Term IRI Term label Parent term IRI Parent term label Alternative term Definition http://purl.obolibrary.org/obo/IAO_0000580 looking up a centrally registered identifier http://purl.obolibrary.org/obo/OBI_0000011 planned process looking up a CRID A planned process in which a request to a CRID registry is made to return the information associated with a CRID symbol http://purl.obolibrary.org/obo/IAO_0000005 objective specification http://purl.obolibrary.org/obo/IAO_0000033 directive information entity goal specification a directive information entity that describes an intended process endpoint. When part of a plan specification the concretization is realized in a planned process in which the bearer tries to effect the world so that the process endpoint is achieved. http://purl.obolibrary.org/obo/IAO_0000027 data item http://purl.obolibrary.org/obo/IAO_0000030 information content entity data a data item is an information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements. http://purl.obolibrary.org/obo/IAO_0000035 obsolete_study interpretation http://www.geneontology.org/formats/oboInOwl#ObsoleteClass Obsolete Class conclusion A study interpretation is a textual entity about the implications of a study result. Examples include discussion of whether a hypothesis is false, whether the study failed to address the hypothesis, and whether the study results have led to new hypotheses http://purl.obolibrary.org/obo/IAO_0000132 lot number http://purl.obolibrary.org/obo/IAO_0000028 symbol batch number A lot number is an information content entity which is an identical sequence of character borne by part of manufactured product or its packaging for each instances of a product class in a discrete batch of an item. Lot numbers are usually assigned to each separate production run of an item. Manufacturing as a lot might be due to a variety of reasons, for example, a single process during which many individuals are made from the same portion of source material. Lot numbers can be encoded in a pattern of other information objects, such as bar codes, numerals, or patterns of dots. http://purl.obolibrary.org/obo/IAO_0000184 scatter plot http://purl.obolibrary.org/obo/IAO_0000038 graph scattergraph A scatterplot is a graph which uses Cartesian coordinates to display values for two variables for a set of data. The data is displayed as a collection of points, each having the value of one variable determining the position on the horizontal axis and the value of the other variable determining the position on the vertical axis. http://purl.obolibrary.org/obo/IAO_0000300 textual entity http://purl.obolibrary.org/obo/IAO_0000030 information content entity text A textual entity is a part of a manifestation (FRBR sense), a generically dependent continuant whose concretizations are patterns of glyphs intended to be interpreted as words, formulas, etc. http://purl.obolibrary.org/obo/IAO_0000312 publication about an investigation http://purl.obolibrary.org/obo/IAO_0000311 publication scientific publication A publication that is about an investigation http://purl.obolibrary.org/obo/IAO_0000316 introduction to a publication about an investigation http://purl.obolibrary.org/obo/IAO_0000314 document part background A part of a publication about an investigation that is about the objective specification (why the investigation is being done) http://purl.obolibrary.org/obo/IAO_0000317 methods section http://purl.obolibrary.org/obo/IAO_0000314 document part methods A part of a publication about an investigation that is about the study design of the investigation http://purl.obolibrary.org/obo/IAO_0000318 results section http://purl.obolibrary.org/obo/IAO_0000314 document part results A part of a publication about an investigation that is about a study design execution http://purl.obolibrary.org/obo/IAO_0000319 discussion section of a publication about an investigation http://purl.obolibrary.org/obo/IAO_0000314 document part discussion A part of a publication about an investigation that is about the study interpretation of the investigation http://purl.obolibrary.org/obo/IAO_0000323 author contributions section http://purl.obolibrary.org/obo/IAO_0000314 document part contributions by the authors A part of a publication that is about the specific contributions of each author http://purl.obolibrary.org/obo/IAO_0000324 acknowledgements section http://purl.obolibrary.org/obo/IAO_0000314 document part acknowledgments Part of a publication that is about the contributions of people or institutions other than the authors. http://purl.obolibrary.org/obo/IAO_0000325 footnote http://purl.obolibrary.org/obo/IAO_0000314 document part endnote A part of a document that is about a specific other part of the document. Usually footnotes are spatially segregated from the rest of the document. http://purl.obolibrary.org/obo/IAO_0000326 supplementary material to a document http://purl.obolibrary.org/obo/IAO_0000314 document part supporting information part of a document that is segregated from the rest of the document due to its size http://purl.obolibrary.org/obo/IAO_0000573 line graph http://purl.obolibrary.org/obo/IAO_0000038 graph line chart A line graph is a type of graph created by connecting a series of data points together with a line. http://purl.obolibrary.org/obo/IAO_0000574 assigning a centrally registered identifier http://purl.obolibrary.org/obo/OBI_0000011 planned process assigning a CRID a planned process in which a new CRID is created, associated with an entity, and stored in the CRID registry thereby registering it as being associated with some entity http://purl.obolibrary.org/obo/IAO_0000575 associating information with a centrally registered identifier in its registry http://purl.obolibrary.org/obo/OBI_0000011 planned process associating information with a CRID in the CRID registry A planned process in which a CRID registry associates an information content entity with a CRID symbol http://purl.obolibrary.org/obo/IAO_0000577 centrally registered identifier symbol http://purl.obolibrary.org/obo/IAO_0000028 symbol CRID symbol A symbol that is part of a CRID and that is sufficient to look up a record from the CRID's registry. http://purl.obolibrary.org/obo/IAO_0000578 centrally registered identifier http://purl.obolibrary.org/obo/IAO_0000030 information content entity CRID An information content entity that consists of a CRID symbol and additional information about the CRID registry to which it belongs. http://purl.obolibrary.org/obo/IAO_0000579 centrally registered identifier registry http://purl.obolibrary.org/obo/IAO_0000100 data set CRID registry A CRID registry is a dataset of CRID records, each consisting of a CRID symbol and additional information which was recorded in the dataset through a assigning a centrally registered identifier process. http://purl.obolibrary.org/obo/IAO_0000584 time sampled measurement data set http://purl.obolibrary.org/obo/IAO_0000100 data set experimental time series A data set that is an aggregate of data recording some measurement at a number of time points. The time series data set is an ordered list of pairs of time measurement data and the corresponding measurement data acquired at that time. http://purl.obolibrary.org/obo/OBI_0000070 assay http://purl.obolibrary.org/obo/OBI_0000011 planned process scientific observation A planned process with the objective to produce information about the material entity that is the evaluant, by physically examining it or its proxies. http://purl.obolibrary.org/obo/OBI_0000094 material processing http://purl.obolibrary.org/obo/OBI_0000011 planned process material transformation A planned process which results in physical changes in a specified input material http://purl.obolibrary.org/obo/OBI_0000192 microtiter plate http://purl.obolibrary.org/obo/OBI_0000967 container microplate A microtiter_plate is a flat plate with multiple wells used as small test tubes. http://purl.obolibrary.org/obo/OBI_0000576 scattered molecular aggregate http://purl.obolibrary.org/obo/BFO_0000027 object aggregate Collective A scattered molecular aggregate is a material entity that consists of all the molecules of a specific type that are located in some bounded region and which is part of a more massive material entity that has parts that are other such aggregates http://purl.obolibrary.org/obo/OBI_0000659 specimen collection process http://purl.obolibrary.org/obo/OBI_0000011 planned process specimen collection A planned process with the objective of collecting a specimen. http://purl.obolibrary.org/obo/OBI_0000968 device http://purl.obolibrary.org/obo/OBI_0000047 processed material instrument A material entity that is designed to perform a function in a scientific investigation, but is not a reagent. http://purl.obolibrary.org/obo/OBI_0100060 cultured cell population http://purl.obolibrary.org/obo/OBI_0000047 processed material cell culture sample A processed material comprised of a collection of cultured cells that has been continuously maintained together in culture and shares a common propagation history. http://purl.obolibrary.org/obo/OBI_0500000 study design http://purl.obolibrary.org/obo/IAO_0000104 plan specification experimental design A plan specification comprised of protocols (which may specify how and what kinds of data will be gathered) that are executed as part of an investigation and is realized during a study design execution. http://purl.obolibrary.org/obo/OBI_0500006 parallel group design http://purl.obolibrary.org/obo/OBI_0500000 study design independent measure design A parallel group design or independent measure design is a study design which uses unique experimental unit each experimental group, in other word no two individuals are shared between experimental groups, hence also known as parallel group design. Subjects of a treatment group receive a unique combination of independent variable values making up a treatment http://purl.obolibrary.org/obo/OBI_0600015 group assignment http://purl.obolibrary.org/obo/OBI_0000011 planned process study assignment group assignment is a process which has an organism as specified input and during which a role is assigned http://purl.obolibrary.org/obo/OBI_0600043 genetic transformation http://purl.obolibrary.org/obo/OBI_0000094 material processing genetic modification the introduction. alteration or integration of genetic material into a cell or organism http://purl.obolibrary.org/obo/IAO_0020000 identifier http://purl.obolibrary.org/obo/IAO_0000030 information content entity proper name An identifier is an information content entity that is the outcome of a dubbing process and is used to refer to one instance of entity shared by a group of people to refer to that individual entity. http://purl.obolibrary.org/obo/DIDEO_00000001 drug-drug interaction description http://purl.obolibrary.org/obo/IAO_0000030 information content entity DDI description An information content entity that is about a drug-drug interaction. http://purl.obolibrary.org/obo/DIDEO_00000002 data item about biological process http://purl.obolibrary.org/obo/IAO_0000027 data item mechanistic assertion data item A data item that is about a biological process http://purl.obolibrary.org/obo/DIDEO_00000007 drug-drug interaction management option http://purl.obolibrary.org/obo/IAO_0000104 plan specification management option A evidence-based plan specification that specifies processes to prevent or mitigate a drug-drug interaction http://purl.obolibrary.org/obo/DIDEO_00000008 reported drug-drug interaction http://purl.obolibrary.org/obo/DIDEO_00000020 drug-drug interaction interaction occured A drug-drug interaction that has been the subject of a case report or study. http://purl.obolibrary.org/obo/DIDEO_00000019 material entity participant in drug-drug interaction http://purl.obolibrary.org/obo/BFO_0000040 material entity Drug participant in drug-drug interaction A material entity that is either drug product or an ingredient thereof and that participates in a drug-drug interaction. http://purl.obolibrary.org/obo/DIDEO_00000020 drug-drug interaction http://purl.obolibrary.org/obo/GO_0008150 biological_process DDI A biological process that results in a clinically meaningful change to the response of at least one co-administrated drug. http://purl.obolibrary.org/obo/DIDEO_00000022 mechanism of interaction information http://purl.obolibrary.org/obo/IAO_0000030 information content entity drug interaction mechanism An information content entity that represents a drug interaction as a directional series of molecular processes. http://purl.obolibrary.org/obo/DIDEO_00000025 bioavailability measurement datum http://purl.obolibrary.org/obo/IAO_0000032 scalar measurement datum F A scalar measurement datum that is the specified outcome of a drug bioavailability assay. http://purl.obolibrary.org/obo/DIDEO_00000036 absorbability measurement datum http://purl.obolibrary.org/obo/IAO_0000032 scalar measurement datum AUC A a scalar measurement datum that is the specified outcome of an drug absorbability assay. http://purl.obolibrary.org/obo/DIDEO_00000038 drug maximum concentration measurement datum http://purl.obolibrary.org/obo/IAO_0000032 scalar measurement datum Cmax A scalar measurement datum that is the specified outcome of a drug maximum concentration assay. http://purl.obolibrary.org/obo/DIDEO_00000045 U.S. Food and Drug Administration drug label http://purl.obolibrary.org/obo/DIDEO_00000044 drug package insert FDA drug label A drug package insert for FDA-approved drugs that gives information about the drug, including the approved doses and how it's to be given to treat the medical condition for which it was approved. http://purl.obolibrary.org/obo/DIDEO_00000049 pharmacokinetic area under curve information http://purl.obolibrary.org/obo/IAO_0000030 information content entity AUC information An information content entity that is about a pharmacokinetic area under curve. http://purl.obolibrary.org/obo/DIDEO_00000056 evidence information from clinical study http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_Clinical_Trial An evidence information content entity that is about a clinical drug trial. http://purl.obolibrary.org/obo/DIDEO_00000057 evidence information from drug metabolism identification experiment http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Met_Enz_ID An evidence information content entity that is about an in vitro assay that has a part of a drug or a drug metabolite, which participate in a metabolic process, as a specified input. http://purl.obolibrary.org/obo/DIDEO_00000058 evidence information from drug metabolism inhibition experiment http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Met_Enz_Inhibit An evidence information content entity that is about an in vitro assay and that has parts of a drug or drug metabolites, which participate in a negative regulation of a metabolic process, as it's specified input. http://purl.obolibrary.org/obo/DIDEO_00000059 evidence information from transport protein identification experiment http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Trans_Prot_ID An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of drug components being imported across plasma membranes. http://purl.obolibrary.org/obo/DIDEO_00000060 evidence information from transport protein inhibition experiment http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Trans_Prot_Inhibit An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of the inhibition of drug component transporter. http://purl.obolibrary.org/obo/DIDEO_00000061 evidence information from observation-based adverse drug event report http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_Case_Report_ADE An evidence information content entity that is about an assay that was triggered by an adverse drug event. http://purl.obolibrary.org/obo/DIDEO_00000062 evidence information from observational study http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_Observational An evidence information content entity that is about an assay that realizes an observation design. http://purl.obolibrary.org/obo/DIDEO_00000063 evidence information from CYP450 drug metabolism identification experiment http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Met_Enz_ID_Cyp450 An evidence information content entity that is about an in vitro assay that has a part of a drug or a drug metabolite, which participate in a metabolic process that has CYP 450 as a participant, as a specified input. http://purl.obolibrary.org/obo/DIDEO_00000064 evidence information from CYP450 recombinant drug metabolism identification experiment http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Enz_ID_Cyp450_Hum_Recom An evidence information content entity that is about an in vitro assay that has a part of a drug or a drug metabolite, which participate in a metabolic process that has CYP 450 as a participant, as a specified input, and that has a cell line as a specified input. http://purl.obolibrary.org/obo/DIDEO_00000065 evidence information from CYP450 recombinant drug metabolism identification experiment using chemical inhibitors http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Met_Enz_ID_Cyp450_Hum_Recom_Chem An evidence information content entity that is about an in vitro assay that has a part of a drug or a drug metabolite, which participate in a metabolic process that has CYP 450 as a participant, as a specified input, and that has human tissue specimen as a specified input, and that has chemical inhibitors as a specified input. http://purl.obolibrary.org/obo/DIDEO_00000066 evidence information from CYP450 recombinant drug metabolism identification experiment using antibody inhibitors http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Met_Enz_ID_Cyp450_Hum_Recom_Antibody An evidence information content entity that is about an in vitro assay that has a part of a drug or a drug metabolite, which participate in a metabolic process that has CYP 450 as a participant, as a specified input, and that has human tissue specimen as a specified input, and that has antibody inhibitors as a specified input. http://purl.obolibrary.org/obo/DIDEO_00000067 evidence information from CYP450 human microsome drug metabolism identification experiment http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Met_Enz_ID_Cyp450_Hum_Microsome An evidence information content entity that is about an in vitro assay that has a part of a drug or a drug metabolite, which participate in a metabolic process that has CYP 450 as a participant, as a specified input, and that has human tissue specimen as a specified input. http://purl.obolibrary.org/obo/DIDEO_00000068 evidence information from CYP450 human microsome drug metabolism identification experiment using chemical inhibitors http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Met_Enz_ID_Cyp450_Hum_Microsome_Chem An evidence information content entity that is about an in vitro assay that has a part of a drug or a drug metabolite, which participate in a metabolic process that has CYP 450 as a participant, as a specified input, and that has human tissue specimen as a specified input, and that has chemical inhibitors as a specified input. http://purl.obolibrary.org/obo/DIDEO_00000069 evidence information from CYP450 human microsome drug metabolism identification experiment using antibody inhibitors http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Met_Enz_ID_Cyp450_Hum_Microsome_Antibody An evidence information content entity that is about an in vitro assay that has a part of a drug or a drug metabolite, which participate in a metabolic process that has CYP 450 as a participant, as a specified input, and that has human tissue specimen as a specified input, and that has antibody inhibitors as a specified input. http://purl.obolibrary.org/obo/DIDEO_00000070 evidence information from CYP450 metabolic enzyme inhibition experiment http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Met_Enz_Inhibit_Cyp450 An evidence information content entity that is about an in vitro assay and that has parts of a drug or drug metabolites, which participate in a negative regulation of a metabolic process that also involves CYP 450, as it's specified input. http://purl.obolibrary.org/obo/DIDEO_00000071 evidence information from drug-drug interaction clinical trial http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_CT_DDI An evidence information content entity that is about a clinical drug trial that has at least two drugs as its specified input. http://purl.obolibrary.org/obo/DIDEO_00000072 evidence information from non-randomized drug-drug interaction clinical trial http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_PK_DDI_NR An evidence information content entity that is about a clinical drug trial that has at least two drugs as its specified input and does not have group randomization as a part. http://purl.obolibrary.org/obo/DIDEO_00000073 evidence information from parallel groups drug-drug interaction clinical trial' http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_PK_DDI_Par_Grps An evidence information content entity that is about a clinical drug trial that has at least two drugs as its specified input, and that does not have group randomization as a part, and that realizes a clinical study design that has parallel group design as a part. http://purl.obolibrary.org/obo/DIDEO_00000074 evidence information from randomized drug-drug interaction clinical trial http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_PK_DDI_RCT An evidence information content entity that is about a clinical drug trial that has at least two drugs as its specified input and does have group randomization as a part. http://purl.obolibrary.org/obo/DIDEO_00000075 evidence information from pharmacokinetic trial http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_CT_Pharmacokinetic An evidence information content entity that is about a clinical drug trial that focusses on pharmacokinetics. http://purl.obolibrary.org/obo/DIDEO_00000076 evidence information from genotyped pharmacokinetic trial http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_CT_PK_Genotype An evidence information content entity that is about a clinical drug trial that focusses on pharmacokinetics and that has organisms as participants that participated in genotyping. http://purl.obolibrary.org/obo/DIDEO_00000077 evidence information from observation-based report http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_Case_Report An evidence information content entity that is about an assay that was triggered by an occurrent. http://purl.obolibrary.org/obo/DIDEO_00000078 evidence information from observational pharmacokinetic study http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_PK_Observational An evidence information content entity that is about an assay that realizes an observation design and has a drug product as a specified input, and that focuses on pharmacokinetics in an organism. http://purl.obolibrary.org/obo/DIDEO_00000079 evidence information from observational drug-drug interaction study http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_PK_DDI_Observational An evidence information content entity that is about an assay that realizes an observation design and has at least two drug products as a specified input, and that focuses on pharmacokinetics in an organism. http://purl.obolibrary.org/obo/DIDEO_00000080 evidence information from CYP450 recombinant drug metabolism inhibition experiment http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Met_Enz_Inhibit_Cyp450_Hum_Recom An evidence information content entity that is about an in vitro assay and that has parts of a drug or drug metabolites, which participate in a negative regulation of a metabolic process that also involves CYP 450, as it's specified input, and that has cell lines as a specified input. http://purl.obolibrary.org/obo/DIDEO_00000081 evidence information from CYP450 human microsome drug metabolism inhibition experiment http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Met_Enz_Inhibit_Cyp450_Hum_Microsome An evidence information content entity that is about an in vitro assay and that has parts of a drug or drug metabolites, which participate in a negative regulation of a metabolic process that also involves CYP 450, as it's specified input, and that has human tissue specimens as a specified input. http://purl.obolibrary.org/obo/DIDEO_00000083 evidence information from a publicly reported observation-based adverse drug event report http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_Case_Report_ADE_Public_Reported An evidence information content entity that is about an assay that was triggered by an adverse drug event, and that is part on a publicly accessible database for adverse event reporting. http://purl.obolibrary.org/obo/DIDEO_00000084 evidence information from an observation-based case-report of a drug interaction http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_Case_Report_DI An evidence information content entity that is about an assay that was triggered by an adverse drug event following the administration of at least two drugs. http://purl.obolibrary.org/obo/DIDEO_00000088 evidence information from an evaluated observation-based case-report of a drug interaction http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_Case_Report_DI_Evaluated An evidence information content entity that is about an assay that was triggered by an adverse drug event following the administration of at least two drugs, and that is the specified outcome of a adverse drug reaction causality evaluation. http://purl.obolibrary.org/obo/DIDEO_00000089 clearance measurement datum http://purl.obolibrary.org/obo/IAO_0000109 measurement datum Cl A measurement datum that is the specified output of measuring the volume of plasma that is completely cleared off of a substance per unit time. http://purl.obolibrary.org/obo/DIDEO_00000093 area under the curve ratio http://purl.obolibrary.org/obo/DIDEO_00000095 pharmacokinetic parameter ratio AUC ratio A pharmacokinetic parameter ratio that describes the relation between the pharmacokinetic area under the curve (AUC) for a given active ingredient or metabolite in an organism with and without the inhibiting drug present in the organism. http://purl.obolibrary.org/obo/DIDEO_00000094 renal clearance ratio http://purl.obolibrary.org/obo/DIDEO_00000095 pharmacokinetic parameter ratio CL_R ratio A pharmacokinetic parameter ratio that describes the relation between the measurement of the volume of blood, serum, or plasma from which an active ingredient or a metabolite is completely removed by the kidney in a given amount of time in an organism with and without the inhibiting drug present in the organism. http://purl.obolibrary.org/obo/DIDEO_00000099 drug maximum concentration ratio http://purl.obolibrary.org/obo/DIDEO_00000095 pharmacokinetic parameter ratio Cmax ratio A pharmacokinetic parameter ratio that describes the relation between the drug maximum concentration measurements for a given active ingredient or metabolite in an organism with and without the inhibiting drug present in the organism. http://purl.obolibrary.org/obo/DIDEO_00000100 half-life ratio http://purl.obolibrary.org/obo/DIDEO_00000095 pharmacokinetic parameter ratio t1/2 ratio A pharmacokinetic parameter ratio that describes the relation between the time it takes for half of a given active ingredient or metabolite to be removed from the system of an organism with and without the inhibiting drug present in the organism. http://purl.obolibrary.org/obo/DIDEO_00000101 hepatic clearance ratio http://purl.obolibrary.org/obo/DIDEO_00000095 pharmacokinetic parameter ratio CL_H ratio A pharmacokinetic parameter ratio that describes the relation between the measurement of the volume of blood, serum, or plasma from which an active ingredient or a metabolite is completely removed by the liver in a given amount of time in an organism with and without the inhibiting drug present in the organism. http://purl.obolibrary.org/obo/DIDEO_00000102 bioavailability ratio http://purl.obolibrary.org/obo/DIDEO_00000095 pharmacokinetic parameter ratio F ratio A pharmacokinetic parameter ratio that describes the relation between the measurement of the fraction of the administered dose of an unaltered drug that reaches systemic circulation in the abscene of another drug, and the the measurement of the fraction of the administered dose of an unaltered drug that reaches systemic circulation when coadministered with another drug. http://purl.obolibrary.org/obo/DIDEO_00000103 evidence information from phenotyped pharmacokinetic trial http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_CT_PK_Phenotype An evidence information content entity that is about a clinical drug trial that focusses on pharmacokinetics and that has organisms as participants that participated in phenotyping. http://purl.obolibrary.org/obo/DIDEO_00000104 evidence information from p-glycoprotein transport protein identification experiment http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Trans_Prot_ID_P_Glycoprotein An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of drug components being imported across plasma membranes by involvement of P-Glycoprotein. http://purl.obolibrary.org/obo/DIDEO_00000105 evidence information from p-glycoprotein transport protein identification experiment using Caco 2 cell lines http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Trans_Prot_ID_P_Glycoprotein_Caco_2 An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of drug components being imported across plasma membranes by involvement of P-Glycoprotein using bidirectional flux in Caco-2 cells. http://purl.obolibrary.org/obo/DIDEO_00000106 evidence information from p-glycoprotein transport protein identification experiment using overexpressed cell lines http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Trans_Prot_ID_P_Glycoprotein_Overexpressed_Cells An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of drug components being imported across plasma membranes by involvement of P-Glycoprotein using overexpressed cells. http://purl.obolibrary.org/obo/DIDEO_00000107 evidence information from OATP1B1 transport protein identification experiment http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Trans_Prot_ID_OATP1B1 An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of drug components being imported across plasma membranes by involvement of OATP1B1. http://purl.obolibrary.org/obo/DIDEO_00000108 evidence information from OATP1B3 transport protein identification experiment http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Trans_Prot_ID_OATP1B3 An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of drug components being imported across plasma membranes by involvement of OATP1B3. http://purl.obolibrary.org/obo/DIDEO_00000109 evidence information from OATP1B1 transport protein identification experiment using overexpressed cell lines http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Trans_Prot_ID_OATP1B1_Overexpressed_Cells An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of drug components being imported across plasma membranes by involvement of OATP1B1 using overexpressed cells. http://purl.obolibrary.org/obo/DIDEO_00000110 evidence information from OATP1B3 transport protein identification experiment using overexpressed cell lines http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Trans_Prot_ID_OATP1B3_Overexpressed_Cells An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of drug components being imported across plasma membranes by involvement of OATP1B3 using overexpressed cells. http://purl.obolibrary.org/obo/DIDEO_00000111 evidence information from p-glycoprotein inhibition experiment http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Trans_Prot_Inhibit_P_Glycoprotein An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of the inhibition of P-Glycoprotein. http://purl.obolibrary.org/obo/DIDEO_00000112 evidence information from p-glycoprotein inhibition experiment using Caco 2 cell lines http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Trans_Prot_Inhibit_P_Glycoprotein_Caco_2 An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of the inhibition of P-Glycoprotein, and that has Caco 2 cell lines as a specified input. http://purl.obolibrary.org/obo/DIDEO_00000113 evidence information from p-glycoprotein inhibition experiment using overexpressed cell lines http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Trans_Prot_Inhibit_P_Glycoprotein_Overexpressed_Cells An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of the inhibition of P-Glycoprotein, and that has overexpressed cell lines as a specified input. http://purl.obolibrary.org/obo/DIDEO_00000114 evidence information from OATP1B1 inhibition experiment http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Trans_Prot_Inhibit_OATP1B1 An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of the inhibition of OATP1B1. http://purl.obolibrary.org/obo/DIDEO_00000115 evidence information from OATP1B1 inhibition experiment using overexpressed cell lines http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Trans_Prot_Inhibit_OATP1B1_Overexpressed_Cells An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of the inhibition of OATP1B1, and that has overexpressed cell lines as a specified input. http://purl.obolibrary.org/obo/DIDEO_00000116 evidence information from OATP1B3 inhibition experiment using overexpressed cell lines http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Trans_Prot_Inhibit_OATP1B3_Overexpressed_Cells An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of the inhibition of OATP1B3, and that has overexpressed cell lines as a specified input. http://purl.obolibrary.org/obo/DIDEO_00000117 evidence information from OATP1B3 inhibition experiment http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity EV_EX_Trans_Prot_Inhibit_OATP1B3 An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of the inhibition of OATP1B3. http://purl.obolibrary.org/obo/DIDEO_00000119 time to maximum drug concentration ratio http://purl.obolibrary.org/obo/DIDEO_00000095 pharmacokinetic parameter ratio Tmax ratio A pharmacokinetic parameter ratio that describes the time from dose administration until a drug reaches its maximum concentration for a given active ingredient or metabolite in an organism with and without the inhibiting drug present in the organism. It is expressed as a ratio of the Tmax with the inhibitor present as the numerator and absent as the denominator. http://purl.obolibrary.org/obo/DIDEO_00000122 inhibitory constant http://purl.obolibrary.org/obo/IAO_0000109 measurement datum ki A measurement data that gives the concentration of an inhibiting agent to reach half of the maximum inhibition of a meabolic or transport process. http://purl.obolibrary.org/obo/INO_0000114 overexpression http://purl.obolibrary.org/obo/INO_0000102 gene expression overexpression a gene expression that has increased volume. http://purl.obolibrary.org/obo/DIDEO_00000159 HBG BC2 cell http://purl.obolibrary.org/obo/CLO_0000001 cell line cell BC2 cell an immortal human liver-derived cell line cell that is part of the HBG BC2 cell line http://purl.obolibrary.org/obo/DIDEO_00000196 lamotrigine glucuronosylation http://purl.obolibrary.org/obo/MOP_0000156 glucuronosylation lamotrigine glucuronidation a glucuronosylation that has lamotrigine as input and has lamotrigine glucoronide as output http://purl.obolibrary.org/obo/ERO_0001205 RNA oligonucleotide http://purl.obolibrary.org/obo/ERO_0001202 RNA reagent RNA oligo An RNA reagent consisting of a short, linear RNA polymer, typically with 100 or fewer bases. http://purl.obolibrary.org/obo/ERO_0001206 RNA interference oligonucleotide http://purl.obolibrary.org/obo/ERO_0001205 RNA oligonucleotide RNAi oligonucleotide An RNA interference reagent used to silence expression of a target gene in cells, through the RNA interference pathway. http://purl.obolibrary.org/obo/ERO_0001209 siRNA oligonucleotide http://purl.obolibrary.org/obo/ERO_0001206 RNA interference oligonucleotide siRNA oligo An RNA interference oligonucleotide capable of silencing expression of a target gene through the RNAi pathway. siRNAs are synthesized as single-stranded molecules, typically 19-25 nucleotides in length, and paired with complementary sequences to form duplexes that serve as substrates for cellular RNAi processing machinery. http://purl.obolibrary.org/obo/IAO_0000606 abbreviations section http://purl.obolibrary.org/obo/IAO_0000314 document part list of abbreviations used A part of a document where abbreviations and their long-forms used within the document are listed. http://purl.obolibrary.org/obo/IAO_0000607 author information section http://purl.obolibrary.org/obo/IAO_0000314 document part authors’ information A part of a document about the authors that provides biographical information and may discuss how the authors' professional experiences are relevant to the work described in the document. http://purl.obolibrary.org/obo/IAO_0000609 author summary section http://purl.obolibrary.org/obo/IAO_0000314 document part synopsis A part of a document, distinct from the abstract, that describes the significance and broader context of the document content. The author summary is often written in a non-technical manner and is aimed at both scientists and non-scientist readers. http://purl.obolibrary.org/obo/IAO_0000611 availability section http://purl.obolibrary.org/obo/IAO_0000314 document part availability A part of a document about a resource described in the document, e.g. software, that describes where and/or how that resource can be obtained. http://purl.obolibrary.org/obo/IAO_0000613 case report section http://purl.obolibrary.org/obo/IAO_0000314 document part case report A part of a document about the medical history of a specific patient as it relates to the topic of the document. http://purl.obolibrary.org/obo/IAO_0000615 conclusion section http://purl.obolibrary.org/obo/IAO_0000314 document part summary A part of a document used to summarize the findings discussed in the document. The conclusion section is typically found near the end of a document. http://purl.obolibrary.org/obo/IAO_0000616 conflict of interest section http://purl.obolibrary.org/obo/IAO_0000314 document part disclosure of potential conflicts of interest A part of a document used to declare any competing interests regarding the authors and/or funding organization for the work described in the document. http://purl.obolibrary.org/obo/IAO_0000618 consent section http://purl.obolibrary.org/obo/IAO_0000314 document part consent A part of a document about the consent process that was used to enroll patients in a study. http://purl.obolibrary.org/obo/IAO_0000620 ethical approval section http://purl.obolibrary.org/obo/IAO_0000314 document part ethical approval A part of a document about the governance body responsible for approving the work discussed in a document on an ethical basis. http://purl.obolibrary.org/obo/IAO_0000622 figures section http://purl.obolibrary.org/obo/IAO_0000314 document part figures A part of a document that contains one or more figures. http://purl.obolibrary.org/obo/IAO_0000623 funding source declaration section http://purl.obolibrary.org/obo/IAO_0000314 document part sources of funding A part of a document used to detail information regarding the source of funding used in support of the generation of the document content. http://purl.obolibrary.org/obo/IAO_0000625 future directions section http://purl.obolibrary.org/obo/IAO_0000314 document part future work A part of a document detailing extensions of the described work that may be implemented at some future point in time. http://purl.obolibrary.org/obo/IAO_0000627 genome announcement section http://purl.obolibrary.org/obo/IAO_0000314 document part genome announcement A document part announcing the publication of a novel draft genome sequence. http://purl.obolibrary.org/obo/IAO_0000630 keywords section http://purl.obolibrary.org/obo/IAO_0000314 document part keywords A part of a document where keywords selected by the author to categorize the major theme(s) of a document are listed. http://purl.obolibrary.org/obo/IAO_0000631 study limitations section http://purl.obolibrary.org/obo/IAO_0000314 document part study limitations A part of a document about biases or short comings related to the study design and execution. http://purl.obolibrary.org/obo/IAO_0000633 materials section http://purl.obolibrary.org/obo/IAO_0000314 document part materials A part of a document about the materials required to reproduce the content of the document. http://purl.obolibrary.org/obo/IAO_0000634 notes section http://purl.obolibrary.org/obo/IAO_0000314 document part notes A part of a document containing typically short notes about the document itself and/or the authors. Often the notes section contains subsections related to funding, competing interests, ethical approval, etc. http://purl.obolibrary.org/obo/IAO_0000637 pre-publication history section http://purl.obolibrary.org/obo/IAO_0000314 document part pre-publication history A part of the document about the publication history of a document. This section typically details dates of document submission to a journal and dates of any re-submissions as well as reviewer comments and responses to reviewers by the authors. http://purl.obolibrary.org/obo/IAO_0000639 related work section http://purl.obolibrary.org/obo/IAO_0000314 document part related work A part of a document about work in other publications that is relevant to the content of the document. http://purl.obolibrary.org/obo/IAO_0000641 requirements section http://purl.obolibrary.org/obo/IAO_0000314 document part requirements A part of a document about a resource described in the document, e.g. software, that describes the requirements necessary to use the resource, e.g. operating systems, hardware, etc. in the case of a software resource. http://purl.obolibrary.org/obo/IAO_0000644 statistical analysis section http://purl.obolibrary.org/obo/IAO_0000314 document part statistical analysis A part of the document used to describe the statistical methodologies employed in the work presented in the document. http://purl.obolibrary.org/obo/IAO_0000645 tables section http://purl.obolibrary.org/obo/IAO_0000314 document part tables A part of a document that contains one or more tables. http://purl.obolibrary.org/obo/IAO_0000650 database extract, transform, and load process http://purl.obolibrary.org/obo/OBI_0000011 planned process ETL A planned process which takes as input a database and fills another database by extracting concretizations of information entities from the first, transforming them, and loading the transformed concretizations into the second. http://purl.obolibrary.org/obo/DIDEO_00000163 individual human intestinal microsomal fraction http://purl.obolibrary.org/obo/OBI_0000047 processed material individual human intestinal microsomes a processed material that has a centrifuge pellet role resulting from high-speed centrifugation of a human intestine S9 fraction, which is derived from a single donor http://purl.obolibrary.org/obo/DIDEO_00000164 pooled human liver microsomal fraction http://purl.obolibrary.org/obo/OBI_0000047 processed material pooled human liver microsomes a processed material that has a centrifuge pellet role resulting from high-speed centrifugation of a pool of human liver S9 fractions, which is derived from multiple donors http://purl.obolibrary.org/obo/DIDEO_00000165 individual human liver microsomal fraction http://purl.obolibrary.org/obo/OBI_0000047 processed material individual human liver microsomes a processed material that has a centrifuge pellet role resulting from high-speed centrifugation of a human liver S9 fraction, which is derived from a single donor http://purl.obolibrary.org/obo/DIDEO_00000166 pooled human intestinal microsomal fraction http://purl.obolibrary.org/obo/OBI_0000047 processed material pooled human intestinal microsomes a processed material that has a centrifuge pellet role resulting from high-speed centrifugation of a pool of human intestine S9 fractions, which is derived from multiple donors http://purl.obolibrary.org/obo/DIDEO_00000168 baculovirus-insect recombinant protein production host cell http://purl.obolibrary.org/obo/CL_0000010 cultured cell baculovirus-insect cell a cultured cell that is part of a culture derived from an insect and has a recombinant protein production host role http://purl.obolibrary.org/obo/DIDEO_00000170 percent inhibition http://purl.obolibrary.org/obo/IAO_0000109 measurement datum % inhibition a measurement datum that describes the decrease in activity of a transporter or enzyme in the presence of a compound from activity in the control experiment http://purl.obolibrary.org/obo/DIDEO_00000189 293 transfected cell http://purl.obolibrary.org/obo/CLO_0037237 293-derived cell HEK293 transfected cell a 293-derived cell that is a specified output of a transfection http://purl.obolibrary.org/obo/DIDEO_00000190 number of liver donors http://purl.obolibrary.org/obo/APOLLO_SV_00000032 count Number of Livers a count of human beings from whom originate hepatocytes to be used in an investigation http://purl.obolibrary.org/obo/DIDEO_00000125 drug-drug interaction effect http://purl.obolibrary.org/obo/GO_0008150 biological_process A biological process that is the result of a drug-drug interaction. http://purl.obolibrary.org/obo/CHEBI_22715 benzimidazoles http://purl.obolibrary.org/obo/CHEBI_27171 organic heterobicyclic compound An organic heterocyclic compound containing a benzene ring fused to an imidazole ring. http://purl.obolibrary.org/obo/CHEBI_25000 lactone http://purl.obolibrary.org/obo/CHEBI_33308 carboxylic ester Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. http://purl.obolibrary.org/obo/CHEBI_38830 1-benzofurans http://purl.obolibrary.org/obo/CHEBI_35259 benzofurans A member of the class of benzofurans consisting of a 1-benzofuran skeleton and its substituted derivatives thereof. http://purl.obolibrary.org/obo/CHEBI_35222 inhibitor http://purl.obolibrary.org/obo/CHEBI_24432 biological role A substance that diminishes the rate of a chemical reaction. http://purl.obolibrary.org/obo/CHEBI_60004 mixture http://purl.obolibrary.org/obo/CHEBI_59999 chemical substance A mixture is a chemical substance composed of multiple molecules, at least two of which are of a different kind. http://purl.obolibrary.org/obo/CHEBI_6636 magnesium dichloride http://purl.obolibrary.org/obo/CHEBI_51234 magnesium halide A magnesium salt comprising of two chlorine atoms bound to a magnesium atom. http://purl.obolibrary.org/obo/CHEBI_23367 molecular entity http://purl.obolibrary.org/obo/CHEBI_24431 chemical entity Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity. http://purl.obolibrary.org/obo/CHEBI_23677 diazole http://purl.obolibrary.org/obo/CHEBI_68452 azole An azole that is either one of a pair of heterocyclic organic compounds comprising three carbon atoms and two nitrogen atoms arranged in a ring. http://purl.obolibrary.org/obo/CHEBI_24432 biological role http://purl.obolibrary.org/obo/BFO_0000023 role A role played by the molecular entity or part thereof within a biological context. http://purl.obolibrary.org/obo/CHEBI_24532 organic heterocyclic compound http://purl.obolibrary.org/obo/CHEBI_33832 organic cyclic compound A cyclic compound having as ring members atoms of carbon and at least of one other element. http://purl.obolibrary.org/obo/CHEBI_2663 amiodarone http://purl.obolibrary.org/obo/CHEBI_38830 1-benzofurans An organoiodine compound that has formula C25H29I2NO3. http://purl.obolibrary.org/obo/CHEBI_33240 coordination entity http://purl.obolibrary.org/obo/CHEBI_37577 heteroatomic molecular entity An assembly consisting of a central atom (usually metallic) to which is attached a surrounding array of other groups of atoms (ligands). http://purl.obolibrary.org/obo/CHEBI_33285 heteroorganic entity http://purl.obolibrary.org/obo/CHEBI_50860 organic molecular entity A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms. http://purl.obolibrary.org/obo/CHEBI_33675 p-block molecular entity http://purl.obolibrary.org/obo/CHEBI_33579 main group molecular entity A p-block molecular entity is a molecular entity containing one or more atoms of a p-block element. http://purl.obolibrary.org/obo/CHEBI_33832 organic cyclic compound http://purl.obolibrary.org/obo/CHEBI_72695 organic molecule Any organic molecule that consists of atoms connected in the form of a ring. http://purl.obolibrary.org/obo/CHEBI_36357 polyatomic entity http://purl.obolibrary.org/obo/CHEBI_23367 molecular entity Any molecular entity consisting of more than one atom. http://purl.obolibrary.org/obo/CHEBI_36962 organochalcogen compound http://purl.obolibrary.org/obo/CHEBI_33285 heteroorganic entity An organochalcogen compound is a compound containing at least one carbon-chalcogen bond. http://purl.obolibrary.org/obo/CHEBI_37577 heteroatomic molecular entity http://purl.obolibrary.org/obo/CHEBI_36357 polyatomic entity A molecular entity consisting of two or more chemical elements. http://purl.obolibrary.org/obo/CHEBI_47381 diclofenac http://purl.obolibrary.org/obo/CHEBI_33832 organic cyclic compound A monocarboxylic acid consisting of phenylacetic acid having a (2,6-dichlorophenyl)amino group at the 2-position. http://purl.obolibrary.org/obo/CHEBI_68452 azole http://purl.obolibrary.org/obo/CHEBI_38179 monocyclic heteroarene Any monocyclic heteroarene consisting of a five-membered ring containing nitrogen. Azoles can also contain one or more other non-carbon atoms, such as nitrogen, sulfur or oxygen. http://purl.obolibrary.org/obo/CHEBI_38545 rosuvastatin http://purl.obolibrary.org/obo/CHEBI_35972 dihydroxy monocarboxylic acid A dihydroxy monocarboxylic acid that is (6E)-7-{4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl} hept-6-enoic acid carrying two hydroxy substituents at positions 3 and 5 (the 3R,5S-diastereomer). http://purl.obolibrary.org/obo/CHEBI_38561 fluvastatin http://purl.obolibrary.org/obo/CHEBI_60911 racemate A racemate comprising equimolar amounts of (3R,5S)- and (3S,5R)-fluvastatin. An HMG-CoA reductase inhibitor, it is used (often as the corresponding sodium salt) to reduce triglycerides and LDL-cholesterol, and increase HDL-chloesterol, in the treatment of hyperlipidaemia. http://purl.obolibrary.org/obo/CHEBI_6076 itraconazole http://purl.obolibrary.org/obo/CHEBI_38597 triazole A dioxolane that has formula C35H38Cl2N8O4. http://purl.obolibrary.org/obo/CHEBI_63799 4-hydroxytolbutamide http://purl.obolibrary.org/obo/CHEBI_33832 organic cyclic compound A urea that consists of 1-butylurea having a 4-hydroxymethylbenzenesulfonyl group attached at the 3-position. http://purl.obolibrary.org/obo/CHEBI_63840 5'-hydroxyomeprazole http://purl.obolibrary.org/obo/CHEBI_22715 benzimidazoles A sulfoxide that is omeprazole in which one of the methyl hydrogens at position 5 on the pyridine ring is substituted by a hydroxy group. http://purl.obolibrary.org/obo/CHEBI_63859 6-hydroxypaclitaxel http://purl.obolibrary.org/obo/CHEBI_50860 organic molecular entity A taxane diterpenoid that consists of paclitaxel bearing an additional hydroxy substituent at the 6alpha-position. http://purl.obolibrary.org/obo/CHEBI_7772 omeprazole http://purl.obolibrary.org/obo/CHEBI_60911 racemate A racemate comprising equimolar amounts of (R)- and (S)-omeprazole. http://purl.obolibrary.org/obo/PR_000015223 solute carrier organic anion transporter family member 1B1 http://purl.obolibrary.org/obo/CHEBI_36080 protein A solute carrier organic anion transporter family member that is a translation product of the human SLCO1B1 gene or a 1:1 ortholog thereof. http://purl.obolibrary.org/obo/PR_000015224 solute carrier organic anion transporter family member 1B3 http://purl.obolibrary.org/obo/CHEBI_36080 protein A solute carrier organic anion transporter family member that is a translation product of the human SLCO1B3 gene or a 1:1 ortholog thereof. http://purl.obolibrary.org/obo/APOLLO_SV_00000461 drug identifier http://purl.obolibrary.org/obo/IAO_0020000 identifier An identifier that denotes a drug product. http://purl.obolibrary.org/obo/DIDEO_00000124 clinical study http://purl.obolibrary.org/obo/OBI_0000070 assay An assay that is the realization of a concretization of a clinical study design. http://purl.obolibrary.org/obo/DIDEO_00000127 percentage value specification http://purl.obolibrary.org/obo/DIDEO_00000126 ratio value specification A ratio value specification where the relationship between to numbers is expressed as a fraction of 100. http://purl.obolibrary.org/obo/BFO_0000002 continuant http://purl.obolibrary.org/obo/BFO_0000001 entity An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts. http://purl.obolibrary.org/obo/BFO_0000003 occurrent http://purl.obolibrary.org/obo/BFO_0000001 entity An entity that has temporal parts and that happens, unfolds or develops through time. http://purl.obolibrary.org/obo/BFO_0000004 independent continuant http://purl.obolibrary.org/obo/BFO_0000002 continuant A continuant that is a bearer of quality and realizable entity entities, in which other entities inhere and which itself cannot inhere in anything. http://purl.obolibrary.org/obo/BFO_0000005 obsolete dependent continuant http://www.geneontology.org/formats/oboInOwl#ObsoleteClass Obsolete Class A continuant that is either dependent on one or other independent continuant bearers or inheres in or is borne by other entities. http://purl.obolibrary.org/obo/BFO_0000015 process http://purl.obolibrary.org/obo/BFO_0000003 occurrent An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. http://purl.obolibrary.org/obo/BFO_0000017 realizable entity http://purl.obolibrary.org/obo/BFO_0000020 specifically dependent continuant A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances. http://purl.obolibrary.org/obo/BFO_0000020 specifically dependent continuant http://purl.obolibrary.org/obo/BFO_0000002 continuant b is a relational specifically dependent continuant = Def. b is a specifically dependent continuant and there are n > 1 independent continuants c1, … cn which are not spatial regions are such that for all 1 i < j n, ci and cj share no common parts, are such that for each 1 i n, b s-depends_on ci at every time t during the course of b’s existence (axiom label in BFO2 Reference: [131-004]) http://purl.obolibrary.org/obo/BFO_0000023 role http://purl.obolibrary.org/obo/BFO_0000017 realizable entity A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts. http://purl.obolibrary.org/obo/BFO_0000031 generically dependent continuant http://purl.obolibrary.org/obo/BFO_0000002 continuant A continuant that is dependent on one or other independent continuant bearers. For every instance of A requires some instance of (an independent continuant type) B but which instance of B serves can change from time to time. http://purl.obolibrary.org/obo/BFO_0000035 process boundary http://purl.obolibrary.org/obo/BFO_0000003 occurrent p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001]) http://purl.obolibrary.org/obo/BFO_0000040 material entity http://purl.obolibrary.org/obo/BFO_0000004 independent continuant An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time. http://purl.obolibrary.org/obo/BFO_0000140 continuant fiat boundary http://purl.obolibrary.org/obo/BFO_0000141 immaterial entity b is a continuant fiat boundary = Def. b is an immaterial entity that is of zero, one or two dimensions and does not include a spatial region as part. (axiom label in BFO2 Reference: [029-001]) http://purl.obolibrary.org/obo/BFO_0000144 process profile http://purl.obolibrary.org/obo/BFO_0000015 process b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002]) http://purl.obolibrary.org/obo/BFO_0000145 relational quality http://purl.obolibrary.org/obo/BFO_0000019 quality b is a relational quality = Def. for some independent continuants c, d and for some time t: b quality_of c at t & b quality_of d at t. (axiom label in BFO2 Reference: [057-001]) http://purl.obolibrary.org/obo/CLO_0000001 cell line cell http://purl.obolibrary.org/obo/CL_0000010 cultured cell A cultured cell that is part of a cell line - a stable and homogeneous population of cells with a common biological origin and propagation history in culture http://purl.obolibrary.org/obo/CLO_0000031 cell line http://purl.obolibrary.org/obo/OBI_0100060 cultured cell population A cultured cell population that represents a genetically stable and homogenous population of cultured cells that shares a common propagation history (i.e. has been successively passaged together in culture). http://purl.obolibrary.org/obo/GAZ_00000448 geographic location http://purl.obolibrary.org/obo/BFO_0000029 site A reference to a place on the Earth, by its name or by its geographical location. http://purl.obolibrary.org/obo/IAO_0000001 conditional specification http://purl.obolibrary.org/obo/IAO_0000033 directive information entity a directive information entity that specifies what should happen if the trigger condition is fulfilled http://purl.obolibrary.org/obo/IAO_0000003 measurement unit label http://purl.obolibrary.org/obo/IAO_0000009 datum label A measurement unit label is as a label that is part of a scalar measurement datum and denotes a unit of measure. http://purl.obolibrary.org/obo/IAO_0000006 narrative object http://purl.obolibrary.org/obo/IAO_0000030 information content entity A narrative object is an information content entity that is a set of propositions. http://purl.obolibrary.org/obo/IAO_0000007 action specification http://purl.obolibrary.org/obo/IAO_0000033 directive information entity a directive information entity that describes an action the bearer will take http://purl.obolibrary.org/obo/IAO_0000009 datum label http://purl.obolibrary.org/obo/IAO_0000030 information content entity A label is a symbol that is part of some other datum and is used to either partially define the denotation of that datum or to provide a means for identifying the datum as a member of the set of data with the same label http://purl.obolibrary.org/obo/IAO_0000010 software http://purl.obolibrary.org/obo/IAO_0000104 plan specification Software is a plan specification composed of a series of instructions that can be interpreted by or directly executed by a processing unit. http://purl.obolibrary.org/obo/IAO_0000012 obsolete2_digital entity http://www.geneontology.org/formats/oboInOwl#ObsoleteClass Obsolete Class A digital entity is an information entity which is a collection of bits that can be interpreted by a computer. Two digital entities are the same if they are bitwise identical. http://purl.obolibrary.org/obo/IAO_0000013 journal article http://purl.obolibrary.org/obo/IAO_0000088 report a report that is published in a journal http://purl.obolibrary.org/obo/IAO_0000015 information carrier http://purl.obolibrary.org/obo/BFO_0000019 quality A quality of an information bearer that imparts the information content http://purl.obolibrary.org/obo/IAO_0000017 model number http://purl.obolibrary.org/obo/IAO_0000028 symbol A model number is an information content entity specifically borne by catalogs, design specifications, advertising materials, inventory systems and similar that is about manufactured objects of the same class. The model number is an alternative term for the class. The manufactered objects may or may not also bear the model number. Model numbers can be encoded in a variety of other information objects, such as bar codes, numerals, or patterns of dots. http://purl.obolibrary.org/obo/IAO_0000019 obsolete2_binary digital entity http://www.geneontology.org/formats/oboInOwl#ObsoleteClass Obsolete Class A binary digital entity is a digital entity that is encoded in a way that is not easily human readable and that contains other than text characters. http://purl.obolibrary.org/obo/IAO_0000024 obsolete_unit of measure http://www.geneontology.org/formats/oboInOwl#ObsoleteClass Obsolete Class a unit of measure is the quality of some material entity compared to which another quality is some multiple of. http://purl.obolibrary.org/obo/IAO_0000025 programming language http://purl.obolibrary.org/obo/IAO_0000104 plan specification A language in which source code is written that is intended to be executed/run by a software interpreter. Programming languages are ways to write instructions that specify what to do, and sometimes, how to do it. http://purl.obolibrary.org/obo/IAO_0000028 symbol http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity that is a mark(s) or character(s) used as a conventional representation of another entity. http://purl.obolibrary.org/obo/IAO_0000029 numeral http://purl.obolibrary.org/obo/IAO_0000028 symbol A symbol that denotes a number. http://purl.obolibrary.org/obo/IAO_0000030 information content entity http://purl.obolibrary.org/obo/BFO_0000031 generically dependent continuant A generically dependent continuant that is about some thing. http://purl.obolibrary.org/obo/IAO_0000031 integer numeral http://purl.obolibrary.org/obo/IAO_0000029 numeral a numeral that denotes an integer http://purl.obolibrary.org/obo/IAO_0000032 scalar measurement datum http://purl.obolibrary.org/obo/IAO_0000109 measurement datum a scalar measurement datum is a measurement datum that is composed of two parts, numerals and a unit label. http://purl.obolibrary.org/obo/IAO_0000033 directive information entity http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity whose concretizations indicate to their bearer how to realize them in a process. http://purl.obolibrary.org/obo/IAO_0000034 time trigger http://purl.obolibrary.org/obo/IAO_0000001 conditional specification revisit? http://purl.obolibrary.org/obo/IAO_0000037 dot plot http://purl.obolibrary.org/obo/IAO_0000038 graph A dot plot is a report graph which is a graphical representation of data where each data point is represented by a single dot placed on coordinates corresponding to data point values in particular dimensions. http://purl.obolibrary.org/obo/IAO_0000038 graph http://purl.obolibrary.org/obo/IAO_0000309 diagram A diagram that presents one or more tuples of information by mapping those tuples in to a two dimensional space in a non arbitrary way. http://purl.obolibrary.org/obo/IAO_0000047 obsolete2_text based digital entity http://www.geneontology.org/formats/oboInOwl#ObsoleteClass Obsolete Class A text based digital entity is a digital entity that is encoded so that it only contains text characters. http://purl.obolibrary.org/obo/IAO_0000055 rule http://purl.obolibrary.org/obo/IAO_0000001 conditional specification a rule is an executable which guides, defines, restricts actions http://purl.obolibrary.org/obo/IAO_0000059 obsolete2_report figure http://www.geneontology.org/formats/oboInOwl#ObsoleteClass Obsolete Class A report figure is a report display element that has some aspect of illustration, but may be a composite of figures, images, and other elements http://purl.obolibrary.org/obo/IAO_0000064 algorithm http://purl.obolibrary.org/obo/IAO_0000104 plan specification A plan specification which describes the inputs and output of mathematical functions as well as workflow of execution for achieving an predefined objective. Algorithms are realized usually by means of implementation as computer programs for execution by automata. http://purl.obolibrary.org/obo/IAO_0000065 software interpreter http://purl.obolibrary.org/obo/IAO_0000064 algorithm A software interpreter is a software application that executes some specified input software. http://purl.obolibrary.org/obo/IAO_0000078 curation status specification http://purl.obolibrary.org/obo/IAO_0000102 data about an ontology part The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value. http://purl.obolibrary.org/obo/IAO_0000079 density plot http://purl.obolibrary.org/obo/IAO_0000038 graph A density plot is a report graph which is a graphical representation of data where the tint of a particular pixel corresponds to some kind of function corresponding the the amount of data points relativelly with their distance from the the pixel. http://purl.obolibrary.org/obo/IAO_0000088 report http://purl.obolibrary.org/obo/IAO_0000310 document a document assembled by an author for the purpose of providing information for the audience. A report is the output of a documenting process and has the objective to be consumed by a specific audience. Topic of the report is on something that has completed. A report is not a single figure. Examples of reports are journal article, patent application, grant progress report, case report (not patient record) http://purl.obolibrary.org/obo/IAO_0000091 obsolete_report element http://www.geneontology.org/formats/oboInOwl#ObsoleteClass Obsolete Class A report element is a narrative object in which information is presented and consumed by a human being, and is part of a report. Examples of report elements are figure (dot plot), table, text portion (may include a movie or audio clip on a web page). http://purl.obolibrary.org/obo/IAO_0000093 obsolete2_binary executable http://www.geneontology.org/formats/oboInOwl#ObsoleteClass Obsolete Class Binary executable is a digital entity consisting of the binary representation of machine instructions of a specific processor or they may be binary pseudocode for a virtual machine. A non-source executable file is also called an object program. It is assumed that the binary executable file contains properly-formatted computer instructions. (derived from Wikipedia, Nov 1, 2007) http://purl.obolibrary.org/obo/IAO_0000096 source code module http://purl.obolibrary.org/obo/IAO_0000033 directive information entity A source code module is a directive information entity that specifies, using a programming language, some algorithm. http://purl.obolibrary.org/obo/IAO_0000097 obsolete_report table http://www.geneontology.org/formats/oboInOwl#ObsoleteClass Obsolete Class A report table is a report display element consisting of a matrix of cells layed out in a grid, some set of which are filled with some information content http://purl.obolibrary.org/obo/IAO_0000098 data format specification http://purl.obolibrary.org/obo/IAO_0000033 directive information entity A data format specification is the information content borne by the document published defining the specification. Example: The ISO document specifying what encompasses an XML document; The instructions in a XSD file http://purl.obolibrary.org/obo/IAO_0000100 data set http://purl.obolibrary.org/obo/IAO_0000027 data item A data item that is an aggregate of other data items of the same type that have something in common. Averages and distributions can be determined for data sets. http://purl.obolibrary.org/obo/IAO_0000101 image http://purl.obolibrary.org/obo/IAO_0000308 figure An image is an affine projection to a two dimensional surface, of measurements of some quality of an entity or entities repeated at regular intervals across a spatial range, where the measurements are represented as color and luminosity on the projected on surface. http://purl.obolibrary.org/obo/IAO_0000102 data about an ontology part http://purl.obolibrary.org/obo/IAO_0000027 data item data about an ontology part is a data item about a part of an ontology, for example a term http://purl.obolibrary.org/obo/IAO_0000104 plan specification http://purl.obolibrary.org/obo/IAO_0000033 directive information entity A directive information entity with action specifications and objective specifications as parts that, when concretized, is realized in a process in which the bearer tries to achieve the objectives by taking the actions specified. http://purl.obolibrary.org/obo/IAO_0000105 obsolete2_digital document http://www.geneontology.org/formats/oboInOwl#ObsoleteClass Obsolete Class A digital document is a digital entity consisting of an electronic file which can be rendered into human-readable form by one or more computational applications. The digital document does not refer to the information content of the document but to an instance of the file. http://purl.obolibrary.org/obo/IAO_0000109 measurement datum http://purl.obolibrary.org/obo/IAO_0000027 data item A measurement datum is an information content entity that is a recording of the output of a measurement such as produced by a device. http://purl.obolibrary.org/obo/IAO_0000129 version number http://purl.obolibrary.org/obo/IAO_0000028 symbol A version number is an information content entity which is a sequence of characters borne by part of each of a class of manufactured products or its packaging and indicates its order within a set of other products having the same name. http://purl.obolibrary.org/obo/IAO_0000131 serial number http://purl.obolibrary.org/obo/IAO_0000028 symbol A serial number is an information content entity which is a unique sequence of characters borne by part of manufactured product or its packaging that is assigned to each individual in some class of products, and so can serve as a way to identify an individual product within the class. Serial numbers can be encoded in a variety of other information objects, such as bar codes, numerals, or patterns of dots. http://purl.obolibrary.org/obo/IAO_0000140 setting datum http://purl.obolibrary.org/obo/IAO_0000027 data item A settings datum is a datum that denotes some configuration of an instrument. http://purl.obolibrary.org/obo/IAO_0000144 conclusion textual entity http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity that expresses the results of reasoning about a problem, for instance as typically found towards the end of scientific papers. http://purl.obolibrary.org/obo/IAO_0000178 material information bearer http://purl.obolibrary.org/obo/BFO_0000040 material entity A material entity in which a concretization of an information content entity inheres. http://purl.obolibrary.org/obo/IAO_0000179 histogram http://purl.obolibrary.org/obo/IAO_0000038 graph A histogram is a report graph which is a statistical description of a distribution in terms of occurrence frequencies of different event classes. http://purl.obolibrary.org/obo/IAO_0000180 heatmap http://purl.obolibrary.org/obo/IAO_0000038 graph A heatmap is a report graph which is a graphical representation of data where the values taken by a variable(s) are shown as colors in a two-dimensional map. http://purl.obolibrary.org/obo/IAO_0000181 Venn diagram http://purl.obolibrary.org/obo/IAO_0000038 graph A Venn diagram is a report graph showing all hypothetically possible logical relations between a finite collection of sets. http://purl.obolibrary.org/obo/IAO_0000182 obsolete_survival curve http://www.geneontology.org/formats/oboInOwl#ObsoleteClass Obsolete Class A survival curve is a report graph which is a graphical representation of data where the percentage of survival is plotted as a function of time. http://purl.obolibrary.org/obo/IAO_0000183 dendrogram http://purl.obolibrary.org/obo/IAO_0000038 graph A dendrogram is a report graph which is a tree diagram frequently used to illustrate the arrangement of the clusters produced by a clustering algorithm. http://purl.obolibrary.org/obo/IAO_0000185 photograph http://purl.obolibrary.org/obo/IAO_0000101 image A photograph is created by projecting an image onto a photosensitive surface such as a chemically treated plate or film, CCD receptor, etc. http://purl.obolibrary.org/obo/IAO_0000186 photographic print http://purl.obolibrary.org/obo/IAO_0000178 material information bearer A photographic print is a material entity upon which a photograph generically depends. http://purl.obolibrary.org/obo/IAO_0000225 obsolescence reason specification http://purl.obolibrary.org/obo/IAO_0000102 data about an ontology part The reason for which a term has been deprecated. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value. http://purl.obolibrary.org/obo/IAO_0000301 citation http://purl.obolibrary.org/obo/IAO_0000300 textual entity a textual entity intended to identify a particular publication http://purl.obolibrary.org/obo/IAO_0000302 author identification http://purl.obolibrary.org/obo/IAO_0000590 written name A textual entity intended to identify a particular author http://purl.obolibrary.org/obo/IAO_0000303 institutional identification http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity intended to identify a particular institution http://purl.obolibrary.org/obo/IAO_0000304 caption http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity that describes a figure http://purl.obolibrary.org/obo/IAO_0000305 document title http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity that names a document http://purl.obolibrary.org/obo/IAO_0000306 table http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity that contains a two-dimensional arrangement of texts repeated at regular intervals across a spatial range, such that the spatial relationships among the constituent texts expresses propositions http://purl.obolibrary.org/obo/IAO_0000307 table of abbreviations http://purl.obolibrary.org/obo/IAO_0000306 table A table where the constituent texts are abbreviations and their expansions http://purl.obolibrary.org/obo/IAO_0000308 figure http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity consisting of a two dimensional arrangement of information content entities such that the arrangement itself is about something. http://purl.obolibrary.org/obo/IAO_0000309 diagram http://purl.obolibrary.org/obo/IAO_0000308 figure A figure that expresses one or more propositions http://purl.obolibrary.org/obo/IAO_0000310 document http://purl.obolibrary.org/obo/IAO_0000030 information content entity A collection of information content entities intended to be understood together as a whole http://purl.obolibrary.org/obo/IAO_0000311 publication http://purl.obolibrary.org/obo/IAO_0000310 document A document that has been accepted by a publisher http://purl.obolibrary.org/obo/IAO_0000313 patent http://purl.obolibrary.org/obo/IAO_0000310 document A document that has been accepted by a patent authority http://purl.obolibrary.org/obo/IAO_0000314 document part http://purl.obolibrary.org/obo/IAO_0000030 information content entity an information content entity that is part of a document http://purl.obolibrary.org/obo/IAO_0000315 abstract http://purl.obolibrary.org/obo/IAO_0000314 document part A summary of the entire document that is substantially smaller than the document it summarizes. It is about the document it summarizes. http://purl.obolibrary.org/obo/IAO_0000320 references section http://purl.obolibrary.org/obo/IAO_0000314 document part A part of a document that has citations as parts http://purl.obolibrary.org/obo/IAO_0000321 author list http://purl.obolibrary.org/obo/IAO_0000314 document part part of a document that enumerates the authors of the document http://purl.obolibrary.org/obo/IAO_0000322 institution list http://purl.obolibrary.org/obo/IAO_0000314 document part part of a document that has parts that are institution identifications associated with the authors of the document http://purl.obolibrary.org/obo/IAO_0000327 table of contents http://purl.obolibrary.org/obo/IAO_0000306 table A table that relates document parts to specific locations in a document (usually page numbers). This is also a document part (subsumption there should be inferred). http://purl.obolibrary.org/obo/IAO_0000328 table of figures http://purl.obolibrary.org/obo/IAO_0000306 table A table that relates figures in a document to specific locations in that document (usually page numbers). This is also a document part (subsumption there should be inferred). http://purl.obolibrary.org/obo/IAO_0000329 running title http://purl.obolibrary.org/obo/IAO_0000305 document title A shorter version of a document title http://purl.obolibrary.org/obo/IAO_0000330 copyright section http://purl.obolibrary.org/obo/IAO_0000314 document part A document part that describes legal restrictions on making or distributing copies of the document http://purl.obolibrary.org/obo/IAO_0000400 cartesian spatial coordinate datum http://purl.obolibrary.org/obo/IAO_0000027 data item A cartesian spatial coordinate datum is a representation of a point in a spatial region, in which equal changes in the magnitude of a coordinate value denote length qualities with the same magnitude http://purl.obolibrary.org/obo/IAO_0000401 one dimensional cartesian spatial coordinate datum http://purl.obolibrary.org/obo/IAO_0000400 cartesian spatial coordinate datum A cartesion spatial coordinate datum that uses one value to specify a position along a one dimensional spatial region http://purl.obolibrary.org/obo/IAO_0000402 two dimensional cartesian spatial coordinate datum http://purl.obolibrary.org/obo/IAO_0000400 cartesian spatial coordinate datum A cartesion spatial coordinate datum that uses two values to specify a position within a two dimensional spatial region http://purl.obolibrary.org/obo/IAO_0000403 three dimensional cartesian spatial coordinate datum http://purl.obolibrary.org/obo/IAO_0000400 cartesian spatial coordinate datum A cartesion spatial coordinate datum that uses three values to specify a position within a three dimensional spatial region http://purl.obolibrary.org/obo/IAO_0000408 length measurement datum http://purl.obolibrary.org/obo/IAO_0000032 scalar measurement datum A scalar measurement datum that is the result of measurement of length quality http://purl.obolibrary.org/obo/IAO_0000409 denotator type http://purl.obolibrary.org/obo/IAO_0000102 data about an ontology part A denotator type indicates how a term should be interpreted from an ontological perspective. http://purl.obolibrary.org/obo/IAO_0000414 mass measurement datum http://purl.obolibrary.org/obo/IAO_0000032 scalar measurement datum A scalar measurement datum that is the result of measurement of mass quality http://purl.obolibrary.org/obo/IAO_0000415 hypothesis textual entity http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity that expresses an assertion that is intended to be tested. http://purl.obolibrary.org/obo/IAO_0000416 time measurement datum http://purl.obolibrary.org/obo/IAO_0000032 scalar measurement datum A scalar measurement datum that is the result of measuring a temporal interval http://purl.obolibrary.org/obo/IAO_0000422 postal address http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity that is used as directive to deliver something to a person, or organization http://purl.obolibrary.org/obo/IAO_0000442 author role http://purl.obolibrary.org/obo/BFO_0000023 role A role inhering in a person or organization that is realized when the bearer participates in the work which is the basis of the document, in the writing of the document, and signs it with their name. http://purl.obolibrary.org/obo/IAO_0000443 data item extraction from journal article http://purl.obolibrary.org/obo/OBI_0000011 planned process a planned process in which journal articles are read or processed and data items are extracted, typically for further analysis or indexing http://purl.obolibrary.org/obo/IAO_0000572 documenting http://purl.obolibrary.org/obo/OBI_0000011 planned process a planned process in which a document is created or added to by including the specified input in it. http://purl.obolibrary.org/obo/IAO_0000576 obsolete_establishing a CRID registry http://www.geneontology.org/formats/oboInOwl#ObsoleteClass Obsolete Class a planned process with the objective to establish a system that allows to refer to specific entities of a certain kind and store information about them, by establishing a CRID registry and plan specifications for the process of 1) assigning a CRID and 2) looking up a CRID. http://purl.obolibrary.org/obo/IAO_0000590 written name http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity that denotes a particular in reality. http://purl.obolibrary.org/obo/IAO_0000591 software method http://purl.obolibrary.org/obo/IAO_0000010 software A software method (also called subroutine, subprogram, procedure, method, function, or routine) is software designed to execute a specific task. http://purl.obolibrary.org/obo/IAO_0000592 software module http://purl.obolibrary.org/obo/IAO_0000010 software A software module is software composed of a collection of software methods. http://purl.obolibrary.org/obo/IAO_0000593 software library http://purl.obolibrary.org/obo/IAO_0000010 software A software library is software composed of a collection of software modules and/or software methods in a form that can be statically or dynamically linked to some software application. http://purl.obolibrary.org/obo/IAO_0000594 software application http://purl.obolibrary.org/obo/IAO_0000010 software A software application is software that can be directly executed by some processing unit. http://purl.obolibrary.org/obo/IAO_0000595 software script http://purl.obolibrary.org/obo/IAO_0000010 software A software script is software whose instructions can be executed using a software interpreter. http://purl.obolibrary.org/obo/OBI_0000011 planned process http://purl.obolibrary.org/obo/BFO_0000015 process A processual entity that realizes a plan which is the concretization of a plan specification. http://purl.obolibrary.org/obo/OBI_0000029 centrifuge pellet role http://purl.obolibrary.org/obo/BFO_0000023 role pellet role is a role which inheres in a material entity and is realized by a material separation process using gravitational force generated by a centrifuge in which the material bearing the pellet role is the heavier or heaviest component of the output material.. http://purl.obolibrary.org/obo/OBI_0000034 supernatant role http://purl.obolibrary.org/obo/BFO_0000023 role supernatant role is a role which inheres in a material entity and is realized by a material separation process using gravitational force in which the material bearing the supernatant role is the liquid component of the output material. http://purl.obolibrary.org/obo/OBI_0000047 processed material http://purl.obolibrary.org/obo/BFO_0000040 material entity Is a material entity that is created or changed during material processing. http://purl.obolibrary.org/obo/OBI_0000066 investigation http://purl.obolibrary.org/obo/OBI_0000011 planned process a planned process that consists of parts: planning, study design execution, documentation and which produce conclusion(s). http://purl.obolibrary.org/obo/OBI_0000067 evaluant role http://purl.obolibrary.org/obo/BFO_0000023 role a role that inheres in a material entity that is realized in an assay in which data is generated about the bearer of the evaluant role http://purl.obolibrary.org/obo/OBI_0000272 protocol http://purl.obolibrary.org/obo/IAO_0000033 directive information entity A plan specification which has sufficient level of detail and quantitative information to communicate it between investigation agents, so that different investigation agents will reliably be able to independently reproduce the process. http://purl.obolibrary.org/obo/OBI_0000427 enzyme http://purl.obolibrary.org/obo/BFO_0000040 material entity (protein or rna) or has_part (protein or rna) and has_function some GO:0003824 (catalytic activity) http://purl.obolibrary.org/obo/OBI_0000444 target of material addition role http://purl.obolibrary.org/obo/BFO_0000023 role target of material addition role is a role realized by an entity into which a material is added in a material addition process http://purl.obolibrary.org/obo/OBI_0000471 study design execution http://purl.obolibrary.org/obo/OBI_0000011 planned process a planned process that carries out a study design http://purl.obolibrary.org/obo/OBI_0000571 manufacturer role http://purl.obolibrary.org/obo/BFO_0000023 role Manufacturer role is a role which inheres in a person or organization and which is realized by a manufacturing process. http://purl.obolibrary.org/obo/OBI_0000967 container http://purl.obolibrary.org/obo/OBI_0000968 device A device that can be used to restrict the location of material entities over time http://purl.obolibrary.org/obo/OBI_0001148 gene knock out http://purl.obolibrary.org/obo/OBI_0600043 genetic transformation a genetic transformation that renders a gene non-functional, e.g. due to a point mutation, or the removal of all, or part of, the gene using recombinant methods. http://purl.obolibrary.org/obo/OBI_0001152 transfection http://purl.obolibrary.org/obo/OBI_0600043 genetic transformation a genetic transformation which relies on the use of physical, electrical and chemical phenomena to introduce DNA or RNA into a cell http://purl.obolibrary.org/obo/OBI_0001180 half maximal effective concentration (EC50) http://purl.obolibrary.org/obo/IAO_0000032 scalar measurement datum half maximal effective concentration (EC50) is a scalar measurement datum corresponding to the concentration of a compound which induces a response halfway between the baseline and maximum after some specified exposure time. http://purl.obolibrary.org/obo/OBI_0001191 half maximal inhibitory concentration (IC50) http://purl.obolibrary.org/obo/IAO_0000032 scalar measurement datum Half maximal inhibitory concentration (IC50) is a scalar measurement datum that measures the effectiveness of a compound to competitively inhibit a given process, and corresponds to the concentration of the compound at which it reaches half of its maximum inhibitory effect. http://purl.obolibrary.org/obo/OBI_0001211 ex vivo design http://purl.obolibrary.org/obo/OBI_0500000 study design A study design where all or part of an organism is removed and studied in vitro, e.g. part of a mouse is removed and cultured in vitro. A cell culture with an established cell line is an in vitro experiment. http://purl.obolibrary.org/obo/OBI_0001285 in vitro design http://purl.obolibrary.org/obo/OBI_0500000 study design A study design that is done in a test tube or a culture dish, e.g. A bacterial invasion assay in an established cell culture. http://purl.obolibrary.org/obo/OBI_0001479 tissue specimen http://purl.obolibrary.org/obo/OBI_0100051 specimen A specimen that derives from an anatomical part or substance arising from an organism. Examples of tissue specimen include tissue, organ, physiological system, blood, or body location (arm). http://purl.obolibrary.org/obo/OBI_0001929 mass value specification http://purl.obolibrary.org/obo/OBI_0001931 scalar value specification A value specification that specifies the mass of some thing. http://purl.obolibrary.org/obo/OBI_0001931 scalar value specification http://purl.obolibrary.org/obo/OBI_0001933 value specification A value specification that consists of two parts: a numeral and a unit label http://purl.obolibrary.org/obo/OBI_0001933 value specification http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity that specifies a value within a classification scheme or on a quantitative scale. http://purl.obolibrary.org/obo/OBI_0100026 organism http://purl.obolibrary.org/obo/BFO_0000040 material entity A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs. http://purl.obolibrary.org/obo/OBI_0100051 specimen http://purl.obolibrary.org/obo/BFO_0000040 material entity A material entity that has the specimen role. http://purl.obolibrary.org/obo/OBI_0300311 observation design http://purl.obolibrary.org/obo/OBI_0500000 study design observation design is a study design in which subjects are monitored in the absence of any active intervention by experimentalists. http://purl.obolibrary.org/obo/OBI_0302886 centrifugation http://purl.obolibrary.org/obo/OBI_0600014 material component separation centrifugation is a process separating molecules by size or density using centrifugal forces generated by a spinning rotor. G-forces of several hundred thousand times gravity are generated in ultracentrifugation http://purl.obolibrary.org/obo/OBI_0302900 group randomization http://purl.obolibrary.org/obo/OBI_0600015 group assignment A group assignment which relies on chance to assign materials to a group of materials in order to avoid bias in experimental set up. http://purl.obolibrary.org/obo/OBI_0500001 clinical study design http://purl.obolibrary.org/obo/OBI_0500000 study design Plan for the precise procedure to be followed in a clinical trial, including planned and actual timing of events, choice of control group, method of allocating treatments, blinding methods; assigns a subject to pass through one or more epochs in the course of a trial. Specific design elements, e.g., crossover, parallel; dose-escalation [Modified from Pocock, Clinical Trials: A Practical Approach] http://purl.obolibrary.org/obo/OBI_0600014 material component separation http://purl.obolibrary.org/obo/OBI_0000094 material processing a material processing in which components of an input material become segregated in space http://purl.obolibrary.org/obo/OBI_1000024 cell pellet http://purl.obolibrary.org/obo/OBI_0000047 processed material A material entity which results from the aggregation of cells produced by the application of centrifugal force to a liquid containing cells in suspension http://purl.obolibrary.org/obo/OGMS_0000090 treatment http://purl.obolibrary.org/obo/OBI_0000011 planned process A processual entity whose completion is hypothesized (by a healthcare provider) to alleviate the signs and symptoms associated with a disorder http://purl.obolibrary.org/obo/PATO_0000122 length http://purl.obolibrary.org/obo/BFO_0000019 quality A 1-D extent quality which is equal to the distance between two points. http://purl.obolibrary.org/obo/PATO_0000125 mass http://purl.obolibrary.org/obo/BFO_0000019 quality A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter. http://purl.obolibrary.org/obo/UO_0000001 length unit http://purl.obolibrary.org/obo/IAO_0000003 measurement unit label A unit which is a standard measure of the distance between two points. http://purl.obolibrary.org/obo/UO_0000002 mass unit http://purl.obolibrary.org/obo/IAO_0000003 measurement unit label A unit which is a standard measure of the amount of matter/energy of a physical object. http://purl.obolibrary.org/obo/UO_0000003 time unit http://purl.obolibrary.org/obo/IAO_0000003 measurement unit label A unit which is a standard measure of the dimension in which events occur in sequence. http://purl.obolibrary.org/obo/DRON_00000001 clinical drug role http://purl.obolibrary.org/obo/BFO_0000023 role the role of a material entity to prevent, diagnose, treat, or study disease and/or its effects http://purl.obolibrary.org/obo/APOLLO_SV_00000032 count http://purl.obolibrary.org/obo/IAO_0000109 measurement datum A measurement datum that is the output of counting. http://purl.obolibrary.org/obo/CHEBI_13389 NAD http://purl.obolibrary.org/obo/CHEBI_33833 heteroarene Abbreviation for nicotinamide-adenine dinucleotide when its oxidation state is unknown or unspecified. It is used in metabolic pathways like glycolysis and citric acid cycle. http://purl.obolibrary.org/obo/CHEBI_15822 17alpha-estradiol 3-glucosiduronic acid http://purl.obolibrary.org/obo/CHEBI_36963 organooxygen compound A steroid glucosiduronic acid having 17alpha-estradiol as the steroid component. http://purl.obolibrary.org/obo/CHEBI_15986 polynucleotide http://purl.obolibrary.org/obo/CHEBI_33695 information biomacromolecule A nucleobase-containing molecular entity with a polymeric structure comprised of a linear sequence of 13 or more nucleotide residues. http://purl.obolibrary.org/obo/CHEBI_16474 NADPH http://purl.obolibrary.org/obo/CHEBI_33833 heteroarene NADPH is the reduced form of NADP+; used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent. http://purl.obolibrary.org/obo/CHEBI_16908 NADH http://purl.obolibrary.org/obo/CHEBI_13389 NAD A coenzyme found in all living cells; consists of two nucleotides joined through their 5'-phosphate groups, with one nucleotide containing an adenine base and the other containing nicotinamide. http://purl.obolibrary.org/obo/CHEBI_17200 UDP-alpha-D-glucuronic acid http://purl.obolibrary.org/obo/CHEBI_33833 heteroarene A UDP-sugar having alpha-D-glucuronic acid as the sugar component. http://purl.obolibrary.org/obo/CHEBI_33696 nucleic acid http://purl.obolibrary.org/obo/CHEBI_15986 polynucleotide A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid. http://purl.obolibrary.org/obo/CHEBI_36080 protein http://purl.obolibrary.org/obo/CHEBI_33695 information biomacromolecule A biological macromolecule minimally consisting of one polypeptide chain synthesized at the ribosome. http://purl.obolibrary.org/obo/CHEBI_72695 organic molecule http://purl.obolibrary.org/obo/CHEBI_50860 organic molecular entity Any molecule that consists of at least one carbon atom as part of the electrically neutral entity. http://purl.obolibrary.org/obo/CHEBI_39548 atorvastatin http://purl.obolibrary.org/obo/CHEBI_35972 dihydroxy monocarboxylic acid A dihydroxy monocarboxylic acid that is a member of the drug class known as statins, used primarily for lowering blood cholesterol and for preventing cardiovascular diseases. http://purl.obolibrary.org/obo/CHEBI_40303 lovastatin http://purl.obolibrary.org/obo/CHEBI_18946 delta-lactone A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as a antilipemic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom). http://purl.obolibrary.org/obo/CHEBI_59613 4'-hydroxydiclofenac http://purl.obolibrary.org/obo/CHEBI_33832 organic cyclic compound A monocarboxylic acid that is the 4'-hydroxylated metabolite of diclofenac. http://purl.obolibrary.org/obo/CL_0000010 cultured cell http://purl.obolibrary.org/obo/CL_0000578 experimentally modified cell in vitro A cell in vitro that is or has been maintained or propagated as part of a cell culture. http://purl.obolibrary.org/obo/CL_0000578 experimentally modified cell in vitro http://purl.obolibrary.org/obo/OBI_0000047 processed material A cell in vitro that has undergone physical changes as a consequence of a deliberate and specific experimental procedure. http://purl.obolibrary.org/obo/UBERON_0000467 anatomical system http://purl.obolibrary.org/obo/UBERON_0000465 material anatomical entity Multicellular, connected anatomical structure that has multiple organs as parts and whose parts work together to achieve some shared function. http://purl.obolibrary.org/obo/CHEBI_101278 diltiazem http://purl.obolibrary.org/obo/CHEBI_82814 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the management of angina pectoris and hypertension. http://purl.obolibrary.org/obo/CHEBI_18946 delta-lactone http://purl.obolibrary.org/obo/CHEBI_25000 lactone A lactone having a six-membered lactone ring. http://purl.obolibrary.org/obo/CHEBI_24780 imidazoles http://purl.obolibrary.org/obo/CHEBI_23677 diazole A five-membered organic heterocycle containing two nitrogen atoms at positions 1 and 3, or any of its derivatives; compounds containing an imidazole skeleton. http://purl.obolibrary.org/obo/CHEBI_25212 metabolite http://purl.obolibrary.org/obo/BFO_0000023 role Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. http://purl.obolibrary.org/obo/CHEBI_26979 organic heterotricyclic compound http://purl.obolibrary.org/obo/CHEBI_38166 organic heteropolycyclic compound An organic tricyclic compound in which at least one of the rings of the tricyclic skeleton contains one or more heteroatoms. http://purl.obolibrary.org/obo/CHEBI_28794 coumarin http://purl.obolibrary.org/obo/CHEBI_38166 organic heteropolycyclic compound A chromenone having the keto group located at the 2-position. http://purl.obolibrary.org/obo/CHEBI_33308 carboxylic ester http://purl.obolibrary.org/obo/CHEBI_35701 ester An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl. http://purl.obolibrary.org/obo/CHEBI_33575 carboxylic acid http://purl.obolibrary.org/obo/CHEBI_35605 carbon oxoacid A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid. http://purl.obolibrary.org/obo/CHEBI_33833 heteroarene http://purl.obolibrary.org/obo/CHEBI_24532 organic heterocyclic compound A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2). http://purl.obolibrary.org/obo/CHEBI_36963 organooxygen compound http://purl.obolibrary.org/obo/CHEBI_36962 organochalcogen compound An organochalcogen compound containing at least one carbon-oxygen bond. http://purl.obolibrary.org/obo/CHEBI_50860 organic molecular entity http://purl.obolibrary.org/obo/CHEBI_33582 carbon group molecular entity Any molecular entity that contains carbon. http://purl.obolibrary.org/obo/CHEBI_60911 racemate http://purl.obolibrary.org/obo/CHEBI_60004 mixture A racemate is an equimolar mixture of a pair of enantiomers. http://purl.obolibrary.org/obo/CHEBI_82814 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate http://purl.obolibrary.org/obo/CHEBI_48684 benzothiazepine A lactam that is 2,3-dihydro-1,5-benzothiazepin-4(5H)-one in which positions 2 and 3 are substituted by 4-methoxyphenyl and acetoxy, respectively, while the hydrogen attached to the nitrogen is substituted by a 2-(dimethylamino)ethyl group. http://purl.obolibrary.org/obo/CHEBI_16856 glutathione http://purl.obolibrary.org/obo/CHEBI_36963 organooxygen compound A tripeptide compound consisting of glutamic acid attached via its side chain to the N-terminus of cysteinylglycine. http://purl.obolibrary.org/obo/CHEBI_23965 estradiol http://purl.obolibrary.org/obo/CHEBI_33832 organic cyclic compound A 3-hydroxy steroid that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17. http://purl.obolibrary.org/obo/CHEBI_24669 hydroxy carboxylic acid http://purl.obolibrary.org/obo/CHEBI_33575 carboxylic acid Any carboxylic acid with at least one hydroxy group. http://purl.obolibrary.org/obo/CHEBI_33839 macromolecule http://purl.obolibrary.org/obo/CHEBI_36357 polyatomic entity A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. http://purl.obolibrary.org/obo/CHEBI_35701 ester http://purl.obolibrary.org/obo/CHEBI_36963 organooxygen compound A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter. http://purl.obolibrary.org/obo/CHEBI_33694 biomacromolecule http://purl.obolibrary.org/obo/CHEBI_33839 macromolecule A macromolecule formed by a living organism. http://purl.obolibrary.org/obo/CHEBI_33697 ribonucleic acid http://purl.obolibrary.org/obo/CHEBI_33696 nucleic acid High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins. http://purl.obolibrary.org/obo/CHEBI_3219 bupropion http://purl.obolibrary.org/obo/CHEBI_33832 organic cyclic compound A propanone that is propan-1-one substituted by a tert-butylamino group at position 2 and a 3-chlorophenyl group at position 1. http://purl.obolibrary.org/obo/CHEBI_46081 fluconazole http://purl.obolibrary.org/obo/CHEBI_38597 triazole A member of the class of triazoles that is propan-2-ol substituted at position 1 and 3 by 1H-1,2,4-triazol-1-yl groups and at position 2 by a 2,4-difluorophenyl group. It has been shown to exhibit antifungal activity. http://purl.obolibrary.org/obo/CHEBI_33579 main group molecular entity http://purl.obolibrary.org/obo/CHEBI_23367 molecular entity A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table. http://purl.obolibrary.org/obo/CHEBI_34477 6beta-hydroxytestosterone http://purl.obolibrary.org/obo/CHEBI_36963 organooxygen compound A 17beta-hydroxy steroid that is testosterone bearing an additional hydroxy substituent at the 6beta-position. http://purl.obolibrary.org/obo/CHEBI_4470 dextromethorphan http://purl.obolibrary.org/obo/CHEBI_38163 organic heterotetracyclic compound An organic heterotetracyclic compound that is morphinan substituted by a methoxy group at position 3 and a methyl group at position 7. It is used as an antitussive drug for suppressing cough. http://purl.obolibrary.org/obo/CHEBI_45863 paclitaxel http://purl.obolibrary.org/obo/CHEBI_50860 organic molecular entity A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark. http://purl.obolibrary.org/obo/CHEBI_48339 ketoconazole http://purl.obolibrary.org/obo/CHEBI_24780 imidazoles A N-carbonylpiperazine that has formula C26H28Cl2N4O4. http://purl.obolibrary.org/obo/CHEBI_59999 chemical substance http://purl.obolibrary.org/obo/CHEBI_24431 chemical entity A chemical substance is a portion of matter of constant composition, composed of molecular entities of the same type or of different types. http://purl.obolibrary.org/obo/CHEBI_9150 simvastatin http://purl.obolibrary.org/obo/CHEBI_18946 delta-lactone A fatty acid ester comprising a dihydroxyheptanoic acid unit condensed into a lactone; a partially reduced naphthalene structure; and a 2,2-dimethylbutyric acyl substituent at C17. It is used as a cholesterol-lowering and anti-cardiovascular disease drug. http://purl.obolibrary.org/obo/GO_0005575 cellular_component http://purl.obolibrary.org/obo/BFO_0000040 material entity The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. http://purl.obolibrary.org/obo/GO_0006810 transport http://purl.obolibrary.org/obo/GO_0051234 establishment of localization The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein. http://purl.obolibrary.org/obo/GO_0008152 metabolic process http://purl.obolibrary.org/obo/GO_0008150 biological_process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. http://purl.obolibrary.org/obo/GO_0051234 establishment of localization http://purl.obolibrary.org/obo/GO_0051179 localization Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. http://purl.obolibrary.org/obo/GO_0065007 biological regulation http://purl.obolibrary.org/obo/GO_0008150 biological_process Any process that modulates a measurable attribute of any biological process, quality or function. http://purl.obolibrary.org/obo/UBERON_0000465 material anatomical entity http://purl.obolibrary.org/obo/BFO_0000040 material entity Anatomical entity that has mass. http://purl.obolibrary.org/obo/DIDEO_00000000 potential drug-drug interaction http://purl.obolibrary.org/obo/IAO_0000030 information content entity A potential drug-drug interaction (PDDI) is an information content entity that specifies the possibility of a drug-drug interaction based on either reasonable extrapolation about drug-drug interaction mechanisms or a data item created by clinical studies, clinical observation or physiological experiment. http://purl.obolibrary.org/obo/DIDEO_00000003 observational data item about drug-drug interaction http://purl.obolibrary.org/obo/IAO_0000027 data item A data item that is about a drug-drug interaction and the creation of which was triggered by an observation outside a controlled context (e.g. a clinical trial). http://purl.obolibrary.org/obo/DIDEO_00000004 physiological observation from clinical study data item http://purl.obolibrary.org/obo/IAO_0000027 data item A data item that is about a biological process and that is the specified output of a clinical study. http://purl.obolibrary.org/obo/DIDEO_00000005 data item from extrapolation http://purl.obolibrary.org/obo/IAO_0000027 data item A data item that is the output of a process of estimating, beyond the original observation range, the value of a variable on the basis of its relationship with another variable. http://purl.obolibrary.org/obo/DIDEO_00000006 gastrointestinal functioning http://purl.obolibrary.org/obo/GO_0008150 biological_process A biological process that realizes the function of the gastrointestinal system (or any organ that is a part of it.). This includes digestion of ingested substances, absorption and eliminating waste. http://purl.obolibrary.org/obo/DIDEO_00000009 pharmacokinetic interaction signal http://purl.obolibrary.org/obo/IAO_0000027 data item A data item that is the outcome of running a kinetic model and that states that drug A has some effects on the absorption, metabolism and elimination of drug B. http://purl.obolibrary.org/obo/DIDEO_00000010 bioavailability http://purl.obolibrary.org/obo/BFO_0000016 disposition Bioavailability is a disposition that is borne by a drug product and is realized by the process of a proportion of the active pharmaceutical ingredient in that drug product reaching systemic circulation. http://purl.obolibrary.org/obo/DIDEO_00000011 object drug information http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity that makes a statement about a drug product being an object drug in a drug interaction. http://purl.obolibrary.org/obo/DIDEO_00000012 object drug role http://purl.obolibrary.org/obo/BFO_0000023 role The role that inheres in a drug product or drug ingredient and that is realized by being affected by another drug pharmacokinetically or pharmacodynamically in a drug drug interaction. http://purl.obolibrary.org/obo/DIDEO_00000013 precipitant drug role http://purl.obolibrary.org/obo/BFO_0000023 role The role that inheres in a drug product or drug ingredient that is realized by affecting another drug pharmacokinetically or pharmacodynamically in a drug drug interaction. http://purl.obolibrary.org/obo/DIDEO_00000014 precipitant drug information http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity that makes a statement about a drug product being an precipitant drug in a drug interaction. http://purl.obolibrary.org/obo/DIDEO_00000015 metabolic potential drug-drug interaction http://purl.obolibrary.org/obo/DIDEO_00000000 potential drug-drug interaction A potential drug drug interaction that is about a drug metabolism. http://purl.obolibrary.org/obo/DIDEO_00000016 narrow therapeutic index http://purl.obolibrary.org/obo/BFO_0000016 disposition A disposition inhering in a drug product that when realized is realized by processes that negatively affect the safety or the efficacy of the drug product, or increase its toxicity.. http://purl.obolibrary.org/obo/DIDEO_00000017 metabolism inhibition potential drug-drug interaction http://purl.obolibrary.org/obo/DIDEO_00000015 metabolic potential drug-drug interaction A metabolism induction potential drug-drug interaction that is about an decrease of metabolic activity because of either a decreased expression of the enzyme or inference with how the enzyme contributes to the metabolic process. http://purl.obolibrary.org/obo/DIDEO_00000018 metabolism induction potential drug-drug interaction http://purl.obolibrary.org/obo/DIDEO_00000015 metabolic potential drug-drug interaction A metabolism induction potential drug-drug interaction that is about an increase of an enzyme participating in the metabolic process. http://purl.obolibrary.org/obo/DIDEO_00000021 drug co-administration http://purl.obolibrary.org/obo/OBI_0000011 planned process A planned process of administering more than one drug to the same individual over a specific time interval. http://purl.obolibrary.org/obo/DIDEO_00000023 drug-drug interaction evidence http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity that is about a drug co-administration and is intended to be specified input into the assessment of whether a drug-drug interaction exists or not. http://purl.obolibrary.org/obo/DIDEO_00000024 clinically relevant potential drug-drug interaction http://purl.obolibrary.org/obo/DIDEO_00000000 potential drug-drug interaction A potential drug-drug interaction that is causally linked to an elevated risk of an adverse event that warrants a drug-drug interaction management option. http://purl.obolibrary.org/obo/DIDEO_00000026 drug bioavailability assay http://purl.obolibrary.org/obo/OBI_0000070 assay An assay with the objective to capture information about the bioavailability of an active ingredient in a drug product. http://purl.obolibrary.org/obo/DIDEO_00000030 obsolete_drug-drug interaction effect http://www.geneontology.org/formats/oboInOwl#ObsoleteClass Obsolete Class An entity that is the result of a drug-drug interaction. http://purl.obolibrary.org/obo/DIDEO_00000031 first pass effect disposition http://purl.obolibrary.org/obo/BFO_0000016 disposition It is a disposition that is borne by drug product and is realized by the metabolism of the active pharmaceutical ingredient in that drug product before entering systemic circulation, when ingested. http://purl.obolibrary.org/obo/DIDEO_00000032 drug first pass metabolism assay http://purl.obolibrary.org/obo/OBI_0000070 assay An assay with the objective to capture information about the first pass metabolism of an active ingredient in a drug product. http://purl.obolibrary.org/obo/DIDEO_00000033 first pass metabolism measurement datum http://purl.obolibrary.org/obo/IAO_0000032 scalar measurement datum A scalar measurement datum that is the specified outcome of a drug first pass metabolism assay. http://purl.obolibrary.org/obo/DIDEO_00000034 absorbability http://purl.obolibrary.org/obo/BFO_0000016 disposition Absorbability is a disposition that is borne by a material entity that if realized is realized by the material entity taken up by another material entity in a different state of matter. http://purl.obolibrary.org/obo/DIDEO_00000035 drug absorbability assay http://purl.obolibrary.org/obo/OBI_0000070 assay An assay with the objective to capture information about the absorbability of an active ingredient in a drug product. http://purl.obolibrary.org/obo/DIDEO_00000037 drug maximum concentration assay http://purl.obolibrary.org/obo/OBI_0000070 assay An assay that measures the maximum concentration of an active ingredient of a drug product in a specified compartment of the body of an organism after the first dose of the drug product has been administered. http://purl.obolibrary.org/obo/DIDEO_00000039 primary total clearance enzyme role http://purl.obolibrary.org/obo/BFO_0000023 role A role that is borne by the enzyme responsible for 50% or more of the active pharmaceutic ingredient or metabolite’s total clearance from the body. The role role is realized by the metabolic process of the active pharmaceutical ingredient or metabolite. http://purl.obolibrary.org/obo/DIDEO_00000040 primary metabolic clearance enzyme role http://purl.obolibrary.org/obo/BFO_0000023 role A role that is borne by the enzyme responsible for 50% or more of the active pharmaceutic ingredient or metabolite’s total metabolic clearance from the body. http://purl.obolibrary.org/obo/DIDEO_00000042 drug-drug interaction description from drug package insert http://purl.obolibrary.org/obo/DIDEO_00000001 drug-drug interaction description A drug-drug interaction description that is part of a drug package insert. http://purl.obolibrary.org/obo/DIDEO_00000043 drug-drug interaction description from FDA label information http://purl.obolibrary.org/obo/DIDEO_00000042 drug-drug interaction description from drug package insert A drug-drug interaction description from a drug package insert for an FDA approved drug. http://purl.obolibrary.org/obo/DIDEO_00000044 drug package insert http://purl.obolibrary.org/obo/IAO_0000310 document A document that is provided along with a medication and that gives additional information about that medication. http://purl.obolibrary.org/obo/DIDEO_00000046 pharmacokinetic area under curve http://purl.obolibrary.org/obo/STATO_0000209 area under curve An area under curve in a plot of concentration of granular part of a drug product in some matrix (medium) against time. http://purl.obolibrary.org/obo/DIDEO_00000047 drug package AUC information http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity that is part of a drug package insert and that is about a pharmacokinetic area under the curve measurement result. http://purl.obolibrary.org/obo/DIDEO_00000048 obsolete_evidence information content entity http://www.geneontology.org/formats/oboInOwl#ObsoleteClass Obsolete Class An information content entity that provides statements or data that are used to support or refute an assertion. http://purl.obolibrary.org/obo/DIDEO_00000050 information about increase of pharmacokinetic area under the curve http://purl.obolibrary.org/obo/DIDEO_00000049 pharmacokinetic area under curve information A pharmacokinetic area under curve information that is about at least 2 area under curve measurments and the time series shows an increase of the area under curve. http://purl.obolibrary.org/obo/DIDEO_00000051 information about decrease of pharmacokinetic area under the curve http://purl.obolibrary.org/obo/DIDEO_00000049 pharmacokinetic area under curve information A pharmacokinetic area under curve information that is about at least 2 area under curve measurments and the time series shows a decrease of the area under curve. http://purl.obolibrary.org/obo/DIDEO_00000052 pharmacokinetic process http://purl.obolibrary.org/obo/GO_0008150 biological_process A biological process that has as a participant a part of a drug product and includes absorption, distribution, metabolism and excretion of that substance. http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity that is used to support or refute an assertion. http://purl.obolibrary.org/obo/DIDEO_00000054 evidence material information http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity that is part of an evidence information content entity and mentions the specified input to an assay. http://purl.obolibrary.org/obo/DIDEO_00000055 evidence data item http://purl.obolibrary.org/obo/IAO_0000027 data item A data item that is part of an evidence information content entity and is the specified output of an assay. http://purl.obolibrary.org/obo/DIDEO_00000082 public adverse event reporting database http://purl.obolibrary.org/obo/IAO_0000100 data set A data set that is structured and stored on a computer and that is publicly available and contains reports of adverse events. http://purl.obolibrary.org/obo/DIDEO_00000087 adverse drug reaction causality evaluation protocol http://purl.obolibrary.org/obo/OBI_0000272 protocol A protocol that specifies methodology to assess the likelihood of a drug to be the cause for an adverse event by answering a set of questions about the drug reaction report. http://purl.obolibrary.org/obo/DIDEO_00000091 fold http://purl.obolibrary.org/obo/UO_0000190 ratio A dimensionless ratio unit which describes the relation between the two numbers x and y by giving the multiplier necessary to make x equal to y. http://purl.obolibrary.org/obo/DIDEO_00000092 pharmacokinetic parameter ratio directionality http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity that is part of a pharmacokinetic parameter ratio and that describes whether the relationship between the numbers of the ratio is a positive or a negative one. http://purl.obolibrary.org/obo/DIDEO_00000095 pharmacokinetic parameter ratio http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity that describes the relationship between the mean (arithmetic and geometric) of measurements of a pharmacokintect parameter for a given drug A in absence of another drug and the mean (arithmetic and geometric) of measurements of a pharmacokintect parameter for a given drug A coadministrated with another drug B. http://purl.obolibrary.org/obo/DIDEO_00000097 pharmacokinetic parameter ratio decrease http://purl.obolibrary.org/obo/DIDEO_00000092 pharmacokinetic parameter ratio directionality An pharmacokinetic parameter directionality that describes negative relationship between the numbers of the ratio. http://purl.obolibrary.org/obo/DIDEO_00000098 pharmacokinetic parameter ratio increase http://purl.obolibrary.org/obo/DIDEO_00000092 pharmacokinetic parameter ratio directionality An pharmacokinetic parameter directionality that describes positive relationship between the numbers of the ratio. http://purl.obolibrary.org/obo/DIDEO_00000118 volume of distribution ratio http://purl.obolibrary.org/obo/DIDEO_00000095 pharmacokinetic parameter ratio A pharmacokinetic parameter ratio that describes the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in a bodily fluid for a given active ingredient or metabolite in an organism with and without the inhibiting drug present. It is expressed as a ratio of the volume of distribution with the inhibitor present as the numerator and absent as the denominator. http://purl.obolibrary.org/obo/DIDEO_00000120 efflux ratio http://purl.obolibrary.org/obo/DIDEO_00000095 pharmacokinetic parameter ratio A pharmacokinetic parameter ratio that describes the drug transmembrane transporter activity regarding an active ingredient or a metabolite in an in vitro bi-directional transport assay. It is expressed as a ratio of the apparent permeability in the basal to apical direction as the numerator and apparent permeability in the apical-to-basolateral direction as the denominator. http://purl.obolibrary.org/obo/DIDEO_00000121 net flux ratio http://purl.obolibrary.org/obo/DIDEO_00000095 pharmacokinetic parameter ratio A pharmacokinetic parameter ratio that describes the drug transmembrane transporter activity regarding an active ingredient or a metabolite in an in vitro bi-directional transport assay using transporter transfected cell model. It is expressed as a ratio of the efflux ratio in cells transfected with the transporter as the numerator and efflux ratio in cells not transfected with the transporter (wild type cells) as the denominator. http://purl.obolibrary.org/obo/DRON_00000005 drug product http://purl.obolibrary.org/obo/BFO_0000040 material entity a material entity (1) containing at least one scattered molecular aggregate as part (the active ingredient) and (2) that is the bearer of a clinical drug role http://purl.obolibrary.org/obo/DRON_00000028 active ingredient http://purl.obolibrary.org/obo/DRON_00000030 role of scattered molecular aggregate a role of a scattered molecular aggregate that is part of a drug product that is realized by (1) administration of the drug to an organism followed by (2) some change in the structure or functioning of some part of the organism http://purl.obolibrary.org/obo/DRON_00000030 role of scattered molecular aggregate http://purl.obolibrary.org/obo/BFO_0000023 role a role borne by a scattered molecular aggregate and realized by its grains participating in one or more processes http://purl.obolibrary.org/obo/DRON_00000031 drug administration http://purl.obolibrary.org/obo/OGMS_0000090 treatment a treatment that has as participants an extended organism and a drug product and that results in part of the drug product being located in the extended organism http://purl.obolibrary.org/obo/ERO_0000923 phenotype characterization http://purl.obolibrary.org/obo/OBI_0000070 assay An organismal assay that involves characterization of a phenotype; any observable characteristic or trait of an organism: such as its morphology, development, biochemical or physiological properties, behavior, and products of behavior (such as a bird's nest). Phenotypes result from the expression of an organism's genes as well as the influence of environmental factors and the interactions between the two. http://purl.obolibrary.org/obo/FMA_62970 Portion of plasma http://purl.obolibrary.org/obo/FMA_9669 Portion of body substance Body substance in liquid state contained in the lumen of arterial and venous trees, blood capillary and the cardiac chambers; constitutes the liquid phase of blood. http://purl.obolibrary.org/obo/FMA_9669 Portion of body substance http://purl.obolibrary.org/obo/UBERON_0000465 material anatomical entity Material anatomical entity in a gaseous, liquid, semisolid or solid state, with or without the admixture of cells and biological macromolecules; produced by anatomical structures or derived from inhaled and ingested substances that have been modified by anatomical structures. Examples: saliva, semen, cerebrospinal fluid, respiratory air, urine, feces, blood, plasma, lymph. http://purl.obolibrary.org/obo/IDO_0100872 enzyme substrate role http://purl.obolibrary.org/obo/BFO_0000023 role A role that inheres in a protein or a compound upon which enzyme catalyzes. It is realized in the enzymatic reaction processes, where the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. http://purl.obolibrary.org/obo/INO_0000102 gene expression http://purl.obolibrary.org/obo/GO_0008150 biological_process a biological interaction that uses the information from a gene to synthesize a functional gene product. http://purl.obolibrary.org/obo/OAE_0000001 adverse event http://purl.obolibrary.org/obo/OGMS_0000061 pathological bodily process a pathological bodily process that occurs after a medical intervention. An adverse event is likely caused by the medical intervention; however, such a causal association is not required to be an adverse event. http://purl.obolibrary.org/obo/OAE_0000005 adverse drug event http://purl.obolibrary.org/obo/OAE_0000001 adverse event an adverse event that occurs after a drug administration http://purl.obolibrary.org/obo/OAE_0000055 contraindication http://purl.obolibrary.org/obo/BFO_0000016 disposition A contraindication is a disposition that increases the risk of harm involved in using a particular drug, carrying out a medical procedure, or engaging in a particular activity such that the risk of harm exceeds a threshold. An contraindication serves as a reason to withhold a certain medical treatment. http://purl.obolibrary.org/obo/OAE_0000095 causal adverse drug event http://purl.obolibrary.org/obo/OAE_0000005 adverse drug event a drug adverse event that is caused by a drug adiministration. Here a causal effect is established between the drug administration and the adverse event. http://purl.obolibrary.org/obo/OAE_0000631 severe adverse event http://purl.obolibrary.org/obo/OAE_0000001 adverse event serious adverse event is an adverse event that requires in-patient hospitalization, or prolongation of existing hospitalization, or that causes congenital malformation, or that results in persistent or significant disability or incapacity, or that is life threatening or results in death. http://purl.obolibrary.org/obo/OGMS_0000061 pathological bodily process http://purl.obolibrary.org/obo/OGMS_0000060 bodily process A bodily process that is clinically abnormal. http://purl.obolibrary.org/obo/STATO_0000209 area under curve http://purl.obolibrary.org/obo/IAO_0000109 measurement datum Area under curve is a measurement datum which corresponds to the surface define by the x-axis and bound by the line graph represented in a 2 dimensional plot resulting from an integration or integrative calculus. The interpretation of this measurement datum depends on the variables plotted in the graph http://purl.obolibrary.org/obo/UO_0000000 unit http://purl.obolibrary.org/obo/IAO_0000030 information content entity A unit of measurement is a standardized quantity of a physical quality. http://purl.obolibrary.org/obo/UO_0000190 ratio http://purl.obolibrary.org/obo/UO_0000186 dimensionless unit A dimensionless unit which denotes an amount or magnitude of one quantity relative to another. http://purl.obolibrary.org/obo/DIDEO_00000149 cryopreserved human hepatocyte population http://purl.obolibrary.org/obo/OBI_0100060 cultured cell population a cultured cell population that is derived from hepatocytes isolated from a human being and that has undergone cryopreservation http://purl.obolibrary.org/obo/DIDEO_00000152 freshly isolated human hepatocyte population http://purl.obolibrary.org/obo/OBI_0100060 cultured cell population a cultured cell population that is derived from hepatocytes freshly isolated from a human being http://purl.obolibrary.org/obo/DIDEO_00000153 transgenic animal hepatocyte population http://purl.obolibrary.org/obo/OBI_0100060 cultured cell population a cultured cell population that is derived from cells isolated from the liver of a transgenic organism http://purl.obolibrary.org/obo/DIDEO_00000154 sandwich cultured hepatocyte population http://purl.obolibrary.org/obo/OBI_0100060 cultured cell population a cultured cell population derived from hepatocytes, in which, during the culturing process, the cells occupy a region bound by two parallel plates made of gelled collagen http://purl.obolibrary.org/obo/DIDEO_00000155 human intestinal epithelial cell population http://purl.obolibrary.org/obo/OBI_0100060 cultured cell population a cultured cell population derived from cells isolated from human intestinal epithelium http://purl.obolibrary.org/obo/DIDEO_00000157 HepaRG cell http://purl.obolibrary.org/obo/CLO_0000001 cell line cell an immortal human liver-derived cell line cell that is part of the HepaRG cell line http://purl.obolibrary.org/obo/DIDEO_00000158 Fa2N-4 cell http://purl.obolibrary.org/obo/CLO_0000001 cell line cell an immortal human liver-derived cell line cell that is part of the Fa2N-4 cell line http://purl.obolibrary.org/obo/DIDEO_00000194 MDCK transfected cell http://purl.obolibrary.org/obo/CLO_0007646 MDCK cell an MDCK cell that is the specified output of a transfection http://purl.obolibrary.org/obo/DIDEO_00000197 chlorzoxazone 6-hydroxylation http://purl.obolibrary.org/obo/MOP_0000673 hydroxylation a hydroxylation that has chlorzoxazone as input and 6-hydroxychlorzoxazone as output http://purl.obolibrary.org/obo/DIDEO_00005000 evidence information from drug metabolism induction experiment http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity An evidence information content entity that is about an in vitro assay and that has parts of a drug or drug metabolites, which participate in a POSITIVE regulation of a metabolic process, as its specified input. http://purl.obolibrary.org/obo/CHEBI_17980 3'-phospho-5'-adenylyl sulfate http://purl.obolibrary.org/obo/CHEBI_35701 ester An adenosine bisphosphate having monophosphate groups at the 3'- and 5'-positions and a sulfo group attached to the phosphate at position 5'. http://purl.obolibrary.org/obo/CHEBI_27999 tolbutamide http://purl.obolibrary.org/obo/CHEBI_33675 p-block molecular entity An N-sulfonylurea that consists of 1-butylurea having a tosyl group attached at the 3-position. http://purl.obolibrary.org/obo/CHEBI_35137 hemoprotein http://purl.obolibrary.org/obo/CHEBI_35136 iron protein Conjugated proteins containing heme as the prosthetic group. http://purl.obolibrary.org/obo/CHEBI_3655 chlorzoxazone http://purl.obolibrary.org/obo/CHEBI_27171 organic heterobicyclic compound A member of the class of 1,3-benzoxazoles that is 1,3-benzoxazol-2-ol in which the hydrogen atom at position 5 is substituted by chlorine. A centrally acting muscle relaxant with sedative properties, it is used for the symptomatic treatment of painful muscle spasm. http://purl.obolibrary.org/obo/CHEBI_36562 main-group coordination entity http://purl.obolibrary.org/obo/CHEBI_33240 coordination entity A coordination entity in which the central atom to which the ligands are attached comes from groups 1, 2, 13, 14, 15, 16, 17, or 18 of the periodic table. http://purl.obolibrary.org/obo/CHEBI_9674 triazolam http://purl.obolibrary.org/obo/CHEBI_35501 triazolobenzodiazepine A triazolobenzodiazepine that has formula C17H12Cl2N4. http://purl.obolibrary.org/obo/OBI_0000969 dose specification http://purl.obolibrary.org/obo/IAO_0000033 directive information entity a directive information entity that describes the dose that will be administered to a target http://purl.obolibrary.org/obo/DIDEO_00005004 evidence information from chemical analytic characterization of material http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity An evidence information content entity that is about an assay that has chemical substances as its specific input an that has as its specified output the identification and quantification of chemical constituents http://purl.obolibrary.org/obo/DIDEO_00005005 evidence information from chemical analytic metabolomics of material http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity An evidence information content entity that is about an assay that has as its specific input the identity and quantity of chemical constituents of two or more chemical substances, and has is its specified output an assessment of the similarity of the input chemical substances. http://purl.obolibrary.org/obo/GO_0003674 molecular_function http://purl.obolibrary.org/obo/OGMS_0000060 bodily process Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions. http://purl.obolibrary.org/obo/GO_0003824 catalytic activity http://purl.obolibrary.org/obo/GO_0003674 molecular_function Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. http://purl.obolibrary.org/obo/GO_0008150 biological_process http://purl.obolibrary.org/obo/BFO_0000015 process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end. http://purl.obolibrary.org/obo/GO_0032991 macromolecular complex http://purl.obolibrary.org/obo/GO_0005575 cellular_component A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which the constituent parts function together. http://purl.obolibrary.org/obo/GO_0043234 protein complex http://purl.obolibrary.org/obo/GO_0032991 macromolecular complex A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical. http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process http://purl.obolibrary.org/obo/GO_0008152 metabolic process The chemical reactions and pathways by which individual cells transform chemical substances. http://purl.obolibrary.org/obo/GO_0048518 positive regulation of biological process http://purl.obolibrary.org/obo/GO_0050789 regulation of biological process Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. http://purl.obolibrary.org/obo/GO_0048519 negative regulation of biological process http://purl.obolibrary.org/obo/GO_0050789 regulation of biological process Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. http://purl.obolibrary.org/obo/GO_0050789 regulation of biological process http://purl.obolibrary.org/obo/GO_0065007 biological regulation Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. http://purl.obolibrary.org/obo/GO_0098657 import into cell http://purl.obolibrary.org/obo/GO_0006810 transport The directed movement of some substance from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis. http://purl.obolibrary.org/obo/GO_0019814 immunoglobulin complex http://purl.obolibrary.org/obo/GO_0043234 protein complex A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. http://purl.obolibrary.org/obo/GO_0032409 regulation of transporter activity http://purl.obolibrary.org/obo/GO_0051049 regulation of transport Any process that modulates the activity of a transporter. http://purl.obolibrary.org/obo/GO_0032410 negative regulation of transporter activity http://purl.obolibrary.org/obo/GO_0032409 regulation of transporter activity Any process that stops or reduces the activity of a transporter. http://purl.obolibrary.org/obo/GO_0051179 localization http://purl.obolibrary.org/obo/GO_0008150 biological_process Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation. http://purl.obolibrary.org/obo/GO_0042571 immunoglobulin complex, circulating http://purl.obolibrary.org/obo/GO_0019814 immunoglobulin complex An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component. http://purl.obolibrary.org/obo/GO_0098739 import across plasma membrane http://purl.obolibrary.org/obo/GO_0098657 import into cell The directed movement of some substance from outside of a cell, across the plasma membrane and into the cytosol. http://purl.obolibrary.org/obo/UO_0000186 dimensionless unit http://purl.obolibrary.org/obo/UO_0000000 unit A unit which is a standard measure of physical quantity consisting of only a numerical number without any units. http://purl.obolibrary.org/obo/UO_0000187 percent http://purl.obolibrary.org/obo/UO_0000190 ratio A dimensionless ratio unit which denotes numbers as fractions of 100. http://purl.obolibrary.org/obo/PDRO/PDRO.owl#PDRO_0000125 drug product quantification specification http://purl.obolibrary.org/obo/PDRO/PDRO.owl#PDRO_0000123 dose quantification specification A dose quantification specification that quantifies a dose by referring to the quantity of drug product administered in a dose administration. http://purl.obolibrary.org/obo/PDRO/PDRO.owl#PDRO_0000123 dose quantification specification http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity that specifies how a dose is quantified in a dose administration. http://purl.obolibrary.org/obo/PDRO/PDRO.owl#PDRO_0000124 active ingredient quantification specification http://purl.obolibrary.org/obo/PDRO/PDRO.owl#PDRO_0000123 dose quantification specification A dose quantification specification that quantifies a dose by referring to the quantity of active ingredient administered in a dose administration. http://purl.obolibrary.org/obo/GO_0009892 negative regulation of metabolic process http://purl.obolibrary.org/obo/GO_0065007 biological regulation Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. http://purl.obolibrary.org/obo/GO_0032879 regulation of localization http://purl.obolibrary.org/obo/GO_0050789 regulation of biological process Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location. http://purl.obolibrary.org/obo/GO_0051049 regulation of transport http://purl.obolibrary.org/obo/GO_0032879 regulation of localization Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. http://purl.obolibrary.org/obo/GO_0051051 negative regulation of transport http://purl.obolibrary.org/obo/GO_0051049 regulation of transport Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. http://purl.obolibrary.org/obo/PR_000013030 NADPH--cytochrome P450 reductase http://purl.obolibrary.org/obo/CHEBI_36080 protein A protein that is a translation product of the human POR gene or a 1:1 ortholog thereof. http://purl.obolibrary.org/obo/DIDEO_00000192 tolbutamide methylhydroxylation http://purl.obolibrary.org/obo/MOP_0000673 hydroxylation a hydroxylation that has tolbutamide as input and 4-hydroxytolbutamide as output http://purl.obolibrary.org/obo/DIDEO_00000193 estradiol glucuronosylation http://purl.obolibrary.org/obo/MOP_0000156 glucuronosylation a glucuronosylation that has estradiol as input and has estradiol-3-glucuronide as output http://purl.obolibrary.org/obo/MOP_0000156 glucuronosylation http://purl.obolibrary.org/obo/MOP_0000779 formation of covalent bond Formation of a covalent bond between a substrate and a glucuronosyl group. http://purl.obolibrary.org/obo/MOP_0000543 molecular process http://purl.obolibrary.org/obo/BFO_0000015 process A process in which at least one of the participants is a molecule. http://purl.obolibrary.org/obo/MOP_0000590 dehydrogenation http://purl.obolibrary.org/obo/BFO_0000015 process An oxidation process that involves the removal of adjacent hydrogen atoms, resulting in an increase of bond order. http://purl.obolibrary.org/obo/MOP_0000673 hydroxylation http://purl.obolibrary.org/obo/MOP_0000779 formation of covalent bond Formation of a covalent bond between a substrate and a hydroxy group. http://purl.obolibrary.org/obo/MOP_0001364 demethylation http://purl.obolibrary.org/obo/MOP_0000780 breaking of covalent bond Breaking of a covalent bond between a substrate and a methyl group. http://purl.obolibrary.org/obo/MOP_0001385 deethylation http://purl.obolibrary.org/obo/MOP_0000780 breaking of covalent bond Breaking of a covalent bond between a substrate and an ethyl group. http://purl.obolibrary.org/obo/ERO_0000630 nucleic acid reagent http://purl.obolibrary.org/obo/BFO_0000040 material entity Reagent that is a polymer comprised of nucleotides, each of which consists of three components: a nitrogenous heterocyclic base, which is either a purine or a pyrimidine; a pentose sugar; and a phosphate group. http://purl.obolibrary.org/obo/ERO_0001202 RNA reagent http://purl.obolibrary.org/obo/ERO_0000630 nucleic acid reagent A reagent that is a polymer comprised of RNA nucleotides. http://purl.obolibrary.org/obo/IAO_0000605 abbreviation textual entity http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity listing abbreviations and their expansions that are used in a document. http://purl.obolibrary.org/obo/IAO_0000608 author information textual entity http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity expression information about an author of a document. This information may include biographical information and may discuss how the authors' professional experiences are relevant to the work described in the document. http://purl.obolibrary.org/obo/IAO_0000610 author summary textual entity http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity, distinct from the abstract, that describes the significance and broader context of the document content. The author summary is often written in a non-technical manner and is aimed at both scientists and non-scientist readers, e.g as described in the article submission guidelines for PLoS Genetics (http://journals.plos.org/plosgenetics/s/submission-guidelines). http://purl.obolibrary.org/obo/IAO_0000612 availability textual entity http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity expressing the location of a resource, e.g. software, or the manner in which a resource can be obtained. http://purl.obolibrary.org/obo/IAO_0000614 case report textual entity http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity that expresses a detailed account of a portion of the medical history for a specific patient. http://purl.obolibrary.org/obo/IAO_0000617 conflict of interest textual entity http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity that expresses a situation involving one or more of the authors, or the funding source of a document whereby the authors or funding source stand to potentially gain (typically financially) from the results reported in the document. http://purl.obolibrary.org/obo/IAO_0000619 consent textual entity http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity that documents the consenting process used to enroll patients in a study. http://purl.obolibrary.org/obo/IAO_0000621 ethical approval textual entity http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity that documents the ethical approval of some study design. http://purl.obolibrary.org/obo/IAO_0000624 funding source declaration textual entity http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity documenting the source of funding that supported some study. http://purl.obolibrary.org/obo/IAO_0000626 future directions textual entity http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity expressing ideas regarding future work relevant to work described in a document that could be done. http://purl.obolibrary.org/obo/IAO_0000628 genome announcement textual entity http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity that describes the generation and public release of a novel, draft genome sequence. http://purl.obolibrary.org/obo/IAO_0000629 keyword textual entity http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity listing keywords indicating the major theme(s) of a document. http://purl.obolibrary.org/obo/IAO_0000632 study limitations textual entity http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity addressing a shortcoming or bias of a study design or execution. http://purl.obolibrary.org/obo/IAO_0000635 patients section http://purl.obolibrary.org/obo/IAO_0000314 document part A part of a document about the patients that participated in a study. http://purl.obolibrary.org/obo/IAO_0000636 patients textual entity http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity expressing information regarding the patients used in a study. http://purl.obolibrary.org/obo/IAO_0000638 pre-publication history textual entity http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity that expresses the pre-publication history (submission dates, reviewer comments, etc) for a document, often including a hyperlink to a web page detailing the information. http://purl.obolibrary.org/obo/IAO_0000640 related work textual entity http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity that discusses work from other publications and expresses their relevancy to the content of a document. http://purl.obolibrary.org/obo/IAO_0000642 requirements textual entity http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity that expresses the requirements necessary to use a resource, e.g. software. http://purl.obolibrary.org/obo/IAO_0000643 statistical analysis textual entity http://purl.obolibrary.org/obo/IAO_0000300 textual entity A textual entity documenting statistical analysis tools and techniques employed. http://purl.obolibrary.org/obo/DIDEO_00000123 probe subtrate role http://purl.obolibrary.org/obo/BFO_0000023 role The role that inheres in a chemical substance and that, if realized, is realized by a single, specified metabolic or transport reaction, which is being affected by another chemically substance pharmacokinetically in a drug-drug interaction experiment or natural product-drug interaction. http://purl.obolibrary.org/obo/DIDEO_00000160 human liver cytosolic fraction http://purl.obolibrary.org/obo/OBI_0000047 processed material a processed material that has a supernatant role resulting from high-speed centrifugation of a human liver S9 fraction http://purl.obolibrary.org/obo/DIDEO_00000161 human intestine cytosolic fraction http://purl.obolibrary.org/obo/OBI_0000047 processed material a processed material that has a supernatant role resulting from high-speed centrifugation of a human intestine S9 fraction http://purl.obolibrary.org/obo/DIDEO_00000162 human liver S9 fraction http://purl.obolibrary.org/obo/OBI_0000047 processed material a processed material that has a supernatant role resulting from medium-speed centrifugation of a human liver homogenate http://purl.obolibrary.org/obo/DIDEO_00000167 human intestine S9 fraction http://purl.obolibrary.org/obo/OBI_0000047 processed material a processed material that has a supernatant role resulting from medium-speed centrifugation of a human intestine homogenate http://purl.obolibrary.org/obo/DIDEO_00000169 E. coli recombinant protein production host cell http://purl.obolibrary.org/obo/CL_0000010 cultured cell a cultured cell of the species Escherichia coli that bears a recombinant protein production host role http://purl.obolibrary.org/obo/DIDEO_00000171 midazolam 1'-hydroxylation http://purl.obolibrary.org/obo/MOP_0000673 hydroxylation a hydroxylation that has midazolam as input and 1'-hydroxymidazolam as output http://purl.obolibrary.org/obo/DIDEO_00000172 7-ethoxyresorufin O-deethylation http://purl.obolibrary.org/obo/MOP_0001385 deethylation a deethylation that has 7-ethoxyresorufin as input and resorufin as output http://purl.obolibrary.org/obo/DIDEO_00000173 nifedipine dehydrogenation http://purl.obolibrary.org/obo/MOP_0000590 dehydrogenation a dehydrogenation that has nifedipine as input and has dehydronifedipine as output http://purl.obolibrary.org/obo/DIDEO_00000174 bufuralol 1'-hydroxylation http://purl.obolibrary.org/obo/MOP_0000673 hydroxylation a hydroxylation that has bufuralol as input and 1'-hydroxybufurolol as output http://purl.obolibrary.org/obo/DIDEO_00000175 omeprazole 5-hydroxylation http://purl.obolibrary.org/obo/MOP_0000673 hydroxylation a hydroxylation that has omeprazole as input and has 5-hydroxyomeprazole as output http://purl.obolibrary.org/obo/DIDEO_00000176 bupropion hydroxylation http://purl.obolibrary.org/obo/MOP_0000673 hydroxylation a hydroxylation that has bupropion as input and 1-hydroxybupropion as output http://purl.obolibrary.org/obo/DIDEO_00000177 paclitaxel 6-alpha hydroxylation http://purl.obolibrary.org/obo/MOP_0000673 hydroxylation a hydroxylation that has paclitaxel as input and 6-alpha-hydroxypaclitaxel as output http://purl.obolibrary.org/obo/DIDEO_00000178 phenacetin O-deethylation http://purl.obolibrary.org/obo/MOP_0001385 deethylation a deethylation that has phenacetin as input and acetaminophen as output http://purl.obolibrary.org/obo/DIDEO_00000179 coumarin 7-hydroxylation http://purl.obolibrary.org/obo/MOP_0000673 hydroxylation a hydroxylation that has coumarin as input and has 7-hydroxycoumarin as output http://purl.obolibrary.org/obo/DIDEO_00000180 testosterone 6-beta-hydroxylation http://purl.obolibrary.org/obo/MOP_0000673 hydroxylation a hydroxylation that has testosterone as input and 6-beta-hydroxytestosterone as output http://purl.obolibrary.org/obo/DIDEO_00000181 dextromethorphan O-demethylation http://purl.obolibrary.org/obo/MOP_0001364 demethylation a demethylation that has dextromethorphan as input and has dextrorphan as output http://purl.obolibrary.org/obo/DIDEO_00000182 diclofenac 4'-hydroxylation http://purl.obolibrary.org/obo/MOP_0000673 hydroxylation a hydroxylation that has diclofenac as input and 4'-hydroxydiclofenac as output http://purl.obolibrary.org/obo/DIDEO_00000183 recombinant protein production host role http://purl.obolibrary.org/obo/OBI_0000444 target of material addition role a target of material addition role that is borne by a cultured cell and, if realized, is realized in recombinant protein production http://purl.obolibrary.org/obo/DIDEO_00000184 number of doses in a day http://purl.obolibrary.org/obo/APOLLO_SV_00000032 count a count of administrations of a substance to an organism over a duration of 24 hours http://purl.obolibrary.org/obo/DIDEO_00000185 Hep G2 cell http://purl.obolibrary.org/obo/CLO_0000001 cell line cell an immortal human liver-derived cell line cell that is part of the Hep G2 cell line http://purl.obolibrary.org/obo/DIDEO_00000186 CHO transfected cell http://purl.obolibrary.org/obo/CLO_0002421 CHO cell a CHO cell that is a specified output of a transfection http://purl.obolibrary.org/obo/DIDEO_00000187 Hep G2 transfected cell http://purl.obolibrary.org/obo/DIDEO_00000185 Hep G2 cell a Hep G2 cell that has a target of material addition role and is a specified input of a transfection http://purl.obolibrary.org/obo/DIDEO_00000188 siRNA knockout Caco-2 cell http://purl.obolibrary.org/obo/CLO_0002172 Caco-2 cell a Caco-2 cell that is a specified output of a gene knockout that has specified input siRNA http://purl.obolibrary.org/obo/DIDEO_00000191 diclofenac 4'-hydroxylation http://purl.obolibrary.org/obo/MOP_0000673 hydroxylation a hydroxylation that has diclofenac as input and 4'-hydroxydiclofenac as output http://purl.obolibrary.org/obo/CHMO_0002013 high-speed centrifugation http://purl.obolibrary.org/obo/OBI_0302886 centrifugation A separation method where components of a sample are separated on the basis of their density in a centrifuge according to the centrifugal force they experience. Samples are spun at >5000 rpm. http://purl.obolibrary.org/obo/CHMO_0002914 absorption of material http://purl.obolibrary.org/obo/BFO_0000015 process The process of one material (absorbate) being retained by another (absorption). http://purl.obolibrary.org/obo/DIDEO_00000128 drug concept set identifier http://purl.obolibrary.org/obo/IAO_0020000 identifier An identifier that denotes a set of drug identifiers. http://purl.obolibrary.org/obo/DIDEO_00005002 evidence information from drug transport protein induction experiment http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity An evidence information content entity that is about an assay that realizes an ex vivo design, and that has chemical substances as its specific input, which are the outcome of the INDUCTION of drug component transporter. http://purl.obolibrary.org/obo/CLO_0007331 LLC-PK subscript(1) cell http://purl.obolibrary.org/obo/CLO_0000001 cell line cell LLC-PK subscript(1) http://purl.obolibrary.org/obo/CLO_0007646 MDCK cell http://purl.obolibrary.org/obo/CLO_0000001 cell line cell MDCK http://purl.obolibrary.org/obo/BFO_0000148 zero-dimensional temporal region http://purl.obolibrary.org/obo/BFO_0000008 temporal region temporal instant. http://purl.obolibrary.org/obo/NCBITaxon_9606 Homo sapiens http://purl.obolibrary.org/obo/OBI_0100026 organism man http://purl.obolibrary.org/obo/CLO_0002172 Caco-2 cell http://purl.obolibrary.org/obo/CLO_0000001 cell line cell Caco-2 http://purl.obolibrary.org/obo/CLO_0002421 CHO cell http://purl.obolibrary.org/obo/CLO_0000001 cell line cell Chinese Hamster Ovary cell http://purl.obolibrary.org/obo/CLO_0037237 293-derived cell http://purl.obolibrary.org/obo/CLO_0000001 cell line cell HEK293 http://purl.obolibrary.org/obo/NCBITaxon_8355 Xenopus laevis http://purl.obolibrary.org/obo/OBI_0100026 organism Xenopus laevis (Daudin, 1802) http://purl.obolibrary.org/obo/CHEBI_48684 benzothiazepine http://purl.obolibrary.org/obo/CHEBI_27171 organic heterobicyclic compound http://purl.obolibrary.org/obo/CHEBI_34593 Bufuralol http://purl.obolibrary.org/obo/CHEBI_35259 benzofurans http://purl.obolibrary.org/obo/CHEBI_35972 dihydroxy monocarboxylic acid http://purl.obolibrary.org/obo/CHEBI_35868 hydroxy monocarboxylic acid http://purl.obolibrary.org/obo/CHEBI_27171 organic heterobicyclic compound http://purl.obolibrary.org/obo/CHEBI_38166 organic heteropolycyclic compound http://purl.obolibrary.org/obo/CHEBI_35259 benzofurans http://purl.obolibrary.org/obo/CHEBI_38166 organic heteropolycyclic compound http://purl.obolibrary.org/obo/CHEBI_38163 organic heterotetracyclic compound http://purl.obolibrary.org/obo/CHEBI_38166 organic heteropolycyclic compound http://purl.obolibrary.org/obo/CHEBI_38166 organic heteropolycyclic compound http://purl.obolibrary.org/obo/CHEBI_24532 organic heterocyclic compound http://purl.obolibrary.org/obo/CHEBI_6931 Midazolam http://purl.obolibrary.org/obo/CHEBI_24532 organic heterocyclic compound http://purl.obolibrary.org/obo/CHEBI_7565 nifedipine http://purl.obolibrary.org/obo/CHEBI_24532 organic heterocyclic compound http://purl.obolibrary.org/obo/CHEBI_29133 dextrorphan http://purl.obolibrary.org/obo/CHEBI_33285 heteroorganic entity http://purl.obolibrary.org/obo/CHEBI_33582 carbon group molecular entity http://purl.obolibrary.org/obo/CHEBI_33675 p-block molecular entity http://purl.obolibrary.org/obo/CHEBI_38597 triazole http://purl.obolibrary.org/obo/CHEBI_68452 azole http://purl.obolibrary.org/obo/BFO_0000008 temporal region http://purl.obolibrary.org/obo/BFO_0000003 occurrent http://purl.obolibrary.org/obo/BFO_0000011 spatiotemporal region http://purl.obolibrary.org/obo/BFO_0000003 occurrent http://purl.obolibrary.org/obo/BFO_0000141 immaterial entity http://purl.obolibrary.org/obo/BFO_0000004 independent continuant http://purl.obolibrary.org/obo/BFO_0000009 two-dimensional spatial region http://purl.obolibrary.org/obo/BFO_0000006 spatial region http://purl.obolibrary.org/obo/BFO_0000018 zero-dimensional spatial region http://purl.obolibrary.org/obo/BFO_0000006 spatial region http://purl.obolibrary.org/obo/BFO_0000026 one-dimensional spatial region http://purl.obolibrary.org/obo/BFO_0000006 spatial region http://purl.obolibrary.org/obo/BFO_0000028 three-dimensional spatial region http://purl.obolibrary.org/obo/BFO_0000006 spatial region http://purl.obolibrary.org/obo/BFO_0000038 one-dimensional temporal region http://purl.obolibrary.org/obo/BFO_0000008 temporal region http://purl.obolibrary.org/obo/BFO_0000182 history http://purl.obolibrary.org/obo/BFO_0000015 process http://purl.obolibrary.org/obo/OGMS_0000060 bodily process http://purl.obolibrary.org/obo/BFO_0000015 process http://purl.obolibrary.org/obo/BFO_0000034 function http://purl.obolibrary.org/obo/BFO_0000016 disposition http://purl.obolibrary.org/obo/BFO_0000016 disposition http://purl.obolibrary.org/obo/BFO_0000017 realizable entity http://purl.obolibrary.org/obo/BFO_0000019 quality http://purl.obolibrary.org/obo/BFO_0000020 specifically dependent continuant http://purl.obolibrary.org/obo/CHEBI_24431 chemical entity http://purl.obolibrary.org/obo/BFO_0000040 material entity http://purl.obolibrary.org/obo/BFO_0000024 fiat object part http://purl.obolibrary.org/obo/BFO_0000040 material entity http://purl.obolibrary.org/obo/BFO_0000027 object aggregate http://purl.obolibrary.org/obo/BFO_0000040 material entity http://purl.obolibrary.org/obo/BFO_0000030 object http://purl.obolibrary.org/obo/BFO_0000040 material entity http://purl.obolibrary.org/obo/BFO_0000142 one-dimensional continuant fiat boundary http://purl.obolibrary.org/obo/BFO_0000140 continuant fiat boundary http://purl.obolibrary.org/obo/BFO_0000146 two-dimensional continuant fiat boundary http://purl.obolibrary.org/obo/BFO_0000140 continuant fiat boundary http://purl.obolibrary.org/obo/BFO_0000147 zero-dimensional continuant fiat boundary http://purl.obolibrary.org/obo/BFO_0000140 continuant fiat boundary http://purl.obolibrary.org/obo/BFO_0000006 spatial region http://purl.obolibrary.org/obo/BFO_0000141 immaterial entity http://purl.obolibrary.org/obo/BFO_0000029 site http://purl.obolibrary.org/obo/BFO_0000141 immaterial entity http://purl.obolibrary.org/obo/IAO_0000429 email address http://purl.obolibrary.org/obo/IAO_0000030 information content entity http://purl.obolibrary.org/obo/IAO_0000057 contour plot http://purl.obolibrary.org/obo/IAO_0000038 graph http://purl.obolibrary.org/obo/IAO_0000582 time stamped measurement datum http://purl.obolibrary.org/obo/IAO_0000109 measurement datum http://www.ebi.ac.uk/efo/EFO_0000750 genotyping http://purl.obolibrary.org/obo/OBI_0000070 assay http://purl.obolibrary.org/obo/DIDEO_00000126 ratio value specification http://purl.obolibrary.org/obo/OBI_0001933 value specification http://purl.obolibrary.org/obo/NCBITaxon_451864 Dikarya http://purl.obolibrary.org/obo/OBI_0100026 organism http://purl.obolibrary.org/obo/NCBITaxon_562 Escherichia coli http://purl.obolibrary.org/obo/OBI_0100026 organism http://purl.obolibrary.org/obo/IAO_0000008 obsolete_artifact http://www.geneontology.org/formats/oboInOwl#ObsoleteClass Obsolete Class http://purl.obolibrary.org/obo/IAO_0000018 obsolete_material_entity http://www.geneontology.org/formats/oboInOwl#ObsoleteClass Obsolete Class http://purl.obolibrary.org/obo/IAO_0000128 obsolete_identifier http://www.geneontology.org/formats/oboInOwl#ObsoleteClass Obsolete Class http://purl.obolibrary.org/obo/IAO_0000141 obsolete_digital quality http://www.geneontology.org/formats/oboInOwl#ObsoleteClass Obsolete Class http://purl.obolibrary.org/obo/CHEBI_35134 metalloprotein http://purl.obolibrary.org/obo/CHEBI_36080 protein http://purl.obolibrary.org/obo/PR_000001891 multidrug resistance protein 1 http://purl.obolibrary.org/obo/CHEBI_36080 protein http://purl.obolibrary.org/obo/CHEBI_51234 magnesium halide http://purl.obolibrary.org/obo/CHEBI_33976 magnesium coordination entity http://purl.obolibrary.org/obo/UBERON_0001007 digestive system http://purl.obolibrary.org/obo/UBERON_0000467 anatomical system http://purl.obolibrary.org/obo/CHEBI_34480 7-ethoxyresorufin http://purl.obolibrary.org/obo/CHEBI_25970 phenoxazine http://purl.obolibrary.org/obo/CHEBI_51602 resorufin http://purl.obolibrary.org/obo/CHEBI_25970 phenoxazine http://purl.obolibrary.org/obo/CHEBI_35501 triazolobenzodiazepine http://purl.obolibrary.org/obo/CHEBI_26979 organic heterotricyclic compound http://purl.obolibrary.org/obo/CHEBI_25970 phenoxazine http://purl.obolibrary.org/obo/CHEBI_26979 organic heterotricyclic compound http://purl.obolibrary.org/obo/CHEBI_38179 monocyclic heteroarene http://purl.obolibrary.org/obo/CHEBI_33833 heteroarene http://purl.obolibrary.org/obo/CHEBI_35605 carbon oxoacid http://purl.obolibrary.org/obo/CHEBI_36963 organooxygen compound http://purl.obolibrary.org/obo/CHEBI_35868 hydroxy monocarboxylic acid http://purl.obolibrary.org/obo/CHEBI_24669 hydroxy carboxylic acid http://purl.obolibrary.org/obo/CHEBI_33695 information biomacromolecule http://purl.obolibrary.org/obo/CHEBI_33694 biomacromolecule http://purl.obolibrary.org/obo/CHEBI_33976 magnesium coordination entity http://purl.obolibrary.org/obo/CHEBI_35217 alkaline earth coordination entity http://purl.obolibrary.org/obo/GO_0017144 drug metabolic process http://purl.obolibrary.org/obo/GO_0008152 metabolic process http://purl.obolibrary.org/obo/CHEBI_35136 iron protein http://purl.obolibrary.org/obo/CHEBI_35134 metalloprotein http://purl.obolibrary.org/obo/CHEBI_36074 heme-thiolate protein http://purl.obolibrary.org/obo/CHEBI_35137 hemoprotein http://purl.obolibrary.org/obo/CHEBI_38559 cytochrome P450 http://purl.obolibrary.org/obo/CHEBI_36074 heme-thiolate protein http://purl.obolibrary.org/obo/CHEBI_35217 alkaline earth coordination entity http://purl.obolibrary.org/obo/CHEBI_36562 main-group coordination entity http://purl.obolibrary.org/obo/GO_0009987 cellular process http://purl.obolibrary.org/obo/GO_0008150 biological_process http://purl.obolibrary.org/obo/MOP_0000779 formation of covalent bond http://purl.obolibrary.org/obo/MOP_0000543 molecular process http://purl.obolibrary.org/obo/MOP_0000780 breaking of covalent bond http://purl.obolibrary.org/obo/MOP_0000543 molecular process http://purl.obolibrary.org/obo/BFO_0000001 entity http://www.geneontology.org/formats/oboInOwl#ObsoleteClass Obsolete Class http://purl.obolibrary.org/obo/RO_0002234 has output http://purl.obolibrary.org/obo/RO_0000057 has participant produces p has output c iff c is a participant in p, c is present at the end of p, and c is not present at the beginning of p. http://purl.obolibrary.org/obo/RO_0000079 function of http://purl.obolibrary.org/obo/RO_0000052 characteristic of is function of a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0000080 quality of http://purl.obolibrary.org/obo/RO_0000052 characteristic of quality_of a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0000085 has function http://purl.obolibrary.org/obo/RO_0000053 has characteristic has_function a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0000086 has quality http://purl.obolibrary.org/obo/RO_0000053 has characteristic has_quality a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0002350 member of http://purl.obolibrary.org/obo/BFO_0000050 part of member part of is member of is a mereological relation between a item and a collection. http://purl.obolibrary.org/obo/RO_0000087 has role http://purl.obolibrary.org/obo/RO_0000053 has characteristic has_role a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0002436 molecularly interacts with http://purl.obolibrary.org/obo/RO_0002434 interacts with molecularly binds with An interaction relationship in which the two partners are molecular entities and are executing molecular processes that are directly causally connected. http://purl.obolibrary.org/obo/RO_0002449 molecularly decreases activity of http://purl.obolibrary.org/obo/RO_0002448 molecularly controls inhibits Holds between molecules a and b if and only if a executes a process that directly diminishes a process executed by b. http://purl.obolibrary.org/obo/BFO_0000062 preceded by http://purl.obolibrary.org/obo/RO_0002086 ends after preceded_by x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. http://purl.obolibrary.org/obo/RO_0000081 role of http://purl.obolibrary.org/obo/RO_0000052 characteristic of role_of a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0002233 has input http://purl.obolibrary.org/obo/RO_0000057 has participant consumes p has direct input c iff c is a participant in p, c is present at the start of p, and the state of c is modified during p. http://purl.obolibrary.org/obo/RO_0002215 capable of http://purl.obolibrary.org/obo/RO_0002216 capable of part of has function realized in A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. http://purl.obolibrary.org/obo/RO_0002217 actively participates in http://purl.obolibrary.org/obo/RO_0000056 participates in agent in x actively participates in y if and only if x participates in y and x realizes some active role http://purl.obolibrary.org/obo/RO_0002216 capable of part of http://purl.obolibrary.org/obo/RO_0002500 causal agent in has function in c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p. http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within http://purl.obolibrary.org/obo/RO_0002501 causal relation between processes influences (processual) p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q. http://purl.obolibrary.org/obo/BFO_0000063 precedes http://purl.obolibrary.org/obo/RO_0002222 temporally related to x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. http://purl.obolibrary.org/obo/IAO_0000142 mentions http://purl.obolibrary.org/obo/IAO_0000136 is about An information artifact IA mentions an entity E exactly when it has a component/part that denotes E http://purl.obolibrary.org/obo/IAO_0000219 denotes http://purl.obolibrary.org/obo/IAO_0000136 is about denotes is a primitive, instance-level, relation obtaining between an information content entity and some portion of reality. Denotation is what happens when someone creates an information content entity E in order to specifically refer to something. The only relation between E and the thing is that E can be used to 'pick out' the thing. This relation connects those two together. Freedictionary.com sense 3: To signify directly; refer to specifically http://purl.obolibrary.org/obo/IAO_0000221 is quality measurement of http://purl.obolibrary.org/obo/IAO_0000136 is about m is a quality measurement of q at t when q is a quality there is a measurement process p that has specified output m, a measurement datum, that is about q http://purl.obolibrary.org/obo/IAO_0000413 is duration of http://purl.obolibrary.org/obo/IAO_0000136 is about relates a process to a time-measurement-datum that represents the duration of the process http://purl.obolibrary.org/obo/IAO_0000418 is quality specification of http://purl.obolibrary.org/obo/IAO_0000136 is about a relation between a data item and a quality of a material entity where the material entity is the specified output of a material transformation which achieves an objective specification that indicates the intended value of the specified quality. http://purl.obolibrary.org/obo/IAO_0000581 has time stamp http://purl.obolibrary.org/obo/BFO_0000051 has part relates a time stamped measurement datum to the time measurement datum that denotes the time when the measurement was taken http://purl.obolibrary.org/obo/IAO_0000583 has measurement datum http://purl.obolibrary.org/obo/BFO_0000051 has part relates a time stamped measurement datum to the measurement datum that was measured http://purl.obolibrary.org/obo/OBI_0000293 has_specified_input http://purl.obolibrary.org/obo/RO_0000057 has participant A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of. http://purl.obolibrary.org/obo/OBI_0000295 is_specified_input_of http://purl.obolibrary.org/obo/RO_0000056 participates in A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of. http://purl.obolibrary.org/obo/OBI_0000299 has_specified_output http://purl.obolibrary.org/obo/RO_0000057 has participant A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of. http://purl.obolibrary.org/obo/OBI_0000312 is_specified_output_of http://purl.obolibrary.org/obo/RO_0000056 participates in A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of. http://purl.obolibrary.org/obo/OBI_0001927 specifies value of http://purl.obolibrary.org/obo/IAO_0000136 is about A relation between a value specification and an entity which the specification is about. http://purl.obolibrary.org/obo/OBI_0001938 has value specification http://purl.obolibrary.org/obo/BFO_0000051 has part A relation between an information content entity and a value specification that specifies its value. http://purl.obolibrary.org/obo/OBI_1110060 process is result of http://purl.obolibrary.org/obo/RO_0002087 immediately preceded by is a relationship between a process and a preceding occurrent that directly caused the later one to occur http://purl.obolibrary.org/obo/RO_0002351 has member http://purl.obolibrary.org/obo/BFO_0000051 has part has member is a mereological relation between a collection and an item. http://purl.obolibrary.org/obo/DIDEO_00000027 organismally_begins_to_exist_during http://purl.obolibrary.org/obo/BFO_0000068 begins_to_exist_during there is some extended organism e & there is some temporal region tr & p occupies temporal region tr & p occurs_in e & c begins to exist during p & there is some t ( t part-of tr & c located-in e at t ) http://purl.obolibrary.org/obo/DIDEO_00000041 is substrate of http://purl.obolibrary.org/obo/RO_0002566 causally influences A pharmaeutic ingredient or a metabolite X is the substrate of an enzyme E, iff E catalyzes X to M. http://purl.obolibrary.org/obo/RO_0002333 enabled by http://purl.obolibrary.org/obo/RO_0002328 functionally related to inverse of enables http://purl.obolibrary.org/obo/RO_0002404 causally downstream of http://purl.obolibrary.org/obo/RO_0002427 causally downstream of or within inverse of upstream of http://purl.obolibrary.org/obo/RO_0002412 immediately causally upstream of http://purl.obolibrary.org/obo/RO_0002411 causally upstream of p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p must be an input of q. http://purl.obolibrary.org/obo/RO_0002448 molecularly controls http://purl.obolibrary.org/obo/RO_0002436 molecularly interacts with Holds between molecular entities a and b when the execution of a activates or inhibits the activity of b http://purl.obolibrary.org/obo/RO_0002566 causally influences http://purl.obolibrary.org/obo/RO_0002506 causal relation between material entities Holds between materal entities a and b if the activity of a is causally upstream of the activity of b, or causally upstream of a an activity that modifies b http://purl.obolibrary.org/obo/RO_0000091 has disposition http://purl.obolibrary.org/obo/RO_0000053 has characteristic a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0002411 causally upstream of http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain http://purl.obolibrary.org/obo/RO_0002211 regulates http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within x regulates y if and only if the x is the realization of a function to exert an effect on the frequency, rate or extent of y http://purl.obolibrary.org/obo/RO_0002212 negatively regulates http://purl.obolibrary.org/obo/RO_0002211 regulates x negatively regulates y if and only if the progression of x reduces the frequency, rate or extent of y http://purl.obolibrary.org/obo/RO_0002352 input of http://purl.obolibrary.org/obo/RO_0000056 participates in inverse of has input http://purl.obolibrary.org/obo/RO_0002353 output of http://purl.obolibrary.org/obo/RO_0000056 participates in inverse of has output http://purl.obolibrary.org/obo/RO_0002334 regulated by http://purl.obolibrary.org/obo/RO_0002427 causally downstream of or within inverse of regulates http://purl.obolibrary.org/obo/RO_0002410 causally related to http://purl.obolibrary.org/obo/RO_0002609 related via dependence to This relation groups causal relations between material entities and causal relations between processes http://purl.obolibrary.org/obo/RO_0002500 causal agent in http://purl.obolibrary.org/obo/RO_0002595 causal relation between material entity and a process A relationship between a material entity and a process where the material entity has some causal role that influences the process http://purl.obolibrary.org/obo/RO_0002501 causal relation between processes http://purl.obolibrary.org/obo/RO_0002410 causally related to p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q. http://purl.obolibrary.org/obo/RO_0002595 causal relation between material entity and a process http://purl.obolibrary.org/obo/RO_0002410 causally related to A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity. http://purl.obolibrary.org/obo/RO_0002087 immediately preceded by http://purl.obolibrary.org/obo/BFO_0000062 preceded by starts_at_end_of http://purl.obolibrary.org/obo/RO_0002090 immediately precedes http://purl.obolibrary.org/obo/BFO_0000063 precedes meets http://purl.obolibrary.org/obo/RO_0002327 enables http://purl.obolibrary.org/obo/RO_0002215 capable of has http://purl.obolibrary.org/obo/RO_0002408 directly inhibits http://purl.obolibrary.org/obo/RO_0002212 negatively regulates directly negatively regulates http://purl.obolibrary.org/obo/RO_0002409 indirectly inhibits http://purl.obolibrary.org/obo/RO_0002412 immediately causally upstream of indirectly negatively regulates http://purl.obolibrary.org/obo/DIDEO_00000085 realizes substrate role http://purl.obolibrary.org/obo/BFO_0000055 realizes http://purl.obolibrary.org/obo/RO_0000092 disposition of http://purl.obolibrary.org/obo/RO_0000052 characteristic of http://purl.obolibrary.org/obo/IAO_0000039 has measurement unit label http://purl.obolibrary.org/obo/BFO_0000051 has part http://purl.obolibrary.org/obo/IAO_0000407 has coordinate unit label http://purl.obolibrary.org/obo/BFO_0000051 has part http://purl.obolibrary.org/obo/RO_0002086 ends after http://purl.obolibrary.org/obo/RO_0002222 temporally related to http://purl.obolibrary.org/obo/RO_0002335 negatively regulated by http://purl.obolibrary.org/obo/RO_0002334 regulated by http://purl.obolibrary.org/obo/RO_0002506 causal relation between material entities http://purl.obolibrary.org/obo/RO_0002410 causally related to http://purl.obolibrary.org/obo/RO_0002427 causally downstream of or within http://purl.obolibrary.org/obo/RO_0002501 causal relation between processes http://purl.obolibrary.org/obo/RO_0000052 characteristic of inheres_in a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence. http://purl.obolibrary.org/obo/RO_0000053 has characteristic is bearer of Inverse of characteristic_of http://purl.obolibrary.org/obo/RO_0000056 participates in participates_in a relation between a continuant and a process, in which the continuant is somehow involved in the process http://purl.obolibrary.org/obo/RO_0000057 has participant has_participant a relation between a process and a continuant, in which the continuant is somehow involved in the process http://purl.obolibrary.org/obo/RO_0001000 derives from derives_from a relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity http://purl.obolibrary.org/obo/RO_0001001 derives into derives_into a relation between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity http://purl.obolibrary.org/obo/RO_0001015 location of location_of a relation between two independent continuants, the location and the target, in which the target is entirely within the location http://purl.obolibrary.org/obo/RO_0002000 2D boundary of is boundary of a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity http://purl.obolibrary.org/obo/RO_0002002 has 2D boundary has_2D_boundary a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity http://purl.obolibrary.org/obo/RO_0001025 located in located_in a relation between two independent continuants, the target and the location, in which the target is entirely within the location http://purl.obolibrary.org/obo/BFO_0000051 has part has_part a core relation that holds between a whole and its part http://purl.obolibrary.org/obo/BFO_0000050 part of part_of a core relation that holds between a part and its whole http://purl.obolibrary.org/obo/BFO_0000066 occurs in unfolds_in b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t http://purl.obolibrary.org/obo/RO_0002224 starts with started by x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. http://purl.obolibrary.org/obo/RO_0002230 ends with finished by x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. http://purl.obolibrary.org/obo/BFO_0000067 contains process [copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t http://purl.obolibrary.org/obo/IAO_0000135 obsolete_specifically denotes c specifically denotes r =def r is a portion of reality & c is a particular quality & c depends specifically on some independent continuant b & b acquired c as the result of the achievement of an objective to enable pointing to r repeatedly. Marked means there is a changed or additional quality of the bearer - the quality is the information carrier. Case 1 Memory trace as mark created when reading some description of some friend. The trace can denote. Case 2 Pattern of ink arrayed on paper as mark when writing down a friend's name Case 3 Pattern of magnetic domains on scattered pieces of a hard disk platter as mark when saving a file. http://purl.obolibrary.org/obo/IAO_0000136 is about is_about is a (currently) primitive relation that relates an information artifact to an entity. http://purl.obolibrary.org/obo/IAO_0000417 is quality measured as inverse of the relation of is quality measurement of http://purl.obolibrary.org/obo/IAO_0000419 quality is specified as inverse of the relation of is quality specification of http://purl.obolibrary.org/obo/OBI_0001937 has specified value A relation between a value specification and a number that quantifies it. http://purl.obolibrary.org/obo/RO_0000058 is concretized as A relationship between a generically dependent continuant and a specifically dependent continuant or process, in which the generically dependent continuant depends on some independent continuant or process in virtue of the fact that the specifically dependent continuant or process also depends on that same independent continuant. A generically dependent continuant may be concretized as multiple specifically dependent continuants or processes. http://purl.obolibrary.org/obo/RO_0000059 concretizes A relationship between a specifically dependent continuant or process and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant or process also depends on that same independent continuant. Multiple specifically dependent continuants or processes can concretize the same generically dependent continuant. http://purl.obolibrary.org/obo/BFO_0000117 has occurrent part b has_occurrent_part c = Def. c occurrent_part_of b. (axiom label in BFO2 Reference: [007-001]) http://purl.obolibrary.org/obo/DIDEO_00000028 organismally immediately precedes there is some extended organism e & p1 occurs_in e & p2 occurs_in e & p1 immediately precedes p2 http://purl.obolibrary.org/obo/RO_0002434 interacts with A relationship that holds between two entities in which the processes executed by the two entities are causally connected. http://purl.obolibrary.org/obo/RO_0002214 has prototype x has prototype y if and only if x is an instance of C and y is a prototypical instance of C. For example, every instance of heart, both normal and abnormal is related by the has prototype relation to some instance of a "canonical" heart, which participates in blood circulation. http://purl.obolibrary.org/obo/BFO_0000068 begins_to_exist_during continuant(c) and process(p) and first_time_point(p,t1) and last_time_point(p,t2) and not(exists_at(c,t1)) and exists_at(c,t2) http://purl.obolibrary.org/obo/RO_0002609 related via dependence to A relationship that holds between two entities, where the relationship holds based on the presence or absence of statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes. http://purl.obolibrary.org/obo/BFO_0000054 realized in realized_in http://purl.obolibrary.org/obo/BFO_0000055 realizes http://purl.obolibrary.org/obo/IAO_0000004 has measurement value http://purl.obolibrary.org/obo/IAO_0000220 obsolete_materially denotes http://purl.obolibrary.org/obo/IAO_0000222 obsolete_describes http://purl.obolibrary.org/obo/IAO_0000223 obsolete_represents http://purl.obolibrary.org/obo/IAO_0000404 has x coordinate value http://purl.obolibrary.org/obo/IAO_0000405 has z coordinate value http://purl.obolibrary.org/obo/IAO_0000406 has y coordinate value http://purl.obolibrary.org/obo/RO_0004096 DEPRECATED inheres in http://purl.obolibrary.org/obo/RO_0004097 DEPRECATED bearer of http://purl.obolibrary.org/obo/DIDEO_00000029 is organismally immediately preceded by http://purl.obolibrary.org/obo/DIDEO_00000086 involves substrate http://purl.obolibrary.org/obo/DIDEO_00000090 inhibits-catalyzes metabolism of http://purl.obolibrary.org/obo/DIDEO_00000096 catalyzes a Phase I or Phase II enzymatic reaction involving http://purl.obolibrary.org/obo/RO_0002222 temporally related to http://purl.obolibrary.org/obo/RO_0002328 functionally related to http://www.obofoundry.org/ro/ro.owl#has_proper_part has_proper_part http://www.obofoundry.org/ro/ro.owl#proper_part_of proper_part_of