion http://purl.obolibrary.org/obo/MP_0011797 blind ureter http://purl.obolibrary.org/obo/MP_0000534 abnormal ureter morphology a ureter ending in a blind-ended segment or pouch http://purl.obolibrary.org/obo/MP_0011798 abnormal urinary bladder weight http://purl.obolibrary.org/obo/MP_0000538 abnormal urinary bladder morphology anomaly in the average weight of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys compared to controls http://purl.obolibrary.org/obo/MP_0011799 increased urinary bladder weight http://purl.obolibrary.org/obo/MP_0011798 abnormal urinary bladder weight greater than average weight of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys compared to controls http://purl.obolibrary.org/obo/MP_0011800 decreased urinary bladder weight http://purl.obolibrary.org/obo/MP_0011798 abnormal urinary bladder weight less than average weight of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys compared to controls http://purl.obolibrary.org/obo/MP_0011801 urethra obstruction http://purl.obolibrary.org/obo/MP_0000537 abnormal urethra morphology any impediment or blockage of the canal through which urine is discharged from the bladder in most mammals and through which semen is discharged in the male; usually caused by calculus, or plugs composed of proteinaceous material, cellular debris and possibly crystals http://purl.obolibrary.org/obo/MP_0011802 seminal vesiculitis http://purl.obolibrary.org/obo/MP_0002254 reproductive system inflammation local accumulation of fluid, plasma proteins, and leukocytes in the seminal vesicle(s), usually caused by an infection http://purl.obolibrary.org/obo/MP_0011803 double kidney pelvis http://purl.obolibrary.org/obo/MP_0004194 abnormal kidney pelvis morphology duplication of the funnel shaped proximal portion of the ureter that is formed by convergence of the major calices http://purl.obolibrary.org/obo/MP_0011806 decreased dermal fibroblast proliferation http://purl.obolibrary.org/obo/MP_0011704 decreased fibroblast proliferation reduction in the expansion rate of a dermal fibroblast cell population by cell division http://purl.obolibrary.org/obo/MP_0011807 decreased lung fibroblast proliferation http://purl.obolibrary.org/obo/MP_0011704 decreased fibroblast proliferation reduction in the expansion rate of a lung fibroblast cell population by cell division http://purl.obolibrary.org/obo/MP_0011808 abnormal myoblast differentiation http://purl.obolibrary.org/obo/MP_0005076 abnormal cell differentiation anomaly in the process in which a relatively unspecialized cell acquires specialized features of a myoblast, a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into striated muscle fibers http://purl.obolibrary.org/obo/MP_0011809 abnormal anoikis http://purl.obolibrary.org/obo/MP_0001648 abnormal apoptosis anomaly in the apoptosis response triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix http://purl.obolibrary.org/obo/MP_0011810 increased anoikis http://purl.obolibrary.org/obo/MP_0011809 abnormal anoikis increase in the apoptosis response triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix http://purl.obolibrary.org/obo/MP_0011811 decreased anoikis http://purl.obolibrary.org/obo/MP_0011809 abnormal anoikis reduction in the apoptosis response triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix http://purl.obolibrary.org/obo/MP_0011812 increased cranium length http://purl.obolibrary.org/obo/MP_0010031 abnormal cranium size having an increased dorsal-to-ventral distance of the cranium http://purl.obolibrary.org/obo/MP_0011813 long maxilla http://purl.obolibrary.org/obo/MP_0000455 abnormal maxilla morphology increased length of the upper jaw bone http://purl.obolibrary.org/obo/MP_0011814 abnormal pre-pro B cell morphology http://purl.obolibrary.org/obo/MP_0005432 abnormal pro-B cell morphology any structural anomaly of a pro-B cell that CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive http://purl.obolibrary.org/obo/MP_0011815 increased pre-pro B cell number http://purl.obolibrary.org/obo/MP_0011814 abnormal pre-pro B cell morphology increased number of pro-B cells that are CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative; this cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive http://purl.obolibrary.org/obo/MP_0011816 decreased pre-pro B cell number http://purl.obolibrary.org/obo/MP_0011814 abnormal pre-pro B cell morphology reduced number of pro-B cells that are CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative; this cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive http://purl.obolibrary.org/obo/MP_0011817 absent pre-pro B cells http://purl.obolibrary.org/obo/MP_0011816 decreased pre-pro B cell number absence of pro-B cells that are CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative; this cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive http://purl.obolibrary.org/obo/MP_0011818 abnormal pancreatic beta cell proliferation http://purl.obolibrary.org/obo/MP_0003562 abnormal pancreatic beta cell physiology anomaly in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0011819 increased pancreatic beta cell proliferation http://purl.obolibrary.org/obo/MP_0011818 abnormal pancreatic beta cell proliferation increase in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0011820 decreased pancreatic beta cell proliferation http://purl.obolibrary.org/obo/MP_0011818 abnormal pancreatic beta cell proliferation reduction in the ability of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0011821 abnormal CD8-positive, alpha-beta memory T cell proliferation http://purl.obolibrary.org/obo/MP_0008051 abnormal memory T cell physiology anomaly in the ability of the a CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high, to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0011822 increased CD8-positive, alpha-beta memory T cell proliferation http://purl.obolibrary.org/obo/MP_0011821 abnormal CD8-positive, alpha-beta memory T cell proliferation increase in the ability of the a CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high, to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0011823 decreased CD8-positive, alpha-beta memory T cell proliferation http://purl.obolibrary.org/obo/MP_0011821 abnormal CD8-positive, alpha-beta memory T cell proliferation reduction in the ability of the a CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive, or also described as being CD25-negative, CD44-high, and CD122- high, to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0011824 increased cell chemotaxis http://purl.obolibrary.org/obo/MP_0011804 increased cell migration increase in the directed movement response of a motile cell guided by a specific chemical concentration gradient; movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis) http://purl.obolibrary.org/obo/MP_0011825 decreased cell chemotaxis http://purl.obolibrary.org/obo/MP_0011805 decreased cell migration reduciton in the directed movement response of a motile cell guided by a specific chemical concentration gradient; movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis) http://purl.obolibrary.org/obo/MP_0011826 increased lymphocyte chemotaxis http://purl.obolibrary.org/obo/MP_0011824 increased cell chemotaxis any anomaly in the directed movement of a lymphocyte in response to an external stimulus http://purl.obolibrary.org/obo/MP_0011827 impaired neuron differentiation http://purl.obolibrary.org/obo/MP_0009937 abnormal neuron differentiation decreased production of or inability to produce the mature cells of the nervous system that receive, conduct, and transmit impulses http://purl.obolibrary.org/obo/MP_0011828 urinary bladder cysts http://purl.obolibrary.org/obo/MP_0000538 abnormal urinary bladder morphology abnormal membranous pouches or sacs usually filled with a fluid or viscous substance found along the internal lining of the urinary bladder http://purl.obolibrary.org/obo/MP_0011829 vesicovaginal fistula http://purl.obolibrary.org/obo/MP_0001139 abnormal vagina morphology an abnormal fistulous tract extending between the bladder and the vagina, with resulting leakage of urine into the vaginal cavity http://purl.obolibrary.org/obo/MP_0011830 ectopic hair follicle melanin granules http://purl.obolibrary.org/obo/MP_0005072 abnormal hair follicle melanin granule morphology any aberration in normal location of pigment granules in the hair follicle that results in variation from expected hair color http://purl.obolibrary.org/obo/MP_0011831 abnormal visual contrast sensitivity http://purl.obolibrary.org/obo/MP_0002090 abnormal vision any abnormality in the ability to distinguish between increments of light versus dark http://purl.obolibrary.org/obo/MP_0011833 abnormal cremaster muscle morphology http://purl.obolibrary.org/obo/MP_0000759 abnormal skeletal muscle morphology any structural anomaly of the thin layer of skeletal muscle that envelops the spermatic cord and testis of most male mammals in a series of loops; it is a continuation of the obliquus internus, arising from the inguinal ligament and inserting into the crest of the pubis and into the sheath of the rectus abdominis; it is innervated by the genital branch of the genitofemoral nerve and functions to draw the testis up toward the superficial inguinal ring in response to cold or to stimulation of the nerve; in females it is represented by only a few muscle loops that envelop the round ligament of the uterus http://purl.obolibrary.org/obo/MP_0011834 abnormal female preputial gland morphology http://purl.obolibrary.org/obo/MP_0013329 abnormal preputial gland morphology any structural anomaly of the paired, lobulated, modified sebaceous glands located on the side of the clitoris in female rodents; in contrast to the preputial glands in male rodents, clitoral glands are a minor source of olfactory stimuli contributing to sexual attractivity; unlike other sebaceous glands, they undergo progressive atrophy of the glandular portion with marked ductal ectasia as rodents age; there is no true anatomical equivalent in humans http://purl.obolibrary.org/obo/MP_0011835 abnormal urogenital fold morphology http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology any structural anomaly of the pair of folds derived from the cloacal folds which give rise to a portion of the external genitalia; in male embryos they close over the urethral plate and fuse to form the spongy (penile) urethra and ventral aspect of the penis, not including the glans; failure of fusion of the urethral folds leads to hypospadias; in female embryos they fuse only anterior to the anus and form the labia minora http://purl.obolibrary.org/obo/MP_0011836 abnormal cloacal fold morphology http://purl.obolibrary.org/obo/MP_0010115 abnormal embryonic cloaca morphology any structural anomaly of the pair of mesenchymal swellings (folds) located on either side of the cloacal membrane during the indifferent stage of embryonic development; cranial to the cloacal membrane the folds unite to form the genital tubercle; caudally the folds are subdivided into urogenital folds anteriorly and anal folds posteriorly http://purl.obolibrary.org/obo/MP_0011837 abnormal cloacal membrane morphology http://purl.obolibrary.org/obo/MP_0010115 abnormal embryonic cloaca morphology any structural anomaly of the membrane that covers the embryonic cloaca, formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm; the urorectal septum joins the cloacal membrane and divides it into an anal membrane and a urogenital membrane; the point where the urorectal septum intersects the cloacal membrane is the future site of the perineal body; proliferation of mesoderm and ectoderm around the cloacal membrane produces primordial tissues of the external genitalia in both sexes: the genital tubercle, genital folds, and genital swellings http://purl.obolibrary.org/obo/MP_0011838 abnormal navicular fossa morphology http://purl.obolibrary.org/obo/MP_0011779 abnormal male spongy urethra morphology any structural anomaly of the dilated terminal portion of the male spongy urethra located in the glans penis right before the external urethral orifice, also referred to as the most distal pendulous urethra; it is lined by stratified squamous, non-keratinizing epithelium; during development, the glans of the penis is initially solid but cannulates to give rise to the navicular fossa http://purl.obolibrary.org/obo/MP_0011839 abnormal Guérin's valve morphology http://purl.obolibrary.org/obo/MP_0011838 abnormal navicular fossa morphology any structural anomaly of the fold or valve of mucus membrane on the upper wall of the navicuar fossa http://purl.obolibrary.org/obo/MP_0011840 abnormal urethral crest morphology http://purl.obolibrary.org/obo/MP_0000537 abnormal urethra morphology any structural anomaly of the longitudinal mucosal fold in the dorsal wall of the urethra http://purl.obolibrary.org/obo/MP_0011841 abnormal male urethral crest morphology http://purl.obolibrary.org/obo/MP_0011840 abnormal urethral crest morphology any structural anomaly of the narrow longitudinal fold of mucosa on the posterior wall of the male urethra, extending from the uvula of the bladder through the prostatic urethra; when distended, it may serve to prevent the passage of the semen backward into the bladder; on either side of the male urethral crest is a slightly depressed fossa, the prostatic sinus, the floor of which is perforated by the orifices of the prostatic ducts from the lateral lobes of the prostate; the ducts of the middle lobe open behind the crest; at the forepart of the crest, below its summit, is a median elevation, the colliculus seminalis, upon or within the margins of which are the orifices of the prostatic utricle and the slit-like openings of the ejaculatory ducts http://purl.obolibrary.org/obo/MP_0011842 abnormal female urethral crest morphology http://purl.obolibrary.org/obo/MP_0011840 abnormal urethral crest morphology any structural anomaly of the conspicuous longitudinal fold of mucosa on the posterior wall of the female urethra http://purl.obolibrary.org/obo/MP_0011843 abnormal kidney collecting duct epithelium morphology http://purl.obolibrary.org/obo/MP_0004754 abnormal kidney collecting duct morphology any structural anomaly of the simple cuboidal epithelium lining the lumen of kidney collecting ducts; the mature and differentiated CD epithelium comprises two unique cells types with principal cells responsible for vasopressin-regulated water reabsorption, and intercalated cells regulating acid-base homeostasis; injury to the epithelium is believed to cause epithelial cells to acquire mesenchymal characteristics via epithelial-mesenchymal transition (EMT), a process through which tubular epithelial cells may transform into interstitial fibroblasts and promote renal fibrosis http://purl.obolibrary.org/obo/MP_0011844 kidney collecting duct atrophy http://purl.obolibrary.org/obo/MP_0004754 abnormal kidney collecting duct morphology acquired diminution of the size of the kidney collecting ducts associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0011845 abnormal kidney collecting duct number http://purl.obolibrary.org/obo/MP_0004754 abnormal kidney collecting duct morphology anomaly in the number of any of the kidney ducts that collect urine from the distal convoluted tubules, merge and become larger as they descend from the renal cortex into the medulla, and respond to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance http://purl.obolibrary.org/obo/MP_0011846 decreased kidney collecting duct number http://purl.obolibrary.org/obo/MP_0011845 abnormal kidney collecting duct number smaller than expected number of the kidney ducts that collect urine from the distal convoluted tubules, merge and become larger as they descend from the renal cortex into the medulla, and respond to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance http://purl.obolibrary.org/obo/MP_0011847 increased kidney collecting duct number http://purl.obolibrary.org/obo/MP_0011845 abnormal kidney collecting duct number larger than expected number of the kidney ducts that collect urine from the distal convoluted tubules, merge and become larger as they descend from the renal cortex into the medulla, and respond to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance http://purl.obolibrary.org/obo/MP_0011848 abnormal vagina vestibule morphology http://purl.obolibrary.org/obo/MP_0003126 abnormal external female genitalia morphology any structural anomaly of the space posterior to the glans clitoridis, between the labia minora; located within the vestibule are the openings of the vagina, the urethra, and the ducts of the lesser vestibular glands, the greater vestibular (Bartholin's) glands, and the paraurethral (Skene's) glands, which release mucus into the vestibule to maintain a moist, lubricated vestibular environment; the vestibule is also moistened by secretions from the cervical mucus glands located in the inferior region of the uterus http://purl.obolibrary.org/obo/MP_0011849 abnormal clitoral bone morphology http://purl.obolibrary.org/obo/MP_0005508 abnormal skeleton morphology any structural anomaly of the ossified region of endochondral and membranous bone located in the clitoris of most mammals except humans;it is homologous to the penile bone (aka as baculum, penis bone or os penis) in male mammals http://purl.obolibrary.org/obo/MP_0011850 absent clitoral bone http://purl.obolibrary.org/obo/MP_0011849 abnormal clitoral bone morphology absence of the unique bone located in the clitoris of most mammals except humans http://purl.obolibrary.org/obo/MP_0011851 abnormal embryonic cloaca development http://purl.obolibrary.org/obo/MP_0010115 abnormal embryonic cloaca morphology failure or anomaly in the formation of a pouch-like dilation of the caudal end of the hindgut by the process of folding of the caudal region of the embryonic disk; during the tail-fold process, the posteriorly placed allantois, or allantoic diverticulum of the yolk sac, becomes an anterior extension of the cloaca; soon after the cloaca forms, it receives posterolaterally the caudal ends of the paired mesonephric ducts and hence becomes a junctional cistern for the allantois, the hindgut, and the ducts; a cloacal membrane, composed of ectoderm and endoderm, is the caudal limit of the primitive gut and temporarily separates the cloacal cavity from the extraembryonic confines of the amniotic cavity; subsequent growth of the urorectal septum eventually subdivides the once single cloaca chamber into the primitive urogenital sinus (ventrally) and the anorectal canal of the hindgut (dorsally) http://purl.obolibrary.org/obo/MP_0011852 patent urachus http://purl.obolibrary.org/obo/MP_0003616 abnormal urachus morphology failure of complete urachal lumen closure resulting in an open channel between the urinary bladder and the umbilicus and leakage of urine through the umbilicus http://purl.obolibrary.org/obo/MP_0011853 abnormal urorectal septum morphology http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology any structural anomaly of the ridge of mesoderm covered with endoderm that in the early developing embryo partitions the endodermal cloaca into the primary urogenital sinus (ventrally) and the anorectal canal of the hindgut (dorsally); the urorectal septum eventually fuses with the cloacal membrane, dividing it into a dorsal anal membrane and a larger ventral urogenital membrane - this area of fusion is represented in the adult by the perineal body http://purl.obolibrary.org/obo/MP_0011854 cerebral edema http://purl.obolibrary.org/obo/MP_0001785 edema excess accumulation of water in the intra- and/or extracellular spaces of the brain http://purl.obolibrary.org/obo/MP_0011855 abnormal glomerular filtration barrier morphology http://purl.obolibrary.org/obo/MP_0005325 abnormal renal glomerulus morphology any structural anomaly of the highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules; its integrity is maintained by physicochemical and signalling interplay among its three core constituents -- the fenestrated endothelium of the glomerular capillaries, the glomerular basement membrane, and the filtration slits of the visceral epithelial cell (podocyte) http://purl.obolibrary.org/obo/MP_0011856 abnormal glomerular filtration barrier function http://purl.obolibrary.org/obo/MP_0013284 abnormal renal glomerular filtration anomaly in the function of the highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules; its integrity is maintained by physicochemical and signalling interplay among its three core constituents -- the fenestrated endothelium of the glomerular capillaries, the glomerular basement membrane, and the filtration slits of the visceral epithelial cell (podocyte); the barrier permits the passage of water, ions, and small molecules from the bloodstream into the Bowman's space and prevents the loss of large and/or negatively charged proteins (e.g. serum albumin) from blood into urine http://purl.obolibrary.org/obo/MP_0011857 short kidney papilla http://purl.obolibrary.org/obo/MP_0004193 abnormal kidney papilla morphology reduced average length of the apex of the renal pyramid that projects into a calyx http://purl.obolibrary.org/obo/MP_0011858 elongated kidney papilla http://purl.obolibrary.org/obo/MP_0004193 abnormal kidney papilla morphology increased average length of the apex of the renal pyramid that projects into a calyx http://purl.obolibrary.org/obo/MP_0011859 decreased renal glomerulus basement membrane thickness http://purl.obolibrary.org/obo/MP_0011349 abnormal renal glomerulus basement membrane thickness reduced width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule http://purl.obolibrary.org/obo/MP_0011860 abnormal peritubular capillary endothelium morphology http://purl.obolibrary.org/obo/MP_0011321 abnormal peritubular capillary morphology any structural anomaly of the thin sheet of endothelial cells along the basal lamina of renal tubular cells characterized by their attenuated shape and numerous regularly-spaced transcellular pores (aka fenestrae or fenestrations); the fenestrae of peritubular capillaries differ from the fenestrae of glomerular capillaries in that they are much smaller and possess a small overlying diaphragm http://purl.obolibrary.org/obo/MP_0011861 increased cranium height http://purl.obolibrary.org/obo/MP_0010031 abnormal cranium size increase in the rostral-caudal distance between the cranial base and the upper domelike portion of the skull http://purl.obolibrary.org/obo/MP_0011862 decreased cranium length http://purl.obolibrary.org/obo/MP_0010031 abnormal cranium size having an decreased dorsal-to-ventral distance of the cranium http://purl.obolibrary.org/obo/MP_0011863 abnormal podocyte physiology http://purl.obolibrary.org/obo/MP_0002136 abnormal kidney physiology any functional anomaly of a modified epithelial cell of the visceral layer of the Bowman capsule in the renal corpuscle; it has a small perikaryon and a number of primary and secondary foot processes that interdigitate with those of other podocytes and are attached to the outer surface of the glomerular capillary basement membrane http://purl.obolibrary.org/obo/MP_0011864 abnormal podocyte adhesion http://purl.obolibrary.org/obo/MP_0011863 abnormal podocyte physiology any anomaly in the adhesive properties of glomerular podocytes, resulting in abnormal cell to cell and cell to extracellular matrix (ECM) interactions; podocytes adhere tightly to ECM components of the glomerular basement membrane via an integrin-laminin-actin axis to maintain a functional filtration barrier in the presence of mechanical stress http://purl.obolibrary.org/obo/MP_0011865 abnormal podocyte motility http://purl.obolibrary.org/obo/MP_0011863 abnormal podocyte physiology any anomaly in the ability of podocyte foot processes (FPs) to retract or elongate and hence move quickly along the glomerular basement membrane (GBM); motility refers to the dynamic reorganization of the interdigitating FP structure in vivo , and to the cell migration of cultured podocytes in vitro that is seen as surrogate for the former; alterations in podocyte motility are considered to underlie foot process effacement, with changes in the leading edge of the cell and its interactions with the GBM; a rather stationary podocyte phenotype is believed to reflect a stable FP structure with intact slit diaphragms, whereas hypermotility is believed to promote the development of FP effacement and proteinuria http://purl.obolibrary.org/obo/MP_0011866 increased podocyte motility http://purl.obolibrary.org/obo/MP_0011865 abnormal podocyte motility greater ability of podocyte foot processes (FPs) to retract or elongate and hence move quickly along the glomerular basement membrane (GBM) http://purl.obolibrary.org/obo/MP_0011867 decreased podocyte motility http://purl.obolibrary.org/obo/MP_0011865 abnormal podocyte motility reduced ability of podocyte foot processes (FPs) to retract or elongate and hence move quickly along the glomerular basement membrane (GBM) http://purl.obolibrary.org/obo/MP_0011868 podocyte microvillus transformation http://purl.obolibrary.org/obo/MP_0005326 abnormal podocyte morphology aberrant formation of numerous slender cellular projections resembling microvilli or vesicle-like structures along the apical surface of podocytes, suggestive of podocyte injury http://purl.obolibrary.org/obo/MP_0011869 detached podocyte http://purl.obolibrary.org/obo/MP_0011864 abnormal podocyte adhesion detachment or loss of adhesion of podocyte foot processes from the glomerular basement membrane (GBM); as a consequence, denuded GBM areas at peripheral capillary loops can become foci for adhesions to parietal epithelial cells (glomerular synechiae) and crescent formation, and podocytes and podocyte-specific proteins may be found in the urine http://purl.obolibrary.org/obo/MP_0011870 abnormal podocyte polarity http://purl.obolibrary.org/obo/MP_0005326 abnormal podocyte morphology any anomaly in the establishment or maintenance of podocyte cell polarity; podocytes exhibit polarity along at least two axes: (i) an apical-basal axis perpendicular to the glomerular basement membrane in which the apical and basolateral membrane domains of the podocyte are separated by a boundary created by the intercellular junctions of the foot process and (ii) a second plane parallel to the basement membrane that determines the unique orientation of interdigitating foot processes http://purl.obolibrary.org/obo/MP_0011871 podocyte hypertrophy http://purl.obolibrary.org/obo/MP_0005326 abnormal podocyte morphology increase in the bulk size of the modified epithelial cell of the visceral layer of the Bowman capsule in the renal corpuscle, due to cell enlargement http://purl.obolibrary.org/obo/MP_0011872 absent xiphoid process http://purl.obolibrary.org/obo/MP_0000159 abnormal xiphoid process morphology absence of the caudal tip of the sternum http://purl.obolibrary.org/obo/MP_0011873 enlarged uterine horn http://purl.obolibrary.org/obo/MP_0009085 abnormal uterine horn morphology increased size of the uterine horn http://purl.obolibrary.org/obo/MP_0011874 enlarged urinary bladder http://purl.obolibrary.org/obo/MP_0000538 abnormal urinary bladder morphology increased size of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys http://purl.obolibrary.org/obo/MP_0011875 absent stomach http://purl.obolibrary.org/obo/MP_0000470 abnormal stomach morphology absence of the sac-like structure of the digestive canal between the esophagus and the small intestine http://purl.obolibrary.org/obo/MP_0011876 absent penis http://purl.obolibrary.org/obo/MP_0005187 abnormal penis morphology absence of organ of copulation and urination in the male http://purl.obolibrary.org/obo/MP_0011877 absent liver http://purl.obolibrary.org/obo/MP_0000598 abnormal liver morphology absence of the bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage http://purl.obolibrary.org/obo/MP_0011878 jejunum atresia http://purl.obolibrary.org/obo/MP_0004002 abnormal jejunum morphology congenital blockage or absence of the lumen of the jejunum http://purl.obolibrary.org/obo/MP_0011879 ileum atresia http://purl.obolibrary.org/obo/MP_0002581 abnormal ileum morphology congenital blockage or absence of the lumen of the ileum http://purl.obolibrary.org/obo/MP_0011880 absent duodenum http://purl.obolibrary.org/obo/MP_0003271 abnormal duodenum morphology missing portion of the small intestine that extends from the pyloris to the junction with the jejunum http://purl.obolibrary.org/obo/MP_0011881 distended duodenum http://purl.obolibrary.org/obo/MP_0003271 abnormal duodenum morphology an expansion in the volume of the portion of the small intestine that extends from the pyloris to the junction with the jejunum, as by stretching or distention http://purl.obolibrary.org/obo/MP_0011882 enlarged duodenum http://purl.obolibrary.org/obo/MP_0003271 abnormal duodenum morphology increased size of the portion of the small intestine that extends from the pyloris to the junction with the jejunum http://purl.obolibrary.org/obo/MP_0011883 absent diaphragm http://purl.obolibrary.org/obo/MP_0002279 abnormal diaphragm morphology absence of the thin musculomebranous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control http://purl.obolibrary.org/obo/MP_0011884 absent colon http://purl.obolibrary.org/obo/MP_0000495 abnormal colon morphology absence of the portion of the large intestine between the cecum and the rectum http://purl.obolibrary.org/obo/MP_0011885 abnormal circulating lipase level http://purl.obolibrary.org/obo/MP_0001570 abnormal circulating enzyme level any anomaly in the concentration of lipase in the blood, in particular the serum; the measurement of serum lipase activity is widely used for the diagnosis of acute pancreatitis http://purl.obolibrary.org/obo/MP_0011886 increased circulating lipase level http://purl.obolibrary.org/obo/MP_0011885 abnormal circulating lipase level elevated blood level of lipase in the blood, in particular the serum http://purl.obolibrary.org/obo/MP_0011887 decreased circulating lipase level http://purl.obolibrary.org/obo/MP_0011885 abnormal circulating lipase level reduced blood level of lipase in the blood, in particular the serum http://purl.obolibrary.org/obo/MP_0011889 abnormal circulating ferritin level http://purl.obolibrary.org/obo/MP_0005416 abnormal circulating protein level deviation from the normal concentration of ferritin, a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion; some ferritin is also found in the blood and is measured in tests for overall iron levels, anemia and chronic diseases http://purl.obolibrary.org/obo/MP_0011890 increased circulating ferritin level http://purl.obolibrary.org/obo/MP_0011889 abnormal circulating ferritin level elevated concentration in the blood of ferritin, a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion; some ferritin is also found in the blood and is measured in tests for overall iron levels, anemia and chronic diseases http://purl.obolibrary.org/obo/MP_0011891 decreased circulating ferritin level http://purl.obolibrary.org/obo/MP_0011889 abnormal circulating ferritin level reduced concentration in the blood of ferritin, a ubiquitous intracellular protein that stores iron and releases it in a controlled fashion; some ferritin is also found in the blood and is measured in tests for overall iron levels, anemia and chronic diseases http://purl.obolibrary.org/obo/MP_0011892 abnormal circulating transferrin level http://purl.obolibrary.org/obo/MP_0005416 abnormal circulating protein level deviation from the normal concentration in the blood of a plasma protein that reversibly binds and transports iron and other metal ions through the blood to the liver, spleen and bone marrow http://purl.obolibrary.org/obo/MP_0011893 increased circulating transferrin level http://purl.obolibrary.org/obo/MP_0011892 abnormal circulating transferrin level elevated concentration in the blood of a plasma protein that reversibly binds and transports iron and other metal ions through the blood to the liver, spleen and bone marrow http://purl.obolibrary.org/obo/MP_0011894 decreased circulating transferrin level http://purl.obolibrary.org/obo/MP_0011892 abnormal circulating transferrin level reduced concentration in the blood of a plasma protein that reversibly binds and transports iron and other metal ions through the blood to the liver, spleen and bone marrow http://purl.obolibrary.org/obo/MP_0011895 abnormal circulating unsaturated transferrin level http://purl.obolibrary.org/obo/MP_0011892 abnormal circulating transferrin level any anomaly in the concentration of transferrin that is not saturated (bound) with iron; this represents the reserve capacity of transferrin and is often measured by the Unsaturated Iron Binding Capacity (UIBC) test http://purl.obolibrary.org/obo/MP_0011896 increased circulating unsaturated transferrin level http://purl.obolibrary.org/obo/MP_0011895 abnormal circulating unsaturated transferrin level increase in the concentration of transferrin that is not saturated (bound) with iron; this represents the reserve capacity of transferrin and is often measured by the Unsaturated Iron Binding Capacity (UIBC) test http://purl.obolibrary.org/obo/MP_0011897 decreased circulating unsaturated transferrin level http://purl.obolibrary.org/obo/MP_0011895 abnormal circulating unsaturated transferrin level reduction in the concentration of transferrin that is not saturated (bound) with iron; this represents the reserve capacity of transferrin and is often measured by the Unsaturated Iron Binding Capacity (UIBC) test http://purl.obolibrary.org/obo/MP_0011899 podocyte vacuolization http://purl.obolibrary.org/obo/MP_0005326 abnormal podocyte morphology abnormal presence of cavities or fluid-filled vesicles in the cytoplasm of the modified epithelial cell of the visceral layer of the Bowman capsule in the renal corpuscle, often indicative of podocyte injury http://purl.obolibrary.org/obo/MP_0011900 podocyturia http://purl.obolibrary.org/obo/MP_0009643 abnormal urine homeostasis presence of kidney podocytes, their cell fragments, or podocyte-specific proteins in the urine; urinary loss of viable podocytes may serve as a diagnostic tool for pre-eclampsia and as a marker of active renal disease http://purl.obolibrary.org/obo/MP_0011901 abnormal hematopoietic stem cell proliferation http://purl.obolibrary.org/obo/MP_0010763 abnormal hematopoietic stem cell physiology anomaly in the ability of a hematopoietic stem cell population to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0011902 increased hematopoietic stem cell proliferation http://purl.obolibrary.org/obo/MP_0011901 abnormal hematopoietic stem cell proliferation increase in the expansion rate of a hematopoietic stem cell population by cell division http://purl.obolibrary.org/obo/MP_0011903 decreased hematopoietic stem cell proliferation http://purl.obolibrary.org/obo/MP_0011901 abnormal hematopoietic stem cell proliferation reduction in the expansion rate of a hematopoietic stem cell population by cell division http://purl.obolibrary.org/obo/MP_0011904 abnormal Schwann cell physiology http://purl.obolibrary.org/obo/MP_0003690 abnormal glial cell physiology any functional anomaly of the cells which form the insulating myelin sheaths of peripheral axons http://purl.obolibrary.org/obo/MP_0011905 abnormal Schwann cell proliferation http://purl.obolibrary.org/obo/MP_0011904 abnormal Schwann cell physiology any anomaly in the ability of a Schwann cell to undergo rapid expansion by cell division http://purl.obolibrary.org/obo/MP_0011906 increased Schwann cell proliferation http://purl.obolibrary.org/obo/MP_0011905 abnormal Schwann cell proliferation increase in the expansion rate of a Schwann cell population by cell division http://purl.obolibrary.org/obo/MP_0011907 decreased Schwann cell proliferation http://purl.obolibrary.org/obo/MP_0011905 abnormal Schwann cell proliferation reduction in the expansion rate of a Schwann cell population by cell division http://purl.obolibrary.org/obo/MP_0011908 abnormal pancreatic endocrine progenitor cell proliferation http://purl.obolibrary.org/obo/MP_0011911 abnormal pancreatic endocrine progenitor cell physiology anomaly in the ability of a pancreatic endocrine progenitor cell population to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0011909 increased pancreatic endocrine progenitor cell proliferation http://purl.obolibrary.org/obo/MP_0011908 abnormal pancreatic endocrine progenitor cell proliferation increased ability of a pancreatic endocrine progenitor cell population to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0011910 decreased pancreatic endocrine progenitor cell proliferation http://purl.obolibrary.org/obo/MP_0011908 abnormal pancreatic endocrine progenitor cell proliferation reduced ability of a pancreatic endocrine progenitor cell population to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0011911 abnormal pancreatic endocrine progenitor cell physiology http://purl.obolibrary.org/obo/MP_0010147 abnormal endocrine pancreas physiology any functional anomaly of a multi-fate stem cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells http://purl.obolibrary.org/obo/MP_0011912 abnormal circulating fibronectin level http://purl.obolibrary.org/obo/MP_0005416 abnormal circulating protein level aberrant concentration in the blood of the glycoprotein that binds to integrins or components of the extracellular matrix; plays a major role in cell adhesion, growth, migration, differentiation, wound healing, and embryonic development http://purl.obolibrary.org/obo/MP_0011914 decreased heart left atrium weight http://purl.obolibrary.org/obo/MP_0020206 abnormal heart left atrium weight less than average weight of the left atrium http://purl.obolibrary.org/obo/MP_0011915 increased heart left atrium weight http://purl.obolibrary.org/obo/MP_0020206 abnormal heart left atrium weight more than average weight of the left atrium http://purl.obolibrary.org/obo/MP_0011916 decreased heart right atrium weight http://purl.obolibrary.org/obo/MP_0020207 abnormal heart right atrium weight less than average weight of the right atrium http://purl.obolibrary.org/obo/MP_0011917 increased heart right atrium weight http://purl.obolibrary.org/obo/MP_0020207 abnormal heart right atrium weight more than average weight of the right atrium http://purl.obolibrary.org/obo/MP_0011918 abnormal PQ interval http://purl.obolibrary.org/obo/MP_0010508 abnormal heart electrocardiography waveform feature anomaly in the length of time between the beginning of atrial depolarization and the end of atrial repolarization (or recovery), measured by the interval from the beginning of the P wave to the end of the Q wave http://purl.obolibrary.org/obo/MP_0011919 abnormal R wave http://purl.obolibrary.org/obo/MP_0010508 abnormal heart electrocardiography waveform feature any anomaly in the R wave which represents ventricular depolarization and corresponds to electrical impulses rather than mechanical ventricular contractions; irregular or multiple R waves may indicate arrhythmia and the shape of the R waves may indicate ventricular problems http://purl.obolibrary.org/obo/MP_0011920 abnormal S wave http://purl.obolibrary.org/obo/MP_0010508 abnormal heart electrocardiography waveform feature any anomaly in the S wave which represents the end of ventricular depolarization and corresponds to an isoelectric state rather than mechanical ventricular relaxation http://purl.obolibrary.org/obo/MP_0011921 abnormal zona intermedia morphology http://purl.obolibrary.org/obo/MP_0008288 abnormal adrenal cortex morphology any structural anomaly of the region between the zona glomerulosa and zona fasciculata that is relatively thin and contains mostly undifferentiated cells http://purl.obolibrary.org/obo/MP_0011922 abnormal circulating osteocalcin level http://purl.obolibrary.org/obo/MP_0005418 abnormal circulating hormone level aberrant concentration in the blood of this hormone secreted by osteoblasts which are found in bone and dentin http://purl.obolibrary.org/obo/MP_0011923 abnormal bladder urine volume http://purl.obolibrary.org/obo/MP_0010386 abnormal urinary bladder physiology any anomaly in the amount of space occupied by urine in the bladder http://purl.obolibrary.org/obo/MP_0011924 abnormal liver zinc level http://purl.obolibrary.org/obo/MP_0009615 abnormal zinc homeostasis anomaly in the amount of zinc present in the liver tissue http://purl.obolibrary.org/obo/MP_0011925 abnormal heart echocardiography feature http://purl.obolibrary.org/obo/MP_0001544 abnormal cardiovascular system physiology any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features http://purl.obolibrary.org/obo/MP_0011927 abnormal cardiac valve flow http://purl.obolibrary.org/obo/MP_0011926 abnormal cardiac valve physiology any anomaly of the regulated one-way movement of blood through the heart valves http://purl.obolibrary.org/obo/MP_0011928 abnormal mitral valve flow http://purl.obolibrary.org/obo/MP_0011927 abnormal cardiac valve flow abnormality of valve function causing passive filling of the left ventricle or active filling of the left atrium http://purl.obolibrary.org/obo/MP_0011929 abnormal aortic valve flow http://purl.obolibrary.org/obo/MP_0011927 abnormal cardiac valve flow abnormality impeding normal blood flow or allowing blood to backflow through this valve into the left ventricle http://purl.obolibrary.org/obo/MP_0011930 abnormal tricuspid valve flow http://purl.obolibrary.org/obo/MP_0011927 abnormal cardiac valve flow abnormality of valve function causing passive filling of the right ventricle or active filling of the right atrium http://purl.obolibrary.org/obo/MP_0011931 abnormal pulmonary valve flow http://purl.obolibrary.org/obo/MP_0011927 abnormal cardiac valve flow abnormality impeding normal blood flow or allowing blood to backflow through this valve into the right ventricle http://purl.obolibrary.org/obo/MP_0011933 abnormal exocrine pancreas development http://purl.obolibrary.org/obo/MP_0003934 abnormal pancreas development anomaly in the formation of the acinar gland portion of the pancreas that secretes digestive enzymes http://purl.obolibrary.org/obo/MP_0011934 abnormal branching involved in pancreas development http://purl.obolibrary.org/obo/MP_0003934 abnormal pancreas development any anomaly in the process in which the branches of the developing pancreas are generated and organized http://purl.obolibrary.org/obo/MP_0011935 abnormal pancreatic bud formation http://purl.obolibrary.org/obo/MP_0011934 abnormal branching involved in pancreas development any anomaly in the process in which the foregut region specified to become the pancreas forms a bud http://purl.obolibrary.org/obo/MP_0011936 abnormal PP interval http://purl.obolibrary.org/obo/MP_0010508 abnormal heart electrocardiography waveform feature any anomaly in the distance between consecutive P waves in the electrocardiogram, representing the length of the cardiac cycle; this value is often used in calculating heart rate and heart rate variability http://purl.obolibrary.org/obo/MP_0011937 shortened PP interval http://purl.obolibrary.org/obo/MP_0011936 abnormal PP interval decrease in the distance between consecutive P waves in the electrocardiogram, representing the length of the cardiac cycle http://purl.obolibrary.org/obo/MP_0011938 prolonged PP interval http://purl.obolibrary.org/obo/MP_0011936 abnormal PP interval increase in the distance between consecutive P waves in the electrocardiogram, representing the length of the cardiac cycle http://purl.obolibrary.org/obo/MP_0011940 decreased food intake http://purl.obolibrary.org/obo/MP_0005449 abnormal food intake reduction in the total number of calories/food amount taken in over time when compared to the normal state http://purl.obolibrary.org/obo/MP_0011943 abnormal circadian feeding behavior http://purl.obolibrary.org/obo/MP_0001431 abnormal eating behavior anomaly in the fluctuation pattern in feeding behavior (amount and instances) that occurs over an approximately 24 hour light/dark cycle http://purl.obolibrary.org/obo/MP_0011944 abnormal eating frequency http://purl.obolibrary.org/obo/MP_0001431 abnormal eating behavior anomaly in the number of discrete instances of initiation of eating over time, regardless of amount eaten http://purl.obolibrary.org/obo/MP_0011945 increased eating frequency http://purl.obolibrary.org/obo/MP_0011944 abnormal eating frequency increase in the number of discrete instances of initiation of eating over time, regardless of amount eaten http://purl.obolibrary.org/obo/MP_0011946 decreased eating frequency http://purl.obolibrary.org/obo/MP_0011944 abnormal eating frequency reduction in the number of discrete instances of initiation of eating over time, regardless of amount eaten http://purl.obolibrary.org/obo/MP_0011947 abnormal fluid intake http://purl.obolibrary.org/obo/MP_0001422 abnormal drinking behavior significant anomaly in the total amount of fluid taken in over time when compared to the normal state http://purl.obolibrary.org/obo/MP_0011948 abnormal drinking frequency http://purl.obolibrary.org/obo/MP_0001422 abnormal drinking behavior anomaly in the number of discrete instances of initiation of drinking over time, regardless of amount ingested http://purl.obolibrary.org/obo/MP_0011949 increased drinking frequency http://purl.obolibrary.org/obo/MP_0011948 abnormal drinking frequency increase in the number of discrete instances of initiation of drinking over time, regardless of amount ingested http://purl.obolibrary.org/obo/MP_0011950 decreased drinking frequency http://purl.obolibrary.org/obo/MP_0011948 abnormal drinking frequency reduction in the number of discrete instances of initiation of drinking over time, regardless of amount ingested http://purl.obolibrary.org/obo/MP_0011951 increased cardiac stroke volume http://purl.obolibrary.org/obo/MP_0000304 abnormal cardiac stroke volume increase in the volume of blood pushed into the aorta with each beat of the heart http://purl.obolibrary.org/obo/MP_0011952 decreased cardiac stroke volume http://purl.obolibrary.org/obo/MP_0000304 abnormal cardiac stroke volume reduction in the volume of blood pushed into the aorta with each beat of the heart http://purl.obolibrary.org/obo/MP_0011953 prolonged PQ interval http://purl.obolibrary.org/obo/MP_0011918 abnormal PQ interval increase in the length of time between the beginning of atrial depolarization and the end of atrial repolarization (or recovery), measured by the interval from the beginning of the P wave to the end of the Q wave http://purl.obolibrary.org/obo/MP_0011954 shortened PQ interval http://purl.obolibrary.org/obo/MP_0011918 abnormal PQ interval decrease in the length of time between the beginning of atrial depolarization and the end of atrial repolarization (or recovery), measured by the interval from the beginning of the P wave to the end of the Q wave http://purl.obolibrary.org/obo/MP_0011955 phenotypic reversion by gene product interaction http://purl.obolibrary.org/obo/MP_0003171 phenotypic reversion two or more mutant gene products, when existing together in one organism, result in a wild-type phenotype when each independent mutation shows a phenotype http://purl.obolibrary.org/obo/MP_0011956 abnormal compensatory feeding amount http://purl.obolibrary.org/obo/MP_0001431 abnormal eating behavior anomaly in the amount of food consumed after a period of fasting http://purl.obolibrary.org/obo/MP_0011957 decreased compensatory feeding amount http://purl.obolibrary.org/obo/MP_0011956 abnormal compensatory feeding amount decreased amount of food consumed after a period of fasting http://purl.obolibrary.org/obo/MP_0011958 increased compensatory feeding amount http://purl.obolibrary.org/obo/MP_0011956 abnormal compensatory feeding amount increased amount of food consumed after a period of fasting http://purl.obolibrary.org/obo/MP_0011959 abnormal eye posterior chamber depth http://purl.obolibrary.org/obo/MP_0005299 abnormal eye posterior chamber morphology anomaly in the distance between the iris and the lens at the center plane (maximum distance) of the posterior chamber, compared to controls http://purl.obolibrary.org/obo/MP_0011960 abnormal eye anterior chamber depth http://purl.obolibrary.org/obo/MP_0005205 abnormal eye anterior chamber morphology anomaly in the distance between the iris and the cornea at the center plane (maximum distance) of the anterior chamber, compared to controls http://purl.obolibrary.org/obo/MP_0011962 increased cornea thickness http://purl.obolibrary.org/obo/MP_0011961 abnormal cornea thickness increased width of the cornea in the center plane http://purl.obolibrary.org/obo/MP_0011963 abnormal total retina thickness http://purl.obolibrary.org/obo/MP_0001325 abnormal retina morphology increased or decreased width of the retina through the center plane http://purl.obolibrary.org/obo/MP_0011964 increased total retina thickness http://purl.obolibrary.org/obo/MP_0011963 abnormal total retina thickness increased width of the retina through the center plane http://purl.obolibrary.org/obo/MP_0011965 decreased total retina thickness http://purl.obolibrary.org/obo/MP_0011963 abnormal total retina thickness decreased width of the retina through the center plane http://purl.obolibrary.org/obo/MP_0011966 abnormal auditory brainstem response waveform shape http://purl.obolibrary.org/obo/MP_0004738 abnormal auditory brainstem response any anomaly in the characteristic pattern of electrical activity recording of a series of vertex positive waves generated by neurons in the ascending auditory system, that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts http://purl.obolibrary.org/obo/MP_0011967 increased or absent threshold for auditory brainstem response http://purl.obolibrary.org/obo/MP_0004738 abnormal auditory brainstem response increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click http://purl.obolibrary.org/obo/MP_0011968 decreased threshold for auditory brainstem response http://purl.obolibrary.org/obo/MP_0004738 abnormal auditory brainstem response reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system http://purl.obolibrary.org/obo/MP_0011970 abnormal circulating lactate dehydrogenase level http://purl.obolibrary.org/obo/MP_0002943 abnormal lactate dehydrogenase level abnormal blood level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate; measurements of circulating levels are used clinically as a diagnostic indicator of tissue breakdown, some forms of cancer or particular infection types http://purl.obolibrary.org/obo/MP_0011971 increased circulating lactate dehydrogenase level http://purl.obolibrary.org/obo/MP_0011970 abnormal circulating lactate dehydrogenase level elevated blood level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate; measurements of circulating levels are used clinically as a diagnostic indicator of tissue breakdown, some forms of cancer or particular infection types http://purl.obolibrary.org/obo/MP_0011972 decreased circulating lactate dehydrogenase level http://purl.obolibrary.org/obo/MP_0011970 abnormal circulating lactate dehydrogenase level reduced blood level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate; measurements of circulating levels are used clinically as a diagnostic indicator of tissue breakdown, some forms of cancer or particular infection types http://purl.obolibrary.org/obo/MP_0011974 intestinal stenosis http://purl.obolibrary.org/obo/MP_0000477 abnormal intestine morphology abnormal narrowing or constriction of the segment of the alimentary canal extending from the pyloric sphincter of the stomach to the anus http://purl.obolibrary.org/obo/MP_0011975 neuronal cytoplasmic inclusions http://purl.obolibrary.org/obo/MP_0002882 abnormal neuron morphology presence of aggregates of protein within the cytoplasm of neurons; hallmark of neurodegenerative disorders http://purl.obolibrary.org/obo/MP_0011980 absent Langerhans cell precursors http://purl.obolibrary.org/obo/MP_0008115 abnormal dendritic cell differentiation absence of the yolk sac-derived primitive myeloid progenitors that populate the skin before the onset of fetal liver hematopoiesis http://purl.obolibrary.org/obo/MP_0011981 abnormal microglial cell differentiation http://purl.obolibrary.org/obo/MP_0000136 abnormal microglial cell morphology atypical production of or inability to produce the small, migratory, phagocytic, interstitial cells derived from myeloid progenitor cells and found in the parenchyma of the central nervous system http://purl.obolibrary.org/obo/MP_0011982 decreased microglial cell number http://purl.obolibrary.org/obo/MP_0000136 abnormal microglial cell morphology reduced number of the small, migratory, phagocytic, interstitial cells derived from myeloid progenitor cells and found in the parenchyma of the central nervous system http://purl.obolibrary.org/obo/MP_0011983 abnormal Ito cell differentiation http://purl.obolibrary.org/obo/MP_0008990 abnormal Ito cell morphology atypical production of or inability to produce the fat-storing cells that line the hepatic sinusoids http://purl.obolibrary.org/obo/MP_0011984 decreased enteroendocrine cell number http://purl.obolibrary.org/obo/MP_0004141 abnormal enteroendocrine cell morphology reduction in the number of the various hormone- or neurotransmitter-secreting epithelial cells present throughout the mucosa of the digestive tract http://purl.obolibrary.org/obo/MP_0011985 abnormal macrophage proliferation http://purl.obolibrary.org/obo/MP_0002451 abnormal macrophage physiology anomaly in the ability of macrophages to undergo expansion by cell division; macrophages are large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells http://purl.obolibrary.org/obo/MP_0011986 decreased macrophage proliferation http://purl.obolibrary.org/obo/MP_0011985 abnormal macrophage proliferation reduced ability of macrophages to undergo expansion by cell division; macrophages are large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells http://purl.obolibrary.org/obo/MP_0011987 abnormal GABAergic neuron physiology http://purl.obolibrary.org/obo/MP_0004811 abnormal neuron physiology any functional anomaly of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter http://purl.obolibrary.org/obo/MP_0011988 increased mating frequency http://purl.obolibrary.org/obo/MP_0001377 abnormal mating frequency increased number of attempts of sexual behavioral contact between an initiating organism and a receptive partner http://purl.obolibrary.org/obo/MP_0011990 decreased porphyrin level http://purl.obolibrary.org/obo/MP_0011989 abnormal porphyrin level reduced concentration of porphyrins or protoporphyrins http://purl.obolibrary.org/obo/MP_0011991 aortic cartilaginous metaplasia http://purl.obolibrary.org/obo/MP_0000272 abnormal aorta morphology transformation of cells comprising the aorta epithelium to arterial chondrocytes that express type II collagen, resulting in heterotopic formation of cartilage and may lead to calcification in the aorta http://purl.obolibrary.org/obo/MP_0011992 increased erythrocyte catalase activity http://purl.obolibrary.org/obo/MP_0011593 increased catalase activity greater capacity to catalyze the reaction: 2 hydrogen peroxide = O2 + 2 H2O, in erythorcytes http://purl.obolibrary.org/obo/MP_0011993 increased foot pad temperature http://purl.obolibrary.org/obo/MP_0005533 increased body temperature increased degree of heat natural to the foot pad-environment interface of a living being http://purl.obolibrary.org/obo/MP_0011994 increased nerve conduction velocity http://purl.obolibrary.org/obo/MP_0005403 abnormal nerve conduction increase in the rate at which an electrical impulse travels through a nerve http://purl.obolibrary.org/obo/MP_0011995 decreased leukemia incidence http://purl.obolibrary.org/obo/MP_0010283 decreased classified tumor incidence less than the expected number of neoplasms derived from blood or bone marrow in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0011998 decreased embryonic cilium length http://purl.obolibrary.org/obo/MP_0004131 abnormal motile primary cilium morphology reduced length of the cilia of the mouse embryo found on the cells of the embryonic node http://purl.obolibrary.org/obo/MP_0012000 abnormal limb position http://purl.obolibrary.org/obo/MP_0002109 abnormal limb morphology anomaly in the location of the limbs on the body relative to other body parts or axes http://purl.obolibrary.org/obo/MP_0012001 abnormal touch escape response http://purl.obolibrary.org/obo/MP_0002067 abnormal sensory capabilities/reflexes/nociception anomaly in the ability of an animal to respond to the approach of a human hand by fleeing from it http://purl.obolibrary.org/obo/MP_0012002 impaired touch escape response http://purl.obolibrary.org/obo/MP_0012001 abnormal touch escape response impaired ability of an animal to respond to the approach of a human hand by fleeing from it, including fleeing only after a touch or stroke, or not responding to touch by fleeing http://purl.obolibrary.org/obo/MP_0012003 abnormal septum of telencephalon morphology http://purl.obolibrary.org/obo/MP_0000787 abnormal telencephalon morphology any structural anomaly of the gray matter structures of the telencephalon and limbic system in the brain; included is the cortical septal area, subcortical septal nuclei, and the septum pellucidum; however, many authorities consider the septal region to be made up of the septal area and the septal nuclei, but excluding the septum pellucidum http://purl.obolibrary.org/obo/MP_0012004 abnormal septum pellucidum morphology http://purl.obolibrary.org/obo/MP_0012003 abnormal septum of telencephalon morphology any structural anomaly of the thin, triangular, vertical membrane separating the anterior horns of the left and right lateral ventricles of the septum, which has strong projections to hypothalamic and midbrain regions and receives projections from the hippocampus and amygdala http://purl.obolibrary.org/obo/MP_0012005 abnormal septum pellucidum size http://purl.obolibrary.org/obo/MP_0012004 abnormal septum pellucidum morphology anomaly in the size of the thin, triangular, vertical membrane separating the anterior horns of the left and righ of the septum, which has strong projections to hypothalamic and midbrain regions and receives projections from the hippocampus and amygdala http://purl.obolibrary.org/obo/MP_0012006 abnormal hippocampus physiology http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology any functional anomaly related to processes in the deep lying structure of the cerebrum involved with memory storage and spatial navigation http://purl.obolibrary.org/obo/MP_0012008 delayed parturition http://purl.obolibrary.org/obo/MP_0002907 abnormal parturition the process of labor and delivery in female animals occurs later in gestation than expected or lack of progress in a labor already initiated http://purl.obolibrary.org/obo/MP_0012009 early parturition http://purl.obolibrary.org/obo/MP_0002907 abnormal parturition the process of labor and delivery in female animals occurs earlier in gestation than expected http://purl.obolibrary.org/obo/MP_0012010 parturition failure http://purl.obolibrary.org/obo/MP_0002907 abnormal parturition the process of labor and delivery in female animals does not initiate or complete http://purl.obolibrary.org/obo/MP_0012011 febrile seizures http://purl.obolibrary.org/obo/MP_0002064 seizures a convulsion associated with a significant rise in body temperature (fever) http://purl.obolibrary.org/obo/MP_0012012 abnormal innate olfactory avoidance response http://purl.obolibrary.org/obo/MP_0012013 abnormal innate avoidance response any anomaly in the naive behavioral response of an individual to an aversive olfactory stimulus, in which the tendency to act defensively is stronger than the tendency to attack http://purl.obolibrary.org/obo/MP_0012013 abnormal innate avoidance response http://purl.obolibrary.org/obo/MP_0002572 abnormal emotion/affect behavior any anomaly in the naive behavioral response of an individual to an aversive stimulus, in which the tendency to act defensively is stronger than the tendency to attack http://purl.obolibrary.org/obo/MP_0012014 abnormal olfactory neuron innervation pattern http://purl.obolibrary.org/obo/MP_0000968 abnormal sensory neuron innervation pattern any changes in the placement, morphology or number of axons from olfactory neurons to an effector tissue or to olfactory glomeruli or olfactory bulb http://purl.obolibrary.org/obo/MP_0012015 abnormal eumelanosome eumelanin content http://purl.obolibrary.org/obo/MP_0013314 abnormal eumelanosome morphology anomaly in the amount or distribution of black (or brown) pigment in the eumelanosomes of melanocytes http://purl.obolibrary.org/obo/MP_0012016 abnormal hair follicle eumelanosome eumelanin content http://purl.obolibrary.org/obo/MP_0012015 abnormal eumelanosome eumelanin content anomaly in the amount or distribution of black (or brown) pigment in the eumelanosomes of the hair follicle melanocytes http://purl.obolibrary.org/obo/MP_0012017 grizzled coat color http://purl.obolibrary.org/obo/MP_0002075 abnormal coat/hair pigmentation amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreased compared to wild-type agouti producing hair that is partly gray or streaked with gray http://purl.obolibrary.org/obo/MP_0012019 abnormal oviduct epithelium motile cilium physiology http://purl.obolibrary.org/obo/MP_0013209 abnormal motile cilium physiology any functional anomaly of the multiple epithelial tiny, motile hair-like projections, which have a variable arrangement of axonemal microtubules, contains molecular motors, and beat with a characteristic whip-like pattern that promote transport of fluids and other cells across the epithelium of the oviduct http://purl.obolibrary.org/obo/MP_0012020 abnormal olfactory epithelium physiology http://purl.obolibrary.org/obo/MP_0001983 abnormal olfactory system physiology any functional anomaly in the epithelial cells that line the interior of the nose http://purl.obolibrary.org/obo/MP_0012021 abnormal melanocyte number http://purl.obolibrary.org/obo/MP_0002877 abnormal melanocyte morphology deviation from the average number of the cells that produce pigment http://purl.obolibrary.org/obo/MP_0012022 increased melanocyte number http://purl.obolibrary.org/obo/MP_0012021 abnormal melanocyte number greater number of the cells that produce pigment http://purl.obolibrary.org/obo/MP_0012023 decreased melanocyte number http://purl.obolibrary.org/obo/MP_0012021 abnormal melanocyte number reduced number of the cells that produce pigment http://purl.obolibrary.org/obo/MP_0012024 abnormal nephron morphogenesis http://purl.obolibrary.org/obo/MP_0003881 abnormal nephron morphology any anomaly in the process in which the nephron is generated and organized; the nephron is the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of Henle http://purl.obolibrary.org/obo/MP_0012025 abnormal comma shaped body morphology http://purl.obolibrary.org/obo/MP_0012024 abnormal nephron morphogenesis any structural anomaly of precursor structure to the S-shaped body that contributes to the morphogenesis of the nephron http://purl.obolibrary.org/obo/MP_0012026 abnormal S-shaped body morphology http://purl.obolibrary.org/obo/MP_0012024 abnormal nephron morphogenesis any structural anomaly of the successor of the comma-shaped body that contributes to the morphogenesis of the nephron http://purl.obolibrary.org/obo/MP_0012027 abnormal embryonic cilium location or orientation http://purl.obolibrary.org/obo/MP_0004131 abnormal motile primary cilium morphology embryonic cilia are displaced from the normal position and/or do not orient in a typical pattern http://purl.obolibrary.org/obo/MP_0012029 abnormal electroretinogram waveform feature http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology any anomaly in the pattern of the graphic record of the integrated ensemble response from many vision related neuronal and glial populations as a consequence of the serial processing within the retina, represented as changes in voltage over time after visual photonic stimulation http://purl.obolibrary.org/obo/MP_0012030 abnormal a wave amplitude http://purl.obolibrary.org/obo/MP_0012034 abnormal a wave shape anomaly in the size (height or maximum displacement) of the a wave as measured in the electroretinogram http://purl.obolibrary.org/obo/MP_0012031 abnormal b wave amplitude http://purl.obolibrary.org/obo/MP_0012035 abnormal b-wave shape anomaly in the size (height or maximum displacement) of the b wave as measured in the electroretinogram http://purl.obolibrary.org/obo/MP_0012032 abnormal ERG latency http://purl.obolibrary.org/obo/MP_0012029 abnormal electroretinogram waveform feature anomaly in the time from onset of stimulus to beginning of a waveform feature http://purl.obolibrary.org/obo/MP_0012033 abnormal ERG implicit time http://purl.obolibrary.org/obo/MP_0012029 abnormal electroretinogram waveform feature anomaly in the time from the onset of light stimulus to the peak of a waveform feature http://purl.obolibrary.org/obo/MP_0012034 abnormal a wave shape http://purl.obolibrary.org/obo/MP_0012029 abnormal electroretinogram waveform feature any anomaly in the graphical representation of the a wave in the electroretinogram; the a wave represents the general physiological health of the photoreceptors in the outer retina http://purl.obolibrary.org/obo/MP_0012035 abnormal b-wave shape http://purl.obolibrary.org/obo/MP_0012029 abnormal electroretinogram waveform feature any anomaly in the graphical representation of the b wave in the electroretinogram; the b wave represents the health of the inner layers of the retina, including the ON bipolar cells and the Muller cells http://purl.obolibrary.org/obo/MP_0012036 abnormal a wave latency http://purl.obolibrary.org/obo/MP_0012032 abnormal ERG latency anomaly in the time from onset of stimulus to beginning of the a wave http://purl.obolibrary.org/obo/MP_0012037 abnormal b wave latency http://purl.obolibrary.org/obo/MP_0012032 abnormal ERG latency anomaly in the time from onset of stimulus to beginning of the b wave http://purl.obolibrary.org/obo/MP_0012038 abnormal a wave implicit time http://purl.obolibrary.org/obo/MP_0012033 abnormal ERG implicit time anomaly in the time from the onset of light stimulus to the peak of the a wave http://purl.obolibrary.org/obo/MP_0012039 abnormal b wave implicit time http://purl.obolibrary.org/obo/MP_0012033 abnormal ERG implicit time anomaly in the time from the onset of light stimulus to the peak of the b wave http://purl.obolibrary.org/obo/MP_0012040 abnormal c wave shape http://purl.obolibrary.org/obo/MP_0012029 abnormal electroretinogram waveform feature any anomaly in the graphical representation of the c wave in the electroretinogram; the ERG c-wave can be used to assess the functional integrity of the photoreceptors, the pigment epithelial cells and the interactions between them. http://purl.obolibrary.org/obo/MP_0012041 susceptible to pulmonary hyaline membrane formation http://purl.obolibrary.org/obo/MP_0011018 pulmonary hyaline membrane formation increased likelihood of the presence of an eosinophilic hyaline (glass-like) material composed of fibrin, proteinaceous exudate and cellular debris, and lining or filling the alveoli, alveolar ducts and bronchioles http://purl.obolibrary.org/obo/MP_0012042 low alcohol preference http://purl.obolibrary.org/obo/MP_0001425 abnormal alcohol consumption decreased predilection to ingest alcohol over other substances http://purl.obolibrary.org/obo/MP_0012043 increased myoepithelioma incidence http://purl.obolibrary.org/obo/MP_0010273 increased classified tumor incidence greater than the expected occurrence of a benign tumor of myoepithelial cells, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0012044 abnormal phospholipase A2 level http://purl.obolibrary.org/obo/MP_0008469 abnormal protein level anomaly in the amount of any of the enzymes that release fatty acids from the second carbon group of glycerol http://purl.obolibrary.org/obo/MP_0012045 increased susceptibility to hypertension http://purl.obolibrary.org/obo/MP_0000231 hypertension more likely than normal to develop sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states http://purl.obolibrary.org/obo/MP_0012046 decreased susceptibility to hypertension http://purl.obolibrary.org/obo/MP_0000231 hypertension less likely than normal to develop sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states http://purl.obolibrary.org/obo/MP_0012047 abnormal cholinesterase level http://purl.obolibrary.org/obo/MP_0008469 abnormal protein level anomaly in the amount of any of the enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid http://purl.obolibrary.org/obo/MP_0012048 altered response to retinal ischemic injury http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology altered response to lack of adequate blood flow, due to trauma or disease, to support the normal functioning of the retina http://purl.obolibrary.org/obo/MP_0012049 increased susceptilbility to retinal ischemic injury http://purl.obolibrary.org/obo/MP_0012048 altered response to retinal ischemic injury increased frequency or more severe response, such as necrotic tissue size, to lack of adequate blood flow, due to trauma or disease, to support the normal functioning of the retina http://purl.obolibrary.org/obo/MP_0012050 decreased susceptilbility to retinal ischemic injury http://purl.obolibrary.org/obo/MP_0012048 altered response to retinal ischemic injury decreased frequency or less severe response, such as necrotic tissue size, to lack of adequate blood flow, due to trauma or disease, to support the normal functioning of the retina http://purl.obolibrary.org/obo/MP_0012051 spasticity http://purl.obolibrary.org/obo/MP_0003491 abnormal voluntary movement a motor disorder characterized by a velocity-dependent increase in tonic stretch reflexes with increased muscle tone, exaggerated (hyperexcitable) tendon reflexes and increased resistance to stretch http://purl.obolibrary.org/obo/MP_0012052 hypertonicity http://purl.obolibrary.org/obo/MP_0012051 spasticity abnormally increased muscle tone or strength that impairs proper movement http://purl.obolibrary.org/obo/MP_0012053 limb hypertonicity http://purl.obolibrary.org/obo/MP_0012052 hypertonicity limbs exhibit abnormally increased muscle tone; can be due to muscle genetic defects or some CNS disorders and may be evident in arm or leg deformities http://purl.obolibrary.org/obo/MP_0012054 abnormal phrenic nerve innervation pattern http://purl.obolibrary.org/obo/MP_0002184 abnormal innervation any changes in the placement, morphology or number of phrenic nerve fibers providing motor supply to the diaphragm as well as sensory fibers to the central tendon, or in the thorax, phrenic nerve sensory fibers to the mediastinal pleura and pericardium http://purl.obolibrary.org/obo/MP_0012055 abnormal phrenic nerve innervation pattern to diaphragm http://purl.obolibrary.org/obo/MP_0012054 abnormal phrenic nerve innervation pattern any changes in the placement, morphology or number of the portion of phrenic nerve fibers providing motor supply to the diaphragm http://purl.obolibrary.org/obo/MP_0012058 abnormal morula morphology http://purl.obolibrary.org/obo/MP_0009781 abnormal preimplantation embryo development any structural anomaly of the globular solid mass of blastomeres formed by cleavage of a zygote that typically precedes the blastula, typically after the zygote has divided into 32 cells http://purl.obolibrary.org/obo/MP_0012059 thick diaphragm muscle http://purl.obolibrary.org/obo/MP_0002279 abnormal diaphragm morphology increased thickness of the diaphragm muscle http://purl.obolibrary.org/obo/MP_0012061 abnormal central tendon morphology http://purl.obolibrary.org/obo/MP_0005503 abnormal tendon morphology any structural anomaly of the three-lobed cloverleaf-shaped aponeurosis situated at the center of the diaphragm; the central tendon is fused with the fibrous pericardium that provides attachment for the muscle fibers http://purl.obolibrary.org/obo/MP_0012062 small tail bud http://purl.obolibrary.org/obo/MP_0002861 abnormal tail bud morphology decreased size or area of the primordial region of the embryo that arises to form the tail of the adult http://purl.obolibrary.org/obo/MP_0012063 absent tail bud http://purl.obolibrary.org/obo/MP_0002861 abnormal tail bud morphology missing the primordial region of the embryo that arises to form the tail of the adult http://purl.obolibrary.org/obo/MP_0012064 abnormal astrocyte number http://purl.obolibrary.org/obo/MP_0002182 abnormal astrocyte morphology anomaly in the number of the large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord http://purl.obolibrary.org/obo/MP_0012066 decreased astrocyte number http://purl.obolibrary.org/obo/MP_0012064 abnormal astrocyte number reduction in the number of the large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord http://purl.obolibrary.org/obo/MP_0012067 abnormal olfactory gland morphology http://purl.obolibrary.org/obo/MP_0005499 abnormal olfactory system morphology any structural anomaly of the Bowman's glands (aka glands of Bowman, olfactory glands), situated in the olfactory mucosa, beneath the olfactory epithelium, in the lamina propria, a connective tissue also containing fibroblasts, blood vessels, and bundles of fine axons from the olfactory neurons; Bowman's glands consists of an acinus in the lamina propria and a secretory duct going out through the olfactory epithelium http://purl.obolibrary.org/obo/MP_0012068 abnormal globose cell of olfactory epithelium morphology http://purl.obolibrary.org/obo/MP_0008789 abnormal olfactory epithelium morphology any structural anomaly of the rounded or elliptical epithelial cells, with pale-staining open face nucleus and pale cytoplasm rich in free ribosomes and clusters of centrioles, that form a distinct basal zone spaced slightly from the basal surface of the olfactory epithelium http://purl.obolibrary.org/obo/MP_0012069 abnormal horizontal basal cell morphology http://purl.obolibrary.org/obo/MP_0008789 abnormal olfactory epithelium morphology any structural anomaly of the flat or angular epithelial cell with condensed nuclei and darkly staining cytoplasm containing numerous intermediate filaments inserted into desmosomes contacting surrounding supporting cells, that lie in contact with the basal lamina of olfactory epithelium http://purl.obolibrary.org/obo/MP_0012070 altered susceptibility to osteoporosis http://purl.obolibrary.org/obo/MP_0003795 abnormal bone structure a change in the likelihood that an organism will develop a reduction in bone mass or atrophy of skeletal tissue, usually accompanied by gross changes to bone matrix, leading to bone fragility http://purl.obolibrary.org/obo/MP_0012071 increased susceptibility to osteoporosis http://purl.obolibrary.org/obo/MP_0012070 altered susceptibility to osteoporosis greater likelihood that an organism will develop a reduction in bone mass or atrophy of skeletal tissue, usually accompanied by gross changes to bone matrix, leading to bone fragility http://purl.obolibrary.org/obo/MP_0012072 decreased susceptibility to osteoporosis http://purl.obolibrary.org/obo/MP_0012070 altered susceptibility to osteoporosis reduced likelihood that an organism will develop a reduction in bone mass or atrophy of skeletal tissue, usually accompanied by gross changes to bone matrix, leading to bone fragility http://purl.obolibrary.org/obo/MP_0012073 premature mammary gland growth during pregnancy http://purl.obolibrary.org/obo/MP_0006269 abnormal mammary gland growth during pregnancy faster progression of the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation in preparation for lactation http://purl.obolibrary.org/obo/MP_0012074 failure of mammary gland growth during pregnancy http://purl.obolibrary.org/obo/MP_0012075 impaired mammary gland growth during pregnancy arrest, or failure ti initiate the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation in preparation for lactation http://purl.obolibrary.org/obo/MP_0012075 impaired mammary gland growth during pregnancy http://purl.obolibrary.org/obo/MP_0006269 abnormal mammary gland growth during pregnancy defect in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation in preparation for lactation http://purl.obolibrary.org/obo/MP_0012077 webbed neck http://purl.obolibrary.org/obo/MP_0012719 abnormal neck morphology the skin on the neck appears as loose folds that develop a web-like appearance from the ears to the shoulder during growth and maturation http://purl.obolibrary.org/obo/MP_0012078 abnormal tail ring morphology http://purl.obolibrary.org/obo/MP_0001191 abnormal skin condition any structural anomaly of the segmentally patterned skin ridges appearing on the tail of rodents http://purl.obolibrary.org/obo/MP_0012080 chylous ascites http://purl.obolibrary.org/obo/MP_0005324 ascites the extravasation of milky triglyceride-rich chyle into the peritoneal cavity; often a secondary symptom of neoplasms http://purl.obolibrary.org/obo/MP_0012081 absent heart tube http://purl.obolibrary.org/obo/MP_0000270 abnormal heart tube morphology absence of the primitive epithelial cardiac tube before the division into the chambers of the mature heart http://purl.obolibrary.org/obo/MP_0012082 delayed heart development http://purl.obolibrary.org/obo/MP_0000267 abnormal heart development late onset of the induction and/or differentiation of the heart http://purl.obolibrary.org/obo/MP_0012083 absent foregut http://purl.obolibrary.org/obo/MP_0000474 abnormal foregut morphology absence of the anterior portion of the primitive digestive tube of the embryo that lies cephalic to the junction of the yolk stalk, consists of endodermal tissue, and gives rise to the pharynx, lower respiratory system, esophagus, stomach, duodenum proximal to the biliary tract, liver, pancreas, biliary tract, and gall bladder http://purl.obolibrary.org/obo/MP_0012084 truncated foregut http://purl.obolibrary.org/obo/MP_0000474 abnormal foregut morphology shortened foregut that terminates abruptly as if having an end or point cut off http://purl.obolibrary.org/obo/MP_0012085 midface hypoplasia http://purl.obolibrary.org/obo/MP_0003743 abnormal facial morphology underdevelopment of the midfacial region comprising the nasal, maxillary, and zygomatic bones, leading to a concave-looking face http://purl.obolibrary.org/obo/MP_0012086 absent hindgut http://purl.obolibrary.org/obo/MP_0008786 abnormal hindgut morphology absence of the caudal portion of the primitive digestive tube of the embryo http://purl.obolibrary.org/obo/MP_0012087 absent midbrain http://purl.obolibrary.org/obo/MP_0000897 abnormal midbrain morphology absence of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes http://purl.obolibrary.org/obo/MP_0012088 abnormal midbrain size http://purl.obolibrary.org/obo/MP_0000897 abnormal midbrain morphology deviation from the average range of midbrain size compared to normal http://purl.obolibrary.org/obo/MP_0012089 decreased midbrain size http://purl.obolibrary.org/obo/MP_0012088 abnormal midbrain size size reduction or truncation of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes http://purl.obolibrary.org/obo/MP_0012090 midbrain hypoplasia http://purl.obolibrary.org/obo/MP_0012089 decreased midbrain size underdevelopment or reduced size, usually due to a reduced number of cells, of the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes http://purl.obolibrary.org/obo/MP_0012092 diencephalon hypoplasia http://purl.obolibrary.org/obo/MP_0000830 abnormal diencephalon morphology underdevelopment or decreased size, usually due an increased number of cells in the rostral portion of the brain stem http://purl.obolibrary.org/obo/MP_0012093 absent nodal flow http://purl.obolibrary.org/obo/MP_0008933 abnormal motile primary cilium physiology absence of the leftward movement of extra-embryonic fluid at the ventral node; nodal flow is autonomously generated by the rotation of cilia that are tilted toward the posterior on cells of the ventral node and is the central process in symmetry breaking on the left-right axis; when nodal cilia are immotile or absent, nodal flow does not occur http://purl.obolibrary.org/obo/MP_0012094 abnormal Reichert's membrane thickness http://purl.obolibrary.org/obo/MP_0003954 abnormal Reichert's membrane morphology anomaly in the width of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm during placenta morphogenesis and is secreted by the distal parietal endoderm http://purl.obolibrary.org/obo/MP_0012095 increased Reichert's membrane thickness http://purl.obolibrary.org/obo/MP_0012094 abnormal Reichert's membrane thickness increased width of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm during placenta morphogenesis and is secreted by the distal parietal endoderm http://purl.obolibrary.org/obo/MP_0012096 decreased Reichert's membrane thickness http://purl.obolibrary.org/obo/MP_0012094 abnormal Reichert's membrane thickness reduced width of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm during placenta morphogenesis and is secreted by the distal parietal endoderm http://purl.obolibrary.org/obo/MP_0012097 abnormal spongiotrophoblast size http://purl.obolibrary.org/obo/MP_0004255 abnormal spongiotrophoblast layer morphology anomaly in the size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors http://purl.obolibrary.org/obo/MP_0012098 increased spongiotrophoblast size http://purl.obolibrary.org/obo/MP_0012097 abnormal spongiotrophoblast size greater size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors http://purl.obolibrary.org/obo/MP_0012099 decreased spongiotrophoblast size http://purl.obolibrary.org/obo/MP_0012097 abnormal spongiotrophoblast size reduction of the size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors http://purl.obolibrary.org/obo/MP_0012100 absent spongiotrophoblast http://purl.obolibrary.org/obo/MP_0004255 abnormal spongiotrophoblast layer morphology absence of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors http://purl.obolibrary.org/obo/MP_0012101 acoria http://purl.obolibrary.org/obo/MP_0001317 abnormal pupil morphology absence of the pupil of the eye http://purl.obolibrary.org/obo/MP_0012102 absent trophectoderm http://purl.obolibrary.org/obo/MP_0005028 abnormal trophectoderm morphology absence of the outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo's means of nutrition http://purl.obolibrary.org/obo/MP_0012104 small amniotic cavity http://purl.obolibrary.org/obo/MP_0011199 abnormal amniotic cavity morphology reduced size of the closed space between the embryo and the amnion which contains the amniotic fluid and is formed by the fusion of the parts of the anterior and posterior amniotic folds http://purl.obolibrary.org/obo/MP_0012105 delayed gastrulation http://purl.obolibrary.org/obo/MP_0001695 abnormal gastrulation late onset of the development and invagination of the embryonic germ layers http://purl.obolibrary.org/obo/MP_0012108 increased trophoblast glycogen cell number http://purl.obolibrary.org/obo/MP_0008958 abnormal trophoblast glycogen cell morphology greater number of the glycogen-accumulating trophoblast cells that arise in the junctional zone of the placenta http://purl.obolibrary.org/obo/MP_0012109 decreased trophoblast glycogen cell number http://purl.obolibrary.org/obo/MP_0008958 abnormal trophoblast glycogen cell morphology reduced number of the glycogen-accumulating trophoblast cells that arise in the junctional zone of the placenta http://purl.obolibrary.org/obo/MP_0012110 increased hair follicle number http://purl.obolibrary.org/obo/MP_0000377 abnormal hair follicle morphology greater number of the epidermal invaginations from which the hair shaft develops http://purl.obolibrary.org/obo/MP_0012111 failure of morula compaction http://purl.obolibrary.org/obo/MP_0008932 abnormal embryonic tissue physiology inability to initiate or maintain the first cell differentiation event in mammalian development, occurring at the late eight-cell stage in the mouse, whereby cells on the outer part of the morula become flattened and bound tightly together with the formation of desmosomes and gap junctions, becoming nearly indistinguishable http://purl.obolibrary.org/obo/MP_0012119 increased trophectoderm apoptosis http://purl.obolibrary.org/obo/MP_0004264 abnormal extraembryonic tissue physiology increase in the number of trophectoderm cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0012120 trophectoderm cell degeneration http://purl.obolibrary.org/obo/MP_0004264 abnormal extraembryonic tissue physiology a retrogressive impairment of function or destruction of trophectoderm cells http://purl.obolibrary.org/obo/MP_0012121 sclerocornea http://purl.obolibrary.org/obo/MP_0001314 corneal opacity a congenital anomaly of the eye in which partial or complete corneal opacity is present and resembles the sclera, with no clear boundary between these structures http://purl.obolibrary.org/obo/MP_0012122 abnormal iris transillumination http://purl.obolibrary.org/obo/MP_0001322 abnormal iris morphology any anomaly in the radial light dispersion pattern of the iris when a focused light beam is passed through it; particular dispersion pattern anomalies are indicative of abnormalities in iris pigment distribution and for the presence of glaucoma, atrophy and/or infection http://purl.obolibrary.org/obo/MP_0012123 abnormal bronchoconstrictive response http://purl.obolibrary.org/obo/MP_0002133 abnormal respiratory system physiology anomaly in the expected bronchoconstrictive response to provocation challenge with lipopolysaccharide, bradykinin, histamine or other antigen/allergen or agent, often measured by plethysmography http://purl.obolibrary.org/obo/MP_0012124 increased bronchoconstrictive response http://purl.obolibrary.org/obo/MP_0012123 abnormal bronchoconstrictive response enhanced or greater than expected bronchoconstrictive response to provocation challenge with lipopolysaccharide, bradykinin, histamine or other antigen/allergen or agent, often measured by plethysmography http://purl.obolibrary.org/obo/MP_0012125 decreased bronchoconstrictive response http://purl.obolibrary.org/obo/MP_0012123 abnormal bronchoconstrictive response reduction in the expected bronchoconstrictive response to provocation challenge with lipopolysaccharide, bradykinin, histamine or other antigen/allergen or agent, often measured by plethysmography http://purl.obolibrary.org/obo/MP_0012126 abnormal placenta hemotrichorial membrane morphology http://purl.obolibrary.org/obo/MP_0001711 abnormal placenta morphology any structural anomaly of the three trophoblast cell layers found in rodent placentas between fetal blood vessels and maternal blood sinuses http://purl.obolibrary.org/obo/MP_0012127 absent placenta hemotrichorial membrane http://purl.obolibrary.org/obo/MP_0012126 abnormal placenta hemotrichorial membrane morphology absence of the three trophoblast cell layers found in rodent placentas between fetal blood vessels and maternal blood sinuses http://purl.obolibrary.org/obo/MP_0012128 abnormal blastocyst formation http://purl.obolibrary.org/obo/MP_0004957 abnormal blastocyst morphology atypical formation of a blastocyst from a solid ball of cells known as a morula, including anomalies in the formation of a fluid-filled cavity (blastocoele) and/or initiation of inner cell mass and trophectoderm differentiation http://purl.obolibrary.org/obo/MP_0012129 failure of blastocyst formation http://purl.obolibrary.org/obo/MP_0012128 abnormal blastocyst formation inability to form a blastocyst from a solid ball of cells known as a morula http://purl.obolibrary.org/obo/MP_0012130 abnormal morula formation http://purl.obolibrary.org/obo/MP_0012058 abnormal morula morphology atypical formation of the spherical embryonic mass of blastomeres formed before the blastula and resulting from cleavage of the fertilized ovum http://purl.obolibrary.org/obo/MP_0012131 small visceral yolk sac http://purl.obolibrary.org/obo/MP_0001718 abnormal visceral yolk sac morphology reduced size of the extraembryonic tissue membrane, formed from the visceral endoderm and the extraembryonic mesoderm, which is located ventral to the embryonic disc and is connected to the presumptive midgut of the embryo http://purl.obolibrary.org/obo/MP_0012133 absent midbrain-hindbrain boundary http://purl.obolibrary.org/obo/MP_0012132 abnormal midbrain-hindbrain boundary morphology absence of the midbrain-hindbrain domain of the embryonic brain that is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; normally, an organizing center located at the boundary patterns the midbrain and hindbrain primordia of the neural plate http://purl.obolibrary.org/obo/MP_0012134 absent umbilical cord http://purl.obolibrary.org/obo/MP_0001725 abnormal umbilical cord morphology absence of or failure to form the connective stalk between the fetus and the placenta http://purl.obolibrary.org/obo/MP_0012135 embryonic-extraembryonic boundary constriction http://purl.obolibrary.org/obo/MP_0003890 abnormal embryonic-extraembryonic boundary morphology an invagination or pinching in the visceral endoderm that is centered at the boundary between embryonic and extra-embryonic regions of the developing embryo, often resulting in physical separation of embryonic and extraembryonic ectoderm http://purl.obolibrary.org/obo/MP_0012136 absent forebrain http://purl.obolibrary.org/obo/MP_0000783 abnormal forebrain morphology absence of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions) http://purl.obolibrary.org/obo/MP_0012137 abnormal forebrain size http://purl.obolibrary.org/obo/MP_0000783 abnormal forebrain morphology deviation from the average range of forebrain size compared to normal http://purl.obolibrary.org/obo/MP_0012139 increased forebrain size http://purl.obolibrary.org/obo/MP_0012137 abnormal forebrain size greater than average size of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions) http://purl.obolibrary.org/obo/MP_0012140 forebrain hyperplasia http://purl.obolibrary.org/obo/MP_0012139 increased forebrain size overdevelopment or increased size, usually due to a increased number of cells, of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions) http://purl.obolibrary.org/obo/MP_0012141 absent hindbrain http://purl.obolibrary.org/obo/MP_0000841 abnormal hindbrain morphology absence of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived; the metencephalon (anterior part of the embryonic hindbrain), gives rise to the cerebellum and pons while the myelencephalon (posterior portion of the embryonic hindbrain) gives rise to the medulla oblongata http://purl.obolibrary.org/obo/MP_0012142 absent amniotic cavity http://purl.obolibrary.org/obo/MP_0011199 abnormal amniotic cavity morphology absence of the closed space between the embryo and the amnion which contains the amniotic fluid and is formed by the fusion of the parts of the anterior and posterior amniotic folds http://purl.obolibrary.org/obo/MP_0012143 decreased a wave amplitude http://purl.obolibrary.org/obo/MP_0012030 abnormal a wave amplitude reduction in the size (height or maximum displacement) of the a wave as measured in the electroretinogram http://purl.obolibrary.org/obo/MP_0012144 decreased b wave amplitude http://purl.obolibrary.org/obo/MP_0012031 abnormal b wave amplitude reduction in the size (height or maximum displacement) of the b wave as measured in the electroretinogram http://purl.obolibrary.org/obo/MP_0012145 increased a wave amplitude http://purl.obolibrary.org/obo/MP_0012030 abnormal a wave amplitude increase in the size (height or maximum displacement) of the a wave as measured in the electroretinogram http://purl.obolibrary.org/obo/MP_0012146 increased b wave amplitude http://purl.obolibrary.org/obo/MP_0012031 abnormal b wave amplitude increase in the size (height or maximum displacement) of the b wave as measured in the electroretinogram http://purl.obolibrary.org/obo/MP_0012147 increased a wave implicit time http://purl.obolibrary.org/obo/MP_0012038 abnormal a wave implicit time increase in the time from the onset of light stimulus to the peak of the a wave http://purl.obolibrary.org/obo/MP_0012148 decreased a wave implicit time http://purl.obolibrary.org/obo/MP_0012038 abnormal a wave implicit time decrease in the time from the onset of light stimulus to the peak of the a wave http://purl.obolibrary.org/obo/MP_0012149 decreased b wave implicit time http://purl.obolibrary.org/obo/MP_0012039 abnormal b wave implicit time decrease in the time from the onset of light stimulus to the peak of the b wave http://purl.obolibrary.org/obo/MP_0012150 increased b wave implicit time http://purl.obolibrary.org/obo/MP_0012039 abnormal b wave implicit time increase in the time from the onset of light stimulus to the peak of the b wave http://purl.obolibrary.org/obo/MP_0012151 increased a wave latency http://purl.obolibrary.org/obo/MP_0012036 abnormal a wave latency increase in the time from onset of stimulus to beginning of the a wave http://purl.obolibrary.org/obo/MP_0012152 decreased a wave latency http://purl.obolibrary.org/obo/MP_0012036 abnormal a wave latency decrease in the time from onset of stimulus to beginning of the a wave http://purl.obolibrary.org/obo/MP_0012153 increased b wave latency http://purl.obolibrary.org/obo/MP_0012037 abnormal b wave latency increase in the time from onset of stimulus to beginning of the b wave http://purl.obolibrary.org/obo/MP_0012154 decreased b wave latency http://purl.obolibrary.org/obo/MP_0012037 abnormal b wave latency decrease in the time from onset of stimulus to beginning of the b wave http://purl.obolibrary.org/obo/MP_0012155 abnormal optic pit morphology http://purl.obolibrary.org/obo/MP_0003935 abnormal craniofacial development any structural anomaly of the depression found on each side of the end of the neural ectoderm (or neural tube) of the embryo; the pit deepens to form the optic vesicle http://purl.obolibrary.org/obo/MP_0012156 rostral-caudal axis duplication http://purl.obolibrary.org/obo/MP_0005221 abnormal rostral-caudal axis patterning partial or complete duplication of rostral-caudal axis structures http://purl.obolibrary.org/obo/MP_0012157 rostral body truncation http://purl.obolibrary.org/obo/MP_0005221 abnormal rostral-caudal axis patterning rostral part of body truncated; typically with the caudal portion of the body relatively normal http://purl.obolibrary.org/obo/MP_0012158 absent visceral endoderm http://purl.obolibrary.org/obo/MP_0011186 abnormal visceral endoderm morphology absence of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut http://purl.obolibrary.org/obo/MP_0012159 absent anterior visceral endoderm http://purl.obolibrary.org/obo/MP_0008533 abnormal anterior visceral endoderm morphology absence of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue http://purl.obolibrary.org/obo/MP_0012160 expanded anterior visceral endoderm http://purl.obolibrary.org/obo/MP_0008533 abnormal anterior visceral endoderm morphology the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue occupies a greater area in the extraembryonic region http://purl.obolibrary.org/obo/MP_0012161 absent distal visceral endoderm http://purl.obolibrary.org/obo/MP_0010126 abnormal distal visceral endoderm morphology absence of the precursors of the anterior visceral endoderm that arises at the distal tip of the embryo http://purl.obolibrary.org/obo/MP_0012162 absent parietal endoderm http://purl.obolibrary.org/obo/MP_0011187 abnormal parietal endoderm morphology absence of the primitive endoderm-derived tissue that lines the luminal surface of the mural trophectoderm http://purl.obolibrary.org/obo/MP_0012163 abnormal dental mesenchyme morphology http://purl.obolibrary.org/obo/MP_0011260 abnormal head mesenchyme morphology any structural anomaly of the mesenchyme enclosed by dental organ http://purl.obolibrary.org/obo/MP_0012164 abnormal conjunctiva goblet cell morphology http://purl.obolibrary.org/obo/MP_0004481 abnormal conjunctival epithelium morphology any structural anomaly of a goblet cell that is part of the epithelium of the conjunctiva, and is the source of tear mucins which are secreted from it http://purl.obolibrary.org/obo/MP_0012165 absent neural folds http://purl.obolibrary.org/obo/MP_0011256 abnormal neural fold morphology absence of the elevated margins of the neural groove http://purl.obolibrary.org/obo/MP_0012166 absent neural plate http://purl.obolibrary.org/obo/MP_0005657 abnormal neural plate morphology absence of the flat, thickened layer of ectodermal cells in the neuroectodermal area of the embryo's dorsal surface that develops into the neural tube and neural crest http://purl.obolibrary.org/obo/MP_0012168 abnormal optic placode morphology http://purl.obolibrary.org/obo/MP_0005545 abnormal lens development any structural anomaly of the paired thickenings of surface ectoderm that become invaginated to form the embryonic lens vesicles http://purl.obolibrary.org/obo/MP_0012169 optic placode degeneration http://purl.obolibrary.org/obo/MP_0012168 abnormal optic placode morphology a retrogressive impairment of function or destruction of the paired thickenings of surface ectoderm that normally become invaginated to form the embryonic lens vesicles http://purl.obolibrary.org/obo/MP_0012170 absent optic placodes http://purl.obolibrary.org/obo/MP_0012168 abnormal optic placode morphology absence of the paired thickenings of surface ectoderm that normally become invaginated to form the embryonic lens vesicles http://purl.obolibrary.org/obo/MP_0012171 oligohydramnios http://purl.obolibrary.org/obo/MP_0001784 abnormal fluid regulation presence of an abnormally low amniotic fluid volume in the amniotic sac; the opposite of polyhydramnios http://purl.obolibrary.org/obo/MP_0012172 abnormal amniotic fluid composition http://purl.obolibrary.org/obo/MP_0001784 abnormal fluid regulation any alteration in the expected chemical makeup of the watery liquid within the amnion that surrounds and cushions a growing fetus; normally, early in gestation, amniotic fluid is similar to maternal plasma, mainly water with electrolytes, and later in gestation, proteins, carbohydrates, lipids, phospholipids originating from the lungs, fetal cells, and urea are deposited in the fluid http://purl.obolibrary.org/obo/MP_0012173 short rostral-caudal axis http://purl.obolibrary.org/obo/MP_0005221 abnormal rostral-caudal axis patterning length reduction or truncation of the axis that runs from the head to the tail of the body http://purl.obolibrary.org/obo/MP_0012174 flat head http://purl.obolibrary.org/obo/MP_0011495 abnormal head shape the appearance of a flattened surface outline or contour of a normally rounded head of an organism http://purl.obolibrary.org/obo/MP_0012175 flat face http://purl.obolibrary.org/obo/MP_0003743 abnormal facial morphology the appearance of a flattened surface outline or contour of a normally rounded face of an organism http://purl.obolibrary.org/obo/MP_0012177 delayed head development http://purl.obolibrary.org/obo/MP_0012176 abnormal head development late onset of the induction and/or differentiation of the head http://purl.obolibrary.org/obo/MP_0012178 absent frontonasal prominence http://purl.obolibrary.org/obo/MP_0009901 abnormal frontonasal prominence morphology absence of the unpaired embryonic prominence that is formed by the tissues surrounding the forebrain vesicle and develops into the forehead and bridge of the nose/snout http://purl.obolibrary.org/obo/MP_0012179 abnormal splanchnic mesoderm morphology http://purl.obolibrary.org/obo/MP_0010117 abnormal lateral plate mesoderm morphology any structural abnormality of the inner layer of lateral plate mesoderm, located above (dorsally) the endoderm, which forms the circulatory system and future gut wall http://purl.obolibrary.org/obo/MP_0012180 abnormal somatic mesoderm morphology http://purl.obolibrary.org/obo/MP_0010117 abnormal lateral plate mesoderm morphology any structural abnormality of the outer layer of lateral plate mesoderm, located under (ventrally) the ectoderm, which forms the future body wall http://purl.obolibrary.org/obo/MP_0012181 increased somite number http://purl.obolibrary.org/obo/MP_0001688 abnormal somite development increase in the average number of somites formed relative to littermates or other controls http://purl.obolibrary.org/obo/MP_0012182 abnormal presomitic mesoderm morphology http://purl.obolibrary.org/obo/MP_0008029 abnormal paraxial mesoderm morphology any structural anomaly of the unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form http://purl.obolibrary.org/obo/MP_0012183 decreased paraxial mesoderm size http://purl.obolibrary.org/obo/MP_0008029 abnormal paraxial mesoderm morphology reduced size or deficiency of the mesoderm lying at either side of the midline embryonic notochord that, on segmentation, forms the paired somites http://purl.obolibrary.org/obo/MP_0012184 absent paraxial mesoderm http://purl.obolibrary.org/obo/MP_0008029 abnormal paraxial mesoderm morphology absence or loss of the mesoderm normally found at either side of the midline embryonic notochord that, on segmentation, forms the paired somites. http://purl.obolibrary.org/obo/MP_0012185 abnormal muscle precursor cell morphology http://purl.obolibrary.org/obo/MP_0000729 abnormal myogenesis any structural anomaly of cells that will develop into muscle cells http://purl.obolibrary.org/obo/MP_0012187 abnormal intraembryonic coelom morphology http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology any structural anomaly of the part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom http://purl.obolibrary.org/obo/MP_0012188 increased regulatory T cell apoptosis http://purl.obolibrary.org/obo/MP_0006413 increased T cell apoptosis increase in the number of regulatory T cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0012189 decreased regulatory T cell apoptosis http://purl.obolibrary.org/obo/MP_0006414 decreased T cell apoptosis decrease in the number of regulatory T cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0012190 increased cytotoxic T cell apoptosis http://purl.obolibrary.org/obo/MP_0006413 increased T cell apoptosis increase in the number of cytotoxic T cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0012191 decreased cytotoxic T cell apoptosis http://purl.obolibrary.org/obo/MP_0006414 decreased T cell apoptosis decrease in the number of cytotoxic T cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0012192 abnormal keratinocyte migration http://purl.obolibrary.org/obo/MP_0003453 abnormal keratinocyte physiology anomaly in the movement of keratinocyes or their precursors to the appropriate location in the body http://purl.obolibrary.org/obo/MP_0012193 increased keratinocyte migration http://purl.obolibrary.org/obo/MP_0012192 abnormal keratinocyte migration increased or faster movement of keratinocyes or their precursors to the appropriate location in the body http://purl.obolibrary.org/obo/MP_0012194 decreased keratinocyte migration http://purl.obolibrary.org/obo/MP_0012192 abnormal keratinocyte migration reduced or slower movement of keratinocyes or their precursors to the appropriate location in the body http://purl.obolibrary.org/obo/MP_0012195 impaired neural crest cell differentiation http://purl.obolibrary.org/obo/MP_0009845 abnormal neural crest cell morphology abnormal or arrest of differentiation of the transient and highly migratory group of cells that delaminate in early embryonic development from the dorsal neural tube and give rise to a variety of differentiated cell types http://purl.obolibrary.org/obo/MP_0012196 abnormal myofibroblast differentiation http://purl.obolibrary.org/obo/MP_0005076 abnormal cell differentiation anomaly in the process in which a relatively unspecialized cell acquires specialized features of a myofibroblast, a cell that has characteristics of both a fibroblast cell and a smooth muscle cell and is reportedly capable of secreting IL-1beta, IL-6, and TNF-alpha http://purl.obolibrary.org/obo/MP_0012197 impaired myofibroblast differentiation http://purl.obolibrary.org/obo/MP_0012196 abnormal myofibroblast differentiation reduced ability or inability to produce myofibroblasts, cells that have characteristics of both a fibroblast cell and a smooth muscle cell and are reportedly capable of secreting IL-1beta, IL-6, and TNF-alpha http://purl.obolibrary.org/obo/MP_0012198 absent interphalangeal joint http://purl.obolibrary.org/obo/MP_0012199 abnormal interphalangeal joint absence of a hinge joint(s) that connects one phalanx to another along a proximodistal axis http://purl.obolibrary.org/obo/MP_0012199 abnormal interphalangeal joint http://purl.obolibrary.org/obo/MP_0002932 abnormal joint morphology any structural anomaly of a hinge joint that connects one phalanx to another along a proximodistal axis http://purl.obolibrary.org/obo/MP_0012200 increased endothelial cell proliferation http://purl.obolibrary.org/obo/MP_0012202 abnormal endothelial cell proliferation greater expansion rate of a endothelial cell population by cell division http://purl.obolibrary.org/obo/MP_0012201 decreased endothelial cell proliferation http://purl.obolibrary.org/obo/MP_0012202 abnormal endothelial cell proliferation reduction in the expansion rate of a endothelial cell population by cell division http://purl.obolibrary.org/obo/MP_0012202 abnormal endothelial cell proliferation http://purl.obolibrary.org/obo/MP_0000350 abnormal cell proliferation anomaly in the ability of an endothelial cell population to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0012203 abnormal neuronal stem cell morphology http://purl.obolibrary.org/obo/MP_0003861 abnormal nervous system development any structural anomaly of an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors http://purl.obolibrary.org/obo/MP_0012204 abnormal neuronal stem cell physiology http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology any functional anomaly of an undifferentiated cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple types of lineage-restricted progenitors http://purl.obolibrary.org/obo/MP_0012205 abnormal neuronal stem cell self-renewal http://purl.obolibrary.org/obo/MP_0012204 abnormal neuronal stem cell physiology any anomaly in the process by which stem cells divide and proliferate to make more stem cells, perpetuating the stem cell pool; self-renewal is division with maintenance of the undifferentiated state http://purl.obolibrary.org/obo/MP_0012206 increased neuronal stem cell self-renewal http://purl.obolibrary.org/obo/MP_0012205 abnormal neuronal stem cell self-renewal an increased rate in the process by which stem cells divide and proliferate to make more stem cells, perpetuating an increase in the stem cell pool; self-renewal is division with maintenance of the undifferentiated state http://purl.obolibrary.org/obo/MP_0012207 decreased neuronal stem cell self-renewal http://purl.obolibrary.org/obo/MP_0012205 abnormal neuronal stem cell self-renewal an decreased rate in the process by which stem cells divide and proliferate to make more stem cells, perpetuating an decrease in the stem cell pool; self-renewal is division with maintenance of the undifferentiated state http://purl.obolibrary.org/obo/MP_0012208 abnormal hypoxanthine-guanine phosphoribosyltransferase level http://purl.obolibrary.org/obo/MP_0005319 abnormal enzyme/ coenzyme level altered level of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate http://purl.obolibrary.org/obo/MP_0012209 decreased hypoxanthine-guanine phosphoribosyltransferase level http://purl.obolibrary.org/obo/MP_0012208 abnormal hypoxanthine-guanine phosphoribosyltransferase level reduced level of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate http://purl.obolibrary.org/obo/MP_0012210 increased hypoxanthine-guanine phosphoribosyltransferase level http://purl.obolibrary.org/obo/MP_0012208 abnormal hypoxanthine-guanine phosphoribosyltransferase level greater level of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate http://purl.obolibrary.org/obo/MP_0012211 decreased thalamus hypoxanthine-guanine phosphoribosyltransferase level http://purl.obolibrary.org/obo/MP_0012209 decreased hypoxanthine-guanine phosphoribosyltransferase level reduced level in the thalamus of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate http://purl.obolibrary.org/obo/MP_0012212 increased thalamus hypoxanthine-guanine phosphoribosyltransferase level http://purl.obolibrary.org/obo/MP_0012210 increased hypoxanthine-guanine phosphoribosyltransferase level greater level in the thalmus of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate http://purl.obolibrary.org/obo/MP_0012213 decreased hypothalamus hypoxanthine-guanine phosphoribosyltransferase level http://purl.obolibrary.org/obo/MP_0012209 decreased hypoxanthine-guanine phosphoribosyltransferase level reduced level in the hypothalamus of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate http://purl.obolibrary.org/obo/MP_0012214 increased hypothalamus hypoxanthine-guanine phosphoribosyltransferase level http://purl.obolibrary.org/obo/MP_0012210 increased hypoxanthine-guanine phosphoribosyltransferase level greater level in the hypothalmus of the enzyme that catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate http://purl.obolibrary.org/obo/MP_0012215 abnormal plasmalogen level http://purl.obolibrary.org/obo/MP_0012220 abnormal ether lipid level anomaly in the amount of the glycerophospholipid class of lipids that contain a vinyl ether moiety at the sn-1-position of the glycerol backbone and are and enriched in polyunsaturated fatty acids at the sn-2 position of the glycerol backbone http://purl.obolibrary.org/obo/MP_0012216 decreased plasmalogen level http://purl.obolibrary.org/obo/MP_0012215 abnormal plasmalogen level reduction in the amount of the glycerophospholipid class of lipids that contain a vinyl ether moiety at the sn-1-position of the glycerol backbone and are and enriched in polyunsaturated fatty acids at the sn-2 position of the glycerol backbone http://purl.obolibrary.org/obo/MP_0012217 increased plasmalogen level http://purl.obolibrary.org/obo/MP_0012215 abnormal plasmalogen level greater amount of the glycerophospholipid class of lipids that contain a vinyl ether moiety at the sn-1-position of the glycerol backbone and are and enriched in polyunsaturated fatty acids at the sn-2 position of the glycerol backbone http://purl.obolibrary.org/obo/MP_0012218 decreased brain plasmalogen level http://purl.obolibrary.org/obo/MP_0012216 decreased plasmalogen level reduction in the amount in the brain of the glycerophospholipid class of lipids that contain a vinyl ether moiety at the sn-1-position of the glycerol backbone and are and enriched in polyunsaturated fatty acids at the sn-2 position of the glycerol backbone http://purl.obolibrary.org/obo/MP_0012219 increased brain plasmalogen level http://purl.obolibrary.org/obo/MP_0012217 increased plasmalogen level greater amount in the brain of the glycerophospholipid class of lipids that contain a vinyl ether moiety at the sn-1-position of the glycerol backbone and are and enriched in polyunsaturated fatty acids at the sn-2 position of the glycerol backbone http://purl.obolibrary.org/obo/MP_0012220 abnormal ether lipid level http://purl.obolibrary.org/obo/MP_0004777 abnormal phospholipid level anomaly in the amount of lipids in which one or more of the carbon atoms on glycerol is bonded to an alkyl chain via an ether linkage, as opposed to the usual ester linkage http://purl.obolibrary.org/obo/MP_0012221 abnormal circulating prothrombin level http://purl.obolibrary.org/obo/MP_0005416 abnormal circulating protein level anomaly in the blood level of an inactive plasma serine protease precursor produced in the liver in the presence of vitamin K which is proteolytically cleaved into active thrombin by the action of various components (as thromboplastin) of the coagulation cascade http://purl.obolibrary.org/obo/MP_0012222 decreased circulating prothrombin level http://purl.obolibrary.org/obo/MP_0012221 abnormal circulating prothrombin level reduction in the blood level of an inactive plasma serine protease precursor produced in the liver in the presence of vitamin K which is proteolytically cleaved into active thrombin by the action of various components (as thromboplastin) of the coagulation cascade http://purl.obolibrary.org/obo/MP_0012223 increased circulating prothrombin level http://purl.obolibrary.org/obo/MP_0012221 abnormal circulating prothrombin level greater blood level of an inactive plasma serine protease precursor produced in the liver in the presence of vitamin K which is proteolytically cleaved into active thrombin by the action of various components (as thromboplastin) of the coagulation cascade http://purl.obolibrary.org/obo/MP_0012234 abnormal hepatic diverticulum morphology http://purl.obolibrary.org/obo/MP_0003943 abnormal hepatobiliary system development any structural anomaly of the out-pocket of thickened ventral foregut epithelium adjacent to the developing heart that constitutes the first morphological sign of the embryonic liver http://purl.obolibrary.org/obo/MP_0012235 abnormal liver bud morphology http://purl.obolibrary.org/obo/MP_0012234 abnormal hepatic diverticulum morphology any structural anomaly of the liver primordium formed as hepatoblasts delaminate from the anterior portion of the hepatic diverticulum and invade the adjacent septum transversum mesenchyme http://purl.obolibrary.org/obo/MP_0012236 abnormal cholangiocyte morphology http://purl.obolibrary.org/obo/MP_0002928 abnormal bile duct morphology any structural anomaly of the epithelial cells of the bile duct that have primary cilia extending from their apical membrane into the ductal lumen; cholangiocytes are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts http://purl.obolibrary.org/obo/MP_0012237 increased cholangiocyte apoptosis http://purl.obolibrary.org/obo/MP_0003252 abnormal bile duct physiology increase in the number of epithelial cells of the bile duct undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0012238 abnormal cholangiocyte primary cilium morphology http://purl.obolibrary.org/obo/MP_0012236 abnormal cholangiocyte morphology any structural anomaly of the primary cilia found on the epithelial cells of the bile duct and extending from their apical membrane into the ductal lumen http://purl.obolibrary.org/obo/MP_0012239 abnormal cholangiocyte primary cilium physiology http://purl.obolibrary.org/obo/MP_0013211 abnormal nonmotile primary cilium physiology any functional anomaly of the primary cilia found on the epithelial cells of the bile duct and extending from their apical membrane into the ductal lumen; cholangiocyte cilia respond to mechanical stimuli (i.e. luminal fluid flow) by alterations in intracellular Ca2+ and cAMP and are thought to act as osmosensors that play an important role in ductal bile formation by detecting changes in luminal tonicity and inducing bicarbonate secretion http://purl.obolibrary.org/obo/MP_0012240 abnormal hepatoblast morphology http://purl.obolibrary.org/obo/MP_0003943 abnormal hepatobiliary system development any structural anomaly of the bi-potent cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes http://purl.obolibrary.org/obo/MP_0012241 abnormal hepatoblast physiology http://purl.obolibrary.org/obo/MP_0002139 abnormal hepatobiliary system physiology any functional anomaly of the bi-potent cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes http://purl.obolibrary.org/obo/MP_0012242 abnormal hepatoblast differentiation http://purl.obolibrary.org/obo/MP_0012240 abnormal hepatoblast morphology developmental anomaly or inability of hepatoblasts to differentiate into hepatocytes and cholangiocytes http://purl.obolibrary.org/obo/MP_0012243 decreased hepatoblast number http://purl.obolibrary.org/obo/MP_0012240 abnormal hepatoblast morphology reduced number of the bi-potent cells that retain the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into hepatocytes and cholangiocytes http://purl.obolibrary.org/obo/MP_0012244 increased hepatoblast apoptosis http://purl.obolibrary.org/obo/MP_0012241 abnormal hepatoblast physiology increase in the number of hepatoblasts undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0012245 abnormal hepatoblast migration http://purl.obolibrary.org/obo/MP_0012241 abnormal hepatoblast physiology atypical migration of hepatoblasts across the basement membrane of the liver bud and/or invasion of the neighboring septum transversum mesenchyme http://purl.obolibrary.org/obo/MP_0012246 abnormal hepatic cord morphology http://purl.obolibrary.org/obo/MP_0000598 abnormal liver morphology any structural anomaly of the three-dimensional arrangement formed by plates of hepatocytes, usually one cell thick, that radiates from the center of the liver lobule; hepatic laminae are highly branched, irregular structures bordered by endothelial lined vascular spaces called hepatic sinusoids http://purl.obolibrary.org/obo/MP_0012247 absent cornea http://purl.obolibrary.org/obo/MP_0001312 abnormal cornea morphology absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure http://purl.obolibrary.org/obo/MP_0012248 absent dermatome http://purl.obolibrary.org/obo/MP_0003940 abnormal dermatome morphology absence of the mesoderm that is derived from the somite that is fated to become the dermis http://purl.obolibrary.org/obo/MP_0012249 absent myotome http://purl.obolibrary.org/obo/MP_0003939 abnormal myotome morphology absence of the mesoderm that is derived from the somite that is fated to become the musculature http://purl.obolibrary.org/obo/MP_0012250 absent heart valves http://purl.obolibrary.org/obo/MP_0000285 abnormal heart valve morphology failure to form all of the membranous folds of the heart that prevent reflux of fluid http://purl.obolibrary.org/obo/MP_0012251 abnormal diaphragm development http://purl.obolibrary.org/obo/MP_0002279 abnormal diaphragm morphology malformation or incomplete differentiation of the thin musculomembranous barrier separating the abdominal and thoracic cavities and functioning in respiration http://purl.obolibrary.org/obo/MP_0012252 abnormal septum transversum morphology http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology any structural anomaly of the thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions; the cranial part of the septum transversum gives rise to the central tendon of the diaphragm and is the origin of the myoblasts that invade the pleuroperitoneal folds resulting in the formation of the muscular diaphragm, and the caudal part of the septum transversum is invaded by the hepatic diverticulum which divides within it to form the liver and thus gives rise to the ventral mesentery of the foregut http://purl.obolibrary.org/obo/MP_0012254 absent intersomitic vessels http://purl.obolibrary.org/obo/MP_0012253 abnormal intersomitic vessel morphology absence of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites http://purl.obolibrary.org/obo/MP_0012255 abnormal intersomitic vein morphology http://purl.obolibrary.org/obo/MP_0012253 abnormal intersomitic vessel morphology any structural anomaly of the vein that sprouts from the posterior cardinal vein, growing dorsally between the somites, and then joining, and draining the dorsal longitudinal anastomosing vessel http://purl.obolibrary.org/obo/MP_0012256 abnormal philtrum morphology http://purl.obolibrary.org/obo/MP_0012523 abnormal upper lip morphology any structural anomaly of the vertical groove found on the median line of the upper lip http://purl.obolibrary.org/obo/MP_0012257 absent philtrum http://purl.obolibrary.org/obo/MP_0012256 abnormal philtrum morphology absence of the vertical groove normally found on the median line of the upper lip http://purl.obolibrary.org/obo/MP_0012258 philtrum hypoplasia http://purl.obolibrary.org/obo/MP_0012256 abnormal philtrum morphology underdevelopment or reduced size of the philtrum, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0012259 meningocele http://purl.obolibrary.org/obo/MP_0012547 spina bifida cystica a protrusion of meninges through dehiscences in the base of the skull or gaps between the vertebrae, resulting in a cyst filled with cerebrospinal fluid; nervous tissue remains unaffected http://purl.obolibrary.org/obo/MP_0012260 encephalomeningocele http://purl.obolibrary.org/obo/MP_0003632 abnormal nervous system morphology hernial protrusion of the brain and its meninges through an opening or defect in the skull, most often occurring in the occipital region http://purl.obolibrary.org/obo/MP_0012261 increased hindbrain apoptosis http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology increase in the number of cells of the hindbrain undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0012262 abnormal hindbrain size http://purl.obolibrary.org/obo/MP_0000841 abnormal hindbrain morphology deviation from the average range of hindbrain size compared to normal http://purl.obolibrary.org/obo/MP_0012263 decreased hindbrain size http://purl.obolibrary.org/obo/MP_0012262 abnormal hindbrain size size reduction or truncation of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived http://purl.obolibrary.org/obo/MP_0012264 hindbrain hypoplasia http://purl.obolibrary.org/obo/MP_0012263 decreased hindbrain size underdevelopment or reduced size, usually due to a reduced number of cells, of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived http://purl.obolibrary.org/obo/MP_0012265 increased hindbrain size http://purl.obolibrary.org/obo/MP_0012262 abnormal hindbrain size greater than average size of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived http://purl.obolibrary.org/obo/MP_0012266 hindbrain hyperplasia http://purl.obolibrary.org/obo/MP_0012265 increased hindbrain size overdevelopment or increased size, usually due to a increased number of cells, of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived http://purl.obolibrary.org/obo/MP_0012267 abnormal red nucleus morphology http://purl.obolibrary.org/obo/MP_0006100 abnormal tegmentum morphology any anomaly of the pale pink structure located in the tegmentum of the midbrain next to the substantia nigra and involved in motor coordination http://purl.obolibrary.org/obo/MP_0012268 absent red nucleus http://purl.obolibrary.org/obo/MP_0012267 abnormal red nucleus morphology absence of the pale pink structure located in the tegmentum of the midbrain next to the substantia nigra and involved in motor coordination http://purl.obolibrary.org/obo/MP_0012269 nuchal edema http://purl.obolibrary.org/obo/MP_0012723 abnormal nuchal region morphology abnormal accumulation of subcutaneous fluid in the nuchal region i.e. at the back of the neck http://purl.obolibrary.org/obo/MP_0012270 cardiac edema http://purl.obolibrary.org/obo/MP_0001785 edema abnormal accumulation of fluid in the interstitial tissues and cavities of the body due to impaired cardiac function or congestive heart failure; usually characterized by increased venous and capillary pressures and often associated with renal sodium retention http://purl.obolibrary.org/obo/MP_0012271 abnormal chordamesoderm morphology http://purl.obolibrary.org/obo/MP_0001684 abnormal axial mesoderm any structural anomaly of the area of axial mesoderm that develops into the notochord http://purl.obolibrary.org/obo/MP_0012272 decreased axial mesoderm size http://purl.obolibrary.org/obo/MP_0001684 abnormal axial mesoderm reduced size or deficiency of the part of the middle of the three primary germ layers of the embryo which includes the prechordal mesoderm and the chordamesoderm and gives rise to the prechordal plate and to the notochord http://purl.obolibrary.org/obo/MP_0012273 axial mesoderm hypoplasia http://purl.obolibrary.org/obo/MP_0012272 decreased axial mesoderm size underdevelopment or reduced size, usually due to a reduced number of cells, of the part of the middle of the three primary germ layers of the embryo which includes the prechordal mesoderm and the chordamesoderm and gives rise to the prechordal plate and to the notochord http://purl.obolibrary.org/obo/MP_0012274 increased axial mesoderm size http://purl.obolibrary.org/obo/MP_0001684 abnormal axial mesoderm greater than average size of the part of the middle of the three primary germ layers of the embryo which includes the prechordal mesoderm and the chordamesoderm and gives rise to the prechordal plate and to the notochord http://purl.obolibrary.org/obo/MP_0012275 abnormal prechordal mesoderm morphology http://purl.obolibrary.org/obo/MP_0001684 abnormal axial mesoderm any structural anomaly of the area of axial mesoderm that develops into the prechordal plate http://purl.obolibrary.org/obo/MP_0012276 absent prechordal mesoderm http://purl.obolibrary.org/obo/MP_0012275 abnormal prechordal mesoderm morphology absence of or failure to form the area of axial mesoderm that develops into the prechordal plate http://purl.obolibrary.org/obo/MP_0012277 increased tail bud apoptosis http://purl.obolibrary.org/obo/MP_0002861 abnormal tail bud morphology increased number of cells undergoing programmed cell death in the primordial region of the embryo that arises to form the tail of the adult http://purl.obolibrary.org/obo/MP_0012278 abnormal cardiogenic mesoderm morphology http://purl.obolibrary.org/obo/MP_0002925 abnormal cardiovascular development any structural anomaly of the splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium http://purl.obolibrary.org/obo/MP_0012279 wide sternum http://purl.obolibrary.org/obo/MP_0000157 abnormal sternum morphology an increase in the width of the long flat bone of the chest that articulates with the clavicle and first seven rib pairs http://purl.obolibrary.org/obo/MP_0012280 abnormal sternebra size http://purl.obolibrary.org/obo/MP_0004322 abnormal sternebra morphology atypical size of any of the segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum http://purl.obolibrary.org/obo/MP_0012281 decreased sternebra size http://purl.obolibrary.org/obo/MP_0012280 abnormal sternebra size reduced average size of any of the segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum http://purl.obolibrary.org/obo/MP_0012282 abnormal sternebra number http://purl.obolibrary.org/obo/MP_0004322 abnormal sternebra morphology deviation from the average number of the segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum http://purl.obolibrary.org/obo/MP_0012283 decreased sternebra number http://purl.obolibrary.org/obo/MP_0012282 abnormal sternebra number reduced average number of the segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum http://purl.obolibrary.org/obo/MP_0012284 increased sternebra number http://purl.obolibrary.org/obo/MP_0012282 abnormal sternebra number increased average number of the segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum http://purl.obolibrary.org/obo/MP_0012285 misaligned sternebrae http://purl.obolibrary.org/obo/MP_0004322 abnormal sternebra morphology abnormal alignment of the sternebrae along the ventral midline http://purl.obolibrary.org/obo/MP_0012286 decreased frequency of paradoxical sleep http://purl.obolibrary.org/obo/MP_0003194 abnormal frequency of paradoxical sleep decreased incidence or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity http://purl.obolibrary.org/obo/MP_0012287 increased frequency of paradoxical sleep http://purl.obolibrary.org/obo/MP_0003194 abnormal frequency of paradoxical sleep increased incidence or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity http://purl.obolibrary.org/obo/MP_0012289 abnormal non-rapid eye movement sleep pattern http://purl.obolibrary.org/obo/MP_0001501 abnormal sleep pattern any anomaly in the frequency or duration of the sleep stages characterized by distinct EEG patterns, decreased metabolic activity, slowed breathing and heart rate, and the absence of rapid eye movement and dreaming http://purl.obolibrary.org/obo/MP_0012290 abnormal slow-wave sleep pattern http://purl.obolibrary.org/obo/MP_0012289 abnormal non-rapid eye movement sleep pattern any anonaly in the third, or deep sleep stage of NREM sleep http://purl.obolibrary.org/obo/MP_0012291 increased slow-wave sleep duration http://purl.obolibrary.org/obo/MP_0012290 abnormal slow-wave sleep pattern increased length of time of the third, or deep sleep stage of NREM sleep http://purl.obolibrary.org/obo/MP_0012292 decreased slow-wave sleep duration http://purl.obolibrary.org/obo/MP_0012290 abnormal slow-wave sleep pattern reduced length of time of the third, or deep sleep stage of NREM sleep http://purl.obolibrary.org/obo/MP_0012293 impaired active avoidance behavior http://purl.obolibrary.org/obo/MP_0012312 impaired avoidance learning behavior impaired ability to escape a hostile environment to actively avoid the unpleasant or punishing stimuli ( e.g. shock) previously encountered in this environment http://purl.obolibrary.org/obo/MP_0012294 enhanced active avoidance behavior http://purl.obolibrary.org/obo/MP_0012313 enhanced avoidance learning behavior enhanced ability to escape a hostile environment to actively avoid the unpleasant or punishing stimuli ( e.g. shock) previously encountered in this environment http://purl.obolibrary.org/obo/MP_0012295 enhanced discrimination learning http://purl.obolibrary.org/obo/MP_0012314 enhanced learning enhanced ability to exhibit a differential response to different stimuli that is achieved by the reinforcement of the desired response for each particular stimulus http://purl.obolibrary.org/obo/MP_0012297 hyperactivity elicited by feed restriction http://purl.obolibrary.org/obo/MP_0008911 induced hyperactivity increased activity after restriction of food http://purl.obolibrary.org/obo/MP_0012298 hypoactivity in response to feed restriction http://purl.obolibrary.org/obo/MP_0001402 hypoactivity decreased activity after restriction of food http://purl.obolibrary.org/obo/MP_0012299 hydropic allantois http://purl.obolibrary.org/obo/MP_0001726 abnormal allantois morphology excessive accumulation of fluid within the allantoic sac http://purl.obolibrary.org/obo/MP_0012301 absent umbilical cord blood vessels http://purl.obolibrary.org/obo/MP_0012300 abnormal umbilical cord blood vessel morphology absence of any of the three blood vessels, usually one large umbilical vein and two small umbilical arteries, buried within Wharton's jelly, that transport blood to and from the placenta, where exchange between the mother and fetus takes place http://purl.obolibrary.org/obo/MP_0012302 umbilical artery stenosis http://purl.obolibrary.org/obo/MP_0003230 abnormal umbilical artery morphology abnormal constriction or narrowing of one or both umbilical arteries that carry deoxygenated, nutrient-depleted blood from the fetus to the placenta http://purl.obolibrary.org/obo/MP_0012303 umbilical vein stenosis http://purl.obolibrary.org/obo/MP_0010667 abnormal umbilical vein morphology abnormal constriction or narrowing of the unpaired umbilical vein that carries oxygenated, nutrient-rich blood from the placenta to the fetus http://purl.obolibrary.org/obo/MP_0012304 short umbilical cord http://purl.obolibrary.org/obo/MP_0001725 abnormal umbilical cord morphology decreased average umbilical cord length compared to normal http://purl.obolibrary.org/obo/MP_0012305 umbilical cord hemorrhage http://purl.obolibrary.org/obo/MP_0001725 abnormal umbilical cord morphology bleeding into or from the umbilical cord http://purl.obolibrary.org/obo/MP_0012306 enhanced spatial learning http://purl.obolibrary.org/obo/MP_0012314 enhanced learning enhanced ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues http://purl.obolibrary.org/obo/MP_0012307 impaired spatial learning http://purl.obolibrary.org/obo/MP_0012315 impaired learning impaired ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues http://purl.obolibrary.org/obo/MP_0012308 salt preference http://purl.obolibrary.org/obo/MP_0001432 abnormal food preference subjects demonstrate predilection for salty tasting substances over other offered substances http://purl.obolibrary.org/obo/MP_0012309 abnormal ductus caroticus morphology http://purl.obolibrary.org/obo/MP_0004787 abnormal dorsal aorta morphology any structural anomaly of the segment of dorsal aorta located between the third (III) and fourth (IV) aortic arches; it normally regresses early in development to allow the carotid axis to take its definitive appearance http://purl.obolibrary.org/obo/MP_0012310 persistent ductus caroticus http://purl.obolibrary.org/obo/MP_0010464 abnormal aortic arch and aortic arch branch attachment uni- or bilateral persistence of the segment of dorsal aorta located between the third (III) and fourth (IV) aortic arches, which normally regresses early in development; persistence of ductus caroticus with regression of third arch or fourth arch causes the internal and external carotid arteries to arise from the aortic arch on the left side http://purl.obolibrary.org/obo/MP_0012311 decreased defecation amount http://purl.obolibrary.org/obo/MP_0020147 abnormal defecation amount decrease in the amount of discharge of feces from the body http://purl.obolibrary.org/obo/MP_0012314 enhanced learning http://purl.obolibrary.org/obo/MP_0002063 abnormal learning/memory/conditioning enhanced ability to aquire lasting change in behavior that is the result of experience http://purl.obolibrary.org/obo/MP_0012315 impaired learning http://purl.obolibrary.org/obo/MP_0002063 abnormal learning/memory/conditioning impaired ability to aquire lasting change in behavior that is the result of experience http://purl.obolibrary.org/obo/MP_0012318 slow extinction of fear memory http://purl.obolibrary.org/obo/MP_0003106 abnormal fear-related response impaired ability or inability to extinguish aversive memories associated with a traumatic incident http://purl.obolibrary.org/obo/MP_0012319 fast extinction of fear memory http://purl.obolibrary.org/obo/MP_0003106 abnormal fear-related response enhanced ability to extinguish aversive memories associated with a traumatic incident http://purl.obolibrary.org/obo/MP_0012320 abnormal body fat mass http://purl.obolibrary.org/obo/MP_0005451 abnormal body composition aberrant fat-containing physical bulk or volume of the body http://purl.obolibrary.org/obo/MP_0012321 abnormal total tissue mass http://purl.obolibrary.org/obo/MP_0005451 abnormal body composition aberrant physical bulk or volume of the body including lean body mass, fat body mass, and bone tissue http://purl.obolibrary.org/obo/MP_0012324 abnormal circulating antithrombin level http://purl.obolibrary.org/obo/MP_0005416 abnormal circulating protein level aberrant blood level of the family of glycoproteins which neutralize the ability of thrombin to promote blood coagulation http://purl.obolibrary.org/obo/MP_0012325 decreased circulating antithrombin level http://purl.obolibrary.org/obo/MP_0012324 abnormal circulating antithrombin level lower than normal levels of the family of glycoproteins which neutralize the ability of thrombin to promote blood coagulation; low levels are associated with vein thrombosis and pulmonary embolism http://purl.obolibrary.org/obo/MP_0012326 increased circulating antithrombin level http://purl.obolibrary.org/obo/MP_0012324 abnormal circulating antithrombin level higher than normal levels of the family of glycoproteins which neutralize the ability of thrombin to promote blood coagulation http://purl.obolibrary.org/obo/MP_0012327 abnormal circulating factor VIII level http://purl.obolibrary.org/obo/MP_0005416 abnormal circulating protein level aberrant levels of the antihemophilic factor that is part of the factor VIII/von Willebrand factor complex; it is produced in the liver and acts in the intrinsic pathway of blood coagulation; it serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin http://purl.obolibrary.org/obo/MP_0012328 decreased circulating factor VIII level http://purl.obolibrary.org/obo/MP_0012327 abnormal circulating factor VIII level reduced levels of the antihemophilic factor that is part of the factor VIII/von Willebrand factor complex; it is produced in the liver and acts in the intrinsic pathway of blood coagulation; it serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin http://purl.obolibrary.org/obo/MP_0012329 increased circulating factor VIII level http://purl.obolibrary.org/obo/MP_0012327 abnormal circulating factor VIII level greater levels of the antihemophilic factor that is part of the factor VIII/von Willebrand factor complex; it is produced in the liver and acts in the intrinsic pathway of blood coagulation; it serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin http://purl.obolibrary.org/obo/MP_0012330 decreased circulating fibrinogen level http://purl.obolibrary.org/obo/MP_0010213 abnormal circulating fibrinogen level reduced levels in the blood of a globulin that is converted into fibrin by the action of thrombin in the presence of ionized calcium to produce coagulation of the blood http://purl.obolibrary.org/obo/MP_0012331 increased circulating fibrinogen level http://purl.obolibrary.org/obo/MP_0010213 abnormal circulating fibrinogen level greater levels in the blood of a globulin that is converted into fibrin by the action of thrombin in the presence of ionized calcium to produce coagulation of the blood http://purl.obolibrary.org/obo/MP_0012332 decreased circulating fibronectin level http://purl.obolibrary.org/obo/MP_0011912 abnormal circulating fibronectin level reduced blood level of the glycoprotein that binds to integrins or components of the extracellular matrix; plays a major role in cell adhesion, growth, migration, differentiation, wound healing, and embryonic development http://purl.obolibrary.org/obo/MP_0012333 increased circulating fibronectin level http://purl.obolibrary.org/obo/MP_0011912 abnormal circulating fibronectin level greater blood level of the glycoprotein that binds to integrins or components of the extracellular matrix; plays a major role in cell adhesion, growth, migration, differentiation, wound healing, and embryonic development http://purl.obolibrary.org/obo/MP_0012334 decreased circulating homocysteine level http://purl.obolibrary.org/obo/MP_0006076 abnormal circulating homocysteine level reduced amount in the blood of sulfur-containing alpha-amino acid found in the plasma; blood levels are regulated by folic acid, vitamin B6 and vitamin B12 http://purl.obolibrary.org/obo/MP_0012335 increased circulating homocysteine level http://purl.obolibrary.org/obo/MP_0006076 abnormal circulating homocysteine level greater amount in the blood of sulfur-containing alpha-amino acid found in the plasma; blood levels are regulated by folic acid, vitamin B6 and vitamin B12 http://purl.obolibrary.org/obo/MP_0012336 decreased vitamin D level http://purl.obolibrary.org/obo/MP_0011228 abnormal vitamin D level reduced level of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3) http://purl.obolibrary.org/obo/MP_0012337 increased vitamin D level http://purl.obolibrary.org/obo/MP_0011228 abnormal vitamin D level greater level of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism; specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3) http://purl.obolibrary.org/obo/MP_0012338 decreased bile salt level http://purl.obolibrary.org/obo/MP_0004774 abnormal bile salt level reduced level of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary system as bile salts; these play an important role in the digestion and absorption of fats http://purl.obolibrary.org/obo/MP_0012339 hyperkalemia http://purl.obolibrary.org/obo/MP_0005627 increased circulating potassium level excessively high concentrations of potassium in the circulating blood; may be due to renal insufficiency or to mineralocorticoid deficiency or resistance http://purl.obolibrary.org/obo/MP_0012340 decreased testicular teratoma incidence http://purl.obolibrary.org/obo/MP_0012417 decreased reproductive system tumor incidence less than the expected number of a usually benign tumor found in the testis that is the result of an anomaly of germ cell development, occurring in a specific population in a given time period; teratomas typically contains a diversity of tissues often representing all organ systems such as hair, teeth, bone, thyroid, or nerve tissue http://purl.obolibrary.org/obo/MP_0012341 low preference for an addictive substance http://purl.obolibrary.org/obo/MP_0002553 preference for addictive substance reduced behavioral response induced by a foreign compound, such as low consumption preference, low induced hyperactivity or stereotypic behavior http://purl.obolibrary.org/obo/MP_0012342 high preference for an addictive substance http://purl.obolibrary.org/obo/MP_0002553 preference for addictive substance enhanced behavioral response induced by a foreign compound, such as high consumption preference, high induced hyperactivity or stereotypic behavior http://purl.obolibrary.org/obo/MP_0012343 increased gnawing activity http://purl.obolibrary.org/obo/MP_0003491 abnormal voluntary movement increased biting or chewing on something http://purl.obolibrary.org/obo/MP_0012344 decreased gnawing activity http://purl.obolibrary.org/obo/MP_0003491 abnormal voluntary movement decreased biting or chewing on something http://purl.obolibrary.org/obo/MP_0012345 increased tail rattling http://purl.obolibrary.org/obo/MP_0001391 abnormal tail movements increased movement of the tail in rapid succession http://purl.obolibrary.org/obo/MP_0012346 decreased tail rattling http://purl.obolibrary.org/obo/MP_0001391 abnormal tail movements decreased movement of the tail in rapid succession http://purl.obolibrary.org/obo/MP_0012347 low sweet preference http://purl.obolibrary.org/obo/MP_0011976 sweet preference subjects demonstrate a low predilection for sweet tasting substances over other offered substances http://purl.obolibrary.org/obo/MP_0012350 increased aggression towards males in competition for females http://purl.obolibrary.org/obo/MP_0002566 abnormal sexual interaction when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward males when in competition for females http://purl.obolibrary.org/obo/MP_0012351 cornea degeneration http://purl.obolibrary.org/obo/MP_0001312 abnormal cornea morphology a retrogressive impairment of function or destruction of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure http://purl.obolibrary.org/obo/MP_0012352 progressive cornea degeneration http://purl.obolibrary.org/obo/MP_0012351 cornea degeneration the state or process of the cornea deteriorating progressively over time http://purl.obolibrary.org/obo/MP_0012353 bilateral cornea degeneration http://purl.obolibrary.org/obo/MP_0012351 cornea degeneration the state or process of the cornea deteriorating in both eyes http://purl.obolibrary.org/obo/MP_0012354 abnormal prothrombin time http://purl.obolibrary.org/obo/MP_0002551 abnormal blood coagulation abnormal amount of time it takes plasma to clot after the addition of tissue factor e.g., platelet tissue factor, factor III, thromboplastin, CD142; measure of the quality of the extrinsic pathway of coagulation http://purl.obolibrary.org/obo/MP_0012355 decreased prothrombin time http://purl.obolibrary.org/obo/MP_0012354 abnormal prothrombin time decreased amount of time it takes plasma to clot after the addition of tissue factor e.g., platelet tissue factor, factor III, thromboplastin, CD142; measure of the quality of the extrinsic pathway of coagulation http://purl.obolibrary.org/obo/MP_0012356 increased prothrombin time http://purl.obolibrary.org/obo/MP_0012354 abnormal prothrombin time increased amount of time it takes plasma to clot after the addition of tissue factor e.g., platelet tissue factor, factor III, thromboplastin, CD142; measure of the quality of the extrinsic pathway of coagulation http://purl.obolibrary.org/obo/MP_0012357 abnormal partial thromboplastin time http://purl.obolibrary.org/obo/MP_0002551 abnormal blood coagulation abnormal amount of time it takes blood to clot after the addition of phospholipid, calcium, and an activator, e.g., silica, kaolin; measure of the quality of the intrinsic and common coagulation pathways http://purl.obolibrary.org/obo/MP_0012358 decreased partial thromboplastin time http://purl.obolibrary.org/obo/MP_0012357 abnormal partial thromboplastin time decreased amount of time it takes blood to clot after the addition of phospholipid, calcium, and an activator, e.g., silica, kaolin; measure of the quality of the intrinsic and common coagulation pathways http://purl.obolibrary.org/obo/MP_0012359 increased partial thromboplastin time http://purl.obolibrary.org/obo/MP_0012357 abnormal partial thromboplastin time increased amount of time it takes blood to clot after the addition of phospholipid, calcium, and an activator, e.g., silica, kaolin; measure of the quality of the intrinsic and common coagulation pathways http://purl.obolibrary.org/obo/MP_0012360 abnormal large unstained cell number http://purl.obolibrary.org/obo/MP_0000716 abnormal immune system cell morphology aberrant number of larger than normal cells which are unstained using routine blood count methodologies; large unstained cells (LUC) are larger than normal lymphocytes, and may be atypical lymphocytes, myeloperoxidase deficient cells or peroxidase negative blasts http://purl.obolibrary.org/obo/MP_0012361 decreased large unstained cell number http://purl.obolibrary.org/obo/MP_0012360 abnormal large unstained cell number decreased number of larger than normal cells which are unstained using routine blood count methodologies; large unstained cells (LUC) are larger than normal lymphocytes, and may be atypical lymphocytes, myeloperoxidase deficient cells or peroxidase negative blasts http://purl.obolibrary.org/obo/MP_0012362 increased large unstained cell number http://purl.obolibrary.org/obo/MP_0012360 abnormal large unstained cell number increased number of larger than normal cells which are unstained using routine blood count methodologies; large unstained cells (LUC) are larger than normal lymphocytes, and may be atypical lymphocytes, myeloperoxidase deficient cells or peroxidase negative blasts http://purl.obolibrary.org/obo/MP_0012363 abnormal erythrocyte sodium level http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology anomaly in the amount in red blood cells of sodium http://purl.obolibrary.org/obo/MP_0012364 decreased erythrocyte sodium level http://purl.obolibrary.org/obo/MP_0012363 abnormal erythrocyte sodium level decrease in the amount in red blood cells of sodium http://purl.obolibrary.org/obo/MP_0012365 increased erythrocyte sodium level http://purl.obolibrary.org/obo/MP_0012363 abnormal erythrocyte sodium level increase in the amount in red blood cells of sodium http://purl.obolibrary.org/obo/MP_0012366 abnormal erythrocyte magnesium level http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology anomaly in the amount in red blood cells of magnesium http://purl.obolibrary.org/obo/MP_0012367 decreased erythrocyte magnesium level http://purl.obolibrary.org/obo/MP_0012366 abnormal erythrocyte magnesium level decrease in the amount in red blood cells of magnesium http://purl.obolibrary.org/obo/MP_0012368 increased erythrocyte magnesium level http://purl.obolibrary.org/obo/MP_0012366 abnormal erythrocyte magnesium level increase in the amount in red blood cells of magnesium http://purl.obolibrary.org/obo/MP_0012369 abnormal erythrocyte potassium level http://purl.obolibrary.org/obo/MP_0002668 abnormal circulating potassium level anomaly in the amount in red blood cells of potassium http://purl.obolibrary.org/obo/MP_0012370 decreased erythrocyte potassium level http://purl.obolibrary.org/obo/MP_0012369 abnormal erythrocyte potassium level decrease in the amount in red blood cells of potassium http://purl.obolibrary.org/obo/MP_0012371 increased erythrocyte potassium level http://purl.obolibrary.org/obo/MP_0012369 abnormal erythrocyte potassium level increase in the amount in red blood cells of potassium http://purl.obolibrary.org/obo/MP_0012372 abnormal erythrocyte ion content http://purl.obolibrary.org/obo/MP_0002447 abnormal erythrocyte morphology abnormal quantity in red blood cells of atoms carrying an electric charge http://purl.obolibrary.org/obo/MP_0012373 abnormal erythrocyte magnesium ion content http://purl.obolibrary.org/obo/MP_0012372 abnormal erythrocyte ion content abnormal quantity in red blood cells of magnesium atoms carrying an electric charge http://purl.obolibrary.org/obo/MP_0012374 decreased erythrocyte magnesium ion content http://purl.obolibrary.org/obo/MP_0012373 abnormal erythrocyte magnesium ion content decreased quantity in red blood cells of magnesium atoms carrying an electric charge http://purl.obolibrary.org/obo/MP_0012375 increased erythrocyte magnesium ion content http://purl.obolibrary.org/obo/MP_0012373 abnormal erythrocyte magnesium ion content increased quantity in red blood cells of magnesium atoms carrying an electric charge http://purl.obolibrary.org/obo/MP_0012376 abnormal erythrocyte potassium ion content http://purl.obolibrary.org/obo/MP_0012372 abnormal erythrocyte ion content abnormal quantity in red blood cells of potassium atoms carrying an electric charge http://purl.obolibrary.org/obo/MP_0012377 decreased erythrocyte potassium ion content http://purl.obolibrary.org/obo/MP_0012376 abnormal erythrocyte potassium ion content decreased quantity in red blood cells of potassium atoms carrying an electric charge http://purl.obolibrary.org/obo/MP_0012378 increased erythrocyte potassium ion content http://purl.obolibrary.org/obo/MP_0012376 abnormal erythrocyte potassium ion content increased quantity in red blood cells of potassium atoms carrying an electric charge http://purl.obolibrary.org/obo/MP_0012379 abnormal erythrocyte sodium ion content http://purl.obolibrary.org/obo/MP_0012372 abnormal erythrocyte ion content abnormal quantity in red blood cells of sodium atoms carrying an electric charge http://purl.obolibrary.org/obo/MP_0012380 decreased erythrocyte sodium ion content http://purl.obolibrary.org/obo/MP_0012379 abnormal erythrocyte sodium ion content decreased quantity in red blood cells of sodium atoms carrying an electric charge http://purl.obolibrary.org/obo/MP_0012381 increased erythrocyte sodium ion content http://purl.obolibrary.org/obo/MP_0012379 abnormal erythrocyte sodium ion content increased quantity in red blood cells of sodium atoms carrying an electric charge http://purl.obolibrary.org/obo/MP_0012384 abnormal erythrocyte ion transport http://purl.obolibrary.org/obo/MP_0003656 abnormal erythrocyte physiology aberrant measurable or observable characteristic related to the movement in red blood cells of atoms carrying an electric charge http://purl.obolibrary.org/obo/MP_0012385 abnormal erythrocyte potassium:chloride symporter activity http://purl.obolibrary.org/obo/MP_0012384 abnormal erythrocyte ion transport aberrant catalysis in red blood cells of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in) http://purl.obolibrary.org/obo/MP_0012386 decreased erythrocyte potassium:chloride symporter activity http://purl.obolibrary.org/obo/MP_0012385 abnormal erythrocyte potassium:chloride symporter activity decreased catalysis in red blood cells of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in) http://purl.obolibrary.org/obo/MP_0012387 increased erythrocyte potassium:chloride symporter activity http://purl.obolibrary.org/obo/MP_0012385 abnormal erythrocyte potassium:chloride symporter activity increased catalysis in red blood cells of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in) http://purl.obolibrary.org/obo/MP_0012388 abnormal erythrocyte sodium:hydrogen antiporter activity http://purl.obolibrary.org/obo/MP_0012384 abnormal erythrocyte ion transport aberrant catalysis in red blood cells of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out) http://purl.obolibrary.org/obo/MP_0012389 decreased erythrocyte sodium:hydrogen antiporter activity http://purl.obolibrary.org/obo/MP_0012388 abnormal erythrocyte sodium:hydrogen antiporter activity decreased catalysis in red blood cells of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out) http://purl.obolibrary.org/obo/MP_0012390 increased erythrocyte sodium:hydrogen antiporter activity http://purl.obolibrary.org/obo/MP_0012388 abnormal erythrocyte sodium:hydrogen antiporter activity increased catalysis in red blood cells of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out) http://purl.obolibrary.org/obo/MP_0012391 abnormal erythrocyte sodium:potassium-exchanging ATPase activity http://purl.obolibrary.org/obo/MP_0012384 abnormal erythrocyte ion transport aberrant catalysis in red blood cells of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in) http://purl.obolibrary.org/obo/MP_0012392 decreased erythrocyte sodium:potassium-exchanging ATPase activity http://purl.obolibrary.org/obo/MP_0012391 abnormal erythrocyte sodium:potassium-exchanging ATPase activity decreased catalysis in red blood cells of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in) http://purl.obolibrary.org/obo/MP_0012393 increased erythrocyte sodium:potassium-exchanging ATPase activity http://purl.obolibrary.org/obo/MP_0012391 abnormal erythrocyte sodium:potassium-exchanging ATPase activity increased catalysis in red blood cells of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in) http://purl.obolibrary.org/obo/MP_0012394 abnormal erythrocyte calcium-activated potassium channel activity http://purl.obolibrary.org/obo/MP_0012384 abnormal erythrocyte ion transport aberrant catalysis in red blood cells of the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient http://purl.obolibrary.org/obo/MP_0012395 decreased erythrocyte calcium-activated potassium channel activity http://purl.obolibrary.org/obo/MP_0012394 abnormal erythrocyte calcium-activated potassium channel activity decreased catalysis in red blood cells of the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient http://purl.obolibrary.org/obo/MP_0012396 increased erythrocyte calcium-activated potassium channel activity http://purl.obolibrary.org/obo/MP_0012394 abnormal erythrocyte calcium-activated potassium channel activity increased catalysis in red blood cells of the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient http://purl.obolibrary.org/obo/MP_0012398 decreased nucleated erythrocyte cell number http://purl.obolibrary.org/obo/MP_0012397 abnormal nucleated erythrocyte cell number decreased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells http://purl.obolibrary.org/obo/MP_0012399 short nails http://purl.obolibrary.org/obo/MP_0000579 abnormal nail morphology decrease in the length of the nails http://purl.obolibrary.org/obo/MP_0012400 nail dystrophy http://purl.obolibrary.org/obo/MP_0000579 abnormal nail morphology the presence of misshapen or partially destroyed nail plates, fequently with keratin often accumulating between the dystrophic nail plate and nail bed; often due to trauma or infection http://purl.obolibrary.org/obo/MP_0012402 abnormal nail bed morphology http://purl.obolibrary.org/obo/MP_0000579 abnormal nail morphology any structural anomaly of the dermis and epidermis directly below the nail plate http://purl.obolibrary.org/obo/MP_0012403 abnormal nail plate morphology http://purl.obolibrary.org/obo/MP_0000579 abnormal nail morphology any structural anomally of the hard and translucent portion of the nail, composed of keratin, which serves to protect the tips of digits http://purl.obolibrary.org/obo/MP_0012404 abnormal nail color http://purl.obolibrary.org/obo/MP_0000579 abnormal nail morphology a variation in an expected nail color, that may be due to infection, inflammation or other causes http://purl.obolibrary.org/obo/MP_0012405 abnormal nail matrix morphology http://purl.obolibrary.org/obo/MP_0000579 abnormal nail morphology any structural anomaly of the nail-forming area of the nail bed comprised of a germinal matrix, responsible for most of the nail production, and the sterile matrix, a secondary site of nail production which is tightly adherent to the nail plate http://purl.obolibrary.org/obo/MP_0012406 increased stomach glandular epithelium tumor incidence http://purl.obolibrary.org/obo/MP_0010301 increased stomach tumor incidence greater than the expected number of tumors originating in the stomach glandular epithelium in a given population in a given time period http://purl.obolibrary.org/obo/MP_0012407 increased gastric gastrinoma incidence http://purl.obolibrary.org/obo/MP_0012406 increased stomach glandular epithelium tumor incidence higher than normal incidence of an epithelial tumor in the stomach that secretes an excess of gastrin, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0012408 increased duodenum glandular epithelium tumor incidence http://purl.obolibrary.org/obo/MP_0010279 increased gastrointestinal tumor incidence greater than the expected number of tumors originating in the duodenal glandular epithelium in a given population in a given time period http://purl.obolibrary.org/obo/MP_0012409 increased duodenal gastrinoma incidence http://purl.obolibrary.org/obo/MP_0012408 increased duodenum glandular epithelium tumor incidence higher than normal incidence of an epithelial tumor in the duodenum that secretes an excess of gastrin, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0012410 increased pancreatic gastrinoma incidence http://purl.obolibrary.org/obo/MP_0009153 increased pancreas tumor incidence higher than normal incidence of a tumor in the pancreas that secretes an excess of gastrin, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0012411 increased granulosa cell tumor incidence http://purl.obolibrary.org/obo/MP_0008000 increased ovary tumor incidence greater than the expected number of neoplasms derived from somatic cells of the sex cord in the ovary a given population in a given time period http://purl.obolibrary.org/obo/MP_0012412 increased Type B reticulum cell tumor incidence http://purl.obolibrary.org/obo/MP_0010296 increased hemolymphoid system tumor incidence greater than the expected number of neoplasms derived from reticulum cells in a given population in a given time period; type B neoplasms are tumors of mixed cellularity of reticulum cells, lymphocytes, plasma cells, eosinophils, and neutrophils http://purl.obolibrary.org/obo/MP_0012413 decreased muscle tumor incidence http://purl.obolibrary.org/obo/MP_0010282 decreased organ/body region tumor incidence less than the expected number of tumors originating in muscle tissue in a given population in a given time period http://purl.obolibrary.org/obo/MP_0012414 decreased rhabdomyosarcoma incidence http://purl.obolibrary.org/obo/MP_0012415 decreased sarcoma incidence less than the expected number of a malignant tumor derived from skeletal (striated) muscle, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0012415 decreased sarcoma incidence http://purl.obolibrary.org/obo/MP_0010283 decreased classified tumor incidence less than the expected number of a connective tissue neoplasm associated with the proliferation of embryonically-derived mesodermal cells, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0012417 decreased reproductive system tumor incidence http://purl.obolibrary.org/obo/MP_0010282 decreased organ/body region tumor incidence less than the expected number of tumors originating in the reproductive system in a given population in a given time period http://purl.obolibrary.org/obo/MP_0012418 decreased eye tumor incidence http://purl.obolibrary.org/obo/MP_0010282 decreased organ/body region tumor incidence less than the expected number of tumors originating in the eye in a given population in a given time period http://purl.obolibrary.org/obo/MP_0012419 decreased cardiovascular system tumor incidence http://purl.obolibrary.org/obo/MP_0010282 decreased organ/body region tumor incidence less than the expected number of tumors originating in the cardiovascular system in a given population in a given time period http://purl.obolibrary.org/obo/MP_0012420 decreased hemolymphoid system tumor incidence http://purl.obolibrary.org/obo/MP_0010282 decreased organ/body region tumor incidence less than the expected number of tumors originating in the hemolymphoid system in a given population in a given time period http://purl.obolibrary.org/obo/MP_0012423 decreased nervous system tumor incidence http://purl.obolibrary.org/obo/MP_0010282 decreased organ/body region tumor incidence less than the expected number of tumors originating in the nervous system in a given population in a given time period http://purl.obolibrary.org/obo/MP_0012425 decreased respiratory system tumor incidence http://purl.obolibrary.org/obo/MP_0010282 decreased organ/body region tumor incidence less than the expected number of tumors originating in the respiratory system in a given population in a given time period http://purl.obolibrary.org/obo/MP_0012426 decreased skeletal tumor incidence http://purl.obolibrary.org/obo/MP_0010282 decreased organ/body region tumor incidence less than the expected number of neoplasms in the skeletal tissue, usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0012427 decreased urinary system tumor incidence http://purl.obolibrary.org/obo/MP_0010282 decreased organ/body region tumor incidence less than the expected number of tumors originating in the urinary system in a given population in a given time period http://purl.obolibrary.org/obo/MP_0012428 decreased granulosa cell tumor incidence http://purl.obolibrary.org/obo/MP_0012433 decreased ovarian tumor incidence less than the expected number of neoplasms derived from somatic cells of the sex cord in the ovary a given population in a given time period http://purl.obolibrary.org/obo/MP_0012429 decreased myoepithelioma incidence http://purl.obolibrary.org/obo/MP_0010283 decreased classified tumor incidence less than the expected number of neoplasms of the cells usually found in glandular epithelium as a thin layer above the basement membrane but generally beneath the luminal cells, in a given population in a given time period http://purl.obolibrary.org/obo/MP_0012430 decreased Type B reticulum cell tumor incidence http://purl.obolibrary.org/obo/MP_0012420 decreased hemolymphoid system tumor incidence less than the expected number of neoplasms derived from reticulum cells in a given population in a given time period; type B neoplasms are tumors of mixed cellularity of reticulum cells, lymphocytes, plasma cells, eosinophils, and neutrophils http://purl.obolibrary.org/obo/MP_0012432 decreased prostate gland tumor incidence http://purl.obolibrary.org/obo/MP_0012416 decreased gland tumor incidence less than the expected number of neoplams in the prostate gland occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0012433 decreased ovarian tumor incidence http://purl.obolibrary.org/obo/MP_0012417 decreased reproductive system tumor incidence less than the expected number of neoplams in the ovary occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0012434 decreased intestinal adenoma incidence http://purl.obolibrary.org/obo/MP_0012424 decreased alimentary system tumor incidence less than the expected number of a benign epithelial neoplasm with a glandular organization arising in the small and/or large intestine, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0012435 decreased colon tumor incidence http://purl.obolibrary.org/obo/MP_0012424 decreased alimentary system tumor incidence less than the expected number of neoplasms in the colon, usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0012437 increased Harderian gland tumor incidence http://purl.obolibrary.org/obo/MP_0010288 increased gland tumor incidence greater than the expected number of neoplams in the Harderian gland, usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0012438 decreased Harderian gland tumor incidence http://purl.obolibrary.org/obo/MP_0012416 decreased gland tumor incidence less than the expected number of neoplams in the Harderian gland, usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0012439 decreased pituitary gland tumor incidence http://purl.obolibrary.org/obo/MP_0012416 decreased gland tumor incidence less than the expected number of neoplams in the pituitary gland, usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0012443 increased corpus callosum size http://purl.obolibrary.org/obo/MP_0000780 abnormal corpus callosum morphology larger thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres http://purl.obolibrary.org/obo/MP_0012447 thick cerebellar granule layer http://purl.obolibrary.org/obo/MP_0000886 abnormal cerebellar granule layer morphology increased thickness of the innermost cortical layer of the cerebellum that contains granule cells http://purl.obolibrary.org/obo/MP_0012448 abnormal primary motor cortex morphology http://purl.obolibrary.org/obo/MP_0000799 abnormal precentral gyrus morphology any structural anomaly of the part of the cerebral cortex that receives projections from the motor thalamus and which projects to motor neurons in the brainstem and spinal cord; the primary motor cortex, or M1, is located on the precentral gyrus and on the anterior paracentral lobule on the medial surface of the brain http://purl.obolibrary.org/obo/MP_0012449 increased primary motor cortex size http://purl.obolibrary.org/obo/MP_0012448 abnormal primary motor cortex morphology greater size of the part of the cerebral cortex that receives projections from the motor thalamus and which projects to motor neurons in the brainstem and spinal cord http://purl.obolibrary.org/obo/MP_0012450 decreased primary motor cortex size http://purl.obolibrary.org/obo/MP_0012448 abnormal primary motor cortex morphology reduced size of the part of the cerebral cortex that receives projections from the motor thalamus and which projects to motor neurons in the brainstem and spinal cord http://purl.obolibrary.org/obo/MP_0012451 abnormal retrosplenial granular cortex morphology http://purl.obolibrary.org/obo/MP_0012489 abnormal retrosplenial region morphology any structural anomaly of the subregion consisting of two divisions of the retrosplenial cotex, retrosplenial granular cortex A(Rga) and retrosplenial granular cortex B (Rgb), which receive dense projections from the hippocampal formation http://purl.obolibrary.org/obo/MP_0012452 increased retrosplenial granular cortex size http://purl.obolibrary.org/obo/MP_0012451 abnormal retrosplenial granular cortex morphology greater size of the subregion consisting of two divisions of the retrosplenial cotex, retrosplenial granular cortex A(Rga) and retrosplenial granular cortex B (Rgb), which receive dense projections from the hippocampal formation http://purl.obolibrary.org/obo/MP_0012453 decreased retrosplenial granular cortex size http://purl.obolibrary.org/obo/MP_0012451 abnormal retrosplenial granular cortex morphology reduced size of the subregion consisting of two divisions of the retrosplenial cotex, retrosplenial granular cortex A(Rga) and retrosplenial granular cortex B (Rgb), which receive dense projections from the hippocampal formation http://purl.obolibrary.org/obo/MP_0012454 abnormal mammillothalamic tract morphology http://purl.obolibrary.org/obo/MP_0000778 abnormal nervous system tract morphology any structural anomaly of the bundle of nerve fibers that projects from the mammillary body in the posterior hypothalamic region to the anterior nucleus of the thalamus http://purl.obolibrary.org/obo/MP_0012455 increased mammillothalamic tract size http://purl.obolibrary.org/obo/MP_0012454 abnormal mammillothalamic tract morphology greater size of the bundle of nerve fibers that projects from the mammillary body in the posterior hypothalamic region to the anterior nucleus of the thalamus http://purl.obolibrary.org/obo/MP_0012456 dereased mammillothalamic tract size http://purl.obolibrary.org/obo/MP_0012454 abnormal mammillothalamic tract morphology reduced size of the bundle of nerve fibers that projects from the mammillary body in the posterior hypothalamic region to the anterior nucleus of the thalamus http://purl.obolibrary.org/obo/MP_0012457 increased hippocampus pyramidal cell length http://purl.obolibrary.org/obo/MP_0009940 abnormal hippocampus pyramidal cell morphology increased length of a multipolar projection neuron in the hippocampus pyramidal cell layer http://purl.obolibrary.org/obo/MP_0012458 decreased hippocampus pyramidal cell length http://purl.obolibrary.org/obo/MP_0009940 abnormal hippocampus pyramidal cell morphology reduced length of a multipolar projection neuron in the hippocampus pyramidal cell layer http://purl.obolibrary.org/obo/MP_0012459 increased dentate gyrus size http://purl.obolibrary.org/obo/MP_0000812 abnormal dentate gyrus morphology greater size of one of two interlocking gyri of the hippocampus formation that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus http://purl.obolibrary.org/obo/MP_0012460 decreased dentate gyrus size http://purl.obolibrary.org/obo/MP_0000812 abnormal dentate gyrus morphology reduced size of one of two interlocking gyri of the hippocampus formation that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus http://purl.obolibrary.org/obo/MP_0012461 increased brain internal capsule size http://purl.obolibrary.org/obo/MP_0008128 abnormal brain internal capsule morphology greater size of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord http://purl.obolibrary.org/obo/MP_0012462 decreased brain internal capsule size http://purl.obolibrary.org/obo/MP_0008128 abnormal brain internal capsule morphology reduced size of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord http://purl.obolibrary.org/obo/MP_0012463 increased optic tract size http://purl.obolibrary.org/obo/MP_0004267 abnormal optic tract morphology greater size of the paired bands of optic nerve fibers running from the optic chiasma mostly to the lateral geniculate body, with a smaller number of fibers terminating in the superior colliculus and the pretectal region http://purl.obolibrary.org/obo/MP_0012464 decreased optic tract size http://purl.obolibrary.org/obo/MP_0004267 abnormal optic tract morphology reduced size of the paired bands of optic nerve fibers running from the optic chiasma mostly to the lateral geniculate body, with a smaller number of fibers terminating in the superior colliculus and the pretectal region http://purl.obolibrary.org/obo/MP_0012465 increased hippocampal fimbria size http://purl.obolibrary.org/obo/MP_0003005 abnormal hippocampal fimbria morphology greater size of the flattened band of efferent fibers arising from the subiculum and medial border of the hippocampus, which then thickens to form the fornix and fibers of the hippocampal commissure http://purl.obolibrary.org/obo/MP_0012466 decreased hippocampal fimbria size http://purl.obolibrary.org/obo/MP_0003005 abnormal hippocampal fimbria morphology reduced size of the flattened band of efferent fibers arising from the subiculum and medial border of the hippocampus, which then thickens to form the fornix and fibers of the hippocampal commissure http://purl.obolibrary.org/obo/MP_0012467 increased striatum area http://purl.obolibrary.org/obo/MP_0004077 abnormal striatum morphology greater size of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking http://purl.obolibrary.org/obo/MP_0012468 decreased striatum area http://purl.obolibrary.org/obo/MP_0004077 abnormal striatum morphology reduced size of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking http://purl.obolibrary.org/obo/MP_0012469 increased genu of the facial nerve size http://purl.obolibrary.org/obo/MP_0001071 abnormal facial nerve morphology greater size of the bend in the facial nerve at the lateral end of the internal acoustic meatus http://purl.obolibrary.org/obo/MP_0012470 decreased genu of the facial nerve size http://purl.obolibrary.org/obo/MP_0001071 abnormal facial nerve morphology reduced size of the bend in the facial nerve at the lateral end of the internal acoustic meatus http://purl.obolibrary.org/obo/MP_0012471 increased cerebellum interpositus nucleus size http://purl.obolibrary.org/obo/MP_0009984 abnormal cerebellum interpositus nucleus morphology greater size of the nucelus composed of the globose and emoliform nuclei of the cerebellum; in some mammalian species the globose nucleus is not distinguishable http://purl.obolibrary.org/obo/MP_0012472 decreased cerebellum interpositus nucleus size http://purl.obolibrary.org/obo/MP_0009984 abnormal cerebellum interpositus nucleus morphology reduced size of the nucelus composed of the globose and emoliform nuclei of the cerebellum; in some mammalian species the globose nucleus is not distinguishable http://purl.obolibrary.org/obo/MP_0012473 increased cingulate cortex size http://purl.obolibrary.org/obo/MP_0004167 abnormal cingulate gyrus morphology greater size of the thick belt of cortex encircling the corpus callosum that responsible for producing emotional responses to physical sensations of pain and for cognitive control http://purl.obolibrary.org/obo/MP_0012474 decreased cingulate cortex size http://purl.obolibrary.org/obo/MP_0004167 abnormal cingulate gyrus morphology reduced size of the thick belt of cortex encircling the corpus callosum that responsible for producing emotional responses to physical sensations of pain and for cognitive control http://purl.obolibrary.org/obo/MP_0012475 increased piriform cortex size http://purl.obolibrary.org/obo/MP_0010009 abnormal piriform cortex morphology increased size of the subdivision of the laminated olfactory cortex with only three main layers that receive monosynaptic input from the olfactory bulb via the lateral olfactory tract http://purl.obolibrary.org/obo/MP_0012476 decreased piriform cortex size http://purl.obolibrary.org/obo/MP_0010009 abnormal piriform cortex morphology reduced size of the subdivision of the laminated olfactory cortex with only three main layers that receive monosynaptic input from the olfactory bulb via the lateral olfactory tract http://purl.obolibrary.org/obo/MP_0012477 increased secondary somatosensory cortex size http://purl.obolibrary.org/obo/MP_0000863 abnormal secondary somatosensory cortex morphology greater size of the area of the upper bank of the lateral sulcus that is involved in somatic sensation http://purl.obolibrary.org/obo/MP_0012478 decreased secondary somatosensory cortex size http://purl.obolibrary.org/obo/MP_0000863 abnormal secondary somatosensory cortex morphology reduced size of the area of the upper bank of the lateral sulcus that is involved in somatic sensation http://purl.obolibrary.org/obo/MP_0012479 increased amygdala size http://purl.obolibrary.org/obo/MP_0000818 abnormal amygdala morphology greater size of the almond-shaped body of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe; this area is involved in aggression and fear responses http://purl.obolibrary.org/obo/MP_0012480 decreased amygdala size http://purl.obolibrary.org/obo/MP_0000818 abnormal amygdala morphology reduced size of the almond-shaped body of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe; this area is involved in aggression and fear responses http://purl.obolibrary.org/obo/MP_0012481 increased habenula size http://purl.obolibrary.org/obo/MP_0004082 abnormal habenula morphology greater size of the group of nuclei that makes up the small eminence on the dorsomedial surface of the thalamus, just in front of the dorsal commissure on the lateral edge of the habenular trigone http://purl.obolibrary.org/obo/MP_0012482 decreased habenula size http://purl.obolibrary.org/obo/MP_0004082 abnormal habenula morphology reduced size of the group of nuclei that makes up the small eminence on the dorsomedial surface of the thalamus, just in front of the dorsal commissure on the lateral edge of the habenular trigone http://purl.obolibrary.org/obo/MP_0012483 increased corticospinal tract size http://purl.obolibrary.org/obo/MP_0002878 abnormal corticospinal tract morphology greater size of the corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract http://purl.obolibrary.org/obo/MP_0012484 decreased corticospinal tract size http://purl.obolibrary.org/obo/MP_0002878 abnormal corticospinal tract morphology reduced size of the corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract http://purl.obolibrary.org/obo/MP_0012485 increased cochlear VIII nucleus size http://purl.obolibrary.org/obo/MP_0012490 abnormal cochlear VIII nucleus morphology greater size of two paired brainstem nuclei, the dorsal cochlear nucleus and the ventral cochlear nucleus, that lie dorsal and ventral, respectively, to the inferior cerebellar peduncle at the rostral pole of the medulla; the cochlear nuclei receive input from the cochlear nerve and send projections to the inferior colliculus, the medial geniculate, and other forebrain structures http://purl.obolibrary.org/obo/MP_0012486 decreased cochlear VIII nucleus size http://purl.obolibrary.org/obo/MP_0012490 abnormal cochlear VIII nucleus morphology reduced size of two paired brainstem nuclei, the dorsal cochlear nucleus and the ventral cochlear nucleus, that lie dorsal and ventral, respectively, to the inferior cerebellar peduncle at the rostral pole of the medulla; the cochlear nuclei receive input from the cochlear nerve and send projections to the inferior colliculus, the medial geniculate, and other forebrain structures http://purl.obolibrary.org/obo/MP_0012487 increased cerebellum dentate nucleus size http://purl.obolibrary.org/obo/MP_0009980 abnormal cerebellum dentate nucleus morphology greater size of the largest and most lateral of the deep cerebellum nuclei; it receives axons of Purkinje cells in the lateral cerebellar hemisphere (neocerebellum) and receives its afferents from the premotor cortex and the supplementary motor cortex through the pontocerebellar system, and its efferents project through the superior cerebellar peduncle and is a major source of its fibers http://purl.obolibrary.org/obo/MP_0012488 decreased cerebellum dentate nucleus size http://purl.obolibrary.org/obo/MP_0009980 abnormal cerebellum dentate nucleus morphology reduced size of the largest and most lateral of the deep cerebellum nuclei; it receives axons of Purkinje cells in the lateral cerebellar hemisphere (neocerebellum) and receives its afferents from the premotor cortex and the supplementary motor cortex through the pontocerebellar system, and its efferents project through the superior cerebellar peduncle and is a major source of its fibers http://purl.obolibrary.org/obo/MP_0012489 abnormal retrosplenial region morphology http://purl.obolibrary.org/obo/MP_0004167 abnormal cingulate gyrus morphology any structural anomaly of one of the key brain regions required for cognitive functions, including episodic memory, navigation, imagination and planning for the future; the retrosplenial region can be divided into three parts, the retrosplenial granular cortex A, the retrosplenial granular cortex B and the retrosplenial dysgranular cortex; each subdivision of the retrosplenial cortex projects to a discrete terminal field in the hippocampal formation http://purl.obolibrary.org/obo/MP_0012490 abnormal cochlear VIII nucleus morphology http://purl.obolibrary.org/obo/MP_0005277 abnormal brainstem morphology any structural anomaly of two paired brainstem nuclei, the dorsal cochlear nucleus and the ventral cochlear nucleus, that lie dorsal and ventral, respectively, to the inferior cerebellar peduncle at the rostral pole of the medulla; the cochlear nuclei receive input from the cochlear nerve and send projections to the inferior colliculus, the medial geniculate, and other forebrain structures http://purl.obolibrary.org/obo/MP_0012491 larynx stenosis http://purl.obolibrary.org/obo/MP_0002249 abnormal larynx morphology abnormal narrowing or constriction of the organ of voice production located between the pharynx and the trachea http://purl.obolibrary.org/obo/MP_0012492 pharyngeal arch artery hypoplasia http://purl.obolibrary.org/obo/MP_0002672 abnormal pharyngeal arch artery morphology underdevelopment or reduced size of the vessels formed within the six (five in mammals) pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels http://purl.obolibrary.org/obo/MP_0012493 absent pharyngeal arch arteries http://purl.obolibrary.org/obo/MP_0002672 abnormal pharyngeal arch artery morphology absence of the vessels formed within the six (five in mammals) pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels http://purl.obolibrary.org/obo/MP_0012494 dilated pharyngeal arch arteries http://purl.obolibrary.org/obo/MP_0002672 abnormal pharyngeal arch artery morphology stretched or widened aperture of the luminal space of the vessels formed within the six (five in mammals) pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels http://purl.obolibrary.org/obo/MP_0012495 pharyngeal arch artery stenosis http://purl.obolibrary.org/obo/MP_0002672 abnormal pharyngeal arch artery morphology diffuse constriction or narrowing of the vessels formed within the six (five in mammals) pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels http://purl.obolibrary.org/obo/MP_0012496 abnormal pleuropericardial membrane morphology http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology any structural anomaly of the membrane formed by the paired folds that grow out from the lateral part of the body wall; the folds fuse and meet with the dorsal and ventral mesentery of the foregut, separating the pleural cavities from the pericardial cavity http://purl.obolibrary.org/obo/MP_0012497 absent pleuropericardial membrane http://purl.obolibrary.org/obo/MP_0012496 abnormal pleuropericardial membrane morphology absence of the membrane formed by the paired folds that grow out from the lateral part of the body wall; the folds fuse and meet with the dorsal and ventral mesentery of the foregut, separating the pleural cavities from the pericardial cavity http://purl.obolibrary.org/obo/MP_0012498 abnormal cardiogenic plate morphology http://purl.obolibrary.org/obo/MP_0002925 abnormal cardiovascular development any structural anomaly of the splanchnic mesodermal thickening which forms cranial and lateral to the developing neural plate; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube http://purl.obolibrary.org/obo/MP_0012499 absent cardiogenic plate http://purl.obolibrary.org/obo/MP_0012498 abnormal cardiogenic plate morphology absence of the splanchnic mesodermal thickening which forms cranial and lateral to the developing neural plate; normally, angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube http://purl.obolibrary.org/obo/MP_0012500 abnormal angioblastic cord morphology http://purl.obolibrary.org/obo/MP_0002925 abnormal cardiovascular development any structural anomaly of the cordlike masses of splanchnic mesenchymal cells ventral to the primordial pericardial coelom that arrange themselves side by side to form the primordia of the endocardial heart tubes http://purl.obolibrary.org/obo/MP_0012502 decreased hindbrain apoptosis http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology decrease in the number of cells of the hindbrain undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0012503 increased midbrain apoptosis http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology increase in the number of cells of the midbrain undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0012504 increased forebrain apoptosis http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology increase in the number of cells of the forebrain undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0012505 increased neural tube apoptosis http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology increase in the number of cells of the neural tube undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0012506 brain atrophy http://purl.obolibrary.org/obo/MP_0002152 abnormal brain morphology acquired diminution of the size of the brain associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0012507 midbrain atrophy http://purl.obolibrary.org/obo/MP_0012506 brain atrophy acquired diminution of the size of the midbrain associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0012508 forebrain atrophy http://purl.obolibrary.org/obo/MP_0012506 brain atrophy acquired diminution of the size of the forebrain associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0012509 neural tube degeneration http://purl.obolibrary.org/obo/MP_0002151 abnormal neural tube morphology/development a retrogressive impairment of function or destruction of the hollow epithelial tube found on the dorsal side of the vertebrate embryo that develops into the central nervous system (i.e. brain and spinal cord) http://purl.obolibrary.org/obo/MP_0012510 abnormal aortic sac morphology http://purl.obolibrary.org/obo/MP_0002925 abnormal cardiovascular development any structural abnormality of the dilated structure that is lined by endothelial cells and located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates http://purl.obolibrary.org/obo/MP_0012511 dilated aortic sac http://purl.obolibrary.org/obo/MP_0012510 abnormal aortic sac morphology abnormally stretched or widened aperture of the luminal space of the endothelial lined dilation that is located at the arterial pole of the heart just above (distal to) the truncus arteriosus in mammalian embryos; it is the primordial vascular channel from which the aortic arches (and eventually the dorsal aortae) arise; the aortic sac is homologous to the ventral aorta of gill-bearing vertebrates http://purl.obolibrary.org/obo/MP_0012512 abnormal sternum body morphology http://purl.obolibrary.org/obo/MP_0000157 abnormal sternum morphology any structural anomaly of the middle and longest portion of the sternum, lying between the manubrium superiorly and the xiphoid process inferiorly; the body of the sternum (gladiolus), is considerably lengthier, narrower, and thinner than the manubrium, attaining its greatest breadth close to the lower end http://purl.obolibrary.org/obo/MP_0012513 absent sternum body http://purl.obolibrary.org/obo/MP_0012512 abnormal sternum body morphology absence of the middle and longest portion of the sternum, lying between the manubrium superiorly and the xiphoid process inferiorly; the body of the sternum (gladiolus) is considerably lengthier, narrower, and thinner than the manubrium, attaining its greatest breadth close to the lower end http://purl.obolibrary.org/obo/MP_0012514 pectus excavatum http://purl.obolibrary.org/obo/MP_0004134 abnormal chest morphology a caved-in or sunken appearance of the anterior chest wall; the congenital deformity can either be present at birth or may not be visible until puberty http://purl.obolibrary.org/obo/MP_0012515 abnormal heart apex morphology http://purl.obolibrary.org/obo/MP_0000266 abnormal heart morphology any structural anomaly of the lowest superficial part of the heart, normally directed downward, forward, and to the left, and overlapped by the left lung and pleura; the heart apex is formed by the inferolateral part of the left ventricle and responsible for regulating ventricle contraction http://purl.obolibrary.org/obo/MP_0012516 absent metencephalon http://purl.obolibrary.org/obo/MP_0000847 abnormal metencephalon morphology absence of the anterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain normally composed of the cerebellum and the pons Varolii http://purl.obolibrary.org/obo/MP_0012517 absent diencephalon http://purl.obolibrary.org/obo/MP_0000830 abnormal diencephalon morphology absence or loss of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex http://purl.obolibrary.org/obo/MP_0012518 abnormal Brunner's gland morphology http://purl.obolibrary.org/obo/MP_0002163 abnormal gland morphology any structural anomaly of the branched acinotubular glands found in the submucosa of the duodenum located above the Sphincter of Oddi; their main function is to produce a mucus-rich alkaline secretion (containing bicarbonate) to protect the duodenum from the acidic content of chyme, provide an alkaline condition for the intestinal enzymes to be active (thus enabling absorption to take place), and lubricate the intestinal walls; they also secrete urogastrone, which inhibits parietal and chief cells of the stomach from secreting acid and their digestive enzymes http://purl.obolibrary.org/obo/MP_0012519 dilated Brunner's glands http://purl.obolibrary.org/obo/MP_0012518 abnormal Brunner's gland morphology stretched or widened aperture of the luminal space of the branched acinotubular glands found in the submucosa of the duodenum located above the Sphincter of Oddi; their main function is to produce a mucus-rich alkaline secretion (containing bicarbonate) to protect the duodenum from the acidic content of chyme, provide an alkaline condition for the intestinal enzymes to be active (thus enabling absorption to take place), and lubricate the intestinal walls; they also secrete urogastrone, which inhibits parietal and chief cells of the stomach from secreting acid and their digestive enzymes http://purl.obolibrary.org/obo/MP_0012520 absent Brunner's glands http://purl.obolibrary.org/obo/MP_0012518 abnormal Brunner's gland morphology absence of the branched acinotubular glands found in the submucosa of the duodenum located above the Sphincter of Oddi; their main function is to produce a mucus-rich alkaline secretion (containing bicarbonate) to protect the duodenum from the acidic content of chyme, provide an alkaline condition for the intestinal enzymes to be active (thus enabling absorption to take place), and lubricate the intestinal walls; they also secrete urogastrone, which inhibits parietal and chief cells of the stomach from secreting acid and their digestive enzymes http://purl.obolibrary.org/obo/MP_0012521 abnormal buccopharyngeal membrane morphology http://purl.obolibrary.org/obo/MP_0003119 abnormal digestive system development any structural anomaly of the thin bilaminar membrane derived from the prechordal plate that is devoid of mesoderm and formed by the apposition of the stomodeal ectoderm with the foregut endoderm; after the embryonic head fold has evolved it lies at the caudal limit of the stomodeum, forming a septum between the primitive mouth and pharynx; the membrane eventually disappears, and thus a communication is established between the mouth and the future pharynx http://purl.obolibrary.org/obo/MP_0012522 abnormal stomodeum morphology http://purl.obolibrary.org/obo/MP_0003119 abnormal digestive system development any structural anomaly of the primordial mouth region of the developing head, initially a midline ectodermal depression between the forebrain bulge (cranially) and the heart bulge (caudally) and between the maxillary and mandibular components of the first pharyngeal arch; the stomodeum is separated from the anterior end of the foregut by the buccopharyngeal membrane; the mouth is developed partly from the stomodeum, and partly from the floor of the anterior portion of the foregut; the lips, teeth, and gums are formed from the walls of the stomodeum, but the tongue is developed in the floor of the pharynx http://purl.obolibrary.org/obo/MP_0012524 abnormal lower lip morphology http://purl.obolibrary.org/obo/MP_0003769 abnormal lip morphology any structural anomaly of the muscular fold bounding the opening of the mouth inferiorly http://purl.obolibrary.org/obo/MP_0012525 abnormal rhombic lip morphology http://purl.obolibrary.org/obo/MP_0000913 abnormal brain development any structural anomaly of the posterior section of the developing metencephalon recognized transiently within the vertebrate embryo; the rhombic lip extends posteriorly from the roof of the fourth ventricle to dorsal neuroepithelial cell and can be divided into eight structural units based on rhombomeres 1-8 (r1-r8), recognized at early stages of hindbrain development; producing granule cells and five brainstem nuclei, the rhombic lip plays an important role in developing a complex cerebellar neural system http://purl.obolibrary.org/obo/MP_0012526 abnormal upper rhombic lip morphology http://purl.obolibrary.org/obo/MP_0012525 abnormal rhombic lip morphology any structural anomaly of the anterior-most region of dorsal hindbrain within rhombomere 1, adjacent the midbrain-hindbrain boundary http://purl.obolibrary.org/obo/MP_0012527 abnormal lower rhombic lip morphology http://purl.obolibrary.org/obo/MP_0012525 abnormal rhombic lip morphology any structural anomaly of the posterior portion of the rhombic lip contained within rhombomeres 2-8 which gives rise to several brainstem nuclei and the choroid plexus http://purl.obolibrary.org/obo/MP_0012528 abnormal zone of polarizing activity morphology http://purl.obolibrary.org/obo/MP_0005650 abnormal limb bud morphology any structural anomaly of the subset of cells found in the posterior mesenchyme region of the vertebrate limb bud; Sonic hedgehog (Shh) produced by ZPA represents the key mediator of the polarizing activity that regulates patterning of the limb along the anterio-posterior (A-P) axis http://purl.obolibrary.org/obo/MP_0012529 abnormal decidua basalis morphology http://purl.obolibrary.org/obo/MP_0004256 abnormal maternal decidual layer morphology any structural anomaly of the area of uterine endometrium found between the implanted chorionic vesicle and the myometrium; with continued growth of the embryo, the decidua basalis becomes incorporated into the maternal component of the definitive placenta http://purl.obolibrary.org/obo/MP_0012530 abnormal decidua capsularis morphology http://purl.obolibrary.org/obo/MP_0004256 abnormal maternal decidual layer morphology any structural anomaly of the layer of uterine endometrium overlying the implanted chorionic vesicle and facing the uterine cavity http://purl.obolibrary.org/obo/MP_0012531 delayed limb development http://purl.obolibrary.org/obo/MP_0006279 abnormal limb development late onset of the induction and/or differentiation of the limbs http://purl.obolibrary.org/obo/MP_0012532 abnorrmal surface ectoderm morphology http://purl.obolibrary.org/obo/MP_0001675 abnormal ectoderm development any structural anomaly of the surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm; cells from the surface ectoderm differentiate to form the epidermis; epithelia lining the mouth and nasal cavities; hair follicles and nails; the lacrimal, tarsal, salivary, sebaceous, sweat, and mammary glands, and anterior pituitary gland (adenohypophysis); inner and outer ear structures; the lens, and conjunctival and corneal epithelia; dental enamel; and the apical ectodermal ridge inducing development of the limb buds http://purl.obolibrary.org/obo/MP_0012534 abnormal optic fissure morphology http://purl.obolibrary.org/obo/MP_0001286 abnormal eye development any structural anomaly of the ventral groove formed by invagination of the optic cup and its stalk by vascular mesenchyme from which the hyaloid vessels develop; a transient gap in the ventral margin of the developing optic cup that eventually closes to complete the eye wall inferiorly and enclose the hyaloid vessels in a canal in the optic stalk http://purl.obolibrary.org/obo/MP_0012535 abnormal optic fissure closure http://purl.obolibrary.org/obo/MP_0001286 abnormal eye development failure to initiate and/or complete closure of the transient gap in the ventral margin of the developing optic cup; fusion of the optic fissure begins with apposition of the inferior lips of the ventral-most optic cup and continues anteriorly toward its rim and posteriorly along the optic stalk; failure or late closure of the optic fissure prevents the establishment of normal fetal intraocular pressure and can result in microphthalmia associataed with colobomas http://purl.obolibrary.org/obo/MP_0012536 delayed optic fissure closure http://purl.obolibrary.org/obo/MP_0012535 abnormal optic fissure closure late onset of the initiation and/or completion of closure of the transient gap in the ventral margin of the developing optic cup; fusion of the optic fissure begins with apposition of the inferior lips of the ventral-most optic cup and continues anteriorly toward its rim and posteriorly along the optic stalk http://purl.obolibrary.org/obo/MP_0012537 abnormal hyaloid artery morphology http://purl.obolibrary.org/obo/MP_0001286 abnormal eye development any structural anomaly of the artery which arises from the dorsal ophthalmic artery and enters the eye cup through the optic (choroid) fissure; the hyaloid artery is contained within the optic stalk of the eye, extends from the optic disc through the vitreous humor to the lens, and serves to supply nutrients to the developing lens in the growing fetus; it usually regresses (around 2 weeks after birth in mice and before birth in humans), with its proximal portion remaining as the central artery of the retina; regression of the hyaloid artery leaves a clear central zone through the vitreous humor, called the hyaloid canal or Cloquet's canal http://purl.obolibrary.org/obo/MP_0012538 persistent hyaloid artery http://purl.obolibrary.org/obo/MP_0012537 abnormal hyaloid artery morphology incomplete regression of the hyaloid artery, usually accompanied by persistence of the hyperplastic primary vitreous; small remnants of the artery may remain with free remnants sometimes seen as floating material (aka muscae volitantes); an anterior remnant of the hyaloid artery can be seen as Mittendorf's dot, a small pinpoint-like scar on the posterior surface of the lens; a posterior remnant may be seen where the artery left the optic disc, and is known as Bergmeister's papilla http://purl.obolibrary.org/obo/MP_0012539 Bergmeister's papilla http://purl.obolibrary.org/obo/MP_0012538 persistent hyaloid artery a posterior remnant of the fetal hyaloid artery that arises from the center of the optic disc and consists of a small tuft of fibrous tissue http://purl.obolibrary.org/obo/MP_0012540 abnormal lamina terminalis morphology http://purl.obolibrary.org/obo/MP_0002151 abnormal neural tube morphology/development any structural anomaly of the anterior-most (rostral) portion of the wall of the neural tube, formed by closure of the anterior neuropore; the median strip of the anterior wall of the prosencephalon, which persists in a relatively unchanged state as the cerebral hemispheres grow out forward beyond the original anterior end of the prosencephalon; in the developed brain, the lamina terminalis remains as the thin rostral wall of the third ventricle, stretching from the bases of the major cerebral commissures (the anterior commissure, the commissure of the fornix, and the rostrum of the corpus callosum) to the dorsal surface of the optic chiasm http://purl.obolibrary.org/obo/MP_0012541 absent lamina terminalis http://purl.obolibrary.org/obo/MP_0012540 abnormal lamina terminalis morphology absence of the anterior-most (rostral) portion of the wall of the neural tube, formed by closure of the anterior neuropore; agenesis of the lamina terminalis results in anencephaly http://purl.obolibrary.org/obo/MP_0012542 abnormal neuropore morphology http://purl.obolibrary.org/obo/MP_0002151 abnormal neural tube morphology/development any structural anomaly of either the anterior or posterior temporary opening leading from the central canal of the embryonic neural tube to the exterior; the anterior and posterior neuropores connect the lumen of the neural tube with the amniotic cavity http://purl.obolibrary.org/obo/MP_0012544 abnormal caudal neuropore morphology http://purl.obolibrary.org/obo/MP_0012542 abnormal neuropore morphology any structural anomaly of the temporary opening at the extreme caudal end of the neural tube in early embryos; the posterior neuropore appears before the process of neural tube closure is complete http://purl.obolibrary.org/obo/MP_0012545 syringomyelia http://purl.obolibrary.org/obo/MP_0000955 abnormal spinal cord morphology a condition whereby a fluid-filled cyst or cavity (syrinx) develops within the spinal cord http://purl.obolibrary.org/obo/MP_0012546 triangular face http://purl.obolibrary.org/obo/MP_0003743 abnormal facial morphology a face whose lower half becomes relatively thin, approaching an appearance of a triangle with a tip facing downwards; usually associated with a prominent forehead and micrognathia http://purl.obolibrary.org/obo/MP_0012548 myelocele http://purl.obolibrary.org/obo/MP_0012547 spina bifida cystica hernial protrusion of the spinal cord through an opening or defect in the vertebral column http://purl.obolibrary.org/obo/MP_0012549 hypoxemia http://purl.obolibrary.org/obo/MP_0002329 abnormal blood gas level subnormal arterial oxygen tension; deficient oxygenation of arterial blood http://purl.obolibrary.org/obo/MP_0012550 respiratory acidosis http://purl.obolibrary.org/obo/MP_0003031 acidosis acidosis caused by retention of and increased blood carbon dioxide concentration, often caused by decreased ventilation (hypoventilation); results in decreased blood pH unless kidneys compensate by retaining bicarbonate http://purl.obolibrary.org/obo/MP_0012551 metabolic acidosis http://purl.obolibrary.org/obo/MP_0003031 acidosis decreased pH and bicarbonate concentration in tissues and/or body fluids caused when the body produces too much acid or when the kidneys are not removing enough acid from the body, as in diarrhea or in kidney disease http://purl.obolibrary.org/obo/MP_0012552 lactic acidosis http://purl.obolibrary.org/obo/MP_0012551 metabolic acidosis a form of acidosis in which an accumulation of lactic acid in tissues occurs; causes include tissue hypoxia and drug effects http://purl.obolibrary.org/obo/MP_0012553 decreased serum complement activity http://purl.obolibrary.org/obo/MP_0002471 abnormal complement pathway decreased ability of the complement proteins to act sequentially to directly kill microbes, dispose of immune complexes, and regulate other immune processes http://purl.obolibrary.org/obo/MP_0012554 increased serum complement activity http://purl.obolibrary.org/obo/MP_0002471 abnormal complement pathway increased ability of the complement proteins to act sequentially to directly kill microbes, dispose of immune complexes, and regulate other immune processes http://purl.obolibrary.org/obo/MP_0012557 decreased calcium uptake by cardiac muscle http://purl.obolibrary.org/obo/MP_0004215 abnormal myocardial fiber physiology decreased directed movement of calcium ions into cardiac muscle; decreased or disrupted uptake may give rise to energetic deficit and oxidative stress. leading to cardiac disease http://purl.obolibrary.org/obo/MP_0012558 increased calcium uptake by cardiac muscle http://purl.obolibrary.org/obo/MP_0004215 abnormal myocardial fiber physiology increased directed movement of calcium ions into the cardiac muscle; increased mitochondrial calcium ion uptake can trigger programmed necrosis in cardiac muscle http://purl.obolibrary.org/obo/MP_0012559 decreased forebrain volume http://purl.obolibrary.org/obo/MP_0012138 decreased forebrain size decrease from the average range of forebrain volume compared to normal http://purl.obolibrary.org/obo/MP_0012560 increased forebrain volume http://purl.obolibrary.org/obo/MP_0012139 increased forebrain size increase from the average range of forebrain volume compared to normal http://purl.obolibrary.org/obo/MP_0012561 decreased foot pad temperature http://purl.obolibrary.org/obo/MP_0005534 decreased body temperature decreased degree of heat natural to the foot pad-environment interface of a living being http://purl.obolibrary.org/obo/MP_0012562 vasculature degeneration http://purl.obolibrary.org/obo/MP_0001614 abnormal blood vessel morphology a retrogressive impairment of function or destruction of the network of tubes that carries blood through the body http://purl.obolibrary.org/obo/MP_0012563 increased tumor incidence following infection http://purl.obolibrary.org/obo/MP_0002021 increased incidence of induced tumors greater than the expected number of neoplasms in a specific population after infection with a pathogen in a given time period, usually of a specific type http://purl.obolibrary.org/obo/MP_0012564 decreased tumor incidence following infection http://purl.obolibrary.org/obo/MP_0002053 decreased incidence of induced tumors less than the expected number of neoplasms in a specific population after infection with a pathogen in a given time period, usually of a specific type http://purl.obolibrary.org/obo/MP_0012565 perivasculitis http://purl.obolibrary.org/obo/MP_0001846 increased inflammatory response inflammation of a perivascular sheath surrounding a blood or lymph vessel, and the surrounding tissue http://purl.obolibrary.org/obo/MP_0012566 decreased susceptibility to experimental autoimmune orchitis http://purl.obolibrary.org/obo/MP_0005351 decreased susceptibility to autoimmune disorder greater likelihood that an organism will develop disease characterized by lymphocytes surrounding the tubuli recti, spermatogenic disturbance and irreversible damage to the seminiferous epithelium http://purl.obolibrary.org/obo/MP_0012567 increased susceptibility to experimental autoimmune orchitis http://purl.obolibrary.org/obo/MP_0005350 increased susceptibility to autoimmune disorder reduced likelihood that an organism will develop disease characterized by lymphocytes surrounding the tubuli recti, spermatogenic disturbance and irreversible damage to the seminiferous epithelium http://purl.obolibrary.org/obo/MP_0012568 decreased mammary gland tumor incidence in breeding females http://purl.obolibrary.org/obo/MP_0010269 decreased mammary gland tumor incidence less than the expected number of neoplams in the mammary gland in female organisms that are actively mating and producing offspring http://purl.obolibrary.org/obo/MP_0012569 decreased mammary gland tumor incidence in virgin females http://purl.obolibrary.org/obo/MP_0010269 decreased mammary gland tumor incidence less than the expected number of neoplams in the mammary gland in female organisms that have never had sexual intercourse http://purl.obolibrary.org/obo/MP_0012570 increased mammary gland tumor incidence in breeding females http://purl.obolibrary.org/obo/MP_0010299 increased mammary gland tumor incidence greater than the expected number of neoplams in the mammary gland in female organisms that are actively mating and producing offspring http://purl.obolibrary.org/obo/MP_0012572 increased susceptibility to chemically induced skin inflammation http://purl.obolibrary.org/obo/MP_0004947 skin inflammation decreased dosage threshold or greater inflammatory response of the skin after topical application of chemical irritants http://purl.obolibrary.org/obo/MP_0012573 decreased susceptibility to chemically induced skin inflammation http://purl.obolibrary.org/obo/MP_0004947 skin inflammation increased dosage threshold, or reduced or no inflammation of the skin after topical application of chemical irritants http://purl.obolibrary.org/obo/MP_0012576 abnormal kidney glutathione peroxidase activity http://purl.obolibrary.org/obo/MP_0011601 abnormal glutathione peroxidase activity anomaly in the ability to catalyze the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O in kidney tissue http://purl.obolibrary.org/obo/MP_0012577 decreased kidney glutathione peroxidase activity http://purl.obolibrary.org/obo/MP_0012576 abnormal kidney glutathione peroxidase activity reduced ability to catalyze the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O in kidney tissue http://purl.obolibrary.org/obo/MP_0012578 increased kidney glutathione peroxidase activity http://purl.obolibrary.org/obo/MP_0012576 abnormal kidney glutathione peroxidase activity increased ability to catalyze the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O in kidney tissue http://purl.obolibrary.org/obo/MP_0012579 abnormal peroxidase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O http://purl.obolibrary.org/obo/MP_0012580 decreased peroxidase activity http://purl.obolibrary.org/obo/MP_0012579 abnormal peroxidase activity reduced ability to catalyze the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O http://purl.obolibrary.org/obo/MP_0012581 decreased eosinophil peroxidase activity http://purl.obolibrary.org/obo/MP_0012580 decreased peroxidase activity reduced ability to catalyze the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O in eosinophils http://purl.obolibrary.org/obo/MP_0012582 increased peroxidase activity http://purl.obolibrary.org/obo/MP_0012579 abnormal peroxidase activity increased ability to catalyze the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O http://purl.obolibrary.org/obo/MP_0012583 increased eosinophil peroxidase activity http://purl.obolibrary.org/obo/MP_0012582 increased peroxidase activity increased ability to catalyze the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O in eosinophils http://purl.obolibrary.org/obo/MP_0012584 abnormal catechol O-methyltransferase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol http://purl.obolibrary.org/obo/MP_0012585 decreased catechol O-methyltransferase activity http://purl.obolibrary.org/obo/MP_0012584 abnormal catechol O-methyltransferase activity reduction in the ability to catalyze the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol http://purl.obolibrary.org/obo/MP_0012586 increased catechol O-methyltransferase activity http://purl.obolibrary.org/obo/MP_0012584 abnormal catechol O-methyltransferase activity greater ability to catalyze the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol http://purl.obolibrary.org/obo/MP_0012587 decreased brain catechol O-methyltransferase activity http://purl.obolibrary.org/obo/MP_0012585 decreased catechol O-methyltransferase activity reduced ability of brain tissue to catalyze the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol http://purl.obolibrary.org/obo/MP_0012588 increased brain catechol O-methyltransferase activity http://purl.obolibrary.org/obo/MP_0012586 increased catechol O-methyltransferase activity greater ability of brain tissue to catalyze the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol http://purl.obolibrary.org/obo/MP_0012589 abnormal choline O-acetyltransferase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: acetyl-CoA + choline = acetylcholine + CoA http://purl.obolibrary.org/obo/MP_0012590 decreased choline O-acetyltransferase activity http://purl.obolibrary.org/obo/MP_0012589 abnormal choline O-acetyltransferase activity reduction in the ability to catalyze the reaction: acetyl-CoA + choline = acetylcholine + CoA http://purl.obolibrary.org/obo/MP_0012591 increased choline O-acetyltransferase activity http://purl.obolibrary.org/obo/MP_0012589 abnormal choline O-acetyltransferase activity greater ability to catalyze the reaction: acetyl-CoA + choline = acetylcholine + CoA http://purl.obolibrary.org/obo/MP_0012592 decreased brain choline acetyltransferase activity http://purl.obolibrary.org/obo/MP_0012590 decreased choline O-acetyltransferase activity reduced ability of the brain to catalyze the reaction: acetyl-CoA + choline = acetylcholine + CoA http://purl.obolibrary.org/obo/MP_0012593 increased brain choline acetyltransferase activity http://purl.obolibrary.org/obo/MP_0012591 increased choline O-acetyltransferase activity greater ability of the brain to catalyze the reaction: acetyl-CoA + choline = acetylcholine + CoA http://purl.obolibrary.org/obo/MP_0012594 abnormal glutamate decarboxylase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: L-glutamate = 4-aminobutanoate + CO2 http://purl.obolibrary.org/obo/MP_0012595 decreased glutamate decarboxylase activity http://purl.obolibrary.org/obo/MP_0012594 abnormal glutamate decarboxylase activity reduction in the ability to catalyze the reaction: L-glutamate = 4-aminobutanoate + CO2 http://purl.obolibrary.org/obo/MP_0012596 increased glutamate decarboxylase activity http://purl.obolibrary.org/obo/MP_0012594 abnormal glutamate decarboxylase activity greater ability to catalyze the reaction: L-glutamate = 4-aminobutanoate + CO2 http://purl.obolibrary.org/obo/MP_0012597 abnormal nicotinamide N-methyltransferase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine http://purl.obolibrary.org/obo/MP_0012598 decreased nicotinamide N-methyltransferase activity http://purl.obolibrary.org/obo/MP_0012597 abnormal nicotinamide N-methyltransferase activity reduction in the ability to catalyze the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine http://purl.obolibrary.org/obo/MP_0012599 increased nicotinamide N-methyltransferase activity http://purl.obolibrary.org/obo/MP_0012597 abnormal nicotinamide N-methyltransferase activity greater ability to catalyze the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine http://purl.obolibrary.org/obo/MP_0012623 abnormal acetylcholinesterase activity http://purl.obolibrary.org/obo/MP_0020029 abnormal cholinesterase activity anomaly in the catalysis of the reaction: acetylcholine + H2O = choline + acetate http://purl.obolibrary.org/obo/MP_0012624 decreased acetylcholinesterase activity http://purl.obolibrary.org/obo/MP_0020034 decreased cholinesterase activity decreased rate of the catalysis of the reaction: acetylcholine + H2O = choline + acetate http://purl.obolibrary.org/obo/MP_0012625 increased acetylcholinesterase activity http://purl.obolibrary.org/obo/MP_0020033 increased cholinesterase activity increased rate of the catalysis of the reaction: acetylcholine + H2O = choline + acetate http://purl.obolibrary.org/obo/MP_0012626 decreased brain acetylcholinesterase activity http://purl.obolibrary.org/obo/MP_0012624 decreased acetylcholinesterase activity decreased rate of the catalysis of the reaction: acetylcholine + H2O = choline + acetate in the brain http://purl.obolibrary.org/obo/MP_0012627 increased brain acetylcholinesterase activity http://purl.obolibrary.org/obo/MP_0012625 increased acetylcholinesterase activity increased rate of the catalysis of the reaction: acetylcholine + H2O = choline + acetate in the brain http://purl.obolibrary.org/obo/MP_0012635 abnormal monoamine oxidase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2; oxygen is used to remove an amine group from a monoamine, requiring FAD as an enzymatic cofactor, and produces aldehyde and ammonia http://purl.obolibrary.org/obo/MP_0012636 decreased monoamine oxidase activity http://purl.obolibrary.org/obo/MP_0012635 abnormal monoamine oxidase activity reduction in the ability to catalyze the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2; oxygen is used to remove an amine group from a monoamine, requiring FAD as an enzymatic cofactor, and produces aldehyde and ammonia http://purl.obolibrary.org/obo/MP_0012637 increased monoamine oxidase activity http://purl.obolibrary.org/obo/MP_0012635 abnormal monoamine oxidase activity increase in the ability to catalyze the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2; oxygen is used to remove an amine group from a monoamine, requiring FAD as an enzymatic cofactor, and produces aldehyde and ammonia http://purl.obolibrary.org/obo/MP_0012638 decreased brain monoamine oxidase activity http://purl.obolibrary.org/obo/MP_0012636 decreased monoamine oxidase activity reduction in the ability to catalyze the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2 in the brain; oxygen is used to remove an amine group from a monoamine, requiring FAD as an enzymatic cofactor, and produces aldehyde and ammonia http://purl.obolibrary.org/obo/MP_0012639 increased brain monoamine oxidase activity http://purl.obolibrary.org/obo/MP_0012637 increased monoamine oxidase activity increase in the ability to catalyze the reaction: RCH2NHR' + H2O + O2 = RCHO + R'NH2 + H2O2 in brain tissue; oxygen is used to remove an amine group from a monoamine, requiring FAD as an enzymatic cofactor, and produces aldehyde and ammonia http://purl.obolibrary.org/obo/MP_0012643 abnormal 5-aminolevulinate synthase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity any anomaly in the ability to catalyze the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA http://purl.obolibrary.org/obo/MP_0012644 decreased 5-aminolevulinate synthase activity http://purl.obolibrary.org/obo/MP_0012643 abnormal 5-aminolevulinate synthase activity reduced ability to catalyze the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA http://purl.obolibrary.org/obo/MP_0012645 increased 5-aminolevulinate synthase activity http://purl.obolibrary.org/obo/MP_0012643 abnormal 5-aminolevulinate synthase activity increased ability to catalyze the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA http://purl.obolibrary.org/obo/MP_0012661 decreased circulating ceruloplasmin level http://purl.obolibrary.org/obo/MP_0005416 abnormal circulating protein level decreased amount in the blood of any of ceruloplasmin, a ferroxidase enzyme http://purl.obolibrary.org/obo/MP_0012662 increased circulating ceruloplasmin level http://purl.obolibrary.org/obo/MP_0005416 abnormal circulating protein level increased amount in the blood of any of ceruloplasmin, a ferroxidase enzyme http://purl.obolibrary.org/obo/MP_0012663 decreased haptoglobin level http://purl.obolibrary.org/obo/MP_0013215 abnormal haptoglobin level decreased amount of haptoglobin, a protein that binds free hemoglobin (Hb) released from erythrocytes with high affinity and thereby inhibits its oxidative activity http://purl.obolibrary.org/obo/MP_0012664 decreased circulating haptoglobin level http://purl.obolibrary.org/obo/MP_0012663 decreased haptoglobin level decreased amount in the blood of any of haptoglobin, a protein that binds free hemoglobin (Hb) released from erythrocytes with high affinity and thereby inhibits its oxidative activity http://purl.obolibrary.org/obo/MP_0012665 increased haptoglobin level http://purl.obolibrary.org/obo/MP_0013215 abnormal haptoglobin level increased amount of any of haptoglobin, a protein that binds free hemoglobin (Hb) released from erythrocytes with high affinity and thereby inhibits its oxidative activity http://purl.obolibrary.org/obo/MP_0012666 increased circulating haptoglobin level http://purl.obolibrary.org/obo/MP_0012665 increased haptoglobin level increased amount in the blood of any of haptoglobin, a protein that binds free hemoglobin (Hb) released from erythrocytes with high affinity and thereby inhibits its oxidative activity http://purl.obolibrary.org/obo/MP_0012667 split sternal manubrium http://purl.obolibrary.org/obo/MP_0008785 abnormal sternum manubrium morphology the appearance of an abnormal division of the cranial most segment of the sternum http://purl.obolibrary.org/obo/MP_0012668 absent sternal manubrium http://purl.obolibrary.org/obo/MP_0008785 abnormal sternum manubrium morphology absence of the cranial most segment of the sternum http://purl.obolibrary.org/obo/MP_0012669 abnormal somite segmentation clock http://purl.obolibrary.org/obo/MP_0001688 abnormal somite development anomaly or loss of the oscillatory mechanism governed by periodic shifts in gene expression and operating in the presomitic mesoderm that drives the regular periodicity with which somites are formed in the course of vertebrate segmentation. The total number of somites formed and the periodicity with which they are produced are species-specific parameters (e.g. humans have 33 somites with a somitogenesis period of approximately 6 hours while mice have 65 somites with a period of approximately 2 hours) http://purl.obolibrary.org/obo/MP_0012670 prolonged somite segmentation clock period http://purl.obolibrary.org/obo/MP_0012669 abnormal somite segmentation clock extension of the somite segmentation clock period; may lead to decreased numbers of somites and their resultant vertebrae http://purl.obolibrary.org/obo/MP_0012671 retinal spots http://purl.obolibrary.org/obo/MP_0001325 abnormal retina morphology the appearance of roundish lesions on the retina, frequently white, and may be due to inflammation, degeneration, vasculitis, exudates, edema or mineral deposits http://purl.obolibrary.org/obo/MP_0012672 enlarged trachea http://purl.obolibrary.org/obo/MP_0002282 abnormal trachea morphology increased size of the tube descending from the larynx and branching into the right and left main bronchi http://purl.obolibrary.org/obo/MP_0012673 aberrant crypt foci http://purl.obolibrary.org/obo/MP_0004842 abnormal large intestine crypts of Lieberkuhn morphology a neoplastic lesion in which large, thick clusters of abnormal tube-like glands are found in the lining of the colon and rectum; aberrant crypt foci are precursors of colorectal polyps, adenoma and colon cancer http://purl.obolibrary.org/obo/MP_0012674 tomacula http://purl.obolibrary.org/obo/MP_0003871 abnormal myelin sheath morphology focal myelin swellings due to redundant folding of myelin sheaths; often sausage-shaped and excessively folded http://purl.obolibrary.org/obo/MP_0012675 enlarged floor plate http://purl.obolibrary.org/obo/MP_0000925 abnormal floor plate morphology increased size of the specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube http://purl.obolibrary.org/obo/MP_0012677 absent brain ventricles http://purl.obolibrary.org/obo/MP_0000822 abnormal brain ventricle morphology absence of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord http://purl.obolibrary.org/obo/MP_0012678 absent fourth ventricle http://purl.obolibrary.org/obo/MP_0000828 abnormal fourth ventricle morphology absence of the irregularly shaped cavity in the rhombencephalon, normally located between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; the fourth ventricle is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space http://purl.obolibrary.org/obo/MP_0012679 absent third ventricle http://purl.obolibrary.org/obo/MP_0000826 abnormal third ventricle morphology absence of the narrow cleft located inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina http://purl.obolibrary.org/obo/MP_0012680 absent lateral ventricles http://purl.obolibrary.org/obo/MP_0000823 abnormal lateral ventricle morphology absence of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; lateral ventricles are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle http://purl.obolibrary.org/obo/MP_0012681 collapsed brain ventricles http://purl.obolibrary.org/obo/MP_0013228 brain ventricle stenosis the luminal space of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord are severely reduced in volume or area, possibly due to reduced or absent cerebrospinal fluid production; collapsed ventricles can be a sign of increased intracranial pressure and accumulation of water in the brain parenchyma http://purl.obolibrary.org/obo/MP_0012682 abnormal septal nucleus morphology http://purl.obolibrary.org/obo/MP_0012003 abnormal septum of telencephalon morphology any structural anomaly of the groups of neural nuclei situated in the septal region which have afferent and cholinergic efferent connections with a variety of forebrain and brainstem areas including the hippocampus, the lateral hypothalamus, the tegmentum, and the amygdala http://purl.obolibrary.org/obo/MP_0012683 absent telencephalon http://purl.obolibrary.org/obo/MP_0000787 abnormal telencephalon morphology absence of the enlarged anteriolateral part of the brain; consists of the paired cerebral hemispheres and olfactory bulbs, the basal ganglia and the connecting structures http://purl.obolibrary.org/obo/MP_0012684 abnormal pleural cavity morphology http://purl.obolibrary.org/obo/MP_0002132 abnormal respiratory system morphology any structural anomaly of the potential space between the two pleurae (visceral and parietal) of the lungs; the pleural cavity, with its associated pleurae, aids optimal functioning of the lungs during breathing; it normally contains a thin film of serous fluid which lubricates the opposed pleural membranes so that they can glide smoothly against one another during ventilation http://purl.obolibrary.org/obo/MP_0012685 abnormal primitive streak elongation http://purl.obolibrary.org/obo/MP_0002231 abnormal primitive streak morphology any anomaly in the process by which the primitive streak extends anteriorly and elongates towards the distal (cranial) end of the embryo to reach its full length http://purl.obolibrary.org/obo/MP_0012686 everted embryonic neuroepithelium http://purl.obolibrary.org/obo/MP_0004261 abnormal embryonic neuroepithelium morphology an inside-out appearance of the embryonic neuroepithelium characteristic of defective primary neurulation resulting from failure of neural fold elevation; everted neural folds assume a convex instead of a concave morphology and fail to bend toward each other and fuse at the dorsal midline leading to exencephaly http://purl.obolibrary.org/obo/MP_0012687 abnormal heart atrium weight http://purl.obolibrary.org/obo/MP_0003105 abnormal heart atrium morphology abnormal average weight of both the left and right atria http://purl.obolibrary.org/obo/MP_0012688 abnormal heart ventricles weight http://purl.obolibrary.org/obo/MP_0005294 abnormal heart ventricle morphology abnormal average weight of both the left and right ventricles together http://purl.obolibrary.org/obo/MP_0012689 abnormal adrenal gland weight http://purl.obolibrary.org/obo/MP_0000639 abnormal adrenal gland morphology abnormal weight of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla http://purl.obolibrary.org/obo/MP_0012690 abnormal stride length http://purl.obolibrary.org/obo/MP_0001406 abnormal gait abnormal average distance between steps http://purl.obolibrary.org/obo/MP_0012691 abnormal acetaminophen metabolism http://purl.obolibrary.org/obo/MP_0008875 abnormal xenobiotic pharmacokinetics altered ability to metabolize acetaminophen, used as a non-narcotic analgesic, a non-steroidal anti-inflammatory and an anti-pyretic agent http://purl.obolibrary.org/obo/MP_0012692 abnormal fluoxetine metabolism http://purl.obolibrary.org/obo/MP_0008875 abnormal xenobiotic pharmacokinetics altered ability to metabolize fluoxetine, an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class which is commonly used to treat various psychiatric disorders http://purl.obolibrary.org/obo/MP_0012693 abnormal haloperidol metabolism http://purl.obolibrary.org/obo/MP_0008875 abnormal xenobiotic pharmacokinetics altered ability to metabolize haloperidol, a butyrophenone-type antipsychotic medication used in the treatment of schizophrenia, acute psychosis, and delirium http://purl.obolibrary.org/obo/MP_0012694 abnormal lithium metabolism http://purl.obolibrary.org/obo/MP_0008875 abnormal xenobiotic pharmacokinetics altered ability to metabolize lithium, commonly used as a mood-stabilizing drug, primarily in the treatment of bipolar disorder in the treatment of both depressive and particularly of mania episodes http://purl.obolibrary.org/obo/MP_0012695 abnormal nicotine metabolism http://purl.obolibrary.org/obo/MP_0008875 abnormal xenobiotic pharmacokinetics altered ability to metabolize nicotine, a potent parasympathomimetic alkaloid that acts as a stimulant in mammals; nicotine activates the mesolimbic pathway in the central nervous system, which regulates feelings of reward and pleasure, and this response is thought to contribute to the addictive nature of nicotine http://purl.obolibrary.org/obo/MP_0012696 abnormal trichloroethylene metabolism http://purl.obolibrary.org/obo/MP_0008875 abnormal xenobiotic pharmacokinetics altered ability to metabolize trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, used as an industrial solvent, and was used a anesthetic and as an inhaled obstetrical analgesic http://purl.obolibrary.org/obo/MP_0012697 abnormal maternal body weight gain http://purl.obolibrary.org/obo/MP_0009661 abnormal pregnancy anomaly in the expected amount of female body weight gain during pregnancy http://purl.obolibrary.org/obo/MP_0012698 increased maternal body weight gain http://purl.obolibrary.org/obo/MP_0012697 abnormal maternal body weight gain greater than the expected amount of female body weight gain during pregnancy http://purl.obolibrary.org/obo/MP_0012699 decreased maternal body weight gain http://purl.obolibrary.org/obo/MP_0012697 abnormal maternal body weight gain reduction in the expected amount of female body weight gain during pregnancy http://purl.obolibrary.org/obo/MP_0012700 abnormal endocardial heart tube morphology http://purl.obolibrary.org/obo/MP_0000267 abnormal heart development any structural anomaly of the paired, longitudinal, endothelial-lined channels formed from the cardiogenic mesoderm in embryonic development; angiogenic cell clusters (aka angioblastic cords) located in a horse-shoe shape configuration in the cardiogenic plate coalesce to form the right and left endocardial heart tubes which then fuse in cephalo-caudal direction to form a single primitive heart tube http://purl.obolibrary.org/obo/MP_0012701 increased embryonic neuroepithelium apoptosis http://purl.obolibrary.org/obo/MP_0012505 increased neural tube apoptosis increase in the number of cells of the embryonic neuroepithelium undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0012702 increased embryonic neuroepithelium thickness http://purl.obolibrary.org/obo/MP_0004261 abnormal embryonic neuroepithelium morphology increased width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells http://purl.obolibrary.org/obo/MP_0012703 decreased embryonic neuroepithelium thickness http://purl.obolibrary.org/obo/MP_0004261 abnormal embryonic neuroepithelium morphology reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells http://purl.obolibrary.org/obo/MP_0012704 abnormal embryonic neuroepithelial cell proliferation http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology any anomaly in the ability of the cells of the embryonic neuroepithelium to undergo expansion by cell division http://purl.obolibrary.org/obo/MP_0012705 increased embryonic neuroepithelial cell proliferation http://purl.obolibrary.org/obo/MP_0012704 abnormal embryonic neuroepithelial cell proliferation increase in the expansion rate of the cells of the embryonic neuroepithelium by cell division http://purl.obolibrary.org/obo/MP_0012706 decreased embryonic neuroepithelial cell proliferation http://purl.obolibrary.org/obo/MP_0012704 abnormal embryonic neuroepithelial cell proliferation decrease in the expansion rate of the cells of the embryonic neuroepithelium by cell division http://purl.obolibrary.org/obo/MP_0012707 incomplete caudal neuropore closure http://purl.obolibrary.org/obo/MP_0012544 abnormal caudal neuropore morphology incomplete joining together of the neural folds of the caudal opening of the neural tube; failure of caudal neuropore closure results in spina bifida, the severity of which depends on how much of the spinal cord remains exposed http://purl.obolibrary.org/obo/MP_0012708 delayed rostral neuropore closure http://purl.obolibrary.org/obo/MP_0012543 abnormal rostral neuropore morphology a delay in the fusion of the cephalic neural folds http://purl.obolibrary.org/obo/MP_0012709 delayed caudal neuropore closure http://purl.obolibrary.org/obo/MP_0012544 abnormal caudal neuropore morphology a delay in the joining together of the neural folds of the caudal opening of the neural tube http://purl.obolibrary.org/obo/MP_0012710 diastematomyelia http://purl.obolibrary.org/obo/MP_0005297 spina bifida occulta a rare congenital anomaly that results in the splitting of the spinal cord in a longitudinal direction, usually at the level of the upper lumbar vertebra; this condition occurs in the presence of an osseous (bone), cartilaginous or fibrous septum in the central portion of the spinal canal which then produces a complete or incomplete sagittal division of the spinal cord into two hemicords, each half being surrounded by a dural sac; when the split does not reunite distally to the spur, the condition is referred to as a diplomyelia http://purl.obolibrary.org/obo/MP_0012711 diplomyelia http://purl.obolibrary.org/obo/MP_0000955 abnormal spinal cord morphology true duplication of the spinal cord; each cord has two dorsal and two ventral horns and paired nerve roots, but the two cords are contained within a single dural sac http://purl.obolibrary.org/obo/MP_0012712 spinal cord degeneration http://purl.obolibrary.org/obo/MP_0000955 abnormal spinal cord morphology a retrogressive impairment of function or destruction of the spinal cord http://purl.obolibrary.org/obo/MP_0012713 abnormal ventral ectodermal ridge morphology http://purl.obolibrary.org/obo/MP_0002861 abnormal tail bud morphology any structural anomaly of the morphologically distinct group of ectodermal cells that serves as an important signaling center in the mouse tail-bud following completion of gastrulation, and contains progenitor cells that contribute to the ventral midline ectoderm of the tail; ablation of the VER leads to defects in somitogenesis and tail elongation http://purl.obolibrary.org/obo/MP_0012714 decreased ventral ectodermal ridge size http://purl.obolibrary.org/obo/MP_0012713 abnormal ventral ectodermal ridge morphology reduced size of the morphologically distinct group of ectodermal cells that serves as an important signaling center in the mouse tail-bud following completion of gastrulation, and contains progenitor cells that contribute to the ventral midline ectoderm of the tail http://purl.obolibrary.org/obo/MP_0012715 abnormal hemangioblast morphology http://purl.obolibrary.org/obo/MP_0011247 abnormal yolk sac hematopoietic stem cell morphology any structural anomaly of the pluripotent precursor cell in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells; hemangioblasts are the progenitors that form the blood islands http://purl.obolibrary.org/obo/MP_0012716 abnormal hemangioblast number http://purl.obolibrary.org/obo/MP_0012715 abnormal hemangioblast morphology deviation from the normal numbers of pluripotent precursor cells in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells; hemangioblasts are the progenitors that form the blood islands http://purl.obolibrary.org/obo/MP_0012717 increased hemangioblast number http://purl.obolibrary.org/obo/MP_0012716 abnormal hemangioblast number increased number of the pluripotent precursor cells in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells; hemangioblasts are the progenitors that form the blood islands http://purl.obolibrary.org/obo/MP_0012718 decreased hemangioblast number http://purl.obolibrary.org/obo/MP_0012716 abnormal hemangioblast number reduced number of the pluripotent precursor cells in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells; hemangioblasts are the progenitors that form the blood islands http://purl.obolibrary.org/obo/MP_0012719 abnormal neck morphology http://purl.obolibrary.org/obo/MP_0005378 growth/size/body phenotype any structural anomaly of the part of body by which the head is connected to the trunk extending from the base of the cranium to the top of the shoulders http://purl.obolibrary.org/obo/MP_0012720 elongated neck http://purl.obolibrary.org/obo/MP_0012719 abnormal neck morphology increased length of the neck http://purl.obolibrary.org/obo/MP_0012721 short neck http://purl.obolibrary.org/obo/MP_0012719 abnormal neck morphology decreased length of the neck http://purl.obolibrary.org/obo/MP_0012722 absent neck http://purl.obolibrary.org/obo/MP_0012719 abnormal neck morphology absence of the part of body by which the head is connected to the trunk extending from the base of the cranium to the top of the shoulders http://purl.obolibrary.org/obo/MP_0012723 abnormal nuchal region morphology http://purl.obolibrary.org/obo/MP_0012719 abnormal neck morphology any structural anomaly of the posterior region of the neck, including the suboccipital region http://purl.obolibrary.org/obo/MP_0012724 failure of head fold formation http://purl.obolibrary.org/obo/MP_0011257 abnormal head fold morphology inability to form the crescent-shaped, ventrally located fold of the embryonic disc at the future cephalic end of the developing embryo; the head fold constitutes the first body fold, and initiates brain, foregut and heart development http://purl.obolibrary.org/obo/MP_0012725 small sebaceous gland http://purl.obolibrary.org/obo/MP_0000647 abnormal sebaceous gland morphology decreased size of the sebum secreting glands of the hair shaft http://purl.obolibrary.org/obo/MP_0012726 abnormal uterine spiral artery morphology http://purl.obolibrary.org/obo/MP_0004256 abnormal maternal decidual layer morphology any structural anomaly of the corkscrew-like arteries in premenstrual or progestational endometrium; uterine spiral arteries play a vital role in supplying nutrients to the placenta and fetus, and are thus remodeled into highly dilated inelastic vessels by the action of invading trophoblast (physiological change) http://purl.obolibrary.org/obo/MP_0012727 abnormal uterine spiral artery remodeling http://purl.obolibrary.org/obo/MP_0009670 abnormal uterine angiogenesis any anomaly of the physiological conversion of the uterine spiral arteries into highly dilated vessels by the action of invading trophoblast; in pregnancy, trophoblast invasion and uterine spiral artery remodeling are important for lowering maternal vascular resistance and increasing uteroplacental blood flow; this process involves loss of smooth muscle and elastic lamina from the vessel wall, and significant dilation at the mouth of the vessel; impaired spiral artery remodeling has been implicated in preeclampsia, fetal growth restriction, and preterm labor http://purl.obolibrary.org/obo/MP_0012728 abnormal somite border morphology http://purl.obolibrary.org/obo/MP_0001688 abnormal somite development any structural anomaly of the anatomical surface separating somites; somite formation requires the physical separation of somitic tissue from the initially continuous presomitic mesoderm (PSM), coalescence of cells in the forming somite, and the establishment of a stable border between the somite and the PSM; when a somite forms in the anterior end of the PSM, an intersomitic boundary (also called a fissure, gap, or cleft) emerges, and it is rapidly followed by a mesenchymal-to-epithelial transition of cells that face a forming gap http://purl.obolibrary.org/obo/MP_0012729 abnormal common carotid artery morphology http://purl.obolibrary.org/obo/MP_0004181 abnormal carotid artery morphology any structural anomaly of the left or right common carotid arteries which extend headward on each side of the anterior neck and deliver oxygenated nutrient filled blood from the heart to the head, neck and brain; the left originates in the arch of the aorta over the heart; the right originates in the brachiocephalic trunk, the largest branch from the arch of the aorta; each common carotid artery divides into an external and an internal carotid artery http://purl.obolibrary.org/obo/MP_0012730 abnormal internal carotid artery morphology http://purl.obolibrary.org/obo/MP_0004181 abnormal carotid artery morphology any structural anomaly of the terminal branch of the left or right common carotid artery which supplies oxygenated blood to the brain and eyes http://purl.obolibrary.org/obo/MP_0012731 abnormal external carotid artery morphology http://purl.obolibrary.org/obo/MP_0004181 abnormal carotid artery morphology any structural anomaly of the terminal branch of the left or right common carotid artery which supplies oxygenated blood to the throat, neck glands, tongue, face, mouth, ear, scalp and dura mater of the meninges http://purl.obolibrary.org/obo/MP_0012732 abnormal perineural vascular plexus morphology http://purl.obolibrary.org/obo/MP_0000259 abnormal vascular development any structural anomaly of the capillary bed that initially surrounds the relative avascular brain and spinal cord; the perineural vascular plexus (PNVP) is the precursor to the blood brain barrier formed by angioblasts which migrate away from somites and is recruited to surround the neural tube in response to VEGF; vascularization of the brain and spinal cord occurs via angiogenesis as sprouting vessels from the PNVP invade the neuroepithelium and grow inward toward the ventricular lumen http://purl.obolibrary.org/obo/MP_0012733 abnormal behavioral response to methamphetamine http://purl.obolibrary.org/obo/MP_0009748 abnormal behavioral response to addictive substance anomaly in the behavioral response induced by methamphetamine such as induced hyperactivity or stereotypic behavior http://purl.obolibrary.org/obo/MP_0012734 abnormal response to radiation http://purl.obolibrary.org/obo/MP_0005266 abnormal metabolism any anomaly in the physiological changes induced by ionizing radiation such as UV light, X-rays, or gamma rays http://purl.obolibrary.org/obo/MP_0012735 abnormal response to exercise http://purl.obolibrary.org/obo/MP_0005266 abnormal metabolism any anomaly in the physiological changes induced by controlled exercise http://purl.obolibrary.org/obo/MP_0012736 abnormal polar body morphology http://purl.obolibrary.org/obo/MP_0006361 abnormal female germ cell morphology any structural anomaly of one of the small cells that are produced during the development of an oocyte and ultimately degenerate; a polar body contains one of the nuclei derived from the first or second meiotic division but little or no cytoplasm http://purl.obolibrary.org/obo/MP_0012737 abnormal primary polar body morphology http://purl.obolibrary.org/obo/MP_0012736 abnormal polar body morphology any structural anomaly of the small cell formed by the first meiotic division of oocytes http://purl.obolibrary.org/obo/MP_0012738 abnormal secondary polar body morphology http://purl.obolibrary.org/obo/MP_0012736 abnormal polar body morphology any structural anomaly of the small cell formed by the second meiotic division of oocytes; in mammals, the second polar body may fail to form unless the ovum has been penetrated by a sperm cell http://purl.obolibrary.org/obo/MP_0012739 abnormal anterior primitive streak morphology http://purl.obolibrary.org/obo/MP_0002231 abnormal primitive streak morphology any structural anomaly of the anterior region of the vertebrate primitive streak which gives rise to the axial and paraxial mesoderm, the definitive endoderm, the primitive groove, and the primitive node http://purl.obolibrary.org/obo/MP_0012740 abnormal posterior primitive streak morphology http://purl.obolibrary.org/obo/MP_0002231 abnormal primitive streak morphology any structural anomaly of the posterior region of the vertebrate primitive streak which gives rise to the extraembryonic mesoderm http://purl.obolibrary.org/obo/MP_0012741 decreased neural crest cell proliferation http://purl.obolibrary.org/obo/MP_0009842 abnormal neural crest cell proliferation reduced ability of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult to undergo rapid expansion by cell division http://purl.obolibrary.org/obo/MP_0012742 increased neural crest cell proliferation http://purl.obolibrary.org/obo/MP_0009842 abnormal neural crest cell proliferation enhanced ability of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult to undergo rapid expansion by cell division http://purl.obolibrary.org/obo/MP_0012743 increased inner cell mass apoptosis http://purl.obolibrary.org/obo/MP_0010380 abnormal inner cell mass apoptosis increased number of cells of the blastocyst that develop into the body of the embryo undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0012744 increased neural crest cell apoptosis http://purl.obolibrary.org/obo/MP_0009844 abnormal neural crest cell apoptosis increased number of (any population) of neural crest cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0012746 abnormal neural crest cell delamination http://purl.obolibrary.org/obo/MP_0012745 abnormal neural crest cell physiology any anomaly in the process by which a neural crest cell (NCC) physically dissociates from the neuroepithelium in the dorsal aspect of the neural tube; premigratory NCCs exist within a fully polarized epithelial layer, adjoined by adherens junctions and tight junctions; NCC delamination involves an epithelial-mesenchymal transition (EMT) during which epithelial cells are converted into migratory mesenchymal cells; EMT requires loss of apical-basal cell polarity and dissolution of tight junctions and is accompanied by changes in cytoskeletal organization and a switch in adhesive properties so that cells can separate from the neuroepithelium and emigrate http://purl.obolibrary.org/obo/MP_0012747 abnormal cardiac neural crest cell morphology http://purl.obolibrary.org/obo/MP_0009845 abnormal neural crest cell morphology any structural anomaly of the cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs migrate to the circumpharyngeal ridge (an arc-shape ridge located dorsal to the forming caudal pharyngeal arches) and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT); cardiac NCCs contribute to the remodeling of arch arteries, septation of the cardiac OFT, closure of the ventricular septum, and innervation of the cardiac ganglia http://purl.obolibrary.org/obo/MP_0012748 increased cardiac neural crest cell number http://purl.obolibrary.org/obo/MP_0012747 abnormal cardiac neural crest cell morphology greater than expected number of cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs contribute to the remodeling of arch arteries, septation of the cardiac OFT, closure of the ventricular septum, and innervation of the cardiac ganglia http://purl.obolibrary.org/obo/MP_0012749 decreased cardiac neural crest cell number http://purl.obolibrary.org/obo/MP_0012747 abnormal cardiac neural crest cell morphology reduction in the number of cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs migrate to the circumpharyngeal ridge and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT), and contribute to the remodeling of arch arteries, septation of the cardiac OFT, closure of the ventricular septum, and innervation of the cardiac ganglia http://purl.obolibrary.org/obo/MP_0012750 absent cardiac neural crest cells http://purl.obolibrary.org/obo/MP_0012749 decreased cardiac neural crest cell number absence or loss of the cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs contribute to the remodeling of arch arteries, septation of the cardiac OFT, closure of the ventricular septum, and innervation of the cardiac ganglia; ablation of cardiac NCCs results in cardiac outflow defects http://purl.obolibrary.org/obo/MP_0012751 impaired cardiac neural crest cell differentiation http://purl.obolibrary.org/obo/MP_0012747 abnormal cardiac neural crest cell morphology abnormal or arrest of differentiation or patterning of the cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs have the potential to differentiate into smooth muscle cells of the cardiac outflow tract and its septum, walls of aortic and arch-derived arteries, all of the parasympathetic innervation of the heart, and the connective tissue of the glands in the head and neck region, including the thymus, thyroid and parathyroid glands http://purl.obolibrary.org/obo/MP_0012752 abnormal cardiac neural crest cell migration http://purl.obolibrary.org/obo/MP_0002950 abnormal neural crest cell migration any anomaly in the migratory path of cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs which originate from the lower hindbrain between the otic placode and third somite and migrate to the circumpharyngeal ridge (an arc-shape ridge located dorsal to the forming caudal pharyngeal arches) and then into the 3rd, 4th and 6th pharyngeal arches and the cardiac outflow tract (OFT); cardiac NCCs undergo migration away from the neural tube by following a dorsolateral path under the ectoderm, leading them to the pharyngeal arches; after pausing, they resume migration under the pharyngeal endoderm and, along the aortic arch arteries, populate the cardiac OFT where they contribute the aorticopulmonary septum, and ultimately colonize the heart to form the ventricular septum and cardiac ganglia http://purl.obolibrary.org/obo/MP_0012753 increased cardiac neural crest cell apoptosis http://purl.obolibrary.org/obo/MP_0012744 increased neural crest cell apoptosis increased number of cardiac neural crest cells (NCCs) undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0012754 abnormal cranial neural crest cell morphology http://purl.obolibrary.org/obo/MP_0009845 abnormal neural crest cell morphology any structural anomaly of the neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage http://purl.obolibrary.org/obo/MP_0012755 decreased cranial neural crest cell number http://purl.obolibrary.org/obo/MP_0012754 abnormal cranial neural crest cell morphology reduction in the number of neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordial; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage http://purl.obolibrary.org/obo/MP_0012756 impaired cranial neural crest cell differentiation http://purl.obolibrary.org/obo/MP_0012754 abnormal cranial neural crest cell morphology abnormal or arrest of differentiation or patterning of the cranial neural crest cells http://purl.obolibrary.org/obo/MP_0012757 abnormal cranial neural crest cell migration http://purl.obolibrary.org/obo/MP_0002950 abnormal neural crest cell migration any anomaly in the migratory path of the cranial neural crest cells (NCCs), which originate in the anterior part of the developing embryo and reside between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordial; like their counterparts in the trunk, cranial NCCs contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage http://purl.obolibrary.org/obo/MP_0012758 abnormal cranial neural crest cell proliferation http://purl.obolibrary.org/obo/MP_0009842 abnormal neural crest cell proliferation any anomaly in the ability of the cranial neural crest cells (NCCs) to undergo rapid expansion by cell division http://purl.obolibrary.org/obo/MP_0012759 increased cranial neural crest cell proliferation http://purl.obolibrary.org/obo/MP_0012758 abnormal cranial neural crest cell proliferation enhanced ability of the cranial neural crest cells (NCCs) to undergo rapid expansion by cell division http://purl.obolibrary.org/obo/MP_0012760 decreased cranial neural crest cell proliferation http://purl.obolibrary.org/obo/MP_0012758 abnormal cranial neural crest cell proliferation reduced ability of the cranial neural crest cells (NCCs) to undergo rapid expansion by cell division http://purl.obolibrary.org/obo/MP_0012761 increased cranial neural crest cell apoptosis http://purl.obolibrary.org/obo/MP_0012744 increased neural crest cell apoptosis increased number of cranial neural crest cells (NCCs) undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0012766 abnormal KLRG1-positive NK cell number http://purl.obolibrary.org/obo/MP_0008043 abnormal NK cell number deviation in the number of KLRG1 positive NK cells that represent a maturation subset of NK cells and is linked to NK cell proliferation http://purl.obolibrary.org/obo/MP_0012767 increased KLRG1-positive NK cell number http://purl.obolibrary.org/obo/MP_0012766 abnormal KLRG1-positive NK cell number increase in the number of KLRG1 positive NK cells that represent a maturation subset of NK cells and is linked to NK cell proliferation http://purl.obolibrary.org/obo/MP_0012768 decreased KLRG1-positive NK cell number http://purl.obolibrary.org/obo/MP_0012766 abnormal KLRG1-positive NK cell number decrease in the number of KLRG1 positive NK cells that represent a maturation subset of NK cells and is linked to NK cell proliferation http://purl.obolibrary.org/obo/MP_0012780 abnormal phospholipid transfer protein activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity altered ability of phospholipid transfer proteins to transfer phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL) http://purl.obolibrary.org/obo/MP_0012781 increased phospholipid transfer protein activity http://purl.obolibrary.org/obo/MP_0012780 abnormal phospholipid transfer protein activity greater ability of phospholipd transfer proteins to transfer phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL) http://purl.obolibrary.org/obo/MP_0012782 decreased phospholipid transfer protein activity http://purl.obolibrary.org/obo/MP_0012780 abnormal phospholipid transfer protein activity reduction in the ability of phospholipd transfer proteins to transfer phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL) http://purl.obolibrary.org/obo/MP_0012784 abnormal rhombomere 1 morphology http://purl.obolibrary.org/obo/MP_0000933 abnormal rhombomere morphology any structural anomaly of the first transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order with the first rhombomere arising next to the midbrain-hindbrain boundary, or isthmus http://purl.obolibrary.org/obo/MP_0012785 decreased rhombomere 1 size http://purl.obolibrary.org/obo/MP_0012784 abnormal rhombomere 1 morphology reduced size of the first transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order with the first rhombomere arising next to the midbrain-hindbrain boundary, or isthmus http://purl.obolibrary.org/obo/MP_0012786 increased rhombomere 1 size http://purl.obolibrary.org/obo/MP_0012784 abnormal rhombomere 1 morphology increased size of the first transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order with the first rhombomere arising next to the midbrain-hindbrain boundary, or isthmus http://purl.obolibrary.org/obo/MP_0012787 absent rhombomere 1 http://purl.obolibrary.org/obo/MP_0012784 abnormal rhombomere 1 morphology absence of the first transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order with the first rhombomere arising next to the midbrain-hindbrain boundary, or isthmus http://purl.obolibrary.org/obo/MP_0012788 abnormal rhombomere 2 morphology http://purl.obolibrary.org/obo/MP_0000933 abnormal rhombomere morphology any structural anomaly of the second transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012789 decreased rhombomere 2 size http://purl.obolibrary.org/obo/MP_0012788 abnormal rhombomere 2 morphology reduced size of the second transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012790 increased rhombomere 2 size http://purl.obolibrary.org/obo/MP_0012788 abnormal rhombomere 2 morphology increased size of the second transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012791 absent rhombomere 2 http://purl.obolibrary.org/obo/MP_0012788 abnormal rhombomere 2 morphology absence of the second transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012792 abnormal rhombomere 3 morphology http://purl.obolibrary.org/obo/MP_0000933 abnormal rhombomere morphology any structural anomaly of the third transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012793 decreased rhombomere 3 size http://purl.obolibrary.org/obo/MP_0012792 abnormal rhombomere 3 morphology reduced size of the third transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012794 increased rhombomere 3 size http://purl.obolibrary.org/obo/MP_0012792 abnormal rhombomere 3 morphology increased size of the third transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012795 absent rhombomere 3 http://purl.obolibrary.org/obo/MP_0012792 abnormal rhombomere 3 morphology absence of the third transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012796 abnormal rhombomere 4 morphology http://purl.obolibrary.org/obo/MP_0000933 abnormal rhombomere morphology any structural anomaly of the fourth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012797 decreased rhombomere 4 size http://purl.obolibrary.org/obo/MP_0012796 abnormal rhombomere 4 morphology reduced size of the fourth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012798 increased rhombomere 4 size http://purl.obolibrary.org/obo/MP_0012796 abnormal rhombomere 4 morphology increased size of the fourth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012799 absent rhombomere 4 http://purl.obolibrary.org/obo/MP_0012796 abnormal rhombomere 4 morphology absence of the fourth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012800 abnormal rhombomere 5 morphology http://purl.obolibrary.org/obo/MP_0000933 abnormal rhombomere morphology any structural anomaly of the fifth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012801 decreased rhombomere 5 size http://purl.obolibrary.org/obo/MP_0012800 abnormal rhombomere 5 morphology reduced size of the fifth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012802 increased rhombomere 5 size http://purl.obolibrary.org/obo/MP_0012800 abnormal rhombomere 5 morphology increased size of the fifth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012803 absent rhombomere 5 http://purl.obolibrary.org/obo/MP_0012800 abnormal rhombomere 5 morphology absence of the fifth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012804 abnormal rhombomere 6 morphology http://purl.obolibrary.org/obo/MP_0000933 abnormal rhombomere morphology any structural anomaly of the sixth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012805 decreased rhombomere 6 size http://purl.obolibrary.org/obo/MP_0012804 abnormal rhombomere 6 morphology reduced size of the sixth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012806 increased rhombomere 6 size http://purl.obolibrary.org/obo/MP_0012804 abnormal rhombomere 6 morphology increased size of the sixth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012807 absent rhombomere 6 http://purl.obolibrary.org/obo/MP_0012804 abnormal rhombomere 6 morphology absence of the sixth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012808 abnormal rhombomere 7 morphology http://purl.obolibrary.org/obo/MP_0000933 abnormal rhombomere morphology any structural anomaly of the seventh transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012809 decreased rhombomere 7 size http://purl.obolibrary.org/obo/MP_0012808 abnormal rhombomere 7 morphology reduced size of the seventh transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012810 increased rhombomere 7 size http://purl.obolibrary.org/obo/MP_0012808 abnormal rhombomere 7 morphology increased size of the seventh transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012811 absent rhombomere 7 http://purl.obolibrary.org/obo/MP_0012808 abnormal rhombomere 7 morphology absence of the seventh transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012812 abnormal rhombomere 8 morphology http://purl.obolibrary.org/obo/MP_0000933 abnormal rhombomere morphology any structural anomaly of the eighth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012813 decreased rhombomere 8 size http://purl.obolibrary.org/obo/MP_0012812 abnormal rhombomere 8 morphology reduced size of the eighth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012814 increased rhombomere 8 size http://purl.obolibrary.org/obo/MP_0012812 abnormal rhombomere 8 morphology increased size of the eighth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012815 absent rhombomere 8 http://purl.obolibrary.org/obo/MP_0012812 abnormal rhombomere 8 morphology absence of the eighth transiently divided segment of the developing rhombencephalon; rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates; rhombomeres are numbered in caudal to rostral order http://purl.obolibrary.org/obo/MP_0012816 abnormal rhombomere boundary morphology http://purl.obolibrary.org/obo/MP_0000933 abnormal rhombomere morphology any structural anomaly of the anatomical surface separating the rhombomere segments http://purl.obolibrary.org/obo/MP_0012817 rhombomere fusion http://purl.obolibrary.org/obo/MP_0000933 abnormal rhombomere morphology the union of one or more rhombomeres into a single structure http://purl.obolibrary.org/obo/MP_0012818 rhombomere transformation http://purl.obolibrary.org/obo/MP_0000933 abnormal rhombomere morphology homeotic transformation of a specific rhombomere to adopt the fate of another http://purl.obolibrary.org/obo/MP_0013000 absent cerebral aqueduct http://purl.obolibrary.org/obo/MP_0005537 abnormal cerebral aqueduct morphology absence of the channel in the mesencephalon that connects the third and fourth ventricles http://purl.obolibrary.org/obo/MP_0013001 abnormal enteric neural crest cell morphology http://purl.obolibrary.org/obo/MP_0009845 abnormal neural crest cell morphology any structural anomaly of the neural crest cells that arise predominantly from the vagal region of the neural tube (vagal neural crest), adjacent to somites 1-7 and migrate rostro-caudally along the gastrointestinal tract to form two ganglionated plexuses of neurons and glial cells that comprise the enteric nervous system (ENS); a smaller proportion of ENCCs come from the sacral neural crest, caudal to somite 28, and migrate caudo-rostrally to colonize the distal gut; neural crest cells are termed enteric neural crest-derived cells upon entering the foregut at E9-9.5 in mice (after 4 weeks gestation in humans) http://purl.obolibrary.org/obo/MP_0013002 decreased enteric neural crest cell number http://purl.obolibrary.org/obo/MP_0013001 abnormal enteric neural crest cell morphology a reduction in the number of neural crest cells that arise predominantly from the vagal region of the neural tube (vagal neural crest), adjacent to somites 1-7 and migrate rostro-caudally along the gastrointestinal tract to form two ganglionated plexuses of neurons and glial cells that comprise the enteric nervous system (ENS); a smaller proportion of ENCCs come from the sacral neural crest, caudal to somite 28, and migrate caudo-rostrally to colonize the distal gut http://purl.obolibrary.org/obo/MP_0013003 absent enteric neural crest cell http://purl.obolibrary.org/obo/MP_0013002 decreased enteric neural crest cell number absence or loss of the neural crest cells that arise predominantly from the vagal region of the neural tube (vagal neural crest), adjacent to somites 1-7 and migrate rostro-caudally along the gastrointestinal tract to form two ganglionated plexuses of neurons and glial cells that comprise the enteric nervous system (ENS); a smaller proportion of ENCCs come from the sacral neural crest, caudal to somite 28, and migrate caudo-rostrally to colonize the distal gut http://purl.obolibrary.org/obo/MP_0013004 abnormal enteric neural crest cell proliferation http://purl.obolibrary.org/obo/MP_0009842 abnormal neural crest cell proliferation any anomaly in the ability of the enteric neural crest cells to undergo rapid expansion by cell division http://purl.obolibrary.org/obo/MP_0013005 decreased enteric neural crest cell proliferation http://purl.obolibrary.org/obo/MP_0013004 abnormal enteric neural crest cell proliferation reduced ability of the enteric neural crest cells to undergo rapid expansion by cell division http://purl.obolibrary.org/obo/MP_0013006 abnormal enteric neural crest cell migration http://purl.obolibrary.org/obo/MP_0002950 abnormal neural crest cell migration any anomaly in the migratory path or behavior of the neural crest cells (NCCs) that arise predominantly from the vagal (neck) region of the neural tube (vagal neural crest), adjacent to somites 1-7, and migrate rostro-caudally along the gastrointestinal tract to form two ganglionated plexuses of neurons and glial cells that comprise the enteric nervous system (ENS); a smaller proportion of ENCCs come from the sacral neural crest, caudal to somite 28, and migrate caudo-rostrally to colonize the distal gut; NCCs are termed enteric neural crest-derived cells upon entering the foregut at E9-9.5 in mice (after 4 weeks gestation in humans) and the colonization process is complete by E15.5 (after 7 weeks gestation in humans) http://purl.obolibrary.org/obo/MP_0013007 abnormal vagal neural crest cell migration http://purl.obolibrary.org/obo/MP_0002950 abnormal neural crest cell migration any anomaly in the migratory path or behavior of the neural crest cells (NCCs) that arise from the vagal (neck) region of the neural tube (vagal neural crest), adjacent to somites 1-7; at approximately E8.5-9 in the mouse, vagal NCCs invade the anterior foregut and migrate in a rostral to caudal direction to colonize the entire foregut, midgut, cecum, and hindgut and give rise to the majority of the enteric nervous system (ENS); colonization is complete by E15.5 (or after 7 weeks gestation in humans); the most caudal vagal NCCs, emanating from a region overlapping with the most anterior trunk NCCs, make a small contribution to the ENS of the esophagus and the anterior stomach http://purl.obolibrary.org/obo/MP_0013008 abnormal sacral neural crest cell migration http://purl.obolibrary.org/obo/MP_0002950 abnormal neural crest cell migration any anomaly in the migratory path or behavior of the neural crest cells (NCCs) that arise from the sacral region of the neural tube (sacral neural crest), caudal to somite 28, and migrate caudo-rostrally to contribute to a small fraction of enteric neurons and glia in the distal midgut and hindgut; in the mouse, sacral NCCs emigrate from the neural tube at E9.5, accumulate bilateral to the hindgut to form prospective pelvic ganglia at E11.5, and from there enter the distal hindgut through its ventrolateral side at E13.5; they then migrate along nerve fibers extending from the pelvic ganglia toward the proximal hindgut, intermingling with rostrocaudally migrating vagal NCCs to differentiate into neurons and glia http://purl.obolibrary.org/obo/MP_0013009 increased vagal neural crest cell apoptosis http://purl.obolibrary.org/obo/MP_0012744 increased neural crest cell apoptosis increased number of vagal neural crest cells (NCCs) undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0013010 abnormal vagal neural crest cell morphology http://purl.obolibrary.org/obo/MP_0009845 abnormal neural crest cell morphology any structural anomaly of the neural crest cells (NCCs) that arise from the vagal (neck) region of the neural tube (vagal neural crest), adjacent to somites 1-7 (the cranial part of the vagal level overlaps the caudal part of the cranial level, as the first few somites form adjacent to the rhombencephalon, not the spinal cord); the vagal neural crest produces the neurons and glial cells of the enteric nervous system (ENS); like NCCs from other axial levels, the vagal neural crest contributes to the neurons and glial cells of the peripheral nervous system and the melanocytes that populate the skin http://purl.obolibrary.org/obo/MP_0013011 absent vagal neural crest cells http://purl.obolibrary.org/obo/MP_0013010 abnormal vagal neural crest cell morphology absence of the neural crest cells (NCCs) that arise from the vagal (neck) region of the neural tube (vagal neural crest), adjacent to somites 1-7 http://purl.obolibrary.org/obo/MP_0013012 abnormal trunk neural crest cell migration http://purl.obolibrary.org/obo/MP_0002950 abnormal neural crest cell migration any anomaly in the migratory path or behavior of the neural crest cells (NCCs) that arise from the trunk neural crest which lies between the vagal and sacral neural crest; there are two major pathways taken by the migrating trunk NCCs: (1) one group of cells fated to become melanocytes (the melanin-forming pigment cells) migrates dorsolaterally into the ectoderm towards the ventral midline and colonizes the skin and hair follicles; (2) a second group of cells migrates ventrolaterally through the anterior portion of each sclerotome; the cells that remain in the sclerotome form the dorsal root ganglia containing the sensory neurons, whereas those that continue more ventrally form the sympathetic ganglia, chromaffin cells of the adrenal medulla, Schwann (precursor) cells, and the nerve clusters surrounding the aorta http://purl.obolibrary.org/obo/MP_0013013 abnormal trunk neural crest cell morphology http://purl.obolibrary.org/obo/MP_0009845 abnormal neural crest cell morphology any structural anomaly of the neural crest cells (NCCs) that arise from the trunk neural crest (located between the vagal and sacral neural crest) and differentiate into a variety of cell types, including melanocytes, the neurons and glia of the dorsal root and sympathetic ganglia, Schwann (precursor) cells, chromaffin cells of the adrenal medulla, and the nerve clusters surrounding the aorta http://purl.obolibrary.org/obo/MP_0013014 increased trunk neural crest cell apoptosis http://purl.obolibrary.org/obo/MP_0012744 increased neural crest cell apoptosis increased number of trunk neural crest cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0013021 abnormal Ly6C high monocyte number http://purl.obolibrary.org/obo/MP_0012441 abnormal monocyte cell number deviation in the number of monocytes that express high levels of Ly6C and low MHC class II that represent a subset of circulating inflammatory monocytes that are recruited to infected or inflamed tissues http://purl.obolibrary.org/obo/MP_0013022 increased Ly6C high monocyte number http://purl.obolibrary.org/obo/MP_0013021 abnormal Ly6C high monocyte number increase in the number of monocytes that express high levels of Ly6C and low MHC class II that represent a subset of circulating inflammatory monocytes that are recruited to infected or inflamed tissues http://purl.obolibrary.org/obo/MP_0013023 decreased Ly6C high monocyte number http://purl.obolibrary.org/obo/MP_0013021 abnormal Ly6C high monocyte number decrease in the number of monocytes that express high levels of Ly6C and low MHC class II that represent a subset of circulating inflammatory monocytes that are recruited to infected or inflamed tissues http://purl.obolibrary.org/obo/MP_0013024 abnormal Ly6C low monocyte number http://purl.obolibrary.org/obo/MP_0012441 abnormal monocyte cell number deviation in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes http://purl.obolibrary.org/obo/MP_0013025 increased Ly6C low monocyte number http://purl.obolibrary.org/obo/MP_0013024 abnormal Ly6C low monocyte number increase in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes http://purl.obolibrary.org/obo/MP_0013026 decreased Ly6C low monocyte number http://purl.obolibrary.org/obo/MP_0013024 abnormal Ly6C low monocyte number decrease in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes http://purl.obolibrary.org/obo/MP_0013027 wounding http://purl.obolibrary.org/obo/MP_0005376 homeostasis/metabolism phenotype an injury resulting in damage that tears, cuts or breaks tissue http://purl.obolibrary.org/obo/MP_0013028 open abrasion http://purl.obolibrary.org/obo/MP_0013027 wounding damage to the skin consisting of loss of the epidermis and portions of the dermis but not the complete thickness of the skin http://purl.obolibrary.org/obo/MP_0013029 open avulsion http://purl.obolibrary.org/obo/MP_0013027 wounding a wound where the tissue has been torn from its attachment.; avulsion of skin on the extremities is sometimes called degloving http://purl.obolibrary.org/obo/MP_0013030 open incision http://purl.obolibrary.org/obo/MP_0013027 wounding a wound created by a sharp object; edges are smooth and trauma to surrounding tissue is minimal http://purl.obolibrary.org/obo/MP_0013031 open laceration http://purl.obolibrary.org/obo/MP_0013027 wounding an irregular wound created by tearing of tissue; damage to both superficial and underlying tissue is variable http://purl.obolibrary.org/obo/MP_0013032 open puncture http://purl.obolibrary.org/obo/MP_0013027 wounding a penetrating wound cause by pointed object (e.g. bites) http://purl.obolibrary.org/obo/MP_0013033 closed contusion http://purl.obolibrary.org/obo/MP_0013027 wounding damage of the skin and/or underlying strutures without breaking the skin (e.g. bruising, crush) http://purl.obolibrary.org/obo/MP_0013034 entire body wounds http://purl.obolibrary.org/obo/MP_0013027 wounding injuries resulting in damage that tears or breaks tissue occurring across the whole body http://purl.obolibrary.org/obo/MP_0013035 entire body open abrasion http://purl.obolibrary.org/obo/MP_0013034 entire body wounds damage to the skin consisting of loss of the epidermis and portions of the dermis but not the complete thickness of the skin, occurring across the whole body http://purl.obolibrary.org/obo/MP_0013036 entire body open avulsion http://purl.obolibrary.org/obo/MP_0013034 entire body wounds a wound or wounds where the tissue has been torn from its attachment, occurring across the whole body; avulsion of skin on the extremities is sometimes called degloving http://purl.obolibrary.org/obo/MP_0013037 entire body open incision http://purl.obolibrary.org/obo/MP_0013034 entire body wounds a wound or wounds created by a sharp object, occurring across the whole body; edges are smooth and trauma to surrounding tissue is minimal http://purl.obolibrary.org/obo/MP_0013038 entire body open laceration http://purl.obolibrary.org/obo/MP_0013034 entire body wounds an irregular wound or wounds created by tearing of tissue, occurring across the whole body; damage to both superficial and underlying tissue is variable http://purl.obolibrary.org/obo/MP_0013039 entire body open puncture http://purl.obolibrary.org/obo/MP_0013034 entire body wounds a penetrating wound or wounds occurring across the whole body caused by pointed object (e.g. bite) http://purl.obolibrary.org/obo/MP_0013040 entire body closed contusion http://purl.obolibrary.org/obo/MP_0013034 entire body wounds damage of the skin and/or underlying strutures occurring across the whole body without breaking the skin (e.g. bruising, crush) http://purl.obolibrary.org/obo/MP_0013041 thorax wound http://purl.obolibrary.org/obo/MP_0013027 wounding injuries resulting in damage that tears or breaks tissue occurring on the thorax http://purl.obolibrary.org/obo/MP_0013042 thorax open abrasion http://purl.obolibrary.org/obo/MP_0013041 thorax wound damage to the skin consisting of loss of the epidermis and portions of the dermis but not the complete thickness of the skin, occurring on the thorax http://purl.obolibrary.org/obo/MP_0013043 thorax open avulsion http://purl.obolibrary.org/obo/MP_0013041 thorax wound a wound on the thorax where the tissue has been torn from its attachment; avulsion of skin on the extremities is sometimes called degloving http://purl.obolibrary.org/obo/MP_0013044 thorax open incision http://purl.obolibrary.org/obo/MP_0013041 thorax wound a wound on the thorax created by a sharp object; edges are smooth and trauma to surrounding tissue is minimal http://purl.obolibrary.org/obo/MP_0013045 thorax open laceration http://purl.obolibrary.org/obo/MP_0013041 thorax wound an irregular wound on the thorax created by tearing of tissue; damage to both superficial and underlying tissue is variable http://purl.obolibrary.org/obo/MP_0013046 thorax open puncture http://purl.obolibrary.org/obo/MP_0013041 thorax wound a penetrating wound on the thorax cause by pointed object (e.g. bite) http://purl.obolibrary.org/obo/MP_0013047 thorax closed contusion http://purl.obolibrary.org/obo/MP_0013041 thorax wound damage of the skin and/or underlying strutures of the thorax without breaking the skin (e.g. bruising, crush) http://purl.obolibrary.org/obo/MP_0013048 abdomen wound http://purl.obolibrary.org/obo/MP_0013027 wounding injuries resulting in damage that tears or breaks tissue occurring on the abdomen http://purl.obolibrary.org/obo/MP_0013049 abdomen open abrasion http://purl.obolibrary.org/obo/MP_0013048 abdomen wound damage to the skin consisting of loss of the epidermis and portions of the dermis but not the complete thickness of the skin, occurring on the abdomen http://purl.obolibrary.org/obo/MP_0013050 abdomen open avulsion http://purl.obolibrary.org/obo/MP_0013048 abdomen wound a wound occurring on the abdomen where the tissue has been torn from its attachment http://purl.obolibrary.org/obo/MP_0013051 abdomen open incision http://purl.obolibrary.org/obo/MP_0013048 abdomen wound a wound occurring on the abdomen created by a sharp object; edges are smooth and trauma to surrounding tissue is minimal http://purl.obolibrary.org/obo/MP_0013052 abdomen open laceration http://purl.obolibrary.org/obo/MP_0013048 abdomen wound an irregular wound occurring on the abdomen created by tearing of tissue; damage to both superficial and underlying tissue is variable http://purl.obolibrary.org/obo/MP_0013053 abdomen open puncture http://purl.obolibrary.org/obo/MP_0013048 abdomen wound a penetrating wound occurring on the abdomen cause by pointed object (e.g. bite) http://purl.obolibrary.org/obo/MP_0013054 abdomen closed contusion http://purl.obolibrary.org/obo/MP_0013048 abdomen wound damage of the skin and/or underlying strutures without breaking the skin (e.g. bruising, crush), occurring on the abdomen http://purl.obolibrary.org/obo/MP_0013055 genital wound http://purl.obolibrary.org/obo/MP_0013027 wounding injuries resulting in damage that tears or breaks tissue occurring on genital tissue http://purl.obolibrary.org/obo/MP_0013056 genital open abrasion http://purl.obolibrary.org/obo/MP_0013055 genital wound damage to the skin consisting of loss of the epidermis and portions of the dermis but not the complete thickness of the skin occurring on genital tissue http://purl.obolibrary.org/obo/MP_0013057 genital open avulsion http://purl.obolibrary.org/obo/MP_0013055 genital wound a wound occurring on genital tissue where the tissue has been torn from its attachment http://purl.obolibrary.org/obo/MP_0013058 genital open incision http://purl.obolibrary.org/obo/MP_0013055 genital wound a wound occurring on genital tissue created by a sharp object; edges are smooth and trauma to surrounding tissue is minimal http://purl.obolibrary.org/obo/MP_0013059 genital open laceration http://purl.obolibrary.org/obo/MP_0013055 genital wound an irregular wound occurring on genital tissue created by tearing of tissue; damage to both superficial and underlying tissue is variable http://purl.obolibrary.org/obo/MP_0013060 genital open puncture http://purl.obolibrary.org/obo/MP_0013055 genital wound a penetrating wound occurring on genital tissue cause by pointed object (e.g. bite) http://purl.obolibrary.org/obo/MP_0013061 genital closed contusion http://purl.obolibrary.org/obo/MP_0013055 genital wound damage of the skin and/or underlying strutures without breaking the skin (e.g. bruising, crush) occurring on genital tissue http://purl.obolibrary.org/obo/MP_0013062 teat wound http://purl.obolibrary.org/obo/MP_0013027 wounding injuries resulting in damage that tears or breaks tissue occurring on teat tissue http://purl.obolibrary.org/obo/MP_0013063 teat open abrasion http://purl.obolibrary.org/obo/MP_0013062 teat wound damage to the skin consisting of loss of the epidermis and portions of the dermis but not the complete thickness of the skin occurring on teat tissue http://purl.obolibrary.org/obo/MP_0013064 teat open avulsion http://purl.obolibrary.org/obo/MP_0013062 teat wound a wound occurring on teat tissue where the tissue has been torn from its attachment http://purl.obolibrary.org/obo/MP_0013065 teat open incision http://purl.obolibrary.org/obo/MP_0013062 teat wound a wound occurring on teat tissue created by a sharp object; edges are smooth and trauma to surrounding tissue is minimal http://purl.obolibrary.org/obo/MP_0013066 teat open laceration http://purl.obolibrary.org/obo/MP_0013062 teat wound an irregular wound occurring on teat tissue created by tearing of tissue; damage to both superficial and underlying tissue is variable http://purl.obolibrary.org/obo/MP_0013067 teat open puncture http://purl.obolibrary.org/obo/MP_0013062 teat wound a penetrating wound occurring on teat tissue cause by pointed object (e.g. bite) http://purl.obolibrary.org/obo/MP_0013068 teat closed contusion http://purl.obolibrary.org/obo/MP_0013062 teat wound damage of the skin and/or underlying strutures occurring on teat tissue without breaking the skin (e.g. bruising, crush) http://purl.obolibrary.org/obo/MP_0013069 limb wound http://purl.obolibrary.org/obo/MP_0013027 wounding injuries resulting in damage that tears or breaks tissue occurring on limbs http://purl.obolibrary.org/obo/MP_0013070 limb open abrasion http://purl.obolibrary.org/obo/MP_0013069 limb wound damage to the skin occurring on limbs consisting of loss of the epidermis and portions of the dermis but not the complete thickness of the skin http://purl.obolibrary.org/obo/MP_0013071 limb open avulsion http://purl.obolibrary.org/obo/MP_0013069 limb wound a wound occurring on limbs where the tissue has been torn from its attachment; avulsion of skin on the extremities is sometimes called degloving http://purl.obolibrary.org/obo/MP_0013072 limb open incision http://purl.obolibrary.org/obo/MP_0013069 limb wound a wound occurring on limbs created by a sharp object; edges are smooth and trauma to surrounding tissue is minimal http://purl.obolibrary.org/obo/MP_0013073 limb open laceration http://purl.obolibrary.org/obo/MP_0013069 limb wound an irregular wound occurring on limbs created by tearing of tissue; damage to both superficial and underlying tissue is variable http://purl.obolibrary.org/obo/MP_0013074 limb open puncture http://purl.obolibrary.org/obo/MP_0013069 limb wound a penetrating wound occurring on limbs cause by pointed object (e.g. bite) http://purl.obolibrary.org/obo/MP_0013075 limb closed contusion http://purl.obolibrary.org/obo/MP_0013069 limb wound damage of the skin and/or underlying strutures occurring on limbs, without breaking the skin (e.g. bruising, crush) http://purl.obolibrary.org/obo/MP_0013076 autopod wound http://purl.obolibrary.org/obo/MP_0013027 wounding injuries resulting in damage that tears or breaks tissue occurring on autopods http://purl.obolibrary.org/obo/MP_0013077 autopod open abrasion http://purl.obolibrary.org/obo/MP_0013076 autopod wound damage to the skin occurring on autopods consisting of loss of the epidermis and portions of the dermis but not the complete thickness of the skin http://purl.obolibrary.org/obo/MP_0013078 autopod open avulsion http://purl.obolibrary.org/obo/MP_0013076 autopod wound a wound occurring on autopods where the tissue has been torn from its attachment; avulsion of skin on the extremities is sometimes called degloving http://purl.obolibrary.org/obo/MP_0013079 autopod open incision http://purl.obolibrary.org/obo/MP_0013076 autopod wound a wound occurring on autopods created by a sharp object; edges are smooth and trauma to surrounding tissue is minimal http://purl.obolibrary.org/obo/MP_0013080 autopod open laceration http://purl.obolibrary.org/obo/MP_0013076 autopod wound an irregular wound occurring on autopods created by tearing of tissue; damage to both superficial and underlying tissue is variable http://purl.obolibrary.org/obo/MP_0013081 autopod open puncture http://purl.obolibrary.org/obo/MP_0013076 autopod wound a penetrating wound occurring on autopods cause by pointed object (e.g. bite) http://purl.obolibrary.org/obo/MP_0013082 autopod closed contusion http://purl.obolibrary.org/obo/MP_0013076 autopod wound damage of the skin and/or underlying strutures occurring on autopods, without breaking the skin (e.g. bruising, crush) http://purl.obolibrary.org/obo/MP_0013083 tail wound http://purl.obolibrary.org/obo/MP_0013027 wounding injuries resulting in damage that tears or breaks tissue occurring on the tail http://purl.obolibrary.org/obo/MP_0013084 tail open abrasion http://purl.obolibrary.org/obo/MP_0013083 tail wound damage to the skin consisting of loss of the epidermis and portions of the dermis but not the complete thickness of the skin, occurring on the tail http://purl.obolibrary.org/obo/MP_0013085 tail open avulsion http://purl.obolibrary.org/obo/MP_0013083 tail wound a wound occurring on the tail where the tissue has been torn from its attachment; avulsion of skin on the extremities is sometimes called degloving http://purl.obolibrary.org/obo/MP_0013086 tail open incision http://purl.obolibrary.org/obo/MP_0013083 tail wound a wound occurring on the tail created by a sharp object; edges are smooth and trauma to surrounding tissue is minimal http://purl.obolibrary.org/obo/MP_0013087 tail open laceration http://purl.obolibrary.org/obo/MP_0013083 tail wound an irregular wound occurring on the tail created by tearing of tissue; damage to both superficial and underlying tissue is variable http://purl.obolibrary.org/obo/MP_0013088 tail open puncture http://purl.obolibrary.org/obo/MP_0013083 tail wound a penetrating wound occurring on the tail cause by pointed object (e.g. bite) http://purl.obolibrary.org/obo/MP_0013089 tail closed contusion http://purl.obolibrary.org/obo/MP_0013083 tail wound damage of the skin and/or underlying strutures without breaking the skin (e.g. bruising, crush), occurring on the tail http://purl.obolibrary.org/obo/MP_0013090 head or neck wound http://purl.obolibrary.org/obo/MP_0013027 wounding injuries resulting in damage that tears or breaks tissue occurring on the head and/or neck http://purl.obolibrary.org/obo/MP_0013091 head or neck open abrasion http://purl.obolibrary.org/obo/MP_0013090 head or neck wound damage to the skin consisting of loss of the epidermis and portions of the dermis but not the complete thickness of the skin, occurring on the head and/or neck http://purl.obolibrary.org/obo/MP_0013092 head or neck open avulsion http://purl.obolibrary.org/obo/MP_0013090 head or neck wound a wound where the tissue has been torn from its attachment occurring on the head and/or neck http://purl.obolibrary.org/obo/MP_0013093 head or neck open incision http://purl.obolibrary.org/obo/MP_0013090 head or neck wound a wound occurring on the head and/or neck created by a sharp object; edges are smooth and trauma to surrounding tissue is minimal http://purl.obolibrary.org/obo/MP_0013094 head or neck open laceration http://purl.obolibrary.org/obo/MP_0013090 head or neck wound an irregular wound occurring on the head and/or neck created by tearing of tissue; damage to both superficial and underlying tissue is variable http://purl.obolibrary.org/obo/MP_0013095 head or neck open puncture http://purl.obolibrary.org/obo/MP_0013090 head or neck wound a penetrating wound occurring on the head and/or neck cause by pointed object (e.g. bite) http://purl.obolibrary.org/obo/MP_0013096 head or neck closed contusion http://purl.obolibrary.org/obo/MP_0013090 head or neck wound damage of the skin and/or underlying strutures without breaking the skin (e.g. bruising, crush), occurring on the head and/or neck http://purl.obolibrary.org/obo/MP_0013097 ear wound http://purl.obolibrary.org/obo/MP_0013027 wounding injuries resulting in damage that tears or breaks tissue occurring on the ears http://purl.obolibrary.org/obo/MP_0013098 ear open abrasion http://purl.obolibrary.org/obo/MP_0013097 ear wound damage to the skin consisting of loss of the epidermis and portions of the dermis but not the complete thickness of the skin, occurring on the ears http://purl.obolibrary.org/obo/MP_0013099 ear open avulsion http://purl.obolibrary.org/obo/MP_0013097 ear wound a wound occurring on the ears where the tissue has been torn from its attachment http://purl.obolibrary.org/obo/MP_0013100 ear open incision http://purl.obolibrary.org/obo/MP_0013097 ear wound a wound occurring on the ears created by a sharp object; edges are smooth and trauma to surrounding tissue is minimal http://purl.obolibrary.org/obo/MP_0013101 ear open laceration http://purl.obolibrary.org/obo/MP_0013097 ear wound an irregular wound occurring on the ears created by tearing of tissue; damage to both superficial and underlying tissue is variable http://purl.obolibrary.org/obo/MP_0013102 ear open puncture http://purl.obolibrary.org/obo/MP_0013097 ear wound a penetrating wound occurring on the ears cause by pointed object (e.g. bite) http://purl.obolibrary.org/obo/MP_0013103 ear closed contusion http://purl.obolibrary.org/obo/MP_0013097 ear wound damage of the skin and/or underlying strutures without breaking the skin (e.g. bruising, crush), occurring on the ears http://purl.obolibrary.org/obo/MP_0013104 nose wound http://purl.obolibrary.org/obo/MP_0013027 wounding injuries resulting in damage that tears or breaks tissue occurring on the nose http://purl.obolibrary.org/obo/MP_0013105 nose open abrasion http://purl.obolibrary.org/obo/MP_0013104 nose wound damage to the skin consisting of loss of the epidermis and portions of the dermis but not the complete thickness of the skin, occurring on the nose http://purl.obolibrary.org/obo/MP_0013106 nose open avulsion http://purl.obolibrary.org/obo/MP_0013104 nose wound a wound occurring on the nose where the tissue has been torn from its attachment http://purl.obolibrary.org/obo/MP_0013107 nose open incision http://purl.obolibrary.org/obo/MP_0013104 nose wound a wound occurring on the nose created by a sharp object; edges are smooth and trauma to surrounding tissue is minimal http://purl.obolibrary.org/obo/MP_0013108 nose open laceration http://purl.obolibrary.org/obo/MP_0013104 nose wound an irregular wound occurring on the nose created by tearing of tissue; damage to both superficial and underlying tissue is variable http://purl.obolibrary.org/obo/MP_0013109 nose open puncture http://purl.obolibrary.org/obo/MP_0013104 nose wound a penetrating wound occurring on the nose cause by pointed object (e.g. bite) http://purl.obolibrary.org/obo/MP_0013110 nose closed contusion http://purl.obolibrary.org/obo/MP_0013104 nose wound damage of the skin and/or underlying strutures without breaking the skin (e.g. bruising, crush), occurring on the nose http://purl.obolibrary.org/obo/MP_0013111 greasy abdomen coat http://purl.obolibrary.org/obo/MP_0003849 greasy coat fur on the abdomen is oily in appearance or texture http://purl.obolibrary.org/obo/MP_0013112 greasy thorax coat http://purl.obolibrary.org/obo/MP_0003849 greasy coat fur on the thorax is oily in appearance or texture http://purl.obolibrary.org/obo/MP_0013113 greasy tail http://purl.obolibrary.org/obo/MP_0002111 abnormal tail morphology tail is oily in appearance or texture http://purl.obolibrary.org/obo/MP_0013114 greasy head/neck http://purl.obolibrary.org/obo/MP_0012719 abnormal neck morphology head and/or neck is oily in appearance or texture http://purl.obolibrary.org/obo/MP_0013115 focal hair loss in abdominal region http://purl.obolibrary.org/obo/MP_0000418 focal hair loss focal absence of hair on the abdomen, in those areas where hair is normally expected, resulting in visible patches of skin and uneven spots of hair growth on the body http://purl.obolibrary.org/obo/MP_0013116 focal hair loss in head/neck region http://purl.obolibrary.org/obo/MP_0000418 focal hair loss focal absence of hair in the head and/or neck region, in those areas where hair is normally expected, resulting in visible patches of skin and uneven spots of hair growth on the body http://purl.obolibrary.org/obo/MP_0013117 focal hair loss in thorax region http://purl.obolibrary.org/obo/MP_0000418 focal hair loss focal absence of hair on the thorax, in those areas where hair is normally expected, resulting in visible patches of skin and uneven spots of hair growth on the body http://purl.obolibrary.org/obo/MP_0013118 swellings http://purl.obolibrary.org/obo/MP_0010678 abnormal skin adnexa morphology appearance of abnormal enlargements of all descriptions (hard, soft, different shapes etc) under the skin http://purl.obolibrary.org/obo/MP_0013119 abdomen swellings http://purl.obolibrary.org/obo/MP_0013118 swellings appearance of abnormal enlargements of all descriptions (hard, soft, different shapes etc) under the skin in the abdominal region http://purl.obolibrary.org/obo/MP_0013120 urogenital swellings http://purl.obolibrary.org/obo/MP_0013118 swellings appearance of abnormal enlargements of all descriptions (hard, soft, different shapes etc) under the skin in the urogenital region http://purl.obolibrary.org/obo/MP_0013121 testicular swellings http://purl.obolibrary.org/obo/MP_0013118 swellings appearance of abnormal enlargements of all descriptions (hard, soft, different shapes etc) under the skin of the testicles http://purl.obolibrary.org/obo/MP_0013122 tail swellings http://purl.obolibrary.org/obo/MP_0013118 swellings appearance of abnormal enlargements of all descriptions (hard, soft, different shapes etc) under the skin of the tail http://purl.obolibrary.org/obo/MP_0013123 head/neck swellings http://purl.obolibrary.org/obo/MP_0013118 swellings appearance of abnormal enlargements of all descriptions (hard, soft, different shapes etc) under the skin in the head/neck region http://purl.obolibrary.org/obo/MP_0013124 mouth swellings http://purl.obolibrary.org/obo/MP_0013118 swellings appearance of abnormal enlargements of all descriptions (hard, soft, different shapes etc) in the mouth region http://purl.obolibrary.org/obo/MP_0013125 thorax swellings http://purl.obolibrary.org/obo/MP_0013118 swellings appearance of abnormal enlargements of all descriptions (hard, soft, different shapes etc) under the skin in the thorax region http://purl.obolibrary.org/obo/MP_0013126 teat swellings http://purl.obolibrary.org/obo/MP_0013118 swellings appearance of abnormal enlargements of all descriptions (hard, soft, different shapes etc) under the skin in the teat region http://purl.obolibrary.org/obo/MP_0013127 epistaxis http://purl.obolibrary.org/obo/MP_0002233 abnormal nose morphology hemorrhage from the nose, usually apparent when the blood drains out through the nostrils http://purl.obolibrary.org/obo/MP_0013128 nipple hemorrhage http://purl.obolibrary.org/obo/MP_0006078 abnormal nipple morphology bleeding from the nipples http://purl.obolibrary.org/obo/MP_0013130 abnormal gum color http://purl.obolibrary.org/obo/MP_0000452 abnormal mouth morphology anomaly in the color and shading of the gums, which normally present in shades of red http://purl.obolibrary.org/obo/MP_0013131 pale lips http://purl.obolibrary.org/obo/MP_0003769 abnormal lip morphology lips lack normal reddish coloration; often occurs with a bloodless or reduced vasculature condition http://purl.obolibrary.org/obo/MP_0013132 pale gums http://purl.obolibrary.org/obo/MP_0013130 abnormal gum color gums lack normal reddish coloration; often occurs with a bloodless or reduced vasculature condition http://purl.obolibrary.org/obo/MP_0013133 pale limbs http://purl.obolibrary.org/obo/MP_0002109 abnormal limb morphology limbs lack normal ruddy coloration; often occurs with a bloodless or reduced vasculature condition http://purl.obolibrary.org/obo/MP_0013134 poor circulation in autopods http://purl.obolibrary.org/obo/MP_0001633 poor circulation insufficient movement of blood throughout the autopods, resulting in a pale appearance and cool to touch http://purl.obolibrary.org/obo/MP_0013135 poor circulation in tail http://purl.obolibrary.org/obo/MP_0001633 poor circulation insufficient movement of blood throughout the tail, resulting in a pale appearance and cool to touch http://purl.obolibrary.org/obo/MP_0013136 genital discharge http://purl.obolibrary.org/obo/MP_0001919 abnormal reproductive system physiology the emission or secretion of unusual fluid from the genitals http://purl.obolibrary.org/obo/MP_0013137 nipple discharge http://purl.obolibrary.org/obo/MP_0006078 abnormal nipple morphology the emission or secretion of unusual fluid from the nipples http://purl.obolibrary.org/obo/MP_0013138 thin body http://purl.obolibrary.org/obo/MP_0001265 decreased body size lean or slender in form http://purl.obolibrary.org/obo/MP_0013139 moribund http://purl.obolibrary.org/obo/MP_0010769 abnormal survival in terminal decline and approaching death; lacking vitality or vigor and becoming unresponsive http://purl.obolibrary.org/obo/MP_0013140 excessive vocalization http://purl.obolibrary.org/obo/MP_0001529 abnormal vocalization producing sound from the vocal organs more frequently or more loudly than expected http://purl.obolibrary.org/obo/MP_0013141 sexually aggressive behaviour http://purl.obolibrary.org/obo/MP_0002566 abnormal sexual interaction subjects exhibit greater than the normal level of domineering, assertive posturing and/or hostile physical action toward partners while mating http://purl.obolibrary.org/obo/MP_0013142 anal soreness http://purl.obolibrary.org/obo/MP_0005034 abnormal anus morphology tenderness or irritation of the anal area, usually evident by redness of the area http://purl.obolibrary.org/obo/MP_0013143 penis inflammation http://purl.obolibrary.org/obo/MP_0003698 abnormal male reproductive system physiology local accumulation of fluid, plasma proteins, and leukocytes in the penis http://purl.obolibrary.org/obo/MP_0013144 greasy skin http://purl.obolibrary.org/obo/MP_0009931 abnormal skin appearance skin is oily in appearance or texture http://purl.obolibrary.org/obo/MP_0013145 eye discharge http://purl.obolibrary.org/obo/MP_0005253 abnormal eye physiology the emission or secretion of unusual fluid from the eyes http://purl.obolibrary.org/obo/MP_0013146 eye lesions http://purl.obolibrary.org/obo/MP_0002092 abnormal eye morphology lesions on or around the eyes http://purl.obolibrary.org/obo/MP_0013147 limb paralysis http://purl.obolibrary.org/obo/MP_0000753 paralysis loss of power of voluntary movement in muscles of the limbs through injury or disease of muscles or of the nerve supply http://purl.obolibrary.org/obo/MP_0013148 mastitis http://purl.obolibrary.org/obo/MP_0001881 abnormal mammary gland physiology inflammation of the teats or mammary glands http://purl.obolibrary.org/obo/MP_0013149 macrodactyly http://purl.obolibrary.org/obo/MP_0002110 abnormal digit morphology significant increase in the length and girth dimensions of most or all of a digit compared to the expected size http://purl.obolibrary.org/obo/MP_0013150 head/neck piloerection http://purl.obolibrary.org/obo/MP_0001492 abnormal pilomotor reflex anomaly in the involuntary bristling of hairs on the head and/or neck that occurs when an organism is cold or experiences strong emotions such as fear or awe http://purl.obolibrary.org/obo/MP_0013153 abnormal KLRG1+ CD8 alpha beta T cell number http://purl.obolibrary.org/obo/MP_0008077 abnormal CD8-positive, alpha-beta T cell number anomaly in the number of CD8+ alpha beta T cells that express KLRG1, a marker of effector and memory T cells http://purl.obolibrary.org/obo/MP_0013154 increased KLRG1+ CD8 alpha beta T cell number http://purl.obolibrary.org/obo/MP_0013153 abnormal KLRG1+ CD8 alpha beta T cell number increase in the number of CD8+ alpha beta T cells that express KLRG1, a marker of effector and memory T cells http://purl.obolibrary.org/obo/MP_0013155 decreased KLRG1+ CD8 alpha beta T cell number http://purl.obolibrary.org/obo/MP_0013153 abnormal KLRG1+ CD8 alpha beta T cell number decrease in the number of CD8+ alpha beta T cells that express KLRG1, a marker of effector and memory T cells http://purl.obolibrary.org/obo/MP_0013156 abnormal KLRG1+ CD4 alpha beta T cell number http://purl.obolibrary.org/obo/MP_0008073 abnormal CD4-positive, alpha beta T cell number anomaly in the number of CD4+ alpha beta T cells that express KLRG1, a marker of effector/memory and regulatory T cells http://purl.obolibrary.org/obo/MP_0013157 increased KLRG1+ CD4 alpha beta T cell number http://purl.obolibrary.org/obo/MP_0013156 abnormal KLRG1+ CD4 alpha beta T cell number increase in the number of CD4+ alpha beta T cells that express KLRG1, a marker of effector/memory and regulatory T cells http://purl.obolibrary.org/obo/MP_0013158 decreased KLRG1+ CD4 alpha beta T cell number http://purl.obolibrary.org/obo/MP_0013156 abnormal KLRG1+ CD4 alpha beta T cell number reduction in the number of CD4+ alpha beta T cells that express KLRG1, a marker of effector/memory and regulatory T cells http://purl.obolibrary.org/obo/MP_0013159 Purkinje cell axonal dystrophy http://purl.obolibrary.org/obo/MP_0003225 axonal dystrophy Purkinje cell-autonomous progressive dystrophy leading to cell death, manifested by axonal swellings and degeneration of nerve terminals, while Purkinje cell dendrites remain largely unaffected http://purl.obolibrary.org/obo/MP_0013160 impaired muscle regeneration http://purl.obolibrary.org/obo/MP_0000750 abnormal muscle regeneration inability, defects in ability or delayed ability to repair muscle after injury or disease http://purl.obolibrary.org/obo/MP_0013161 improved muscle regeneration http://purl.obolibrary.org/obo/MP_0000750 abnormal muscle regeneration faster or more complete repair to muscle after injury or disease http://purl.obolibrary.org/obo/MP_0013162 abnormal thyroid gland isthmus morphology http://purl.obolibrary.org/obo/MP_0000681 abnormal thyroid gland morphology any structural anomaly of the narrow median bridge that joins together the lower thirds of the two lateral (right and left) lobes of the thyroid gland and usually covers the second and the third tracheal rings; the thyroid isthmus is variable in presence and size, can change shape and size, and can encompass a cranially extending pyramid lobe (lobus pyramidalis or processus pyramidalis), remnant of the thyroglossal duct http://purl.obolibrary.org/obo/MP_0013163 absent thyroid gland isthmus http://purl.obolibrary.org/obo/MP_0013162 abnormal thyroid gland isthmus morphology absence of the narrow median bridge that joins together the lower thirds of the two lateral (right and left) lobes of the thyroid gland http://purl.obolibrary.org/obo/MP_0013164 abnormal forelimb bud morphology http://purl.obolibrary.org/obo/MP_0005650 abnormal limb bud morphology any structural anomaly of the limb bud that develops into a forelimb (usually the arm or front limb in mammalian species) http://purl.obolibrary.org/obo/MP_0013165 absent forelimb buds http://purl.obolibrary.org/obo/MP_0013164 abnormal forelimb bud morphology absence or loss of the limb bud that normally develops into a forelimb (usually the arm or front limb in mammalian species) http://purl.obolibrary.org/obo/MP_0013166 small forelimb buds http://purl.obolibrary.org/obo/MP_0013164 abnormal forelimb bud morphology reduced size of the limb bud that normally develops into a forelimb (usually the arm or front limb in mammalian species) http://purl.obolibrary.org/obo/MP_0013167 abnormal hindlimb bud morphology http://purl.obolibrary.org/obo/MP_0005650 abnormal limb bud morphology any structural anomaly of the limb bud that develops into a hindlimb (usually the leg or back limb in mammalian species) http://purl.obolibrary.org/obo/MP_0013168 absent hindlimb buds http://purl.obolibrary.org/obo/MP_0013167 abnormal hindlimb bud morphology absence or loss of the limb bud that normally develops into a hindlimb (usually the leg or back limb in mammalian species) http://purl.obolibrary.org/obo/MP_0013169 small hindlimb buds http://purl.obolibrary.org/obo/MP_0013167 abnormal hindlimb bud morphology reduced size of the limb bud that normally develops into a hindlimb (usually the leg or back limb in mammalian species) http://purl.obolibrary.org/obo/MP_0013170 eye swellings http://purl.obolibrary.org/obo/MP_0013118 swellings appearance of abnormal enlargements of all descriptions (hard, soft, different shapes etc) on or around the eyes http://purl.obolibrary.org/obo/MP_0013171 ear hemorrhage http://purl.obolibrary.org/obo/MP_0003878 abnormal ear physiology bleeding through the ear canal http://purl.obolibrary.org/obo/MP_0013172 miscarriage http://purl.obolibrary.org/obo/MP_0003699 abnormal female reproductive system physiology accidental or natural termination of a clear pregnancy at a stage where the fetus is incapable of surviving independently of the mother http://purl.obolibrary.org/obo/MP_0013173 trigeminal ganglion degeneration http://purl.obolibrary.org/obo/MP_0001092 abnormal trigeminal ganglion morphology retrogressive pathological change of the group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve) http://purl.obolibrary.org/obo/MP_0013174 pharynx stenosis http://purl.obolibrary.org/obo/MP_0002234 abnormal pharynx morphology abnormal narrowing or constriction of the passage between the mouth and the posterior nares and the larynx and esophagus http://purl.obolibrary.org/obo/MP_0013175 bifurcated tail http://purl.obolibrary.org/obo/MP_0002111 abnormal tail morphology the appearance of an abnormal division in the flexible elongated appendage located at the caudal end of the torso in many species http://purl.obolibrary.org/obo/MP_0013176 abnormal tail position or orientation http://purl.obolibrary.org/obo/MP_0002111 abnormal tail morphology tail is displaced from the normal location and/or does not orient in a typical pattern http://purl.obolibrary.org/obo/MP_0013178 tail necrosis http://purl.obolibrary.org/obo/MP_0002111 abnormal tail morphology morphological changes resulting from pathological death of tail tissue; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0013179 wavy tail http://purl.obolibrary.org/obo/MP_0002111 abnormal tail morphology undulations or a sinusoidal shape of the tail http://purl.obolibrary.org/obo/MP_0013180 truncated tail bud http://purl.obolibrary.org/obo/MP_0002861 abnormal tail bud morphology shortened tail bud that terminates in a blunt end (instead of a tapered end) http://purl.obolibrary.org/obo/MP_0013181 absent placenta http://purl.obolibrary.org/obo/MP_0001711 abnormal placenta morphology absence of the organ of metabolic interchange between fetus and mother, which is partly of embryonic origin and partly of maternal origin http://purl.obolibrary.org/obo/MP_0013182 increased spinal cord apoptosis http://purl.obolibrary.org/obo/MP_0003633 abnormal nervous system physiology increase in the number of cells of the neural tube undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0013183 absent trigeminal ganglion http://purl.obolibrary.org/obo/MP_0001092 abnormal trigeminal ganglion morphology absence of the group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve) http://purl.obolibrary.org/obo/MP_0013184 hemorrhagic ascites http://purl.obolibrary.org/obo/MP_0005324 ascites the presence of bloody or blood-stained serous fluid, frequently resulting from metastatic carcinoma, in the peritoneal cavity http://purl.obolibrary.org/obo/MP_0013185 absent anterior definitive endoderm http://purl.obolibrary.org/obo/MP_0008926 abnormal anterior definitive endoderm morphology absence of the mesendoderm which first migrates from the node and which gives rise to the gut http://purl.obolibrary.org/obo/MP_0013186 abnormal basilar artery morphology http://purl.obolibrary.org/obo/MP_0004950 abnormal brain vasculature morphology any structural anomaly of the unpaired artery that is formed by the union of the two vertebral arteries, runs forward within the skull just under the pons, divides into the two posterior cerebral arteries, and supplies the pons, cerebellum, posterior part of the cerebrum, and the inner ear http://purl.obolibrary.org/obo/MP_0013187 dilated basilar artery http://purl.obolibrary.org/obo/MP_0013186 abnormal basilar artery morphology stretched or widened aperture of the luminal space of the unpaired artery that is formed by the union of the two vertebral arteries, runs forward within the skull just under the pons, divides into the two posterior cerebral arteries, and supplies the pons, cerebellum, posterior part of the cerebrum, and the inner ear http://purl.obolibrary.org/obo/MP_0013190 abnormal sebaceous gland number http://purl.obolibrary.org/obo/MP_0000647 abnormal sebaceous gland morphology any anomaly in the number of the holocrine glands that secrete sebum into the hair follicles, or in hairless areas into ducts http://purl.obolibrary.org/obo/MP_0013191 increased sebaceous gland number http://purl.obolibrary.org/obo/MP_0013190 abnormal sebaceous gland number greater than normal numbers of the holocrine glands that secrete sebum into the hair follicles, or in hairless areas into ducts http://purl.obolibrary.org/obo/MP_0013192 decreased sebaceous gland number http://purl.obolibrary.org/obo/MP_0013190 abnormal sebaceous gland number fewer than normal numbers of the holocrine glands that secrete sebum into the hair follicles, or in hairless areas into ducts http://purl.obolibrary.org/obo/MP_0013193 sebaceous gland hypoplasia http://purl.obolibrary.org/obo/MP_0000647 abnormal sebaceous gland morphology underdevelopment and decreased size of the sebum secreting glands of the hair shaft, usually due to a decrease in the number of cells http://purl.obolibrary.org/obo/MP_0013194 absent anterior primitive streak http://purl.obolibrary.org/obo/MP_0012739 abnormal anterior primitive streak morphology absence of the anterior region of the vertebrate primitive streak which normally gives rise to the axial and paraxial mesoderm, the definitive endoderm, the primitive groove, and the primitive node http://purl.obolibrary.org/obo/MP_0013195 abnormal anterior primitive streak formation http://purl.obolibrary.org/obo/MP_0012739 abnormal anterior primitive streak morphology anomaly in the establishment of the anterior region of the vertebrate primitive streak which normally gives rise to the axial and paraxial mesoderm, the definitive endoderm, the primitive groove, and the primitive node http://purl.obolibrary.org/obo/MP_0013196 abnormal posterior primitive streak formation http://purl.obolibrary.org/obo/MP_0012740 abnormal posterior primitive streak morphology anomaly in the establishment of the posterior region of the vertebrate primitive streak which gives rise to the extraembryonic mesoderm http://purl.obolibrary.org/obo/MP_0013197 decreased embryonic cilium number http://purl.obolibrary.org/obo/MP_0004131 abnormal motile primary cilium morphology reduced number of the cilia of the mouse embryo found on the cells of the embryonic node http://purl.obolibrary.org/obo/MP_0013198 absent head mesenchyme http://purl.obolibrary.org/obo/MP_0011260 abnormal head mesenchyme morphology absence of the primordial embryonic connective tissue of the developing head, normally consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells http://purl.obolibrary.org/obo/MP_0013199 increased head mesenchyme apoptosis http://purl.obolibrary.org/obo/MP_0011260 abnormal head mesenchyme morphology increase in the number of cells of the head mesenchyme undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0013200 head mesenchyme hypoplasia http://purl.obolibrary.org/obo/MP_0011260 abnormal head mesenchyme morphology underdevelopment or reduced size of the head mesenchyme, usually due to a reduced cell number http://purl.obolibrary.org/obo/MP_0013201 head mesenchyme hyperplasia http://purl.obolibrary.org/obo/MP_0011260 abnormal head mesenchyme morphology overdevelopment or increased size of the head mesenchyme, usually due to an increased cell number http://purl.obolibrary.org/obo/MP_0013202 abnormal cilium morphology http://purl.obolibrary.org/obo/MP_0000358 abnormal cell morphology any structural anomaly of the specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface; each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole http://purl.obolibrary.org/obo/MP_0013207 absent endoderm http://purl.obolibrary.org/obo/MP_0001685 abnormal endoderm development absence of the innermost of the three primary germ layers of the embryo (the others being mesoderm and ectoderm) that is formed during gastrulation http://purl.obolibrary.org/obo/MP_0013208 abnormal cilium physiology http://purl.obolibrary.org/obo/MP_0005621 abnormal cell physiology any functional anomaly of the specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface; each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole http://purl.obolibrary.org/obo/MP_0013211 abnormal nonmotile primary cilium physiology http://purl.obolibrary.org/obo/MP_0013210 abnormal primary cilium physiology any functional anomaly of a primary cilium which contains a variable array of axonemal microtubules but does not contain molecular motors; nonmotile primary cilia are found on many different cell types and function as sensory organelles that concentrate and organize sensory signaling molecules http://purl.obolibrary.org/obo/MP_0013213 abnormal embryonic neuroepithelium primary cilium morphology http://purl.obolibrary.org/obo/MP_0013205 abnormal nonmotile primary cilium morphology any structural anomaly of the primary non-motile microtubule-based structures of the embryonic neuroepithelium which are typically short and straight, project apically into the neural tube lumen, and play an essential role in Sonic hedgehog (Shh) signalling and neural tube patterning http://purl.obolibrary.org/obo/MP_0013214 decreased embryonic neuroepithelium primary cilium number http://purl.obolibrary.org/obo/MP_0013213 abnormal embryonic neuroepithelium primary cilium morphology reduced number of the primary non-motile microtubule-based structures of the embryonic neuroepithelium which are typically short and straight, project apically into the neural tube lumen, and play an essential role in Sonic hedgehog (Shh) signalling and neural tube patterning http://purl.obolibrary.org/obo/MP_0013215 abnormal haptoglobin level http://purl.obolibrary.org/obo/MP_0008469 abnormal protein level anomaly in the amount of any of haptoglobin, a protein that binds free hemoglobin (Hb) released from erythrocytes with high affinity and thereby inhibits its oxidative activity http://purl.obolibrary.org/obo/MP_0013216 absent ectoderm http://purl.obolibrary.org/obo/MP_0001675 abnormal ectoderm development absence of the outer of the three primary germ layers of the embryo (the others being mesoderm and endoderm) that originates in the epiblast and is formed during gastrulation http://purl.obolibrary.org/obo/MP_0013217 abnormal posterior definitive endoderm morphology http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology any structural anomaly of the posterior region of the definitive endoderm which evolves into the midgut and hindgut, which will eventually differentiate into the large and small intestine http://purl.obolibrary.org/obo/MP_0013218 abnormal substantia nigra pars reticulata morphology http://purl.obolibrary.org/obo/MP_0000836 abnormal substantia nigra morphology any structural anomaly of the anterior (ventral) part of grey matter of the substantia nigra which contains smaller and loosely packed cells than the pars compacta, only some of which contain a small amount of pigment; the cells of pars reticulata bear a strong structural and functional resemblance to the inner segment of the globus pallidus; many cells in this region use GABA as a neurotransmitter http://purl.obolibrary.org/obo/MP_0013219 abnormal substantia nigra pars compacta morphology http://purl.obolibrary.org/obo/MP_0000836 abnormal substantia nigra morphology any structural anomaly of the posterior (dorsal) part of grey matter of the substantia nigra which contains large, polygonal, and densely packed dopamine-producing cells; pars compacta neurons are pigmented in many species http://purl.obolibrary.org/obo/MP_0013220 increased pancreas apoptosis http://purl.obolibrary.org/obo/MP_0006042 increased apoptosis increase in the number of cells of the pancreas undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0013221 pancreatic acinar-to-ductal metaplasia http://purl.obolibrary.org/obo/MP_0001944 abnormal pancreas morphology a reprogramming event that induces transdifferentiation of pancreatic acinar cells to a duct-like phenotype in response to inflammatory injury; ADM is associated with an increased risk of exocrine pancreatic cancer and is considered a precursor of pancreatic ductal adenocarcinoma http://purl.obolibrary.org/obo/MP_0013222 abnormal first pharyngeal pouch morphology http://purl.obolibrary.org/obo/MP_0006031 abnormal pharyngeal pouch morphology any structural anomaly of the first endodermal branchial pouch located between the first and second branchial arches; in mammals, the first pouch elongates to form a diverticulum known as the tubotympanic recess; the distal portion of this recess expands to reach the first branchial groove and form the middle ear cavity (aka tympanic cavity) and mastoid antrum; its proximal part remains tubular and forms the auditory tube (aka Eustachian or pharyngotympanic tube), which forms a communication between the nasopharynx and tympanic cavity http://purl.obolibrary.org/obo/MP_0013223 abnormal second pharyngeal pouch morphology http://purl.obolibrary.org/obo/MP_0006031 abnormal pharyngeal pouch morphology any structural anomaly of the second branchial pouch located between the second and third branchial arches; the dorsal elongation of the second pouch endoderm of all mammals, with the exception of rodents, gives rise to the epithelial lining of palatine tonsils; in rodents, the ventral portion of the second pouch appears to degenerate whereas the remaining part is incorporated into the lateral border of the pharynx; it appears that rodents no longer require tonsils as their function is carried out by the NALT (Nose/Nasal-Associated Lymphoid Tissue) system in the upper respiratory tract http://purl.obolibrary.org/obo/MP_0013224 absent second pharyngeal pouch http://purl.obolibrary.org/obo/MP_0013223 abnormal second pharyngeal pouch morphology absence of the second branchial pouch, normally located between the second and third branchial arches; the dorsal elongation of the second pouch endoderm of all mammals, with the exception of rodents, gives rise to the epithelial lining of palatine tonsils http://purl.obolibrary.org/obo/MP_0013225 abnormal third pharyngeal pouch morphology http://purl.obolibrary.org/obo/MP_0006031 abnormal pharyngeal pouch morphology any structural anomaly of the third endodermal branchial pouch located between the third and fourth branchial arches; in mammals, the cranial dorsal aspect of the third pouch generates the inferior parathyroids (or parathyroid III), whereas the caudal ventral part of the pouch gives rise to the thymus epithelium http://purl.obolibrary.org/obo/MP_0013226 absent third pharyngeal pouch http://purl.obolibrary.org/obo/MP_0013225 abnormal third pharyngeal pouch morphology absence of the third endodermal branchial pouch, normally located between the third and fourth branchial arches; in mammals, the cranial dorsal aspect of the third pouch generates the inferior parathyroids (or parathyroid III), whereas the caudal ventral part of the pouch gives rise to the thymus epithelium http://purl.obolibrary.org/obo/MP_0013227 small brain ventricles http://purl.obolibrary.org/obo/MP_0013229 abnormal brain ventricle size decreased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord http://purl.obolibrary.org/obo/MP_0013228 brain ventricle stenosis http://purl.obolibrary.org/obo/MP_0000822 abnormal brain ventricle morphology abnormal narrowing or constriction of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord http://purl.obolibrary.org/obo/MP_0013230 abnormal cervical sinus morphology http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology any structural anomaly of the temporary triangular depression found in the nuchal region caudal to the second (hyoid) branchial arch, and containing the succeeding branchial arches and grooves; the sinus is overgrown by the second branchial arch and is ultimately obliterated during extension of the cervical flexure http://purl.obolibrary.org/obo/MP_0013231 abnormal pharyngeal groove morphology http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology any structural anomaly of the ectodermally lined depressions (grooves or clefts) that separate the branchial arches externally on each side; only the first of the four pairs of branchial grooves persists in the adult to form the epithelium of the external auditory meatus and part of the tympanic membrane; the second, third, and fourth grooves are overlapped by the development of branchial arch 2 and form a slit-like depression known as the cervical sinus which is ultimately obliterated by the fusion of its walls during extension of the cervical flexure http://purl.obolibrary.org/obo/MP_0013232 abnormal pharyngeal membrane morphology http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology any structural anomaly of any of the four membranes that separate the branchial pouches from the corresponding branchial grooves in a developing embryo; each membrane is initially composed of an inner layer formed by the endodermal lining of a branchial pouch and an outer layer formed by the ectodermal lining of the branchial groove; later, these two layers become separated by a thin layer of mesoderm; only the first branchial membrane contributes to the formation of an adult structure, i.e. the tympanic membrane (aka eardrum); the second, third, and fourth membranes are obliterated http://purl.obolibrary.org/obo/MP_0013233 ectopic thyroid gland http://purl.obolibrary.org/obo/MP_0000681 abnormal thyroid gland morphology a thyroid gland located outside of its normal position anterior to the laryngeal cartilages; usually due to abnormal migration of the thyroid diverticulum down from the foramen cecum at the posterior aspect of the tongue to its permanent pre-tracheal location; ectopic thyroid tissue is frequently found along the course of the thyroglossal duct or laterally in the neck, as well as in distant places such as the mediastinum and the subdiaphragmatic organs; the most common ectopic location is near its embryological origin at the foramen caecum, resulting in a lingual thyroid http://purl.obolibrary.org/obo/MP_0013234 abnormal tongue foramen cecum morphology http://purl.obolibrary.org/obo/MP_0000762 abnormal tongue morphology any structural anomaly of the median pit on the dorsum of the posterior part of the tongue, from which the limbs of a V-shaped furrow run forward and outward; the foramen cecum is the point of attachment of the thyroglossal duct and is formed during the embryological descent of the thyroid gland http://purl.obolibrary.org/obo/MP_0013235 abnormal thyroglossal duct morphology http://purl.obolibrary.org/obo/MP_0003421 abnormal thyroid gland development any structural anomaly of the embryological anatomical structure that forms an open connection between the initial area of development of the thyroid gland and its final position; it is located exactly midline, between the anterior 2/3rds and posterior 1/3rd of the tongue; this duct normally atrophies and closes off as the foramen cecum before birth http://purl.obolibrary.org/obo/MP_0013236 ovary degeneration http://purl.obolibrary.org/obo/MP_0001126 abnormal ovary morphology a retrogressive impairment of function or destruction of one or both ovaries http://purl.obolibrary.org/obo/MP_0013237 abnormal skeletal muscle regeneration http://purl.obolibrary.org/obo/MP_0000750 abnormal muscle regeneration anomaly in the ability to repair skeletal muscle after injury or disease http://purl.obolibrary.org/obo/MP_0013238 abnormal cardiac muscle regeneration http://purl.obolibrary.org/obo/MP_0000750 abnormal muscle regeneration anomaly in the ability to repair cardiac muscle after injury or disease http://purl.obolibrary.org/obo/MP_0013239 impaired skeletal muscle regeneration http://purl.obolibrary.org/obo/MP_0013237 abnormal skeletal muscle regeneration reduced ability to repair skeletal muscle after injury or disease http://purl.obolibrary.org/obo/MP_0013240 impaired cardiac muscle regeneration http://purl.obolibrary.org/obo/MP_0013238 abnormal cardiac muscle regeneration reduced ability to repair cardiac muscle after injury or disease http://purl.obolibrary.org/obo/MP_0013241 embryo tissue necrosis http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0013242 abnormal amino acid metabolism http://purl.obolibrary.org/obo/MP_0005266 abnormal metabolism any anomaly in the chemical reactions and pathways involving an amino acid, including metabolic, catabolic and biosynthetic processes http://purl.obolibrary.org/obo/MP_0013243 abnormal carbohydrate metabolism http://purl.obolibrary.org/obo/MP_0005266 abnormal metabolism any anomaly in the chemical reactions and pathways involving a carbohydrate, including metabolic, catabolic and biosynthetic processes http://purl.obolibrary.org/obo/MP_0013247 placenta necrosis http://purl.obolibrary.org/obo/MP_0001711 abnormal placenta morphology morphological changes resulting from pathological death of placenta tissue; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0013248 placenta junctional zone necrosis http://purl.obolibrary.org/obo/MP_0013247 placenta necrosis morphological changes resulting from pathological death of placenta junctional zone tissue; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0013249 adipose tissue necrosis http://purl.obolibrary.org/obo/MP_0000003 abnormal adipose tissue morphology morphological changes resulting from pathological death of adipose tissue; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0013250 abnormal dental pulp morphology http://purl.obolibrary.org/obo/MP_0002100 abnormal tooth morphology any structural anomaly of the soft tissue within the pulp cavity located in the center of a tooth, comprised of living connective tissue containing blood vessels, nerves and lymphatics, and a layer of odontoblasts at the periphery, which participate in dentin repair http://purl.obolibrary.org/obo/MP_0013251 dental pulp necrosis http://purl.obolibrary.org/obo/MP_0013250 abnormal dental pulp morphology morphological changes resulting from pathological death of dental pulp tissue; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0013252 head mesenchyme necrosis http://purl.obolibrary.org/obo/MP_0013241 embryo tissue necrosis morphological changes resulting from pathological death of head mesenchyme tissue; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0013253 outer ear necrosis http://purl.obolibrary.org/obo/MP_0002177 abnormal outer ear morphology morphological changes resulting from pathological death of outer ear tissue; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0013255 abnormal circulating thrombin level http://purl.obolibrary.org/obo/MP_0005416 abnormal circulating protein level anomaly in the blood level of the a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions; it is generated from regulated proteolytic cleavage of prothrobmin during the coagulation cascade http://purl.obolibrary.org/obo/MP_0013256 increased circulating thrombin level http://purl.obolibrary.org/obo/MP_0013255 abnormal circulating thrombin level increased blood level of the a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions; it is generated from regulated proteolytic cleavage of prothrobmin during the coagulation cascade http://purl.obolibrary.org/obo/MP_0013257 decreased circulating thrombin level http://purl.obolibrary.org/obo/MP_0013255 abnormal circulating thrombin level reduction in the blood level of the a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions; it is generated from regulated proteolytic cleavage of prothrobmin during the coagulation cascade http://purl.obolibrary.org/obo/MP_0013259 abnormal dendritic cell apoptosis http://purl.obolibrary.org/obo/MP_0002376 abnormal dendritic cell physiology change in the timing or the number of dendritic cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0013260 decreased dendritic cell apoptosis http://purl.obolibrary.org/obo/MP_0013259 abnormal dendritic cell apoptosis reduction in the timing or the number of dendritic cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0013261 absent epiglottis http://purl.obolibrary.org/obo/MP_0010371 abnormal epiglottis morphology missing the most superior of the laryngeal cartilages, which is normally found at the root of the tongue and folds back over the entrance to the larynx during swallowing, preventing inhalation of food or drink http://purl.obolibrary.org/obo/MP_0013262 abnormal mouth floor morphology http://purl.obolibrary.org/obo/MP_0000452 abnormal mouth morphology any structural morphology of the ventral area of the mouth; in organisms with a tongue, a small horseshoe-shaped region situated beneath the movable part of the tongue and above the muscular diaphragm formed by the mylohyoid muscles; a median fold of mucous membrane, the lingual frenulum, connects the inferior surface of the tongue to the floor of the mouth http://purl.obolibrary.org/obo/MP_0013263 abnormal tongue frenulum morphology http://purl.obolibrary.org/obo/MP_0003745 abnormal mucosal lining of the mouth any structural anomaly of the small fold of mucous membrane extending from the floor of the mouth to the midline of the underside of the tongue http://purl.obolibrary.org/obo/MP_0013264 tongue ankylosis http://purl.obolibrary.org/obo/MP_0000762 abnormal tongue morphology partial or complete fusion or adherence of the tongue to the floor of the mouth, resulting in varying degrees of restricted tongue mobility; partial ankyloglossia (aka tongue-tie) is caused by a lingual frenulum that is abnormally short or is attached too close to the tip of the tongue; in complete ankyloglossia the tongue is tethered to the floor of the mouth http://purl.obolibrary.org/obo/MP_0013265 abnormal fourth pharyngeal pouch morphology http://purl.obolibrary.org/obo/MP_0006031 abnormal pharyngeal pouch morphology any structural anomaly of the fourth endodermal branchial pouch located between the fourth and sixth branchial arches (a fifth arch never establishes itself in amniotes); in most mammals, excluding rodents, the dorsal part of each fourth pouch develops into a superior parathyroid gland (parathyroid IV), which lies on the dorsal surface of the thyroid gland (the parathyroid glands derived from the third pouches descend with the thymus and are carried to a more inferior position than the parathyroid glands that are derived from the fourth pouches); the elongated ventral part of each fourth pouch develops into the ultimopharyngeal body, which fuses with the thyroid gland, giving rise to the calcitonin-producing parafollicular or C-cells of the thyroid gland http://purl.obolibrary.org/obo/MP_0013266 absent fourth pharynegal pouch http://purl.obolibrary.org/obo/MP_0013265 abnormal fourth pharyngeal pouch morphology absence of the fourth endodermal branchial pouch, normally located between the fourth and sixth branchial arches (a fifth arch never establishes itself in amniotes); in most mammals, excluding rodents, the dorsal part of each fourth pouch develops into a superior parathyroid gland (parathyroid IV), which lies on the dorsal surface of the thyroid gland; the elongated ventral part of each fourth pouch develops into the ultimopharyngeal body, which fuses with the thyroid gland, giving rise to the calcitonin-producing parafollicular or C-cells of the thyroid gland http://purl.obolibrary.org/obo/MP_0013267 first pharyngeal arch hypoplasia http://purl.obolibrary.org/obo/MP_0006341 small first pharyngeal arch underdevelopment or reduced size of the first pharyngeal arch, usually due to reduced cell number http://purl.obolibrary.org/obo/MP_0013268 second pharyngeal arch hypoplasia http://purl.obolibrary.org/obo/MP_0006344 small second pharyngeal arch underdevelopment or reduced size of the second pharyngeal arch, usually due to reduced cell number http://purl.obolibrary.org/obo/MP_0013269 third pharyngeal arch hypoplasia http://purl.obolibrary.org/obo/MP_0006339 abnormal third pharyngeal arch morphology underdevelopment or reduced size of the third pharyngeal arch, usually due to reduced cell number http://purl.obolibrary.org/obo/MP_0013270 fourth pharyngeal arch hypoplasia http://purl.obolibrary.org/obo/MP_0006340 abnormal fourth pharyngeal arch morphology underdevelopment or reduced size of the fourth pharyngeal arch, usually due to reduced cell number http://purl.obolibrary.org/obo/MP_0013271 sixth pharyngeal arch hypoplasia http://purl.obolibrary.org/obo/MP_0006347 abnormal sixth pharyngeal arch morphology underdevelopment or reduced size of the fourth pharyngeal arch, usually due to reduced cell number http://purl.obolibrary.org/obo/MP_0013272 abnormal translation http://purl.obolibrary.org/obo/MP_0005621 abnormal cell physiology any anomaly in the cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain; translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA; translation ends with the release of a polypeptide chain from the ribosome http://purl.obolibrary.org/obo/MP_0013273 abnormal translational elongation http://purl.obolibrary.org/obo/MP_0013272 abnormal translation any anomaly in the process of successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis http://purl.obolibrary.org/obo/MP_0013274 abnormal vitamin or vitamin cofactor metabolism http://purl.obolibrary.org/obo/MP_0005266 abnormal metabolism any anomaly in the chemical reactions and pathways involving a vitamin or cofactor, including metabolic, catabolic and biosynthetic processes http://purl.obolibrary.org/obo/MP_0013275 abnormal xenobiotic metabolism http://purl.obolibrary.org/obo/MP_0005266 abnormal metabolism any anomaly in the chemical reactions and pathways involving a xenobiotic, including metabolic, catabolic and biosynthetic processes http://purl.obolibrary.org/obo/MP_0013276 absent alpha-beta T cells http://purl.obolibrary.org/obo/MP_0012765 decreased alpha-beta T cell number absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation and express an alpha-beta T cell receptor complex http://purl.obolibrary.org/obo/MP_0013277 abnormal fasted circulating glucose level http://purl.obolibrary.org/obo/MP_0000188 abnormal circulating glucose level any anomaly in the amount of glucose in the blood at some defined time point after eating compared to controls http://purl.obolibrary.org/obo/MP_0013278 decreased fasted circulating glucose level http://purl.obolibrary.org/obo/MP_0013277 abnormal fasted circulating glucose level reduction in the amount of glucose in the blood at some defined time point after eating compared to controls http://purl.obolibrary.org/obo/MP_0013279 increased fasted circulating glucose level http://purl.obolibrary.org/obo/MP_0013277 abnormal fasted circulating glucose level increase in the amount of glucose in the blood at some defined time point after eating compared to controls http://purl.obolibrary.org/obo/MP_0013281 increased cytotoxic T cell cytolysis http://purl.obolibrary.org/obo/MP_0013280 abnormal cytotoxic T cell cytolysis increased ability of cytotoxic T cells to induce pathological breakdown of target cells http://purl.obolibrary.org/obo/MP_0013282 urinary bladder exstrophy http://purl.obolibrary.org/obo/MP_0000757 herniated abdominal wall a herniation of the urinary bladder through an anterior abdominal wall defect; refers to congenital absence of a portion of the lower anterior abdominal wall and the anterior urinary bladder wall, with eversion of the posterior bladder wall through the defect, an open pubic arch, and widely separated ischia connected by a fibrous band http://purl.obolibrary.org/obo/MP_0013283 failure of ventral body wall closure http://purl.obolibrary.org/obo/MP_0003384 abnormal ventral body wall morphology failure of the lateral body wall folds (a combination of mesoderm and ectoderm arising on each side of the embryo) to progress ventrally and meet in the midline and/or fuse to close the ventral body wall; normally, this closure is aided by growth of the head and tail folds that cause the embryo to curve into the fetal position and is complete except in the region of the connecting stalk (future umbilical cord); if closure fails, ventral body wall defects occur in the thorax, abdomen, and pelvis and involve the heart (ectopia cordis), abdominal viscera (gastroschisis), and/or urogenital organs (bladder or cloacal exstrophy), depending upon the location and size of the abnormality http://purl.obolibrary.org/obo/MP_0013288 premature acrosome reaction http://purl.obolibrary.org/obo/MP_0013287 abnormal acrosome reaction spontaneous initiation of the cellular exocytosis that allows sperm to penetrate the zona pellucida of ovulated eggs, occurring prior to encountering conditions that induce sperm capacitation http://purl.obolibrary.org/obo/MP_0013289 abnormal mitotic cytokinesis http://purl.obolibrary.org/obo/MP_0004046 abnormal mitosis any anomaly in the process that results in the division of the cytoplasm of a cell after mitosis, this process consists of two distinct processes furrowing and abscission http://purl.obolibrary.org/obo/MP_0013290 persistent ultimobranchial bodies http://purl.obolibrary.org/obo/MP_0003955 abnormal ultimobranchial body morphology partial or complete failure of the ultimobranchial bodies to fuse with the ventral thyroid primordium; as a result, ultimobranchial bodies remain as unilateral or bilateral vesicles composed exclusively of calcitonin-producing cells http://purl.obolibrary.org/obo/MP_0013291 ectopic pancreas http://purl.obolibrary.org/obo/MP_0001944 abnormal pancreas morphology presence of well-developed and normally organized pancreatic tissue lying outside its normal location without any anatomical and vascular continuity with the pancreas proper; although an ectopic pancreas can occur throughout the entire gastrointestinal tract, it is most commonly located in the stomach, duodenum, jejunum or Meckel's diverticulum http://purl.obolibrary.org/obo/MP_0013293 embryonic lethality prior to tooth bud stage http://purl.obolibrary.org/obo/MP_0008762 embryonic lethality death prior to the appearance of tooth buds (Mus: E12-E12.5) http://purl.obolibrary.org/obo/MP_0013294 prenatal lethality prior to heart atrial septation http://purl.obolibrary.org/obo/MP_0002080 prenatal lethality death prior to the completion of heart atrial septation (Mus: E14.5-15.5) http://purl.obolibrary.org/obo/MP_0013297 abnormal susceptibility to colitis induced morbidity/mortality http://purl.obolibrary.org/obo/MP_0013296 abnormal susceptibility to induced colitis differences from the expected moribund state caused by colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS) http://purl.obolibrary.org/obo/MP_0013298 increased susceptibility to colitis induced morbidity/mortality http://purl.obolibrary.org/obo/MP_0013297 abnormal susceptibility to colitis induced morbidity/mortality increased likelihood that an organism will display the expected moribund state caused by colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS) http://purl.obolibrary.org/obo/MP_0013299 decreased susceptibility to colitis induced morbidity/mortality http://purl.obolibrary.org/obo/MP_0013297 abnormal susceptibility to colitis induced morbidity/mortality reduced likelihood that an organism will display the expected moribund state caused by colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS) http://purl.obolibrary.org/obo/MP_0013301 abnormal pancreas iron level http://purl.obolibrary.org/obo/MP_0001944 abnormal pancreas morphology anomaly in the amount of iron present in the liver tissue http://purl.obolibrary.org/obo/MP_0013302 increased pancreas iron level http://purl.obolibrary.org/obo/MP_0013301 abnormal pancreas iron level increase in the amount of iron present in the pancreas tissue http://purl.obolibrary.org/obo/MP_0013303 decreased pancreas iron level http://purl.obolibrary.org/obo/MP_0013301 abnormal pancreas iron level reduction in the amount of iron present in the pancreas tissue http://purl.obolibrary.org/obo/MP_0013304 osteophytes http://purl.obolibrary.org/obo/MP_0003795 abnormal bone structure bony projections that form along joint margins at bone edges, including the spine; these are frequently found in areas affected by arthritis such as the disc or joint spaces where cartilage has deteriorated http://purl.obolibrary.org/obo/MP_0013305 isosthenuria http://purl.obolibrary.org/obo/MP_0002136 abnormal kidney physiology inability of the kidneys to produce either a concentrated or a dilute urine; refers to a state in chronic renal disease in which the kidney cannot form urine with a higher or a lower specific gravity (concentration) than that of protein-free plasma; the specific gravity of the urine becomes fixed, irrespective of the fluid intake http://purl.obolibrary.org/obo/MP_0013307 increased adrenal gland weight http://purl.obolibrary.org/obo/MP_0012689 abnormal adrenal gland weight greater average weight of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla http://purl.obolibrary.org/obo/MP_0013308 decreased adrenal gland weight http://purl.obolibrary.org/obo/MP_0012689 abnormal adrenal gland weight reduced average weight of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla http://purl.obolibrary.org/obo/MP_0013309 adrenal gland cyst http://purl.obolibrary.org/obo/MP_0000639 abnormal adrenal gland morphology presence of fluid-filled usually benign growths in the adrenal gland http://purl.obolibrary.org/obo/MP_0013310 abnormal adrenal gland development http://purl.obolibrary.org/obo/MP_0000639 abnormal adrenal gland morphology aberrant formation or incomplete differentiation of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla http://purl.obolibrary.org/obo/MP_0013311 abnormal ovary capsule morphology http://purl.obolibrary.org/obo/MP_0001126 abnormal ovary morphology any structural anomaly of the tough, fibrous capsule surrounding each ovary http://purl.obolibrary.org/obo/MP_0013312 absent ovary capsule http://purl.obolibrary.org/obo/MP_0013311 abnormal ovary capsule morphology missing the tough, fibrous capsule surrounding each ovary http://purl.obolibrary.org/obo/MP_0013313 female preputial gland hypoplasia http://purl.obolibrary.org/obo/MP_0013193 sebaceous gland hypoplasia underdevelopment or reduced size, usually due to a reduced number of cells, of any of the paired, lobulated, modified sebaceous glands located on the side of the clitoris in female rodents http://purl.obolibrary.org/obo/MP_0013314 abnormal eumelanosome morphology http://purl.obolibrary.org/obo/MP_0005075 abnormal melanosome morphology any structural anomaly of the elliptical-shaped pigment organelles that synthesize and store eumelanin (black/brown) pigment, which is deposited in smooth laminated fibrils of mature eumelanosomes http://purl.obolibrary.org/obo/MP_0013315 abnormal pheomelanosome morphology http://purl.obolibrary.org/obo/MP_0005075 abnormal melanosome morphology any structural anomaly of the oval-shaped pigment organelles that synthesize and store pheomelanin (yellow) pigment, which is deposited in dense granular deposits within pheomelanosomes http://purl.obolibrary.org/obo/MP_0013317 abnormal seminal vesicle development http://purl.obolibrary.org/obo/MP_0003936 abnormal reproductive system development aberrant or incomplete differentiation of either of the paired sac-like glandular structures situated posterolateral to the urinary bladder in the male and functioning as part of the reproductive system; seminal vesicles develop from the segments of the Wolffian ducts immediately adjacent to the urogenital sinus http://purl.obolibrary.org/obo/MP_0013318 abnormal branching involved in seminal vesicle morphogenesis http://purl.obolibrary.org/obo/MP_0013317 abnormal seminal vesicle development anomaly in the process in which the seminal vesicle is generated and organized in many mammals including mice and humans; in mice, the initial seminal vesicle buds form cane-shaped tubes off of the Wolffian ducts before birth; after birth, the initial tubes develop lateral branches that elongate and often undergo secondary branching morphogenesis; branching morphogenesis is largely complete by 2 weeks of age http://purl.obolibrary.org/obo/MP_0013319 seminal vesicle atrophy http://purl.obolibrary.org/obo/MP_0002059 abnormal seminal vesicle morphology acquired size diminution of the seminal vesicles, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0013320 dilated seminal vesicles http://purl.obolibrary.org/obo/MP_0002059 abnormal seminal vesicle morphology an expansion in the lumen volume of either of the paired sac-like glandular structures situated posterolateral to the urinary bladder in the male and functioning as part of the reproductive system, as by stretching or distention http://purl.obolibrary.org/obo/MP_0013321 squamous metaplasia of seminal vesicles http://purl.obolibrary.org/obo/MP_0002059 abnormal seminal vesicle morphology a benign non-cancerous transformation of the pseudostratified columnar epithelium lining the seminal vesicle(s) into stratified squamous epithelium; may occur in response to irritation or inflammation and involve keratinization http://purl.obolibrary.org/obo/MP_0013322 squamous metaplasia of prostate gland http://purl.obolibrary.org/obo/MP_0001158 abnormal prostate gland morphology a benign non-cancerous transformation of the prostatic glandular epithelium into stratified squamous epithelium http://purl.obolibrary.org/obo/MP_0013323 abnormal ampullary gland morphology http://purl.obolibrary.org/obo/MP_0013330 abnormal male accessory sex gland morphology any structural anomaly of the paired accessory, glandular, androgen-dependent outpouchings of the proximal ductus deferens, one on each side, that produce and secrete lipids and glycogen, components of the seminal fluid; they open into the ampullae at the level of the colliculus seminalis, are lined by simple columnar epithelium with large, oval nuclei, and may be distinguished from those of the prostate as they are surrounded by a characteristic, dense, fibromuscular stroma; the epithelium forms longitudinal folds and the glands contain homogeneous, dense, eosinophilic secretions with characteristic holes that impart a Swiss cheese-like appearance http://purl.obolibrary.org/obo/MP_0013328 visceromegaly http://purl.obolibrary.org/obo/MP_0005378 growth/size/body phenotype abnormal enlargement of the viscera, esp. internal organs in the abdomen, including liver, spleen, stomach, kidneys, and pancreas http://purl.obolibrary.org/obo/MP_0013331 abnormal lacrimal gland development http://purl.obolibrary.org/obo/MP_0001346 abnormal lacrimal gland morphology aberrant formation or incomplete differentiation of the paired almond-shaped glands, one for each eye, that secrete the aqueous layer of the tear film; each lacrimal gland develops through branching morphogenesis regulated by FGF signaling; at E12.5, the conjunctival epithelium at the temporal side of the mouse eyes invades the Fgf10-expressing mesenchyme to form the initial lacrimal gland bud; the bud elongates posteriorly until E15.5 when secondary branching begins to establish the complex tubuloalveolar structure; this eventually gives rise to the mature lacrimal gland composed of numerous ducts, acini and connective tissue http://purl.obolibrary.org/obo/MP_0013332 peliosis http://purl.obolibrary.org/obo/MP_0002127 abnormal cardiovascular system morphology presence of multiple cyst-like blood-filled lakes or cavities that lack endothelial linings within parenchymatous organs, typically found in the liver, spleen, bone marrow and lymph nodes; also described in other organs such as lungs, kidneys, parathyroids and pancreas http://purl.obolibrary.org/obo/MP_0013333 pituitary gland peliosis http://purl.obolibrary.org/obo/MP_0013332 peliosis presence of cyst-like blood-filled lakes or cavities (extravasated erythrocytes not contained in capillaries) within the pituitary gland; commonly found in hyperplastic and adenomatous pituitary glands http://purl.obolibrary.org/obo/MP_0013334 adenohypophysis peliosis http://purl.obolibrary.org/obo/MP_0013333 pituitary gland peliosis presence of cyst-like blood-filled lakes or cavities (extravasated erythrocytes not contained in capillaries) within the anterior lobe of the pituitary gland http://purl.obolibrary.org/obo/MP_0013335 hepatic peliosis http://purl.obolibrary.org/obo/MP_0013332 peliosis presence of cyst-like blood-filled lakes or cavities that lack endothelial linings in the liver parenchyma http://purl.obolibrary.org/obo/MP_0013336 pituitary gland hypertrophy http://purl.obolibrary.org/obo/MP_0000636 enlarged pituitary gland increase in the bulk size of the pituitary gland due to cell enlargement http://purl.obolibrary.org/obo/MP_0013338 abnormal neurohypophysis development http://purl.obolibrary.org/obo/MP_0004164 abnormal neurohypophysis morphology aberrant formation or incomplete differentiation of the posterior lobe of the pituitary gland which develops as a neurohypophyseal bud, a depression in the neuroectoderm of the floor of the hypothalamus; the infundibulum, another diverticulum from the inferior aspect of the diencephalon, develops as an outgrowth of the neurohypophyseal bud and connects the neurohypophysis to the hypothalamus; the neurohypophysis develops as the infundibulum grows inferiorly from the diencephalon to meet the developing adenohypophysis (anterior pituitary lobe); the fully developed neurohypophysis consists of the infundibulum and the pars nervosa; the neural connection between the hypothalamus and pars nervosa is through the hypothalamohypophyseal tract that develops within the infundibulum http://purl.obolibrary.org/obo/MP_0013339 abnormal neurohypophyseal bud morphology http://purl.obolibrary.org/obo/MP_0003816 abnormal pituitary gland development any structural anomaly of the outgrowth of neuroectoderm located on the floor of the embryonic hypothalamus that gives rise to the neurohypophysis (posterior lobe) of the pituitary gland http://purl.obolibrary.org/obo/MP_0013340 abnormal pituicyte morphology http://purl.obolibrary.org/obo/MP_0004164 abnormal neurohypophysis morphology any structural anomaly of the distinctive fusiform cells present in the pars nervosa of the posterior pituitary gland which resemble astrocytes/glial cells of the CNS and assist in the storage and release of neurohypophysial hormones http://purl.obolibrary.org/obo/MP_0013341 abnormal folliculo-stellate cell morphology http://purl.obolibrary.org/obo/MP_0004163 abnormal adenohypophysis morphology any structural anomaly of the star-shaped and follicle-forming cells in the anterior pituitary gland that stain positive for S-100 protein (a marker for FS-cells); ascribed functions include the formation of an extensive and complex tridimentional network, scavenger activity by engulfing degenerated cells, paracrine regulation of endocrine cells by producing various growth factors and cytokines, such as interleukin-6, leukemia inhibitory factor, basic fibroblastic growth factor, vascular endothelial cell growth factor and follistatin, and large-scale inter-cellular communication by means of their long cytoplasmic processes and gap junctions http://purl.obolibrary.org/obo/MP_0013342 bifurcated Rathke's pouch http://purl.obolibrary.org/obo/MP_0003817 abnormal pituitary diverticulum morphology the appearance of an abnormal division in the diverticulum arsing from the embryonic buccal cavity from which the anterior lobe of the pituitary gland is developed http://purl.obolibrary.org/obo/MP_0013343 abnormal pituitary gland apoptosis http://purl.obolibrary.org/obo/MP_0005646 abnormal pituitary gland physiology change in the timing or the number of any pituitary gland cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0013344 increased pituitary gland apoptosis http://purl.obolibrary.org/obo/MP_0013343 abnormal pituitary gland apoptosis increase in the number of any cells of the pituitary gland undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0013345 decreased pituitary gland apoptosis http://purl.obolibrary.org/obo/MP_0013343 abnormal pituitary gland apoptosis decrease in the number of any cells of the pituitary gland undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0013346 increased melanotroph apoptosis http://purl.obolibrary.org/obo/MP_0013344 increased pituitary gland apoptosis increase in the number of cells of the intermediate pituitary that produce melanocyte stimulating hormone and other peptides from the post-translational processing of pro-opiomelanocortin (POMC) undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0013347 increased corticotroph apoptosis http://purl.obolibrary.org/obo/MP_0013344 increased pituitary gland apoptosis increase in the number of anterior pituitary ACTH-producing basophilic cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0013348 adenohypophysis hyperplasia http://purl.obolibrary.org/obo/MP_0008366 enlarged adenohypophysis overdevelopment or increased size of the anterior lobe of the pituitary gland, usually due to increased cell number http://purl.obolibrary.org/obo/MP_0013349 small Rathke's pouch http://purl.obolibrary.org/obo/MP_0003817 abnormal pituitary diverticulum morphology reduced size of the pouch of ectoderm which grows out from the upper surface of the embryonic stomodeum and gives rise to the anterior and intermediate lobes of the pituitary gland http://purl.obolibrary.org/obo/MP_0013350 Rathke's pouch hypoplasia http://purl.obolibrary.org/obo/MP_0013349 small Rathke's pouch underdevelopment or reduced size of Rathke's pouch, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0013351 abnormal Rathke's pouch development http://purl.obolibrary.org/obo/MP_0003817 abnormal pituitary diverticulum morphology any anomaly in the formation of the pouch of ectoderm which grows out from the upper surface of the embryonic stomodeum and gives rise to the anterior and intermediate lobes of the pituitary gland http://purl.obolibrary.org/obo/MP_0013352 abnormal Rathke's pouch apoptosis http://purl.obolibrary.org/obo/MP_0003817 abnormal pituitary diverticulum morphology any change in the timing or number of Rathke's pouch cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0013353 Rathke cleft cyst http://purl.obolibrary.org/obo/MP_0003817 abnormal pituitary diverticulum morphology an intrasellar or suprasellar cyst lined by cuboidal epithelium derived from remnants of the Rathke pouch http://purl.obolibrary.org/obo/MP_0013354 increased Rathke pouch tumor incidence http://purl.obolibrary.org/obo/MP_0010320 increased pituitary gland tumor incidence a suprasellar neoplasm, usually cystic, that develops from the nests of epithelium derived from Rathke pouch http://purl.obolibrary.org/obo/MP_0013355 adenohypophysis hypertrophy http://purl.obolibrary.org/obo/MP_0008366 enlarged adenohypophysis increase in the bulk size of the anterior lobe of the pituitary gland due to cell enlargement http://purl.obolibrary.org/obo/MP_0013356 ectopic pituitary gland http://purl.obolibrary.org/obo/MP_0000633 abnormal pituitary gland morphology a pituitary gland located outside of its normal position http://purl.obolibrary.org/obo/MP_0013357 ectopic adenohypophysis http://purl.obolibrary.org/obo/MP_0004163 abnormal adenohypophysis morphology an anterior pituitary gland located outside of its normal position due to arrest of migration from a pharyngeocranial location to the sellar region; a portion or all of the adenohypophysis may persist in the pathway of the pharyngeal pouch, either in the nasopharyngeal wall or within the sphenoid bone http://purl.obolibrary.org/obo/MP_0013358 ectopic neurohypophysis http://purl.obolibrary.org/obo/MP_0004164 abnormal neurohypophysis morphology a posterior pituitary gland displaced distally in the infundibulum (pituitary stalk) due to defective neuronal migration during embryogenesis, tumors, trauma, or surgical transection of the pituitary stalk; may present with an empty pituitary fossa, hypoplasia or absence of the infundibular stalk and resultant short stature due to growth hormone deficiency; the location of the ectopic lobe can vary, but it is most commonly located along the median eminence in the floor of the third ventricle http://purl.obolibrary.org/obo/MP_0013359 abnormal pinealocyte morphology http://purl.obolibrary.org/obo/MP_0000632 abnormal pineal gland morphology any structural anomaly of the principal cell of the pineal gland, characterized by two or more long cell processes ending in bulbous expansions that terminate in perivascular spaces surrounding capillaries; pinealocytes are secretory cells organized into cords and clusters resting on a basal lamina and surrounded by connective tissue, blood vessels lined by fenestrated endothelial cells, and nerves; their cytoplasm contains abundant mitochondria and multiple synaptic ribbons that are randomly distributed; the primary function of the pinealocytes is the secretion of melatonin; pinealocytes receive a direct innervation from sympathetic neurons that form recognizable synapses http://purl.obolibrary.org/obo/MP_0013360 abnormal pineal recess morphology http://purl.obolibrary.org/obo/MP_0000826 abnormal third ventricle morphology any structural anomaly of the diverticulum of the thin roof of the dorsocaudal third ventricle that projects into the stalk of the pineal gland http://purl.obolibrary.org/obo/MP_0013361 absent pineal recess http://purl.obolibrary.org/obo/MP_0013360 abnormal pineal recess morphology absence of the diverticulum of the thin roof of the dorsocaudal third ventricle that projects into the stalk of the pineal gland http://purl.obolibrary.org/obo/MP_0013362 absent pineal gland http://purl.obolibrary.org/obo/MP_0000632 abnormal pineal gland morphology absence of the unpaired epithalamic structure that is shaped like a tiny pine cone and located above the posterior commissure near the level of the habenular complex and the sylvian aqueduct; the pineal is both a circumventricular organ and an endocrine organ that secretes melatonin, a serotonin-derived hormone involved in the regulation of circadian rhythms http://purl.obolibrary.org/obo/MP_0013363 abnormal pineal gland development http://purl.obolibrary.org/obo/MP_0000632 abnormal pineal gland morphology aberrant formation or incomplete differentiation of the pineal gland which normally develops from a saccular outpocketing of the posterior diencephalic roof in the midline of the third ventricle; continued diverticulation and infolding result in a solid parenchymal mass of cords and clusters of pinealocytes and glial-like interstitial cells supported by a meninges-derived connective tissue that carries blood vessels and nerves to the pineal gland http://purl.obolibrary.org/obo/MP_0013364 enlarged pineal gland http://purl.obolibrary.org/obo/MP_0000632 abnormal pineal gland morphology increased size of the unpaired epithalamic structure that is shaped like a tiny pine cone and located above the posterior commissure near the level of the habenular complex and the sylvian aqueduct; the pineal is both a circumventricular organ and an endocrine organ that secretes melatonin, a serotonin-derived hormone involved in the regulation of circadian rhythms http://purl.obolibrary.org/obo/MP_0013365 increased pineal gland tumor incidence http://purl.obolibrary.org/obo/MP_0010288 increased gland tumor incidence greater than the expected number of neoplams in the pineal gland occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0013366 adrenal gland atrophy http://purl.obolibrary.org/obo/MP_0000639 abnormal adrenal gland morphology acquired diminution of the size of the pair of endocrine glands located above the kidney and responsible for steroid hormone secretion from the cortex and neurotransmitter secretion from the medulla, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0013367 parotid gland inflammation http://purl.obolibrary.org/obo/MP_0001870 salivary gland inflammation local accumulation of fluid, plasma proteins, and leukocytes in either of the largest of the major salivary glands situated below and in front of each ear http://purl.obolibrary.org/obo/MP_0013368 abnormal sweat gland physiology http://purl.obolibrary.org/obo/MP_0010680 abnormal skin adnexa physiology any functional anomaly of the coiled tubular glands of the skin that secrete sweat http://purl.obolibrary.org/obo/MP_0013369 abnormal sweat gland secretion http://purl.obolibrary.org/obo/MP_0013368 abnormal sweat gland physiology altered ability of the coiled tubular glands of the skin to produce or secrete sweat in response to appropriate stimuli http://purl.obolibrary.org/obo/MP_0013370 anhidrosis http://purl.obolibrary.org/obo/MP_0013369 abnormal sweat gland secretion complete absence of sweating in response to appropriate stimuli http://purl.obolibrary.org/obo/MP_0013371 hypohidrosis http://purl.obolibrary.org/obo/MP_0013369 abnormal sweat gland secretion decreased sweating in response to appropriate stimuli http://purl.obolibrary.org/obo/MP_0013372 hyperhidrosis http://purl.obolibrary.org/obo/MP_0013369 abnormal sweat gland secretion abnormally increased sweating in response to appropriate stimuli http://purl.obolibrary.org/obo/MP_0013373 increased sebum secretion http://purl.obolibrary.org/obo/MP_0002991 abnormal sebaceous gland physiology increased production and/or release of the lipid-rich substance that is produced by the sebaceous glands, acts to lubricate and waterproof the skin and hair of mammals, and provides antibacterial activity; sebum is released by disintegrating sebocytes that are continuously replaced from progenitors in the periphery of the sebaceous gland; its composition varies across species http://purl.obolibrary.org/obo/MP_0013374 increased sebaceous gland tumor incidence http://purl.obolibrary.org/obo/MP_0010288 increased gland tumor incidence greater than the expected number of neoplams in the sebaceous gland occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0013375 abnormal sebocyte morphology http://purl.obolibrary.org/obo/MP_0000647 abnormal sebaceous gland morphology any structural anomaly of the highly specialized, sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation (holocrine secretion); these cells are most commonly found in the skin in association with hair follicles (forming the pilosebaceous unit), where they arise from hair follicle keratinocytes, but there are also sebaceous glands not associated with a hair follicle; the latter have special functions as secretion of pheromones or corneal protection http://purl.obolibrary.org/obo/MP_0013376 abnormal sebocyte differentiation http://purl.obolibrary.org/obo/MP_0013375 abnormal sebocyte morphology abnormal formation or arrest of differentiation of the sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation; these cells are most commonly found in the skin in association with hair follicles (forming the pilosebaceous unit), where they arise from hair follicle keratinocytes, but there are also sebaceous glands not associated with a hair follicle; the latter have special functions as secretion of pheromones or corneal protection; sebocyte differentiation is defined by increasing accumulation of lipid droplets, the major component of sebum http://purl.obolibrary.org/obo/MP_0013377 abnormal sebocyte number http://purl.obolibrary.org/obo/MP_0013375 abnormal sebocyte morphology any deviation from the normal numbers of the highly specialized, sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation http://purl.obolibrary.org/obo/MP_0013378 increased sebocyte number http://purl.obolibrary.org/obo/MP_0013377 abnormal sebocyte number greater than expected number of the highly specialized, sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation http://purl.obolibrary.org/obo/MP_0013379 decreased sebocyte cell number http://purl.obolibrary.org/obo/MP_0013377 abnormal sebocyte number fewer than expected number of the highly specialized, sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation http://purl.obolibrary.org/obo/MP_0013380 absent sebocyte http://purl.obolibrary.org/obo/MP_0013379 decreased sebocyte cell number failure of formation or loss of the highly specialized, sebum-producing epithelial cells of the sebaceous glands that release their content by rupture of the cell membrane and cellular degradation http://purl.obolibrary.org/obo/MP_0013381 abnormal perianal sebaceous gland morphology http://purl.obolibrary.org/obo/MP_0000647 abnormal sebaceous gland morphology any structural anomaly of the modified holocrine gland that is part of the pilosebaceous unit of a hair located in the area around the anus; each of the specialized large hair follicles that surround and form a network around the anus has a pair of large sebaceous glands that empty into the follicle; perianal glands may function as scent glands http://purl.obolibrary.org/obo/MP_0013382 small perianal sebaceous gland http://purl.obolibrary.org/obo/MP_0013381 abnormal perianal sebaceous gland morphology decreased size of the modified holocrine gland that is part of the pilosebaceous unit of a hair located in the area around the anus; each of the specialized large hair follicles that surround and form a network around the anus has a pair of large sebaceous glands that empty into the follicle; perianal glands may function as scent glands http://purl.obolibrary.org/obo/MP_0013383 increased sebaceous gland adenoma incidence http://purl.obolibrary.org/obo/MP_0013374 increased sebaceous gland tumor incidence greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in any sebaceous gland, occurring in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0013384 abnormal Zymbal's gland morphology http://purl.obolibrary.org/obo/MP_0000647 abnormal sebaceous gland morphology any structural anomaly of either of the paired multilobulated modified auditory sebaceous glands located anterior and ventral to the exterior ear canal in rodents; each gland consists of acinar sebaceous cells and excretory ducts lined by stratified squamous epithelium; the ducts of Zymbal's gland empty into the external ear canal http://purl.obolibrary.org/obo/MP_0013385 abnormal Meibomian gland development http://purl.obolibrary.org/obo/MP_0005252 abnormal Meibomian gland morphology aberrant formation or incomplete differentiation of the sebaceous glands located at the rim of the eyelids inside the tarsal plate and responsible for the supply of meibum, an oily substance that prevents evaporation of the eye's tear film; in mice, meibomian gland development is initiated around E18.5 with the formation of an epithelial placode and mesenchymal condensation, similar to that observed in hair follicle development; invagination of the epithelium into the developing mesenchyme then continues from birth to about P3 with initial branching of the epithelial cord detected at P5; by P8 the developing meibomian gland shows extensive ductal branching and the formation of distinct acini with mature meibomian glands present by P15 or eyelid opening http://purl.obolibrary.org/obo/MP_0013386 enlarged Meibomian gland http://purl.obolibrary.org/obo/MP_0005252 abnormal Meibomian gland morphology increased size of the meibum-secreting modified lobulated sebaceous glands located at the rim of the eyelids inside the tarsal plate http://purl.obolibrary.org/obo/MP_0013387 Meibomian gland hypertrophy http://purl.obolibrary.org/obo/MP_0013386 enlarged Meibomian gland increase in the bulk size of the meibum-secreting modified lobulated sebaceous glands located at the rim of the eyelids inside the tarsal plate due to cell enlargement http://purl.obolibrary.org/obo/MP_0013388 small Meibomian gland http://purl.obolibrary.org/obo/MP_0005252 abnormal Meibomian gland morphology decreased size of the meibum-secreting modified lobulated sebaceous glands located at the rim of the eyelids inside the tarsal plate http://purl.obolibrary.org/obo/MP_0013389 Meibomian gland hypoplasia http://purl.obolibrary.org/obo/MP_0013388 small Meibomian gland underdevelopment or reduced size of the meibum-secreting modified lobulated sebaceous glands located at the rim of the eyelids inside the tarsal plate, usually due to a reduced number of cells http://purl.obolibrary.org/obo/MP_0013390 Meibomian gland cyst http://purl.obolibrary.org/obo/MP_0005252 abnormal Meibomian gland morphology a non-malignant fluid-filled swelling (cyst) of the eyelid area due to non-infectious obstruction or malfunctioning of a Meibomian gland causing extravasation of lipid material in the eyelid soft tissues with focal secondary granulomatous inflammation http://purl.obolibrary.org/obo/MP_0013391 abnormal Meibomian gland physiology http://purl.obolibrary.org/obo/MP_0002991 abnormal sebaceous gland physiology any functional anomaly of the meibum-secreting modified lobulated sebaceous glands located at the rim of the eyelids inside the tarsal plate; dysfunctional Meibomian glands may produce an excessive amount of oil, cause dry eyes, or contribute to blepharitis http://purl.obolibrary.org/obo/MP_0013392 Meibomian gland inflammation http://purl.obolibrary.org/obo/MP_0013391 abnormal Meibomian gland physiology local accumulation of fluid, plasma proteins, and leukocytes in the meibum-secreting modified lobulated sebaceous glands located at the rim of the eyelids inside the tarsal plate; chronic Meibomian gland inflammation can lead to a lump in the eyelid known as a Meibomian gland cyst (aka chalazion) http://purl.obolibrary.org/obo/MP_0013393 symblepharon http://purl.obolibrary.org/obo/MP_0013402 abnormal bulbar conjunctiva morphology partial or complete adhesion of the palpebral conjunctiva of the eyelid to the bulbar conjunctiva of the eyeball http://purl.obolibrary.org/obo/MP_0013394 abnormal palpebral conjunctiva morphology http://purl.obolibrary.org/obo/MP_0001340 abnormal eyelid morphology any structural anomaly of the thin transparent mucous membrane that covers the posterior surface of the eyelids and is continuous with the bulbar conjunctiva at the conjunctival fornicies http://purl.obolibrary.org/obo/MP_0013395 eyelid hypoplasia http://purl.obolibrary.org/obo/MP_0001340 abnormal eyelid morphology underdevelopment or reduced size of the skin folds covering the front of the eyeball, usually due to a decreased cell number http://purl.obolibrary.org/obo/MP_0013396 eyelid hyperplasia http://purl.obolibrary.org/obo/MP_0001340 abnormal eyelid morphology overdevelopment or increased size of the skin folds covering the front of the eyeball, usually due to an increased cell number http://purl.obolibrary.org/obo/MP_0013397 abnormal Zeis gland morphology http://purl.obolibrary.org/obo/MP_0009535 abnormal skin sebaceous gland morphology any structural anomaly of the unilobar sebaceous glands located on the margin of the eyelid that service the eyelash; these glands produce an oily substance that is issued through the excretory ducts of the sebaceous lobule into the middle portion of the hair follicle http://purl.obolibrary.org/obo/MP_0013398 uterus fibrosis http://purl.obolibrary.org/obo/MP_0001120 abnormal uterus morphology invasion of fibrous connective tissue into the uterus, often resulting from inflammation or injury http://purl.obolibrary.org/obo/MP_0013399 endometrium fibrosis http://purl.obolibrary.org/obo/MP_0013398 uterus fibrosis invasion of fibrous connective tissue into the endometrium, often resulting from inflammation or injury http://purl.obolibrary.org/obo/MP_0013400 abnormal endometrial gland development http://purl.obolibrary.org/obo/MP_0009094 abnormal endometrial gland morphology aberrant formation or incomplete differentiation of the simple or branched tubular glands found in the mucus membrane of the uterus http://purl.obolibrary.org/obo/MP_0013401 increased endometrial gland number http://purl.obolibrary.org/obo/MP_0009095 abnormal endometrial gland number greater than normal numbers of the simple or branched tubular glands found in the mucus membrane of the uterus http://purl.obolibrary.org/obo/MP_0013402 abnormal bulbar conjunctiva morphology http://purl.obolibrary.org/obo/MP_0001310 abnormal conjunctiva morphology any structural anomaly of the conjunctiva covering the anterior surface of the sclera and the surface epithelium of the cornea http://purl.obolibrary.org/obo/MP_0013403 abnormal circulating lactate level http://purl.obolibrary.org/obo/MP_0009642 abnormal blood homeostasis any anomaly of the amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase http://purl.obolibrary.org/obo/MP_0013404 decreased circulating lactate level http://purl.obolibrary.org/obo/MP_0013403 abnormal circulating lactate level reduced amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase http://purl.obolibrary.org/obo/MP_0013405 increased circulating lactate level http://purl.obolibrary.org/obo/MP_0013403 abnormal circulating lactate level greater amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase http://purl.obolibrary.org/obo/MP_0013406 abnormal epidermal immune compartment http://purl.obolibrary.org/obo/MP_0001216 abnormal epidermal layer morphology any anomaly in the constitution or organization of the immune cells residing in the skin epidermal layer http://purl.obolibrary.org/obo/MP_0013407 abnormal dendritic epidermal T cell morphology http://purl.obolibrary.org/obo/MP_0013406 abnormal epidermal immune compartment any structural anomaly of T cells with dendritic appearance residing in the skin epidermis, usually expressing a canonical gamma-delta T cell receptor and is involved in the regulation of wound healing http://purl.obolibrary.org/obo/MP_0013412 increased Langerhans cell number http://purl.obolibrary.org/obo/MP_0013411 abnormal Langerhans cell number increase in the number of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus http://purl.obolibrary.org/obo/MP_0013413 abnormal myeloid cell number in bone marrow http://purl.obolibrary.org/obo/MP_0011180 abnormal hematopoietic cell number any anomaly in the number of CD45+ CD11b+ GR1- myeloid cells in the bone marrow http://purl.obolibrary.org/obo/MP_0013414 decreased myeloid cell number in bone marrow http://purl.obolibrary.org/obo/MP_0013413 abnormal myeloid cell number in bone marrow reduction in the number of CD45+ CD11b+ GR1- myeloid cells in the bone marrow http://purl.obolibrary.org/obo/MP_0013415 increased myeloid cell number in bone marrow http://purl.obolibrary.org/obo/MP_0013413 abnormal myeloid cell number in bone marrow increase in the number of CD45+ CD11b+ GR1- myeloid cells in the bone marrow http://purl.obolibrary.org/obo/MP_0013416 abnormal memory-marker gamma-delta T cell number http://purl.obolibrary.org/obo/MP_0008345 abnormal gamma-delta T cell number anomaly in the number of memory-marker gamma-delta T cells with a CD44+ CD62L- phenotype http://purl.obolibrary.org/obo/MP_0013417 decreased memory-marker gamma-delta T cell number http://purl.obolibrary.org/obo/MP_0013416 abnormal memory-marker gamma-delta T cell number reduction in the number of memory-marker gamma-delta T cells with a CD44+ CD62L- phenotype http://purl.obolibrary.org/obo/MP_0013418 increased memory-marker gamma-delta T cell number http://purl.obolibrary.org/obo/MP_0013416 abnormal memory-marker gamma-delta T cell number increase in the number of memory-marker gamma-delta T cells with a CD44+ CD62L- phenotype http://purl.obolibrary.org/obo/MP_0013419 abnormal CD5-positive gamma-delta T cell number http://purl.obolibrary.org/obo/MP_0008345 abnormal gamma-delta T cell number anomaly in the number of CD5+ gamma-delta T cells http://purl.obolibrary.org/obo/MP_0013420 decreased CD5-positive gamma-delta T cell number http://purl.obolibrary.org/obo/MP_0013419 abnormal CD5-positive gamma-delta T cell number reduction in the number of CD5+ gamma-delta T cells http://purl.obolibrary.org/obo/MP_0013421 increased CD5-positive gamma-delta T cell number http://purl.obolibrary.org/obo/MP_0013419 abnormal CD5-positive gamma-delta T cell number increase in the number of CD5+ gamma-delta T cells http://purl.obolibrary.org/obo/MP_0013422 abnormal KLRG1-positive gamma-delta T cell number http://purl.obolibrary.org/obo/MP_0008345 abnormal gamma-delta T cell number anomaly in the number of gamma-delta T cells positive for KLRG1, a marker associated with activation http://purl.obolibrary.org/obo/MP_0013423 decreased KLRG1-positive gamma-delta T cell number http://purl.obolibrary.org/obo/MP_0013422 abnormal KLRG1-positive gamma-delta T cell number reduction in the number of gamma-delta T cells positive for KLRG1, a marker associated with activation http://purl.obolibrary.org/obo/MP_0013424 increased KLRG1-positive gamma-delta T cell number http://purl.obolibrary.org/obo/MP_0013422 abnormal KLRG1-positive gamma-delta T cell number increase in the number of gamma-delta T cells positive for KLRG1, a marker associated with activation http://purl.obolibrary.org/obo/MP_0013425 abnormal memory-marker NK cell number http://purl.obolibrary.org/obo/MP_0008043 abnormal NK cell number anomaly in the number of memory-marker NK cells with a CD44+ CD62L- phenotype http://purl.obolibrary.org/obo/MP_0013426 decreased memory-marker NK cell number http://purl.obolibrary.org/obo/MP_0013425 abnormal memory-marker NK cell number reduction in the number of memory-marker NK cells with a CD44+ CD62L- phenotype http://purl.obolibrary.org/obo/MP_0013427 increased memory-marker NK cell number http://purl.obolibrary.org/obo/MP_0013425 abnormal memory-marker NK cell number increase in the number of memory-marker NK cells with a CD44+ CD62L- phenotype http://purl.obolibrary.org/obo/MP_0013428 abnormal memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number http://purl.obolibrary.org/obo/MP_0012773 abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number anomaly in the number of the CD4+, CD25+ alpha-beta regulatory T cells with a CD44+ CD62L- memory phenotype http://purl.obolibrary.org/obo/MP_0013429 decreased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number http://purl.obolibrary.org/obo/MP_0013428 abnormal memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number reduction in the number of the CD4+, CD25+ alpha-beta regulatory T cells with a CD44+ CD62L- memory phenotype http://purl.obolibrary.org/obo/MP_0013430 increased memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number http://purl.obolibrary.org/obo/MP_0013428 abnormal memory CD4-positive, CD25-positive, alpha-beta regulatory T cell number increase in the number of the CD4+, CD25+ alpha-beta regulatory T cells with a CD44+ CD62L- memory phenotype http://purl.obolibrary.org/obo/MP_0013431 abnormal KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number http://purl.obolibrary.org/obo/MP_0012773 abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell number anomaly in the number of KLRG1+ CD4+, CD25+, alpha-beta regulatory T cell number positive for KLRG1, a marker associated with activation http://purl.obolibrary.org/obo/MP_0013432 decreased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number http://purl.obolibrary.org/obo/MP_0013431 abnormal KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number reduction in the number of KLRG1+ CD4+, CD25+, alpha-beta regulatory T cell number positive for KLRG1, a marker associated with activation http://purl.obolibrary.org/obo/MP_0013433 increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number http://purl.obolibrary.org/obo/MP_0013431 abnormal KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number increase in the number of KLRG1+ CD4+, CD25+, alpha-beta regulatory T cell number positive for KLRG1, a marker associated with activation http://purl.obolibrary.org/obo/MP_0013434 abnormal CD8-positive, naive alpha-beta T cell number http://purl.obolibrary.org/obo/MP_0008077 abnormal CD8-positive, alpha-beta T cell number anomaly in the number of the naïve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype http://purl.obolibrary.org/obo/MP_0013435 decreased CD8-positive, naive alpha-beta T cell number http://purl.obolibrary.org/obo/MP_0013434 abnormal CD8-positive, naive alpha-beta T cell number reduction in the number of the naïve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype http://purl.obolibrary.org/obo/MP_0013436 increased CD8-positive, naive alpha-beta T cell number http://purl.obolibrary.org/obo/MP_0013434 abnormal CD8-positive, naive alpha-beta T cell number increase in the number of the naïve regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions with a CD44-low CD62L+ phenotype http://purl.obolibrary.org/obo/MP_0013437 decreased plant sterol level http://purl.obolibrary.org/obo/MP_0010076 abnormal plant sterol level decreased amount of plant sterols often as a result of hyperabsorbtion of phytosterols and decreased biliary excretion of dietary sterols http://purl.obolibrary.org/obo/MP_0013438 dysmyelination http://purl.obolibrary.org/obo/MP_0000920 abnormal myelination reduced amount of myelin present in the form of a myelin sheath surrounding an axon due to defects in the synthesis and formation of myelin http://purl.obolibrary.org/obo/MP_0013439 abnormal Harderian gland development http://purl.obolibrary.org/obo/MP_0005248 abnormal Harderian gland morphology aberrant formation or incomplete differentiation of the sebaceous gland located behind the eyeball that excretes fluid that facilitates movement of the nictitating membrane; in rodents, the Harderian gland originates from the nasal part of the conjunctival epithelium at E16 and forms a branched structure behind the eyeball; in contrast to the acinar morphology of the lacrimal gland, the Harderian gland has a tubulo-alveolar organization and is composed exclusively of one type of secretory cell; in primates, the HG is either absent or vestigial http://purl.obolibrary.org/obo/MP_0013440 abnormal exorbital lacrimal gland morphology http://purl.obolibrary.org/obo/MP_0001346 abnormal lacrimal gland morphology any structural anomaly of the large exorbital (extra-orbital) lacrimal glands that are located subcutaneously at the anteroventral base of the ear adjacent to the parotid gland http://purl.obolibrary.org/obo/MP_0013441 abnormal intraorbital lacrimal gland morphology http://purl.obolibrary.org/obo/MP_0001346 abnormal lacrimal gland morphology any structural anomaly of the small intra-orbital lacrimal glands that are located superficially at the lateral canthus, where both the lacrimal gland and Harderian gland ducts open http://purl.obolibrary.org/obo/MP_0013442 abnormal Harderian gland size http://purl.obolibrary.org/obo/MP_0005248 abnormal Harderian gland morphology anomaly in the average size of the sebaceous gland located behind the eyeball that excretes fluid that facilitates movement of the nictitating membrane http://purl.obolibrary.org/obo/MP_0013443 Harderian gland hyperplasia http://purl.obolibrary.org/obo/MP_0013446 enlarged Harderian gland overdevelopment or increased size, usually due to an increased number of cells, of the sebaceous gland that is located behind the eyeball and excretes fluid that facilitates movement of the nictitating membrane http://purl.obolibrary.org/obo/MP_0013444 Harderian gland hypoplasia http://purl.obolibrary.org/obo/MP_0013448 small Harderian gland underdevelopment or reduced size, usually due to a decreased number of cells, of the sebaceous gland that is located behind the eyeball and excretes fluid that facilitates movement of the nictitating membrane http://purl.obolibrary.org/obo/MP_0013445 Harderian gland atrophy http://purl.obolibrary.org/obo/MP_0013448 small Harderian gland acquired diminution of the size of the sebaceous gland that is located behind the eyeball and excretes fluid that facilitates movement of the nictitating membrane, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0013446 enlarged Harderian gland http://purl.obolibrary.org/obo/MP_0013442 abnormal Harderian gland size increased size of the sebaceous gland that is located behind the eyeball and excretes fluid that facilitates movement of the nictitating membrane http://purl.obolibrary.org/obo/MP_0013447 Harderian gland hypertrophy http://purl.obolibrary.org/obo/MP_0013446 enlarged Harderian gland increase in the bulk size, due to cell enlargement, of the sebaceous gland that is located behind the eyeball and excretes fluid that facilitates movement of the nictitating membrane http://purl.obolibrary.org/obo/MP_0013448 small Harderian gland http://purl.obolibrary.org/obo/MP_0013442 abnormal Harderian gland size decreased size of the sebaceous gland that is located behind the eyeball and excretes fluid that facilitates movement of the nictitating membrane http://purl.obolibrary.org/obo/MP_0013449 abnormal lacrimal lake morphology http://purl.obolibrary.org/obo/MP_0008968 abnormal lacrimal apparatus morphology any structural anomaly of the small cistern-like area of the conjunctiva at the medial angle of the eye, in which the tears collect after bathing the front surface of the eyeball and the conjunctival sac http://purl.obolibrary.org/obo/MP_0013451 nasolacrimal duct obstruction http://purl.obolibrary.org/obo/MP_0013450 abnormal lacrimal apparatus physiology any impediment or blockage of the paired channels leading from the lacrimal sacs to the inferior meatus of the nose, through which tears are conducted through the nasal cavity; may be either congenital or acquired; obstruction of the nasolacrimal duct leads to the excess overflow of tears called epiphora http://purl.obolibrary.org/obo/MP_0013452 increased lacrimal gland apoptosis http://purl.obolibrary.org/obo/MP_0001348 abnormal lacrimal gland physiology increase in the number of cells of the lacrimal gland undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0013453 enlarged lacrimal gland http://purl.obolibrary.org/obo/MP_0001346 abnormal lacrimal gland morphology increased size of any of the paired glands that secrete the aqueous layer of the tear film http://purl.obolibrary.org/obo/MP_0013454 lacrimal gland hypertrophy http://purl.obolibrary.org/obo/MP_0013453 enlarged lacrimal gland increase in the bulk size of any of the paired glands that secrete the aqueous layer of the tear film due to cell enlargement http://purl.obolibrary.org/obo/MP_0013455 lacrimal gland atrophy http://purl.obolibrary.org/obo/MP_0001346 abnormal lacrimal gland morphology acquired diminution of the size of any of the paired glands that secrete the aqueous layer of the tear film, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes http://purl.obolibrary.org/obo/MP_0013456 abnormal eccrine gland number http://purl.obolibrary.org/obo/MP_0000675 abnormal eccrine gland morphology aberration in the number of the coiled tubular glands normally situated on the digits and footpads of the paws of rodents, and both in the histologically thick skin of the palmar and plantar surfaces and in the thin skin that covers most of the rest of the body in humans; in mice these are the only sweat glands present http://purl.obolibrary.org/obo/MP_0013457 increased eccrine gland number http://purl.obolibrary.org/obo/MP_0013456 abnormal eccrine gland number greater than normal numbers of the coiled tubular glands situated on the digits and footpads of the paws of rodents, and both in the histologically thick skin of the palmar and plantar surfaces and in the thin skin that covers most of the rest of the body in humans; in mice these are the only sweat glands present http://purl.obolibrary.org/obo/MP_0013458 decreased eccrine gland number http://purl.obolibrary.org/obo/MP_0013456 abnormal eccrine gland number fewer than normal numbers of the coiled tubular glands situated on the digits and footpads of the paws of rodents, and both in the histologically thick skin of the palmar and plantar surfaces and in the thin skin that covers most of the rest of the body in humans; in mice these are the only sweat glands present http://purl.obolibrary.org/obo/MP_0013459 perioral dermatitis http://purl.obolibrary.org/obo/MP_0001194 dermatitis an inflammatory skin condition characterized by multiple small papules, pustules and vesicles localized to the perioral skin (around the mouth), perinasal or nasolabial folds (around the nostrils), or periocular area (around the eyes) http://purl.obolibrary.org/obo/MP_0013460 periocular dermatitis http://purl.obolibrary.org/obo/MP_0013459 perioral dermatitis inflammation of the skin on the eyelids and around the eyes; a variant of perioral dermatitis http://purl.obolibrary.org/obo/MP_0013461 abnormal conjunctiva fornix morphology http://purl.obolibrary.org/obo/MP_0001310 abnormal conjunctiva morphology any structural anomaly of the space formed by the junction of the bulbar and palpebral portions of the conjunctiva, that of the upper lid being the superior conjunctival fornix (fornix conjunctivae superior) and that of the lower lid, the inferior conjunctival fornix (fornix conjunctivae inferior); the fornix is loose and flexible, allowing the free movement of the lids and eyeball http://purl.obolibrary.org/obo/MP_0013462 abnormal conjunctiva goblet cell number http://purl.obolibrary.org/obo/MP_0012164 abnormal conjunctiva goblet cell morphology aberration in the number of the mucin-secreting cells found on the conjunctival epithelium; changes in goblet cell numbers are associated with alterations in tear mucin level http://purl.obolibrary.org/obo/MP_0013463 increased conjunctiva goblet cell number http://purl.obolibrary.org/obo/MP_0013462 abnormal conjunctiva goblet cell number greater than normal numbers of the mucin-secreting cells found on the conjunctival epithelium http://purl.obolibrary.org/obo/MP_0013464 decreased conjunctiva goblet cell number http://purl.obolibrary.org/obo/MP_0013462 abnormal conjunctiva goblet cell number fewer than normal numbers of the mucin-secreting cells found on the conjunctival epithelium; goblet cell loss has been reported in several inflammatory diseases of the ocular surface, including Stevens-Johnson syndrome, ocular mucous membrane pemphigoid, alkali burn, neutrophilic keratitis, graft-versus-host-disease, and Sjogrens's syndrome http://purl.obolibrary.org/obo/MP_0013465 conjunctiva goblet cell differentiation http://purl.obolibrary.org/obo/MP_0012164 abnormal conjunctiva goblet cell morphology abnormal or arrested formation of the mucin-secreting cells of the conjunctival epithelium from conjunctival precursor/stem cells; in mice, mucin-rich goblet cells normally emerge from the conjunctival epithelium around P7-P9, increase in number and form goblet cell clusters between the second and third week of postnatal development http://purl.obolibrary.org/obo/MP_0013466 keratoconjunctivitis sicca http://purl.obolibrary.org/obo/MP_0006194 keratoconjunctivitis inflammation of the cornea and conjuctiva caused by eye dryness which, in turn, is caused by either decreased tear production or increased tear film evaporation http://purl.obolibrary.org/obo/MP_0013467 diaphragmitis http://purl.obolibrary.org/obo/MP_0002106 abnormal muscle physiology inflammation of the diaphragm http://purl.obolibrary.org/obo/MP_0013468 chromodacryorrhea http://purl.obolibrary.org/obo/MP_0020218 abnormal tear production shedding of red or blood-stained tears due to continuous or excessive secretion of porphyrin from the Harderian gland; as these secretions overflow from the eye and drain through the nasal passages to exit the nares dark rust-colored staining, or crust, can be seen around the eyes and nostrils; these secretions may be transferred to the paws and muzzle during grooming; red tears may be associated with nutritional deficiencies, chronic physiological stress, chronic light exposure, or dacryoadenitis http://purl.obolibrary.org/obo/MP_0013469 abnormal lacrimal gland bud morphology http://purl.obolibrary.org/obo/MP_0013331 abnormal lacrimal gland development any structural anomaly of the single bud-like invagination of the conjunctival fornix epithelium at the temporal aspect of the eye that signals lacrimal gland formation; in mouse, the primary bud arises around E13.5 and extends caudally into the surrounding neural-crest derived periocular mesenchyme; between E15.5 and E16.5 the bud undergoes branching morphogenesis, forming both a major extra-orbital lobe and a minor intraorbital lobe http://purl.obolibrary.org/obo/MP_0013470 absent lacrimal gland bud http://purl.obolibrary.org/obo/MP_0013469 abnormal lacrimal gland bud morphology absence of the single bud-like invagination of the conjunctival fornix epithelium at the temporal aspect of the eye that signals lacrimal gland formation; in mouse, the primary bud arises around E13.5 and extends caudally into the surrounding neural-crest derived periocular mesenchyme at E14.5 http://purl.obolibrary.org/obo/MP_0013471 small lacrimal gland bud http://purl.obolibrary.org/obo/MP_0013469 abnormal lacrimal gland bud morphology reduced size of the single bud-like invagination of the conjunctival fornix epithelium at the temporal aspect of the eye that signals lacrimal gland formation; in mouse, the primary bud arises around E13.5 and extends caudally into the surrounding neural-crest derived periocular mesenchyme at E14.5; following elongation, the bud invades the mesenchymal sac at E16.5 and begins a period of rapid growth and branching to form prospective lobular structures: the intra- and ex-orbital lobes http://purl.obolibrary.org/obo/MP_0013472 abnormal lacrimal gland bud elongation http://purl.obolibrary.org/obo/MP_0013331 abnormal lacrimal gland development anomaly in the process by which the primary lacrimal bud extends caudally into the surrounding neural-crest derived periocular mesenchyme; in mice, the primary bud formed at E13.5 elongates at E14.5; following elongation, the bud invades the mesenchymal sac at E16.5 and begins a period of rapid growth and branching to form prospective lobular structures: the intra- and ex-orbital lobes http://purl.obolibrary.org/obo/MP_0013473 ectopic lacrimal gland bud http://purl.obolibrary.org/obo/MP_0013469 abnormal lacrimal gland bud morphology lacrimal gland bud(s) are located other than in the normal or expected position http://purl.obolibrary.org/obo/MP_0013474 abnormal lacrimal gland branching morphogenesis http://purl.obolibrary.org/obo/MP_0013331 abnormal lacrimal gland development anomaly of the lacrimal gland bud to repeatedly divide into lobules during development of the lacrimal gland; in mouse, the primary bud arises around E13.5 and extends caudally into the surrounding neural-crest derived periocular mesenchyme; branching is initiated between E15.5 and E16.5 from the tip of the lacrimal bud; by E18.5, the gland consists of an extensively branched exorbital lobe and a small intraocular lobe derived from a single branch of the proximal duct; branching and differentiation of lacrimal glands is complete by around eyelid opening http://purl.obolibrary.org/obo/MP_0013475 delayed reproductive senescence http://purl.obolibrary.org/obo/MP_0002161 abnormal fertility/fecundity loss of reproductive capacity occurring at a later than expected age; often accompanied by inability to carry offspring to term http://purl.obolibrary.org/obo/MP_0013476 abnormal Harderian gland porphyrin secretion http://purl.obolibrary.org/obo/MP_0003859 abnormal Harderian gland physiology anomaly in the production and/or release of porphyrin(s), the pigment(s) responsible for the red discoloration of ocular and/or nasal discharges in rodents; in rats, protoporhyrin IX accounts for most of the porphyrin produced and stored in the Harderian gland; in some rodents the concentration of porphyrins in the Harderian glands varies according to gender and species, and tends to be higher in females than in males http://purl.obolibrary.org/obo/MP_0013477 abnormal cornea limbus morphology http://purl.obolibrary.org/obo/MP_0002092 abnormal eye morphology any structural anomaly of the edge of the cornea where it joins the sclera; the limbus is a common site for the occurrence of corneal epithelial neoplasm http://purl.obolibrary.org/obo/MP_0013478 corneal limbitis http://purl.obolibrary.org/obo/MP_0001851 eye inflammation inflammation of the corneal limbus http://purl.obolibrary.org/obo/MP_0013479 scleritis http://purl.obolibrary.org/obo/MP_0001851 eye inflammation inflammation of the sclera, the tough white outer coat of the eyeball; may impair vision and occur in association with systemic collagen diseases such as rheumatoid arthritis, Wegener's granulomatosis and, less often, lupus http://purl.obolibrary.org/obo/MP_0013480 cyclitis http://purl.obolibrary.org/obo/MP_0001851 eye inflammation inflammation of the ciliary body of the eye http://purl.obolibrary.org/obo/MP_0020000 abnormal response to antigen http://purl.obolibrary.org/obo/MP_0001790 abnormal immune system physiology anomaly in the immune response after exposure to an antigen http://purl.obolibrary.org/obo/MP_0020001 decreased response to antigen http://purl.obolibrary.org/obo/MP_0020000 abnormal response to antigen decreased or weak immune response after exposure to an antigen http://purl.obolibrary.org/obo/MP_0020002 increased response to antigen http://purl.obolibrary.org/obo/MP_0020000 abnormal response to antigen increased immune response after exposure to an antigen http://purl.obolibrary.org/obo/MP_0020003 abnormal sulfolipid level http://purl.obolibrary.org/obo/MP_0001547 abnormal lipid level an anomaly in the concentration of lipids that possess a sulfur-containing functional group http://purl.obolibrary.org/obo/MP_0020005 decreased sulfoglycosphingolipid level http://purl.obolibrary.org/obo/MP_0012229 abnormal sulfoglycosphingolipid level decreased concentration of the sulfolipids that contribute to myelin function and stability http://purl.obolibrary.org/obo/MP_0020006 increased sulfoglycosphingolipid level http://purl.obolibrary.org/obo/MP_0012229 abnormal sulfoglycosphingolipid level increased concentration of the sulfolipids that contribute to myelin function and stability http://purl.obolibrary.org/obo/MP_0020007 decreased brain sulfoglycosphingolipid level http://purl.obolibrary.org/obo/MP_0020005 decreased sulfoglycosphingolipid level decreased brain concentration of the sulfolipids that contribute to myelin function and stability http://purl.obolibrary.org/obo/MP_0020008 increased brain sulfoglycosphingolipid level http://purl.obolibrary.org/obo/MP_0020006 increased sulfoglycosphingolipid level increased brain concentration of the sulfolipids that contribute to myelin function and stability http://purl.obolibrary.org/obo/MP_0020009 abnormal mineral bone density of femur http://purl.obolibrary.org/obo/MP_0010119 abnormal bone mineral density anomaly in the amount of mineral per square centimeter of bone (usually g/cm2) in the long bone of the thigh http://purl.obolibrary.org/obo/MP_0020010 decreased bone mineral density of femur http://purl.obolibrary.org/obo/MP_0000063 decreased bone mineral density reduction in the amount of mineral per square centimeter of bone (usually g/cm2) in the long bone of the thigh http://purl.obolibrary.org/obo/MP_0020011 increased bone mineral density of femur http://purl.obolibrary.org/obo/MP_0000062 increased bone mineral density elevation in the amount of mineral per square centimeter of bone (usually g/cm2) in the long bone of the thigh http://purl.obolibrary.org/obo/MP_0020012 abnormal arylsulphatase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: a phenol sulfate + H2O = a phenol + sulfate. http://purl.obolibrary.org/obo/MP_0020013 decreased arylsulphatase activity http://purl.obolibrary.org/obo/MP_0020012 abnormal arylsulphatase activity decreased ability to catalyze the reaction: a phenol sulfate + H2O = a phenol + sulfate http://purl.obolibrary.org/obo/MP_0020014 increased arylsulphatase activity http://purl.obolibrary.org/obo/MP_0020012 abnormal arylsulphatase activity increased ability to catalyze the reaction: a phenol sulfate + H2O = a phenol + sulfate http://purl.obolibrary.org/obo/MP_0020015 abnormal aldehyde dehydrogenase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the oxidation (dehydrogenation) of aldehydes. http://purl.obolibrary.org/obo/MP_0020016 decreased aldehyde dehydrogenase activity http://purl.obolibrary.org/obo/MP_0020015 abnormal aldehyde dehydrogenase activity increased ability to catalyze the oxidation (dehydrogenation) of aldehydes. http://purl.obolibrary.org/obo/MP_0020017 increased aldehyde dehydrogenase activity http://purl.obolibrary.org/obo/MP_0020015 abnormal aldehyde dehydrogenase activity decreased ability to catalyze the oxidation (dehydrogenation) of aldehydes. http://purl.obolibrary.org/obo/MP_0020018 abnormal phenylalanine decarboxylase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: L-phenylalanine = phenylethylamine + CO2. http://purl.obolibrary.org/obo/MP_0020019 decreased phenylalanine decarboxylase activity http://purl.obolibrary.org/obo/MP_0020018 abnormal phenylalanine decarboxylase activity decreased ability to catalyze the reaction: L-phenylalanine = phenylethylamine + CO2 http://purl.obolibrary.org/obo/MP_0020020 increased phenylalanine decarboxylase activity http://purl.obolibrary.org/obo/MP_0020018 abnormal phenylalanine decarboxylase activity increased ability to catalyze the reaction: L-phenylalanine = phenylethylamine + CO2 http://purl.obolibrary.org/obo/MP_0020021 abnormal delta-aminolaevulinate dehydratase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen. http://purl.obolibrary.org/obo/MP_0020022 decreased delta-aminolaevulinate dehydratase activity http://purl.obolibrary.org/obo/MP_0020021 abnormal delta-aminolaevulinate dehydratase activity decreased ability to catalyze the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen. http://purl.obolibrary.org/obo/MP_0020023 decreased hepatic delta-aminolaevulinate dehydratase activity http://purl.obolibrary.org/obo/MP_0020022 decreased delta-aminolaevulinate dehydratase activity decreased ability to catalyze the reaction in the liver: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen. http://purl.obolibrary.org/obo/MP_0020024 increased delta-aminolaevulinate dehydratase activity http://purl.obolibrary.org/obo/MP_0020021 abnormal delta-aminolaevulinate dehydratase activity increased ability to catalyze the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen. http://purl.obolibrary.org/obo/MP_0020025 increased hepatic delta-aminolaevulinate dehydratase activity http://purl.obolibrary.org/obo/MP_0020024 increased delta-aminolaevulinate dehydratase activity increased ability to catalyze the reaction in the liver: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen. http://purl.obolibrary.org/obo/MP_0020026 abnormal aldehyde oxidase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide http://purl.obolibrary.org/obo/MP_0020027 decreased aldehyde oxidase activity http://purl.obolibrary.org/obo/MP_0020026 abnormal aldehyde oxidase activity decreased ability to catalyze the reaction:an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide http://purl.obolibrary.org/obo/MP_0020028 increased aldehyde oxidase activity http://purl.obolibrary.org/obo/MP_0020026 abnormal aldehyde oxidase activity increased ability to catalyze the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide http://purl.obolibrary.org/obo/MP_0020029 abnormal cholinesterase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity aberrant activity of the enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid http://purl.obolibrary.org/obo/MP_0020030 abnormal circulating cholinesterase activity http://purl.obolibrary.org/obo/MP_0020029 abnormal cholinesterase activity aberrant activity of the blood of the enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid http://purl.obolibrary.org/obo/MP_0020031 decreased circulating cholinesterase activity http://purl.obolibrary.org/obo/MP_0020034 decreased cholinesterase activity decreased activity of the blood of the enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid http://purl.obolibrary.org/obo/MP_0020032 increased circulating cholinesterase activity http://purl.obolibrary.org/obo/MP_0020033 increased cholinesterase activity increased activity of the blood of the enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid http://purl.obolibrary.org/obo/MP_0020033 increased cholinesterase activity http://purl.obolibrary.org/obo/MP_0020029 abnormal cholinesterase activity increased activity of the enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid http://purl.obolibrary.org/obo/MP_0020034 decreased cholinesterase activity http://purl.obolibrary.org/obo/MP_0020029 abnormal cholinesterase activity decreased activity of the enzymes that catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid http://purl.obolibrary.org/obo/MP_0020035 abnormal coumarin hydroxylase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+ http://purl.obolibrary.org/obo/MP_0020036 decreased coumarin hydroxylase activity http://purl.obolibrary.org/obo/MP_0020035 abnormal coumarin hydroxylase activity decreased ability to catalyze the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+ http://purl.obolibrary.org/obo/MP_0020037 increased coumarin hydroxylase activity http://purl.obolibrary.org/obo/MP_0020035 abnormal coumarin hydroxylase activity increased ability to catalyze the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+ http://purl.obolibrary.org/obo/MP_0020041 resistant to pulmonary hyaline membrane formation http://purl.obolibrary.org/obo/MP_0002133 abnormal respiratory system physiology decreased likelihood of the presence of an eosinophilic hyaline (glass-like) material composed of fibrin, proteinaceous exudate and cellular debris, and lining or filling the alveoli, alveolar ducts and bronchioles http://purl.obolibrary.org/obo/MP_0020042 abnormal glucose-6-phosphate dehydrogenase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+ http://purl.obolibrary.org/obo/MP_0020043 decreased glucose-6-phosphate dehydrogenase activity http://purl.obolibrary.org/obo/MP_0020042 abnormal glucose-6-phosphate dehydrogenase activity decreased ability to catalyze the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+ http://purl.obolibrary.org/obo/MP_0020044 increased glucose-6-phosphate dehydrogenase activity http://purl.obolibrary.org/obo/MP_0020042 abnormal glucose-6-phosphate dehydrogenase activity increased ability to catalyze the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+ http://purl.obolibrary.org/obo/MP_0020045 abnormal tyrosine aminotransferase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the transfer of an amino group from L-tyrosine to an acceptor, usually a 2-oxo acid http://purl.obolibrary.org/obo/MP_0020046 decreased tyrosine aminotransferase activity http://purl.obolibrary.org/obo/MP_0020045 abnormal tyrosine aminotransferase activity decreased ability to catalyze the transfer of an amino group from L-tyrosine to an acceptor, usually a 2-oxo acid http://purl.obolibrary.org/obo/MP_0020047 increased tyrosine aminotransferase activity http://purl.obolibrary.org/obo/MP_0020045 abnormal tyrosine aminotransferase activity increased ability to catalyze the transfer of an amino group from L-tyrosine to an acceptor, usually a 2-oxo acid http://purl.obolibrary.org/obo/MP_0020048 abnormal maltase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: alpha-maltose + H2O = 2 alpha-D-glucose http://purl.obolibrary.org/obo/MP_0020049 decreased maltase activity http://purl.obolibrary.org/obo/MP_0020048 abnormal maltase activity decreased ability to catalyze the reaction:alpha-maltose + H2O = 2 alpha-D-glucose http://purl.obolibrary.org/obo/MP_0020050 increased maltase activity http://purl.obolibrary.org/obo/MP_0020048 abnormal maltase activity increased ability to catalyze the reaction:alpha-maltose + H2O = 2 alpha-D-glucose http://purl.obolibrary.org/obo/MP_0020051 abnormal procollagen-proline 4-dioxygenase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2 http://purl.obolibrary.org/obo/MP_0020052 decreased procollagen-proline 4-dioxygenase activity http://purl.obolibrary.org/obo/MP_0020051 abnormal procollagen-proline 4-dioxygenase activity decreased ability to catalyze the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2 http://purl.obolibrary.org/obo/MP_0020053 increased procollagen-proline 4-dioxygenase activity http://purl.obolibrary.org/obo/MP_0020051 abnormal procollagen-proline 4-dioxygenase activity increased ability to catalyze the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2 http://purl.obolibrary.org/obo/MP_0020054 abnormal beta-glucuronidase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate http://purl.obolibrary.org/obo/MP_0020055 abnormal spermatazoal beta-glucuronidase activity http://purl.obolibrary.org/obo/MP_0020054 abnormal beta-glucuronidase activity anomaly in the ability to catalyze the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate in the spermatozoa http://purl.obolibrary.org/obo/MP_0020056 decreased beta-glucuronidase activity http://purl.obolibrary.org/obo/MP_0020054 abnormal beta-glucuronidase activity reduced ability to catalyze the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate http://purl.obolibrary.org/obo/MP_0020057 decreased spermatazoal beta-glucuronidase activity http://purl.obolibrary.org/obo/MP_0020055 abnormal spermatazoal beta-glucuronidase activity reduced ability to catalyze the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate in the spermatozoa http://purl.obolibrary.org/obo/MP_0020058 increased beta-glucuronidase activity http://purl.obolibrary.org/obo/MP_0020054 abnormal beta-glucuronidase activity greater ability to catalyze the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate http://purl.obolibrary.org/obo/MP_0020059 increased spermatazoal beta-glucuronidase activity http://purl.obolibrary.org/obo/MP_0020055 abnormal spermatazoal beta-glucuronidase activity greater ability to catalyze the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate in the spermatozoa http://purl.obolibrary.org/obo/MP_0020060 abnormal hypoxanthine phosphoribosyltransferase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate http://purl.obolibrary.org/obo/MP_0020061 decreased hypoxanthine phosphoribosyltransferase activity http://purl.obolibrary.org/obo/MP_0020060 abnormal hypoxanthine phosphoribosyltransferase activity decreased ability to catalyze the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate http://purl.obolibrary.org/obo/MP_0020062 increased hypoxanthine phosphoribosyltransferase activity http://purl.obolibrary.org/obo/MP_0020060 abnormal hypoxanthine phosphoribosyltransferase activity increased ability to catalyze the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate http://purl.obolibrary.org/obo/MP_0020063 abnormal thiopurine S-methyltransferase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether http://purl.obolibrary.org/obo/MP_0020064 decreased thiopurine S-methyltransferase activity http://purl.obolibrary.org/obo/MP_0020063 abnormal thiopurine S-methyltransferase activity decreased ability to catalyze the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether http://purl.obolibrary.org/obo/MP_0020065 increased thiopurine S-methyltransferase activity http://purl.obolibrary.org/obo/MP_0020063 abnormal thiopurine S-methyltransferase activity increased ability to catalyze the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether http://purl.obolibrary.org/obo/MP_0020066 abnormal neocortex size http://purl.obolibrary.org/obo/MP_0008547 abnormal neocortex morphology deviation from the average range of neocortex size compared to normal http://purl.obolibrary.org/obo/MP_0020067 increased neocortex size http://purl.obolibrary.org/obo/MP_0020066 abnormal neocortex size greater than average size of the neocortex http://purl.obolibrary.org/obo/MP_0020068 increased neocortex volume http://purl.obolibrary.org/obo/MP_0020067 increased neocortex size increase from the average range of neocortex volume compared to normal http://purl.obolibrary.org/obo/MP_0020069 decreased neocortex size http://purl.obolibrary.org/obo/MP_0020066 abnormal neocortex size size reduction or truncation of the neocortex http://purl.obolibrary.org/obo/MP_0020070 decreased neocortex volume http://purl.obolibrary.org/obo/MP_0020069 decreased neocortex size decrease from the average range of neocortex volume compared to normal http://purl.obolibrary.org/obo/MP_0020071 decreased blood catalase activity http://purl.obolibrary.org/obo/MP_0011594 decreased catalase activity reduced ability of the catalase enzyme in the blood to catalyze the reaction: 2 hydrogen peroxide = O2 + 2 H2O http://purl.obolibrary.org/obo/MP_0020072 increased blood catalase activity http://purl.obolibrary.org/obo/MP_0011593 increased catalase activity increased ability of the catalase enzyme in the blood to catalyze the reaction: 2 hydrogen peroxide = O2 + 2 H2O http://purl.obolibrary.org/obo/MP_0020073 abnormal tyrosine 3-monooxygenase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine http://purl.obolibrary.org/obo/MP_0020074 abnormal brain tyrosine 3-monooxygenase activity http://purl.obolibrary.org/obo/MP_0020073 abnormal tyrosine 3-monooxygenase activity anomaly in the ability to catalyze the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine in the brain http://purl.obolibrary.org/obo/MP_0020075 increased tyrosine 3-monooxygenase activity http://purl.obolibrary.org/obo/MP_0020073 abnormal tyrosine 3-monooxygenase activity greater ability to catalyze the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine http://purl.obolibrary.org/obo/MP_0020076 increased brain tyrosine 3-monooxygenase activity http://purl.obolibrary.org/obo/MP_0020075 increased tyrosine 3-monooxygenase activity greater ability to catalyze the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine in the brain http://purl.obolibrary.org/obo/MP_0020077 decreased tyrosine 3-monooxygenase activity http://purl.obolibrary.org/obo/MP_0020073 abnormal tyrosine 3-monooxygenase activity reduction in the ability to catalyze the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine http://purl.obolibrary.org/obo/MP_0020078 decreased brain tyrosine 3-monooxygenase activity http://purl.obolibrary.org/obo/MP_0020077 decreased tyrosine 3-monooxygenase activity reduction in the ability to catalyze the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine in the brain http://purl.obolibrary.org/obo/MP_0020079 increased incidence of epicardial mineralization http://purl.obolibrary.org/obo/MP_0003057 abnormal epicardium morphology increased incidence of mineral deposits in the epicardial tissue http://purl.obolibrary.org/obo/MP_0020081 degenerative myocardium http://purl.obolibrary.org/obo/MP_0004215 abnormal myocardial fiber physiology deterioration or the inflammation of the heart muscle often caused by oxygen deprivation. It generally occurs as a result of obstruction of the blood supply and can trigger a heart attack http://purl.obolibrary.org/obo/MP_0020082 increased hippocampus volume http://purl.obolibrary.org/obo/MP_0008282 enlarged hippocampus deviation from the average range of the hippocampus volume compared to normal http://purl.obolibrary.org/obo/MP_0020083 decreased hippocampus volume http://purl.obolibrary.org/obo/MP_0008283 small hippocampus decrease from the average range of the hippocampus volume compared to normal http://purl.obolibrary.org/obo/MP_0020084 short ears http://purl.obolibrary.org/obo/MP_0002177 abnormal outer ear morphology reduced length of the ears http://purl.obolibrary.org/obo/MP_0020085 long ears http://purl.obolibrary.org/obo/MP_0002177 abnormal outer ear morphology increased length of the ears http://purl.obolibrary.org/obo/MP_0020086 abnormal susceptibility to non-insulin-dependent diabetes http://purl.obolibrary.org/obo/MP_0001764 abnormal homeostasis an anomaly in the likelihood to develop non-insulin-dependent diabetes http://purl.obolibrary.org/obo/MP_0020087 increased susceptibility to non-insulin-dependent diabetes http://purl.obolibrary.org/obo/MP_0020086 abnormal susceptibility to non-insulin-dependent diabetes increased likelihood to develop non-insulin-dependent diabetes http://purl.obolibrary.org/obo/MP_0020088 decreased susceptibility to non-insulin-dependent diabetes http://purl.obolibrary.org/obo/MP_0020086 abnormal susceptibility to non-insulin-dependent diabetes decreased likelihood to develop non-insulin-dependent diabetes http://purl.obolibrary.org/obo/MP_0020089 increased susceptibility to diet-induced non-insulin dependent diabetes http://purl.obolibrary.org/obo/MP_0020087 increased susceptibility to non-insulin-dependent diabetes increased likelihood to develop diet-induced non-insulin-dependent diabetes http://purl.obolibrary.org/obo/MP_0020090 decreased susceptibility to diet-induced non-insulin dependent diabetes http://purl.obolibrary.org/obo/MP_0020088 decreased susceptibility to non-insulin-dependent diabetes decreased likelihood to develop diet-induced non-insulin-dependent diabetes http://purl.obolibrary.org/obo/MP_0020091 abnormal susceptibility to diet-induced non-insulin dependent diabetes http://purl.obolibrary.org/obo/MP_0020086 abnormal susceptibility to non-insulin-dependent diabetes an anomaly in the likelihood to develop diet-induced non-insulin-dependent diabetes http://purl.obolibrary.org/obo/MP_0020092 abnormal susceptibility to aortic cartilaginous metaplasia http://purl.obolibrary.org/obo/MP_0001544 abnormal cardiovascular system physiology an anomaly in the susceptibility to the transformation of cells comprising the aorta epithelium to arterial chondrocytes that express type II collagen, resulting in heterotopic formation of cartilage and may lead to calcification in the aorta http://purl.obolibrary.org/obo/MP_0020093 decreased susceptibility to aortic cartilaginous metaplasia http://purl.obolibrary.org/obo/MP_0020092 abnormal susceptibility to aortic cartilaginous metaplasia decreased susceptibility to the transformation of cells comprising the aorta epithelium to arterial chondrocytes that express type II collagen, resulting in heterotopic formation of cartilage and may lead to calcification in the aorta http://purl.obolibrary.org/obo/MP_0020094 increased susceptibility to aortic cartilaginous metaplasia http://purl.obolibrary.org/obo/MP_0020092 abnormal susceptibility to aortic cartilaginous metaplasia increased susceptibility to the transformation of cells comprising the aorta epithelium to arterial chondrocytes that express type II collagen, resulting in heterotopic formation of cartilage and may lead to calcification in the aorta http://purl.obolibrary.org/obo/MP_0020095 abnormal mean heart rate adaptation http://purl.obolibrary.org/obo/MP_0001544 abnormal cardiovascular system physiology an anomaly in the mean of the physiological adaptations of the organisms heart rate in response to long term endurance training http://purl.obolibrary.org/obo/MP_0020096 high mean heart rate adaptation http://purl.obolibrary.org/obo/MP_0020095 abnormal mean heart rate adaptation higher than normal mean of the physiological adaptations of the organisms heart rate in response to long term endurance training http://purl.obolibrary.org/obo/MP_0020097 low mean heart rate adaptation http://purl.obolibrary.org/obo/MP_0020095 abnormal mean heart rate adaptation lower than normal mean of the physiological adaptations of the organisms heart rate in response to long term endurance training http://purl.obolibrary.org/obo/MP_0020098 abnormal susceptibility to diet-induced aortic fatty streak lesions http://purl.obolibrary.org/obo/MP_0001544 abnormal cardiovascular system physiology an anomaly in the susceptibility to development of diet-induced fatty streak lesions, the earliest lesions seen with athersclerosis in arteries http://purl.obolibrary.org/obo/MP_0020099 increased susceptibility to diet-induced aortic fatty streak lesions http://purl.obolibrary.org/obo/MP_0020098 abnormal susceptibility to diet-induced aortic fatty streak lesions increased susceptibility to development of diet-induced fatty streak lesions, the earliest lesions seen with athersclerosis in arteries http://purl.obolibrary.org/obo/MP_0020100 decreased susceptibility to diet-induced aortic fatty streak lesions http://purl.obolibrary.org/obo/MP_0020098 abnormal susceptibility to diet-induced aortic fatty streak lesions decreased susceptibility to development of diet-induced fatty streak lesions, the earliest lesions seen with athersclerosis in arteries http://purl.obolibrary.org/obo/MP_0020101 abnormal hepatic glucose production http://purl.obolibrary.org/obo/MP_0002078 abnormal glucose homeostasis an anomaly in the production of glucose in the liver http://purl.obolibrary.org/obo/MP_0020102 increased hepatic glucose production http://purl.obolibrary.org/obo/MP_0020101 abnormal hepatic glucose production increased production of glucose in the liver http://purl.obolibrary.org/obo/MP_0020103 decreased hepatic glucose production http://purl.obolibrary.org/obo/MP_0020101 abnormal hepatic glucose production decreased production of glucose in the liver http://purl.obolibrary.org/obo/MP_0020104 abnormal nitrate level http://purl.obolibrary.org/obo/MP_0001765 abnormal ion homeostasis altered level of nitrate ion in fluids and tissues http://purl.obolibrary.org/obo/MP_0020105 increased nitrate level http://purl.obolibrary.org/obo/MP_0020104 abnormal nitrate level increased level of nitrate ion in fluids and tissues http://purl.obolibrary.org/obo/MP_0020106 decreased nitrate level http://purl.obolibrary.org/obo/MP_0020104 abnormal nitrate level decreased level of nitrate ion in fluids and tissues http://purl.obolibrary.org/obo/MP_0020107 abnormal nitrite level http://purl.obolibrary.org/obo/MP_0001765 abnormal ion homeostasis altered level of nitrite ion in fluids and tissues http://purl.obolibrary.org/obo/MP_0020108 increased nitrite level http://purl.obolibrary.org/obo/MP_0020107 abnormal nitrite level increased level of nitrite ion in fluids and tissues http://purl.obolibrary.org/obo/MP_0020109 decreased nitrite level http://purl.obolibrary.org/obo/MP_0020107 abnormal nitrite level decreased level of nitrite ion in fluids and tissues http://purl.obolibrary.org/obo/MP_0020110 increased thromboxane level http://purl.obolibrary.org/obo/MP_0009818 abnormal thromboxane level increased concentrations of thromboxane, a lipid that has a role in clot formation (thrombosis) http://purl.obolibrary.org/obo/MP_0020111 decreased thromboxane level http://purl.obolibrary.org/obo/MP_0009818 abnormal thromboxane level decreased concentrations of thromboxane, a lipid that has a role in clot formation (thrombosis) http://purl.obolibrary.org/obo/MP_0020112 abnormal carcass lipid http://purl.obolibrary.org/obo/MP_0001547 abnormal lipid level any anomaly in the total lipid content on the carcass of an organism http://purl.obolibrary.org/obo/MP_0020113 high carcass lipid http://purl.obolibrary.org/obo/MP_0020112 abnormal carcass lipid increased total lipid content on the carcass of an organism http://purl.obolibrary.org/obo/MP_0020114 low carcass lipid http://purl.obolibrary.org/obo/MP_0020112 abnormal carcass lipid decreased total lipid content on the carcass of an organism http://purl.obolibrary.org/obo/MP_0020115 abnormal sphingosine level http://purl.obolibrary.org/obo/MP_0001547 abnormal lipid level any anomaly in the concentrations of sphingosine, an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid http://purl.obolibrary.org/obo/MP_0020116 increased sphingosine level http://purl.obolibrary.org/obo/MP_0020115 abnormal sphingosine level increased concentrations of sphingosine, an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid http://purl.obolibrary.org/obo/MP_0020117 decreased sphingosine level http://purl.obolibrary.org/obo/MP_0020115 abnormal sphingosine level decreased concentrations of sphingosine, an 18-carbon amino alcohol with an unsaturated hydrocarbon chain, which forms a primary part of sphingolipids, a class of cell membrane lipids that include sphingomyelin, an important phospholipid http://purl.obolibrary.org/obo/MP_0020118 abnormal alcohol dehydrogenase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to catalyze the reaction: a primary alcohol + acceptor = an aldehyde + reduced acceptor http://purl.obolibrary.org/obo/MP_0020119 decreased alcohol dehydrogenase activity http://purl.obolibrary.org/obo/MP_0020118 abnormal alcohol dehydrogenase activity decreased ability to catalyze the reaction: a primary alcohol + acceptor = an aldehyde + reduced acceptor. http://purl.obolibrary.org/obo/MP_0020120 increased alcohol dehydrogenase activity http://purl.obolibrary.org/obo/MP_0020118 abnormal alcohol dehydrogenase activity increased ability to catalyze the reaction: a primary alcohol + acceptor = an aldehyde + reduced acceptor http://purl.obolibrary.org/obo/MP_0020124 abnormal circulating HDL phospholipid level http://purl.obolibrary.org/obo/MP_0006084 abnormal circulating phospholipid level any anomaly in the concentration in the blood of HDL phospholipid http://purl.obolibrary.org/obo/MP_0020125 increased circulating HDL phospholipid level http://purl.obolibrary.org/obo/MP_0020124 abnormal circulating HDL phospholipid level increase in the concentration in the blood of HDL phospholipid http://purl.obolibrary.org/obo/MP_0020126 decreased circulating HDL phospholipid level http://purl.obolibrary.org/obo/MP_0020124 abnormal circulating HDL phospholipid level decrease in the concentration in the blood of HDL phospholipid http://purl.obolibrary.org/obo/MP_0020127 abnormal circulating non-HDL phospholipid level http://purl.obolibrary.org/obo/MP_0006084 abnormal circulating phospholipid level any anomaly in the concentration in the blood of non-HDL phospholipid http://purl.obolibrary.org/obo/MP_0020128 increased circulating non-HDL phospholipid level http://purl.obolibrary.org/obo/MP_0020127 abnormal circulating non-HDL phospholipid level increase in the concentration in the blood of non-HDL phospholipid http://purl.obolibrary.org/obo/MP_0020129 decreased circulating non-HDL phospholipid level http://purl.obolibrary.org/obo/MP_0020127 abnormal circulating non-HDL phospholipid level decrease in the concentration in the blood of non-HDL phospholipid http://purl.obolibrary.org/obo/MP_0020131 abnormal gallbladder volume http://purl.obolibrary.org/obo/MP_0020134 abnormal gallbladder size any anomaly in the amount of space occupied by gallbladder lumen in the body http://purl.obolibrary.org/obo/MP_0020132 increased gallbladder volume http://purl.obolibrary.org/obo/MP_0009342 enlarged gallbladder less than average amount of space occupied by gallbladder in the body http://purl.obolibrary.org/obo/MP_0020133 decreased gallbladder volume http://purl.obolibrary.org/obo/MP_0005675 small gallbladder greater than average amount of space occupied by gallbladder in the body http://purl.obolibrary.org/obo/MP_0020143 abnormal adrenal gland x-zone size http://purl.obolibrary.org/obo/MP_0008296 abnormal x-zone morphology an anomaly in the size of the x-zone compared to the average on the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla http://purl.obolibrary.org/obo/MP_0020144 small adrenal gland x-zone http://purl.obolibrary.org/obo/MP_0020143 abnormal adrenal gland x-zone size reduced size of the x-zone compared to the average on the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla http://purl.obolibrary.org/obo/MP_0020145 enlarged adrenal gland x-zone http://purl.obolibrary.org/obo/MP_0020143 abnormal adrenal gland x-zone size increased size of the x-zone compared to the average on the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla http://purl.obolibrary.org/obo/MP_0020153 abnormal urine albumin level http://purl.obolibrary.org/obo/MP_0006315 abnormal urine protein level anomaly in the amount of albumin in the urine http://purl.obolibrary.org/obo/MP_0020154 impaired humoral immune response http://purl.obolibrary.org/obo/MP_0001800 abnormal humoral immune response impaired response of the immune system that mediates secreted antibodies produced in B cells http://purl.obolibrary.org/obo/MP_0020155 enhanced humoral immune response http://purl.obolibrary.org/obo/MP_0001800 abnormal humoral immune response enhanced response of the immune system that mediates secreted antibodies produced in B cells http://purl.obolibrary.org/obo/MP_0020156 multinucleated pancreatic acinar cells http://purl.obolibrary.org/obo/MP_0009146 abnormal pancreatic acinar cell morphology pancreatic acinar cells contain multiple nuclei http://purl.obolibrary.org/obo/MP_0020162 decreased susceptibility to virus induced diabetes http://purl.obolibrary.org/obo/MP_0002410 decreased susceptibility to viral infection reduced likelihood that an organism will develop diabetes from a viral infection or from components of or toxins produced by a virus http://purl.obolibrary.org/obo/MP_0020163 increased susceptibility to virus induced diabetes http://purl.obolibrary.org/obo/MP_0002418 increased susceptibility to viral infection increased likelihood that an organism will develop diabetes from a viral infection or from components of or toxins produced by a virus http://purl.obolibrary.org/obo/MP_0020168 decreased thyroid gland weight http://purl.obolibrary.org/obo/MP_0002951 small thyroid gland lower than average weight of the thyroid gland http://purl.obolibrary.org/obo/MP_0020169 increased thyroid gland weight http://purl.obolibrary.org/obo/MP_0005355 enlarged thyroid gland higher than average weight of the thyroid gland http://purl.obolibrary.org/obo/MP_0020170 vacuolated thymus epithelium http://purl.obolibrary.org/obo/MP_0009544 abnormal thymus epithelium morphology The presence of clear, sharply defined vacuoles in the thymus epithelium http://purl.obolibrary.org/obo/MP_0020191 abnormal lymphocyte activation involved in immune response http://purl.obolibrary.org/obo/MP_0003945 abnormal lymphocyte physiology An anomaly in the morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response http://purl.obolibrary.org/obo/MP_0020192 decreased lymphocyte activation involved in immune response http://purl.obolibrary.org/obo/MP_0020191 abnormal lymphocyte activation involved in immune response Decreased change in the morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response http://purl.obolibrary.org/obo/MP_0020193 increased lymphocyte activation involved in immune response http://purl.obolibrary.org/obo/MP_0020191 abnormal lymphocyte activation involved in immune response Increased change in the morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response http://purl.obolibrary.org/obo/MP_0020194 abnormal glycosphingolipid level http://purl.obolibrary.org/obo/MP_0001547 abnormal lipid level any anomaly in the concentrations of glycosphingolipids, a subtype of glycolipids containing the amino alcohol sphingosine, in the body http://purl.obolibrary.org/obo/MP_0020197 decreased reticular tumor incidence http://purl.obolibrary.org/obo/MP_0010282 decreased organ/body region tumor incidence less than the expected number of neoplams in the reticulum, usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0020198 decreased mononuclear phagocyte tumor incidence http://purl.obolibrary.org/obo/MP_0020197 decreased reticular tumor incidence less than the expected number of neoplams in mononuclear phagocyte cells, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0020199 increased reticular tumor incidence http://purl.obolibrary.org/obo/MP_0010274 increased organ/body region tumor incidence greater than the expected number of neoplams in the reticulum, usually in the form of a distinct mass, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0020200 increased mononuclear phagocyte tumor incidence http://purl.obolibrary.org/obo/MP_0020199 increased reticular tumor incidence more than the expected number of neoplams in mononuclear phagocyte cells, in a specific population in a given time period http://purl.obolibrary.org/obo/MP_0020206 abnormal heart left atrium weight http://purl.obolibrary.org/obo/MP_0004857 abnormal heart weight anomaly in the average weight of the left atrium compared to the control http://purl.obolibrary.org/obo/MP_0020207 abnormal heart right atrium weight http://purl.obolibrary.org/obo/MP_0004857 abnormal heart weight anomaly in the average weight of the right atrium compared to the control http://purl.obolibrary.org/obo/MP_0020208 abnormal withers http://purl.obolibrary.org/obo/MP_0001253 abnormal body height abnormal height of the ridge between the shoulder blades of a four-legged mammal http://purl.obolibrary.org/obo/MP_0020209 low withers http://purl.obolibrary.org/obo/MP_0020208 abnormal withers low height of the ridge between the shoulder blades of a four-legged mammal http://purl.obolibrary.org/obo/MP_0020210 high withers http://purl.obolibrary.org/obo/MP_0020208 abnormal withers high height of the ridge between the shoulder blades of a four-legged mammal http://purl.obolibrary.org/obo/MP_0020211 slow movement http://purl.obolibrary.org/obo/MP_0003491 abnormal voluntary movement decreased rate or speed of the coordinated movements executed with a purpose http://purl.obolibrary.org/obo/MP_0020212 impaired leukocyte migration http://purl.obolibrary.org/obo/MP_0003156 abnormal leukocyte migration impaired ability of blood leukocytes to move within or between different tissues and organs of the body by binding to high endothelial venules (HEV), then tethering and rolling along the luminal aspects of HEV http://purl.obolibrary.org/obo/MP_0020213 enhanced leukocyte migration http://purl.obolibrary.org/obo/MP_0003156 abnormal leukocyte migration enhanced ability of blood leukocytes to move within or between different tissues and organs of the body by binding to high endothelial venules (HEV), then tethering and rolling along the luminal aspects of HEV http://purl.obolibrary.org/obo/MP_0020214 susceptible to malignant hyperthermia http://purl.obolibrary.org/obo/MP_0011019 abnormal adaptive thermogenesis increased susceptibility to hyperthermia triggered by exposure to certain drugs used for general anesthesia, specifically the volatile anesthetic agents and the neuromuscular blocking agent, succinylcholine http://purl.obolibrary.org/obo/MP_0020215 impaired blood coagulation http://purl.obolibrary.org/obo/MP_0002551 abnormal blood coagulation impaired ability of the blood to clot http://purl.obolibrary.org/obo/MP_0020216 decreased circulating complement protein level http://purl.obolibrary.org/obo/MP_0010215 abnormal circulating complement protein level less than normal levels of the serum proteins that act sequentially to allow for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes http://purl.obolibrary.org/obo/MP_0020217 increased circulating complement protein level http://purl.obolibrary.org/obo/MP_0010215 abnormal circulating complement protein level more than the normal levels of the serum proteins that act sequentially to allow for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes http://purl.obolibrary.org/obo/MP_0020219 increased tear production http://purl.obolibrary.org/obo/MP_0020218 abnormal tear production increased production of the amount of fluid produced in the eye http://purl.obolibrary.org/obo/MP_0020220 decreased tear production http://purl.obolibrary.org/obo/MP_0020218 abnormal tear production decreased production of the amount of fluid produced in the eye http://purl.obolibrary.org/obo/MP_0020221 blanched foot pads http://purl.obolibrary.org/obo/MP_0000574 abnormal foot pad morphology lack of color in the body of fat on the foot http://purl.obolibrary.org/obo/MP_0020222 abnormal alertness http://purl.obolibrary.org/obo/MP_0004924 abnormal behavior anomaly in the level of awareness or attentiveness http://purl.obolibrary.org/obo/MP_0020223 increased alertness http://purl.obolibrary.org/obo/MP_0020222 abnormal alertness increased or heightened awareness or attentiveness http://purl.obolibrary.org/obo/MP_0020224 decreased alertness http://purl.obolibrary.org/obo/MP_0020222 abnormal alertness decreased level of awareness or attentiveness http://purl.obolibrary.org/obo/MP_0020225 bone necrosis http://purl.obolibrary.org/obo/MP_0001533 abnormal skeleton physiology pathological death of cells or a portion of the bone; usually due to irreversible damage http://purl.obolibrary.org/obo/MP_0020226 decreased hemangioma incidence http://purl.obolibrary.org/obo/MP_0010291 increased cardiovascular system tumor incidence fewer than the expected number of a benign tumor characterized by blood-filled spaces lined by benign endothelial cells, occurring in a specific population in a given time period; a cavernous hemangioma is characterized by large endothelial spaces (caverns), and a capillary hemangioma is characterized by small endothelial spaces http://purl.obolibrary.org/obo/MP_0020227 abnormal proline oxidase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity altered ability of proline oxidase to catalyze the reaction: L-proline + O2 + H2O = L-delta1-pyrroline-5-carboxylate + H2O2 http://purl.obolibrary.org/obo/MP_0020228 decreased proline oxidase activity http://purl.obolibrary.org/obo/MP_0020227 abnormal proline oxidase activity decreased ability of proline oxidase to catalyze the reaction: L-proline + O2 + H2O = L-delta1-pyrroline-5-carboxylate + H2O2 http://purl.obolibrary.org/obo/MP_0020229 increased proline oxidase activity http://purl.obolibrary.org/obo/MP_0020227 abnormal proline oxidase activity increased ability of proline oxidase to catalyze the reaction: L-proline + O2 + H2O = L-delta1-pyrroline-5-carboxylate + H2O2 http://purl.obolibrary.org/obo/MP_0020230 subcutaneous adipose tissue degeneration http://purl.obolibrary.org/obo/MP_0011156 abnormal hypodermis fat layer morphology a retrogressive impairment of function or destruction of the adipose tissue layer beneath the skin http://purl.obolibrary.org/obo/MP_0020231 abnormal tyrosine aminotransferase level http://purl.obolibrary.org/obo/MP_0005319 abnormal enzyme/ coenzyme level anomaly in the level of the enzyme present in the liver that catalyzes the conversion of tyrosine to 4-hydroxyphenylpyruvate http://purl.obolibrary.org/obo/MP_0020232 increased tyrosine aminotransferase level http://purl.obolibrary.org/obo/MP_0020231 abnormal tyrosine aminotransferase level increased level of the enzyme present in the liver that catalyzes the conversion of tyrosine to 4-hydroxyphenylpyruvate http://purl.obolibrary.org/obo/MP_0020233 decreased tyrosine aminotransferase level http://purl.obolibrary.org/obo/MP_0020231 abnormal tyrosine aminotransferase level decreased level of the enzyme present in the liver that catalyzes the conversion of tyrosine to 4-hydroxyphenylpyruvate http://purl.obolibrary.org/obo/MP_0020234 decreased basal metabolism http://purl.obolibrary.org/obo/MP_0008961 abnormal basal metabolism decrease in heat production of an organism at the lowest level of cell chemistry in an inactive, awake, and fasting state http://purl.obolibrary.org/obo/MP_0020235 black belted http://purl.obolibrary.org/obo/MP_0002075 abnormal coat/hair pigmentation the appearance of a stripe of black fur around the circumference of the abdomen http://purl.obolibrary.org/obo/MP_0020236 abnormal proline level http://purl.obolibrary.org/obo/MP_0005332 abnormal amino acid level abnormal concentration of proline and/or its metabolic derivatives, derived from the amino acid L-glutamate http://purl.obolibrary.org/obo/MP_0020237 increased proline level http://purl.obolibrary.org/obo/MP_0020236 abnormal proline level higher than normal concentration of proline and its metabolic derivatives, derived from the amino acid L-glutamate http://purl.obolibrary.org/obo/MP_0020238 decreased proline level http://purl.obolibrary.org/obo/MP_0020236 abnormal proline level lower than normal concentration of proline and its metabolic derivatives, derived from the amino acid L-glutamate http://purl.obolibrary.org/obo/MP_0020239 abnormal skeletal muscle cell apoptosis http://purl.obolibrary.org/obo/MP_0002106 abnormal muscle physiology change in the timing or the number of skeletal muscle cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0020240 increased skeletal muscle cell apoptosis http://purl.obolibrary.org/obo/MP_0020239 abnormal skeletal muscle cell apoptosis increase in the number of skeletal muscle cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0020241 decreased skeletal muscle cell apoptosis http://purl.obolibrary.org/obo/MP_0020239 abnormal skeletal muscle cell apoptosis decrease in the number of skeletal muscle cells undergoing programmed cell death http://purl.obolibrary.org/obo/MP_0020242 enlarged paws http://purl.obolibrary.org/obo/MP_0000572 abnormal autopod morphology larger than average size of the feet http://purl.obolibrary.org/obo/MP_0020243 abnormal pyruvate kinase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity anomaly in the ability to transfer of a phosphate group from phosphoenolpyruvate to ADP, yielding one molecule of pyruvate and one molecule of ATP http://purl.obolibrary.org/obo/MP_0020244 increased pyruvate kinase activity http://purl.obolibrary.org/obo/MP_0020243 abnormal pyruvate kinase activity increased ability to transfer of a phosphate group from phosphoenolpyruvate to ADP, yielding one molecule of pyruvate and one molecule of ATP http://purl.obolibrary.org/obo/MP_0020245 decreased pyruvate kinase activity http://purl.obolibrary.org/obo/MP_0020243 abnormal pyruvate kinase activity reduced ability to the transfer of a phosphate group from phosphoenolpyruvate to ADP, yielding one molecule of pyruvate and one molecule of ATP http://purl.obolibrary.org/obo/MP_0020246 abnormal circulating arginase level http://purl.obolibrary.org/obo/MP_0001570 abnormal circulating enzyme level aberrant concentration in the blood of the enzyme that catalyzes the conversion of arginine + H2O to ornithine + urea http://purl.obolibrary.org/obo/MP_0020247 increased circulating arginase level http://purl.obolibrary.org/obo/MP_0020246 abnormal circulating arginase level increased concentration in the blood of the enzyme that catalyzes the conversion of arginine + H2O to ornithine + urea http://purl.obolibrary.org/obo/MP_0020248 decreased circulating arginase level http://purl.obolibrary.org/obo/MP_0020246 abnormal circulating arginase level decreased concentration in the blood of the enzyme that catalyzes the conversion of arginine + H2O to ornithine + urea http://purl.obolibrary.org/obo/MP_0020249 abnormal argininosuccinate synthetase level http://purl.obolibrary.org/obo/MP_0005319 abnormal enzyme/ coenzyme level aberrant concentration of the enzyme that catalyzes the synthesis of argininosuccinate from citrulline and aspartate. http://purl.obolibrary.org/obo/MP_0020250 increased argininosuccinate synthetase level http://purl.obolibrary.org/obo/MP_0020249 abnormal argininosuccinate synthetase level increased concentration of the enzyme that catalyzes the synthesis of argininosuccinate from citrulline and aspartate. http://purl.obolibrary.org/obo/MP_0020251 decreased argininosuccinate synthetase level http://purl.obolibrary.org/obo/MP_0020249 abnormal argininosuccinate synthetase level decreased concentration of the enzyme that catalyzes the synthesis of argininosuccinate from citrulline and aspartate. http://purl.obolibrary.org/obo/MP_0020252 abnormal collagen level http://purl.obolibrary.org/obo/MP_0008469 abnormal protein level abnormal level of the main structural protein of the various connective tissues in animals http://purl.obolibrary.org/obo/MP_0020253 increased collagen level http://purl.obolibrary.org/obo/MP_0020252 abnormal collagen level increased level of the main structural protein of the various connective tissues in animals http://purl.obolibrary.org/obo/MP_0020254 decreased collagen level http://purl.obolibrary.org/obo/MP_0020252 abnormal collagen level decreased level of the main structural protein of the various connective tissues in animals http://purl.obolibrary.org/obo/MP_0020255 absent circulating factor XII protein http://purl.obolibrary.org/obo/MP_0020256 abnormal circulating factor XII level undetectable levels in the blood of the enzyme that is part of the coagulation cascade and activates factor XI and prekallikrein in vitro http://purl.obolibrary.org/obo/MP_0020256 abnormal circulating factor XII level http://purl.obolibrary.org/obo/MP_0001570 abnormal circulating enzyme level aberrant concentration in the blood of the enzyme that is part of the coagulation cascade and activates factor XI and prekallikrein in vitro http://purl.obolibrary.org/obo/MP_0020257 increased circulating factor XII level http://purl.obolibrary.org/obo/MP_0020256 abnormal circulating factor XII level increased concentration in the blood of the enzyme that is part of the coagulation cascade and activates factor XI and prekallikrein in vitro http://purl.obolibrary.org/obo/MP_0020258 decreased circulating factor XII level http://purl.obolibrary.org/obo/MP_0020256 abnormal circulating factor XII level decreased concentration in the blood of the enzyme that is part of the coagulation cascade and activates factor XI and prekallikrein in vitro http://purl.obolibrary.org/obo/MP_0020259 abnormal beta-galactosidase level http://purl.obolibrary.org/obo/MP_0005319 abnormal enzyme/ coenzyme level abnormal level of the hydrolase enzyme that catalyzes the hydrolysis of beta-galactosides into monosaccharides http://purl.obolibrary.org/obo/MP_0020260 absent beta-galactosidase protein http://purl.obolibrary.org/obo/MP_0020259 abnormal beta-galactosidase level undetectable levels of the hydrolase enzyme that catalyzes the hydrolysis of beta-galactosides into monosaccharides http://purl.obolibrary.org/obo/MP_0020261 increased beta-galactosidase level http://purl.obolibrary.org/obo/MP_0020259 abnormal beta-galactosidase level increased level of the hydrolase enzyme that catalyzes the hydrolysis of beta-galactosides into monosaccharides http://purl.obolibrary.org/obo/MP_0020262 decreased beta-galactosidase level http://purl.obolibrary.org/obo/MP_0020259 abnormal beta-galactosidase level decreased level of the hydrolase enzyme that catalyzes the hydrolysis of beta-galactosides into monosaccharides http://purl.obolibrary.org/obo/MP_0020263 abnormal galactosylceramidase level http://purl.obolibrary.org/obo/MP_0005319 abnormal enzyme/ coenzyme level abnormal level of the enzyme that removes galactose from ceramide derivatives (galactocerebrosides). http://purl.obolibrary.org/obo/MP_0020264 increased galactosylceramidase level http://purl.obolibrary.org/obo/MP_0020263 abnormal galactosylceramidase level increased level of the enzyme that removes galactose from ceramide derivatives (galactocerebrosides). http://purl.obolibrary.org/obo/MP_0020265 decreased galactosylceramidase level http://purl.obolibrary.org/obo/MP_0020263 abnormal galactosylceramidase level decreased level of the enzyme that removes galactose from ceramide derivatives (galactocerebrosides). http://purl.obolibrary.org/obo/MP_0020266 absent galactosylceramidase level http://purl.obolibrary.org/obo/MP_0020263 abnormal galactosylceramidase level undetectable level of the enzyme that removes galactose from ceramide derivatives (galactocerebrosides). http://purl.obolibrary.org/obo/MP_0020267 abnormal beta-mannosidase level http://purl.obolibrary.org/obo/MP_0005319 abnormal enzyme/ coenzyme level abnormal level of the enzyme that catalyses the reaction: hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides http://purl.obolibrary.org/obo/MP_0020268 increased beta-mannosidase level http://purl.obolibrary.org/obo/MP_0020267 abnormal beta-mannosidase level increased level of the enzyme that catalyses the reaction: hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides http://purl.obolibrary.org/obo/MP_0020269 decreased beta-mannosidase level http://purl.obolibrary.org/obo/MP_0020267 abnormal beta-mannosidase level decreased level of the enzyme that catalyses the reaction: hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides http://purl.obolibrary.org/obo/MP_0020270 abnormal branched-chain alpha-keto acid dehydrogenase level http://purl.obolibrary.org/obo/MP_0005319 abnormal enzyme/ coenzyme level abnormal level of the enzyme that catalyzes the oxidative decarboxylation of branched, short-chain alpha-ketoacids http://purl.obolibrary.org/obo/MP_0020271 increased branched-chain alpha-keto acid dehydrogenase level http://purl.obolibrary.org/obo/MP_0020270 abnormal branched-chain alpha-keto acid dehydrogenase level increased level of the enzyme that catalyzes the oxidative decarboxylation of branched, short-chain alpha-ketoacids http://purl.obolibrary.org/obo/MP_0020272 decreased branched-chain alpha-keto acid dehydrogenase level http://purl.obolibrary.org/obo/MP_0020270 abnormal branched-chain alpha-keto acid dehydrogenase level decreased level of the enzyme that catalyzes the oxidative decarboxylation of branched, short-chain alpha-ketoacids http://purl.obolibrary.org/obo/MP_0020273 abnormal N-acetylgalactosamine-4-sulfatase level http://purl.obolibrary.org/obo/MP_0005319 abnormal enzyme/ coenzyme level abnormal level of the enzyme that catalyzes the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate http://purl.obolibrary.org/obo/MP_0020274 increased N-acetylgalactosamine-4-sulfatase protein level http://purl.obolibrary.org/obo/MP_0020273 abnormal N-acetylgalactosamine-4-sulfatase level increased level of the enzyme that catalyzes the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate http://purl.obolibrary.org/obo/MP_0020275 decreased N-acetylgalactosamine-4-sulfatase protein level http://purl.obolibrary.org/obo/MP_0020273 abnormal N-acetylgalactosamine-4-sulfatase level decreased level of the enzyme that catalyzes the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate http://purl.obolibrary.org/obo/MP_0020276 abnormal glycogen debranching enzyme level http://purl.obolibrary.org/obo/MP_0005319 abnormal enzyme/ coenzyme level abnormal level of the enzyme that helps facilitate the breakdown of glycogen by mobilize glucose reserves from glycogen deposits in the muscles and liver http://purl.obolibrary.org/obo/MP_0020277 increased glycogen debranching enzyme level http://purl.obolibrary.org/obo/MP_0020276 abnormal glycogen debranching enzyme level increased level of the enzyme that helps facilitate the breakdown of glycogen by mobilize glucose reserves from glycogen deposits in the muscles and liver http://purl.obolibrary.org/obo/MP_0020278 decreased glycogen debranching enzyme level http://purl.obolibrary.org/obo/MP_0020276 abnormal glycogen debranching enzyme level decreased level of the enzyme that helps facilitate the breakdown of glycogen by mobilize glucose reserves from glycogen deposits in the muscles and liver http://purl.obolibrary.org/obo/MP_0020282 abnormal hydroxymethylbilane synthase level http://purl.obolibrary.org/obo/MP_0005319 abnormal enzyme/ coenzyme level abnormal level of the enzyme that catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane while releasing four ammonia molecules http://purl.obolibrary.org/obo/MP_0020283 increased hydroxymethylbilane synthase level http://purl.obolibrary.org/obo/MP_0020282 abnormal hydroxymethylbilane synthase level increased level of the enzyme that catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane while releasing four ammonia molecules http://purl.obolibrary.org/obo/MP_0020284 decreased hydroxymethylbilane synthase level http://purl.obolibrary.org/obo/MP_0020282 abnormal hydroxymethylbilane synthase level decreased level of the enzyme that catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane while releasing four ammonia molecules http://purl.obolibrary.org/obo/MP_0020285 abnormal palmitoyl-(protein) hydrolase level http://purl.obolibrary.org/obo/MP_0005319 abnormal enzyme/ coenzyme level abnomal level of the enzyme that removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation http://purl.obolibrary.org/obo/MP_0020286 increased palmitoyl-(protein) hydrolase level http://purl.obolibrary.org/obo/MP_0020285 abnormal palmitoyl-(protein) hydrolase level increased level fo the enzyme that removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation http://purl.obolibrary.org/obo/MP_0020287 decreased palmitoyl-(protein) hydrolase level http://purl.obolibrary.org/obo/MP_0020285 abnormal palmitoyl-(protein) hydrolase level increased level fo the enzyme that removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation http://purl.obolibrary.org/obo/MP_0020288 supernumerary limbs http://purl.obolibrary.org/obo/MP_0002109 abnormal limb morphology more than the expected number of limbs differentiate during early embryogenesis http://purl.obolibrary.org/obo/MP_0020289 astasia http://purl.obolibrary.org/obo/MP_0003312 abnormal locomotor coordination the inability to stand due to muscular incoordination http://purl.obolibrary.org/obo/MP_0020290 floppy ears http://purl.obolibrary.org/obo/MP_0002177 abnormal outer ear morphology ears that are limp or hanging loosely http://purl.obolibrary.org/obo/MP_0020291 abnormal dystrophin level http://purl.obolibrary.org/obo/MP_0008469 abnormal protein level deviation from the normal level of the cytoplasmic protein that connects the cytoskeleton of a muscle fiber to the surrounding extracellular matrix through the cell membrane http://purl.obolibrary.org/obo/MP_0020292 decreased dystrophin level http://purl.obolibrary.org/obo/MP_0020291 abnormal dystrophin level reduced level of the cytoplasmic protein that connects the cytoskeleton of a muscle fiber to the surrounding extracellular matrix through the cell membrane http://purl.obolibrary.org/obo/MP_0020293 increased dystrophin level http://purl.obolibrary.org/obo/MP_0020291 abnormal dystrophin level greater level of the cytoplasmic protein that connects the cytoskeleton of a muscle fiber to the surrounding extracellular matrix through the cell membrane http://purl.obolibrary.org/obo/MP_0020294 abnormal guanylate cyclase activating protein-2 level http://purl.obolibrary.org/obo/MP_0008469 abnormal protein level abnormal level of the enzyme that accelerates the recovery of rods and cones from excitation by light in response to calcium proteins http://purl.obolibrary.org/obo/MP_0020295 decreased guanylate cyclase activating protein-2 level http://purl.obolibrary.org/obo/MP_0020294 abnormal guanylate cyclase activating protein-2 level decreased level of the enzyme that accelerates the recovery of rods and cones from excitation by light in response to calcium proteins http://purl.obolibrary.org/obo/MP_0020296 increased guanylate cyclase activating protein-2 level http://purl.obolibrary.org/obo/MP_0020294 abnormal guanylate cyclase activating protein-2 level increased level of the enzyme that accelerates the recovery of rods and cones from excitation by light in response to calcium proteins http://purl.obolibrary.org/obo/MP_0020297 abnormal UDP-N-acetylglucosamine-1-phosphotransferase level http://purl.obolibrary.org/obo/MP_0008469 abnormal protein level abnormal level of the enzyme that catalyzes the chemical reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose to UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose http://purl.obolibrary.org/obo/MP_0020298 decreased UDP-N-acetylglucosamine-1-phosphotransferase level http://purl.obolibrary.org/obo/MP_0020297 abnormal UDP-N-acetylglucosamine-1-phosphotransferase level decreased level of the enzyme that catalyzes the chemical reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose to UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose http://purl.obolibrary.org/obo/MP_0020299 increased UDP-N-acetylglucosamine-1-phosphotransferase level http://purl.obolibrary.org/obo/MP_0020297 abnormal UDP-N-acetylglucosamine-1-phosphotransferase level increased level of the enzyme that catalyzes the chemical reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose to UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose http://purl.obolibrary.org/obo/MP_0020300 long tongue http://purl.obolibrary.org/obo/MP_0000762 abnormal tongue morphology increased length of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor http://purl.obolibrary.org/obo/MP_0020301 short tongue http://purl.obolibrary.org/obo/MP_0000762 abnormal tongue morphology decreased length of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor http://purl.obolibrary.org/obo/MP_0020302 large horns http://purl.obolibrary.org/obo/MP_0020304 abnormal horn morphology increased size of the one or more of the hard pointed parts that grows on the head of some animals http://purl.obolibrary.org/obo/MP_0020303 small horns http://purl.obolibrary.org/obo/MP_0020304 abnormal horn morphology decreased size of the one or more of the hard pointed parts that grows on the head of some animals http://purl.obolibrary.org/obo/MP_0020304 abnormal horn morphology http://purl.obolibrary.org/obo/MP_0000432 abnormal head morphology any structural anomaly of the hard pointed parts that grows on the head of some animals http://purl.obolibrary.org/obo/MP_0020305 abnormal horn pigmentation http://purl.obolibrary.org/obo/MP_0020304 abnormal horn morphology irregular or unusual pigmentation of the hard pointed parts that grows on the head of some animals http://purl.obolibrary.org/obo/MP_0020306 absent horns http://purl.obolibrary.org/obo/MP_0020304 abnormal horn morphology lack of the hard pointed parts that grows on the head of some animals http://purl.obolibrary.org/obo/MP_0020307 abnormal creatine kinase activity http://purl.obolibrary.org/obo/MP_0005319 abnormal enzyme/ coenzyme level altered ability of to catalyze the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+). http://purl.obolibrary.org/obo/MP_0020308 decreased creatine kinase activity http://purl.obolibrary.org/obo/MP_0020307 abnormal creatine kinase activity reduced ability of to catalyze the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+). http://purl.obolibrary.org/obo/MP_0020309 increased creatine kinase activity http://purl.obolibrary.org/obo/MP_0020307 abnormal creatine kinase activity increased ability of to catalyze the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+). http://purl.obolibrary.org/obo/MP_0020310 abnormal hydroxymethylbilane synthase activity http://purl.obolibrary.org/obo/MP_0005319 abnormal enzyme/ coenzyme level altered ability of to catalyze the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+). http://purl.obolibrary.org/obo/MP_0020311 decreased hydroxymethylbilane synthase activity http://purl.obolibrary.org/obo/MP_0020310 abnormal hydroxymethylbilane synthase activity reduced ability of to catalyze the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+). http://purl.obolibrary.org/obo/MP_0020312 increased hydroxymethylbilane synthase activity http://purl.obolibrary.org/obo/MP_0020310 abnormal hydroxymethylbilane synthase activity increased ability of to catalyze the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+). http://purl.obolibrary.org/obo/MP_0020313 abnormal palmitoyl-(protein) hydrolase activity http://purl.obolibrary.org/obo/MP_0005319 abnormal enzyme/ coenzyme level altered ability of to catalyze the reaction: palmitoyl-protein + H2O = palmitate + protein. http://purl.obolibrary.org/obo/MP_0020314 decreased palmitoyl-(protein) hydrolase activity http://purl.obolibrary.org/obo/MP_0020313 abnormal palmitoyl-(protein) hydrolase activity reduced ability of to catalyze the reaction: palmitoyl-protein + H2O = palmitate + protein. http://purl.obolibrary.org/obo/MP_0020315 increased palmitoyl-(protein) hydrolase activity http://purl.obolibrary.org/obo/MP_0020313 abnormal palmitoyl-(protein) hydrolase activity increased ability of to catalyze the reaction: palmitoyl-protein + H2O = palmitate + protein. http://purl.obolibrary.org/obo/MP_3000001 abnormal gastrula morphology http://purl.obolibrary.org/obo/MP_0002085 abnormal embryonic tissue morphology any structural anomaly of the pear shaped trilaminar embryonic stage in which the primititve streak elongates, the epiblast cells migrate medially towards the streak, enter the primitive groove and migrate laterally to organize into the intraembryonic mesoderm (epithelio-mesenchymal transition) between the embryonic ectoderm and primitive endoderm; the notochordal process forms and extends, and the disc becomes pear shaped as the notochordal process grows http://purl.obolibrary.org/obo/MP_3000003 abnormal Ebner's gland morphology http://purl.obolibrary.org/obo/MP_0000613 abnormal salivary gland morphology any structural anomaly of the serous salivary glands which reside adjacent to the moats surrounding the circumvallate and foliate papillae just anterior to the posterior third of the tongue, anterior to the terminal sulcus; these exocrine glands secrete lingual lipase initiating the process of lipid hydrolysis in the mouth and empty their serous secretion into the base of the moats around the foliate and circumvallate papillae; their secretion presumably flushes material from the moat to enable the taste buds to respond rapidly to changing stimuli. http://purl.obolibrary.org/obo/MP_3000004 abnormal nictitating membrane morphology http://purl.obolibrary.org/obo/MP_0001340 abnormal eyelid morphology any structural anomaly of the translucent fold of the mucous membrane of the conjunctiva present in some animals that can be drawn across the eye for protection and to moisten it while maintaining visibility; in many mammals, a small, vestigial portion of the membrane remains in the corner of the eye; in mice, the nictitating membrane is very small and composed of a very thin core of cartilage covered by loose connective tissue http://purl.obolibrary.org/obo/MP_3000005 abnormal lacrimal sac morphology http://purl.obolibrary.org/obo/MP_0001346 abnormal lacrimal gland morphology any structural anomaly of the upper dilated end of the nasolacrimal duct that is lodged in a deep groove formed by the lacrimal bone and frontal process of the maxilla; it connects the lacrimal canaliculi, which drain tears from the eye's surface, and the nasolacrimal duct, which conveys this fluid into the nasal cavity; like the nasolacrimal duct, the sac is lined by stratified columnar epithelium with mucus-secreting goblet cells, and is surrounded by connective tissue http://purl.obolibrary.org/obo/CHEBI_60545 spiroketalamine fungicide http://purl.obolibrary.org/obo/CHEBI_24127 fungicide A class of fungicides whose members contain both a spiroketal moiety and an amino group. http://purl.obolibrary.org/obo/CHEBI_60575 phenoxy herbicide http://purl.obolibrary.org/obo/CHEBI_24527 herbicide Any member of the class of herbicides whose members contain a phenoxy or substituted phenoxy group. http://purl.obolibrary.org/obo/CHEBI_60576 phenoxyacetic herbicide http://purl.obolibrary.org/obo/CHEBI_60575 phenoxy herbicide Phenoxy herbicides whose members contain a (substituted) phenoxyacetic acid substructure, including salts and esters of (substituted) phenoxyacetic acid. http://purl.obolibrary.org/obo/RO_0002577 system http://purl.obolibrary.org/obo/BFO_0000040 material entity A material entity consisting of multiple components that are causally integrated. http://purl.obolibrary.org/obo/MP_0001261 obese http://purl.obolibrary.org/obo/MP_0001260 increased body weight a status with body weight that is grossly above the average, acceptable or desirable weight, usually due to accumulation of excess fat tissue in the body http://purl.obolibrary.org/obo/CHEBI_50188 provitamin http://purl.obolibrary.org/obo/CHEBI_24432 biological role http://purl.obolibrary.org/obo/CHEBI_75835 anti-anaemic agent http://purl.obolibrary.org/obo/CHEBI_33232 application http://purl.obolibrary.org/obo/CHEBI_38499 mitochondrial cytochrome-bc1 complex inhibitor http://purl.obolibrary.org/obo/CHEBI_25355 mitochondrial respiratory-chain inhibitor http://purl.obolibrary.org/obo/CHEBI_38498 mitochondrial NADH:ubiquinone reductase inhibitor http://purl.obolibrary.org/obo/CHEBI_25355 mitochondrial respiratory-chain inhibitor http://purl.obolibrary.org/obo/MP_0012614 abnormal circulating factor IX level http://purl.obolibrary.org/obo/MP_0001570 abnormal circulating enzyme level http://purl.obolibrary.org/obo/MP_0012617 abnormal circulating factor X level http://purl.obolibrary.org/obo/MP_0001570 abnormal circulating enzyme level http://purl.obolibrary.org/obo/MP_0012620 abnormal circulating factor XIII level http://purl.obolibrary.org/obo/MP_0001570 abnormal circulating enzyme level http://purl.obolibrary.org/obo/MP_0012060 diaphragm muscle hyperplasia http://purl.obolibrary.org/obo/MP_0002279 abnormal diaphragm morphology http://purl.obolibrary.org/obo/MP_0012115 abnormal trophectoderm cell proliferation http://purl.obolibrary.org/obo/MP_0004264 abnormal extraembryonic tissue physiology http://purl.obolibrary.org/obo/MP_0012611 abnormal ceruloplasmin level http://purl.obolibrary.org/obo/MP_0005319 abnormal enzyme/ coenzyme level http://purl.obolibrary.org/obo/MP_0012628 abnormal glutathione reductase level http://purl.obolibrary.org/obo/MP_0005319 abnormal enzyme/ coenzyme level http://purl.obolibrary.org/obo/MP_0012649 abnormal catalase level http://purl.obolibrary.org/obo/MP_0005319 abnormal enzyme/ coenzyme level http://purl.obolibrary.org/obo/MP_0012658 abnormal superoxide dismutase level http://purl.obolibrary.org/obo/MP_0005319 abnormal enzyme/ coenzyme level http://purl.obolibrary.org/obo/MP_0012571 increased mammary gland tumor incidence in virgin females http://purl.obolibrary.org/obo/MP_0010299 increased mammary gland tumor incidence http://purl.obolibrary.org/obo/MP_0011510 biventricular, discordant atrioventricular connection http://purl.obolibrary.org/obo/MP_0010435 abnormal heart atrium and ventricle connection http://purl.obolibrary.org/obo/MP_0011511 biventricular, ambiguous atrioventricular connection http://purl.obolibrary.org/obo/MP_0010435 abnormal heart atrium and ventricle connection http://purl.obolibrary.org/obo/MP_0012112 increased inner cell mass proliferation http://purl.obolibrary.org/obo/MP_0004966 abnormal inner cell mass proliferation http://purl.obolibrary.org/obo/MP_0012113 decreased inner cell mass proliferation http://purl.obolibrary.org/obo/MP_0004966 abnormal inner cell mass proliferation http://purl.obolibrary.org/obo/MP_0012114 absent inner cell mass proliferation http://purl.obolibrary.org/obo/MP_0004966 abnormal inner cell mass proliferation http://purl.obolibrary.org/obo/MP_0012640 abnormal benz (alpha) pyrene hydroxylase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity http://purl.obolibrary.org/obo/MP_0012646 abnormal urokinase activity http://purl.obolibrary.org/obo/MP_0005584 abnormal enzyme/coenzyme activity http://purl.obolibrary.org/obo/MP_0012444 thin hippocampus molecular cell layer http://purl.obolibrary.org/obo/MP_0008286 abnormal hippocampus molecular cell layer http://purl.obolibrary.org/obo/MP_0012600 abnormal alpha-fetoprotein level http://purl.obolibrary.org/obo/MP_0008469 abnormal protein level http://purl.obolibrary.org/obo/MP_0012603 abnormal glutathione level http://purl.obolibrary.org/obo/MP_0008469 abnormal protein level http://purl.obolibrary.org/obo/MP_0011716 abnormal interleukin-8 secretion http://purl.obolibrary.org/obo/MP_0008568 abnormal interleukin secretion http://purl.obolibrary.org/obo/MP_0011713 abnormal circulating interleukin-8 level http://purl.obolibrary.org/obo/MP_0008588 abnormal circulating interleukin level http://purl.obolibrary.org/obo/MP_0011671 balanced complete atrioventricular canal http://purl.obolibrary.org/obo/MP_0010413 complete atrioventricular septal defect http://purl.obolibrary.org/obo/MP_0011673 unbalanced complete common atrioventricular canal http://purl.obolibrary.org/obo/MP_0010413 complete atrioventricular septal defect http://purl.obolibrary.org/obo/MP_0011674 multiple major aortopulmonary collateral arteries http://purl.obolibrary.org/obo/MP_0010635 aorta pulmonary collateral arteries http://purl.obolibrary.org/obo/MP_0012446 thin hippocampus stratum oriens http://purl.obolibrary.org/obo/MP_0011150 abnormal hippocampus stratum oriens morphology http://purl.obolibrary.org/obo/MP_0012445 thin hippocampus stratum radiatum http://purl.obolibrary.org/obo/MP_0011151 abnormal hippocampus stratum radiatum morphology http://purl.obolibrary.org/obo/MP_0012608 abnormal complement C5 level http://purl.obolibrary.org/obo/MP_0011566 abnormal complement protein level http://purl.obolibrary.org/obo/MP_0012232 abnormal ceramide level http://purl.obolibrary.org/obo/MP_0012230 abnormal sphingolipid level http://purl.obolibrary.org/obo/MP_0012233 abnormal acidic glycosphingolipid level http://purl.obolibrary.org/obo/MP_0012230 abnormal sphingolipid level http://purl.obolibrary.org/obo/ENVO_00000000 geographic feature http://purl.obolibrary.org/obo/ENVO_00002297 environmental feature http://purl.obolibrary.org/obo/ENVO_00002006 water http://purl.obolibrary.org/obo/ENVO_00010483 environmental material http://purl.obolibrary.org/obo/ENVO_0010001 anthropogenic environmental material http://purl.obolibrary.org/obo/ENVO_00010483 environmental material http://purl.obolibrary.org/obo/ENVO_01000266 water vapour http://purl.obolibrary.org/obo/ENVO_00010483 environmental material http://purl.obolibrary.org/obo/ENVO_01000451 atmospheric carbon dioxide http://purl.obolibrary.org/obo/ENVO_00010483 environmental material http://purl.obolibrary.org/obo/ENVO_01000537 atmospheric ozone http://purl.obolibrary.org/obo/ENVO_00010483 environmental material http://purl.obolibrary.org/obo/CHEBI_35625 beta-lactamase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_35457 angiotensin-converting enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_35674 antihypertensive agent http://purl.obolibrary.org/obo/CHEBI_35634 xanthine oxidase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_50423 NADPH oxidase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_75429 glycine decarboxylase inhibitor http://purl.obolibrary.org/obo/CHEBI_23924 enzyme inhibitor http://purl.obolibrary.org/obo/CHEBI_63046 emulsifier http://purl.obolibrary.org/obo/CHEBI_51086 chemical role http://purl.obolibrary.org/obo/CHEBI_26842 systemic acquired resistance inducing compounds http://purl.obolibrary.org/obo/CHEBI_35703 xenobiotic http://purl.obolibrary.org/obo/CHEBI_27334 xenobiotic organic ethers http://purl.obolibrary.org/obo/CHEBI_35703 xenobiotic http://purl.obolibrary.org/obo/CHEBI_27090 triaziquone http://purl.obolibrary.org/obo/CHEBI_25435 mutagen http://purl.obolibrary.org/obo/CHEBI_38956 ectoparasiticide http://purl.obolibrary.org/obo/CHEBI_35442 antiparasitic agent http://purl.obolibrary.org/obo/CHEBI_38809 ryanodine receptor modulator http://purl.obolibrary.org/obo/CHEBI_38808 calcium channel modulator http://purl.obolibrary.org/obo/GO_0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen http://purl.obolibrary.org/obo/GO_0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen http://purl.obolibrary.org/obo/GO_0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen http://purl.obolibrary.org/obo/GO_0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen http://purl.obolibrary.org/obo/GO_0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen http://purl.obolibrary.org/obo/GO_0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen http://purl.obolibrary.org/obo/GO_0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen http://purl.obolibrary.org/obo/GO_0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen http://purl.obolibrary.org/obo/GO_0004540 ribonuclease activity http://purl.obolibrary.org/obo/GO_0004518 nuclease activity http://purl.obolibrary.org/obo/GO_0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters http://purl.obolibrary.org/obo/GO_0004519 endonuclease activity http://purl.obolibrary.org/obo/GO_0016891 endoribonuclease activity, producing 5'-phosphomonoesters http://purl.obolibrary.org/obo/GO_0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters http://purl.obolibrary.org/obo/GO_0004629 phospholipase C activity http://purl.obolibrary.org/obo/GO_0008081 phosphoric diester hydrolase activity http://purl.obolibrary.org/obo/GO_0019199 transmembrane receptor protein kinase activity http://purl.obolibrary.org/obo/GO_0004888 transmembrane signaling receptor activity http://purl.obolibrary.org/obo/GO_0004955 prostaglandin receptor activity http://purl.obolibrary.org/obo/GO_0004954 prostanoid receptor activity http://purl.obolibrary.org/obo/GO_0022857 transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0005215 transporter activity http://purl.obolibrary.org/obo/GO_0022892 substrate-specific transporter activity http://purl.obolibrary.org/obo/GO_0005215 transporter activity http://purl.obolibrary.org/obo/GO_0022839 ion gated channel activity http://purl.obolibrary.org/obo/GO_0022836 gated channel activity http://purl.obolibrary.org/obo/GO_0015278 calcium-release channel activity http://purl.obolibrary.org/obo/GO_0015276 ligand-gated ion channel activity http://purl.obolibrary.org/obo/GO_0016020 membrane http://purl.obolibrary.org/obo/GO_0005575 cellular_component http://purl.obolibrary.org/obo/GO_0044464 cell part http://purl.obolibrary.org/obo/GO_0005575 cellular_component http://purl.obolibrary.org/obo/GO_0032991 macromolecular complex http://purl.obolibrary.org/obo/GO_0005575 cellular_component http://purl.obolibrary.org/obo/GO_0043226 organelle http://purl.obolibrary.org/obo/GO_0005575 cellular_component http://purl.obolibrary.org/obo/GO_0044422 organelle part http://purl.obolibrary.org/obo/GO_0005575 cellular_component http://purl.obolibrary.org/obo/GO_0044425 membrane part http://purl.obolibrary.org/obo/GO_0005575 cellular_component http://purl.obolibrary.org/obo/GO_0015630 microtubule cytoskeleton http://purl.obolibrary.org/obo/GO_0005856 cytoskeleton http://purl.obolibrary.org/obo/GO_0005881 cytoplasmic microtubule http://purl.obolibrary.org/obo/GO_0044444 cytoplasmic part http://purl.obolibrary.org/obo/GO_0044262 cellular carbohydrate metabolic process http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process http://purl.obolibrary.org/obo/GO_0044723 single-organism carbohydrate metabolic process http://purl.obolibrary.org/obo/GO_0044710 single-organism metabolic process http://purl.obolibrary.org/obo/GO_0005976 polysaccharide metabolic process http://purl.obolibrary.org/obo/GO_0043170 macromolecule metabolic process http://purl.obolibrary.org/obo/GO_0046349 amino sugar biosynthetic process http://purl.obolibrary.org/obo/GO_1901137 carbohydrate derivative biosynthetic process http://purl.obolibrary.org/obo/GO_1901071 glucosamine-containing compound metabolic process http://purl.obolibrary.org/obo/GO_0006040 amino sugar metabolic process http://purl.obolibrary.org/obo/GO_0009250 glucan biosynthetic process http://purl.obolibrary.org/obo/GO_0033692 cellular polysaccharide biosynthetic process http://purl.obolibrary.org/obo/GO_0051273 beta-glucan metabolic process http://purl.obolibrary.org/obo/GO_0006073 cellular glucan metabolic process http://purl.obolibrary.org/obo/GO_0043436 oxoacid metabolic process http://purl.obolibrary.org/obo/GO_0006082 organic acid metabolic process http://purl.obolibrary.org/obo/GO_0016053 organic acid biosynthetic process http://purl.obolibrary.org/obo/GO_0044283 small molecule biosynthetic process http://purl.obolibrary.org/obo/GO_0019684 photosynthesis, light reaction http://purl.obolibrary.org/obo/GO_0006091 generation of precursor metabolites and energy http://purl.obolibrary.org/obo/GO_0022900 electron transport chain http://purl.obolibrary.org/obo/GO_0044763 single-organism cellular process http://purl.obolibrary.org/obo/GO_0043255 regulation of carbohydrate biosynthetic process http://purl.obolibrary.org/obo/GO_0009889 regulation of biosynthetic process http://purl.obolibrary.org/obo/GO_0032881 regulation of polysaccharide metabolic process http://purl.obolibrary.org/obo/GO_0060255 regulation of macromolecule metabolic process http://purl.obolibrary.org/obo/GO_0010675 regulation of cellular carbohydrate metabolic process http://purl.obolibrary.org/obo/GO_0031323 regulation of cellular metabolic process http://purl.obolibrary.org/obo/GO_0045913 positive regulation of carbohydrate metabolic process http://purl.obolibrary.org/obo/GO_0009893 positive regulation of metabolic process http://purl.obolibrary.org/obo/GO_0034655 nucleobase-containing compound catabolic process http://purl.obolibrary.org/obo/GO_1901361 organic cyclic compound catabolic process http://purl.obolibrary.org/obo/GO_0055086 nucleobase-containing small molecule metabolic process http://purl.obolibrary.org/obo/GO_0044763 single-organism cellular process http://purl.obolibrary.org/obo/GO_0090304 nucleic acid metabolic process http://purl.obolibrary.org/obo/GO_0043170 macromolecule metabolic process http://purl.obolibrary.org/obo/GO_0034654 nucleobase-containing compound biosynthetic process http://purl.obolibrary.org/obo/GO_1901362 organic cyclic compound biosynthetic process http://purl.obolibrary.org/obo/GO_0030811 regulation of nucleotide catabolic process http://purl.obolibrary.org/obo/GO_0031329 regulation of cellular catabolic process http://purl.obolibrary.org/obo/GO_0045981 positive regulation of nucleotide metabolic process http://purl.obolibrary.org/obo/GO_0045937 positive regulation of phosphate metabolic process http://purl.obolibrary.org/obo/GO_1900542 regulation of purine nucleotide metabolic process http://purl.obolibrary.org/obo/GO_0006140 regulation of nucleotide metabolic process http://purl.obolibrary.org/obo/GO_0046130 purine ribonucleoside catabolic process http://purl.obolibrary.org/obo/GO_0046128 purine ribonucleoside metabolic process http://purl.obolibrary.org/obo/GO_0009150 purine ribonucleotide metabolic process http://purl.obolibrary.org/obo/GO_0009259 ribonucleotide metabolic process http://purl.obolibrary.org/obo/GO_0009154 purine ribonucleotide catabolic process http://purl.obolibrary.org/obo/GO_0009261 ribonucleotide catabolic process http://purl.obolibrary.org/obo/GO_0090329 regulation of DNA-dependent DNA replication http://purl.obolibrary.org/obo/GO_0006275 regulation of DNA replication http://purl.obolibrary.org/obo/GO_0045740 positive regulation of DNA replication http://purl.obolibrary.org/obo/GO_0051054 positive regulation of DNA metabolic process http://purl.obolibrary.org/obo/GO_0044728 DNA methylation or demethylation http://purl.obolibrary.org/obo/GO_0006304 DNA modification http://purl.obolibrary.org/obo/GO_0045727 positive regulation of translation http://purl.obolibrary.org/obo/GO_0032270 positive regulation of cellular protein metabolic process http://purl.obolibrary.org/obo/GO_0070129 regulation of mitochondrial translation http://purl.obolibrary.org/obo/GO_0010821 regulation of mitochondrion organization http://purl.obolibrary.org/obo/GO_0035335 peptidyl-tyrosine dephosphorylation http://purl.obolibrary.org/obo/GO_0006470 protein dephosphorylation http://purl.obolibrary.org/obo/GO_0016575 histone deacetylation http://purl.obolibrary.org/obo/GO_0016570 histone modification http://purl.obolibrary.org/obo/GO_0042438 melanin biosynthetic process http://purl.obolibrary.org/obo/GO_0046189 phenol-containing compound biosynthetic process http://purl.obolibrary.org/obo/GO_0006568 tryptophan metabolic process http://purl.obolibrary.org/obo/GO_1901605 alpha-amino acid metabolic process http://purl.obolibrary.org/obo/GO_0046219 indolalkylamine biosynthetic process http://purl.obolibrary.org/obo/GO_0042435 indole-containing compound biosynthetic process http://purl.obolibrary.org/obo/GO_0008610 lipid biosynthetic process http://purl.obolibrary.org/obo/GO_0044711 single-organism biosynthetic process http://purl.obolibrary.org/obo/GO_0044255 cellular lipid metabolic process http://purl.obolibrary.org/obo/GO_0044763 single-organism cellular process http://purl.obolibrary.org/obo/GO_0046488 phosphatidylinositol metabolic process http://purl.obolibrary.org/obo/GO_0006650 glycerophospholipid metabolic process http://purl.obolibrary.org/obo/GO_0009072 aromatic amino acid family metabolic process http://purl.obolibrary.org/obo/GO_1901360 organic cyclic compound metabolic process http://purl.obolibrary.org/obo/GO_0018958 phenol-containing compound metabolic process http://purl.obolibrary.org/obo/GO_1901360 organic cyclic compound metabolic process http://purl.obolibrary.org/obo/GO_0019439 aromatic compound catabolic process http://purl.obolibrary.org/obo/GO_0044248 cellular catabolic process http://purl.obolibrary.org/obo/GO_0042430 indole-containing compound metabolic process http://purl.obolibrary.org/obo/GO_1901564 organonitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_0072521 purine-containing compound metabolic process http://purl.obolibrary.org/obo/GO_1901564 organonitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_0019438 aromatic compound biosynthetic process http://purl.obolibrary.org/obo/GO_0044249 cellular biosynthetic process http://purl.obolibrary.org/obo/GO_0009117 nucleotide metabolic process http://purl.obolibrary.org/obo/GO_0006753 nucleoside phosphate metabolic process http://purl.obolibrary.org/obo/GO_0009123 nucleoside monophosphate metabolic process http://purl.obolibrary.org/obo/GO_0006753 nucleoside phosphate metabolic process http://purl.obolibrary.org/obo/GO_0009141 nucleoside triphosphate metabolic process http://purl.obolibrary.org/obo/GO_0006753 nucleoside phosphate metabolic process http://purl.obolibrary.org/obo/GO_1901292 nucleoside phosphate catabolic process http://purl.obolibrary.org/obo/GO_0046434 organophosphate catabolic process http://purl.obolibrary.org/obo/GO_0019637 organophosphate metabolic process http://purl.obolibrary.org/obo/GO_0071704 organic substance metabolic process http://purl.obolibrary.org/obo/GO_0016310 phosphorylation http://purl.obolibrary.org/obo/GO_0006796 phosphate-containing compound metabolic process http://purl.obolibrary.org/obo/GO_0016311 dephosphorylation http://purl.obolibrary.org/obo/GO_0006796 phosphate-containing compound metabolic process http://purl.obolibrary.org/obo/GO_0019693 ribose phosphate metabolic process http://purl.obolibrary.org/obo/GO_1901135 carbohydrate derivative metabolic process http://purl.obolibrary.org/obo/GO_0034641 cellular nitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process http://purl.obolibrary.org/obo/GO_1901564 organonitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_0071704 organic substance metabolic process http://purl.obolibrary.org/obo/GO_0044765 single-organism transport http://purl.obolibrary.org/obo/GO_0044699 single-organism process http://purl.obolibrary.org/obo/GO_0046907 intracellular transport http://purl.obolibrary.org/obo/GO_0051649 establishment of localization in cell http://purl.obolibrary.org/obo/GO_0071702 organic substance transport http://purl.obolibrary.org/obo/GO_0006810 transport http://purl.obolibrary.org/obo/GO_0071705 nitrogen compound transport http://purl.obolibrary.org/obo/GO_0006810 transport http://purl.obolibrary.org/obo/GO_0034220 ion transmembrane transport http://purl.obolibrary.org/obo/GO_0055085 transmembrane transport http://purl.obolibrary.org/obo/GO_0015672 monovalent inorganic cation transport http://purl.obolibrary.org/obo/GO_0006812 cation transport http://purl.obolibrary.org/obo/GO_0072511 divalent inorganic cation transport http://purl.obolibrary.org/obo/GO_0006812 cation transport http://purl.obolibrary.org/obo/GO_0006837 serotonin transport http://purl.obolibrary.org/obo/GO_0015844 monoamine transport http://purl.obolibrary.org/obo/GO_0030001 metal ion transport http://purl.obolibrary.org/obo/GO_0006812 cation transport http://purl.obolibrary.org/obo/GO_0015872 dopamine transport http://purl.obolibrary.org/obo/GO_0051937 catecholamine transport http://purl.obolibrary.org/obo/GO_0071804 cellular potassium ion transport http://purl.obolibrary.org/obo/GO_0044763 single-organism cellular process http://purl.obolibrary.org/obo/GO_0044341 sodium-dependent phosphate transport http://purl.obolibrary.org/obo/GO_0006817 phosphate ion transport http://purl.obolibrary.org/obo/GO_0015992 proton transport http://purl.obolibrary.org/obo/GO_0015672 monovalent inorganic cation transport http://purl.obolibrary.org/obo/GO_0015698 inorganic anion transport http://purl.obolibrary.org/obo/GO_0006820 anion transport http://purl.obolibrary.org/obo/GO_0007005 mitochondrion organization http://purl.obolibrary.org/obo/GO_0006996 organelle organization http://purl.obolibrary.org/obo/GO_0051276 chromosome organization http://purl.obolibrary.org/obo/GO_0006996 organelle organization http://purl.obolibrary.org/obo/GO_0007169 transmembrane receptor protein tyrosine kinase signaling pathway http://purl.obolibrary.org/obo/GO_0007167 enzyme linked receptor protein signaling pathway http://purl.obolibrary.org/obo/GO_0038084 vascular endothelial growth factor signaling pathway http://purl.obolibrary.org/obo/GO_0035924 cellular response to vascular endothelial growth factor stimulus http://purl.obolibrary.org/obo/GO_0008543 fibroblast growth factor receptor signaling pathway http://purl.obolibrary.org/obo/GO_0044344 cellular response to fibroblast growth factor stimulus http://purl.obolibrary.org/obo/GO_0035235 ionotropic glutamate receptor signaling pathway http://purl.obolibrary.org/obo/GO_0007215 glutamate receptor signaling pathway http://purl.obolibrary.org/obo/GO_0007270 neuron-neuron synaptic transmission http://purl.obolibrary.org/obo/GO_0007268 synaptic transmission http://purl.obolibrary.org/obo/GO_0007596 blood coagulation http://purl.obolibrary.org/obo/GO_0050817 coagulation http://purl.obolibrary.org/obo/GO_0007606 sensory perception of chemical stimulus http://purl.obolibrary.org/obo/GO_0007600 sensory perception http://purl.obolibrary.org/obo/GO_0007608 sensory perception of smell http://purl.obolibrary.org/obo/GO_0007606 sensory perception of chemical stimulus http://purl.obolibrary.org/obo/GO_0032259 methylation http://purl.obolibrary.org/obo/GO_0008152 metabolic process http://purl.obolibrary.org/obo/GO_0044238 primary metabolic process http://purl.obolibrary.org/obo/GO_0008152 metabolic process http://purl.obolibrary.org/obo/GO_0044710 single-organism metabolic process http://purl.obolibrary.org/obo/GO_0044699 single-organism process http://purl.obolibrary.org/obo/GO_0071704 organic substance metabolic process http://purl.obolibrary.org/obo/GO_0008152 metabolic process http://purl.obolibrary.org/obo/GO_0009058 biosynthetic process http://purl.obolibrary.org/obo/GO_0008152 metabolic process http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process http://purl.obolibrary.org/obo/GO_0009987 cellular process http://purl.obolibrary.org/obo/GO_0009056 catabolic process http://purl.obolibrary.org/obo/GO_0008152 metabolic process http://purl.obolibrary.org/obo/GO_0006633 fatty acid biosynthetic process http://purl.obolibrary.org/obo/GO_0072330 monocarboxylic acid biosynthetic process http://purl.obolibrary.org/obo/GO_0009073 aromatic amino acid family biosynthetic process http://purl.obolibrary.org/obo/GO_1901362 organic cyclic compound biosynthetic process http://purl.obolibrary.org/obo/GO_0009164 nucleoside catabolic process http://purl.obolibrary.org/obo/GO_1901658 glycosyl compound catabolic process http://purl.obolibrary.org/obo/GO_0042278 purine nucleoside metabolic process http://purl.obolibrary.org/obo/GO_0072521 purine-containing compound metabolic process http://purl.obolibrary.org/obo/GO_0009119 ribonucleoside metabolic process http://purl.obolibrary.org/obo/GO_0009116 nucleoside metabolic process http://purl.obolibrary.org/obo/GO_0009166 nucleotide catabolic process http://purl.obolibrary.org/obo/GO_1901292 nucleoside phosphate catabolic process http://purl.obolibrary.org/obo/GO_0009259 ribonucleotide metabolic process http://purl.obolibrary.org/obo/GO_0019693 ribose phosphate metabolic process http://purl.obolibrary.org/obo/GO_0042454 ribonucleoside catabolic process http://purl.obolibrary.org/obo/GO_0009119 ribonucleoside metabolic process http://purl.obolibrary.org/obo/GO_0009261 ribonucleotide catabolic process http://purl.obolibrary.org/obo/GO_0009259 ribonucleotide metabolic process http://purl.obolibrary.org/obo/GO_0051274 beta-glucan biosynthetic process http://purl.obolibrary.org/obo/GO_0051273 beta-glucan metabolic process http://purl.obolibrary.org/obo/GO_2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity http://purl.obolibrary.org/obo/GO_0032412 regulation of ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_2000273 positive regulation of receptor activity http://purl.obolibrary.org/obo/GO_0044093 positive regulation of molecular function http://purl.obolibrary.org/obo/GO_2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity http://purl.obolibrary.org/obo/GO_0032412 regulation of ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0019217 regulation of fatty acid metabolic process http://purl.obolibrary.org/obo/GO_0019216 regulation of lipid metabolic process http://purl.obolibrary.org/obo/GO_0006521 regulation of cellular amino acid metabolic process http://purl.obolibrary.org/obo/GO_0080090 regulation of primary metabolic process http://purl.obolibrary.org/obo/GO_0072364 regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0006357 regulation of transcription from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0032951 regulation of beta-glucan biosynthetic process http://purl.obolibrary.org/obo/GO_0032950 regulation of beta-glucan metabolic process http://purl.obolibrary.org/obo/GO_0008324 cation transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015075 ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0042625 ATPase activity, coupled to transmembrane movement of ions http://purl.obolibrary.org/obo/GO_0042626 ATPase activity, coupled to transmembrane movement of substances http://purl.obolibrary.org/obo/GO_0008556 potassium-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0019829 cation-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0022824 transmitter-gated ion channel activity http://purl.obolibrary.org/obo/GO_0022835 transmitter-gated channel activity http://purl.obolibrary.org/obo/GO_0006814 sodium ion transport http://purl.obolibrary.org/obo/GO_0030001 metal ion transport http://purl.obolibrary.org/obo/GO_0051937 catecholamine transport http://purl.obolibrary.org/obo/GO_0015850 organic hydroxy compound transport http://purl.obolibrary.org/obo/GO_0005886 plasma membrane http://purl.obolibrary.org/obo/GO_0044464 cell part http://purl.obolibrary.org/obo/GO_0031090 organelle membrane http://purl.obolibrary.org/obo/GO_0044422 organelle part http://purl.obolibrary.org/obo/GO_0034357 photosynthetic membrane http://purl.obolibrary.org/obo/GO_0044436 thylakoid part http://purl.obolibrary.org/obo/GO_0005887 integral to plasma membrane http://purl.obolibrary.org/obo/GO_0031226 intrinsic to plasma membrane http://purl.obolibrary.org/obo/GO_0006996 organelle organization http://purl.obolibrary.org/obo/GO_0044763 single-organism cellular process http://purl.obolibrary.org/obo/GO_0004806 triglyceride lipase activity http://purl.obolibrary.org/obo/GO_0052689 carboxylic ester hydrolase activity http://purl.obolibrary.org/obo/GO_0006468 protein phosphorylation http://purl.obolibrary.org/obo/GO_0006464 cellular protein modification process http://purl.obolibrary.org/obo/GO_0046834 lipid phosphorylation http://purl.obolibrary.org/obo/GO_0030258 lipid modification http://purl.obolibrary.org/obo/GO_0016570 histone modification http://purl.obolibrary.org/obo/GO_0006464 cellular protein modification process http://purl.obolibrary.org/obo/GO_0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor http://purl.obolibrary.org/obo/GO_0016645 oxidoreductase activity, acting on the CH-NH group of donors http://purl.obolibrary.org/obo/GO_0008168 methyltransferase activity http://purl.obolibrary.org/obo/GO_0016741 transferase activity, transferring one-carbon groups http://purl.obolibrary.org/obo/GO_0016742 hydroxymethyl-, formyl- and related transferase activity http://purl.obolibrary.org/obo/GO_0016741 transferase activity, transferring one-carbon groups http://purl.obolibrary.org/obo/GO_0016298 lipase activity http://purl.obolibrary.org/obo/GO_0016788 hydrolase activity, acting on ester bonds http://purl.obolibrary.org/obo/GO_0042578 phosphoric ester hydrolase activity http://purl.obolibrary.org/obo/GO_0016788 hydrolase activity, acting on ester bonds http://purl.obolibrary.org/obo/GO_0052689 carboxylic ester hydrolase activity http://purl.obolibrary.org/obo/GO_0016788 hydrolase activity, acting on ester bonds http://purl.obolibrary.org/obo/GO_0004553 hydrolase activity, hydrolyzing O-glycosyl compounds http://purl.obolibrary.org/obo/GO_0016798 hydrolase activity, acting on glycosyl bonds http://purl.obolibrary.org/obo/GO_0018108 peptidyl-tyrosine phosphorylation http://purl.obolibrary.org/obo/GO_0006468 protein phosphorylation http://purl.obolibrary.org/obo/GO_0046189 phenol-containing compound biosynthetic process http://purl.obolibrary.org/obo/GO_1901362 organic cyclic compound biosynthetic process http://purl.obolibrary.org/obo/GO_0042304 regulation of fatty acid biosynthetic process http://purl.obolibrary.org/obo/GO_0031326 regulation of cellular biosynthetic process http://purl.obolibrary.org/obo/GO_0045923 positive regulation of fatty acid metabolic process http://purl.obolibrary.org/obo/GO_0031325 positive regulation of cellular metabolic process http://purl.obolibrary.org/obo/GO_0051052 regulation of DNA metabolic process http://purl.obolibrary.org/obo/GO_0060255 regulation of macromolecule metabolic process http://purl.obolibrary.org/obo/GO_0051252 regulation of RNA metabolic process http://purl.obolibrary.org/obo/GO_0060255 regulation of macromolecule metabolic process http://purl.obolibrary.org/obo/GO_0032069 regulation of nuclease activity http://purl.obolibrary.org/obo/GO_0051336 regulation of hydrolase activity http://purl.obolibrary.org/obo/GO_0045935 positive regulation of nucleobase-containing compound metabolic process http://purl.obolibrary.org/obo/GO_0051173 positive regulation of nitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_0009118 regulation of nucleoside metabolic process http://purl.obolibrary.org/obo/GO_0019219 regulation of nucleobase-containing compound metabolic process http://purl.obolibrary.org/obo/GO_0042325 regulation of phosphorylation http://purl.obolibrary.org/obo/GO_0019220 regulation of phosphate metabolic process http://purl.obolibrary.org/obo/GO_0045937 positive regulation of phosphate metabolic process http://purl.obolibrary.org/obo/GO_0010562 positive regulation of phosphorus metabolic process http://purl.obolibrary.org/obo/GO_0035303 regulation of dephosphorylation http://purl.obolibrary.org/obo/GO_0019220 regulation of phosphate metabolic process http://purl.obolibrary.org/obo/GO_0072523 purine-containing compound catabolic process http://purl.obolibrary.org/obo/GO_1901565 organonitrogen compound catabolic process http://purl.obolibrary.org/obo/GO_0036211 protein modification process http://purl.obolibrary.org/obo/GO_0043412 macromolecule modification http://purl.obolibrary.org/obo/GO_0044267 cellular protein metabolic process http://purl.obolibrary.org/obo/GO_0044260 cellular macromolecule metabolic process http://purl.obolibrary.org/obo/GO_0046434 organophosphate catabolic process http://purl.obolibrary.org/obo/GO_1901575 organic substance catabolic process http://purl.obolibrary.org/obo/GO_0044550 secondary metabolite biosynthetic process http://purl.obolibrary.org/obo/GO_0044711 single-organism biosynthetic process http://purl.obolibrary.org/obo/GO_0032787 monocarboxylic acid metabolic process http://purl.obolibrary.org/obo/GO_0019752 carboxylic acid metabolic process http://purl.obolibrary.org/obo/GO_0006520 cellular amino acid metabolic process http://purl.obolibrary.org/obo/GO_1901564 organonitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_0046394 carboxylic acid biosynthetic process http://purl.obolibrary.org/obo/GO_0016053 organic acid biosynthetic process http://purl.obolibrary.org/obo/GO_0017134 fibroblast growth factor binding http://purl.obolibrary.org/obo/GO_0019838 growth factor binding http://purl.obolibrary.org/obo/GO_0038085 vascular endothelial growth factor binding http://purl.obolibrary.org/obo/GO_0019838 growth factor binding http://purl.obolibrary.org/obo/GO_0005501 retinoid binding http://purl.obolibrary.org/obo/GO_0019840 isoprenoid binding http://purl.obolibrary.org/obo/GO_0007155 cell adhesion http://purl.obolibrary.org/obo/GO_0044763 single-organism cellular process http://purl.obolibrary.org/obo/GO_0022851 GABA-gated chloride ion channel activity http://purl.obolibrary.org/obo/GO_0022824 transmitter-gated ion channel activity http://purl.obolibrary.org/obo/GO_0015276 ligand-gated ion channel activity http://purl.obolibrary.org/obo/GO_0022834 ligand-gated channel activity http://purl.obolibrary.org/obo/GO_0022891 substrate-specific transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0022892 substrate-specific transporter activity http://purl.obolibrary.org/obo/GO_0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances http://purl.obolibrary.org/obo/GO_0016817 hydrolase activity, acting on acid anhydrides http://purl.obolibrary.org/obo/GO_0022803 passive transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0022857 transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0022804 active transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0022857 transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015075 ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0022891 substrate-specific transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0022838 substrate-specific channel activity http://purl.obolibrary.org/obo/GO_0015267 channel activity http://purl.obolibrary.org/obo/GO_0050542 icosanoid binding http://purl.obolibrary.org/obo/GO_1901567 fatty acid derivative binding http://purl.obolibrary.org/obo/GO_0033293 monocarboxylic acid binding http://purl.obolibrary.org/obo/GO_0031406 carboxylic acid binding http://purl.obolibrary.org/obo/GO_0016597 amino acid binding http://purl.obolibrary.org/obo/GO_0031406 carboxylic acid binding http://purl.obolibrary.org/obo/GO_1902380 positive regulation of endoribonuclease activity http://purl.obolibrary.org/obo/GO_0060699 regulation of endoribonuclease activity http://purl.obolibrary.org/obo/GO_0043414 macromolecule methylation http://purl.obolibrary.org/obo/GO_0044260 cellular macromolecule metabolic process http://purl.obolibrary.org/obo/GO_0031399 regulation of protein modification process http://purl.obolibrary.org/obo/GO_0032268 regulation of cellular protein metabolic process http://purl.obolibrary.org/obo/GO_0032270 positive regulation of cellular protein metabolic process http://purl.obolibrary.org/obo/GO_0051247 positive regulation of protein metabolic process http://purl.obolibrary.org/obo/GO_0051000 positive regulation of nitric-oxide synthase activity http://purl.obolibrary.org/obo/GO_0050999 regulation of nitric-oxide synthase activity http://purl.obolibrary.org/obo/GO_0032773 positive regulation of monophenol monooxygenase activity http://purl.obolibrary.org/obo/GO_0032771 regulation of monophenol monooxygenase activity http://purl.obolibrary.org/obo/GO_0006631 fatty acid metabolic process http://purl.obolibrary.org/obo/GO_0044255 cellular lipid metabolic process http://purl.obolibrary.org/obo/GO_0072330 monocarboxylic acid biosynthetic process http://purl.obolibrary.org/obo/GO_0046394 carboxylic acid biosynthetic process http://purl.obolibrary.org/obo/GO_0042277 peptide binding http://purl.obolibrary.org/obo/GO_0033218 amide binding http://purl.obolibrary.org/obo/GO_0033240 positive regulation of cellular amine metabolic process http://purl.obolibrary.org/obo/GO_0051173 positive regulation of nitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_0033692 cellular polysaccharide biosynthetic process http://purl.obolibrary.org/obo/GO_0000271 polysaccharide biosynthetic process http://purl.obolibrary.org/obo/GO_0044106 cellular amine metabolic process http://purl.obolibrary.org/obo/GO_0009308 amine metabolic process http://purl.obolibrary.org/obo/GO_0044270 cellular nitrogen compound catabolic process http://purl.obolibrary.org/obo/GO_0044248 cellular catabolic process http://purl.obolibrary.org/obo/GO_0044271 cellular nitrogen compound biosynthetic process http://purl.obolibrary.org/obo/GO_0044249 cellular biosynthetic process http://purl.obolibrary.org/obo/GO_0006260 DNA replication http://purl.obolibrary.org/obo/GO_0006259 DNA metabolic process http://purl.obolibrary.org/obo/GO_0006351 transcription, DNA-templated http://purl.obolibrary.org/obo/GO_0032774 RNA biosynthetic process http://purl.obolibrary.org/obo/GO_0006412 translation http://purl.obolibrary.org/obo/GO_0044267 cellular protein metabolic process http://purl.obolibrary.org/obo/GO_0071897 DNA biosynthetic process http://purl.obolibrary.org/obo/GO_0034654 nucleobase-containing compound biosynthetic process http://purl.obolibrary.org/obo/GO_0008282 ATP-sensitive potassium channel complex http://purl.obolibrary.org/obo/GO_0044459 plasma membrane part http://purl.obolibrary.org/obo/GO_0034767 positive regulation of ion transmembrane transport http://purl.obolibrary.org/obo/GO_0043270 positive regulation of ion transport http://purl.obolibrary.org/obo/GO_1901379 regulation of potassium ion transmembrane transport http://purl.obolibrary.org/obo/GO_0043266 regulation of potassium ion transport http://purl.obolibrary.org/obo/GO_1902305 regulation of sodium ion transmembrane transport http://purl.obolibrary.org/obo/GO_0002028 regulation of sodium ion transport http://purl.obolibrary.org/obo/GO_0032412 regulation of ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0022898 regulation of transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0006464 cellular protein modification process http://purl.obolibrary.org/obo/GO_0044267 cellular protein metabolic process http://purl.obolibrary.org/obo/GO_0046128 purine ribonucleoside metabolic process http://purl.obolibrary.org/obo/GO_0009119 ribonucleoside metabolic process http://purl.obolibrary.org/obo/GO_0042435 indole-containing compound biosynthetic process http://purl.obolibrary.org/obo/GO_1901566 organonitrogen compound biosynthetic process http://purl.obolibrary.org/obo/GO_0046148 pigment biosynthetic process http://purl.obolibrary.org/obo/GO_0044711 single-organism biosynthetic process http://purl.obolibrary.org/obo/GO_0070324 thyroid hormone binding http://purl.obolibrary.org/obo/GO_0042562 hormone binding http://purl.obolibrary.org/obo/GO_0017046 peptide hormone binding http://purl.obolibrary.org/obo/GO_0042277 peptide binding http://purl.obolibrary.org/obo/GO_0008081 phosphoric diester hydrolase activity http://purl.obolibrary.org/obo/GO_0042578 phosphoric ester hydrolase activity http://purl.obolibrary.org/obo/GO_0016791 phosphatase activity http://purl.obolibrary.org/obo/GO_0042578 phosphoric ester hydrolase activity http://purl.obolibrary.org/obo/GO_0015833 peptide transport http://purl.obolibrary.org/obo/GO_0071702 organic substance transport http://purl.obolibrary.org/obo/GO_0051347 positive regulation of transferase activity http://purl.obolibrary.org/obo/GO_0051338 regulation of transferase activity http://purl.obolibrary.org/obo/GO_0051349 positive regulation of lyase activity http://purl.obolibrary.org/obo/GO_0051339 regulation of lyase activity http://purl.obolibrary.org/obo/GO_0051351 positive regulation of ligase activity http://purl.obolibrary.org/obo/GO_0051340 regulation of ligase activity http://purl.obolibrary.org/obo/GO_0010912 positive regulation of isomerase activity http://purl.obolibrary.org/obo/GO_0010911 regulation of isomerase activity http://purl.obolibrary.org/obo/GO_0051345 positive regulation of hydrolase activity http://purl.obolibrary.org/obo/GO_0051336 regulation of hydrolase activity http://purl.obolibrary.org/obo/GO_0051353 positive regulation of oxidoreductase activity http://purl.obolibrary.org/obo/GO_0051341 regulation of oxidoreductase activity http://purl.obolibrary.org/obo/GO_0019538 protein metabolic process http://purl.obolibrary.org/obo/GO_0044238 primary metabolic process http://purl.obolibrary.org/obo/GO_0043412 macromolecule modification http://purl.obolibrary.org/obo/GO_0043170 macromolecule metabolic process http://purl.obolibrary.org/obo/GO_0044260 cellular macromolecule metabolic process http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process http://purl.obolibrary.org/obo/GO_0009059 macromolecule biosynthetic process http://purl.obolibrary.org/obo/GO_1901576 organic substance biosynthetic process http://purl.obolibrary.org/obo/GO_0010467 gene expression http://purl.obolibrary.org/obo/GO_0043170 macromolecule metabolic process http://purl.obolibrary.org/obo/GO_0005739 mitochondrion http://purl.obolibrary.org/obo/GO_0044444 cytoplasmic part http://purl.obolibrary.org/obo/GO_0032885 regulation of polysaccharide biosynthetic process http://purl.obolibrary.org/obo/GO_0032881 regulation of polysaccharide metabolic process http://purl.obolibrary.org/obo/GO_0097503 sialylation http://purl.obolibrary.org/obo/GO_0043412 macromolecule modification http://purl.obolibrary.org/obo/GO_1900376 regulation of secondary metabolite biosynthetic process http://purl.obolibrary.org/obo/GO_0009889 regulation of biosynthetic process http://purl.obolibrary.org/obo/GO_0010966 regulation of phosphate transport http://purl.obolibrary.org/obo/GO_0044070 regulation of anion transport http://purl.obolibrary.org/obo/GO_0006576 cellular biogenic amine metabolic process http://purl.obolibrary.org/obo/GO_0044106 cellular amine metabolic process http://purl.obolibrary.org/obo/GO_0046700 heterocycle catabolic process http://purl.obolibrary.org/obo/GO_0046483 heterocycle metabolic process http://purl.obolibrary.org/obo/GO_0034637 cellular carbohydrate biosynthetic process http://purl.obolibrary.org/obo/GO_0044763 single-organism cellular process http://purl.obolibrary.org/obo/GO_0034645 cellular macromolecule biosynthetic process http://purl.obolibrary.org/obo/GO_0009059 macromolecule biosynthetic process http://purl.obolibrary.org/obo/GO_0018130 heterocycle biosynthetic process http://purl.obolibrary.org/obo/GO_0046483 heterocycle metabolic process http://purl.obolibrary.org/obo/GO_0046486 glycerolipid metabolic process http://purl.obolibrary.org/obo/GO_0044255 cellular lipid metabolic process http://purl.obolibrary.org/obo/GO_0030258 lipid modification http://purl.obolibrary.org/obo/GO_0044255 cellular lipid metabolic process http://purl.obolibrary.org/obo/GO_0044264 cellular polysaccharide metabolic process http://purl.obolibrary.org/obo/GO_0005976 polysaccharide metabolic process http://purl.obolibrary.org/obo/GO_0006259 DNA metabolic process http://purl.obolibrary.org/obo/GO_0090304 nucleic acid metabolic process http://purl.obolibrary.org/obo/GO_0016070 RNA metabolic process http://purl.obolibrary.org/obo/GO_0090304 nucleic acid metabolic process http://purl.obolibrary.org/obo/GO_0042180 cellular ketone metabolic process http://purl.obolibrary.org/obo/GO_0044763 single-organism cellular process http://purl.obolibrary.org/obo/GO_0044283 small molecule biosynthetic process http://purl.obolibrary.org/obo/GO_0044711 single-organism biosynthetic process http://purl.obolibrary.org/obo/GO_0071944 cell periphery http://purl.obolibrary.org/obo/GO_0044464 cell part http://purl.obolibrary.org/obo/GO_0005622 intracellular http://purl.obolibrary.org/obo/GO_0044464 cell part http://purl.obolibrary.org/obo/GO_0044424 intracellular part http://purl.obolibrary.org/obo/GO_0044464 cell part http://purl.obolibrary.org/obo/GO_0044459 plasma membrane part http://purl.obolibrary.org/obo/GO_0044425 membrane part http://purl.obolibrary.org/obo/GO_1990204 oxidoreductase complex http://purl.obolibrary.org/obo/GO_1902494 catalytic complex http://purl.obolibrary.org/obo/GO_0031975 envelope http://purl.obolibrary.org/obo/GO_0044464 cell part http://purl.obolibrary.org/obo/GO_0007267 cell-cell signaling http://purl.obolibrary.org/obo/GO_0007154 cell communication http://purl.obolibrary.org/obo/GO_0035637 multicellular organismal signaling http://purl.obolibrary.org/obo/GO_0044707 single-multicellular organism process http://purl.obolibrary.org/obo/GO_0019748 secondary metabolic process http://purl.obolibrary.org/obo/GO_0044710 single-organism metabolic process http://purl.obolibrary.org/obo/GO_0042440 pigment metabolic process http://purl.obolibrary.org/obo/GO_0044710 single-organism metabolic process http://purl.obolibrary.org/obo/GO_0044281 small molecule metabolic process http://purl.obolibrary.org/obo/GO_0044710 single-organism metabolic process http://purl.obolibrary.org/obo/GO_0055114 oxidation-reduction process http://purl.obolibrary.org/obo/GO_0044710 single-organism metabolic process http://purl.obolibrary.org/obo/GO_0044711 single-organism biosynthetic process http://purl.obolibrary.org/obo/GO_0009058 biosynthetic process http://purl.obolibrary.org/obo/GO_0044712 single-organism catabolic process http://purl.obolibrary.org/obo/GO_0009056 catabolic process http://purl.obolibrary.org/obo/GO_1901657 glycosyl compound metabolic process http://purl.obolibrary.org/obo/GO_0071704 organic substance metabolic process http://purl.obolibrary.org/obo/GO_0016051 carbohydrate biosynthetic process http://purl.obolibrary.org/obo/GO_0044711 single-organism biosynthetic process http://purl.obolibrary.org/obo/GO_0015837 amine transport http://purl.obolibrary.org/obo/GO_0071705 nitrogen compound transport http://purl.obolibrary.org/obo/GO_0015844 monoamine transport http://purl.obolibrary.org/obo/GO_0071705 nitrogen compound transport http://purl.obolibrary.org/obo/GO_0015850 organic hydroxy compound transport http://purl.obolibrary.org/obo/GO_0071702 organic substance transport http://purl.obolibrary.org/obo/GO_0042886 amide transport http://purl.obolibrary.org/obo/GO_0071705 nitrogen compound transport http://purl.obolibrary.org/obo/GO_0055085 transmembrane transport http://purl.obolibrary.org/obo/GO_0044763 single-organism cellular process http://purl.obolibrary.org/obo/GO_0006836 neurotransmitter transport http://purl.obolibrary.org/obo/GO_0044765 single-organism transport http://purl.obolibrary.org/obo/GO_0009914 hormone transport http://purl.obolibrary.org/obo/GO_0010817 regulation of hormone levels http://purl.obolibrary.org/obo/GO_0046903 secretion http://purl.obolibrary.org/obo/GO_0044765 single-organism transport http://purl.obolibrary.org/obo/GO_0045276 plasma membrane respiratory chain complex III http://purl.obolibrary.org/obo/GO_0044459 plasma membrane part http://purl.obolibrary.org/obo/GO_0045860 positive regulation of protein kinase activity http://purl.obolibrary.org/obo/GO_0033674 positive regulation of kinase activity http://purl.obolibrary.org/obo/GO_0061097 regulation of protein tyrosine kinase activity http://purl.obolibrary.org/obo/GO_0050730 regulation of peptidyl-tyrosine phosphorylation http://purl.obolibrary.org/obo/GO_0071900 regulation of protein serine/threonine kinase activity http://purl.obolibrary.org/obo/GO_0045859 regulation of protein kinase activity http://purl.obolibrary.org/obo/GO_0071902 positive regulation of protein serine/threonine kinase activity http://purl.obolibrary.org/obo/GO_0071900 regulation of protein serine/threonine kinase activity http://purl.obolibrary.org/obo/GO_0061098 positive regulation of protein tyrosine kinase activity http://purl.obolibrary.org/obo/GO_0050731 positive regulation of peptidyl-tyrosine phosphorylation http://purl.obolibrary.org/obo/GO_1901073 glucosamine-containing compound biosynthetic process http://purl.obolibrary.org/obo/GO_1901071 glucosamine-containing compound metabolic process http://purl.obolibrary.org/obo/GO_0046854 phosphatidylinositol phosphorylation http://purl.obolibrary.org/obo/GO_0046834 lipid phosphorylation http://purl.obolibrary.org/obo/GO_0035251 UDP-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0008194 UDP-glycosyltransferase activity http://purl.obolibrary.org/obo/GO_0046887 positive regulation of hormone secretion http://purl.obolibrary.org/obo/GO_0048522 positive regulation of cellular process http://purl.obolibrary.org/obo/GO_0090276 regulation of peptide hormone secretion http://purl.obolibrary.org/obo/GO_0002791 regulation of peptide secretion http://purl.obolibrary.org/obo/GO_0046889 positive regulation of lipid biosynthetic process http://purl.obolibrary.org/obo/GO_0009891 positive regulation of biosynthetic process http://purl.obolibrary.org/obo/GO_0008137 NADH dehydrogenase (ubiquinone) activity http://purl.obolibrary.org/obo/GO_0050136 NADH dehydrogenase (quinone) activity http://purl.obolibrary.org/obo/GO_0051716 cellular response to stimulus http://purl.obolibrary.org/obo/GO_0044763 single-organism cellular process http://purl.obolibrary.org/obo/GO_0006950 response to stress http://purl.obolibrary.org/obo/GO_0050896 response to stimulus http://purl.obolibrary.org/obo/GO_0009605 response to external stimulus http://purl.obolibrary.org/obo/GO_0050896 response to stimulus http://purl.obolibrary.org/obo/GO_0042221 response to chemical http://purl.obolibrary.org/obo/GO_0050896 response to stimulus http://purl.obolibrary.org/obo/GO_0009719 response to endogenous stimulus http://purl.obolibrary.org/obo/GO_0050896 response to stimulus http://purl.obolibrary.org/obo/GO_0051606 detection of stimulus http://purl.obolibrary.org/obo/GO_0050896 response to stimulus http://purl.obolibrary.org/obo/GO_0051649 establishment of localization in cell http://purl.obolibrary.org/obo/GO_0051234 establishment of localization http://purl.obolibrary.org/obo/GO_0030243 cellulose metabolic process http://purl.obolibrary.org/obo/GO_0051273 beta-glucan metabolic process http://purl.obolibrary.org/obo/GO_0030244 cellulose biosynthetic process http://purl.obolibrary.org/obo/GO_0030243 cellulose metabolic process http://purl.obolibrary.org/obo/GO_0035257 nuclear hormone receptor binding http://purl.obolibrary.org/obo/GO_0051427 hormone receptor binding http://purl.obolibrary.org/obo/GO_0032940 secretion by cell http://purl.obolibrary.org/obo/GO_0046903 secretion http://purl.obolibrary.org/obo/GO_0007165 signal transduction http://purl.obolibrary.org/obo/GO_0050794 regulation of cellular process http://purl.obolibrary.org/obo/GO_0070887 cellular response to chemical stimulus http://purl.obolibrary.org/obo/GO_0042221 response to chemical http://purl.obolibrary.org/obo/GO_0009116 nucleoside metabolic process http://purl.obolibrary.org/obo/GO_1901657 glycosyl compound metabolic process http://purl.obolibrary.org/obo/GO_0004871 signal transducer activity http://purl.obolibrary.org/obo/GO_0060089 molecular transducer activity http://purl.obolibrary.org/obo/GO_0070470 plasma membrane respiratory chain http://purl.obolibrary.org/obo/GO_0044459 plasma membrane part http://purl.obolibrary.org/obo/GO_0006816 calcium ion transport http://purl.obolibrary.org/obo/GO_0070838 divalent metal ion transport http://purl.obolibrary.org/obo/GO_0043170 macromolecule metabolic process http://purl.obolibrary.org/obo/GO_0071704 organic substance metabolic process http://purl.obolibrary.org/obo/GO_1901135 carbohydrate derivative metabolic process http://purl.obolibrary.org/obo/GO_0071704 organic substance metabolic process http://purl.obolibrary.org/obo/GO_1901575 organic substance catabolic process http://purl.obolibrary.org/obo/GO_0009056 catabolic process http://purl.obolibrary.org/obo/GO_1901576 organic substance biosynthetic process http://purl.obolibrary.org/obo/GO_0009058 biosynthetic process http://purl.obolibrary.org/obo/GO_1901615 organic hydroxy compound metabolic process http://purl.obolibrary.org/obo/GO_0071704 organic substance metabolic process http://purl.obolibrary.org/obo/GO_1901360 organic cyclic compound metabolic process http://purl.obolibrary.org/obo/GO_0071704 organic substance metabolic process http://purl.obolibrary.org/obo/GO_0015085 calcium ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0046873 metal ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0070838 divalent metal ion transport http://purl.obolibrary.org/obo/GO_0030001 metal ion transport http://purl.obolibrary.org/obo/GO_0019219 regulation of nucleobase-containing compound metabolic process http://purl.obolibrary.org/obo/GO_0051171 regulation of nitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_0019216 regulation of lipid metabolic process http://purl.obolibrary.org/obo/GO_0080090 regulation of primary metabolic process http://purl.obolibrary.org/obo/GO_0051246 regulation of protein metabolic process http://purl.obolibrary.org/obo/GO_0060255 regulation of macromolecule metabolic process http://purl.obolibrary.org/obo/GO_0090305 nucleic acid phosphodiester bond hydrolysis http://purl.obolibrary.org/obo/GO_0090304 nucleic acid metabolic process http://purl.obolibrary.org/obo/GO_0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity http://purl.obolibrary.org/obo/GO_0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity http://purl.obolibrary.org/obo/GO_1901136 carbohydrate derivative catabolic process http://purl.obolibrary.org/obo/GO_1901575 organic substance catabolic process http://purl.obolibrary.org/obo/GO_1901137 carbohydrate derivative biosynthetic process http://purl.obolibrary.org/obo/GO_1901576 organic substance biosynthetic process http://purl.obolibrary.org/obo/GO_1901361 organic cyclic compound catabolic process http://purl.obolibrary.org/obo/GO_1901360 organic cyclic compound metabolic process http://purl.obolibrary.org/obo/GO_1901565 organonitrogen compound catabolic process http://purl.obolibrary.org/obo/GO_1901564 organonitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_1901658 glycosyl compound catabolic process http://purl.obolibrary.org/obo/GO_1901657 glycosyl compound metabolic process http://purl.obolibrary.org/obo/GO_1901617 organic hydroxy compound biosynthetic process http://purl.obolibrary.org/obo/GO_1901615 organic hydroxy compound metabolic process http://purl.obolibrary.org/obo/GO_1901362 organic cyclic compound biosynthetic process http://purl.obolibrary.org/obo/GO_1901360 organic cyclic compound metabolic process http://purl.obolibrary.org/obo/GO_1901566 organonitrogen compound biosynthetic process http://purl.obolibrary.org/obo/GO_1901564 organonitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_0010962 regulation of glucan biosynthetic process http://purl.obolibrary.org/obo/GO_0032885 regulation of polysaccharide biosynthetic process http://purl.obolibrary.org/obo/GO_0006355 regulation of transcription, DNA-dependent http://purl.obolibrary.org/obo/GO_2001141 regulation of RNA biosynthetic process http://purl.obolibrary.org/obo/GO_2000278 regulation of DNA biosynthetic process http://purl.obolibrary.org/obo/GO_0051052 regulation of DNA metabolic process http://purl.obolibrary.org/obo/GO_0090218 positive regulation of lipid kinase activity http://purl.obolibrary.org/obo/GO_0043550 regulation of lipid kinase activity http://purl.obolibrary.org/obo/GO_0048023 positive regulation of melanin biosynthetic process http://purl.obolibrary.org/obo/GO_1900378 positive regulation of secondary metabolite biosynthetic process http://purl.obolibrary.org/obo/GO_0048386 positive regulation of retinoic acid receptor signaling pathway http://purl.obolibrary.org/obo/GO_0009967 positive regulation of signal transduction http://purl.obolibrary.org/obo/GO_0050907 detection of chemical stimulus involved in sensory perception http://purl.obolibrary.org/obo/GO_0009593 detection of chemical stimulus http://purl.obolibrary.org/obo/GO_0050911 detection of chemical stimulus involved in sensory perception of smell http://purl.obolibrary.org/obo/GO_0050907 detection of chemical stimulus involved in sensory perception http://purl.obolibrary.org/obo/GO_0051006 positive regulation of lipoprotein lipase activity http://purl.obolibrary.org/obo/GO_0061365 positive regulation of triglyceride lipase activity http://purl.obolibrary.org/obo/GO_0032516 positive regulation of phosphoprotein phosphatase activity http://purl.obolibrary.org/obo/GO_0010922 positive regulation of phosphatase activity http://purl.obolibrary.org/obo/GO_0071385 cellular response to glucocorticoid stimulus http://purl.obolibrary.org/obo/GO_0071384 cellular response to corticosteroid stimulus http://purl.obolibrary.org/obo/GO_0051582 positive regulation of neurotransmitter uptake http://purl.obolibrary.org/obo/GO_0051590 positive regulation of neurotransmitter transport http://purl.obolibrary.org/obo/GO_0051611 regulation of serotonin uptake http://purl.obolibrary.org/obo/GO_0043269 regulation of ion transport http://purl.obolibrary.org/obo/GO_0051940 regulation of catecholamine uptake involved in synaptic transmission http://purl.obolibrary.org/obo/GO_0051952 regulation of amine transport http://purl.obolibrary.org/obo/GO_0051613 positive regulation of serotonin uptake http://purl.obolibrary.org/obo/GO_0043270 positive regulation of ion transport http://purl.obolibrary.org/obo/GO_0051944 positive regulation of catecholamine uptake involved in synaptic transmission http://purl.obolibrary.org/obo/GO_0051954 positive regulation of amine transport http://purl.obolibrary.org/obo/GO_0051586 positive regulation of dopamine uptake involved in synaptic transmission http://purl.obolibrary.org/obo/GO_0043270 positive regulation of ion transport http://purl.obolibrary.org/obo/GO_0051580 regulation of neurotransmitter uptake http://purl.obolibrary.org/obo/GO_0050804 regulation of synaptic transmission http://purl.obolibrary.org/obo/GO_0051590 positive regulation of neurotransmitter transport http://purl.obolibrary.org/obo/GO_0051050 positive regulation of transport http://purl.obolibrary.org/obo/GO_0051668 localization within membrane http://purl.obolibrary.org/obo/GO_0051641 cellular localization http://purl.obolibrary.org/obo/GO_0051583 dopamine uptake involved in synaptic transmission http://purl.obolibrary.org/obo/GO_0090494 dopamine uptake http://purl.obolibrary.org/obo/GO_0051584 regulation of dopamine uptake involved in synaptic transmission http://purl.obolibrary.org/obo/GO_0043269 regulation of ion transport http://purl.obolibrary.org/obo/GO_0050789 regulation of biological process http://purl.obolibrary.org/obo/GO_0065007 biological regulation http://purl.obolibrary.org/obo/GO_0065008 regulation of biological quality http://purl.obolibrary.org/obo/GO_0065007 biological regulation http://purl.obolibrary.org/obo/GO_0065009 regulation of molecular function http://purl.obolibrary.org/obo/GO_0065007 biological regulation http://purl.obolibrary.org/obo/GO_0051934 catecholamine uptake involved in synaptic transmission http://purl.obolibrary.org/obo/GO_0001504 neurotransmitter uptake http://purl.obolibrary.org/obo/GO_0090494 dopamine uptake http://purl.obolibrary.org/obo/GO_0015872 dopamine transport http://purl.obolibrary.org/obo/CHEBI_35211 radioactive label http://purl.obolibrary.org/obo/CHEBI_35209 label http://purl.obolibrary.org/obo/MP_0011672 unbalanced complete atrioventricular canal, left dominant http://purl.obolibrary.org/obo/MP_0011673 unbalanced complete common atrioventricular canal http://purl.obolibrary.org/obo/MP_0011714 increased circulating interleukin-8 level http://purl.obolibrary.org/obo/MP_0011713 abnormal circulating interleukin-8 level http://purl.obolibrary.org/obo/MP_0011715 decreased circulating interleukin-8 level http://purl.obolibrary.org/obo/MP_0011713 abnormal circulating interleukin-8 level http://purl.obolibrary.org/obo/MP_0011717 increased interleukin-8 secretion http://purl.obolibrary.org/obo/MP_0011716 abnormal interleukin-8 secretion http://purl.obolibrary.org/obo/MP_0011718 decreased interleukin-8 secretion http://purl.obolibrary.org/obo/MP_0011716 abnormal interleukin-8 secretion http://purl.obolibrary.org/obo/MP_0012633 increased phospholipase A2 level http://purl.obolibrary.org/obo/MP_0012044 abnormal phospholipase A2 level http://purl.obolibrary.org/obo/MP_0012634 decreased phospholipase A2 level http://purl.obolibrary.org/obo/MP_0012044 abnormal phospholipase A2 level http://purl.obolibrary.org/obo/MP_0012116 increased trophectoderm cell proliferation http://purl.obolibrary.org/obo/MP_0012115 abnormal trophectoderm cell proliferation http://purl.obolibrary.org/obo/MP_0012117 decreased trophectoderm cell proliferation http://purl.obolibrary.org/obo/MP_0012115 abnormal trophectoderm cell proliferation http://purl.obolibrary.org/obo/MP_0012118 absent trophectoderm cell proliferation http://purl.obolibrary.org/obo/MP_0012115 abnormal trophectoderm cell proliferation http://purl.obolibrary.org/obo/MP_0012231 abnormal ganglioside level http://purl.obolibrary.org/obo/MP_0012232 abnormal ceramide level http://purl.obolibrary.org/obo/MP_0012229 abnormal sulfoglycosphingolipid level http://purl.obolibrary.org/obo/MP_0012233 abnormal acidic glycosphingolipid level http://purl.obolibrary.org/obo/MP_0012601 decreased alpha-fetoprotein level http://purl.obolibrary.org/obo/MP_0012600 abnormal alpha-fetoprotein level http://purl.obolibrary.org/obo/MP_0012602 increased alpha-fetoprotein level http://purl.obolibrary.org/obo/MP_0012600 abnormal alpha-fetoprotein level http://purl.obolibrary.org/obo/MP_0012604 decreased glutathione level http://purl.obolibrary.org/obo/MP_0012603 abnormal glutathione level http://purl.obolibrary.org/obo/MP_0012606 increased glutathione level http://purl.obolibrary.org/obo/MP_0012603 abnormal glutathione level http://purl.obolibrary.org/obo/MP_0012605 decreased kidney glutathione level http://purl.obolibrary.org/obo/MP_0012604 decreased glutathione level http://purl.obolibrary.org/obo/MP_0012607 increased kidney glutathione level http://purl.obolibrary.org/obo/MP_0012606 increased glutathione level http://purl.obolibrary.org/obo/MP_0012609 decreased complement C5 level http://purl.obolibrary.org/obo/MP_0012608 abnormal complement C5 level http://purl.obolibrary.org/obo/MP_0012610 increased complement C5 level http://purl.obolibrary.org/obo/MP_0012608 abnormal complement C5 level http://purl.obolibrary.org/obo/MP_0012612 decreased ceruloplasmin level http://purl.obolibrary.org/obo/MP_0012611 abnormal ceruloplasmin level http://purl.obolibrary.org/obo/MP_0012613 increased ceruloplasmin level http://purl.obolibrary.org/obo/MP_0012611 abnormal ceruloplasmin level http://purl.obolibrary.org/obo/MP_0012615 decreased circulating factor IX level http://purl.obolibrary.org/obo/MP_0012614 abnormal circulating factor IX level http://purl.obolibrary.org/obo/MP_0012616 increased circulating factor IX level http://purl.obolibrary.org/obo/MP_0012614 abnormal circulating factor IX level http://purl.obolibrary.org/obo/MP_0012618 decreased circulating factor X level http://purl.obolibrary.org/obo/MP_0012617 abnormal circulating factor X level http://purl.obolibrary.org/obo/MP_0012619 increased circulating factor X level http://purl.obolibrary.org/obo/MP_0012617 abnormal circulating factor X level http://purl.obolibrary.org/obo/MP_0012621 decreased circulating factor XIII level http://purl.obolibrary.org/obo/MP_0012620 abnormal circulating factor XIII level http://purl.obolibrary.org/obo/MP_0012622 increased circulating factor XIII level http://purl.obolibrary.org/obo/MP_0012620 abnormal circulating factor XIII level http://purl.obolibrary.org/obo/MP_0012629 decreased glutathione reductase level http://purl.obolibrary.org/obo/MP_0012628 abnormal glutathione reductase level http://purl.obolibrary.org/obo/MP_0012630 increased glutathione reductase level http://purl.obolibrary.org/obo/MP_0012628 abnormal glutathione reductase level http://purl.obolibrary.org/obo/MP_0012631 decreased kidney glutathione reductase level http://purl.obolibrary.org/obo/MP_0012629 decreased glutathione reductase level http://purl.obolibrary.org/obo/MP_0012632 increased kidney glutathione reductase level http://purl.obolibrary.org/obo/MP_0012630 increased glutathione reductase level http://purl.obolibrary.org/obo/MP_0012641 decreased benz (alpha) pyrene hydroxylase activity http://purl.obolibrary.org/obo/MP_0012640 abnormal benz (alpha) pyrene hydroxylase activity http://purl.obolibrary.org/obo/MP_0012642 increased benz (alpha) pyrene hydroxylase activity http://purl.obolibrary.org/obo/MP_0012640 abnormal benz (alpha) pyrene hydroxylase activity http://purl.obolibrary.org/obo/MP_0012647 decreased urokinase activity http://purl.obolibrary.org/obo/MP_0012646 abnormal urokinase activity http://purl.obolibrary.org/obo/MP_0012648 increased urokinase activity http://purl.obolibrary.org/obo/MP_0012646 abnormal urokinase activity http://purl.obolibrary.org/obo/MP_0012650 abnormal erythrocyte catalase level http://purl.obolibrary.org/obo/MP_0012649 abnormal catalase level http://purl.obolibrary.org/obo/MP_0012651 abnormal kidney catalase level http://purl.obolibrary.org/obo/MP_0012649 abnormal catalase level http://purl.obolibrary.org/obo/MP_0012652 decreased catalase level http://purl.obolibrary.org/obo/MP_0012649 abnormal catalase level http://purl.obolibrary.org/obo/MP_0012655 increased catalase level http://purl.obolibrary.org/obo/MP_0012649 abnormal catalase level http://purl.obolibrary.org/obo/MP_0012653 decreased erythrocyte catalase level http://purl.obolibrary.org/obo/MP_0012652 decreased catalase level http://purl.obolibrary.org/obo/MP_0012656 increased erythrocyte catalase level http://purl.obolibrary.org/obo/MP_0012655 increased catalase level http://purl.obolibrary.org/obo/MP_0012654 decreased kidney catalase level http://purl.obolibrary.org/obo/MP_0012652 decreased catalase level http://purl.obolibrary.org/obo/MP_0012657 increased kidney catalase level http://purl.obolibrary.org/obo/MP_0012655 increased catalase level http://purl.obolibrary.org/obo/MP_0012659 decreased superoxide dismutase level http://purl.obolibrary.org/obo/MP_0012658 abnormal superoxide dismutase level http://purl.obolibrary.org/obo/MP_0012660 increased superoxide dismutase level http://purl.obolibrary.org/obo/MP_0012658 abnormal superoxide dismutase level http://purl.obolibrary.org/obo/MP_0013408 abnormal dendritic epidermal T cell number http://purl.obolibrary.org/obo/MP_0013407 abnormal dendritic epidermal T cell morphology http://purl.obolibrary.org/obo/MP_0013409 increased dendritic epidermal T cell number http://purl.obolibrary.org/obo/MP_0013408 abnormal dendritic epidermal T cell number http://purl.obolibrary.org/obo/MP_0013410 decreased dendritic epidermal T cell number http://purl.obolibrary.org/obo/MP_0013408 abnormal dendritic epidermal T cell number http://purl.obolibrary.org/obo/GO_0006390 transcription from mitochondrial promoter http://purl.obolibrary.org/obo/GO_0044711 single-organism biosynthetic process http://purl.obolibrary.org/obo/GO_0044212 transcription regulatory region DNA binding http://purl.obolibrary.org/obo/GO_0000975 regulatory region DNA binding http://purl.obolibrary.org/obo/GO_0000977 RNA polymerase II regulatory region sequence-specific DNA binding http://purl.obolibrary.org/obo/GO_0001012 RNA polymerase II regulatory region DNA binding http://purl.obolibrary.org/obo/GO_0000975 regulatory region DNA binding http://purl.obolibrary.org/obo/GO_0003677 DNA binding http://purl.obolibrary.org/obo/GO_0003700 sequence-specific DNA binding transcription factor activity http://purl.obolibrary.org/obo/GO_0001071 nucleic acid binding transcription factor activity http://purl.obolibrary.org/obo/GO_0051610 serotonin uptake http://purl.obolibrary.org/obo/GO_0006837 serotonin transport http://purl.obolibrary.org/obo/GO_0001504 neurotransmitter uptake http://purl.obolibrary.org/obo/GO_0006836 neurotransmitter transport http://purl.obolibrary.org/obo/GO_0060055 angiogenesis involved in wound healing http://purl.obolibrary.org/obo/GO_0001525 angiogenesis http://purl.obolibrary.org/obo/GO_0008528 G-protein coupled peptide receptor activity http://purl.obolibrary.org/obo/GO_0004930 G-protein coupled receptor activity http://purl.obolibrary.org/obo/GO_0031628 opioid receptor binding http://purl.obolibrary.org/obo/GO_0001664 G-protein coupled receptor binding http://purl.obolibrary.org/obo/GO_0031690 adrenergic receptor binding http://purl.obolibrary.org/obo/GO_0001664 G-protein coupled receptor binding http://purl.obolibrary.org/obo/GO_0035256 G-protein coupled glutamate receptor binding http://purl.obolibrary.org/obo/GO_0035254 glutamate receptor binding http://purl.obolibrary.org/obo/GO_0045321 leukocyte activation http://purl.obolibrary.org/obo/GO_0002376 immune system process http://purl.obolibrary.org/obo/GO_0030168 platelet activation http://purl.obolibrary.org/obo/GO_0001775 cell activation http://purl.obolibrary.org/obo/GO_0045859 regulation of protein kinase activity http://purl.obolibrary.org/obo/GO_0043549 regulation of kinase activity http://purl.obolibrary.org/obo/GO_0001934 positive regulation of protein phosphorylation http://purl.obolibrary.org/obo/GO_0042327 positive regulation of phosphorylation http://purl.obolibrary.org/obo/GO_0050730 regulation of peptidyl-tyrosine phosphorylation http://purl.obolibrary.org/obo/GO_0001932 regulation of protein phosphorylation http://purl.obolibrary.org/obo/GO_0050731 positive regulation of peptidyl-tyrosine phosphorylation http://purl.obolibrary.org/obo/GO_0050730 regulation of peptidyl-tyrosine phosphorylation http://purl.obolibrary.org/obo/GO_0001961 positive regulation of cytokine-mediated signaling pathway http://purl.obolibrary.org/obo/GO_0060760 positive regulation of response to cytokine stimulus http://purl.obolibrary.org/obo/GO_0010765 positive regulation of sodium ion transport http://purl.obolibrary.org/obo/GO_0043270 positive regulation of ion transport http://purl.obolibrary.org/obo/GO_0002684 positive regulation of immune system process http://purl.obolibrary.org/obo/GO_0048518 positive regulation of biological process http://purl.obolibrary.org/obo/GO_0002694 regulation of leukocyte activation http://purl.obolibrary.org/obo/GO_0050865 regulation of cell activation http://purl.obolibrary.org/obo/GO_0002696 positive regulation of leukocyte activation http://purl.obolibrary.org/obo/GO_0050867 positive regulation of cell activation http://purl.obolibrary.org/obo/GO_0051249 regulation of lymphocyte activation http://purl.obolibrary.org/obo/GO_0002694 regulation of leukocyte activation http://purl.obolibrary.org/obo/GO_0051251 positive regulation of lymphocyte activation http://purl.obolibrary.org/obo/GO_0051249 regulation of lymphocyte activation http://purl.obolibrary.org/obo/GO_0030072 peptide hormone secretion http://purl.obolibrary.org/obo/GO_0046879 hormone secretion http://purl.obolibrary.org/obo/GO_0002793 positive regulation of peptide secretion http://purl.obolibrary.org/obo/GO_0051047 positive regulation of secretion http://purl.obolibrary.org/obo/GO_0090277 positive regulation of peptide hormone secretion http://purl.obolibrary.org/obo/GO_0090276 regulation of peptide hormone secretion http://purl.obolibrary.org/obo/GO_0050877 neurological system process http://purl.obolibrary.org/obo/GO_0003008 system process http://purl.obolibrary.org/obo/GO_0060089 molecular transducer activity http://purl.obolibrary.org/obo/GO_0003674 molecular_function http://purl.obolibrary.org/obo/GO_0001071 nucleic acid binding transcription factor activity http://purl.obolibrary.org/obo/GO_0003674 molecular_function http://purl.obolibrary.org/obo/GO_0003824 catalytic activity http://purl.obolibrary.org/obo/GO_0003674 molecular_function http://purl.obolibrary.org/obo/GO_0004872 receptor activity http://purl.obolibrary.org/obo/GO_0003674 molecular_function http://purl.obolibrary.org/obo/GO_0005488 binding http://purl.obolibrary.org/obo/GO_0003674 molecular_function http://purl.obolibrary.org/obo/GO_0030545 receptor regulator activity http://purl.obolibrary.org/obo/GO_0003674 molecular_function http://purl.obolibrary.org/obo/GO_0001067 regulatory region nucleic acid binding http://purl.obolibrary.org/obo/GO_0003676 nucleic acid binding http://purl.obolibrary.org/obo/GO_0003677 DNA binding http://purl.obolibrary.org/obo/GO_0003676 nucleic acid binding http://purl.obolibrary.org/obo/GO_0043565 sequence-specific DNA binding http://purl.obolibrary.org/obo/GO_0003677 DNA binding http://purl.obolibrary.org/obo/GO_0098531 direct ligand regulated sequence-specific DNA binding transcription factor activity http://purl.obolibrary.org/obo/GO_0003700 sequence-specific DNA binding transcription factor activity http://purl.obolibrary.org/obo/GO_0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity http://purl.obolibrary.org/obo/GO_0003700 sequence-specific DNA binding transcription factor activity http://purl.obolibrary.org/obo/GO_0030284 estrogen receptor activity http://purl.obolibrary.org/obo/GO_0003707 steroid hormone receptor activity http://purl.obolibrary.org/obo/GO_0016491 oxidoreductase activity http://purl.obolibrary.org/obo/GO_0003824 catalytic activity http://purl.obolibrary.org/obo/GO_0016740 transferase activity http://purl.obolibrary.org/obo/GO_0003824 catalytic activity http://purl.obolibrary.org/obo/GO_0016787 hydrolase activity http://purl.obolibrary.org/obo/GO_0003824 catalytic activity http://purl.obolibrary.org/obo/GO_0016829 lyase activity http://purl.obolibrary.org/obo/GO_0003824 catalytic activity http://purl.obolibrary.org/obo/GO_0016853 isomerase activity http://purl.obolibrary.org/obo/GO_0003824 catalytic activity http://purl.obolibrary.org/obo/GO_0016874 ligase activity http://purl.obolibrary.org/obo/GO_0003824 catalytic activity http://purl.obolibrary.org/obo/GO_0019239 deaminase activity http://purl.obolibrary.org/obo/GO_0003824 catalytic activity http://purl.obolibrary.org/obo/GO_0061505 DNA topoisomerase II activity http://purl.obolibrary.org/obo/GO_0003916 DNA topoisomerase activity http://purl.obolibrary.org/obo/GO_0050136 NADH dehydrogenase (quinone) activity http://purl.obolibrary.org/obo/GO_0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor http://purl.obolibrary.org/obo/GO_0008106 alcohol dehydrogenase (NADP+) activity http://purl.obolibrary.org/obo/GO_0004033 aldo-keto reductase (NADP) activity http://purl.obolibrary.org/obo/GO_0003990 acetylcholinesterase activity http://purl.obolibrary.org/obo/GO_0004104 cholinesterase activity http://purl.obolibrary.org/obo/GO_0004222 metalloendopeptidase activity http://purl.obolibrary.org/obo/GO_0008237 metallopeptidase activity http://purl.obolibrary.org/obo/GO_0004252 serine-type endopeptidase activity http://purl.obolibrary.org/obo/GO_0008236 serine-type peptidase activity http://purl.obolibrary.org/obo/GO_0016160 amylase activity http://purl.obolibrary.org/obo/GO_0004553 hydrolase activity, hydrolyzing O-glycosyl compounds http://purl.obolibrary.org/obo/GO_0015926 glucosidase activity http://purl.obolibrary.org/obo/GO_0004553 hydrolase activity, hydrolyzing O-glycosyl compounds http://purl.obolibrary.org/obo/GO_0016997 alpha-sialidase activity http://purl.obolibrary.org/obo/GO_0004553 hydrolase activity, hydrolyzing O-glycosyl compounds http://purl.obolibrary.org/obo/GO_0030305 heparanase activity http://purl.obolibrary.org/obo/GO_0004553 hydrolase activity, hydrolyzing O-glycosyl compounds http://purl.obolibrary.org/obo/GO_0004435 phosphatidylinositol phospholipase C activity http://purl.obolibrary.org/obo/GO_0004629 phospholipase C activity http://purl.obolibrary.org/obo/GO_0008318 protein prenyltransferase activity http://purl.obolibrary.org/obo/GO_0004659 prenyltransferase activity http://purl.obolibrary.org/obo/GO_0004337 geranyltranstransferase activity http://purl.obolibrary.org/obo/GO_0004659 prenyltransferase activity http://purl.obolibrary.org/obo/GO_0004465 lipoprotein lipase activity http://purl.obolibrary.org/obo/GO_0004806 triglyceride lipase activity http://purl.obolibrary.org/obo/GO_0038023 signaling receptor activity http://purl.obolibrary.org/obo/GO_0004872 receptor activity http://purl.obolibrary.org/obo/GO_0003708 retinoic acid receptor activity http://purl.obolibrary.org/obo/GO_0038023 signaling receptor activity http://purl.obolibrary.org/obo/GO_0008066 glutamate receptor activity http://purl.obolibrary.org/obo/GO_0004888 transmembrane signaling receptor activity http://purl.obolibrary.org/obo/GO_0004896 cytokine receptor activity http://purl.obolibrary.org/obo/GO_0004888 transmembrane signaling receptor activity http://purl.obolibrary.org/obo/GO_0004930 G-protein coupled receptor activity http://purl.obolibrary.org/obo/GO_0004888 transmembrane signaling receptor activity http://purl.obolibrary.org/obo/GO_0016500 protein-hormone receptor activity http://purl.obolibrary.org/obo/GO_0004930 G-protein coupled receptor activity http://purl.obolibrary.org/obo/GO_0045125 bioactive lipid receptor activity http://purl.obolibrary.org/obo/GO_0004930 G-protein coupled receptor activity http://purl.obolibrary.org/obo/GO_0051427 hormone receptor binding http://purl.obolibrary.org/obo/GO_0005102 receptor binding http://purl.obolibrary.org/obo/GO_0001664 G-protein coupled receptor binding http://purl.obolibrary.org/obo/GO_0005102 receptor binding http://purl.obolibrary.org/obo/GO_0005186 pheromone activity http://purl.obolibrary.org/obo/GO_0005102 receptor binding http://purl.obolibrary.org/obo/GO_0035254 glutamate receptor binding http://purl.obolibrary.org/obo/GO_0005102 receptor binding http://purl.obolibrary.org/obo/GO_0033218 amide binding http://purl.obolibrary.org/obo/GO_0005488 binding http://purl.obolibrary.org/obo/GO_0042562 hormone binding http://purl.obolibrary.org/obo/GO_0005488 binding http://purl.obolibrary.org/obo/GO_1901567 fatty acid derivative binding http://purl.obolibrary.org/obo/GO_0005488 binding http://purl.obolibrary.org/obo/GO_0005515 protein binding http://purl.obolibrary.org/obo/GO_0005488 binding http://purl.obolibrary.org/obo/GO_0008289 lipid binding http://purl.obolibrary.org/obo/GO_0005488 binding http://purl.obolibrary.org/obo/GO_0036094 small molecule binding http://purl.obolibrary.org/obo/GO_0005488 binding http://purl.obolibrary.org/obo/GO_0097159 organic cyclic compound binding http://purl.obolibrary.org/obo/GO_0005488 binding http://purl.obolibrary.org/obo/GO_1901363 heterocyclic compound binding http://purl.obolibrary.org/obo/GO_0005488 binding http://purl.obolibrary.org/obo/GO_0043167 ion binding http://purl.obolibrary.org/obo/GO_0005488 binding http://purl.obolibrary.org/obo/GO_0001972 retinoic acid binding http://purl.obolibrary.org/obo/GO_0033293 monocarboxylic acid binding http://purl.obolibrary.org/obo/GO_0019838 growth factor binding http://purl.obolibrary.org/obo/GO_0005515 protein binding http://purl.obolibrary.org/obo/GO_0005102 receptor binding http://purl.obolibrary.org/obo/GO_0005515 protein binding http://purl.obolibrary.org/obo/GO_0008134 transcription factor binding http://purl.obolibrary.org/obo/GO_0005515 protein binding http://purl.obolibrary.org/obo/GO_0019955 cytokine binding http://purl.obolibrary.org/obo/GO_0005515 protein binding http://purl.obolibrary.org/obo/GO_0044042 glucan metabolic process http://purl.obolibrary.org/obo/GO_0005976 polysaccharide metabolic process http://purl.obolibrary.org/obo/GO_0000271 polysaccharide biosynthetic process http://purl.obolibrary.org/obo/GO_0016051 carbohydrate biosynthetic process http://purl.obolibrary.org/obo/GO_0032042 mitochondrial DNA metabolic process http://purl.obolibrary.org/obo/GO_0006259 DNA metabolic process http://purl.obolibrary.org/obo/GO_0006278 RNA-dependent DNA replication http://purl.obolibrary.org/obo/GO_0006260 DNA replication http://purl.obolibrary.org/obo/GO_0034401 regulation of transcription by chromatin organization http://purl.obolibrary.org/obo/GO_0006355 regulation of transcription, DNA-dependent http://purl.obolibrary.org/obo/GO_0016568 chromatin modification http://purl.obolibrary.org/obo/GO_0006325 chromatin organization http://purl.obolibrary.org/obo/GO_0006366 transcription from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0006351 transcription, DNA-templated http://purl.obolibrary.org/obo/GO_0006357 regulation of transcription from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0006355 regulation of transcription, DNA-dependent http://purl.obolibrary.org/obo/GO_0045893 positive regulation of transcription, DNA-dependent http://purl.obolibrary.org/obo/GO_0010628 positive regulation of gene expression http://purl.obolibrary.org/obo/GO_0051090 regulation of sequence-specific DNA binding transcription factor activity http://purl.obolibrary.org/obo/GO_0065009 regulation of molecular function http://purl.obolibrary.org/obo/GO_0045944 positive regulation of transcription from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0045893 positive regulation of transcription, DNA-dependent http://purl.obolibrary.org/obo/GO_0032543 mitochondrial translation http://purl.obolibrary.org/obo/GO_0044711 single-organism biosynthetic process http://purl.obolibrary.org/obo/GO_0035601 protein deacylation http://purl.obolibrary.org/obo/GO_0006464 cellular protein modification process http://purl.obolibrary.org/obo/GO_0018193 peptidyl-amino acid modification http://purl.obolibrary.org/obo/GO_0006464 cellular protein modification process http://purl.obolibrary.org/obo/GO_0008652 cellular amino acid biosynthetic process http://purl.obolibrary.org/obo/GO_1901566 organonitrogen compound biosynthetic process http://purl.obolibrary.org/obo/GO_1901605 alpha-amino acid metabolic process http://purl.obolibrary.org/obo/GO_0006520 cellular amino acid metabolic process http://purl.obolibrary.org/obo/GO_0045764 positive regulation of cellular amino acid metabolic process http://purl.obolibrary.org/obo/GO_0033240 positive regulation of cellular amine metabolic process http://purl.obolibrary.org/obo/GO_0090357 regulation of tryptophan metabolic process http://purl.obolibrary.org/obo/GO_0006521 regulation of cellular amino acid metabolic process http://purl.obolibrary.org/obo/GO_2000282 regulation of cellular amino acid biosynthetic process http://purl.obolibrary.org/obo/GO_0031326 regulation of cellular biosynthetic process http://purl.obolibrary.org/obo/GO_0000162 tryptophan biosynthetic process http://purl.obolibrary.org/obo/GO_1901607 alpha-amino acid biosynthetic process http://purl.obolibrary.org/obo/GO_0042401 cellular biogenic amine biosynthetic process http://purl.obolibrary.org/obo/GO_0009309 amine biosynthetic process http://purl.obolibrary.org/obo/GO_0035725 sodium ion transmembrane transport http://purl.obolibrary.org/obo/GO_0034220 ion transmembrane transport http://purl.obolibrary.org/obo/GO_0070588 calcium ion transmembrane transport http://purl.obolibrary.org/obo/GO_0034220 ion transmembrane transport http://purl.obolibrary.org/obo/GO_0009611 response to wounding http://purl.obolibrary.org/obo/GO_0006950 response to stress http://purl.obolibrary.org/obo/GO_0000002 mitochondrial genome maintenance http://purl.obolibrary.org/obo/GO_0007005 mitochondrion organization http://purl.obolibrary.org/obo/GO_0016337 cell-cell adhesion http://purl.obolibrary.org/obo/GO_0007155 cell adhesion http://purl.obolibrary.org/obo/GO_0007166 cell surface receptor signaling pathway http://purl.obolibrary.org/obo/GO_0007165 signal transduction http://purl.obolibrary.org/obo/GO_0009755 hormone-mediated signaling pathway http://purl.obolibrary.org/obo/GO_0032870 cellular response to hormone stimulus http://purl.obolibrary.org/obo/GO_0030522 intracellular receptor signaling pathway http://purl.obolibrary.org/obo/GO_0007165 signal transduction http://purl.obolibrary.org/obo/GO_0035556 intracellular signal transduction http://purl.obolibrary.org/obo/GO_0007165 signal transduction http://purl.obolibrary.org/obo/GO_0090520 sphingolipid mediated signaling pathway http://purl.obolibrary.org/obo/GO_0007165 signal transduction http://purl.obolibrary.org/obo/GO_0023019 signal transduction involved in regulation of gene expression http://purl.obolibrary.org/obo/GO_0007165 signal transduction http://purl.obolibrary.org/obo/GO_0007167 enzyme linked receptor protein signaling pathway http://purl.obolibrary.org/obo/GO_0007166 cell surface receptor signaling pathway http://purl.obolibrary.org/obo/GO_0007215 glutamate receptor signaling pathway http://purl.obolibrary.org/obo/GO_0007166 cell surface receptor signaling pathway http://purl.obolibrary.org/obo/GO_0007186 G-protein coupled receptor signaling pathway http://purl.obolibrary.org/obo/GO_0007166 cell surface receptor signaling pathway http://purl.obolibrary.org/obo/GO_0019221 cytokine-mediated signaling pathway http://purl.obolibrary.org/obo/GO_0071345 cellular response to cytokine stimulus http://purl.obolibrary.org/obo/GO_0038003 opioid receptor signaling pathway http://purl.obolibrary.org/obo/GO_0007186 G-protein coupled receptor signaling pathway http://purl.obolibrary.org/obo/GO_0038171 cannabinoid signaling pathway http://purl.obolibrary.org/obo/GO_0007186 G-protein coupled receptor signaling pathway http://purl.obolibrary.org/obo/GO_0086100 endothelin receptor signaling pathway http://purl.obolibrary.org/obo/GO_0007186 G-protein coupled receptor signaling pathway http://purl.obolibrary.org/obo/GO_0003376 sphingosine-1-phosphate signaling pathway http://purl.obolibrary.org/obo/GO_0090520 sphingolipid mediated signaling pathway http://purl.obolibrary.org/obo/GO_0038166 angiotensin-activated signaling pathway http://purl.obolibrary.org/obo/GO_0007186 G-protein coupled receptor signaling pathway http://purl.obolibrary.org/obo/GO_0007268 synaptic transmission http://purl.obolibrary.org/obo/GO_0007267 cell-cell signaling http://purl.obolibrary.org/obo/GO_0001963 synaptic transmission, dopaminergic http://purl.obolibrary.org/obo/GO_0007270 neuron-neuron synaptic transmission http://purl.obolibrary.org/obo/GO_0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity http://purl.obolibrary.org/obo/GO_0061505 DNA topoisomerase II activity http://purl.obolibrary.org/obo/GO_0004032 alditol:NADP+ 1-oxidoreductase activity http://purl.obolibrary.org/obo/GO_0008106 alcohol dehydrogenase (NADP+) activity http://purl.obolibrary.org/obo/GO_0042974 retinoic acid receptor binding http://purl.obolibrary.org/obo/GO_0035257 nuclear hormone receptor binding http://purl.obolibrary.org/obo/GO_0008152 metabolic process http://purl.obolibrary.org/obo/GO_0008150 biological_process http://purl.obolibrary.org/obo/GO_0022610 biological adhesion http://purl.obolibrary.org/obo/GO_0008150 biological_process http://purl.obolibrary.org/obo/GO_0050896 response to stimulus http://purl.obolibrary.org/obo/GO_0008150 biological_process http://purl.obolibrary.org/obo/GO_0051234 establishment of localization http://purl.obolibrary.org/obo/GO_0008150 biological_process http://purl.obolibrary.org/obo/GO_0065007 biological regulation http://purl.obolibrary.org/obo/GO_0008150 biological_process http://purl.obolibrary.org/obo/GO_0000003 reproduction http://purl.obolibrary.org/obo/GO_0008150 biological_process http://purl.obolibrary.org/obo/GO_0002376 immune system process http://purl.obolibrary.org/obo/GO_0008150 biological_process http://purl.obolibrary.org/obo/GO_0009987 cellular process http://purl.obolibrary.org/obo/GO_0008150 biological_process http://purl.obolibrary.org/obo/GO_0022414 reproductive process http://purl.obolibrary.org/obo/GO_0008150 biological_process http://purl.obolibrary.org/obo/GO_0032501 multicellular organismal process http://purl.obolibrary.org/obo/GO_0008150 biological_process http://purl.obolibrary.org/obo/GO_0032502 developmental process http://purl.obolibrary.org/obo/GO_0008150 biological_process http://purl.obolibrary.org/obo/GO_0040007 growth http://purl.obolibrary.org/obo/GO_0008150 biological_process http://purl.obolibrary.org/obo/GO_0044699 single-organism process http://purl.obolibrary.org/obo/GO_0008150 biological_process http://purl.obolibrary.org/obo/GO_0023052 signaling http://purl.obolibrary.org/obo/GO_0008150 biological_process http://purl.obolibrary.org/obo/GO_0051179 localization http://purl.obolibrary.org/obo/GO_0008150 biological_process http://purl.obolibrary.org/obo/GO_0071840 cellular component organization or biogenesis http://purl.obolibrary.org/obo/GO_0008150 biological_process http://purl.obolibrary.org/obo/GO_0042083 5,10-methylenetetrahydrofolate-dependent methyltransferase activity http://purl.obolibrary.org/obo/GO_0008168 methyltransferase activity http://purl.obolibrary.org/obo/GO_0008169 C-methyltransferase activity http://purl.obolibrary.org/obo/GO_0008168 methyltransferase activity http://purl.obolibrary.org/obo/GO_0008171 O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0008168 methyltransferase activity http://purl.obolibrary.org/obo/GO_0008757 S-adenosylmethionine-dependent methyltransferase activity http://purl.obolibrary.org/obo/GO_0008168 methyltransferase activity http://purl.obolibrary.org/obo/GO_0009008 DNA-methyltransferase activity http://purl.obolibrary.org/obo/GO_0008168 methyltransferase activity http://purl.obolibrary.org/obo/GO_0003838 sterol 24-C-methyltransferase activity http://purl.obolibrary.org/obo/GO_0008757 S-adenosylmethionine-dependent methyltransferase activity http://purl.obolibrary.org/obo/GO_0016206 catechol O-methyltransferase activity http://purl.obolibrary.org/obo/GO_0008757 S-adenosylmethionine-dependent methyltransferase activity http://purl.obolibrary.org/obo/GO_0016805 dipeptidase activity http://purl.obolibrary.org/obo/GO_0008238 exopeptidase activity http://purl.obolibrary.org/obo/GO_0070661 leukocyte proliferation http://purl.obolibrary.org/obo/GO_0008283 cell proliferation http://purl.obolibrary.org/obo/GO_0070665 positive regulation of leukocyte proliferation http://purl.obolibrary.org/obo/GO_0070663 regulation of leukocyte proliferation http://purl.obolibrary.org/obo/GO_0019840 isoprenoid binding http://purl.obolibrary.org/obo/GO_0008289 lipid binding http://purl.obolibrary.org/obo/GO_0019829 cation-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0042625 ATPase activity, coupled to transmembrane movement of ions http://purl.obolibrary.org/obo/GO_0022890 inorganic cation transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0008324 cation transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0016411 acylglycerol O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0008374 O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0004100 chitin synthase activity http://purl.obolibrary.org/obo/GO_0008375 acetylglucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0003867 4-aminobutyrate transaminase activity http://purl.obolibrary.org/obo/GO_0008483 transaminase activity http://purl.obolibrary.org/obo/GO_0001595 angiotensin receptor activity http://purl.obolibrary.org/obo/GO_0008528 G-protein coupled peptide receptor activity http://purl.obolibrary.org/obo/GO_0004962 endothelin receptor activity http://purl.obolibrary.org/obo/GO_0008528 G-protein coupled peptide receptor activity http://purl.obolibrary.org/obo/GO_0004985 opioid receptor activity http://purl.obolibrary.org/obo/GO_0008528 G-protein coupled peptide receptor activity http://purl.obolibrary.org/obo/GO_1901607 alpha-amino acid biosynthetic process http://purl.obolibrary.org/obo/GO_1901605 alpha-amino acid metabolic process http://purl.obolibrary.org/obo/GO_0008825 cyclopropane-fatty-acyl-phospholipid synthase activity http://purl.obolibrary.org/obo/GO_0008757 S-adenosylmethionine-dependent methyltransferase activity http://purl.obolibrary.org/obo/GO_0044249 cellular biosynthetic process http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process http://purl.obolibrary.org/obo/GO_0032774 RNA biosynthetic process http://purl.obolibrary.org/obo/GO_0034654 nucleobase-containing compound biosynthetic process http://purl.obolibrary.org/obo/GO_0042060 wound healing http://purl.obolibrary.org/obo/GO_0009611 response to wounding http://purl.obolibrary.org/obo/GO_0048514 blood vessel morphogenesis http://purl.obolibrary.org/obo/GO_0044767 single-organism developmental process http://purl.obolibrary.org/obo/GO_0043401 steroid hormone mediated signaling pathway http://purl.obolibrary.org/obo/GO_0071383 cellular response to steroid hormone stimulus http://purl.obolibrary.org/obo/GO_0046879 hormone secretion http://purl.obolibrary.org/obo/GO_0023061 signal release http://purl.obolibrary.org/obo/GO_0010469 regulation of receptor activity http://purl.obolibrary.org/obo/GO_0065009 regulation of molecular function http://purl.obolibrary.org/obo/GO_0048385 regulation of retinoic acid receptor signaling pathway http://purl.obolibrary.org/obo/GO_0009966 regulation of signal transduction http://purl.obolibrary.org/obo/GO_0001959 regulation of cytokine-mediated signaling pathway http://purl.obolibrary.org/obo/GO_0060759 regulation of response to cytokine stimulus http://purl.obolibrary.org/obo/GO_0009967 positive regulation of signal transduction http://purl.obolibrary.org/obo/GO_0010647 positive regulation of cell communication http://purl.obolibrary.org/obo/GO_0033143 regulation of intracellular steroid hormone receptor signaling pathway http://purl.obolibrary.org/obo/GO_0009966 regulation of signal transduction http://purl.obolibrary.org/obo/GO_0040036 regulation of fibroblast growth factor receptor signaling pathway http://purl.obolibrary.org/obo/GO_0090287 regulation of cellular response to growth factor stimulus http://purl.obolibrary.org/obo/GO_1900169 regulation of glucocorticoid mediated signaling pathway http://purl.obolibrary.org/obo/GO_0009966 regulation of signal transduction http://purl.obolibrary.org/obo/GO_1900449 regulation of glutamate receptor signaling pathway http://purl.obolibrary.org/obo/GO_0009966 regulation of signal transduction http://purl.obolibrary.org/obo/GO_1900746 regulation of vascular endothelial growth factor signaling pathway http://purl.obolibrary.org/obo/GO_1902547 regulation of cellular response to vascular endothelial growth factor stimulus http://purl.obolibrary.org/obo/GO_1902068 regulation of sphingolipid mediated signaling pathway http://purl.obolibrary.org/obo/GO_0009966 regulation of signal transduction http://purl.obolibrary.org/obo/GO_0008277 regulation of G-protein coupled receptor protein signaling pathway http://purl.obolibrary.org/obo/GO_0009966 regulation of signal transduction http://purl.obolibrary.org/obo/GO_1902531 regulation of intracellular signal transduction http://purl.obolibrary.org/obo/GO_0009966 regulation of signal transduction http://purl.obolibrary.org/obo/GO_0033145 positive regulation of intracellular steroid hormone receptor signaling pathway http://purl.obolibrary.org/obo/GO_0033143 regulation of intracellular steroid hormone receptor signaling pathway http://purl.obolibrary.org/obo/GO_0045743 positive regulation of fibroblast growth factor receptor signaling pathway http://purl.obolibrary.org/obo/GO_0040036 regulation of fibroblast growth factor receptor signaling pathway http://purl.obolibrary.org/obo/GO_0045745 positive regulation of G-protein coupled receptor protein signaling pathway http://purl.obolibrary.org/obo/GO_0008277 regulation of G-protein coupled receptor protein signaling pathway http://purl.obolibrary.org/obo/GO_1900171 positive regulation of glucocorticoid mediated signaling pathway http://purl.obolibrary.org/obo/GO_1900169 regulation of glucocorticoid mediated signaling pathway http://purl.obolibrary.org/obo/GO_1900451 positive regulation of glutamate receptor signaling pathway http://purl.obolibrary.org/obo/GO_1900449 regulation of glutamate receptor signaling pathway http://purl.obolibrary.org/obo/GO_1900748 positive regulation of vascular endothelial growth factor signaling pathway http://purl.obolibrary.org/obo/GO_1900746 regulation of vascular endothelial growth factor signaling pathway http://purl.obolibrary.org/obo/GO_1902070 positive regulation of sphingolipid mediated signaling pathway http://purl.obolibrary.org/obo/GO_1902068 regulation of sphingolipid mediated signaling pathway http://purl.obolibrary.org/obo/GO_1902533 positive regulation of intracellular signal transduction http://purl.obolibrary.org/obo/GO_1902531 regulation of intracellular signal transduction http://purl.obolibrary.org/obo/GO_0048610 cellular process involved in reproduction http://purl.obolibrary.org/obo/GO_0009987 cellular process http://purl.obolibrary.org/obo/GO_0044763 single-organism cellular process http://purl.obolibrary.org/obo/GO_0044699 single-organism process http://purl.obolibrary.org/obo/GO_0034097 response to cytokine http://purl.obolibrary.org/obo/GO_0010033 response to organic substance http://purl.obolibrary.org/obo/GO_0071310 cellular response to organic substance http://purl.obolibrary.org/obo/GO_0070887 cellular response to chemical stimulus http://purl.obolibrary.org/obo/GO_0070848 response to growth factor http://purl.obolibrary.org/obo/GO_0010033 response to organic substance http://purl.obolibrary.org/obo/GO_0009725 response to hormone http://purl.obolibrary.org/obo/GO_0009719 response to endogenous stimulus http://purl.obolibrary.org/obo/GO_0010243 response to organonitrogen compound http://purl.obolibrary.org/obo/GO_1901698 response to nitrogen compound http://purl.obolibrary.org/obo/GO_0014070 response to organic cyclic compound http://purl.obolibrary.org/obo/GO_0010033 response to organic substance http://purl.obolibrary.org/obo/GO_0033993 response to lipid http://purl.obolibrary.org/obo/GO_0010033 response to organic substance http://purl.obolibrary.org/obo/GO_0010608 posttranscriptional regulation of gene expression http://purl.obolibrary.org/obo/GO_0010468 regulation of gene expression http://purl.obolibrary.org/obo/GO_0040029 regulation of gene expression, epigenetic http://purl.obolibrary.org/obo/GO_0010468 regulation of gene expression http://purl.obolibrary.org/obo/GO_0010628 positive regulation of gene expression http://purl.obolibrary.org/obo/GO_0010604 positive regulation of macromolecule metabolic process http://purl.obolibrary.org/obo/GO_2000112 regulation of cellular macromolecule biosynthetic process http://purl.obolibrary.org/obo/GO_0031326 regulation of cellular biosynthetic process http://purl.obolibrary.org/obo/GO_0010557 positive regulation of macromolecule biosynthetic process http://purl.obolibrary.org/obo/GO_0009891 positive regulation of biosynthetic process http://purl.obolibrary.org/obo/GO_2001141 regulation of RNA biosynthetic process http://purl.obolibrary.org/obo/GO_0051252 regulation of RNA metabolic process http://purl.obolibrary.org/obo/GO_2000573 positive regulation of DNA biosynthetic process http://purl.obolibrary.org/obo/GO_2000278 regulation of DNA biosynthetic process http://purl.obolibrary.org/obo/GO_2001008 positive regulation of cellulose biosynthetic process http://purl.obolibrary.org/obo/GO_0010676 positive regulation of cellular carbohydrate metabolic process http://purl.obolibrary.org/obo/GO_0051254 positive regulation of RNA metabolic process http://purl.obolibrary.org/obo/GO_0045935 positive regulation of nucleobase-containing compound metabolic process http://purl.obolibrary.org/obo/GO_0051054 positive regulation of DNA metabolic process http://purl.obolibrary.org/obo/GO_0045935 positive regulation of nucleobase-containing compound metabolic process http://purl.obolibrary.org/obo/GO_0051247 positive regulation of protein metabolic process http://purl.obolibrary.org/obo/GO_0051246 regulation of protein metabolic process http://purl.obolibrary.org/obo/GO_0046883 regulation of hormone secretion http://purl.obolibrary.org/obo/GO_0060341 regulation of cellular localization http://purl.obolibrary.org/obo/GO_0009966 regulation of signal transduction http://purl.obolibrary.org/obo/GO_0048583 regulation of response to stimulus http://purl.obolibrary.org/obo/GO_0051969 regulation of transmission of nerve impulse http://purl.obolibrary.org/obo/GO_0031644 regulation of neurological system process http://purl.obolibrary.org/obo/GO_0010647 positive regulation of cell communication http://purl.obolibrary.org/obo/GO_0048522 positive regulation of cellular process http://purl.obolibrary.org/obo/GO_0002028 regulation of sodium ion transport http://purl.obolibrary.org/obo/GO_0010959 regulation of metal ion transport http://purl.obolibrary.org/obo/GO_0043266 regulation of potassium ion transport http://purl.obolibrary.org/obo/GO_0010959 regulation of metal ion transport http://purl.obolibrary.org/obo/GO_0051924 regulation of calcium ion transport http://purl.obolibrary.org/obo/GO_0010959 regulation of metal ion transport http://purl.obolibrary.org/obo/GO_0004129 cytochrome-c oxidase activity http://purl.obolibrary.org/obo/GO_0016676 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor http://purl.obolibrary.org/obo/GO_0002790 peptide secretion http://purl.obolibrary.org/obo/GO_0046903 secretion http://purl.obolibrary.org/obo/GO_0000959 mitochondrial RNA metabolic process http://purl.obolibrary.org/obo/GO_0016070 RNA metabolic process http://purl.obolibrary.org/obo/GO_0004356 glutamate-ammonia ligase activity http://purl.obolibrary.org/obo/GO_0016211 ammonia ligase activity http://purl.obolibrary.org/obo/GO_0001727 lipid kinase activity http://purl.obolibrary.org/obo/GO_0016301 kinase activity http://purl.obolibrary.org/obo/GO_0035004 phosphatidylinositol 3-kinase activity http://purl.obolibrary.org/obo/GO_0016301 kinase activity http://purl.obolibrary.org/obo/GO_0034109 homotypic cell-cell adhesion http://purl.obolibrary.org/obo/GO_0016337 cell-cell adhesion http://purl.obolibrary.org/obo/GO_0016454 C-palmitoyltransferase activity http://purl.obolibrary.org/obo/GO_0016409 palmitoyltransferase activity http://purl.obolibrary.org/obo/GO_0050291 sphingosine N-acyltransferase activity http://purl.obolibrary.org/obo/GO_0016410 N-acyltransferase activity http://purl.obolibrary.org/obo/GO_0004144 diacylglycerol O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0016411 acylglycerol O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0017111 nucleoside-triphosphatase activity http://purl.obolibrary.org/obo/GO_0016462 pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0016645 oxidoreductase activity, acting on the CH-NH group of donors http://purl.obolibrary.org/obo/GO_0016491 oxidoreductase activity http://purl.obolibrary.org/obo/GO_0015002 heme-copper terminal oxidase activity http://purl.obolibrary.org/obo/GO_0016491 oxidoreductase activity http://purl.obolibrary.org/obo/GO_0016614 oxidoreductase activity, acting on CH-OH group of donors http://purl.obolibrary.org/obo/GO_0016491 oxidoreductase activity http://purl.obolibrary.org/obo/GO_0016627 oxidoreductase activity, acting on the CH-CH group of donors http://purl.obolibrary.org/obo/GO_0016491 oxidoreductase activity http://purl.obolibrary.org/obo/GO_0016638 oxidoreductase activity, acting on the CH-NH2 group of donors http://purl.obolibrary.org/obo/GO_0016491 oxidoreductase activity http://purl.obolibrary.org/obo/GO_0016651 oxidoreductase activity, acting on NAD(P)H http://purl.obolibrary.org/obo/GO_0016491 oxidoreductase activity http://purl.obolibrary.org/obo/GO_0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen http://purl.obolibrary.org/obo/GO_0016491 oxidoreductase activity http://purl.obolibrary.org/obo/GO_0016675 oxidoreductase activity, acting on a heme group of donors http://purl.obolibrary.org/obo/GO_0016491 oxidoreductase activity http://purl.obolibrary.org/obo/GO_0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen http://purl.obolibrary.org/obo/GO_0016491 oxidoreductase activity http://purl.obolibrary.org/obo/GO_0016725 oxidoreductase activity, acting on CH or CH2 groups http://purl.obolibrary.org/obo/GO_0016491 oxidoreductase activity http://purl.obolibrary.org/obo/GO_0051213 dioxygenase activity http://purl.obolibrary.org/obo/GO_0016491 oxidoreductase activity http://purl.obolibrary.org/obo/GO_0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor http://purl.obolibrary.org/obo/GO_0016614 oxidoreductase activity, acting on CH-OH group of donors http://purl.obolibrary.org/obo/GO_0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor http://purl.obolibrary.org/obo/GO_0016614 oxidoreductase activity, acting on CH-OH group of donors http://purl.obolibrary.org/obo/GO_0003938 IMP dehydrogenase activity http://purl.obolibrary.org/obo/GO_0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor http://purl.obolibrary.org/obo/GO_0004033 aldo-keto reductase (NADP) activity http://purl.obolibrary.org/obo/GO_0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor http://purl.obolibrary.org/obo/GO_0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor http://purl.obolibrary.org/obo/GO_0016627 oxidoreductase activity, acting on the CH-CH group of donors http://purl.obolibrary.org/obo/GO_0047794 cyclohexadienyl dehydrogenase activity http://purl.obolibrary.org/obo/GO_0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor http://purl.obolibrary.org/obo/GO_0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor http://purl.obolibrary.org/obo/GO_0016638 oxidoreductase activity, acting on the CH-NH2 group of donors http://purl.obolibrary.org/obo/GO_0015930 glutamate synthase activity http://purl.obolibrary.org/obo/GO_0016638 oxidoreductase activity, acting on the CH-NH2 group of donors http://purl.obolibrary.org/obo/GO_0052597 diamine oxidase activity http://purl.obolibrary.org/obo/GO_0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor http://purl.obolibrary.org/obo/GO_0004146 dihydrofolate reductase activity http://purl.obolibrary.org/obo/GO_0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor http://purl.obolibrary.org/obo/GO_0003954 NADH dehydrogenase activity http://purl.obolibrary.org/obo/GO_0016651 oxidoreductase activity, acting on NAD(P)H http://purl.obolibrary.org/obo/GO_0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor http://purl.obolibrary.org/obo/GO_0016651 oxidoreductase activity, acting on NAD(P)H http://purl.obolibrary.org/obo/GO_0003955 NAD(P)H dehydrogenase (quinone) activity http://purl.obolibrary.org/obo/GO_0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor http://purl.obolibrary.org/obo/GO_0050473 arachidonate 15-lipoxygenase activity http://purl.obolibrary.org/obo/GO_0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen http://purl.obolibrary.org/obo/GO_0003868 4-hydroxyphenylpyruvate dioxygenase activity http://purl.obolibrary.org/obo/GO_0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen http://purl.obolibrary.org/obo/GO_0004051 arachidonate 5-lipoxygenase activity http://purl.obolibrary.org/obo/GO_0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen http://purl.obolibrary.org/obo/GO_0004052 arachidonate 12-lipoxygenase activity http://purl.obolibrary.org/obo/GO_0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen http://purl.obolibrary.org/obo/GO_0016165 linoleate 13S-lipoxygenase activity http://purl.obolibrary.org/obo/GO_0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen http://purl.obolibrary.org/obo/GO_0016741 transferase activity, transferring one-carbon groups http://purl.obolibrary.org/obo/GO_0016740 transferase activity http://purl.obolibrary.org/obo/GO_0016744 transferase activity, transferring aldehyde or ketonic groups http://purl.obolibrary.org/obo/GO_0016740 transferase activity http://purl.obolibrary.org/obo/GO_0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups http://purl.obolibrary.org/obo/GO_0016740 transferase activity http://purl.obolibrary.org/obo/GO_0016746 transferase activity, transferring acyl groups http://purl.obolibrary.org/obo/GO_0016740 transferase activity http://purl.obolibrary.org/obo/GO_0016757 transferase activity, transferring glycosyl groups http://purl.obolibrary.org/obo/GO_0016740 transferase activity http://purl.obolibrary.org/obo/GO_0016769 transferase activity, transferring nitrogenous groups http://purl.obolibrary.org/obo/GO_0016740 transferase activity http://purl.obolibrary.org/obo/GO_0016772 transferase activity, transferring phosphorus-containing groups http://purl.obolibrary.org/obo/GO_0016740 transferase activity http://purl.obolibrary.org/obo/GO_0004372 glycine hydroxymethyltransferase activity http://purl.obolibrary.org/obo/GO_0016742 hydroxymethyl-, formyl- and related transferase activity http://purl.obolibrary.org/obo/GO_0003984 acetolactate synthase activity http://purl.obolibrary.org/obo/GO_0016744 transferase activity, transferring aldehyde or ketonic groups http://purl.obolibrary.org/obo/GO_0008374 O-acyltransferase activity http://purl.obolibrary.org/obo/GO_0016747 transferase activity, transferring acyl groups other than amino-acyl groups http://purl.obolibrary.org/obo/GO_0016408 C-acyltransferase activity http://purl.obolibrary.org/obo/GO_0016747 transferase activity, transferring acyl groups other than amino-acyl groups http://purl.obolibrary.org/obo/GO_0016410 N-acyltransferase activity http://purl.obolibrary.org/obo/GO_0016747 transferase activity, transferring acyl groups other than amino-acyl groups http://purl.obolibrary.org/obo/GO_0016409 palmitoyltransferase activity http://purl.obolibrary.org/obo/GO_0016747 transferase activity, transferring acyl groups other than amino-acyl groups http://purl.obolibrary.org/obo/GO_0046527 glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0016758 transferase activity, transferring hexosyl groups http://purl.obolibrary.org/obo/GO_0008375 acetylglucosaminyltransferase activity http://purl.obolibrary.org/obo/GO_0008194 UDP-glycosyltransferase activity http://purl.obolibrary.org/obo/GO_0004156 dihydropteroate synthase activity http://purl.obolibrary.org/obo/GO_0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups http://purl.obolibrary.org/obo/GO_0004659 prenyltransferase activity http://purl.obolibrary.org/obo/GO_0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups http://purl.obolibrary.org/obo/GO_0034061 DNA polymerase activity http://purl.obolibrary.org/obo/GO_0016779 nucleotidyltransferase activity http://purl.obolibrary.org/obo/GO_0034062 RNA polymerase activity http://purl.obolibrary.org/obo/GO_0016779 nucleotidyltransferase activity http://purl.obolibrary.org/obo/GO_0016788 hydrolase activity, acting on ester bonds http://purl.obolibrary.org/obo/GO_0016787 hydrolase activity http://purl.obolibrary.org/obo/GO_0016798 hydrolase activity, acting on glycosyl bonds http://purl.obolibrary.org/obo/GO_0016787 hydrolase activity http://purl.obolibrary.org/obo/GO_0019213 deacetylase activity http://purl.obolibrary.org/obo/GO_0016787 hydrolase activity http://purl.obolibrary.org/obo/GO_0008233 peptidase activity http://purl.obolibrary.org/obo/GO_0016787 hydrolase activity http://purl.obolibrary.org/obo/GO_0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds http://purl.obolibrary.org/obo/GO_0016787 hydrolase activity http://purl.obolibrary.org/obo/GO_0016817 hydrolase activity, acting on acid anhydrides http://purl.obolibrary.org/obo/GO_0016787 hydrolase activity http://purl.obolibrary.org/obo/GO_0016827 hydrolase activity, acting on acid carbon-phosphorus bonds http://purl.obolibrary.org/obo/GO_0016787 hydrolase activity http://purl.obolibrary.org/obo/GO_0017171 serine hydrolase activity http://purl.obolibrary.org/obo/GO_0016787 hydrolase activity http://purl.obolibrary.org/obo/GO_0004035 alkaline phosphatase activity http://purl.obolibrary.org/obo/GO_0016791 phosphatase activity http://purl.obolibrary.org/obo/GO_0004359 glutaminase activity http://purl.obolibrary.org/obo/GO_0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides http://purl.obolibrary.org/obo/GO_0004407 histone deacetylase activity http://purl.obolibrary.org/obo/GO_0033558 protein deacetylase activity http://purl.obolibrary.org/obo/GO_0009039 urease activity http://purl.obolibrary.org/obo/GO_0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides http://purl.obolibrary.org/obo/GO_0004000 adenosine deaminase activity http://purl.obolibrary.org/obo/GO_0019239 deaminase activity http://purl.obolibrary.org/obo/GO_0016462 pyrophosphatase activity http://purl.obolibrary.org/obo/GO_0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides http://purl.obolibrary.org/obo/GO_0016830 carbon-carbon lyase activity http://purl.obolibrary.org/obo/GO_0016829 lyase activity http://purl.obolibrary.org/obo/GO_0016835 carbon-oxygen lyase activity http://purl.obolibrary.org/obo/GO_0016829 lyase activity http://purl.obolibrary.org/obo/GO_0016840 carbon-nitrogen lyase activity http://purl.obolibrary.org/obo/GO_0016829 lyase activity http://purl.obolibrary.org/obo/GO_0016831 carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0016830 carbon-carbon lyase activity http://purl.obolibrary.org/obo/GO_0004058 aromatic-L-amino-acid decarboxylase activity http://purl.obolibrary.org/obo/GO_0016831 carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0008792 arginine decarboxylase activity http://purl.obolibrary.org/obo/GO_0016831 carboxy-lyase activity http://purl.obolibrary.org/obo/GO_0016836 hydro-lyase activity http://purl.obolibrary.org/obo/GO_0016835 carbon-oxygen lyase activity http://purl.obolibrary.org/obo/GO_0003994 aconitate hydratase activity http://purl.obolibrary.org/obo/GO_0016836 hydro-lyase activity http://purl.obolibrary.org/obo/GO_0004089 carbonate dehydratase activity http://purl.obolibrary.org/obo/GO_0016836 hydro-lyase activity http://purl.obolibrary.org/obo/GO_0045548 phenylalanine ammonia-lyase activity http://purl.obolibrary.org/obo/GO_0016841 ammonia-lyase activity http://purl.obolibrary.org/obo/GO_0003916 DNA topoisomerase activity http://purl.obolibrary.org/obo/GO_0016853 isomerase activity http://purl.obolibrary.org/obo/GO_0016879 ligase activity, forming carbon-nitrogen bonds http://purl.obolibrary.org/obo/GO_0016874 ligase activity http://purl.obolibrary.org/obo/GO_0016881 acid-amino acid ligase activity http://purl.obolibrary.org/obo/GO_0016879 ligase activity, forming carbon-nitrogen bonds http://purl.obolibrary.org/obo/GO_0016880 acid-ammonia (or amide) ligase activity http://purl.obolibrary.org/obo/GO_0016879 ligase activity, forming carbon-nitrogen bonds http://purl.obolibrary.org/obo/GO_0042623 ATPase activity, coupled http://purl.obolibrary.org/obo/GO_0016887 ATPase activity http://purl.obolibrary.org/obo/GO_0047639 alcohol oxidase activity http://purl.obolibrary.org/obo/GO_0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor http://purl.obolibrary.org/obo/GO_0004308 exo-alpha-sialidase activity http://purl.obolibrary.org/obo/GO_0016997 alpha-sialidase activity http://purl.obolibrary.org/obo/GO_0016887 ATPase activity http://purl.obolibrary.org/obo/GO_0017111 nucleoside-triphosphatase activity http://purl.obolibrary.org/obo/GO_0033558 protein deacetylase activity http://purl.obolibrary.org/obo/GO_0019213 deacetylase activity http://purl.obolibrary.org/obo/GO_0038162 erythropoietin-mediated signaling pathway http://purl.obolibrary.org/obo/GO_0036018 cellular response to erythropoietin http://purl.obolibrary.org/obo/GO_0003006 developmental process involved in reproduction http://purl.obolibrary.org/obo/GO_0032502 developmental process http://purl.obolibrary.org/obo/GO_0045765 regulation of angiogenesis http://purl.obolibrary.org/obo/GO_1901342 regulation of vasculature development http://purl.obolibrary.org/obo/GO_0023056 positive regulation of signaling http://purl.obolibrary.org/obo/GO_0048518 positive regulation of biological process http://purl.obolibrary.org/obo/GO_0051971 positive regulation of transmission of nerve impulse http://purl.obolibrary.org/obo/GO_0010647 positive regulation of cell communication http://purl.obolibrary.org/obo/GO_0022407 regulation of cell-cell adhesion http://purl.obolibrary.org/obo/GO_0030155 regulation of cell adhesion http://purl.obolibrary.org/obo/GO_0045785 positive regulation of cell adhesion http://purl.obolibrary.org/obo/GO_0048522 positive regulation of cellular process http://purl.obolibrary.org/obo/GO_0048384 retinoic acid receptor signaling pathway http://purl.obolibrary.org/obo/GO_0030522 intracellular receptor signaling pathway http://purl.obolibrary.org/obo/GO_0030518 intracellular steroid hormone receptor signaling pathway http://purl.obolibrary.org/obo/GO_0030522 intracellular receptor signaling pathway http://purl.obolibrary.org/obo/GO_0010565 regulation of cellular ketone metabolic process http://purl.obolibrary.org/obo/GO_0031323 regulation of cellular metabolic process http://purl.obolibrary.org/obo/GO_0032268 regulation of cellular protein metabolic process http://purl.obolibrary.org/obo/GO_0051246 regulation of protein metabolic process http://purl.obolibrary.org/obo/GO_0033238 regulation of cellular amine metabolic process http://purl.obolibrary.org/obo/GO_0051171 regulation of nitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_0031325 positive regulation of cellular metabolic process http://purl.obolibrary.org/obo/GO_0048522 positive regulation of cellular process http://purl.obolibrary.org/obo/GO_0031326 regulation of cellular biosynthetic process http://purl.obolibrary.org/obo/GO_0009889 regulation of biosynthetic process http://purl.obolibrary.org/obo/GO_0031329 regulation of cellular catabolic process http://purl.obolibrary.org/obo/GO_0009894 regulation of catabolic process http://purl.obolibrary.org/obo/GO_0043467 regulation of generation of precursor metabolites and energy http://purl.obolibrary.org/obo/GO_0031323 regulation of cellular metabolic process http://purl.obolibrary.org/obo/GO_0010109 regulation of photosynthesis http://purl.obolibrary.org/obo/GO_0031323 regulation of cellular metabolic process http://purl.obolibrary.org/obo/GO_0051174 regulation of phosphorus metabolic process http://purl.obolibrary.org/obo/GO_0031323 regulation of cellular metabolic process http://purl.obolibrary.org/obo/GO_0080114 positive regulation of glycine hydroxymethyltransferase activity http://purl.obolibrary.org/obo/GO_0051347 positive regulation of transferase activity http://purl.obolibrary.org/obo/GO_0031328 positive regulation of cellular biosynthetic process http://purl.obolibrary.org/obo/GO_0009891 positive regulation of biosynthetic process http://purl.obolibrary.org/obo/GO_0031331 positive regulation of cellular catabolic process http://purl.obolibrary.org/obo/GO_0009896 positive regulation of catabolic process http://purl.obolibrary.org/obo/GO_0010562 positive regulation of phosphorus metabolic process http://purl.obolibrary.org/obo/GO_0051174 regulation of phosphorus metabolic process http://purl.obolibrary.org/obo/GO_0010676 positive regulation of cellular carbohydrate metabolic process http://purl.obolibrary.org/obo/GO_0045913 positive regulation of carbohydrate metabolic process http://purl.obolibrary.org/obo/GO_0048021 regulation of melanin biosynthetic process http://purl.obolibrary.org/obo/GO_1900376 regulation of secondary metabolite biosynthetic process http://purl.obolibrary.org/obo/GO_0045723 positive regulation of fatty acid biosynthetic process http://purl.obolibrary.org/obo/GO_0046889 positive regulation of lipid biosynthetic process http://purl.obolibrary.org/obo/GO_2000284 positive regulation of cellular amino acid biosynthetic process http://purl.obolibrary.org/obo/GO_2000282 regulation of cellular amino acid biosynthetic process http://purl.obolibrary.org/obo/GO_0030813 positive regulation of nucleotide catabolic process http://purl.obolibrary.org/obo/GO_0045981 positive regulation of nucleotide metabolic process http://purl.obolibrary.org/obo/GO_0001932 regulation of protein phosphorylation http://purl.obolibrary.org/obo/GO_0042325 regulation of phosphorylation http://purl.obolibrary.org/obo/GO_0031401 positive regulation of protein modification process http://purl.obolibrary.org/obo/GO_0032270 positive regulation of cellular protein metabolic process http://purl.obolibrary.org/obo/GO_0031056 regulation of histone modification http://purl.obolibrary.org/obo/GO_1902275 regulation of chromatin organization http://purl.obolibrary.org/obo/GO_0090311 regulation of protein deacetylation http://purl.obolibrary.org/obo/GO_0031399 regulation of protein modification process http://purl.obolibrary.org/obo/GO_0035304 regulation of protein dephosphorylation http://purl.obolibrary.org/obo/GO_0035303 regulation of dephosphorylation http://purl.obolibrary.org/obo/GO_0031058 positive regulation of histone modification http://purl.obolibrary.org/obo/GO_2001252 positive regulation of chromosome organization http://purl.obolibrary.org/obo/GO_0035307 positive regulation of protein dephosphorylation http://purl.obolibrary.org/obo/GO_0035306 positive regulation of dephosphorylation http://purl.obolibrary.org/obo/GO_0090312 positive regulation of protein deacetylation http://purl.obolibrary.org/obo/GO_0090311 regulation of protein deacetylation http://purl.obolibrary.org/obo/GO_0032103 positive regulation of response to external stimulus http://purl.obolibrary.org/obo/GO_0048584 positive regulation of response to stimulus http://purl.obolibrary.org/obo/GO_0030193 regulation of blood coagulation http://purl.obolibrary.org/obo/GO_1900046 regulation of hemostasis http://purl.obolibrary.org/obo/GO_0044707 single-multicellular organism process http://purl.obolibrary.org/obo/GO_0044699 single-organism process http://purl.obolibrary.org/obo/GO_0009653 anatomical structure morphogenesis http://purl.obolibrary.org/obo/GO_0032502 developmental process http://purl.obolibrary.org/obo/GO_0044767 single-organism developmental process http://purl.obolibrary.org/obo/GO_0044699 single-organism process http://purl.obolibrary.org/obo/GO_0048646 anatomical structure formation involved in morphogenesis http://purl.obolibrary.org/obo/GO_0032502 developmental process http://purl.obolibrary.org/obo/GO_0048856 anatomical structure development http://purl.obolibrary.org/obo/GO_0032502 developmental process http://purl.obolibrary.org/obo/GO_1901896 positive regulation of calcium-transporting ATPase activity http://purl.obolibrary.org/obo/GO_1901894 regulation of calcium-transporting ATPase activity http://purl.obolibrary.org/obo/GO_2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity http://purl.obolibrary.org/obo/GO_2000371 regulation of DNA topoisomerase (ATP-hydrolyzing) activity http://purl.obolibrary.org/obo/GO_0023061 signal release http://purl.obolibrary.org/obo/GO_0032940 secretion by cell http://purl.obolibrary.org/obo/GO_0043234 protein complex http://purl.obolibrary.org/obo/GO_0032991 macromolecular complex http://purl.obolibrary.org/obo/GO_0033044 regulation of chromosome organization http://purl.obolibrary.org/obo/GO_0033043 regulation of organelle organization http://purl.obolibrary.org/obo/GO_0010638 positive regulation of organelle organization http://purl.obolibrary.org/obo/GO_0051130 positive regulation of cellular component organization http://purl.obolibrary.org/obo/GO_0010821 regulation of mitochondrion organization http://purl.obolibrary.org/obo/GO_0033043 regulation of organelle organization http://purl.obolibrary.org/obo/GO_0003964 RNA-directed DNA polymerase activity http://purl.obolibrary.org/obo/GO_0034061 DNA polymerase activity http://purl.obolibrary.org/obo/GO_0070527 platelet aggregation http://purl.obolibrary.org/obo/GO_0034109 homotypic cell-cell adhesion http://purl.obolibrary.org/obo/GO_0008120 ceramide glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0035251 UDP-glucosyltransferase activity http://purl.obolibrary.org/obo/GO_0043177 organic acid binding http://purl.obolibrary.org/obo/GO_0036094 small molecule binding http://purl.obolibrary.org/obo/GO_0001653 peptide receptor activity http://purl.obolibrary.org/obo/GO_0038023 signaling receptor activity http://purl.obolibrary.org/obo/GO_0003707 steroid hormone receptor activity http://purl.obolibrary.org/obo/GO_0038023 signaling receptor activity http://purl.obolibrary.org/obo/GO_0004888 transmembrane signaling receptor activity http://purl.obolibrary.org/obo/GO_0038023 signaling receptor activity http://purl.obolibrary.org/obo/GO_0048589 developmental growth http://purl.obolibrary.org/obo/GO_0044767 single-organism developmental process http://purl.obolibrary.org/obo/GO_0045927 positive regulation of growth http://purl.obolibrary.org/obo/GO_0048518 positive regulation of biological process http://purl.obolibrary.org/obo/GO_0048638 regulation of developmental growth http://purl.obolibrary.org/obo/GO_0050793 regulation of developmental process http://purl.obolibrary.org/obo/GO_0042098 T cell proliferation http://purl.obolibrary.org/obo/GO_0046651 lymphocyte proliferation http://purl.obolibrary.org/obo/GO_0008284 positive regulation of cell proliferation http://purl.obolibrary.org/obo/GO_0048522 positive regulation of cellular process http://purl.obolibrary.org/obo/GO_0070663 regulation of leukocyte proliferation http://purl.obolibrary.org/obo/GO_0042127 regulation of cell proliferation http://purl.obolibrary.org/obo/GO_0009593 detection of chemical stimulus http://purl.obolibrary.org/obo/GO_0051606 detection of stimulus http://purl.obolibrary.org/obo/GO_0010033 response to organic substance http://purl.obolibrary.org/obo/GO_0042221 response to chemical http://purl.obolibrary.org/obo/GO_1901700 response to oxygen-containing compound http://purl.obolibrary.org/obo/GO_0042221 response to chemical http://purl.obolibrary.org/obo/GO_1901698 response to nitrogen compound http://purl.obolibrary.org/obo/GO_0042221 response to chemical http://purl.obolibrary.org/obo/GO_0042327 positive regulation of phosphorylation http://purl.obolibrary.org/obo/GO_0045937 positive regulation of phosphate metabolic process http://purl.obolibrary.org/obo/GO_0043549 regulation of kinase activity http://purl.obolibrary.org/obo/GO_0051338 regulation of transferase activity http://purl.obolibrary.org/obo/GO_0008094 DNA-dependent ATPase activity http://purl.obolibrary.org/obo/GO_0042623 ATPase activity, coupled http://purl.obolibrary.org/obo/GO_0043492 ATPase activity, coupled to movement of substances http://purl.obolibrary.org/obo/GO_0042623 ATPase activity, coupled http://purl.obolibrary.org/obo/GO_0031406 carboxylic acid binding http://purl.obolibrary.org/obo/GO_0043177 organic acid binding http://purl.obolibrary.org/obo/GO_0043227 membrane-bounded organelle http://purl.obolibrary.org/obo/GO_0043226 organelle http://purl.obolibrary.org/obo/GO_0043229 intracellular organelle http://purl.obolibrary.org/obo/GO_0044424 intracellular part http://purl.obolibrary.org/obo/GO_0043228 non-membrane-bounded organelle http://purl.obolibrary.org/obo/GO_0043226 organelle http://purl.obolibrary.org/obo/GO_0030075 bacterial thylakoid http://purl.obolibrary.org/obo/GO_0009579 thylakoid http://purl.obolibrary.org/obo/GO_0000502 proteasome complex http://purl.obolibrary.org/obo/GO_0044424 intracellular part http://purl.obolibrary.org/obo/GO_1902494 catalytic complex http://purl.obolibrary.org/obo/GO_0043234 protein complex http://purl.obolibrary.org/obo/GO_0009512 cytochrome b6f complex http://purl.obolibrary.org/obo/GO_0044436 thylakoid part http://purl.obolibrary.org/obo/GO_0009521 photosystem http://purl.obolibrary.org/obo/GO_0044436 thylakoid part http://purl.obolibrary.org/obo/GO_1902495 transmembrane transporter complex http://purl.obolibrary.org/obo/GO_0043234 protein complex http://purl.obolibrary.org/obo/GO_0043402 glucocorticoid mediated signaling pathway http://purl.obolibrary.org/obo/GO_0071385 cellular response to glucocorticoid stimulus http://purl.obolibrary.org/obo/GO_0019752 carboxylic acid metabolic process http://purl.obolibrary.org/obo/GO_0043436 oxoacid metabolic process http://purl.obolibrary.org/obo/GO_0042548 regulation of photosynthesis, light reaction http://purl.obolibrary.org/obo/GO_0010109 regulation of photosynthesis http://purl.obolibrary.org/obo/GO_0042626 ATPase activity, coupled to transmembrane movement of substances http://purl.obolibrary.org/obo/GO_0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances http://purl.obolibrary.org/obo/GO_0000976 transcription regulatory region sequence-specific DNA binding http://purl.obolibrary.org/obo/GO_0043565 sequence-specific DNA binding http://purl.obolibrary.org/obo/GO_0001012 RNA polymerase II regulatory region DNA binding http://purl.obolibrary.org/obo/GO_0044212 transcription regulatory region DNA binding http://purl.obolibrary.org/obo/GO_0044248 cellular catabolic process http://purl.obolibrary.org/obo/GO_0009056 catabolic process http://purl.obolibrary.org/obo/GO_0046483 heterocycle metabolic process http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process http://purl.obolibrary.org/obo/GO_0015979 photosynthesis http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process http://purl.obolibrary.org/obo/GO_0009309 amine biosynthetic process http://purl.obolibrary.org/obo/GO_0009308 amine metabolic process http://purl.obolibrary.org/obo/GO_0030094 plasma membrane-derived photosystem I http://purl.obolibrary.org/obo/GO_0009522 photosystem I http://purl.obolibrary.org/obo/GO_0030096 plasma membrane-derived thylakoid photosystem II http://purl.obolibrary.org/obo/GO_0009523 photosystem II http://purl.obolibrary.org/obo/GO_0044446 intracellular organelle part http://purl.obolibrary.org/obo/GO_0044424 intracellular part http://purl.obolibrary.org/obo/GO_0019866 organelle inner membrane http://purl.obolibrary.org/obo/GO_0031090 organelle membrane http://purl.obolibrary.org/obo/GO_0045275 respiratory chain complex III http://purl.obolibrary.org/obo/GO_1902495 transmembrane transporter complex http://purl.obolibrary.org/obo/GO_0005737 cytoplasm http://purl.obolibrary.org/obo/GO_0044424 intracellular part http://purl.obolibrary.org/obo/GO_0044444 cytoplasmic part http://purl.obolibrary.org/obo/GO_0044424 intracellular part http://purl.obolibrary.org/obo/GO_0009579 thylakoid http://purl.obolibrary.org/obo/GO_0044424 intracellular part http://purl.obolibrary.org/obo/GO_0044436 thylakoid part http://purl.obolibrary.org/obo/GO_0044424 intracellular part http://purl.obolibrary.org/obo/GO_0034702 ion channel complex http://purl.obolibrary.org/obo/GO_1902495 transmembrane transporter complex http://purl.obolibrary.org/obo/GO_0044455 mitochondrial membrane part http://purl.obolibrary.org/obo/GO_0044429 mitochondrial part http://purl.obolibrary.org/obo/GO_0070469 respiratory chain http://purl.obolibrary.org/obo/GO_0044425 membrane part http://purl.obolibrary.org/obo/GO_0031224 intrinsic to membrane http://purl.obolibrary.org/obo/GO_0044425 membrane part http://purl.obolibrary.org/obo/GO_0031966 mitochondrial membrane http://purl.obolibrary.org/obo/GO_0031090 organelle membrane http://purl.obolibrary.org/obo/GO_0044429 mitochondrial part http://purl.obolibrary.org/obo/GO_0044446 intracellular organelle part http://purl.obolibrary.org/obo/GO_0031226 intrinsic to plasma membrane http://purl.obolibrary.org/obo/GO_0031224 intrinsic to membrane http://purl.obolibrary.org/obo/GO_0044700 single organism signaling http://purl.obolibrary.org/obo/GO_0023052 signaling http://purl.obolibrary.org/obo/GO_0008283 cell proliferation http://purl.obolibrary.org/obo/GO_0044699 single-organism process http://purl.obolibrary.org/obo/GO_0050817 coagulation http://purl.obolibrary.org/obo/GO_0044707 single-multicellular organism process http://purl.obolibrary.org/obo/GO_0003008 system process http://purl.obolibrary.org/obo/GO_0044707 single-multicellular organism process http://purl.obolibrary.org/obo/GO_0007275 multicellular organismal development http://purl.obolibrary.org/obo/GO_0044767 single-organism developmental process http://purl.obolibrary.org/obo/GO_0050878 regulation of body fluid levels http://purl.obolibrary.org/obo/GO_0065008 regulation of biological quality http://purl.obolibrary.org/obo/GO_0051641 cellular localization http://purl.obolibrary.org/obo/GO_0051179 localization http://purl.obolibrary.org/obo/GO_0001775 cell activation http://purl.obolibrary.org/obo/GO_0044763 single-organism cellular process http://purl.obolibrary.org/obo/GO_0007154 cell communication http://purl.obolibrary.org/obo/GO_0044763 single-organism cellular process http://purl.obolibrary.org/obo/GO_0001525 angiogenesis http://purl.obolibrary.org/obo/GO_0048646 anatomical structure formation involved in morphogenesis http://purl.obolibrary.org/obo/GO_0001568 blood vessel development http://purl.obolibrary.org/obo/GO_0048856 anatomical structure development http://purl.obolibrary.org/obo/GO_0046649 lymphocyte activation http://purl.obolibrary.org/obo/GO_0045321 leukocyte activation http://purl.obolibrary.org/obo/GO_1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus http://purl.obolibrary.org/obo/GO_0045944 positive regulation of transcription from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0072366 regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0072364 regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter http://purl.obolibrary.org/obo/GO_0042110 T cell activation http://purl.obolibrary.org/obo/GO_0046649 lymphocyte activation http://purl.obolibrary.org/obo/GO_0046651 lymphocyte proliferation http://purl.obolibrary.org/obo/GO_0032943 mononuclear cell proliferation http://purl.obolibrary.org/obo/GO_0048584 positive regulation of response to stimulus http://purl.obolibrary.org/obo/GO_0048583 regulation of response to stimulus http://purl.obolibrary.org/obo/GO_0051094 positive regulation of developmental process http://purl.obolibrary.org/obo/GO_0050793 regulation of developmental process http://purl.obolibrary.org/obo/GO_0051240 positive regulation of multicellular organismal process http://purl.obolibrary.org/obo/GO_0051239 regulation of multicellular organismal process http://purl.obolibrary.org/obo/GO_0009893 positive regulation of metabolic process http://purl.obolibrary.org/obo/GO_0019222 regulation of metabolic process http://purl.obolibrary.org/obo/GO_0048522 positive regulation of cellular process http://purl.obolibrary.org/obo/GO_0050794 regulation of cellular process http://purl.obolibrary.org/obo/GO_0051050 positive regulation of transport http://purl.obolibrary.org/obo/GO_0051049 regulation of transport http://purl.obolibrary.org/obo/GO_0051130 positive regulation of cellular component organization http://purl.obolibrary.org/obo/GO_0051128 regulation of cellular component organization http://purl.obolibrary.org/obo/GO_2000243 positive regulation of reproductive process http://purl.obolibrary.org/obo/GO_2000241 regulation of reproductive process http://purl.obolibrary.org/obo/GO_0032101 regulation of response to external stimulus http://purl.obolibrary.org/obo/GO_0048583 regulation of response to stimulus http://purl.obolibrary.org/obo/GO_0060759 regulation of response to cytokine stimulus http://purl.obolibrary.org/obo/GO_0048583 regulation of response to stimulus http://purl.obolibrary.org/obo/GO_0090287 regulation of cellular response to growth factor stimulus http://purl.obolibrary.org/obo/GO_0050794 regulation of cellular process http://purl.obolibrary.org/obo/GO_0080134 regulation of response to stress http://purl.obolibrary.org/obo/GO_0048583 regulation of response to stimulus http://purl.obolibrary.org/obo/GO_0060760 positive regulation of response to cytokine stimulus http://purl.obolibrary.org/obo/GO_0060759 regulation of response to cytokine stimulus http://purl.obolibrary.org/obo/GO_0090303 positive regulation of wound healing http://purl.obolibrary.org/obo/GO_0061041 regulation of wound healing http://purl.obolibrary.org/obo/GO_0060560 developmental growth involved in morphogenesis http://purl.obolibrary.org/obo/GO_0048589 developmental growth http://purl.obolibrary.org/obo/GO_0072359 circulatory system development http://purl.obolibrary.org/obo/GO_0048731 system development http://purl.obolibrary.org/obo/GO_0001944 vasculature development http://purl.obolibrary.org/obo/GO_0048731 system development http://purl.obolibrary.org/obo/GO_0072358 cardiovascular system development http://purl.obolibrary.org/obo/GO_0048731 system development http://purl.obolibrary.org/obo/GO_0048731 system development http://purl.obolibrary.org/obo/GO_0048856 anatomical structure development http://purl.obolibrary.org/obo/GO_0002682 regulation of immune system process http://purl.obolibrary.org/obo/GO_0050789 regulation of biological process http://purl.obolibrary.org/obo/GO_0023051 regulation of signaling http://purl.obolibrary.org/obo/GO_0050789 regulation of biological process http://purl.obolibrary.org/obo/GO_0040008 regulation of growth http://purl.obolibrary.org/obo/GO_0050789 regulation of biological process http://purl.obolibrary.org/obo/GO_0048518 positive regulation of biological process http://purl.obolibrary.org/obo/GO_0050789 regulation of biological process http://purl.obolibrary.org/obo/GO_0048583 regulation of response to stimulus http://purl.obolibrary.org/obo/GO_0050789 regulation of biological process http://purl.obolibrary.org/obo/GO_0050794 regulation of cellular process http://purl.obolibrary.org/obo/GO_0050789 regulation of biological process http://purl.obolibrary.org/obo/GO_0051128 regulation of cellular component organization http://purl.obolibrary.org/obo/GO_0050789 regulation of biological process http://purl.obolibrary.org/obo/GO_0051239 regulation of multicellular organismal process http://purl.obolibrary.org/obo/GO_0050789 regulation of biological process http://purl.obolibrary.org/obo/GO_0050793 regulation of developmental process http://purl.obolibrary.org/obo/GO_0050789 regulation of biological process http://purl.obolibrary.org/obo/GO_0019222 regulation of metabolic process http://purl.obolibrary.org/obo/GO_0050789 regulation of biological process http://purl.obolibrary.org/obo/GO_0032879 regulation of localization http://purl.obolibrary.org/obo/GO_0050789 regulation of biological process http://purl.obolibrary.org/obo/GO_2000241 regulation of reproductive process http://purl.obolibrary.org/obo/GO_0050789 regulation of biological process http://purl.obolibrary.org/obo/GO_0010646 regulation of cell communication http://purl.obolibrary.org/obo/GO_0050794 regulation of cellular process http://purl.obolibrary.org/obo/GO_0030155 regulation of cell adhesion http://purl.obolibrary.org/obo/GO_0050794 regulation of cellular process http://purl.obolibrary.org/obo/GO_0031323 regulation of cellular metabolic process http://purl.obolibrary.org/obo/GO_0019222 regulation of metabolic process http://purl.obolibrary.org/obo/GO_0033043 regulation of organelle organization http://purl.obolibrary.org/obo/GO_0051128 regulation of cellular component organization http://purl.obolibrary.org/obo/GO_0042127 regulation of cell proliferation http://purl.obolibrary.org/obo/GO_0050794 regulation of cellular process http://purl.obolibrary.org/obo/GO_0050865 regulation of cell activation http://purl.obolibrary.org/obo/GO_0050794 regulation of cellular process http://purl.obolibrary.org/obo/GO_0034762 regulation of transmembrane transport http://purl.obolibrary.org/obo/GO_0051049 regulation of transport http://purl.obolibrary.org/obo/GO_0060341 regulation of cellular localization http://purl.obolibrary.org/obo/GO_0032879 regulation of localization http://purl.obolibrary.org/obo/GO_0032226 positive regulation of synaptic transmission, dopaminergic http://purl.obolibrary.org/obo/GO_0032225 regulation of synaptic transmission, dopaminergic http://purl.obolibrary.org/obo/GO_0050867 positive regulation of cell activation http://purl.obolibrary.org/obo/GO_0048522 positive regulation of cellular process http://purl.obolibrary.org/obo/GO_0010543 regulation of platelet activation http://purl.obolibrary.org/obo/GO_0030193 regulation of blood coagulation http://purl.obolibrary.org/obo/GO_0010572 positive regulation of platelet activation http://purl.obolibrary.org/obo/GO_0010543 regulation of platelet activation http://purl.obolibrary.org/obo/GO_0007600 sensory perception http://purl.obolibrary.org/obo/GO_0050877 neurological system process http://purl.obolibrary.org/obo/GO_0019226 transmission of nerve impulse http://purl.obolibrary.org/obo/GO_0035637 multicellular organismal signaling http://purl.obolibrary.org/obo/GO_0007599 hemostasis http://purl.obolibrary.org/obo/GO_0050878 regulation of body fluid levels http://purl.obolibrary.org/obo/GO_0002791 regulation of peptide secretion http://purl.obolibrary.org/obo/GO_0090087 regulation of peptide transport http://purl.obolibrary.org/obo/GO_0051047 positive regulation of secretion http://purl.obolibrary.org/obo/GO_0051050 positive regulation of transport http://purl.obolibrary.org/obo/GO_0044030 regulation of DNA methylation http://purl.obolibrary.org/obo/GO_0051052 regulation of DNA metabolic process http://purl.obolibrary.org/obo/GO_1901858 regulation of mitochondrial DNA metabolic process http://purl.obolibrary.org/obo/GO_0010821 regulation of mitochondrion organization http://purl.obolibrary.org/obo/GO_0045766 positive regulation of angiogenesis http://purl.obolibrary.org/obo/GO_0045765 regulation of angiogenesis http://purl.obolibrary.org/obo/GO_0048639 positive regulation of developmental growth http://purl.obolibrary.org/obo/GO_0048638 regulation of developmental growth http://purl.obolibrary.org/obo/GO_2000026 regulation of multicellular organismal development http://purl.obolibrary.org/obo/GO_0050793 regulation of developmental process http://purl.obolibrary.org/obo/GO_0044057 regulation of system process http://purl.obolibrary.org/obo/GO_0051239 regulation of multicellular organismal process http://purl.obolibrary.org/obo/GO_0050818 regulation of coagulation http://purl.obolibrary.org/obo/GO_0051239 regulation of multicellular organismal process http://purl.obolibrary.org/obo/GO_1900046 regulation of hemostasis http://purl.obolibrary.org/obo/GO_0051239 regulation of multicellular organismal process http://purl.obolibrary.org/obo/GO_0031646 positive regulation of neurological system process http://purl.obolibrary.org/obo/GO_0031644 regulation of neurological system process http://purl.obolibrary.org/obo/GO_0050820 positive regulation of coagulation http://purl.obolibrary.org/obo/GO_0050818 regulation of coagulation http://purl.obolibrary.org/obo/GO_1900048 positive regulation of hemostasis http://purl.obolibrary.org/obo/GO_1900046 regulation of hemostasis http://purl.obolibrary.org/obo/GO_0006325 chromatin organization http://purl.obolibrary.org/obo/GO_0051276 chromosome organization http://purl.obolibrary.org/obo/GO_0004104 cholinesterase activity http://purl.obolibrary.org/obo/GO_0052689 carboxylic ester hydrolase activity http://purl.obolibrary.org/obo/GO_0010468 regulation of gene expression http://purl.obolibrary.org/obo/GO_0060255 regulation of macromolecule metabolic process http://purl.obolibrary.org/obo/GO_0010556 regulation of macromolecule biosynthetic process http://purl.obolibrary.org/obo/GO_0009889 regulation of biosynthetic process http://purl.obolibrary.org/obo/GO_0010604 positive regulation of macromolecule metabolic process http://purl.obolibrary.org/obo/GO_0009893 positive regulation of metabolic process http://purl.obolibrary.org/obo/GO_0001505 regulation of neurotransmitter levels http://purl.obolibrary.org/obo/GO_0065008 regulation of biological quality http://purl.obolibrary.org/obo/GO_0010817 regulation of hormone levels http://purl.obolibrary.org/obo/GO_0065008 regulation of biological quality http://purl.obolibrary.org/obo/GO_0004175 endopeptidase activity http://purl.obolibrary.org/obo/GO_0070011 peptidase activity, acting on L-amino acid peptides http://purl.obolibrary.org/obo/GO_0008234 cysteine-type peptidase activity http://purl.obolibrary.org/obo/GO_0070011 peptidase activity, acting on L-amino acid peptides http://purl.obolibrary.org/obo/GO_0008236 serine-type peptidase activity http://purl.obolibrary.org/obo/GO_0017171 serine hydrolase activity http://purl.obolibrary.org/obo/GO_0008237 metallopeptidase activity http://purl.obolibrary.org/obo/GO_0070011 peptidase activity, acting on L-amino acid peptides http://purl.obolibrary.org/obo/GO_0008238 exopeptidase activity http://purl.obolibrary.org/obo/GO_0070011 peptidase activity, acting on L-amino acid peptides http://purl.obolibrary.org/obo/GO_0032943 mononuclear cell proliferation http://purl.obolibrary.org/obo/GO_0070661 leukocyte proliferation http://purl.obolibrary.org/obo/GO_1901699 cellular response to nitrogen compound http://purl.obolibrary.org/obo/GO_1901698 response to nitrogen compound http://purl.obolibrary.org/obo/GO_1901701 cellular response to oxygen-containing compound http://purl.obolibrary.org/obo/GO_1901700 response to oxygen-containing compound http://purl.obolibrary.org/obo/GO_1900019 regulation of protein kinase C activity http://purl.obolibrary.org/obo/GO_0071900 regulation of protein serine/threonine kinase activity http://purl.obolibrary.org/obo/GO_1900020 positive regulation of protein kinase C activity http://purl.obolibrary.org/obo/GO_1900019 regulation of protein kinase C activity http://purl.obolibrary.org/obo/GO_0003676 nucleic acid binding http://purl.obolibrary.org/obo/GO_1901363 heterocyclic compound binding http://purl.obolibrary.org/obo/GO_0009308 amine metabolic process http://purl.obolibrary.org/obo/GO_1901564 organonitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_1901652 response to peptide http://purl.obolibrary.org/obo/GO_0010243 response to organonitrogen compound http://purl.obolibrary.org/obo/GO_1901342 regulation of vasculature development http://purl.obolibrary.org/obo/GO_2000026 regulation of multicellular organismal development http://purl.obolibrary.org/obo/GO_0046890 regulation of lipid biosynthetic process http://purl.obolibrary.org/obo/GO_0009889 regulation of biosynthetic process http://purl.obolibrary.org/obo/GO_0045834 positive regulation of lipid metabolic process http://purl.obolibrary.org/obo/GO_0009893 positive regulation of metabolic process http://purl.obolibrary.org/obo/GO_0043550 regulation of lipid kinase activity http://purl.obolibrary.org/obo/GO_0043549 regulation of kinase activity http://purl.obolibrary.org/obo/GO_0022409 positive regulation of cell-cell adhesion http://purl.obolibrary.org/obo/GO_0045785 positive regulation of cell adhesion http://purl.obolibrary.org/obo/GO_0034110 regulation of homotypic cell-cell adhesion http://purl.obolibrary.org/obo/GO_0022407 regulation of cell-cell adhesion http://purl.obolibrary.org/obo/GO_0034112 positive regulation of homotypic cell-cell adhesion http://purl.obolibrary.org/obo/GO_0034110 regulation of homotypic cell-cell adhesion http://purl.obolibrary.org/obo/GO_0022834 ligand-gated channel activity http://purl.obolibrary.org/obo/GO_0022836 gated channel activity http://purl.obolibrary.org/obo/GO_0030073 insulin secretion http://purl.obolibrary.org/obo/GO_0030072 peptide hormone secretion http://purl.obolibrary.org/obo/GO_0031958 corticosteroid receptor signaling pathway http://purl.obolibrary.org/obo/GO_0030518 intracellular steroid hormone receptor signaling pathway http://purl.obolibrary.org/obo/GO_0030546 receptor activator activity http://purl.obolibrary.org/obo/GO_0030545 receptor regulator activity http://purl.obolibrary.org/obo/GO_0033121 regulation of purine nucleotide catabolic process http://purl.obolibrary.org/obo/GO_1900542 regulation of purine nucleotide metabolic process http://purl.obolibrary.org/obo/GO_0033123 positive regulation of purine nucleotide catabolic process http://purl.obolibrary.org/obo/GO_1900544 positive regulation of purine nucleotide metabolic process http://purl.obolibrary.org/obo/GO_0031063 regulation of histone deacetylation http://purl.obolibrary.org/obo/GO_0090311 regulation of protein deacetylation http://purl.obolibrary.org/obo/GO_0031065 positive regulation of histone deacetylation http://purl.obolibrary.org/obo/GO_0090312 positive regulation of protein deacetylation http://purl.obolibrary.org/obo/GO_1901725 regulation of histone deacetylase activity http://purl.obolibrary.org/obo/GO_0051336 regulation of hydrolase activity http://purl.obolibrary.org/obo/GO_0031850 delta-type opioid receptor binding http://purl.obolibrary.org/obo/GO_0031628 opioid receptor binding http://purl.obolibrary.org/obo/GO_0031851 kappa-type opioid receptor binding http://purl.obolibrary.org/obo/GO_0031628 opioid receptor binding http://purl.obolibrary.org/obo/GO_0051931 regulation of sensory perception http://purl.obolibrary.org/obo/GO_0031644 regulation of neurological system process http://purl.obolibrary.org/obo/GO_0031692 alpha-1B adrenergic receptor binding http://purl.obolibrary.org/obo/GO_0031690 adrenergic receptor binding http://purl.obolibrary.org/obo/GO_0042921 glucocorticoid receptor signaling pathway http://purl.obolibrary.org/obo/GO_0031958 corticosteroid receptor signaling pathway http://purl.obolibrary.org/obo/GO_0051384 response to glucocorticoid http://purl.obolibrary.org/obo/GO_0031960 response to corticosteroid http://purl.obolibrary.org/obo/GO_0071384 cellular response to corticosteroid stimulus http://purl.obolibrary.org/obo/GO_0071383 cellular response to steroid hormone stimulus http://purl.obolibrary.org/obo/GO_0031967 organelle envelope http://purl.obolibrary.org/obo/GO_0044446 intracellular organelle part http://purl.obolibrary.org/obo/GO_0032075 positive regulation of nuclease activity http://purl.obolibrary.org/obo/GO_0051345 positive regulation of hydrolase activity http://purl.obolibrary.org/obo/GO_0060700 regulation of ribonuclease activity http://purl.obolibrary.org/obo/GO_0032069 regulation of nuclease activity http://purl.obolibrary.org/obo/GO_1900122 positive regulation of receptor binding http://purl.obolibrary.org/obo/GO_1900120 regulation of receptor binding http://purl.obolibrary.org/obo/GO_0032388 positive regulation of intracellular transport http://purl.obolibrary.org/obo/GO_0051050 positive regulation of transport http://purl.obolibrary.org/obo/GO_0022898 regulation of transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0034762 regulation of transmembrane transport http://purl.obolibrary.org/obo/GO_0032411 positive regulation of transporter activity http://purl.obolibrary.org/obo/GO_0051050 positive regulation of transport http://purl.obolibrary.org/obo/GO_0032414 positive regulation of ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0032412 regulation of ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_1901021 positive regulation of calcium ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_1901019 regulation of calcium ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_2000651 positive regulation of sodium ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_2000649 regulation of sodium ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_2001259 positive regulation of cation channel activity http://purl.obolibrary.org/obo/GO_2001257 regulation of cation channel activity http://purl.obolibrary.org/obo/GO_1901018 positive regulation of potassium ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_1901016 regulation of potassium ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_2000969 positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity http://purl.obolibrary.org/obo/GO_2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity http://purl.obolibrary.org/obo/GO_0032430 positive regulation of phospholipase A2 activity http://purl.obolibrary.org/obo/GO_0010518 positive regulation of phospholipase activity http://purl.obolibrary.org/obo/GO_0032770 positive regulation of monooxygenase activity http://purl.obolibrary.org/obo/GO_0051353 positive regulation of oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050999 regulation of nitric-oxide synthase activity http://purl.obolibrary.org/obo/GO_0032768 regulation of monooxygenase activity http://purl.obolibrary.org/obo/GO_0032771 regulation of monophenol monooxygenase activity http://purl.obolibrary.org/obo/GO_0032768 regulation of monooxygenase activity http://purl.obolibrary.org/obo/GO_0032882 regulation of chitin metabolic process http://purl.obolibrary.org/obo/GO_0051171 regulation of nitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_0032950 regulation of beta-glucan metabolic process http://purl.obolibrary.org/obo/GO_0010675 regulation of cellular carbohydrate metabolic process http://purl.obolibrary.org/obo/GO_0032883 regulation of chitin biosynthetic process http://purl.obolibrary.org/obo/GO_0032885 regulation of polysaccharide biosynthetic process http://purl.obolibrary.org/obo/GO_0032946 positive regulation of mononuclear cell proliferation http://purl.obolibrary.org/obo/GO_0070665 positive regulation of leukocyte proliferation http://purl.obolibrary.org/obo/GO_0050670 regulation of lymphocyte proliferation http://purl.obolibrary.org/obo/GO_0051249 regulation of lymphocyte activation http://purl.obolibrary.org/obo/GO_0050671 positive regulation of lymphocyte proliferation http://purl.obolibrary.org/obo/GO_0051251 positive regulation of lymphocyte activation http://purl.obolibrary.org/obo/GO_2001006 regulation of cellulose biosynthetic process http://purl.obolibrary.org/obo/GO_0032951 regulation of beta-glucan biosynthetic process http://purl.obolibrary.org/obo/GO_1902275 regulation of chromatin organization http://purl.obolibrary.org/obo/GO_0033044 regulation of chromosome organization http://purl.obolibrary.org/obo/GO_2001252 positive regulation of chromosome organization http://purl.obolibrary.org/obo/GO_0010638 positive regulation of organelle organization http://purl.obolibrary.org/obo/GO_0043462 regulation of ATPase activity http://purl.obolibrary.org/obo/GO_0051336 regulation of hydrolase activity http://purl.obolibrary.org/obo/GO_2000322 regulation of glucocorticoid receptor signaling pathway http://purl.obolibrary.org/obo/GO_0033143 regulation of intracellular steroid hormone receptor signaling pathway http://purl.obolibrary.org/obo/GO_2000324 positive regulation of glucocorticoid receptor signaling pathway http://purl.obolibrary.org/obo/GO_2000322 regulation of glucocorticoid receptor signaling pathway http://purl.obolibrary.org/obo/GO_0071377 cellular response to glucagon stimulus http://purl.obolibrary.org/obo/GO_0071375 cellular response to peptide hormone stimulus http://purl.obolibrary.org/obo/GO_0071345 cellular response to cytokine stimulus http://purl.obolibrary.org/obo/GO_0071310 cellular response to organic substance http://purl.obolibrary.org/obo/GO_0036017 response to erythropoietin http://purl.obolibrary.org/obo/GO_0034097 response to cytokine http://purl.obolibrary.org/obo/GO_0090330 regulation of platelet aggregation http://purl.obolibrary.org/obo/GO_0010543 regulation of platelet activation http://purl.obolibrary.org/obo/GO_1901731 positive regulation of platelet aggregation http://purl.obolibrary.org/obo/GO_0090330 regulation of platelet aggregation http://purl.obolibrary.org/obo/GO_0034765 regulation of ion transmembrane transport http://purl.obolibrary.org/obo/GO_0043269 regulation of ion transport http://purl.obolibrary.org/obo/GO_0034764 positive regulation of transmembrane transport http://purl.obolibrary.org/obo/GO_0051050 positive regulation of transport http://purl.obolibrary.org/obo/GO_1901381 positive regulation of potassium ion transmembrane transport http://purl.obolibrary.org/obo/GO_1901379 regulation of potassium ion transmembrane transport http://purl.obolibrary.org/obo/GO_1902307 positive regulation of sodium ion transmembrane transport http://purl.obolibrary.org/obo/GO_0010765 positive regulation of sodium ion transport http://purl.obolibrary.org/obo/GO_0042102 positive regulation of T cell proliferation http://purl.obolibrary.org/obo/GO_0050870 positive regulation of T cell activation http://purl.obolibrary.org/obo/GO_0043231 intracellular membrane-bounded organelle http://purl.obolibrary.org/obo/GO_0043229 intracellular organelle http://purl.obolibrary.org/obo/GO_0032092 positive regulation of protein binding http://purl.obolibrary.org/obo/GO_0051099 positive regulation of binding http://purl.obolibrary.org/obo/GO_1900120 regulation of receptor binding http://purl.obolibrary.org/obo/GO_0043393 regulation of protein binding http://purl.obolibrary.org/obo/GO_0033762 response to glucagon http://purl.obolibrary.org/obo/GO_0043434 response to peptide hormone http://purl.obolibrary.org/obo/GO_0071375 cellular response to peptide hormone stimulus http://purl.obolibrary.org/obo/GO_1901653 cellular response to peptide http://purl.obolibrary.org/obo/GO_0097210 response to gonadotropin-releasing hormone http://purl.obolibrary.org/obo/GO_0043434 response to peptide hormone http://purl.obolibrary.org/obo/GO_0033674 positive regulation of kinase activity http://purl.obolibrary.org/obo/GO_0051347 positive regulation of transferase activity http://purl.obolibrary.org/obo/GO_0031644 regulation of neurological system process http://purl.obolibrary.org/obo/GO_0044057 regulation of system process http://purl.obolibrary.org/obo/GO_0043085 positive regulation of catalytic activity http://purl.obolibrary.org/obo/GO_0050790 regulation of catalytic activity http://purl.obolibrary.org/obo/GO_0051091 positive regulation of sequence-specific DNA binding transcription factor activity http://purl.obolibrary.org/obo/GO_0051090 regulation of sequence-specific DNA binding transcription factor activity http://purl.obolibrary.org/obo/GO_0051099 positive regulation of binding http://purl.obolibrary.org/obo/GO_0051098 regulation of binding http://purl.obolibrary.org/obo/GO_0090358 positive regulation of tryptophan metabolic process http://purl.obolibrary.org/obo/GO_0090357 regulation of tryptophan metabolic process http://purl.obolibrary.org/obo/GO_0045979 positive regulation of nucleoside metabolic process http://purl.obolibrary.org/obo/GO_0009118 regulation of nucleoside metabolic process http://purl.obolibrary.org/obo/GO_1900544 positive regulation of purine nucleotide metabolic process http://purl.obolibrary.org/obo/GO_1900542 regulation of purine nucleotide metabolic process http://purl.obolibrary.org/obo/GO_0031960 response to corticosteroid http://purl.obolibrary.org/obo/GO_0048545 response to steroid hormone http://purl.obolibrary.org/obo/GO_0071383 cellular response to steroid hormone stimulus http://purl.obolibrary.org/obo/GO_0032870 cellular response to hormone stimulus http://purl.obolibrary.org/obo/GO_0042129 regulation of T cell proliferation http://purl.obolibrary.org/obo/GO_0050863 regulation of T cell activation http://purl.obolibrary.org/obo/GO_0022603 regulation of anatomical structure morphogenesis http://purl.obolibrary.org/obo/GO_0050793 regulation of developmental process http://purl.obolibrary.org/obo/GO_0032024 positive regulation of insulin secretion http://purl.obolibrary.org/obo/GO_0090277 positive regulation of peptide hormone secretion http://purl.obolibrary.org/obo/GO_0050806 positive regulation of synaptic transmission http://purl.obolibrary.org/obo/GO_0051971 positive regulation of transmission of nerve impulse http://purl.obolibrary.org/obo/GO_0032225 regulation of synaptic transmission, dopaminergic http://purl.obolibrary.org/obo/GO_0050804 regulation of synaptic transmission http://purl.obolibrary.org/obo/GO_0030194 positive regulation of blood coagulation http://purl.obolibrary.org/obo/GO_0030193 regulation of blood coagulation http://purl.obolibrary.org/obo/GO_1901860 positive regulation of mitochondrial DNA metabolic process http://purl.obolibrary.org/obo/GO_1901858 regulation of mitochondrial DNA metabolic process http://purl.obolibrary.org/obo/GO_0043388 positive regulation of DNA binding http://purl.obolibrary.org/obo/GO_0051101 regulation of DNA binding http://purl.obolibrary.org/obo/GO_1900132 positive regulation of lipid binding http://purl.obolibrary.org/obo/GO_1900130 regulation of lipid binding http://purl.obolibrary.org/obo/GO_0050863 regulation of T cell activation http://purl.obolibrary.org/obo/GO_0051249 regulation of lymphocyte activation http://purl.obolibrary.org/obo/GO_0050870 positive regulation of T cell activation http://purl.obolibrary.org/obo/GO_0050863 regulation of T cell activation http://purl.obolibrary.org/obo/GO_0032944 regulation of mononuclear cell proliferation http://purl.obolibrary.org/obo/GO_0070663 regulation of leukocyte proliferation http://purl.obolibrary.org/obo/GO_0071363 cellular response to growth factor stimulus http://purl.obolibrary.org/obo/GO_0070848 response to growth factor http://purl.obolibrary.org/obo/GO_0071396 cellular response to lipid http://purl.obolibrary.org/obo/GO_0033993 response to lipid http://purl.obolibrary.org/obo/GO_0071407 cellular response to organic cyclic compound http://purl.obolibrary.org/obo/GO_0014070 response to organic cyclic compound http://purl.obolibrary.org/obo/GO_0071417 cellular response to organonitrogen compound http://purl.obolibrary.org/obo/GO_0010243 response to organonitrogen compound http://purl.obolibrary.org/obo/GO_0032870 cellular response to hormone stimulus http://purl.obolibrary.org/obo/GO_0009725 response to hormone http://purl.obolibrary.org/obo/GO_0036018 cellular response to erythropoietin http://purl.obolibrary.org/obo/GO_0036017 response to erythropoietin http://purl.obolibrary.org/obo/GO_0097211 cellular response to gonadotropin-releasing hormone http://purl.obolibrary.org/obo/GO_0097210 response to gonadotropin-releasing hormone http://purl.obolibrary.org/obo/GO_0044344 cellular response to fibroblast growth factor stimulus http://purl.obolibrary.org/obo/GO_0071774 response to fibroblast growth factor http://purl.obolibrary.org/obo/GO_1902547 regulation of cellular response to vascular endothelial growth factor stimulus http://purl.obolibrary.org/obo/GO_0090287 regulation of cellular response to growth factor stimulus http://purl.obolibrary.org/obo/GO_0090296 regulation of mitochondrial DNA replication http://purl.obolibrary.org/obo/GO_1901858 regulation of mitochondrial DNA metabolic process http://purl.obolibrary.org/obo/GO_2000105 positive regulation of DNA-dependent DNA replication http://purl.obolibrary.org/obo/GO_0045740 positive regulation of DNA replication http://purl.obolibrary.org/obo/GO_1901894 regulation of calcium-transporting ATPase activity http://purl.obolibrary.org/obo/GO_0043462 regulation of ATPase activity http://purl.obolibrary.org/obo/GO_0060314 regulation of ryanodine-sensitive calcium-release channel activity http://purl.obolibrary.org/obo/GO_2001257 regulation of cation channel activity http://purl.obolibrary.org/obo/GO_0060316 positive regulation of ryanodine-sensitive calcium-release channel activity http://purl.obolibrary.org/obo/GO_0060314 regulation of ryanodine-sensitive calcium-release channel activity http://purl.obolibrary.org/obo/GO_0043434 response to peptide hormone http://purl.obolibrary.org/obo/GO_0009725 response to hormone http://purl.obolibrary.org/obo/GO_1901653 cellular response to peptide http://purl.obolibrary.org/obo/GO_1901701 cellular response to oxygen-containing compound http://purl.obolibrary.org/obo/GO_0046965 retinoid X receptor binding http://purl.obolibrary.org/obo/GO_0042974 retinoic acid receptor binding http://purl.obolibrary.org/obo/GO_0043168 anion binding http://purl.obolibrary.org/obo/GO_0043167 ion binding http://purl.obolibrary.org/obo/GO_0043232 intracellular non-membrane-bounded organelle http://purl.obolibrary.org/obo/GO_0043228 non-membrane-bounded organelle http://purl.obolibrary.org/obo/GO_0043268 positive regulation of potassium ion transport http://purl.obolibrary.org/obo/GO_0043270 positive regulation of ion transport http://purl.obolibrary.org/obo/GO_2000679 positive regulation of transcription regulatory region DNA binding http://purl.obolibrary.org/obo/GO_2000677 regulation of transcription regulatory region DNA binding http://purl.obolibrary.org/obo/GO_0043551 regulation of phosphatidylinositol 3-kinase activity http://purl.obolibrary.org/obo/GO_0043550 regulation of lipid kinase activity http://purl.obolibrary.org/obo/GO_0043552 positive regulation of phosphatidylinositol 3-kinase activity http://purl.obolibrary.org/obo/GO_0090218 positive regulation of lipid kinase activity http://purl.obolibrary.org/obo/GO_0038036 sphingosine-1-phosphate receptor activity http://purl.obolibrary.org/obo/GO_0045125 bioactive lipid receptor activity http://purl.obolibrary.org/obo/GO_2000476 positive regulation of opioid receptor signaling pathway http://purl.obolibrary.org/obo/GO_2000474 regulation of opioid receptor signaling pathway http://purl.obolibrary.org/obo/GO_0035306 positive regulation of dephosphorylation http://purl.obolibrary.org/obo/GO_0035303 regulation of dephosphorylation http://purl.obolibrary.org/obo/GO_0046034 ATP metabolic process http://purl.obolibrary.org/obo/GO_0009205 purine ribonucleoside triphosphate metabolic process http://purl.obolibrary.org/obo/GO_0043393 regulation of protein binding http://purl.obolibrary.org/obo/GO_0051098 regulation of binding http://purl.obolibrary.org/obo/GO_0051101 regulation of DNA binding http://purl.obolibrary.org/obo/GO_0051098 regulation of binding http://purl.obolibrary.org/obo/GO_1900130 regulation of lipid binding http://purl.obolibrary.org/obo/GO_0051098 regulation of binding http://purl.obolibrary.org/obo/GO_2000677 regulation of transcription regulatory region DNA binding http://purl.obolibrary.org/obo/GO_0051101 regulation of DNA binding http://purl.obolibrary.org/obo/GO_0050804 regulation of synaptic transmission http://purl.obolibrary.org/obo/GO_0051969 regulation of transmission of nerve impulse http://purl.obolibrary.org/obo/GO_0071774 response to fibroblast growth factor http://purl.obolibrary.org/obo/GO_0009719 response to endogenous stimulus http://purl.obolibrary.org/obo/GO_0035924 cellular response to vascular endothelial growth factor stimulus http://purl.obolibrary.org/obo/GO_0071363 cellular response to growth factor stimulus http://purl.obolibrary.org/obo/GO_0050796 regulation of insulin secretion http://purl.obolibrary.org/obo/GO_0090276 regulation of peptide hormone secretion http://purl.obolibrary.org/obo/GO_1901727 positive regulation of histone deacetylase activity http://purl.obolibrary.org/obo/GO_1901725 regulation of histone deacetylase activity http://purl.obolibrary.org/obo/GO_0090297 positive regulation of mitochondrial DNA replication http://purl.obolibrary.org/obo/GO_2000105 positive regulation of DNA-dependent DNA replication http://purl.obolibrary.org/obo/GO_1900005 positive regulation of serine-type endopeptidase activity http://purl.obolibrary.org/obo/GO_0010950 positive regulation of endopeptidase activity http://purl.obolibrary.org/obo/GO_1901016 regulation of potassium ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0032412 regulation of ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_2000649 regulation of sodium ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0032412 regulation of ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_2000120 positive regulation of sodium-dependent phosphate transport http://purl.obolibrary.org/obo/GO_0043270 positive regulation of ion transport http://purl.obolibrary.org/obo/ENVO_00000002 anthropogenic geographic feature http://purl.obolibrary.org/obo/ENVO_00000000 geographic feature http://purl.obolibrary.org/obo/ENVO_00000063 water body http://purl.obolibrary.org/obo/ENVO_00000000 geographic feature http://purl.obolibrary.org/obo/ENVO_01000687 coast http://purl.obolibrary.org/obo/ENVO_00000000 geographic feature http://purl.obolibrary.org/obo/ENVO_00000070 constructed feature http://purl.obolibrary.org/obo/ENVO_00000002 anthropogenic geographic feature http://purl.obolibrary.org/obo/ENVO_00000022 river http://purl.obolibrary.org/obo/ENVO_00000023 stream http://purl.obolibrary.org/obo/ENVO_00000023 stream http://purl.obolibrary.org/obo/ENVO_00000029 watercourse http://purl.obolibrary.org/obo/ENVO_01000618 lotic water body http://purl.obolibrary.org/obo/ENVO_00000063 water body http://purl.obolibrary.org/obo/ENVO_01000710 flood http://purl.obolibrary.org/obo/ENVO_00000063 water body http://purl.obolibrary.org/obo/ENVO_00002011 fresh water http://purl.obolibrary.org/obo/ENVO_00002006 water http://purl.obolibrary.org/obo/ENVO_00002186 contaminated water http://purl.obolibrary.org/obo/ENVO_00002006 water http://purl.obolibrary.org/obo/ENVO_00002001 waste water http://purl.obolibrary.org/obo/ENVO_00002186 contaminated water http://purl.obolibrary.org/obo/ENVO_00002264 waste http://purl.obolibrary.org/obo/ENVO_0010001 anthropogenic environmental material http://purl.obolibrary.org/obo/ENVO_00000428 biome http://purl.obolibrary.org/obo/ENVO_01000254 environmental system http://purl.obolibrary.org/obo/ENVO_01000268 atmospheric water vapour http://purl.obolibrary.org/obo/ENVO_01000266 water vapour http://purl.obolibrary.org/obo/ENVO_00000029 watercourse http://purl.obolibrary.org/obo/ENVO_01000618 lotic water body http://purl.obolibrary.org/obo/ENVO_01000629 climate change http://purl.obolibrary.org/obo/ENVO_02500000 environmental system process http://purl.obolibrary.org/obo/ENVO_01000634 volcanic eruption http://purl.obolibrary.org/obo/ENVO_02500000 environmental system process http://purl.obolibrary.org/obo/ENVO_01000677 earthquake http://purl.obolibrary.org/obo/ENVO_02500000 environmental system process http://purl.obolibrary.org/obo/ENVO_01000689 tsunami http://purl.obolibrary.org/obo/ENVO_02500000 environmental system process http://purl.obolibrary.org/obo/ENVO_01000690 mass wasting http://purl.obolibrary.org/obo/ENVO_02500000 environmental system process http://purl.obolibrary.org/obo/ENVO_01000694 geological subsidence http://purl.obolibrary.org/obo/ENVO_02500000 environmental system process http://purl.obolibrary.org/obo/ENVO_01000702 ash fall process http://purl.obolibrary.org/obo/ENVO_02500000 environmental system process http://purl.obolibrary.org/obo/ENVO_01000730 lava flow process http://purl.obolibrary.org/obo/ENVO_02500000 environmental system process http://purl.obolibrary.org/obo/ENVO_02500001 desertification http://purl.obolibrary.org/obo/ENVO_02500000 environmental system process http://purl.obolibrary.org/obo/ENVO_02500002 flooding http://purl.obolibrary.org/obo/ENVO_02500000 environmental system process http://purl.obolibrary.org/obo/ENVO_02500005 land degradation http://purl.obolibrary.org/obo/ENVO_02500000 environmental system process http://purl.obolibrary.org/obo/ENVO_02500011 afforestation http://purl.obolibrary.org/obo/ENVO_02500000 environmental system process http://purl.obolibrary.org/obo/ENVO_02500012 deforestation http://purl.obolibrary.org/obo/ENVO_02500000 environmental system process http://purl.obolibrary.org/obo/ENVO_02500027 anthropogenic environmental process http://purl.obolibrary.org/obo/ENVO_02500000 environmental system process http://purl.obolibrary.org/obo/ENVO_02500032 revegetation http://purl.obolibrary.org/obo/ENVO_02500000 environmental system process http://purl.obolibrary.org/obo/ENVO_01000254 environmental system http://purl.obolibrary.org/obo/RO_0002577 system http://purl.obolibrary.org/obo/GO_0070011 peptidase activity, acting on L-amino acid peptides http://purl.obolibrary.org/obo/GO_0008233 peptidase activity http://purl.obolibrary.org/obo/GO_2000474 regulation of opioid receptor signaling pathway http://purl.obolibrary.org/obo/GO_0008277 regulation of G-protein coupled receptor protein signaling pathway http://purl.obolibrary.org/obo/GO_0009125 nucleoside monophosphate catabolic process http://purl.obolibrary.org/obo/GO_1901292 nucleoside phosphate catabolic process http://purl.obolibrary.org/obo/GO_0009126 purine nucleoside monophosphate metabolic process http://purl.obolibrary.org/obo/GO_0009123 nucleoside monophosphate metabolic process http://purl.obolibrary.org/obo/GO_0009161 ribonucleoside monophosphate metabolic process http://purl.obolibrary.org/obo/GO_0009123 nucleoside monophosphate metabolic process http://purl.obolibrary.org/obo/GO_0009128 purine nucleoside monophosphate catabolic process http://purl.obolibrary.org/obo/GO_0009126 purine nucleoside monophosphate metabolic process http://purl.obolibrary.org/obo/GO_0009158 ribonucleoside monophosphate catabolic process http://purl.obolibrary.org/obo/GO_0009161 ribonucleoside monophosphate metabolic process http://purl.obolibrary.org/obo/GO_0009167 purine ribonucleoside monophosphate metabolic process http://purl.obolibrary.org/obo/GO_0009161 ribonucleoside monophosphate metabolic process http://purl.obolibrary.org/obo/GO_0009169 purine ribonucleoside monophosphate catabolic process http://purl.obolibrary.org/obo/GO_0009167 purine ribonucleoside monophosphate metabolic process http://purl.obolibrary.org/obo/GO_0009143 nucleoside triphosphate catabolic process http://purl.obolibrary.org/obo/GO_1901292 nucleoside phosphate catabolic process http://purl.obolibrary.org/obo/GO_0009144 purine nucleoside triphosphate metabolic process http://purl.obolibrary.org/obo/GO_0009141 nucleoside triphosphate metabolic process http://purl.obolibrary.org/obo/GO_0009199 ribonucleoside triphosphate metabolic process http://purl.obolibrary.org/obo/GO_0009141 nucleoside triphosphate metabolic process http://purl.obolibrary.org/obo/GO_0009146 purine nucleoside triphosphate catabolic process http://purl.obolibrary.org/obo/GO_0009144 purine nucleoside triphosphate metabolic process http://purl.obolibrary.org/obo/GO_0009203 ribonucleoside triphosphate catabolic process http://purl.obolibrary.org/obo/GO_0009199 ribonucleoside triphosphate metabolic process http://purl.obolibrary.org/obo/GO_0009205 purine ribonucleoside triphosphate metabolic process http://purl.obolibrary.org/obo/GO_0009199 ribonucleoside triphosphate metabolic process http://purl.obolibrary.org/obo/GO_0009207 purine ribonucleoside triphosphate catabolic process http://purl.obolibrary.org/obo/GO_0009205 purine ribonucleoside triphosphate metabolic process http://purl.obolibrary.org/obo/GO_0009522 photosystem I http://purl.obolibrary.org/obo/GO_0009521 photosystem http://purl.obolibrary.org/obo/GO_0009523 photosystem II http://purl.obolibrary.org/obo/GO_0009521 photosystem http://purl.obolibrary.org/obo/GO_0071495 cellular response to endogenous stimulus http://purl.obolibrary.org/obo/GO_0009719 response to endogenous stimulus http://purl.obolibrary.org/obo/GO_0048545 response to steroid hormone http://purl.obolibrary.org/obo/GO_0033993 response to lipid http://purl.obolibrary.org/obo/GO_0009891 positive regulation of biosynthetic process http://purl.obolibrary.org/obo/GO_0009893 positive regulation of metabolic process http://purl.obolibrary.org/obo/GO_1900378 positive regulation of secondary metabolite biosynthetic process http://purl.obolibrary.org/obo/GO_1900376 regulation of secondary metabolite biosynthetic process http://purl.obolibrary.org/obo/GO_0051173 positive regulation of nitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_0051171 regulation of nitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_0009896 positive regulation of catabolic process http://purl.obolibrary.org/obo/GO_0009894 regulation of catabolic process http://purl.obolibrary.org/obo/GO_0032429 regulation of phospholipase A2 activity http://purl.obolibrary.org/obo/GO_0010517 regulation of phospholipase activity http://purl.obolibrary.org/obo/GO_0010518 positive regulation of phospholipase activity http://purl.obolibrary.org/obo/GO_0060193 positive regulation of lipase activity http://purl.obolibrary.org/obo/GO_1900274 regulation of phospholipase C activity http://purl.obolibrary.org/obo/GO_0010517 regulation of phospholipase activity http://purl.obolibrary.org/obo/GO_0010863 positive regulation of phospholipase C activity http://purl.obolibrary.org/obo/GO_1900274 regulation of phospholipase C activity http://purl.obolibrary.org/obo/GO_0010822 positive regulation of mitochondrion organization http://purl.obolibrary.org/obo/GO_0010821 regulation of mitochondrion organization http://purl.obolibrary.org/obo/GO_0010694 positive regulation of alkaline phosphatase activity http://purl.obolibrary.org/obo/GO_0010922 positive regulation of phosphatase activity http://purl.obolibrary.org/obo/GO_0070131 positive regulation of mitochondrial translation http://purl.obolibrary.org/obo/GO_0070129 regulation of mitochondrial translation http://purl.obolibrary.org/obo/GO_2000371 regulation of DNA topoisomerase (ATP-hydrolyzing) activity http://purl.obolibrary.org/obo/GO_0043462 regulation of ATPase activity http://purl.obolibrary.org/obo/GO_0043666 regulation of phosphoprotein phosphatase activity http://purl.obolibrary.org/obo/GO_0010921 regulation of phosphatase activity http://purl.obolibrary.org/obo/GO_0010692 regulation of alkaline phosphatase activity http://purl.obolibrary.org/obo/GO_0010921 regulation of phosphatase activity http://purl.obolibrary.org/obo/GO_0010922 positive regulation of phosphatase activity http://purl.obolibrary.org/obo/GO_0051345 positive regulation of hydrolase activity http://purl.obolibrary.org/obo/GO_0010950 positive regulation of endopeptidase activity http://purl.obolibrary.org/obo/GO_0052548 regulation of endopeptidase activity http://purl.obolibrary.org/obo/GO_2000118 regulation of sodium-dependent phosphate transport http://purl.obolibrary.org/obo/GO_0010966 regulation of phosphate transport http://purl.obolibrary.org/obo/GO_0015079 potassium ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0046873 metal ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015081 sodium ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0046873 metal ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015078 hydrogen ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015077 monovalent inorganic cation transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0022829 wide pore channel activity http://purl.obolibrary.org/obo/GO_0015267 channel activity http://purl.obolibrary.org/obo/GO_0022836 gated channel activity http://purl.obolibrary.org/obo/GO_0015267 channel activity http://purl.obolibrary.org/obo/GO_0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015399 primary active transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0016569 covalent chromatin modification http://purl.obolibrary.org/obo/GO_0016568 chromatin modification http://purl.obolibrary.org/obo/GO_0016595 glutamate binding http://purl.obolibrary.org/obo/GO_0016597 amino acid binding http://purl.obolibrary.org/obo/GO_0016676 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor http://purl.obolibrary.org/obo/GO_0016675 oxidoreductase activity, acting on a heme group of donors http://purl.obolibrary.org/obo/GO_0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen http://purl.obolibrary.org/obo/GO_0051213 dioxygenase activity http://purl.obolibrary.org/obo/GO_0070330 aromatase activity http://purl.obolibrary.org/obo/GO_0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen http://purl.obolibrary.org/obo/GO_0016727 oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor http://purl.obolibrary.org/obo/GO_0016725 oxidoreductase activity, acting on CH or CH2 groups http://purl.obolibrary.org/obo/GO_0016747 transferase activity, transferring acyl groups other than amino-acyl groups http://purl.obolibrary.org/obo/GO_0016746 transferase activity, transferring acyl groups http://purl.obolibrary.org/obo/GO_0008373 sialyltransferase activity http://purl.obolibrary.org/obo/GO_0016757 transferase activity, transferring glycosyl groups http://purl.obolibrary.org/obo/GO_0016758 transferase activity, transferring hexosyl groups http://purl.obolibrary.org/obo/GO_0016757 transferase activity, transferring glycosyl groups http://purl.obolibrary.org/obo/GO_0016763 transferase activity, transferring pentosyl groups http://purl.obolibrary.org/obo/GO_0016757 transferase activity, transferring glycosyl groups http://purl.obolibrary.org/obo/GO_0008194 UDP-glycosyltransferase activity http://purl.obolibrary.org/obo/GO_0016757 transferase activity, transferring glycosyl groups http://purl.obolibrary.org/obo/GO_0008483 transaminase activity http://purl.obolibrary.org/obo/GO_0016769 transferase activity, transferring nitrogenous groups http://purl.obolibrary.org/obo/GO_0016301 kinase activity http://purl.obolibrary.org/obo/GO_0016772 transferase activity, transferring phosphorus-containing groups http://purl.obolibrary.org/obo/GO_0016773 phosphotransferase activity, alcohol group as acceptor http://purl.obolibrary.org/obo/GO_0016772 transferase activity, transferring phosphorus-containing groups http://purl.obolibrary.org/obo/GO_0016779 nucleotidyltransferase activity http://purl.obolibrary.org/obo/GO_0016772 transferase activity, transferring phosphorus-containing groups http://purl.obolibrary.org/obo/GO_0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides http://purl.obolibrary.org/obo/GO_0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds http://purl.obolibrary.org/obo/GO_0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines http://purl.obolibrary.org/obo/GO_0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds http://purl.obolibrary.org/obo/GO_0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides http://purl.obolibrary.org/obo/GO_0016817 hydrolase activity, acting on acid anhydrides http://purl.obolibrary.org/obo/GO_0033978 phosphonopyruvate hydrolase activity http://purl.obolibrary.org/obo/GO_0016827 hydrolase activity, acting on acid carbon-phosphorus bonds http://purl.obolibrary.org/obo/GO_0016841 ammonia-lyase activity http://purl.obolibrary.org/obo/GO_0016840 carbon-nitrogen lyase activity http://purl.obolibrary.org/obo/GO_0016211 ammonia ligase activity http://purl.obolibrary.org/obo/GO_0016880 acid-ammonia (or amide) ligase activity http://purl.obolibrary.org/obo/GO_0051448 gonadotropin-releasing hormone binding http://purl.obolibrary.org/obo/GO_0017046 peptide hormone binding http://purl.obolibrary.org/obo/GO_0018212 peptidyl-tyrosine modification http://purl.obolibrary.org/obo/GO_0018193 peptidyl-amino acid modification http://purl.obolibrary.org/obo/GO_0043455 regulation of secondary metabolic process http://purl.obolibrary.org/obo/GO_0019222 regulation of metabolic process http://purl.obolibrary.org/obo/GO_0080090 regulation of primary metabolic process http://purl.obolibrary.org/obo/GO_0019222 regulation of metabolic process http://purl.obolibrary.org/obo/GO_0060255 regulation of macromolecule metabolic process http://purl.obolibrary.org/obo/GO_0019222 regulation of metabolic process http://purl.obolibrary.org/obo/GO_0009889 regulation of biosynthetic process http://purl.obolibrary.org/obo/GO_0019222 regulation of metabolic process http://purl.obolibrary.org/obo/GO_0009894 regulation of catabolic process http://purl.obolibrary.org/obo/GO_0019222 regulation of metabolic process http://purl.obolibrary.org/obo/GO_0050790 regulation of catalytic activity http://purl.obolibrary.org/obo/GO_0065009 regulation of molecular function http://purl.obolibrary.org/obo/GO_0051171 regulation of nitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_0019222 regulation of metabolic process http://purl.obolibrary.org/obo/GO_0015267 channel activity http://purl.obolibrary.org/obo/GO_0022803 passive transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015399 primary active transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0022804 active transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0022835 transmitter-gated channel activity http://purl.obolibrary.org/obo/GO_0022834 ligand-gated channel activity http://purl.obolibrary.org/obo/GO_0072509 divalent inorganic cation transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0022890 inorganic cation transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0015077 monovalent inorganic cation transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0022890 inorganic cation transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0046873 metal ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0022890 inorganic cation transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0009767 photosynthetic electron transport chain http://purl.obolibrary.org/obo/GO_0022900 electron transport chain http://purl.obolibrary.org/obo/GO_0016021 integral to membrane http://purl.obolibrary.org/obo/GO_0031224 intrinsic to membrane http://purl.obolibrary.org/obo/GO_1901019 regulation of calcium ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0051924 regulation of calcium ion transport http://purl.obolibrary.org/obo/GO_2001257 regulation of cation channel activity http://purl.obolibrary.org/obo/GO_0032412 regulation of ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0051049 regulation of transport http://purl.obolibrary.org/obo/GO_0032879 regulation of localization http://purl.obolibrary.org/obo/GO_0071805 potassium ion transmembrane transport http://purl.obolibrary.org/obo/GO_0071804 cellular potassium ion transport http://purl.obolibrary.org/obo/GO_0010921 regulation of phosphatase activity http://purl.obolibrary.org/obo/GO_0051336 regulation of hydrolase activity http://purl.obolibrary.org/obo/GO_0015662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism http://purl.obolibrary.org/obo/GO_0042625 ATPase activity, coupled to transmembrane movement of ions http://purl.obolibrary.org/obo/GO_0044070 regulation of anion transport http://purl.obolibrary.org/obo/GO_0043269 regulation of ion transport http://purl.obolibrary.org/obo/GO_0010959 regulation of metal ion transport http://purl.obolibrary.org/obo/GO_0043269 regulation of ion transport http://purl.obolibrary.org/obo/GO_0010155 regulation of proton transport http://purl.obolibrary.org/obo/GO_0043269 regulation of ion transport http://purl.obolibrary.org/obo/GO_0043270 positive regulation of ion transport http://purl.obolibrary.org/obo/GO_0051050 positive regulation of transport http://purl.obolibrary.org/obo/GO_0051928 positive regulation of calcium ion transport http://purl.obolibrary.org/obo/GO_0051924 regulation of calcium ion transport http://purl.obolibrary.org/obo/GO_0032781 positive regulation of ATPase activity http://purl.obolibrary.org/obo/GO_0051345 positive regulation of hydrolase activity http://purl.obolibrary.org/obo/GO_0044430 cytoskeletal part http://purl.obolibrary.org/obo/GO_0044446 intracellular organelle part http://purl.obolibrary.org/obo/GO_0051338 regulation of transferase activity http://purl.obolibrary.org/obo/GO_0050790 regulation of catalytic activity http://purl.obolibrary.org/obo/GO_0051340 regulation of ligase activity http://purl.obolibrary.org/obo/GO_0050790 regulation of catalytic activity http://purl.obolibrary.org/obo/GO_0010911 regulation of isomerase activity http://purl.obolibrary.org/obo/GO_0050790 regulation of catalytic activity http://purl.obolibrary.org/obo/GO_0051336 regulation of hydrolase activity http://purl.obolibrary.org/obo/GO_0050790 regulation of catalytic activity http://purl.obolibrary.org/obo/GO_0051339 regulation of lyase activity http://purl.obolibrary.org/obo/GO_0050790 regulation of catalytic activity http://purl.obolibrary.org/obo/GO_0051341 regulation of oxidoreductase activity http://purl.obolibrary.org/obo/GO_0050790 regulation of catalytic activity http://purl.obolibrary.org/obo/GO_0051588 regulation of neurotransmitter transport http://purl.obolibrary.org/obo/GO_0051049 regulation of transport http://purl.obolibrary.org/obo/GO_0051046 regulation of secretion http://purl.obolibrary.org/obo/GO_0051049 regulation of transport http://purl.obolibrary.org/obo/GO_0090087 regulation of peptide transport http://purl.obolibrary.org/obo/GO_0051049 regulation of transport http://purl.obolibrary.org/obo/GO_0032386 regulation of intracellular transport http://purl.obolibrary.org/obo/GO_0060341 regulation of cellular localization http://purl.obolibrary.org/obo/GO_0032409 regulation of transporter activity http://purl.obolibrary.org/obo/GO_0065009 regulation of molecular function http://purl.obolibrary.org/obo/GO_0043269 regulation of ion transport http://purl.obolibrary.org/obo/GO_0051049 regulation of transport http://purl.obolibrary.org/obo/GO_0051952 regulation of amine transport http://purl.obolibrary.org/obo/GO_0051049 regulation of transport http://purl.obolibrary.org/obo/GO_0051954 positive regulation of amine transport http://purl.obolibrary.org/obo/GO_0051952 regulation of amine transport http://purl.obolibrary.org/obo/GO_0019220 regulation of phosphate metabolic process http://purl.obolibrary.org/obo/GO_0051174 regulation of phosphorus metabolic process http://purl.obolibrary.org/obo/GO_0052547 regulation of peptidase activity http://purl.obolibrary.org/obo/GO_0051336 regulation of hydrolase activity http://purl.obolibrary.org/obo/GO_0060191 regulation of lipase activity http://purl.obolibrary.org/obo/GO_0051336 regulation of hydrolase activity http://purl.obolibrary.org/obo/GO_0032768 regulation of monooxygenase activity http://purl.obolibrary.org/obo/GO_0051341 regulation of oxidoreductase activity http://purl.obolibrary.org/obo/GO_0090045 positive regulation of deacetylase activity http://purl.obolibrary.org/obo/GO_0051345 positive regulation of hydrolase activity http://purl.obolibrary.org/obo/GO_0010952 positive regulation of peptidase activity http://purl.obolibrary.org/obo/GO_0052547 regulation of peptidase activity http://purl.obolibrary.org/obo/GO_0060193 positive regulation of lipase activity http://purl.obolibrary.org/obo/GO_0060191 regulation of lipase activity http://purl.obolibrary.org/obo/GO_0050906 detection of stimulus involved in sensory perception http://purl.obolibrary.org/obo/GO_0051606 detection of stimulus http://purl.obolibrary.org/obo/GO_0090493 catecholamine uptake http://purl.obolibrary.org/obo/GO_0051937 catecholamine transport http://purl.obolibrary.org/obo/GO_0052548 regulation of endopeptidase activity http://purl.obolibrary.org/obo/GO_0052547 regulation of peptidase activity http://purl.obolibrary.org/obo/GO_1900003 regulation of serine-type endopeptidase activity http://purl.obolibrary.org/obo/GO_0052548 regulation of endopeptidase activity http://purl.obolibrary.org/obo/GO_0051004 regulation of lipoprotein lipase activity http://purl.obolibrary.org/obo/GO_0060191 regulation of lipase activity http://purl.obolibrary.org/obo/GO_0010517 regulation of phospholipase activity http://purl.obolibrary.org/obo/GO_0060191 regulation of lipase activity http://purl.obolibrary.org/obo/GO_0061365 positive regulation of triglyceride lipase activity http://purl.obolibrary.org/obo/GO_0060193 positive regulation of lipase activity http://purl.obolibrary.org/obo/GO_0044093 positive regulation of molecular function http://purl.obolibrary.org/obo/GO_0065009 regulation of molecular function http://purl.obolibrary.org/obo/GO_0051098 regulation of binding http://purl.obolibrary.org/obo/GO_0065009 regulation of molecular function http://purl.obolibrary.org/obo/GO_0016043 cellular component organization http://purl.obolibrary.org/obo/GO_0071840 cellular component organization or biogenesis http://purl.obolibrary.org/obo/GO_0061041 regulation of wound healing http://purl.obolibrary.org/obo/GO_0080134 regulation of response to stress http://purl.obolibrary.org/obo/GO_0060699 regulation of endoribonuclease activity http://purl.obolibrary.org/obo/GO_0060700 regulation of ribonuclease activity http://purl.obolibrary.org/obo/ENVO_00000856 city http://purl.obolibrary.org/obo/ENVO_00000062 populated place http://purl.obolibrary.org/obo/ENVO_00000062 populated place http://purl.obolibrary.org/obo/ENVO_00000070 constructed feature http://purl.obolibrary.org/obo/ENVO_00000446 terrestrial biome http://purl.obolibrary.org/obo/ENVO_00000428 biome http://purl.obolibrary.org/obo/ENVO_01000219 anthropogenic terrestrial biome http://purl.obolibrary.org/obo/ENVO_00000446 terrestrial biome http://purl.obolibrary.org/obo/ENVO_00002018 sewage http://purl.obolibrary.org/obo/ENVO_00002001 waste water http://purl.obolibrary.org/obo/ENVO_00002193 pulp-bleaching waste water http://purl.obolibrary.org/obo/ENVO_00002001 waste water http://purl.obolibrary.org/obo/ENVO_00003064 drinking water http://purl.obolibrary.org/obo/ENVO_00002011 fresh water http://purl.obolibrary.org/obo/ENVO_01000248 dense settlement biome http://purl.obolibrary.org/obo/ENVO_01000219 anthropogenic terrestrial biome http://purl.obolibrary.org/obo/ENVO_01000249 urban biome http://purl.obolibrary.org/obo/ENVO_01000248 dense settlement biome http://purl.obolibrary.org/obo/ENVO_01000655 explosive eruption http://purl.obolibrary.org/obo/ENVO_01000634 volcanic eruption http://purl.obolibrary.org/obo/ENVO_01000656 effusive eruption http://purl.obolibrary.org/obo/ENVO_01000634 volcanic eruption http://purl.obolibrary.org/obo/ENVO_01000678 tectonic earthquake http://purl.obolibrary.org/obo/ENVO_01000677 earthquake http://purl.obolibrary.org/obo/ENVO_01000679 megathrust earthquake http://purl.obolibrary.org/obo/ENVO_01000678 tectonic earthquake http://purl.obolibrary.org/obo/ENVO_01000715 metotsunami http://purl.obolibrary.org/obo/ENVO_01000689 tsunami http://purl.obolibrary.org/obo/ENVO_01000692 landslide process http://purl.obolibrary.org/obo/ENVO_01000690 mass wasting http://purl.obolibrary.org/obo/ENVO_01000693 rockfall http://purl.obolibrary.org/obo/ENVO_01000690 mass wasting http://purl.obolibrary.org/obo/ENVO_01000695 mudslide http://purl.obolibrary.org/obo/ENVO_01000690 mass wasting http://purl.obolibrary.org/obo/ENVO_01000696 mass wasting flow http://purl.obolibrary.org/obo/ENVO_01000690 mass wasting http://purl.obolibrary.org/obo/ENVO_01000700 sturzstrom http://purl.obolibrary.org/obo/ENVO_01000692 landslide process http://purl.obolibrary.org/obo/ENVO_01000691 avalanche http://purl.obolibrary.org/obo/ENVO_01000696 mass wasting flow http://purl.obolibrary.org/obo/ENVO_01000697 mudflow http://purl.obolibrary.org/obo/ENVO_01000696 mass wasting flow http://purl.obolibrary.org/obo/ENVO_01000698 debris flow http://purl.obolibrary.org/obo/ENVO_01000696 mass wasting flow http://purl.obolibrary.org/obo/ENVO_01000699 lahar http://purl.obolibrary.org/obo/ENVO_01000697 mudflow http://purl.obolibrary.org/obo/ENVO_01000716 storm surge process http://purl.obolibrary.org/obo/ENVO_01000707 coastal flooding http://purl.obolibrary.org/obo/ENVO_01000711 coastal flood http://purl.obolibrary.org/obo/ENVO_01000710 flood http://purl.obolibrary.org/obo/ENVO_01000712 riverine flood http://purl.obolibrary.org/obo/ENVO_01000710 flood http://purl.obolibrary.org/obo/ENVO_01000713 flash flood http://purl.obolibrary.org/obo/ENVO_01000710 flood http://purl.obolibrary.org/obo/ENVO_01000714 storm surge http://purl.obolibrary.org/obo/ENVO_01000711 coastal flood http://purl.obolibrary.org/obo/ENVO_01000707 coastal flooding http://purl.obolibrary.org/obo/ENVO_02500002 flooding http://purl.obolibrary.org/obo/ENVO_01000708 riverine flooding http://purl.obolibrary.org/obo/ENVO_02500002 flooding http://purl.obolibrary.org/obo/ENVO_01000709 flash flooding http://purl.obolibrary.org/obo/ENVO_02500002 flooding http://purl.obolibrary.org/obo/ENVO_01000717 areal flooding http://purl.obolibrary.org/obo/ENVO_02500002 flooding http://purl.obolibrary.org/obo/ENVO_01000718 urban flooding http://purl.obolibrary.org/obo/ENVO_02500002 flooding http://purl.obolibrary.org/obo/ENVO_02500017 anthropogenic reforestation http://purl.obolibrary.org/obo/ENVO_02500027 anthropogenic environmental process http://purl.obolibrary.org/obo/ENVO_02500013 reforestation http://purl.obolibrary.org/obo/ENVO_02500032 revegetation http://purl.obolibrary.org/obo/MP_0013015 obsolete abnormal CD4-positive, alpha beta T cell number aberrant number of T cells that expresses an alpha-beta T cell receptor complex and the CD4 coreceptor but not NK cell markers http://purl.obolibrary.org/obo/MP_0013016 obsolete increased CD4-positive, alpha beta T cell number reduced number of T cells that expresses an alpha-beta T cell receptor complex and the CD4 coreceptor but not NK cell markers http://purl.obolibrary.org/obo/MP_0013017 obsolete decreased CD4-positive, alpha beta T cell number increased number of T cells that expresses an alpha-beta T cell receptor complex and the CD4 coreceptor but not NK cell markers http://purl.obolibrary.org/obo/MP_0013018 obsolete abnormal CD8-positive alpha beta T cell number aberrant number of T cells that expresses an alpha-beta T cell receptor complex and the CD8 coreceptor but not NK cell markers http://purl.obolibrary.org/obo/MP_0013019 obsolete increased CD8-positive, alpha beta T cell number greater number of T cells that expresses an alpha-beta T cell receptor complex and the CD8 coreceptor but not NK cell markers http://purl.obolibrary.org/obo/MP_0013020 obsolete decreased CD8-positive, alpha beta T cell number reduced number of T cells that expresses an alpha-beta T cell receptor complex and the CD8 coreceptor but not NK cell markers http://purl.obolibrary.org/obo/MP_0013204 obsolete abnormal motile primary cilium morphology any structural anomaly of a primary cilium which may contain a variable array of axonemal microtubules and also contains molecular motors; motile primary cilia display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization http://purl.obolibrary.org/obo/MP_0013212 obsolete abnormal motile primary cilium physiology any functional anomaly of a primary cilium which may contain a variable array of axonemal microtubules and also contains molecular motors; motile primary cilia display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization http://purl.obolibrary.org/obo/MP_0020004 obsolete abnormal sulfatide level anomaly in the concentration of the sulfolipids that contribute to myelin function and stability http://purl.obolibrary.org/obo/MP_0020121 obsolete abnormal tyrosine 3-monooxygenase activity anomaly in the ability to catalyze the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O http://purl.obolibrary.org/obo/MP_0020122 obsolete decreased tyrosine 3-monooxygenase activity decreased ability to catalyze the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O http://purl.obolibrary.org/obo/MP_0020123 obsolete increased tyrosine 3-monooxygenase activity increased ability to catalyze the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O http://purl.obolibrary.org/obo/MP_0020181 obsolete abnormal body weight anomaly in the average weight compared to the control http://purl.obolibrary.org/obo/MP_0020195 obsolete increased sulphatide level increased concentrations of sulfatides, a class of sulfated galactosylceramides, in the body http://purl.obolibrary.org/obo/MP_0020196 obsolete decreased sulphatide level decreased concentrations of sulfatides, a class of sulfated galactosylceramides, in the body http://purl.obolibrary.org/obo/MP_3000002 obsolete abnormal skull morphology Any structural anomaly of a skull. http://purl.obolibrary.org/obo/MP_0000001 mammalian phenotype the observable morphological, physiological, behavioral and other characteristics of mammalian organisms that are manifested through development and lifespan http://purl.obolibrary.org/obo/GO_0003674 molecular_function http://purl.obolibrary.org/obo/GO_0008150 biological_process http://purl.obolibrary.org/obo/ENVO_02500000 environmental system process http://purl.obolibrary.org/obo/RO_0002213 positively_regulates http://purl.obolibrary.org/obo/RO_0002211 regulates http://purl.obolibrary.org/obo/BFO_0000051 has_part http://purl.obolibrary.org/obo/BFO_0000050 part_of http://purl.obolibrary.org/obo/BFO_0000066 occurs in http://purl.obolibrary.org/obo/RO_0002211 regulates http://purl.obolibrary.org/obo/chebi#has_part has part