Term IRI Term label Parent term IRI Parent term label Alternative term Definition http://purl.obolibrary.org/obo/OAE_0000023 postnasal drip AE http://purl.obolibrary.org/obo/OAE_0000378 respiratory system AE Upper Airway Cough Syndrome a respiratory system AE which has an outcome of postnasal drip, which occurs when excessive mucus is produced by the nasal Mucosa. The excess mucus accumulates in the throat or back of the nose. http://purl.obolibrary.org/obo/OAE_0000027 musculoskeletal or connective tissue AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event musculoskeletal and connective tissue disorder AE an adverse event that has an outcome of abnormal sign in a musculoskeletal or connective tissue. http://purl.obolibrary.org/obo/OAE_0000034 fatigue AE http://purl.obolibrary.org/obo/OAE_0000580 behavioral and neurological AE lethargy AE a behavior and neurological AE that has an outcome of fatigue, which is a state of awareness describing a range of afflictions, usually associated with physical and/or mental weakness, though varying from a general state of lethargy to a specific work-induced burning sensation within one's muscles. Physical fatigue is the inability to continue functioning at the level of one's normal abilities. http://purl.obolibrary.org/obo/OAE_0000040 procedural complication AE http://purl.obolibrary.org/obo/OAE_0002626 injury or procedural complication AE procedure AE an adverse event that shows a complication that occurs after a medical procedure and is directly related to the precedure itself. http://purl.obolibrary.org/obo/OAE_0000050 hot flushes AE http://purl.obolibrary.org/obo/OAE_0000543 skin AE hot flush AE a skin adverse event that is characterized by an uncomfortable and temporary sensation of intense body warmth, flushing, sometimes accompanied by sweating upon cooling. http://purl.obolibrary.org/obo/OAE_0000052 tumor AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event tumour AE an adverse event that results in the outcome of a tumor. http://purl.obolibrary.org/obo/OAE_0000063 systematic AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event systematic adverse event an adverse event that occurs systematically throughout the systemic circulation. This is different from local adverse event that is limited or a certain location. http://purl.obolibrary.org/obo/OAE_0000064 pregnancy AE http://purl.obolibrary.org/obo/OAE_0000219 prenatal, perinatal or neonatal disorder AE prenatal AE A pregnancy, neonatal and perinatal AE that displays a disorder associated with pregnancy. http://purl.obolibrary.org/obo/OAE_0000066 surgery AE http://purl.obolibrary.org/obo/OAE_0000040 procedural complication AE surgical procedure AE a procedure complication AE that occurs after a surgery. http://purl.obolibrary.org/obo/OAE_0000067 surgery http://purl.obolibrary.org/obo/OAE_0002807 medical procedure surgical procedure Surgery is a medical procedure that uses operative manual and instrumental techniques on a patient to investigate and/or treat a pathological condition such as disease or injury, to help improve bodily function or appearance. The key difference between a surgery and a general procedure is the need for an incision. Making an incision, or cutting into the skin to gain access to the body’s deeper tissues or organs, is a defining characteristic of surgery. http://purl.obolibrary.org/obo/OAE_0000069 metabolism, endocrine or exocrine system AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event metabolism, endocrine, and exocrine system AE an adverse event which occurs in a metabolism process (including anabolism and catabolism), endocrine system, or exocrine system. http://purl.obolibrary.org/obo/OAE_0000162 sensory neuropathy AE http://purl.obolibrary.org/obo/OAE_0000418 neuropathy AE sensory neuropathy AE a peripheral neuropathy AE which has an outcome of sensory neuropathy that involves damage to nerves of the peripheral nervous system. http://purl.obolibrary.org/obo/OAE_0000171 distal neuropathy AE http://purl.obolibrary.org/obo/OAE_0000337 peripheral neuropathy AE axonal neuropathy AE a peripheral neuropathy AE which affects extremities, such as, toes, fingers, hand and feet. http://purl.obolibrary.org/obo/OAE_0000198 ischemia AE http://purl.obolibrary.org/obo/OAE_0000493 cardiovascular AE ischaemia AE A cardiovascular disorder AE that results in Insufficient blood supply for the need of a part of the body, usually as a result of a disease of the blood vessels supplying that part. http://purl.obolibrary.org/obo/OAE_0000199 hair, skin or nail AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event hair, skin, and nail AE an adverse event that occurs in hair, skin, or nail. http://purl.obolibrary.org/obo/OAE_0000219 prenatal, perinatal or neonatal disorder AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event pregnancy, neonatal and perinatal disorder AE an adverse event that displays a disorder associated with child birth, newborn infant, or an infant. http://purl.obolibrary.org/obo/OAE_0000226 medical intervention site AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event application site reaction an adverse event that occurs in the site of a medical intervention (e.g., vaccination injection site). http://purl.obolibrary.org/obo/OAE_0000236 arterial disorder AE http://purl.obolibrary.org/obo/OAE_0000085 vascular disorder AE arterial disease AE a vascular disorder AE that affects the artery http://purl.obolibrary.org/obo/OAE_0000301 atrial flutter AE http://purl.obolibrary.org/obo/OAE_0000660 arrhythmia AE auricular flutter an arrhythmia AE that is characterized by rapid regular atrial contractions occurring usually at rates between 250 and 400 per minute and often producing saw-tooth waves in an electrocardiogram. http://purl.obolibrary.org/obo/OAE_0000310 dyspnea AE http://purl.obolibrary.org/obo/OAE_0000571 abnormal respiration AE dyspnoea AE dyspnoea AE is an abnormal respiration AE debilitating symptom that is the experience of unpleasant or uncomfortable respiratory sensations, shortness of breath, air hunger http://purl.obolibrary.org/obo/OAE_0000316 conduction system disorder AE http://purl.obolibrary.org/obo/OAE_0000084 cardiac disorder AE conduction disorder AE a cardiac disorder AE of the electrical conduction system that controls the heart rate, generates and conducts electrical impulses throughout the muscle of the heart, stimulating the heart to contract and pump blood. http://purl.obolibrary.org/obo/OAE_0000328 kidney AE http://purl.obolibrary.org/obo/OAE_0000622 urinary system AE abnormal renal function AE an adverse event that occurs in kidney. http://purl.obolibrary.org/obo/OAE_0000337 peripheral neuropathy AE http://purl.obolibrary.org/obo/OAE_0000418 neuropathy AE neuropathy peripheral AE an neuropathy AE that results in a damage to the peripheral nervous system (PNS, outside the brain and spinal cord), the vast communication network that transmits information from the brain and the spinal cord (the central nervous system) to every other part of the body. http://purl.obolibrary.org/obo/OAE_0000350 rhinitis AE http://purl.obolibrary.org/obo/OAE_0000564 respiratory system inflammation AE runny nose rhinitis AE is a respiratory system inflammation characterized by runny nose,irritation and inflammation of some internal areas of the nose http://purl.obolibrary.org/obo/OAE_0000354 sneezing AE http://purl.obolibrary.org/obo/OAE_0000378 respiratory system AE sternutation sneezing AE is a respiratory system adverse event that results in sternutation, a semi-autonomous, convulsive expulsion of air from the lungs through the nose and mouth, usually caused by foreign particles irritating the nasal mucosa http://purl.obolibrary.org/obo/OAE_0000358 upper respiratory tract infection AE http://purl.obolibrary.org/obo/OAE_0000363 infection AE URI, URTI an infection AE is a respiratory system AE that results in illnesses caused by an acute infection which involves the upper respiratory tract: nose, sinuses, pharynx or larynx http://purl.obolibrary.org/obo/OAE_0000361 fever AE http://purl.obolibrary.org/obo/OAE_0000624 abnormal body temperature AE pyrexia AE an abnormal body temperature AE which has an outcome of fever http://purl.obolibrary.org/obo/OAE_0000363 infection AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event infectious adverse event an adverse event that has an outcome of a pathogen infection, i.e., an infection caused by a pathogen such as a virus, bacterium, or parasite. http://purl.obolibrary.org/obo/OAE_0000366 injection-site AE http://purl.obolibrary.org/obo/OAE_0002625 local AE local reaction AE injection-site AE is an AE that occurs in an injection site (e.g., during vaccination). http://purl.obolibrary.org/obo/OAE_0000373 pruritus AE http://purl.obolibrary.org/obo/OAE_0000543 skin AE pruritus generalised AE a skin adverse event that has an outcome of pruritus http://purl.obolibrary.org/obo/OAE_0000375 myalgia AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE muscle pain AE a pain AE that has outcome of myalgia. Myalgia means "muscle pain" and is a symptom of many diseases and disorders. http://purl.obolibrary.org/obo/OAE_0000376 urticaria AE http://purl.obolibrary.org/obo/OAE_0000362 rash AE hives Urticaria AE is a rash AE notable for dark red, raised, itchy bumps. http://purl.obolibrary.org/obo/OAE_0000379 leukocyte cell number increased AE http://purl.obolibrary.org/obo/OAE_0001673 leukocyte cell number abnormal AE white blood cell count increased AE a leukocyte cell number abnormal AE that has an outcome of greater than normal number of leukocytes, or nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue http://purl.obolibrary.org/obo/OAE_0000380 leukocyte cell number decreased AE http://purl.obolibrary.org/obo/OAE_0001673 leukocyte cell number abnormal AE white blood cell count decreased AE a leukocyte cell number abnormal AE that has an outcome of reduction in the number of leukocytes, or of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue http://purl.obolibrary.org/obo/OAE_0000384 maculo-papular rash AE http://purl.obolibrary.org/obo/OAE_0000362 rash AE rash maculopapular AE A rash AE that shows a flat, red area on the skin overed with small confluent bumps. http://purl.obolibrary.org/obo/OAE_0000389 edema limbs AE http://purl.obolibrary.org/obo/OAE_0000556 edema AE peripheral edema AE peripheral edema AE is an edema AE that results in swelling of tissues, usually in the lower limbs, due to the accumulation of fluids http://purl.obolibrary.org/obo/OAE_0000391 somnolence AE http://purl.obolibrary.org/obo/OAE_0000580 behavioral and neurological AE drowsiness a behavior and neurological AE that has an outcome of somnolence http://purl.obolibrary.org/obo/OAE_0000392 paresthesia AE http://purl.obolibrary.org/obo/OAE_0000162 sensory neuropathy AE paraesthesia AE a sensory neuropathy AE that shows a sensation of tingling, pricking, or numbness of a person's skin with no apparent long-term physical effect. http://purl.obolibrary.org/obo/OAE_0000394 chills AE http://purl.obolibrary.org/obo/OAE_0000582 sensory capability AE feeling cold AE a sensory capability AE that has an outcome of chills http://purl.obolibrary.org/obo/OAE_0000396 anorexia AE http://purl.obolibrary.org/obo/OAE_0000574 gustatory system AE decreased appetite AE a gustatory system AE which demonstrates a decreased sensation of appetite. http://purl.obolibrary.org/obo/OAE_0000397 face edema AE http://purl.obolibrary.org/obo/OAE_0000556 edema AE oedema face AE face edema AE is an edema AE that results in facial swelling, the build-up of fluid in the tissues of the face. Swelling may also affect the neck and upper arms http://purl.obolibrary.org/obo/OAE_0000398 cough AE http://purl.obolibrary.org/obo/OAE_0000571 abnormal respiration AE coughing AE an abnormal respiration AE that shows a sudden and often repetitively occurring reflex to keep the throat and airways clear http://purl.obolibrary.org/obo/OAE_0000399 flu syndrome AE http://purl.obolibrary.org/obo/OAE_0000490 acute brain syndrome AE flu-like symptom AE a syndrome AE that has an outcome of a flu syndrome AE and occurs after a medical intervention. http://purl.obolibrary.org/obo/OAE_0000400 syncope AE http://purl.obolibrary.org/obo/OAE_0000582 sensory capability AE Syncope is the medical term for fainting, a sudden, usually temporary, loss of consciousness. a sensory capability AE that has an outcome of loss of consciousness, fainting http://purl.obolibrary.org/obo/OAE_0000403 hypertension AE http://purl.obolibrary.org/obo/OAE_0000381 abnormal blood pressure AE blood pressure increased an abnormal blood pressure AE that has an outcome of sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states http://purl.obolibrary.org/obo/OAE_0000416 gastrointestinal hemorrhage AE http://purl.obolibrary.org/obo/OAE_0000427 hemorrhage AE gastrointestinal haemorrhage AE a hemorrhage AE that has an outcome of gastrointestinal hemorrhage http://purl.obolibrary.org/obo/OAE_0000423 skin discoloration AE http://purl.obolibrary.org/obo/OAE_0000543 skin AE skin discolouration AE skin discoloration AE is a skin adverse event that results in change in color of skin or mucus membranes http://purl.obolibrary.org/obo/OAE_0000427 hemorrhage AE http://purl.obolibrary.org/obo/OAE_0000493 cardiovascular AE haemorrhage AE a cardiovascular disorder AE that has an outcome of hemorrhage http://purl.obolibrary.org/obo/OAE_0000434 lung AE http://purl.obolibrary.org/obo/OAE_0000378 respiratory system AE lung disorder AE a respiratory system AE which has an outcome of lung disorder http://purl.obolibrary.org/obo/OAE_0000436 hepatobiliary or pancreatic AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event liver, biliary, and pancreatic disorder AE an adverse event that occurs in liver, biliary, and pancreatic areas. http://purl.obolibrary.org/obo/OAE_0000441 confusion AE http://purl.obolibrary.org/obo/OAE_0001797 psychiatric disorder AE mental confusion AE a psychiatric disorder AE that has an outcome of confusion, which is a mild form of delirium. http://purl.obolibrary.org/obo/OAE_0000443 eye AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event eye disorder AE an AE that occurs in eye. http://purl.obolibrary.org/obo/OAE_0000461 cardiac arrest http://purl.obolibrary.org/obo/OAE_0000084 cardiac disorder AE heart arrest AE a cardiac disorder AE that has an outcome of heartarrest, the abrupt cessation of normal circulation of the blood due to failure of the heart to contract effectively during systole. http://purl.obolibrary.org/obo/OAE_0000465 ear AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event ear disorder AE an AE that occurs in ear. http://purl.obolibrary.org/obo/OAE_0000476 immune system AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event immune system disorder AE an AE that occurs in immune system. http://purl.obolibrary.org/obo/OAE_0000493 cardiovascular AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event cardiovascular disorder AE an AE that occurs in cardiovascular system. http://purl.obolibrary.org/obo/OAE_0000505 dry mouth AE http://purl.obolibrary.org/obo/OAE_0000439 digestive system AE xerostomia a digestive system AE which has an outcome of dry mouth, which is dryness of the mouth resulting from reduced salivary secretion http://purl.obolibrary.org/obo/OAE_0000508 epistaxis AE http://purl.obolibrary.org/obo/OAE_0000427 hemorrhage AE nosebleed a hemorrhage AE that has an outcome of epistaxis http://purl.obolibrary.org/obo/OAE_0000512 hallucination AE http://purl.obolibrary.org/obo/OAE_0001797 psychiatric disorder AE hallucinations AE a psychiatric disorder AE that has an outcome of hallucination http://purl.obolibrary.org/obo/OAE_0000518 bone AE http://purl.obolibrary.org/obo/OAE_0000027 musculoskeletal or connective tissue AE bone disorder a musculoskeletal system AE that occurs in the bone http://purl.obolibrary.org/obo/OAE_0000528 pustular rash AE http://purl.obolibrary.org/obo/OAE_0000362 rash AE rash pustular AE a rash AE that is characterized by a circumscribed and elevated skin lesion filled with pus. http://purl.obolibrary.org/obo/OAE_0000541 weight loss AE http://purl.obolibrary.org/obo/OAE_0001644 physical examination result abnormal AE weight decreased AE a physical examination result abnormal AE that has an outcome of weight loss, which is the progressive reduction of body weight below normal average for age http://purl.obolibrary.org/obo/OAE_0000544 abnormal gait AE http://purl.obolibrary.org/obo/OAE_0000581 movement disorder AE gait disturbance AE a movement disorder AE that has an outcome of unusual or distinctive way of walking http://purl.obolibrary.org/obo/OAE_0000545 dehydration AE http://purl.obolibrary.org/obo/OAE_0000546 abnormal fluid regulation AE hypohydration an abnormal fluid regulation AE which has an outcome of dehydration, which is an excessive water loss from the body or from an organ or bodily part http://purl.obolibrary.org/obo/OAE_0000550 anemia AE http://purl.obolibrary.org/obo/OAE_0000588 hematopoietic system AE anaemia AE a hematopoietic system AE which has an outcome of anemia, which is less than normal levels of red blood cells and/or hemoglobin within red blood cells, or volume of packed red blood cells in the bloodstream, resulting in insufficient oxygenation of tissues and organs http://purl.obolibrary.org/obo/OAE_0000551 hypotension AE http://purl.obolibrary.org/obo/OAE_0000381 abnormal blood pressure AE blood pressure decreased, low blood pressure an abnormal blood pressure AE that has an outcome of sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states http://purl.obolibrary.org/obo/OAE_0000556 edema AE http://purl.obolibrary.org/obo/OAE_0000546 abnormal fluid regulation AE oedema, swelling, dropsy an abnormal fluid regulation AE which has an outcome of edema, which is an accumulation of an excessive amount of watery fluid in cells or intercellular tissues http://purl.obolibrary.org/obo/OAE_0000567 sinusitis AE http://purl.obolibrary.org/obo/OAE_0000564 respiratory system inflammation AE sinus inflammation AE a respiratory system inflammation AE which has an outcome of sinus inflammation, an inflammation of paranasal sinuses, which may be due to infection, allergy, or autoimmune issues. http://purl.obolibrary.org/obo/OAE_0000568 allergy AE http://purl.obolibrary.org/obo/OAE_0000584 hypersensitivity AE anaphylactic reaction AE a hypersensitivity AE which results in an allergic response showing a marked increase in reactivity to an antigen upon subsequent exposure. http://purl.obolibrary.org/obo/OAE_0000570 nervous system AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event nervous system disorder AE an AE that occurs in nervous system. http://purl.obolibrary.org/obo/OAE_0000572 apnea AE http://purl.obolibrary.org/obo/OAE_0000571 abnormal respiration AE MedDRA: 10002974 is for "apnoea"; MedDRA: 10002972 is for "apnea". an abnormal respiration AE which has an outcome of apnea, temporary cessation of breathing; sometimes episodic http://purl.obolibrary.org/obo/OAE_0000580 behavioral and neurological AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event disruptive behavioral disorder AE an adverse event that has an outcome of an abnormal behavior and neurological phenotype. http://purl.obolibrary.org/obo/OAE_0000584 hypersensitivity AE http://purl.obolibrary.org/obo/OAE_0000476 immune system AE hypersensitivity reaction AE Hypersensitivity AE is a immune system AE that is a set of undesirable reactions produced by the normal immune system, including allergies and autoimmunity. These reactions may be damaging, uncomfortable, or occasionally fatal. http://purl.obolibrary.org/obo/OAE_0000590 increased heart rate AE http://purl.obolibrary.org/obo/OAE_0000660 arrhythmia AE tachycardia an arrhythmia AE that has an outcome of greater than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute http://purl.obolibrary.org/obo/OAE_0000599 platelet count decreased AE http://purl.obolibrary.org/obo/OAE_0001731 platelet count abnormal AE decreased platelet cell number AE a hematopoietic system AE which has an outcome of decreased platelet count, which is fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation http://purl.obolibrary.org/obo/OAE_0000602 constipation AE http://purl.obolibrary.org/obo/OAE_0000603 abnormal defecation AE infrequent bowel movements AE an abnormal defecation AE that has an outcome of constipation, which is incomplete, infrequent or difficult evacuation of fecal matter http://purl.obolibrary.org/obo/OAE_0000604 urinary incontinence AE http://purl.obolibrary.org/obo/OAE_0000622 urinary system AE MedDRA: 10046543 a urinary system AE that has an outcome of the symptom of urinary incontinence, which is the inability to control the urinary excretory functions. http://purl.obolibrary.org/obo/OAE_0000615 lymphocyte count increased AE http://purl.obolibrary.org/obo/OAE_0001676 lymphocyte count abnormal AE lymphocyte cell number increased AE a lymphocyte count abnormal AE that has an outcome of greater than normal number of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells http://purl.obolibrary.org/obo/OAE_0000616 diarrhea AE http://purl.obolibrary.org/obo/OAE_0000603 abnormal defecation AE diarrhoea AE an abnormal defecation AE that has an outcome of diarrhea, which is abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel http://purl.obolibrary.org/obo/OAE_0000619 hematuria AE http://purl.obolibrary.org/obo/OAE_0000622 urinary system AE haematuria AE a urinary system AE that results in the presence of blood in the urine http://purl.obolibrary.org/obo/OAE_0000621 decreased heart rate AE http://purl.obolibrary.org/obo/OAE_0000660 arrhythmia AE heart rate decreased AE an arrhythmia AE that has an outcome of fewer than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute http://purl.obolibrary.org/obo/OAE_0000623 hypothermia AE http://purl.obolibrary.org/obo/OAE_0000624 abnormal body temperature AE decreased body temperature AE an abnormal body temperature AE which has an outcome of decreased body temperature, which is less than the level of heat natural to a living being http://purl.obolibrary.org/obo/OAE_0000628 investigation result abnormal AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event laboratory test abnormal an adverse event that is indicated by an abnormal result of an investigation that uses some laboratory equipment, device, or medical technology. http://purl.obolibrary.org/obo/OAE_0000650 hematoma AE http://purl.obolibrary.org/obo/OAE_0000493 cardiovascular AE haematoma AE an cardiovascular adverse event that is a collection of blood outside the blood vessels, generally the result of hemorrhage, or more specifically, internal bleeding. It is commonly called a bruise. http://purl.obolibrary.org/obo/OAE_0000659 atrial fibrillation AE http://purl.obolibrary.org/obo/OAE_0000660 arrhythmia AE AF an arrhythmia AE that involves the two upper chambers (atria) of the heart http://purl.obolibrary.org/obo/OAE_0000660 arrhythmia AE http://purl.obolibrary.org/obo/OAE_0000084 cardiac disorder AE cardiac arrhythmia AE a cardiac disorder AE which has an outcome of abnormal heart rhythm http://purl.obolibrary.org/obo/OAE_0000681 periorbital edema AE http://purl.obolibrary.org/obo/OAE_0000556 edema AE periorbital puffiness periorbial edema AE is an edema AE that has an outcome of swelling around the eye. http://purl.obolibrary.org/obo/OAE_0000691 skin ulceration AE http://purl.obolibrary.org/obo/OAE_0000543 skin AE skin ulcer AE a skin AE that shows a result of skin ulcer, i.e., a sore on the skin or a mucous membrane, accompanied by the disintegration of tissue. Ulcers can result in complete loss of the epidermis and often portions of the dermis and even subcutaneous fat. http://purl.obolibrary.org/obo/OAE_0000697 vaginal hemorrhage AE http://purl.obolibrary.org/obo/OAE_0000082 female reproductive system AE vaginal haemorrhage AE a hemorrhage AE that has an outcome of vaginal hemorrhage http://purl.obolibrary.org/obo/OAE_0000722 blood amylase level increased AE http://purl.obolibrary.org/obo/OAE_0001689 blood amylase level abnormal AE serum amylase increased AE a blood amylase level abnormal AE that has an outcome of an increased amount of amylase, an enzyme that helps digest carbohydrates; may indicate disease or inflammation of the pancreas http://purl.obolibrary.org/obo/OAE_0000729 blood creatinine level increased AE http://purl.obolibrary.org/obo/OAE_0001588 blood creatinine level abnormal AE serum creatinine increased a blood creatinine level abnormal AE that has an outcome of an increased level of creatinine in the blood (due to lack of kidney activity) http://purl.obolibrary.org/obo/OAE_0000752 bone marrow depression AE http://purl.obolibrary.org/obo/OAE_0000753 bone marrow disorder AE hypocellular bone marrow a bone marrow disorder AE that has an outcome of an abnormal condition in which the bone marrow is unable to produce normal amounts of red blood cells, white blood cells and platelets http://purl.obolibrary.org/obo/OAE_0000761 brain edema AE http://purl.obolibrary.org/obo/OAE_0000556 edema AE brain oedema AE an edema AE that has an outcome of edema or swelling of the extravascular compartment from uptake of water in the gray and white matter http://purl.obolibrary.org/obo/OAE_0000773 cecitis AE http://purl.obolibrary.org/obo/OAE_0000439 digestive system AE typhlitis AE a digestive system AE that has an outcome of inflammation of the caecum, part of the large intestine http://purl.obolibrary.org/obo/OAE_0000775 capillary leak syndrome AE http://purl.obolibrary.org/obo/OAE_0000493 cardiovascular AE Clarkson's Disease AE a cardiovascular disorder AE that has an outcome of self-reversing episodes during which the endothelial cells which line the capillaries are thought to separate for a few days, allowing for a leakage of fluid from the circulatory system to the interstitial space, resulting in hypotension, hemoconcentration, and hypoalbuminemia http://purl.obolibrary.org/obo/OAE_0000779 cardiac failure AE http://purl.obolibrary.org/obo/OAE_0000084 cardiac disorder AE heart failure a cardiovascular disorder AE that results in the inability of the heart to provide sufficient pump action to distribute blood flow to meet the needs of the body http://purl.obolibrary.org/obo/OAE_0000895 duodenal ulcer AE http://purl.obolibrary.org/obo/OAE_0004230 duodenum AE peptic ulcer AE a duodenum AE that has an outcome of a peptic ulcer, or a defect in the lining of the stomach or the first part of the small intestine, located in the duodenum http://purl.obolibrary.org/obo/OAE_0000921 erectile dysfunction AE http://purl.obolibrary.org/obo/OAE_0000083 male reproductive system AE impotence AE a male reproductive system AE that results in the inability to develop/maintain an erection of penis http://purl.obolibrary.org/obo/OAE_0000943 febrile neutropenia AE http://purl.obolibrary.org/obo/OAE_0001217 neutropenia AE neutropenic sepsis AE a neutropenia AE, generally a complication of chemotherapy, that has an outcome of an abnormally low neutrophil granulocyte count, accompanied by fever http://purl.obolibrary.org/obo/OAE_0000964 gamma-glutamyltransferase level increased AE http://purl.obolibrary.org/obo/OAE_0000963 gamma-glutamyltransferase level abnormal AE GGT increased a gamma-glutamyltransferase level abnormal AE that has an outcome of an increase in gamma-glutamyltransferase enzyme presence in the liver http://purl.obolibrary.org/obo/OAE_0000967 gastric ulcer AE http://purl.obolibrary.org/obo/OAE_0001845 gastric disorder AE 胃溃疡 a gastric disorder AE that has an outcome of a defect in the lining of the stomach http://purl.obolibrary.org/obo/OAE_0000974 gastroesophageal reflux disease AE http://purl.obolibrary.org/obo/OAE_0000439 digestive system AE gastrooesophageal reflux disease AE a digestive system AE that results in mucosal damage caused by acid from stomach coming up to the esophagus http://purl.obolibrary.org/obo/OAE_0001009 hemoglobin level abnormal AE http://purl.obolibrary.org/obo/OAE_0001665 red blood cell profile abnormal AE haemoglobin abnormal AE a red blood cell profile abnormal AE that has an outcome of an abnormal count of hemoglobin, or iron-containing oxygen-transport metalloprotein in red blood cells http://purl.obolibrary.org/obo/OAE_0001012 hemolytic uremic syndrome AE http://purl.obolibrary.org/obo/OAE_0000364 syndrome AE haemolytic uraemic syndrome AE a hematopoietic system AE that has an outcome of hemolytic anemia, acute kidney failure and a low platelet count http://purl.obolibrary.org/obo/OAE_0001018 hemorrhoidal hemorrhage AE http://purl.obolibrary.org/obo/OAE_0000439 digestive system AE haemorrhoidal haemorrhage AE a digestive system AE that has an outcome of bleeding in hemorrhoids, vascular structures in the anal canal which help with stool control http://purl.obolibrary.org/obo/OAE_0001019 hemorrhoids AE http://purl.obolibrary.org/obo/OAE_0000439 digestive system AE haemorrhoids AE a digestive system AE that has an outcome of painful, swollen veins in the lower portion of the rectum or anus http://purl.obolibrary.org/obo/OAE_0001044 hypercalcemia AE http://purl.obolibrary.org/obo/OAE_0001585 blood calcium abnormal AE hypercalcaemia AE a blood calcium abnormal AE that has an outcome of an elevated calcium level in the blood, above normal range of 9-10.5 mg/dL http://purl.obolibrary.org/obo/OAE_0001046 hyperkalemia AE http://purl.obolibrary.org/obo/OAE_0001577 blood potassium abnormal AE hyperkalaemia AE a blood potassium abnormal AE that has a lab test outcome of an abnormally increased concentration of potassium in blood http://purl.obolibrary.org/obo/OAE_0001052 hypertriglyceridemia AE http://purl.obolibrary.org/obo/OAE_0000588 hematopoietic system AE hypertriglyceridaemia AE a hematopoietic system AE that has an outcome of high blood levels of triglycerides, abundant fatty molecules http://purl.obolibrary.org/obo/OAE_0001053 hyperuricemia AE http://purl.obolibrary.org/obo/OAE_0000596 arthritis AE hyperuricaemia AE an arthritis AE that has an outcome of uric acid building up in blood and causes joint inflammation http://purl.obolibrary.org/obo/OAE_0001054 hypoalbuminemia AE http://purl.obolibrary.org/obo/OAE_0002594 blood albumin abnormal AE hypoalbuminaemia AE a blood albumin abnormal AE that shows an abnormally low level of albumin protein in the blood. http://purl.obolibrary.org/obo/OAE_0001055 hypocalcemia AE http://purl.obolibrary.org/obo/OAE_0001585 blood calcium abnormal AE hypocalcaemia AE a blood calcium abnormal AE that has an outcome of abnormally low calcium levels, can present with convulsions, arrythmias, tetany and numbness http://purl.obolibrary.org/obo/OAE_0001057 hypoglycemia AE http://purl.obolibrary.org/obo/OAE_0000583 glucose homeostasis AE hypoglycaemia AE a glucose homeostasis AE that results in a abnormally diminished content of glucose in the blood http://purl.obolibrary.org/obo/OAE_0001059 hypomagnesemia AE http://purl.obolibrary.org/obo/OAE_0001581 blood magnesium abnormal AE hypomagnesaemia AE a blood magnesium abnormal AE that has an outcome of an abnormal concentration of magnesium in the blood plasma, and may cause nausea, weakness and tremors. http://purl.obolibrary.org/obo/OAE_0001062 hypophosphatemia AE http://purl.obolibrary.org/obo/OAE_0002593 blood phosphate abnormal AE hypophosphataemia AE a hematopoietic system AE that has an outcome of abnormally low phosphate levels, can present with muscle dysfunction, white cell dysfunction, pulp chambers and mental status changes http://purl.obolibrary.org/obo/OAE_0001068 ileus AE http://purl.obolibrary.org/obo/OAE_0000439 digestive system AE intestinal obstruction AE a digestive system AE that has an outcome of a partially or completely blocked bowel http://purl.obolibrary.org/obo/OAE_0001105 irritability AE http://purl.obolibrary.org/obo/OAE_0000580 behavioral and neurological AE feverish (subjective) AE Behavior and Neurological AE that results in the patient being easily annoyed/irritated http://purl.obolibrary.org/obo/OAE_0001133 lipase increased AE http://purl.obolibrary.org/obo/OAE_0000439 digestive system AE hyperlipasemia AE a digestive system AE that has an outcome of an excess of lipase, a pancreatic enzyme, may indicate a problem related to pancreas http://purl.obolibrary.org/obo/OAE_0001135 liver AE http://purl.obolibrary.org/obo/OAE_0000436 hepatobiliary or pancreatic AE liver disorder Liver/biliary system AE that results in the disease of the liver http://purl.obolibrary.org/obo/OAE_0001139 localized edema AE http://purl.obolibrary.org/obo/OAE_0000556 edema AE localised oedema AE an edema AE occuring in a specific region http://purl.obolibrary.org/obo/OAE_0001161 coronary artery disorder AE http://purl.obolibrary.org/obo/OAE_0000236 arterial disorder AE coronary artery disese AE an arterial disorder AE that resuts in arteries that supply blood to heart muscle become hardened and narrowed. http://purl.obolibrary.org/obo/OAE_0001222 neutrophil count decreased AE http://purl.obolibrary.org/obo/OAE_0001221 neutrophil count abnormal AE neutropenia AE a neutrophil count abnormal AE that has an outcome of decreased neutrophil count http://purl.obolibrary.org/obo/OAE_0001232 esophageal pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE oesophageal pain AE a pain AE located in the esophagus http://purl.obolibrary.org/obo/OAE_0001233 esophageal stenosis AE http://purl.obolibrary.org/obo/OAE_0004228 esophagus AE oesophageal stenosis AE an esophagus AE that results in a narrowing in the esophagus caused by buildup of scar tissue or by a congenital defect http://purl.obolibrary.org/obo/OAE_0001234 esophagitis AE http://purl.obolibrary.org/obo/OAE_0004228 esophagus AE oesophagitis AE an esophagus AE located in the esophagus, can present with heartburn, and nausea http://purl.obolibrary.org/obo/OAE_0001271 palmar-plantar erythrodysesthesia syndrome AE http://purl.obolibrary.org/obo/OAE_0000543 skin AE palmar-plantar erythrodysaesthesia syndrome AE a skin AE generally caused by chemotherapy that is characterized by the palms and soles becoming red, swollen, numb and the skin peeling. http://purl.obolibrary.org/obo/OAE_0001276 papilloedema AE http://purl.obolibrary.org/obo/OAE_0000556 edema AE papilledema AE an edema AE that has an outcome of optic disc swelling that is caused by increased intracranial pressure http://purl.obolibrary.org/obo/OAE_0001279 paronychia AE http://purl.obolibrary.org/obo/OAE_0001398 skin infection AE nail infection AE a skin infection AE thar occurs around the fingernails and toenailsnail. Bacteria or a type of yeast called Candida cause this infection. Bacteria and yeast can even combine into one infection. http://purl.obolibrary.org/obo/OAE_0001283 periodontal disease AE http://purl.obolibrary.org/obo/OAE_0000439 digestive system AE gingivitis AE a digestive system AE that has an outcome of inflammation and infection that destroys the tissues that support the teeth, including the gums, the periodontal ligaments and the tooth sockets http://purl.obolibrary.org/obo/OAE_0001285 peripheral ischemia AE http://purl.obolibrary.org/obo/OAE_0000198 ischemia AE peripheral ischaemia AE an ischaemia AE that has an outcome of restriction in blood supply to tissues, causing a shortage of oxygen and glucose needed for cellular metabolism http://purl.obolibrary.org/obo/OAE_0001295 photosensitivity reaction AE http://purl.obolibrary.org/obo/OAE_0000543 skin AE photosensitivity AE a skin AE that shows a cutaneous disease as a result of sun allergy and may be induced by different triggers such as a chemical. http://purl.obolibrary.org/obo/OAE_0001297 atrioventricular block AE http://purl.obolibrary.org/obo/OAE_0000316 conduction system disorder AE heart block a conduction system disorder AE that refers to partial or complete block of electrical impulses originating in the atrium or sinus node, preventing them from reaching the AV node and ventricles http://purl.obolibrary.org/obo/OAE_0001299 pleural hemorrhage AE http://purl.obolibrary.org/obo/OAE_0000427 hemorrhage AE pleural haemorrhage AE a hemorrhage AE that has an outcome of bleeding in the pleural cavity, the potential space between the two pleura of the lungs http://purl.obolibrary.org/obo/OAE_0001307 pneumonitis AE http://purl.obolibrary.org/obo/OAE_0000563 lung inflammation AE pulmonitis AE a lung inflammation AE located in the lung tissue http://purl.obolibrary.org/obo/OAE_0001312 portal vein thrombosis AE http://purl.obolibrary.org/obo/OAE_0000185 thrombosis AE PVT a thrombosis AE that has an outcome of formation of a blood clot affecting the hepatic portal vein, can lead to hypertension or reduction of blood supply to the liver http://purl.obolibrary.org/obo/OAE_0001321 prinzmetal angina AE http://purl.obolibrary.org/obo/OAE_0001161 coronary artery disorder AE coronary vessel spasm AE a coronary artery disorder AE that results in cardiac pain at rest that occurs in cycles http://purl.obolibrary.org/obo/OAE_0001345 pulmonary edema AE http://purl.obolibrary.org/obo/OAE_0000434 lung AE pulmonary oedema AE a lung disorder AE that has an outcome of edema or abnormal buildup of fluid in the air sacs of the lungs, leads to shortness of breath http://purl.obolibrary.org/obo/OAE_0001360 rectal hemorrhage AE http://purl.obolibrary.org/obo/OAE_0000439 digestive system AE rectal haemorrhage AE Digestive System AE that results in bleeding in the rectal area http://purl.obolibrary.org/obo/OAE_0001364 renal failure AE http://purl.obolibrary.org/obo/OAE_0000328 kidney AE renal insufficiency AE a kidney disorder AE that results in kidneys failing to adequately filter toxins and waste from the blood http://purl.obolibrary.org/obo/OAE_0001365 acute kidney injury AE http://purl.obolibrary.org/obo/OAE_0000328 kidney AE renal failure acute AE a kidney disorder AE that results in the rapid loss or decline of kidney function http://purl.obolibrary.org/obo/OAE_0001370 respiratory acidosis AE http://purl.obolibrary.org/obo/OAE_0000378 respiratory system AE respiratory failure AE a respiratory system AE that has an outcome of a condition where lungs cannot remove all the carbon dioxide the body produces, makes body fluid too acidic http://purl.obolibrary.org/obo/OAE_0001430 gastric hemorrhage AE http://purl.obolibrary.org/obo/OAE_0000416 gastrointestinal hemorrhage AE gastric haemorrhage AE A gastrointestinal hemorrhage AE that has an outcome of the bleeding in the stomach http://purl.obolibrary.org/obo/OAE_0001461 toothache AE http://purl.obolibrary.org/obo/OAE_0000518 bone AE odontalgia AE a bone disorder AE that has an outcome of an aching pain in or around a tooth http://purl.obolibrary.org/obo/OAE_0001478 tumor lysis syndrome AE http://purl.obolibrary.org/obo/OAE_0000364 syndrome AE tumour lysis syndrome AE a syndrome AE that has an outcome of a group of metabolic complications that can occur after treatment of cancer http://purl.obolibrary.org/obo/OAE_0001481 ulcerative keratitis AE http://purl.obolibrary.org/obo/OAE_0003239 keratitis AE corneal ulcer AE a keratitis AE that has an outcome of disrupted epithelial layer and stroma of the cornea, may become blind http://purl.obolibrary.org/obo/OAE_0001484 upper gastrointestinal hemorrhage AE http://purl.obolibrary.org/obo/OAE_0000416 gastrointestinal hemorrhage AE upper gastrointestinal haemorrhage AE a gastrointestinal hemorrhage AE that has an outcome of bleeding in the upper gastrointestinal tract http://purl.obolibrary.org/obo/OAE_0001497 uterine hemorrhage AE http://purl.obolibrary.org/obo/OAE_0004304 uterine AE uterine haemorrhage AE a uterine AE that has an outcome of bleeding from the uterus http://purl.obolibrary.org/obo/OAE_0001502 vein discoloration AE http://purl.obolibrary.org/obo/OAE_0000184 dementia AE vein discolouration AE a vascular disorder AE that results in the veins becoming discoloured http://purl.obolibrary.org/obo/OAE_0001509 vision blurred AE http://purl.obolibrary.org/obo/OAE_0000578 abnormal vision AE blurred vision AE an abnormal vision AE that results in unclear vision http://purl.obolibrary.org/obo/OAE_0001515 weight increased AE http://purl.obolibrary.org/obo/OAE_0001644 physical examination result abnormal AE weight gain AE a physical examination result abnormal AE that shows an increase (gain) in weight of a patient http://purl.obolibrary.org/obo/OAE_0001526 mucosal inflammation AE http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE oral mucositis An inflammation AE that has an outcome of tissue swelling and other inflammatory response in the mouth http://purl.obolibrary.org/obo/OAE_0001531 restrictive cardiomyopathy AE http://purl.obolibrary.org/obo/OAE_0000785 cardiomyopathy AE infiltrative cardiomyopathy A cardiomyopathy AE that has an outcome of a condition that the heart cannot relax normally during the time between heartbeats when the blood returns from the body (diastole). http://purl.obolibrary.org/obo/OAE_0001538 ventricular fibrillation AE http://purl.obolibrary.org/obo/OAE_0000660 arrhythmia AE VF An arrythmia AE that has an outcome of a severely abnormal heart rhythm (arrhythmia) that can be life-threatening. http://purl.obolibrary.org/obo/OAE_0001539 first degree atrioventricular block AE http://purl.obolibrary.org/obo/OAE_0001297 atrioventricular block AE first degree heart block an atrioventricular block AE that there is some prolongation of AV conduction time (PR interval). The heart's electrical signals are slowed as they move from the atria to the ventricles (the heart's upper and lower chambers, respectively). This results in a longer, flatter line between the P and the R waves on the EKG (electrocardiogram). http://purl.obolibrary.org/obo/OAE_0001551 brain AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event brain disorder AE an adverse event that occurs in brain. http://purl.obolibrary.org/obo/OAE_0001571 second degree atrioventricular block AE http://purl.obolibrary.org/obo/OAE_0001297 atrioventricular block AE second degree heart block an atrioventricular block AE that some but not all atrial impulses fail to reach the ventricles, thus some ventricular beats are dropped. Electrical signals between the atria and ventricles are slowed to a large degree. Some signals don't reach the ventricles. On an EKG, the pattern of QRS waves doesn't follow each P wave as it normally would. http://purl.obolibrary.org/obo/OAE_0001576 complete atrioventricular block AE http://purl.obolibrary.org/obo/OAE_0001297 atrioventricular block AE third degree heart block an atrioventricular block AE that complete atrioventricular dissociation occurs; atria and ventricles beat independently. None of the electrical signals reach the ventricles. This type also is called complete heart block or complete AV block. When complete heart block occurs, special areas in the ventricles may create electrical signals to cause the ventricles to contract. This natural backup system is slower than the normal heart rate and isn't coordinated with the contraction of the atria. On an EKG, the normal pattern is disrupted. The P waves occur at a faster rate that isn't coordinated with the QRS waves. http://purl.obolibrary.org/obo/OAE_0001578 blood potassium increased http://purl.obolibrary.org/obo/PATO_0001018 physical quality hyperkalemia AE a physical quality where the blood potassium level is increased. http://purl.obolibrary.org/obo/OAE_0001587 urinary system investigation result abnormal AE http://purl.obolibrary.org/obo/OAE_0000628 investigation result abnormal AE renal system investigation result abnormal AE an investigation result abnormal AE that involves the renal and urinary tract and urinalyses http://purl.obolibrary.org/obo/OAE_0001603 Mobitz type I block AE http://purl.obolibrary.org/obo/OAE_0001571 second degree atrioventricular block AE type I second degree atrioventricular block a second degree atrioventricular block AE that the electrical signals are delayed more and more with each heartbeat, until the heart skips a beat. On the EKG, the delay is shown as a line (called the PR interval) between the P and QRS waves. The line gets longer and longer until the QRS waves don't follow the next P wave. http://purl.obolibrary.org/obo/OAE_0001641 Mobitz type II block AE http://purl.obolibrary.org/obo/OAE_0001571 second degree atrioventricular block AE type II second degree atrioventricular block a second degree atrioventricular block AE that some of the electrical signals don't reach the ventricles. However, the pattern is less regular than it is in Mobitz type I. Some signals move between the atria and ventricles normally, while others are blocked. On an EKG, the QRS wave follows the P wave at a normal speed. Sometimes, though, the QRS wave is missing (when a signal is blocked). http://purl.obolibrary.org/obo/OAE_0001664 hematology investigation result abnormal AE http://purl.obolibrary.org/obo/OAE_0000628 investigation result abnormal AE haematology investigation abnormal AE an investigation result abnormal AE that is characterized by an abnormal result of a hematology investigation http://purl.obolibrary.org/obo/OAE_0001743 cardiac embolism AE http://purl.obolibrary.org/obo/OAE_0001744 embolism AE heart embolism AE an embolism disorder AE that is a result of an obstruction in a cardiac vessel due to a blood clot or other foreign matters http://purl.obolibrary.org/obo/OAE_0001750 severity of adverse event http://purl.obolibrary.org/obo/PATO_0001236 process quality AE severity a process quality that represents the level of severity of an adverse event. http://purl.obolibrary.org/obo/OAE_0001783 superficial thrombophlebitis AE http://purl.obolibrary.org/obo/OAE_0001449 thrombophlebitis AE thrombophlebitis superficial AE a thrombophlebitis AE that is characterized by an inflammation of a vein due to a blood clot in a vein located just below the skin's surface. http://purl.obolibrary.org/obo/OAE_0001790 stroke AE http://purl.obolibrary.org/obo/OAE_0001551 brain AE cardiovascular accident AE a brain AE that occurs when flow of oxygen-rich blood to a portion of the brain is blocked http://purl.obolibrary.org/obo/OAE_0001797 psychiatric disorder AE http://purl.obolibrary.org/obo/OAE_0000580 behavioral and neurological AE mental disorder AE a behavior and neurological AE that has an outcome of a mental illness or psychiatiric disorder. The mental illness is a mental or behavioral pattern or anomaly that causes either suffering or an impaired ability to function in ordinary life (disability), and which is not developmentally or socially normative. http://purl.obolibrary.org/obo/OAE_0001836 AE severity G1 http://purl.obolibrary.org/obo/OAE_0001750 severity of adverse event AE severity Grade 1 a severity of AE that shows asymptomatic, or involves mild or minor symptoms, or is of marginal clinical relevance, or consists of clinical or diagnostic observations alone, or where intervention is not indicated, or where only non-prescription intervention is indicated. http://purl.obolibrary.org/obo/OAE_0001837 AE severity G2 http://purl.obolibrary.org/obo/OAE_0001750 severity of adverse event AE severity Grade 2 a severity of AE for which only minimal, local, or noninvasive intervention (e.g. packing, cautery) is indicated, or that limits instrumental activities of daily living (ADLs, e.g., shopping, laundry, transportation, or ability to conduct finances). http://purl.obolibrary.org/obo/OAE_0001838 AE severity G3 http://purl.obolibrary.org/obo/OAE_0001750 severity of adverse event AE severity Grade 3 a severity of AE that shows an outcome which is medically significant but not life-threatening; or for which inpatient care or prolongation of hospitalization are indicated; or that is an important medical event that does not result in hospitalization, but may jeopardize the patient or may require intervention either to prevent hospitalization, to prevent the AE from becoming life-threatening or causing death; or that is disabling; or that results in persistent or significant disability, incapacity, or limitation of self care activities of daily living (ADLs, getting in and out of bed, dressing, eating, getting around inside, bathing, or using the toilet). http://purl.obolibrary.org/obo/OAE_0001839 AE severity G4 http://purl.obolibrary.org/obo/OAE_0001750 severity of adverse event AE severity Grade 4 a severity of AE that has life-threatening consequences, for which urgent intervention is indicated, that puts the patient is at risk of death at the time of the event if immediate intervention is not undertaken, or that causes blindness or deafness (need to decide if unilateral or bilateral). http://purl.obolibrary.org/obo/OAE_0001840 AE severity G5 http://purl.obolibrary.org/obo/OAE_0001750 severity of adverse event AE severity Grade 5 a severity of AE that results in death. http://purl.obolibrary.org/obo/OAE_0001845 gastric disorder AE http://purl.obolibrary.org/obo/OAE_0000455 gastrointestinal disorder AE stomach disorder AE a gastrointestinal disorder AE that shows a problem with the stomach, ranging from indigestion and heartburn to peptic ulcers and GERD. http://purl.obolibrary.org/obo/OAE_0001857 urgent urination AE http://purl.obolibrary.org/obo/OAE_0000622 urinary system AE urinary urgency Urgent urination AE is a urinary system AE that has an outcome of a sudden, compelling urge to urinate, along with discomfort in the bladder. http://purl.obolibrary.org/obo/OAE_0001922 stomach ache AE http://purl.obolibrary.org/obo/OAE_0000402 abdominal pain AE stomachache AE Stomachache AE is a pain AE that the pain in or near your stomach. It is a common symptom associated with transient disorders or serious disease. http://purl.obolibrary.org/obo/OAE_0001937 renal calculus AE http://purl.obolibrary.org/obo/OAE_0000328 kidney AE renal calculi AE Renal calculus AE is a kidney AE that is a solid concretion or crystal aggregation formed in the kidneys from minerals in the urine. Kidney stones typically leave the body by passage in the urine stream, and many stones are formed and passed without causing symptoms. If stones grow to sufficient size (usually at least 3 millimeters (0.12 in)) they can cause blockage of the ureter. This leads to pain, most commonly beginning in the flank or lower back and often radiating to the groin or genitals. http://purl.obolibrary.org/obo/OAE_0001978 akathisia AE http://purl.obolibrary.org/obo/OAE_0000580 behavioral and neurological AE acathisia AE Akathisia AE is a behavior and neurological AE that is a movement disorder characterized by a feeling of inner restlessness and a compelling need to be in constant motion, as well as by actions such as rocking while standing or sitting, lifting the feet as if marching on the spot, and crossing and uncrossing the legs while sitting. People with akathisia are unable to sit or keep still, complain of restlessness, fidget, rock from foot to foot, and pace. http://purl.obolibrary.org/obo/OAE_0001986 hearing loss AE http://purl.obolibrary.org/obo/OAE_0002129 hearing disorder AE hearing impairment AE a hearing disorder AE that is a partial or total inability to hear. In children it may affect the development of language and can cause work related difficulties for adults. http://purl.obolibrary.org/obo/OAE_0001993 toxic epidermal necrolysis AE http://purl.obolibrary.org/obo/OAE_0000543 skin AE Lyell's syndrome AE Toxic epidermal necrolysis AE is a skin AE that is a rare, life-threatening skin condition which is usually caused by a reaction to drugs. http://purl.obolibrary.org/obo/OAE_0002088 international normalized ratio increased AE http://purl.obolibrary.org/obo/OAE_0001664 hematology investigation result abnormal AE INR increased AE a lab test abnormal AE that has an outcome of an increased international normalized ratio, indicating an individual is more prone to bleeding http://purl.obolibrary.org/obo/OAE_0002095 fecal incontinence AE http://purl.obolibrary.org/obo/OAE_0000603 abnormal defecation AE faecal incontinence AE an abnormal defecation AE that has an outcome of fecal incontinence, the accidental passing of solid or liquid stool or mucus from the rectum http://purl.obolibrary.org/obo/OAE_0002116 thrombotic thrombocytopenic purpura AE http://purl.obolibrary.org/obo/OAE_0000480 thrombocytopenic purpura AE moschcowitz syndrome AE Thrombotic thrombocytopenic purpura AE is a thrombocytopenic purpura AE that is a rare disorder of the blood-coagulation system, causing extensive microscopic clots to form in the small blood vessels throughout the body. http://purl.obolibrary.org/obo/OAE_0002120 hyponatremia AE http://purl.obolibrary.org/obo/OAE_0001579 blood sodium abnormal AE hyponatraemia AE a blood sodium abnormal AE with an abnormally decreased sodium concentration in the blood http://purl.obolibrary.org/obo/OAE_0002122 angina AE http://purl.obolibrary.org/obo/OAE_0000406 chest pain AE tight chest AE a chest pain that is caused when your heart muscle doesn't get enough oxygen-rich blood. http://purl.obolibrary.org/obo/OAE_0002241 laryngeal edema AE http://purl.obolibrary.org/obo/OAE_0000556 edema AE laryngeal oedema AE Laryngeal edema AE is an edema AE that shows abnormal accumulation of fluid in tissues of any part of the larynx, commonly associated with laryngeal injuries and allergic reactions. http://purl.obolibrary.org/obo/OAE_0002331 acidosis AE http://purl.obolibrary.org/obo/OAE_0000069 metabolism, endocrine or exocrine system AE Blood pH Decreased a metabolism, endocrine, and exocrine system AE that has an outcome of acidosis, i.e., too much acid in the body fluids. http://purl.obolibrary.org/obo/OAE_0002371 atrial tachycardia AE http://purl.obolibrary.org/obo/OAE_0000355 tachycardia AE supraventricular tachycardia atrial tachycardia AE is a tachycardia AE that results in a fast heart rate beginning in the upper chambers of the heart http://purl.obolibrary.org/obo/OAE_0002439 menstruation irregular AE http://purl.obolibrary.org/obo/OAE_0002421 menstrual disorder AE irregular menstruation AE Menstruation irregular AE is a endocrine system AE that is an abnormal variation in length of menstrual cycles in a female. http://purl.obolibrary.org/obo/OAE_0002453 buttock pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE Butt Pain Buttock pain AE is a pain AE that is a common problem in the butt, it can be due to bursitis, bruising, piriformis syndrome, and shingles,or due to more serious diseases with long-term consequences, such as cancer, arthritis of the sacroiliac joints, and herniated disc with sciatica. http://purl.obolibrary.org/obo/OAE_0002468 cerebrospinal fluid leak AE http://purl.obolibrary.org/obo/OAE_0000570 nervous system AE cerebrospinal fluid leakage AE a nervous system AE that occurs when the cerebrospinal fluid leaks through a defect in the dura or the skull and out through the nose or ear resulting from a tear in the dura. http://purl.obolibrary.org/obo/OAE_0002521 muscle spasticity AE http://purl.obolibrary.org/obo/OAE_0000521 muscle spasm AE spasticity AE A muscle spasm AE that has an outcome of tight or stiff muscles and an inability to control those muscles. http://purl.obolibrary.org/obo/OAE_0002538 hypernatremia AE http://purl.obolibrary.org/obo/OAE_0001579 blood sodium abnormal AE hypernaetremia a blood sodium abnormal AE that is characterized by an abnormally high level of sodium in the blood http://purl.obolibrary.org/obo/OAE_0002549 skin hypopigmentation AE http://purl.obolibrary.org/obo/OAE_0000423 skin discoloration AE Hypopigmentation, Pigment Dilution A skin discoloration AE that shows abnormal lightening of skin due to decreased melanin production or deposition. http://purl.obolibrary.org/obo/OAE_0002550 spleen disorder AE http://purl.obolibrary.org/obo/OAE_0000476 immune system AE splenic diseases An immune system disorder AE that has an disorder in spleen, the largest organ in the lymphatic system. http://purl.obolibrary.org/obo/OAE_0002582 hypokalaemia AE http://purl.obolibrary.org/obo/OAE_0001577 blood potassium abnormal AE potassium depletion AE a blood potassium abnormal AE that has a lab test outcome of abnormally lower than normal amount of potassium in the blood http://purl.obolibrary.org/obo/OAE_0002599 acneiform rash AE http://purl.obolibrary.org/obo/OAE_0000362 rash AE rash acneiform AE a rash AE that shows follicular eruptions characterized by papules and pustules resembling acne. http://purl.obolibrary.org/obo/OAE_0002605 thromboembolism AE http://purl.obolibrary.org/obo/OAE_0000085 vascular disorder AE thromboembolic event AE a vascular disorder AE that form in a blood vessel a clot (thrombus) that breaks loose and is carried by the blood stream to plug another vessel. http://purl.obolibrary.org/obo/OAE_0002626 injury or procedural complication AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event injury and procedural complication AE an adverse event that shows a result of injury or procedural complication. http://purl.obolibrary.org/obo/OAE_0003238 asystole AE http://purl.obolibrary.org/obo/OAE_0000461 cardiac arrest asystole a cardiac arrest AE where there is no discernible electrical activity on the ECG monitor. http://purl.obolibrary.org/obo/OAE_0000001 adverse event http://purl.obolibrary.org/obo/OGMS_0000061 pathological bodily process adverse reaction a pathological bodily process that occurs after a medical intervention. An adverse event is likely caused by the medical intervention; however, such a causal association is not required to be an adverse event. http://purl.obolibrary.org/obo/OAE_0000631 serious adverse event http://purl.obolibrary.org/obo/OAE_0000001 adverse event serious adverse event serious adverse event is an adverse event that requires in-patient hospitalization, or prolongation of existing hospitalization, or that causes congenital malformation, or that results in persistent or significant disability or incapacity, or that is life threatening or results in death. http://purl.obolibrary.org/obo/OAE_0002547 skin atrophy AE http://purl.obolibrary.org/obo/OAE_0000543 skin AE atrophy of the skin A skin AE that results in the degeneration and thinning of the epidermis and dermis. http://purl.obolibrary.org/obo/OAE_0000002 medical intervention http://purl.obolibrary.org/obo/OBI_0000011 planned process medical intervention is a planned process that has the goal of diagnosing, preventing or relieving illness or injury. http://purl.obolibrary.org/obo/OAE_0000021 flushing AE http://purl.obolibrary.org/obo/OAE_0000423 skin discoloration AE a skin discoloration AE which has an outcome of flushing, a sudden reddening of the face, neck, or upper chest http://purl.obolibrary.org/obo/OAE_0000022 pain in extremity AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE where the pain reachs an extreme level. http://purl.obolibrary.org/obo/OAE_0000038 myocardial infarction AE http://purl.obolibrary.org/obo/OAE_0000084 cardiac disorder AE a cardiac disorder AE that is characterized by a necrosis of the myocardium caused by an obstruction of the blood supply to the heart http://purl.obolibrary.org/obo/OAE_0000041 injury AE http://purl.obolibrary.org/obo/OAE_0002626 injury or procedural complication AE an injury and procedural complication AE which has an outcome of injury http://purl.obolibrary.org/obo/OAE_0000048 nystagmus AE http://purl.obolibrary.org/obo/OAE_0000443 eye AE Nystagmus AE is an eye AE that is a condition of involuntary eye movement, acquired in infancy or later in life, that may result in reduced or limited vision. Due to the involuntary movement of the eye, it is often called "dancing eyes". http://purl.obolibrary.org/obo/OAE_0000053 wheezing AE http://purl.obolibrary.org/obo/OAE_0000378 respiratory system AE a respiratory system AE which has an outcome of wheezing, a high-pitched whistling sound made while breathing. http://purl.obolibrary.org/obo/OAE_0000082 female reproductive system AE http://purl.obolibrary.org/obo/OAE_0000651 reproductive system AE a reproductive system AE that occurs on the female side. http://purl.obolibrary.org/obo/OAE_0000083 male reproductive system AE http://purl.obolibrary.org/obo/OAE_0000651 reproductive system AE a reproductive system AE that occurs on the male side. http://purl.obolibrary.org/obo/OAE_0000084 cardiac disorder AE http://purl.obolibrary.org/obo/OAE_0000493 cardiovascular AE a cardiovascular disorder AE that has a cardiac disorder outcome. http://purl.obolibrary.org/obo/OAE_0000085 vascular disorder AE http://purl.obolibrary.org/obo/OAE_0000493 cardiovascular AE a cardiovascular disorder AE that has a vascular disorder outcome http://purl.obolibrary.org/obo/OAE_0000166 tremor AE http://purl.obolibrary.org/obo/OAE_0000580 behavioral and neurological AE Tremor AE is a behavior and neurological AE that has an outcome of an involuntary trembling or quivering, and muscle contraction and relaxation. http://purl.obolibrary.org/obo/OAE_0000168 motor neuropathy AE http://purl.obolibrary.org/obo/OAE_0000418 neuropathy AE a peripheral neuropathy AE which is caused by a damage to motor neurons http://purl.obolibrary.org/obo/OAE_0000184 dementia AE http://purl.obolibrary.org/obo/OAE_0001797 psychiatric disorder AE a psychiatric disorder AE that has an outcome of a loss of brain function and causes a long term and often gradual decrease in the ability to think and remember such that a person's daily functioning is affected. http://purl.obolibrary.org/obo/OAE_0000185 thrombosis AE http://purl.obolibrary.org/obo/OAE_0000085 vascular disorder AE A vascular disorder AE that results in the presence of blood clot along the wall of a blood vessel, frequently causing vascular obstruction. Some authorities differentiate thrombus formation from simple coagulation or clot formation. http://purl.obolibrary.org/obo/OAE_0000187 cell death AE http://purl.obolibrary.org/obo/OAE_0001172 metabolic disorder AE a metabolic disorder AE that has an outcome of cell death. http://purl.obolibrary.org/obo/OAE_0000194 phlebitis AE http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE an inflammation AE that shows the result of an inflammation located in a vein, usually in the legs. http://purl.obolibrary.org/obo/OAE_0000195 pancreatitis AE http://purl.obolibrary.org/obo/OAE_0000436 hepatobiliary or pancreatic AE a liver, biliary, and pancreatic AE that has an outcome of pancreatitis. http://purl.obolibrary.org/obo/OAE_0000197 necrosis AE http://purl.obolibrary.org/obo/OAE_0000187 cell death AE a cell death AE that has an outcome of necrosis http://purl.obolibrary.org/obo/OAE_0000200 hair AE http://purl.obolibrary.org/obo/OAE_0000199 hair, skin or nail AE a hair, skin, and nail AE that occurs in hair. http://purl.obolibrary.org/obo/OAE_0000201 nail AE http://purl.obolibrary.org/obo/OAE_0000199 hair, skin or nail AE a hair, skin, and nail AE that occurs in nail. http://purl.obolibrary.org/obo/OAE_0000202 endocrine system AE http://purl.obolibrary.org/obo/OAE_0000069 metabolism, endocrine or exocrine system AE a metabolism, endocrine, and exocrine system AE that occurs in endocrine system. http://purl.obolibrary.org/obo/OAE_0000205 paresis AE http://purl.obolibrary.org/obo/OAE_0000581 movement disorder AE a muscular weakness AE that shows weakness or inability to move a body part, often used to describe a neurologic condition. http://purl.obolibrary.org/obo/OAE_0000210 hepatitis AE http://purl.obolibrary.org/obo/OAE_0000562 liver inflammation AE a liver, biliary, and pancreatic AE that has an outcome of hepatitis. http://purl.obolibrary.org/obo/OAE_0000211 ulcer AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event an adverse event that displays an outcome of ulcer. http://purl.obolibrary.org/obo/OAE_0000212 fistula AE http://purl.obolibrary.org/obo/OAE_0000027 musculoskeletal or connective tissue AE a musculoskeletal and connective tissue AE that displays an outcome of fistula, a permanent abnormal passageway between two organs in the body or between an organ and the exterior of the body. http://purl.obolibrary.org/obo/OAE_0000218 bradycardia AE http://purl.obolibrary.org/obo/OAE_0000621 decreased heart rate AE a decreased heart rate AE that results in a resting heart rate of under 60 beats per minutes (BPM). http://purl.obolibrary.org/obo/OAE_0000227 medical intervention site http://purl.obolibrary.org/obo/BFO_0000029 site a site that is used for a medical intervention http://purl.obolibrary.org/obo/OAE_0000232 perinatal AE http://purl.obolibrary.org/obo/OAE_0000219 prenatal, perinatal or neonatal disorder AE A pregnancy, neonatal and perinatal AE that displays a disorder associated with childbirth http://purl.obolibrary.org/obo/OAE_0000243 abdominal distension AE http://purl.obolibrary.org/obo/OAE_0000582 sensory capability AE a sensory capability AE that results in a sensation of elevated abdominal pressure and volume http://purl.obolibrary.org/obo/OAE_0000252 activated partial thromboplastin time prolonged AE http://purl.obolibrary.org/obo/OAE_0000588 hematopoietic system AE a hematopoietic system AE that has an outcome of a prolonged time taken for blood to clot. The partial thromboplastin time (PTT) is a blood test that looks at how long it takes for blood to clot. PTT measures the efficacy of the comon coagulation pathways and helps tell if bleeding or clotting problems exist. http://purl.obolibrary.org/obo/OAE_0000270 alanine aminotransferase level abnormal AE http://purl.obolibrary.org/obo/OAE_0001694 liver related investigation result abnormal AE a liver related investigation result abnormal AE that has an outcome of an abnormal blood level of alanine aminotransferase http://purl.obolibrary.org/obo/OAE_0000272 alanine aminotransferase level increased AE http://purl.obolibrary.org/obo/OAE_0000270 alanine aminotransferase level abnormal AE an alanine aminotransferase level abnormal AE that has an outcome of elevated levels of alanine transaminase, an enzyme most commonly found in the liver http://purl.obolibrary.org/obo/OAE_0000278 anal ulcer AE http://purl.obolibrary.org/obo/OAE_0000211 ulcer AE an ulcer AE that has an outcome of an ulcer in the anal cavity http://purl.obolibrary.org/obo/OAE_0000300 anxiety AE http://purl.obolibrary.org/obo/OAE_0001797 psychiatric disorder AE a psychiatric disorder AE that has an outcome of a psychological and physiological state characterized by cognitive, somatic, emotional, and behavioral components. These components combine to create an unpleasant feeling that is typically associated with uneasiness, fear, or worry. http://purl.obolibrary.org/obo/OAE_0000308 dysgeusia AE http://purl.obolibrary.org/obo/OAE_0000580 behavioral and neurological AE a behavior and neurological AE that has an outcome of distortion of the sense of taste http://purl.obolibrary.org/obo/OAE_0000320 arteriosclerosis coronary artery AE http://purl.obolibrary.org/obo/OAE_0001161 coronary artery disorder AE a coronary artery disease AE with the outcome hardening of the coronary artery due to a build up of waxy plaque on the inside of blood vessels http://purl.obolibrary.org/obo/OAE_0000332 mobility decreased AE http://purl.obolibrary.org/obo/OAE_0000570 nervous system AE mobility decreased AE is a nervous system AE that results in difficulty in movement leading to less ability to move part(s) of body http://purl.obolibrary.org/obo/OAE_0000333 muscular weakness AE http://purl.obolibrary.org/obo/OAE_0000435 muscle AE a muscle AE that has an outcome of muscular weakness AE (i.e., lack of muscle strength). http://purl.obolibrary.org/obo/OAE_0000335 nasal congestion AE http://purl.obolibrary.org/obo/OAE_0000378 respiratory system AE nasal congestion AE is a respiratory system AE that results in a blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels http://purl.obolibrary.org/obo/OAE_0000340 otitis media AE http://purl.obolibrary.org/obo/OAE_0000465 ear AE an ear disorder AE which has an outcome of otitis media that results in inflammation of the middle ear, or middle ear infection http://purl.obolibrary.org/obo/OAE_0000341 pericarditis AE http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE an inflammation AE that has an outcome of pericaditis, which is a cardiovascular disorder that results in a condition in which the sac-like covering around the heart (pericardium) becomes inflamed http://purl.obolibrary.org/obo/OAE_0000343 pharyngitis AE http://purl.obolibrary.org/obo/OAE_0000439 digestive system AE pharyngitis AE is a digestive system AE that results in an inflammation of the throat or pharynx http://purl.obolibrary.org/obo/OAE_0000344 pharyngolaryngeal pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that shows a pain in sinus and throat http://purl.obolibrary.org/obo/OAE_0000355 tachycardia AE http://purl.obolibrary.org/obo/OAE_0000590 increased heart rate AE an increased heart rate AE where the heart rate exceeds the normal range for a resting heartrate (heartrate in an inactive or sleeping individual) http://purl.obolibrary.org/obo/OAE_0000362 rash AE http://purl.obolibrary.org/obo/OAE_0000543 skin AE a skin AE that shows the symptom of rash, i.e., an abnormal change in skin color, appearance, or texture. A rash may cause the skin to change color, itch, become warm, bumpy, dry, cracked or blistered, swell and may be painful. http://purl.obolibrary.org/obo/OAE_0000364 syndrome AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event An AE that has an outcome of syndrome. Syndrome is the association of several clinically recognizable features, signs (observed by a physician), symptoms (reported by the patient), phenomena or characteristics that often occur together, so that the presence of one feature alerts the physician to the presence of the others. http://purl.obolibrary.org/obo/OAE_0000365 agitation AE http://purl.obolibrary.org/obo/OAE_0001797 psychiatric disorder AE a psychiatric disorder AE that has an outcome of emotional state of excitement or restlessness http://purl.obolibrary.org/obo/OAE_0000374 pain AE http://purl.obolibrary.org/obo/OAE_0000582 sensory capability AE a sensory capability AE that has an outcome of pain in a patient http://purl.obolibrary.org/obo/OAE_0000377 headache AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has an outcome of headache http://purl.obolibrary.org/obo/OAE_0000378 respiratory system AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event an AE that occurs in respiratory system. http://purl.obolibrary.org/obo/OAE_0000381 abnormal blood pressure AE http://purl.obolibrary.org/obo/OAE_0000493 cardiovascular AE a cardiovascular disorder AE that has an outcome of abnormal blood pressure, representing altered tension of the blood within the systemic arteries http://purl.obolibrary.org/obo/OAE_0000385 arthralgia AE http://purl.obolibrary.org/obo/OAE_0000442 joint disorder AE An joint disorder AE that has an outcome of arthralgia. Arthralgia means joint pain. It is a symptom of injury, infection, illnesses (in particular arthritis) or an allergic reaction to medication. According to MeSH, the term "arthralgia" should only be used when the condition is non-inflammatory, and the term "arthritis" should be used when the condition is inflammatory. http://purl.obolibrary.org/obo/OAE_0000388 dizziness AE http://purl.obolibrary.org/obo/OAE_0000582 sensory capability AE a sensory capability AE that has an outcome of dizziness http://purl.obolibrary.org/obo/OAE_0000390 malaise AE http://purl.obolibrary.org/obo/OAE_0000582 sensory capability AE a sensory capability AE that has an outcome of malaise http://purl.obolibrary.org/obo/OAE_0000401 sweating AE http://purl.obolibrary.org/obo/OAE_0000543 skin AE a skin adverse event that has an outcome of sweating http://purl.obolibrary.org/obo/OAE_0000406 chest pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that occurs at the chest http://purl.obolibrary.org/obo/OAE_0000412 neck pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has an outcome of neck pain http://purl.obolibrary.org/obo/OAE_0000414 back pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has an outcome of back pain http://purl.obolibrary.org/obo/OAE_0000415 alopecia AE http://purl.obolibrary.org/obo/OAE_0000200 hair AE a hair AE that has an outcome of alopecia and occurs after a medical intervention. http://purl.obolibrary.org/obo/OAE_0000418 neuropathy AE http://purl.obolibrary.org/obo/OAE_0000570 nervous system AE a nervous system AE that shows a damage to or disease affecting the nerves. http://purl.obolibrary.org/obo/OAE_0000426 speech disorder AE http://purl.obolibrary.org/obo/OAE_0000580 behavioral and neurological AE a behavior and neurological AE that has an outcome of disorder in speech http://purl.obolibrary.org/obo/OAE_0000435 muscle AE http://purl.obolibrary.org/obo/OAE_0000027 musculoskeletal or connective tissue AE a musculoskeletal system AE that occurs in muscle. http://purl.obolibrary.org/obo/OAE_0000438 meningitis AE http://purl.obolibrary.org/obo/OAE_0002629 meninges inflammation AE a brain inflammation AE which results in an inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges. The inflammation is caused by infection with viruses, bacteria, or other microorganisms, and less commonly by certain drugs or diseases. http://purl.obolibrary.org/obo/OAE_0000439 digestive system AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event an AE that occurs in digestive system. http://purl.obolibrary.org/obo/OAE_0000442 joint disorder AE http://purl.obolibrary.org/obo/OAE_0000027 musculoskeletal or connective tissue AE a musculoskeletal system AE which has an outcome of joint disorder http://purl.obolibrary.org/obo/OAE_0000449 erythema multiforme AE http://purl.obolibrary.org/obo/OAE_0000362 rash AE a rash AE which shows red, target-shaped or "bulls-eye" patches or sores on the skin. http://purl.obolibrary.org/obo/OAE_0000453 dyspepsia AE http://purl.obolibrary.org/obo/OAE_0000554 abnormal digestion AE an abnormal digestion AE which has an outcome of dyspepsia http://purl.obolibrary.org/obo/OAE_0000455 gastrointestinal disorder AE http://purl.obolibrary.org/obo/OAE_0000439 digestive system AE a digestive system AE which has an outcome of a gastrointestinal disorder http://purl.obolibrary.org/obo/OAE_0000456 ascites AE http://purl.obolibrary.org/obo/OAE_0000556 edema AE an edema AE that has an outcome of accumulation of fluid in the peritoneal cavity http://purl.obolibrary.org/obo/OAE_0000457 serum sickness AE http://purl.obolibrary.org/obo/OAE_0000584 hypersensitivity AE a hypersensitivity AE which has an outcome of serum sickness http://purl.obolibrary.org/obo/OAE_0000460 vertigo AE http://purl.obolibrary.org/obo/OAE_0000388 dizziness AE a dizziness AE that has an outcome of vertigo http://purl.obolibrary.org/obo/OAE_0000470 eye pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has an outcome of eye pain http://purl.obolibrary.org/obo/OAE_0000473 ear pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has an outcome of ear pain http://purl.obolibrary.org/obo/OAE_0000478 myelitis AE http://purl.obolibrary.org/obo/OAE_0000570 nervous system AE a nervous system AE which involves inflammation of the spinal cord, which disrupts central nervous system functions linking the brain and limbs. http://purl.obolibrary.org/obo/OAE_0000480 thrombocytopenic purpura AE http://purl.obolibrary.org/obo/OAE_0000487 purpura AE Thrombocytopenic purpura AE are purpura AE associated with a reduction in circulating blood platelets which can result from a variety of causes. http://purl.obolibrary.org/obo/OAE_0000482 amnesia AE http://purl.obolibrary.org/obo/OAE_0000580 behavioral and neurological AE a behavior and neurological AE that has an outcome of amnesia in a patient http://purl.obolibrary.org/obo/OAE_0000484 voice alteration AE http://purl.obolibrary.org/obo/OAE_0000426 speech disorder AE a speech disorder that has an outcome of voice alteration http://purl.obolibrary.org/obo/OAE_0000487 purpura AE http://purl.obolibrary.org/obo/OAE_0000423 skin discoloration AE a skin discoloration AE which has an outcome of purpura http://purl.obolibrary.org/obo/OAE_0000490 acute brain syndrome AE http://purl.obolibrary.org/obo/OAE_0000364 syndrome AE a syndrome AE that has an outcome of an acute brain syndrome AE and occurs after a medical intervention. http://purl.obolibrary.org/obo/OAE_0000494 encephalopathy AE http://purl.obolibrary.org/obo/OAE_0000570 nervous system AE a nervous system AE which has an outcome of encephalopathy, which is disorder or disease of the brain. http://purl.obolibrary.org/obo/OAE_0000495 urine abnormality AE http://purl.obolibrary.org/obo/OAE_0000622 urinary system AE a urinary system AE that has an outcome of urine abnormality AE http://purl.obolibrary.org/obo/OAE_0000498 urinary tract infection AE http://purl.obolibrary.org/obo/OAE_0000622 urinary system AE a urinary system AE that has an outcome of urnary tract infection AE http://purl.obolibrary.org/obo/OAE_0000500 depression AE http://purl.obolibrary.org/obo/OAE_0001797 psychiatric disorder AE a psychiatric disorder AE that has an outcome of depression. Depression causes a persistent feeling of sadness and loss of interest. http://purl.obolibrary.org/obo/OAE_0000502 laryngitis AE http://purl.obolibrary.org/obo/OAE_0000564 respiratory system inflammation AE a respiratory system inflammation AE which has an outcome of laryngitis http://purl.obolibrary.org/obo/OAE_0000510 photophobia AE http://purl.obolibrary.org/obo/OAE_0000443 eye AE an eye disorder AE which has an outcome of photophobia http://purl.obolibrary.org/obo/OAE_0000514 neuralgia AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has an outcome of neuralgia http://purl.obolibrary.org/obo/OAE_0000519 fetal disorder AE http://purl.obolibrary.org/obo/OAE_0000232 perinatal AE a perinatal AE that displays fetal disorder. http://purl.obolibrary.org/obo/OAE_0000521 muscle spasm AE http://purl.obolibrary.org/obo/OAE_0000435 muscle AE a muscle adverse event which has an outcome of muscle spasm, which is an involuntary and often painful muscle contraction or cramps having a number of causes ranging from nutritional deficiency to serious nervous system conditions http://purl.obolibrary.org/obo/OAE_0000533 bone pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has an outcome of bone pain http://purl.obolibrary.org/obo/OAE_0000536 flatulence AE http://purl.obolibrary.org/obo/OAE_0000581 movement disorder AE a movement disorder AE that has an outcome of flatulence http://purl.obolibrary.org/obo/OAE_0000538 sore throat AE http://purl.obolibrary.org/obo/OAE_0000378 respiratory system AE a respiratory system AE which has an outcome of sore throat http://purl.obolibrary.org/obo/OAE_0000539 paralysis AE http://purl.obolibrary.org/obo/OAE_0000581 movement disorder AE a movement disorder AE that results in the loss of power of voluntary movement in a muscle through injury or disease of its nerve supply http://purl.obolibrary.org/obo/OAE_0000543 skin AE http://purl.obolibrary.org/obo/OAE_0000199 hair, skin or nail AE a hair, skin, and nail AE that occurs in skin. http://purl.obolibrary.org/obo/OAE_0000546 abnormal fluid regulation AE http://purl.obolibrary.org/obo/OAE_0000555 homeostasis AE a homeostasis AE which has an outcome of abnormal fluid regulation, which is any anomaly in the control of intracellular and/or extracellular fluid http://purl.obolibrary.org/obo/OAE_0000547 hyperglycemia AE http://purl.obolibrary.org/obo/OAE_0000583 glucose homeostasis AE a glucose homeostasis AE which has an outcome of hyperglycemia, which is an abnormally high concentration of glucose in the blood; generally refers to a pathological state http://purl.obolibrary.org/obo/OAE_0000553 electrolyte blood test abnormal AE http://purl.obolibrary.org/obo/OAE_0001573 electrolyte lab test abnormal AE an electrolyte lab test abnormal AE that shows an abnormal level of an electrolyte in the blood http://purl.obolibrary.org/obo/OAE_0000554 abnormal digestion AE http://purl.obolibrary.org/obo/OAE_0000439 digestive system AE a digestive system AE which has an outcome of abnormal digestion, which is an altered ability of the mechanical, chemical, and enzymatic processes of the body to convert ingested food into material suitable for assimilation for synthesis of tissues or liberation of energy http://purl.obolibrary.org/obo/OAE_0000555 homeostasis AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event an AE that occurs in the homeostasis system. http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE http://purl.obolibrary.org/obo/OAE_0000476 immune system AE an immune system disorder AE that results in complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Inflammation is a protective attempt by the organism to remove the injurious stimuli as well as initiate the healing process for the tissue greater than expected response to injury, infection, or insult. http://purl.obolibrary.org/obo/OAE_0000558 brain inflammation AE http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE an inflammation AE which has an outcome of brain inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the brain http://purl.obolibrary.org/obo/OAE_0000560 eye inflammation AE http://purl.obolibrary.org/obo/OAE_0000443 eye AE an eye disorder AE which has an outcome of eye inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the eye http://purl.obolibrary.org/obo/OAE_0000561 conjunctivitis AE http://purl.obolibrary.org/obo/OAE_0000560 eye inflammation AE an eye inflammation AE which has an outcome of conjunctivitis, which is inflammation of the mucous membrane that lines the inner surface of the eyelids and the front of the eyeball http://purl.obolibrary.org/obo/OAE_0000562 liver inflammation AE http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE an inflammation AE that shows a local accumulation of fluid, plasma proteins, and leukocytes in the liver http://purl.obolibrary.org/obo/OAE_0000563 lung inflammation AE http://purl.obolibrary.org/obo/OAE_0000564 respiratory system inflammation AE aa inflammation AE which has an outcome of lung inflammation, a local accumulation of fluid, plasma proteins, and leukocytes in the lung http://purl.obolibrary.org/obo/OAE_0000564 respiratory system inflammation AE http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE an inflammation AE which occurs in the respiratory system, which is reflected with the local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system http://purl.obolibrary.org/obo/OAE_0000565 vasculitis AE http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE an inflammation AE that has an outcome of vasculitis, which is an inflammation of a blood or lymph vessel http://purl.obolibrary.org/obo/OAE_0000571 abnormal respiration AE http://purl.obolibrary.org/obo/OAE_0000378 respiratory system AE a respiratory system AE which has an outcome of abnormal respiration, an anomaly in the movement of gases into and out of the lung http://purl.obolibrary.org/obo/OAE_0000574 gustatory system AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event an adverse event that occurs in a gustatory system http://purl.obolibrary.org/obo/OAE_0000578 abnormal vision AE http://purl.obolibrary.org/obo/OAE_0000443 eye AE an eye disorder AE which has an outcome of abnormal vision, which is an inability or decreased ability to see http://purl.obolibrary.org/obo/OAE_0000579 seizure AE http://purl.obolibrary.org/obo/OAE_0000580 behavioral and neurological AE a behavior and neurological AE that shows a sudden surge of electrical activity in the brain. http://purl.obolibrary.org/obo/OAE_0000581 movement disorder AE http://purl.obolibrary.org/obo/OAE_0000580 behavioral and neurological AE a behavior and neurological AE that has an outcome of altered ability to coordinate voluntary movement or repetitive, compulsive movements http://purl.obolibrary.org/obo/OAE_0000583 glucose homeostasis AE http://purl.obolibrary.org/obo/OAE_0000555 homeostasis AE a homeostasis AE which has an outcome of glucose homeostasis, which is an anomaly in the processes involved in the maintenance of an internal equilibrium of glucose in the fluids and tissues http://purl.obolibrary.org/obo/OAE_0000588 hematopoietic system AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event an adverse event which occurs in a hematopoietic system, which is any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells http://purl.obolibrary.org/obo/OAE_0000593 joint inflammation AE http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE An joint disorder AE that has an outcome of joint inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the joints http://purl.obolibrary.org/obo/OAE_0000596 arthritis AE http://purl.obolibrary.org/obo/OAE_0000593 joint inflammation AE A joint inflammation AE that has an outcome of arthritis, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures http://purl.obolibrary.org/obo/OAE_0000597 dysphagia AE http://purl.obolibrary.org/obo/OAE_0000580 behavioral and neurological AE a digestive system AE which has an outcome of dysphagia, which is a behavior and neurological AE that has an outcome of difficulty in swallowing food or liquid http://purl.obolibrary.org/obo/OAE_0000600 nausea AE http://purl.obolibrary.org/obo/OAE_0000554 abnormal digestion AE an abnormal digestion AE which has an outcome of nausea, a gastric discomfort associated with the inclination to vomit http://purl.obolibrary.org/obo/OAE_0000603 abnormal defecation AE http://purl.obolibrary.org/obo/OAE_0000439 digestive system AE a digestive system AE that has an outcome of abnormal defecation, an anomaly in the production and excretion of feces http://purl.obolibrary.org/obo/OAE_0000607 tinnitus AE http://purl.obolibrary.org/obo/OAE_0002129 hearing disorder AE an hearing disorder AE that shows a persistent sensation of buzzing, ringing, clicking, or other noises in the ear http://purl.obolibrary.org/obo/OAE_0000613 myositis AE http://purl.obolibrary.org/obo/OAE_0000614 muscle inflammation AE a muscle inflammation AE which has an outcome of myositis, which is an inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle http://purl.obolibrary.org/obo/OAE_0000614 muscle inflammation AE http://purl.obolibrary.org/obo/OAE_0000435 muscle AE a muscle adverse event which has an outcome of muscle inflammation, which is a local accumulation of fluid, plasma proteins, and leukocytes in muscle http://purl.obolibrary.org/obo/OAE_0000617 hypoxia AE http://purl.obolibrary.org/obo/OAE_0000555 homeostasis AE a homeostasis AE which has an outcome of hypoxia, which is a reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases http://purl.obolibrary.org/obo/OAE_0000618 sepsis AE http://purl.obolibrary.org/obo/OAE_0000363 infection AE an infectious adverse event which has an outcome of the presence of various pathogenic organisms, or their toxins, in the blood or tissues that results in the infections in blood stream. http://purl.obolibrary.org/obo/OAE_0000622 urinary system AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event an adverse event that has an outcome of urinary system AE is a functional anomaly of any of the organs involved in the production or excretion of urine http://purl.obolibrary.org/obo/OAE_0000624 abnormal body temperature AE http://purl.obolibrary.org/obo/OAE_0000555 homeostasis AE a homeostasis AE whic has an outcome of abnomal body temperature, which is a deviation in the level of heat natural to a living being http://purl.obolibrary.org/obo/OAE_0000632 death AE http://purl.obolibrary.org/obo/OAE_0000631 serious adverse event a serious adverse event that has an outcome of death. http://purl.obolibrary.org/obo/OAE_0000651 reproductive system AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event reproductive system AE is an AE that occurs in the reproductive system. http://purl.obolibrary.org/obo/OAE_0000656 aspartate aminotransferase level increased AE http://purl.obolibrary.org/obo/OAE_0001697 aspartate aminotransferase level abnormal AE an aspartate aminotransferase level abnormal AE that has an outcome of an increased amount of AST, an enzyme normally present in body tissues especially of the heart and liver http://purl.obolibrary.org/obo/OAE_0000666 aspiration AE http://purl.obolibrary.org/obo/OAE_0000378 respiratory system AE a respiratory system AE that has an outcome of the drawing of a foreign substance into the respiratory tract during inhalation http://purl.obolibrary.org/obo/OAE_0000669 facial pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has an outcome of facial pain http://purl.obolibrary.org/obo/OAE_0000674 atelectasis AE http://purl.obolibrary.org/obo/OAE_0000434 lung AE a lung disorder AE that has an outcome of collapse in part of or all of a lung http://purl.obolibrary.org/obo/OAE_0000676 joint range of motion decreased AE http://purl.obolibrary.org/obo/OAE_0000332 mobility decreased AE joint range of motion decreased AE is a mobility decreased AE that results in limited or decreased range of joint motion http://purl.obolibrary.org/obo/OAE_0000677 laryngospasm AE http://purl.obolibrary.org/obo/OAE_0000521 muscle spasm AE a muscle spasm AE which has an outcome of laryngospasm, which is an uncontrolled/involuntary muscular contraction (spasm) of the laryngeal cords. The condition typically lasts less than 60 seconds, and causes a partial blocking of breathing in, while breathing out remains easier. It may be triggered when the vocal cords or the area of the trachea below the cords detects the entry of water, mucus, blood, or other substance. It is characterized by stridor and or retractions. http://purl.obolibrary.org/obo/OAE_0000683 hypermagnesemia AE http://purl.obolibrary.org/obo/OAE_0001581 blood magnesium abnormal AE a blood magnesium abnormal AE that has an outcome of an abnormally high concentration of magnesium in the blood plasma, and may cause nausea, weakness and tremors. http://purl.obolibrary.org/obo/OAE_0000690 stridor AE http://purl.obolibrary.org/obo/OAE_0000053 wheezing AE a wheezing AE which has an outcome of stridor, a high pitched wheezing sound resulting from turbulent air flow in the upper airway. It is primarily inspiratory. It can be indicative of serious airway obstruction from severe conditions such as epiglottitis, a foreign body lodged in the airway, or a laryngeal tumor. http://purl.obolibrary.org/obo/OAE_0000718 blood alkaline phosphatase level abnormal AE http://purl.obolibrary.org/obo/OAE_0001694 liver related investigation result abnormal AE a liver related investigation result abnormal AE that has an outcome of an abnormal level of alkaline phosphatase in the blood http://purl.obolibrary.org/obo/OAE_0000720 blood alkaline phosphatase increased AE http://purl.obolibrary.org/obo/OAE_0000718 blood alkaline phosphatase level abnormal AE a blood alkaline phosphatase abnormal AE that has an outcome of elevated levels of alkaline phosphatase, an enzyme responsible for removing phosphate groups. a liver/biliary system AE that has an outcome of an increased amount of ALP, an isoenzyme that removes phosphate groups commonly found in the bile ducts but also found in the bone http://purl.obolibrary.org/obo/OAE_0000723 blood bilirubin level abnormal AE http://purl.obolibrary.org/obo/OAE_0001694 liver related investigation result abnormal AE a liver related investigation result abnormal AE that has an outcome of an abnormal amount of bilirubin in the blood http://purl.obolibrary.org/obo/OAE_0000724 blood bilirubin level increased AE http://purl.obolibrary.org/obo/OAE_0000723 blood bilirubin level abnormal AE a blood bilirubin level abnormal AE with an outcome of a increased amount of bilirubin, or a yellow breakdown product (broken down hemoglobin) of normal heme catabolism, in the blood http://purl.obolibrary.org/obo/OAE_0000725 blood calcium decreased http://purl.obolibrary.org/obo/PATO_0001018 physical quality a physical quality that has a decreased amount of calcium in the bloodstream http://purl.obolibrary.org/obo/OAE_0000727 blood cholesterol increased AE http://purl.obolibrary.org/obo/OAE_0001591 blood cholesterol abnormal AE a blood cholesterol abnormal AE with the result of an increase in cholesterol level in the blood http://purl.obolibrary.org/obo/OAE_0000738 blood magnesium decreased http://purl.obolibrary.org/obo/PATO_0001018 physical quality A physical quality that has an decreased level of magnesium, a mineral involved in nerve signaling and bone health. Deficiency can cause spasms, and muscular cramps. http://purl.obolibrary.org/obo/OAE_0000741 blood potassium decreased http://purl.obolibrary.org/obo/PATO_0001018 physical quality a physical quality where the blood potassium level is decreased. http://purl.obolibrary.org/obo/OAE_0000744 blood sodium decreased http://purl.obolibrary.org/obo/PATO_0001018 physical quality A physical quality that has an decreased level of sodium concentration in the blood http://purl.obolibrary.org/obo/OAE_0000753 bone marrow disorder AE http://purl.obolibrary.org/obo/OAE_0000588 hematopoietic system AE a hematopoietic system AE that has an outcome of disease in the bone marrow, the spongy tissue inside of some bones that contain stem cells that can develop into red blood cells, white blood cells or platelets http://purl.obolibrary.org/obo/OAE_0000765 breast infection AE http://purl.obolibrary.org/obo/OAE_0000363 infection AE an infection AE that results in the breast becoming infected http://purl.obolibrary.org/obo/OAE_0000766 breast pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that results in pain in the breast http://purl.obolibrary.org/obo/OAE_0000770 bronchospasm AE http://purl.obolibrary.org/obo/OAE_0000434 lung AE a lung disorder AE that has an outcome of a sudden constriction of the muscles in the walls of the bronchioles http://purl.obolibrary.org/obo/OAE_0000783 cardiac ventricular disorder AE http://purl.obolibrary.org/obo/OAE_0000084 cardiac disorder AE a cardiac disorder AE that has an outcome of a disorder involving the ventricle(s) in the heart http://purl.obolibrary.org/obo/OAE_0000785 cardiomyopathy AE http://purl.obolibrary.org/obo/OAE_0000084 cardiac disorder AE a cardiovascular disorder AE that has an outcome of deterioration of the function of the myocardium, usually leads to heart failure http://purl.obolibrary.org/obo/OAE_0000789 cataract AE http://purl.obolibrary.org/obo/OAE_0000443 eye AE a eye disorder AE that results in cloudiness that develops in the eye http://purl.obolibrary.org/obo/OAE_0000791 catheter related infection AE http://purl.obolibrary.org/obo/OAE_0000363 infection AE an infection AE that has an outcome of an infection (e.g., bacterial colonisation) at the catheter site http://purl.obolibrary.org/obo/OAE_0000805 cheilitis AE http://purl.obolibrary.org/obo/OAE_0000439 digestive system AE an inflammation AE that occurs in the lip http://purl.obolibrary.org/obo/OAE_0000820 chylothorax AE http://purl.obolibrary.org/obo/OAE_0000434 lung AE a lung disorder AE that has an outcome of lymphatic fluid accumulating in the pleural cavity, the space between two pleura of the lungs http://purl.obolibrary.org/obo/OAE_0000825 colitis AE http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE an inflammation AE that occurs at the large intestine http://purl.obolibrary.org/obo/OAE_0000839 connective tissue disorder AE http://purl.obolibrary.org/obo/OAE_0000027 musculoskeletal or connective tissue AE an adverse event that has an outcome of disease in the biological tissue that supports, binds together and protects organs http://purl.obolibrary.org/obo/OAE_0000854 cytokine release syndrome AE http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE an inflammation AE that has an outcome of release of cytokines by T cells that causes inflammation http://purl.obolibrary.org/obo/OAE_0000862 delirium AE http://purl.obolibrary.org/obo/OAE_0001797 psychiatric disorder AE a psychiatric disorder AE that results in a decline in level of cognitive function http://purl.obolibrary.org/obo/OAE_0000863 dental caries AE http://purl.obolibrary.org/obo/OAE_0001458 tooth disorder AE a tooth disorder AE that has an outcome of bacterial infection that causes demineralization and destruction of the hard tissues, resulting in dental cavities http://purl.obolibrary.org/obo/OAE_0000864 depressed level of consciousness AE http://purl.obolibrary.org/obo/OAE_0000582 sensory capability AE a sensory capability AE that results in a lower level of arousal than normal http://purl.obolibrary.org/obo/OAE_0000871 device related infection AE http://purl.obolibrary.org/obo/OAE_0002617 device AE an injury and procedural complication AE that results in an infection related to medical device http://purl.obolibrary.org/obo/OAE_0000882 disseminated intravascular coagulation AE http://purl.obolibrary.org/obo/OAE_0000588 hematopoietic system AE a hematopoietic system AE with an outcome of a serious disorder in which proteins that control blood clotting become abnormally active http://purl.obolibrary.org/obo/OAE_0000894 dry skin AE http://purl.obolibrary.org/obo/OAE_0000543 skin AE a skin AE that is characterized by epidermis that lacks moisture, has an outcome of fine lines, scaling and itching http://purl.obolibrary.org/obo/OAE_0000898 dysarthria AE http://purl.obolibrary.org/obo/OAE_0000426 speech disorder AE a speech disorder that results in a motor speech disorder http://purl.obolibrary.org/obo/OAE_0000908 ejection fraction decreased AE http://purl.obolibrary.org/obo/OAE_0001119 left ventricular dysfunction AE a left ventricular dysfunction AE that has an outcome of decreased percentage of blood leaving the heart each time it contracts http://purl.obolibrary.org/obo/OAE_0000909 electrocardiogram result abnormal AE http://purl.obolibrary.org/obo/OAE_0002612 cardiac function test abnormal AE a cardiac function test abnormal AE that has an outcome of abnormal electrical activity in the heart http://purl.obolibrary.org/obo/OAE_0000911 electrocardiogram qt prolonged AE http://purl.obolibrary.org/obo/OAE_0000909 electrocardiogram result abnormal AE an electrocardiogram result abnormal AE that has an outcome of a prolonged time between the start of the Q wave and the end of the T wave in the heart's electrical cycle; a biomarker for ventricular tachyarrhythmias http://purl.obolibrary.org/obo/OAE_0000917 enterocolitis AE http://purl.obolibrary.org/obo/OAE_0000439 digestive system AE a digestive system AE that has an outcome of disease in the digestive tract caused by infection http://purl.obolibrary.org/obo/OAE_0000933 extraocular muscle paresis AE http://purl.obolibrary.org/obo/OAE_0000205 paresis AE a paresis AE that results in a partial loss of voluntary movement in their extraocular muscles http://purl.obolibrary.org/obo/OAE_0000939 fall AE http://purl.obolibrary.org/obo/OAE_0000580 behavioral and neurological AE a behavior and neurological AE that has an outcome of patient falling http://purl.obolibrary.org/obo/OAE_0000954 forced expiratory volume decreased AE http://purl.obolibrary.org/obo/OAE_0000378 respiratory system AE a respiratory system AE that has an outcome of a decreased volume of air expired from the lungs http://purl.obolibrary.org/obo/OAE_0000956 fracture AE http://purl.obolibrary.org/obo/OAE_0000518 bone AE a bone disorder AE that has an outcome of complete or incomplete break in a bone resulting from the application of excessive force http://purl.obolibrary.org/obo/OAE_0000959 gallbladder enlargement AE http://purl.obolibrary.org/obo/OAE_0000439 digestive system AE a digestive system AE that has an outcome of an abnormal enlargement in the size of the gallbladder http://purl.obolibrary.org/obo/OAE_0000960 gallbladder perforation AE http://purl.obolibrary.org/obo/OAE_0000439 digestive system AE a digestive system AE that has an outcome of an abnormal hole in the patient's gallbladder http://purl.obolibrary.org/obo/OAE_0000963 gamma-glutamyltransferase level abnormal AE http://purl.obolibrary.org/obo/OAE_0001694 liver related investigation result abnormal AE a liver related investigation result abnormal AE that has an outcome of an abnormal level of gamma-glutamyltransferase (GGT); GGT is involved in the transfer of amino acids across the cellular membrane http://purl.obolibrary.org/obo/OAE_0000968 gastritis AE http://purl.obolibrary.org/obo/OAE_0001845 gastric disorder AE a gastric disorder AE that has an outcome of inflammation in the lining of the stomach http://purl.obolibrary.org/obo/OAE_0000979 gastrointestinal perforation AE http://purl.obolibrary.org/obo/OAE_0000455 gastrointestinal disorder AE a gastrointestinal disorder AE that results in a hole in the wall of the esophagus, stomch, small intestine, large bowel, rectum or gallbladder http://purl.obolibrary.org/obo/OAE_0001021 hair growth abnormal AE http://purl.obolibrary.org/obo/OAE_0000200 hair AE a hair AE that has an outcome of abnormal growth of facial or body hair http://purl.obolibrary.org/obo/OAE_0001026 hepatic failure AE http://purl.obolibrary.org/obo/OAE_0001135 liver AE a liver/biliary system AE that has an outcome of the inability of the liver to perform its normal synthetic and metabolic function http://purl.obolibrary.org/obo/OAE_0001030 hepatic necrosis AE http://purl.obolibrary.org/obo/OAE_0001135 liver AE a liver/biliary system AE that has an outcome of death of hepatic parenchyma which may be single cell, or multicell in piecemeal, focal, periacinar, midzonal, periportal or paracentral locations http://purl.obolibrary.org/obo/OAE_0001034 hepatitis viral AE http://purl.obolibrary.org/obo/OAE_0000210 hepatitis AE a hepatitis AE that has an outcome of liver inflammation due to a hepatitis viral infection http://purl.obolibrary.org/obo/OAE_0001045 hyperhidrosis AE http://purl.obolibrary.org/obo/OAE_0000401 sweating AE a skin AE that results in excess perspiration http://purl.obolibrary.org/obo/OAE_0001063 hypothyroidism AE http://purl.obolibrary.org/obo/OAE_0000202 endocrine system AE an endocrine system AE with the outcome of the thyroid gland does not make enough thyroid hormone http://purl.obolibrary.org/obo/OAE_0001067 ileal perforation AE http://purl.obolibrary.org/obo/OAE_0000439 digestive system AE a digestive system AE that has an outcome of holes in the ileum of the small intestine http://purl.obolibrary.org/obo/OAE_0001081 infusion related reaction AE http://purl.obolibrary.org/obo/OAE_0000476 immune system AE a immune system AE that results in an allergic reaction to foreign protein, but can also be caused by cytokine release. http://purl.obolibrary.org/obo/OAE_0001082 infusion site extravasation AE http://purl.obolibrary.org/obo/OAE_0000546 abnormal fluid regulation AE an extravasation AE that has an outcome of leaking of pharmacologic or biological substance from infusion site into surrounding tissue. Symptoms include induration, erythema, swelling, burning sensation and pain http://purl.obolibrary.org/obo/OAE_0001119 left ventricular dysfunction AE http://purl.obolibrary.org/obo/OAE_0000783 cardiac ventricular disorder AE a cardiac ventricular disorder AE that has an outcome of inability of the left ventricle to pump blood, may lead to heart failure http://purl.obolibrary.org/obo/OAE_0001128 leukoencephalopathy AE http://purl.obolibrary.org/obo/OAE_0000494 encephalopathy AE an encephalopathy AE that has an outcome of brain white matter disease http://purl.obolibrary.org/obo/OAE_0001129 leukopenia AE http://purl.obolibrary.org/obo/OAE_0000588 hematopoietic system AE a hematopoietic system AE that has an outcome of a lower than normal number of leukocytes, or nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue http://purl.obolibrary.org/obo/OAE_0001130 libido disorder AE http://purl.obolibrary.org/obo/OAE_0001797 psychiatric disorder AE a psychiatric disorder AE that results in a disorder in the patient's desire for sexual interaction http://purl.obolibrary.org/obo/OAE_0001144 lung infection AE http://purl.obolibrary.org/obo/OAE_0000363 infection AE an infection AE that has an outcome of infection in the lungs http://purl.obolibrary.org/obo/OAE_0001149 lymphocyte count decreased AE http://purl.obolibrary.org/obo/OAE_0001676 lymphocyte count abnormal AE a lymphocyte count abnormal AE that has an outcome of a decreased amount of lymphocytes in the blood, a type of white blood cell in the immune system http://purl.obolibrary.org/obo/OAE_0001167 memory impairment AE http://purl.obolibrary.org/obo/OAE_0000580 behavioral and neurological AE Behavior and Neurological AE that results in the loss of memory http://purl.obolibrary.org/obo/OAE_0001170 menorrhagia AE http://purl.obolibrary.org/obo/OAE_0000082 female reproductive system AE Female Reproductive System AE that results in abnormally heavy and prolonged menstrual period http://purl.obolibrary.org/obo/OAE_0001172 metabolic disorder AE http://purl.obolibrary.org/obo/OAE_0000069 metabolism, endocrine or exocrine system AE a metabolism, endocrine, and exocrine system AE that has an outcome of abnormal chemical reactions in the body that disrupts a metabolic process http://purl.obolibrary.org/obo/OAE_0001193 muscle enzyme level increased AE http://purl.obolibrary.org/obo/OAE_0001683 muscle enzyme level abnormal AE a muscle enzyme level abnormal AE that results in an increased level of muscle enzyme http://purl.obolibrary.org/obo/OAE_0001198 myelodysplastic syndrome AE http://purl.obolibrary.org/obo/OAE_0000588 hematopoietic system AE a hematopoietic system AE that has an outcome of ineffective production of the myeloid class of blood cells http://purl.obolibrary.org/obo/OAE_0001201 myocarditis AE http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE an inflammation AE that has an outcome of inflammation of the heart muscle http://purl.obolibrary.org/obo/OAE_0001203 nail infection AE http://purl.obolibrary.org/obo/OAE_0000201 nail AE a nail AE around the nail area, tends to be fungal http://purl.obolibrary.org/obo/OAE_0001217 neutropenia AE http://purl.obolibrary.org/obo/OAE_0001129 leukopenia AE a neutropenia AE that compromises the immune system where the number of neutrophil granulocytes, a type of white blood cell, is abnormally low. A neutropenia makes body vulnerable to bacterial and fungal infections. http://purl.obolibrary.org/obo/OAE_0001221 neutrophil count abnormal AE http://purl.obolibrary.org/obo/OAE_0001666 white blood cell profile abnormal AE a white blood cell profile abnormal AE that results in an abnormal number of neutrophil granulocytes, a type of white blood cell (outside the normal range of ~1700 per microliter) http://purl.obolibrary.org/obo/OAE_0001244 oral cavity fistula AE http://purl.obolibrary.org/obo/OAE_0000439 digestive system AE a digestive system AE that has an outcome of fistula, or an abnormal connection between two epithelium-lined organs or vessels, located in the oral cavity http://purl.obolibrary.org/obo/OAE_0001249 oral pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE located in the oral cavity, pertaining to the mouth http://purl.obolibrary.org/obo/OAE_0001269 pain of skin AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE located in the skin http://purl.obolibrary.org/obo/OAE_0001281 pericardial effusion AE http://purl.obolibrary.org/obo/OAE_0000084 cardiac disorder AE a cardiac disorder AE that has an outcome of abnormal accumulation of fluid in the pericardial cavity http://purl.obolibrary.org/obo/OAE_0001282 perineal pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that results in soreness around the vaginal opening after giving birth http://purl.obolibrary.org/obo/OAE_0001286 peripheral motor neuropathy AE http://purl.obolibrary.org/obo/OAE_0000168 motor neuropathy AE a motor neuropathy AE that results in damage to the nerves outside of the brain and spinal cord http://purl.obolibrary.org/obo/OAE_0001288 peripheral sensory neuropathy AE http://purl.obolibrary.org/obo/OAE_0000162 sensory neuropathy AE a sensory neuropathy AE that has an outcome of damaged nerves outside the brain and spinal cord http://purl.obolibrary.org/obo/OAE_0001298 pleural effusion AE http://purl.obolibrary.org/obo/OAE_0000378 respiratory system AE a respiratory system AE that has an outcome of fluid buildup between the layers of tissue that line the lungs and chest cavity http://purl.obolibrary.org/obo/OAE_0001301 pleuritic pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE induced by inflammation in the lungs that is characterized by sharp or stabbing pain in the chest http://purl.obolibrary.org/obo/OAE_0001308 pneumothorax AE http://purl.obolibrary.org/obo/OAE_0000434 lung AE a lung disorder AE that has an outcome of a collapsed lung due to collection of air in the space around the lungs. http://purl.obolibrary.org/obo/OAE_0001311 portal hypertension AE http://purl.obolibrary.org/obo/OAE_0000403 hypertension AE a hypertension AE located in the heptatic portal system caused by obstruction or occlusion that produces splenomegaly and ascites in its later stages http://purl.obolibrary.org/obo/OAE_0001319 presyncope AE http://purl.obolibrary.org/obo/OAE_0000582 sensory capability AE a sensory capability AE that has an outcome of a near-fainting episode which may include lightheadedness, dizziness, severe weakness, blurred vision, which may precede syncopal episode http://purl.obolibrary.org/obo/OAE_0001326 productive cough AE http://purl.obolibrary.org/obo/OAE_0000398 cough AE a cough AE that has an outcome of secretions that could be mucous or blood http://purl.obolibrary.org/obo/OAE_0001341 pulmonary fibrosis AE http://purl.obolibrary.org/obo/OAE_0000434 lung AE a lung disorder AE wih the outcome of damaged or scarred lung tissue. Thickened tissue impairs lung function http://purl.obolibrary.org/obo/OAE_0001343 pulmonary hypertension AE http://purl.obolibrary.org/obo/OAE_0000434 lung AE a lung disorder AE that has an outcome of abnormally high blood pressure in the arteris of the lungs http://purl.obolibrary.org/obo/OAE_0001354 radiation skin injury AE http://purl.obolibrary.org/obo/OAE_0000543 skin AE a skin AE that has an outcome of injury to the skin and underlying tissues from exposure to a large external dose of radiation http://purl.obolibrary.org/obo/OAE_0001359 recall phenomenon AE http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE an inflammation AE that has an outcome of an inflammatory reaction limited to a previously X-irradiated field when the patient is treated months/years later with certain drugs http://purl.obolibrary.org/obo/OAE_0001377 reversible posterior leukoencephalopathy syndrome AE http://purl.obolibrary.org/obo/OAE_0000494 encephalopathy AE an encephalopathy AE that is characterized by headache, confusion, seizures and visual loss, tends to resolve over time http://purl.obolibrary.org/obo/OAE_0001392 sinus disorder AE http://purl.obolibrary.org/obo/OAE_0000378 respiratory system AE a respiratory system AE that has an outcome of disease in the air-filled spaces that surround the nasal cavity, above the eyes and behind the ethmoids http://purl.obolibrary.org/obo/OAE_0001393 sinus tachycardia AE http://purl.obolibrary.org/obo/OAE_0000355 tachycardia AE a tachycardia AE that has an outcome of elevated impulses originating from the sinoatrial node, greater than 100 bpm http://purl.obolibrary.org/obo/OAE_0001397 skin hyperpigmentation AE http://purl.obolibrary.org/obo/OAE_0000423 skin discoloration AE a skin AE that has an outcome of darkening in an area of skin or nails caused by increased melanin http://purl.obolibrary.org/obo/OAE_0001398 skin infection AE http://purl.obolibrary.org/obo/OAE_0000543 skin AE a skin AE that has an outcome of infection. Can be bacterial, fungal, parasitic or viral http://purl.obolibrary.org/obo/OAE_0001403 sleep disorder AE http://purl.obolibrary.org/obo/OAE_0000580 behavioral and neurological AE a behavior and neurological AE that results in irregular sleep patterns http://purl.obolibrary.org/obo/OAE_0001405 small intestinal obstruction AE http://purl.obolibrary.org/obo/OAE_0000455 gastrointestinal disorder AE a gastrointestinal disorder AE that has an outcome of a blockage that keeps substance from passing through the small intestine, may be caused by fibrous bands of tissue in the abdomen, inflamed/infected pouches in the intestine, or hernias and tumors http://purl.obolibrary.org/obo/OAE_0001407 small intestinal stenosis AE http://purl.obolibrary.org/obo/OAE_0000455 gastrointestinal disorder AE a gastrointestinal disorder AE in which the blood vessels in the small intestine narrow http://purl.obolibrary.org/obo/OAE_0001409 small intestine ulcer AE http://purl.obolibrary.org/obo/OAE_0000455 gastrointestinal disorder AE a gastrointestinal disorder AE that results in an ulcer in the patient's small intestine http://purl.obolibrary.org/obo/OAE_0001410 soft tissue infection AE http://purl.obolibrary.org/obo/OAE_0000839 connective tissue disorder AE a connective tissue disorder AE that occurs in the non-skeletal tissue, usually subcutaneous and muscle tissue http://purl.obolibrary.org/obo/OAE_0001425 stevens-johnson syndrome AE http://purl.obolibrary.org/obo/OAE_0000543 skin AE a skin adverse event that is characterized by cell death causing the epidermis to separate from the dermis http://purl.obolibrary.org/obo/OAE_0001431 sudden death AE http://purl.obolibrary.org/obo/OAE_0000632 death AE a death AE that has an outcome of unexpected death, 1 to 24 hours after the onset of symptoms http://purl.obolibrary.org/obo/OAE_0001432 suicidal ideation AE http://purl.obolibrary.org/obo/OAE_0001797 psychiatric disorder AE a psychiatric disorder AE that results in thoughts about suicide http://purl.obolibrary.org/obo/OAE_0001433 suicide attempt AE http://purl.obolibrary.org/obo/OAE_0001797 psychiatric disorder AE a psychiatric disorder AE that results in attempted suicide http://purl.obolibrary.org/obo/OAE_0001437 supraventricular tachycardia AE http://purl.obolibrary.org/obo/OAE_0000355 tachycardia AE a tachycardia AE that has an outcome of rapid heart rhythm originating at or above the atrioventricular node http://purl.obolibrary.org/obo/OAE_0001449 thrombophlebitis AE http://purl.obolibrary.org/obo/OAE_0000194 phlebitis AE a phlebitis AE located in the vein, caused by a blood clot http://purl.obolibrary.org/obo/OAE_0001458 tooth disorder AE http://purl.obolibrary.org/obo/OAE_0000518 bone AE a bone disorder AE that has an outcome of disease in the teeth http://purl.obolibrary.org/obo/OAE_0001464 tracheitis AE http://purl.obolibrary.org/obo/OAE_0000378 respiratory system AE a respiratory system AE that results in the trachea being infected by a bacteria http://purl.obolibrary.org/obo/OAE_0001473 troponin level increased AE http://purl.obolibrary.org/obo/OAE_0001682 troponin level abnormal AE a troponin level abnormal AE that has an outcome of an increased amount of troponin, a protein released when the heart muscle is damaged http://purl.obolibrary.org/obo/OAE_0001489 urinary retention AE http://purl.obolibrary.org/obo/OAE_0000622 urinary system AE Urinary system AE that results in an inability to urinate http://purl.obolibrary.org/obo/OAE_0001493 urine output decreased AE http://purl.obolibrary.org/obo/OAE_0000495 urine abnormality AE a urine abnormality AE that has an outcome of decreased urine output, less than 500 milliliters of urine in 24 hours http://purl.obolibrary.org/obo/OAE_0001499 vaginal infection AE http://purl.obolibrary.org/obo/OAE_0000363 infection AE an infection AE that results in infection of the vagina http://purl.obolibrary.org/obo/OAE_0001504 venous injury AE http://purl.obolibrary.org/obo/OAE_0000184 dementia AE a vascular disorder AE that results in an injury to the vein(s) http://purl.obolibrary.org/obo/OAE_0001516 wolff-parkinson-white syndrome AE http://purl.obolibrary.org/obo/OAE_0000316 conduction system disorder AE a conduction system disorder AE that results in an abnormal accessory electrical conduction pathway between the atria and ventricles http://purl.obolibrary.org/obo/OAE_0001517 wound complication AE http://purl.obolibrary.org/obo/OAE_0002575 wound AE a wound AE that has an outcome of complication to the wound http://purl.obolibrary.org/obo/OAE_0001518 wound dehiscence AE http://purl.obolibrary.org/obo/OAE_0002575 wound AE a wound AE that has an outcome of a wound breaking open along the surgical sutures http://purl.obolibrary.org/obo/OAE_0001527 multi-organ failure AE http://purl.obolibrary.org/obo/OAE_0000063 systematic AE A systematic adverse event that has an outcome of failure in mulitple organs http://purl.obolibrary.org/obo/OAE_0001529 osteoporosis AE http://purl.obolibrary.org/obo/OAE_0000518 bone AE A bone disorder AE that has an outcome of the weakening or brittle bone http://purl.obolibrary.org/obo/OAE_0001554 restlessness AE http://purl.obolibrary.org/obo/OAE_0001797 psychiatric disorder AE a psychiatric disorder AE that shows restlessness http://purl.obolibrary.org/obo/OAE_0001570 cardiovascular investigation result abnormal AE http://purl.obolibrary.org/obo/OAE_0000628 investigation result abnormal AE an investigation result abnormal AE that involves an abnormal result of an investigation involving the cardiovascular system http://purl.obolibrary.org/obo/OAE_0001573 electrolyte lab test abnormal AE http://purl.obolibrary.org/obo/OAE_0000628 investigation result abnormal AE an investigation result abnormal AE that involves an abnormal electrolyte value http://purl.obolibrary.org/obo/OAE_0001574 blood phosphorus abnormal AE http://purl.obolibrary.org/obo/OAE_0000553 electrolyte blood test abnormal AE an electrolyte lab test abnormal AE that shows an abnormal blood phosphorus level http://purl.obolibrary.org/obo/OAE_0001577 blood potassium abnormal AE http://purl.obolibrary.org/obo/OAE_0000553 electrolyte blood test abnormal AE an electrolyte lab test abnormal AE that results in an abnormal level of potassium in the blood http://purl.obolibrary.org/obo/OAE_0001579 blood sodium abnormal AE http://purl.obolibrary.org/obo/OAE_0000553 electrolyte blood test abnormal AE an electrolyte lab test abnormal AE that results in an abnormal level of sodium in the blood http://purl.obolibrary.org/obo/OAE_0001580 blood sodium increased http://purl.obolibrary.org/obo/PATO_0001018 physical quality A physical quality that has an increased level of sodium in the blood http://purl.obolibrary.org/obo/OAE_0001581 blood magnesium abnormal AE http://purl.obolibrary.org/obo/OAE_0000553 electrolyte blood test abnormal AE an electrolyte lab test abnormal AE that results in an abnormal level of magnesium in the blood http://purl.obolibrary.org/obo/OAE_0001585 blood calcium abnormal AE http://purl.obolibrary.org/obo/OAE_0000553 electrolyte blood test abnormal AE an electrolyte lab test abnormal AE that results in an abnormal level of calcium in the blood http://purl.obolibrary.org/obo/OAE_0001586 blood calcium increased http://purl.obolibrary.org/obo/PATO_0001018 physical quality A physical quality that has an increased level of calcium in the blood http://purl.obolibrary.org/obo/OAE_0001588 blood creatinine level abnormal AE http://purl.obolibrary.org/obo/OAE_0001587 urinary system investigation result abnormal AE a urinary system investigation result abnormal AE that is characterized by an abnormal level of creatinine in the blood http://purl.obolibrary.org/obo/OAE_0001590 lipid analysis result abnormal AE http://purl.obolibrary.org/obo/OAE_0000628 investigation result abnormal AE an investigation result abnormal AE that involves an abnormal result of a lipid analyses http://purl.obolibrary.org/obo/OAE_0001591 blood cholesterol abnormal AE http://purl.obolibrary.org/obo/OAE_0001590 lipid analysis result abnormal AE a lipid analysis result abnormal AE that results in an abnormal blood cholesterol level http://purl.obolibrary.org/obo/OAE_0001602 immunology and allergy investigation result abnormal AE http://purl.obolibrary.org/obo/OAE_0000628 investigation result abnormal AE an investigation result abnormal AE that involves an abnormal result for an immunology and allergy investigation http://purl.obolibrary.org/obo/OAE_0001644 physical examination result abnormal AE http://purl.obolibrary.org/obo/OAE_0000628 investigation result abnormal AE an investigation result abnormal AE resulting from an abnormal physical examination finding http://purl.obolibrary.org/obo/OAE_0001646 respiratory and pulmonary investigation result abnormal AE http://purl.obolibrary.org/obo/OAE_0000628 investigation result abnormal AE an investigation result abnormal AE that involves an abnormal respiratory and pulmonary investigation http://purl.obolibrary.org/obo/OAE_0001647 endocrine investigation result abnormal AE http://purl.obolibrary.org/obo/OAE_0000628 investigation result abnormal AE an investigation result abnormal AE that involves an abnormal result of an endocrine investigation http://purl.obolibrary.org/obo/OAE_0001662 enzyme investigation result abnormal AE http://purl.obolibrary.org/obo/OAE_0000628 investigation result abnormal AE an investigation result abnormal AE that is characterized by an abnormal result of an enzyme investigation http://purl.obolibrary.org/obo/OAE_0001665 red blood cell profile abnormal AE http://purl.obolibrary.org/obo/OAE_0001664 hematology investigation result abnormal AE a hematology investigation result abnormal AE that results in an abnormal red blood cell profile http://purl.obolibrary.org/obo/OAE_0001666 white blood cell profile abnormal AE http://purl.obolibrary.org/obo/OAE_0001664 hematology investigation result abnormal AE a hematology investigation result abnormal AE that is characterized by an abnormal white blood cell profile http://purl.obolibrary.org/obo/OAE_0001673 leukocyte cell number abnormal AE http://purl.obolibrary.org/obo/OAE_0001666 white blood cell profile abnormal AE a white blood cell profile abnormal AE that is characterized by an abnormal leukocyte cell number http://purl.obolibrary.org/obo/OAE_0001676 lymphocyte count abnormal AE http://purl.obolibrary.org/obo/OAE_0001666 white blood cell profile abnormal AE a white blood cell profile abnormal AE that is characterized by an abnormal lymphocyte cell number http://purl.obolibrary.org/obo/OAE_0001682 troponin level abnormal AE http://purl.obolibrary.org/obo/OAE_0001662 enzyme investigation result abnormal AE an enzyme investigation result abnormal AE that is characterized by an abnormal troponin level http://purl.obolibrary.org/obo/OAE_0001683 muscle enzyme level abnormal AE http://purl.obolibrary.org/obo/OAE_0001662 enzyme investigation result abnormal AE an enzyme investigation result abnormal AE that is characterized by an abnormal muscle enzyme level http://purl.obolibrary.org/obo/OAE_0001688 gastrointestinal investigation result abnormal AE http://purl.obolibrary.org/obo/OAE_0000628 investigation result abnormal AE an investigation result abnormal AE that is characterized by an abnormal result of a gastrointestinal investigation http://purl.obolibrary.org/obo/OAE_0001689 blood amylase level abnormal AE http://purl.obolibrary.org/obo/OAE_0001688 gastrointestinal investigation result abnormal AE a gastrointestinal investigation result abnormal AE that is characterized by an abnormal blood amylase level http://purl.obolibrary.org/obo/OAE_0001694 liver related investigation result abnormal AE http://purl.obolibrary.org/obo/OAE_0000628 investigation result abnormal AE an investigation result abnormal AE that is characterized by an abnormal liver related investigation result http://purl.obolibrary.org/obo/OAE_0001697 aspartate aminotransferase level abnormal AE http://purl.obolibrary.org/obo/OAE_0001694 liver related investigation result abnormal AE a liver related investigation result abnormal AE that is characterized by an abnormal aspartate aminotransferase level http://purl.obolibrary.org/obo/OAE_0001715 hemoglobin level increased AE http://purl.obolibrary.org/obo/OAE_0001009 hemoglobin level abnormal AE a hemoglobin level abnormal AE that is characterized by an increased hemoglobin level http://purl.obolibrary.org/obo/OAE_0001731 platelet count abnormal AE http://purl.obolibrary.org/obo/OAE_0001664 hematology investigation result abnormal AE a hematology investigation result abnormal AE that is characterized by an abnormal platelet count http://purl.obolibrary.org/obo/OAE_0001741 right ventricular dysfunction AE http://purl.obolibrary.org/obo/OAE_0000783 cardiac ventricular disorder AE a cardiac ventricular disorder AE that is a condition in nwhich the right ventricle of the heart was functionally impaired. This condition usually leads to heart failure or myocardial infarction, and other cardiovascular complicationns. http://purl.obolibrary.org/obo/OAE_0001744 embolism AE http://purl.obolibrary.org/obo/OAE_0000085 vascular disorder AE a vascular disorder AE that is characterized by an obstruction in a blood vessel due to a blood clot or other foreign matter that gets stuck while traveling through the bloodstream. http://purl.obolibrary.org/obo/OAE_0001778 eye inflammation AE http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE an inflammation AE that occurs in eye. http://purl.obolibrary.org/obo/OAE_0001805 Intraoperative hemorrhage AE http://purl.obolibrary.org/obo/OAE_0000427 hemorrhage AE a hemorrhage AE that has an outcome of massive amounts of blood loss. A typical Intraoperative hemorrhage has a blood loss exceeding 1000 mL or requires a blood transfusion http://purl.obolibrary.org/obo/OAE_0001844 joint effusion AE http://purl.obolibrary.org/obo/OAE_0000442 joint disorder AE A joint disorder AE that has the presence of increased intra-articular fluid. It can be caused by trauma, arthritis, or gout and often affects the knee. http://purl.obolibrary.org/obo/OAE_0001876 pelvic pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE Pelvic pain AE is a pain AE that occurs in the lower abdomen area. The pain might be steady, or it might come and go. If the pain is severe, it might get in the way of people's daily activities. http://purl.obolibrary.org/obo/OAE_0001886 uveitis AE http://purl.obolibrary.org/obo/OAE_0001778 eye inflammation AE Uveitis AE is an inflammation AE that is inflammation of the uvea, which lines the inside of the eye behind the cornea. http://purl.obolibrary.org/obo/OAE_0001906 allergic rhinitis AE http://purl.obolibrary.org/obo/OAE_0000350 rhinitis AE Allergic rhinitis AE is a rhinitis AE that is an allergic inflammation of the nasal airways. It occurs when an allergen, such as pollen, dust, or animal dander (particles of shed skin and hair) is inhaled by an individual with a sensitized immune system. http://purl.obolibrary.org/obo/OAE_0001918 cystitis AE http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE Cystitis AE is an inflammation AE that is the medical term for inflammation of the bladder. Most of the time, the inflammation is caused by a bacterial infection, and it's called a urinary tract infection. http://purl.obolibrary.org/obo/OAE_0001928 hoarseness AE http://purl.obolibrary.org/obo/OAE_0000484 voice alteration AE Hoarseness AE is a hoarseness AE that refers to a difficulty making sounds when trying to speak. Vocal sounds may be weak, breathy, scratchy, or husky, and the pitch or quality of the voice may change. http://purl.obolibrary.org/obo/OAE_0001943 ventricular tachycardia AE http://purl.obolibrary.org/obo/OAE_0000355 tachycardia AE Ventricular tachycardia AE is a tachycardia AE that is a type of tachycardia, or a rapid heart beat that arises from improper electrical activity of the heart presenting as a rapid heart rhythm, that starts in the bottom chambers of the heart, called the ventricles. http://purl.obolibrary.org/obo/OAE_0001966 genital edema AE http://purl.obolibrary.org/obo/OAE_0000556 edema AE Genital edema AE is an edema AE that can be the result of interruption to the lymphatic drainage of this area caused by tumor, surgical removal of lymph nodes, radiotherapy or infection. Congenital disorders causing inadequate lymphatics can sometimes lead to the development of this condition. http://purl.obolibrary.org/obo/OAE_0001969 sinus bradycardia AE http://purl.obolibrary.org/obo/OAE_0000218 bradycardia AE Sinus bradycardia AE is a bradycardia AE that is a heart rhythm that originates from the sinus node and has a rate that is lower than normal. In humans, bradycardia is generally defined to be a rate of under 60 beats per minute. http://purl.obolibrary.org/obo/OAE_0001977 hyperthyroidism AE http://purl.obolibrary.org/obo/OAE_0000202 endocrine system AE Hyperthyroidism AE is an endocrine system AE that is a condition in which the thyroid gland produces and secretes excessive amounts of the free (not protein bound circulating in the blood) thyroid hormones -triiodothyronine (T3) and/or thyroxine (T4). http://purl.obolibrary.org/obo/OAE_0001979 retinopathy AE http://purl.obolibrary.org/obo/OAE_0000443 eye AE Retinopathy AE is an eye AE that is due to persistent or acute damage to the retina of the eye. Ongoing inflammation and vascular remodeling may occur over periods of time where the patient is not fully aware of the extent of the disease. Frequently, retinopathy is an ocular manifestation of systemic disease as seen in diabetes or hypertension. http://purl.obolibrary.org/obo/OAE_0002039 induration AE http://purl.obolibrary.org/obo/OAE_0000543 skin AE a skin AE with the outcome of induration, which is an increase in the fibrous elements in tissue commonly associated with inflammation and marked by loss of elasticity and pliability or a hardened mass or formation http://purl.obolibrary.org/obo/OAE_0002058 lymph node pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has an outcome of lymph node pain http://purl.obolibrary.org/obo/OAE_0002080 aphonia AE http://purl.obolibrary.org/obo/OAE_0000426 speech disorder AE a speech disorder AE with an outcome of aphonia, or loss of voice and of all but whispered speech http://purl.obolibrary.org/obo/OAE_0002097 gingival pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has an outcome of pain in gums http://purl.obolibrary.org/obo/OAE_0002117 glaucoma AE http://purl.obolibrary.org/obo/OAE_0000443 eye AE Glaucoma AE is an eye AE that is a term describing a group of ocular (eye) disorders resulting in optic nerve damage or loss to the field of vision, in many patients caused by a clinically characterized pressure buildup in regards to the fluid of the eye (intraocular pressure-associated optic neuropathy). http://purl.obolibrary.org/obo/OAE_0002118 anaphylaxis AE http://purl.obolibrary.org/obo/OAE_0000568 allergy AE an allergy AE that shows a serious allergic reaction that is rapid in onset and may cause death. It typically causes a number of symptoms including an itchy rash, throat swelling, and low blood pressure. Common causes include insect bites and stings, foods, and medications. http://purl.obolibrary.org/obo/OAE_0002129 hearing disorder AE http://purl.obolibrary.org/obo/OAE_0000465 ear AE Hearing disorder AE is an ear disorder that shows impairment of the sense of hearing. http://purl.obolibrary.org/obo/OAE_0002134 coronary heart disease AE http://purl.obolibrary.org/obo/OAE_0000493 cardiovascular AE Coronary heart disease AE is a cardiovascular disorder AE that is a disease in which a waxy substance called plaque (plak) builds up inside the coronary arteries. These arteries supply oxygen-rich blood to your heart muscle. http://purl.obolibrary.org/obo/OAE_0002206 insomnia AE http://purl.obolibrary.org/obo/OAE_0001403 sleep disorder AE a sleep disorder AE in which there is an inability to fall asleep or to stay asleep as long as desired. http://purl.obolibrary.org/obo/OAE_0002223 retinal detachment AE http://purl.obolibrary.org/obo/OAE_0000443 eye AE Retinal detachment AE is an eye AE that is a separation of the retina from its attachments to the underlying tissue within the eye. http://purl.obolibrary.org/obo/OAE_0002349 anal fistula AE http://purl.obolibrary.org/obo/OAE_0004229 anus AE an anus AE that results in the development of a small channel between the end of the bowel and the skin near the anus http://purl.obolibrary.org/obo/OAE_0002364 arachnoiditis AE http://purl.obolibrary.org/obo/OAE_0000558 brain inflammation AE a brain disorder AE that causes inflammation of the arachnoid, one of the membranes known as meninges that surround and protect the nerves of the central nervous system, including the brain and spinal cord. http://purl.obolibrary.org/obo/OAE_0002395 eyelid disorder AE http://purl.obolibrary.org/obo/OAE_0000443 eye AE Eyelid disorder AE is a eye AE that is a condition specifically affects the eyelid. It can include drooping, twitching, inflammation, paralysis, and growths. Occasional fluttering of one eyelid is normal. http://purl.obolibrary.org/obo/OAE_0002400 cholecystitis AE http://purl.obolibrary.org/obo/OAE_0000959 gallbladder enlargement AE cholecystitis AE is an gallbladder enlargement AE that has an outcome of cholecystitis, which is an acute or chronic inflammation involving the gallbladder wall. It may be associated with the presence of gallstones. http://purl.obolibrary.org/obo/OAE_0002421 menstrual disorder AE http://purl.obolibrary.org/obo/OAE_0000082 female reproductive system AE Menstrual disorder AE is an abnormal condition in a woman's menstrual cycle. http://purl.obolibrary.org/obo/OAE_0002425 cognitive disorder AE http://purl.obolibrary.org/obo/OAE_0001797 psychiatric disorder AE a psychiatric disorder AE that is a category of mental health disorders that primarily affect learning, memory, perception, and problem solving, and include amnesia, dementia, and delirium. http://purl.obolibrary.org/obo/OAE_0002437 autoimmune disorder AE http://purl.obolibrary.org/obo/OAE_0000476 immune system AE Autoimmune disorder AE is an immune system AE that arises from an abnormal immune response of the body against substances and tissues normally present in the body (autoimmunity). http://purl.obolibrary.org/obo/OAE_0002527 palpitations AE http://purl.obolibrary.org/obo/OAE_0000660 arrhythmia AE An arrhythmia AE that has an outcome of palpitations, an abnormality of heartbeat characterized by simultaneous awareness of one’s pulse and discomfort. http://purl.obolibrary.org/obo/OAE_0002534 prostatic disorder AE http://purl.obolibrary.org/obo/OAE_0000083 male reproductive system AE A male reproductive system AE that affects prostatic gland in the male reproductive system. http://purl.obolibrary.org/obo/OAE_0002564 telangiectasia AE http://purl.obolibrary.org/obo/OAE_0001502 vein discoloration AE A vein discoloration AE that has an outcome of local dilatation of small vessels resulting in red discoloration of the skin or mucous membranes. http://purl.obolibrary.org/obo/OAE_0002565 trismus AE http://purl.obolibrary.org/obo/OAE_0000521 muscle spasm AE A muscle spasm AE that results in the lack of ability to open the mouth fully due to decreased range of motion of the muscles of mastication. http://purl.obolibrary.org/obo/OAE_0002569 burn AE http://purl.obolibrary.org/obo/OAE_0000041 injury AE an injury AE that displays a type of injury to flesh or skin caused by heat, electricity, chemicals, friction, or radiation. http://purl.obolibrary.org/obo/OAE_0002575 wound AE http://purl.obolibrary.org/obo/OAE_0000041 injury AE an injury AE that breaks the skin or other body tissues. http://purl.obolibrary.org/obo/OAE_0002580 ventricular arrhythmia AE http://purl.obolibrary.org/obo/OAE_0000660 arrhythmia AE an arrhythmia AE that shows abnormal heart rhythms that originate in the bottom chambers of the heart called the ventricles. http://purl.obolibrary.org/obo/OAE_0002593 blood phosphate abnormal AE http://purl.obolibrary.org/obo/OAE_0001574 blood phosphorus abnormal AE a blood phosphorus abnormal AE that shows an abnormal blood phosphate level http://purl.obolibrary.org/obo/OAE_0002594 blood albumin abnormal AE http://purl.obolibrary.org/obo/OAE_0001664 hematology investigation result abnormal AE a hematology investigation result abnormal AE that results in an abnormal level of albumin in the blood http://purl.obolibrary.org/obo/OAE_0002597 blood glucose decreased http://purl.obolibrary.org/obo/PATO_0001018 physical quality A physical quality that has an decreased level of glucose in the blood http://purl.obolibrary.org/obo/OAE_0002598 blood glucose increased http://purl.obolibrary.org/obo/PATO_0001018 physical quality A physical quality that has an increased level of glucose in the blood http://purl.obolibrary.org/obo/OAE_0002600 papulopustular rash AE http://purl.obolibrary.org/obo/OAE_0000362 rash AE A rash AE that is characterized by an eruption consisting of papules (a small, raised pimple) and pustules (a small pus filled blister), typically appearing in face, scalp, and upper chest and back. http://purl.obolibrary.org/obo/OAE_0002601 cranial neuropathy AE http://purl.obolibrary.org/obo/OAE_0000418 neuropathy AE an neuropathy AE that occurs when any of the twelve cranial nerves (nerves that exit from the brain directly) are damaged. http://purl.obolibrary.org/obo/OAE_0002603 cognitive disturbance AE http://purl.obolibrary.org/obo/OAE_0002425 cognitive disorder AE a cognitive disorder AE that shows conspicuous changes in cognitive functions. http://purl.obolibrary.org/obo/OAE_0002606 cardiovascular injury AE http://purl.obolibrary.org/obo/OAE_0000041 injury AE an injury AE that occurs in the cardiovascular system http://purl.obolibrary.org/obo/OAE_0002612 cardiac function test abnormal AE http://purl.obolibrary.org/obo/OAE_0001570 cardiovascular investigation result abnormal AE a cardiovascular investigation result abnormal AE that results in an abnormal result on a test used to evaluate heart function http://purl.obolibrary.org/obo/OAE_0002617 device AE http://purl.obolibrary.org/obo/OAE_0000040 procedural complication AE a procedural complication AE that occurs after the usage of a device. http://purl.obolibrary.org/obo/OAE_0002618 Grade 1 skin ulceration AE http://purl.obolibrary.org/obo/OAE_0000691 skin ulceration AE a skin ulceration AE that has a combined area of ulcers <1 cm and nonblanchable erythema of intact skin with associated warmth or edema http://purl.obolibrary.org/obo/OAE_0002619 Grade 2 skin ulceration AE http://purl.obolibrary.org/obo/OAE_0000691 skin ulceration AE a skin ulceration AE that has a combined area of ulcers 1 - 2 cm and partial thickness skin loss involving skin or subcutaneous fat http://purl.obolibrary.org/obo/OAE_0002620 Grade 3 skin ulceration AE http://purl.obolibrary.org/obo/OAE_0000691 skin ulceration AE a skin ulceration AE that has a combined area of ulcers >2 cm and full-thickness skin loss involving damage to or necrosis of subcutaneous tissue that may extend down to fascia http://purl.obolibrary.org/obo/OAE_0002621 Grade 4 skin ulceration AE http://purl.obolibrary.org/obo/OAE_0000691 skin ulceration AE a skin ulceration AE that has any size ulcer with extensive destruction, tissue necrosis, or damage to muscle, bone, or supporting structures with or without full thickness skin loss http://purl.obolibrary.org/obo/OAE_0002622 Laryngopharyngeal dysesthesia AE http://purl.obolibrary.org/obo/OAE_0002647 dysesthesia AE A dysesthesia AE that shows an uncomfortable persistent sensation in the area of the laryngopharynx. http://purl.obolibrary.org/obo/OAE_0002625 local AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event an adverse event that occurs locally in a certain location. This is different from the systematci adverse event that occurs throughout the systemtic circulation. http://purl.obolibrary.org/obo/OAE_0002629 meninges inflammation AE http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE an inflammation AE which has an outcome of brain inflammation, which is local accumulation of fluid, plasma proteins, and leukocytes in the brain http://purl.obolibrary.org/obo/OAE_0002630 delusions AE http://purl.obolibrary.org/obo/OAE_0001797 psychiatric disorder AE a mental disorder that has false personal beliefs held contrary to reality, despite contradictory evidence and common sense. http://purl.obolibrary.org/obo/OAE_0002631 laryngeal inflammation AE http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE an inflammation AE that has an inflammation involving the larynx. http://purl.obolibrary.org/obo/OAE_0002632 testicular disorder AE http://purl.obolibrary.org/obo/OAE_0000083 male reproductive system AE a male reproductive system AE that has involvement of the testis. http://purl.obolibrary.org/obo/OAE_0002633 urinary frequency AE http://purl.obolibrary.org/obo/OAE_0000622 urinary system AE an urinary system AE that has urination at short intervals. http://purl.obolibrary.org/obo/OAE_0002634 vaginal inflammation AE http://purl.obolibrary.org/obo/OAE_0004306 female reproduction system inflammation AE a reproduction system inflammation AE that has inflammation involving the vagina. Symptoms may include redness, edema, marked discomfort and an increase in vaginal discharge. http://purl.obolibrary.org/obo/OAE_0002635 trigeminal nerve disorder AE http://purl.obolibrary.org/obo/OAE_0002601 cranial neuropathy AE a cranial neuropathy AE that has involvement of the trigeminal nerve (fifth cranial nerve). http://purl.obolibrary.org/obo/OAE_0002636 accessory nerve disorder AE http://purl.obolibrary.org/obo/OAE_0002601 cranial neuropathy AE cranial neuropathy AE that has involvement of the accessory nerve (eleventh cranial nerve). http://purl.obolibrary.org/obo/OAE_0002637 hypoglossal nerve disorder AE http://purl.obolibrary.org/obo/OAE_0002601 cranial neuropathy AE a cranial neuropathy AE that has involvement of the hypoglossal nerve (twelfth cranial nerve). http://purl.obolibrary.org/obo/OAE_0002639 brachial plexopathy AE http://purl.obolibrary.org/obo/OAE_0000171 distal neuropathy AE a distal neuropathy AE that has regional paresthesia of the brachial plexus, marked discomfort and muscle weakness, and limited movement in the arm or hand. http://purl.obolibrary.org/obo/OAE_0002640 acoustic nerve disorder NOS AE http://purl.obolibrary.org/obo/OAE_0002601 cranial neuropathy AE a cranial neuropathy AE that has involvement of the acoustic nerve (eighth cranial nerve) http://purl.obolibrary.org/obo/OAE_0002641 olfactory nerve disorder AE http://purl.obolibrary.org/obo/OAE_0002601 cranial neuropathy AE a cranial neuropathy AE that has involvement of the olfactory nerve (first cranial nerve). http://purl.obolibrary.org/obo/OAE_0002642 glossopharyngeal nerve disorder AE http://purl.obolibrary.org/obo/OAE_0002601 cranial neuropathy AE a cranial neuropathy AE that has involvement of the glossopharyngeal nerve (ninth cranial nerve). http://purl.obolibrary.org/obo/OAE_0002643 vagus nerve disorder AE http://purl.obolibrary.org/obo/OAE_0002601 cranial neuropathy AE a cranial neuropathy AE that has involvement of the vagus nerve (tenth cranial nerve). http://purl.obolibrary.org/obo/OAE_0002644 abducens nerve disorder AE http://purl.obolibrary.org/obo/OAE_0002601 cranial neuropathy AE a cranial neuropathy AE that has involvement of the abducens nerve (sixth cranial nerve). http://purl.obolibrary.org/obo/OAE_0002645 facial nerve disorder AE http://purl.obolibrary.org/obo/OAE_0002601 cranial neuropathy AE a cranial neuropathy AE that has involvement of the facial nerve (seventh cranial nerve). http://purl.obolibrary.org/obo/OAE_0002646 oculomotor nerve disorder AE http://purl.obolibrary.org/obo/OAE_0002601 cranial neuropathy AE a cranial neuropathy AE that has involvement of the oculomotor nerve (third cranial nerve). http://purl.obolibrary.org/obo/OAE_0002647 dysesthesia AE http://purl.obolibrary.org/obo/OAE_0000162 sensory neuropathy AE a sensory neuropathy AE that has distortion of sensory perception, resulting in an abnormal and unpleasant sensation. http://purl.obolibrary.org/obo/OAE_0002648 dyspareunia AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has painful or difficult coitus. http://purl.obolibrary.org/obo/OAE_0002649 exostosis AE http://purl.obolibrary.org/obo/OAE_0000518 bone AE a bone disorder AE that has non-neoplastic overgrowth of bone. http://purl.obolibrary.org/obo/OAE_0002650 gynecomastia AE http://purl.obolibrary.org/obo/OAE_0000202 endocrine system AE an endocrine system AE that has excessive development of the breasts in males. http://purl.obolibrary.org/obo/OAE_0002651 hydrocephalus AE http://purl.obolibrary.org/obo/OAE_0000761 brain edema AE a brain edema AE that has an abnormal increase of cerebrospinal fluid in the ventricles of the brain. http://purl.obolibrary.org/obo/OAE_0002652 lymphedema AE http://purl.obolibrary.org/obo/OAE_0000556 edema AE an edema AE that has excessive fluid collection in tissues that causes swelling. http://purl.obolibrary.org/obo/OAE_0002653 menopause AE http://purl.obolibrary.org/obo/OAE_0002421 menstrual disorder AE a menstrual disorder AE that has the permanent cessation of menses, usually defined by 12 consecutive months of amenorrhea in a woman over 45 years of age. http://purl.obolibrary.org/obo/OAE_0002654 obesity AE http://purl.obolibrary.org/obo/OAE_0001644 physical examination result abnormal AE a physical examination result abnormal AE that is having a high amount of body fat. http://purl.obolibrary.org/obo/OAE_0002655 adult respiratory distress syndrome AE http://purl.obolibrary.org/obo/OAE_0000563 lung inflammation AE a lung inflammation AE that has progressive and life-threatening pulmonary distress in the absence of an underlying pulmonary condition, usually following major trauma or surgery. http://purl.obolibrary.org/obo/OAE_0002656 Superior vena cava syndrome AE http://purl.obolibrary.org/obo/OAE_0000493 cardiovascular AE a cardiovascular AE that has obstruction of the blood flow in the superior vena cava. Signs and symptoms include swelling and cyanosis of the face, neck, and upper arms, cough, orthopnea and headache. http://purl.obolibrary.org/obo/OAE_0002657 dysmenorrhea AE http://purl.obolibrary.org/obo/OAE_0002421 menstrual disorder AE a menstrual disorder AE that has abnormally painful abdominal cramps during menses. http://purl.obolibrary.org/obo/OAE_0002658 euphoria AE http://purl.obolibrary.org/obo/OAE_0000580 behavioral and neurological AE a behavior and neurological AE that has an exaggerated feeling of well-being which is disproportionate to events and stimuli. http://purl.obolibrary.org/obo/OAE_0002659 flank pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has marked discomfort sensation on the lateral side of the body in the region below the ribs and above the hip. http://purl.obolibrary.org/obo/OAE_0002660 glucose intolerance AE http://purl.obolibrary.org/obo/OAE_0001172 metabolic disorder AE a metabolic disorder AE that has an inability to properly metabolize glucose. http://purl.obolibrary.org/obo/OAE_0002661 hemoglobinuria AE http://purl.obolibrary.org/obo/OAE_0000495 urine abnormality AE an urine abnormality AE that has laboratory test results that indicate the presence of free hemoglobin in the urine. http://purl.obolibrary.org/obo/OAE_0002662 hypohidrosis AE http://purl.obolibrary.org/obo/OAE_0000401 sweating AE a sweating AE that has reduced sweating. http://purl.obolibrary.org/obo/OAE_0002663 kyphosis AE http://purl.obolibrary.org/obo/OAE_0000518 bone AE a bone disorder AE that has an abnormal increase in the curvature of the thoracic portion of the spine. http://purl.obolibrary.org/obo/OAE_0002664 lordosis AE http://purl.obolibrary.org/obo/OAE_0000518 bone AE a bone disorder AE that has an abnormal increase in the curvature of the lumbar portion of the spine. http://purl.obolibrary.org/obo/OAE_0002665 oligospermia AE http://purl.obolibrary.org/obo/OAE_0000083 male reproductive system AE a male reproductive system AE that has a decrease in the number of spermatozoa in the semen. http://purl.obolibrary.org/obo/OAE_0002666 avascular necrosis AE http://purl.obolibrary.org/obo/OAE_0000197 necrosis AE a necrosis AE that has necrotic changes in the bone tissue due to interruption of blood supply. Most often affecting the epiphysis of the long bones, the necrotic changes result in the collapse and the destruction of the bone structure. http://purl.obolibrary.org/obo/OAE_0002667 bullous dermatitis AE http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE an inflammation AE that has inflammation of the skin characterized by the presence of bullae which are filled with fluid. http://purl.obolibrary.org/obo/OAE_0002668 dysphasia AE http://purl.obolibrary.org/obo/OAE_0000426 speech disorder AE a speech disorder AE that has impairment of verbal communication skills, often resulting from brain damage. http://purl.obolibrary.org/obo/OAE_0002669 vaginal stricture AE http://purl.obolibrary.org/obo/OAE_0000082 female reproductive system AE a female reproductive system AE that has a narrowing of the vaginal canal. http://purl.obolibrary.org/obo/OAE_0002670 alkalosis AE http://purl.obolibrary.org/obo/OAE_0000069 metabolism, endocrine or exocrine system AE a metabolism, endocrine, and exocrine system AE that has abnormally high alkalinity (low hydrogen-ion concentration) of the blood and other body tissues. http://purl.obolibrary.org/obo/OAE_0002671 Hiccups AE http://purl.obolibrary.org/obo/OAE_0000455 gastrointestinal disorder AE a gastrointestinal disorder AE that has repeated gulp sounds that result from an involuntary opening and closing of the glottis. This is attributed to a spasm of the diaphragm. http://purl.obolibrary.org/obo/OAE_0002672 proteinuria AE http://purl.obolibrary.org/obo/OAE_0000495 urine abnormality AE an urine abnormality AE that has laboratory test results that indicate the presence of excessive protein in the urine. It is predominantly albumin, but also globulin. http://purl.obolibrary.org/obo/OAE_0002673 erythroderma AE http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE an inflammation AE that has generalized inflammatory erythema and exfoliation. The inflammatory process involves > 90% of the body surface area. http://purl.obolibrary.org/obo/OAE_0002674 pyramidal tract syndrome AE http://purl.obolibrary.org/obo/OAE_0000570 nervous system AE a syndrome AE that has dysfunction of the corticospinal (pyramidal) tracts of the spinal cord. Symptoms include an increase in the muscle tone in the lower extremities, hyperreflexia, positive Babinski and a decrease in fine motor coordination. http://purl.obolibrary.org/obo/OAE_0002675 edema cerebral AE http://purl.obolibrary.org/obo/OAE_0000761 brain edema AE a brain edema AE that has swelling due to an excessive accumulation of fluid in the brain. http://purl.obolibrary.org/obo/OAE_0002676 treatment related secondary malignancy AE http://purl.obolibrary.org/obo/OAE_0000052 tumor AE a tumor AE that has development of a malignancy most probably as a result of treatment for a previously existing malignancy. http://purl.obolibrary.org/obo/OAE_0002677 intracranial hemorrhage AE http://purl.obolibrary.org/obo/OAE_0000427 hemorrhage AE a hemorrhage AE that has bleeding from the cranium. http://purl.obolibrary.org/obo/OAE_0002679 transient ischemic attacks AE http://purl.obolibrary.org/obo/OAE_0000198 ischemia AE a ischemia AEE that has a brief attack (less than 24 hours) of cerebral dysfunction of vascular origin, with no persistent neurological deficit. http://purl.obolibrary.org/obo/OAE_0002680 vaginal discharge AE http://purl.obolibrary.org/obo/OAE_0000082 female reproductive system AE afemale reproductive system AE that has vaginal secretions. Mucus produced by the cervical glands is discharged from the vagina naturally, especially during the childbearing years. http://purl.obolibrary.org/obo/OAE_0002681 vasovagal reaction AE http://purl.obolibrary.org/obo/OAE_0000582 sensory capability AE a sensory capability AE that has a sudden drop of the blood pressure, bradycardia, and peripheral vasodilation that may lead to loss of consciousness. It results from an increase in the stimulation of the vagus nerve. http://purl.obolibrary.org/obo/OAE_0002682 premature delivery AE http://purl.obolibrary.org/obo/OAE_0000064 pregnancy AE apregnancy AE that has delivery of a viable infant before the normal end of gestation. Typically, viability is achievable between the twentieth and thirty-seventh week of gestation. http://purl.obolibrary.org/obo/OAE_0002683 mania AE http://purl.obolibrary.org/obo/OAE_0001797 psychiatric disorder AE a psychiatric disorder AE that has excitement of psychotic proportions manifested by mental and physical hyperactivity, disorganization of behavior and elevation of mood. http://purl.obolibrary.org/obo/OAE_0002684 hirsutism AE http://purl.obolibrary.org/obo/OAE_0001021 hair growth abnormal AE a hair growth abnormal AE that has the presence of excess hair growth in women in anatomic sites where growth is considered to be a secondary male characteristic and under androgen control (beard, moustache, chest, abdomen) http://purl.obolibrary.org/obo/OAE_0002685 osteonecrosis of jaw AE http://purl.obolibrary.org/obo/OAE_0000197 necrosis AE a necrosis AE that has a necrotic process occurring in the bone of the mandible. http://purl.obolibrary.org/obo/OAE_0002686 abdominal soft tissue necrosis AE http://purl.obolibrary.org/obo/OAE_0000197 necrosis AE a necrosis AE that has a necrotic process occurring in the soft tissues of the abdominal wall. http://purl.obolibrary.org/obo/OAE_0002687 alcohol intolerance AE http://purl.obolibrary.org/obo/OAE_0001172 metabolic disorder AE a metabolic disorder AE that has an increase in sensitivity to the adverse effects of alcohol, which can include nasal congestion, skin flushes, heart dysrhythmias, nausea, vomiting, indigestion and headaches. http://purl.obolibrary.org/obo/OAE_0002688 anorgasmia AE http://purl.obolibrary.org/obo/OAE_0001797 psychiatric disorder AE a psychiatric disorder AE that has an inability to achieve orgasm. http://purl.obolibrary.org/obo/OAE_0002689 bladder perforation AE http://purl.obolibrary.org/obo/OAE_0000622 urinary system AE an urinary system AE that has a rupture in the bladder wall. http://purl.obolibrary.org/obo/OAE_0002690 bladder spasm AE http://purl.obolibrary.org/obo/OAE_0000622 urinary system AE an urinary system AE that has a sudden and involuntary contraction of the bladder wall. http://purl.obolibrary.org/obo/OAE_0002691 bronchopulmonary hemorrhage AE http://purl.obolibrary.org/obo/OAE_0000427 hemorrhage AE a hemorrhage AE that is bleeding from the bronchial wall and/or lung parenchyma. http://purl.obolibrary.org/obo/OAE_0002692 bronchial obstruction AE http://purl.obolibrary.org/obo/OAE_0000378 respiratory system AE a respiratory system AE that has blockage of a bronchus passage, most often by bronchial secretions and exudates. http://purl.obolibrary.org/obo/OAE_0002693 bronchial stricture AE http://purl.obolibrary.org/obo/OAE_0000378 respiratory system AE a respiratory system AE that has a narrowing of the bronchial tube. http://purl.obolibrary.org/obo/OAE_0002694 central nervous system necrosis AE http://purl.obolibrary.org/obo/OAE_0000197 necrosis AE a necrosis AE that has a necrotic process occurring in the brain and/or spinal cord. http://purl.obolibrary.org/obo/OAE_0002695 chest wall pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has marked discomfort sensation in the chest wall region. http://purl.obolibrary.org/obo/OAE_0002696 cystitis noninfective AE http://purl.obolibrary.org/obo/OAE_0001918 cystitis AE a cystitis AE that has inflammation of the bladder which is not caused by an infection of the urinary tract. http://purl.obolibrary.org/obo/OAE_0002697 delayed orgasm AE http://purl.obolibrary.org/obo/OAE_0001797 psychiatric disorder AE a psychiatric disorder AE that has sexual dysfunction characterized by a delay in climax. http://purl.obolibrary.org/obo/OAE_0002698 ejaculation disorder AE http://purl.obolibrary.org/obo/OAE_0000083 male reproductive system AE a male reproductive system AE that has problems related to ejaculation. This category includes premature, delayed, retrograde and painful ejaculation. http://purl.obolibrary.org/obo/OAE_0002699 facial muscle weakness AE http://purl.obolibrary.org/obo/OAE_0000333 muscular weakness AE a muscular weakness AE that has a reduction in the strength of the facial muscles. http://purl.obolibrary.org/obo/OAE_0002700 fallopian tube obstruction AE http://purl.obolibrary.org/obo/OAE_0000082 female reproductive system AE a female reproductive system AE that has blockage of the normal flow of the contents in the fallopian tube. http://purl.obolibrary.org/obo/OAE_0002701 fallopian tube stenosis AE http://purl.obolibrary.org/obo/OAE_0000082 female reproductive system AE a female reproductive system AE that has a narrowing of the fallopian tube lumen. http://purl.obolibrary.org/obo/OAE_0002702 fat atrophy AE http://purl.obolibrary.org/obo/OAE_0000839 connective tissue disorder AE a connective tissue disorder AE that has shrinking of adipose tissue. http://purl.obolibrary.org/obo/OAE_0002703 female genital tract fistula AE http://purl.obolibrary.org/obo/OAE_0000212 fistula AE a fistula AE that has an abnormal communication between a female reproductive system organ and another organ or anatomic site. http://purl.obolibrary.org/obo/OAE_0002704 feminization acquired AE http://purl.obolibrary.org/obo/OAE_0000202 endocrine system AE an endocrine system AE that has the development of secondary female sex characteristics in males due to extrinsic factors. http://purl.obolibrary.org/obo/OAE_0002705 fibrosis deep connective tissue AE http://purl.obolibrary.org/obo/OAE_0000839 connective tissue disorder AE a connective tissue disorder AE that has fibrotic degeneration of the deep connective tissues. http://purl.obolibrary.org/obo/OAE_0002706 generalized muscle weakness AE http://purl.obolibrary.org/obo/OAE_0000333 muscular weakness AE a muscular weakness AE that has a reduction in the strength of muscles in multiple anatomic sites. http://purl.obolibrary.org/obo/OAE_0002707 growth suppression AE http://purl.obolibrary.org/obo/OAE_0000027 musculoskeletal or connective tissue AE a musculoskeletal and connective tissue AE that has stature that is smaller than normal as expected for age. http://purl.obolibrary.org/obo/OAE_0002708 head soft tissue necrosis AE http://purl.obolibrary.org/obo/OAE_0000197 necrosis AE a necrosis AE that has a necrotic process occurring in the soft tissues of the head. http://purl.obolibrary.org/obo/OAE_0002709 hematosalpinx AE http://purl.obolibrary.org/obo/OAE_0000082 female reproductive system AE a female reproductive system AE that has the presence of blood in a fallopian tube. http://purl.obolibrary.org/obo/OAE_0002710 hypersomnia AE http://purl.obolibrary.org/obo/OAE_0001403 sleep disorder AE a sleep disorder AE that has characterized by excessive sleepiness during the daytime. http://purl.obolibrary.org/obo/OAE_0002711 iron overload AE http://purl.obolibrary.org/obo/OAE_0000555 homeostasis AE a homeostasis AE that has accumulation of iron in the tissues. http://purl.obolibrary.org/obo/OAE_0002712 ischemia cerebrovascular AE http://purl.obolibrary.org/obo/OAE_0000198 ischemia AE an ischemia AE that has a decrease or absence of blood supply to the brain caused by obstruction (thrombosis or embolism) of an artery resulting in neurological damage. http://purl.obolibrary.org/obo/OAE_0002713 IVth nerve disorder AE http://purl.obolibrary.org/obo/OAE_0002601 cranial neuropathy AE a cranial neuropathy AE that has involvement of the trochlear nerve (fourth cranial nerve). http://purl.obolibrary.org/obo/OAE_0002714 joint range of motion decreased cervical spine AE http://purl.obolibrary.org/obo/OAE_0000442 joint disorder AE a joint disorder AE that has a decrease in flexibility of a cervical spine joint. http://purl.obolibrary.org/obo/OAE_0002715 joint range of motion decreased lumbar spine AE http://purl.obolibrary.org/obo/OAE_0000442 joint disorder AE a joint disorder AE that has a decrease in flexibility of a lumbar spine joint. http://purl.obolibrary.org/obo/OAE_0002716 laryngeal fistula AE http://purl.obolibrary.org/obo/OAE_0000212 fistula AE a fistula AE that has an abnormal communication between the larynx and another organ or anatomic site. http://purl.obolibrary.org/obo/OAE_0002717 laryngeal hemorrhage AE http://purl.obolibrary.org/obo/OAE_0000427 hemorrhage AE a hemorrhage AE that has bleeding from the larynx. http://purl.obolibrary.org/obo/OAE_0002718 laryngeal mucositis AE http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE an inflammation AE that has an inflammation involving the mucous membrane of the larynx. http://purl.obolibrary.org/obo/OAE_0002719 laryngeal obstruction AE http://purl.obolibrary.org/obo/OAE_0000378 respiratory system AE a respiratory system AE that has blockage of the laryngeal airway. http://purl.obolibrary.org/obo/OAE_0002720 libido decreased AE http://purl.obolibrary.org/obo/OAE_0001130 libido disorder AE a libido disorder AE that has a decrease in sexual desire. http://purl.obolibrary.org/obo/OAE_0002721 libido increased AE http://purl.obolibrary.org/obo/OAE_0001130 libido disorder AE a libido disorder AE that has an increase in sexual desire. http://purl.obolibrary.org/obo/OAE_0002722 lipohypertrophy AE http://purl.obolibrary.org/obo/OAE_0000543 skin AE a skin AE that has hypertrophy of the subcutaneous adipose tissue at the site of multiple subcutaneous injections of insulin. http://purl.obolibrary.org/obo/OAE_0002723 lymph leakage AE http://purl.obolibrary.org/obo/OAE_0000476 immune system AE an immune system AE that has the loss of lymph fluid into the surrounding tissue or body cavity. http://purl.obolibrary.org/obo/OAE_0002724 lymphocele AE http://purl.obolibrary.org/obo/OAE_0000476 immune system AE an immune system AE that has a cystic lesion containing lymph. http://purl.obolibrary.org/obo/OAE_0002725 mediastinal hemorrhage AE http://purl.obolibrary.org/obo/OAE_0000427 hemorrhage AE a hemorrhage AE that has bleeding from the mediastinum. http://purl.obolibrary.org/obo/OAE_0002726 movements involuntary AE http://purl.obolibrary.org/obo/OAE_0000581 movement disorder AE a movement disorder AE that has uncontrolled and purposeless movements. http://purl.obolibrary.org/obo/OAE_0002727 muscle weakness left-sided AE http://purl.obolibrary.org/obo/OAE_0000333 muscular weakness AE a muscular weakness AE that has a reduction in the strength of the muscles on the left side of the body. http://purl.obolibrary.org/obo/OAE_0002728 muscle weakness lower limb AE http://purl.obolibrary.org/obo/OAE_0000333 muscular weakness AE a muscular weakness AE that has a reduction in the strength of the lower limb muscles. http://purl.obolibrary.org/obo/OAE_0002729 muscle weakness right-sided AE http://purl.obolibrary.org/obo/OAE_0000333 muscular weakness AE a muscular weakness AE that has a reduction in the strength of the muscles on the right side of the body. http://purl.obolibrary.org/obo/OAE_0002730 muscle weakness trunk AE http://purl.obolibrary.org/obo/OAE_0000333 muscular weakness AE a muscular weakness AE that has a reduction in the strength of the trunk muscles. http://purl.obolibrary.org/obo/OAE_0002731 muscle weakness upper limb AE http://purl.obolibrary.org/obo/OAE_0000333 muscular weakness AE a muscular weakness AE that has a reduction in the strength of the upper limb muscles. http://purl.obolibrary.org/obo/OAE_0002732 musculoskeletal deformity AE http://purl.obolibrary.org/obo/OAE_0000027 musculoskeletal or connective tissue AE a musculoskeletal and connective tissue AE that has a malformation of the musculoskeletal system. http://purl.obolibrary.org/obo/OAE_0002733 nail discoloration AE http://purl.obolibrary.org/obo/OAE_0000201 nail AE a nail AE that has a change in the color of the nail plate. http://purl.obolibrary.org/obo/OAE_0002734 nail loss AE http://purl.obolibrary.org/obo/OAE_0000201 nail AE a nail AE that has loss of all or a portion of the nail. http://purl.obolibrary.org/obo/OAE_0002735 nail ridging AE http://purl.obolibrary.org/obo/OAE_0000201 nail AE a nail AE that has vertical or horizontal ridges on the nails. http://purl.obolibrary.org/obo/OAE_0002736 neck soft tissue necrosis AE http://purl.obolibrary.org/obo/OAE_0000197 necrosis AE a necrosis AE that has a necrotic process occurring in the soft tissues of the neck. http://purl.obolibrary.org/obo/OAE_0002737 nipple deformity AE http://purl.obolibrary.org/obo/OAE_0000082 female reproductive system AE a female reproductive system AE that has a malformation of the nipple. http://purl.obolibrary.org/obo/OAE_0002738 ovarian hemorrhage AE http://purl.obolibrary.org/obo/OAE_0000427 hemorrhage AE a hemorrhage AE that has bleeding from the ovary. http://purl.obolibrary.org/obo/OAE_0002739 ovarian rupture AE http://purl.obolibrary.org/obo/OAE_0000082 female reproductive system AE a female reproductive system AE that is tearing or disruption of the ovarian tissue. http://purl.obolibrary.org/obo/OAE_0002740 ovulation pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has marked discomfort sensation in one side of the abdomen between menstrual cycles, around the time of the discharge of the ovum from the ovarian follicle. http://purl.obolibrary.org/obo/OAE_0002741 pelvic floor muscle weakness AE http://purl.obolibrary.org/obo/OAE_0000333 muscular weakness AE a muscular weakness AE that has a reduction in the strength of the muscles of the pelvic floor. http://purl.obolibrary.org/obo/OAE_0002742 pelvic soft tissue necrosis AE http://purl.obolibrary.org/obo/OAE_0000197 necrosis AE a necrosis AE that has a necrotic process occurring in the soft tissues of the pelvis. http://purl.obolibrary.org/obo/OAE_0002743 penile pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has marked discomfort sensation in the penis. http://purl.obolibrary.org/obo/OAE_0002744 personality change AE http://purl.obolibrary.org/obo/OAE_0001797 psychiatric disorder AE a psychiatric disorder AE that has a conspicuous change in a person's behavior and thinking. http://purl.obolibrary.org/obo/OAE_0002745 pharyngeal fistula AE http://purl.obolibrary.org/obo/OAE_0000212 fistula AE a fistula AE that has an abnormal communication between the pharynx and another organ or anatomic site. http://purl.obolibrary.org/obo/OAE_0002746 pharyngeal mucositis AE http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE an inflammation AE that has an inflammation involving the mucous membrane of the pharynx. http://purl.obolibrary.org/obo/OAE_0002747 pharyngeal necrosis AE http://purl.obolibrary.org/obo/OAE_0000197 necrosis AE a necrosis AE that has a necrotic process occurring in the pharynx. http://purl.obolibrary.org/obo/OAE_0002748 pharyngeal stenosis AE http://purl.obolibrary.org/obo/OAE_0000378 respiratory system AE a respiratory system AE that has a narrowing of the pharyngeal airway. http://purl.obolibrary.org/obo/OAE_0002749 prostatic hemorrhage AE http://purl.obolibrary.org/obo/OAE_0000427 hemorrhage AE a hemorrhage AE that has bleeding from the prostate gland. http://purl.obolibrary.org/obo/OAE_0002750 prostatic obstruction AE http://purl.obolibrary.org/obo/OAE_0002534 prostatic disorder AE a prostatic disorder AE that has compression of the urethra secondary to enlargement of the prostate gland. This results in voiding difficulties (straining to void, slow urine stream, and incomplete emptying of the bladder). http://purl.obolibrary.org/obo/OAE_0002751 prostatic pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has a sensation of marked discomfort in the prostate gland. http://purl.obolibrary.org/obo/OAE_0002752 psychosis AE http://purl.obolibrary.org/obo/OAE_0001797 psychiatric disorder AE a psychiatric disorder AE that has personality change, impaired functioning, and loss of touch with reality. It may be a manifestation of schizophrenia, bipolar disorder or brain tumor. http://purl.obolibrary.org/obo/OAE_0002753 pulmonary fistula AE http://purl.obolibrary.org/obo/OAE_0000212 fistula AE a fistula AE that has an abnormal communication between the lung and another organ or anatomic site. http://purl.obolibrary.org/obo/OAE_0002754 radiculitis AE http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE an inflammation AE that has inflammation involving a nerve root. Patients experience marked discomfort radiating along a nerve path because of spinal pressure on the connecting nerve root. http://purl.obolibrary.org/obo/OAE_0002755 recurrent laryngeal nerve palsy AE http://purl.obolibrary.org/obo/OAE_0004344 palsy AE a recurrent alsy AE that occurs at the laryngeal nerve. http://purl.obolibrary.org/obo/OAE_0002756 renal colic AE http://purl.obolibrary.org/obo/OAE_0001937 renal calculus AE a renal calculus AE that has paroxysmal and severe flank marked discomfort radiating to the inguinal area. Often, the cause is the passage of kidney stones. http://purl.obolibrary.org/obo/OAE_0002757 renal hemorrhage AE http://purl.obolibrary.org/obo/OAE_0000427 hemorrhage AE a hemorrhage AE that has bleeding from the kidney. http://purl.obolibrary.org/obo/OAE_0002758 retinoic acid syndrome AE http://purl.obolibrary.org/obo/OAE_0000364 syndrome AE a syndrome AE that has weight gain, dyspnea, pleural and pericardial effusions, leukocytosis and/or renal failure originally described in patients treated with all-trans retinoic acid. http://purl.obolibrary.org/obo/OAE_0002759 scoliosis AE http://purl.obolibrary.org/obo/OAE_0000518 bone AE a bone disorder AE that has a malformed, lateral curvature of the spine. http://purl.obolibrary.org/obo/OAE_0002760 scrotal pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has marked discomfort sensation in the scrotal area. http://purl.obolibrary.org/obo/OAE_0002761 sinus pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has marked discomfort in the face, between the eyes, or upper teeth originating from the sinuses. http://purl.obolibrary.org/obo/OAE_0002762 skin induration AE http://purl.obolibrary.org/obo/OAE_0002039 induration AE an induration AE that has an area of hardness in the skin. http://purl.obolibrary.org/obo/OAE_0002763 soft tissue necrosis lower limb AE http://purl.obolibrary.org/obo/OAE_0000197 necrosis AE a necrosis AE that has a necrotic process occurring in the soft tissues of the lower extremity. http://purl.obolibrary.org/obo/OAE_0002764 soft tissue necrosis upper limb AE http://purl.obolibrary.org/obo/OAE_0000197 necrosis AE a necrosis AE that has a necrotic process occurring in the soft tissues of the upper extremity. http://purl.obolibrary.org/obo/OAE_0002765 spermatic cord hemorrhage AE http://purl.obolibrary.org/obo/OAE_0000427 hemorrhage AE a hemorrhage AE that has bleeding from the spermatic cord. http://purl.obolibrary.org/obo/OAE_0002766 spermatic cord obstruction AE http://purl.obolibrary.org/obo/OAE_0000083 male reproductive system AE a male reproductive system AE that has blockage of the normal flow of the contents of the spermatic cord. http://purl.obolibrary.org/obo/OAE_0002767 superficial soft tissue fibrosis AE http://purl.obolibrary.org/obo/OAE_0000839 connective tissue disorder AE a connective tissue disorder AE that has fibrotic degeneration of the superficial soft tissues. http://purl.obolibrary.org/obo/OAE_0002768 testicular hemorrhage AE http://purl.obolibrary.org/obo/OAE_0000427 hemorrhage AE a hemorrhage AE that has bleeding from the testis. http://purl.obolibrary.org/obo/OAE_0002769 testicular pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has a sensation of marked discomfort in the testis. http://purl.obolibrary.org/obo/OAE_0002770 tracheal fistula AE http://purl.obolibrary.org/obo/OAE_0000212 fistula AE a fistula AE that hasan abnormal communication between the trachea and another organ or anatomic site. http://purl.obolibrary.org/obo/OAE_0002771 tracheal mucositis AE http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE an inflammation AE that has an inflammation involving the mucous membrane of the trachea. http://purl.obolibrary.org/obo/OAE_0002772 tracheal stenosis AE http://purl.obolibrary.org/obo/OAE_0000378 respiratory system AE a respiratory system AE that has a narrowing of the trachea. http://purl.obolibrary.org/obo/OAE_0002773 tumor pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has marked discomfort from a neoplasm that may be pressing on a nerve, blocking blood vessels, inflamed or fractured from metastasis. http://purl.obolibrary.org/obo/OAE_0002774 unequal limb length AE http://purl.obolibrary.org/obo/OAE_0000027 musculoskeletal or connective tissue AE a musculoskeletal and connective tissue AE that hasa discrepancy between the lengths of the lower or upper extremities. http://purl.obolibrary.org/obo/OAE_0002775 urine discoloration AE http://purl.obolibrary.org/obo/OAE_0000495 urine abnormality AE an urine abnormality AE that has a change in the color of the urine. http://purl.obolibrary.org/obo/OAE_0002776 uterine fistula AE http://purl.obolibrary.org/obo/OAE_0000212 fistula AE a fistula AE that has an abnormal communication between the uterus and another organ or anatomic site. http://purl.obolibrary.org/obo/OAE_0002777 uterine obstruction AE http://purl.obolibrary.org/obo/OAE_0000622 urinary system AE an urinary system AE that has blockage of the uterine outlet. http://purl.obolibrary.org/obo/OAE_0002778 uterine pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has a sensation of marked discomfort in the uterus. http://purl.obolibrary.org/obo/OAE_0002779 vaginal dryness AE http://purl.obolibrary.org/obo/OAE_0000082 female reproductive system AE a female reproductive system AE that has an uncomfortable feeling of itching and burning in the vagina. http://purl.obolibrary.org/obo/OAE_0002780 vaginal obstruction AE http://purl.obolibrary.org/obo/OAE_0000082 female reproductive system AE a female reproductive system AE that has blockage of vaginal canal. http://purl.obolibrary.org/obo/OAE_0002781 vaginal pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has a sensation of marked discomfort in the vagina. http://purl.obolibrary.org/obo/OAE_0002782 vaginal perforation AE http://purl.obolibrary.org/obo/OAE_0000082 female reproductive system AE a female reproductive system AE that has a rupture in the vaginal wall. http://purl.obolibrary.org/obo/OAE_0002783 vaginismus AE http://purl.obolibrary.org/obo/OAE_0000082 female reproductive system AE a female reproductive system AE that hasinvoluntary spasms of the pelvic floor muscles, resulting in pathologic tightness of the vaginal wall during penetration such as during sexual intercourse. http://purl.obolibrary.org/obo/OAE_0002784 visceral arterial ischemia AE http://purl.obolibrary.org/obo/OAE_0000198 ischemia AE an ischemia AE that has a decrease in blood supply due to narrowing or blockage of a visceral (mesenteric) artery. http://purl.obolibrary.org/obo/OAE_0002785 body odor AE http://purl.obolibrary.org/obo/OAE_0000543 skin AE a skin AE that has an abnormal body smell resulting from the growth of bacteria on the body. http://purl.obolibrary.org/obo/OAE_0002786 bronchial fistula AE http://purl.obolibrary.org/obo/OAE_0000212 fistula AE a fistula AE that has an abnormal communication between the bronchus and another organ or anatomic site. http://purl.obolibrary.org/obo/OAE_0002787 extrapyramidal disorder AE http://purl.obolibrary.org/obo/OAE_0000570 nervous system AE a nervous system AE that has an abnormal, repetitive, involuntary muscle movements, frenzied speech and extreme restlessness. http://purl.obolibrary.org/obo/OAE_0002788 hypertrichosis AE http://purl.obolibrary.org/obo/OAE_0001021 hair growth abnormal AE a hair growth abnormal AE that has hair density or length beyond the accepted limits of normal in a particular body region, for a particular age or race. http://purl.obolibrary.org/obo/OAE_0002789 lactation disorder AE http://purl.obolibrary.org/obo/OAE_0000082 female reproductive system AE a female reproductive system AE that has disturbances of milk secretion. It is not necessarily related to pregnancy that is observed in females and can be observed in males. http://purl.obolibrary.org/obo/OAE_0002790 laryngeal stenosis AE http://purl.obolibrary.org/obo/OAE_0000378 respiratory system AE a respiratory system AE that has a narrowing of the laryngeal airway. http://purl.obolibrary.org/obo/OAE_0002791 meningismus AE http://purl.obolibrary.org/obo/OAE_0000570 nervous system AE a nervous system AE that has neck stiffness, headache, and photophobia resulting from irritation of the cerebral meninges. http://purl.obolibrary.org/obo/OAE_0002792 phantom pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has marked discomfort related to a limb or an organ that is removed from or is not physically part of the body. http://purl.obolibrary.org/obo/OAE_0002793 scalp pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has marked discomfort sensation in the skin covering the top and the back of the head. http://purl.obolibrary.org/obo/OAE_0002794 unintended pregnancy AE http://purl.obolibrary.org/obo/OAE_0000064 pregnancy AE a pregnancy AE that has an unexpected pregnancy at the time of conception. http://purl.obolibrary.org/obo/OAE_0002795 urinary tract obstruction AE http://purl.obolibrary.org/obo/OAE_0000622 urinary system AE an urinary system AE that has blockage of the normal flow of contents of the urinary tract. http://purl.obolibrary.org/obo/OAE_0002796 vaginal fistula AE http://purl.obolibrary.org/obo/OAE_0000212 fistula AE a fistula AE that has an abnormal communication between the vagina and another organ or anatomic site. http://purl.obolibrary.org/obo/OAE_0002797 urinary fistula AE http://purl.obolibrary.org/obo/OAE_0000212 fistula AE a fistula AE that has an abnormal communication between any part of the urinary system and another organ or anatomic site. http://purl.obolibrary.org/obo/OAE_0002798 azoospermia AE http://purl.obolibrary.org/obo/OAE_0000083 male reproductive system AE a male reproductive system AE that has laboratory test results that indicate complete absence of spermatozoa in the semen. http://purl.obolibrary.org/obo/OAE_0002799 chronic kidney disease AE http://purl.obolibrary.org/obo/OAE_0001364 renal failure AE a renal failure AE that has gradual and usually permanent loss of kidney function resulting in renal failure. http://purl.obolibrary.org/obo/OAE_0002800 concentration impairment AE http://purl.obolibrary.org/obo/OAE_0000580 behavioral and neurological AE a behavior and neurological AE that has a deterioration in the ability to concentrate. http://purl.obolibrary.org/obo/OAE_0002801 fetal growth retardation AE http://purl.obolibrary.org/obo/OAE_0000519 fetal disorder AE a fetal disorder AE that has inhibition of fetal growth resulting in the inability of the fetus to achieve its potential weight. http://purl.obolibrary.org/obo/OAE_0002802 premature menopause AE http://purl.obolibrary.org/obo/OAE_0002421 menstrual disorder AE a menstrual disorder AE that has ovarian failure before the age of 40. Symptoms include hot flashes, night sweats, mood swings and a decrease in sex drive. http://purl.obolibrary.org/obo/OAE_0002803 leukemia secondary to oncology chemotherapy AE http://purl.obolibrary.org/obo/OAE_0000052 tumor AE a tumor AE that has leukemia arising as a result of the mutagenic effect of chemotherapy agents. http://purl.obolibrary.org/obo/OAE_0002804 bronchopleural fistula AE http://purl.obolibrary.org/obo/OAE_0000212 fistula AE a fistula AE that has an abnormal communication between a bronchus and the pleural cavity. http://purl.obolibrary.org/obo/OAE_0002805 urinary tract pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE a pain AE that has a sensation of marked discomfort in the urinary tract. http://purl.obolibrary.org/obo/OAE_0002806 breast atrophy AE http://purl.obolibrary.org/obo/OAE_0000082 female reproductive system AE a female reproductive system AE that has underdevelopment of the breast. http://purl.obolibrary.org/obo/OAE_0002807 medical procedure http://purl.obolibrary.org/obo/OAE_0000002 medical intervention a medical intervention that refers to any series of pre-defined steps that should be followed to achieve a desired result. http://purl.obolibrary.org/obo/OAE_0002810 Grade 1 lymphedema AE http://purl.obolibrary.org/obo/OAE_0002652 lymphedema AE a hymphedema AE that has trace thickening or faint discoloration http://purl.obolibrary.org/obo/OAE_0002811 Grade 2 lymphedema AE http://purl.obolibrary.org/obo/OAE_0002652 lymphedema AE a hymphedema AE that has marked discoloration; leathery skin texture; papillary formation; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0002812 Grade 1 superior vena cava syndrome AE http://purl.obolibrary.org/obo/OAE_0002656 Superior vena cava syndrome AE a superior vena cava syndrome AE that has asymptomatic; incidental finding of SVC thrombosis http://purl.obolibrary.org/obo/OAE_0002813 Grade 2 superior vena cava syndrome AE http://purl.obolibrary.org/obo/OAE_0002656 Superior vena cava syndrome AE a superior vena cava syndrome AEthat has symptomatic; medical intervention indicated (e.g., anticoagulation, radiation or chemotherapy) http://purl.obolibrary.org/obo/OAE_0002814 Grade 3 superior vena cava syndrome AE http://purl.obolibrary.org/obo/OAE_0002656 Superior vena cava syndrome AE a superior vena cava syndrome AE that has severe symptoms; multi-modality intervention indicated (e.g., anticoagulation, chemotherapy, radiation, stenting) http://purl.obolibrary.org/obo/OAE_0002815 Grade 4 superior vena cava syndrome AE http://purl.obolibrary.org/obo/OAE_0002656 Superior vena cava syndrome AE a superior vena cava syndrome AE that has life-threatening consequences; urgent multi-modality intervention indicated (e.g., lysis, thrombectomy, surgery) http://purl.obolibrary.org/obo/OAE_0002816 Grade 1 thromboembolic event AE http://purl.obolibrary.org/obo/OAE_0002605 thromboembolism AE a thromboembolic event AE that has venous thrombosis (e.g., superficial thrombosis) http://purl.obolibrary.org/obo/OAE_0002817 Grade 2 thromboembolic event AE http://purl.obolibrary.org/obo/OAE_0002605 thromboembolism AE a thromboembolic event AE that has venous thrombosis (e.g., uncomplicated deep vein thrombosis), medical intervention indicated http://purl.obolibrary.org/obo/OAE_0002818 Grade 3 thromboembolic event AE http://purl.obolibrary.org/obo/OAE_0002605 thromboembolism AE a thromboembolic event AE that has thrombosis (e.g., uncomplicated pulmonary embolism [venous], non-embolic cardiac mural [arterial] thrombus), medical intervention indicated http://purl.obolibrary.org/obo/OAE_0002819 Grade 4 thromboembolic event AE http://purl.obolibrary.org/obo/OAE_0002605 thromboembolism AE a thromboembolic event AE that has life-threatening (e.g., pulmonary embolism, cerebrovascular event, arterial insufficiency); hemodynamic or neurologic instability; urgent intervention indicated http://purl.obolibrary.org/obo/OAE_0002820 Grade 2 visceral arterial ischemia AE http://purl.obolibrary.org/obo/OAE_0002784 visceral arterial ischemia AE a visceral arterial ischemia AE that has brief (<24 hrs) episode of ischemia managed medically and without permanent deficit http://purl.obolibrary.org/obo/OAE_0002821 Grade 3 visceral arterial ischemia AE http://purl.obolibrary.org/obo/OAE_0002784 visceral arterial ischemia AE a visceral arterial ischemia AE that has prolonged (>=24 hrs) or recurring symptoms and/or invasive intervention indicated http://purl.obolibrary.org/obo/OAE_0002822 Grade 1 menopause AE http://purl.obolibrary.org/obo/OAE_0002653 menopause AE a menopause AE that the menopause occurres at age 46 - 53 years of age http://purl.obolibrary.org/obo/OAE_0002823 Grade 2 menopause AE http://purl.obolibrary.org/obo/OAE_0002653 menopause AE a menopause AE that the menopause occurres at age 40 - 45 years of age http://purl.obolibrary.org/obo/OAE_0002824 Grade 3 menopause AE http://purl.obolibrary.org/obo/OAE_0002653 menopause AE a menopause AE that the menopause occurres before age 40 years of age http://purl.obolibrary.org/obo/OAE_0002825 Grade 1 body odor AE http://purl.obolibrary.org/obo/OAE_0002785 body odor AE a body odor AE that has mild odor; physician intervention not indicated; self care interventions http://purl.obolibrary.org/obo/OAE_0002826 Grade 2 body odor AE http://purl.obolibrary.org/obo/OAE_0002785 body odor AE a body odor AE that has pronounced odor; psychosocial impact; patient seeks medical intervention http://purl.obolibrary.org/obo/OAE_0002827 Grade 1 bullous dermatitis AE http://purl.obolibrary.org/obo/OAE_0002667 bullous dermatitis AE a bullous AE that has asymptomatic; blisters covering <10% BSA http://purl.obolibrary.org/obo/OAE_0002828 Grade 2 bullous dermatitis AE http://purl.obolibrary.org/obo/OAE_0002667 bullous dermatitis AE a bullous AE that has blisters covering 10 - 30% BSA; painful blisters; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0002829 Grade 3 bullous dermatitis AE http://purl.obolibrary.org/obo/OAE_0002667 bullous dermatitis AE a bullous AE that has blisters covering >30% BSA; limiting self care ADL http://purl.obolibrary.org/obo/OAE_0002830 Grade 4 bullous dermatitis AE http://purl.obolibrary.org/obo/OAE_0002667 bullous dermatitis AE a bullous AE that has blisters covering >30% BSA; associated with fluid or electrolyte abnormalities; ICU care or burn unit indicated http://purl.obolibrary.org/obo/OAE_0002831 Grade 2 erythroderma AE http://purl.obolibrary.org/obo/OAE_0002673 erythroderma AE an erythroderma AE that has erythema covering >90% BSA without associated symptoms; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0002832 Grade 3 erythroderma AE http://purl.obolibrary.org/obo/OAE_0002673 erythroderma AE an erythroderma AE that has erythema covering >90% BSA with associated symptoms (e.g., pruritus or tenderness); limiting self care ADL http://purl.obolibrary.org/obo/OAE_0002833 Grade 4 erythroderma AE http://purl.obolibrary.org/obo/OAE_0002673 erythroderma AE an erythroderma AE that has erythema covering >90% BSA with associated fluid or electrolyte abnormalities; ICU care or burn unit indicated http://purl.obolibrary.org/obo/OAE_0002834 Grade 1 fat atrophy AE http://purl.obolibrary.org/obo/OAE_0002702 fat atrophy AE a fat atrophy AE that is covering <10% BSA and asymptomatic http://purl.obolibrary.org/obo/OAE_0002835 Grade 2 fat atrophy AE http://purl.obolibrary.org/obo/OAE_0002702 fat atrophy AE a fat atrophy AE that is covering 10 - 30% BSA and associated with erythema or tenderness; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0002836 Grade 3 fat atrophy AE http://purl.obolibrary.org/obo/OAE_0002702 fat atrophy AE a fat atrophy AE that is covering >30% BSA; associated with erythema or tenderness; limiting self-care ADL http://purl.obolibrary.org/obo/OAE_0002837 Grade 1 hirsutism AE http://purl.obolibrary.org/obo/OAE_0002684 hirsutism AE a hirsutism AE that is In women, increase in length, thickness or density of hair in a male distribution that the patient is able to camouflage by periodic shaving, bleaching, or removal of hair http://purl.obolibrary.org/obo/OAE_0002838 Grade 2 hirsutism AE http://purl.obolibrary.org/obo/OAE_0002684 hirsutism AE a hirsutism AE that In women, increase in length, thickness or density of hair in a male distribution that requires daily shaving or consistent destructive means of hair removal to camouflage; associated with psychosocial impact http://purl.obolibrary.org/obo/OAE_0002839 Grade 1 hypertrichosis AE http://purl.obolibrary.org/obo/OAE_0002788 hypertrichosis AE a hypertrichosis AE that has increased in length, thickness or density of hair. The patient is either able to camouflage by periodic shaving or removal of hairs or is not concerned enough about the overgrowth to use any form of hair removal http://purl.obolibrary.org/obo/OAE_0002840 Grade 2 hypertrichosis AE http://purl.obolibrary.org/obo/OAE_0002788 hypertrichosis AE a hypertrichosis AE that has increased in length, thickness or density of hair at least on the usual exposed areas of the body [face (not limited to beard/moustache area) plus/minus arms] that requires frequent shaving or use of destructive means of hair removal to camouflage; associated with psychosocial impact http://purl.obolibrary.org/obo/OAE_0002841 Grade 3 hypohidrosis AE http://purl.obolibrary.org/obo/OAE_0002662 hypohidrosis AE a hypertrichosis AE that has increased in body temperature; limiting self care ADL http://purl.obolibrary.org/obo/OAE_0002842 Grade 4 hypohidrosis AE http://purl.obolibrary.org/obo/OAE_0002662 hypohidrosis AE a hypertrichosis AE that has heat stroke http://purl.obolibrary.org/obo/OAE_0002843 Grade 1 lipohypertrophy AE http://purl.obolibrary.org/obo/OAE_0002722 lipohypertrophy AE a lipohypertrophy AE that has asymptomatic and covering <10% BSA http://purl.obolibrary.org/obo/OAE_0002844 Grade 2 lipohypertrophy AE http://purl.obolibrary.org/obo/OAE_0002722 lipohypertrophy AE a lipohypertrophy AE that covers 10 - 30% BSA and associated tenderness; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0002845 Grade 3 lipohypertrophy AE http://purl.obolibrary.org/obo/OAE_0002722 lipohypertrophy AE a lipohypertrophy AE that covers >30% BSA and associated tenderness and narcotics or NSAIDs indicated; lipohypertrophy; limiting self care ADL http://purl.obolibrary.org/obo/OAE_0002846 Grade 1 nail loss AE http://purl.obolibrary.org/obo/OAE_0002734 nail loss AE a nail loss AE that has asymptomatic separation of the nail bed from the nail plate or nail loss http://purl.obolibrary.org/obo/OAE_0002847 Grade 2 nail loss AE http://purl.obolibrary.org/obo/OAE_0002734 nail loss AE a nail loss AE that has symptomatic separation of the nail bed from the nail plate or nail loss; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0002848 Grade 1 rash acneiform AE http://purl.obolibrary.org/obo/OAE_0002599 acneiform rash AE a rash acneiform AE that has papules and/or pustules covering <10% BSA, which may or may not be associated with symptoms of pruritus or tenderness http://purl.obolibrary.org/obo/OAE_0002849 Grade 2 rash acneiform AE http://purl.obolibrary.org/obo/OAE_0002599 acneiform rash AE a rash acneiform AE that has papules and/or pustules covering 10 - 30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; associated with psychosocial impact; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0002850 Grade 3 rash acneiform AE http://purl.obolibrary.org/obo/OAE_0002599 acneiform rash AE a rash acneiform AE that has papules and/or pustules covering >30% BSA, which may or may not be associated with symptoms of pruritus or tenderness; limiting self care ADL; associated with local superinfection with oral antibiotics indicated http://purl.obolibrary.org/obo/OAE_0002851 Grade 4 rash acneiform AE http://purl.obolibrary.org/obo/OAE_0002599 acneiform rash AE a rash acneiform AE that has papules and/or pustules covering any % BSA, which may or may not be associated with symptoms of pruritus or tenderness and are associated with extensive superinfection with IV antibiotics indicated; life-threatening consequences http://purl.obolibrary.org/obo/OAE_0002852 Grade 1 rash maculo-papular AE http://purl.obolibrary.org/obo/OAE_0000384 maculo-papular rash AE a rash maculopapular AE that has macules/papules covering <10% BSA with or without symptoms (e.g., pruritus, burning, tightness) http://purl.obolibrary.org/obo/OAE_0002853 Grade 2 rash maculo-papular AE http://purl.obolibrary.org/obo/OAE_0000384 maculo-papular rash AE a rash maculopapular AE that has macules/papules covering 10 - 30% BSA with or without symptoms (e.g., pruritus, burning, tightness); limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0002854 Grade 3 rash maculo-papular AE http://purl.obolibrary.org/obo/OAE_0000384 maculo-papular rash AE a rash maculopapular AE that has macules/papules covering >30% BSA with or without associated symptoms; limiting self care ADL http://purl.obolibrary.org/obo/OAE_0002855 Grade 1 skin induration AE http://purl.obolibrary.org/obo/OAE_0002762 skin induration AE a skin induration AE that has mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up) http://purl.obolibrary.org/obo/OAE_0002856 Grade 2 skin induration AE http://purl.obolibrary.org/obo/OAE_0002762 skin induration AE a skin induration AE that has moderate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0002857 Grade 3 skin induration AE http://purl.obolibrary.org/obo/OAE_0002762 skin induration AE a skin induration AE that has severe induration, unable to slide or pinch skin; limiting joint movement or orifice (e.g., mouth, anus); limiting self care ADL http://purl.obolibrary.org/obo/OAE_0002858 Grade 4 skin induration AE http://purl.obolibrary.org/obo/OAE_0002762 skin induration AE a skin induration AE that has generalized; associated with signs or symptoms of impaired breathing or feeding http://purl.obolibrary.org/obo/OAE_0002859 Grade 2 bronchial fistula AE http://purl.obolibrary.org/obo/OAE_0002786 bronchial fistula AE a bronchial fistula AE that has symptomatic; tube thoracostomy or medical management indicated; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0002860 Grade 3 bronchial fistula AE http://purl.obolibrary.org/obo/OAE_0002786 bronchial fistula AE a bronchial fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) http://purl.obolibrary.org/obo/OAE_0002861 Grade 4 bronchial fistula AE http://purl.obolibrary.org/obo/OAE_0002786 bronchial fistula AE a bronchial fistula AE that has life-threatening consequences; urgent operative intervention with thoracoplasty, chronic open drainage or multiple thoracotomies indicated http://purl.obolibrary.org/obo/OAE_0002862 Grade 2 bronchial obstruction AE http://purl.obolibrary.org/obo/OAE_0002692 bronchial obstruction AE a bronchial obstruction AE that has symptomatic (e.g., mild wheezing); endoscopic evaluation indicated; radiographic evidence of atelectasis/lobar collapse; medical management indicated (e.g., steroids, bronchodilators) http://purl.obolibrary.org/obo/OAE_0002863 Grade 3 bronchial obstruction AE http://purl.obolibrary.org/obo/OAE_0002692 bronchial obstruction AE a bronchial obstruction AE that has shortness of breath with stridor; endoscopic intervention indicated (e.g., laser, stent placement) http://purl.obolibrary.org/obo/OAE_0002864 Grade 2 bronchial stricture AE http://purl.obolibrary.org/obo/OAE_0002693 bronchial stricture AE a bronchial stricture AE that AE symptomatic (e.g., rhonchi or wheezing) but without respiratory distress; medical intervention indicated (e.g., steroids, bronchodilators) http://purl.obolibrary.org/obo/OAE_0002865 Grade 3 bronchial stricture AE http://purl.obolibrary.org/obo/OAE_0002693 bronchial stricture AE a bronchial stricture AE that AE shortness of breath with stridor; endoscopic intervention indicated (e.g., laser, stent placement) http://purl.obolibrary.org/obo/OAE_0002866 Grade 3 bronchopleural fistula AE http://purl.obolibrary.org/obo/OAE_0002804 bronchopleural fistula AE a bronchopleural fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) http://purl.obolibrary.org/obo/OAE_0002867 Grade 4 bronchopleural fistula AE http://purl.obolibrary.org/obo/OAE_0002804 bronchopleural fistula AE a bronchopleural fistula AE that has life-threatening consequences; urgent operative intervention with thoracoplasty, chronic open drainage or multiple thoracotomies indicated http://purl.obolibrary.org/obo/OAE_0002868 Grade 2 laryngeal fistula AE http://purl.obolibrary.org/obo/OAE_0002716 laryngeal fistula AE a laryngeal fistula AE that has symptomatic; tube thoracostomy or medical management indicated; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0002869 Grade 3 laryngeal fistula AE http://purl.obolibrary.org/obo/OAE_0002716 laryngeal fistula AE a laryngeal fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) http://purl.obolibrary.org/obo/OAE_0002870 Grade 4 laryngeal fistula AE http://purl.obolibrary.org/obo/OAE_0002716 laryngeal fistula AE a laryngeal fistula AE that has life-threatening consequences; urgent operative intervention indicated (e.g., thoracoplasty, chronic open drainage or multiple thoracotomies) http://purl.obolibrary.org/obo/OAE_0002871 Grade 1 laryngeal hemorrhage AE http://purl.obolibrary.org/obo/OAE_0002717 laryngeal hemorrhage AE a laryngeal hemorrhage AE that has mild cough or trace hemoptysis; laryngoscopic findings http://purl.obolibrary.org/obo/OAE_0002872 Grade 1 laryngeal inflammation AE http://purl.obolibrary.org/obo/OAE_0002631 laryngeal inflammation AE a laryngeal inflammation AE that has mild sore throat; raspy voice http://purl.obolibrary.org/obo/OAE_0002873 Grade 2 laryngeal inflammation AE http://purl.obolibrary.org/obo/OAE_0002631 laryngeal inflammation AE a laryngeal inflammation AE that has moderate sore throat; analgesics indicated http://purl.obolibrary.org/obo/OAE_0002874 Grade 3 laryngeal inflammation AE http://purl.obolibrary.org/obo/OAE_0002631 laryngeal inflammation AE a laryngeal inflammation AE that has severe throat pain; endoscopic intervention indicated http://purl.obolibrary.org/obo/OAE_0002875 Grade 1 laryngeal mucositis AE http://purl.obolibrary.org/obo/OAE_0002718 laryngeal mucositis AE a laryngeal mucositis AE that has endoscopic findings only; mild discomfort with normal intake http://purl.obolibrary.org/obo/OAE_0002876 Grade 2 laryngeal mucositis AE http://purl.obolibrary.org/obo/OAE_0002718 laryngeal mucositis AE a laryngeal mucositis AE that has moderate discomfort; altered oral intake http://purl.obolibrary.org/obo/OAE_0002877 Grade 3 laryngeal mucositis AE http://purl.obolibrary.org/obo/OAE_0002718 laryngeal mucositis AE a laryngeal mucositis AE that has severe pain; severely altered eating/swallowing; medical intervention indicated http://purl.obolibrary.org/obo/OAE_0002878 Grade 4 laryngeal mucositis AE http://purl.obolibrary.org/obo/OAE_0002718 laryngeal mucositis AE a laryngeal mucositis AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) http://purl.obolibrary.org/obo/OAE_0002879 Grade 2 laryngeal obstruction AE http://purl.obolibrary.org/obo/OAE_0002719 laryngeal obstruction AE a laryngeal obstruction AE that has symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids); limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0002880 Grade 3 laryngeal obstruction AE http://purl.obolibrary.org/obo/OAE_0002719 laryngeal obstruction AE a laryngeal obstruction AE that has limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser) http://purl.obolibrary.org/obo/OAE_0002881 Grade 2 laryngeal stenosis AE http://purl.obolibrary.org/obo/OAE_0002790 laryngeal stenosis AE a laryngeal stenosis AE that has symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids) http://purl.obolibrary.org/obo/OAE_0002882 Grade 3 laryngeal stenosis AE http://purl.obolibrary.org/obo/OAE_0002790 laryngeal stenosis AE a laryngeal stenosis AE that has limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser) http://purl.obolibrary.org/obo/OAE_0002883 Grade 2 laryngopharyngeal dysesthesia AE http://purl.obolibrary.org/obo/OAE_0002622 Laryngopharyngeal dysesthesia AE a laryngopharyngeal dysesthesia AE that has moderate symptoms; mild anxiety, but no dyspnea; short duration of observation and or anxiolytic indicated; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0002884 Grade 3 laryngopharyngeal dysesthesia AE http://purl.obolibrary.org/obo/OAE_0002622 Laryngopharyngeal dysesthesia AE a laryngopharyngeal dysesthesia AE that has severe symptoms; dyspnea and swallowing difficulty; limiting self care ADL http://purl.obolibrary.org/obo/OAE_0002885 Grade 2 laryngospasm AE http://purl.obolibrary.org/obo/OAE_0000677 laryngospasm AE a laryngospasm AE that has transient episode; intervention not indicated http://purl.obolibrary.org/obo/OAE_0002886 Grade 3 laryngospasm AE http://purl.obolibrary.org/obo/OAE_0000677 laryngospasm AE a laryngospasm AE that has recurrent episodes; noninvasive intervention indicated (e.g., breathing technique, pressure point massage) http://purl.obolibrary.org/obo/OAE_0002887 Grade 4 laryngospasm AE http://purl.obolibrary.org/obo/OAE_0000677 laryngospasm AE a laryngospasm AE that has persistent or severe episodes associated with syncope; urgent intervention indicated (e.g., fiberoptic laryngoscopy, intubation, botox injection) http://purl.obolibrary.org/obo/OAE_0002888 Grade 2 pharyngeal fistula AE http://purl.obolibrary.org/obo/OAE_0002745 pharyngeal fistula AE a pharyngeal fistula AE that has symptomatic; tube thoracostomy or medical intervention indicated; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0002889 Grade 3 pharyngeal fistula AE http://purl.obolibrary.org/obo/OAE_0002745 pharyngeal fistula AE a pharyngeal fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) http://purl.obolibrary.org/obo/OAE_0002890 Grade 1 pharyngeal mucositis AE http://purl.obolibrary.org/obo/OAE_0002746 pharyngeal mucositis AE a pharyngeal mucositis AE that has endoscopic findings only; minimal symptoms with normal oral intake; mild pain but analgesics not indicated http://purl.obolibrary.org/obo/OAE_0002891 Grade 2 pharyngeal mucositis AE http://purl.obolibrary.org/obo/OAE_0002746 pharyngeal mucositis AE a pharyngeal mucositis AE that has moderate pain and analgesics indicated; altered oral intake; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0002892 Grade 3 pharyngeal mucositis AE http://purl.obolibrary.org/obo/OAE_0002746 pharyngeal mucositis AE a pharyngeal mucositis AE that has severe pain; unable to adequately aliment or hydrate orally; limiting self care ADL http://purl.obolibrary.org/obo/OAE_0002893 Grade 3 pharyngeal necrosis AE http://purl.obolibrary.org/obo/OAE_0002747 pharyngeal necrosis AE a pharyngeal necrosis AE that has inability to aliment adequately by GI tract; tube feeding or TPN indicated; radiologic, endoscopic, or operative intervention indicated http://purl.obolibrary.org/obo/OAE_0002894 Grade 2 pharyngeal stenosis AE http://purl.obolibrary.org/obo/OAE_0002748 pharyngeal stenosis AE a pharyngeal stenosis AE that has symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids); limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0002895 Grade 3 pharyngeal stenosis AE http://purl.obolibrary.org/obo/OAE_0002748 pharyngeal stenosis AE a pharyngeal stenosis AE that has limiting self care ADL; stridor; endoscopic intervention indicated (e.g., stent, laser) http://purl.obolibrary.org/obo/OAE_0002896 Grade 4 pharyngeal stenosis AE http://purl.obolibrary.org/obo/OAE_0002748 pharyngeal stenosis AE a pharyngeal stenosis AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) http://purl.obolibrary.org/obo/OAE_0002897 Grade 2 pulmonary fistula AE http://purl.obolibrary.org/obo/OAE_0002753 pulmonary fistula AE a pulmonary fistula AE that has symptomatic; tube thoracostomy or medical management indicated; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0002898 Grade 3 pulmonary fistula AE http://purl.obolibrary.org/obo/OAE_0002753 pulmonary fistula AE a pulmonary fistula AE that has limiting self care ADL; endoscopic stenting or operative intervention indicated http://purl.obolibrary.org/obo/OAE_0002899 Grade 1 retinoic acid syndrome AE http://purl.obolibrary.org/obo/OAE_0002758 retinoic acid syndrome AE a retinoic acid syndrome AE that has fluid retention; <3 kg of weight gain; intervention with fluid restriction and/or diuretics indicated http://purl.obolibrary.org/obo/OAE_0002900 Grade 1 sleep apnea AE http://purl.obolibrary.org/obo/OAE_0001789 sleep apnea AE a sleep apnea AE that has snoring and nocturnal sleep arousal without apneic periods http://purl.obolibrary.org/obo/OAE_0002901 Grade 2 sleep apnea AE http://purl.obolibrary.org/obo/OAE_0001789 sleep apnea AE a sleep apnea AE that has moderate apnea and oxygen desaturation; excessive daytime sleepiness; medical evaluation indicated; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0002902 Grade 3 sleep apnea AE http://purl.obolibrary.org/obo/OAE_0001789 sleep apnea AE a sleep apnea AE that has oxygen desaturation; associated with hypertension; medical intervention indicated; limiting self care ADL http://purl.obolibrary.org/obo/OAE_0002903 Grade 4 sleep apnea AE http://purl.obolibrary.org/obo/OAE_0001789 sleep apnea AE a sleep apnea AE that has cardiovascular or neuropsychiatric symptoms; urgent operative intervention indicated http://purl.obolibrary.org/obo/OAE_0002904 Grade 2 tracheal fistula AE http://purl.obolibrary.org/obo/OAE_0002770 tracheal fistula AE a tracheal fistula AE that has symptomatic; tube thoracostomy or medical intervention indicated; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0002905 Grade 3 tracheal fistula AE http://purl.obolibrary.org/obo/OAE_0002770 tracheal fistula AE a tracheal fistula AE that has severe symptoms; limiting self care ADL; endoscopic or operative intervention indicated (e.g., stent or primary closure) http://purl.obolibrary.org/obo/OAE_0002906 Grade 4 tracheal fistula AE http://purl.obolibrary.org/obo/OAE_0002770 tracheal fistula AE a tracheal fistula AE that has life-threatening consequences; urgent operative intervention indicated (e.g., thoracoplasty, chronic open drainage or multiple thoracotomies) http://purl.obolibrary.org/obo/OAE_0002907 Grade 1 tracheal mucositis AE http://purl.obolibrary.org/obo/OAE_0002771 tracheal mucositis AE a tracheal mucositis AE that has endoscopic findings only; minimal hemoptysis, pain, or respiratory symptoms http://purl.obolibrary.org/obo/OAE_0002908 Grade 3 tracheal mucositis AE http://purl.obolibrary.org/obo/OAE_0002771 tracheal mucositis AE a tracheal mucositis AE that has severe pain; hemorrhage or respiratory symptoms; limiting self care ADL http://purl.obolibrary.org/obo/OAE_0002909 Grade 2 tracheal stenosis AE http://purl.obolibrary.org/obo/OAE_0002772 tracheal stenosis AE a tracheal stenosis AE that has symptomatic (e.g., noisy airway breathing), but causing no respiratory distress; medical management indicated (e.g., steroids) http://purl.obolibrary.org/obo/OAE_0002910 Grade 3 tracheal stenosis AE http://purl.obolibrary.org/obo/OAE_0002772 tracheal stenosis AE a tracheal stenosis AE that has stridor or respiratory distress limiting self care ADL; endoscopic intervention indicated (e.g., stent, laser) http://purl.obolibrary.org/obo/OAE_0002911 Grade 4 tracheal stenosis AE http://purl.obolibrary.org/obo/OAE_0002772 tracheal stenosis AE a tracheal stenosis AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) http://purl.obolibrary.org/obo/OAE_0002912 Grade 3 azoospermia AE http://purl.obolibrary.org/obo/OAE_0002798 azoospermia AE an azoospermia AE that has absence of sperm in ejaculate http://purl.obolibrary.org/obo/OAE_0002913 Grade 3 breast atrophy AE http://purl.obolibrary.org/obo/OAE_0002806 breast atrophy AE A breast atrophy AE that has asymmetry >1/3 of breast volume; severe atrophy http://purl.obolibrary.org/obo/OAE_0002914 Grade 1 ejaculation disorder AE http://purl.obolibrary.org/obo/OAE_0002698 ejaculation disorder AE an ejaculation disorder AE that has diminished ejaculation http://purl.obolibrary.org/obo/OAE_0002915 Grade 2 ejaculation disorder AE http://purl.obolibrary.org/obo/OAE_0002698 ejaculation disorder AE an ejaculation disorder AE that has anejaculation or retrograde ejaculation http://purl.obolibrary.org/obo/OAE_0002916 Grade 1 genital edema AE http://purl.obolibrary.org/obo/OAE_0001966 genital edema AE a genital edema AE that has mild swelling or obscuration of anatomic architecture on close inspection http://purl.obolibrary.org/obo/OAE_0002917 Grade 2 genital edema AE http://purl.obolibrary.org/obo/OAE_0001966 genital edema AE a genital edema AE that has readily apparent obscuration of anatomic architecture; obliteration of skin folds; readily apparent deviation from normal anatomic contour http://purl.obolibrary.org/obo/OAE_0002918 Grade 3 genital edema AE http://purl.obolibrary.org/obo/OAE_0001966 genital edema AE a genital edema AE that has lymphorrhea; gross deviation from normal anatomic contour; limiting self care ADL http://purl.obolibrary.org/obo/OAE_0002919 Grade 1 gynecomastia AE http://purl.obolibrary.org/obo/OAE_0002650 gynecomastia AE a gynecomastia AE that has asymptomatic breast enlargement http://purl.obolibrary.org/obo/OAE_0002920 Grade 2 gynecomastia AE http://purl.obolibrary.org/obo/OAE_0002650 gynecomastia AE a gynecomastia AE that has symptomatic (e.g., pain or psychosocial impact) http://purl.obolibrary.org/obo/OAE_0002921 Grade 1 hematosalpinx AE http://purl.obolibrary.org/obo/OAE_0002709 hematosalpinx AE a hematosalpinx AE that has minimal bleeding identified on imaging study or laparoscopy; intervention not indicated http://purl.obolibrary.org/obo/OAE_0002922 Grade 1 irregular menstruation AE http://purl.obolibrary.org/obo/OAE_0002439 menstruation irregular AE an irregular menstruation AE that has intermittent menses with skipped menses for no more than 1 to 3 months http://purl.obolibrary.org/obo/OAE_0002923 Grade 2 irregular menstruation AE http://purl.obolibrary.org/obo/OAE_0002439 menstruation irregular AE an irregular menstruation AE that has intermittent menses with skipped menses for more than 4 to 6 months http://purl.obolibrary.org/obo/OAE_0002924 Grade 3 irregular menstruation AE http://purl.obolibrary.org/obo/OAE_0002439 menstruation irregular AE an irregular menstruation AE that has persistent amenorrhea for more than 6 months http://purl.obolibrary.org/obo/OAE_0002925 Grade 1 lactation disorder AE http://purl.obolibrary.org/obo/OAE_0002789 lactation disorder AE a lactation disorder AE that has mild changes in lactation, not significantly affecting production or expression of breast milk http://purl.obolibrary.org/obo/OAE_0002926 Grade 2 lactation disorder AE http://purl.obolibrary.org/obo/OAE_0002789 lactation disorder AE a lactation disorder AE that has changes in lactation, significantly affecting breast production or expression of breast milk http://purl.obolibrary.org/obo/OAE_0002927 Grade 1 nipple deformity AE http://purl.obolibrary.org/obo/OAE_0002737 nipple deformity AE a nipple deformity AE that has asymptomatic; asymmetry with slight retraction and/or thickening of the nipple areolar complex http://purl.obolibrary.org/obo/OAE_0002928 Grade 2 nipple deformity AE http://purl.obolibrary.org/obo/OAE_0002737 nipple deformity AE a nipple deformity AE that has symptomatic; asymmetry of nipple areolar complex with moderate retraction and/or thickening of the nipple areolar complex http://purl.obolibrary.org/obo/OAE_0002929 Grade 1 oligospermia AE http://purl.obolibrary.org/obo/OAE_0002665 oligospermia AE an oligospermia AE requires sperm concentration >48 million/mL or motility >68% http://purl.obolibrary.org/obo/OAE_0002930 Grade 2 oligospermia AE http://purl.obolibrary.org/obo/OAE_0002665 oligospermia AE an oligospermia AE requires sperm concentration 13 - 48 million/mL or motility 32 - 68% http://purl.obolibrary.org/obo/OAE_0002931 Grade 3 oligospermia AE http://purl.obolibrary.org/obo/OAE_0002665 oligospermia AE an oligospermia AE requires sperm concentration <13 million/mL or motility <32% http://purl.obolibrary.org/obo/OAE_0002932 Grade 2 testicular disorder AE http://purl.obolibrary.org/obo/OAE_0002632 testicular disorder AE a testicular disorder AE that has symptomatic but not interfering with urination or sexual activities; intervention not indicated; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0002933 Grade 3 testicular disorder AE http://purl.obolibrary.org/obo/OAE_0002632 testicular disorder AE a testicular disorder AE that has severe symptoms; interfering with urination or sexual function; limiting self care ADL; intervention indicated http://purl.obolibrary.org/obo/OAE_0002934 Grade 1 vaginal discharge AE http://purl.obolibrary.org/obo/OAE_0002680 vaginal discharge AE a vaginal discharge AE that has mild vaginal discharge (greater than baseline for patient) http://purl.obolibrary.org/obo/OAE_0002935 Grade 2 vaginal discharge AE http://purl.obolibrary.org/obo/OAE_0002680 vaginal discharge AE a vaginal discharge AE that has moderate to heavy vaginal discharge; use of perineal pad or tampon indicated http://purl.obolibrary.org/obo/OAE_0002936 Grade 2 bladder spasm AE http://purl.obolibrary.org/obo/OAE_0002690 bladder spasm AE a bladder spasm AE that has antispasmodics indicated http://purl.obolibrary.org/obo/OAE_0002937 Grade 3 bladder spasm AE http://purl.obolibrary.org/obo/OAE_0002690 bladder spasm AE a bladder spasm AE that has hospitalization indicated http://purl.obolibrary.org/obo/OAE_0002938 Grade 1 chronic kidney disease AE http://purl.obolibrary.org/obo/OAE_0002799 chronic kidney disease AE a chronic kidney disease AE that requires eGFR (estimated Glomerular Filtration Rate) or CrCl (creatinine clearance) 0.5 http://purl.obolibrary.org/obo/OAE_0002939 Grade 2 chronic kidney disease AE http://purl.obolibrary.org/obo/OAE_0002799 chronic kidney disease AE a chronic kidney disease AE that requires eGFR or CrCl 59 - 30 ml/min/1.73 m2 http://purl.obolibrary.org/obo/OAE_0002940 Grade 3 chronic kidney disease AE http://purl.obolibrary.org/obo/OAE_0002799 chronic kidney disease AE a chronic kidney disease AE that requires eGFR or CrCl 29 - 15 ml/min/1.73 m2 http://purl.obolibrary.org/obo/OAE_0002941 Grade 4 chronic kidney disease AE http://purl.obolibrary.org/obo/OAE_0002799 chronic kidney disease AE a chronic kidney disease AE that requires eGFR or CrCl <15 ml/min/1.73 m2; dialysis or renal transplant indicated http://purl.obolibrary.org/obo/OAE_0002942 Grade 1 cystitis noninfective AE http://purl.obolibrary.org/obo/OAE_0002696 cystitis noninfective AE a cystitis noninfective AE that has microscopic hematuria; minimal increase in frequency, urgency, dysuria, or nocturia; new onset of incontinence http://purl.obolibrary.org/obo/OAE_0002943 Grade 2 cystitis noninfective AE http://purl.obolibrary.org/obo/OAE_0002696 cystitis noninfective AE a cystitis noninfective AE that has moderate hematuria; moderate increase in frequency, urgency, dysuria, nocturia or incontinence; urinary catheter placement or bladder irrigation indicated; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0002945 Grade 1 proteinuria AE http://purl.obolibrary.org/obo/OAE_0002672 proteinuria AE a proteinuria AE that requires 1+ proteinuria; urinary protein <1.0 g/24 hrs http://purl.obolibrary.org/obo/OAE_0002946 Grade 2 proteinuria AE http://purl.obolibrary.org/obo/OAE_0002672 proteinuria AE a proteinuria AE that requires http://purl.obolibrary.org/obo/OAE_0002947 Grade 3 proteinuria AE http://purl.obolibrary.org/obo/OAE_0002672 proteinuria AE a proteinuria AE that requires http://purl.obolibrary.org/obo/OAE_0002948 Grade 1 renal calculi AE http://purl.obolibrary.org/obo/OAE_0001937 renal calculus AE a renal calculi AE that has asymptomatic or mild symptoms; occasional use of nonprescription analgesics indicated http://purl.obolibrary.org/obo/OAE_0002949 Grade 2 renal calculi AE http://purl.obolibrary.org/obo/OAE_0001937 renal calculus AE a renal calculi AE that has symptomatic; oral antiemetics indicated; around the clock nonprescription analgesics or any oral narcotic analgesics indicated http://purl.obolibrary.org/obo/OAE_0002950 Grade 3 renal calculi AE http://purl.obolibrary.org/obo/OAE_0001937 renal calculus AE a renal calculi AE that has hospitalization indicated; IV intervention (e.g., analgesics, antiemetics); elective endoscopic or radiologic intervention indicated http://purl.obolibrary.org/obo/OAE_0002951 Grade 2 urinary fistula AE http://purl.obolibrary.org/obo/OAE_0002797 urinary fistula AE an urinary fistula AE that has noninvasive intervention indicated; urinary or suprapubic catheter placement indicated http://purl.obolibrary.org/obo/OAE_0002952 Grade 3 urinary fistula AE http://purl.obolibrary.org/obo/OAE_0002797 urinary fistula AE an urinary fistula AE that has limiting self care ADL; elective radiologic, endoscopic or operative intervention indicated; permanent urinary diversion indicated http://purl.obolibrary.org/obo/OAE_0002953 Grade 2 urinary tract obstruction AE http://purl.obolibrary.org/obo/OAE_0002795 urinary tract obstruction AE an urinary tract obstruction AE that has symptomatic but no hydronephrosis, sepsis or renal dysfunction; urethral dilation, urinary or suprapubic catheter indicated http://purl.obolibrary.org/obo/OAE_0002954 Grade 3 urinary tract obstruction AE http://purl.obolibrary.org/obo/OAE_0002795 urinary tract obstruction AE an urinary tract obstruction AE that has symptomatic and altered organ function (e.g., hydronephrosis, or renal dysfunction); elective radiologic, endoscopic or operative intervention indicated http://purl.obolibrary.org/obo/OAE_0002955 Grade 1 mania AE http://purl.obolibrary.org/obo/OAE_0002683 mania AE a mania AE that has mild manic symptoms (e.g., elevated mood, rapid thoughts, rapid speech, decreased need for sleep) http://purl.obolibrary.org/obo/OAE_0002956 Grade 2 mania AE http://purl.obolibrary.org/obo/OAE_0002683 mania AE a mania AE that has moderate manic symptoms (e.g., relationship and work difficulties; poor hygiene) http://purl.obolibrary.org/obo/OAE_0002957 Grade 3 mania AE http://purl.obolibrary.org/obo/OAE_0002683 mania AE a mania AE that has severe manic symptoms (e.g., hypomania; major sexual or financial indiscretions); hospitalization not indicated http://purl.obolibrary.org/obo/OAE_0002958 Grade 2 fetal growth retardation AE http://purl.obolibrary.org/obo/OAE_0002801 fetal growth retardation AE a fetal growth retardation AE that has <10% percentile of weight for gestational age http://purl.obolibrary.org/obo/OAE_0002959 Grade 3 fetal growth retardation AE http://purl.obolibrary.org/obo/OAE_0002801 fetal growth retardation AE a fetal growth retardation AE that has <5% percentile of weight for gestational age http://purl.obolibrary.org/obo/OAE_0002960 Grade 4 fetal growth retardation AE http://purl.obolibrary.org/obo/OAE_0002801 fetal growth retardation AE a fetal growth retardation AE that has <1% percentile of weight for gestational age http://purl.obolibrary.org/obo/OAE_0002961 Grade 1 premature delivery AE http://purl.obolibrary.org/obo/OAE_0002682 premature delivery AE a premature delivery AE that has delivery of a liveborn infant at >34 to 37 weeks gestation http://purl.obolibrary.org/obo/OAE_0002962 Grade 2 premature delivery AE http://purl.obolibrary.org/obo/OAE_0002682 premature delivery AE a premature delivery AE that has delivery of a liveborn infant at >28 to 34 weeks gestation http://purl.obolibrary.org/obo/OAE_0002963 Grade 3 premature delivery AE http://purl.obolibrary.org/obo/OAE_0002682 premature delivery AE a premature delivery AE that has delivery of a liveborn infant at 24 to 28 weeks gestation http://purl.obolibrary.org/obo/OAE_0002964 Grade 4 premature delivery AE http://purl.obolibrary.org/obo/OAE_0002682 premature delivery AE a premature delivery AE that has delivery of a liveborn infant at 24 weeks of gestation or less http://purl.obolibrary.org/obo/OAE_0002965 Grade 1 spasticity AE http://purl.obolibrary.org/obo/OAE_0002521 muscle spasticity AE a spasticity AE that has mild or slight increase in muscle tone http://purl.obolibrary.org/obo/OAE_0002966 Grade 2 spasticity AE http://purl.obolibrary.org/obo/OAE_0002521 muscle spasticity AE a spasticity AE that has moderate increase in muscle tone and increase in resistance through range of motion http://purl.obolibrary.org/obo/OAE_0002967 Grade 3 spasticity AE http://purl.obolibrary.org/obo/OAE_0002521 muscle spasticity AE a spasticity AE that has severe increase in muscle tone and increase in resistance through range of motion http://purl.obolibrary.org/obo/OAE_0002968 Grade 4 spasticity AE http://purl.obolibrary.org/obo/OAE_0002521 muscle spasticity AE a spasticity AE that has life-threatening; unable to move active or passive range of motion http://purl.obolibrary.org/obo/OAE_0002969 Grade 3 treatment related secondary malignancy AE http://purl.obolibrary.org/obo/OAE_0002676 treatment related secondary malignancy AE a treatment related secondary malignancy AE that has non life-threatening secondary malignancy http://purl.obolibrary.org/obo/OAE_0002970 Grade 4 treatment related secondary malignancy AE http://purl.obolibrary.org/obo/OAE_0002676 treatment related secondary malignancy AE a treatment related secondary malignancy AE that has acute life-threatening secondary malignancy; blast crisis in leukemia http://purl.obolibrary.org/obo/OAE_0002971 Grade 2 abdominal soft tissue necrosis AE http://purl.obolibrary.org/obo/OAE_0002686 abdominal soft tissue necrosis AE an abdominal soft tissue necrosis AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications) http://purl.obolibrary.org/obo/OAE_0002972 Grade 3 abdominal soft tissue necrosis AE http://purl.obolibrary.org/obo/OAE_0002686 abdominal soft tissue necrosis AE an abdominal soft tissue necrosis AE that has operative debridement or other invasive intervention indicated (e.g. tissue reconstruction, flap or grafting) http://purl.obolibrary.org/obo/OAE_0002973 Grade 1 fibrosis deep connective tissue AE http://purl.obolibrary.org/obo/OAE_0002705 fibrosis deep connective tissue AE a fibrosis deep connective tissue AE that has mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up) http://purl.obolibrary.org/obo/OAE_0002974 Grade 2 fibrosis deep connective tissue AE http://purl.obolibrary.org/obo/OAE_0002705 fibrosis deep connective tissue AE a fibrosis deep connective tissue AE that has moderate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0002975 Grade 3 fibrosis deep connective tissue AE http://purl.obolibrary.org/obo/OAE_0002705 fibrosis deep connective tissue AE a fibrosis deep connective tissue AE that has severe induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g. mouth, anus); limiting self care ADL http://purl.obolibrary.org/obo/OAE_0002976 Grade 4 fibrosis deep connective tissue AE http://purl.obolibrary.org/obo/OAE_0002705 fibrosis deep connective tissue AE a fibrosis deep connective tissue AE that has generalized; associated with signs or symptoms of impaired breathing or feeding http://purl.obolibrary.org/obo/OAE_0002977 Grade 1 growth suppression AE http://purl.obolibrary.org/obo/OAE_0002707 growth suppression AE a growth suppression AE that has reduction in growth velocity by 10 - 29% ideally measured over the period of a year http://purl.obolibrary.org/obo/OAE_0002978 Grade 2 growth suppression AE http://purl.obolibrary.org/obo/OAE_0002707 growth suppression AE a growth suppression AE that has reduction in growth velocity by 30 - 49% ideally measured over the period of a year or 0 - 49% reduction in growth from the baseline growth curve http://purl.obolibrary.org/obo/OAE_0002979 Grade 3 growth suppression AE http://purl.obolibrary.org/obo/OAE_0002707 growth suppression AE a growth suppression AE that has reduction in growth velocity of >=50% ideally measured over the period of a year http://purl.obolibrary.org/obo/OAE_0002980 Grade 2 head soft tissue necrosis AE http://purl.obolibrary.org/obo/OAE_0002708 head soft tissue necrosis AE a head soft tissue necrosis AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications) http://purl.obolibrary.org/obo/OAE_0002981 Grade 3 head soft tissue necrosis AE http://purl.obolibrary.org/obo/OAE_0002708 head soft tissue necrosis AE a head soft tissue necrosis AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) http://purl.obolibrary.org/obo/OAE_0002982 Grade 1 joint range of motion decreased cervical spine AE http://purl.obolibrary.org/obo/OAE_0002714 joint range of motion decreased cervical spine AE a joint range of motion decreased cervical spine AE that has mild restriction of rotation or flexion between 60 - 70 degrees http://purl.obolibrary.org/obo/OAE_0002983 Grade 2 joint range of motion decreased cervical spine AE http://purl.obolibrary.org/obo/OAE_0002714 joint range of motion decreased cervical spine AE a joint range of motion decreased cervical spine AE that has rotation <60 degrees to right or left; <60 degrees of flexion http://purl.obolibrary.org/obo/OAE_0002984 Grade 3 joint range of motion decreased cervical spine AE http://purl.obolibrary.org/obo/OAE_0002714 joint range of motion decreased cervical spine AE a joint range of motion decreased cervical spine AE that has ankylosed/fused over multiple segments with no C-spine rotation http://purl.obolibrary.org/obo/OAE_0002985 Grade 1 joint range of motion decreased lumbar spine AE http://purl.obolibrary.org/obo/OAE_0002715 joint range of motion decreased lumbar spine AE a joint range of motion decreased lumbar spine AE that has stiffness; difficulty bending to the floor to pick up a very light object but able to do athletic activity http://purl.obolibrary.org/obo/OAE_0002986 Grade 2 joint range of motion decreased lumbar spine AE http://purl.obolibrary.org/obo/OAE_0002715 joint range of motion decreased lumbar spine AE a joint range of motion decreased lumbar spine AE that has pain with range of motion (ROM) in lumbar spine; requires a reaching aid to pick up a very light object from the floor http://purl.obolibrary.org/obo/OAE_0002987 Grade 3 joint range of motion decreased lumbar spine AE http://purl.obolibrary.org/obo/OAE_0002715 joint range of motion decreased lumbar spine AE a joint range of motion decreased lumbar spine AE that requires <50% lumbar spine flexion; associated with symptoms of ankylosis or fused over multiple segments with no L-spine flexion (e.g., unable to reach to floor to pick up a very light object) http://purl.obolibrary.org/obo/OAE_0002988 Grade 2 neck soft tissue necrosis AE http://purl.obolibrary.org/obo/OAE_0002736 neck soft tissue necrosis AE a neck soft tissue necrosis AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications) http://purl.obolibrary.org/obo/OAE_0002989 Grade 3 neck soft tissue necrosis AE http://purl.obolibrary.org/obo/OAE_0002736 neck soft tissue necrosis AE a neck soft tissue necrosis AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) http://purl.obolibrary.org/obo/OAE_0002990 Grade 2 pelvic soft tissue necrosis AE http://purl.obolibrary.org/obo/OAE_0002742 pelvic soft tissue necrosis AE a pelvic soft tissue necrosis AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications) http://purl.obolibrary.org/obo/OAE_0002991 Grade 3 pelvic soft tissue necrosis AE http://purl.obolibrary.org/obo/OAE_0002742 pelvic soft tissue necrosis AE a pelvic soft tissue necrosis AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) http://purl.obolibrary.org/obo/OAE_0002992 Grade 1 scoliosis AE http://purl.obolibrary.org/obo/OAE_0002759 scoliosis AE a scoliosis AE that requires <20 degrees; clinically undetectable http://purl.obolibrary.org/obo/OAE_0002993 Grade 2 scoliosis AE http://purl.obolibrary.org/obo/OAE_0002759 scoliosis AE a scoliosis AE that requires >20 - 45 degrees; visible by forward flexion; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0002994 Grade 3 scoliosis AE http://purl.obolibrary.org/obo/OAE_0002759 scoliosis AE a scoliosis AE that requires >45 degrees; scapular prominence in forward flexion; operative intervention indicated; limiting self care ADL; disabling http://purl.obolibrary.org/obo/OAE_0002995 Grade 2 soft tissue necrosis lower limb AE http://purl.obolibrary.org/obo/OAE_0002763 soft tissue necrosis lower limb AE a soft tissue necrosis lower limb AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications) http://purl.obolibrary.org/obo/OAE_0002996 Grade 3 soft tissue necrosis lower limb AE http://purl.obolibrary.org/obo/OAE_0002763 soft tissue necrosis lower limb AE a soft tissue necrosis lower limb AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) http://purl.obolibrary.org/obo/OAE_0002997 Grade 2 soft tissue necrosis upper limb AE http://purl.obolibrary.org/obo/OAE_0002764 soft tissue necrosis upper limb AE a soft tissue necrosis upper limb AE that has local wound care; medical intervention indicated (e.g., dressings or topical medications) http://purl.obolibrary.org/obo/OAE_0002998 Grade 3 soft tissue necrosis upper limb AE http://purl.obolibrary.org/obo/OAE_0002764 soft tissue necrosis upper limb AE a soft tissue necrosis upper limb AE that has operative debridement or other invasive intervention indicated (e.g., tissue reconstruction, flap or grafting) http://purl.obolibrary.org/obo/OAE_0002999 Grade 1 superficial soft tissue fibrosis AE http://purl.obolibrary.org/obo/OAE_0002767 superficial soft tissue fibrosis AE a Superficial soft tissue fibrosis AE that has mild induration, able to move skin parallel to plane (sliding) and perpendicular to skin (pinching up) http://purl.obolibrary.org/obo/OAE_0003000 Grade 2 superficial soft tissue fibrosis AE http://purl.obolibrary.org/obo/OAE_0002767 superficial soft tissue fibrosis AE a Superficial soft tissue fibrosis AE that has moderate induration, able to slide skin, unable to pinch skin; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0003001 Grade 3 superficial soft tissue fibrosis AE http://purl.obolibrary.org/obo/OAE_0002767 superficial soft tissue fibrosis AE a Superficial soft tissue fibrosis AE that has severe induration; unable to slide or pinch skin; limiting joint or orifice movement (e.g., mouth, anus); limiting self care ADL http://purl.obolibrary.org/obo/OAE_0003002 Grade 4 superficial soft tissue fibrosis AE http://purl.obolibrary.org/obo/OAE_0002767 superficial soft tissue fibrosis AE a superficial soft tissue fibrosis AE that has generalized; associated with signs or symptoms of impaired breathing or feeding http://purl.obolibrary.org/obo/OAE_0003003 Grade 1 trismus AE http://purl.obolibrary.org/obo/OAE_0002565 trismus AE a trismus AE that has decreased ROM (range of motion) without impaired eating http://purl.obolibrary.org/obo/OAE_0003004 Grade 2 trismus AE http://purl.obolibrary.org/obo/OAE_0002565 trismus AE a trismus AE that has decreased ROM requiring small bites, soft foods or purees http://purl.obolibrary.org/obo/OAE_0003005 Grade 3 trismus AE http://purl.obolibrary.org/obo/OAE_0002565 trismus AE a trismus AE that has decreased ROM with inability to adequately aliment or hydrate orally http://purl.obolibrary.org/obo/OAE_0003006 Grade 1 unequal limb length AE http://purl.obolibrary.org/obo/OAE_0002774 unequal limb length AE An unequal limb length AE that has mild length discrepancy <2 cm http://purl.obolibrary.org/obo/OAE_0003007 Grade 2 unequal limb length AE http://purl.obolibrary.org/obo/OAE_0002774 unequal limb length AE An unequal limb length AE that has moderate length discrepancy 2 - 5 cm; shoe lift indicated; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0003008 Grade 3 unequal limb length AE http://purl.obolibrary.org/obo/OAE_0002774 unequal limb length AE An unequal limb length AE that has severe length discrepancy >5 cm; limiting self care ADL; disabling; operative intervention indicated http://purl.obolibrary.org/obo/OAE_0003009 Grade 1 alkalosis AE http://purl.obolibrary.org/obo/OAE_0002670 alkalosis AE a alkalosis AE that requires pH >normal, but <=7.5 http://purl.obolibrary.org/obo/OAE_0003010 Grade 3 alkalosis AE http://purl.obolibrary.org/obo/OAE_0002670 alkalosis AE a alkalosis AE that requires pH >7.5 http://purl.obolibrary.org/obo/OAE_0003011 Grade 2 glucose intolerance AE http://purl.obolibrary.org/obo/OAE_0002660 glucose intolerance AE a glucose intolerance AE that has symptomatic; dietary modification or oral agent indicated http://purl.obolibrary.org/obo/OAE_0003012 Grade 3 glucose intolerance AE http://purl.obolibrary.org/obo/OAE_0002660 glucose intolerance AE a glucose intolerance AE that has severe symptoms; insulin indicated http://purl.obolibrary.org/obo/OAE_0003013 Grade 1 hypermagnesemia AE http://purl.obolibrary.org/obo/OAE_0000683 hypermagnesemia AE a hypermagnesemia AE that requires >ULN - 3.0 mg/dL; >ULN - 1.23 mmol/L http://purl.obolibrary.org/obo/OAE_0003014 Grade 3 hypermagnesemia AE http://purl.obolibrary.org/obo/OAE_0000683 hypermagnesemia AE a hypermagnesemia AE that requires >3.0 - 8.0 mg/dL; >1.23 - 3.30 mmol/L http://purl.obolibrary.org/obo/OAE_0003015 Grade 4 hypermagnesemia AE http://purl.obolibrary.org/obo/OAE_0000683 hypermagnesemia AE a hypermagnesemia AE that requires >8.0 mg/dL; >3.30 mmol/L; life-threatening consequences http://purl.obolibrary.org/obo/OAE_0003016 Grade 1 hypernatremia AE http://purl.obolibrary.org/obo/OAE_0002538 hypernatremia AE a hypernatremia AE that requires >ULN - 150 mmol/L http://purl.obolibrary.org/obo/OAE_0003017 Grade 2 hypernatremia AE http://purl.obolibrary.org/obo/OAE_0002538 hypernatremia AE a hypernatremia AE that requires >150 - 155 mmol/L http://purl.obolibrary.org/obo/OAE_0003018 Grade 3 hypernatremia AE http://purl.obolibrary.org/obo/OAE_0002538 hypernatremia AE a hypernatremia AE that requires >155 - 160 mmol/L; hospitalization indicated http://purl.obolibrary.org/obo/OAE_0003019 Grade 4 hypernatremia AE http://purl.obolibrary.org/obo/OAE_0002538 hypernatremia AE a hypernatremia AE that requires >160 mmol/L; life-threatening consequences http://purl.obolibrary.org/obo/OAE_0003020 Grade 1 hypokalemia AE http://purl.obolibrary.org/obo/OAE_0002582 hypokalaemia AE a hypokalemia AE that requires =40 kg/m2 http://purl.obolibrary.org/obo/OAE_0003030 Grade 3 flushing AE http://purl.obolibrary.org/obo/OAE_0000021 flushing AE a flushing AE that has symptomatic, associated with hypotension and/or tachycardia; limiting self care ADL http://purl.obolibrary.org/obo/OAE_0003031 Grade 2 hematoma AE http://purl.obolibrary.org/obo/OAE_0000650 hematoma AE a hematoma AE that requires minimally invasive evacuation or aspiration http://purl.obolibrary.org/obo/OAE_0003032 Grade 3 hematoma AE http://purl.obolibrary.org/obo/OAE_0000650 hematoma AE a hematoma AE that requires transfusion, radiologic, endoscopic, or elective operative intervention http://purl.obolibrary.org/obo/OAE_0003033 Grade 1 hypertension AE http://purl.obolibrary.org/obo/OAE_0000403 hypertension AE an hypertension AE that has prehypertension (systolic BP 120 - 139 mm Hg or diastolic BP 80 - 89 mm Hg) http://purl.obolibrary.org/obo/OAE_0003034 Grade 2 hypertension AE http://purl.obolibrary.org/obo/OAE_0000403 hypertension AE an hypertension AE that for Adult: has stage 1 hypertension (systolic BP 140 - 159 mm Hg or diastolic BP 90 - 99 mm Hg); medical intervention indicated; recurrent or persistent (>=24 hrs); symptomatic increase by >20 mm Hg (diastolic) or to >140/90 mm Hg if previously WNL; monotherapy indicated; for Pediatric: recurrent or persistent (>=24 hrs) BP >ULN; monotherapy indicated. http://purl.obolibrary.org/obo/OAE_0003035 Grade 3 hypertension AE http://purl.obolibrary.org/obo/OAE_0000403 hypertension AE an hypertension AE that for Adult has Stage 2 hypertension (systolic BP >=160 mm Hg or diastolic BP >=100 mm Hg); medical intervention indicated; more than one drug or more intensive therapy than previously used indicated; for Pediatric: Same as adult. http://purl.obolibrary.org/obo/OAE_0003036 Grade 4 hypertension AE http://purl.obolibrary.org/obo/OAE_0000403 hypertension AE an hypertension AE that for Adult has life-threatening consequences (e.g., malignant hypertension, transient or permanent neurologic deficit, hypertensive crisis); urgent intervention indicated; for Pediatric: Same as adult http://purl.obolibrary.org/obo/OAE_0003037 Grade 2 peripheral ischemia AE http://purl.obolibrary.org/obo/OAE_0001285 peripheral ischemia AE a peripheral ischaemia AE that has brief (<24 hrs) episode of ischemia managed non-surgically and without permanent deficit http://purl.obolibrary.org/obo/OAE_0003038 Grade 3 peripheral ischemia AE http://purl.obolibrary.org/obo/OAE_0001285 peripheral ischemia AE a peripheral ischaemia AE that has a recurring or prolonged (>=24 hrs) and/or invasive intervention indicated http://purl.obolibrary.org/obo/OAE_0003039 Grade 3 vasculitis AE http://purl.obolibrary.org/obo/OAE_0000565 vasculitis AE a vasculitis AE that shows severe symptoms, medical intervention indicated (e.g., steroids) http://purl.obolibrary.org/obo/OAE_0003040 Grade 4 vasculitis AE http://purl.obolibrary.org/obo/OAE_0000565 vasculitis AE a vasculitis AE that shows threatening; evidence of peripheral or visceral ischemia; urgent intervention indicated http://purl.obolibrary.org/obo/OAE_0003041 Grade 1 alopecia AE http://purl.obolibrary.org/obo/OAE_0000415 alopecia AE an alopecia AE that has hair loss of <50% of normal for that individual that is not obvious from a distance but only on close inspection; a different hair style may be required to cover the hair loss but it does not require a wig or hair piece to camouflage http://purl.obolibrary.org/obo/OAE_0003042 Grade 2 alopecia AE http://purl.obolibrary.org/obo/OAE_0000415 alopecia AE an alopecia AE that has hair loss of >=50% normal for that individual that is readily apparent to others; a wig or hair piece is necessary if the patient desires to completely camouflage the hair loss; associated with psychosocial impact http://purl.obolibrary.org/obo/OAE_0003043 Grade 1 dry skin AE http://purl.obolibrary.org/obo/OAE_0000894 dry skin AE a dry skin AE that is coverying <10% BSA and no associated erythema or pruritus http://purl.obolibrary.org/obo/OAE_0003044 Grade 2 dry skin AE http://purl.obolibrary.org/obo/OAE_0000894 dry skin AE a dry skin AE that is coverying 10 - 30% BSA and associated with erythema or pruritus; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0003045 Grade 3 dry skin AE http://purl.obolibrary.org/obo/OAE_0000894 dry skin AE a dry skin AE that is coverying >30% BSA and associated with pruritus; limiting self care ADL http://purl.obolibrary.org/obo/OAE_0003046 Grade 1 erythema multiforme AE http://purl.obolibrary.org/obo/OAE_0000449 erythema multiforme AE an erythema multiforme AE that has target lesions covering <10% BSA and not associated with skin tenderness http://purl.obolibrary.org/obo/OAE_0003047 Grade 2 erythema multiforme AE http://purl.obolibrary.org/obo/OAE_0000449 erythema multiforme AE an erythema multiforme AE that has target lesions covering 10 - 30% BSA and associated with skin tenderness http://purl.obolibrary.org/obo/OAE_0003048 Grade 3 erythema multiforme AE http://purl.obolibrary.org/obo/OAE_0000449 erythema multiforme AE an erythema multiforme AE that has target lesions covering >30% BSA and associated with oral or genital erosions http://purl.obolibrary.org/obo/OAE_0003049 Grade 4 erythema multiforme AE http://purl.obolibrary.org/obo/OAE_0000449 erythema multiforme AE an erythema multiforme AE that has target lesions covering >30% BSA; associated with fluid or electrolyte abnormalities; ICU care or burn unit indicated http://purl.obolibrary.org/obo/OAE_0003050 Grade 1 hyperhidrosis AE http://purl.obolibrary.org/obo/OAE_0001045 hyperhidrosis AE a hyperhidros AE that shows limited to one site (palms, soles, or axillae); self care interventions http://purl.obolibrary.org/obo/OAE_0003051 Grade 2 hyperhidrosis AE http://purl.obolibrary.org/obo/OAE_0001045 hyperhidrosis AE a hyperhidros AE that has Involving >1 site; patient seeks medical intervention; associated with psychosocial impact http://purl.obolibrary.org/obo/OAE_0003052 Grade 3 hyperhidrosis AE http://purl.obolibrary.org/obo/OAE_0001045 hyperhidrosis AE a hyperhidros AE that has Generalized involving sites other than palms, soles, or axillae; associated with electrolyte/hemodynamic imbalance http://purl.obolibrary.org/obo/OAE_0003053 Grade 1 palmar-plantar erythrodysesthesia syndrome AE http://purl.obolibrary.org/obo/OAE_0001271 palmar-plantar erythrodysesthesia syndrome AE a palmar-plantar erythrodysesthesia syndrome AE that has minimal skin changes or dermatitis (e.g., erythema, edema, or hyperkeratosis) without pain http://purl.obolibrary.org/obo/OAE_0003054 Grade 2 palmar-plantar erythrodysesthesia syndrome AE http://purl.obolibrary.org/obo/OAE_0001271 palmar-plantar erythrodysesthesia syndrome AE a palmar-plantar erythrodysesthesia syndrome AE that has skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0003055 Grade 3 palmar-plantar erythrodysesthesia syndrome AE http://purl.obolibrary.org/obo/OAE_0001271 palmar-plantar erythrodysesthesia syndrome AE a palmar-plantar erythrodysesthesia syndrome AE that has severe skin changes (e.g., peeling, blisters, bleeding, edema, or hyperkeratosis) with pain; limiting self care ADL http://purl.obolibrary.org/obo/OAE_0003056 Grade 1 periorbital edema AE http://purl.obolibrary.org/obo/OAE_0000681 periorbital edema AE a periorbital edema AE that has soft or non-pitting http://purl.obolibrary.org/obo/OAE_0003057 Grade 2 periorbital edema AE http://purl.obolibrary.org/obo/OAE_0000681 periorbital edema AE a periorbital edema AE that has indurated or pitting edema; topical intervention indicated http://purl.obolibrary.org/obo/OAE_0003058 Grade 3 periorbital edema AE http://purl.obolibrary.org/obo/OAE_0000681 periorbital edema AE a periorbital edema AE that has edema associated with visual disturbance; increased intraocular pressure, glaucoma or retinal hemorrhage; optic neuritis; diuretics indicated; operative intervention indicated http://purl.obolibrary.org/obo/OAE_0003059 Grade 1 photosensitivity AE http://purl.obolibrary.org/obo/OAE_0001295 photosensitivity reaction AE a photosensitivity reaction AE that has painless erythema and erythema covering <10% BSA http://purl.obolibrary.org/obo/OAE_0003060 Grade 2 photosensitivity AE http://purl.obolibrary.org/obo/OAE_0001295 photosensitivity reaction AE a photosensitivity reaction AE that has tender erythema covering 10 - 30% BSA http://purl.obolibrary.org/obo/OAE_0003061 Grade 3 photosensitivity AE http://purl.obolibrary.org/obo/OAE_0001295 photosensitivity reaction AE a photosensitivity reaction AE that has erythema covering >30% BSA and erythema with blistering; photosensitivity; oral corticosteroid therapy indicated; pain control indicated (e.g., narcotics or NSAIDs) http://purl.obolibrary.org/obo/OAE_0003062 Grade 1 pruritus AE http://purl.obolibrary.org/obo/OAE_0000373 pruritus AE a pruritus AE that has mild or localized; topical intervention indicated http://purl.obolibrary.org/obo/OAE_0003063 Grade 2 pruritus AE http://purl.obolibrary.org/obo/OAE_0000373 pruritus AE a pruritus AE that has intense or widespread; intermittent; skin changes from scratching (e.g., edema, papulation, excoriations, lichenification, oozing/crusts); oral intervention indicated; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0003064 Grade 3 pruritus AE http://purl.obolibrary.org/obo/OAE_0000373 pruritus AE a pruritus AE that has intense or widespread; constant; limiting self care ADL or sleep; oral corticosteroid or immunosuppressive therapy indicated http://purl.obolibrary.org/obo/OAE_0003065 Grade 1 purpura AE http://purl.obolibrary.org/obo/OAE_0000487 purpura AE a purpura AE that has combined area of lesions covering <10% BSA http://purl.obolibrary.org/obo/OAE_0003066 Grade 2 purpura AE http://purl.obolibrary.org/obo/OAE_0000487 purpura AE a purpura AE that has combined area of lesions covering 10 - 30% BSA; bleeding with trauma http://purl.obolibrary.org/obo/OAE_0003067 Grade 3 purpura AE http://purl.obolibrary.org/obo/OAE_0000487 purpura AE a purpura AE that has combined area of lesions covering >30% BSA; spontaneous bleeding http://purl.obolibrary.org/obo/OAE_0003068 Grade 1 skin atrophy AE http://purl.obolibrary.org/obo/OAE_0002547 skin atrophy AE a skin atrophy AE that has covering <10% BSA; associated with telangiectasias or changes in skin color http://purl.obolibrary.org/obo/OAE_0003069 Grade 2 skin atrophy AE http://purl.obolibrary.org/obo/OAE_0002547 skin atrophy AE a skin atrophy AE that has covering 10 - 30% BSA; associated with striae or adnexal structure loss http://purl.obolibrary.org/obo/OAE_0003070 Grade 3 skin atrophy AE http://purl.obolibrary.org/obo/OAE_0002547 skin atrophy AE a skin atrophy AE that has covering >30% BSA; associated with ulceration http://purl.obolibrary.org/obo/OAE_0003071 Grade 1 skin hyperpigmentation AE http://purl.obolibrary.org/obo/OAE_0001397 skin hyperpigmentation AE a skin hyperpigmentation AE that has hyperpigmentation covering <10% BSA; no psychosocial impact http://purl.obolibrary.org/obo/OAE_0003072 Grade 2 skin hyperpigmentation AE http://purl.obolibrary.org/obo/OAE_0001397 skin hyperpigmentation AE a skin hyperpigmentation AE that has hyperpigmentation covering >10% BSA; associated psychosocial impact http://purl.obolibrary.org/obo/OAE_0003073 Grade 1 skin hypopigmentation AE http://purl.obolibrary.org/obo/OAE_0002549 skin hypopigmentation AE a skin hypopigmentation AE that has hypopigmentation or depigmentation covering <10% BSA; no psychosocial impact http://purl.obolibrary.org/obo/OAE_0003074 Grade 2 skin hypopigmentation AE http://purl.obolibrary.org/obo/OAE_0002549 skin hypopigmentation AE a skin hypopigmentation AE that has hypopigmentation or depigmentation covering >10% BSA; associated psychosocial impact http://purl.obolibrary.org/obo/OAE_0003075 Grade 3 stevens-Johnson syndrome AE http://purl.obolibrary.org/obo/OAE_0001425 stevens-johnson syndrome AE a stevens-johnson syndrome AE that has skin sloughing covering <10% BSA with associated signs (e.g., erythema, purpura, epidermal detachment and mucous membrane detachment) http://purl.obolibrary.org/obo/OAE_0003076 Grade 4 stevens-Johnson syndrome AE http://purl.obolibrary.org/obo/OAE_0001425 stevens-johnson syndrome AE a stevens-johnson syndrome AE that has skin sloughing covering 10 - 30% BSA with associated signs (e.g., erythema, purpura, epidermal detachment and mucous membrane detachment) http://purl.obolibrary.org/obo/OAE_0003077 Grade 1 telangiectasia AE http://purl.obolibrary.org/obo/OAE_0002564 telangiectasia AE a telangiectasia AE that has telangiectasias covering <10% BSA http://purl.obolibrary.org/obo/OAE_0003078 Grade 2 telangiectasia AE http://purl.obolibrary.org/obo/OAE_0002564 telangiectasia AE a telangiectasia AE that has telangiectasias covering >10% BSA; associated with psychosocial impact http://purl.obolibrary.org/obo/OAE_0003079 Grade 4 toxic epidermal necrolysis AE http://purl.obolibrary.org/obo/OAE_0001993 toxic epidermal necrolysis AE a toxic epidermal necrolysis AE that has skin sloughing covering >=30% BSA with associated symptoms (e.g., erythema, purpura, or epidermal detachment) http://purl.obolibrary.org/obo/OAE_0003080 Grade 1 urticaria AE http://purl.obolibrary.org/obo/OAE_0000376 urticaria AE an urticaria AE that has urticarial lesions covering <10% BSA; topical intervention indicated http://purl.obolibrary.org/obo/OAE_0003081 Grade 2 urticaria AE http://purl.obolibrary.org/obo/OAE_0000376 urticaria AE an urticaria AE that has urticarial lesions covering 10 - 30% BSA; oral intervention indicated http://purl.obolibrary.org/obo/OAE_0003082 Grade 3 urticaria AE http://purl.obolibrary.org/obo/OAE_0000376 urticaria AE an urticaria AE that has urticariallesions covering >30% BSA; IV intervention indicated http://purl.obolibrary.org/obo/OAE_0003083 Grade 2 aspiration AE http://purl.obolibrary.org/obo/OAE_0000666 aspiration AE an aspiration AE that has altered eating habits; coughing or choking episodes after eating or swallowing; medical intervention indicated (e.g., suction or oxygen) http://purl.obolibrary.org/obo/OAE_0003084 Grade 3 aspiration AE http://purl.obolibrary.org/obo/OAE_0000666 aspiration AE an aspiration AE that has dyspnea and pneumonia symptoms (e.g., aspiration pneumonia); hospitalization indicated; unable to aliment orally http://purl.obolibrary.org/obo/OAE_0003085 Grade 2 atelectasis AE http://purl.obolibrary.org/obo/OAE_0000674 atelectasis AE an atelectasis AE that has symptomatic (e.g., dyspnea, cough); medical intervention indicated (e.g., chest physiotherapy, suctioning); bronchoscopic suctioning http://purl.obolibrary.org/obo/OAE_0003086 Grade 3 atelectasis AE http://purl.obolibrary.org/obo/OAE_0000674 atelectasis AE an atelectasis AE that has oxygen indicated; hospitalization or elective operative intervention indicated (e.g., stent, laser) http://purl.obolibrary.org/obo/OAE_0003087 Grade 2 chylothorax AE http://purl.obolibrary.org/obo/OAE_0000820 chylothorax AE a chylothorax AE that has symptomatic; thoracentesis or tube drainage indicated http://purl.obolibrary.org/obo/OAE_0003088 Grade 3 chylothorax AE http://purl.obolibrary.org/obo/OAE_0000820 chylothorax AE a chylothorax AE that has severe symptoms; elective operative intervention indicated http://purl.obolibrary.org/obo/OAE_0003089 Grade 2 epistaxis AE http://purl.obolibrary.org/obo/OAE_0000508 epistaxis AE an epistaxis AE that has moderate symptoms; medical intervention indicated (e.g., nasal packing, cauterization; topical vasoconstrictors) http://purl.obolibrary.org/obo/OAE_0003090 Grade 3 hiccups AE http://purl.obolibrary.org/obo/OAE_0002671 Hiccups AE a Hiccups AE that has interfering with sleep; limiting self care ADL http://purl.obolibrary.org/obo/OAE_0003091 Grade 1 hoarseness AE http://purl.obolibrary.org/obo/OAE_0001928 hoarseness AE a hoarseness AE that has mild or intermittent voice change; fully understandable; self-resolves http://purl.obolibrary.org/obo/OAE_0003092 Grade 2 hoarseness AE http://purl.obolibrary.org/obo/OAE_0001928 hoarseness AE a hoarseness AE that has Moderate or persistent voice changes; may require occasional repetition but understandable on telephone; medical evaluation indicated http://purl.obolibrary.org/obo/OAE_0003093 Grade 3 hoarseness AE http://purl.obolibrary.org/obo/OAE_0001928 hoarseness AE a hoarseness AE that has severe voice changes including predominantly whispered speech http://purl.obolibrary.org/obo/OAE_0003094 Grade 2 hypoxia AE http://purl.obolibrary.org/obo/OAE_0000617 hypoxia AE a hypoxia AE that has decreased oxygen saturation with exercise (e.g., pulse oximeter <88%); intermittent supplemental oxygen http://purl.obolibrary.org/obo/OAE_0003095 Grade 3 hypoxia AE http://purl.obolibrary.org/obo/OAE_0000617 hypoxia AE a hypoxia AE that has decreased oxygen saturation at rest (e.g., pulse oximeter <88% or PaO2 <=55 mm Hg) http://purl.obolibrary.org/obo/OAE_0003096 Grade 4 hypoxia AE http://purl.obolibrary.org/obo/OAE_0000617 hypoxia AE a hypoxia AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) http://purl.obolibrary.org/obo/OAE_0003097 Grade 3 laryngeal edema AE http://purl.obolibrary.org/obo/OAE_0002241 laryngeal edema AE a laryngeal edema AE that has stridor; respiratory distress; hospitalization indicated http://purl.obolibrary.org/obo/OAE_0003098 Grade 4 laryngeal edema AE http://purl.obolibrary.org/obo/OAE_0002241 laryngeal edema AE a laryngeal edema AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) http://purl.obolibrary.org/obo/OAE_0003099 Grade 2 pleural effusion AE http://purl.obolibrary.org/obo/OAE_0001298 pleural effusion AE a pleural effusion AE that has symptomatic; intervention indicated (e.g., diuretics or limited therapeutic thoracentesis) http://purl.obolibrary.org/obo/OAE_0003100 Grade 3 pleural effusion AE http://purl.obolibrary.org/obo/OAE_0001298 pleural effusion AE a pleural effusion AE that has symptomatic with respiratory distress and hypoxia; surgical intervention including chest tube or pleurodesis indicated http://purl.obolibrary.org/obo/OAE_0003101 Grade 1 pleural hemorrhage AE http://purl.obolibrary.org/obo/OAE_0001299 pleural hemorrhage AE a pleural hemorrhage AE that has asymptomatic; mild hemorrhage confirmed by thoracentesis http://purl.obolibrary.org/obo/OAE_0003102 Grade 2 pleural hemorrhage AE http://purl.obolibrary.org/obo/OAE_0001299 pleural hemorrhage AE a pleural hemorrhage AE that has symptomatic or associated with pneumothorax; chest tube drainage indicated http://purl.obolibrary.org/obo/OAE_0003103 Grade 3 pleural hemorrhage AE http://purl.obolibrary.org/obo/OAE_0001299 pleural hemorrhage AE a pleural hemorrhage AE that has >1000 ml of blood evacuated; persistent bleeding (150-200 ml/hr for 2 - 4 hr); persistent transfusion indicated; elective operative intervention indicated http://purl.obolibrary.org/obo/OAE_0003104 Grade 3 pneumonitis AE http://purl.obolibrary.org/obo/OAE_0001307 pneumonitis AE a pneumonitis AE that has severe symptoms; limiting self care ADL; oxygen indicated http://purl.obolibrary.org/obo/OAE_0003105 Grade 4 pneumonitis AE http://purl.obolibrary.org/obo/OAE_0001307 pneumonitis AE a pneumonitis AE that has life-threatening respiratory compromise; urgent intervention indicated (e.g., tracheotomy or intubation) http://purl.obolibrary.org/obo/OAE_0003106 Grade 2 pneumothorax AE http://purl.obolibrary.org/obo/OAE_0001308 pneumothorax AE a pneumothorax AE that has symptomatic; intervention indicated (e.g., tube placement without sclerosis) http://purl.obolibrary.org/obo/OAE_0003107 Grade 3 pneumothorax AE http://purl.obolibrary.org/obo/OAE_0001308 pneumothorax AE a pneumothorax AE that has sclerosis and/or operative intervention indicated; hospitalization indicated http://purl.obolibrary.org/obo/OAE_0003108 Grade 1 productive cough AE http://purl.obolibrary.org/obo/OAE_0001326 productive cough AE a productive cough AE that has occasional/minimal production of sputum with cough http://purl.obolibrary.org/obo/OAE_0003109 Grade 2 productive cough AE http://purl.obolibrary.org/obo/OAE_0001326 productive cough AE a productive cough AE that has moderate sputum production; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0003110 Grade 3 productive cough AE http://purl.obolibrary.org/obo/OAE_0001326 productive cough AE a productive cough AE that has persistent or copious production of sputum; limiting self care ADL http://purl.obolibrary.org/obo/OAE_0003111 Grade 1 pulmonary edema AE http://purl.obolibrary.org/obo/OAE_0001345 pulmonary edema AE a pulmonary edema AE that has radiologic findings only; minimal dyspnea on exertion http://purl.obolibrary.org/obo/OAE_0003112 Grade 2 pulmonary edema AE http://purl.obolibrary.org/obo/OAE_0001345 pulmonary edema AE a pulmonary edema AE that has moderate dyspnea on exertion; medical intervention indicated; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0003113 Grade 3 pulmonary edema AE http://purl.obolibrary.org/obo/OAE_0001345 pulmonary edema AE a pulmonary edema AE that has severe dyspnea or dyspnea at rest; oxygen indicated; limiting self care ADL http://purl.obolibrary.org/obo/OAE_0003114 Grade 4 pulmonary edema AE http://purl.obolibrary.org/obo/OAE_0001345 pulmonary edema AE a pulmonary edema AE that has life-threatening respiratory compromise; urgent intervention or intubation with ventilatory support indicated http://purl.obolibrary.org/obo/OAE_0003115 Grade 1 pulmonary fibrosis AE http://purl.obolibrary.org/obo/OAE_0001341 pulmonary fibrosis AE a pulmonary fibrosis AE that has mild hypoxemia; radiologic pulmonary fibrosis <25% of lung volume http://purl.obolibrary.org/obo/OAE_0003116 Grade 2 pulmonary fibrosis AE http://purl.obolibrary.org/obo/OAE_0001341 pulmonary fibrosis AE a pulmonary fibrosis AE that has moderate hypoxemia; evidence of pulmonary hypertension; radiographic pulmonary fibrosis 25 - 50% http://purl.obolibrary.org/obo/OAE_0003117 Grade 3 pulmonary fibrosis AE http://purl.obolibrary.org/obo/OAE_0001341 pulmonary fibrosis AE a pulmonary fibrosis AE that has severe hypoxemia; evidence of right-sided heart failure; radiographic pulmonary fibrosis >50 - 75% http://purl.obolibrary.org/obo/OAE_0003118 Grade 4 pulmonary fibrosis AE http://purl.obolibrary.org/obo/OAE_0001341 pulmonary fibrosis AE a pulmonary fibrosis AE that has life-threatening consequences (e.g., hemodynamic/pulmonary complications); intubation with ventilatory support indicated; radiographic pulmonary fibrosis >75% with severe honeycombing http://purl.obolibrary.org/obo/OAE_0003119 Grade 1 pulmonary hypertension AE http://purl.obolibrary.org/obo/OAE_0001343 pulmonary hypertension AE a pulmonary hypertension AE that has minimal dyspnea; findings on physical exam or other evaluation http://purl.obolibrary.org/obo/OAE_0003120 Grade 2 pulmonary hypertension AE http://purl.obolibrary.org/obo/OAE_0001343 pulmonary hypertension AE a pulmonary hypertension AE that has moderate dyspnea, cough; requiring evaluation by cardiac catheterization and medical intervention http://purl.obolibrary.org/obo/OAE_0003121 Grade 3 pulmonary hypertension AE http://purl.obolibrary.org/obo/OAE_0001343 pulmonary hypertension AE a pulmonary hypertension AE that has severe symptoms, associated with hypoxemia, right heart failure; oxygen indicated http://purl.obolibrary.org/obo/OAE_0003122 Grade 4 pulmonary hypertension AE http://purl.obolibrary.org/obo/OAE_0001343 pulmonary hypertension AE a pulmonary hypertension AE that has life-threatening airway consequences; urgent intervention indicated (e.g., tracheotomy or intubation) http://purl.obolibrary.org/obo/OAE_0003123 Grade 1 sinus disorder AE http://purl.obolibrary.org/obo/OAE_0001392 sinus disorder AE a sinus disorder AE that has asymptomatic mucosal crusting; blood-tinged secretions http://purl.obolibrary.org/obo/OAE_0003124 Grade 2 sinus disorder AE http://purl.obolibrary.org/obo/OAE_0001392 sinus disorder AE a sinus disorder AE that has symptomatic stenosis or edema/narrowing interfering with airflow; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0003125 Grade 3 sinus disorder AE http://purl.obolibrary.org/obo/OAE_0001392 sinus disorder AE a sinus disorder AE that has stenosis with significant nasal obstruction; limiting self care ADL http://purl.obolibrary.org/obo/OAE_0003126 Grade 4 sinus disorder AE http://purl.obolibrary.org/obo/OAE_0001392 sinus disorder AE a sinus disorder AE that has necrosis of soft tissue or bone; urgent operative intervention indicated http://purl.obolibrary.org/obo/OAE_0003127 Grade 3 sore throat AE http://purl.obolibrary.org/obo/OAE_0000538 sore throat AE a sore throat AE that has Severe pain; limiting self care ADL; limiting ability to swallow http://purl.obolibrary.org/obo/OAE_0003128 Grade 3 stridor AE http://purl.obolibrary.org/obo/OAE_0000690 stridor AE a stridor AE that has respiratory distress limiting self care ADL; medical intervention indicated http://purl.obolibrary.org/obo/OAE_0003129 Grade 4 stridor AE http://purl.obolibrary.org/obo/OAE_0000690 stridor AE a stridor AE that has life-threatening airway compromise; urgent intervention indicated (e.g., tracheotomy or intubation) http://purl.obolibrary.org/obo/OAE_0003130 Grade 1 voice alteration AE http://purl.obolibrary.org/obo/OAE_0000484 voice alteration AE a voice alteration AE that has mild or intermittent change from normal voice http://purl.obolibrary.org/obo/OAE_0003131 Grade 2 voice alteration AE http://purl.obolibrary.org/obo/OAE_0000484 voice alteration AE a voice alteration AE that has moderate or persistent change from normal voice; still understandable http://purl.obolibrary.org/obo/OAE_0003132 Grade 3 voice alteration AE http://purl.obolibrary.org/obo/OAE_0000484 voice alteration AE a voice alteration AE that has severe voice changes including predominantly whispered speech; may require frequent repetition or face-to-face contact for understandability; may require assistive technology http://purl.obolibrary.org/obo/OAE_0003133 Grade 1 wheezing AE http://purl.obolibrary.org/obo/OAE_0000053 wheezing AE a wheezing AE that has detectable airway noise with minimal symptoms http://purl.obolibrary.org/obo/OAE_0003134 Grade 3 wheezing AE http://purl.obolibrary.org/obo/OAE_0000053 wheezing AE a wheezing AE that has severe respiratory symptoms limiting self care ADL; oxygen therapy or hospitalization indicated http://purl.obolibrary.org/obo/OAE_0003135 Grade 2 menorrhagia AE http://purl.obolibrary.org/obo/OAE_0001170 menorrhagia AE a menorrhagia AE that has moderate symptoms; medical intervention indicated (e.g., hormones) http://purl.obolibrary.org/obo/OAE_0003136 Grade 3 menorrhagia AE http://purl.obolibrary.org/obo/OAE_0001170 menorrhagia AE a menorrhagia AE that has severe; transfusion indicated; surgical intervention indicated (e.g., hysterectomy) http://purl.obolibrary.org/obo/OAE_0003137 Grade 1 acute kidney injury AE http://purl.obolibrary.org/obo/OAE_0001365 acute kidney injury AE an acute kidney injury AE that has creatinine level increase of >0.3 mg/dL; creatinine 1.5 - 2.0 x above baseline http://purl.obolibrary.org/obo/OAE_0003138 Grade 2 acute kidney injury AE http://purl.obolibrary.org/obo/OAE_0001365 acute kidney injury AE an acute kidney injury AE that has creatinine 2 - 3 x above baseline http://purl.obolibrary.org/obo/OAE_0003139 Grade 3 acute kidney injury AE http://purl.obolibrary.org/obo/OAE_0001365 acute kidney injury AE an acute kidney injury AE that has creatinine >3 x baseline or >4.0 mg/dL; hospitalization indicated http://purl.obolibrary.org/obo/OAE_0003140 Grade 2 hematuria AE http://purl.obolibrary.org/obo/OAE_0000619 hematuria AE a hematuria AE that has symptomatic; urinary catheter or bladder irrigation indicated; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0003141 Grade 3 hematuria AE http://purl.obolibrary.org/obo/OAE_0000619 hematuria AE a hematuria AE that has gross hematuria; transfusion, IV medications or hospitalization indicated; elective endoscopic, radiologic or operative intervention indicated; limiting self care ADL http://purl.obolibrary.org/obo/OAE_0003142 Grade 1 urinary incontinence AE http://purl.obolibrary.org/obo/OAE_0000604 urinary incontinence AE an urinary incontinence AE that has occasional (e.g., with coughing, sneezing, etc.), pads not indicated http://purl.obolibrary.org/obo/OAE_0003143 Grade 2 urinary incontinence AE http://purl.obolibrary.org/obo/OAE_0000604 urinary incontinence AE an urinary incontinence AE that has spontaneous; pads indicated; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0003144 Grade 3 urinary incontinence AE http://purl.obolibrary.org/obo/OAE_0000604 urinary incontinence AE an urinary incontinence AE that has Intervention indicated (e.g., clamp, collagen injections); operative intervention indicated; limiting self care ADL http://purl.obolibrary.org/obo/OAE_0003145 Grade 1 urinary retention AE http://purl.obolibrary.org/obo/OAE_0001489 urinary retention AE an urinary retention AE that has urinary, suprapubic or intermittent catheter placement not indicated; able to void with some residual http://purl.obolibrary.org/obo/OAE_0003146 Grade 2 urinary retention AE http://purl.obolibrary.org/obo/OAE_0001489 urinary retention AE an urinary retention AE that has placement of urinary, suprapubic or intermittent catheter placement indicated; medication indicated http://purl.obolibrary.org/obo/OAE_0003147 Grade 3 urinary retention AE http://purl.obolibrary.org/obo/OAE_0001489 urinary retention AE an urinary retention AE that has elective operative or radiologic intervention indicated; substantial loss of affected kidney function or mass http://purl.obolibrary.org/obo/OAE_0003148 Grade 1 suicidal ideation AE http://purl.obolibrary.org/obo/OAE_0001432 suicidal ideation AE a suicidal ideation AE that has increased thoughts of death but no wish to kill oneself http://purl.obolibrary.org/obo/OAE_0003149 Grade 2 suicidal ideation AE http://purl.obolibrary.org/obo/OAE_0001432 suicidal ideation AE a suicidal ideation AE that has suicidal ideation with no specific plan or intent http://purl.obolibrary.org/obo/OAE_0003150 Grade 3 suicidal ideation AE http://purl.obolibrary.org/obo/OAE_0001432 suicidal ideation AE a suicidal ideation AE that has specific plan to commit suicide without serious intent to die which may not require hospitalization http://purl.obolibrary.org/obo/OAE_0003151 Grade 4 suicidal ideation AE http://purl.obolibrary.org/obo/OAE_0001432 suicidal ideation AE a suicidal ideation AE that has specific plan to commit suicide with serious intent to die which requires hospitalization http://purl.obolibrary.org/obo/OAE_0003152 Grade 3 suicide attempt AE http://purl.obolibrary.org/obo/OAE_0001433 suicide attempt AE a suicide attempt AE that has suicide attempt or gesture without intent to die which may not require hospitalization http://purl.obolibrary.org/obo/OAE_0003153 Grade 4 suicide attempt AE http://purl.obolibrary.org/obo/OAE_0001433 suicide attempt AE a suicide attempt AE that has suicide attempt with intent to die which requires hospitalization http://purl.obolibrary.org/obo/OAE_0003154 Grade 3 aphonia AE http://purl.obolibrary.org/obo/OAE_0002080 aphonia AE an aphonia AE that has voicelessness; unable to speak http://purl.obolibrary.org/obo/OAE_0003155 Grade 1 depressed level of consciousness AE http://purl.obolibrary.org/obo/OAE_0000864 depressed level of consciousness AE a depressed level of consciousness AE that has decreased level of alertness http://purl.obolibrary.org/obo/OAE_0003156 Grade 2 depressed level of consciousness AE http://purl.obolibrary.org/obo/OAE_0000864 depressed level of consciousness AE a depressed level of consciousness AE that has Sedation; slow response to stimuli; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0003157 Grade 3 depressed level of consciousness AE http://purl.obolibrary.org/obo/OAE_0000864 depressed level of consciousness AE a depressed level of consciousness AE that is difficult to arouse http://purl.obolibrary.org/obo/OAE_0003158 Grade 1 dysgeusia AE http://purl.obolibrary.org/obo/OAE_0000308 dysgeusia AE a dysgenusia AE that has altered taste but no change in diet http://purl.obolibrary.org/obo/OAE_0003159 Grade 2 dysgeusia AE http://purl.obolibrary.org/obo/OAE_0000308 dysgeusia AE a dysgenusia AE that has altered taste with change in diet (e.g., oral supplements); noxious or unpleasant taste; loss of taste http://purl.obolibrary.org/obo/OAE_0003160 Grade 1 leukoencephalopathy AE http://purl.obolibrary.org/obo/OAE_0001128 leukoencephalopathy AE a leukoencephalopathy AE that has asymptomatic; small focal T2/FLAIR hyperintensities; involving periventricular white matter or <1/3 of susceptible areas of cerebrum +/- mild increase in subarachnoid space (SAS) and/or mild ventriculomegaly http://purl.obolibrary.org/obo/OAE_0003161 Grade 2 leukoencephalopathy AE http://purl.obolibrary.org/obo/OAE_0001128 leukoencephalopathy AE a leukoencephalopathy AE that has moderate symptoms; focal T2/FLAIR hyperintensities, involving periventricular white matter extending into centrum semiovale or involving 1/3 to 2/3 of susceptible areas of cerebrum +/- moderate increase in SAS and/or moderate ventriculomegaly http://purl.obolibrary.org/obo/OAE_0003162 Grade 3 leukoencephalopathy AE http://purl.obolibrary.org/obo/OAE_0001128 leukoencephalopathy AE a leukoencephalopathy AE that has severe symptoms; extensive T2/FLAIR hyperintensities, involving periventricular white matter involving 2/3 or more of susceptible areas of cerebrum +/- moderate to severe increase in SAS and/or moderate to severe ventriculomegaly http://purl.obolibrary.org/obo/OAE_0003163 Grade 4 leukoencephalopathy AE http://purl.obolibrary.org/obo/OAE_0001128 leukoencephalopathy AE a leukoencephalopathy AE that has life-threatening consequences; extensive T2/FLAIR hyperintensities, involving periventricular white matter involving most of susceptible areas of cerebrum +/- moderate to severe increase in SAS and/or moderate to severe ventriculomegaly http://purl.obolibrary.org/obo/OAE_0003164 Grade 1 myelitis AE http://purl.obolibrary.org/obo/OAE_0000478 myelitis AE a myelitis AE that has asymptomatic; mild signs (e.g., Babinski's reflex or Lhermitte's sign) http://purl.obolibrary.org/obo/OAE_0003165 Grade 2 myelitis AE http://purl.obolibrary.org/obo/OAE_0000478 myelitis AE a myelitis AE that has moderate weakness or sensory loss; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0003166 Grade 3 myelitis AE http://purl.obolibrary.org/obo/OAE_0000478 myelitis AE a myelitis AE that has severe weakness or sensory loss; limiting self care ADL http://purl.obolibrary.org/obo/OAE_0003167 Grade 2 presyncope AE http://purl.obolibrary.org/obo/OAE_0001319 presyncope AE a presyncope AE that has present (e.g., near fainting) http://purl.obolibrary.org/obo/OAE_0003168 Grade 1 seizure AE http://purl.obolibrary.org/obo/OAE_0000579 seizure AE a seizure AE that has brief partial seizure; no loss of consciousness http://purl.obolibrary.org/obo/OAE_0003169 Grade 2 seizure AE http://purl.obolibrary.org/obo/OAE_0000579 seizure AE a seizure AE that has brief generalized seizure http://purl.obolibrary.org/obo/OAE_0003170 Grade 3 seizure AE http://purl.obolibrary.org/obo/OAE_0000579 seizure AE a seizure AE that has multiple seizures despite medical intervention http://purl.obolibrary.org/obo/OAE_0003171 Grade 4 seizure AE http://purl.obolibrary.org/obo/OAE_0000579 seizure AE a seizure AE that has life-threatening; prolonged repetitive seizures http://purl.obolibrary.org/obo/OAE_0003172 Grade 1 somnolence AE http://purl.obolibrary.org/obo/OAE_0000391 somnolence AE a somnolence AE that has mild but more than usual drowsiness or sleepiness http://purl.obolibrary.org/obo/OAE_0003173 Grade 2 somnolence AE http://purl.obolibrary.org/obo/OAE_0000391 somnolence AE a somnolence AE that has moderate sedation; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0003174 Grade 3 somnolence AE http://purl.obolibrary.org/obo/OAE_0000391 somnolence AE a somnolence AE that has obtundation or stupor http://purl.obolibrary.org/obo/OAE_0003175 Grade 3 syncope AE http://purl.obolibrary.org/obo/OAE_0000400 syncope AE a syncope AE that has fainting; orthostatic collapse http://purl.obolibrary.org/obo/OAE_0003176 Grade 1 arthritis AE http://purl.obolibrary.org/obo/OAE_0000596 arthritis AE an arthritis AE that has mild pain with inflammation, erythema, or joint swelling http://purl.obolibrary.org/obo/OAE_0003177 Grade 2 arthritis AE http://purl.obolibrary.org/obo/OAE_0000596 arthritis AE an arthritis AE that has moderate pain associated with signs of inflammation, erythema, or joint swelling; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0003178 Grade 3 arthritis AE http://purl.obolibrary.org/obo/OAE_0000596 arthritis AE an arthritis AE that has severe pain associated with signs of inflammation, erythema, or joint swelling; irreversible joint damage; disabling; limiting self care ADL http://purl.obolibrary.org/obo/OAE_0003179 Grade 1 joint range of motion decreased AE http://purl.obolibrary.org/obo/OAE_0000676 joint range of motion decreased AE a joint range of motion decreased AE that requires <=25% loss of ROM (range of motion); decreased ROM limiting athletic activity http://purl.obolibrary.org/obo/OAE_0003180 Grade 2 joint range of motion decreased AE http://purl.obolibrary.org/obo/OAE_0000676 joint range of motion decreased AE a joint range of motion decreased AE that requires >25 - 50% decrease in ROM; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0003181 Grade 3 joint range of motion decreased AE http://purl.obolibrary.org/obo/OAE_0000676 joint range of motion decreased AE a joint range of motion decreased AE that requires >50% decrease in ROM; limiting self care ADL; disabling http://purl.obolibrary.org/obo/OAE_0003182 Grade 1 osteoporosis AE http://purl.obolibrary.org/obo/OAE_0001529 osteoporosis AE an osteoporosis AE that has radiologic evidence of osteoporosis or Bone Mineral Density (BMD) t-score -1 to -2.5 (osteopenia); no loss of height or intervention indicated http://purl.obolibrary.org/obo/OAE_0003183 Grade 2 osteoporosis AE http://purl.obolibrary.org/obo/OAE_0001529 osteoporosis AE an osteoporosis AE that has BMD t-score <-2.5; loss of height <2 cm; anti-osteoporotic therapy indicated; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0003184 Grade 3 osteoporosis AE http://purl.obolibrary.org/obo/OAE_0001529 osteoporosis AE an osteoporosis AE that has loss of height >=2 cm; hospitalization indicated; limiting self care ADL http://purl.obolibrary.org/obo/OAE_0003185 Grade 1 acidosis AE http://purl.obolibrary.org/obo/OAE_0002331 acidosis AE an acidosis AE that has pH =7.3 http://purl.obolibrary.org/obo/OAE_0003186 Grade 3 acidosis AE http://purl.obolibrary.org/obo/OAE_0002331 acidosis AE an acidosis AE that has pH <7.3 http://purl.obolibrary.org/obo/OAE_0003187 Grade 1 anorexia AE http://purl.obolibrary.org/obo/OAE_0000396 anorexia AE an anorexia AE that has loss of appetite without alteration in eating habits http://purl.obolibrary.org/obo/OAE_0003188 Grade 2 anorexia AE http://purl.obolibrary.org/obo/OAE_0000396 anorexia AE an anorexia AE that has oral intake altered without significant weight loss or malnutrition; oral nutritional supplements indicated http://purl.obolibrary.org/obo/OAE_0003189 Grade 3 anorexia AE http://purl.obolibrary.org/obo/OAE_0000396 anorexia AE an anorexia AE that has associated with significant weight loss or malnutrition (e.g., inadequate oral caloric and/or fluid intake); tube feeding or TPN indicated http://purl.obolibrary.org/obo/OAE_0003190 Grade 1 dehydration AE http://purl.obolibrary.org/obo/OAE_0000545 dehydration AE a dehydration AE that has increased oral fluids indicated; dry mucous membranes; diminished skin turgor http://purl.obolibrary.org/obo/OAE_0003191 Grade 2 dehydration AE http://purl.obolibrary.org/obo/OAE_0000545 dehydration AE a dehydration AE that requires IIV fluids indicated <24 hrs http://purl.obolibrary.org/obo/OAE_0003192 Grade 1 hypercalcemia AE http://purl.obolibrary.org/obo/OAE_0001044 hypercalcemia AE a hypercalcemia AE that has corrected serum calcium of >ULN - 11.5 mg/dL; >ULN - 2.9 mmol/L; Ionized calcium >ULN - 1.5 mmol/L http://purl.obolibrary.org/obo/OAE_0003193 Grade 2 hypercalcemia AE http://purl.obolibrary.org/obo/OAE_0001044 hypercalcemia AE a hypercalcemia AE that has corrected serum calcium of >11.5 - 12.5 mg/dL; >2.9 - 3.1 mmol/L; Ionized calcium >1.5 - 1.6 mmol/L; symptomatic http://purl.obolibrary.org/obo/OAE_0003194 Grade 3 hypercalcemia AE http://purl.obolibrary.org/obo/OAE_0001044 hypercalcemia AE a hypercalcemia AE that has corrected serum calcium of >12.5 - 13.5 mg/dL; >3.1 - 3.4 mmol/L; Ionized calcium >1.6 - 1.8 mmol/L; hospitalization indicated http://purl.obolibrary.org/obo/OAE_0003195 Grade 4 hypercalcemia AE http://purl.obolibrary.org/obo/OAE_0001044 hypercalcemia AE a hypercalcemia AE that has corrected serum calcium of >13.5 mg/dL; >3.4 mmol/L; Ionized calcium >1.8 mmol/L; life-threatening consequences http://purl.obolibrary.org/obo/OAE_0003196 Grade 1 hyperglycemia AE http://purl.obolibrary.org/obo/OAE_0000547 hyperglycemia AE a hypeglycemia AE that has fasting glucose value >ULN - 160 mg/dL; Fasting glucose value >ULN - 8.9 mmol/L http://purl.obolibrary.org/obo/OAE_0003197 Grade 2 hyperglycemia AE http://purl.obolibrary.org/obo/OAE_0000547 hyperglycemia AE a hypeglycemia AE that has fasting glucose value >160 - 250 mg/dL; Fasting glucose value >8.9 - 13.9 mmol/L http://purl.obolibrary.org/obo/OAE_0003198 Grade 3 hyperglycemia AE http://purl.obolibrary.org/obo/OAE_0000547 hyperglycemia AE a hypeglycemia AE that has >250 - 500 mg/dL; >13.9 - 27.8 mmol/L; hospitalization indicated http://purl.obolibrary.org/obo/OAE_0003199 Grade 4 hyperglycemia AE http://purl.obolibrary.org/obo/OAE_0000547 hyperglycemia AE a hypeglycemia AE that has >500 mg/dL; >27.8 mmol/L; life-threatening consequences http://purl.obolibrary.org/obo/OAE_0003200 Grade 1 hyperkalemia AE http://purl.obolibrary.org/obo/OAE_0001046 hyperkalemia AE a hyperkalemia AE that requires >ULN - 5.5 mmol/L http://purl.obolibrary.org/obo/OAE_0003201 Grade 2 hyperkalemia AE http://purl.obolibrary.org/obo/OAE_0001046 hyperkalemia AE a hyperkalemia AE that requires >5.5 - 6.0 mmol/L http://purl.obolibrary.org/obo/OAE_0003202 Grade 3 hyperkalemia AE http://purl.obolibrary.org/obo/OAE_0001046 hyperkalemia AE a hyperkalemia AE that requires >6.0 - 7.0 mmol/L; hospitalization indicated http://purl.obolibrary.org/obo/OAE_0003203 Grade 4 hyperkalemia AE http://purl.obolibrary.org/obo/OAE_0001046 hyperkalemia AE a hyperkalemia AE that requires >7.0 mmol/L; life-threatening consequences http://purl.obolibrary.org/obo/OAE_0003204 Grade 1 hypertriglyceridemia AE http://purl.obolibrary.org/obo/OAE_0001052 hypertriglyceridemia AE a hypertriglyceridemia AE that requires 150 mg/dL - 300 mg/dL; 1.71 mmol/L - 3.42 mmol/L http://purl.obolibrary.org/obo/OAE_0003205 Grade 2 hypertriglyceridemia AE http://purl.obolibrary.org/obo/OAE_0001052 hypertriglyceridemia AE a hypertriglyceridemia AE that requires >300 mg/dL - 500 mg/dL; >3.42 mmol/L - 5.7 mmol/L http://purl.obolibrary.org/obo/OAE_0003206 Grade 3 hypertriglyceridemia AE http://purl.obolibrary.org/obo/OAE_0001052 hypertriglyceridemia AE a hypertriglyceridemia AE that requires >500 mg/dL - 1000 mg/dL; >5.7 mmol/L - 11.4 mmol/L http://purl.obolibrary.org/obo/OAE_0003207 Grade 4 hypertriglyceridemia AE http://purl.obolibrary.org/obo/OAE_0001052 hypertriglyceridemia AE a hypertriglyceridemia AE that requires >1000 mg/dL; >11.4 mmol/L; life-threatening consequences http://purl.obolibrary.org/obo/OAE_0003208 Grade 1 hyperuricemia AE http://purl.obolibrary.org/obo/OAE_0001053 hyperuricemia AE a hyperuricemia AE that requires >ULN - 10 mg/dL (0.59 mmol/L) without physiologic consequences http://purl.obolibrary.org/obo/OAE_0003209 Grade 3 hyperuricemia AE http://purl.obolibrary.org/obo/OAE_0001053 hyperuricemia AE a hyperuricemia AE that requires >ULN - 10 mg/dL (0.59 mmol/L) with physiologic consequences http://purl.obolibrary.org/obo/OAE_0003210 Grade 4 hyperuricemia AE http://purl.obolibrary.org/obo/OAE_0001053 hyperuricemia AE a hyperuricemia AE that requires >10 mg/dL; >0.59 mmol/L; life-threatening consequences http://purl.obolibrary.org/obo/OAE_0003211 Grade 1 hypoalbuminemia AE http://purl.obolibrary.org/obo/OAE_0001054 hypoalbuminemia AE a hypoalbuminemia AE that requires NCI=7 stools per day over baseline; incontinence; hospitalization indicated; severe increase in ostomy output compared to baseline; limiting self care ADL http://purl.obolibrary.org/obo/VO_0000300 injection site http://purl.obolibrary.org/obo/OAE_0000227 medical intervention site a medical intervention site that is used for injection of a substance. http://purl.obolibrary.org/obo/UBERON_0000310 breast http://purl.obolibrary.org/obo/UBERON_0034929 external soft tissue zone The upper ventral region of an animal's torso. http://purl.obolibrary.org/obo/OAE_0002944 Grade 3 cystitis noninfective AE http://purl.obolibrary.org/obo/OAE_0002696 cystitis noninfective AE a cystitis noninfective AE that has gross hematuria; transfusion, IV medications or hospitalization indicated; elective endoscopic, radiologic or operative intervention indicated http://purl.obolibrary.org/obo/PATO_0001018 physical quality http://purl.obolibrary.org/obo/PATO_0001241 physical object quality A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities. http://purl.obolibrary.org/obo/PATO_0001236 process quality http://purl.obolibrary.org/obo/BFO_0000019 quality A quality which inheres in an process. http://purl.obolibrary.org/obo/PATO_0001241 physical object quality http://purl.obolibrary.org/obo/BFO_0000019 quality A quality which inheres in a continuant. http://purl.obolibrary.org/obo/UBERON_0000004 nose http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure The olfactory organ of vertebrates, consisting of nares, olfactory epithelia and the structures and skeletal framework of the nasal cavity. http://purl.obolibrary.org/obo/UBERON_0000017 exocrine pancreas http://purl.obolibrary.org/obo/UBERON_0005177 trunk region element The part of the pancreas that is part of the exocrine system and which produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells [GO]. http://purl.obolibrary.org/obo/UBERON_0000033 head http://purl.obolibrary.org/obo/UBERON_0011676 subdivision of organism along main body axis The head is the anterior-most division of the body [GO]. http://purl.obolibrary.org/obo/UBERON_0000057 urethra http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure the fibromuscular tubular canal through which urine is discharged from the bladder to the exterior via the external urinary meatus; in males, the urethra is joined by the ejaculatory ducts and serves as a passageway for semen during ejaculation, as well as a canal for urine during voiding; in females, the urethra is shorter and emerges above the vaginal opening http://purl.obolibrary.org/obo/UBERON_0000079 male reproductive system http://purl.obolibrary.org/obo/UBERON_0000990 reproductive system The organs associated with producing offspring in the gender that produces spermatozoa. http://purl.obolibrary.org/obo/UBERON_0000474 female reproductive system http://purl.obolibrary.org/obo/UBERON_0000990 reproductive system The organs and associated structures associated with bearing offspring in a female animal. http://purl.obolibrary.org/obo/UBERON_0000915 thoracic segment of trunk http://purl.obolibrary.org/obo/UBERON_0011676 subdivision of organism along main body axis Subdivision of trunk that lies between the head and the abdomen. http://purl.obolibrary.org/obo/UBERON_0000947 aorta http://purl.obolibrary.org/obo/UBERON_0013768 great vessel of heart The main trunk of the systemic arterial system that carries blood from the heart to all the organs and other structures of the body, bringing oxygenated blood to all parts of the body in the systemic circulation http://purl.obolibrary.org/obo/UBERON_0000974 neck http://purl.obolibrary.org/obo/UBERON_0000475 organism subdivision An organism subdivision that extends from the head to the pectoral girdle, encompassing the cervical vertebral column. http://purl.obolibrary.org/obo/UBERON_0000991 gonad http://purl.obolibrary.org/obo/UBERON_0003133 reproductive organ Reproductive organ that produces and releases eggs (ovary) or sperm (testis). http://purl.obolibrary.org/obo/UBERON_0001003 skin epidermis http://purl.obolibrary.org/obo/UBERON_3000961 external integument structure The outer epithelial layer of the skin that is superficial to the dermis. http://purl.obolibrary.org/obo/UBERON_0001007 digestive system http://purl.obolibrary.org/obo/UBERON_0000467 anatomical system Anatomical system that has as its parts the organs devoted to the ingestion, digestion, and assimilation of food and the discharge of residual wastes. http://purl.obolibrary.org/obo/UBERON_0001008 renal system http://purl.obolibrary.org/obo/UBERON_0000467 anatomical system The renal system in an anatomical system that maintains fluid balance and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products.. http://purl.obolibrary.org/obo/UBERON_0001135 smooth muscle tissue http://purl.obolibrary.org/obo/UBERON_0002385 muscle tissue Muscle tissue which is unstriated, composed primarily of smooth muscle fibers surrounded by a reticulum of collagen and elastic fibers. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length[GO]. http://purl.obolibrary.org/obo/UBERON_0001156 ascending colon http://purl.obolibrary.org/obo/UBERON_0000168 proximal-distal subdivision of colon Section of colon which is distal to the cecum and proximal to the transversecolon.[FMA,modified] http://purl.obolibrary.org/obo/UBERON_0001157 transverse colon http://purl.obolibrary.org/obo/UBERON_0000168 proximal-distal subdivision of colon The proximal-distal subdivision of colon that runs transversely across the upper part of the abdomen, from the right to the left colic flexure. Continuous with the descending colon[BTO,modified]. http://purl.obolibrary.org/obo/UBERON_0001161 body of stomach http://purl.obolibrary.org/obo/UBERON_0009870 zone of stomach The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined[GO]. http://purl.obolibrary.org/obo/UBERON_0001173 biliary tree http://purl.obolibrary.org/obo/UBERON_0013765 digestive system element A complex network of conduits that begins with the canals of Hering (intralobar bile duct) and progressively merges into a system of interlobular, septal, and major ducts which then coalesce to form the extrahepatic bile ducts, which finally deliver bile to the intestine, and in some species to the gallbladder. http://purl.obolibrary.org/obo/UBERON_0001174 common bile duct http://purl.obolibrary.org/obo/UBERON_0003703 extrahepatic bile duct the part of the biliary tree formed by the union of the cystic duct and the common hepatic duct http://purl.obolibrary.org/obo/UBERON_0001224 renal pelvis http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure A funnel shaped proximal portion of the ureter that is formed by convergence of the major calices [MP]. http://purl.obolibrary.org/obo/UBERON_0001264 pancreas http://purl.obolibrary.org/obo/UBERON_0002075 viscus An endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes[GO]. http://purl.obolibrary.org/obo/UBERON_0001456 face http://purl.obolibrary.org/obo/UBERON_0001444 subdivision of head A subdivision of the head that has as parts the layers deep to the surface of the anterior surface, including the mouth, eyes, and nose (when present). In vertebrates, this includes the facial skeleton and structures superficial to the facial skeleton (cheeks, mouth, eyeballs, skin of face, etc). http://purl.obolibrary.org/obo/UBERON_0001557 upper respiratory tract http://purl.obolibrary.org/obo/UBERON_0000072 proximo-distal subdivision of respiratory tract The segment of the respiratory tract that starts proximally with the nose and ends distally with the cricoid cartilage, before continuing to the trachea. http://purl.obolibrary.org/obo/UBERON_0001621 coronary artery http://purl.obolibrary.org/obo/UBERON_0004573 systemic artery An artery that supplies the myocardium. http://purl.obolibrary.org/obo/UBERON_0001638 vein http://purl.obolibrary.org/obo/UBERON_0003920 venous blood vessel Any of the tubular branching vessels that carry blood from the capillaries toward the heart. http://purl.obolibrary.org/obo/UBERON_0001768 uvea http://purl.obolibrary.org/obo/UBERON_0010314 structure with developmental contribution from neural crest the pigmented middle of the three concentric layers that make up an eye, consisting of the iris, ciliary body and choroid[WP,edited]. http://purl.obolibrary.org/obo/UBERON_0001769 iris http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye http://purl.obolibrary.org/obo/UBERON_0001775 ciliary body http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure the thickened portion of the vascular tunic, which lies between the choroid and the iris, composed of ciliary muscle and ciliary processes http://purl.obolibrary.org/obo/UBERON_0001785 cranial nerve http://purl.obolibrary.org/obo/UBERON_0034713 cranial neuron projection bundle Cranial nerves are nerves that emerge directly from the brain, in contrast to spinal nerves, which emerge from segments of the spinal cord. http://purl.obolibrary.org/obo/UBERON_0001893 telencephalon http://purl.obolibrary.org/obo/UBERON_0010314 structure with developmental contribution from neural crest Part of the forebrain consisting of paired olfactory bulbs and cerebral hemispheres. http://purl.obolibrary.org/obo/UBERON_0002037 cerebellum http://purl.obolibrary.org/obo/UBERON_0010314 structure with developmental contribution from neural crest Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement[MESH]. A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe[BTO]. Brain structure derived from the anterior hindbrain, and perhaps including posterior midbrain. The cerebellum plays a role in somatic motor function, the control of muscle tone, and balance[ZFA]. http://purl.obolibrary.org/obo/UBERON_0002067 dermis http://purl.obolibrary.org/obo/UBERON_0013754 integumentary system layer The dermis is a layer of skin between the epidermis (with which it makes up the skin) and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis[WP]. http://purl.obolibrary.org/obo/UBERON_0002349 myocardium http://purl.obolibrary.org/obo/UBERON_0018260 layer of muscle tissue the middle layer of the heart, comprised mainly of striated cardiac muscle fibers http://purl.obolibrary.org/obo/UBERON_0002371 bone marrow http://purl.obolibrary.org/obo/UBERON_0012429 hemopoietic tissue the soft tissue that fills the cavities of bones http://purl.obolibrary.org/obo/UBERON_0002385 muscle tissue http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]. http://purl.obolibrary.org/obo/UBERON_0002390 hematopoietic system http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure Anatomical system that is involved in the production of hematopoietic cells. http://purl.obolibrary.org/obo/UBERON_0002495 long bone http://purl.obolibrary.org/obo/UBERON_0001474 bone element Long bone is a limb bone that is subcylindrical and has a shaft with periosteum separating the ends of the bones. Long bones are present only in the limbs[VSAO:wd]. http://purl.obolibrary.org/obo/UBERON_0003074 mesonephric duct http://purl.obolibrary.org/obo/UBERON_0009201 nephric duct Paired organ that connects the primitive kidney Wolffian body (or mesonephros) to the cloaca and serves as the anlage for certain male reproductive organs. the Wolffian duct is what remains of the pronephric duct after the atrophy of the pronephros[WP]. In Zebrafish: Duct of the adult kidney (mesonephros), present bilaterally ventral to the somites and leading to the cloacal chamber[ZFA]. http://purl.obolibrary.org/obo/UBERON_0003704 intrahepatic bile duct http://purl.obolibrary.org/obo/UBERON_0002394 bile duct Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct. http://purl.obolibrary.org/obo/UBERON_0007329 pancreatic duct http://purl.obolibrary.org/obo/UBERON_0004119 endoderm-derived structure A duct that is part of the pancreas and connected to the duodenum. http://purl.obolibrary.org/obo/UBERON_0007616 layer of synovial tissue http://purl.obolibrary.org/obo/UBERON_0000042 serous membrane A thin, loose vascular connective tissue that makes up the membranes surrounding joints and the sheaths protecting tendons (particularly flexor tendons in the hands and feet) where they pass over bony prominences. Synovial tissue contains synovial cells, which secrete a viscous liquid called synovial fluid; this liquid contains protein and hyaluronic acid and serves as a lubricant and nutrient for the joint cartilage surfaces[BTO]. Synovial tissue can be found in tendons (tissues that connect muscle to bone), bursae (fluid-filled, cushioning sacs found in spaces between tendons, ligaments, and bones), and the cavity (hollow enclosed area) that separates the bones of a freely movable joint, such as the knee or elbow[BTO]. http://purl.obolibrary.org/obo/UBERON_0007798 vascular system http://purl.obolibrary.org/obo/UBERON_0000467 anatomical system Anatomical system that consists of all blood and lymph vessels. http://purl.obolibrary.org/obo/UBERON_0010743 meningeal cluster http://purl.obolibrary.org/obo/UBERON_0034925 anatomical collection The collection of all meningeal layers that line a central nervous system. http://purl.obolibrary.org/obo/UBERON_0018707 bladder organ http://purl.obolibrary.org/obo/UBERON_0009856 sac A membranous sac in animals that serves as the receptacle of a liquid or contains gas. http://purl.obolibrary.org/obo/BFO_0000002 continuant http://purl.obolibrary.org/obo/BFO_0000001 entity An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts. http://purl.obolibrary.org/obo/BFO_0000003 occurrent http://purl.obolibrary.org/obo/BFO_0000001 entity An entity that has temporal parts and that happens, unfolds or develops through time. http://purl.obolibrary.org/obo/BFO_0000004 independent continuant http://purl.obolibrary.org/obo/BFO_0000002 continuant A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything. http://purl.obolibrary.org/obo/BFO_0000015 process http://purl.obolibrary.org/obo/BFO_0000003 occurrent An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. http://purl.obolibrary.org/obo/BFO_0000020 specifically dependent continuant http://purl.obolibrary.org/obo/BFO_0000002 continuant A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same. http://purl.obolibrary.org/obo/OBI_0000011 planned process http://purl.obolibrary.org/obo/BFO_0000015 process A processual entity that realizes a plan which is the concretization of a plan specification. http://purl.obolibrary.org/obo/PATO_0000186 behavioral quality http://purl.obolibrary.org/obo/PATO_0001995 organismal quality An organismal quality inhering in a bearer by virtue of the bearer's behavior aggregate of the responses or reactions or movements in a given situation. http://purl.obolibrary.org/obo/PATO_0001995 organismal quality http://purl.obolibrary.org/obo/PATO_0001241 physical object quality A quality that inheres in an entire organism or part of an organism. http://purl.obolibrary.org/obo/OAE_0004372 ulcer http://purl.obolibrary.org/obo/OGMS_0000045 disorder A disorder material entity that forms an open sore on the skin or a mucous membrane, accompanied by the disintegration of tissue. http://purl.obolibrary.org/obo/UBERON_0000010 peripheral nervous system http://purl.obolibrary.org/obo/UBERON_0011216 organ system subdivision A major division of the nervous system that contains nerves which connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. http://purl.obolibrary.org/obo/UBERON_0000014 zone of skin http://purl.obolibrary.org/obo/UBERON_0034944 zone of organ Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis. http://purl.obolibrary.org/obo/UBERON_0000016 endocrine pancreas http://purl.obolibrary.org/obo/UBERON_0004119 endoderm-derived structure The part of the pancreas that is part of the endocrine system and is made up of islet cells, which produce insulin, glucagon and somatostatin. http://purl.obolibrary.org/obo/UBERON_0000020 sense organ http://purl.obolibrary.org/obo/UBERON_0000062 organ An organ that is capable of transducing sensory stimulus to the nervous system. http://purl.obolibrary.org/obo/UBERON_0000056 ureter http://purl.obolibrary.org/obo/UBERON_0015212 lateral structure Muscular duct that propels urine from the kidneys to the urinary bladder, or related organs. http://purl.obolibrary.org/obo/UBERON_0000059 large intestine http://purl.obolibrary.org/obo/UBERON_0013765 digestive system element A subdivision of the digestive tract that connects the small intestine to the cloaca or anus. Lacks or has few villi[Kardong]. http://purl.obolibrary.org/obo/UBERON_0000065 respiratory tract http://purl.obolibrary.org/obo/UBERON_0004119 endoderm-derived structure Anatomical structure that is part of the respiratory system. In mammals consists of upper and lower tracts http://purl.obolibrary.org/obo/UBERON_0000160 intestine http://purl.obolibrary.org/obo/UBERON_0004921 subdivision of digestive tract Segment of the alimentary canal extending from the stomach to the anus and, in humans and other mammals, consists of two segments, the small intestine and the large intestine. http://purl.obolibrary.org/obo/UBERON_0000165 mouth http://purl.obolibrary.org/obo/UBERON_0004921 subdivision of digestive tract The proximal portion of the digestive tract, containing the oral cavity and bounded by the oral opening. In vertebrates, this extends to the pharynx and includes gums, lips, tongue and parts of the palate. Typically also includes the teeth, except where these occur elsewhere (e.g. pharyngeal jaws) or protrude from the mouth (tusks). http://purl.obolibrary.org/obo/UBERON_0000178 blood http://purl.obolibrary.org/obo/UBERON_0000179 haemolymphatic fluid A fluid that is composed of blood plasma and erythrocytes. http://purl.obolibrary.org/obo/UBERON_0000467 anatomical system http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function. http://purl.obolibrary.org/obo/UBERON_0000945 stomach http://purl.obolibrary.org/obo/UBERON_0010039 food storage organ An expanded region of the vertebrate alimentary tract that serves as a food storage compartment and digestive organ. A stomach is lined, in whole or in part by a glandular epithelium. http://purl.obolibrary.org/obo/UBERON_0000948 heart http://purl.obolibrary.org/obo/UBERON_0010314 structure with developmental contribution from neural crest A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ. http://purl.obolibrary.org/obo/UBERON_0000949 endocrine system http://purl.obolibrary.org/obo/UBERON_0000467 anatomical system Anatomical system that consists of the glands and parts of glands that produce endocrine secretions and help to integrate and control bodily metabolic activity. http://purl.obolibrary.org/obo/UBERON_0000955 brain http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]. http://purl.obolibrary.org/obo/UBERON_0000964 cornea http://purl.obolibrary.org/obo/UBERON_0010313 neural crest-derived structure the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure http://purl.obolibrary.org/obo/UBERON_0000965 lens of camera-type eye http://purl.obolibrary.org/obo/UBERON_0005389 transparent eye structure Transparent part of camera-type eye that helps to refract light to be focused on the retina. http://purl.obolibrary.org/obo/UBERON_0000966 retina http://purl.obolibrary.org/obo/UBERON_0005388 photoreceptor array The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates. http://purl.obolibrary.org/obo/UBERON_0000970 eye http://purl.obolibrary.org/obo/UBERON_0000020 sense organ An organ that detects light. http://purl.obolibrary.org/obo/UBERON_0000990 reproductive system http://purl.obolibrary.org/obo/UBERON_0000467 anatomical system Anatomical system that has as its parts the organs concerned with reproduction. http://purl.obolibrary.org/obo/UBERON_0000992 female gonad http://purl.obolibrary.org/obo/UBERON_0003134 female reproductive organ the gonad of a female organism which contains germ cells http://purl.obolibrary.org/obo/UBERON_0000995 uterus http://purl.obolibrary.org/obo/UBERON_0013515 subdivision of oviduct the female muscular organ of gestation in which the developing embryo or fetus is nourished until birth http://purl.obolibrary.org/obo/UBERON_0000996 vagina http://purl.obolibrary.org/obo/UBERON_0013515 subdivision of oviduct A fibromuscular tubular tract leading from the uterus to the exterior of the body in female placental mammals and marsupials, or to the cloaca in female birds, monotremes, and some reptiles[WP]. http://purl.obolibrary.org/obo/UBERON_0001004 respiratory system http://purl.obolibrary.org/obo/UBERON_0000467 anatomical system Functional system which consists of structures involved in respiration. http://purl.obolibrary.org/obo/UBERON_0001016 nervous system http://purl.obolibrary.org/obo/UBERON_0000467 anatomical system The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior [CUMBO]. http://purl.obolibrary.org/obo/UBERON_0001017 central nervous system http://purl.obolibrary.org/obo/UBERON_0011216 organ system subdivision The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the neural tube derivatives: the brain and spinal cord. In invertebrates it includes central ganglia plus nerve cord. http://purl.obolibrary.org/obo/UBERON_0001032 sensory system http://purl.obolibrary.org/obo/UBERON_0000467 anatomical system Anatomical system that overlaps the nervous system and is responsible for receiving and processing sensory information. http://purl.obolibrary.org/obo/UBERON_0001043 esophagus http://purl.obolibrary.org/obo/UBERON_0013765 digestive system element Tube that connects the pharynx to the stomach. In mammals, the oesophagus connects the buccal cavity with the stomach. The stratified squamous non-keratinised epithelium lining the buccal cavity is continued through the pharynx down into the oesophagus. The lowest part of the oesophagus (ca. 2 cm) is lined with gastric mucosa and covered by peritoneum. The main body of the oesophagus is lined with small, simple mucous glands. Each gland opens into the lumen by a long duct which pierces the muscularis mucosae (Wilson and Washington, 1989). A sphincter is situated at the point where the oesophagus enters the stomach to prevent gastro-oesophageal reflux, i.e. to prevent acidic gastric contents from reaching stratified epithelia of the oesophagus, where they can cause inflammation and irritation (Wilson and Washington, 1989; Brown et al., 1993). http://purl.obolibrary.org/obo/UBERON_0001052 rectum http://purl.obolibrary.org/obo/UBERON_0004921 subdivision of digestive tract the terminal portion of the intestinal tube, terminating with the anus http://purl.obolibrary.org/obo/UBERON_0001134 skeletal muscle tissue http://purl.obolibrary.org/obo/UBERON_0002036 striated muscle tissue Muscle tissue that consists primarily of skeletal muscle fibers. http://purl.obolibrary.org/obo/UBERON_0001153 caecum http://purl.obolibrary.org/obo/UBERON_0009854 digestive tract diverticulum A pouch in the digestive tract that connects the ileum with the ascending colon of the large intestine. It is separated from the ileum by the ileocecal valve, and is the beginning of the large intestine. It is also separated from the colon by the cecocolic junction. http://purl.obolibrary.org/obo/UBERON_0001154 vermiform appendix http://purl.obolibrary.org/obo/UBERON_0013765 digestive system element A blind-ended tube connected to the cecum, from which it develops embryologically[WP]. http://purl.obolibrary.org/obo/UBERON_0001155 colon http://purl.obolibrary.org/obo/UBERON_0004921 subdivision of digestive tract Last portion of the large intestine before it becomes the rectum. http://purl.obolibrary.org/obo/UBERON_0001158 descending colon http://purl.obolibrary.org/obo/UBERON_0000168 proximal-distal subdivision of colon The portion of the colon between the left colic flexure and the sigmoid colon at the pelvic brim; the portion of the descending colon lying in the left iliac fossa is sometimes called the iliac colon. http://purl.obolibrary.org/obo/UBERON_0001159 sigmoid colon http://purl.obolibrary.org/obo/UBERON_0000168 proximal-distal subdivision of colon The part of the large intestine that is closest to the rectum and anus. It forms a loop that averages about 40 cm. in length, and normally lies within the pelvis, but on account of its freedom of movement it is liable to be displaced into the abdominal cavity. http://purl.obolibrary.org/obo/UBERON_0001165 pyloric antrum http://purl.obolibrary.org/obo/UBERON_0009870 zone of stomach the area at the bottom of the stomach on the caudal side of the pyloric canal that contains gastrin-producing G cells, which stimulate acid production, and the luminal pH-sensitive population of somatostatin-producing D cells http://purl.obolibrary.org/obo/UBERON_0001166 pylorus http://purl.obolibrary.org/obo/UBERON_0009870 zone of stomach the stomach tissue region surrounding and controlling the distal outlet of the stomach, which opens into the duodenum http://purl.obolibrary.org/obo/UBERON_0001245 anus http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure Orifice at the opposite end of an animal's digestive tract from the mouth. Its function is to expel feces, unwanted semi-solid matter produced during digestion, which, depending on the type of animal, may be one or more of: matter which the animal cannot digest, such as bones; food material after all the nutrients have been extracted, for example cellulose or lignin; ingested matter which would be toxic if it remained in the digestive tract; and dead or excess gut bacteria and other endosymbionts. http://purl.obolibrary.org/obo/UBERON_0001255 urinary bladder http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure distensible musculomembranous organ situated in the anterior part of the pelvic cavity in which urine collects before excretion[MP]. http://purl.obolibrary.org/obo/UBERON_0001558 lower respiratory tract http://purl.obolibrary.org/obo/UBERON_0000072 proximo-distal subdivision of respiratory tract The segment of the respiratory tract that starts proximally with the trachea and includes all distal structures including the lungs[WP,modified] http://purl.obolibrary.org/obo/UBERON_0001637 artery http://purl.obolibrary.org/obo/UBERON_0003509 arterial blood vessel An epithelial tube or tree of tibes that transports blood away from the heart[modified from AEO definition]. http://purl.obolibrary.org/obo/UBERON_0001705 nail http://purl.obolibrary.org/obo/UBERON_0009564 distal limb integumentary appendage A horn-like keratin structure covering the dorsal aspect of the terminal phalanges of fingers and toes[WP]. http://purl.obolibrary.org/obo/UBERON_0001711 eyelid http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure A fold of skin that covers and protects part of the eyeball. Examples: upper eyelid, lower eyelid, nictitating membrane http://purl.obolibrary.org/obo/UBERON_0001737 larynx http://purl.obolibrary.org/obo/UBERON_0000072 proximo-distal subdivision of respiratory tract A continuation of the pharynx that is involved in breathing, sound production, and protecting the trachea against food aspiration. http://purl.obolibrary.org/obo/UBERON_0001759 vagus nerve http://purl.obolibrary.org/obo/UBERON_0001785 cranial nerve Cranial nerve that branches into the lateral (to body sense organs) and the intestino-accessorial (to the skin, muscles of shoulder, hyoid, larynx, gut, lungs, and heart). http://purl.obolibrary.org/obo/UBERON_0001776 optic choroid http://purl.obolibrary.org/obo/UBERON_0002203 vasculature of eye vascular layer containing connective tissue, of the eye lying between the retina and the sclera. The choroid provides oxygen and nourishment to the outer layers of the retina. Along with the ciliary body and iris, the choroid forms the uveal tract[WP]. http://purl.obolibrary.org/obo/UBERON_0001833 lip http://purl.obolibrary.org/obo/UBERON_0003102 surface structure One of the two fleshy folds which surround the opening of the mouth. http://purl.obolibrary.org/obo/UBERON_0001982 capillary http://purl.obolibrary.org/obo/UBERON_0010523 microcirculatory vessel Any of the smallest blood vessels connecting arterioles with venules. http://purl.obolibrary.org/obo/UBERON_0002046 thyroid gland http://purl.obolibrary.org/obo/UBERON_0010314 structure with developmental contribution from neural crest A two-lobed endocrine gland found in all vertebrates, located in front of and on either side of the trachea in humans, and producing various hormones, such as triiodothyronine and calcitonin[BTO]. http://purl.obolibrary.org/obo/UBERON_0002048 lung http://purl.obolibrary.org/obo/UBERON_0015212 lateral structure Respiration organ that develops as an oupocketing of the esophagus. http://purl.obolibrary.org/obo/UBERON_0002101 limb http://purl.obolibrary.org/obo/UBERON_0004708 paired limb/fin A paired appendage that is evolved from a paired fin. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the girdle and its parts. http://purl.obolibrary.org/obo/UBERON_0002107 liver http://purl.obolibrary.org/obo/UBERON_0006925 digestive gland An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]. http://purl.obolibrary.org/obo/UBERON_0002108 small intestine http://purl.obolibrary.org/obo/UBERON_0013765 digestive system element Subdivision of digestive tract that connects the stomach to the large intestine and is where much of the digestion and absorption of food takes place (with the exception of ruminants). The mammalian small intestine is long and coiled and can be differentiated histologically into: duodenum, jejunem, ileum[WP,cjm,Kardong]. http://purl.obolibrary.org/obo/UBERON_0002110 gall bladder http://purl.obolibrary.org/obo/UBERON_0017672 abdominal viscera An organ that aids digestion and stores bile produced by the liver[WP]. http://purl.obolibrary.org/obo/UBERON_0002113 kidney http://purl.obolibrary.org/obo/UBERON_0015212 lateral structure A paired organ of the urinary tract which has the production of urine as its primary function. http://purl.obolibrary.org/obo/UBERON_0002114 duodenum http://purl.obolibrary.org/obo/UBERON_0004921 subdivision of digestive tract The first part of the small intestine. At the junction of the stomach and the duodenum the alimentary canal is inflected. The duodenum first goes anteriorly for a short distance, turns dorsally, and eventually caudally, thus it is a U-shaped structure with two horizontal sections (a ventral and a dorsal one). http://purl.obolibrary.org/obo/UBERON_0002185 bronchus http://purl.obolibrary.org/obo/UBERON_0000117 respiratory tube the upper conducting airways of the lung; these airways arise from the terminus of the trachea http://purl.obolibrary.org/obo/UBERON_0002204 musculoskeletal system http://purl.obolibrary.org/obo/UBERON_0000467 anatomical system Anatomical system that consists of the muscular and skeletal systems. http://purl.obolibrary.org/obo/UBERON_0002240 spinal cord http://purl.obolibrary.org/obo/UBERON_0010314 structure with developmental contribution from neural crest Part of the central nervous system located in the vertebral canal continuous with and caudal to the brain; demarcated from brain by plane of foramen magnum. It is composed of an inner core of gray matter in which nerve cells predominate, and an outer layer of white matter in which myelinated nerve fibers predominate, and surrounds the central canal. (CUMBO) http://purl.obolibrary.org/obo/UBERON_0002298 brainstem http://purl.obolibrary.org/obo/UBERON_0010314 structure with developmental contribution from neural crest Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized]. http://purl.obolibrary.org/obo/UBERON_0002330 exocrine system http://purl.obolibrary.org/obo/UBERON_0000467 anatomical system Anatomical system that consists of the glands and parts of glands that produce exocrine secretions and help to integrate and control bodily metabolic activity. Exocrine glands are glands that secrete their products (hormones) into ducts (duct glands). They are the counterparts to endocrine glands, which secrete their products (hormones) directly into the bloodstream (ductless glands) or release hormones (paracrines) that affect only target cells nearby the release site. [Wikipedia]. http://purl.obolibrary.org/obo/UBERON_0002351 sinoatrial node http://purl.obolibrary.org/obo/UBERON_0010131 conducting tissue of heart The part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node[GO]. Subdivision of conducting system of heart at the junction of the right atrium and the superior vena cava, around the sinoatrial nodal branch of right coronary artery and is continuous with the internodal tract[FMA]. http://purl.obolibrary.org/obo/UBERON_0002367 prostate gland http://purl.obolibrary.org/obo/UBERON_0010147 male accessory sex gland The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid. http://purl.obolibrary.org/obo/UBERON_0002368 endocrine gland http://purl.obolibrary.org/obo/UBERON_0002530 gland Endocrine glands are glands of the endocrine system that secrete their products directly into the circulatory system rather than through a duct.[WP, modified]. http://purl.obolibrary.org/obo/UBERON_0002384 connective tissue http://purl.obolibrary.org/obo/UBERON_0000479 tissue Tissue with cells that deposit non-polarized extracellular matrix including connective tissue fibers and ground substance. http://purl.obolibrary.org/obo/UBERON_0002387 pes http://purl.obolibrary.org/obo/UBERON_0008784 lower limb segment distal portion of the hind limb, including tarsal region, metatarsal region and digits. http://purl.obolibrary.org/obo/UBERON_0002394 bile duct http://purl.obolibrary.org/obo/UBERON_0004119 endoderm-derived structure Any of the ducts that form the biliary tree, carrying bile from the liver to the small intestine. http://purl.obolibrary.org/obo/UBERON_0002405 immune system http://purl.obolibrary.org/obo/UBERON_0000467 anatomical system Anatomical system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies. http://purl.obolibrary.org/obo/UBERON_0002416 integumental system http://purl.obolibrary.org/obo/UBERON_0000467 anatomical system Connected anatomical system that forms a barrier between an animal and its environment. In vertebrates, the integumental system consists of the epidermis, dermis plus associated glands and adnexa such as hair and scales. In invertebrates, the integumental system may include cuticle. http://purl.obolibrary.org/obo/UBERON_0003126 trachea http://purl.obolibrary.org/obo/UBERON_0000117 respiratory tube The trachea is the portion of the airway that attaches to the bronchi as it branches [GO:dph]. http://purl.obolibrary.org/obo/UBERON_0003133 reproductive organ http://purl.obolibrary.org/obo/UBERON_0005156 reproductive structure An organ involved in reproduction http://purl.obolibrary.org/obo/UBERON_0003134 female reproductive organ http://purl.obolibrary.org/obo/UBERON_0003133 reproductive organ A female organ involved in reproduction http://purl.obolibrary.org/obo/UBERON_0003221 phalanx http://purl.obolibrary.org/obo/UBERON_0015023 phalanx endochondral element Endochondral bones that are often elongate and arranged in rows of articulating elements, and form the visible part of the digits. http://purl.obolibrary.org/obo/UBERON_0003703 extrahepatic bile duct http://purl.obolibrary.org/obo/UBERON_0002394 bile duct Passages external to the liver for the conveyance of bile. These include the common bile duct and the common hepatic duct. http://purl.obolibrary.org/obo/UBERON_0004117 pharyngeal pouch http://purl.obolibrary.org/obo/UBERON_0005291 embryonic tissue An internal pocketing of pharyngeal endoderm that contacts a region of ectoderm (a pharyngeal cleft) and interdigitates in the anterior and posterior directions with the pharyngeal arches. http://purl.obolibrary.org/obo/UBERON_0004535 cardiovascular system http://purl.obolibrary.org/obo/UBERON_0000467 anatomical system Anatomical system that has as its parts the heart and blood vessels. http://purl.obolibrary.org/obo/UBERON_0004913 hepatopancreatic ampulla http://purl.obolibrary.org/obo/UBERON_0002394 bile duct A dilation of the duodenal papilla that is the opening of the juncture of the common bile duct and the main pancreatic duct. http://purl.obolibrary.org/obo/UBERON_0005409 alimentary part of gastrointestinal system http://purl.obolibrary.org/obo/UBERON_0000467 anatomical system The part of the digestive system that excludes the hepatobiliary system. http://purl.obolibrary.org/obo/UBERON_0006562 pharynx http://purl.obolibrary.org/obo/UBERON_0004921 subdivision of digestive tract The pharynx is the part of the digestive system immediately posterior to the mouth[GO]. http://purl.obolibrary.org/obo/UBERON_0035642 laryngeal nerve http://purl.obolibrary.org/obo/UBERON_0001021 nerve Any nerve that innervates the larynx. http://purl.obolibrary.org/obo/UBERON_0000006 islet of Langerhans http://purl.obolibrary.org/obo/UBERON_0034922 cell cluster the clusters of hormone-producing cells that are scattered throughout the pancreas http://purl.obolibrary.org/obo/UBERON_0000015 anatomical boundary http://purl.obolibrary.org/obo/UBERON_0000466 immaterial anatomical entity A non-material anatomical entity of two dimensions. Anatomical boundaries are contiguous structures. http://purl.obolibrary.org/obo/UBERON_0000019 camera-type eye http://purl.obolibrary.org/obo/UBERON_0015212 lateral structure An organ of sight that includes the camera-type eyeball and supporting structures such as the lacrimal apparatus, the conjunctiva, the eyelid. http://purl.obolibrary.org/obo/UBERON_0000025 tube http://purl.obolibrary.org/obo/UBERON_0004111 anatomical conduit Any hollow cylindrical anatomical structure containing a lumen through which substances are transported. http://purl.obolibrary.org/obo/UBERON_0000026 appendage http://purl.obolibrary.org/obo/UBERON_0000475 organism subdivision Major subdivision of an organism that protrudes from the body[DOS, CARO]. http://purl.obolibrary.org/obo/UBERON_0000042 serous membrane http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure multi-tissue structure that is comprised of a secretory epithelial layer (mesothelium) and a connective tissue layer. http://purl.obolibrary.org/obo/UBERON_0000043 tendon http://purl.obolibrary.org/obo/UBERON_0007846 dense regular connective tissue Dense regular connective tissue that connects muscle to bone[VSAO]. http://purl.obolibrary.org/obo/UBERON_0000045 ganglion http://purl.obolibrary.org/obo/UBERON_0010001 cell cluster organ A biological tissue mass, most commonly a mass of nerve cell bodies. http://purl.obolibrary.org/obo/UBERON_0000047 simple eye http://purl.obolibrary.org/obo/UBERON_0000970 eye An eye with one concave chamber. Note that 'simple' does not imply a reduced level of complexity or acuity. http://purl.obolibrary.org/obo/UBERON_0000055 vessel http://purl.obolibrary.org/obo/UBERON_0004111 anatomical conduit A tubular structure that contains, conveys body fluid, such as blood or lymph. http://purl.obolibrary.org/obo/UBERON_0000058 duct http://purl.obolibrary.org/obo/UBERON_0000063 organ subunit A tubular structure that transports secreted or excreted substances. http://purl.obolibrary.org/obo/UBERON_0000060 anatomical wall http://purl.obolibrary.org/obo/UBERON_0000064 organ part Organ component adjacent to an organ cavity and which consists of a maximal aggregate of organ component layers. http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure http://purl.obolibrary.org/obo/UBERON_0000465 material anatomical entity Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome. http://purl.obolibrary.org/obo/UBERON_0000062 organ http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure Anatomical structure that performs a specific function or group of functions [WP]. http://purl.obolibrary.org/obo/UBERON_0000063 organ subunit http://purl.obolibrary.org/obo/UBERON_0000064 organ part A part of an organ that constitutes a distinct modular sub-unit. In some cases, the organ may also contain other sub-units of identical or similar types, in other cases this may be a distinct entity. http://purl.obolibrary.org/obo/UBERON_0000064 organ part http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure A multicellular structure that is a part of an organ. http://purl.obolibrary.org/obo/UBERON_0000066 fully formed stage http://purl.obolibrary.org/obo/UBERON_0000105 life cycle stage The stage of development at which the animal is fully formed, including immaturity and maturity. Includes both sexually immature stage, and adult stage. http://purl.obolibrary.org/obo/UBERON_0000067 embryo stage part http://purl.obolibrary.org/obo/UBERON_0000105 life cycle stage A stage that is part of the embryo stage. http://purl.obolibrary.org/obo/UBERON_0000068 embryo stage http://purl.obolibrary.org/obo/UBERON_0000105 life cycle stage A life cycle stage that starts with fertilization and ends with the fully formed embryo. http://purl.obolibrary.org/obo/UBERON_0000071 death stage http://purl.obolibrary.org/obo/UBERON_0000105 life cycle stage End of the life of an organism. http://purl.obolibrary.org/obo/UBERON_0000072 proximo-distal subdivision of respiratory tract http://purl.obolibrary.org/obo/UBERON_0013522 subdivision of tube An section of a respiratory tract. http://purl.obolibrary.org/obo/UBERON_0000073 regional part of nervous system http://purl.obolibrary.org/obo/UBERON_0000481 multi-tissue structure Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS. http://purl.obolibrary.org/obo/UBERON_0000075 subdivision of skeletal system http://purl.obolibrary.org/obo/UBERON_0011216 organ system subdivision Anatomical cluster consisting of the skeletal elements and articular elements that are part of an individual subdivision of the organism. http://purl.obolibrary.org/obo/UBERON_0000076 external ectoderm http://purl.obolibrary.org/obo/UBERON_0005291 embryonic tissue The surface (external) layer of ectoderm which begins to proliferate shortly after separation from the neuroectoderm. http://purl.obolibrary.org/obo/UBERON_0000077 mixed endoderm/mesoderm-derived structure http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure An anatomical structure that develops from the endoderm and the mesoderm. http://purl.obolibrary.org/obo/UBERON_0000080 mesonephros http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure The second stage of the kidney. It serves as the main excretory organ of aquatic vertebrates and as a temporary embryonic kidney in higher vertebrates. It is composed of the mesonephric duct (also called the Wolffian duct), mesonephric tubules, and associated capillary tufts. A single tubule and its associated capillary tuft is called a mesonephric excretory unit; these units are similar in structure and function to nephrons of the adult kidney. The mesonephros is derived from intermediate mesoderm in the vertebrate embryo. http://purl.obolibrary.org/obo/UBERON_0000081 metanephros http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine[GO] http://purl.obolibrary.org/obo/UBERON_0000083 mesonephric tubule http://purl.obolibrary.org/obo/UBERON_0006555 excretory tube A mesonephric tubule is an epithelial tube that is part of the mesonephros[GO]. Genital ridge that is next to the mesonephros[WP]. http://purl.obolibrary.org/obo/UBERON_0000084 ureteric bud http://purl.obolibrary.org/obo/UBERON_0034969 epithelial layer of duct An epithelial swelling on the Wolffian duct that elongates to invade the adjacent metanephric mesenchyme[MP] http://purl.obolibrary.org/obo/UBERON_0000092 post-embryonic stage http://purl.obolibrary.org/obo/UBERON_0000105 life cycle stage stage succeeding embryo, including mature structure http://purl.obolibrary.org/obo/UBERON_0000094 membrane organ http://purl.obolibrary.org/obo/UBERON_0000062 organ Nonparenchymatous organ that primarily consists of dense connective tissue organized into a sheet which interconnects two or more organs, separates two or more body spaces from one another, or surrounds an organ or body part. Examples: interosseous membrane of forearm, obturator membrane, tympanic membrane, fibrous pericardium, fascia lata, dura mater. [FMA] http://purl.obolibrary.org/obo/UBERON_0000104 life cycle http://purl.obolibrary.org/obo/BFO_0000015 process An entire span of an organism's life, commencing with the zygote stage and ending in the death of the organism. http://purl.obolibrary.org/obo/UBERON_0000105 life cycle stage http://purl.obolibrary.org/obo/BFO_0000015 process A spatiotemporal region encompassing some part of the life cycle of an organism. http://purl.obolibrary.org/obo/UBERON_0000106 zygote stage http://purl.obolibrary.org/obo/UBERON_0000067 embryo stage part A stage at which the organism is a single cell produced by means of sexual reproduction. http://purl.obolibrary.org/obo/UBERON_0000107 cleavage stage http://purl.obolibrary.org/obo/UBERON_0000067 embryo stage part The first few specialized divisions of an activated animal egg; Stage consisting of division of cells in the early embryo. The zygotes of many species undergo rapid cell cycles with no significant growth, producing a cluster of cells the same size as the original zygote. The different cells derived from cleavage are called blastomeres and form a compact mass called the morula. Cleavage ends with the formation of the blastula. http://purl.obolibrary.org/obo/UBERON_0000108 blastula stage http://purl.obolibrary.org/obo/UBERON_0000067 embryo stage part An early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. http://purl.obolibrary.org/obo/UBERON_0000109 gastrula stage http://purl.obolibrary.org/obo/UBERON_0000067 embryo stage part A stage defined by complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm. http://purl.obolibrary.org/obo/UBERON_0000110 neurula stage http://purl.obolibrary.org/obo/UBERON_0000067 embryo stage part Staged defined by the formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system. http://purl.obolibrary.org/obo/UBERON_0000111 organogenesis stage http://purl.obolibrary.org/obo/UBERON_0000067 embryo stage part A stage at which the ectoderm, endoderm, and mesoderm develop into the internal organs of the organism. http://purl.obolibrary.org/obo/UBERON_0000117 respiratory tube http://purl.obolibrary.org/obo/UBERON_0004119 endoderm-derived structure A tube in the respiratory system. Examples: bronchus, bronchiole, trachea. http://purl.obolibrary.org/obo/UBERON_0000118 lung bud http://purl.obolibrary.org/obo/UBERON_0005911 endo-epithelium Structure derived from foregut that becomes a lung[GO]. http://purl.obolibrary.org/obo/UBERON_0000122 neuron projection bundle http://purl.obolibrary.org/obo/UBERON_0005162 multi cell part structure A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses. http://purl.obolibrary.org/obo/UBERON_0000125 neural nucleus http://purl.obolibrary.org/obo/UBERON_0011215 central nervous system cell part cluster A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO) http://purl.obolibrary.org/obo/UBERON_0000126 cranial nerve nucleus http://purl.obolibrary.org/obo/UBERON_0002308 nucleus of brain Nucleus that receives projections from or contains neurons that send projections through one of the cranial nerves http://purl.obolibrary.org/obo/UBERON_0000161 orifice http://purl.obolibrary.org/obo/UBERON_0004111 anatomical conduit Anatomical conduit that connects two adjacent body spaces (or a body space with the space surrounding the organism)[FMA,modified]. http://purl.obolibrary.org/obo/UBERON_0000162 cloaca http://purl.obolibrary.org/obo/UBERON_0013522 subdivision of tube Common chamber into which the intestines and excretory system opens. Arises during development in all vertebrates, but in many it becomes subdivided, lost or incorporated into other structures http://purl.obolibrary.org/obo/UBERON_0000163 embryonic cloaca http://purl.obolibrary.org/obo/UBERON_0002050 embryonic structure endoderm-lined chamber that develops as pouch-like dilation of the caudal end of the hindgut and receives the allantois ventrally and two mesonephric ducts laterally; caudally it ends blindly at the cloacal membrane formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm[MP]. http://purl.obolibrary.org/obo/UBERON_0000164 primitive urogenital sinus http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure the ventral part of the cloaca remaining after septation of the rectum, which further develops into part of the bladder, part of the prostatic part of the male urethra and the urethra and vestibule in females http://purl.obolibrary.org/obo/UBERON_0000166 oral opening http://purl.obolibrary.org/obo/UBERON_0000161 orifice The orifice that connects the mouth to the exterior of the body. http://purl.obolibrary.org/obo/UBERON_0000168 proximal-distal subdivision of colon http://purl.obolibrary.org/obo/UBERON_0004921 subdivision of digestive tract A section dividing a colon along a proximal-distal axis. http://purl.obolibrary.org/obo/UBERON_0000170 pair of lungs http://purl.obolibrary.org/obo/UBERON_0034925 anatomical collection The pair of anatomical structures comprised of a left lung and right lung. http://purl.obolibrary.org/obo/UBERON_0000171 respiration organ http://purl.obolibrary.org/obo/UBERON_0000062 organ Organ that functions in gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. http://purl.obolibrary.org/obo/UBERON_0000174 excreta http://purl.obolibrary.org/obo/UBERON_0000463 organism substance A portion of organism substance that is the product of an excretion process that will be eliminated from the body. An excretion process is elimination by an organism of the waste products that arise as a result of metabolic activity http://purl.obolibrary.org/obo/UBERON_0000179 haemolymphatic fluid http://purl.obolibrary.org/obo/UBERON_0006314 bodily fluid Circulating fluid that is part of the hemolymphoid system. Blood, lymph, interstitial fluid or its analogs. http://purl.obolibrary.org/obo/UBERON_0000307 blastula http://purl.obolibrary.org/obo/UBERON_0000922 embryo Organism at the blastula stage - an early stage of embryonic development in animals. It is produced by cleavage of a fertilized ovum and consists of a spherical layer of around 128 cells surrounding a central fluid-filled cavity called the blastocoel. The blastula follows the morula and precedes the gastrula in the developmental sequence. http://purl.obolibrary.org/obo/UBERON_0000320 duodenal mucosa http://purl.obolibrary.org/obo/UBERON_0001204 mucosa of small intestine A mucosa that is part of a duodenum [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0000325 gastric gland http://purl.obolibrary.org/obo/UBERON_0003294 gland of foregut The branched tubular glands found in the mucosa of the fundus and body of the stomach which contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin. http://purl.obolibrary.org/obo/UBERON_0000328 gut wall http://purl.obolibrary.org/obo/UBERON_0000060 anatomical wall The wall of the digestive tract. This encompasses all parts of the digestive tract with the exception of the lumen (cavity). http://purl.obolibrary.org/obo/UBERON_0000341 throat http://purl.obolibrary.org/obo/UBERON_0034929 external soft tissue zone In anatomy, the throat is the anterior part of the neck, in front of the vertebral column. It consists of the pharynx and larynx. An important feature of the throat is the epiglottis, a flap which separates the esophagus from the trachea and prevents inhalation of food or drink. The throat contains various blood vessels, various pharyngeal muscles, the trachea (windpipe) and the esophagus. The hyoid bone and the clavicle are the only bones located in the throat of mammals. It is sometimes considered a synonym for fauces. [WP,unvetted]. http://purl.obolibrary.org/obo/UBERON_0000344 mucosa http://purl.obolibrary.org/obo/UBERON_0004923 organ component layer A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP] http://purl.obolibrary.org/obo/UBERON_0000353 parenchyma http://purl.obolibrary.org/obo/UBERON_0000064 organ part functional part of an organ in the body. This is in contrast to the stroma, which refers to the structural tissue of organs, being exactly, connective tissues. http://purl.obolibrary.org/obo/UBERON_0000383 musculature of body http://purl.obolibrary.org/obo/UBERON_0011216 organ system subdivision The subdivision of the musculoskeletal system that consists of all the muscles of the body[VSAO, modified]. http://purl.obolibrary.org/obo/UBERON_0000409 serous gland http://purl.obolibrary.org/obo/UBERON_0002365 exocrine gland A gland in which the principal secretory cells are serous secreting cells. http://purl.obolibrary.org/obo/UBERON_0000414 mucous gland http://purl.obolibrary.org/obo/UBERON_0002365 exocrine gland A gland in which the principal secretory cells are mucus secreting cells. http://purl.obolibrary.org/obo/UBERON_0000456 bodily secretion http://purl.obolibrary.org/obo/UBERON_0000463 organism substance A portion of organism substance that is produced by exocrine glands. http://purl.obolibrary.org/obo/UBERON_0000463 organism substance http://purl.obolibrary.org/obo/UBERON_0000465 material anatomical entity Material anatomical entity in a gaseous, liquid, semisolid or solid state; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures as they pass through the body. http://purl.obolibrary.org/obo/UBERON_0000464 anatomical space http://purl.obolibrary.org/obo/UBERON_0000466 immaterial anatomical entity Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures. http://purl.obolibrary.org/obo/UBERON_0000465 material anatomical entity http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity Anatomical entity that has mass. http://purl.obolibrary.org/obo/UBERON_0000466 immaterial anatomical entity http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity Anatomical entity that has no mass. http://purl.obolibrary.org/obo/UBERON_0000468 multicellular organism http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure Anatomical structure that is an individual member of a species and consists of more than one cell. http://purl.obolibrary.org/obo/UBERON_0000471 compound organ component http://purl.obolibrary.org/obo/UBERON_0000481 multi-tissue structure Multi-tissue structure that is part of a compound organ. http://purl.obolibrary.org/obo/UBERON_0000475 organism subdivision http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure Anatomical structure which is a subdivision of a whole organism, consisting of components of multiple anatomical systems, largely surrounded by a contiguous region of integument. http://purl.obolibrary.org/obo/UBERON_0000476 acellular anatomical structure http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure Anatomical structure that consists of cell parts and cell substances and together does not constitute a cell or a tissue. http://purl.obolibrary.org/obo/UBERON_0000477 anatomical cluster http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity Anatomical group that has its parts adjacent to one another. http://purl.obolibrary.org/obo/UBERON_0000479 tissue http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation. http://purl.obolibrary.org/obo/UBERON_0000481 multi-tissue structure http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types. http://purl.obolibrary.org/obo/UBERON_0000483 epithelium http://purl.obolibrary.org/obo/UBERON_0000479 tissue Portion of tissue, that consists of one or more layers of epithelial cells connected to each other by cell junctions and which is underlain by a basal lamina. Examples: simple squamous epithelium, glandular cuboidal epithelium, transitional epithelium, myoepithelium[CARO]. http://purl.obolibrary.org/obo/UBERON_0000485 simple columnar epithelium http://purl.obolibrary.org/obo/UBERON_0012274 columnar epithelium Unilaminar epithelium, which consists of a single layer of columnar cells. Examples: ciliated columnar epithelium, gastric epithelium, microvillus columnar epithelium.[FMA] http://purl.obolibrary.org/obo/UBERON_0000486 multilaminar epithelium http://purl.obolibrary.org/obo/UBERON_0000483 epithelium Epithelium which consists of more than one layer of epithelial cells that may or may not be in contact with a basement membrane. Examples: keratinized stratified squamous epithelium, ciliated stratified columnar epithelium.[FMA] http://purl.obolibrary.org/obo/UBERON_0000487 simple squamous epithelium http://purl.obolibrary.org/obo/UBERON_0006914 squamous epithelium Unilaminar epithelium which consists of a single layer of squamous cells. Examples: pulmonary alveolar epithelium, endothelium.[FMA] http://purl.obolibrary.org/obo/UBERON_0000489 cavitated compound organ http://purl.obolibrary.org/obo/UBERON_0003103 compound organ Compound organ that contains one or more macroscopic anatomical spaces. http://purl.obolibrary.org/obo/UBERON_0000490 unilaminar epithelium http://purl.obolibrary.org/obo/UBERON_0000483 epithelium Epithelium which consists of a single layer of epithelial cells. Examples: endothelium, mesothelium, glandular squamous epithelium.[FMA] http://purl.obolibrary.org/obo/UBERON_0000912 mucus http://purl.obolibrary.org/obo/UBERON_0006314 bodily fluid Mucus is a bodily fluid consisting of a slippery secretion of the lining of the mucous membranes in the body. It is a viscous colloid containing antiseptic enzymes (such as lysozyme) and immunoglobulins. Mucus is produced by goblet cells in the mucous membranes that cover the surfaces of the membranes. It is made up of mucins and inorganic salts suspended in water. http://purl.obolibrary.org/obo/UBERON_0000916 abdomen http://purl.obolibrary.org/obo/UBERON_0009569 subdivision of trunk The subdivision of the vertebrate body between the thorax and pelvis. The ventral part of the abdomen contains the abdominal cavity and visceral organs. The dorsal part includes the abdominal section of the vertebral column. http://purl.obolibrary.org/obo/UBERON_0000922 embryo http://purl.obolibrary.org/obo/UBERON_0000468 multicellular organism Anatomical entity that comprises the organism in the early stages of growth and differentiation that are characterized by cleavage, the laying down of fundamental tissues, and the formation of primitive organs and organ systems. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant. http://purl.obolibrary.org/obo/UBERON_0000923 germ layer http://purl.obolibrary.org/obo/UBERON_0010316 germ layer / neural crest A layer of cells produced during the process of gastrulation during the early development of the animal embryo, which is distinct from other such layers of cells, as an early step of cell differentiation. The three types of germ layers are the endoderm, ectoderm, and mesoderm. http://purl.obolibrary.org/obo/UBERON_0000924 ectoderm http://purl.obolibrary.org/obo/UBERON_0000923 germ layer Primary germ layer that is the outer of the embryo's three germ layers and gives rise to epidermis and neural tissue. http://purl.obolibrary.org/obo/UBERON_0000925 endoderm http://purl.obolibrary.org/obo/UBERON_0000923 germ layer Primary germ layer that lies remote from the surface of the embryo and gives rise to internal tissues such as gut. http://purl.obolibrary.org/obo/UBERON_0000926 mesoderm http://purl.obolibrary.org/obo/UBERON_0000923 germ layer The middle germ layer of the embryo, between the endoderm and ectoderm. http://purl.obolibrary.org/obo/UBERON_0000930 stomodeum http://purl.obolibrary.org/obo/UBERON_0013522 subdivision of tube Anterior part of the embryonic digestive tract that develops into a mouth. The stomodeum includes as parts an invagination of the ectoderm and the stomodeal cavity. http://purl.obolibrary.org/obo/UBERON_0000931 proctodeum http://purl.obolibrary.org/obo/UBERON_0016566 pit Inward fold on the surface of the embryonic ectoderm that develops into an ectodermal terminal part of the digestive tract. http://purl.obolibrary.org/obo/UBERON_0000978 leg http://purl.obolibrary.org/obo/UBERON_0008784 lower limb segment The portion of the hindlimb that contains both the stylopod and zeugopod. http://purl.obolibrary.org/obo/UBERON_0000982 skeletal joint http://purl.obolibrary.org/obo/UBERON_0004905 articulation Anatomical cluster that consists of two or more adjacent skeletal structures, which may be interconnected by various types of tissue[VSAO]. http://purl.obolibrary.org/obo/UBERON_0000993 oviduct http://purl.obolibrary.org/obo/UBERON_0005156 reproductive structure A tube or collection of tubes in an animal from the ovaries to the outside of the body. http://purl.obolibrary.org/obo/UBERON_0001005 respiratory airway http://purl.obolibrary.org/obo/UBERON_0003103 compound organ An airway through which respiratory air passes in organisms. http://purl.obolibrary.org/obo/UBERON_0001009 circulatory system http://purl.obolibrary.org/obo/UBERON_0000467 anatomical system organ system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells, etc. to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis[WP]. http://purl.obolibrary.org/obo/UBERON_0001013 adipose tissue http://purl.obolibrary.org/obo/UBERON_0011822 dense irregular connective tissue Portion of connective tissue composed of adipocytes enmeshed in areolar tissue http://purl.obolibrary.org/obo/UBERON_0001015 musculature http://purl.obolibrary.org/obo/UBERON_0011216 organ system subdivision A subdivision of the muscular system corresponding to a subdisivision of an organism. http://purl.obolibrary.org/obo/UBERON_0001021 nerve http://purl.obolibrary.org/obo/UBERON_0000122 neuron projection bundle An enclosed, cable-like bundle of axons in the peripheral nervous system originating in a nerve root in the central nervous system (or a condensed nervous structure) connecting with peripheral structures. http://purl.obolibrary.org/obo/UBERON_0001033 gustatory system http://purl.obolibrary.org/obo/UBERON_0000467 anatomical system The sensory system for the sense of taste. http://purl.obolibrary.org/obo/UBERON_0001041 foregut http://purl.obolibrary.org/obo/UBERON_0004921 subdivision of digestive tract Anterior subdivision of a digestive tract. http://purl.obolibrary.org/obo/UBERON_0001042 chordate pharynx http://purl.obolibrary.org/obo/UBERON_0004185 endodermal part of digestive tract A portion of the respiratory and digestive tracts; its distal limit is the superior part of the esophagus and it connects the nasal and oral cavities with the esophagus and larynx; it contains the valleculae and the pyriform recesses; its upper limits are the nasal cavity and cranial base.[FEED]. http://purl.obolibrary.org/obo/UBERON_0001045 midgut http://purl.obolibrary.org/obo/UBERON_0004921 subdivision of digestive tract Middle subdivision of a digestive tract[CJM]. In vertebrates: The middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine[GO]. http://purl.obolibrary.org/obo/UBERON_0001046 hindgut http://purl.obolibrary.org/obo/UBERON_0004921 subdivision of digestive tract The caudalmost subdivision of a digestive tract. http://purl.obolibrary.org/obo/UBERON_0001048 primordium http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure Primordia are populations of contiguous cells that are morphologically distinct and already correspond in extent to a later organ/tissue[FBbt, Hartenstein, V. (2004)]. http://purl.obolibrary.org/obo/UBERON_0001049 neural tube http://purl.obolibrary.org/obo/UBERON_0016879 future central nervous system In the developing vertebrate, the neural tube is the embryo's precursor to the central nervous system, which comprises the brain and spinal cord. The neural groove gradually deepens as the neural folds become elevated, and ultimately the folds meet and coalesce in the middle line and convert the groove into a closed tube, the neural tube or neural canal (which strictly speaking is the center of the neural tube), the ectodermal wall of which forms the rudiment of the nervous system. [WP,unvetted]. http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity http://purl.obolibrary.org/obo/BFO_0000040 material entity Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. http://purl.obolibrary.org/obo/UBERON_0001064 ventral pancreatic duct http://purl.obolibrary.org/obo/UBERON_0007329 pancreatic duct A duct joining the pancreas to the common bile duct to supply pancreatic juices which aid in digestion provided by the exocrine pancreas. The pancreatic duct joins the common bile duct just prior to the ampulla of Vater, after which both ducts perforate the medial side of the second portion of the duodenum at the major duodenal papilla. http://purl.obolibrary.org/obo/UBERON_0001088 urine http://purl.obolibrary.org/obo/UBERON_0000174 excreta Excretion that is the output of a kidney http://purl.obolibrary.org/obo/UBERON_0001090 synovial fluid http://purl.obolibrary.org/obo/UBERON_0007794 serous fluid Transudate contained in the synovial cavity of joints, and in the cavity of tendon sheaths and bursae. http://purl.obolibrary.org/obo/UBERON_0001113 lobe of liver http://purl.obolibrary.org/obo/UBERON_0004119 endoderm-derived structure Traditional gross anatomy divided the liver into four lobes based on surface features. The falciform ligament is visible on the front (anterior side) of the liver. This divides the liver into a left anatomical lobe, and a right anatomical lobe. http://purl.obolibrary.org/obo/UBERON_0001114 right lobe of liver http://purl.obolibrary.org/obo/UBERON_0001113 lobe of liver The right lobe is much larger than the left; the proportion between them being as six to one. It occupies the right hypochondrium, and is separated from the left lobe on its upper surface by the falciform ligament; on its under and posterior surfaces by the left sagittal fossa; and in front by the umbilical notch. It is of a somewhat quadrilateral form, its under and posterior surfaces being marked by three fossæ: the porta and the fossæ for the gall-bladder and inferior vena cava, which separate its left part into two smaller lobes; the quadrate and caudate lobes. [WP,unvetted]. http://purl.obolibrary.org/obo/UBERON_0001115 left lobe of liver http://purl.obolibrary.org/obo/UBERON_0001113 lobe of liver The left lobe is smaller and more flattened than the right. It is situated in the epigastric and left hypochondriac regions. Its upper surface is slightly convex and is moulded on to the diaphragm; its under surface presents the gastric impression and omental tuberosity. [WP,unvetted]. http://purl.obolibrary.org/obo/UBERON_0001133 cardiac muscle tissue http://purl.obolibrary.org/obo/UBERON_0010314 structure with developmental contribution from neural crest Muscle tissue composed of cardiac muscle cells, forming the muscles of the heart[ZFA,modified]. http://purl.obolibrary.org/obo/UBERON_0001136 mesothelium http://purl.obolibrary.org/obo/UBERON_0012275 meso-epithelium Simple squamous epithelium of mesodermal origin which lines serous membranes. Examples: mesothelium of pleura, mesothelium of peritoneum[FMA]. http://en.wikipedia.org/wiki/ The mesothelium is a membrane that forms the lining of several body cavities: the pleura (thoracal cavity), peritoneum (abdominal cavity including the mesentery) and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri). http://purl.obolibrary.org/obo/UBERON_0001137 dorsum http://purl.obolibrary.org/obo/UBERON_0000475 organism subdivision A major subdivision of an organism that is the entire part of the organism dorsal to a horizontal plane and bounded on one side by the same transverse plane. In vertebrares this includes the vertebral column.. http://purl.obolibrary.org/obo/UBERON_0001152 cystic duct http://purl.obolibrary.org/obo/UBERON_0003703 extrahepatic bile duct the tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct http://purl.obolibrary.org/obo/UBERON_0001167 wall of stomach http://purl.obolibrary.org/obo/UBERON_0009034 stomach region the layered structure that makes up the stomach, typiclly consists of a serous coat, a muscular coat, a mucous membrane, and other tissue layers in between http://purl.obolibrary.org/obo/UBERON_0001168 wall of small intestine http://purl.obolibrary.org/obo/UBERON_0001262 wall of intestine An anatomical wall that is part of a small intestine [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0001171 portal lobule http://purl.obolibrary.org/obo/UBERON_0009911 lobule The triangular region on the periphery of the liver lobules that contain a bile duct and a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel. http://purl.obolibrary.org/obo/UBERON_0001172 hepatic acinus http://purl.obolibrary.org/obo/UBERON_0011858 acinus of exocrine gland The functional unit of the liver, consisting of a mass of hepatocytes from adjacent liver lobules aligned around the hepatic arterioles and portal venules just as they anastomose into sinusoids. http://purl.obolibrary.org/obo/UBERON_0001175 common hepatic duct http://purl.obolibrary.org/obo/UBERON_0003703 extrahepatic bile duct Predominantly extrahepatic bile duct which is formed by the junction of the right and left hepatic ducts, which are predominantly intrahepatic, and, in turn, joins the cystic duct to form the common bile duct[GAID]. The common hepatic duct is the duct formed by the convergence of the right hepatic duct (which drains bile from the right functional lobe of the liver) and the left hepatic duct (which drains bile from the left functional lobe of the liver). The common hepatic duct then joins the cystic duct coming from the gallbladder to form the common bile duct[WP]. http://purl.obolibrary.org/obo/UBERON_0001176 right hepatic duct http://purl.obolibrary.org/obo/UBERON_0003703 extrahepatic bile duct The duct that drains bile from the right half of the liver and joins the left hepatic duct to form the common hepatic duct. http://purl.obolibrary.org/obo/UBERON_0001177 left hepatic duct http://purl.obolibrary.org/obo/UBERON_0003703 extrahepatic bile duct The duct that drains bile from the left half of the liver and joins the right hepatic duct to form the common hepatic duct. http://purl.obolibrary.org/obo/UBERON_0001193 hepatic artery http://purl.obolibrary.org/obo/UBERON_0001637 artery An artery that supplies the liver. http://purl.obolibrary.org/obo/UBERON_0001199 mucosa of stomach http://purl.obolibrary.org/obo/UBERON_0009034 stomach region The mucosal layer that lines the stomach. http://purl.obolibrary.org/obo/UBERON_0001202 pyloric sphincter http://purl.obolibrary.org/obo/UBERON_0011185 gastrointestinal sphincter A strong ring of smooth muscle at the end of the pyloric canal which lets food pass from the stomach to the duodenum. It receives sympathetic innervation from the celiac ganglion[WP]. http://purl.obolibrary.org/obo/UBERON_0001204 mucosa of small intestine http://purl.obolibrary.org/obo/UBERON_0001242 intestinal mucosa A mucosa that is part of a small intestine [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0001242 intestinal mucosa http://purl.obolibrary.org/obo/UBERON_0004786 gastrointestinal system mucosa The innermost membrane of the four coats of the intestinal wall, the other three being the submucosa, muscular layers, and serosa. (Berk et al., Gastroenterology, 4th ed, v.3, p1479) http://purl.obolibrary.org/obo/UBERON_0001246 interlobular bile duct http://purl.obolibrary.org/obo/UBERON_0003704 intrahepatic bile duct The canals that carry bile in the liver between the intralobular ducts and the biliary ductules; interlobular bile ducts are part of the interlobular portal triad. http://purl.obolibrary.org/obo/UBERON_0001262 wall of intestine http://purl.obolibrary.org/obo/UBERON_0000328 gut wall An anatomical wall that is part of a intestine [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0001263 pancreatic acinus http://purl.obolibrary.org/obo/UBERON_0013232 serous acinus The secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct. http://purl.obolibrary.org/obo/UBERON_0001271 pelvic girdle region http://purl.obolibrary.org/obo/UBERON_0015212 lateral structure The organism subdivision that includes the pelvic girdle skeleton and associated soft tissue. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). Examples: There are only two instances in an organism, right and left pectoral girdle regions. http://purl.obolibrary.org/obo/UBERON_0001276 epithelium of stomach http://purl.obolibrary.org/obo/UBERON_0015833 foregut epithelium The epithelial layer of the stomach . http://purl.obolibrary.org/obo/UBERON_0001279 portal triad http://purl.obolibrary.org/obo/UBERON_0034921 multi organ part structure A multi-organ-part structure that consists of three vessels of the portal lobule including the bile duct, a terminal branch of the hepatic artery and portal vein, and may also include a lymphatic vessel http://purl.obolibrary.org/obo/UBERON_0001280 liver parenchyma http://purl.obolibrary.org/obo/UBERON_0004119 endoderm-derived structure The functional units of the liver including the lobules. http://purl.obolibrary.org/obo/UBERON_0001282 intralobular bile duct http://purl.obolibrary.org/obo/UBERON_0014716 interlobular duct the tubules located between the bile canaliculi and interlobular bile ducts near the outer edge of a classic liver lobule http://purl.obolibrary.org/obo/UBERON_0001353 anal region http://purl.obolibrary.org/obo/UBERON_0000475 organism subdivision The anus and surrounding regions. Encompasses both internal and external regions, where present http://purl.obolibrary.org/obo/UBERON_0001434 skeletal system http://purl.obolibrary.org/obo/UBERON_0011216 organ system subdivision Anatomical system that is a multi-element, multi-tissue anatomical cluster that consists of the skeleton and the articular system. http://purl.obolibrary.org/obo/UBERON_0001441 hindlimb skeleton http://purl.obolibrary.org/obo/UBERON_0007273 pelvic appendage skeleton Subdivision of skeleton consisting of all skeletal elements in an hindlimb region. http://purl.obolibrary.org/obo/UBERON_0001443 chest http://purl.obolibrary.org/obo/UBERON_0009569 subdivision of trunk Subdivision of trunk proper, which is demarcated from the neck by the plane of the superior thoracic aperture and from the abdomen internally by the inferior surface of the diaphragm and externally by the costal margin and associated with the thoracic vertebral column and ribcage and from the back of the thorax by the external surface of the posterolateral part of the rib cage, the anterior surface of the thoracic vertebral column and the posterior axillary lines; together with the abdomen and the perineum, it constitutes the trunk proper[FMA]. http://purl.obolibrary.org/obo/UBERON_0001445 skeleton of pes http://purl.obolibrary.org/obo/UBERON_0006717 autopodial skeleton Subdivision of skeleton that is the collection of all skeletal elements in a pes, which is the distal section of the posterior hindlimb skeleton consisting of the mesopodium, the metapodium and the acropodium (e.g. including the ankle, sole, and toes)[Phenoscape]. http://purl.obolibrary.org/obo/UBERON_0001464 hip http://purl.obolibrary.org/obo/UBERON_0000475 organism subdivision The hip region is located lateral to the gluteal region (i.e. the buttock), inferior to the iliac crest, and overlying the greater trochanter of the thigh bone. In adults, three of the bones of the pelvis have fused into the hip bone which forms part of the hip region. The hip joint, scientifically referred to as the acetabulofemoral joint (art. coxae), is the joint between the femur and acetabulum of the pelvis and its primary function is to support the weight of the body in both static (e.g. standing) and dynamic (e.g. walking or running) postures. [WP,modified]. http://purl.obolibrary.org/obo/UBERON_0001474 bone element http://purl.obolibrary.org/obo/UBERON_0004765 skeletal element Skeletal element that is composed of bone tissue. http://purl.obolibrary.org/obo/UBERON_0001484 articular capsule http://purl.obolibrary.org/obo/UBERON_0000094 membrane organ An articular capsule (or joint capsule) is an envelope surrounding a synovial joint. [WP,unvetted]. http://purl.obolibrary.org/obo/UBERON_0001555 digestive tract http://purl.obolibrary.org/obo/UBERON_0000025 tube A tube extending from the mouth to the anus. http://purl.obolibrary.org/obo/UBERON_0001556 lower urinary tract http://purl.obolibrary.org/obo/UBERON_0000477 anatomical cluster Subdivision of urinary system which consists of the urinary bladder and the urethra. http://purl.obolibrary.org/obo/UBERON_0001605 ciliary muscle http://purl.obolibrary.org/obo/UBERON_0011222 intra-ocular muscle The ciliary muscle is a ring of smooth muscle in the middle layer of the eye that controls the eye's accommodation for viewing objects at varying distances and regulates the flow of aqueous humour through Schlemm's canal. [WP,unvetted]. http://purl.obolibrary.org/obo/UBERON_0001630 muscle organ http://purl.obolibrary.org/obo/UBERON_0005090 muscle structure Organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work[GO]. http://purl.obolibrary.org/obo/UBERON_0001690 ear http://purl.obolibrary.org/obo/UBERON_0010314 structure with developmental contribution from neural crest Sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals. http://purl.obolibrary.org/obo/UBERON_0001714 cranial ganglion http://purl.obolibrary.org/obo/UBERON_0000045 ganglion the groups of nerve cell bodies associated with the twelve cranial nerves http://purl.obolibrary.org/obo/UBERON_0001772 corneal epithelium http://purl.obolibrary.org/obo/UBERON_0015808 eye epithelium the smooth stratified squamous epithelium that covers the outer surface of the cornea http://purl.obolibrary.org/obo/UBERON_0001773 sclera http://purl.obolibrary.org/obo/UBERON_0010313 neural crest-derived structure Opaque fibrous outer layer of the eyeball[ZFA,Kardong,WP]. http://purl.obolibrary.org/obo/UBERON_0001780 spinal nerve http://purl.obolibrary.org/obo/UBERON_0001021 nerve the any of the paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment[MP,modified] http://purl.obolibrary.org/obo/UBERON_0001781 layer of retina http://purl.obolibrary.org/obo/UBERON_0022303 nervous system cell part layer Any of the layers that make up the retina[MP]. http://purl.obolibrary.org/obo/UBERON_0001801 anterior segment of eyeball http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive) http://purl.obolibrary.org/obo/UBERON_0001802 posterior segment of eyeball http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive) http://purl.obolibrary.org/obo/UBERON_0001890 forebrain http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain The most anterior region the brain including both the telencephalon and diencephalon. http://purl.obolibrary.org/obo/UBERON_0001891 midbrain http://purl.obolibrary.org/obo/UBERON_0010314 structure with developmental contribution from neural crest The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO]. http://purl.obolibrary.org/obo/UBERON_0001895 metencephalon http://purl.obolibrary.org/obo/UBERON_0004733 segmental subdivision of hindbrain Rostral segment of the hindbrain that has as its parts the pons (where present) and the cerebellum[WP,modified]. http://purl.obolibrary.org/obo/UBERON_0001896 medulla oblongata http://purl.obolibrary.org/obo/UBERON_0010314 structure with developmental contribution from neural crest Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO]. http://purl.obolibrary.org/obo/UBERON_0001943 midbrain tegmentum http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain Ventral part of the midbrain, separated from the hindbrain by the isthmus[ISBN10:0471888893]. Subdivision of the midbrain lying anterior to the tectum and posterior to the substantia nigra and cerebral peduncle[FMA] The part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds the cerebral aqueduct[WP]. http://purl.obolibrary.org/obo/UBERON_0001969 blood plasma http://purl.obolibrary.org/obo/UBERON_0000179 haemolymphatic fluid The liquid component of blood, in which erythrocytes are suspended. http://purl.obolibrary.org/obo/UBERON_0001970 bile http://purl.obolibrary.org/obo/UBERON_0006314 bodily fluid vital aqueous secretion of the liver that is formed by hepatocytes and modified down stream by absorptive and secretory properties of the bile duct epithelium. http://purl.obolibrary.org/obo/UBERON_0001979 venule http://purl.obolibrary.org/obo/UBERON_0003920 venous blood vessel One of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins http://purl.obolibrary.org/obo/UBERON_0001980 arteriole http://purl.obolibrary.org/obo/UBERON_0003509 arterial blood vessel The smallest division of the artery located between the muscular arteries and the capillaries[GO]. http://purl.obolibrary.org/obo/UBERON_0001981 blood vessel http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure A vessel through which blood circulates in the body. http://purl.obolibrary.org/obo/UBERON_0002017 portal vein http://purl.obolibrary.org/obo/UBERON_0001638 vein A vein that conducts blood from the digestive organs, spleen, pancreas, and gallbladder to the liver[BTO]. http://purl.obolibrary.org/obo/UBERON_0002020 gray matter http://purl.obolibrary.org/obo/UBERON_0011215 central nervous system cell part cluster A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons. http://purl.obolibrary.org/obo/UBERON_0002028 hindbrain http://purl.obolibrary.org/obo/UBERON_0010314 structure with developmental contribution from neural crest The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]. http://purl.obolibrary.org/obo/UBERON_0002036 striated muscle tissue http://purl.obolibrary.org/obo/UBERON_0002385 muscle tissue Muscle tissue that contains fibers that are divided by transverse bands into striations. http://purl.obolibrary.org/obo/UBERON_0002049 vasculature http://purl.obolibrary.org/obo/UBERON_0000477 anatomical cluster An interconnected tubular multi-tissue structure contains fluid that is actively transported around the organism[ZFA]. Examples: vasculature of lung, vasculature of face. http://purl.obolibrary.org/obo/UBERON_0002050 embryonic structure http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure Anatomical structure that is part of an embryo. http://purl.obolibrary.org/obo/UBERON_0002072 hypodermis http://purl.obolibrary.org/obo/UBERON_0013754 integumentary system layer Lowermost layer of the integumentary system in vertebrates. Types of cells that are found in the hypodermis are fibroblasts, adipose cells, and macrophages. It is derived from the mesoderm, but unlike the dermis, it is not derived from the dermatome region of the mesoderm. The hypodermis is used mainly for fat storage[WP]. http://purl.obolibrary.org/obo/UBERON_0002075 viscus http://purl.obolibrary.org/obo/UBERON_0005177 trunk region element An organ that is located within the body cavity (or in its extension, in the scrotum); it consists of organ parts that are embryologically derived from endoderm, splanchnic mesoderm or intermediate mesoderm; together with other organs, the viscus constitutes the respiratory, gastrointestinal, urinary, reproductive and immune systems, or is the central organ of the cardiovascular system. Examples: heart, lung, esophagus, kidney, ovary, spleen. http://purl.obolibrary.org/obo/UBERON_0002082 cardiac ventricle http://purl.obolibrary.org/obo/UBERON_0004151 cardiac chamber Cardiac chamber through which blood leaves the heart. http://purl.obolibrary.org/obo/UBERON_0002084 heart left ventricle http://purl.obolibrary.org/obo/UBERON_0035553 left cardiac chamber A cardiac ventricle that is in the left side of the heart. http://purl.obolibrary.org/obo/UBERON_0002090 postcranial axial skeleton http://purl.obolibrary.org/obo/UBERON_0010912 subdivision of skeleton The post-cranial subdivision of skeleton structural components forming the long axis of the vertebrate body; in Danio, consisting of the notochord, vertebrae, ribs, supraneurals, intermuscular bones, and unpaired median fins; in human consists of the bones of the vertebral column, the thoracic cage and the pelvis[ZFA+FMA]. http://purl.obolibrary.org/obo/UBERON_0002091 appendicular skeleton http://purl.obolibrary.org/obo/UBERON_0010912 subdivision of skeleton Subdivision of skeleton which which consists of all the skeletal elements in in the pectoral and pelvic appendage complexes[cjm]. http://purl.obolibrary.org/obo/UBERON_0002097 skin of body http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure The organ covering the body that consists of the dermis and epidermis. http://purl.obolibrary.org/obo/UBERON_0002100 trunk http://purl.obolibrary.org/obo/UBERON_0011676 subdivision of organism along main body axis Organism subdivision which is the part of the body posterior to the cervical region (or head, when cervical region not present) and anterior to the caudal region. Includes the sacrum when present. http://purl.obolibrary.org/obo/UBERON_0002103 hindlimb http://purl.obolibrary.org/obo/UBERON_0004709 pelvic appendage A (free) limb that is connected to a pelvic girdle region. The extent of this structure includes autopod, stylopod and zeugopod regions when present, but excludes the pelvic girdle and its parts. http://purl.obolibrary.org/obo/UBERON_0002104 visual system http://purl.obolibrary.org/obo/UBERON_0001032 sensory system The sensory system subserving the sense of vision. http://purl.obolibrary.org/obo/UBERON_0002105 vestibulo-auditory system http://purl.obolibrary.org/obo/UBERON_0001032 sensory system Sensory system responsible for the perception of spatial orientation and auditory stimuli. http://purl.obolibrary.org/obo/UBERON_0002120 pronephros http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensible for larval life[GO]. http://purl.obolibrary.org/obo/UBERON_0002167 right lung http://purl.obolibrary.org/obo/UBERON_0002048 lung Lung which consists of the right upper lobe, middle lobe and right lower lobe.[FMA] http://purl.obolibrary.org/obo/UBERON_0002168 left lung http://purl.obolibrary.org/obo/UBERON_0002048 lung Lung which consists of the left upper lobe and left lower lobe.[FMA] http://purl.obolibrary.org/obo/UBERON_0002193 hemolymphoid system http://purl.obolibrary.org/obo/UBERON_0000467 anatomical system Anatomical cluster consisting of the hematopoietic system and the lymphoid system, or its analogs. http://purl.obolibrary.org/obo/UBERON_0002199 integument http://purl.obolibrary.org/obo/UBERON_0011216 organ system subdivision The dermis, epidermis and hypodermis. http://purl.obolibrary.org/obo/UBERON_0002200 vasculature of head http://purl.obolibrary.org/obo/UBERON_0002049 vasculature Vasculature that is part of a head [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0002201 vasculature of trunk http://purl.obolibrary.org/obo/UBERON_0002049 vasculature A vasculature that is part of a trunk [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0002203 vasculature of eye http://purl.obolibrary.org/obo/UBERON_0006876 vasculature of organ Vasculature that is part of the eye region. http://purl.obolibrary.org/obo/UBERON_0002217 synovial joint http://purl.obolibrary.org/obo/UBERON_0000982 skeletal joint Joint in which the articulating bones or cartilages are connected by an articular capsule which encloses a synovial membrane and a synovial cavity. Examples: Temporomandibular joint, knee joint.[FMA] http://purl.obolibrary.org/obo/UBERON_0002224 thoracic cavity http://purl.obolibrary.org/obo/UBERON_0000464 anatomical space The part of the coelemic cavity lumen that is enclosed by the walls of the thorax. http://purl.obolibrary.org/obo/UBERON_0002268 olfactory organ http://purl.obolibrary.org/obo/UBERON_0000020 sense organ An organ that houses olfactory neurons and is responsible for the sense of smell. Examples include the vertebrate nose and the Drosophila dorsal organ. http://purl.obolibrary.org/obo/UBERON_0002294 biliary system http://purl.obolibrary.org/obo/UBERON_0011216 organ system subdivision Organ system subdivision that consists of the organs and ducts that are involved in the production and transportation of bile. In most species this is the gallbladder and the bile ducts (biliary tree). http://purl.obolibrary.org/obo/UBERON_0002308 nucleus of brain http://purl.obolibrary.org/obo/UBERON_0000125 neural nucleus A neural nucleus that is part of the brain. http://purl.obolibrary.org/obo/UBERON_0002323 coelemic cavity lumen http://purl.obolibrary.org/obo/UBERON_0002553 anatomical cavity The cavity within the body of all animals higher than the coelenterates and certain primitive worms, formed by the splitting of the embryonic mesoderm into two layers. In mammals it forms the peritoneal, pleural, and pericardial cavities. http://purl.obolibrary.org/obo/UBERON_0002328 notochord http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure A flexible rod-shaped body found in embryos of all chordates. It is composed of cells derived from the mesoderm and defines the primitive axis of the embryo. In some chordates, it persists throughout life as the main axial support of the body, while in most vertebrates it becomes the nucleus pulposus of the intervertebral disc. The notochord is found ventral to the neural tube. http://purl.obolibrary.org/obo/UBERON_0002329 somite http://purl.obolibrary.org/obo/UBERON_0012275 meso-epithelium Somites are spheres of epithelial cells that form sequentially along the anterior-posterior axis of the embryo through mesenchymal to epithelial transition of the presomitic mesoderm. http://purl.obolibrary.org/obo/UBERON_0002342 neural crest http://purl.obolibrary.org/obo/UBERON_0010316 germ layer / neural crest A specialized region of ectoderm found between the neural ectoderm (neural plate) and non-neural ectoderm and composed of highly migratory pluripotent cells that delaminate in early embryonic development from the dorsal neural tube and give rise to an astounding variety of differentiated cell types[MP]. http://purl.obolibrary.org/obo/UBERON_0002346 neurectoderm http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure Embryonic ectoderm that gives rise to nervous tissue. http://purl.obolibrary.org/obo/UBERON_0002350 conducting system of heart http://purl.obolibrary.org/obo/UBERON_0010131 conducting tissue of heart The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat[GO] http://purl.obolibrary.org/obo/UBERON_0002355 pelvic region of trunk http://purl.obolibrary.org/obo/UBERON_0000475 organism subdivision The lower segment of the trunk, inferioposterior to the abdomen proper, in the transition area between the trunk and the lower limbs. http://purl.obolibrary.org/obo/UBERON_0002360 meninx http://purl.obolibrary.org/obo/UBERON_0010314 structure with developmental contribution from neural crest Membrane organ that surrounds the brain and the spinal cord. http://purl.obolibrary.org/obo/UBERON_0002365 exocrine gland http://purl.obolibrary.org/obo/UBERON_0002530 gland A gland that secretes products (excluding hormones and other chemical messengers) into ducts (duct glands) which lead directly into the external environment[WP]. Typical exocrine glands include sweat glands, salivary glands, mammary glands, stomach, liver, pancreas http://purl.obolibrary.org/obo/UBERON_0002417 abdominal segment of trunk http://purl.obolibrary.org/obo/UBERON_0011676 subdivision of organism along main body axis The abdominal segment of the torso. http://purl.obolibrary.org/obo/UBERON_0002418 cartilage tissue http://purl.obolibrary.org/obo/UBERON_0004755 skeletal tissue Skeletal tissue that is avascular, rich in glycosaminoglycans (GAGs) and typically includes chondrocytes within isolated lacunae. Cartilage tissue is deposited by chondroblasts. http://purl.obolibrary.org/obo/UBERON_0002423 hepatobiliary system http://purl.obolibrary.org/obo/UBERON_0011216 organ system subdivision The part of the digestive system that contains the liver and the biliary system http://purl.obolibrary.org/obo/UBERON_0002428 limb bone http://purl.obolibrary.org/obo/UBERON_0015061 limb endochondral element A bone that is part of a limb [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0002470 autopod region http://purl.obolibrary.org/obo/UBERON_0002529 limb segment Terminal segment of free limb, immediately distal to the zeugopod region. The fully developed autopod consists of the autopod skeleton plus associated structures such as integument, muscle tissue, vasculature etc. The autopod is divided into mesopodial, metapodiual, and acropodial segments. Examples: human hand, mouse paw, human foot http://purl.obolibrary.org/obo/UBERON_0002471 zeugopod http://purl.obolibrary.org/obo/UBERON_0002529 limb segment The middle free limb segment, between the autopod and stylopod segments. Includes as parts the zeugopodial skeleton. Examples: There are two types of zeugopod: forelimb zeugopod (aka forearm), hindlimb zeugopod (aka crus). http://purl.obolibrary.org/obo/UBERON_0002472 stylopod http://purl.obolibrary.org/obo/UBERON_0002529 limb segment The proximal free limb segment. Includes as parts the stylopod skeleton. http://purl.obolibrary.org/obo/UBERON_0002481 bone tissue http://purl.obolibrary.org/obo/UBERON_0004755 skeletal tissue Skeletal tissue with a collagen-rich extracellular matrix vascularized, mineralized with hydroxyapatite and typically including osteocytes located in lacunae that communicate with one another by cell processes (in canaliculi). Bone is deposited by osteoblasts. http://purl.obolibrary.org/obo/UBERON_0002513 endochondral bone http://purl.obolibrary.org/obo/UBERON_0010363 endochondral element Replacement bone that forms within cartilage. http://purl.obolibrary.org/obo/UBERON_0002529 limb segment http://purl.obolibrary.org/obo/UBERON_0010538 paired limb/fin segment A major subdivision of a mature or developing limb, including both skeletal elements (or the mesenchyme that gives rise to the skeletal elements) and associated tissues, such as muscle, connective tissue, integument. Examples: autopod region, zeugopod region, stylopod region, metapodial region, arm region. Excludes the limb girdles. http://purl.obolibrary.org/obo/UBERON_0002530 gland http://purl.obolibrary.org/obo/UBERON_0000062 organ an organ that functions as a secretory or excretory organ http://purl.obolibrary.org/obo/UBERON_0002531 paired fin bud http://purl.obolibrary.org/obo/UBERON_0004357 paired limb/fin bud An outgrowth on the lateral trunk of the embryo that develops into a paired fin. The fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP]. http://purl.obolibrary.org/obo/UBERON_0002532 epiblast (generic) http://purl.obolibrary.org/obo/UBERON_0002050 embryonic structure In amniote animal embryology, the epiblast is a tissue type derived either from the inner cell mass in mammals or the blastodisc in birds and reptiles. It lies above the hypoblast. In mammalian embryogenesis, the columnar cells of the epiblast are adjacent to the trophoblast, while the cuboidal cells of the hypoblast are closer to the blastocoele. The epiblast, whilst referred to as the primary ectoderm, differentiates to form all three layers of the trilaminar germ disc in a process called gastrulation[WP]. The outer of the two layers of the blastoderm that form during gastrulation, corresponding to primitive ectoderm during gastrulation and to the definitive ectoderm after gastrulation[ZFA] http://purl.obolibrary.org/obo/UBERON_0002534 paired fin http://purl.obolibrary.org/obo/UBERON_0008897 fin Fin that is one of a pair located ventrally on the organism. http://purl.obolibrary.org/obo/UBERON_0002539 pharyngeal arch http://purl.obolibrary.org/obo/UBERON_0010314 structure with developmental contribution from neural crest One of a series of paired bulges that develop along the lateral walls of the foregut. The pharyngeal arches have developmental contributions from endoderm, mesoderm, and neural crest cells and are separated by anterior lateral endoderm out-pockets known as pharyngeal pouches. http://purl.obolibrary.org/obo/UBERON_0002544 digit http://purl.obolibrary.org/obo/UBERON_0005881 autopodial extension A subdivision of the autopod that has as part a series of phalanges together with associated vasculature, musculature, integument and nerves. It is continuous with the metapodial subdivision of the autopod, but does not include the metapodials. In species such as humans, fully formed digits are distinct, whereas in other species the digits may be connected by interdigital webbing, or may be completely unseparated (for example, in cetaceans). http://purl.obolibrary.org/obo/UBERON_0002546 cranial placode http://purl.obolibrary.org/obo/UBERON_0005085 ectodermal placode Ectodermal placode that develops in the head into a part of the sensory nervous system. With a few exceptions (lens, adenohypophyseal), cranial placodes are neurogenic. http://purl.obolibrary.org/obo/UBERON_0002553 anatomical cavity http://purl.obolibrary.org/obo/UBERON_0000464 anatomical space Anatomical space which contains portions of one or more body substances and is bounded by the internal surface of one maximally connected anatomical structure. Examples: cranial cavity, pharyngeal recess space, nasal cavity, tooth socket, cavity of serous sac, lumen of stomach, lumen of artery, fornix of vagina. http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia. http://purl.obolibrary.org/obo/UBERON_0003050 olfactory placode http://purl.obolibrary.org/obo/UBERON_0009955 neurogenic placode A thick plate of cells derived from the neural ectoderm in the head region of the embryo that develops into the olfactory region of the nasal cavity. http://purl.obolibrary.org/obo/UBERON_0003052 midbrain-hindbrain boundary http://purl.obolibrary.org/obo/UBERON_0010314 structure with developmental contribution from neural crest The part of the brain that is the morphological boundary between the midbrain and hindbrain and that is the location of an organizing center which patterns the midbrain and hindbrain primordia of the neural plate. http://purl.obolibrary.org/obo/UBERON_0003055 periderm http://purl.obolibrary.org/obo/UBERON_0010371 ecto-epithelium A temporary epithelium that derives from the outer layer of the ectdoerm and is shed once the inner layer differentiates to form a true epidermis. http://purl.obolibrary.org/obo/UBERON_0003056 pre-chordal neural plate http://purl.obolibrary.org/obo/UBERON_0005291 embryonic tissue The portion of neural plate anterior to the mid-hindbrain junction. http://purl.obolibrary.org/obo/UBERON_0003057 chordal neural plate http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure The portion of neural plate posterior to the mid-hindbrain junction. http://purl.obolibrary.org/obo/UBERON_0003059 presomitic mesoderm http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure Unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form. http://purl.obolibrary.org/obo/UBERON_0003060 pronephric duct http://purl.obolibrary.org/obo/UBERON_0012275 meso-epithelium In mammals, the pronephric duct is the predecessor of the Wolffian duct[WP]. http://purl.obolibrary.org/obo/UBERON_0003061 blood island http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure Blood islands are structures in the developing embryo which lead to many different parts of the circulatory system. They primarily derive from plexuses formed from angioblasts. Within them, vacuoles appear through liquefaction of the central part of the syncytium into plasma. The lumen of the blood vessels thus formed is probably intracellular. The flattened cells at the periphery form the endothelium. The nucleated red blood corpuscles develop either from small masses of the original angioblast left attached to the inner wall of the lumen or directly from the flat endothelial cells. In either case the syncytial mass thus formed projects from and is attached to the wall of the vessel. Such a mass is known as a blood island and hemoglobin gradually accumulates within it. Later the cells on the surface round up, giving the mass a mulberry-like appearance. Then the red blood cells break loose and are carried away in the plasma. Such free blood cells continue to divide. Blood islands have been seen in the area vasculosa in the omphalomesenteric vein and arteries, and in the dorsal aorta[WP, unvetted]. http://purl.obolibrary.org/obo/UBERON_0003064 intermediate mesoderm http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure The intermediate mesoderm is located between the lateral mesoderm and the paraxial mesoderm. It develops into the kidney and gonads. http://purl.obolibrary.org/obo/UBERON_0003066 pharyngeal arch 2 http://purl.obolibrary.org/obo/UBERON_0002539 pharyngeal arch The second pharyngeal arch will form the hyoid apparatus. The cranial neural crest cells that populate the second pharyngeal arch emerge primarily from rhombomere 4 and will form skeletal elements. http://purl.obolibrary.org/obo/UBERON_0003068 axial mesoderm http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure The axial mesoderm includes the prechordal mesoderm and the chordamesoderm. It gives rise to the prechordal plate and to the notochord. http://purl.obolibrary.org/obo/UBERON_0003072 optic cup http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure Multi-tissue structure that is comprised of neural and non-neural epithelial layers which will form the retina and retinal pigmented epithelium of the mature eye[ZFA]. double walled structured formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and sensory layers of the retina while the mouth of the optic cup eventually forms the pupil of the eye[MP]. http://purl.obolibrary.org/obo/UBERON_0003073 lens placode http://purl.obolibrary.org/obo/UBERON_0011814 non-neurogenic ectodermal placode A thickened portion of ectoderm which serves as the precursor to the lens. SOX2 and Pou2f1 are involved in its development[WP]. http://purl.obolibrary.org/obo/UBERON_0003075 neural plate http://purl.obolibrary.org/obo/UBERON_0016879 future central nervous system A region of embryonic ectodermal cells that lie directly above the notochord. During neurulation, they change shape and produce an infolding of the neural plate (the neural fold) that then seals to form the neural tube[XAO]. The earliest recognizable dorsal ectodermal primordium of the central nervous system present near the end of gastrulation before infolding to form the neural keel; consists of a thickened pseudostratified epithelium[ZFA] http://purl.obolibrary.org/obo/UBERON_0003077 paraxial mesoderm http://purl.obolibrary.org/obo/UBERON_0015212 lateral structure The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube[GO] http://purl.obolibrary.org/obo/UBERON_0003081 lateral plate mesoderm http://purl.obolibrary.org/obo/UBERON_0007524 dense mesenchyme tissue Portion of the middle of the three primary germ layers of the embryo that resides on the periphery of the embryo, is continuous with the extra-embryonic mesoderm, splits into two layers enclosing the intra-embryonic coelom, and gives rise to body wall structures[MP]. http://purl.obolibrary.org/obo/UBERON_0003082 myotome http://purl.obolibrary.org/obo/UBERON_0017650 developing mesenchymal structure A transitional population of migrating mesenchymal cells that derive from somites and that will become muscle cells. http://purl.obolibrary.org/obo/UBERON_0003084 heart primordium http://purl.obolibrary.org/obo/UBERON_0001048 primordium Bilateral groups of cells consisting of three rows: one row of endocardial precursors medially and two rows of myocardical precursors laterally. The two populations fuse at the midline to form the heart rudiment or cone. http://purl.obolibrary.org/obo/UBERON_0003089 sclerotome http://purl.obolibrary.org/obo/UBERON_0007530 migrating mesenchyme population Ventral somitic compartment that is a precursor of the axial skeleton[XAO]. Sclerotomes eventually differentiate into the vertebrae and most of the skull. The caudal (posterior) half of one sclerotome fuses with the rostral (anterior) half of the adjacent one to form each vertebra. From their initial location within the somite, the sclerotome cells migrate medially towards the notochord. These cells meet the sclerotome cells from the other side to form the vertebral body. From this vertebral body, sclerotome cells move dorsally and surround the developing spinal cord, forming the vertebral arch[WP]. http://purl.obolibrary.org/obo/UBERON_0003091 thyroid primordium http://purl.obolibrary.org/obo/UBERON_0004119 endoderm-derived structure The initial thyroid precursor, the thyroid primordium, starts as a simple midline thickening and develops to form the thyroid diverticulum. This structure is initially hollow, although it later solidifies and becomes bilobed. The 2 lobes are located on either side of the midline and are connected via an isthmus. http://purl.obolibrary.org/obo/UBERON_0003099 cranial neural crest http://purl.obolibrary.org/obo/UBERON_0010314 structure with developmental contribution from neural crest neural crest cells (NCCs) originating in the anterior part of the developing embryo and residing between the mid-diencephalon and the forming hindbrain; cranial NCCs migrate dorsolaterally to form the craniofacial mesenchyme that differentiates into various craniofacial cartilages and bones, cranial neurons, glia, and connective tissues of the face; these cells enter the pharyngeal pouches and arches where they give rise to thymic cells, bones of the middle ear and jaw (mandible), and the odontoblasts of the tooth primordia; like their counterparts in the trunk, cranial NCCs also contribute to the developing peripheral nervous system, along with the pigmented cell (i.e. melanocyte) lineage. http://purl.obolibrary.org/obo/UBERON_0003100 female organism http://purl.obolibrary.org/obo/UBERON_0000468 multicellular organism Gonochoristic organism that can produce female gametes. http://purl.obolibrary.org/obo/UBERON_0003101 male organism http://purl.obolibrary.org/obo/UBERON_0000468 multicellular organism Gonochoristic organism that can produce male gametes. http://purl.obolibrary.org/obo/UBERON_0003102 surface structure http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure Anatomical structure that overlaps the outer epithelial layer and is adjacent to the space surrounding the organism. http://purl.obolibrary.org/obo/UBERON_0003103 compound organ http://purl.obolibrary.org/obo/UBERON_0000062 organ Anatomical structure that has as its parts two or more multi-tissue structures of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona fide boundaries from other distinct anatomical structures of different types. http://purl.obolibrary.org/obo/UBERON_0003104 mesenchyme http://purl.obolibrary.org/obo/UBERON_0000479 tissue Portion of tissue consisting of loosely organized undifferentiated mesodermal cells that give rise to such structures as connective tissues, blood, lymphatics, bone, and cartilage[XAO]. A mesh-like cell arrangement, less compact than an epithelium[ZFA]. The part of the embryonic mesoderm, consisting of loosely packed, unspecialized cells set in a gelatinous ground substance, from which connective tissue, bone, cartilage, and the circulatory and lymphatic systems develop[BTO]. http://purl.obolibrary.org/obo/UBERON_0003114 pharyngeal arch 3 http://purl.obolibrary.org/obo/UBERON_0002539 pharyngeal arch The third branchial arch contributes to the development of the hyoid bone, stylopharyngeus muscle, inferior parathyroid gland, and thymus. http://purl.obolibrary.org/obo/UBERON_0003117 pharyngeal arch 6 http://purl.obolibrary.org/obo/UBERON_0002539 pharyngeal arch The 6th pharyngeal arch. contributes to the development of the sternocleidomastoid and trapezius muscles http://purl.obolibrary.org/obo/UBERON_0003220 metanephric mesenchyme http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure one of the two embryological structures that give rise to the kidney (the other is the ureteric bud). The metanephric blastema mostly develops into nephrons, but can also form parts of the collecting duct system.[WP]. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros[GO] http://purl.obolibrary.org/obo/UBERON_0003258 endoderm of foregut http://purl.obolibrary.org/obo/UBERON_0015833 foregut epithelium An endoderm that is part of a foregut [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0003294 gland of foregut http://purl.obolibrary.org/obo/UBERON_0003408 gland of gut A gland that is part of a foregut [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0003314 eye mesenchyme http://purl.obolibrary.org/obo/UBERON_0010312 immature eye Mesenchyme that is part of a developing camera-type eye. http://purl.obolibrary.org/obo/UBERON_0003350 epithelium of mucosa http://purl.obolibrary.org/obo/UBERON_0000483 epithelium A layer of epithelial cells on the surface of the mucosa. http://purl.obolibrary.org/obo/UBERON_0003353 epithelium of hindgut http://purl.obolibrary.org/obo/UBERON_0003929 digestive tract epithelium An epithelium that is part of a hindgut [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0003386 smooth muscle of eye http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure any of the striated muscles that move the eye and include: superior rectus, inferior rectus, medial rectus, lateral rectus, superior oblique, inferior oblique, retractor bulbi http://purl.obolibrary.org/obo/UBERON_0003408 gland of gut http://purl.obolibrary.org/obo/UBERON_0013765 digestive system element A gland that is part of a digestive tract [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0003412 pelvic appendage bud mesenchyme http://purl.obolibrary.org/obo/UBERON_0010329 paired limb/fin bud mesenchyme Mesenchyme that is part of a pelvic appendage bud. http://purl.obolibrary.org/obo/UBERON_0003479 thoracic cavity vein http://purl.obolibrary.org/obo/UBERON_0003519 thoracic cavity blood vessel A vein that is part of a thoracic cavity [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0003498 heart blood vessel http://purl.obolibrary.org/obo/UBERON_0005985 coronary vessel A blood vessel that is part of a heart [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0003509 arterial blood vessel http://purl.obolibrary.org/obo/UBERON_0001981 blood vessel A blood vessel that is part of the arterial system. Includes artery, arteriole and aorta. http://purl.obolibrary.org/obo/UBERON_0003513 trunk blood vessel http://purl.obolibrary.org/obo/UBERON_0001981 blood vessel A blood vessel that is part of a trunk [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0003519 thoracic cavity blood vessel http://purl.obolibrary.org/obo/UBERON_0001981 blood vessel A blood vessel that is part of a thoracic cavity [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0003528 brain gray matter http://purl.obolibrary.org/obo/UBERON_0002020 gray matter A gray matter that is part of a brain [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0003606 limb long bone http://purl.obolibrary.org/obo/UBERON_0002428 limb bone A long bone that is part of a limb [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0003657 limb joint http://purl.obolibrary.org/obo/UBERON_0000982 skeletal joint Any joint that is part of a (free) limb. http://purl.obolibrary.org/obo/UBERON_0003714 neural tissue http://purl.obolibrary.org/obo/UBERON_0000479 tissue Portion of tissue in the nervous system which consists of neurons and glial cells, and may also contain parts of the vasculature. http://purl.obolibrary.org/obo/UBERON_0003716 recurrent laryngeal nerve http://purl.obolibrary.org/obo/UBERON_0011779 nerve of head region A branch of the vagus nerve that supplies motor function and sensation to the larynx (voice box). It travels within the endoneurium. It is the nerve of the 6th Branchial Arch. http://purl.obolibrary.org/obo/UBERON_0003820 prostate bud http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure A region of the fetal urogenital sinus epithelium destined to become the prostate[GO]. http://purl.obolibrary.org/obo/UBERON_0003821 metapodium bone http://purl.obolibrary.org/obo/UBERON_0012357 digitopodium bone A bone of the metapodial skeleton http://purl.obolibrary.org/obo/UBERON_0003834 thoracic segment blood vessel http://purl.obolibrary.org/obo/UBERON_0003513 trunk blood vessel A blood vessel that is part of a thorax [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0003841 autopod joint http://purl.obolibrary.org/obo/UBERON_0003657 limb joint A limb joint that is part of an autopod [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0003842 neural tube lumen http://purl.obolibrary.org/obo/UBERON_0000464 anatomical space An anatomical space that surrounded_by a neural tube. http://purl.obolibrary.org/obo/UBERON_0003849 mesencephalic neural crest http://purl.obolibrary.org/obo/UBERON_0003099 cranial neural crest A neural crest that has_potential_to_developmentally_contribute_to a midbrain. http://purl.obolibrary.org/obo/UBERON_0003850 telencephalon neural crest http://purl.obolibrary.org/obo/UBERON_0002342 neural crest A neural crest that has_potential_to_developmentally_contribute_to a telencephalon. http://purl.obolibrary.org/obo/UBERON_0003852 rhombencephalon neural crest http://purl.obolibrary.org/obo/UBERON_0003099 cranial neural crest A neural crest that has_potential_to_developmentally_contribute_to a hindbrain. http://purl.obolibrary.org/obo/UBERON_0003853 spinal cord neural crest http://purl.obolibrary.org/obo/UBERON_0002342 neural crest A neural crest that has_potential_to_developmentally_contribute_to a spinal cord. http://purl.obolibrary.org/obo/UBERON_0003869 presumptive ganglion http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure A presumptive structure that has the potential to develop into a ganglion. http://purl.obolibrary.org/obo/UBERON_0003886 future coelemic cavity lumen http://purl.obolibrary.org/obo/UBERON_0000464 anatomical space An anatomical cavity that has the potential to develop into a coelemic cavity lumen. http://purl.obolibrary.org/obo/UBERON_0003887 intraembryonic coelom http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure The part of the coelom in the embryo between the somatopleuric and splanchnopleuric mesoderm; the principal body cavities of the trunk (thoracic, abdominal, and pelvic) arise from this embryonic part of the coelom http://purl.obolibrary.org/obo/UBERON_0003894 liver primordium http://purl.obolibrary.org/obo/UBERON_0009497 epithelium of foregut-midgut junction A small endodermal thickening in the foregut adjacent to the transverse septum. Invaginates forming the hepatic diverticulum. http://purl.obolibrary.org/obo/UBERON_0003902 retinal neural layer http://purl.obolibrary.org/obo/UBERON_0001781 layer of retina The part of the retina that contains neurons and photoreceptor cells[GO]. http://purl.obolibrary.org/obo/UBERON_0003914 epithelial tube http://purl.obolibrary.org/obo/UBERON_0000483 epithelium Epithelial tubes transport gases, liquids and cells from one site to another and form the basic structure of many organs and tissues, with tube shape and organization varying from the single-celled excretory organ in Caenorhabditis elegans to the branching trees of the mammalian kidney and insect tracheal system. http://purl.obolibrary.org/obo/UBERON_0003918 kidney mesenchyme http://purl.obolibrary.org/obo/UBERON_0003104 mesenchyme Kidney mesenchyme is the tissue made up of loosely connected mesenchymal cells in the kidney[GO]. http://purl.obolibrary.org/obo/UBERON_0003920 venous blood vessel http://purl.obolibrary.org/obo/UBERON_0001981 blood vessel A blood vessel that carries blood from the capillaries toward the heart http://purl.obolibrary.org/obo/UBERON_0003921 pancreas primordium http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure embryonic structure that develops into pancreatic bud. http://purl.obolibrary.org/obo/UBERON_0003922 pancreatic epithelial bud http://purl.obolibrary.org/obo/UBERON_0007499 epithelial sac The embryonic pancreas develops from two separate anlagen in the foregut epithelium, one dorsal and two ventral pancreatic buds[PMID]. http://purl.obolibrary.org/obo/UBERON_0003923 dorsal pancreatic bud http://purl.obolibrary.org/obo/UBERON_0003922 pancreatic epithelial bud pancreatic bud that gives rise to the accessory pancreatic duct. http://purl.obolibrary.org/obo/UBERON_0003924 ventral pancreatic bud http://purl.obolibrary.org/obo/UBERON_0003922 pancreatic epithelial bud pancreatic bud that gives rise to the major pancreatic duct. http://purl.obolibrary.org/obo/UBERON_0003928 digestive system duct http://purl.obolibrary.org/obo/UBERON_0000058 duct A duct that is part of a digestive system [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0003929 digestive tract epithelium http://purl.obolibrary.org/obo/UBERON_0000483 epithelium An epithelium that lines the lumen of the digestive tract. http://purl.obolibrary.org/obo/UBERON_0003937 sex gland http://purl.obolibrary.org/obo/UBERON_0005156 reproductive structure Any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction. http://purl.obolibrary.org/obo/UBERON_0003975 internal female genitalia http://purl.obolibrary.org/obo/UBERON_0004175 internal genitalia The internal feminine genital organs, including the ovaries, uterine tubes, uterus, uterine cervix, and vagina. http://purl.obolibrary.org/obo/UBERON_0004016 dermatome http://purl.obolibrary.org/obo/UBERON_0017650 developing mesenchymal structure A transitional population of migrating mesenchymal cells that derive from somites and that will become dermal cells. http://purl.obolibrary.org/obo/UBERON_0004022 germinal neuroepithelium http://purl.obolibrary.org/obo/UBERON_0034706 proliferating neuroepithelium The single layer of epithelial cells that lines the early neural tube and develops into the nervous system and into the neural crest cells http://purl.obolibrary.org/obo/UBERON_0004058 biliary ductule http://purl.obolibrary.org/obo/UBERON_0004119 endoderm-derived structure One of the fine terminal elements of the bile duct system, leaving the portal canal, and pursuing a course at the periphery of a lobule of the liver[BTO]. the excretory ducts of the liver that connect the interlobular ductules to the right or left hepatic duct[MP] http://purl.obolibrary.org/obo/UBERON_0004060 neural tube ventricular layer http://purl.obolibrary.org/obo/UBERON_0034706 proliferating neuroepithelium The layer of undifferentiated, proliferating cells that line the neural tube lumen that is the immediate transformation of the germinal neuroepithelium http://purl.obolibrary.org/obo/UBERON_0004061 neural tube mantle layer http://purl.obolibrary.org/obo/UBERON_0034707 differentiating neuroepithelium The layer of glia and differentiating neurons that forms as a second layer around the germinal neuroepithium; as this develops it comes to lie between the ventricular and marginal layers and includes the basal and alar plates. Develops into neurons and glia forming a gray matter layer. http://purl.obolibrary.org/obo/UBERON_0004062 neural tube marginal layer http://purl.obolibrary.org/obo/UBERON_0005162 multi cell part structure The outermost layer of the neural tube that consists of axons from the developing mantle layer and will form the white matter http://purl.obolibrary.org/obo/UBERON_0004064 neural tube basal plate http://purl.obolibrary.org/obo/UBERON_0005291 embryonic tissue The region of the mantle layer of the neural tube that lies ventral to the sulcus limitans and contains primarily motor neurons and interneurons. http://purl.obolibrary.org/obo/UBERON_0004087 vena cava http://purl.obolibrary.org/obo/UBERON_0013768 great vessel of heart Any of the veins that carries deoxygenated blood from a part of the body into the right atrium of the heart. http://purl.obolibrary.org/obo/UBERON_0004088 orbital region http://purl.obolibrary.org/obo/UBERON_0001444 subdivision of head The subdivision of the face that includes the eye (eyeball plus adnexa such as eyelids) and the orbit of the skull and associated parts of the face such as the eyebrows, if present http://purl.obolibrary.org/obo/UBERON_0004111 anatomical conduit http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure Any tube, opening or passage that connects two distinct anatomical spaces. http://purl.obolibrary.org/obo/UBERON_0004119 endoderm-derived structure http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure An anatomical structure that develops (entirely or partially) from the endoderm. http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure An anatomical structure that develops (entirely or partially) from the mesoderm. http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure An anatomical structure that develops (entirely or partially) from the ectoderm. http://purl.obolibrary.org/obo/UBERON_0004122 genitourinary system http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure Anatomical system that has as its parts the organs concerned with the production and excretion of urine and those concerned with reproduction. http://purl.obolibrary.org/obo/UBERON_0004128 optic vesicle http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup[GO]. Portion of tissue that is comprised of neuroepitheium which has pinched off from the anterior neural keel and will form the optic cup[ZFA]. http://purl.obolibrary.org/obo/UBERON_0004139 cardiogenic plate http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure The first recognizable structure derived from the heart field http://purl.obolibrary.org/obo/UBERON_0004140 primary heart field http://purl.obolibrary.org/obo/UBERON_0007688 anlage A specific region of the lateral mesoderm that will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle. http://purl.obolibrary.org/obo/UBERON_0004141 heart tube http://purl.obolibrary.org/obo/UBERON_0012275 meso-epithelium An epithelial tube that will give rise to the mature heart. http://purl.obolibrary.org/obo/UBERON_0004151 cardiac chamber http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure A cardiac chamber surrounds an enclosed cavity within the heart http://purl.obolibrary.org/obo/UBERON_0004161 septum transversum http://purl.obolibrary.org/obo/UBERON_0003104 mesenchyme A thick plate of mesodermal tissue that occupies the space between the thoracic cavity and yolk stalk in the early embryo, forming a transverse partition partially separating the coelomic cavity into thoracic and abdominal portions. It gives rise to the central tendon of the diaphragm[VHOG]. http://purl.obolibrary.org/obo/UBERON_0004175 internal genitalia http://purl.obolibrary.org/obo/UBERON_0003133 reproductive organ The internal genitalia are the internal sex organs such as the uterine tube, the uterus and the vagina in female mammals, and the testis, seminal vesicle, ejaculatory duct and prostate in male mammals http://purl.obolibrary.org/obo/UBERON_0004176 external genitalia http://purl.obolibrary.org/obo/UBERON_0003133 reproductive organ The external genitalia are the outer sex organs, such as the penis or vulva in mammals http://purl.obolibrary.org/obo/UBERON_0004185 endodermal part of digestive tract http://purl.obolibrary.org/obo/UBERON_0004921 subdivision of digestive tract A portions of the gut that is derived from endoderm. http://purl.obolibrary.org/obo/UBERON_0004277 eye muscle http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure A muscle that is part of the eye region. http://purl.obolibrary.org/obo/UBERON_0004288 skeleton http://purl.obolibrary.org/obo/UBERON_0034925 anatomical collection Anatomical cluster that consists of all the skeletal elements (eg., bone, cartilage, and teeth) of the body. http://purl.obolibrary.org/obo/UBERON_0004290 dermomyotome http://purl.obolibrary.org/obo/UBERON_0016888 transitional anatomical structure The bilaminar epithelium formed from the myotome and dermatome. http://purl.obolibrary.org/obo/UBERON_0004291 heart rudiment http://purl.obolibrary.org/obo/UBERON_0012275 meso-epithelium A cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube. http://purl.obolibrary.org/obo/UBERON_0004300 distal phalanx http://purl.obolibrary.org/obo/UBERON_0003221 phalanx Distal-most phalanx within a digit. http://purl.obolibrary.org/obo/UBERON_0004301 middle phalanx http://purl.obolibrary.org/obo/UBERON_0003221 phalanx A phalanx located between proximal and distal phalanges. http://purl.obolibrary.org/obo/UBERON_0004302 proximal phalanx http://purl.obolibrary.org/obo/UBERON_0003221 phalanx Proximal-most phalanx within a digit. http://purl.obolibrary.org/obo/UBERON_0004341 primitive streak http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure The primitive streak is a structure that forms during the early stages of avian, reptilian and mammalian embryonic development[WP]. the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm[MP] http://purl.obolibrary.org/obo/UBERON_0004347 limb bud http://purl.obolibrary.org/obo/UBERON_0004357 paired limb/fin bud An outgrowth on the lateral trunk of the embryo that develops into a limb. The limb bud is divided into ectoderm and mesenchyme[cjm, modified from MP]. http://purl.obolibrary.org/obo/UBERON_0004348 optic eminence http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure The embryonic structure that gives rise to the corneal ectoderm http://purl.obolibrary.org/obo/UBERON_0004356 apical ectodermal ridge http://purl.obolibrary.org/obo/UBERON_0002050 embryonic structure multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]. http://purl.obolibrary.org/obo/UBERON_0004357 paired limb/fin bud http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure An outgrowth on the lateral trunk of the embryo that develops into a limb or paired fin. The limb/fin bud is divided into ectoderm and mesenchyme[cjm, modified from MP]. http://purl.obolibrary.org/obo/UBERON_0004370 anterior limiting lamina of cornea http://purl.obolibrary.org/obo/UBERON_0010313 neural crest-derived structure A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; it is considered to be a basement membrane. http://purl.obolibrary.org/obo/UBERON_0004375 bone of free limb or fin http://purl.obolibrary.org/obo/UBERON_0010740 bone of appendage girdle complex A bone that is part of an appendage [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0004381 skeleton of limb http://purl.obolibrary.org/obo/UBERON_0011582 paired limb/fin skeleton The collection of all skeletal elements in an individual limb. http://purl.obolibrary.org/obo/UBERON_0004456 entire sense organ system http://purl.obolibrary.org/obo/UBERON_0000467 anatomical system Sum of all sensory systems in an organism. http://purl.obolibrary.org/obo/UBERON_0004493 cardiac muscle tissue of myocardium http://purl.obolibrary.org/obo/UBERON_0001133 cardiac muscle tissue A portion of cardiac muscle tissue that is part of a myocardium [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0004529 anatomical projection http://purl.obolibrary.org/obo/UBERON_0034768 morphological feature A projection or outgrowth of tissue from a larger body or organ. http://purl.obolibrary.org/obo/UBERON_0004537 blood vasculature http://purl.obolibrary.org/obo/UBERON_0002049 vasculature A vascular network consisting of blood vessels. http://purl.obolibrary.org/obo/UBERON_0004571 systemic arterial system http://purl.obolibrary.org/obo/UBERON_0007798 vascular system The part of the arterial system which carries oxygenated blood away from the heart to the body, and returns deoxygenated blood back to the heart. http://purl.obolibrary.org/obo/UBERON_0004572 arterial system http://purl.obolibrary.org/obo/UBERON_0007798 vascular system The part of the cardiovascular system consisting of all arteries. http://purl.obolibrary.org/obo/UBERON_0004573 systemic artery http://purl.obolibrary.org/obo/UBERON_0001637 artery An artery of the systemic circulation, which is the part of the cardiovascular system which carries oxygenated blood away from the heart, to the body, and returns deoxygenated blood back to the heart. http://purl.obolibrary.org/obo/UBERON_0004582 venous system http://purl.obolibrary.org/obo/UBERON_0007798 vascular system The part of the cardiovascular system consisting of all venous vessels. In vertebrates with a double circulation, this can be divided into systemic and pulmonary portions. http://purl.obolibrary.org/obo/UBERON_0004590 sphincter muscle http://purl.obolibrary.org/obo/UBERON_0001630 muscle organ A structure, usually a circular muscle, that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning. http://purl.obolibrary.org/obo/UBERON_0004647 liver lobule http://purl.obolibrary.org/obo/UBERON_0004119 endoderm-derived structure the polygonal structure of the liver that consists of hepatocytes radiating outward from a hepatic vein http://purl.obolibrary.org/obo/UBERON_0004708 paired limb/fin http://purl.obolibrary.org/obo/UBERON_0000026 appendage An appendage that is part of a appendage girdle complex. http://purl.obolibrary.org/obo/UBERON_0004709 pelvic appendage http://purl.obolibrary.org/obo/UBERON_0004708 paired limb/fin Paired appendage that consists of the posterior appendicular skeleton and associated soft and hard tissues, but excludes the pelvic girdle and its associated soft and hard tissues. http://purl.obolibrary.org/obo/UBERON_0004716 conceptus http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i.e. the products of conception) The conceptus includes all structures that develop from the zygote, both embryonic and extraembryonic. It includes the embryo as well as the embryonic part of the placenta and its associated membranes - amnion, chorion (gestational sac), and yolk sac[WP]. http://purl.obolibrary.org/obo/UBERON_0004732 segmental subdivision of nervous system http://purl.obolibrary.org/obo/UBERON_0000063 organ subunit Any segmental subdivision of a nervous system. Includes metameric developmental segments, such as vertebrates neuromeres. http://purl.obolibrary.org/obo/UBERON_0004733 segmental subdivision of hindbrain http://purl.obolibrary.org/obo/UBERON_0010314 structure with developmental contribution from neural crest An organ subunit that is part of a hindbrain [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0004734 gastrula http://purl.obolibrary.org/obo/UBERON_0000922 embryo Organism at the gastrula stage. http://purl.obolibrary.org/obo/UBERON_0004755 skeletal tissue http://purl.obolibrary.org/obo/UBERON_0002384 connective tissue A specialized form of connective tissue in which the extracellular matrix is firm, providing the tissue with resilience, and/or mineralized and that functions in mechanical and structural support.[VSAO] http://purl.obolibrary.org/obo/UBERON_0004765 skeletal element http://purl.obolibrary.org/obo/UBERON_0000062 organ Organ consisting of skeletal tissue. Encompasses whole bones, fused bones, cartilaginious elements, teeth, dermal denticles. http://purl.obolibrary.org/obo/UBERON_0004770 articular system http://purl.obolibrary.org/obo/UBERON_0034925 anatomical collection Anatomical system that consists of all the joints of the body. http://purl.obolibrary.org/obo/UBERON_0004786 gastrointestinal system mucosa http://purl.obolibrary.org/obo/UBERON_0000344 mucosa A mucosa that is part of a gastrointestinal system. http://purl.obolibrary.org/obo/UBERON_0004802 respiratory tract epithelium http://purl.obolibrary.org/obo/UBERON_0010499 pseudostratified ciliated columnar epithelium the pseudostratified ciliated epithelium that lines much of the conducting portion of the airway, including part of the nasal cavity and larynx, the trachea, and bronchi http://purl.obolibrary.org/obo/UBERON_0004807 respiratory system epithelium http://purl.obolibrary.org/obo/UBERON_0000483 epithelium An epithelium that is part of a respiratory system [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0004808 gastrointestinal system epithelium http://purl.obolibrary.org/obo/UBERON_0000483 epithelium An epithelium that is part of a digestive system [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0004814 upper respiratory tract epithelium http://purl.obolibrary.org/obo/UBERON_0004802 respiratory tract epithelium An epithelium that is part of a upper respiratory tract [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0004819 kidney epithelium http://purl.obolibrary.org/obo/UBERON_0000483 epithelium the cellular avascular layer of the kidney luminar surfaces http://purl.obolibrary.org/obo/UBERON_0004872 splanchnic layer of lateral plate mesoderm http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure Layer of lateral plate mesoderm that forms the circulatory system and future gut wall - overlies endoderm[WP]. http://purl.obolibrary.org/obo/UBERON_0004874 somatopleure http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure A structure created during embryogenesis when the lateral mesoderm splits into two layers - the outer (or somatic) layer becomes applied to the inner surface of the ectoderm, and with it forms the somatopleure.[WP]. http://purl.obolibrary.org/obo/UBERON_0004875 nephrogenic cord http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure A portion of the urogenital ridge which is the source of much of the urinary system[WP]. http://purl.obolibrary.org/obo/UBERON_0004876 urogenital fold http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure One of of the pair of folds derived from the cloacal folds which give rise to a portion of the external genitalia; in male embryos they close over the urethral plate and fuse to form the spongy (penile) urethra and ventral aspect of the penis, not including the glans; failure of fusion of the urethral folds leads to hypospadias; in female embryos they fuse only anterior to the anus and form the labia minora[MP]. http://purl.obolibrary.org/obo/UBERON_0004880 chordamesoderm http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure The central region of trunk mesoderm. This tissue forms the notochord http://purl.obolibrary.org/obo/UBERON_0004902 urogenital sinus epithelium http://purl.obolibrary.org/obo/UBERON_0009846 embryonic cloacal epithelium The fetal urogenital sinus (from which the prostate derives) is a simple cylinder of stratified basal epithelium, surrounded by mesenchyme and positioned between the embryonic bladder and pelvic urethra http://purl.obolibrary.org/obo/UBERON_0004905 articulation http://purl.obolibrary.org/obo/UBERON_0034921 multi organ part structure Anatomical cluster that connects two or more adjacent skeletal elements or hardened body parts. http://purl.obolibrary.org/obo/UBERON_0004907 lower digestive tract http://purl.obolibrary.org/obo/UBERON_0004921 subdivision of digestive tract The region of the digestive tract extending from the beginning of the intestines to the anus[GO - gut definition]. http://purl.obolibrary.org/obo/UBERON_0004908 upper digestive tract http://purl.obolibrary.org/obo/UBERON_0004921 subdivision of digestive tract The region of the digestive tract extending from the mouth cavity through pharynx esophagus stomach and duodenum. http://purl.obolibrary.org/obo/UBERON_0004914 duodenal papilla http://purl.obolibrary.org/obo/UBERON_0034944 zone of organ One of the two small elevations on the mucosa of the duodenum, the major at the entrance of the conjoined pancreatic and common bile ducts and the minor at the entrance of the accessory pancreatic duct. http://purl.obolibrary.org/obo/UBERON_0004921 subdivision of digestive tract http://purl.obolibrary.org/obo/UBERON_0013522 subdivision of tube A proximal-distal subdivision of the digestive tract. http://purl.obolibrary.org/obo/UBERON_0004923 organ component layer http://purl.obolibrary.org/obo/UBERON_0000064 organ part A part of a wall of an organ that forms a layer. http://purl.obolibrary.org/obo/UBERON_0004998 mucosa of pylorus http://purl.obolibrary.org/obo/UBERON_0001199 mucosa of stomach A mucosa that is part of a pylorus [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0005061 neural groove http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure The median dorsal longitudinal groove formed in the embryo by the neural plate after the appearance of the neural folds. http://purl.obolibrary.org/obo/UBERON_0005062 neural fold http://purl.obolibrary.org/obo/UBERON_0015212 lateral structure One of the two elevated edges of the neural groove[GO,MP]. http://purl.obolibrary.org/obo/UBERON_0005068 neural rod http://purl.obolibrary.org/obo/UBERON_0016879 future central nervous system A solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts[GO]. An intermediate stage in the development of the central nervous system present during the segmentation period; the neural rod is roughly cylindrical in shape, forms from the neural keel, and is not yet hollowed out into the neural tube[ZFIN]. http://purl.obolibrary.org/obo/UBERON_0005080 metanephric ureteric bud http://purl.obolibrary.org/obo/UBERON_0000084 ureteric bud The portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros[GO]. http://purl.obolibrary.org/obo/UBERON_0005081 ureter ureteric bud http://purl.obolibrary.org/obo/UBERON_0000084 ureteric bud The portion of the ureteric bud that contributes to the morphogenesis of the ureter. The ureter ureteric bud is the initial structure that forms the ureter[GO]. http://purl.obolibrary.org/obo/UBERON_0005085 ectodermal placode http://purl.obolibrary.org/obo/UBERON_0001048 primordium An ectodermal placode is a thickening of the ectoderm that is the primordium of many structures derived from the ectoderm[GO] http://purl.obolibrary.org/obo/UBERON_0005090 muscle structure http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms[GO]. http://purl.obolibrary.org/obo/UBERON_0005095 kidney rudiment http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure . http://purl.obolibrary.org/obo/UBERON_0005103 mesonephric epithelium http://purl.obolibrary.org/obo/UBERON_0012275 meso-epithelium An epithelium that is part of a mesonephros [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0005153 epithelial bud http://purl.obolibrary.org/obo/UBERON_0005157 epithelial fold A bud is a protrusion that forms from an epithelial sheet by localized folding. http://purl.obolibrary.org/obo/UBERON_0005156 reproductive structure http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure Any anatomical structure that is part of the reproductive system. http://purl.obolibrary.org/obo/UBERON_0005157 epithelial fold http://purl.obolibrary.org/obo/UBERON_0000483 epithelium An epithelial sheet bent on a linear axis. http://purl.obolibrary.org/obo/UBERON_0005162 multi cell part structure http://purl.obolibrary.org/obo/UBERON_0000477 anatomical cluster A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part. http://purl.obolibrary.org/obo/UBERON_0005171 hepatic duct http://purl.obolibrary.org/obo/UBERON_0002394 bile duct Any portion of the ducts that carry bile from the liver to the common bile duct. This may include both intrahapetic components (parts of left and right hepatic ducts) and extrahapetic components (common hepatic duct, plus hilar portion). http://purl.obolibrary.org/obo/UBERON_0005172 abdomen element http://purl.obolibrary.org/obo/UBERON_0005173 abdominal segment element An organ or element that is in the abdomen. Examples: spleen, intestine, kidney, abdominal mammary gland. http://purl.obolibrary.org/obo/UBERON_0005173 abdominal segment element http://purl.obolibrary.org/obo/UBERON_0005177 trunk region element An organ or element that is part of the adbominal segment of the organism. This region can be further subdivided into the abdominal cavity and the pelvic region. http://purl.obolibrary.org/obo/UBERON_0005174 dorsal region element http://purl.obolibrary.org/obo/UBERON_0000062 organ An organ or element that part of the dorsum of the organism. Examples: spinal cord, vertebrae, muscles of back. http://purl.obolibrary.org/obo/UBERON_0005177 trunk region element http://purl.obolibrary.org/obo/UBERON_0000062 organ An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions. http://purl.obolibrary.org/obo/UBERON_0005178 thoracic cavity element http://purl.obolibrary.org/obo/UBERON_0005181 thoracic segment organ An organ or element that is in the thoracic cavity. Examples: lung, heart, longus colli. http://purl.obolibrary.org/obo/UBERON_0005179 pelvic region element http://purl.obolibrary.org/obo/UBERON_0005173 abdominal segment element An organ or element that is part of the pelvic region. Examples: reproductive organs (in some organisms), urinary bladder, bones of the pelvis. http://purl.obolibrary.org/obo/UBERON_0005181 thoracic segment organ http://purl.obolibrary.org/obo/UBERON_0005177 trunk region element An organ that part of the thoracic segment region. This region can be further subdividied chest and thoracic cavity regions. http://purl.obolibrary.org/obo/UBERON_0005253 head mesenchyme http://purl.obolibrary.org/obo/UBERON_0005291 embryonic tissue Portion of primordial embryonic connective tissue of the developing head, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to head connective tissue, bone and musculature in conjunction with cranial neural crest cells. http://purl.obolibrary.org/obo/UBERON_0005256 trunk mesenchyme http://purl.obolibrary.org/obo/UBERON_0005291 embryonic tissue Mesenchyme that is part of a developing trunk. http://purl.obolibrary.org/obo/UBERON_0005290 myelencephalon http://purl.obolibrary.org/obo/UBERON_0004733 segmental subdivision of hindbrain The posterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the medulla oblongata and a portion of the fourth ventricle; as well as the glossopharyngeal nerve (CN IX), vagus nerve (CN X), accessory nerve (CN XI), hypoglossal nerve (CN XII), and a portion of the vestibulocochlear nerve (CN VIII).[BTO,WP]. http://purl.obolibrary.org/obo/UBERON_0005291 embryonic tissue http://purl.obolibrary.org/obo/UBERON_0002050 embryonic structure A portion of tissue that is part of an embryo. http://purl.obolibrary.org/obo/UBERON_0005388 photoreceptor array http://purl.obolibrary.org/obo/UBERON_0004923 organ component layer An array of photoreceptors and any supporting cells found in an eye. http://purl.obolibrary.org/obo/UBERON_0005389 transparent eye structure http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure A transparent structure that is part of a visual sense organ, the function of which is to direct or focus light onto a photoreceptor array. http://purl.obolibrary.org/obo/UBERON_0005399 male reproductive gland http://purl.obolibrary.org/obo/UBERON_0003937 sex gland A sex gland that is part of a male reproductive system. http://purl.obolibrary.org/obo/UBERON_0005418 hindlimb bud http://purl.obolibrary.org/obo/UBERON_0005420 pelvic appendage bud A limb bud that develops into a hindlimb. http://purl.obolibrary.org/obo/UBERON_0005420 pelvic appendage bud http://purl.obolibrary.org/obo/UBERON_0004357 paired limb/fin bud A limb bud that develops into a hindlimb or pelvic fin. http://purl.obolibrary.org/obo/UBERON_0005425 presumptive neural retina http://purl.obolibrary.org/obo/UBERON_0010312 immature eye Portion of tissue that is the inner layer of the optic cup and will become the neural retina. http://purl.obolibrary.org/obo/UBERON_0005426 lens vesicle http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure Portion of tissue that gives rise to the lens. http://purl.obolibrary.org/obo/UBERON_0005427 corneal primordium http://purl.obolibrary.org/obo/UBERON_0010313 neural crest-derived structure Portion of tissue that is part of the eye and gives rise to the mature, fully layered cornea. http://purl.obolibrary.org/obo/UBERON_0005478 sulcus limitans of neural tube http://purl.obolibrary.org/obo/UBERON_0006846 surface groove A longitudinal groove in the neural tube wall that divides the neural tube into dorsal (alar) and ventral (basal) halves (dorsal receives input from sensory neurons, ventral effects motor functions); stretches from the mesencephalon caudad[TMD]. http://purl.obolibrary.org/obo/UBERON_0005496 neural tube lateral wall http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure Portion of tissue on the side of the lumen of the neural tube. http://purl.obolibrary.org/obo/UBERON_0005498 primitive heart tube http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure Multi-tissue structure that arises from the heart rudiment and will become the heart tube. http://purl.obolibrary.org/obo/UBERON_0005564 gonad primordium http://purl.obolibrary.org/obo/UBERON_0001048 primordium Portion of tissue that gives rise to the immature gonad. http://purl.obolibrary.org/obo/UBERON_0005597 lung primordium http://purl.obolibrary.org/obo/UBERON_0001048 primordium A pair of lateral diverticula just over the liver rudiment representing the primordia of the lungs, formed by the floor of the foregut just anterior to the liver diverticulum. http://purl.obolibrary.org/obo/UBERON_0005721 pronephric mesoderm http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure A mesoderm that has the potential to develop into a pronephros. http://purl.obolibrary.org/obo/UBERON_0005725 olfactory system http://purl.obolibrary.org/obo/UBERON_0005726 chemosensory system A sensory system that is capable of olfacttion (the sensory perception of smell). http://purl.obolibrary.org/obo/UBERON_0005730 pelvic appendage field http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure A limb/fin field that has the potential to develop into a pelvic appendage bud mesenchyme. http://purl.obolibrary.org/obo/UBERON_0005731 fin field http://purl.obolibrary.org/obo/UBERON_0005732 paired limb/fin field A limb/fin field that has_potential_to_developmentally_contribute_to a paired fin bud. http://purl.obolibrary.org/obo/UBERON_0005732 paired limb/fin field http://purl.obolibrary.org/obo/UBERON_0007688 anlage A ring of cells capable of forming a limb or paired fin[Gilbert,modified]. http://purl.obolibrary.org/obo/UBERON_0005733 limb field http://purl.obolibrary.org/obo/UBERON_0005732 paired limb/fin field A ring of cells capable of forming a limb. http://purl.obolibrary.org/obo/UBERON_0005753 caudal part of nephrogenic cord http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure The metanephros develops from the most caudal part of the nephrogenic cord that is itself derived from the intermediate plate mesoderm. http://purl.obolibrary.org/obo/UBERON_0005754 rostral part of nephrogenic cord http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure The initial renal anlage that develops from the most rostral part of the nephrogenic cord is termed the pronephros. http://purl.obolibrary.org/obo/UBERON_0005764 acellular membrane http://purl.obolibrary.org/obo/UBERON_0000476 acellular anatomical structure A acellular anatomical structure that is the bounding layer of a anatomical structure. http://purl.obolibrary.org/obo/UBERON_0005769 basement membrane of epithelium http://purl.obolibrary.org/obo/UBERON_0005764 acellular membrane An acellular membrane that is part of the epithelium, lies adjacent to the epithelial cells, and is the fusion of the the basal lamina and the reticular lamina. http://purl.obolibrary.org/obo/UBERON_0005792 nephric ridge http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure Nephric tubules (nephrons) form embryonically along the nephric ridge. The ridge comprises three regions; anterior, middle and posterior. The functional kidney uses nephrons from only one or two regions of the ridge. A pronephric kidney uses only the nephrons from the anterior region of the ridge. A mesonephric kidney uses only the middle region, a metanephric kidney uses only the posterior region and an opisthonephric kidney uses the middle and posterior regions. http://purl.obolibrary.org/obo/UBERON_0005806 portal system http://purl.obolibrary.org/obo/UBERON_0002049 vasculature In the circulatory system of animals, a portal venous system occurs when a capillary bed drains into another capillary bed through veins, without first going through the heart. Both capillary beds and the blood vessels that connect them are considered part of the portal venous system. They are relatively uncommon as the majority of capillary beds drain into veins which then drain into the heart, not into another capillary bed. Portal venous systems are considered venous because the blood vessels that join the two capillary beds are either veins or venules. Examples of such systems include the hepatic portal system and the hypophyseal portal system. Unqualified, 'portal venous system' often refers to the hepatic portal system. For this reason, 'portal vein' most commonly refers to the hepatic portal vein[WP]. http://purl.obolibrary.org/obo/UBERON_0005856 developing mesenchymal condensation http://purl.obolibrary.org/obo/UBERON_0011585 cell condensation A delimited region of dense mesenchyme within looser mesenchyme. http://purl.obolibrary.org/obo/UBERON_0005863 cartilaginous condensation http://purl.obolibrary.org/obo/UBERON_0005856 developing mesenchymal condensation Cell condensation that is an aggregation of mesenchymal cells that are committed to differentiate into chondroblasts and chondrocytes. http://purl.obolibrary.org/obo/UBERON_0005866 pre-cartilage condensation http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure A delimited region of dense mesenchyme within looser mesenchyme whose cells are committed to become chondroblasts. http://purl.obolibrary.org/obo/UBERON_0005881 autopodial extension http://purl.obolibrary.org/obo/UBERON_0000475 organism subdivision A subdivision of the autopod that corresponds to one or more bones arranged in series branching from the main limb axis. http://purl.obolibrary.org/obo/UBERON_0005906 serous sac http://purl.obolibrary.org/obo/UBERON_0000062 organ Organ with organ cavity, which has as parts a serous membrane and a serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.[FMA] http://purl.obolibrary.org/obo/UBERON_0005911 endo-epithelium http://purl.obolibrary.org/obo/UBERON_0004119 endoderm-derived structure Epithelium that derives from the endoderm. Examples: urothelium, transitional epithelium of ureter, epithelium of prostatic gland.[FMA] http://purl.obolibrary.org/obo/UBERON_0005944 axial skeleton plus cranial skeleton http://purl.obolibrary.org/obo/UBERON_0010912 subdivision of skeleton Subdivision of skeleton which consists of cranial skeleton, set of all vertebrae, set of all ribs and sternum[FMA, modified]. http://purl.obolibrary.org/obo/UBERON_0005983 heart layer http://purl.obolibrary.org/obo/UBERON_0004923 organ component layer The laminar structure of the heart http://purl.obolibrary.org/obo/UBERON_0005985 coronary vessel http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure Any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation http://purl.obolibrary.org/obo/UBERON_0006003 integumentary adnexa http://purl.obolibrary.org/obo/UBERON_0000064 organ part Anatomical structure embedded in or located in the integument that is part of the integumental system. Examples: hair, follicles, skin glands, claws, nails, feathers. http://purl.obolibrary.org/obo/UBERON_0006058 multi-limb segment region http://purl.obolibrary.org/obo/UBERON_0010758 subdivision of organism along appendicular axis A collection of two or more connected limb segments. Examples: arm (comprising stylopod and zeugopod regions). http://purl.obolibrary.org/obo/UBERON_0006215 rhombic lip http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure the posterior section of the developing metencephalon recognized transiently within the vertebrate embryo; the rhombic lip extends posteriorly from the roof of the fourth ventricle to dorsal neuroepithelial cell and can be divided into eight structural units based on rhombomeres 1-8 (r1-r8), recognized at early stages of hindbrain development; producing granule cells and five brainstem nuclei, the rhombic lip plays an important role in developing a complex cerebellar neural system http://purl.obolibrary.org/obo/UBERON_0006217 cloacal membrane http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure The membrane that covers the embryonic cloaca, formed by the union of proctodeal (anal pit) ectoderm and cloacal endoderm, with no intervening mesoderm; the urorectal septum joins the cloacal membrane and divides it into an anal membrane and a urogenital membrane; the point where the urorectal septum intersects the cloacal membrane is the future site of the perineal body; proliferation of mesoderm and ectoderm around the cloacal membrane produces primordial tissues of the external genitalia in both sexes: the genital tubercle, genital folds, and genital swellings. http://purl.obolibrary.org/obo/UBERON_0006235 foregut-midgut junction http://purl.obolibrary.org/obo/UBERON_0007651 anatomical junction An anatomical junctions that overlaps the foregut and midgut. http://purl.obolibrary.org/obo/UBERON_0006238 future brain http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure The embryonic precursor of the brain. http://purl.obolibrary.org/obo/UBERON_0006240 future forebrain http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure A presumptive structure that has the potential to develop into a forebrain. http://purl.obolibrary.org/obo/UBERON_0006242 gall bladder primordium http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure A sac-like cavity ventral to the liver, lying in the sub-mesodermal space and closed by a thin sheet of ectodermal cells, from which the future gall bladder develops. http://purl.obolibrary.org/obo/UBERON_0006267 notochordal plate http://purl.obolibrary.org/obo/UBERON_0010371 ecto-epithelium The notochordal plate is the dorsal part of the notochordal process when the ventral portion breaks down. It is continuous laterally with the endoderm that composes the roof of the primitive foregut and is in contact dorsally with the neural tube. The folding off of the notochordal plate gives rise to the notochord. http://purl.obolibrary.org/obo/UBERON_0006268 notochordal process http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure A midline cellular cord formed from the migration of mesenchymal cells from the primitive knot http://purl.obolibrary.org/obo/UBERON_0006283 future cardiac ventricle http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure Multi-tissue structure that is part of the heart tube and will become the cardiac ventricle. http://purl.obolibrary.org/obo/UBERON_0006314 bodily fluid http://purl.obolibrary.org/obo/UBERON_0000463 organism substance Liquid components of living organisms. includes fluids that are excreted or secreted from the body as well as body water that normally is not. http://purl.obolibrary.org/obo/UBERON_0006553 renal duct http://purl.obolibrary.org/obo/UBERON_0000058 duct A tube in the kidney that collect and transport urine. http://purl.obolibrary.org/obo/UBERON_0006555 excretory tube http://purl.obolibrary.org/obo/UBERON_0000025 tube A tube that is part of a excretory system. http://purl.obolibrary.org/obo/UBERON_0006595 presumptive endoderm http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure Presumptive structure of the blastula that will develop into endoderm. http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure Portion of embryonic tissue determined by fate mapping to become a structure. http://purl.obolibrary.org/obo/UBERON_0006601 presumptive ectoderm http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure Presumptive structure of the blastula that will develop into ectoderm. http://purl.obolibrary.org/obo/UBERON_0006603 presumptive mesoderm http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure Presumptive structure of the blastula that will develop into mesoderm. http://purl.obolibrary.org/obo/UBERON_0006658 interphalangeal joint http://purl.obolibrary.org/obo/UBERON_0011139 synovial limb joint A joint that connects one phalanx to another along a proximodistal axis. http://purl.obolibrary.org/obo/UBERON_0006716 mesopodium region http://purl.obolibrary.org/obo/UBERON_0002529 limb segment The third segment of the limb, including either the wrist segment (carpus) or the ankle segment (tarsus) http://purl.obolibrary.org/obo/UBERON_0006717 autopodial skeleton http://purl.obolibrary.org/obo/UBERON_0010712 limb skeleton subdivision The collection of all skeletal elements in an autopodium region. http://purl.obolibrary.org/obo/UBERON_0006799 glandular epithelium http://purl.obolibrary.org/obo/UBERON_0000483 epithelium An epithelium that is composed primarily of secretory cells. http://purl.obolibrary.org/obo/UBERON_0006846 surface groove http://purl.obolibrary.org/obo/UBERON_0003102 surface structure A furrow or an incomplete tube. http://purl.obolibrary.org/obo/UBERON_0006866 terminal part of digestive tract http://purl.obolibrary.org/obo/UBERON_0004921 subdivision of digestive tract The distalmost portion of the digestive tract, derived from the hindgut, and terminating with the anus. http://purl.obolibrary.org/obo/UBERON_0006871 footplate http://purl.obolibrary.org/obo/UBERON_0010130 autopod plate the distal elements of the developing limb of vertebrates that will give rise to the pedal appendages (e.g. hand, foot, paw) http://purl.obolibrary.org/obo/UBERON_0006876 vasculature of organ http://purl.obolibrary.org/obo/UBERON_0002049 vasculature A vasculature that is part of a organ. http://purl.obolibrary.org/obo/UBERON_0006909 lumen of digestive tract http://purl.obolibrary.org/obo/UBERON_0000464 anatomical space An anatomical space that surrounded_by a digestive tract. http://purl.obolibrary.org/obo/UBERON_0006914 squamous epithelium http://purl.obolibrary.org/obo/UBERON_0000483 epithelium An epithelium characterised by its most superficial layer consisting of squamous epithelial cells. http://purl.obolibrary.org/obo/UBERON_0006924 stomach glandular epithelium http://purl.obolibrary.org/obo/UBERON_0006929 glandular columnar epithelium A glandular epithelium that lines the stomach. The stomach's glandular epithelium is characterized by the presence of gastric glands. http://purl.obolibrary.org/obo/UBERON_0006925 digestive gland http://purl.obolibrary.org/obo/UBERON_0013765 digestive system element A gland, such as the liver or pancreas, that secretes into the alimentary canal substances necessary for digestion. http://purl.obolibrary.org/obo/UBERON_0006929 glandular columnar epithelium http://purl.obolibrary.org/obo/UBERON_0006799 glandular epithelium Simple columnar epithelium that constitutes the secretory part of a gland. Examples: epithelium of stomach, luminal epithelium of lactiferous duct.[FMA] http://purl.obolibrary.org/obo/UBERON_0006931 stomach glandular region mucosa http://purl.obolibrary.org/obo/UBERON_0001199 mucosa of stomach stomach mucosa that is lined with glandular epithelium and part of a stomach glandular region. http://purl.obolibrary.org/obo/UBERON_0006965 vascular cord http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure The vascular cord is the primordial vasculature that will develop into blood vessels by the process of tubulogenesis[GO]. The vascular cord is composed of angioblast or vascular endothelial cells in a solid linear mass called a cord. The cord then undergoes tubulogenesis to form the lumen of the vessels[ZFA]. http://purl.obolibrary.org/obo/UBERON_0006984 anatomical surface http://purl.obolibrary.org/obo/UBERON_0000466 immaterial anatomical entity A two dimensional anatomical structure that is the boundary between an anatomical structure and an anatomical substance, an anatomical space or the organism's environment. Examples include the surface of your skin, the surface of the lining of your gut; the surface of the endothelium of you aorta that is in contact with blood.n http://purl.obolibrary.org/obo/UBERON_0007005 cardiac mesoderm http://purl.obolibrary.org/obo/UBERON_0005291 embryonic tissue The splanchnic mesoderm in the cardiogenic region where the heart develops; it gives rise to endocardial heart tubes that fuse to form the primordial cardiac tube, the heart primordium[web]. Two migratory heart primordia that move ventrally during the course of neurulation, and then fuse[XAO]. http://purl.obolibrary.org/obo/UBERON_0007010 cleaving embryo http://purl.obolibrary.org/obo/UBERON_0000922 embryo Organism at the cleavage stage. http://purl.obolibrary.org/obo/UBERON_0007100 primary circulatory organ http://purl.obolibrary.org/obo/UBERON_0015228 circulatory organ A hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood or analogs[GO,modified]. http://purl.obolibrary.org/obo/UBERON_0007123 pharyngeal pouch 2 http://purl.obolibrary.org/obo/UBERON_0004117 pharyngeal pouch A pharyngeal puch that is between the pharyngeal arches 2 and 3. http://purl.obolibrary.org/obo/UBERON_0007135 neural keel http://purl.obolibrary.org/obo/UBERON_0016879 future central nervous system An intermediate stage (between the neural plate and neural rod) during the early segmentation period in the morphogenesis of the central nervous system primordium; the keel is roughly triangular shaped in cross section. http://purl.obolibrary.org/obo/UBERON_0007196 tracheobronchial tree http://purl.obolibrary.org/obo/UBERON_0004119 endoderm-derived structure The structure from the trachea, bronchi, and bronchioles that forms the airways that supply air to the lungs. The lining of the tracheobronchial tree consists of ciliated columnar epithelial cells. http://purl.obolibrary.org/obo/UBERON_0007213 mesenchyme derived from head neural crest http://purl.obolibrary.org/obo/UBERON_0014387 mesenchyme derived from neural crest Mesenchyme that develops_from a cranial neural crest. http://purl.obolibrary.org/obo/UBERON_0007273 pelvic appendage skeleton http://purl.obolibrary.org/obo/UBERON_0011582 paired limb/fin skeleton The collection of all skeletal elements in a pelvic appendage region. http://purl.obolibrary.org/obo/UBERON_0007277 presumptive hindbrain http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure The rhombencephalon (or hindbrain) is a developmental categorization of portions of the central nervous system in vertebrates. The rhombencephalon can be subdivided in a variable number of transversal swellings called rhombomeres. In the human embryo eight rhombomeres can be distinguished, from caudal to rostral: Rh7-Rh1 and the isthmus (the most rostral rhombomere). A rare disease of the rhombencephalon, 'rhombencephalosynapsis' is characterized by a missing vermis resulting in a fused cerebellum. Patients generally present with cerebellar ataxia. The caudal rhombencephalon has been generally considered as the initiation site for neural tube closure. http://purl.obolibrary.org/obo/UBERON_0007281 presumptive midbrain hindbrain boundary http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure Embryonic structure that gives rise to the midbrain hindbrain boundary. http://purl.obolibrary.org/obo/UBERON_0007282 presumptive segmental plate http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure A presumptive structure that has the potential to develop into a presomitic mesoderm. http://purl.obolibrary.org/obo/UBERON_0007284 presumptive neural plate http://purl.obolibrary.org/obo/UBERON_0016879 future central nervous system A presumptive structure that has the potential to develop into a neural plate. http://purl.obolibrary.org/obo/UBERON_0007285 presumptive paraxial mesoderm http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure A presumptive structure that has the potential to develop into a paraxial mesoderm. http://purl.obolibrary.org/obo/UBERON_0007297 presumptive pronephric mesoderm http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure A presumptive structure that has the potential to develop into a pronephric mesoderm. http://purl.obolibrary.org/obo/UBERON_0007324 pancreatic lobule http://purl.obolibrary.org/obo/UBERON_0004119 endoderm-derived structure A dense accumulation of exocrine glands in the pancreas often surrounding islets of Langerhans. http://purl.obolibrary.org/obo/UBERON_0007376 outer epithelium http://purl.obolibrary.org/obo/UBERON_0010371 ecto-epithelium The epidermis is the entire outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species[GO]. http://purl.obolibrary.org/obo/UBERON_0007377 stratum compactum http://purl.obolibrary.org/obo/UBERON_0013754 integumentary system layer Portion of the dermis characterized by a well-arranged, plywood-like, collagenous network. http://purl.obolibrary.org/obo/UBERON_0007383 enveloping layer of ectoderm http://purl.obolibrary.org/obo/UBERON_0010371 ecto-epithelium Outermost layer of cells surrounding the embryo. http://purl.obolibrary.org/obo/UBERON_0007499 epithelial sac http://purl.obolibrary.org/obo/UBERON_0009856 sac An epithelial tube that is open at one end only. http://purl.obolibrary.org/obo/UBERON_0007500 epithelial tube open at both ends http://purl.obolibrary.org/obo/UBERON_0003914 epithelial tube An epithelial tube open at both ends that allows fluid flow. http://purl.obolibrary.org/obo/UBERON_0007503 epithelial vesicle http://purl.obolibrary.org/obo/UBERON_0000483 epithelium A closed epithelium with a lumen. http://purl.obolibrary.org/obo/UBERON_0007524 dense mesenchyme tissue http://purl.obolibrary.org/obo/UBERON_0003104 mesenchyme Mesenchyme with little extracellular matrix. http://purl.obolibrary.org/obo/UBERON_0007530 migrating mesenchyme population http://purl.obolibrary.org/obo/UBERON_0003104 mesenchyme Mesenchymal cells that are migrating. http://purl.obolibrary.org/obo/UBERON_0007592 ciliated columnar epithelium http://purl.obolibrary.org/obo/UBERON_0007601 ciliated epithelium Simple columnar epithelium in which the luminal side of the cells bears cilia. Examples: epithelium of trachea, epithelium of uterine tube.[FMA] http://purl.obolibrary.org/obo/UBERON_0007601 ciliated epithelium http://purl.obolibrary.org/obo/UBERON_0000483 epithelium Epithelium bearing vibratile cilia on the free surface. http://purl.obolibrary.org/obo/UBERON_0007617 synovial cavity of joint http://purl.obolibrary.org/obo/UBERON_0002553 anatomical cavity An anatomical cavity that surrounded_by a synovial joint. http://purl.obolibrary.org/obo/UBERON_0007625 pigment epithelium of eye http://purl.obolibrary.org/obo/UBERON_0019304 sensory organ epithelium epithelial layer of the retina, ciliary body, or iris composed of cells containing pigment granules. http://purl.obolibrary.org/obo/UBERON_0007645 future meninx http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure A developing mesenchymal capsule that covers the developing brain and spinal cord and is the precursor of the meningeal cluster. In mammals this gives rise to the arachnoid mater, pia mater and dura mater. In cyclostomes and fishes, the future meninx gives rise to a single meningeal layer, the primitive meninx. http://purl.obolibrary.org/obo/UBERON_0007651 anatomical junction http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure An anatomical structure that connects two structures http://purl.obolibrary.org/obo/UBERON_0007687 kidney field http://purl.obolibrary.org/obo/UBERON_0007688 anlage region of the embryo into the area in which the kidney rudiment will develop. http://purl.obolibrary.org/obo/UBERON_0007688 anlage http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure Anlagen are populations of contiguous cells, typically arranged in one plane, that are morphologically indistinct, but that already correspond in extent to a later organ/tissue. http://purl.obolibrary.org/obo/UBERON_0007689 thyroid diverticulum http://purl.obolibrary.org/obo/UBERON_0001048 primordium endodermal bud derived from the endodermal epithelium of the embryonic pharyngeal floor[MP]. The thyroid diverticulum is the embryological structure from which thyroid follicular cells derive. It grows from the floor of the pharnyx[WP]. http://purl.obolibrary.org/obo/UBERON_0007690 early pharyngeal endoderm http://purl.obolibrary.org/obo/UBERON_0005291 embryonic tissue . http://purl.obolibrary.org/obo/UBERON_0007794 serous fluid http://purl.obolibrary.org/obo/UBERON_0006314 bodily fluid Any fluid produced by a serous gland. http://purl.obolibrary.org/obo/UBERON_0007811 craniocervical region http://purl.obolibrary.org/obo/UBERON_0000475 organism subdivision The anteriormost subdivision of the body that includes the head, jaws, pharyngeal region and the neck (if present). In vertebrates this is the subdivision that includes the cervical vertebrae. http://purl.obolibrary.org/obo/UBERON_0007823 appendage girdle region http://purl.obolibrary.org/obo/UBERON_0000475 organism subdivision An organism subdivision that encompasses the region containing the pectoral or pelvic girdle. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). http://purl.obolibrary.org/obo/UBERON_0007832 pelvic girdle skeleton http://purl.obolibrary.org/obo/UBERON_0010719 girdle skeleton Skeletal subdivision consisting of a set of bones linking the axial series to the hindlimb zeugopodium and offering anchoring areas for hindlimb and caudal musculature. http://purl.obolibrary.org/obo/UBERON_0007844 cartilage element http://purl.obolibrary.org/obo/UBERON_0004765 skeletal element Skeletal element that is composed of cartilage tissue and may be permanent or transient. http://purl.obolibrary.org/obo/UBERON_0007845 regular connective tissue http://purl.obolibrary.org/obo/UBERON_0002384 connective tissue Connective tissue, which consists of fibroblasts, the intercellular matrix of which contains a regular network of collagen and elastic fiber bundles. Examples: bone (tissue), cartilage (tissue), dense regular connective tissue. http://purl.obolibrary.org/obo/UBERON_0007846 dense regular connective tissue http://purl.obolibrary.org/obo/UBERON_0011823 dense connective tissue Connective tissue that is dominated by collagen fibres organized into a definitive pattern (e.g., parallel to one another), with comparatively fewer cells (mostly fibroblasts). http://purl.obolibrary.org/obo/UBERON_0008784 lower limb segment http://purl.obolibrary.org/obo/UBERON_0002529 limb segment A limb segment that is part of a hindlimb. http://purl.obolibrary.org/obo/UBERON_0008814 pharyngeal arch system http://purl.obolibrary.org/obo/UBERON_0000477 anatomical cluster A transient embryonic complex that comprises the pharyngeal arches, bulges of tissues of mesoderm and neural crest derivation through which pass nerves and pharyngeal arch arteries. The arches are separated internally by pharyngeal pouches, evaginations of foregut endoderm, and externally by pharyngeal clefts, invaginations of surface ectoderm. The development of the system ends when the stucture it contributes to are forming, which may include (depending on species) the thymus, thyroid, parathyroids, maxilla, mandible, aortic arch, cardiac outflow tract, external and middle ear[GO,modified]. http://purl.obolibrary.org/obo/UBERON_0008816 embryonic head http://purl.obolibrary.org/obo/UBERON_0002050 embryonic structure A head that is part of a embryo. http://purl.obolibrary.org/obo/UBERON_0008835 hepatic diverticulum http://purl.obolibrary.org/obo/UBERON_0009854 digestive tract diverticulum An out-pocket of thickened ventral foregut epithelium adjacent to the developing heart. Constitutes the first morphological sign of the embryonic liver. The anterior portion of the hepatic diverticulum gives rise to the liver and intrahepatic biliary tree, while the posterior portion forms the gall bladder and extrahepatic bile ducts. http://purl.obolibrary.org/obo/UBERON_0008858 pyloric canal http://purl.obolibrary.org/obo/UBERON_0009870 zone of stomach The short narrow part of the stomach extending from the pyloric antrum to the pyloric sphincter http://purl.obolibrary.org/obo/UBERON_0008861 pyloric gastric gland http://purl.obolibrary.org/obo/UBERON_0000414 mucous gland The gastric glands in the pyloric region of the stomach; the pyloric glands secrete mucin, which coats the stomach and protects it, and hormones such as gastrin and enkephalin[MP]. http://purl.obolibrary.org/obo/UBERON_0008897 fin http://purl.obolibrary.org/obo/UBERON_0000026 appendage An external projection of an aquatic animal as a fish used in propelling or guiding the body[BTO]. http://purl.obolibrary.org/obo/UBERON_0009034 stomach region http://purl.obolibrary.org/obo/UBERON_0000064 organ part An organ part that is part of a stomach. http://purl.obolibrary.org/obo/UBERON_0009117 indifferent gonad http://purl.obolibrary.org/obo/UBERON_0002050 embryonic structure A gonad prior to differentiating into a definitive testis or ovary. http://purl.obolibrary.org/obo/UBERON_0009142 entire embryonic mesenchyme http://purl.obolibrary.org/obo/UBERON_0000477 anatomical cluster Sum total of mesenchyme in the embryo. http://purl.obolibrary.org/obo/UBERON_0009201 nephric duct http://purl.obolibrary.org/obo/UBERON_0006555 excretory tube A nephric duct is a tube that drains a primitive kidney[GO]. http://purl.obolibrary.org/obo/UBERON_0009497 epithelium of foregut-midgut junction http://purl.obolibrary.org/obo/UBERON_0005911 endo-epithelium An epithelium that is part of a foregut-midgut junction. http://purl.obolibrary.org/obo/UBERON_0009521 anal membrane endodermal component http://purl.obolibrary.org/obo/UBERON_0005911 endo-epithelium An endoderm that is part of a anal region. http://purl.obolibrary.org/obo/UBERON_0009550 endoderm of foregut-midgut junction http://purl.obolibrary.org/obo/UBERON_0000925 endoderm An endoderm that is part of a foregut-midgut junction. http://purl.obolibrary.org/obo/UBERON_0009551 distal segment of digit http://purl.obolibrary.org/obo/UBERON_0002529 limb segment A segment of a digit containing the distal phalanx, and overlapping the distal interphalangeal joint[CJM]. The digit tip is derived from multiple and distinct embryonic origins, and includes the distal bone with associated marrow cavity and haematopoietic cells, ventral (flexor) and dorsal (extensor) tendons, sweat glands with myoepithelial and luminal secreting cells and associated neurons for innervation, dermis with resident melanocytes and dendritic cells, mesenchyme with resident fibroblasts, skin epidermis with hair follicles, a nail organ composed of six specific parts (the root, nail bed, nail plate, eponychium (cuticle), perionychium and hyponychium). http://purl.obolibrary.org/obo/UBERON_0009564 distal limb integumentary appendage http://purl.obolibrary.org/obo/UBERON_0013703 integumentary projection A nail, hoof or claw. http://purl.obolibrary.org/obo/UBERON_0009616 presumptive midbrain http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure A presumptive structure that has the potential to develop into a midbrain. http://purl.obolibrary.org/obo/UBERON_0009662 hindbrain nucleus http://purl.obolibrary.org/obo/UBERON_0002308 nucleus of brain Nucleus located within the hindbrain. http://purl.obolibrary.org/obo/UBERON_0009749 limb mesenchyme http://purl.obolibrary.org/obo/UBERON_0003104 mesenchyme The primordial embryonic connective tissue of the developing limbs, autopods and digits, consisting of mesenchymal cells supported in interlaminar jelly, that derive mostly from the mesoderm and contribute to limb connective tissue, bone and musculature in conjunction with myotome cells. http://purl.obolibrary.org/obo/UBERON_0009768 distal interphalangeal joint http://purl.obolibrary.org/obo/UBERON_0006658 interphalangeal joint An inter-phalangeal joint that connects a distal phalanx to either a medial or proximal phalanx. http://purl.obolibrary.org/obo/UBERON_0009842 glandular acinus http://purl.obolibrary.org/obo/UBERON_0034922 cell cluster The many-lobed berry cluster of cells that is the terminous of a gland where the secretion is produced is acinar in form. http://purl.obolibrary.org/obo/UBERON_0009845 urogenital sinus mesenchyme http://purl.obolibrary.org/obo/UBERON_0003104 mesenchyme Mesenchyme that surrounds primitive urogenital sinus. http://purl.obolibrary.org/obo/UBERON_0009846 embryonic cloacal epithelium http://purl.obolibrary.org/obo/UBERON_0012481 cloacal epithelium An epithelium that is part of a embryonic cloaca. http://purl.obolibrary.org/obo/UBERON_0009847 prostate field http://purl.obolibrary.org/obo/UBERON_0007688 anlage A specific region of the urogenital sinus epithelium into the area in which the prostate gland will develop. http://purl.obolibrary.org/obo/UBERON_0009854 digestive tract diverticulum http://purl.obolibrary.org/obo/UBERON_0009856 sac Branch or outpocketing of the digestive tract. http://purl.obolibrary.org/obo/UBERON_0009870 zone of stomach http://purl.obolibrary.org/obo/UBERON_0034944 zone of organ A division of the stomach. The stomach can be divided based on mucosal histology (glandular epithelium and gastric glands) and the relative position and type of gastric gland. http://purl.obolibrary.org/obo/UBERON_0009877 metapodium region http://purl.obolibrary.org/obo/UBERON_0002529 limb segment Intermediate segment of the autopod, between the mesopodial region and and acropodial region. Examples: metacarpal region, metatarsal region http://purl.obolibrary.org/obo/UBERON_0009878 mesopodial skeleton http://purl.obolibrary.org/obo/UBERON_0010712 limb skeleton subdivision The collection of all skeletal elements in a mesopodium. Examples: the tarsal skeleton, the carpal skeleton http://purl.obolibrary.org/obo/UBERON_0009891 facial mesenchyme http://purl.obolibrary.org/obo/UBERON_0005253 head mesenchyme Mesenchyme that is part of a developing face. http://purl.obolibrary.org/obo/UBERON_0009955 neurogenic placode http://purl.obolibrary.org/obo/UBERON_0002546 cranial placode Cranial ectodermal placode with potential to develop into a component of the nervous system, such as nerves or ganglia. http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure An anatomical structure that has more than one cell as a part. http://purl.obolibrary.org/obo/UBERON_0010001 cell cluster organ http://purl.obolibrary.org/obo/UBERON_0034922 cell cluster A small cluster of cells of various types which form a discrete structure, largely delimited by a morphological boundary and whose components work together to make the whole structure capable of a specific function. http://purl.obolibrary.org/obo/UBERON_0010039 food storage organ http://purl.obolibrary.org/obo/UBERON_0013765 digestive system element An organ of the digestive tract that is capable of retaining and storing food http://purl.obolibrary.org/obo/UBERON_0010081 future common hepatic duct http://purl.obolibrary.org/obo/UBERON_0034932 epithelium of biliary system An extrahepatic bile duct that has the potential to develop into a common hepatic duct. http://purl.obolibrary.org/obo/UBERON_0010083 future dermis http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure Mesenchyme that has the potential to develop into a dermis. http://purl.obolibrary.org/obo/UBERON_0010092 future metencephalon http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure A developing anatomical structure that has the potential to develop into a metencephalon. http://purl.obolibrary.org/obo/UBERON_0010096 future myelencephalon http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure A developing anatomical structure that has the potential to develop into a myelencephalon. http://purl.obolibrary.org/obo/UBERON_0010130 autopod plate http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure The distal elements of the developing limb of vertebrates that will give rise to the pedal appendages (e.g. manus, pes, paw) http://purl.obolibrary.org/obo/UBERON_0010131 conducting tissue of heart http://purl.obolibrary.org/obo/UBERON_0001133 cardiac muscle tissue Any portion of cardiac muscle tissue that is part of the conducting system of heart or the Purkinje fibers. http://purl.obolibrary.org/obo/UBERON_0010147 male accessory sex gland http://purl.obolibrary.org/obo/UBERON_0005399 male reproductive gland Any gland, other than the gonad, associated with the genital tract, such as the ampulla of the ductus deferens and the bulbourethral, prostate and vesicular glands of the male. http://purl.obolibrary.org/obo/UBERON_0010188 protuberance http://purl.obolibrary.org/obo/UBERON_0003102 surface structure A roughly circular bulge in a surface. http://purl.obolibrary.org/obo/UBERON_0010230 eyeball of camera-type eye http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure The core globe-shaped component of the camera-type eye. http://purl.obolibrary.org/obo/UBERON_0010285 midbrain basal plate http://purl.obolibrary.org/obo/UBERON_0002020 gray matter Portion of tissue that is dorsolateral to the floor plate and part of the midbrain. http://purl.obolibrary.org/obo/UBERON_0010286 midbrain neural tube http://purl.obolibrary.org/obo/UBERON_0005291 embryonic tissue Portion of neural tube that gives rise to the midbrain. http://purl.obolibrary.org/obo/UBERON_0010312 immature eye http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure Developing anatomical structure that develops into the eyeball and associated structures. http://purl.obolibrary.org/obo/UBERON_0010313 neural crest-derived structure http://purl.obolibrary.org/obo/UBERON_0010314 structure with developmental contribution from neural crest An anatomical structure that develops from the neural crest. http://purl.obolibrary.org/obo/UBERON_0010314 structure with developmental contribution from neural crest http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure An anatomical structure that has some part that develops from the neural crest. http://purl.obolibrary.org/obo/UBERON_0010329 paired limb/fin bud mesenchyme http://purl.obolibrary.org/obo/UBERON_0010377 mesenchyme from somatopleure Mesenchyme that is part of a limb/fin bud. http://purl.obolibrary.org/obo/UBERON_0010363 endochondral element http://purl.obolibrary.org/obo/UBERON_0004765 skeletal element A skeletal element that has the potential to participate in endochondral ossification, and may participate in intramembranous ossification. http://purl.obolibrary.org/obo/UBERON_0010371 ecto-epithelium http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure Epithelium composed of cells that develops from the ectoderm[FMA,modified]. http://purl.obolibrary.org/obo/UBERON_0010377 mesenchyme from somatopleure http://purl.obolibrary.org/obo/UBERON_0007524 dense mesenchyme tissue Mesenchyme that develops_from a somatopleure. http://purl.obolibrary.org/obo/UBERON_0010409 ocular surface region http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure The integrated unit (of the eye) that consists of the conjunctiva, the corneal surface, and the ocular mucosal adnexa including the lid margins and the meibomian gland openings, the lacrimal glands and the lacrimal drainage system, all which are critical to maintain ocular surface integrity and provide protection from external antigens and pathogenic microorganisms. http://purl.obolibrary.org/obo/UBERON_0010427 ciliary processes http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure The ciliary processes are formed by the inward folding of the various layers of the choroid, i.e. , the choroid proper and the lamina basalis, and are received between corresponding foldings of the suspensory ligament of the lens. http://purl.obolibrary.org/obo/UBERON_0010498 pseudostratified columnar epithelium http://purl.obolibrary.org/obo/UBERON_0000485 simple columnar epithelium A simple columnar epithelium that looks stratified but is not, because its cells are arranged with their nuclei at different levels. http://purl.obolibrary.org/obo/UBERON_0010499 pseudostratified ciliated columnar epithelium http://purl.obolibrary.org/obo/UBERON_0010498 pseudostratified columnar epithelium Epithelium composed of a single layer of cells, appearing as layered because the column-shaped cells vary in height so the nuclei are at different levels. The basal portions of all the cells are in contact with the basement membrane. It lines the respiratory system and the male reproductive tract. The cilia in the respiratory tract are motile, while the stereocilia in the male reproductive tract are immobile. http://purl.obolibrary.org/obo/UBERON_0010523 microcirculatory vessel http://purl.obolibrary.org/obo/UBERON_0000055 vessel A vessel of the microcirculature, lying between the arterioles and venules; includes capillaries (blood and lymphatic), metarterioles and arteriovenous anastomoses. http://purl.obolibrary.org/obo/UBERON_0010538 paired limb/fin segment http://purl.obolibrary.org/obo/UBERON_0010758 subdivision of organism along appendicular axis An appendage segment that is part of a limb/fin. http://purl.obolibrary.org/obo/UBERON_0010543 acropodial skeleton http://purl.obolibrary.org/obo/UBERON_0010712 limb skeleton subdivision The subdivision of the skeleton that consists of all the skeletal elements at the distalmost end of the autopodium - i.e. the bones of the digits or their cartilaginous precursors[VSAO,modified]. http://purl.obolibrary.org/obo/UBERON_0010546 metapodial skeleton http://purl.obolibrary.org/obo/UBERON_0010712 limb skeleton subdivision Subdivision of skeleton that corresponds to metapodium region, between acropodial skeleton and mesopdoial skeleton. http://purl.obolibrary.org/obo/UBERON_0010702 digit mesenchyme http://purl.obolibrary.org/obo/UBERON_0009749 limb mesenchyme Mesenchyme of the digit region. http://purl.obolibrary.org/obo/UBERON_0010707 appendage girdle complex http://purl.obolibrary.org/obo/UBERON_0015212 lateral structure An organism subdivision that includes both an appendage and its accociated girdle region. Note that this includes both the skeletal elements and associated tissues (integument, muscle, etc). http://purl.obolibrary.org/obo/UBERON_0010709 pelvic complex http://purl.obolibrary.org/obo/UBERON_0010707 appendage girdle complex Appendage girdle complex that when present, encompasses the pelvic appendicular skeleton and the pelvic girdle. http://purl.obolibrary.org/obo/UBERON_0010712 limb skeleton subdivision http://purl.obolibrary.org/obo/UBERON_0010912 subdivision of skeleton Skeletal subdivision that is a segment of the limb skeleton. http://purl.obolibrary.org/obo/UBERON_0010713 paired fin skeleton http://purl.obolibrary.org/obo/UBERON_0012353 fin skeleton The collection of all skeletal elements in a single paired fin. http://purl.obolibrary.org/obo/UBERON_0010719 girdle skeleton http://purl.obolibrary.org/obo/UBERON_0010912 subdivision of skeleton The subdivision of the skeleton of either the pectoral or pelvic girdle. http://purl.obolibrary.org/obo/UBERON_0010740 bone of appendage girdle complex http://purl.obolibrary.org/obo/UBERON_0001474 bone element A bone that is part of an appendage girdle complex (i.e. any bone in a limb, fin or girdle). http://purl.obolibrary.org/obo/UBERON_0010758 subdivision of organism along appendicular axis http://purl.obolibrary.org/obo/UBERON_0000475 organism subdivision A major subdivision of an organism that divides an organism along an axis perpedicular to the main body anterior-posterior axis. In vertebrates, this is typically a fin or limb segment. In insects, this includes segments of appendages such as antennae, as well as segments of the insect leg. http://purl.obolibrary.org/obo/UBERON_0010881 limb cartilage element http://purl.obolibrary.org/obo/UBERON_0015061 limb endochondral element A skeletal element that is part of a limb and composed of cartilage tissue. http://purl.obolibrary.org/obo/UBERON_0010882 limb bone pre-cartilage condensation http://purl.obolibrary.org/obo/UBERON_0015061 limb endochondral element A skeletal element that is part of a limb and composed of pre-cartilage tissue. http://purl.obolibrary.org/obo/UBERON_0010912 subdivision of skeleton http://purl.obolibrary.org/obo/UBERON_0011216 organ system subdivision Anatomical cluster consisting of the skeletal elements (i.e. bone elements, cartilage elements, cartilage condensations) that are part of an individual subdivision of the organism. Excludes joints. http://purl.obolibrary.org/obo/UBERON_0011134 nonsynovial joint http://purl.obolibrary.org/obo/UBERON_0000982 skeletal joint Joint in which the articulating bones or cartilages are connected by ligaments or fibrocartilage without an intervening synovial cavity. Examples: sagittal suture, inferior tibiofibular syndesmosis, costochondral joint, pubic symphysis. http://purl.obolibrary.org/obo/UBERON_0011137 axial skeletal system http://purl.obolibrary.org/obo/UBERON_0000075 subdivision of skeletal system Subdivision of the skeletal system which consists of the axial skeleton plus associated joints. http://purl.obolibrary.org/obo/UBERON_0011138 post-cranial axial skeletal system http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure Subdivision of the skeletal system which consists of the post-cranial axial skeleton plus associated joints. http://purl.obolibrary.org/obo/UBERON_0011139 synovial limb joint http://purl.obolibrary.org/obo/UBERON_0003657 limb joint Any synovial joint that is part of a (free) limb. http://purl.obolibrary.org/obo/UBERON_0011143 upper urinary tract http://purl.obolibrary.org/obo/UBERON_0000477 anatomical cluster Subdivision of urinary system which consists of the kidney and the ureters. http://purl.obolibrary.org/obo/UBERON_0011185 gastrointestinal sphincter http://purl.obolibrary.org/obo/UBERON_0013765 digestive system element A sphincter muscle that is part of the gastrointestinal system http://purl.obolibrary.org/obo/UBERON_0011215 central nervous system cell part cluster http://purl.obolibrary.org/obo/UBERON_0005162 multi cell part structure A multi cell part structure that is part of a central nervous system. http://purl.obolibrary.org/obo/UBERON_0011216 organ system subdivision http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure A subdivision of an anatomical system. http://purl.obolibrary.org/obo/UBERON_0011249 appendicular skeletal system http://purl.obolibrary.org/obo/UBERON_0000075 subdivision of skeletal system Subdivision of the skeletal system which consists of the appendicular skeleton plus associated joints. http://purl.obolibrary.org/obo/UBERON_0011250 autopod bone http://purl.obolibrary.org/obo/UBERON_0015063 autopod endochondral element A bone that is part of a autopod region. Note that this incudes the carpal and tarsal bones. http://purl.obolibrary.org/obo/UBERON_0011582 paired limb/fin skeleton http://purl.obolibrary.org/obo/UBERON_0010912 subdivision of skeleton The collection of all skeletal elements in an individual limb or fin. http://purl.obolibrary.org/obo/UBERON_0011583 stylopodial skeleton http://purl.obolibrary.org/obo/UBERON_0010712 limb skeleton subdivision Proximal element of a free limb skeleton consisting of the femur and humerus in the forelimb stylopodium and hindlimb stylopodium respectively[VSAO, modified]. http://purl.obolibrary.org/obo/UBERON_0011584 zeugopodial skeleton http://purl.obolibrary.org/obo/UBERON_0010712 limb skeleton subdivision Section of the forelimb skeleton located between the stylopodium and the autopodium. http://purl.obolibrary.org/obo/UBERON_0011585 cell condensation http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure Anatomical structure that is an aggregation of similar cells from which cartilages and bones form, and from which chondrogenesis and osteogenesis are initiated during repair and/or regeneration. (Hall and Miyake 1995). http://purl.obolibrary.org/obo/UBERON_0011676 subdivision of organism along main body axis http://purl.obolibrary.org/obo/UBERON_0000475 organism subdivision A major subdivision of an organism that divides an organism along its main body axis (typically anterio-posterior axis). In vertebrates, this is based on the vertebral column. http://purl.obolibrary.org/obo/UBERON_0011695 embryonic cardiovascular system http://purl.obolibrary.org/obo/UBERON_0004535 cardiovascular system A cardiovascular system that is part of a conceptus. http://purl.obolibrary.org/obo/UBERON_0011775 vagus nerve nucleus http://purl.obolibrary.org/obo/UBERON_0009662 hindbrain nucleus A cranial nerve nucleus that is associated with a vagus nerve. http://purl.obolibrary.org/obo/UBERON_0011779 nerve of head region http://purl.obolibrary.org/obo/UBERON_0001021 nerve A nerve that is part of a head. http://purl.obolibrary.org/obo/UBERON_0011814 non-neurogenic ectodermal placode http://purl.obolibrary.org/obo/UBERON_0005085 ectodermal placode Ectodermal placode that does not develop into a component of the nervous system. http://purl.obolibrary.org/obo/UBERON_0011821 irregular connective tissue http://purl.obolibrary.org/obo/UBERON_0002384 connective tissue Connective tissue, which consists of a population of connective tissue cells, the intercellular matrix of which contains an irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, mucoid tissue, connective tissue of peritoneum, connective tissue of fibrous pericardium. http://purl.obolibrary.org/obo/UBERON_0011822 dense irregular connective tissue http://purl.obolibrary.org/obo/UBERON_0011823 dense connective tissue Irregular connective tissue is an irregular connective tissue, the intercellular matrix of which contains a dense irregular network of collagen and elastic fiber bundles. Examples: connective tissue of peritoneum, connective tissue of fibrous pericardium. http://purl.obolibrary.org/obo/UBERON_0011823 dense connective tissue http://purl.obolibrary.org/obo/UBERON_0002384 connective tissue Dense connective tissue is mainly composed of collagen type I. Crowded between the collagen fibers are rows of fibroblasts, fiber-forming cells, that manufacture the fibers. Dense connective tissue forms strong, rope-like structures such as tendons and ligaments. Tendons attach skeletal muscles to bones; ligaments connect bones to bones at joints. Ligaments are more stretchy and contain more elastic fibers than tendons. Dense connective tissue also make up the lower layers of the skin (dermis), where it is arranged in sheets http://purl.obolibrary.org/obo/UBERON_0011825 loose connective tissue http://purl.obolibrary.org/obo/UBERON_0011821 irregular connective tissue Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles. Examples: areolar tissue, neuroglial tissue, mucoid tissue. http://purl.obolibrary.org/obo/UBERON_0011858 acinus of exocrine gland http://purl.obolibrary.org/obo/UBERON_0009842 glandular acinus An acinus that is part of a exocrine gland. http://purl.obolibrary.org/obo/UBERON_0011892 anterior uvea http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure Front (ventral) portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris. http://purl.obolibrary.org/obo/UBERON_0011899 epimysium http://purl.obolibrary.org/obo/UBERON_0011822 dense irregular connective tissue Epimysium is a layer of connective tissue which ensheaths the entire muscle. It is composed of dense irregular connective tissue. It is continuous with fascia and other connective tissue wrappings of muscle including the endomysium, and perimysium. It is also continuous with tendons where it becomes thicker and collagenous. http://purl.obolibrary.org/obo/UBERON_0011953 stomach glandular region http://purl.obolibrary.org/obo/UBERON_0009034 stomach region A region of the stomach that is lined with glandular epithelium. http://purl.obolibrary.org/obo/UBERON_0011997 coelom http://purl.obolibrary.org/obo/UBERON_0000481 multi-tissue structure The aggregate of the coelemic cavity lumen plus the membranes that line the lumen. http://purl.obolibrary.org/obo/UBERON_0012101 perinatal stage http://purl.obolibrary.org/obo/UBERON_0000105 life cycle stage The period spanning the range immediately before and after birth http://purl.obolibrary.org/obo/UBERON_0012140 digitopodium region http://purl.obolibrary.org/obo/UBERON_0012139 segment of autopod A segment of the autopod consisting of both acropodial region and metapodial region, but excluding the mesopodial/basopodial region. http://purl.obolibrary.org/obo/UBERON_0012150 skeleton of digitopodium http://purl.obolibrary.org/obo/UBERON_0010712 limb skeleton subdivision A subdivision of the autopod skeleton consisting of both acropodial skeleon and metapodial skeleton, but excluding the mesopodial/basopodial skeleton. http://purl.obolibrary.org/obo/UBERON_0012274 columnar epithelium http://purl.obolibrary.org/obo/UBERON_0000483 epithelium An epithelium that consists of columnar epithelial cells. Columnar epithelia are epithelial cells whose heights are at least four times their width. Columnar epithelia are divided into simple (or unilayered), and the rarer stratified (or multi-layered).[WP, modified] http://purl.obolibrary.org/obo/UBERON_0012275 meso-epithelium http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure Epithelium that derives from the mesoderm. [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0012292 embryonic cloacal fold http://purl.obolibrary.org/obo/UBERON_0002050 embryonic structure One of the pair of mesenchymal swellings (folds) located on either side of the cloacal membrane during the indifferent stage of embryonic development; cranial to the cloacal membrane the folds unite to form the genital tubercle; caudally the folds are subdivided into urogenital folds anteriorly and anal folds posteriorly http://purl.obolibrary.org/obo/UBERON_0012353 fin skeleton http://purl.obolibrary.org/obo/UBERON_0010912 subdivision of skeleton Skeletal subdivision consisting of all the skeletal elements in a single fin. http://purl.obolibrary.org/obo/UBERON_0012354 acropodium region http://purl.obolibrary.org/obo/UBERON_0012139 segment of autopod The segment of the autopod that is distal to the metapodial region and consists of the digits. http://purl.obolibrary.org/obo/UBERON_0012357 digitopodium bone http://purl.obolibrary.org/obo/UBERON_0011250 autopod bone A bone that is part of a the digitopodium skeleton - i.e. the acropodial skeleton or the metapodial skeleton. http://purl.obolibrary.org/obo/UBERON_0012429 hemopoietic tissue http://purl.obolibrary.org/obo/UBERON_0034769 lymphomyeloid tissue Blood-forming tissue, consisting of reticular fibers and cells. Also known as hemopoietic tissue http://purl.obolibrary.org/obo/UBERON_0012430 tunica fibrosa of eyeball http://purl.obolibrary.org/obo/UBERON_0010314 structure with developmental contribution from neural crest The sclera and cornea form the fibrous tunic of the bulb of the eye; the sclera is opaque, and constitutes the posterior five-sixths of the tunic; the cornea is transparent, and forms the anterior sixth. http://purl.obolibrary.org/obo/UBERON_0012476 skeleton of pelvic complex http://purl.obolibrary.org/obo/UBERON_0010912 subdivision of skeleton The collection of all skeletal elements in a pelvic complex - i.e. the combination of free limb or fin plus pelvic girdle. http://purl.obolibrary.org/obo/UBERON_0012481 cloacal epithelium http://purl.obolibrary.org/obo/UBERON_0012275 meso-epithelium An epithelium that is part of a cloaca. http://purl.obolibrary.org/obo/UBERON_0013232 serous acinus http://purl.obolibrary.org/obo/UBERON_0011858 acinus of exocrine gland The secretory unit of a serous gland. The acinar portion is composed of serous secreting cells. http://purl.obolibrary.org/obo/UBERON_0013241 embryonic urethral groove http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure The precursor of the urethra http://purl.obolibrary.org/obo/UBERON_0013514 space surrounding organism http://purl.obolibrary.org/obo/UBERON_0000464 anatomical space The space that surrounds an organism. http://purl.obolibrary.org/obo/UBERON_0013515 subdivision of oviduct http://purl.obolibrary.org/obo/UBERON_0013522 subdivision of tube A section through the tube or network of tubes that connects the ovaries to the outside of the body. http://purl.obolibrary.org/obo/UBERON_0013686 anatomical conduit space http://purl.obolibrary.org/obo/UBERON_0000464 anatomical space An anatomical space which is the lumen of some anatomical conduit and connects two or more spaces together[FMA,modified]. http://purl.obolibrary.org/obo/UBERON_0013701 main body axis http://purl.obolibrary.org/obo/UBERON_0000475 organism subdivision A principle subdivision of an organism that includes all structures along the primary axis, typically the anterior-posterior axis, from head to tail, including structures of the body proper where present (for example, ribs), but excluding appendages. http://purl.obolibrary.org/obo/UBERON_0013702 body proper http://purl.obolibrary.org/obo/UBERON_0000475 organism subdivision The region of the organism associated with the visceral organs. http://purl.obolibrary.org/obo/UBERON_0013703 integumentary projection http://purl.obolibrary.org/obo/UBERON_0006003 integumentary adnexa Anatomical projection that is part of the integumentl system. http://purl.obolibrary.org/obo/UBERON_0013754 integumentary system layer http://purl.obolibrary.org/obo/UBERON_0004923 organ component layer A organ component layer that is part of a integumental system. http://purl.obolibrary.org/obo/UBERON_0013756 venous blood http://purl.obolibrary.org/obo/UBERON_0000178 blood A blood that is part of a vein. http://purl.obolibrary.org/obo/UBERON_0013765 digestive system element http://purl.obolibrary.org/obo/UBERON_0000062 organ Any of the organs or elements that are part of the digestive system. Examples: tongue, esophagus, spleen, crop, lunge feeding organ, tooth elements. http://purl.obolibrary.org/obo/UBERON_0013768 great vessel of heart http://purl.obolibrary.org/obo/UBERON_0001981 blood vessel Great vessels is a term used to refer collectively to the large vessels that bring blood to and from the heart. http://purl.obolibrary.org/obo/UBERON_0014371 future telencephalon http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure Embryonic structure that gives rise to the telencephalon. http://purl.obolibrary.org/obo/UBERON_0014387 mesenchyme derived from neural crest http://purl.obolibrary.org/obo/UBERON_0010313 neural crest-derived structure Mesenchyme that develops_from the neural crest[Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0014477 thoracic skeleton http://purl.obolibrary.org/obo/UBERON_0010912 subdivision of skeleton Subdivision of skeletal system that consists of all skeletal elements in the thoracic region of the trunk. In most vertebrates this is the rib cage and sternum. http://purl.obolibrary.org/obo/UBERON_0014716 interlobular duct http://purl.obolibrary.org/obo/UBERON_0035050 excretory duct A duct that is located between lobules, within the thin connective tissue septa that separate lobules. All interlobular ducts are excretory. http://purl.obolibrary.org/obo/UBERON_0014719 intralobular duct http://purl.obolibrary.org/obo/UBERON_0000058 duct A duct that is located within a lobule, with no more connective tissue intervening between ducts and secretory units (i.e., acini or tubules) than between adjacent secretory units. Intercalated and striated ducts are intralobular http://purl.obolibrary.org/obo/UBERON_0014892 skeletal muscle organ http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure A muscle organ that consists of skeletal muscle tissue ensheathed in epimysium, that develops from myotome and that is innervated by some somatic motor neuron. Skeletal muscles are typically attached (via a tendon) to a bone but there are exceptions (e.g. intrinsic tongue muscles). http://purl.obolibrary.org/obo/UBERON_0014903 primordial vasculature http://purl.obolibrary.org/obo/UBERON_0001048 primordium A portion of tissue that will develop into vasculature. http://purl.obolibrary.org/obo/UBERON_0015023 phalanx endochondral element http://purl.obolibrary.org/obo/UBERON_0015063 autopod endochondral element A phalanx bone or its cartilage or pre-cartilage precursor. http://purl.obolibrary.org/obo/UBERON_0015061 limb endochondral element http://purl.obolibrary.org/obo/UBERON_0010363 endochondral element A limb bone or its cartilage or pre-cartilage precursor. http://purl.obolibrary.org/obo/UBERON_0015063 autopod endochondral element http://purl.obolibrary.org/obo/UBERON_0015061 limb endochondral element A endochondral element that is part of a autopod region. http://purl.obolibrary.org/obo/UBERON_0015064 autopod cartilage http://purl.obolibrary.org/obo/UBERON_0015063 autopod endochondral element A autopod endochondral element that is composed primarily of a cartilage tissue. http://purl.obolibrary.org/obo/UBERON_0015212 lateral structure http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure Any structure that is placed on one side of the left-right axis of a bilaterian. http://purl.obolibrary.org/obo/UBERON_0015228 circulatory organ http://purl.obolibrary.org/obo/UBERON_0003103 compound organ A hollow, muscular organ, which, by contracting rhythmically, contributes to the circulation of lymph, blood or analogs. Examples: a chambered vertebrate heart; the tubular peristaltic heart of ascidians; the dorsal vessel of an insect; the lymoh heart of a reptile. http://purl.obolibrary.org/obo/UBERON_0015808 eye epithelium http://purl.obolibrary.org/obo/UBERON_0010371 ecto-epithelium A epithelium that is part of a camera-type eye. http://purl.obolibrary.org/obo/UBERON_0015833 foregut epithelium http://purl.obolibrary.org/obo/UBERON_0003929 digestive tract epithelium A epithelium that is part of a foregut. http://purl.obolibrary.org/obo/UBERON_0016566 pit http://purl.obolibrary.org/obo/UBERON_0006984 anatomical surface An roughly circular indentation in a surface. http://purl.obolibrary.org/obo/UBERON_0016879 future central nervous system http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure Primordium that develops into the central nervous system http://purl.obolibrary.org/obo/UBERON_0016880 future nervous system http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure Primordium that develops into the nervous system http://purl.obolibrary.org/obo/UBERON_0016887 entire extraembryonic component http://purl.obolibrary.org/obo/UBERON_0000481 multi-tissue structure The part of the conceptus that may be lost before birth or will be discarded at birth, or when the embryo becomes an independent organism. http://purl.obolibrary.org/obo/UBERON_0016888 transitional anatomical structure http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure An embryonic anatomical entity that will turn into one or more other anatomical entities, perhaps with other anatomical entities, later in development. http://purl.obolibrary.org/obo/UBERON_0017650 developing mesenchymal structure http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure A mesenchyme-derived anatomical entity undergoing a transtion to become another structure. http://purl.obolibrary.org/obo/UBERON_0017672 abdominal viscera http://purl.obolibrary.org/obo/UBERON_0005172 abdomen element A viscus that is part of a abdomen. http://purl.obolibrary.org/obo/UBERON_0018260 layer of muscle tissue http://purl.obolibrary.org/obo/UBERON_0004923 organ component layer Any organ component layer that consists of muscle tissue. http://purl.obolibrary.org/obo/UBERON_0018674 heart vasculature http://purl.obolibrary.org/obo/UBERON_0006876 vasculature of organ An interconnected tubular multi-tissue structure that contains fluid that is actively transported around the heart. http://purl.obolibrary.org/obo/UBERON_0019207 chorioretinal region http://purl.obolibrary.org/obo/UBERON_0010314 structure with developmental contribution from neural crest The part of the eye that consists of both the retina and the optic choroid http://purl.obolibrary.org/obo/UBERON_0022303 nervous system cell part layer http://purl.obolibrary.org/obo/UBERON_0005162 multi cell part structure Single layer of a laminar structure, identified by different density, arrangement or size of cells and processes arranged in flattened layers or lamina[CUMBO]. http://purl.obolibrary.org/obo/UBERON_0034705 developing neuroepithelium http://purl.obolibrary.org/obo/UBERON_0000483 epithelium An embryonic or larval epithelium that is committed to form part of the nervous system. http://purl.obolibrary.org/obo/UBERON_0034706 proliferating neuroepithelium http://purl.obolibrary.org/obo/UBERON_0034705 developing neuroepithelium An epithelium that is undergoing proliferation to provide large numbers of neuronal cells. http://purl.obolibrary.org/obo/UBERON_0034707 differentiating neuroepithelium http://purl.obolibrary.org/obo/UBERON_0034705 developing neuroepithelium A neuroepithelium some of whose cells are undergoing terminal differentiation to become neuronal cells. http://purl.obolibrary.org/obo/UBERON_0034713 cranial neuron projection bundle http://purl.obolibrary.org/obo/UBERON_0000122 neuron projection bundle Any of the cranial nerves, or their central nervous system analogs (the optic tract, the epiphyseal tract). These analogs are not true nerves, and are instead evaginated sensory afferents emanating from the brain http://purl.obolibrary.org/obo/UBERON_0034768 morphological feature http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure A part of an organism or organ that is continuous with its surroundings and distinguished from its surroundings based on morphology. http://purl.obolibrary.org/obo/UBERON_0034873 bodily gas http://purl.obolibrary.org/obo/UBERON_0000463 organism substance Any substance in the body or expelled from the body that is in a gaseous state. http://purl.obolibrary.org/obo/UBERON_0034874 air in respiratory system http://purl.obolibrary.org/obo/UBERON_0034947 gas in respiratory system Any portion of gas located in a part of the respiratory system that is composed primarily of air. http://purl.obolibrary.org/obo/UBERON_0034921 multi organ part structure http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure An multicellular anatomical structure that has subparts of multiple organs as a part. http://purl.obolibrary.org/obo/UBERON_0034922 cell cluster http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure A cluster of cells, largely surrounded by a morphological boundary. http://purl.obolibrary.org/obo/UBERON_0034925 anatomical collection http://purl.obolibrary.org/obo/UBERON_0000465 material anatomical entity A collection of anatomical structures that are alike in terms of their morphology or developmental origin. http://purl.obolibrary.org/obo/UBERON_0034929 external soft tissue zone http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure A region or zone on the surface of an organism that encompasses skin and any adnexa, down through muscles and bounded by underlying skeletal support structures. http://purl.obolibrary.org/obo/UBERON_0034932 epithelium of biliary system http://purl.obolibrary.org/obo/UBERON_0000483 epithelium The epithelial layer covering the biliary system. This includes the epithelium of the gallbladder (when present) as well as the intrahepatic and extrahepatic bile ducts. http://purl.obolibrary.org/obo/UBERON_2007013 preplacodal ectoderm http://purl.obolibrary.org/obo/UBERON_0005497 non-neural ectoderm Non neural ectoderm that surrounds the presumptive neural plate and gives rise to neurogenic placodes. http://purl.obolibrary.org/obo/UBERON_3000961 external integument structure http://purl.obolibrary.org/obo/UBERON_0003102 surface structure Structures of the dermis, epidermis, glands and pigment cells recognizable on the external surfaces of the integument. http://purl.obolibrary.org/obo/UBERON_5002544 digit plus metapodial segment http://purl.obolibrary.org/obo/UBERON_0000475 organism subdivision A subdivision of the autopod consisting of digit plus the region incorporating a single metapodial element. These segments are typically repeated along the pre-axiom to post-axial axis. http://purl.obolibrary.org/obo/UBERON_5102544 individual digit of digitopodial skeleton http://purl.obolibrary.org/obo/UBERON_0010712 limb skeleton subdivision A subdivision of the skeleton of the autopod consisting of the phalanges of a single digit plus the associated metapodial element. http://purl.obolibrary.org/obo/OGMS_0000061 pathological bodily process http://purl.obolibrary.org/obo/OGMS_0000060 bodily process A bodily process that is clinically abnormal. http://purl.obolibrary.org/obo/OAE_0002678 fetal death AE http://purl.obolibrary.org/obo/OAE_0000632 death AE a death AE that has death in utero; failure of the product of conception to show evidence of respiration, heartbeat, or definite movement of a voluntary muscle after expulsion from the uterus, without possibility of resuscitation. http://purl.obolibrary.org/obo/OAE_0004387 Grade 3 duodenal ulcer AE http://purl.obolibrary.org/obo/OAE_0000895 duodenal ulcer AE A duodenal ulcer AE that alters GI function and requiresTPN indicated; elective operative or endoscopic intervention indicated; limiting self care ADL. http://purl.obolibrary.org/obo/OAE_0004388 anal hemorrhage AE http://purl.obolibrary.org/obo/OAE_0004229 anus AE An anus AE that bleed from the anal region. http://purl.obolibrary.org/obo/OAE_0004389 Grade 2 anal hemorrhage AE http://purl.obolibrary.org/obo/OAE_0004388 anal hemorrhage AE An anal hemorrhage AE that has moderate symptoms; medical intervention or minor cauterization indicated. http://purl.obolibrary.org/obo/OAE_0004391 Grade 3 anal hemorrhage AE http://purl.obolibrary.org/obo/OAE_0004388 anal hemorrhage AE An anal hemorrhage AE that has transfusion, radiologic, endoscopic, or elective operative intervention indicated. http://purl.obolibrary.org/obo/OAE_0004392 colonic stenosis AE http://purl.obolibrary.org/obo/OAE_0000455 gastrointestinal disorder AE A gastrointestinal disorder AE that has a narrowing of the lumen of the colon. http://purl.obolibrary.org/obo/OAE_0004393 Grade 2 colonic stenosis AE http://purl.obolibrary.org/obo/OAE_0004392 colonic stenosis AE A colonic stenosis AE that altered GI function. http://purl.obolibrary.org/obo/OAE_0004394 Grade 3 colonic stenosis AE http://purl.obolibrary.org/obo/OAE_0004392 colonic stenosis AE A colonic stenosis AE that alters GI function and requires tube feeding or hospitalization. http://purl.obolibrary.org/obo/OAE_0004395 esophageal perforation AE http://purl.obolibrary.org/obo/OAE_0004228 esophagus AE An esophagus AE that has a rupture in the wall of the esophagus. http://purl.obolibrary.org/obo/OAE_0004396 Grade 2 mucosal inflammation AE http://purl.obolibrary.org/obo/OAE_0001526 mucosal inflammation AE A mucosal inflammation AE that has moderate pain which is not interfering with oral intake but modified diet indicated. http://purl.obolibrary.org/obo/OAE_0004397 Grade 3 mucosal inflammation AE http://purl.obolibrary.org/obo/OAE_0001526 mucosal inflammation AE A mucosal inflammation AE that is interfering with oral intake. http://purl.obolibrary.org/obo/OAE_0004398 oral dysesthesia AE http://purl.obolibrary.org/obo/OAE_0002647 dysesthesia AE A dysesthesia AE that has burning or tingling sensation on the lips, tongue or entire mouth. http://purl.obolibrary.org/obo/OAE_0004399 Grade 3 Oral dysesthesia AE http://purl.obolibrary.org/obo/OAE_0004398 oral dysesthesia AE An oral dysesthesia AE that has disabling pain, requires tube feeding and TPN. http://purl.obolibrary.org/obo/OAE_0004400 Grade 2 Oral dysesthesia AE http://purl.obolibrary.org/obo/OAE_0004398 oral dysesthesia AE An oral dysesthesia AE that has m oderate pain and is interfering with oral intake. http://purl.obolibrary.org/obo/OAE_0004401 Grade 1 Oral dysesthesia AE http://purl.obolibrary.org/obo/OAE_0004398 oral dysesthesia AE An oral dysesthesia AE that has mild discomfort but is not interfering with oral intake. http://purl.obolibrary.org/obo/OAE_0004402 Grade 3 periodontal disease AE http://purl.obolibrary.org/obo/OAE_0001283 periodontal disease AE A periodontal disease AE that has spontaneous bleeding, severe bone loss with or without tooth loss and osteonecrosis of maxilla or mandible. http://purl.obolibrary.org/obo/OAE_0004403 Grade 2 periodontal disease AE http://purl.obolibrary.org/obo/OAE_0001283 periodontal disease AE A periodontal disease AE that has moderate gingival recession or gingivitis, multiple sites of bleeding on probing and moderate bone loss. http://purl.obolibrary.org/obo/OAE_0004404 Grade 1 periodontal disease AE http://purl.obolibrary.org/obo/OAE_0001283 periodontal disease AE A periodontal disease AE that has gingival recession or gingivitis, limited bleeding on probing and mild local bone loss. http://purl.obolibrary.org/obo/OAE_0004405 rectal necrosis AE http://purl.obolibrary.org/obo/OAE_0000197 necrosis AE A necrosis AE that there the ecrotic process occurring in the rectal wall. http://purl.obolibrary.org/obo/OAE_0004406 Grade 3 rectal necrosis AE http://purl.obolibrary.org/obo/OAE_0004405 rectal necrosis AE A rectal necrosis AE that requires tube feeding or TPN indicated; radiologic, endoscopic, or operative intervention indicated. http://purl.obolibrary.org/obo/OAE_0004407 salivary duct inflammation AE http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE An inflammation AE that has inflammation of the salivary duct. http://purl.obolibrary.org/obo/OAE_0004408 Grade 3 salivary duct inflammation AE http://purl.obolibrary.org/obo/OAE_0004407 salivary duct inflammation AE A salivary duct inflammation AE that has acute salivary gland necrosis; severe secretion-induced symptoms (e.g., thick saliva/oral secretions or gagging); tube feeding or TPN indicated; limiting self care ADL; disabling http://purl.obolibrary.org/obo/OAE_0004409 Grade 2 salivary duct inflammation AE http://purl.obolibrary.org/obo/OAE_0004407 salivary duct inflammation AE A salivary duct inflammation AE that has thick, ropy, sticky saliva; markedly altered taste; alteration in diet indicated; secretion-induced symptoms; limiting instrumental ADL http://purl.obolibrary.org/obo/OAE_0004410 Grade 1 salivary duct inflammation AE http://purl.obolibrary.org/obo/OAE_0004407 salivary duct inflammation AE A salivary duct inflammation AE that has slightly thickened saliva; slightly altered taste (e.g., metallic) http://purl.obolibrary.org/obo/OAE_0004411 small intestinal mucositis AE http://purl.obolibrary.org/obo/OAE_0000557 inflammation AE An inflammation AE that has inflammation of the mucous membrane of the small intestine. http://purl.obolibrary.org/obo/OAE_0004412 Grade 3 small intestinal mucositis AE http://purl.obolibrary.org/obo/OAE_0004411 small intestinal mucositis AE A small intestinal mucositis AE that has severe pain and is interfering with oral intake; tube feeding, TPN or hospitalization indicated. http://purl.obolibrary.org/obo/OAE_0004413 Grade 3 small intestine ulcer AE http://purl.obolibrary.org/obo/OAE_0001409 small intestine ulcer AE A small intestine ulcer AE that has altered GI function, requires TPN indicated. Elective operative or endoscopic intervention indicated; limiting self care ADL; disablingoperative intervention http://purl.obolibrary.org/obo/OAE_0004414 Grade 2 small intestine ulcer AE http://purl.obolibrary.org/obo/OAE_0001409 small intestine ulcer AE A small intestine ulcer AE that has altered GI function. http://purl.obolibrary.org/obo/OAE_0004415 tooth development disorder AE http://purl.obolibrary.org/obo/OAE_0001458 tooth disorder AE A tooth disorder AE that has a pathological process of the teeth occurring during tooth development. http://purl.obolibrary.org/obo/OAE_0004416 Grade 3 tooth development disorder AE http://purl.obolibrary.org/obo/OAE_0004415 tooth development disorder AE A tooth development disorder AE that has maldevelopment with impairment not surgically correctable. http://purl.obolibrary.org/obo/OAE_0004417 Grade 2 tooth development disorder AE http://purl.obolibrary.org/obo/OAE_0004415 tooth development disorder AE A tooth development disorder AE that has impairment correctable with oral surgery http://purl.obolibrary.org/obo/OAE_0004418 Grade 1 tooth development disorder AE http://purl.obolibrary.org/obo/OAE_0004415 tooth development disorder AE A tooth development disorder AE that has hypoplasia of tooth or enamel. http://purl.obolibrary.org/obo/OAE_0004419 Grade 3 cecitis AE http://purl.obolibrary.org/obo/OAE_0000773 cecitis AE A digestive system AE that has abdominal pain, fever, change in bowel habits with ileus and peritoneal signs. http://purl.obolibrary.org/obo/UBERON_0003071 eye primordium http://purl.obolibrary.org/obo/UBERON_0010371 ecto-epithelium Portion of tissue that is part of the anterior neural keel and will form the optic vesicle[ZFA]. A paired ectodermal placode that becomes invaginated to form the embryonic lens vesicles. http://purl.obolibrary.org/obo/OAE_0003772 Grade 1 international normalized ratio increased AE http://purl.obolibrary.org/obo/OAE_0002088 international normalized ratio increased AE a international normalized ratio increased AE that is greater than 1 - 1.5 times the upper limit of normal; greater than 1 - 1.5 times above baseline if on anticoagulation http://purl.obolibrary.org/obo/OAE_0002638 pharyngeal hemorrhage AE http://purl.obolibrary.org/obo/OAE_0000427 hemorrhage AE a hemorrhage AE that has bleeding from the pharynx. http://purl.obolibrary.org/obo/GO_0008150 biological_process http://purl.obolibrary.org/obo/BFO_0000015 process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end. http://purl.obolibrary.org/obo/GO_0009987 cellular process http://purl.obolibrary.org/obo/GO_0008150 biological_process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. http://purl.obolibrary.org/obo/GO_0044699 single-organism process http://purl.obolibrary.org/obo/GO_0008150 biological_process A biological process that involves only one organism. http://purl.obolibrary.org/obo/GO_0044763 single-organism cellular process http://purl.obolibrary.org/obo/GO_0044699 single-organism process Any process that is carried out at the cellular level, occurring within a single organism. http://purl.obolibrary.org/obo/GO_0008219 cell death http://purl.obolibrary.org/obo/GO_0016265 death Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as "apoptotic bodies"); and/or (3) its corpse (or its fragments) have been engulfed by an adjacent cell in vivo. http://purl.obolibrary.org/obo/GO_0016265 death http://purl.obolibrary.org/obo/GO_0044699 single-organism process A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism. http://purl.obolibrary.org/obo/GO_0070265 necrotic cell death http://purl.obolibrary.org/obo/GO_0008219 cell death A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues. http://purl.obolibrary.org/obo/OGMS_0000045 disorder http://purl.obolibrary.org/obo/BFO_0000040 material entity A material entity which is clinically abnormal and part of an extended organism. Disorders are the physical basis of disease. http://purl.obolibrary.org/obo/UBERON_0034947 gas in respiratory system http://purl.obolibrary.org/obo/UBERON_0034873 bodily gas Any portion of gas located in a part of the respiratory system. http://purl.obolibrary.org/obo/UBERON_0035553 left cardiac chamber http://purl.obolibrary.org/obo/UBERON_0015212 lateral structure Any chamber of the left side of the heart http://purl.obolibrary.org/obo/UBERON_0035804 future mouth http://purl.obolibrary.org/obo/UBERON_0013522 subdivision of tube The primordial mouth region of the developing head. http://purl.obolibrary.org/obo/OAE_0000601 vomiting AE http://purl.obolibrary.org/obo/OAE_0000554 abnormal digestion AE regurgitation AE http://purl.obolibrary.org/obo/OAE_0002258 hemolysis AE http://purl.obolibrary.org/obo/OAE_0000588 hematopoietic system AE Hemolysis AE is a hematopoietic system AE that is the rupturing of erythrocytes (red blood cells) and the release of their contents (cytoplasm) into surrounding fluid. http://purl.obolibrary.org/obo/OAE_0003230 behavior abnormal quality http://purl.obolibrary.org/obo/PATO_0000186 behavioral quality a behavioral quality where the behavior in an organism is abnormal. http://purl.obolibrary.org/obo/OAE_0000402 abdominal pain AE http://purl.obolibrary.org/obo/OAE_0000374 pain AE http://purl.obolibrary.org/obo/OAE_0000698 vasodilatation AE http://purl.obolibrary.org/obo/OAE_0000493 cardiovascular AE http://purl.obolibrary.org/obo/OAE_0000582 sensory capability AE http://purl.obolibrary.org/obo/OAE_0000580 behavioral and neurological AE http://purl.obolibrary.org/obo/OAE_0000542 ataxia AE http://purl.obolibrary.org/obo/OAE_0000581 movement disorder AE http://purl.obolibrary.org/obo/OAE_0004367 Grade 1 nausea AE http://purl.obolibrary.org/obo/OAE_0000600 nausea AE http://purl.obolibrary.org/obo/OAE_0004368 Grade 2 nausea AE http://purl.obolibrary.org/obo/OAE_0000600 nausea AE http://purl.obolibrary.org/obo/OAE_0004369 Grade 3 nausea AE http://purl.obolibrary.org/obo/OAE_0000600 nausea AE http://purl.obolibrary.org/obo/OAE_0000848 viral cardiomyopathy AE http://purl.obolibrary.org/obo/OAE_0000785 cardiomyopathy AE http://purl.obolibrary.org/obo/OAE_0001047 toxin-induced cardiomyopathy AE http://purl.obolibrary.org/obo/OAE_0000785 cardiomyopathy AE http://purl.obolibrary.org/obo/BFO_0000040 material entity http://purl.obolibrary.org/obo/BFO_0000004 independent continuant http://purl.obolibrary.org/obo/BFO_0000141 immaterial entity http://purl.obolibrary.org/obo/BFO_0000004 independent continuant http://purl.obolibrary.org/obo/OGMS_0000060 bodily process http://purl.obolibrary.org/obo/BFO_0000015 process http://purl.obolibrary.org/obo/BFO_0000019 quality http://purl.obolibrary.org/obo/BFO_0000020 specifically dependent continuant http://purl.obolibrary.org/obo/BFO_0000029 site http://purl.obolibrary.org/obo/BFO_0000141 immaterial entity http://purl.obolibrary.org/obo/UBERON_0005726 chemosensory system http://purl.obolibrary.org/obo/UBERON_0001032 sensory system http://purl.obolibrary.org/obo/UBERON_0005604 extrahepatic part of hepatic duct http://purl.obolibrary.org/obo/UBERON_0002394 bile duct http://purl.obolibrary.org/obo/UBERON_0009615 midbrain hindbrain boundary neural plate http://purl.obolibrary.org/obo/UBERON_0000015 anatomical boundary http://purl.obolibrary.org/obo/UBERON_0035050 excretory duct http://purl.obolibrary.org/obo/UBERON_0000058 duct http://purl.obolibrary.org/obo/UBERON_0009856 sac http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure http://purl.obolibrary.org/obo/UBERON_0018254 skeletal musculature http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure http://purl.obolibrary.org/obo/UBERON_0009911 lobule http://purl.obolibrary.org/obo/UBERON_0000063 organ subunit http://purl.obolibrary.org/obo/UBERON_0013522 subdivision of tube http://purl.obolibrary.org/obo/UBERON_0000064 organ part http://purl.obolibrary.org/obo/UBERON_0034944 zone of organ http://purl.obolibrary.org/obo/UBERON_0000064 organ part http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure http://purl.obolibrary.org/obo/UBERON_0000465 material anatomical entity http://purl.obolibrary.org/obo/UBERON_0000153 anterior region of body http://purl.obolibrary.org/obo/UBERON_0000475 organism subdivision http://purl.obolibrary.org/obo/UBERON_0000154 posterior region of body http://purl.obolibrary.org/obo/UBERON_0000475 organism subdivision http://purl.obolibrary.org/obo/UBERON_0001444 subdivision of head http://purl.obolibrary.org/obo/UBERON_0000475 organism subdivision http://purl.obolibrary.org/obo/UBERON_0009569 subdivision of trunk http://purl.obolibrary.org/obo/UBERON_0000475 organism subdivision http://purl.obolibrary.org/obo/UBERON_0011860 collection of collagen fibrils http://purl.obolibrary.org/obo/UBERON_0000476 acellular anatomical structure http://purl.obolibrary.org/obo/UBERON_0005497 non-neural ectoderm http://purl.obolibrary.org/obo/UBERON_0004121 ectoderm-derived structure http://purl.obolibrary.org/obo/UBERON_0015757 heterogeneous tissue http://purl.obolibrary.org/obo/UBERON_0000479 tissue http://purl.obolibrary.org/obo/UBERON_0012361 internal anal region http://purl.obolibrary.org/obo/UBERON_0000481 multi-tissue structure http://purl.obolibrary.org/obo/UBERON_0012469 external anal region http://purl.obolibrary.org/obo/UBERON_0000481 multi-tissue structure http://purl.obolibrary.org/obo/UBERON_0019304 sensory organ epithelium http://purl.obolibrary.org/obo/UBERON_0000483 epithelium http://purl.obolibrary.org/obo/UBERON_0011272 embryonic skin basal layer http://purl.obolibrary.org/obo/UBERON_0010371 ecto-epithelium http://purl.obolibrary.org/obo/UBERON_0008947 respiratory primordium http://purl.obolibrary.org/obo/UBERON_0001048 primordium http://purl.obolibrary.org/obo/UBERON_0010375 pancreas dorsal primordium http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure http://purl.obolibrary.org/obo/UBERON_0010376 pancreas ventral primordium http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure http://purl.obolibrary.org/obo/UBERON_0005795 embryonic uterus http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure http://purl.obolibrary.org/obo/UBERON_0009196 indifferent external genitalia http://purl.obolibrary.org/obo/UBERON_0004176 external genitalia http://purl.obolibrary.org/obo/UBERON_0009708 dorsal pancreas http://purl.obolibrary.org/obo/UBERON_0005177 trunk region element http://purl.obolibrary.org/obo/UBERON_0009709 ventral pancreas http://purl.obolibrary.org/obo/UBERON_0005177 trunk region element http://purl.obolibrary.org/obo/UBERON_0012139 segment of autopod http://purl.obolibrary.org/obo/UBERON_0002529 limb segment http://purl.obolibrary.org/obo/UBERON_0009722 entire pharyngeal arch endoderm http://purl.obolibrary.org/obo/UBERON_0005291 embryonic tissue http://purl.obolibrary.org/obo/UBERON_0034969 epithelial layer of duct http://purl.obolibrary.org/obo/UBERON_0003914 epithelial tube http://purl.obolibrary.org/obo/UBERON_0009581 midbrain mantle layer http://purl.obolibrary.org/obo/UBERON_0004061 neural tube mantle layer http://purl.obolibrary.org/obo/UBERON_0005239 basal plate metencephalon http://purl.obolibrary.org/obo/UBERON_0004064 neural tube basal plate http://purl.obolibrary.org/obo/UBERON_0009618 trunk paraxial mesoderm http://purl.obolibrary.org/obo/UBERON_0005256 trunk mesenchyme http://purl.obolibrary.org/obo/UBERON_0009881 anterior lateral plate mesoderm http://purl.obolibrary.org/obo/UBERON_0005291 embryonic tissue http://purl.obolibrary.org/obo/UBERON_0011222 intra-ocular muscle http://purl.obolibrary.org/obo/UBERON_0004277 eye muscle http://purl.obolibrary.org/obo/UBERON_0004912 biliary bud http://purl.obolibrary.org/obo/UBERON_0009854 digestive tract diverticulum http://purl.obolibrary.org/obo/UBERON_0008836 liver bud http://purl.obolibrary.org/obo/UBERON_0009854 digestive tract diverticulum http://purl.obolibrary.org/obo/UBERON_0000158 membranous layer http://purl.obolibrary.org/obo/UBERON_0004923 organ component layer http://purl.obolibrary.org/obo/UBERON_0015410 heart plus pericardium http://purl.obolibrary.org/obo/UBERON_0005178 thoracic cavity element http://purl.obolibrary.org/obo/UBERON_0010316 germ layer / neural crest http://purl.obolibrary.org/obo/UBERON_0005291 embryonic tissue http://purl.obolibrary.org/obo/UBERON_0003076 posterior neural tube http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure http://purl.obolibrary.org/obo/UBERON_0003080 anterior neural tube http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure http://purl.obolibrary.org/obo/UBERON_0009145 pharyngeal region of foregut http://purl.obolibrary.org/obo/UBERON_0005423 developing anatomical structure http://purl.obolibrary.org/obo/UBERON_0006241 future spinal cord http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure http://purl.obolibrary.org/obo/UBERON_0006596 presumptive blood http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure http://purl.obolibrary.org/obo/UBERON_0007026 presumptive gut http://purl.obolibrary.org/obo/UBERON_0006598 presumptive structure http://purl.obolibrary.org/obo/UBERON_0022288 surface of eyeball http://purl.obolibrary.org/obo/UBERON_0006984 anatomical surface http://purl.obolibrary.org/obo/UBERON_0009920 optic neural crest http://purl.obolibrary.org/obo/UBERON_0007530 migrating mesenchyme population http://purl.obolibrary.org/obo/UBERON_0010700 phalanx pre-cartilage condensation http://purl.obolibrary.org/obo/UBERON_0015023 phalanx endochondral element http://purl.obolibrary.org/obo/UBERON_0010191 aortic system http://purl.obolibrary.org/obo/UBERON_0011216 organ system subdivision http://purl.obolibrary.org/obo/UBERON_0010701 phalanx cartilage element http://purl.obolibrary.org/obo/UBERON_0015064 autopod cartilage http://purl.obolibrary.org/obo/UBERON_0034769 lymphomyeloid tissue http://purl.obolibrary.org/obo/UBERON_0015757 heterogeneous tissue http://purl.obolibrary.org/obo/OAE_0001789 sleep apnea AE a sleep apnea AE is a sleep disorder AE in which breathing repeatedly stops and starts. Basically, it is a crossproduct of sleep disorder AE and apnea AE. http://purl.obolibrary.org/obo/BFO_0000001 entity http://purl.obolibrary.org/obo/RO_0002087 immediately_preceded_by http://purl.obolibrary.org/obo/BFO_0000062 preceded_by starts_at_end_of X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y) http://purl.obolibrary.org/obo/BFO_0000051 has part http://purl.obolibrary.org/obo/RO_0002507 has material contribution from has_part a core relation that holds between a whole and its part http://purl.obolibrary.org/obo/BFO_0000062 preceded_by http://purl.obolibrary.org/obo/RO_0002086 ends after preceded_by X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X) http://purl.obolibrary.org/obo/BFO_0000050 part of http://purl.obolibrary.org/obo/RO_0002131 overlaps part_of a core relation that holds between a part and its whole http://purl.obolibrary.org/obo/RO_0002224 starts with http://purl.obolibrary.org/obo/RO_0002222 temporally related to started by x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. http://purl.obolibrary.org/obo/RO_0002230 ends with http://purl.obolibrary.org/obo/RO_0002222 temporally related to finished by x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. http://purl.obolibrary.org/obo/OAE_0002081 adverse event occurs in http://purl.obolibrary.org/obo/BFO_0000066 occurs in a 'occurs in' relation that is applied at the adverse event setting and indicates where an adverse event occurs in. http://purl.obolibrary.org/obo/OAE_0002616 adverse event preceded by http://purl.obolibrary.org/obo/BFO_0000062 preceded_by a specific 'preceded by' object property that has a domain of an adverse event. http://purl.obolibrary.org/obo/RO_0002178 supplies http://purl.obolibrary.org/obo/RO_0002170 connected to relation between an artery and the structure is supplies with blood. http://purl.obolibrary.org/obo/uberon/core#anteriorly_connected_to anteriorly connected to http://purl.obolibrary.org/obo/RO_0002170 connected to x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y. http://purl.obolibrary.org/obo/uberon/core#distally_connected_to distally connected to http://purl.obolibrary.org/obo/RO_0002170 connected to x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y. http://purl.obolibrary.org/obo/uberon/core#in_central_side_of in_central_side_of http://purl.obolibrary.org/obo/BFO_0000050 part of X in_central_side Y <=> if Y is subdivided into left and right portions around some median divisor, all parts of X are closer to the median divisor than the outermost lateral sides. http://purl.obolibrary.org/obo/uberon/core#posteriorly_connected_to posteriorly connected to http://purl.obolibrary.org/obo/RO_0002170 connected to x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y. http://purl.obolibrary.org/obo/uberon/core#proximally_connected_to proximally connected to http://purl.obolibrary.org/obo/RO_0002170 connected to x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y. http://purl.obolibrary.org/obo/BFO_0000063 precedes http://purl.obolibrary.org/obo/RO_0002222 temporally related to x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. http://purl.obolibrary.org/obo/RO_0002223 starts http://purl.obolibrary.org/obo/BFO_0000050 part of Relation between occurrents, shares a start boundary with. http://purl.obolibrary.org/obo/OAE_0004423 has diameter in cm http://purl.obolibrary.org/obo/OAE_0004422 has size A 'has size' object property that indicates a material entity of round shape has a diameter of a particular length with the cm (centimeter) unit. http://purl.obolibrary.org/obo/RO_0002131 overlaps http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to x overlaps y if and only if there exists some z such that x has part z and z part of y http://purl.obolibrary.org/obo/BSPO_0000120 in_left_side_of http://purl.obolibrary.org/obo/BSPO_0000126 in_lateral_side_of X in_left_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the left portion. http://purl.obolibrary.org/obo/BSPO_0000121 in_right_side_of http://purl.obolibrary.org/obo/BSPO_0000126 in_lateral_side_of X in_right_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the right portion. http://purl.obolibrary.org/obo/BSPO_0000122 in_posterior_side_of http://purl.obolibrary.org/obo/BFO_0000050 part of X posterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the posterior portion. http://purl.obolibrary.org/obo/BSPO_0000123 in_anterior_side_of http://purl.obolibrary.org/obo/BFO_0000050 part of X anterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the anterior portion. http://purl.obolibrary.org/obo/BSPO_0000124 in_proximal_side_of http://purl.obolibrary.org/obo/BFO_0000050 part of X proximal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the proximal portion. http://purl.obolibrary.org/obo/BSPO_0000125 in_distal_side_of http://purl.obolibrary.org/obo/BFO_0000050 part of X distal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the distal portion. http://purl.obolibrary.org/obo/BSPO_0000126 in_lateral_side_of http://purl.obolibrary.org/obo/BFO_0000050 part of X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure http://purl.obolibrary.org/obo/BSPO_0001106 proximalmost_part_of http://purl.obolibrary.org/obo/BSPO_0000124 in_proximal_side_of X proximalmost_part_of Y <=> X is part_of Y and X is adjacent_to the proximal boundary of Y http://purl.obolibrary.org/obo/BSPO_0001108 distalmost_part_of http://purl.obolibrary.org/obo/BSPO_0000125 in_distal_side_of X distalmost_part_of Y <=> X is part_of Y and X is adjacent_to the distal boundary of Y http://purl.obolibrary.org/obo/RO_0002473 composed primarily of http://purl.obolibrary.org/obo/BFO_0000051 has part x composed_primarily_of y iff: more than half of the mass of x is made from parts of y http://purl.obolibrary.org/obo/RO_0002170 connected to http://purl.obolibrary.org/obo/uberon/core#transitively_connected_to transitively_connected to Binary relationship: x connected_to y if and only if there exists some z such that z connects x and y in a ternary connected_to(x,y,z) relationship. http://purl.obolibrary.org/obo/RO_0002488 existence starts during http://purl.obolibrary.org/obo/RO_0002496 existence starts during or after Relation between continuant c and occurrent s, such that every instance of c comes into existing during some s. http://purl.obolibrary.org/obo/RO_0002489 existence starts with http://purl.obolibrary.org/obo/RO_0002488 existence starts during Relation between continuant and occurrent, such that c comes into existence at the start of p. http://purl.obolibrary.org/obo/RO_0002492 existence ends during http://purl.obolibrary.org/obo/RO_0002497 existence ends during or before Relation between continuant c and occurrent s, such that every instance of c ceases to exist during some s, if it does not die prematurely. http://purl.obolibrary.org/obo/RO_0002493 existence ends with http://purl.obolibrary.org/obo/RO_0002492 existence ends during Relation between continuant and occurrent, such that c ceases to exist at the end of p. http://purl.obolibrary.org/obo/RO_0002551 has skeleton http://purl.obolibrary.org/obo/BFO_0000051 has part A relation between a subdivision of an organism and the single subdivision of skeleton that provides structural support for that subdivision. http://purl.obolibrary.org/obo/RO_0002082 simultaneous_with http://purl.obolibrary.org/obo/RO_0002229 ends Relation between occurrents, shares start and end boundaries. http://purl.obolibrary.org/obo/RO_0002229 ends http://purl.obolibrary.org/obo/BFO_0000050 part of Relation between occurrents, shares an end boundary with. http://purl.obolibrary.org/obo/RO_0002081 before or simultaneous with http://purl.obolibrary.org/obo/RO_0002222 temporally related to <= http://purl.obolibrary.org/obo/RO_0002090 immediately precedes http://purl.obolibrary.org/obo/BFO_0000063 precedes meets http://purl.obolibrary.org/obo/RO_0002091 starts during http://purl.obolibrary.org/obo/RO_0002222 temporally related to io http://purl.obolibrary.org/obo/RO_0002092 happens during http://purl.obolibrary.org/obo/RO_0002093 ends during during http://purl.obolibrary.org/obo/RO_0002093 ends during http://purl.obolibrary.org/obo/RO_0002222 temporally related to overlaps http://purl.obolibrary.org/obo/RO_0002494 transformation of http://purl.obolibrary.org/obo/RO_0002202 develops_from http://purl.obolibrary.org/obo/RO_0002351 has member http://purl.obolibrary.org/obo/BFO_0000051 has part http://purl.obolibrary.org/obo/RO_0002371 attaches_to http://purl.obolibrary.org/obo/RO_0002177 attaches_to_part_of http://purl.obolibrary.org/obo/RO_0002202 develops_from http://purl.obolibrary.org/obo/RO_0002507 has material contribution from http://purl.obolibrary.org/obo/RO_0002086 ends after http://purl.obolibrary.org/obo/RO_0002222 temporally related to http://purl.obolibrary.org/obo/RO_0002380 branching_part_of http://purl.obolibrary.org/obo/BFO_0000050 part of http://purl.obolibrary.org/obo/RO_0002007 bounding layer of http://purl.obolibrary.org/obo/BFO_0000050 part of http://purl.obolibrary.org/obo/RO_0002572 luminal space of http://purl.obolibrary.org/obo/BFO_0000050 part of http://purl.obolibrary.org/obo/RO_0002576 skeleton of http://purl.obolibrary.org/obo/BFO_0000050 part of http://purl.obolibrary.org/obo/RO_0002203 develops_into http://purl.obolibrary.org/obo/RO_0002387 has potential to develop into http://purl.obolibrary.org/obo/uberon/core#extends_fibers_into extends_fibers_into http://purl.obolibrary.org/obo/RO_0002170 connected to http://purl.obolibrary.org/obo/uberon/core#existence_starts_and_ends_during existence starts and ends during http://purl.obolibrary.org/obo/RO_0002492 existence ends during http://purl.obolibrary.org/obo/RO_0002495 immediate transformation of http://purl.obolibrary.org/obo/RO_0002494 transformation of http://purl.obolibrary.org/obo/RO_0002254 has developmental contribution from http://purl.obolibrary.org/obo/RO_0002507 has material contribution from http://purl.obolibrary.org/obo/uberon/core#evolved_from evolved_from http://purl.obolibrary.org/obo/RO_0002158 homologous_to http://purl.obolibrary.org/obo/BFO_0000066 occurs in unfolds_in b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t http://purl.obolibrary.org/obo/OAE_0001735 is evidence of AE1 is_evidence_of AE2 if and only if: given an adverse event instance ae1 that instantiates class AE1 (e.g., electrocardiogram qt prolonged AE) and another adverse event instance ae2 that instantiates class AE2 (e.g., arrhythmia AE), both ae1 and ae2 are adverse events that are clinically observed after a medical intervention (at time t0) on the same patient. The presence of ae1 is supported by priori knowledge of medicine to imply the presence of ae2 with some probability P (P is NOT always 1, thus transitivity does not apply to is_evidence_of relation. AE1 is_evidence_of AE2 and AE2 is_evidence_of AE3 DOES NOT imply AE1 is_evidence_of AE3). The instance ae1 and ae2 are observed or detected at time t1 and t2, respectively. The biological onset time for ae1 or ae2 may occur before t1 or t2. The t1 and t2 can be the same time point or different time points. http://purl.obolibrary.org/obo/OAE_0001788 has participant quality an object property that represents a relation between a process and a quality, in which the process has a participant that has the quality. http://purl.obolibrary.org/obo/OAE_0002615 has participant undergoing A shortcut relation that represents the full path of ‘has participant’ some participant that ‘participates in’ some process. http://purl.obolibrary.org/obo/uberon/core#transitively_anteriorly_connected_to transitively anteriorly connected to . http://purl.obolibrary.org/obo/uberon/core#transitively_distally_connected_to transitively distally connected to . http://purl.obolibrary.org/obo/uberon/core#transitively_proximally_connected_to transitively proximally connected to . http://purl.obolibrary.org/obo/BFO_0000067 contains process [copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t http://purl.obolibrary.org/obo/RO_0002219 surrounded_by x surrounded_by y iff: x is adjacent to y and for every region r adjacent to x, r overlaps y http://purl.obolibrary.org/obo/RO_0002220 adjacent_to x adjacent_to y iff: x and y share a boundary http://purl.obolibrary.org/obo/RO_0002176 connects Binary relationship: z connects x if and only if there exists some y such that z connects x and y in a ternary connected_to(x,y,z) relationship. http://purl.obolibrary.org/obo/BSPO_0000096 anterior_to x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer http://purl.obolibrary.org/obo/BSPO_0000097 distal_to x distal_to y iff x is further along the proximo-distal axis than y, towards the appendage tip. A proximo-distal axis extends from tip of an appendage (distal) to where it joins the body (proximal). http://purl.obolibrary.org/obo/BSPO_0000098 dorsal_to x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly). http://purl.obolibrary.org/obo/BSPO_0000099 posterior_to x posterior_to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail. http://purl.obolibrary.org/obo/BSPO_0000100 proximal_to x proximal_to y iff x is closer to the point of attachment with the body than y. http://purl.obolibrary.org/obo/BSPO_0000102 ventral_to x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly). http://purl.obolibrary.org/obo/BSPO_0000107 deep_to Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines. http://purl.obolibrary.org/obo/BSPO_0000108 superficial_to Near the outer surface of the organism. Thus, skin is superficial to the muscle layer. http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to A mereological relationship or a topological relationship http://purl.obolibrary.org/obo/RO_0002387 has potential to develop into x has the potential to develop into y iff x develops into y or if x is capable of developing into y http://purl.obolibrary.org/obo/uberon/core#conduit_for conduit for x is a conduit for y iff y passes through the lumen of x. http://purl.obolibrary.org/obo/RO_0002385 has potential to developmentally contribute to x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y http://purl.obolibrary.org/obo/RO_0002221 surrounds inverse of surrounded_by http://purl.obolibrary.org/obo/RO_0002256 developmentally_induced_by t1 developmentally_induced_by t2 if there is a process of organ induction (GO:0001759) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor tissue type T to T', where T' develops_from T. http://purl.obolibrary.org/obo/RO_0002258 developmentally preceded by http://purl.obolibrary.org/obo/RO_0002569 has_branching_part http://purl.obolibrary.org/obo/uberon/core#channels_from channels_from http://purl.obolibrary.org/obo/uberon/core#channels_into channels_into http://purl.obolibrary.org/obo/RO_0001015 location_of http://purl.obolibrary.org/obo/RO_0002002 has boundary http://purl.obolibrary.org/obo/OAE_0004422 has size http://purl.obolibrary.org/obo/RO_0001025 located_in http://purl.obolibrary.org/obo/RO_0003000 produces http://purl.obolibrary.org/obo/RO_0003001 produced_by http://purl.obolibrary.org/obo/RO_0002150 continuous_with http://purl.obolibrary.org/obo/RO_0002496 existence starts during or after http://purl.obolibrary.org/obo/RO_0002497 existence ends during or before http://purl.obolibrary.org/obo/RO_0002222 temporally related to http://purl.obolibrary.org/obo/RO_0002177 attaches_to_part_of http://purl.obolibrary.org/obo/RO_0002433 contributes to morphology of http://purl.obolibrary.org/obo/RO_0002507 has material contribution from http://purl.obolibrary.org/obo/uberon/core#channel_for channel for http://purl.obolibrary.org/obo/uberon/core#protects protects http://purl.obolibrary.org/obo/uberon/core#subdivision_of subdivision of http://purl.obolibrary.org/obo/uberon/core#transitively_connected_to transitively_connected to http://purl.obolibrary.org/obo/RO_0002134 innervates http://purl.obolibrary.org/obo/RO_0002005 innervated_by http://purl.obolibrary.org/obo/RO_0002158 homologous_to http://purl.obolibrary.org/obo/RO_0002285 developmentally_replaces http://purl.obolibrary.org/obo/RO_0002297 results in formation of