Term IRI Term label Parent term IRI Parent term label Alternative term Definition http://purl.obolibrary.org/obo/CIDO_0000394 chemical modulates protein http://purl.obolibrary.org/obo/CIDO_0000118 chemical has protein target chemical has protein target as modulator An object property that represents a relation between a chemical entity and a protein where the chemical entity can target the protein as a modulator. Note that the chemical entity is usually an active compound of a corresponding drug. http://purl.obolibrary.org/obo/CIDO_0000411 chemical stimulates protein http://purl.obolibrary.org/obo/CIDO_0000118 chemical has protein target chemical has protein target as stimulator An object property that represents a relation between a chemical entity and a protein where the chemical entity can target the protein as a stimulator. Note that the chemical entity is usually an active compound of a corresponding drug. http://purl.obolibrary.org/obo/RO_0000052 characteristic of http://purl.obolibrary.org/obo/RO_0002314 characteristic of part of inheres_in a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence. http://purl.obolibrary.org/obo/RO_0000079 function of http://purl.obolibrary.org/obo/RO_0000052 characteristic of is function of a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0000085 has function http://purl.obolibrary.org/obo/RO_0000053 has characteristic has_function a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0000086 has quality http://purl.obolibrary.org/obo/RO_0000053 has characteristic has_quality a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/CIDO_0000119 chemical inhibits protein http://purl.obolibrary.org/obo/CIDO_0000118 chemical has protein target chemical has protein target as inhibitor An object property that represents a relation between a chemical entity and a protein where the chemical entity can target the protein as an enzyme inhibitor. Note that the chemical entity is usually an active compound of a corresponding drug. http://purl.obolibrary.org/obo/CIDO_0000122 chemical binds protein http://purl.obolibrary.org/obo/CIDO_0000118 chemical has protein target chemical has protein target as binder An object property that represents a relation between a chemical entity and a protein where the chemical entity can target the protein as an binder that chemically binds to the targeted protein. Note that the chemical entity is usually an active compound of a corresponding drug. http://purl.obolibrary.org/obo/CIDO_0000123 chemical induces protein http://purl.obolibrary.org/obo/CIDO_0000118 chemical has protein target chemical has protein target as inducer An object property that represents a relation between a chemical entity and a protein where the chemical entity can target the protein as an enzyme inducer. Note that the chemical entity is usually an active compound of a corresponding drug. An enzyme inducer is a type of chemical that increases the metabolic activity of an enzyme either by binding to the enzyme and activating it, or by increasing the expression of the gene coding for the enzyme. http://purl.obolibrary.org/obo/CIDO_0000126 chemical activates protein http://purl.obolibrary.org/obo/CIDO_0000118 chemical has protein target chemical has protein target as activator An object property that represents a relation between a chemical entity and a protein where the chemical entity can target the protein as an enzyme activator. Note that the chemical entity is usually an active compound of a corresponding drug. An enzyme inducer is a type of drug or chemcial that increases the metabolic activity of an enzyme either by binding to the enzyme and activating it, or by increasing the expression of the gene coding for the enzyme. http://purl.obolibrary.org/obo/BFO_0000051 has_part http://purl.obolibrary.org/obo/RO_0002131 overlaps has_part a core relation that holds between a whole and its part http://purl.obolibrary.org/obo/RO_0000087 has role http://purl.obolibrary.org/obo/RO_0000053 has characteristic has_role a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0002327 enables http://purl.obolibrary.org/obo/RO_0002215 capable of is executing c enables p iff c is capable of p and c acts to execute p. http://purl.obolibrary.org/obo/RO_0002409 indirectly negatively regulates http://purl.obolibrary.org/obo/RO_0012012 indirectly regulates indirectly inhibits p indirectly negatively regulates q iff p is indirectly causally upstream of q and p negatively regulates q. http://purl.obolibrary.org/obo/RO_0002436 molecularly interacts with http://purl.obolibrary.org/obo/RO_0002434 interacts with molecularly binds with An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other. http://purl.obolibrary.org/obo/RO_0002449 directly negatively regulates activity of http://purl.obolibrary.org/obo/RO_0002448 directly regulates activity of directly inhibits The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B. http://purl.obolibrary.org/obo/RO_0003305 contributes to severity of condition http://purl.obolibrary.org/obo/RO_0003304 contributes to condition contributes to expressivity of condition A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity influences the severity with which a condition manifests in an individual. http://purl.obolibrary.org/obo/RO_0003306 contributes to frequency of condition http://purl.obolibrary.org/obo/RO_0003304 contributes to condition contributes to penetrance of condition A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity influences the frequency of the condition in a population. http://purl.obolibrary.org/obo/RO_0003307 ameliorates condition http://purl.obolibrary.org/obo/RO_0003305 contributes to severity of condition is preventative for condition A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the presence of the entity reduces or eliminates some or all aspects of the condition. http://purl.obolibrary.org/obo/RO_0011013 indirectly positively regulates activity of http://purl.obolibrary.org/obo/RO_0011004 indirectly regulates activity of indirectly activates The entity A is not immediately upstream of the entity B and has an activity that up-regulates an activity performed by B. http://purl.obolibrary.org/obo/RO_0011016 indirectly negatively regulates activity of http://purl.obolibrary.org/obo/RO_0011004 indirectly regulates activity of indirectly inhibits The entity A is not immediately upstream of the entity B and has an activity that down-regulates an activity performed by B. http://purl.obolibrary.org/obo/BFO_0000062 preceded by http://purl.obolibrary.org/obo/RO_0002086 ends after preceded_by x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. http://purl.obolibrary.org/obo/RO_0000081 role of http://purl.obolibrary.org/obo/RO_0000052 characteristic of role_of a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/BFO_0000050 part_of http://purl.obolibrary.org/obo/RO_0002131 overlaps part_of a core relation that holds between a part and its whole http://purl.obolibrary.org/obo/RO_0002314 characteristic of part of http://purl.obolibrary.org/obo/RO_0002502 depends on inheres in part of q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w. http://purl.obolibrary.org/obo/RO_0002215 capable of http://purl.obolibrary.org/obo/RO_0002216 capable of part of has function realized in A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. http://purl.obolibrary.org/obo/RO_0002331 involved in http://purl.obolibrary.org/obo/RO_0002431 involved in or involved in regulation of enables part of c involved_in p if and only if c enables some process p', and p' is part of p http://purl.obolibrary.org/obo/RO_0002431 involved in or involved in regulation of http://purl.obolibrary.org/obo/RO_0002500 causal agent in process involved in or reguates c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p http://purl.obolibrary.org/obo/RO_0002216 capable of part of http://purl.obolibrary.org/obo/RO_0002500 causal agent in process has function in c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p. http://purl.obolibrary.org/obo/RO_0002329 part of structure that is capable of http://purl.obolibrary.org/obo/RO_0002328 functionally related to 0 this relation holds between c and p when c is part of some c', and c' is capable of p. http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within http://purl.obolibrary.org/obo/RO_0002501 causal relation between processes influences (processual) p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q. http://purl.obolibrary.org/obo/RO_0002407 indirectly positively regulates http://purl.obolibrary.org/obo/RO_0012012 indirectly regulates indirectly activates p indirectly positively regulates q iff p is indirectly causally upstream of q and p positively regulates q. http://purl.obolibrary.org/obo/RO_0002413 provides input for http://purl.obolibrary.org/obo/RO_0002414 transitively provides input for directly provides input for p provides input for q iff p is immediately causally upstream of q, and there exists some c such that p has_output c and q has_input c. http://purl.obolibrary.org/obo/RO_0002450 directly positively regulates activity of http://purl.obolibrary.org/obo/RO_0002448 directly regulates activity of directly activates The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B. http://purl.obolibrary.org/obo/RO_0002599 capable of inhibiting or preventing pathological process http://purl.obolibrary.org/obo/RO_0002597 capable of negatively regulating treats Holds between a material entity c and a pathological process p if and only if c is capable of some activity a, where a inhibits p. http://purl.obolibrary.org/obo/RO_0002600 capable of upregulating or causing pathological process http://purl.obolibrary.org/obo/RO_0002598 capable of positively regulating causes disease Holds between a material entity c and a pathological process p if and only if c is capable of some activity a, where a negatively regulates p. http://purl.obolibrary.org/obo/RO_0002606 is substance that treats http://purl.obolibrary.org/obo/RO_0002599 capable of inhibiting or preventing pathological process treats c is a substance that treats d if c is a material entity (such as a small molecule or compound) and d is a pathological process, phenotype or disease, and c is capable of some activity that negative regulates or decreases the magnitude of d. http://purl.obolibrary.org/obo/RO_0004028 realized in response to stimulus http://purl.obolibrary.org/obo/RO_0002410 causally related to A relationship between a realizable entity R (e.g. function or disposition) and a material entity M where R is realized in response to a process that has an input stimulus of M. http://purl.obolibrary.org/obo/RO_0004030 disease arises from alteration in structure http://purl.obolibrary.org/obo/RO_0004019 disease has basis in A relationship between a disease and an anatomical structure where the material basis of the disease is some pathological change in the structure. Anatomical structure includes cellular and sub-cellular entities, such as chromosome and organelles. http://purl.obolibrary.org/obo/BFO_0000138 proper part of occurrent http://purl.obolibrary.org/obo/BFO_0000132 part of occurrent b proper_occurrent_part_of c =Def. b occurrent_part_of c & b and c are not identical. (axiom label in BFO2 Reference: [005-001]) http://purl.obolibrary.org/obo/BFO_0000139 temporal part of http://purl.obolibrary.org/obo/BFO_0000132 part of occurrent b temporal_part_of c =Def.b occurrent_part_of c & & for some temporal region t, b occupies_temporal_region t & for all occurrents d, t (if d occupies_temporal_region t & t? occurrent_part_of t then (d occurrent_part_of a iff d occurrent_part_of b)). (axiom label in BFO2 Reference: [078-003]) http://purl.obolibrary.org/obo/BFO_0000158 bearer of at all times http://purl.obolibrary.org/obo/BFO_0000168 has specific dependent at all times b bearer_of c at t =Def. c s-depends_on b at t & b is an independent continuant that is not a spatial region. (axiom label in BFO2 Reference: [053-004]) http://purl.obolibrary.org/obo/RO_0004020 disease has basis in dysfunction of http://purl.obolibrary.org/obo/RO_0004019 disease has basis in A relation that holds between the disease and a material entity where the physical basis of the disease is a disorder of that material entity that affects its function. http://purl.obolibrary.org/obo/RO_0004021 disease has basis in disruption of http://purl.obolibrary.org/obo/RO_0004019 disease has basis in A relation that holds between the disease and a process where the physical basis of the disease disrupts execution of a key biological process. http://purl.obolibrary.org/obo/RO_0004022 disease has basis in feature http://purl.obolibrary.org/obo/RO_0004019 disease has basis in A relation that holds between the disease and a feature (a phenotype or other disease) where the physical basis of the disease is the feature. http://purl.obolibrary.org/obo/RO_0004024 disease causes disruption of http://purl.obolibrary.org/obo/RO_0004023 causal relationship with disease as subject A relationship between a disease and a process where the disease process disrupts the execution of the process. http://purl.obolibrary.org/obo/CIDO_0000408 chemical has protein target as negative modulator http://purl.obolibrary.org/obo/CIDO_0000394 chemical modulates protein An object property that represents a relation between a chemical entity and a protein where the chemical entity can target the protein as a negative modulator. Note that the chemical entity is usually an active compound of a corresponding drug. http://purl.obolibrary.org/obo/BFO_0000063 precedes http://purl.obolibrary.org/obo/RO_0002222 temporally related to x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. http://purl.obolibrary.org/obo/IAO_0000039 has measurement unit label http://purl.obolibrary.org/obo/BFO_0000051 has_part A relation between a value specification and its unit of measurement. http://purl.obolibrary.org/obo/OBI_0000293 has_specified_input http://purl.obolibrary.org/obo/RO_0000057 has_participant The inverse property of is_specified_input_of http://purl.obolibrary.org/obo/OBI_0000295 is_specified_input_of http://purl.obolibrary.org/obo/RO_0000056 participates in A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of. http://purl.obolibrary.org/obo/OBI_0000299 has_specified_output http://purl.obolibrary.org/obo/RO_0000057 has_participant The inverse property of is_specified_output_of http://purl.obolibrary.org/obo/OBI_0000312 is_specified_output_of http://purl.obolibrary.org/obo/RO_0000056 participates in A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of. http://purl.obolibrary.org/obo/OBI_0000643 has grain http://purl.obolibrary.org/obo/BFO_0000051 has_part the relation of the cells in the finger of the skin to the finger, in which an indeterminate number of grains are parts of the whole by virtue of being grains in a collective that is part of the whole, and in which removing one granular part does not nec- essarily damage or diminish the whole. Ontological Whether there is a fixed, or nearly fixed number of parts - e.g. fingers of the hand, chambers of the heart, or wheels of a car - such that there can be a notion of a single one being missing, or whether, by contrast, the number of parts is indeterminate - e.g., cells in the skin of the hand, red cells in blood, or rubber molecules in the tread of the tire of the wheel of the car. http://purl.obolibrary.org/obo/OBI_0001938 has value specification http://purl.obolibrary.org/obo/BFO_0000051 has_part A relation between an information content entity and a value specification that specifies its value. http://purl.obolibrary.org/obo/RO_0002219 surrounded by http://purl.obolibrary.org/obo/RO_0002220 adjacent to x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x http://purl.obolibrary.org/obo/RO_0002220 adjacent to http://purl.obolibrary.org/obo/RO_0002163 spatially disjoint from x adjacent to y if and only if x and y share a boundary. http://purl.obolibrary.org/obo/RO_0002351 has member http://purl.obolibrary.org/obo/BFO_0000051 has_part has member is a mereological relation between a collection and an item. http://purl.obolibrary.org/obo/RO_0002018 has component process http://purl.obolibrary.org/obo/RO_0002180 has component w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type. http://purl.obolibrary.org/obo/RO_0019000 regulates characteristic http://purl.obolibrary.org/obo/RO_0002410 causally related to A relationship that holds between a process and a characteristic in which process (P) regulates characteristic (C) iff: P results in the existence of C OR affects the intensity or magnitude of C. http://purl.obolibrary.org/obo/RO_0019001 positively regulates characteristic http://purl.obolibrary.org/obo/RO_0019000 regulates characteristic A relationship that holds between a process and a characteristic in which process (P) positively regulates characteristic (C) iff: P results in an increase in the intensity or magnitude of C. http://purl.obolibrary.org/obo/RO_0019002 negatively regulates characteristic http://purl.obolibrary.org/obo/RO_0019000 regulates characteristic A relationship that holds between a process and a characteristic in which process (P) negatively regulates characteristic (C) iff: P results in a decrease in the intensity or magnitude of C. http://purl.obolibrary.org/obo/RO_0019501 confers susceptibility to condition http://purl.obolibrary.org/obo/RO_0003304 contributes to condition Relates a gene to condition, such that a variation in this gene predisposes to the development of a condition. http://purl.obolibrary.org/obo/RO_0001020 is allergic trigger for http://purl.obolibrary.org/obo/RO_0003302 causes or contributes to condition A relation between a material entity and a condition (a phenotype or disease) of a host, in which the material entity is not part of the host, and is considered harmless to non-allergic hosts, and the condition results in pathological processes that include an abnormally strong immune response against the material entity. http://purl.obolibrary.org/obo/RO_0001021 is autoimmune trigger for http://purl.obolibrary.org/obo/RO_0003302 causes or contributes to condition A relation between a material entity and a condition (a phenotype or disease) of a host, in which the material entity is part of the host itself, and the condition results in pathological processes that include an abnormally strong immune response against the material entity. http://purl.obolibrary.org/obo/RO_0002200 has phenotype http://purl.obolibrary.org/obo/RO_0016001 has phenotype or disease A relationship that holds between a biological entity and a phenotype. Here a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). The subject of this relationship can be an organism (where the organism has the phenotype, i.e. the qualities inhere in parts of this organism), a genomic entity such as a gene or genotype (if modifications of the gene or the genotype causes the phenotype), or a condition such as a disease (such that if the condition inheres in an organism, then the organism has the phenotype). http://purl.obolibrary.org/obo/RO_0003304 contributes to condition http://purl.obolibrary.org/obo/RO_0003302 causes or contributes to condition A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some contributing role that influences the condition. http://purl.obolibrary.org/obo/OGG_0000000014 is genome of organism http://purl.obolibrary.org/obo/BFO_0000050 part_of a 'part of continuant at some time' relation that incides a genome belongs to a organism. http://purl.obolibrary.org/obo/OGG_0000000016 is gene of organism http://purl.obolibrary.org/obo/BFO_0000050 part_of a relation between a gene and the organism where this gene belongs to the organism in nature. It does not include a foreign gene that is transferred to an organism by a genetic engineering method. http://purl.obolibrary.org/obo/RO_0002309 has exposure stimulus http://purl.obolibrary.org/obo/RO_0002244 related via exposure to A relationship between an exposure event or process and any agent, stimulus, activity, or event that causally effects an organism and interacts with an exposure receptor during an exposure event. http://purl.obolibrary.org/obo/CIDO_0000045 chemical degrades protein http://purl.obolibrary.org/obo/CIDO_0000118 chemical has protein target An object property that represents a relation between a chemical entity and a protein where the chemical entity can degrate the protein. http://purl.obolibrary.org/obo/CIDO_0000061 has binding participant http://purl.obolibrary.org/obo/RO_0000057 has_participant An object property between a binding process and a paritipant where the participant is one input of the binding process. http://purl.obolibrary.org/obo/CIDO_0000120 chemical has protein target as antagonist http://purl.obolibrary.org/obo/CIDO_0000118 chemical has protein target An object property that represents a relation between a chemical entity and a protein where the chemical entity can target the protein as an receptor antagonist. Note that the chemical entity is usually an active compound of a corresponding drug. http://purl.obolibrary.org/obo/CIDO_0000121 chemical has protein target as agonist http://purl.obolibrary.org/obo/CIDO_0000118 chemical has protein target An object property that represents a relation between a chemical entity and a protein where the chemical entity can target the protein as an receptor agonist. Note that the chemical entity is usually an active compound of a corresponding drug. An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response. http://purl.obolibrary.org/obo/CIDO_0000125 chemical has protein target as potentiator http://purl.obolibrary.org/obo/CIDO_0000118 chemical has protein target An object property that represents a relation between a chemical entity and a protein where the chemical entity can target the protein as a potentiator. Note that the chemical entity is usually an active compound of a corresponding drug. In clinical pharmacology, a potentiator is a drug, herb, or chemical that intensifies the effects of a given drug or protein regulator. http://purl.obolibrary.org/obo/CIDO_0000127 drug has protein target as agonist http://purl.obolibrary.org/obo/CIDO_0000124 drug has protein target An object property that represents a relation between a drug and a protein where the drug can target the protein as an receptor agonist. An agonist is a drug that binds to a receptor and activates the receptor to produce a biological response. http://purl.obolibrary.org/obo/CIDO_0000128 drug has protein target as antagonist http://purl.obolibrary.org/obo/CIDO_0000124 drug has protein target An object property that represents a relation between a drug and a protein where the drug can target the protein as an receptor antagonist. http://purl.obolibrary.org/obo/CIDO_0000129 drug has protein target as binder http://purl.obolibrary.org/obo/CIDO_0000124 drug has protein target An object property that represents a relation between a drug and a protein where the drug can target the protein as an binder that chemically binds to the targeted protein. http://purl.obolibrary.org/obo/CIDO_0000130 drug has protein target as inducer http://purl.obolibrary.org/obo/CIDO_0000124 drug has protein target An object property that represents a relation between a drug and a protein where the drug can target the protein as an enzyme inducer. An enzyme inducer is a type of chemical that increases the metabolic activity of an enzyme either by binding to the enzyme and activating it, or by increasing the expression of the gene coding for the enzyme. http://purl.obolibrary.org/obo/CIDO_0000131 drug has protein target as inhibitor http://purl.obolibrary.org/obo/CIDO_0000124 drug has protein target An object property that represents a relation between a drug and a protein where the drug can target the protein as an enzyme inhibitor. http://purl.obolibrary.org/obo/CIDO_0000132 drug has protein target as potentiator http://purl.obolibrary.org/obo/CIDO_0000124 drug has protein target An object property that represents a relation between a drug and a protein where the drug can target the protein as a potentiator. In clinical pharmacology, a potentiator is a drug, herb, or chemical that intensifies the effects of a given drug or protein regulator. http://purl.obolibrary.org/obo/CIDO_0000133 drug has protein target as activator http://purl.obolibrary.org/obo/CIDO_0000124 drug has protein target An object property that represents a relation between a drug and a protein where the drug can target the protein as an enzyme activator.An enzyme inducer is a type of drug or chemcial that increases the metabolic activity of an enzyme either by binding to the enzyme and activating it, or by increasing the expression of the gene coding for the enzyme. http://purl.obolibrary.org/obo/CIDO_0000140 chemical inhibits in vivo replication of virus http://purl.obolibrary.org/obo/CIDO_0000150 chemical inhibits replication of virus An object property that represents a relation between a chemical entity and a virus where the chemical has an effective role against viral replication in vivo http://purl.obolibrary.org/obo/CIDO_0000141 chemical effective in vitro against virus http://purl.obolibrary.org/obo/CIDO_0000139 chemical effective against virus An object property that represents a relation between a chemical entity and a virus where the chemical has an effective role against viral infection in vitro http://purl.obolibrary.org/obo/CIDO_0000142 chemical effective in vivo against virus http://purl.obolibrary.org/obo/CIDO_0000139 chemical effective against virus An object property that represents a relation between a chemical entity and a virus where the chemical has an effective role against viral infection in vivo http://purl.obolibrary.org/obo/CIDO_0000143 chemical inhibits in vivo invasion of virus http://purl.obolibrary.org/obo/CIDO_0000149 chemical inhibits invasion of virus An object property that represents a relation between a chemical entity and a virus where the chemical has an effective role against viral invasion in vivo http://purl.obolibrary.org/obo/CIDO_0000144 chemical inhibits in vitro replication of virus http://purl.obolibrary.org/obo/CIDO_0000150 chemical inhibits replication of virus An object property that represents a relation between a chemical entity and a virus where the chemical has an effective role against viral replication in vitro http://purl.obolibrary.org/obo/CIDO_0000145 chemical inhibits in vitro invasion of virus http://purl.obolibrary.org/obo/CIDO_0000149 chemical inhibits invasion of virus An object property that represents a relation between a chemical entity and a virus where the chemical has an effective role against viral invasion in vitro http://purl.obolibrary.org/obo/CIDO_0000146 chemical modulates response against virus http://purl.obolibrary.org/obo/CIDO_0000139 chemical effective against virus An object property that represents a relation between a chemical entity and a virus where the chemical has an effective role in modulating host response against virual infection http://purl.obolibrary.org/obo/CIDO_0000147 chemical modulates response in vivo against virus http://purl.obolibrary.org/obo/CIDO_0000146 chemical modulates response against virus An object property that represents a relation between a chemical entity and a virus where the chemical has an effective role in modulating host response against viral infection in vivo http://purl.obolibrary.org/obo/CIDO_0000148 chemical modulates response in vitro against virus http://purl.obolibrary.org/obo/CIDO_0000146 chemical modulates response against virus An object property that represents a relation between a chemical entity and a virus where the chemical has an effective role in modulating host response against viral infection in vitro http://purl.obolibrary.org/obo/CIDO_0000149 chemical inhibits invasion of virus http://purl.obolibrary.org/obo/CIDO_0000139 chemical effective against virus An object property that represents a relation between a chemical entity and a virus where the chemical has an effective role against virual invasion http://purl.obolibrary.org/obo/CIDO_0000150 chemical inhibits replication of virus http://purl.obolibrary.org/obo/CIDO_0000139 chemical effective against virus An object property that represents a relation between a chemical entity and a virus where the chemical has an effective role against virual replication http://purl.obolibrary.org/obo/RO_0002404 causally downstream of http://purl.obolibrary.org/obo/RO_0002427 causally downstream of or within inverse of upstream of http://purl.obolibrary.org/obo/RO_0002412 immediately causally upstream of http://purl.obolibrary.org/obo/RO_0002411 causally upstream of p is immediately causally upstream of q iff p is causally upstream of q, and the end of p is coincident with the beginning of q. http://purl.obolibrary.org/obo/RO_0002448 directly regulates activity of http://purl.obolibrary.org/obo/RO_0011002 regulates activity of The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B. A and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B. http://purl.obolibrary.org/obo/RO_0002566 causally influences http://purl.obolibrary.org/obo/RO_0002506 causal relation between entities The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size). http://purl.obolibrary.org/obo/RO_0003302 causes or contributes to condition http://purl.obolibrary.org/obo/RO_0002410 causally related to A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal or contributing role that influences the condition. http://purl.obolibrary.org/obo/RO_0003303 causes condition http://purl.obolibrary.org/obo/RO_0003302 causes or contributes to condition A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal role for the condition. http://purl.obolibrary.org/obo/BFO_0000187 has continuant part at all times that part exists http://purl.obolibrary.org/obo/BFO_0000178 has continuant part at some time forall(t) exists_at(y,t) -> exists_at(x,t) and 'has continuant part'(x,y,t) http://purl.obolibrary.org/obo/VO_0000530 has vaccine vector http://purl.obolibrary.org/obo/VO_0000520 has vaccine component A type of 'has vaccine component' relation that is specifically for vaccine vector component http://purl.obolibrary.org/obo/RO_0001022 has allergic trigger http://purl.obolibrary.org/obo/RO_0003302 causes or contributes to condition A relation between a condition (a phenotype or disease) of a host and a material entity, in which the material entity is not part of the host, and is considered harmless to non-allergic hosts, and the condition results in pathological processes that include an abnormally strong immune response against the material entity. http://purl.obolibrary.org/obo/RO_0001023 has autoimmune trigger http://purl.obolibrary.org/obo/RO_0003302 causes or contributes to condition A relation between a condition (a phenotype or disease) of a host and a material entity, in which the material entity is part of the host itself, and the condition results in pathological processes that include an abnormally strong immune response against the material entity. http://purl.obolibrary.org/obo/RO_0002012 occurrent part of http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within A part of relation that applies only between occurrents. http://purl.obolibrary.org/obo/RO_0002240 has exposure receptor http://purl.obolibrary.org/obo/RO_0002244 related via exposure to A broad relationship between an exposure event or process and any entity (e.g., an organism, organism population, or an organism part) that interacts with an exposure stimulus during the exposure event. http://purl.obolibrary.org/obo/RO_0002241 has exposure stressor http://purl.obolibrary.org/obo/RO_0002309 has exposure stimulus A broad relationship between an exposure event or process and any agent, stimulus, activity, or event that causes stress or tension on an organism and interacts with an exposure receptor during an exposure event. http://purl.obolibrary.org/obo/RO_0002242 has exposure route http://purl.obolibrary.org/obo/RO_0002244 related via exposure to A broad relationship between an exposure event or process and a process by which the exposure stressor comes into contact with the exposure receptor http://purl.obolibrary.org/obo/RO_0002243 has exposure transport path http://purl.obolibrary.org/obo/RO_0002244 related via exposure to A broad relationship between an exposure event or process and the course takes from the source to the target. http://purl.obolibrary.org/obo/RO_0002244 related via exposure to http://purl.obolibrary.org/obo/RO_0002410 causally related to Any relationship between an exposure event or process and any other entity. http://purl.obolibrary.org/obo/RO_0002263 acts upstream of http://purl.obolibrary.org/obo/RO_0002264 acts upstream of or within c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes. http://purl.obolibrary.org/obo/RO_0002302 is treated by substance http://purl.obolibrary.org/obo/RO_0002410 causally related to Inverse of 'is substance that treats' http://purl.obolibrary.org/obo/RO_0002304 causally upstream of, positive effect http://purl.obolibrary.org/obo/RO_0004047 causally upstream of or within, positive effect p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q. http://purl.obolibrary.org/obo/RO_0002305 causally upstream of, negative effect http://purl.obolibrary.org/obo/RO_0004046 causally upstream of or within, negative effect p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q. http://purl.obolibrary.org/obo/CIDO_0000704 has characteristic AA mutation http://purl.obolibrary.org/obo/CIDO_0000608 has AA mutation An object property that defines a relation between a microbe variant and an AA mutation where the microbe (like SARS_CoV-2) variant has the AA mutation such that the microbe variant has an AA change that is used to identify a mircrobe variant. This is used over AA variant for deletions or nonsense mutations. http://purl.obolibrary.org/obo/CIDO_0000706 is characteristic AA mutation of http://purl.obolibrary.org/obo/CIDO_0000609 is AA mutation of An object property that defines a relation between a microbe variant and an AA mutation where the microbe (like SARS_CoV-2) variant has the AA mutation such that the microbe variant has an AA change that is used to identify a microbe variant. This is used over AA variant for deletions or nonsense mutations. http://purl.obolibrary.org/obo/RO_0002131 overlaps http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to x overlaps y if and only if there exists some z such that x has part z and z part of y http://purl.obolibrary.org/obo/BFO_0000052 inheres in at all times http://purl.obolibrary.org/obo/BFO_0000070 specifically depends on at all times b inheres_in c at t =Def. b is a dependent continuant & c is an independent continuant that is not a spatial region & b s-depends_on c at t. (axiom label in BFO2 Reference: [051-002]) http://purl.obolibrary.org/obo/RO_0011002 regulates activity of http://purl.obolibrary.org/obo/RO_0002566 causally influences The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B. http://purl.obolibrary.org/obo/RO_0011003 regulates quantity of http://purl.obolibrary.org/obo/RO_0002566 causally influences The entity A has an activity that regulates the quantity or abundance or concentration of the entity B. http://purl.obolibrary.org/obo/RO_0011004 indirectly regulates activity of http://purl.obolibrary.org/obo/RO_0011002 regulates activity of The entity A is not immediately upstream of the entity B but A has an activity that regulates an activity performed by B. http://purl.obolibrary.org/obo/RO_0011007 decreases by repression quantity of http://purl.obolibrary.org/obo/RO_0011023 indirectly negatively regulates quantity of The entity A has an activity that down-regulates by repression the quantity of B. The down-regulation is due to A having an effect on an intermediate entity (typically a DNA or mRNA element) which can produce B. For example, protein A (transcription factor) indirectly decreases by repression the quantity of protein B (gene product) if and only if A negatively regulates the process of transcription or translation of a nucleic acid element that produces B. http://purl.obolibrary.org/obo/RO_0011008 increases by expression quantity of http://purl.obolibrary.org/obo/RO_0011024 indirectly positively regulates quantity of The entity A has an activity that up-regulates by expression the quantity of B. The up-regulation is due to A having an effect on an intermediate entity (typically a DNA or mRNA element) which can produce B. For example, protein A (transcription factor) indirectly increases by expression the quantity of protein B (gene product) if and only if A positively regulates the process of transcription or translation of a nucleic acid element that produces B. http://purl.obolibrary.org/obo/RO_0011009 directly positively regulates quantity of http://purl.obolibrary.org/obo/RO_0011021 directly regulates quantity of The entity A has an activity that directly positively regulates the quantity of B. http://purl.obolibrary.org/obo/RO_0011010 directly negatively regulates quantity of http://purl.obolibrary.org/obo/RO_0011021 directly regulates quantity of The entity A has an activity that directly negatively regulates the quantity of B. http://purl.obolibrary.org/obo/RO_0011014 destabilizes quantity of http://purl.obolibrary.org/obo/RO_0011010 directly negatively regulates quantity of An entity A directly interacts with B and A has an activity that decreases the amount of an entity B by degradating it. http://purl.obolibrary.org/obo/RO_0011015 stabilizes quantity of http://purl.obolibrary.org/obo/RO_0011009 directly positively regulates quantity of An entity A physically interacts with B and A has an activity that increases the amount of an entity B by stabilizing it. http://purl.obolibrary.org/obo/RO_0011021 directly regulates quantity of http://purl.obolibrary.org/obo/RO_0011003 regulates quantity of The entity A, immediately upstream of B, has an activity that directly regulates the quantity of B. http://purl.obolibrary.org/obo/RO_0011022 indirectly regulates quantity of http://purl.obolibrary.org/obo/RO_0011003 regulates quantity of The entity A is not immediately upstream of the entity B, but A has an activity that regulates the quantity or abundance or concentration of B. http://purl.obolibrary.org/obo/RO_0011023 indirectly negatively regulates quantity of http://purl.obolibrary.org/obo/RO_0011022 indirectly regulates quantity of The entity A does not physically interact with the entity B, and A has an activity that down-regulates the quantity or abundance or concentration of B. http://purl.obolibrary.org/obo/RO_0011024 indirectly positively regulates quantity of http://purl.obolibrary.org/obo/RO_0011022 indirectly regulates quantity of The entity A does not physically interact with the entity B, and A has an activity that up-regulates the quantity or abundance or concentration of B. http://purl.obolibrary.org/obo/RO_0012004 is small molecule regulator of http://purl.obolibrary.org/obo/RO_0002596 capable of regulating a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process http://purl.obolibrary.org/obo/RO_0012005 is small molecule activator of http://purl.obolibrary.org/obo/RO_0002598 capable of positively regulating a relation between a continuant and a process, in which the continuant is a small molecule that activates the process http://purl.obolibrary.org/obo/RO_0012006 is small molecule inhibitor of http://purl.obolibrary.org/obo/RO_0002597 capable of negatively regulating a relation between a continuant and a process, in which the continuant is a small molecule that inhibits the process http://purl.obolibrary.org/obo/RO_0002411 causally upstream of http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q. http://purl.obolibrary.org/obo/RO_0002211 regulates http://purl.obolibrary.org/obo/RO_0002411 causally upstream of p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q. http://purl.obolibrary.org/obo/RO_0002212 negatively regulates http://purl.obolibrary.org/obo/RO_0002211 regulates p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q. http://purl.obolibrary.org/obo/RO_0002213 positively regulates http://purl.obolibrary.org/obo/RO_0002211 regulates p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q. http://purl.obolibrary.org/obo/RO_0002180 has component http://purl.obolibrary.org/obo/BFO_0000051 has_part w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type. http://purl.obolibrary.org/obo/RO_0002163 spatially disjoint from http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to A is spatially_disjoint_from B if and only if they have no parts in common http://purl.obolibrary.org/obo/RO_0002473 composed primarily of http://purl.obolibrary.org/obo/BFO_0000051 has_part x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y. http://purl.obolibrary.org/obo/RO_0002023 directly negatively regulated by http://purl.obolibrary.org/obo/RO_0002022 directly regulated by Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1. http://purl.obolibrary.org/obo/RO_0002024 directly positively regulated by http://purl.obolibrary.org/obo/RO_0002022 directly regulated by Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1. http://purl.obolibrary.org/obo/CIDO_0000175 drug effective in vivo against virus http://purl.obolibrary.org/obo/CIDO_0000174 drug effective against virus An object property that represents a relation between a chemical entity and a virus where the chemical has an effective role against viral infection in vivo http://purl.obolibrary.org/obo/CIDO_0000219 disease induced by phenotype http://purl.obolibrary.org/obo/RO_0004023 causal relationship with disease as subject A causal relationship with disease as subject that shows that the realization of the disease is caused by a phenotype. http://purl.obolibrary.org/obo/BFO_0000162 has disposition at all times http://purl.obolibrary.org/obo/BFO_0000158 bearer of at all times a has_disposition b at t =Def. b disposition_of a at t. (axiom label in BFO2 Reference: [069-001]) http://purl.obolibrary.org/obo/RO_0012011 indirectly causally upstream of http://purl.obolibrary.org/obo/RO_0002411 causally upstream of p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q. http://purl.obolibrary.org/obo/RO_0012012 indirectly regulates http://purl.obolibrary.org/obo/RO_0012011 indirectly causally upstream of p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q. http://purl.obolibrary.org/obo/RO_0002264 acts upstream of or within http://purl.obolibrary.org/obo/RO_0002500 causal agent in process c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process. http://purl.obolibrary.org/obo/RO_0002507 determined by http://purl.obolibrary.org/obo/RO_0002559 causally influenced by s determined by f if and only if s is a type of system, and f is a material entity that is part of s, such that f exerts a strong causal influence on the functioning of s, and the removal of f would cause the collapse of s. http://purl.obolibrary.org/obo/RO_0003309 exacerbates condition http://purl.obolibrary.org/obo/RO_0003305 contributes to severity of condition A relationship between an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) and a condition (a phenotype or disease), where the presence of the entity worsens some or all aspects of the condition. http://purl.obolibrary.org/obo/RO_0003310 condition ameliorated by http://purl.obolibrary.org/obo/RO_0002410 causally related to A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are reduced or eliminated by the presence of the entity. http://purl.obolibrary.org/obo/RO_0003311 condition exacerbated by http://purl.obolibrary.org/obo/RO_0002410 causally related to A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are worsened by the presence of the entity. http://purl.obolibrary.org/obo/RO_0004011 is causal gain of function germline mutation of in http://purl.obolibrary.org/obo/RO_0004010 is genetic basis for condition Relates a gene to condition, such that a mutation in this gene in a germ cell provides a new function of the corresponding product and that is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]. http://purl.obolibrary.org/obo/RO_0004012 is causal loss of function germline mutation of in http://purl.obolibrary.org/obo/RO_0004010 is genetic basis for condition Relates a gene to condition, such that a mutation in this gene in a germ cell impairs the function of the corresponding product and that is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]. http://purl.obolibrary.org/obo/RO_0004013 is causal germline mutation in http://purl.obolibrary.org/obo/RO_0004010 is genetic basis for condition Relates a gene to condition, such that a mutation in this gene is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]. http://purl.obolibrary.org/obo/RO_0004014 is causal somatic mutation in http://purl.obolibrary.org/obo/RO_0004010 is genetic basis for condition Relates a gene to condition, such that a mutation in this gene is sufficient to produce the condition but that cannot be passed on to offspring[modified from orphanet]. http://purl.obolibrary.org/obo/RO_0004015 is causal susceptibility factor for http://purl.obolibrary.org/obo/RO_0004010 is genetic basis for condition Relates a gene to condition, such that a mutation in this gene predisposes to the development of a condition and that is necessary but not sufficient to develop the condition[modified from orphanet]. http://purl.obolibrary.org/obo/RO_0004016 is causal germline mutation partially giving rise to http://purl.obolibrary.org/obo/RO_0004010 is genetic basis for condition Relates a gene to condition, such that a mutation in this gene partially contributes to the presentation of this condition[modified from orphanet]. http://purl.obolibrary.org/obo/RO_0004034 acts upstream of, positive effect http://purl.obolibrary.org/obo/RO_0004032 acts upstream of or within, positive effect c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive http://purl.obolibrary.org/obo/RO_0004035 acts upstream of, negative effect http://purl.obolibrary.org/obo/RO_0004033 acts upstream of or within, negative effect c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative http://purl.obolibrary.org/obo/CIDO_0000269 has ligand http://purl.obolibrary.org/obo/RO_0000057 has_participant A subproperty of 'has participant' that represents a relation between a process and a participant where the participant has the ligand role. http://purl.obolibrary.org/obo/CIDO_0000270 has receptor http://purl.obolibrary.org/obo/RO_0000057 has_participant A subproperty of 'has participant' that represents a relation between a process and a participant where the participant has the receptor role. http://purl.obolibrary.org/obo/CIDO_0000281 has characteristic AA variant http://purl.obolibrary.org/obo/CIDO_0000603 has AA variant An object property that defines a relation between a microbe variant and an AA variant where the microbe (like SARS_CoV-2) variant has the AA variant such that the microbe variant changes its AA from a previous one to a new one. http://purl.obolibrary.org/obo/RO_0018027 is agonist of http://purl.obolibrary.org/obo/RO_0002450 directly positively regulates activity of a relation between a ligand (material entity) and a receptor (material entity) that implies the binding of the ligand to the receptor activates some activity of the receptor http://purl.obolibrary.org/obo/RO_0018028 is inverse agonist of http://purl.obolibrary.org/obo/RO_0002449 directly negatively regulates activity of a relation between a ligand (material entity) and a receptor (material entity) that implies the binding of the ligand to the receptor inhibits some activity of the receptor to below basal level http://purl.obolibrary.org/obo/RO_0018029 is antagonist of http://purl.obolibrary.org/obo/RO_0002449 directly negatively regulates activity of a relation between a ligand (material entity) and a receptor (material entity) that implies the binding of the ligand to the receptor reduces some activity of the receptor to basal level http://purl.obolibrary.org/obo/BFO_0000118 has proper occurrent part http://purl.obolibrary.org/obo/BFO_0000117 has occurrent part b has_proper_occurrent_part c = Def. c proper_occurrent_part_of b. [XXX-001 http://purl.obolibrary.org/obo/RO_0002334 regulated by http://purl.obolibrary.org/obo/RO_0002427 causally downstream of or within inverse of regulates http://purl.obolibrary.org/obo/RO_0002335 negatively regulated by http://purl.obolibrary.org/obo/RO_0002334 regulated by inverse of negatively regulates http://purl.obolibrary.org/obo/RO_0002336 positively regulated by http://purl.obolibrary.org/obo/RO_0002334 regulated by inverse of positively regulates http://purl.obolibrary.org/obo/RO_0002427 causally downstream of or within http://purl.obolibrary.org/obo/RO_0002501 causal relation between processes inverse of causally upstream of or within http://purl.obolibrary.org/obo/RO_0002500 causal agent in process http://purl.obolibrary.org/obo/RO_0002595 causal relation between material entity and a process A relationship between a material entity and a process where the material entity has some causal role that influences the process http://purl.obolibrary.org/obo/RO_0002501 causal relation between processes http://purl.obolibrary.org/obo/RO_0002410 causally related to p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q. http://purl.obolibrary.org/obo/RO_0002584 has part structure that is capable of http://purl.obolibrary.org/obo/RO_0002595 causal relation between material entity and a process s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p http://purl.obolibrary.org/obo/RO_0002595 causal relation between material entity and a process http://purl.obolibrary.org/obo/RO_0002410 causally related to A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity. http://purl.obolibrary.org/obo/RO_0002596 capable of regulating http://purl.obolibrary.org/obo/RO_0002500 causal agent in process Holds between c and p if and only if c is capable of some activity a, and a regulates p. http://purl.obolibrary.org/obo/RO_0002597 capable of negatively regulating http://purl.obolibrary.org/obo/RO_0002596 capable of regulating Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p. http://purl.obolibrary.org/obo/RO_0002598 capable of positively regulating http://purl.obolibrary.org/obo/RO_0002596 capable of regulating Holds between c and p if and only if c is capable of some activity a, and a positively regulates p. http://purl.obolibrary.org/obo/RO_0002608 process has causal agent http://purl.obolibrary.org/obo/RO_0002410 causally related to Inverse of 'causal agent in process' http://purl.obolibrary.org/obo/OPMI_0000438 has increased susceptibility compared to male to http://purl.obolibrary.org/obo/OPMI_0000424 has sex-specific susceptibility to An object property that represents a relation between a person with a biological sex and a process where the person has an increased susceptbility to a process compared to corresponding male population http://purl.obolibrary.org/obo/OPMI_0000439 has increased susceptibility compared to female to http://purl.obolibrary.org/obo/OPMI_0000424 has sex-specific susceptibility to An object property that represents a relation between a person with a biological sex and a process where the person has an increased susceptbility to a process compared to corresponding female population http://purl.obolibrary.org/obo/CIDO_0001195 capable of infecting host http://purl.obolibrary.org/obo/RO_0002410 causally related to An object property that represents a relation between a microbe and a host organism where the microbe is capable of infecting the host organism. http://purl.obolibrary.org/obo/RO_0002015 has positive regulatory component activity http://purl.obolibrary.org/obo/RO_0002013 has regulatory component activity A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B. http://purl.obolibrary.org/obo/RO_0002013 has regulatory component activity http://purl.obolibrary.org/obo/RO_0002017 has component activity A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B. http://purl.obolibrary.org/obo/RO_0002014 has negative regulatory component activity http://purl.obolibrary.org/obo/RO_0002013 has regulatory component activity A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B. http://purl.obolibrary.org/obo/CIDO_0000184 capable of inhibiting activity of http://purl.obolibrary.org/obo/RO_0002410 causally related to An object property between material entity a and b where a is capable of inhibiting the activity of b. http://purl.obolibrary.org/obo/CIDO_0000189 capable of priming activity of http://purl.obolibrary.org/obo/RO_0002410 causally related to An object property between material entity a and b where a is capable of priming the activity of b http://purl.obolibrary.org/obo/CIDO_0000208 catalyzed by http://purl.obolibrary.org/obo/RO_0002233 has input a subproperty of 'enabled by' that represents a relation between a process and an enzyme where a protein is catalyzed by the enzyme in a catalytic reaction http://purl.obolibrary.org/obo/RO_0009501 realized in response to http://purl.obolibrary.org/obo/RO_0002410 causally related to r 'realized in response to' s iff, r is a realizable (e.g. a plant trait such as responsivity to drought), s is an environmental stimulus (a process), and s directly causes the realization of r. http://purl.obolibrary.org/obo/RO_0016004 has exposure medium http://purl.obolibrary.org/obo/RO_0002244 related via exposure to X has exposure medium Y if X is an exposure event (process), Y is a material entity, and the stimulus for X is transmitted or carried in Y. http://purl.obolibrary.org/obo/RO_0012009 constitutively upstream of http://purl.obolibrary.org/obo/RO_0002304 causally upstream of, positive effect p is constitutively upstream of q iff p is causally upstream of q, p is required for execution of q or a part of q, and the execution of p is approximately constant. http://purl.obolibrary.org/obo/RO_0012010 removes input for http://purl.obolibrary.org/obo/RO_0002305 causally upstream of, negative effect p removes input for q iff p is causally upstream of q, there exists some c such that p has_input c and q has_input c, p reduces the levels of c, and c is rate limiting for execution of q. http://purl.obolibrary.org/obo/CIDO_0000244 variant of http://purl.obolibrary.org/obo/BFO_0000050 part_of An object property that represents a relation between a molecular variant and a gene or protein where the variant derives from the gene or protein http://purl.obolibrary.org/obo/CIDO_0000248 process capable of inducing phenotype http://purl.obolibrary.org/obo/CIDO_0000220 causal relation related to phenotype a causal relation between a process and a phenotype where the process is capable of inducing the phenotype. http://purl.obolibrary.org/obo/CIDO_0000249 agent capable of inducing phenotype http://purl.obolibrary.org/obo/CIDO_0000220 causal relation related to phenotype a causal relation between a material entity and a phenotype where the material agent is capable of inducing the phenotype. http://purl.obolibrary.org/obo/RO_0014001 disease has infectious agent http://purl.obolibrary.org/obo/RO_0004019 disease has basis in A relationship between a disease and an infectious agent where the material basis of the disease is an infection with some infectious agent. http://purl.obolibrary.org/obo/RO_0002010 regulates in other organism http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within x 'regulates in other organism' y if and only if: (x is the realization of a function to exert an effect on the frequency, rate or extent of y) AND (the agents of x are produced by organism o1 and the agents of y are produced by organism o2). http://purl.obolibrary.org/obo/RO_0002414 transitively provides input for http://purl.obolibrary.org/obo/RO_0004047 causally upstream of or within, positive effect transitive form of directly_provides_input_for http://purl.obolibrary.org/obo/RO_0002428 involved in regulation of http://purl.obolibrary.org/obo/RO_0002431 involved in or involved in regulation of c involved in regulation of p if c is involved in some p' and p' regulates some p http://purl.obolibrary.org/obo/RO_0002429 involved in positive regulation of http://purl.obolibrary.org/obo/RO_0002428 involved in regulation of c involved in regulation of p if c is involved in some p' and p' positively regulates some p http://purl.obolibrary.org/obo/RO_0002430 involved in negative regulation of http://purl.obolibrary.org/obo/RO_0002428 involved in regulation of c involved in regulation of p if c is involved in some p' and p' negatively regulates some p http://purl.obolibrary.org/obo/RO_0002508 determines http://purl.obolibrary.org/obo/RO_0002566 causally influences inverse of determined by http://purl.obolibrary.org/obo/RO_0002509 determined by part of http://purl.obolibrary.org/obo/RO_0002131 overlaps s 'determined by part of' w if and only if there exists some f such that (1) s 'determined by' f and (2) f part_of w, or f=w. http://purl.obolibrary.org/obo/RO_0002578 directly regulates http://purl.obolibrary.org/obo/RO_0002211 regulates p directly regulates q iff p is immediately causally upstream of q and p regulates q. http://purl.obolibrary.org/obo/RO_0002629 directly positively regulates http://purl.obolibrary.org/obo/RO_0002578 directly regulates p directly positively regulates q iff p is immediately causally upstream of q, and p positively regulates q. http://purl.obolibrary.org/obo/RO_0002630 directly negatively regulates http://purl.obolibrary.org/obo/RO_0002578 directly regulates p directly negatively regulates q iff p is immediately causally upstream of q, and p negatively regulates q. http://purl.obolibrary.org/obo/RO_0003002 represses expression of http://purl.obolibrary.org/obo/RO_0002449 directly negatively regulates activity of Holds between entity A (a transcription factor) and a nucleic acid B if and only if A down-regulates the expression of B. The nucleic acid can be a gene or an mRNA. http://purl.obolibrary.org/obo/RO_0003003 increases expression of http://purl.obolibrary.org/obo/RO_0002450 directly positively regulates activity of Holds between entity A (a transcription factor) and nucleic acid B if and only if A up-regulates the expression of B. The nucleic acid can be a gene or mRNA. http://purl.obolibrary.org/obo/RO_0002087 immediately preceded by http://purl.obolibrary.org/obo/BFO_0000062 preceded by starts_at_end_of http://purl.obolibrary.org/obo/RO_0002090 immediately precedes http://purl.obolibrary.org/obo/BFO_0000063 precedes meets http://purl.obolibrary.org/obo/BFO_0000071 has granular part http://purl.obolibrary.org/obo/BFO_0000051 has_part has_granular_part http://purl.obolibrary.org/obo/BFO_0000073 is granular part of http://purl.obolibrary.org/obo/BFO_0000050 part_of granular_part_of http://purl.obolibrary.org/obo/CIDO_0000386 capable of binding to http://purl.obolibrary.org/obo/CIDO_0000385 interactive relatoin between material entities http://purl.obolibrary.org/obo/CIDO_0000392 susceptible to lethal infection of http://purl.obolibrary.org/obo/CIDO_0000391 susceptible to infection of http://purl.obolibrary.org/obo/RO_0002405 immediately causally downstream of http://purl.obolibrary.org/obo/RO_0002404 causally downstream of http://purl.obolibrary.org/obo/RO_0002017 has component activity http://purl.obolibrary.org/obo/RO_0002018 has component process http://purl.obolibrary.org/obo/RO_0002559 causally influenced by http://purl.obolibrary.org/obo/RO_0002506 causal relation between entities http://purl.obolibrary.org/obo/CIDO_0000705 is characteristic AA variant of http://purl.obolibrary.org/obo/CIDO_0000600 is AA variant of http://purl.obolibrary.org/obo/BFO_0000168 has specific dependent at all times http://purl.obolibrary.org/obo/BFO_0000125 has specific dependent at some time http://purl.obolibrary.org/obo/RO_0002086 ends after http://purl.obolibrary.org/obo/RO_0002222 temporally related to http://purl.obolibrary.org/obo/CIDO_0000359 pathway susceptibly up-regulated in http://purl.obolibrary.org/obo/CIDO_0000358 pathway susceptibly regulated in http://purl.obolibrary.org/obo/CIDO_0000363 pathway susceptibly down-regulated in http://purl.obolibrary.org/obo/CIDO_0000358 pathway susceptibly regulated in http://purl.obolibrary.org/obo/CIDO_0000221 phenotype has causal agent http://purl.obolibrary.org/obo/CIDO_0000220 causal relation related to phenotype http://purl.obolibrary.org/obo/CIDO_0000224 process up-regulates agent http://purl.obolibrary.org/obo/CIDO_0000223 causal process for agent http://purl.obolibrary.org/obo/BFO_0000070 specifically depends on at all times http://purl.obolibrary.org/obo/BFO_0000169 specifically depends on at some time http://purl.obolibrary.org/obo/RO_0004033 acts upstream of or within, negative effect http://purl.obolibrary.org/obo/RO_0002264 acts upstream of or within http://purl.obolibrary.org/obo/RO_0004032 acts upstream of or within, positive effect http://purl.obolibrary.org/obo/RO_0002264 acts upstream of or within http://purl.obolibrary.org/obo/RO_0004001 has material basis in gain of function germline mutation in http://purl.obolibrary.org/obo/RO_0004000 condition has genetic basis in http://purl.obolibrary.org/obo/RO_0004002 has material basis in loss of function germline mutation in http://purl.obolibrary.org/obo/RO_0004000 condition has genetic basis in http://purl.obolibrary.org/obo/RO_0004003 has material basis in germline mutation in http://purl.obolibrary.org/obo/RO_0004000 condition has genetic basis in http://purl.obolibrary.org/obo/RO_0004004 has material basis in somatic mutation in http://purl.obolibrary.org/obo/RO_0004000 condition has genetic basis in http://purl.obolibrary.org/obo/RO_0004005 has major susceptibility factor http://purl.obolibrary.org/obo/RO_0004000 condition has genetic basis in http://purl.obolibrary.org/obo/RO_0004006 has partial material basis in germline mutation in http://purl.obolibrary.org/obo/RO_0004000 condition has genetic basis in http://purl.obolibrary.org/obo/RO_0004019 disease has basis in http://purl.obolibrary.org/obo/RO_0004023 causal relationship with disease as subject http://purl.obolibrary.org/obo/RO_0004010 is genetic basis for condition http://purl.obolibrary.org/obo/RO_0004018 is basis for realizable http://purl.obolibrary.org/obo/RO_0004025 disease causes dysfunction of http://purl.obolibrary.org/obo/RO_0004023 causal relationship with disease as subject http://purl.obolibrary.org/obo/RO_0002326 contributes to http://purl.obolibrary.org/obo/RO_0002329 part of structure that is capable of http://purl.obolibrary.org/obo/RO_0002022 directly regulated by http://purl.obolibrary.org/obo/RO_0002334 regulated by http://purl.obolibrary.org/obo/RO_0002016 has necessary component activity http://purl.obolibrary.org/obo/RO_0002017 has component activity http://purl.obolibrary.org/obo/RO_0002506 causal relation between entities http://purl.obolibrary.org/obo/RO_0002410 causally related to http://purl.obolibrary.org/obo/CIDO_0000220 causal relation related to phenotype http://purl.obolibrary.org/obo/RO_0002410 causally related to http://purl.obolibrary.org/obo/RO_0004000 condition has genetic basis in http://purl.obolibrary.org/obo/RO_0002410 causally related to http://purl.obolibrary.org/obo/RO_0004017 realizable has basis in http://purl.obolibrary.org/obo/RO_0002410 causally related to http://purl.obolibrary.org/obo/RO_0004018 is basis for realizable http://purl.obolibrary.org/obo/RO_0002410 causally related to http://purl.obolibrary.org/obo/RO_0004023 causal relationship with disease as subject http://purl.obolibrary.org/obo/RO_0040035 disease relationship http://purl.obolibrary.org/obo/CIDO_0000188 induces in vivo production of http://purl.obolibrary.org/obo/RO_0002410 causally related to http://purl.obolibrary.org/obo/RO_0004046 causally upstream of or within, negative effect http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within http://purl.obolibrary.org/obo/RO_0004047 causally upstream of or within, positive effect http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within http://purl.obolibrary.org/obo/CIDO_0000223 causal process for agent http://purl.obolibrary.org/obo/RO_0002595 causal relation between material entity and a process http://purl.obolibrary.org/obo/CIDO_0000385 interactive relatoin between material entities http://purl.obolibrary.org/obo/RO_0002609 obsolete related via dependence to http://purl.obolibrary.org/obo/CIDO_0001179 susceptibly reduces process frequency http://purl.obolibrary.org/obo/CIDO_0001178 susceptibly alters process http://purl.obolibrary.org/obo/CIDO_0001180 susceptibly increases process frequency http://purl.obolibrary.org/obo/CIDO_0001178 susceptibly alters process http://purl.obolibrary.org/obo/BFO_0000154 temporal projection of spatiotemporal http://purl.obolibrary.org/obo/BFO_0000157 during which exists http://purl.obolibrary.org/obo/BFO_0000156 has temporal occupant http://purl.obolibrary.org/obo/BFO_0000157 during which exists http://purl.obolibrary.org/obo/BFO_0000153 projects onto temporal region http://purl.obolibrary.org/obo/BFO_0000108 exists at http://purl.obolibrary.org/obo/BFO_0000155 occupies temporal region http://purl.obolibrary.org/obo/BFO_0000108 exists at http://purl.obolibrary.org/obo/RO_0002234 has output produces p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p. http://purl.obolibrary.org/obo/OBI_0000304 is_manufactured_by has_manufacturer c is_manufactured_by o means that there was a process p in which c was built in which a person, or set of people or machines did the work(bore the "Manufacturer Role", and those people/and or machines were members or of directed by the organization to do this. http://purl.obolibrary.org/obo/RO_0000053 has characteristic is bearer of Inverse of characteristic_of http://purl.obolibrary.org/obo/RO_0000056 participates in participates_in a relation between a continuant and a process, in which the continuant is somehow involved in the process http://purl.obolibrary.org/obo/RO_0000057 has_participant has_participant a relation between a process and a continuant, in which the continuant is somehow involved in the process http://purl.obolibrary.org/obo/RO_0001000 derives from derives_from a relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity http://purl.obolibrary.org/obo/RO_0001001 derives into derives_into a relation between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity http://purl.obolibrary.org/obo/RO_0001025 located in located_in a relation between two independent continuants, the target and the location, in which the target is entirely within the location http://purl.obolibrary.org/obo/CIDO_0000032 assay performed at performed at An object property that represents a relation between an assay and an organization and the assay is performed at the organization such as a company or hospital http://purl.obolibrary.org/obo/CIDO_0000118 chemical has protein target chemical has protein target as modulator An object property that represents a relation between a chemical entity and a protein where the chemical entity can target the protein. Note that the chemical entity is usually an active compound of a corresponding drug. http://purl.obolibrary.org/obo/BFO_0000066 occurs in unfolds_in b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t http://purl.obolibrary.org/obo/RO_0002233 has input consumes p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p. http://purl.obolibrary.org/obo/VO_0001243 immunizes host immunization for host A shortcut relation that equals to: 'processed material' and (is_specified_output_of some 'vaccine preparation') and ('has function' some ('vaccine function' and ('is realized by' only ('vaccine immunization' and (realizes some ('vaccine host role' and (role_of some 'organism')))))))). The domain of this relation is a vaccine. The range of this relation is a organism. http://purl.obolibrary.org/obo/VO_0003355 immunizes against pathogen vaccine immunization against pathogen A shortcut relation that equals to: processed material and (is_specified_output_of some vaccine preparation) and (has function some (vaccine function and (is realized by only (vaccine immunization and (realizes some ('immunization target role' and (role_of some 'pathogen')))))))) The domain of this relation is a vaccine. The range of this relation is a pathogen (a bacterium, a virus, a fungus, and a parasite) Ranges: organism and 'has role' some 'pathogen role' http://purl.obolibrary.org/obo/RO_0002160 only in taxon x only in taxon y if and only if x is in taxon y, and there is no other organism z such that y!=z a and x is in taxon z. http://purl.obolibrary.org/obo/VO_0004909 immunizes against disease process A shortcut object property that represents a relation between a vaccine and a disease process where the vaccine immunizes a host against a disease process. http://purl.obolibrary.org/obo/CIDO_0000022 has active ingredient An object property that represents a relation between a drug and a chemical entity that is the active ingredient of the drug http://purl.obolibrary.org/obo/CIDO_0000030 susceptible to adverse event An object property that represents a relation between a material entity (such as a drug or chemical or vaccine) and an adverse event (AE) where the administration of the material entity is susceptible to the presence of the adverse event. http://purl.obolibrary.org/obo/IAO_0000004 has measurement value A relation between a scalar measurement data item and a number that quantifies it. http://purl.obolibrary.org/obo/IAO_0000136 is about A (currently) primitive relation that relates an information artifact to an entity. http://purl.obolibrary.org/obo/OBI_0000316 obsolete_has_role A relation between a continuant C and a role R. The reciprocal relation of role_of. http://purl.obolibrary.org/obo/OBI_0000417 achieves_planned_objective This relation obtains between a planned process and a objective specification when the criteria specified in the objective specification are met at the end of the planned process. http://purl.obolibrary.org/obo/OBI_0000833 objective_achieved_by This relation obtains between an objective specification and a planned process when the criteria specified in the objective specification are met at the end of the planned process. http://purl.obolibrary.org/obo/OBI_0001937 has specified value A relation between a value specification and a number that quantifies it. http://purl.obolibrary.org/obo/OBI_1110119 bound_to A relationship between two material entities that form a complex based on a selective, non-covalent interaction. http://purl.obolibrary.org/obo/RO_0000059 concretizes A relationship between a specifically dependent continuant and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. Multiple specifically dependent continuants can concretize the same generically dependent continuant. http://purl.obolibrary.org/obo/CIDO_0000029 PCR kit detects gene A short-cut relation that represents a direct relationship between a PCR test kit and the target gene (or gene region) that the test kit is designed to run a PCR assay for amplifying and detecting the targeted gene or gene region. http://purl.obolibrary.org/obo/CIDO_0000040 has susceptible host An object property that represents a relation between a microbe and an organism that serves as the host role and can host the survival of the microbe. http://purl.obolibrary.org/obo/CIDO_0000124 drug has protein target An object property that represents a relation between a drug and a protein where the drug can target the protein. http://purl.obolibrary.org/obo/CIDO_0000139 chemical effective against virus An object property that represents a relation between a chemical entity and a virus where the chemical has an effective role against viral infection http://purl.obolibrary.org/obo/BFO_0000117 has occurrent part b has_occurrent_part c = Def. c occurrent_part_of b. (axiom label in BFO2 Reference: [007-001]) http://purl.obolibrary.org/obo/RO_0002434 interacts with A relationship that holds between two entities in which the processes executed by the two entities are causally connected. http://purl.obolibrary.org/obo/VO_0000520 has vaccine component An object property that defines a relation between a vaccine and its component http://purl.obolibrary.org/obo/VO_0000524 has vaccine antigen An object property that specifies a vaccine antigen http://purl.obolibrary.org/obo/CIDO_0000298 organism susceptibly has up-regulated gene An object property that represents a relation between an organism and a gene where the organism is susceptible to have an up-regulation of the expression of the gene. http://purl.obolibrary.org/obo/CIDO_0000299 gene susceptibly up-regulated in organism An object property that represents a relation between a gene and an organism where the gene is susceptibly up-regulated in the organism. http://purl.obolibrary.org/obo/CIDO_0000312 homologous epitope of An object property that represents a relation between two epitopes X and Y where X is an homologous epitope of Y. http://purl.obolibrary.org/obo/CIDO_0000360 binding to receptor An object property that represents a relation between a molecule and a receptor of the molecule where the molecule binds physically to the receptor. http://purl.obolibrary.org/obo/CIDO_0000610 has average R0 A data property that represents a relation between an infectious agent (such as a viral strain) and a value that is the averge number of transmissions, i.e., the basic reproduction number (or called R0 value). http://purl.obolibrary.org/obo/RO_0000091 has disposition a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0000092 disposition of inverse of has disposition http://purl.obolibrary.org/obo/CIDO_0000358 pathway susceptibly regulated in An object property that represents a relation between a pathway (biological process) and a process in which the pathway is susceptibly to differential regulation in the process. http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to A mereological relationship or a topological relationship http://purl.obolibrary.org/obo/RO_0002328 functionally related to A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities. http://purl.obolibrary.org/obo/CIDO_0000410 has epitope cross-reactivity A relation between two chemical entities X and Y such that if a portion of X is an epitope that binds to some antigen, there is also a portion of Y that is also an epitope which will bind to the same antigen. http://purl.obolibrary.org/obo/CIDO_0000417 secreted from An object property that represents a relation between a material entity (e.g., gene or protein) that is secreted from another material entity (e.g., cell). http://purl.obolibrary.org/obo/CIDO_0000173 disease process susceptibly has phenotype An object property that represents a relation between a disease process and its susceptibility of inducing a phenotype outcome http://purl.obolibrary.org/obo/CIDO_0000174 drug effective against virus An object property that represents a relation between a drug and a virus where the drug has an effective role against viral infection http://purl.obolibrary.org/obo/OPMI_0000501 admitted from An object property that represents a relation between a patient and a site from which the patient was admitted. http://purl.obolibrary.org/obo/OPMI_0000502 discharged to An object property that represents a relation between a patient and a site to which the patient was discharged after a visit. http://purl.obolibrary.org/obo/BFO_0000132 part of occurrent [copied from inverse property 'has occurrent part'] b has_occurrent_part c = Def. c occurrent_part_of b. (axiom label in BFO2 Reference: [007-001]) http://purl.obolibrary.org/obo/BFO_0000176 part of continuant at some time [copied from inverse property 'has continuant part at some time'] b has_continuant_part c at t = Def. c continuant_part_of b at t. (axiom label in BFO2 Reference: [006-001]) http://purl.obolibrary.org/obo/BFO_0000178 has continuant part at some time b has_continuant_part c at t = Def. c continuant_part_of b at t. (axiom label in BFO2 Reference: [006-001]) http://purl.obolibrary.org/obo/RO_0002410 causally related to relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause. http://purl.obolibrary.org/obo/RO_0002609 obsolete related via dependence to A relationship that holds between two entities, where the relationship holds based on the presence or absence of statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes. http://purl.obolibrary.org/obo/VO_0005242 up-expressed as immune signature of An object property that represents a relation between a material entity and biological process http://purl.obolibrary.org/obo/OPMI_0000424 has sex-specific susceptibility to An object property that represents a relation between a person with a biological sex and a process where the person has a specific susceptbility to a process http://purl.obolibrary.org/obo/CIDO_0000176 susceptibly occurs in An object property that represents a relation between a process and a material entity (particularly an organism, anatomical entity, or cell) in which the process has a susceptible disposition to occur. http://purl.obolibrary.org/obo/RO_0002292 expresses Inverse of 'expressed in' http://purl.obolibrary.org/obo/CIDO_0001089 PCR detects gene A short-cut relation that represents a direct relationship between a PCR test and the target gene (or gene region) that the test is designed to amplify and detect the targeted gene or gene region. http://purl.obolibrary.org/obo/VO_0000547 vaccinated in route An object property that specifies a relation between a vaccine and a vaccinate route http://purl.obolibrary.org/obo/RO_0040035 disease relationship This relation groups relations between diseases and any other kind of entity. http://purl.obolibrary.org/obo/CIDO_0000012 treatment for An object property that represents a relation between a material entity (e.g., drug or respirator) and a disease process where a drug is effective in treating a host against the disease process. http://purl.obolibrary.org/obo/CIDO_0000053 caused by infection with An object property that represents the relation between a disease process and a pathogen where the disease process is caused by the infection with the pathogen. http://purl.obolibrary.org/obo/BFO_0000054 realized in realized_in http://purl.obolibrary.org/obo/BFO_0000053 is_bearer_of bearer_of http://purl.obolibrary.org/obo/CIDO_0000433 has motivation An object property that represents a relation between an entity and a motivation in which the entity has the motivation. http://purl.obolibrary.org/obo/BFO_0000126 has spatiotemporal occupant http://purl.obolibrary.org/obo/BFO_0000130 occupies spatiotemporal region http://purl.obolibrary.org/obo/BFO_0000151 projects onto spatial region at some time http://purl.obolibrary.org/obo/BFO_0000152 spatial projection of spatiotemporal at some time http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#CI_ChemClass CI_ChemClass http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#CI_MoA CI_MoA http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#CI_PE CI_PE http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#CI_with CI_with http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#Display_Name Display_Name http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#FDA_UNII FDA_UNII http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#Level Level http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#MeSH_CUI MeSH_CUI http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#MeSH_DUI MeSH_DUI http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#MeSH_Definition MeSH_Definition http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#MeSH_Name MeSH_Name http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#NUI NUI http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#RxNorm_CUI RxNorm_CUI http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#RxNorm_Name RxNorm_Name http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#Synonym Synonym http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#UMLS_CUI UMLS_CUI http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#VANDF_Record VANDF_Record http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#VUID VUID http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#has_Ingredient has_Ingredient http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#has_MoA has_MoA http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#has_PE has_PE http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#has_PK has_PK http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#may_prevent may_prevent http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#may_treat may_treat http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#site_of_metabolism site_of_metabolism http://purl.obolibrary.org/obo/CIDO_0000391 susceptible to infection of http://purl.obolibrary.org/obo/CIDO_0000393 has genetic mutation http://purl.obolibrary.org/obo/BFO_0000055 realizes http://purl.obolibrary.org/obo/IAO_0000219 denotes http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#SNOMED_CID SNOMED_CID http://purl.obolibrary.org/obo/CIDO_0000024 EUA-authorized use at http://purl.obolibrary.org/obo/RO_0016001 has phenotype or disease http://purl.obolibrary.org/obo/chebi#has_functional_parent has functional parent http://purl.obolibrary.org/obo/chebi#has_parent_hydride has parent hydride http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of is conjugate acid of http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of is conjugate base of http://purl.obolibrary.org/obo/chebi#is_enantiomer_of is enantiomer of http://purl.obolibrary.org/obo/chebi#is_substituent_group_from is substituent group from http://purl.obolibrary.org/obo/chebi#is_tautomer_of is tautomer of http://purl.obolibrary.org/obo/BFO_0000083 occupies spatial region at some time http://purl.obolibrary.org/obo/BFO_0000123 has spatial occupant at some time http://purl.obolibrary.org/obo/CIDO_0000600 is AA variant of http://purl.obolibrary.org/obo/CIDO_0000604 has relative risk with no vaccination http://purl.obolibrary.org/obo/CIDO_0000605 has relative risk post-vaccination http://purl.obolibrary.org/obo/CIDO_0000606 has relative risk post-boost-vaccination http://purl.obolibrary.org/obo/CIDO_0000608 has AA mutation http://purl.obolibrary.org/obo/CIDO_0000609 is AA mutation of http://purl.obolibrary.org/obo/CIDO_0000613 has amino acid position http://purl.obolibrary.org/obo/CIDO_0000707 has mutated from http://purl.obolibrary.org/obo/RO_0002496 existence starts during or after http://purl.obolibrary.org/obo/RO_0002497 existence ends during or before http://purl.obolibrary.org/obo/BFO_0000125 has specific dependent at some time http://purl.obolibrary.org/obo/RO_0002222 temporally related to http://purl.obolibrary.org/obo/RO_0002502 depends on http://purl.obolibrary.org/obo/CIDO_0000222 disease susceptibly severe with comorbidity http://purl.obolibrary.org/obo/OPMI_0000481 has identifier http://purl.obolibrary.org/obo/BFO_0000169 specifically depends on at some time http://www.obofoundry.org/ro/ro.owl#has_proper_part has_proper_part http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#Status Status http://purl.obolibrary.org/obo/CIDO_0001177 susceptibly reduces vaccine efficacy http://purl.obolibrary.org/obo/CIDO_0001178 susceptibly alters process http://purl.obolibrary.org/obo/CIDO_0000603 has AA variant http://purl.obolibrary.org/obo/BFO_0000058 concretized by at some time http://purl.obolibrary.org/obo/BFO_0000059 concretizes at some time http://purl.obolibrary.org/obo/BFO_0000157 during which exists http://purl.obolibrary.org/obo/BFO_0000108 exists at http://purl.obolibrary.org/obo/CIDO_0001082 device utilizes material http://purl.obolibrary.org/obo/CIDO_0000010 is host of