Term IRI Term label Parent term IRI Parent term label Alternative term Definition http://purl.obolibrary.org/obo/OAE_0000934 coagulopathy AE http://purl.obolibrary.org/obo/MONDO_0013792 intracerebral hemorrhage clotting disorder coagulopathy AE results in the impairment of blood to clot causing ecessive or prolonged bleeding. http://purl.obolibrary.org/obo/OAE_0001551 brain AE http://purl.obolibrary.org/obo/OAE_0000001 adverse event brain disorder AE an adverse event that occurs in brain. http://purl.obolibrary.org/obo/OAE_0002392 brain injury AE https://bio.scai.fraunhofer.de/ontology/epilepsy#structural_etiology structural etiology Traumatic Brain Injury a brain injury AE,  injury to the brain caused by an external force, that results in a brain AE http://purl.obolibrary.org/obo/OBI_0002186 electroencephalography http://purl.obolibrary.org/obo/OBI_0000454 extracellular electrophysiology recording assay EEG An extracellular electrophysiology assay where electrodes are mounted outside the brain (either on the surface of the scalp on onto the brain surface itself during surgery) to measure the electrical field over the external surface. http://purl.obolibrary.org/obo/EUPATH_0011795 blood test http://purl.obolibrary.org/obo/OBI_0000070 assay Blood test a laboratory test that has a blood specimen as specified input http://purl.obolibrary.org/obo/IAO_0000027 data item http://purl.obolibrary.org/obo/IAO_0000030 information content entity data a data item is an information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements. http://purl.obolibrary.org/obo/OBI_0000070 assay http://purl.obolibrary.org/obo/OBI_0000011 planned process scientific observation A planned process with the objective to produce information about some evaluant http://purl.obolibrary.org/obo/OBI_0000094 material processing http://purl.obolibrary.org/obo/ERO_0000007 technique material transformation A planned process which results in physical changes in a specified input material http://purl.obolibrary.org/obo/OBI_0000968 device http://purl.obolibrary.org/obo/OBI_0000047 processed material instrument A material entity that is designed to perform a function in a scientific investigation, but is not a reagent. http://purl.obolibrary.org/obo/OAE_0000001 adverse event http://purl.obolibrary.org/obo/OGMS_0000061 pathological bodily process adverse reaction a pathological bodily process that occurs after a medical intervention. An adverse event is likely caused by the medical intervention; however, such a causal association is not required to be an adverse event. http://purl.obolibrary.org/obo/OMIABIS_0001008 comorbidity http://purl.obolibrary.org/obo/OGMS_0000073 diagnosis secondary infection, nosocomial infection A diagnosis that is the outcome of a diagnostic process targeting a second or additional health problem. http://purl.obolibrary.org/obo/MFOMD_0000211 thought disorder (TD) http://purl.obolibrary.org/obo/MFOMD_0000024 pathological mental process formal thought disorder (FTD) Refers to disorganized thinking as evidenced by disorganized speech. http://purl.obolibrary.org/obo/MF_0000013 thinking http://purl.obolibrary.org/obo/MF_0000020 mental process act of thinking a mental process that involves the manipulation of mental language and/or mental images http://purl.obolibrary.org/obo/MF_0000059 daydreaming http://purl.obolibrary.org/obo/NCIT_C35470 Behavioral Disorder act of daydreaming Short-term detachment from one's immediate surroundings, during which a person's contact with reality is blurred and partially substituted by a visionary fantasy, especially one of happy, pleasant thoughts, hopes or ambitions, imagined as coming to pass, and experienced while awake. http://purl.obolibrary.org/obo/ERO_0001071 cerebro-spinal tap http://purl.obolibrary.org/obo/OBI_0000094 material processing Spinal tap A technique used to collect cerebrospinal fluid (CSF) from an organism, which involves inserting a needle between the third and fourth lumbar vertebrae in the back and extracting a sample of fluid. http://purl.obolibrary.org/obo/ERO_0001183 next generation DNA sequencing http://purl.obolibrary.org/obo/OBI_0000626 DNA sequencing Sequencing, high-throughput nucleotide A DNA sequencing technique that became commercially available in 2004 and is used by specific commercial platforms that embody a complex interplay of enzymology, chemistry, high-resolution optics, hardware, and software engineering. These instruments allow highly streamlined sample preparation steps prior to DNA sequencing, which provides a significant time savings and a minimal requirement for associated equipment in comparison to the highly automated, multistep pipelines necessary for clone-based high-throughput sequencing. Each technology amplifies single strands of a fragment library and perform sequencing reactions on the amplified strands. The fragment libraries are obtained by annealing platform-specific linkers to blunt-ended fragments generated directly from a genome or DNA source of interest. Because the presence of adapter sequences means that the molecules then can be selectively amplified by PCR, and no bacterial cloning step is required to amplify the genomic fragment in a bacterial intermediate as is done in traditional sequencing approaches. http://purl.obolibrary.org/obo/ERO_0001235 magnetic resonance imaging http://purl.obolibrary.org/obo/ERO_0001292 physiological assay MRI A physiological assay that uses nuclear magnetic resonance of protons to produce proton density images. http://purl.obolibrary.org/obo/ERO_0001236 magnetic resonance spectroscopy http://purl.obolibrary.org/obo/ERO_0001292 physiological assay MRS A physiological assay that complements magnetic resonance imaging (MRI) as a non-invasive means for the characterization of tissue. While MRI uses the signal from hydrogen protons to form anatomic images, proton MRS uses this information to determine the concentration of brain metabolites such as N-acetyl aspartate (NAA), choline (Cho), creatine (Cr) and lactate in the tissue examined. http://purl.obolibrary.org/obo/ERO_0001351 single photon emission computed tomography http://purl.obolibrary.org/obo/ERO_0001312 imaging technique SPECT An imaging technique, in which a gamma camera rotates around the patient and takes pictures from many angles, and a tomographic (cross-sectional) image is generated. http://purl.obolibrary.org/obo/ERO_0001508 karyotyping http://purl.obolibrary.org/obo/ERO_0000833 molecular assay Chromosomal analysis A molecular assay used to determine the number and appearance of chromosomes in the nucleus of a eukaryotic cell. http://purl.obolibrary.org/obo/ERO_0001764 polysomnography http://purl.obolibrary.org/obo/ERO_0001292 physiological assay Sleep study A physiological assay used in the study of sleep and as a diagnostic tool in sleep medicine. http://purl.obolibrary.org/obo/ERO_0001830 positron emission tomography http://purl.obolibrary.org/obo/ERO_0001312 imaging technique PET An imaging technique that produces a three-dimensional image or picture of functional processes in the body. The system detects pairs of gamma rays emitted indirectly by a positron-emitting radionuclide (tracer), which is introduced into the body on a biologically active molecule. Three-dimensional images of tracer concentration within the body are then constructed by computer analysis. http://purl.obolibrary.org/obo/ERO_0002016 whole genome sequencing http://purl.obolibrary.org/obo/ERO_0001286 nucleic acid assay whole genome sequence analysis A genotyping assay that determines the complete DNA sequence of a cell or organism's genome at a single time. http://purl.obolibrary.org/obo/ERO_0002178 functional magnetic resonance imaging http://purl.obolibrary.org/obo/ERO_0001235 magnetic resonance imaging functional MRI A magnetic resonance imaging technique that measures brain activity by detecting associated changes in blood flow. The procedure is similar to MRI but uses the change in magnetization between oxygen-rich and oxygen-poor blood as its basic measure. http://purl.obolibrary.org/obo/SYMP_0000513 stridor http://purl.obolibrary.org/obo/SYMP_0000514 respiratory system and chest symptom Stridor is a respiratory system and chest symptom characterized by a harsh vibrating sound heard during respiration in cases of obstruction of the air passages. http://purl.obolibrary.org/obo/MONDO_0021193 neuroepithelial neoplasm http://purl.obolibrary.org/obo/MONDO_0021248 nervous system neoplasm A neoplasm of the nervous system that arises from the neuroepithelial tissues. Representative examples include astrocytic tumors, oligodendroglial tumors, ependymal tumors, and primitive neuroectodermal tumors. http://purl.obolibrary.org/obo/HP_0031704 Abnormal ear physiology http://purl.obolibrary.org/obo/HP_0000598 Abnormality of the ear Any functional anomaly of the ear. http://purl.obolibrary.org/obo/DOID_0080422 Dravet syndrome http://purl.obolibrary.org/obo/MONDO_0100022 neonatal/infantile epilepsy syndrome An early infantile epileptic encephalopathy that has_material_basis_in heterozygous mutation in the SCN1A gene on chromosome 2q24. http://purl.obolibrary.org/obo/HP_0025032 Abnormality of digestive system physiology http://purl.obolibrary.org/obo/HP_0025031 Abnormality of the digestive system A functional anomaly of the digestive system. http://purl.obolibrary.org/obo/NBO_0000702 atypical absence seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#generalized_non-motor_onset_seizure generalized non-motor onset seizure "An absence seizure not induced by hyperventilation." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000738 gelastic epilepsy http://purl.obolibrary.org/obo/DOID_1826 epilepsy "A type of epilepsy that is characterised a sudden burst of energy, usually in the form of laughing." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000739 dacrystic epilepsy http://purl.obolibrary.org/obo/DOID_1826 epilepsy "A type of epilepsy that is characterised a sudden paroxysmal crying." [NBO:, NBO:GVG] http://purl.obolibrary.org/obo/MP_0001340 abnormal eyelid morphology http://purl.obolibrary.org/obo/HP_0012372 Abnormal eye morphology any structural anomaly of the skin folds covering the front of the eyeball http://purl.obolibrary.org/obo/MP_0001629 abnormal heart rate http://purl.obolibrary.org/obo/MP_0004085 abnormal heartbeat greater than or fewer than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute http://purl.obolibrary.org/obo/MP_0001845 abnormal inflammatory response http://purl.obolibrary.org/obo/HP_0010978 Abnormality of immune system physiology aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues http://purl.obolibrary.org/obo/MP_0001846 increased inflammatory response http://purl.obolibrary.org/obo/MP_0001845 abnormal inflammatory response greater than expected response to injury, infection, or insult http://purl.obolibrary.org/obo/MP_0001847 brain inflammation http://purl.obolibrary.org/obo/MP_0006082 CNS inflammation local accumulation of fluid, plasma proteins, and leukocytes in the brain http://purl.obolibrary.org/obo/MP_0001956 hypopnea http://purl.obolibrary.org/obo/DOID_535 sleep disorder breathing that is shallower and/or slower than normal http://purl.obolibrary.org/obo/MP_0001993 abnormal blinking http://purl.obolibrary.org/obo/MP_0004924 abnormal behavior anomaly in the normal reflex of closing the eyes frequently and rapidly http://purl.obolibrary.org/obo/MP_0003929 decreased heart rate variability http://purl.obolibrary.org/obo/MP_0004122 abnormal sinus arrhythmia reduced variation of beat-to-beat intervals of the heart that occurs in conjunction with the respiratory cycle http://purl.obolibrary.org/obo/MP_0003953 abnormal hormone level http://purl.obolibrary.org/obo/OGMS_0000037 abnormal homeostasis aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone http://purl.obolibrary.org/obo/MP_0003965 abnormal pituitary hormone level http://purl.obolibrary.org/obo/MP_0003953 abnormal hormone level aberration in the blood or tissue concentration of any of the hormones secreted by the pituitary http://purl.obolibrary.org/obo/MP_0003967 abnormal follicle stimulating hormone level http://purl.obolibrary.org/obo/MP_0003965 abnormal pituitary hormone level anomalous concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis http://purl.obolibrary.org/obo/MP_0003969 abnormal luteinizing hormone level http://purl.obolibrary.org/obo/MP_0003965 abnormal pituitary hormone level aberrant levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary http://purl.obolibrary.org/obo/MP_0004085 abnormal heartbeat http://purl.obolibrary.org/obo/HP_0001626 Abnormality of the cardiovascular system anomaly in the appearance of regularly spaced contractions of the heart due to defects in the frequency, rate, pattern or extent of heart contraction http://purl.obolibrary.org/obo/MP_0004086 absent heartbeat http://purl.obolibrary.org/obo/MP_0004085 abnormal heartbeat lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus) http://purl.obolibrary.org/obo/MP_0004122 abnormal sinus arrhythmia http://purl.obolibrary.org/obo/MP_0001629 abnormal heart rate any anomaly in the normal phenomenon of mild acceleration and slowing of the heart rate that occurs during the respiratory cycle http://purl.obolibrary.org/obo/MP_0004144 hypotonia http://purl.obolibrary.org/obo/HP_0003808 Abnormal muscle tone decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness http://purl.obolibrary.org/obo/MP_0004874 abnormal timing of postnatal eyelid opening http://purl.obolibrary.org/obo/MP_0001340 abnormal eyelid morphology anomaly in the average time for the first postnatal eye opening, or failure of eyes to ever open http://purl.obolibrary.org/obo/MP_0004924 abnormal behavior http://purl.obolibrary.org/obo/SYMP_0019182 behavioral symptom any anomaly in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls http://purl.obolibrary.org/obo/MP_0006082 CNS inflammation http://purl.obolibrary.org/obo/MP_0001846 increased inflammatory response local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord http://purl.obolibrary.org/obo/MP_0009642 abnormal blood homeostasis http://purl.obolibrary.org/obo/OGMS_0000037 abnormal homeostasis anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood http://purl.obolibrary.org/obo/MP_0011723 ectopic neuron http://purl.obolibrary.org/obo/DOID_936 brain disease appearance of a neuron or group of neurons in a region where it is not normally found http://purl.obolibrary.org/obo/MP_0004994 abnormal brain wave pattern http://purl.obolibrary.org/obo/HP_0030178 Abnormality of central nervous system electrophysiology any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy) http://purl.obolibrary.org/obo/MP_0005176 eyelids fail to open http://purl.obolibrary.org/obo/MP_0004874 abnormal timing of postnatal eyelid opening eyes remain shut when eyelids are expected to be open http://purl.obolibrary.org/obo/MP_0005308 abnormal circulating ammonia level http://purl.obolibrary.org/obo/MP_0009642 abnormal blood homeostasis aberrant amount of ammonia or its compounds in blood, formed in the body during organic decomposition http://purl.obolibrary.org/obo/MP_0005604 hyperekplexia http://purl.obolibrary.org/obo/MONDO_0017657 rare paroxysmal movement disorder disorder characterized by pathologic startle responses, protective reactions to unanticipated, potentially threatening, stimuli of any type, particularly auditory http://purl.obolibrary.org/obo/OAE_0000002 medical intervention http://purl.obolibrary.org/obo/OBI_0000011 planned process medical intervention is a planned process that has the goal of diagnosing, preventing or relieving illness or injury. http://purl.obolibrary.org/obo/OAE_0002391 brain herniation AE http://purl.obolibrary.org/obo/OAE_0001551 brain AE a brain disorder AE that results in brain tissue, cerebrospinal fluid, and blood vessels being moved or pressed away from their usual position inside the skull. http://purl.obolibrary.org/obo/OAE_0002430 acupuncture http://purl.obolibrary.org/obo/OAE_0000002 medical intervention Acupuncture is the stimulation of specific acupuncture points along the skin of the body using thin needles. It can be associated with the application of heat, pressure, or laser light to these same points. http://purl.obolibrary.org/obo/OGMS_0000014 clinical finding http://purl.obolibrary.org/obo/OGMS_0000123 clinical data item A representation that is either the output of a clinical history taking or a physical examination or an image finding, or some combination thereof. http://purl.obolibrary.org/obo/HP_0031475 Status epilepticus without prominent motor symptoms http://purl.obolibrary.org/obo/HP_0002133 Status epilepticus There is inconclusive evidence to precisely define the duration of the seizure; however, based on current evidence an operational threshold of 10 minutes is appropriate as beyond this a seizure is likely to be more prolonged. The individual may or may not be aware or in coma. http://purl.obolibrary.org/obo/MONDO_0020072 childhood-onset epilepsy syndrome http://purl.obolibrary.org/obo/MONDO_0015650 epilepsy syndrome A epilepsy syndrome that occurs during childhood. http://purl.obolibrary.org/obo/MONDO_0020308 benign childhood occipital epilepsy, Gastaut type http://purl.obolibrary.org/obo/MONDO_0020072 childhood-onset epilepsy syndrome Benign childhood occipital epilepsy, Gastaut type is a rare, genetic neurological disorder characterized by childhood to mid-adolescence onset of frequent, brief, diurnal simple partial seizures which usually begin with visual hallucinations (e.g. phosphenes) and/or ictal blindness and may associate non visual seizures (such as deviation of the eyes, oculoclonic seizures), forced eyelid closure and blinking and sensory hallucinations. Post-ictal headache is common while impairment of consciousness is rare. http://purl.obolibrary.org/obo/MONDO_0020476 mesial temporal lobe epilepsy with hippocampal sclerosis http://purl.obolibrary.org/obo/DOID_1826 epilepsy Mesial temporal lobe epilepsy with hippocampal sclerosis is a rare epilepsy syndrome defined by seizures originating in limbic areas of the mesial temporal lobe, particularly in the hippocampus, amygdala, and in the parahippocampal gyrus and its connections, and hippocampal sclerosis, usually unilateral or assymetric. It is frequently associated with an initial precipitating event, such as febrile seizures, hypoxia, intracranial infection or head trauma, most often occurring in the first five years of life, followed by a latent period without seizures. Typical seizures consist of a characteristic aura that is frequently a rising epigastric sensation associated with emotional disturbances, illusions, and autonomic symptoms (widened pupils, palpitations), progressive impairment of consciousness, oro-alimentary automatisms (lip smacking, chewing, licking, tooth grinding), behavioral arrest, head deviation, dystonic postures, hand and verbal automatisms. Seizures are followed by postictal dysfunction. Initially, seizures are easily controlled with antiepileptic drugs, later they frequently become refractory and associated with progressive behavioral changes and memory deficits. http://purl.obolibrary.org/obo/MONDO_0043327 cerebrospinal fluid leak http://purl.obolibrary.org/obo/DOID_331 central nervous system disease Discharge of cerebrospinal fluid through a hole through the skull bone most commonly draining from the nose (CEREBROSPINAL FLUID RHINORRHEA) or the ear (CEREBROSPINAL FLUID OTORRHEA). http://purl.obolibrary.org/obo/MONDO_0043510 brain injury http://purl.obolibrary.org/obo/OGMS_0000102 injury Acute and chronic (see also brain INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and brain STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits. http://purl.obolibrary.org/obo/MONDO_0100029 antibody mediated epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#immune_etiology immune etiology An immune epilepsy where the underlying cause is antibody mediated. http://purl.obolibrary.org/obo/MONDO_0100022 neonatal/infantile epilepsy syndrome http://purl.obolibrary.org/obo/MONDO_0015650 epilepsy syndrome An epilepsy sydrome that has an onset during the neonatal or infantile stage of life. http://purl.obolibrary.org/obo/MONDO_0100020 atypical childhood epilepsy with centrotemporal spikes http://purl.obolibrary.org/obo/MONDO_0020072 childhood-onset epilepsy syndrome A childhood-onset epilepsy that is characterized by frequent seizures of multiple types, including nocturnal focal motor and fronto-parietal opercular seizures, and daytime focal motor seizures with negative myoclonus and atypical absence seizures. Centrotemporal sharp waves are seen on EEG. During the phase of the epilepsy when seizures are frequent, neuropsychological deficits and motor impairment may be present. These deficits improve when seizures remit. http://purl.obolibrary.org/obo/MONDO_0100021 photosensitive occipital lobe epilepsy http://purl.obolibrary.org/obo/MONDO_0020072 childhood-onset epilepsy syndrome A childhood-onset epilepsy that is characterized by the presence of visually-induced focal occipital lobe seizures. A proportion of patients with this syndrome have developmental delays and learning difficulty. http://purl.obolibrary.org/obo/MONDO_0100026 myoclonic encephalopathy in non-progressive disorder http://purl.obolibrary.org/obo/MONDO_0100022 neonatal/infantile epilepsy syndrome This group of epilepsies are typically is characterized by onset of seizures from day 1 of life to 5 years (peak 12 months). Both sexes are affected, however the male to female ratio is 1:2. Antecedent (including birth) history, head size, neurological and developmental findings reflect the underlying cause (if known). Myoclonic status epilepticus is often the initial presenting seizure type, however other initial seizure types may also occur. Prognosis is unfavorable with severe neurological and developmental impairments typically seen. http://purl.obolibrary.org/obo/MONDO_0100027 febrile seizures plus, genetic epilepsy with febrile seizures plus http://purl.obolibrary.org/obo/MONDO_0100022 neonatal/infantile epilepsy syndrome These epilepsy syndromes are characterized by the presence of febrile seizures in an individual that may continue past the usual age where these are expected to resolve and/or be accompanied by afebrile seizures that may be generalized seizures (tonic-clonic, atonic, myoclonic, myoclonic-atonic or absence) or focal seizures. Febrile seizures plus and genetic epilepsy with febrile seizures plus are distinguished on the basis of family history. A number of dominantly inherited genes have been linked to these syndromes, with implications for specific genetic counseling, due to the variable severity of the resulting epilepsy in different family members. http://purl.obolibrary.org/obo/MONDO_0100031 autosomal dominant epilepsy with auditory features http://purl.obolibrary.org/obo/MONDO_0100030 adolescent/adult-onset epilepsy syndrome A genetic focal epilepsy, with focal sensory auditory seizures seen in family members. Seizures often comprise such mild symptoms that they are undiagnosed. There are no implications expected for development or learning and seizures are typically infrequent and well controlled. http://purl.obolibrary.org/obo/MONDO_0100032 familial temporal lobe epilepsy syndrome http://purl.obolibrary.org/obo/MONDO_0100030 adolescent/adult-onset epilepsy syndrome This syndrome is identified in an individual who has seizures with temporal lobe features with a family history of similar seizures. Seizures often comprise such mild symptoms that they are undiagnosed. There are no implications expected for development or learning and seizures are typically infrequent and well controlled. http://purl.obolibrary.org/obo/MONDO_0100034 cerebral folate deficiency https://bio.scai.fraunhofer.de/ontology/epilepsy#metabolic_etiology metabolic etiology Cerebral folate deficiency is defined as a neurological syndrome associated with low CSF 5-methyltetrahydrofolate (5MTHF), the active folate metabolite, in the presence of normal folate metabolism outside the nervous system. Cerebral folate deficiency can result from either disturbed folate transport or from increased folate turnover within the central nervous system. http://purl.obolibrary.org/obo/PATO_0000085 sensitivity toward http://purl.obolibrary.org/obo/PATO_0001995 organismal quality A quality inhering in a bearer by virtue of the bearer's disposition to detect or perceive external stimulation. http://purl.obolibrary.org/obo/PATO_0000133 orientation http://purl.obolibrary.org/obo/PATO_0000140 position A spatial quality inhering in a bearer by virtue of the bearer's placement which is defined by the angle between the bearer and an axis, or the angle between the bearer and another object. http://purl.obolibrary.org/obo/PATO_0000140 position http://purl.obolibrary.org/obo/PATO_0001018 physical quality A spatial quality inhering in a bearer by virtue of the bearer's spatial location relative to other objects in the vicinity. http://purl.obolibrary.org/obo/PATO_0000161 rate http://purl.obolibrary.org/obo/PATO_0002062 physical quality of a process A quality of a single process inhering in a bearer by virtue of the bearer's occurrence per unit time. http://purl.obolibrary.org/obo/PATO_0000927 photosensitivity http://purl.obolibrary.org/obo/PATO_0000085 sensitivity toward A quality inhering in a bearer by virtue of the bearer's disposition to being sensitivity to the action of radiant energy. http://purl.obolibrary.org/obo/PATO_0001018 physical quality http://purl.obolibrary.org/obo/PATO_0001241 physical object quality A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities. http://purl.obolibrary.org/obo/PATO_0001236 process quality http://purl.obolibrary.org/obo/BFO_0000019 quality A quality which inheres in an process. http://purl.obolibrary.org/obo/PATO_0001241 physical object quality http://purl.obolibrary.org/obo/BFO_0000019 quality A quality which inheres in a continuant. http://purl.obolibrary.org/obo/PATO_0001912 physiological state http://purl.obolibrary.org/obo/PATO_0000161 rate A quality of a single process inhering in a bearer by virtue of the state of bearer's mechanical, physical, and biochemical processes. http://purl.obolibrary.org/obo/PATO_0001913 ictal http://purl.obolibrary.org/obo/PATO_0001912 physiological state A physiological state which is characterized by periods of high-frequency high amplitude electrical activity in neuronal tissue. http://purl.obolibrary.org/obo/PATO_0002131 abduction http://purl.obolibrary.org/obo/PATO_0002168 displaced to A displaced angular placement quality inhering in a body part by virtue of the bearer's movement away from the medial plane of the body. http://purl.obolibrary.org/obo/PATO_0002168 displaced to http://purl.obolibrary.org/obo/PATO_0000133 orientation An angular placement quality inhering in a bearer by virtue of the bearer being changed in position in relation to another entity. http://purl.obolibrary.org/obo/NBO_0000424 sleep terror http://purl.obolibrary.org/obo/NBO_0000499 NREM parasomnia "A NREM parasomnia characterised by abrupt awakening from sleep with behavior consistent with terror and a temporary inability to regain full consciousness." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000475 dyssomnia http://purl.obolibrary.org/obo/NBO_0000419 sleeping behavior phenotype "A pathological sleeping behavior related to the initiating or maintaining sleep or of excessive sleepiness and are characterized by a disturbance in the amount, quality, or timing of sleep." [wikipedia:Dyssomnia] http://purl.obolibrary.org/obo/NBO_0000494 sleep breathing disorder http://purl.obolibrary.org/obo/NBO_0000476 intrinsic sleep disorder "An intrinsic sleep disorder characterised by breathing abnormalities." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000502 somniloquy http://purl.obolibrary.org/obo/NBO_0000499 NREM parasomnia "A NREM parasomnia characterised by talking during sleep." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000504 REM parasomnia http://purl.obolibrary.org/obo/NBO_0000419 sleeping behavior phenotype "A type of parasomnia that occurs during REM sleep." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000510 sleep paralysis http://purl.obolibrary.org/obo/NBO_0000032 paralysis "A REM parasomnia characterised by periods of inability to perform voluntary movements either when going to sleep or when waking up." [wikipedia:Sleep_paralysis] http://purl.obolibrary.org/obo/NBO_0000675 reflex seizure http://purl.obolibrary.org/obo/NBO_0000686 provoked seizure "A type of seizure generated by sudden sensor stimulation caused by the environment." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000681 benign rolandic epilepsy http://purl.obolibrary.org/obo/DOID_1826 epilepsy "Benign rolandic epilepsy is characterized by either simple partial seizures involving the mouth and face or generalized tonic-clonic seizures." [wikipedia:http\://en.wikipedia.org/wiki/Rolandic_epilepsy] http://purl.obolibrary.org/obo/NBO_0000683 lateral temporal lobe epilepsy http://purl.obolibrary.org/obo/DOID_3328 temporal lobe epilepsy "A temporal lobe epilepsy arises in the neocortex on the outer surface of the temporal lobe of the brain." [wikipedia:http\://en.wikipedia.org/wiki/Temporal_lobe_epilepsy] http://purl.obolibrary.org/obo/NBO_0000687 psychogenic non-epileptic seizure http://purl.obolibrary.org/obo/NBO_0000686 provoked seizure "A type of seizure of psychological origin that superficially resembles an epileptic seizure, but without the characteristic electrical discharges associated with epilepsy." [wikipedia:http\://en.wikipedia.org/wiki/Psychogenic_non-epileptic_seizures] http://purl.obolibrary.org/obo/NBO_0000701 typical absence seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#generalized_non-motor_onset_seizure generalized non-motor onset seizure "An absence seizure induced by hyperventilation." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000705 automatism http://purl.obolibrary.org/obo/NBO_0000643 involuntary movement behavior phenotype "Purposeless repetitive motor activities that often occur during a seizure." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000707 gestural automatism http://purl.obolibrary.org/obo/NBO_0000705 automatism "An automatism characterised by involuntary movement of the limbs or body such as fumbling, picking and rubbing." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000711 drug withdrawal induced seizure http://purl.obolibrary.org/obo/NBO_0000709 drug induced seizure "A type of seizure induced by termination of drug administration." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000719 alcohol withdrawal induced seizure http://purl.obolibrary.org/obo/NBO_0000711 drug withdrawal induced seizure "A type of seizure induced by termination of alcohol administration." [NBO:GVG] http://purl.obolibrary.org/obo/UBERON_0035933 paracentral lobule http://purl.obolibrary.org/obo/UBERON_0000200 gyrus The junction of the precentral gyrus and postcentral gyrus on the medial surface of the cerebral cortex. It lies across the boundary between the frontal lobe and the parietal lobe. http://purl.obolibrary.org/obo/SYMP_0000610 dizziness http://purl.obolibrary.org/obo/SYMP_0000410 neurological and physiological symptom Dizziness is a neurological and physiological symptom characterized by a sensation of unsteadiness accompanied by a feeling of movement within the head. http://purl.obolibrary.org/obo/SYMP_0019175 sweaty http://purl.obolibrary.org/obo/SYMP_0000488 skin and integumentary tissue symptom A skin and integumentary tissue symptom characterized as the excretion of moisture in visible quantities through the opening of the sweat glands. http://purl.obolibrary.org/obo/IDOMAL_6000062 medicinal plant disposition http://purl.obolibrary.org/obo/BFO_0000016 disposition The disposition of a plant or its parts to be used to cure disease or relieve pain. http://purl.obolibrary.org/obo/SYMP_0000092 skin lesion http://purl.obolibrary.org/obo/SYMP_0000488 skin and integumentary tissue symptom Skin lesion is a skin and integumentary tissue symptom characterized as an abnormal change in structure of the skin that is especially circumscribed and well defined due to injury or disease. http://purl.obolibrary.org/obo/SYMP_0000369 ptosis http://purl.obolibrary.org/obo/SYMP_0000567 general symptom Ptosis is a general symptom characterized by a sagging or prolapse of an organ or part. http://purl.obolibrary.org/obo/SYMP_0000016 confusion http://purl.obolibrary.org/obo/SYMP_0000410 neurological and physiological symptom Confusion is a neurological and physiological symptom characterized by a disturbance of consciousness characterized by inability to engage in orderly thought or by lack of power to distinguish, choose, or act decisively. http://purl.obolibrary.org/obo/NCIT_C100018 Syncope with High Risk Cardiac Characteristics http://purl.obolibrary.org/obo/HP_0001279 Syncope A sudden loss of consciousness with loss of postural tone not related to anesthesia with high risk characteristics. High risk characteristics include non-ischemic dilated cardiomyopathy, or ischemic heart disease with significant ventricular dysfunction, hypertrophic cardiomyopathy, Brugada Syndrome, or Long QT Syndrome. (ACC) http://purl.obolibrary.org/obo/NCIT_C101035 Neonatal Injury Related to Birth http://purl.obolibrary.org/obo/OGMS_0000102 injury An injury sustained to a neonate during the birthing process. http://purl.obolibrary.org/obo/NCIT_C102122 Short Form 36 Health Survey Standard, US Version 2.0 Questionnaire http://purl.obolibrary.org/obo/NCIT_C91105 Clinical or Research Assessment Questionnaire A standardized, multipurpose, general health survey developed by John E. Ware and copyrighted by Quality Metric Inc. and the Medical Outcomes Trust in 1996 and 2000 which is used to assess the patient's functional health and overall well-being. This second version contains 36 questions that refer to the patient's symptoms or status within the past four weeks and can be completed by the patient. For each question the patient must choose from five different responses. http://purl.obolibrary.org/obo/NCIT_C15315 Rehabilitation http://purl.obolibrary.org/obo/NCIT_C15747 Supportive Care Restoration of the ability to function in a normal or near normal manner following disease, illness, or injury. http://purl.obolibrary.org/obo/NCIT_C17103 Risk Factor http://purl.obolibrary.org/obo/BFO_0000016 disposition Any aspect of an individual's life, behavior, an environmental exposure, or an inborn or inherited characteristic that increases the likelihood of a disease, condition or injury. http://purl.obolibrary.org/obo/NCIT_C20080 Angiography http://purl.obolibrary.org/obo/ERO_0001312 imaging technique The X-ray examination of the blood vessels or chambers of the heart. http://purl.obolibrary.org/obo/NCIT_C26920 Encephalopathy http://purl.obolibrary.org/obo/DOID_936 brain disease A functional and/or structural disorder of the brain caused by diseases (e.g. liver disease, kidney disease), medications, chemicals, and injuries. http://purl.obolibrary.org/obo/NCIT_C116454 Functional Connectivity Magnetic Resonance Imaging http://purl.obolibrary.org/obo/OMIT_0027689 Functional Neuroimaging A technique that monitors blood oxygen level dependent (BOLD) signals to map distant brain regions that work together while performing a task. http://purl.obolibrary.org/obo/NCIT_C116487 Diffusion Kurtosis Imaging http://purl.obolibrary.org/obo/NCIT_C64862 Diffusion Tensor Imaging An extension of conventional diffusion tension imaging, which estimates the kurtosis of the water diffusion probability distribution function. This technique is most commonly used to study the brain. http://purl.obolibrary.org/obo/NCIT_C116585 Subdural Hematoma http://purl.obolibrary.org/obo/SYMP_0000874 hematoma A collection of blood between the dura mater and the brain. http://purl.obolibrary.org/obo/NCIT_C116664 Electrocorticography http://purl.obolibrary.org/obo/ERO_0001292 physiological assay The use of electrodes placed directly on the exposed brain surface to record the electrical activity of the cerebral cortex. http://purl.obolibrary.org/obo/NCIT_C117014 Cyclical Vomiting https://bio.scai.fraunhofer.de/ontology/epilepsy#migraine_associated_disorder migraine associated disorder A condition characterized by recurrent, self-limiting episodes of vomiting associated with intense nausea, pallor, and lethargy. It is commonly a migraine precursor. http://purl.obolibrary.org/obo/NCIT_C118177 Gustatory Hallucination http://purl.obolibrary.org/obo/NBO_0000308 sensation behavior Perception of a taste in the absence of a corresponding stimulus. http://purl.obolibrary.org/obo/NCIT_C15747 Supportive Care http://purl.obolibrary.org/obo/OGMS_0000112 therapeutic procedure Supportive care is that which helps the patient and their family to cope with cancer and treatment of it from pre-diagnosis, through the process of diagnosis and treatment, to cure, continuing illness or death and into bereavement. It helps the patient to maximize the benefits of treatment and to live as well as possible with the effects of the disease. Supportive therapy may provide a patient with friendship, encouragement, practical advice such as access to community resources or how to develop a more active social life, vocational counseling, suggestions for minimizing friction with family members, and, above all, hope that the life of the patient may be improved. In all situations, supportive therapy involves the teaching of such life skills as managing medication, learning to socialize, handling finances, and getting a job. http://purl.obolibrary.org/obo/NCIT_C16033 Follow-Up http://purl.obolibrary.org/obo/OBI_0000011 planned process The process by which information about the health status of an individual is obtained after a study has officially closed; an activity that continues something that has already begun or that repeats something that has already been done. http://purl.obolibrary.org/obo/NCIT_C64862 Diffusion Tensor Imaging http://purl.obolibrary.org/obo/ERO_0001235 magnetic resonance imaging A type of diffusion-weighted magnetic resonance imaging (DW-MRI) that maps the diffusion of water in three dimensions, the principal purpose of which is to image the white matter of the brain, specifically measuring the anisotropy, location, and orientation of the neural tracts, which can demonstrate microstructural changes or differences with neuropathology and treatment. http://purl.obolibrary.org/obo/NCIT_C81328 Body Weight http://purl.obolibrary.org/obo/NCIT_C19332 Personal Attribute The weight of a subject. http://purl.obolibrary.org/obo/NCIT_C61377 Network http://purl.obolibrary.org/obo/BFO_0000031 generically dependent continuant An interconnected system of things or people. http://purl.obolibrary.org/obo/MONDO_0000456 cerebral creatine deficiency syndrome https://bio.scai.fraunhofer.de/ontology/epilepsy#metabolic_etiology metabolic etiology Creatine deficiency syndrome (CDS) comprises a group of inborn errors of creatine metabolism, characterized by a global developmental delay, intellectual disability and associated neurological (seizures, movement disorders, myopathy) and behavioral manifestions. CDS includes two creatine biosynthesis disorders; guanidinoacetate methyltransferase deficiency and L- Arginine: glycine amidinotransferase deficiency, as well as X-linked creatine transporter deficiency. http://purl.obolibrary.org/obo/MONDO_0000839 congenital abnormality http://purl.obolibrary.org/obo/DOID_4 disease Any abnormality, anatomical or biochemical, evident at birth or during the neonatal period. http://purl.obolibrary.org/obo/MONDO_0002025 psychiatric disorder http://purl.obolibrary.org/obo/DOID_150 disease of mental health A disorder characterized by behavioral and/or psychological abnormalities, often accompanied by physical symptoms. The symptoms may cause clinically significant distress or impairment in social and occupational areas of functioning. Representative examples include anxiety disorders, cognitive disorders, mood disorders and schizophrenia. http://purl.obolibrary.org/obo/MONDO_0003083 venous hemangioma http://purl.obolibrary.org/obo/DOID_1287 cardiovascular system disease A rare slow growing benign tumor of aberrant and ectatic venous connections. http://purl.obolibrary.org/obo/MONDO_0003155 cavernous hemangioma http://purl.obolibrary.org/obo/DOID_1287 cardiovascular system disease A hemangioma characterized by the presence of cavernous vascular spaces. http://purl.obolibrary.org/obo/MONDO_0005070 neoplasm (disease) http://purl.obolibrary.org/obo/MONDO_0023370 neoplastic disease or syndrome A benign or malignant tissue growth resulting from uncontrolled cell proliferation. Benign neoplastic cells resemble normal cells without exhibiting significant cytologic atypia, while malignant cells exhibit overt signs such as dysplastic features, atypical mitotic figures, necrosis, nuclear pleomorphism, and anaplasia. Representative examples of benign neoplasms include papillomas, cystadenomas, and lipomas; malignant neoplasms include carcinomas, sarcomas, lymphomas, and leukemias. http://purl.obolibrary.org/obo/MONDO_0005084 mental disorder http://purl.obolibrary.org/obo/MONDO_0002025 psychiatric disorder A disease that has its basis in the disruption of mental process. http://purl.obolibrary.org/obo/MONDO_0005132 cytomegalovirus infection https://bio.scai.fraunhofer.de/ontology/epilepsy#infectious_etiology infectious etiology A herpesvirus infection caused by Cytomegalovirus. Healthy individuals generally do not produce symptoms. However, the infection may be life-threatening in affected immunocompromised patients. The virus may cause retinitis, esophagitis, gastritis, and colitis. Morphologically, it is characterized by the presence of intranuclear inclusion bodies. http://purl.obolibrary.org/obo/MONDO_0005156 encephalomyelitis http://purl.obolibrary.org/obo/DOID_331 central nervous system disease Inflammation of the brain and the spinal cord. http://purl.obolibrary.org/obo/MONDO_0005287 developmental disability http://purl.obolibrary.org/obo/DOID_0060037 developmental disorder of mental health Disorders in which there is a delay in development based on that expected for a given age level or stage of development. These impairments or disabilities originate before age 18, may be expected to continue indefinitely, and constitute a substantial impairment. Biological and nonbiological factors are involved in these disorders. (From American Psychiatric Glossary, 6th ed) http://purl.obolibrary.org/obo/MONDO_0005384 partial epilepsy http://purl.obolibrary.org/obo/DOID_1826 epilepsy A seizure caused by a localized disorder. http://purl.obolibrary.org/obo/MONDO_0005567 substance withdrawal syndrome http://purl.obolibrary.org/obo/DOID_303 substance-related disorder A substance-specific organic brain syndrome that follows the discontinuation of administration or use, or reduction in intake of an addictive substance, e.g. opioids, barbiturates and alcohol; amphetamines or similarly acting sympathomimetics; cocaine; nicotine; sedatives, hypnotics, or anxiolytics. Syndrome manifests with diverse, often painful physical and psychological symptoms, which include but not limited to intense drug craving, anxiety, depression, insomnia, nausea, perspiration, body aches, tremors, hallucinations, and convulsions. http://purl.obolibrary.org/obo/MONDO_0005697 cerebral toxoplasmosis https://bio.scai.fraunhofer.de/ontology/epilepsy#infectious_etiology infectious etiology Infections of the brain caused by the protozoan toxoplasma gondii that primarily arise in individuals with immunologic deficiency syndromes (see also aids-related opportunistic infections). The infection may involve the brain diffusely or form discrete abscesses. Clinical manifestations include seizures, altered mentation, headache, focal neurologic deficits, and intracranial hypertension. (From Joynt, Clinical Neurology, 1998, Ch27, pp41-3) http://purl.obolibrary.org/obo/MONDO_0007365 seizures, benign familial neonatal, 1 http://purl.obolibrary.org/obo/MONDO_0016027 benign neonatal seizures Any benign neonatal seizures in which the cause of the disease is a mutation in the KCNQ2 gene. http://purl.obolibrary.org/obo/MONDO_0008206 benign paroxysmal tonic upgaze of childhood with ataxia http://purl.obolibrary.org/obo/MONDO_0017657 rare paroxysmal movement disorder Benign paroxysmal tonic upgaze of childhood with ataxia is a rare paroxysmal movement disorder characterized by episodes of sustained, conjugate, upward deviation of the eyes and down beating saccades in attempted downgaze (with preserved horizontal eye movements) which is accompanied by ataxic symptomatology (unsteady gait, lack of balance and movement coordination disturbances) in an otherwise healthy individual. Bilateral vertical nystagmus is associated. Symptoms generally disappear spontaneously within 1-2 years after onset. http://purl.obolibrary.org/obo/MONDO_0009187 celiac disease-epilepsy-cerebral calcification syndrome http://purl.obolibrary.org/obo/MONDO_0100029 antibody mediated epilepsy Celiac disease, epilepsy and cerebral calcification syndrome (CEC) is a rare disorder characterized by the combination of auto-immune intestinal disease, epileptic seizures and cerebral calcifications. http://purl.obolibrary.org/obo/MONDO_0009945 pyridoxine-dependent epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#metabolic_etiology metabolic etiology Pyridoxine-dependent epilepsy (PDE) is a rare neurometabolic disease characterized by recurrent intractable seizures in the prenatal, neonatal and postnatal period that are resistant to anti-epileptic drugs (AEDs) but that are responsive to pharmacological dosages of pyridoxine (vitamin B6). http://purl.obolibrary.org/obo/MONDO_0011146 tetrasomy 12p http://purl.obolibrary.org/obo/MONDO_0019040 chromosomal anomaly Pallister-Killian syndrome (PKS) is a rare multiple congenital anomaly/intellectual deficit syndrome caused by mosaic tissue-limited tetrasomy for chromosome 12p. http://purl.obolibrary.org/obo/MONDO_0013792 intracerebral hemorrhage http://purl.obolibrary.org/obo/HP_0001342 Cerebral hemorrhage Bleeding into one or both cerebral hemispheres including the basal ganglia and the cerebral cortex. It is often associated with hypertension and craniocerebral trauma. http://purl.obolibrary.org/obo/MONDO_0014708 ring chromosome 14 http://purl.obolibrary.org/obo/MONDO_0019040 chromosomal anomaly Ring chromosome 14 syndrome is characterized by intellectual deficit, retinal and skin pigmentation disorders, seizures, and dysmorphic features, including flat occiput, epicanthal folds, downward slanting eyes, flat nasal bridge, upturned nostrils, short neck, and large low set ears. http://purl.obolibrary.org/obo/MONDO_0015247 opsoclonus-myoclonus syndrome http://purl.obolibrary.org/obo/MONDO_0017657 rare paroxysmal movement disorder Opsoclonus myoclonus syndrome (OMS) is a rare neuroinflammatory disease of paraneoplastic, parainfectious or idiopathic origin, characterized by opsoclonus, myoclonus, ataxia, and behavioral and sleep disorders. http://purl.obolibrary.org/obo/MONDO_0015436 ring chromosome 20 http://purl.obolibrary.org/obo/MONDO_0019040 chromosomal anomaly Ring chromosome 20 syndrome is marked by a characteristic seizure phenotype. Depending on the amount of chromosomal loss and associated mosaicism, ring(20) can be associated with macrocephaly, mild to moderate intellectual deficit, or behavioural problems. In rare cases, brain, kidney or heart malformations may be present. http://purl.obolibrary.org/obo/MONDO_0015584 febrile infection-related epilepsy syndrome https://bio.scai.fraunhofer.de/ontology/epilepsy#unknown_etiology unknown etiology Febrile infection-related epilepsy syndrome (FIRES) describes an explosive-onset, potentially fatal acute epileptic encephalopathy that develops in previously healthy children and adolescents following the onset of a non-specific febrile illness. http://purl.obolibrary.org/obo/MONDO_0015723 trisomy 12p http://purl.obolibrary.org/obo/MONDO_0019040 chromosomal anomaly Trisomy 12p is an extremely rare chromosomal disorder (over 30 cases reported worldwide) characterized by craniofacial malformations (round face, prominent cheeks, high bulging forehead, broad and flat nasal bridge, short nose with anteverted nostrils, long philtrum, prominent and everted lower lip, low-set ears, abnormally folded helix, protuberant antihelix), postnatal growth retardation, mental and psychomotor retardation, generalized hypotonia, abnormally short wide hands and/or other abnormalities. http://purl.obolibrary.org/obo/MONDO_0015917 malignant glioma http://purl.obolibrary.org/obo/MONDO_0021042 glioma A grade III or grade IV glioma arising from the central nervous system. This category includes glioblastoma, anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligodendroglioma, and anaplastic oligoastrocytoma. http://purl.obolibrary.org/obo/MONDO_0016027 benign neonatal seizures http://purl.obolibrary.org/obo/MONDO_0020070 neonatal epilepsy syndrome Benign familial neonatal epilepsy (BFNE) is a rare genetic epilepsy syndrome characterized by the occurrence of afebrile seizures in otherwise healthy newborns with onset in the first few days of life. http://purl.obolibrary.org/obo/MONDO_0016158 narcolepsy-cataplexy syndrome http://purl.obolibrary.org/obo/DOID_535 sleep disorder Narcolepsy with cataplexy is a sleep disorder characterized by excessive day-time sleepiness associated with uncontrollable sleep urges and cataplexy (loss of muscle tone often triggered by pleasant emotions). http://purl.obolibrary.org/obo/MONDO_0016608 megalencephaly (disease) http://purl.obolibrary.org/obo/DOID_936 brain disease A congenital abnormality in which the occipitofrontal circumference is greater than two standard deviations above the mean for a given age. It is associated with hydrocephalus; subdural effusion; arachnoid cysts; or is part of a genetic condition (e.g., alexander disease; sotos syndrome). http://purl.obolibrary.org/obo/MONDO_0016688 fibrillary astrocytoma http://purl.obolibrary.org/obo/MONDO_0016686 diffuse astrocytoma The most frequent histological variant of diffuse astrocytoma. It is predominantly composed of fibrillary neoplastic astrocytes. Nuclear atypia is a diagnostic criterion but mitotic activity, necrosis and microvascular proliferation are absent. The occasional or regional occurrence of gemistocytic neoplastic cells is compatible with the diagnosis of fibrillary astrocytoma. (WHO) http://purl.obolibrary.org/obo/MONDO_0016702 oligoastrocytoma http://purl.obolibrary.org/obo/MONDO_0021639 grade II glioma A WHO grade II tumor composed of a conspicuous mixture of two distinct neoplastic cell types morphologically resembling the tumor cells in oligodendroglioma and diffuse astrocytoma. (WHO) http://purl.obolibrary.org/obo/MONDO_0018027 duplication/inversion 15q11 http://purl.obolibrary.org/obo/MONDO_0019040 chromosomal anomaly Isodicentric chromosome 15 syndrome is a chromosome abnormality that affects many different parts of the body. As the name suggests, people with this condition have an extra chromosome (called an isodicentric chromosome 15 ) which is made of two pieces of chromosome 15 that are stuck together end-to-end. Although the severity of the condition and the associated features vary from person to person, common signs and symptoms include poor muscle tone in newborns; developmental delay; mild to severe intellectual disability; delayed or absent speech; behavioral abnormalities; and seizures . Most cases of isodicentric chromosome 15 syndrome occur sporadically in people with no family history of the condition. Treatment is based on the signs and symptoms present in each person. http://purl.obolibrary.org/obo/MONDO_0018214 generalized epilepsy with febrile seizures plus http://purl.obolibrary.org/obo/DOID_1826 epilepsy Generalized epilepsy with febrile seizures plus (GEFS+) is a familial epilepsy syndrome in which family members display a seizure disorder from the GEFS+ spectrum which ranges from simple febrile seizures (FS) to the more severe phenotype of myoclonic-astatic epilepsy (MAE) or Dravet syndrome (DS) (see these terms). http://purl.obolibrary.org/obo/MONDO_0019052 inborn errors of metabolism http://purl.obolibrary.org/obo/DOID_0014667 disease of metabolism A group of disorders present at birth that involve genetic defects leading to disturbances in carbohydrate, lipid, lysosomal storage or amino acid metabolism in the body. The inborn errors of metabolism are typically rare, but this class also encompasses non-rare diseases like hereditary hemochromatosis type 1 http://purl.obolibrary.org/obo/MONDO_0019104 Sandifer syndrome http://purl.obolibrary.org/obo/NCIT_C69023 Miscellaneous Sandifer syndrome is a paroxysmal dystonic movement disorder occurring in association with gastro-oesophageal reflux, and, in some cases, hiatal hernia. http://purl.obolibrary.org/obo/MONDO_0020067 infectious encephalitis http://purl.obolibrary.org/obo/DOID_9588 encephalitis An acute infectious process that affects the brain tissue. It is usually caused by viruses and less often by bacteria, parasites, and fungi. http://purl.obolibrary.org/obo/MONDO_0020310 familial focal epilepsy with variable foci http://purl.obolibrary.org/obo/MONDO_0100036 variable age onset epilepsy Familial focal epilepsy with variable foci is a rare genetic epilepsy disorder characterized by autosomal dominant lesional and nonlesional focal epilepsy with variable penetrance. Focal seizures emanate from different cortical locations (temporal, frontal, centroparietal, parietal, parietaloccipital, occipital) in different family members, but for each individual a single focus remains constant throughout lifetime. Seizure type (tonic, tonic-clonic or hyperkinetic) and severity varies among family members and tends to decrease (but do not disappear) during adulthood. Many patients have an aura and show automatisms during diurnal seizures whereas others have nocturnal seizures. Most individuals are of normal intelligence but patients with intellectual disability, autistic spectrum disorder and obsessive-compulsive disorder have been described. http://purl.obolibrary.org/obo/MONDO_0021042 glioma http://purl.obolibrary.org/obo/MONDO_0021193 neuroepithelial neoplasm A benign or malignant brain and spinal cord tumor that arises from glial cells (astrocytes, oligodendrocytes, ependymal cells). Tumors that arise from astrocytes are called astrocytic tumors or astrocytomas. Tumors that arise from oligodendrocytes are called oligodendroglial tumors. Tumors that arise from ependymal cells are called ependymomas. http://purl.obolibrary.org/obo/MONDO_0019040 chromosomal anomaly https://bio.scai.fraunhofer.de/ontology/epilepsy#genetic_etiology genetic etiology Clinical conditions caused by an abnormal chromosome constitution in which there is extra or missing chromosome material (either a whole chromosome or a chromosome segment). (from Thompson et al., Genetics in Medicine, 5th ed, p429) http://purl.obolibrary.org/obo/MONDO_0016686 diffuse astrocytoma http://purl.obolibrary.org/obo/MONDO_0016685 low-grade astrocytoma A low-grade (WHO grade II) astrocytic neoplasm. It is characterized by diffuse infiltration of neighboring central nervous system structures. These lesions typically affect young adults and have a tendency for progression to anaplastic astrocytoma and glioblastoma. Based on the IDH genes mutation status, diffuse astrocytomas are classified as IDH-mutant, IDH-wildtype, and not otherwise specified. http://purl.obolibrary.org/obo/MONDO_0016705 angiocentric glioma http://purl.obolibrary.org/obo/MONDO_0021637 low grade glioma Angiocentric glioma (AG) is an extremely rare slow-growing glial neoplasm of the central nervous system, usually arising in a superficial location in the cerebrum, affecting all ages and both sexes, and characterized by intractable seizures and headaches, with most cases being cured by surgical incision alone and therefore having a good prognosis. http://purl.obolibrary.org/obo/MONDO_0017201 Spasmus nutans (disease) http://purl.obolibrary.org/obo/NCIT_C69023 Miscellaneous Spasmus nutans (SN) is a rare eye disease characterized by the clinical triad of asymmetric and pendular nystagmus, head nodding, and torticollis. http://purl.obolibrary.org/obo/MONDO_0017409 fetal cytomegalovirus syndrome http://purl.obolibrary.org/obo/MONDO_0005132 cytomegalovirus infection An infection with the Cytomegalovirus that is present from birth. http://purl.obolibrary.org/obo/MONDO_0018199 new-onset refractory status epilepticus http://purl.obolibrary.org/obo/MONDO_0018200 acute encephalopathy with inflammation-mediated status epilepticus New-onset refractory status epilepticus is an acute encephalopathy with inflammation-mediated status epilepticus characterized by an acute refractory status epilepticus, typically of the tonic-clonic type, following prodromal symptoms of confusion, fever, fatigue, headache, symptoms of gastrointestinal or upper respiratory tract infection, behavioral changes or hallucinations. Brain MRI abnormalities and abnormal findings in CSF, including pleocytosis and/or elevated protein levels, are frequently found during acute episode. Treatment-resistant epilepsy, cognitive and psychiatric impairments are usual consequences. http://purl.obolibrary.org/obo/MONDO_0019113 benign paroxysmal torticollis of infancy https://bio.scai.fraunhofer.de/ontology/epilepsy#migraine_associated_disorder migraine associated disorder Benign paroxysmal torticollis of infancy (BPTI) is a rare functional disorder characterised by recurrent episodes of torticollic posturing of the head (inclination or tilting of the head to one side) in healthy children. http://purl.obolibrary.org/obo/MONDO_0019137 non-24-hour sleep-wake syndrome http://purl.obolibrary.org/obo/MONDO_0024361 circadian rhythm sleep disorder Non-24-hour sleep-wake disorder (non-24 disorder), also known as hypernychthemeral syndrome, is a circadian rhythm sleep disorder characterized by non-synchronization to a 24-hour day leading to insomnia and daytime sleepiness with sometimes severe associated manifestations. http://purl.obolibrary.org/obo/MONDO_0019197 folinic acid-responsive seizures https://bio.scai.fraunhofer.de/ontology/epilepsy#metabolic_etiology metabolic etiology Folinic acid-responsive seizures is a very rare neonatal epileptic encephalopathy disorder characterized clinically by myoclonic and clonic, or clonic seizures associated with apnea occurring several hours to 5 days after birth and responding to folinic acid. http://purl.obolibrary.org/obo/OGMS_0000108 health care process assay http://purl.obolibrary.org/obo/OGMS_0000096 health care process A health care process with the objective to produce information about the material entity that is the evaluant, by physically examining it or its proxies. http://purl.obolibrary.org/obo/MONDO_0023370 neoplastic disease or syndrome http://purl.obolibrary.org/obo/DOID_14566 disease of cellular proliferation Either an isolated neoplasm or a syndrome with neoplasm as a major feature. http://purl.obolibrary.org/obo/NCIT_C161601 Surgical Procedure by Type http://purl.obolibrary.org/obo/OMIABIS_0001041 surgical procedure A categorization of surgical procedures by type or purpose. http://purl.obolibrary.org/obo/NCIT_C160587 Executive Function Disorder http://purl.obolibrary.org/obo/DOID_1561 cognitive disorder Cognitive, emotional, and behavioral difficulties that often occur in conjunction with frontal lobe disorders, including traumatic injury and dementia. It is also a feature of attention deficit disorder and other non-trauma-induced conditions. http://purl.obolibrary.org/obo/DOID_0111537 paroxysmal extreme pain disorder http://purl.obolibrary.org/obo/NCIT_C69023 Miscellaneous An autonomic nervous system disease characterized by onset in the neonatal period or infancy of paroxysms of rectal, ocular, or submandibular pain with flushing that has_material_basis_in heterozygous mutation in SCN9A on chromosome 2q24.3. http://purl.obolibrary.org/obo/DOID_0111563 Sturge-Weber syndrome http://purl.obolibrary.org/obo/MONDO_0024291 vascular malformation A vascular disease characterized by intracranial vascular anomaly, leptomeningeal angiomatosis, facial cutaneous vascular malformations, and glaucoma that has_material_basis_in somatic mutation in GNAQ on chromosome 9q21.2. http://purl.obolibrary.org/obo/DOID_1768 conversion disorder http://purl.obolibrary.org/obo/DOID_4737 somatoform disorder A somatoform disorder that involves numbness, blindness, paralysis or fits without a neurological cause. http://purl.obolibrary.org/obo/DOID_1825 childhood absence epilepsy http://purl.obolibrary.org/obo/DOID_1827 idiopathic generalized epilepsy A childhood electroclinical syndrome that is characterized by brief and frequent absence seizures in children with age of onset between four and ten years. http://purl.obolibrary.org/obo/DOID_1926 Gaucher's disease http://purl.obolibrary.org/obo/DOID_1927 sphingolipidosis A sphingolipidosis characterized by deficiency of the enzyme glucocerebrosidase which results in the accumulation of harmful quantities of the glycolipid glucocerebroside throughout the body, especially within the bone marrow, spleen and liver. http://purl.obolibrary.org/obo/DOID_1932 Angelman syndrome http://purl.obolibrary.org/obo/MONDO_0019040 chromosomal anomaly A syndrome that is characterized by delayed development, intellectual disability, severe speech impairment, and problems with movement and balance. http://purl.obolibrary.org/obo/DOID_2316 brain ischemia http://purl.obolibrary.org/obo/DOID_6713 cerebrovascular disease An ischemia that is characterized by insufficient blood flow to the brain to meet metabolic demand. http://purl.obolibrary.org/obo/DOID_2426 gangliocytoma http://purl.obolibrary.org/obo/DOID_0060090 central nervous system benign neoplasm A central nervous system benign neoplasm that has_material_basis_in mature neurons, and is classified by the absence of neoplastic glial cells. http://purl.obolibrary.org/obo/DOID_2548 reflex epilepsy http://purl.obolibrary.org/obo/MONDO_0100036 variable age onset epilepsy A variable age at onset electroclinical syndrome that is consistently induced by identifiable and objective-specific triggers, which may be an afferent stimulus or by the patient's own activity. http://purl.obolibrary.org/obo/DOID_2846 bruxism http://purl.obolibrary.org/obo/SYMP_0000566 sleep disturbance A sleep disorder that involves involuntarily grinding or clenching of the teeth while sleeping. http://purl.obolibrary.org/obo/DOID_3069 astrocytoma http://purl.obolibrary.org/obo/MONDO_0015917 malignant glioma A malignant glioma that is has_material_basis_in astrocyte cells, a type of star-shaped glial cell, located in the brain and spinal cord. http://purl.obolibrary.org/obo/DOID_3118 hepatobiliary disease http://purl.obolibrary.org/obo/DOID_77 gastrointestinal system disease A gastrointestinal system disease that is located_in the liver and/or biliary tract. http://purl.obolibrary.org/obo/DOID_3454 brain infarction http://purl.obolibrary.org/obo/DOID_6713 cerebrovascular disease A cerebrovascular disease that is characterized by tissue necrosis located_in the brain, resulting from inadequate blood flow through the brain. http://purl.obolibrary.org/obo/DOID_3488 cellulitis http://purl.obolibrary.org/obo/DOID_65 connective tissue disease A skin disease where there is a diffuse infection of connective tissue with severe inflammation of dermal and subcutaneous layers of the skin. Cellulitis can be caused by normal skin flora or by exogenous bacteria, and often occurs where the skin has previously been broken: cracks in the skin, cuts, blisters, burns, insect bites, surgical wounds, or sites of intravenous catheter insertion. http://purl.obolibrary.org/obo/DOID_3526 cerebral infarction http://purl.obolibrary.org/obo/DOID_3454 brain infarction A cerebrovascular disease that is characterized by an area of necrotic tissue in the brain resulting from a blockage or narrowing in the arteries supplying blood and oxygen to the brain. http://purl.obolibrary.org/obo/DOID_3687 MELAS syndrome http://purl.obolibrary.org/obo/MONDO_0044970 mitochondrial disease A mitochondrial encephalomyopathy that is characterized by mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes, has_symptom myalgia, motor weakness, headaches, seizures, and stroke-like episodes with acute hemiparesis and severe headaches, and develops_from mutation in mitochondrial genes including MT-TL1, which encodes tRNA proteins. http://purl.obolibrary.org/obo/DOID_374 nutrition disease http://purl.obolibrary.org/obo/DOID_0060158 acquired metabolic disease An acquired metabolic disease that is characterized by an insufficient intake of food or of certain nutrients, by an inability of the body to absorb and use nutrients, or by overconsumption of certain foods. http://purl.obolibrary.org/obo/DOID_4428 dyslexia http://purl.obolibrary.org/obo/DOID_13365 reading disorder A reading disorder resulting from a developmental reading disability involving the inability to process graphic symbols resulting in impairment of reading ability. http://purl.obolibrary.org/obo/DOID_4540 dysgraphia http://purl.obolibrary.org/obo/DOID_0060047 writing disorder A writing disorder that involves a deficiency in the ability to write where the writing is distorted or incorrect, spelling difficulty, poor handwriting or trouble putting thoughts on paper. http://purl.obolibrary.org/obo/DOID_4543 retrograde amnesia http://purl.obolibrary.org/obo/DOID_10914 amnestic disorder An amnestic disorder that involves a loss of one's pre-existing memories to conscious recollection. http://purl.obolibrary.org/obo/DOID_4724 brain edema http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is characterized by excess accumulation of fluid in the intracellular and/or extracellular spaces of the brain, has_symptom nausea, has_symptom vomiting, has_symptom blurred vision, has_symptom seizure, has_symptom coma. http://purl.obolibrary.org/obo/DOID_4851 pilocytic astrocytoma http://purl.obolibrary.org/obo/MONDO_0015917 malignant glioma An astrocytoma that is characterized by cells that look like fibers when viewed under a microscope and is located_in the brain. http://purl.obolibrary.org/obo/DOID_4890 juvenile myoclonic epilepsy http://purl.obolibrary.org/obo/MONDO_0100030 adolescent/adult-onset epilepsy syndrome A adolescence-adult electroclinical syndrome that is characterized by brief, involuntary twitching of a muscle or a group of muscles (myoclonus) early in the morning with onset between 12 and 18 years. http://purl.obolibrary.org/obo/DOID_5078 ganglioglioma http://purl.obolibrary.org/obo/HP_0002664 Neoplasm A cell type benign neoplasm that has_material_basis_in glial-type cells. http://purl.obolibrary.org/obo/DOID_526 human immunodeficiency virus infectious disease https://bio.scai.fraunhofer.de/ontology/epilepsy#infectious_etiology infectious etiology A viral infectious disease that results in destruction of immune system, leading to life-threatening opportunistic infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. The virus infects helper T cells (CD4+ T cells) which are directly or indirectly destroyed, macrophages, and dendritic cells. The infection has symptom diarrhea, has symptom fatigue, has symptom fever, has symptom vaginal yeast infection, has symptom headache, has symptom mouth sores, has symptom muscle aches, has symptom sore throat, and has symptom swollen lymph glands. http://purl.obolibrary.org/obo/DOID_5340 anterograde amnesia http://purl.obolibrary.org/obo/DOID_10914 amnestic disorder An amnestic disorder that involves the impaired or lost ability to memorize new things. http://purl.obolibrary.org/obo/DOID_5844 myocardial infarction http://purl.obolibrary.org/obo/DOID_3393 coronary artery disease A coronary artery disease characterized by myocardial cell death (myocardial necrosis) due to prolonged ischaemia. http://purl.obolibrary.org/obo/DOID_593 agoraphobia http://purl.obolibrary.org/obo/DOID_591 phobic disorder A phobic disorder involving the specific anxiety about being in a place or situation where escape is difficult or embarrassing or where help may be unavailable. http://purl.obolibrary.org/obo/DOID_594 panic disorder http://purl.obolibrary.org/obo/DOID_2030 anxiety disorder An anxiety disorder that is characterized by unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress. http://purl.obolibrary.org/obo/DOID_635 acquired immunodeficiency syndrome http://purl.obolibrary.org/obo/DOID_526 human immunodeficiency virus infectious disease A Human immunodeficiency virus infectious disease that results_in reduction in the numbers of CD4-bearing helper T cells below 200 per ��L of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has_material_basis_in Human immunodeficiency virus 1 or has_material_basis_in Human immunodeficiency virus 2, which are transmitted_by sexual contact, transmitted_by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted_by congenital method, and transmitted_by contaminated needles. Opportunistic infections are common in people with AIDS. http://purl.obolibrary.org/obo/DOID_6621 cerebral angioma http://purl.obolibrary.org/obo/MONDO_0024291 vascular malformation A brain angioma that is characterized by vascular abnormalities that develops from cranial and spinal blood vasculature, has_material_basis_in abnormally proliferating cells, derives_from endothelial cells in and about the vascular lumen. http://purl.obolibrary.org/obo/DOID_7148 rheumatoid arthritis http://purl.obolibrary.org/obo/DOID_848 arthritis An arthritis that is an autoimmune disease which attacks healthy cells and tissue located_in joint. http://purl.obolibrary.org/obo/DOID_7725 epilepsy with generalized tonic-clonic seizures http://purl.obolibrary.org/obo/MONDO_0100030 adolescent/adult-onset epilepsy syndrome An adolescence-adult electroclinical syndrome starting in adolescence exhibiting generalized tonic-clonic seizures as the only seizure type. http://purl.obolibrary.org/obo/DOID_8461 Aicardi syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A syndrome that is characterized by absence or underdeveloped tissue connecting the left and right halves of the brain, infantile spasms and chorioretinal lacunae, which are defects in the light-sensitive tissue at the back of the eye. http://purl.obolibrary.org/obo/DOID_8506 bullous pemphigoid http://purl.obolibrary.org/obo/DOID_0060039 autoimmune disease of skin and connective tissue An autoimmune disease of skin and connective tissue characterized by large blisters. http://purl.obolibrary.org/obo/DOID_8869 neuromyelitis optica http://purl.obolibrary.org/obo/DOID_319 spinal cord disease A central nervous system disease characterized by inflammation of the optic nerve (optic neuritis) and inflammation of the spinal cord (myelitis). http://purl.obolibrary.org/obo/DOID_8893 psoriasis http://purl.obolibrary.org/obo/DOID_37 skin disease A skin disease that is characterized by patches of thick red skin and silvery scales. http://purl.obolibrary.org/obo/DOID_891 progressive myoclonus epilepsy http://purl.obolibrary.org/obo/MONDO_0100036 variable age onset epilepsy A variable age at onset electroclinical syndrome characterised by a relentlessly progressive disease course until death. http://purl.obolibrary.org/obo/DOID_8970 subacute sclerosing panencephalitis http://purl.obolibrary.org/obo/DOID_934 viral infectious disease A viral infectious disease that results_in infection located_in brain and that has_material_basis_in Measles virus which is immune resistant. http://purl.obolibrary.org/obo/DOID_8986 narcolepsy http://purl.obolibrary.org/obo/NBO_0000419 sleeping behavior phenotype A sleep disorder that involves an excessive urge to sleep at inappropriate times, such as while at work. http://purl.obolibrary.org/obo/DOID_9074 systemic lupus erythematosus http://purl.obolibrary.org/obo/DOID_8857 lupus erythematosus A lupus erythematosus that is an inflammation of connective tissue marked by skin rashes, joint pain and swelling, inflammation of the kidneys and inflammation of the tissue surrounding the heart. http://purl.obolibrary.org/obo/DOID_9091 REM sleep behavior disorder http://purl.obolibrary.org/obo/DOID_535 sleep disorder A sleep disorder that involves abnormal behavior including the acting out of violent or dramatic dreams during the sleep phase with rapid eye movement. http://purl.obolibrary.org/obo/DOID_92 speech disorder http://purl.obolibrary.org/obo/DOID_2033 communication disorder A communication disorder that involves difficulty with the act of speech production. http://purl.obolibrary.org/obo/DOID_9207 periodic limb movement disorder http://purl.obolibrary.org/obo/DOID_535 sleep disorder A sleep disorder that involves involuntary limb movement during sleep. http://purl.obolibrary.org/obo/DOID_9281 phenylketonuria http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder An amino acid metabolic disorder that is characterized by a mutation in the gene for the hepatic enzyme phenylalanine hydroxylase (PAH), rendering it nonfunctional. http://purl.obolibrary.org/obo/DOID_9993 hypoglycemia http://purl.obolibrary.org/obo/DOID_4194 glucose metabolism disease A glucose metabolism disease that is characterized by abnormally low levels of blood glucose. http://purl.obolibrary.org/obo/HP_0000009 Functional abnormality of the bladder http://purl.obolibrary.org/obo/HP_0000014 Abnormality of the bladder Dysfunction of the urinary bladder. http://purl.obolibrary.org/obo/HP_0000014 Abnormality of the bladder http://purl.obolibrary.org/obo/HP_0010936 Abnormality of the lower urinary tract An abnormality of the urinary bladder. http://purl.obolibrary.org/obo/HP_0000079 Abnormality of the urinary system http://purl.obolibrary.org/obo/HP_0000119 Abnormality of the genitourinary system An abnormality of the urinary system. http://purl.obolibrary.org/obo/HP_0000118 Phenotypic abnormality http://purl.obolibrary.org/obo/BFO_0000019 quality A phenotypic abnormality. http://purl.obolibrary.org/obo/HP_0000119 Abnormality of the genitourinary system http://purl.obolibrary.org/obo/HP_0000118 Phenotypic abnormality The presence of any abnormality of the genitourinary system. http://purl.obolibrary.org/obo/HP_0000152 Abnormality of head or neck http://purl.obolibrary.org/obo/HP_0000118 Phenotypic abnormality An abnormality of head and neck. http://purl.obolibrary.org/obo/HP_0000153 Abnormality of the mouth http://purl.obolibrary.org/obo/HP_0000271 Abnormality of the face An abnormality of the mouth. http://purl.obolibrary.org/obo/HP_0000234 Abnormality of the head http://purl.obolibrary.org/obo/HP_0000152 Abnormality of head or neck An abnormality of the head. http://purl.obolibrary.org/obo/HP_0000301 Abnormality of facial musculature http://purl.obolibrary.org/obo/HP_0011805 Abnormal skeletal muscle morphology An anomaly of a muscle that is innervated by the facial nerve (the seventh cranial nerve). http://purl.obolibrary.org/obo/HP_0000317 Facial myokymia http://purl.obolibrary.org/obo/HP_0002411 Myokymia Facial myokymia is a fine fibrillary activity of one or more muscles innervated by the facial nerve (the seventh cranial nerve). http://purl.obolibrary.org/obo/HP_0000364 Hearing abnormality http://purl.obolibrary.org/obo/HP_0031704 Abnormal ear physiology An abnormality of the sensory perception of sound. http://purl.obolibrary.org/obo/HP_0000478 Abnormality of the eye http://purl.obolibrary.org/obo/HP_0000118 Phenotypic abnormality Any abnormality of the eye, including location, spacing, and intraocular abnormalities. http://purl.obolibrary.org/obo/HP_0000496 Abnormality of eye movement http://purl.obolibrary.org/obo/HP_0012373 Abnormal eye physiology An abnormality in voluntary or involuntary eye movements or their control. http://purl.obolibrary.org/obo/HP_0000504 Abnormality of vision http://purl.obolibrary.org/obo/HP_0012373 Abnormal eye physiology Abnormality of eyesight (visual perception). http://purl.obolibrary.org/obo/HP_0000505 Visual impairment http://purl.obolibrary.org/obo/HP_0000504 Abnormality of vision Visual impairment (or vision impairment) is vision loss (of a person) to such a degree as to qualify as an additional support need through a significant limitation of visual capability resulting from either disease, trauma, or congenital or degenerative conditions that cannot be corrected by conventional means, such as refractive correction, medication, or surgery. http://purl.obolibrary.org/obo/HP_0000549 Abnormal conjugate eye movement http://purl.obolibrary.org/obo/HP_0000496 Abnormality of eye movement Any deviation from the normal motor coordination of the eyes that allows for bilateral fixation on a single object. http://purl.obolibrary.org/obo/HP_0000570 Abnormal saccadic eye movements http://purl.obolibrary.org/obo/HP_0000496 Abnormality of eye movement An abnormality of eye movement characterized by impairment of fast (saccadic) eye movements. http://purl.obolibrary.org/obo/HP_0000571 Hypometric saccades http://purl.obolibrary.org/obo/HP_0000570 Abnormal saccadic eye movements Saccadic undershoot, i.e., a saccadic eye movement that has less than the magnitude that would be required to gain fixation of the object. http://purl.obolibrary.org/obo/HP_0000598 Abnormality of the ear http://purl.obolibrary.org/obo/HP_0000118 Phenotypic abnormality An abnormality of the ear. http://purl.obolibrary.org/obo/HP_0000708 Behavioral abnormality http://purl.obolibrary.org/obo/HP_0012638 Abnormality of nervous system physiology An abnormality of mental functioning including various affective, behavioural, cognitive and perceptual abnormalities. http://purl.obolibrary.org/obo/HP_0000712 Emotional lability http://purl.obolibrary.org/obo/HP_0031466 Impairment in personality functioning Unstable emotional experiences and frequent mood changes; emotions that are easily aroused, intense, and/or out of proportion to events and circumstances. http://purl.obolibrary.org/obo/HP_0000716 Depressivity http://purl.obolibrary.org/obo/HP_0031466 Impairment in personality functioning Frequent feelings of being down, miserable, and/or hopeless; difficulty recovering from such moods; pessimism about the future; pervasive shame; feeling of inferior self-worth; thoughts of suicide and suicidal behavior. http://purl.obolibrary.org/obo/HP_0000733 Stereotypy http://purl.obolibrary.org/obo/MONDO_0017657 rare paroxysmal movement disorder A stereotypy is a repetitive, simple movement that can be voluntarily suppressed. Stereotypies are typically simple back-and-forth movements such as waving of flapping the hands or arms, and they do not involve complex sequences or movement fragments. Movement is often but not always rhythmic and may involve fingers, wrists, or more proximal portions of the upper extremity. The lower extremity is not typically involved. Stereotypies are more commonly bilateral than unilateral. http://purl.obolibrary.org/obo/HP_0000805 Enuresis http://purl.obolibrary.org/obo/HP_0000009 Functional abnormality of the bladder Lack of the ability to control the urinary bladder leading to involuntary urination at an age where control of the bladder should already be possible. http://purl.obolibrary.org/obo/HP_0000818 Abnormality of the endocrine system http://purl.obolibrary.org/obo/HP_0000118 Phenotypic abnormality An abnormality of the endocrine system. http://purl.obolibrary.org/obo/HP_0000826 Precocious puberty http://purl.obolibrary.org/obo/HP_0100000 Early onset of sexual maturation The onset of secondary sexual characteristics before a normal age. Although it is difficult to define normal age ranges because of the marked variation with which puberty begins in normal children, precocious puberty can be defined as the onset of puberty before the age of 8 years in girls or 9 years in boys. http://purl.obolibrary.org/obo/HP_0000951 Abnormality of the skin http://purl.obolibrary.org/obo/HP_0001574 Abnormality of the integument An abnormality of the skin. http://purl.obolibrary.org/obo/HP_0001041 Facial erythema http://purl.obolibrary.org/obo/HP_0010783 Erythema Redness of the skin of the face, caused by hyperemia of the capillaries in the lower layers of the skin. http://purl.obolibrary.org/obo/HP_0001279 Syncope https://bio.scai.fraunhofer.de/ontology/epilepsy#epilepsy_imitator epilepsy imitator Syncope refers to a generalized weakness of muscles with loss of postural tone, inability to stand upright, and loss of consciousness. Once the patient is in a horizontal position, blood flow to the brain is no longer hindered by gravitation and consciousness is regained. Unconsciousness usually lasts for seconds to minutes. Headache and drowsiness (which usually follow seizures) do not follow a syncopal attack. Syncope results from a sudden impairment of brain metabolism usually due to a reduction in cerebral blood flow. http://purl.obolibrary.org/obo/HP_0001311 Abnormal nervous system electrophysiology http://purl.obolibrary.org/obo/HP_0012638 Abnormality of nervous system physiology An abnormality of the function of the electrical signals with which nerve cells communicate with each other or with muscles as measured by electrophysiological investigations. http://purl.obolibrary.org/obo/HP_0001336 Myoclonus http://purl.obolibrary.org/obo/HP_0004305 Involuntary movements Very brief, involuntary random muscular contractions occurring at rest, in response to sensory stimuli, or accompanying voluntary movements. http://purl.obolibrary.org/obo/HP_0001342 Cerebral hemorrhage http://purl.obolibrary.org/obo/HP_0011025 Abnormal cardiovascular system physiology Hemorrhage into the parenchyma of the brain. http://purl.obolibrary.org/obo/HP_0001371 Flexion contracture http://purl.obolibrary.org/obo/HP_0100261 Abnormal tendon morphology A flexion contracture is a bent (flexed) joint that cannot be straightened actively or passively. It is thus a chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement of joints. http://purl.obolibrary.org/obo/HP_0001518 Small for gestational age http://purl.obolibrary.org/obo/HP_0004325 Decreased body weight Smaller than normal size according to sex and gestational age related norms, defined as a weight below the 10th percentile for the gestational age. http://purl.obolibrary.org/obo/HP_0001574 Abnormality of the integument http://purl.obolibrary.org/obo/HP_0000118 Phenotypic abnormality An abnormality of the integument, which consists of the skin and the superficial fascia. http://purl.obolibrary.org/obo/HP_0001626 Abnormality of the cardiovascular system http://purl.obolibrary.org/obo/HP_0000118 Phenotypic abnormality Any abnormality of the cardiovascular system. http://purl.obolibrary.org/obo/HP_0001871 Abnormality of blood and blood-forming tissues http://purl.obolibrary.org/obo/HP_0000118 Phenotypic abnormality An abnormality of the hematopoietic system. http://purl.obolibrary.org/obo/HP_0001892 Abnormal bleeding http://purl.obolibrary.org/obo/HP_0001871 Abnormality of blood and blood-forming tissues An abnormal susceptibility to bleeding, often referred to as a bleeding diathesis. A bleeding diathesis may be related to vascular, platelet and coagulation defects. http://purl.obolibrary.org/obo/HP_0001999 Abnormal facial shape http://purl.obolibrary.org/obo/HP_0000271 Abnormality of the face An abnormal morphology (form) of the face or its components. http://purl.obolibrary.org/obo/HP_0002011 Morphological abnormality of the central nervous system http://purl.obolibrary.org/obo/HP_0012639 Abnormality of nervous system morphology A structural abnormality of the central nervous system. http://purl.obolibrary.org/obo/HP_0002013 Vomiting http://purl.obolibrary.org/obo/HP_0002017 Nausea and vomiting Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions. http://purl.obolibrary.org/obo/HP_0002086 Abnormality of the respiratory system http://purl.obolibrary.org/obo/HP_0000118 Phenotypic abnormality An abnormality of the respiratory system, which include the airways, lungs, and the respiratory muscles. http://purl.obolibrary.org/obo/HP_0002123 Generalized myoclonic seizures https://bio.scai.fraunhofer.de/ontology/epilepsy#generalized_motor_onset_seizure generalized motor onset seizure Seizures with sudden, brief (< 100 msec) involuntary single or multiple contraction(s) of muscles(s) or muscle groups of variable topography (axial, proximal limb, distal). http://purl.obolibrary.org/obo/HP_0002126 Polymicrogyria http://purl.obolibrary.org/obo/NCIT_C84834 Malformations of Cortical Development Polymicrogyria is a congenital malformation of the cerebral cortex characterized by abnormal cortical layering (lamination) and an excessive number of small gyri (folds). http://purl.obolibrary.org/obo/HP_0002133 Status epilepticus http://purl.obolibrary.org/obo/SYMP_0000124 seizure Status epilepticus is a type of prolonged seizure. The definition is based on both the length of the seizure and the time point (t1) beyond which the seizure should be regarded as continuous seizure activity. The second time point (t2) is the time of ongoing seizure activity after which there is a risk of long-term consequences. See the comment for information on t1 and t2. http://purl.obolibrary.org/obo/HP_0002138 Subarachnoid hemorrhage http://purl.obolibrary.org/obo/HP_0001342 Cerebral hemorrhage Hemorrhage occurring between the arachnoid mater and the pia mater. http://purl.obolibrary.org/obo/HP_0002170 Intracranial hemorrhage http://purl.obolibrary.org/obo/HP_0011029 Internal hemorrhage Hemorrhage occurring within the skull. http://purl.obolibrary.org/obo/HP_0002172 Postural instability http://purl.obolibrary.org/obo/HP_0100022 Abnormality of movement A tendency to fall or the inability to keep oneself from falling; imbalance. The retropulsion test is widely regarded as the gold standard to evaluate postural instability, Use of the retropulsion test includes a rapid balance perturbation in the backward direction, and the number of balance correcting steps (or total absence thereof) is used to rate the degree of postural instability. Healthy subjects correct such perturbations with either one or two large steps, or without taking any steps, hinging rapidly at the hips while swinging the arms forward as a counterweight. In patients with balance impairment, balance correcting steps are often too small, forcing patients to take more than two steps. Taking three or more steps is generally considered to be abnormal, and taking more than five steps is regarded as being clearly abnormal. Markedly affected patients continue to step backward without ever regaining their balance and must be caught by the examiner (this would be called true retropulsion). Even more severely affected patients fail to correct entirely, and fall backward like a pushed toy soldier, without taking any corrective steps. http://purl.obolibrary.org/obo/HP_0002197 Generalized-onset seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#seizure_classification seizure classification Seizures of with initial involvement of both cerebral hemispheres. http://purl.obolibrary.org/obo/HP_0002266 Focal clonic seizure http://purl.obolibrary.org/obo/HP_0011153 Focal motor seizure A focal clonic seizure is a type of focal motor seizure characterized by sustained rhythmic jerking, that is regularly repetitive. http://purl.obolibrary.org/obo/HP_0002282 Gray matter heterotopia http://purl.obolibrary.org/obo/NCIT_C84834 Malformations of Cortical Development Heterotopia or neuronal heterotopia are macroscopic clusters of misplaced neurons (gray matter), most often situated along the ventricular walls or within the subcortical white matter. http://purl.obolibrary.org/obo/HP_0002307 Drooling http://purl.obolibrary.org/obo/HP_0003781 Excessive salivation Habitual flow of saliva out of the mouth. http://purl.obolibrary.org/obo/HP_0002315 Headache http://purl.obolibrary.org/obo/HP_0012638 Abnormality of nervous system physiology Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve. http://purl.obolibrary.org/obo/HP_0002349 Focal aware seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_seizure_classification_by_onset_feature focal seizure classification by onset feature A type of focal-onset seizure in which awareness is preserved. Awareness during a seizure is defined as the patient being fully aware of themself and their environment throughout the seizure, even if immobile. http://purl.obolibrary.org/obo/HP_0002353 EEG abnormality http://purl.obolibrary.org/obo/HP_0030178 Abnormality of central nervous system electrophysiology Abnormality observed by electroencephalogram (EEG), which is used to record of the brain's spontaneous electrical activity from multiple electrodes placed on the scalp. http://purl.obolibrary.org/obo/HP_0002384 Focal impaired awareness seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_seizure_classification_by_onset_feature focal seizure classification by onset feature A type of focal-onset saeizure characterized by impaired awareness. Awareness during a seizure is defined as the patient being fully aware of themself and their environment throughout the seizure, even if immobile. If awareness is impaired at any point during the seizure, the seizure is a focal impaired awareness seizure. The degree of loss of awareness may vary. http://purl.obolibrary.org/obo/HP_0002392 EEG with polyspike wave complexes http://purl.obolibrary.org/obo/HP_0010850 EEG with spike-wave complexes The presence of complexes of repetitive spikes and waves in EEG. http://purl.obolibrary.org/obo/HP_0002411 Myokymia http://purl.obolibrary.org/obo/HP_0100022 Abnormality of movement Myokymia consists of involuntary, fine, continuous, undulating contractions that spread across the affected striated muscle. http://purl.obolibrary.org/obo/HP_0002444 Hypothalamic hamartoma http://purl.obolibrary.org/obo/NCIT_C84834 Malformations of Cortical Development The presence of a hamartoma of the hypothalamus. http://purl.obolibrary.org/obo/HP_0002493 Upper motor neuron dysfunction http://purl.obolibrary.org/obo/HP_0011442 Abnormality of central motor function A functional anomaly of the upper motor neuron. The upper motor neurons are neurons of the primary motor cortex which project to the brainstem and spinal chord via the corticonuclear, corticobulbar and corticospinal (pyramidal) tracts. They are involved in control of voluntary movements. Dysfunction leads to weakness, impairment of fine motor movements, spasticity, hyperreflexia and abnormal pyramidal signs. http://purl.obolibrary.org/obo/HP_0002521 Hypsarrhythmia http://purl.obolibrary.org/obo/HP_0011198 EEG with generalized epileptiform discharges Hypsarrhythmia is abnormal interictal high amplitude waves and a background of irregular spikes. There is continuous (during wakefulness), high-amplitude (>200 Hz), generalized polymorphic slowing with no organized background and multifocal spikes demonstrated by electroencephalography (EEG). http://purl.obolibrary.org/obo/HP_0002579 Gastrointestinal dysmotility http://purl.obolibrary.org/obo/HP_0030895 Abnormal gastrointestinal motility Abnormal intestinal contractions, such as spasms and intestinal paralysis, related to the loss of the ability of the gut to coordinate muscular activity because of endogenous or exogenous causes. http://purl.obolibrary.org/obo/HP_0002597 Abnormality of the vasculature http://purl.obolibrary.org/obo/HP_0001626 Abnormality of the cardiovascular system An abnormality of the vasculature. http://purl.obolibrary.org/obo/HP_0002664 Neoplasm https://bio.scai.fraunhofer.de/ontology/epilepsy#structural_etiology structural etiology An organ or organ-system abnormality that consists of uncontrolled autonomous cell-proliferation which can occur in any part of the body as a benign or malignant neoplasm (tumour). http://purl.obolibrary.org/obo/HP_0002715 Abnormality of the immune system http://purl.obolibrary.org/obo/HP_0000118 Phenotypic abnormality An abnormality of the immune system. http://purl.obolibrary.org/obo/HP_0002781 Upper airway obstruction http://purl.obolibrary.org/obo/HP_0001279 Syncope Increased resistance to the passage of air in the upper airway. http://purl.obolibrary.org/obo/HP_0002888 Ependymoma http://purl.obolibrary.org/obo/MONDO_0021042 glioma The presence of an ependymoma of the central nervous system. http://purl.obolibrary.org/obo/HP_0002901 Hypocalcemia http://purl.obolibrary.org/obo/HP_0004363 Abnormal circulating calcium concentration An abnormally decreased calcium concentration in the blood. http://purl.obolibrary.org/obo/HP_0002902 Hyponatremia http://purl.obolibrary.org/obo/HP_0010931 Abnormal blood sodium concentration An abnormally decreased sodium concentration in the blood. http://purl.obolibrary.org/obo/HP_0002917 Hypomagnesemia http://purl.obolibrary.org/obo/HP_0004921 Abnormal magnesium concentration An abnormally decreased magnesium concentration in the blood. http://purl.obolibrary.org/obo/HP_0002921 Abnormality of the cerebrospinal fluid http://purl.obolibrary.org/obo/HP_0002011 Morphological abnormality of the central nervous system An abnormality of the cerebrospinal fluid (CSF). http://purl.obolibrary.org/obo/HP_0003011 Abnormality of the musculature http://purl.obolibrary.org/obo/HP_0000118 Phenotypic abnormality Abnormality originating in one or more muscles, i.e., of the set of muscles of body. http://purl.obolibrary.org/obo/HP_0003111 Abnormal blood ion concentration http://purl.obolibrary.org/obo/HP_0032180 Abnormal circulating metabolite concentration Abnormality of the homeostasis (concentration) of a monoatomic ion. http://purl.obolibrary.org/obo/HP_0003228 Hypernatremia http://purl.obolibrary.org/obo/HP_0010931 Abnormal blood sodium concentration An abnormally increased sodium concentration in the blood. http://purl.obolibrary.org/obo/HP_0003236 Elevated serum creatine kinase http://purl.obolibrary.org/obo/HP_0040081 Abnormal circulating creatine kinase concentration An elevation of the level of the enzyme creatine kinase (also known as creatine phosphokinase, CPK; EC 2.7.3.2) in the blood. CPK levels can be elevated in a number of clinical disorders such as myocardial infarction, rhabdomyolysis, and muscular dystrophy. http://purl.obolibrary.org/obo/HP_0003394 Muscle spasm http://purl.obolibrary.org/obo/HP_0011804 Abnormal muscle physiology Sudden and involuntary contractions of one or more muscles. http://purl.obolibrary.org/obo/HP_0003549 Abnormality of connective tissue http://purl.obolibrary.org/obo/HP_0000118 Phenotypic abnormality Any abnormality of the soft tissues, including both connective tissue (tendons, ligaments, fascia, fibrous tissues, and fat). http://purl.obolibrary.org/obo/HP_0003552 Muscle stiffness http://purl.obolibrary.org/obo/HP_0011804 Abnormal muscle physiology A condition in which muscles cannot be moved quickly without accompanying pain or spasm. http://purl.obolibrary.org/obo/HP_0003781 Excessive salivation http://purl.obolibrary.org/obo/HP_0100755 Abnormality of salivation Excessive production of saliva. http://purl.obolibrary.org/obo/HP_0004305 Involuntary movements http://purl.obolibrary.org/obo/HP_0100022 Abnormality of movement Involuntary contractions of muscle leading to involuntary movements of extremities, neck, trunk, or face. http://purl.obolibrary.org/obo/HP_0004323 Abnormality of body weight http://purl.obolibrary.org/obo/HP_0001507 Growth abnormality An abnormal increase or decrease of weight or an abnormal distribution of mass in the body. http://purl.obolibrary.org/obo/HP_0004325 Decreased body weight http://purl.obolibrary.org/obo/HP_0004323 Abnormality of body weight Abnormally low body weight. http://purl.obolibrary.org/obo/HP_0004327 Abnormal vitreous humor morphology http://purl.obolibrary.org/obo/HP_0004329 Abnormal posterior eye segment morphology Any structural anomaly of the vitreous body. http://purl.obolibrary.org/obo/HP_0004363 Abnormal circulating calcium concentration http://purl.obolibrary.org/obo/HP_0010927 Abnormal blood inorganic cation concentration Any deviation from the normal concentration of calcium in the blood circulation. http://purl.obolibrary.org/obo/HP_0004374 Hemiplegia/hemiparesis http://purl.obolibrary.org/obo/HP_0010549 Weakness due to upper motor neuron dysfunction Loss of strength in the arm, leg, and sometimes face on one side of the body. Hemiplegia refers to a severe or complete loss of strength, whereas hemiparesis refers to a relatively mild loss of strength. http://purl.obolibrary.org/obo/HP_0004418 Thrombophlebitis http://purl.obolibrary.org/obo/HP_0004936 Venous thrombosis Inflammation of a vein associated with venous thrombosis (blood clot formation within the vein). http://purl.obolibrary.org/obo/HP_0004921 Abnormal magnesium concentration http://purl.obolibrary.org/obo/HP_0010927 Abnormal blood inorganic cation concentration An abnormality of magnesium ion homeostasis. http://purl.obolibrary.org/obo/HP_0004936 Venous thrombosis http://purl.obolibrary.org/obo/HP_0001977 Abnormal thrombosis Formation of a blood clot (thrombus) inside a vein, causing the obstruction of blood flow. http://purl.obolibrary.org/obo/HP_0007359 Focal-onset seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#seizure_classification seizure classification Seizures of which initial semiology indicates, or is consistent with, initial activation of only part of one cerebral hemisphere. http://purl.obolibrary.org/obo/HP_0010549 Weakness due to upper motor neuron dysfunction http://purl.obolibrary.org/obo/HP_0002493 Upper motor neuron dysfunction Paralysis of voluntary muscles means loss of contraction due to interruption of one or more motor pathways from the brain to the muscle fibers. Although the word paralysis is often used interchangeably to mean either complete or partial loss of muscle strength, it is preferable to use paralysis or plegia for complete or severe loss of muscle strength, and paresis for partial or slight loss. Paralysis due to lesions of the principle motor tracts is related to a lesion in the corticospinal, corticobulbar or brainstem descending (subcorticospinal) neurons. http://purl.obolibrary.org/obo/HP_0010783 Erythema http://purl.obolibrary.org/obo/HP_0011276 Vascular skin abnormality Redness of the skin, caused by hyperemia of the capillaries in the lower layers of the skin. http://purl.obolibrary.org/obo/HP_0010850 EEG with spike-wave complexes http://purl.obolibrary.org/obo/HP_0011198 EEG with generalized epileptiform discharges Complexes of spikes (<70 ms) and sharp waves (70-200 ms), which are sharp transient waves that have a strong association with epilepsy, in cerebral electrical activity recorded along the scalp by electroencephalography (EEG). http://purl.obolibrary.org/obo/HP_0010876 Abnormal circulating protein level http://purl.obolibrary.org/obo/HP_0032180 Abnormal circulating metabolite concentration An abnormal level of a circulating protein in the blood. http://purl.obolibrary.org/obo/HP_0010931 Abnormal blood sodium concentration http://purl.obolibrary.org/obo/HP_0010930 Abnormal blood monovalent inorganic cation concentration An abnormal concentration of sodium. http://purl.obolibrary.org/obo/HP_0010936 Abnormality of the lower urinary tract http://purl.obolibrary.org/obo/HP_0000079 Abnormality of the urinary system An abnormality of the lower urinary tract. http://purl.obolibrary.org/obo/HP_0010978 Abnormality of immune system physiology http://purl.obolibrary.org/obo/HP_0002715 Abnormality of the immune system A functional abnormality of the immune system. http://purl.obolibrary.org/obo/HP_0011004 Abnormal systemic arterial morphology http://purl.obolibrary.org/obo/HP_0025015 Abnormal vascular morphology An abnormality of the systemic arterial tree, which consists of the aorta and other systemic arteries. http://purl.obolibrary.org/obo/HP_0011025 Abnormal cardiovascular system physiology http://purl.obolibrary.org/obo/HP_0001626 Abnormality of the cardiovascular system Abnormal functionality of the cardiovascular system. http://purl.obolibrary.org/obo/HP_0011121 Abnormality of skin morphology http://purl.obolibrary.org/obo/HP_0000951 Abnormality of the skin Any morphological abnormality of the skin. http://purl.obolibrary.org/obo/HP_0011153 Focal motor seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_seizure_classification_by_onset_feature focal seizure classification by onset feature A type of focal-onset seizure characterized by a motor sign as its initial semiological manifestation. http://purl.obolibrary.org/obo/HP_0011198 EEG with generalized epileptiform discharges http://purl.obolibrary.org/obo/HP_0011182 Interictal epileptiform activity EEG discharges recorded on the entire scalp typically seen in persons with epilepsy. http://purl.obolibrary.org/obo/HP_0011354 Generalized abnormality of skin http://purl.obolibrary.org/obo/HP_0011121 Abnormality of skin morphology An abnormality of the skin that is not localized to any one particular region. http://purl.obolibrary.org/obo/HP_0011442 Abnormality of central motor function http://purl.obolibrary.org/obo/HP_0012638 Abnormality of nervous system physiology An anomaly of the control or production of movement in the central nervous system. http://purl.obolibrary.org/obo/HP_0011446 Abnormality of higher mental function http://purl.obolibrary.org/obo/HP_0012638 Abnormality of nervous system physiology Cognitive, psychiatric or memory anomaly. http://purl.obolibrary.org/obo/HP_0011450 Unusual CNS infection http://purl.obolibrary.org/obo/HP_0002011 Morphological abnormality of the central nervous system A type of infection of the central nervous system that can be regarded as a sign of a pathological susceptibility to infection. http://purl.obolibrary.org/obo/HP_0011729 Abnormality of joint mobility http://purl.obolibrary.org/obo/HP_0011843 Abnormality of skeletal physiology An abnormality in the range and ease of motion of joints across their normal range. http://purl.obolibrary.org/obo/HP_0011804 Abnormal muscle physiology http://purl.obolibrary.org/obo/HP_0003011 Abnormality of the musculature A functional abnormality of a skeletal muscle. http://purl.obolibrary.org/obo/HP_0011805 Abnormal skeletal muscle morphology http://purl.obolibrary.org/obo/HP_0003011 Abnormality of the musculature A structural abnormality of a skeletal muscle. http://purl.obolibrary.org/obo/HP_0011842 Abnormality of skeletal morphology http://purl.obolibrary.org/obo/HP_0000924 Abnormality of the skeletal system An abnormality of the form, structure, or size of the skeletal system. http://purl.obolibrary.org/obo/HP_0011843 Abnormality of skeletal physiology http://purl.obolibrary.org/obo/HP_0000924 Abnormality of the skeletal system An abnormality of the function of the skeletal system. http://purl.obolibrary.org/obo/HP_0012372 Abnormal eye morphology http://purl.obolibrary.org/obo/HP_0000478 Abnormality of the eye A structural anomaly of the globe of the eye, or bulbus oculi. http://purl.obolibrary.org/obo/HP_0012373 Abnormal eye physiology http://purl.obolibrary.org/obo/HP_0000478 Abnormality of the eye A functional anomaly of the eye. http://purl.obolibrary.org/obo/HP_0012443 Abnormality of brain morphology http://purl.obolibrary.org/obo/HP_0002011 Morphological abnormality of the central nervous system A structural abnormality of the brain, which has as its parts the forebrain, midbrain, and hindbrain. http://purl.obolibrary.org/obo/HP_0012638 Abnormality of nervous system physiology http://purl.obolibrary.org/obo/HP_0000707 Abnormality of the nervous system A functional anomaly of the nervous system. http://purl.obolibrary.org/obo/HP_0012639 Abnormality of nervous system morphology http://purl.obolibrary.org/obo/HP_0000707 Abnormality of the nervous system A structural anomaly of the nervous system. http://purl.obolibrary.org/obo/HP_0012719 Functional abnormality of the gastrointestinal tract http://purl.obolibrary.org/obo/HP_0011024 Abnormality of the gastrointestinal tract Abnormal functionality of the gastrointestinal tract. http://purl.obolibrary.org/obo/HP_0100000 Early onset of sexual maturation http://purl.obolibrary.org/obo/HP_0008373 Puberty and gonadal disorders An early onset of puberty, in this case early does not refer to precocious. http://purl.obolibrary.org/obo/HP_0100022 Abnormality of movement http://purl.obolibrary.org/obo/HP_0012638 Abnormality of nervous system physiology An abnormality of movement with a neurological basis characterized by changes in coordination and speed of voluntary movements. http://purl.obolibrary.org/obo/HP_0100543 Cognitive impairment http://purl.obolibrary.org/obo/HP_0011446 Abnormality of higher mental function Abnormality in the process of thought including the ability to process information. http://purl.obolibrary.org/obo/UBERON_0001871 temporal lobe http://purl.obolibrary.org/obo/UBERON_0016526 lobe of cerebral hemisphere Lower lateral part of the cerebral hemisphere. (MSH) http://purl.obolibrary.org/obo/UBERON_0001893 telencephalon http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain Part of the forebrain consisting of paired olfactory bulbs and cerebral hemispheres. http://purl.obolibrary.org/obo/UBERON_0001894 diencephalon http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain The division of the forebrain that develops from the foremost primary cerebral vesicle. http://purl.obolibrary.org/obo/UBERON_0002021 occipital lobe http://purl.obolibrary.org/obo/UBERON_0016526 lobe of cerebral hemisphere Posterior part of the cerebral hemisphere (MSH) http://purl.obolibrary.org/obo/UBERON_0002037 cerebellum http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement[MESH]. A large dorsally projecting part of the brain concerned especially with the coordination of muscles and the maintenance of bodily equilibrium, situated between the brain stem and the back of the cerebrum , and formed in humans of two lateral lobes and a median lobe[BTO]. Brain structure derived from the anterior hindbrain, and perhaps including posterior midbrain. The cerebellum plays a role in somatic motor function, the control of muscle tone, and balance[ZFA]. http://purl.obolibrary.org/obo/UBERON_0002286 third ventricle http://purl.obolibrary.org/obo/UBERON_0004086 brain ventricle Part of the ventricular system of the brain, forming a single large cavity in the midline of the diencephalon; it is continuous with the lateral ventricles through the interventricular foramen and the fourth ventricle through the cerebral aqueduct. (Maryann Martone) http://purl.obolibrary.org/obo/UBERON_0002420 basal ganglion http://purl.obolibrary.org/obo/UBERON_0007245 nuclear complex of neuraxis An individual member of a collection of basal ganglia. Basal ganglia are subcortical masses of gray matter in the forebrain and midbrain that are richly interconnected and so viewed as a functional system. The nuclei usually included are the caudate nucleus (caudoputamen in rodents), putamen, globus pallidus, substantia nigra (pars compacta and pars reticulata) and the subthalamic nucleus. Some also include the nucleus accumbens and ventral pallidum[NIF,modified]. http://purl.obolibrary.org/obo/UBERON_0004086 brain ventricle http://purl.obolibrary.org/obo/UBERON_0005358 ventricle of nervous system one of the system of communicating cavities in the brain that are continuous with the central canal of the spinal cord, that like it are derived from the medullary canal of the embryo, that are lined with an epithelial ependyma, and that contain a serous fluid http://purl.obolibrary.org/obo/BFO_0000002 continuant http://purl.obolibrary.org/obo/BFO_0000001 entity An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts. http://purl.obolibrary.org/obo/BFO_0000003 occurrent http://purl.obolibrary.org/obo/BFO_0000001 entity An entity that has temporal parts and that happens, unfolds or develops through time. http://purl.obolibrary.org/obo/BFO_0000004 independent continuant http://purl.obolibrary.org/obo/BFO_0000002 continuant b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002]) http://purl.obolibrary.org/obo/BFO_0000015 process http://purl.obolibrary.org/obo/BFO_0000003 occurrent An occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. http://purl.obolibrary.org/obo/BFO_0000020 specifically dependent continuant http://purl.obolibrary.org/obo/BFO_0000002 continuant A continuant that inheres in or is borne by other entities. Every instance of A requires some specific instance of B which must always be the same. http://purl.obolibrary.org/obo/BFO_0000031 generically dependent continuant http://purl.obolibrary.org/obo/BFO_0000002 continuant b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001]) http://purl.obolibrary.org/obo/BFO_0000035 process boundary http://purl.obolibrary.org/obo/BFO_0000003 occurrent p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001]) http://purl.obolibrary.org/obo/BFO_0000140 continuant fiat boundary http://purl.obolibrary.org/obo/BFO_0000141 immaterial entity b is a continuant fiat boundary = Def. b is an immaterial entity that is of zero, one or two dimensions and does not include a spatial region as part. (axiom label in BFO2 Reference: [029-001]) http://purl.obolibrary.org/obo/BFO_0000144 process profile http://purl.obolibrary.org/obo/BFO_0000015 process b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002]) http://purl.obolibrary.org/obo/BFO_0000145 relational quality http://purl.obolibrary.org/obo/BFO_0000019 quality b is a relational quality = Def. for some independent continuants c, d and for some time t: b quality_of c at t & b quality_of d at t. (axiom label in BFO2 Reference: [057-001]) http://purl.obolibrary.org/obo/IAO_0000030 information content entity http://purl.obolibrary.org/obo/BFO_0000031 generically dependent continuant An information content entity is an entity that is generically dependent on some artifact and stands in relation of aboutness to some entity http://purl.obolibrary.org/obo/IAO_0000109 measurement datum http://purl.obolibrary.org/obo/IAO_0000027 data item A measurement datum is an information content entity that is a recording of the output of a measurement such as produced by a device. http://purl.obolibrary.org/obo/IDO_0000586 infection http://purl.obolibrary.org/obo/BFO_0000040 material entity A part of an extended organism that itself has as part a population of one or more infectious agents and that (1) exists as a result of processes initiated by members of the infectious agent population and is (2) clinically abnormal in virtue of the presence of this infectious agent population, or (3) has a disposition to bring clinical abnormality to immunocompetent organisms of the same Species as the host (the organism corresponding to the extended organism) through transmission of a member or offspring of a member of the infectious agent population. http://purl.obolibrary.org/obo/OBI_0000011 planned process http://purl.obolibrary.org/obo/BFO_0000015 process A processual entity that realizes a plan which is the concretization of a plan specification. http://purl.obolibrary.org/obo/OBI_0000047 processed material http://purl.obolibrary.org/obo/BFO_0000040 material entity Is a material entity that is created or changed during material processing. http://purl.obolibrary.org/obo/OBI_0000454 extracellular electrophysiology recording assay http://purl.obolibrary.org/obo/OBI_0000070 assay An electrophysiology recording assay where the recording location of the electrode is extracellular http://purl.obolibrary.org/obo/OBI_0000626 DNA sequencing http://purl.obolibrary.org/obo/ERO_0001286 nucleic acid assay DNA sequencing is a sequencing process which uses deoxyribonucleic acid as input and results in a the creation of DNA sequence information artifact using a DNA sequencer instrument. http://purl.obolibrary.org/obo/OBI_0001865 assay array http://purl.obolibrary.org/obo/OBI_0000968 device A device made to be used in an analyte assay for immobilization of substances that bind the analyte at regular spatial positions on a surface. http://purl.obolibrary.org/obo/OBI_0400147 microarray http://purl.obolibrary.org/obo/OBI_0001865 assay array A processed material that is made to be used in an analyte assay. It consists of a physical immobilisation matrix in which substances that bind the analyte are placed in regular spatial position. http://purl.obolibrary.org/obo/OBI_1110049 allergy http://purl.obolibrary.org/obo/HP_0010978 Abnormality of immune system physiology is a disease in which an abnormally strong inflammatory immune response is triggered against non-self entities, and the immune response has no protective effect http://purl.obolibrary.org/obo/OGMS_0000015 clinical history http://purl.obolibrary.org/obo/OGMS_0000123 clinical data item A series of statements representing health-relevant qualities of a patient and of a patient's family. http://purl.obolibrary.org/obo/OGMS_0000090 treatment http://purl.obolibrary.org/obo/OBI_0000011 planned process A planned process whose completion is hypothesized by a health care provider to eliminate, prevent, or alleviate the signs and symptoms of a disorder or pathological process http://purl.obolibrary.org/obo/PATO_0001995 organismal quality http://purl.obolibrary.org/obo/PATO_0001241 physical object quality A quality that inheres in an entire organism or part of an organism. http://purl.obolibrary.org/obo/OMIABIS_0001041 surgical procedure http://purl.obolibrary.org/obo/OBI_0000011 planned process A planned process that uses operative manual and instrumental techniques on a patient to investigate and/or treat a pathological condition such as disease or injury, or to help improve bodily function or appearance. http://purl.obolibrary.org/obo/SYMP_0000515 hiccough http://purl.obolibrary.org/obo/SYMP_0000514 respiratory system and chest symptom Hiccough is a respiratory system and chest symptom characterized by a spasmodic inhalation with closure of the glottis accompanied by a peculiar sound. http://purl.obolibrary.org/obo/SYMP_0000020 dehydration http://purl.obolibrary.org/obo/SYMP_0000473 nutrition, metabolism, and development symptom Dehydration is a nutrition, metabolism, and development symptom characterized by an abnormal depletion of body fluids. http://purl.obolibrary.org/obo/SYMP_0000089 meningoencephalitis https://bio.scai.fraunhofer.de/ontology/epilepsy#infectious_etiology infectious etiology Meningoencephalitis is a nervous system symptom characterized as an inflammation of the brain and meninges. http://purl.obolibrary.org/obo/SYMP_0000156 thirst http://purl.obolibrary.org/obo/SYMP_0000567 general symptom Thirst is a general symptom characterized by a sensation of dryness in the mouth and throat associated with a desire for liquids. http://purl.obolibrary.org/obo/SYMP_0000226 atrial fibrillation http://purl.obolibrary.org/obo/SYMP_0000898 cardiac fibrillation A cardiac fibrillation consisting of a very rapid uncoordinated contractions of the atria of the heart resulting in a lack of synchronism between heartbeat and pulse beat. http://purl.obolibrary.org/obo/SYMP_0000231 bradycardia http://purl.obolibrary.org/obo/SYMP_0000287 arrhythmia Bradycardia is a cardiovascular system symptom consisting of a relatively slow heart action whether physiological or pathological. http://purl.obolibrary.org/obo/SYMP_0000287 arrhythmia http://purl.obolibrary.org/obo/SYMP_0000528 cardiovascular system symptom Arrhythmia is a cardiovascular system symptom consisting of an alteration in rhythm of the heartbeat either in time or force. http://purl.obolibrary.org/obo/SYMP_0000290 belching http://purl.obolibrary.org/obo/SYMP_0000459 digestive system symptom Belching is a digestive system symptom involving the sudden expulsion of gas from the stomach through the mouth. http://purl.obolibrary.org/obo/SYMP_0000399 vertigo http://purl.obolibrary.org/obo/SYMP_0000610 dizziness Vertigo is a dizziness characterized by a specific type of dizziness, a major symptom of a balance disorder. It is the sensation of spinning or swaying while the body is stationary with respect to the surroundings. http://purl.obolibrary.org/obo/SYMP_0000408 cataplexy http://purl.obolibrary.org/obo/SYMP_0000183 muscle symptom Cataplexy is a muscle symptom characterized by a sudden loss of muscle control with retention of clear consciousness that follows a strong emotional stimulus (as elation, surprise, or anger) and is a characteristic symptom of narcolepsy. http://purl.obolibrary.org/obo/SYMP_0000414 dysarthria http://purl.obolibrary.org/obo/SYMP_0000410 neurological and physiological symptom Dysarthria is a neurological and physiological symptom characterized by a difficulty in articulating words due to disease of the central nervous system. http://purl.obolibrary.org/obo/SYMP_0000428 hypoventilation http://purl.obolibrary.org/obo/SYMP_0000598 respiratory abnormality Hypoventilation is a respiratory abnormality characterized by a deficient ventilation of the lungs that results in reduction in the oxygen content or increase in the carbon dioxide content of the blood or both. http://purl.obolibrary.org/obo/SYMP_0000435 paresthesia http://purl.obolibrary.org/obo/SYMP_0000488 skin and integumentary tissue symptom Paresthesia is a skin and integumentary tissue symptom characterized as a sensation of pricking, tingling, or creeping on the skin having no objective cause and usually associated with injury or irritation of a sensory nerve or nerve root. http://purl.obolibrary.org/obo/SYMP_0000450 shock http://purl.obolibrary.org/obo/SYMP_0000528 cardiovascular system symptom A cardiovascular system symptom that is characterized as a state of profound depression of the vital processes of the body that is characterized by pallor, rapid but weak pulse, rapid and shallow respiration, reduced total blood volume, and low blood pressure and that is caused usually by severe especially crushing injuries, hemorrhage, burns, or major surgery. http://purl.obolibrary.org/obo/SYMP_0000510 pallor http://purl.obolibrary.org/obo/SYMP_0000488 skin and integumentary tissue symptom Pallor is a skin and integumentary tissue symptom characterized as a deficiency of color especially of the face. http://purl.obolibrary.org/obo/SYMP_0000511 flushing http://purl.obolibrary.org/obo/SYMP_0000488 skin and integumentary tissue symptom Flushing is a skin and integumentary tissue symptom characterized as a markedly red flush in a persons face and often other areas of the skin, from various physiological conditions. Flushing is generally distinguished, despite a close physiological relation between them, from blushing, which is milder, generally restricted to the face or cheeks, and generally assumed to reflect embarrassment. Flushing is also a cardinal symptom of carcinoid syndrome the syndrome that results from hormones (often serotonin or histamine) being secreted into systemic circulation. http://purl.obolibrary.org/obo/SYMP_0000529 tachycardia http://purl.obolibrary.org/obo/SYMP_0000287 arrhythmia Tachycardia is a cardiovascular system symptom consisting of a relatively rapid heart action whether physiological (as after exercise) or pathological. http://purl.obolibrary.org/obo/SYMP_0000564 nocturia http://purl.obolibrary.org/obo/SYMP_0000486 urinary system symptom Nocturia is a urinary system symptom characterized by urination at night especially when excessive. http://purl.obolibrary.org/obo/SYMP_0000571 insomnia http://purl.obolibrary.org/obo/SYMP_0000566 sleep disturbance Insomnia is a sleep disturbance characterized by prolonged and usually abnormal inability to obtain adequate sleep. http://purl.obolibrary.org/obo/SYMP_0000582 hypersomnia http://purl.obolibrary.org/obo/SYMP_0000566 sleep disturbance Hypersomnia is a sleep disturbance characterized by sleeping for excessive periods at intervals with intervening periods of normal duration of sleeping and waking. http://purl.obolibrary.org/obo/SYMP_0000734 stroke https://bio.scai.fraunhofer.de/ontology/epilepsy#hypoxic-ischemic hypoxic-ischemic Stroke is a nervous system symptom characterized by a sudden diminution or loss of consciousness, sensation, and voluntary motion caused by rupture or obstruction (as by a clot) of a blood vessel of the brain. http://purl.obolibrary.org/obo/SYMP_0000834 hypoesthesia http://purl.obolibrary.org/obo/SYMP_0000892 sensation perception Hypoesthesia is a general symptom where there is a diminished sensitivity to stimulation. http://purl.obolibrary.org/obo/SYMP_0000837 chronic pain http://purl.obolibrary.org/obo/SYMP_0000099 pain Chronic pain is a pain that can range from mild to severe, and continues beyond the expected healing phase. http://purl.obolibrary.org/obo/SYMP_0000874 hematoma http://purl.obolibrary.org/obo/SYMP_0000488 skin and integumentary tissue symptom Hematoma is a skin and integumentary tissue symptom characterized by a mass of usually clotted blood that forms in a tissue, organ, or body space as a result of a broken blood vessel generally the result of hemorrhage, or more specifically, internal bleeding. http://purl.obolibrary.org/obo/SYMP_0019173 meningitis http://purl.obolibrary.org/obo/SYMP_0000480 nervous system symptom Meningitis is a nervous system symptom characterized as an inflammation of the meninges and especially of the pia mater and the arachnoid. http://purl.obolibrary.org/obo/SYMP_0019182 behavioral symptom http://purl.obolibrary.org/obo/SYMP_0000480 nervous system symptom A nervous system symptom that involves, is related to, or emphasizes behavior. http://purl.obolibrary.org/obo/SYMP_0019184 limited attention http://purl.obolibrary.org/obo/SYMP_0019182 behavioral symptom A behavioral symptom that is characterized by a restricted rate of information processing by the brain. http://purl.obolibrary.org/obo/HP_0025454 Abnormal CSF metabolite level http://purl.obolibrary.org/obo/HP_0002921 Abnormality of the cerebrospinal fluid Any deviation from the normal range of concentration of a metabolite in the cerebrospinal fluid. http://purl.obolibrary.org/obo/NCIT_C25347 Height http://purl.obolibrary.org/obo/NCIT_C19332 Personal Attribute The vertical measurement or distance from the base to the top of an object; the vertical dimension of extension. http://purl.obolibrary.org/obo/NCIT_C74739 Glutamate Measurement http://purl.obolibrary.org/obo/OBA_0000116 neurotransmitter levels The determination of the amount of glutamate present in a sample. http://purl.obolibrary.org/obo/NCIT_C74838 Acetylcholine Measurement http://purl.obolibrary.org/obo/NCIT_C74742 Hormone Measurement The determination of the amount of acetylcholine hormone present in a sample. http://purl.obolibrary.org/obo/DOID_0014667 disease of metabolism http://purl.obolibrary.org/obo/DOID_4 disease A disease that involving errors in metabolic processes of building or degradation of molecules. http://purl.obolibrary.org/obo/DOID_0050013 carbohydrate metabolism disease http://purl.obolibrary.org/obo/DOID_0060158 acquired metabolic disease An acquired metabolic disease that is characterized by abnormal carbohydrate metabolism. http://purl.obolibrary.org/obo/DOID_0050117 disease by infectious agent http://purl.obolibrary.org/obo/DOID_4 disease A disease that is the consequence of the presence of pathogenic microbial agents, including pathogenic viruses, pathogenic bacteria, fungi, protozoa, multicellular parasites, and aberrant proteins known as prions. http://purl.obolibrary.org/obo/DOID_0050155 sensory system disease http://purl.obolibrary.org/obo/DOID_863 nervous system disease A nervous system disease which is located in a part of the nervous system responsible for processing sensory information that consists of sensory receptors, neural pathways, and parts of the brain involved in sensory perception. Commonly recognized sensory systems are those for vision, hearing, somatic sensation (touch), taste and olfaction (smell). http://purl.obolibrary.org/obo/DOID_0050161 lower respiratory tract disease http://purl.obolibrary.org/obo/DOID_1579 respiratory system disease A respiratory system disease which involves the lower respiratory tract. http://purl.obolibrary.org/obo/DOID_0050177 monogenic disease http://purl.obolibrary.org/obo/DOID_630 genetic disease A genetic disease that is the result of one or more abnormal alleles and may be dominant, semi-dominant, or recessive. http://purl.obolibrary.org/obo/DOID_0050338 primary bacterial infectious disease http://purl.obolibrary.org/obo/DOID_104 bacterial infectious disease A bacterial infectious disease that results_in infection by bacteria as a result of their presence or activity within the normal, healthy host, and their intrinsic virulence is, in part, a necessary consequence of their need to reproduce and spread. http://purl.obolibrary.org/obo/DOID_0050425 restless legs syndrome http://purl.obolibrary.org/obo/DOID_331 central nervous system disease A central nervous system disease characterized by throbbing, pulling creeping or other unpleasant sensations in the legs and the irresistible urge to move them. http://purl.obolibrary.org/obo/DOID_0050451 Brugada syndrome http://purl.obolibrary.org/obo/DOID_10273 heart conduction disease A heart conduction disease that is characterized by abnormal electrocardiogram (ECG) findings and an increased risk of sudden cardiac death. http://purl.obolibrary.org/obo/DOID_0050453 lissencephaly http://purl.obolibrary.org/obo/NCIT_C84834 Malformations of Cortical Development A congenital nervous system abnormality characterized by the absence of folds in the cerebral cortex and caused_by defective neuronal migration during the 12th to 24th weeks of gestation. http://purl.obolibrary.org/obo/DOID_0050460 Wolf-Hirschhorn syndrome http://purl.obolibrary.org/obo/MONDO_0019040 chromosomal anomaly A chromosomal deletion syndrome that is characterized by distinct craniofacial features, hypotonia and intellectual disability and has_material_basis_in a microdeletion of the short arm of chromosome 4. http://purl.obolibrary.org/obo/DOID_0050561 Lennox-Gastaut syndrome http://purl.obolibrary.org/obo/MONDO_0020072 childhood-onset epilepsy syndrome A childhood electroclinical syndrome that is characterized by frequent seizures and intellectual disability that present in early childhood. http://purl.obolibrary.org/obo/DOID_0050562 West syndrome http://purl.obolibrary.org/obo/MONDO_0100022 neonatal/infantile epilepsy syndrome An infancy electroclinical syndrome that is characterized by infantile spasms, hypsarrhythmia on electroencephalogram and intellectual disability. http://purl.obolibrary.org/obo/DOID_0050589 inflammatory bowel disease http://purl.obolibrary.org/obo/DOID_5295 intestinal disease An intestinal disease characterized by inflammation located_in all parts of digestive tract. http://purl.obolibrary.org/obo/DOID_0050628 advanced sleep phase syndrome http://purl.obolibrary.org/obo/DOID_0050736 autosomal dominant disease A sleep disorder that involves an altered circadian rhythm resulting in falling asleep in early evening and awaking very early in the morning. http://purl.obolibrary.org/obo/DOID_0050635 alternating hemiplegia of childhood http://purl.obolibrary.org/obo/MONDO_0017657 rare paroxysmal movement disorder A hemiplegia characterized by recurrent episodes of temporary weakness or complete paralysis on one or both sides of the body. http://purl.obolibrary.org/obo/DOID_0050700 cardiomyopathy http://purl.obolibrary.org/obo/DOID_114 heart disease A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle. http://purl.obolibrary.org/obo/DOID_0050709 early infantile epileptic encephalopathy http://purl.obolibrary.org/obo/MONDO_0100022 neonatal/infantile epilepsy syndrome A neonatal period electroclinical syndrome that is characterized by tonic spasms and partial seizures. http://purl.obolibrary.org/obo/DOID_0050736 autosomal dominant disease http://purl.obolibrary.org/obo/DOID_0050739 autosomal genetic disease An autosomal genetic disease that is characterized by the presence of one disease-associated mutation of a gene which is sufficient to cause the disease. http://purl.obolibrary.org/obo/DOID_0050739 autosomal genetic disease http://purl.obolibrary.org/obo/DOID_0050177 monogenic disease A monogenic disease that has_material_basis_in a mutation in a single gene on one of the non-sex chromosomes. http://purl.obolibrary.org/obo/DOID_0050741 alcohol dependence http://purl.obolibrary.org/obo/DOID_9973 substance dependence A substance dependence that is characterized by tolerance, withdrawal symptoms, increasing use, persistent desire to decrease consumption, time spent obtaining or recovering from alcohol caused by a physical and psychological dependence on alcohol. http://purl.obolibrary.org/obo/DOID_0050742 nicotine dependence http://purl.obolibrary.org/obo/DOID_9973 substance dependence A substance dependence that is characterized by a physical dependence on nicotine. http://purl.obolibrary.org/obo/DOID_0050828 artery disease http://purl.obolibrary.org/obo/DOID_178 vascular disease A vascular disease that is located_in an artery. http://purl.obolibrary.org/obo/DOID_0050847 sleep apnea http://purl.obolibrary.org/obo/NBO_0000419 sleeping behavior phenotype A sleep disorder characterized by repeated cessation and commencing of breathing that repeatedly disrupts sleep. http://purl.obolibrary.org/obo/DOID_0050848 obstructive sleep apnea http://purl.obolibrary.org/obo/DOID_0050847 sleep apnea A sleep apnea that is characterized by repeated collapse and obstruction of the upper airway during sleep, which results in reduced airflow (hypopnea) or complete airflow cessation (apnea), oxygen desaturation, and arousals from sleep. http://purl.obolibrary.org/obo/DOID_0050951 hereditary ataxia http://purl.obolibrary.org/obo/DOID_1289 neurodegenerative disease A neurodegenerative disease that is characterized by slowly progressive incoordination of gait and often associated with poor coordination of hands, speech, and eye movements. http://purl.obolibrary.org/obo/DOID_0050989 episodic ataxia type 1 http://purl.obolibrary.org/obo/DOID_963 episodic ataxia An episodic ataxia that is characterized by periodic ataxia and frequent myokymic discharges, and has_material_basis_in autosomal dominant inheritance of mutation in the potassium channel gene KCNA1. http://purl.obolibrary.org/obo/DOID_0050990 episodic ataxia type 2 http://purl.obolibrary.org/obo/DOID_963 episodic ataxia An episodic ataxia that is characterized by periodic ataxia and nystagmus, and has_material_basis_in autosomal dominant inheritance of mutation in the calcium channel gene CACNA1A. http://purl.obolibrary.org/obo/DOID_0060004 autoimmune disease of central nervous system http://purl.obolibrary.org/obo/DOID_438 autoimmune disease of the nervous system An autoimmune hypersensitivity disease located_in the central nervous system. http://purl.obolibrary.org/obo/DOID_0060031 autoimmune disease of gastrointestinal tract http://purl.obolibrary.org/obo/DOID_417 autoimmune hypersensitivity disease An autoimmune hypersensitivity disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the gastrointestinal tract. http://purl.obolibrary.org/obo/DOID_0060032 autoimmune disease of musculoskeletal system http://purl.obolibrary.org/obo/DOID_417 autoimmune hypersensitivity disease An autoimmune hypersensitivity disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the musculoskeletal system. http://purl.obolibrary.org/obo/DOID_0060033 autoimmune disease of peripheral nervous system http://purl.obolibrary.org/obo/DOID_574 peripheral nervous system disease An autoimmune disease of the nervous system that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the peripheral nervous system. http://purl.obolibrary.org/obo/DOID_0060036 intrinsic cardiomyopathy http://purl.obolibrary.org/obo/DOID_0050700 cardiomyopathy A cardiomyopathy that is characterized as weakness in the muscle of the heart that is not due to an identifiable external cause. http://purl.obolibrary.org/obo/DOID_0060037 developmental disorder of mental health http://purl.obolibrary.org/obo/DOID_150 disease of mental health A disease of mental health that occur during a child's developmental period between birth and age 18 resulting in retarding of the child's psychological or physical development. http://purl.obolibrary.org/obo/DOID_0060038 specific developmental disorder http://purl.obolibrary.org/obo/DOID_0060037 developmental disorder of mental health A developmental disorder of mental health that categorizes specific learning disabilities and developmental disorders affecting coordination. http://purl.obolibrary.org/obo/DOID_0060039 autoimmune disease of skin and connective tissue http://purl.obolibrary.org/obo/DOID_1575 rheumatic disease An autoimmune hypersensitivity disease that is the abnormal functioning of the immune system that causes your immune system to produce antibodies or T cells against cells and/or tissues in the skin and connective tissue. http://purl.obolibrary.org/obo/DOID_0060040 pervasive developmental disorder http://purl.obolibrary.org/obo/DOID_0060037 developmental disorder of mental health A developmental disorder of mental health that refers to a group of five disorders characterized by impairments in socialization and communication, as well as restricted interests and repetitive behaviors. http://purl.obolibrary.org/obo/DOID_0060041 autism spectrum disorder http://purl.obolibrary.org/obo/DOID_0060040 pervasive developmental disorder A pervasive developmental disorder that is a spectrum of psychological conditions. The disease has_symptom widespread abnormalities of social interactions and communication, has_symptom severely restricted interests and has_symptom highly repetitive behavior. http://purl.obolibrary.org/obo/DOID_0060043 sexual disorder http://purl.obolibrary.org/obo/DOID_150 disease of mental health A disease of mental health that involves the impairment in normal sexual functioning. http://purl.obolibrary.org/obo/DOID_0060047 writing disorder http://purl.obolibrary.org/obo/DOID_8927 learning disability A learning disability that involves impaired written language ability such as impairments in handwriting, spelling, organization of ideas, and composition. http://purl.obolibrary.org/obo/DOID_0060056 hypersensitivity reaction disease http://purl.obolibrary.org/obo/DOID_2914 immune system disease An immune system disease that has_material_basis_in abnormal immune responses. http://purl.obolibrary.org/obo/DOID_0060072 benign neoplasm http://purl.obolibrary.org/obo/DOID_14566 disease of cellular proliferation A disease of cellular proliferation that results in abnormal growths in the body which lack the ability to metastasize. http://purl.obolibrary.org/obo/DOID_0060084 cell type benign neoplasm http://purl.obolibrary.org/obo/DOID_0060072 benign neoplasm A benign neoplasm that is classified by the type of cell or tissue from which it is derived. http://purl.obolibrary.org/obo/DOID_0060085 organ system benign neoplasm http://purl.obolibrary.org/obo/DOID_0060072 benign neoplasm A benign neoplasm that is classified by the organ system from which it is arising from. http://purl.obolibrary.org/obo/DOID_0060090 central nervous system benign neoplasm http://purl.obolibrary.org/obo/DOID_331 central nervous system disease A central nervous system benign neoplasm that is characterized by lack of malignancy. http://purl.obolibrary.org/obo/DOID_0060091 cardiovascular organ benign neoplasm http://purl.obolibrary.org/obo/DOID_1287 cardiovascular system disease An organ system benign neoplasm disease located_in the blood, heart, blood vessels or the lymphatic system. http://purl.obolibrary.org/obo/DOID_0060108 brain glioma http://purl.obolibrary.org/obo/MONDO_0021042 glioma A brain cancer that has_material_basis_in glial cells. http://purl.obolibrary.org/obo/DOID_0060115 nervous system benign neoplasm http://purl.obolibrary.org/obo/DOID_0060085 organ system benign neoplasm An organ system benign neoplasm that is located_in the central nervous system or located_in the peripheral nervous system. http://purl.obolibrary.org/obo/DOID_0060155 visual agnosia http://purl.obolibrary.org/obo/DOID_4090 agnosia An agnosia that is a loss of the ability to visually recognize objects. http://purl.obolibrary.org/obo/DOID_0060158 acquired metabolic disease http://purl.obolibrary.org/obo/DOID_0014667 disease of metabolism A disease of metabolism that has _material_basis_in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption. http://purl.obolibrary.org/obo/DOID_0060169 benign familial infantile epilepsy http://purl.obolibrary.org/obo/MONDO_0015654 idiopathic or cryptogenic familial epilepsy syndrome with identified loci/genes An infancy electroclinical syndrome that is characterized by convulsions, with onset at age 3 to 12 months. http://purl.obolibrary.org/obo/DOID_0060172 juvenile absence epilepsy http://purl.obolibrary.org/obo/MONDO_0100030 adolescent/adult-onset epilepsy syndrome An adolescence-adult electroclinical syndrome statring between the age of ten to 17 years characterized by the occurrence of typical absence seizures. http://purl.obolibrary.org/obo/DOID_0060178 familial hemiplegic migraine https://bio.scai.fraunhofer.de/ontology/epilepsy#migraine_associated_disorder migraine associated disorder A migraine with aura that is characterized by temporary numbness or weakness, often affecting one side of the body (hemiparesis). Additional features of an aura can include difficulty with speech, confusion, and drowsiness. http://purl.obolibrary.org/obo/DOID_0060244 specific language impairment http://purl.obolibrary.org/obo/DOID_93 language disorder A language disorder characterized by difficulty in language acquisition despite otherwise normal development and in the absence of any obvious explanatory factors. http://purl.obolibrary.org/obo/DOID_0060281 photosensitive epilepsy http://purl.obolibrary.org/obo/DOID_1826 epilepsy An epilepsy characterized by seizures triggered by visual stimuli that form patterns in space or time, such as flashing lights. http://purl.obolibrary.org/obo/DOID_0060319 cardiac arrest http://purl.obolibrary.org/obo/DOID_6000 congestive heart failure A congestive heart failure characterized by a sudden stop in effective blood circulation due to the failure of the heart to contract effectively or at all. http://purl.obolibrary.org/obo/DOID_0060326 myelomeningocele http://purl.obolibrary.org/obo/DOID_319 spinal cord disease A spina bifida characterized by protrusion of the spinal cord through an opening, covered by meningeal membranes. http://purl.obolibrary.org/obo/DOID_0060394 chromosome 15q13.3 microdeletion syndrome http://purl.obolibrary.org/obo/MONDO_0019040 chromosomal anomaly A chromosomal deletion syndrome that is characterized by intellectual dsability, developmental delay, autism spectrum disorder and seizure, has_material_basis_in autosomal dominant inheritance of partial deletion of the long arm of chromosome 15. http://purl.obolibrary.org/obo/DOID_0060469 Miller-Dieker lissencephaly syndrome http://purl.obolibrary.org/obo/MONDO_0019040 chromosomal anomaly A syndrome characterized by classical lissencephaly and distinct facial features and has_material_basis_in submicroscopic deletions of 17p13.3, including the LIS1 gene. http://purl.obolibrary.org/obo/DOID_0060500 drug allergy http://purl.obolibrary.org/obo/DOID_1205 allergic hypersensitivity disease A hypersensitivity reaction type I disease triggered by a drug. http://purl.obolibrary.org/obo/DOID_0060681 autosomal dominant nocturnal frontal lobe epilepsy http://purl.obolibrary.org/obo/MONDO_0020072 childhood-onset epilepsy syndrome A frontal lobe epilepsy that is characterized by autosomal dominant inheritance with childhood onset of clusters of brief nocturnal motor seizures with hyperkinetic or tonic manifestations. http://purl.obolibrary.org/obo/DOID_0080001 bone disease http://purl.obolibrary.org/obo/DOID_65 connective tissue disease A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function. http://purl.obolibrary.org/obo/DOID_0080015 physical disorder http://purl.obolibrary.org/obo/DOID_4 disease A disease that has_material_basis_in a genetic abnormality, error with embryonic development, infection or compromised intrauterine environment. http://purl.obolibrary.org/obo/DOID_0080122 mitochondrial DNA depletion syndrome 4a http://purl.obolibrary.org/obo/MONDO_0044970 mitochondrial disease A mitochondrial DNA depletion syndrome that is characterized by a clinical triad of psychomotor retardation, intractable epilepsy, and liver failure in infants and young children, and has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the nuclear gene encoding mitochondrial DNA polymerase gamma on chromosome 15q26. http://purl.obolibrary.org/obo/DOID_10024 migraine with aura https://bio.scai.fraunhofer.de/ontology/epilepsy#migraine_associated_disorder migraine associated disorder A migraine characterized by migraine headache which is preceded or accompanied by a transient focal neurological phenomenon. http://purl.obolibrary.org/obo/DOID_10079 cysticercosis http://purl.obolibrary.org/obo/DOID_331 central nervous system disease A taeniasis that results from ingestion of eggs or larvae of the Taenia solium tapeworm in undercooked pork or fecally contaminated food or water, which subsequently infect the central nervous system, heart, muscles, subcutaneous tissues, and eyes. Neurocysticercosis causes seizures, mental disturbances, focal neurologic deficits and intracerebral lesions. http://purl.obolibrary.org/obo/DOID_10112 sleeping sickness http://purl.obolibrary.org/obo/DOID_10113 trypanosomiasis A trypanosomiasis that results from infection by Trypanosoma brucei and gambiense, which is transmitted by the bite of an infected tsetse fly (Glossina spp). The symptoms include fever, headache, joint pain, itching, confusion, sensory disturbances, poor coordination and sleep disturbances. http://purl.obolibrary.org/obo/DOID_10113 trypanosomiasis http://purl.obolibrary.org/obo/DOID_0050117 disease by infectious agent A parasitic protozoa infectious disease that involves infection caused by parasitic protozoan of the genus Trypanosoma in animals and humans. http://purl.obolibrary.org/obo/DOID_10273 heart conduction disease http://purl.obolibrary.org/obo/DOID_114 heart disease A cardiovascular system disease that involves the heart's electrical conduction system. http://purl.obolibrary.org/obo/DOID_104 bacterial infectious disease http://purl.obolibrary.org/obo/DOID_0050117 disease by infectious agent A disease by infectious agent that results_in infection, has_material_basis_in Bacteria. http://purl.obolibrary.org/obo/DOID_1059 intellectual disability http://purl.obolibrary.org/obo/DOID_0060038 specific developmental disorder A specific developmental disorder that involves significant limitations both in mental functioning and in adaptive behavior such as communicating, taking care of him or herself, and social skills. http://purl.obolibrary.org/obo/DOID_10608 celiac disease http://purl.obolibrary.org/obo/DOID_0060031 autoimmune disease of gastrointestinal tract An autoimmune disease of gastrointestinal tract that is caused by a reaction located_in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has_symptom abdominal pain, has_symptom constipation, has_symptom diarrhea, has_symptom nausea and vomiting, and has_symptom loss of appetite. http://purl.obolibrary.org/obo/DOID_10652 Alzheimer's disease http://purl.obolibrary.org/obo/DOID_680 tauopathy A tauopathy that is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability and results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. http://purl.obolibrary.org/obo/DOID_1074 kidney failure http://purl.obolibrary.org/obo/DOID_557 kidney disease A kidney disease characterized by the failure of the kidneys to adequately filter waste products from the blood. http://purl.obolibrary.org/obo/DOID_10763 hypertension http://purl.obolibrary.org/obo/DOID_0050828 artery disease An artery disease characterized by chronic elevated blood pressure in the arteries. http://purl.obolibrary.org/obo/DOID_10914 amnestic disorder http://purl.obolibrary.org/obo/DOID_1561 cognitive disorder A cognitive disorder where the memory is disturbed or lost and involves the loss of memories previously established, loss of the ability to create new memories, or loss of the ability to learn new information. http://purl.obolibrary.org/obo/DOID_10933 obsessive-compulsive disorder http://purl.obolibrary.org/obo/DOID_2030 anxiety disorder An anxiety disorder that involves unwanted and repeated thoughts, feelings, ideas, sensations (obsessions), or behaviors that make them feel driven to do something (compulsions). http://purl.obolibrary.org/obo/DOID_10934 multiple personality disorder http://purl.obolibrary.org/obo/DOID_150 disease of mental health A dissociative disorder that involves the simultaneous display of multiple distinct identities or personalities. http://purl.obolibrary.org/obo/DOID_10935 dissociative disorder http://purl.obolibrary.org/obo/NCIT_C35470 Behavioral Disorder A disease of mental health in which the normally well-integrated functions of memory, identity, perception, or consciousness are separated (dissociated). http://purl.obolibrary.org/obo/DOID_1094 attention deficit hyperactivity disorder http://purl.obolibrary.org/obo/DOID_0060038 specific developmental disorder A specific developmental disorder that is characterized by co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone and symptoms starting before seven years of age. http://purl.obolibrary.org/obo/DOID_10969 hemiplegia http://purl.obolibrary.org/obo/DOID_331 central nervous system disease A central nervous system disease that is characterized by the complete paralysis of half of the body. http://purl.obolibrary.org/obo/DOID_11038 depersonalization disorder http://purl.obolibrary.org/obo/DOID_150 disease of mental health A dissociative disorder in which the sufferer is affected by persistent or recurrent feelings of depersonalization and/or derealization. http://purl.obolibrary.org/obo/DOID_11199 hypoparathyroidism http://purl.obolibrary.org/obo/DOID_11201 parathyroid gland disease A parathyroid gland disease characterized by decreased function of parathyroid glands with underproduction of parathyroid hormone (PTH), leading to abnormally low ionized calcium levels in the blood. http://purl.obolibrary.org/obo/DOID_11201 parathyroid gland disease http://purl.obolibrary.org/obo/DOID_28 endocrine system disease An endocrine system disease that is located_in the parathyroid gland. http://purl.obolibrary.org/obo/DOID_11257 social phobia http://purl.obolibrary.org/obo/DOID_591 phobic disorder A phobic disorder that involves social anxiety occurring only in specific public or social situations, interactions with others or being evaluated or scrutinized by other people. http://purl.obolibrary.org/obo/DOID_11294 arteriovenous malformation http://purl.obolibrary.org/obo/MONDO_0024291 vascular malformation A hemangioma that is characterized by a configuration of blood vessels that shunts arterial blood directly into veins by bypassing the capillary system. http://purl.obolibrary.org/obo/DOID_11335 sarcoidosis http://purl.obolibrary.org/obo/DOID_2916 hypersensitivity reaction type IV disease A hypersensitivity reaction type IV disease characterized by the growth of collections of inflammatory cells (granulomas) in multiple organs. http://purl.obolibrary.org/obo/DOID_114 heart disease http://purl.obolibrary.org/obo/DOID_1287 cardiovascular system disease A cardiovascular system disease that involves the heart. http://purl.obolibrary.org/obo/DOID_1176 bronchial disease http://purl.obolibrary.org/obo/DOID_0050161 lower respiratory tract disease A lower respiratory tract disease that affects the airways leading into the lungs, which is caused due to inflammation of the bronchi and bronchioles, infection, or blockage. http://purl.obolibrary.org/obo/DOID_1205 allergic hypersensitivity disease http://purl.obolibrary.org/obo/DOID_0060056 hypersensitivity reaction disease An immune system disease that is an exaggerated immune response to allergens, such as insect venom, dust mites, pollen, pet dander, drugs or some foods. http://purl.obolibrary.org/obo/DOID_12132 granulomatosis with polyangiitis http://purl.obolibrary.org/obo/DOID_850 lung disease An autoimmune hypersensitivity disease that is characterized by necrotizing granulomatous inflammation of the upper and lower respiratory tract, glomerulonephritis, vasculitis, and the presence of antineutrophil cytoplasmatic autoantibodies (ANCAs) in patient sera, and is located_in lung, located_in kidney, located_in skin resulting from an autoimmune attack by antineutrophil cytoplasmic antibodies against small and medium-size blood vessels. http://purl.obolibrary.org/obo/DOID_12568 dyscalculia http://purl.obolibrary.org/obo/DOID_8927 learning disability A learning disability involving a math disability can cause such difficulties as learning math concepts (such as quantity, place value, and time), difficulty memorizing math facts, difficulty organizing numbers, and understanding how problems are organized on the page. http://purl.obolibrary.org/obo/DOID_1287 cardiovascular system disease http://purl.obolibrary.org/obo/DOID_7 disease of anatomical entity A disease of anatomical entity which occurs in the blood, heart, blood vessels or the lymphatic system that passes nutrients (such as amino acids and electrolytes), gases, hormones, blood cells or lymph to and from cells in the body to help fight diseases and help stabilize body temperature and pH to maintain homeostasis. http://purl.obolibrary.org/obo/DOID_1289 neurodegenerative disease http://purl.obolibrary.org/obo/DOID_331 central nervous system disease A central nervous system disease that results in the progressive deterioration of function or structure of neurons. http://purl.obolibrary.org/obo/DOID_12894 Sjogren's syndrome http://purl.obolibrary.org/obo/DOID_417 autoimmune hypersensitivity disease An autoimmune hypersensitivity disease that involves attack of immune cells which destroy the exocrine glands that produce tears and saliva. http://purl.obolibrary.org/obo/DOID_13027 transient global amnesia http://purl.obolibrary.org/obo/DOID_10914 amnestic disorder An amnestic disorder that is characterized by temporary but almost total disruption of short-term memory with a range of problems accessing older memories. http://purl.obolibrary.org/obo/DOID_1307 dementia http://purl.obolibrary.org/obo/DOID_1561 cognitive disorder A cognitive disorder resulting from a loss of brain function affecting memory, thinking, language, judgement and behavior. http://purl.obolibrary.org/obo/DOID_13148 acute cystitis http://purl.obolibrary.org/obo/DOID_1679 cystitis A cystitis characterized by a sudden onset or severe symptoms. http://purl.obolibrary.org/obo/DOID_1319 brain cancer http://purl.obolibrary.org/obo/DOID_936 brain disease A central nervous system cancer that is characterized by the growth of abnormal cells in the tissues of the brain. http://purl.obolibrary.org/obo/DOID_13268 porphyria http://purl.obolibrary.org/obo/DOID_655 inherited metabolic disorder An inherited metabolic disorder that involves certain enzymes in the heme bio-synthetic pathway resulting in the overproduction and accumulation of the porphyrins. http://purl.obolibrary.org/obo/DOID_13317 hyperinsulinemic hypoglycemia http://purl.obolibrary.org/obo/DOID_2978 carbohydrate metabolic disorder A carbohydrate metabolic disorder that involves low blood glucose resulting from an excess of insulin. http://purl.obolibrary.org/obo/DOID_13365 reading disorder http://purl.obolibrary.org/obo/DOID_8927 learning disability A learning disability involing difficulty reading resulting primarily from neurological factors which affect any part of the reading process. http://purl.obolibrary.org/obo/DOID_13515 tuberous sclerosis http://purl.obolibrary.org/obo/NCIT_C84834 Malformations of Cortical Development A syndrome that is characterized by the growth of numerous noncancerous tumors in many parts of the body. http://purl.obolibrary.org/obo/DOID_14069 cerebral malaria https://bio.scai.fraunhofer.de/ontology/epilepsy#infectious_etiology infectious etiology A malaria that involves neurologic damage resulting from blockage of the blood vessels, caused due to the infection of the red blood cells by Plasmodium species. http://purl.obolibrary.org/obo/DOID_14250 Down syndrome http://purl.obolibrary.org/obo/MONDO_0019040 chromosomal anomaly A chromosomal disease that is characterized by flat-looking facial features and weak muscle tone (hypotonia) in infancy and is caused by trisomy of all or a critical portion of chromosome 21 and is associated with intellectual disability. http://purl.obolibrary.org/obo/DOID_14504 Niemann-Pick disease http://purl.obolibrary.org/obo/DOID_1927 sphingolipidosis A sphingoliidosis characterized by the accumulation of the lipid sphingomyelin in lysosomes in cells. http://purl.obolibrary.org/obo/DOID_14566 disease of cellular proliferation http://purl.obolibrary.org/obo/DOID_4 disease A disease that is characterized by abnormally rapid cell division. http://purl.obolibrary.org/obo/DOID_150 disease of mental health http://purl.obolibrary.org/obo/DOID_4 disease A disease that involves a psychological or behavioral pattern generally associated with subjective distress or disability that occurs in an individual, and which are not a part of normal development or culture. http://purl.obolibrary.org/obo/DOID_1510 personality disorder http://purl.obolibrary.org/obo/DOID_150 disease of mental health A disease of mental health that involve long-term patterns of thoughts and behaviors that cause serious problems with relationships and work. http://purl.obolibrary.org/obo/DOID_1561 cognitive disorder http://purl.obolibrary.org/obo/DOID_150 disease of mental health A disease of mental health that affects cognitive functions including memory processing, perception and problem solving. http://purl.obolibrary.org/obo/DOID_1564 fungal infectious disease http://purl.obolibrary.org/obo/DOID_0050117 disease by infectious agent A disease by infectious agent that results_in infection, has_material_basis_in Fungi, which pass the resistance barriers of the human or animal body. http://purl.obolibrary.org/obo/DOID_1574 alcohol use disorder http://purl.obolibrary.org/obo/DOID_302 substance abuse A substance abuse that involves the recurring use of alcoholic beverages despite negative consequences. http://purl.obolibrary.org/obo/DOID_1575 rheumatic disease http://purl.obolibrary.org/obo/DOID_65 connective tissue disease An autoimmune hypersensitivity disease that involves inflammation or pain in the muscles, joints, or fibrous tissue. http://purl.obolibrary.org/obo/DOID_1579 respiratory system disease http://purl.obolibrary.org/obo/DOID_7 disease of anatomical entity A disease of anatomical entity that located_in the respiratory system which extends from the nasal sinuses to the diaphragm. http://purl.obolibrary.org/obo/DOID_16 integumentary system disease http://purl.obolibrary.org/obo/DOID_7 disease of anatomical entity A disease of anatomical entity that is located_in the integumentary system comprising the skin and its appendages. http://purl.obolibrary.org/obo/DOID_1679 cystitis http://purl.obolibrary.org/obo/DOID_365 bladder disease A bladder disease that is characterized by inflammation of the bladder. http://purl.obolibrary.org/obo/DOID_17 musculoskeletal system disease http://purl.obolibrary.org/obo/DOID_7 disease of anatomical entity A disease of anatomical entity that occurs in the muscular and/or skeletal system. http://purl.obolibrary.org/obo/DOID_1766 factitious disorder http://purl.obolibrary.org/obo/NCIT_C35470 Behavioral Disorder A disease of mental health where symptoms are deliberately produced, feigned or exaggerated in order to falsely demonstrate the presence of an illness. http://purl.obolibrary.org/obo/DOID_178 vascular disease http://purl.obolibrary.org/obo/DOID_1287 cardiovascular system disease A cardiovascular system disease that primarily affects the blood vessels which includes the arteries, veins and capillaries that carry blood to and from the heart. http://purl.obolibrary.org/obo/DOID_18 urinary system disease http://purl.obolibrary.org/obo/DOID_7 disease of anatomical entity A disease of anatomical entity that is located_in kidney, ureter, bladder and urethra. http://purl.obolibrary.org/obo/DOID_1826 epilepsy http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions. http://purl.obolibrary.org/obo/DOID_1827 idiopathic generalized epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#epilepsy_classification epilepsy classification An epilepsy syndrome that is characterised by generalised seizures with no apparent cause which arise from many independent foci (multifocal epilepsies) or from epileptic circuits that involve the whole brain. http://purl.obolibrary.org/obo/DOID_1891 optic nerve disease http://purl.obolibrary.org/obo/DOID_5656 cranial nerve disease A cranial nerve disease that is located_in the optic nerve. http://purl.obolibrary.org/obo/DOID_1927 sphingolipidosis http://purl.obolibrary.org/obo/DOID_9455 lipid storage disease A lipid storage disease characterized by functional deficiencies in the enzymes needed for lysosomal degradation of sphingolipid substrates. http://purl.obolibrary.org/obo/DOID_1969 cerebral palsy http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is caused by damage to the motor control centers of the developing brain during pregnancy, during childbirth or after birth, which affects muscle movement and balance. http://purl.obolibrary.org/obo/DOID_2030 anxiety disorder http://purl.obolibrary.org/obo/DOID_1561 cognitive disorder A cognitive disorder that involves an excessive, irrational dread of everyday situations. http://purl.obolibrary.org/obo/DOID_2033 communication disorder http://purl.obolibrary.org/obo/DOID_0060038 specific developmental disorder A specific developmental disorder that involves specific developmental disorders of speech and language. http://purl.obolibrary.org/obo/DOID_2234 focal epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#epilepsy_classification epilepsy classification An epilepsy syndrome that is characterised by seizures that are preceded by an isolated disturbance of a cerebral function and arise from an epileptic focus, a small portion of the brain that serves as the irritant driving the epileptic response. http://purl.obolibrary.org/obo/DOID_224 transient cerebral ischemia http://purl.obolibrary.org/obo/DOID_2316 brain ischemia A brain ischemia that is characterized by ischemia of brief duration and without resultant tissue death. http://purl.obolibrary.org/obo/DOID_225 syndrome http://purl.obolibrary.org/obo/DOID_4 disease A disease characterized by a group of signs and symptoms that occur together and characterize a particular abnormality. http://purl.obolibrary.org/obo/DOID_2377 multiple sclerosis http://purl.obolibrary.org/obo/DOID_3213 demyelinating disease A demyelinating disease that involves damage to the fatty myelin sheaths around the axons of the brain and spinal cord resulting in demyelination and scarring. http://purl.obolibrary.org/obo/DOID_2468 psychotic disorder http://purl.obolibrary.org/obo/DOID_1561 cognitive disorder A cognitive disorder that involves abnormal thinking and perceptions resulting in a disconnection with reality. http://purl.obolibrary.org/obo/DOID_255 hemangioma http://purl.obolibrary.org/obo/DOID_0060091 cardiovascular organ benign neoplasm A cardiovascular organ benign neoplasm that has_material_basis_in endothelial cells that line blood vessels and is characterised by increased number of normal or abnormal vessels filled with blood. http://purl.obolibrary.org/obo/DOID_26 pancreas disease http://purl.obolibrary.org/obo/DOID_28 endocrine system disease An endocrine system disease that is located_in the pancreas. http://purl.obolibrary.org/obo/DOID_28 endocrine system disease http://purl.obolibrary.org/obo/DOID_7 disease of anatomical entity A disease of anatomical entity that is located_in endocrine glands which secretes a type of hormone directly into the bloodstream to regulate the body. http://purl.obolibrary.org/obo/DOID_2841 asthma http://purl.obolibrary.org/obo/DOID_1176 bronchial disease A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety. http://purl.obolibrary.org/obo/DOID_2843 long QT syndrome http://purl.obolibrary.org/obo/HP_0001279 Syncope An autosomal genetic disease that is characterized by delayed repolarization of the heart following a heartbeat increases the risk of episodes of torsade de pointes (TDP, a form of irregular heartbeat that originates from the ventricles). http://purl.obolibrary.org/obo/DOID_2914 immune system disease http://purl.obolibrary.org/obo/DOID_7 disease of anatomical entity A disease of anatomical entity that is located_in the immune system. http://purl.obolibrary.org/obo/DOID_2916 hypersensitivity reaction type IV disease http://purl.obolibrary.org/obo/DOID_0060056 hypersensitivity reaction disease A hypersensitivity reaction disease that is characterized by a cell-mediated response to antigens, where Th1 helper T cells react with antigens on antigen-presenting cells and cause a delayed type immune response. http://purl.obolibrary.org/obo/DOID_2978 carbohydrate metabolic disorder http://purl.obolibrary.org/obo/DOID_655 inherited metabolic disorder An inherited metabolic disorder that affect the catabolism and anabolism of carbohydrates. http://purl.obolibrary.org/obo/DOID_302 substance abuse http://purl.obolibrary.org/obo/DOID_303 substance-related disorder A substance-related disorder that involves a maladaptive pattern of substance use leading to significant impairment in functioning. http://purl.obolibrary.org/obo/DOID_303 substance-related disorder http://purl.obolibrary.org/obo/DOID_150 disease of mental health A disease of mental health involving the abuse or dependence on a substance that is ingested in order to produce a high, alter one's senses, or otherwise affect functioning. http://purl.obolibrary.org/obo/DOID_3068 glioblastoma multiforme http://purl.obolibrary.org/obo/DOID_3069 astrocytoma An astrocytoma characterized by the presence of small areas of necrotizing tissue that is surrounded by anaplastic cells as well as the presence of hyperplastic blood vessels, and that has_material_basis_in abnormally proliferating cells derives_from multiple cell types including astrocytes and oligondroctyes. http://purl.obolibrary.org/obo/DOID_3133 acute porphyria http://purl.obolibrary.org/obo/DOID_13268 porphyria A porphyria that has_symptom abdominal pain, has_symptom neuropathy, has_symptom autonomic instability and has_symptom psychosis. http://purl.obolibrary.org/obo/DOID_3211 lysosomal storage disease http://purl.obolibrary.org/obo/DOID_655 inherited metabolic disorder An inherited metabolic disorder that involve an abnormal accumulation of substances inside the lysosome resulting from defects in lysosomal function. http://purl.obolibrary.org/obo/DOID_3213 demyelinating disease http://purl.obolibrary.org/obo/DOID_1289 neurodegenerative disease A neurodegenerative disease that is characterized by damage to the myelin sheath present around nerve axons. http://purl.obolibrary.org/obo/DOID_326 ischemia http://purl.obolibrary.org/obo/DOID_178 vascular disease A vascular disease that is characterized by a restriction in blood supply to tissues. http://purl.obolibrary.org/obo/DOID_331 central nervous system disease http://purl.obolibrary.org/obo/DOID_863 nervous system disease A nervous system disease that affects either the spinal cord (myelopathy) or brain (encephalopathy) of the central nervous system. http://purl.obolibrary.org/obo/DOID_3312 bipolar disorder http://purl.obolibrary.org/obo/DOID_3324 mood disorder A mood disorder that involves alternating periods of mania and depression. http://purl.obolibrary.org/obo/DOID_3324 mood disorder http://purl.obolibrary.org/obo/DOID_1561 cognitive disorder A cognitive disorder that involves a disturbance in mood as the predominant underlying feature. http://purl.obolibrary.org/obo/DOID_3342 bone inflammation disease http://purl.obolibrary.org/obo/DOID_0080001 bone disease A bone disease that results_in inflammation of the located_in bone. http://purl.obolibrary.org/obo/DOID_3393 coronary artery disease http://purl.obolibrary.org/obo/DOID_0050828 artery disease An artery disease that is characterized by plaque building up along the inner walls of the arteries of the heart resulting in a narrowing of the arteries and a reduced blood supply to the cardiac muscles. http://purl.obolibrary.org/obo/DOID_3565 meningioma http://purl.obolibrary.org/obo/DOID_3620 central nervous system cancer A central nervous system cancer that are manifested in the central nervous system and arise from the arachnoid cap cells of the arachnoid villi in the meninges. http://purl.obolibrary.org/obo/DOID_3620 central nervous system cancer http://purl.obolibrary.org/obo/DOID_331 central nervous system disease A nervous system cancer that is located_in the central nervous system. http://purl.obolibrary.org/obo/DOID_365 bladder disease http://purl.obolibrary.org/obo/DOID_18 urinary system disease A urinary system disease that is located_in the bladder. http://purl.obolibrary.org/obo/DOID_37 skin disease http://purl.obolibrary.org/obo/DOID_16 integumentary system disease An integumentary system disease that is located_in skin. http://purl.obolibrary.org/obo/DOID_399 tuberculosis https://bio.scai.fraunhofer.de/ontology/epilepsy#infectious_etiology infectious etiology A primary bacterial infectious disease that is located_in lungs, located_in lymph nodes, located_in pericardium, located_in brain, located_in pleura or located_in gastrointestinal tract, has_material_basis_in Mycobacterium tuberculosis, which is transmitted_by droplets released into the air when an infected person coughs or sneezes. http://purl.obolibrary.org/obo/DOID_4 disease http://purl.obolibrary.org/obo/BFO_0000016 disposition A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism. http://purl.obolibrary.org/obo/DOID_4090 agnosia http://purl.obolibrary.org/obo/DOID_2033 communication disorder A communication disorder that is a loss of ability to recognize objects, persons, sounds, shapes, or smells while the specific sense is not defective nor is there any significant memory loss. http://purl.obolibrary.org/obo/DOID_417 autoimmune hypersensitivity disease http://purl.obolibrary.org/obo/DOID_0060056 hypersensitivity reaction disease An immune system disease that is an overactive immune response of the body against substances and tissues normally present in the body resulting from an abnormal functioning of the immune system that results in the production of antibodies or T cell directed against the host tissues. http://purl.obolibrary.org/obo/DOID_437 myasthenia gravis http://purl.obolibrary.org/obo/DOID_438 autoimmune disease of the nervous system An autoimmune disease of the nervous system that has_material_basis_in antibodies to acetylcholine receptors at the neuromuscular junction, has_symptom ptosis, has_symptom diplopia, has_symptom dysphagia, has_symptom dysarthria, has_symptom muscle weakness and has_symptom dyspnea. http://purl.obolibrary.org/obo/DOID_438 autoimmune disease of the nervous system http://purl.obolibrary.org/obo/DOID_417 autoimmune hypersensitivity disease An autoimmune hypersensitivity disease affecting the nervous system. http://purl.obolibrary.org/obo/DOID_4737 somatoform disorder http://purl.obolibrary.org/obo/DOID_150 disease of mental health A disease of mental health that involves physical symptoms suggesting a physical illness where the biological or medical cause of the symptoms is indeterminate. http://purl.obolibrary.org/obo/DOID_480 movement disease http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is characterized by a clinical syndrome of either hyperkinetic movement or hyperkinetic movement unrelated to weakness or spasticity. http://purl.obolibrary.org/obo/DOID_50 thyroid gland disease http://purl.obolibrary.org/obo/DOID_28 endocrine system disease An endocrine system disease that is located_in the thyroid. http://purl.obolibrary.org/obo/DOID_5113 nutritional deficiency disease http://purl.obolibrary.org/obo/DOID_374 nutrition disease A nutrition disease that is characterized by deficiency of a nutritional element, such as a vitamin, mineral, carbohydrate, protein, fat, or general energy content. http://purl.obolibrary.org/obo/DOID_5295 intestinal disease http://purl.obolibrary.org/obo/DOID_77 gastrointestinal system disease A gastrointestinal system disease that is located_in the intestine. http://purl.obolibrary.org/obo/DOID_535 sleep disorder https://bio.scai.fraunhofer.de/ontology/epilepsy#epilepsy_imitator epilepsy imitator A disease of mental health that involves disruption of sleep patterns. http://purl.obolibrary.org/obo/DOID_5419 schizophrenia http://purl.obolibrary.org/obo/DOID_2468 psychotic disorder A psychotic disorder that is characterized by a disintegration of thought processes and of emotional responsiveness. http://purl.obolibrary.org/obo/DOID_557 kidney disease http://purl.obolibrary.org/obo/DOID_18 urinary system disease A urinary system disease that is located_in the kidney. http://purl.obolibrary.org/obo/DOID_5614 eye disease http://purl.obolibrary.org/obo/DOID_0050155 sensory system disease An eye and adnexa disease that is located_in the eye. http://purl.obolibrary.org/obo/DOID_5656 cranial nerve disease http://purl.obolibrary.org/obo/DOID_870 neuropathy A neuropathy that is located_in one of the twelve cranial nerves. http://purl.obolibrary.org/obo/DOID_574 peripheral nervous system disease http://purl.obolibrary.org/obo/DOID_863 nervous system disease A nervous system disease that affects the peripheral nervous system. http://purl.obolibrary.org/obo/DOID_591 phobic disorder http://purl.obolibrary.org/obo/DOID_2030 anxiety disorder An anxiety disorder where fear and anxiety are triggered by a specific stimulus or situation. http://purl.obolibrary.org/obo/DOID_6000 congestive heart failure http://purl.obolibrary.org/obo/DOID_114 heart disease A heart disease that is characterized by any structural or functional cardiac disorder that impairs the ability of the heart to fill with or pump a sufficient amount of blood throughout the body. http://purl.obolibrary.org/obo/DOID_630 genetic disease http://purl.obolibrary.org/obo/DOID_4 disease A disease that has_material_basis_in genetic variations in the human genome. http://purl.obolibrary.org/obo/DOID_6364 migraine http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is characterized by moderate to severe headaches, nausea, extreme sensitivity to light and sound and intense unilaterial throbbing or pulsing. http://purl.obolibrary.org/obo/DOID_646 viral encephalitis https://bio.scai.fraunhofer.de/ontology/epilepsy#infectious_etiology infectious etiology An encephalitis that involves inflammation of the brain caused by viral infection. http://purl.obolibrary.org/obo/DOID_65 connective tissue disease http://purl.obolibrary.org/obo/DOID_17 musculoskeletal system disease A musculoskeletal system disease that affects tissues such as skin, tendons, and cartilage. http://purl.obolibrary.org/obo/DOID_654 overnutrition http://purl.obolibrary.org/obo/DOID_374 nutrition disease A nutrition disease that is characterized by an excess of a nutritional element, such as a vitamin, mineral, carbohydrate, protein, fat, or general energy content. http://purl.obolibrary.org/obo/DOID_655 inherited metabolic disorder http://purl.obolibrary.org/obo/DOID_630 genetic disease A disease of metabolism that is characterized by enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to inherited enzyme abnormality. http://purl.obolibrary.org/obo/DOID_6713 cerebrovascular disease http://purl.obolibrary.org/obo/DOID_936 brain disease An vascular disease that is characterized by dysfunction of the blood vessels supplying the brain. http://purl.obolibrary.org/obo/DOID_680 tauopathy http://purl.obolibrary.org/obo/DOID_1289 neurodegenerative disease A neurodegenerative disease that has_material_basis_in the pathological aggregation of tau protein in so-called neurofibrillary tangles (NFT) in the human brain. http://purl.obolibrary.org/obo/DOID_7 disease of anatomical entity http://purl.obolibrary.org/obo/DOID_4 disease A disease that manifests in a defined anatomical structure. http://purl.obolibrary.org/obo/DOID_77 gastrointestinal system disease http://purl.obolibrary.org/obo/DOID_7 disease of anatomical entity A disease of anatomical entity that is located_in the gastrointestinal tract. http://purl.obolibrary.org/obo/DOID_7998 hyperthyroidism http://purl.obolibrary.org/obo/DOID_50 thyroid gland disease A thyroid gland disease that involves an over production of thyroid hormone. http://purl.obolibrary.org/obo/DOID_848 arthritis http://purl.obolibrary.org/obo/DOID_3342 bone inflammation disease A bone inflammation disease that involves a response to irritation or injury, characterized by joint pain, swelling, stiffness located_in joint and/or redness located_in skin over the joint. http://purl.obolibrary.org/obo/DOID_850 lung disease http://purl.obolibrary.org/obo/DOID_0050161 lower respiratory tract disease A lower respiratory tract disease in which the function of the lungs is adversely affected by narrowing or blockage of the airways resulting in poor air flow, a loss of elasticity in the lungs that produces a decrease in the total volume of air that the lungs are able to hold, and clotting, scarring, or inflammation of the blood vessels that affect the ability of the lungs to take up oxygen and to release carbon dioxide. http://purl.obolibrary.org/obo/DOID_863 nervous system disease http://purl.obolibrary.org/obo/DOID_7 disease of anatomical entity A disease of anatomical entity that is located_in the central nervous system or located_in the peripheral nervous system. http://purl.obolibrary.org/obo/DOID_870 neuropathy http://purl.obolibrary.org/obo/DOID_574 peripheral nervous system disease A nervous system disease that is located_in nerves or nerve cells. http://purl.obolibrary.org/obo/DOID_8778 Crohn's disease http://purl.obolibrary.org/obo/DOID_0050589 inflammatory bowel disease An intestinal disease that involves inflammation located_in intestine. http://purl.obolibrary.org/obo/DOID_8857 lupus erythematosus http://purl.obolibrary.org/obo/DOID_417 autoimmune hypersensitivity disease An autoimmune hypersensitivity disease that is characterized by a constellation of findings that include elevated antibodies to nuclear antigens, antiphospholipids, low complement levels, ulcers, non-scarring alopecia, renal or neurologic damage, and low white blood cell and platelet counts, has_symptom rashes, fatigue, arthritis, hair loss, seizures, and symptoms related to affected organs, and has_material_basis_in autoimmune disorder. http://purl.obolibrary.org/obo/DOID_8927 learning disability http://purl.obolibrary.org/obo/DOID_0060038 specific developmental disorder A specific developmental disorder that involves difficulty in scholastic skills such as reading, writing, spelling, reasoning, recalling and/or organizing information resulting from the brain's inability to receive and process information. http://purl.obolibrary.org/obo/DOID_906 peroxisomal disease https://bio.scai.fraunhofer.de/ontology/epilepsy#metabolic_etiology metabolic etiology An inherited metabolic disorder that involves peroxisome malfunction. http://purl.obolibrary.org/obo/DOID_9252 amino acid metabolic disorder http://purl.obolibrary.org/obo/DOID_655 inherited metabolic disorder An inherited metabolic disorder that is characterized by impaired synthesis and degradation of amino acids. http://purl.obolibrary.org/obo/DOID_93 language disorder http://purl.obolibrary.org/obo/DOID_2033 communication disorder A communication disorder that involves the processing of linguistic information. http://purl.obolibrary.org/obo/DOID_934 viral infectious disease http://purl.obolibrary.org/obo/DOID_0050117 disease by infectious agent A disease by infectious agent that results in infection, has_material_basis_in Viruses. http://purl.obolibrary.org/obo/DOID_9351 diabetes mellitus http://purl.obolibrary.org/obo/DOID_4194 glucose metabolism disease A glucose metabolism disease characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. http://purl.obolibrary.org/obo/DOID_936 brain disease http://purl.obolibrary.org/obo/DOID_331 central nervous system disease A central nervous system disease that is located_in the brain. http://purl.obolibrary.org/obo/DOID_9428 intracranial hypertension http://purl.obolibrary.org/obo/NCIT_C69023 Miscellaneous A brain disease that is characterized by high pressure inside the skull, the brain tissue and cerebrospinal fluid, has_symptom headache, has_symptom vomiting, has_symptom altered mental status, has_symptom papilledema. http://purl.obolibrary.org/obo/DOID_9455 lipid storage disease http://purl.obolibrary.org/obo/DOID_3211 lysosomal storage disease A lysosomal storage disease that involves the accumulation of harmful amounts of lipids (fats) in some of the body's cells and tissues. http://purl.obolibrary.org/obo/DOID_9588 encephalitis http://purl.obolibrary.org/obo/DOID_936 brain disease A brain disease that is characterized as an acute inflammation of the brain with flu-like symptoms. http://purl.obolibrary.org/obo/DOID_963 episodic ataxia http://purl.obolibrary.org/obo/MONDO_0017657 rare paroxysmal movement disorder A hereditary ataxia characterized by sporadic bouts of ataxia with or without continuous muscle movement. http://purl.obolibrary.org/obo/DOID_9744 type 1 diabetes mellitus http://purl.obolibrary.org/obo/DOID_9351 diabetes mellitus A diabetes mellitus that results from the body's failure to produce insulin and has_material_basis_in autoimmune destruction of insulin-producing beta cells of the pancreas. http://purl.obolibrary.org/obo/DOID_9970 obesity http://purl.obolibrary.org/obo/DOID_654 overnutrition An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. http://purl.obolibrary.org/obo/DOID_9973 substance dependence http://purl.obolibrary.org/obo/DOID_303 substance-related disorder A substance-related disorder that involves the continued use of alcohol or other drugs despite problems related to use of the substance. http://purl.obolibrary.org/obo/HP_0000271 Abnormality of the face http://purl.obolibrary.org/obo/HP_0000234 Abnormality of the head An abnormality of the face. http://purl.obolibrary.org/obo/HP_0000365 Hearing impairment http://purl.obolibrary.org/obo/HP_0000364 Hearing abnormality A decreased magnitude of the sensory perception of sound. http://purl.obolibrary.org/obo/HP_0000707 Abnormality of the nervous system http://purl.obolibrary.org/obo/HP_0000118 Phenotypic abnormality An abnormality of the nervous system. http://purl.obolibrary.org/obo/HP_0000924 Abnormality of the skeletal system http://purl.obolibrary.org/obo/HP_0000118 Phenotypic abnormality An abnormality of the skeletal system. http://purl.obolibrary.org/obo/HP_0001269 Hemiparesis http://purl.obolibrary.org/obo/HP_0004374 Hemiplegia/hemiparesis Loss of strength in the arm, leg, and sometimes face on one side of the body. Hemiplegia refers to a complete loss of strength, whereas hemiparesis refers to an incomplete loss of strength. http://purl.obolibrary.org/obo/HP_0001276 Hypertonia http://purl.obolibrary.org/obo/HP_0003808 Abnormal muscle tone A condition in which there is increased muscle tone so that arms or legs, for example, are stiff and difficult to move. http://purl.obolibrary.org/obo/HP_0001977 Abnormal thrombosis http://purl.obolibrary.org/obo/HP_0001871 Abnormality of blood and blood-forming tissues Venous or arterial thrombosis (formation of blood clots) of spontaneous nature and which cannot be fully explained by acquired risk (e.g. atherosclerosis). http://purl.obolibrary.org/obo/HP_0002069 Generalized tonic-clonic seizures https://bio.scai.fraunhofer.de/ontology/epilepsy#generalized_motor_onset_seizure generalized motor onset seizure Generalized tonic-clonic seizures are generalized seizures with bilateral symmetrical tonic contraction then bilateral clonic contractions of somatic muscles usually associated with autonomic phenomena. http://purl.obolibrary.org/obo/HP_0002329 Drowsiness http://purl.obolibrary.org/obo/HP_0004372 Reduced consciousness/confusion Excessive daytime sleepiness. http://purl.obolibrary.org/obo/HP_0002615 Hypotension http://purl.obolibrary.org/obo/HP_0030972 Abnormal systemic blood pressure Low Blood Pressure, vascular hypotension. http://purl.obolibrary.org/obo/HP_0011029 Internal hemorrhage http://purl.obolibrary.org/obo/HP_0011028 Abnormality of blood circulation The presence of hemorrhage within the body. http://purl.obolibrary.org/obo/UBERON_0000955 brain http://purl.obolibrary.org/obo/UBERON_0000062 organ The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]. http://purl.obolibrary.org/obo/UBERON_0001872 parietal lobe http://purl.obolibrary.org/obo/UBERON_0016526 lobe of cerebral hemisphere Upper central part of the cerebral hemisphere. (MSH) http://purl.obolibrary.org/obo/UBERON_0002298 brainstem http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain Stalk-like part of the brain that includes amongst its parts the medulla oblongata of the hindbrain and the tegmentum of the midbrain[ZFA,MP,generalized]. http://purl.obolibrary.org/obo/UBERON_0002336 corpus callosum http://purl.obolibrary.org/obo/UBERON_0005340 dorsal telencephalic commissure White matter structure containing massive numbers of commissural fibers connecting cortical areas in the two cerebral hemispheres.it is subdivided into a genu, a rostrum, a body, and a splenium. (MM) http://purl.obolibrary.org/obo/UBERON_0016525 frontal lobe http://purl.obolibrary.org/obo/UBERON_0016526 lobe of cerebral hemisphere Frontal lobe is the anterior-most of five lobes of the cerebral hemisphere. It is bounded by the central sulcus on its posterior border and by the longitudinal cerebral fissure on its medial border. http://purl.obolibrary.org/obo/UBERON_0035014 functional part of brain http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain A brain region defined by functional criteria, e.g. auditory cortex, rather than by structural or histological criteria. http://purl.obolibrary.org/obo/MFOEM_000001 emotion process http://purl.obolibrary.org/obo/MFOEM_000195 affective process An emotion process is a complex mental process that is a synchronized aggregate of constituent mental processes including an appraisal process as part, and which gives rise to an action tendency. http://purl.obolibrary.org/obo/MFOEM_000009 anger http://purl.obolibrary.org/obo/MFOEM_000001 emotion process Anger is a negative emotion, characterised by feelings of unpleasantness and high arousal, in the form of antagonistic feelings and action tendencies. [Source: OCEAS] http://purl.obolibrary.org/obo/MFOEM_000026 fear http://purl.obolibrary.org/obo/MFOEM_000001 emotion process An activated, aversive emotion that motivates attempts to cope with events that provide threats to the survival or well-being of organisms. Characterised by feelings of threat and impending doom, and by an urge to get out of the situation. [Source: OCEAS] http://purl.obolibrary.org/obo/MFOEM_000034 joy http://purl.obolibrary.org/obo/MFOEM_000042 happiness A pleasant, positive emotion which arises in safe and familiar circumstances, when people have made progress towards important personal goals, especially when the progress is better than expected. [Source: OCEAS] http://purl.obolibrary.org/obo/MFOEM_000042 happiness http://purl.obolibrary.org/obo/MFOEM_000001 emotion process A positive emotion which is experienced in reaction to a positive experience or event. [Source: OCEAS] http://purl.obolibrary.org/obo/MFOEM_000056 sadness http://purl.obolibrary.org/obo/MFOEM_000001 emotion process A negative emotion felt when an event is appraised as unpleasant, obstructive to one's goals and concerns, and one feels unable to cope with it or modify it. [Source: OCEAS] http://purl.obolibrary.org/obo/MFOEM_000195 affective process http://purl.obolibrary.org/obo/MF_0000020 mental process An affective process is any process that has positive or negative valence. http://purl.obolibrary.org/obo/SYMP_0019152 diaphoresis http://purl.obolibrary.org/obo/SYMP_0019175 sweaty Diaphoresis is a sweat characterized as excessive sweating commonly associated with shock and other medical emergency conditions. http://purl.obolibrary.org/obo/NCIT_C50726 Regurgitation http://purl.obolibrary.org/obo/SYMP_0000459 digestive system symptom Flow in the opposite direction from normal, as the casting up of undigested food or gas from the stomach, or the backward flowing of blood into the heart, or between the chambers of the heart when a valve is incompetent. http://purl.obolibrary.org/obo/MONDO_0020071 infantile epilepsy syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A epilepsy syndrome that occurs between 28 days to one year of life.. http://purl.obolibrary.org/obo/GO_0006936 muscle contraction http://purl.obolibrary.org/obo/GO_0003012 muscle system process A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. http://purl.obolibrary.org/obo/GO_0007613 memory http://purl.obolibrary.org/obo/MF_0000033 mental disposition The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task). http://purl.obolibrary.org/obo/GO_0048609 multicellular organismal reproductive process http://purl.obolibrary.org/obo/GO_0022414 reproductive process The process, occurring above the cellular level, that is pertinent to the reproductive function of a multicellular organism. This includes the integrated processes at the level of tissues and organs. http://purl.obolibrary.org/obo/HP_0005294 Arterial dissection http://purl.obolibrary.org/obo/HP_0011004 Abnormal systemic arterial morphology A separation (dissection) of the layers of an artery. http://purl.obolibrary.org/obo/HP_0007206 Hemimegalencephaly http://purl.obolibrary.org/obo/NCIT_C84834 Malformations of Cortical Development Enlargement of all or parts of one cerebral hemisphere. http://purl.obolibrary.org/obo/HP_0010531 Spinal myoclonus http://purl.obolibrary.org/obo/NCIT_C69023 Miscellaneous Spinal myoclonus is generally due to a tumor, infection, injury, or degenerative process of the spinal cord, and is characterized by involuntary rhythmic muscle contractions, usually at a rate of more than one per second. Myoclonus occurs synchronously in several muscles and can be increased in severity and frequency by fatigue or stress, but is usually unaffected by sensory stimuli. Spinal myoclonus ceases during sleep or anesthesia. http://purl.obolibrary.org/obo/HP_0010636 Schizencephaly http://purl.obolibrary.org/obo/NCIT_C84834 Malformations of Cortical Development The presence of a cleft in the cerebral cortex unilaterally or bilaterally, usually located in the frontal area. http://purl.obolibrary.org/obo/HP_0010677 Enuresis nocturna http://purl.obolibrary.org/obo/HP_0000805 Enuresis Enuresis occurring during sleeping hours. http://purl.obolibrary.org/obo/HP_0010818 Generalized tonic seizures https://bio.scai.fraunhofer.de/ontology/epilepsy#generalized_motor_onset_seizure generalized motor onset seizure Generalized seizures with sustained increase in muscle contraction lasting a few seconds to minutes. http://purl.obolibrary.org/obo/HP_0010819 Atonic seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#generalized_motor_onset_seizure generalized motor onset seizure Atonic seizure is a type of motor seizure characterized by a sudden loss or diminution of muscle tone without apparent preceding myoclonic or tonic event lasting about 1 to 2 seconds, involving head, trunk, jaw, or limb musculature. http://purl.obolibrary.org/obo/HP_0010820 Dacrystic seizures http://purl.obolibrary.org/obo/HP_0025613 Focal emotional seizure A type of seizure characterized by crying or an outburst of crying as a major feature. http://purl.obolibrary.org/obo/HP_0010821 Gelastic seizures http://purl.obolibrary.org/obo/HP_0025613 Focal emotional seizure A type of seizure characterized by laughing or an outburst of laughing as a major feature. http://purl.obolibrary.org/obo/HP_0010845 EEG with generalized slow activity http://purl.obolibrary.org/obo/HP_0011203 EEG with abnormally slow frequencies Diffuse slowing of cerebral electrical activity recorded along the scalp by electroencephalography (EEG). http://purl.obolibrary.org/obo/HP_0010847 EEG with spike-wave complexes (<2.5 Hz) http://purl.obolibrary.org/obo/HP_0010850 EEG with spike-wave complexes The presence of complexes of slow spikes and slow waves (<2.5 Hz) in electroencephalography (EEG). http://purl.obolibrary.org/obo/HP_0010852 EEG with photoparoxysmal response http://purl.obolibrary.org/obo/HP_0002353 EEG abnormality EEG abnormalities (epileptiform discharges) evoked by flashing lights or black and white striped patterns. http://purl.obolibrary.org/obo/HP_0010853 EEG with periodic lateralized epileptiform discharges http://purl.obolibrary.org/obo/HP_0011186 Focal epileptiform discharges with limited propagation to contralateral hemisphere Periodic lateralized epileptiform discharges (PLEDs)are periodic, lateralized, and epileptiform. PLEDs show a relatively constant interval between discharges (0.5 to 3 seconds). http://purl.obolibrary.org/obo/HP_0010927 Abnormal blood inorganic cation concentration http://purl.obolibrary.org/obo/HP_0010929 Abnormal blood cation concentration An abnormality of divalent inorganic cation homeostasis. http://purl.obolibrary.org/obo/HP_0010929 Abnormal blood cation concentration http://purl.obolibrary.org/obo/HP_0003111 Abnormal blood ion concentration An abnormality of cation homeostasis. http://purl.obolibrary.org/obo/HP_0010930 Abnormal blood monovalent inorganic cation concentration http://purl.obolibrary.org/obo/HP_0010929 Abnormal blood cation concentration An abnormality of monovalent inorganic cation homeostasis. http://purl.obolibrary.org/obo/HP_0011024 Abnormality of the gastrointestinal tract http://purl.obolibrary.org/obo/HP_0025031 Abnormality of the digestive system An abnormality of the gastrointestinal tract. http://purl.obolibrary.org/obo/HP_0011028 Abnormality of blood circulation http://purl.obolibrary.org/obo/HP_0011025 Abnormal cardiovascular system physiology An abnormality of blood circulation. http://purl.obolibrary.org/obo/HP_0011097 Epileptic spasms https://bio.scai.fraunhofer.de/ontology/epilepsy#generalized_motor_onset_seizure generalized motor onset seizure A sudden flexion, extension or mixed extension-flexion of predominantly proximal and truncal muscles which is usually more sustained than a myoclonic movement but not as sustained as a tonic seizure. http://purl.obolibrary.org/obo/HP_0011149 Absence seizure with eyelid myoclonia https://bio.scai.fraunhofer.de/ontology/epilepsy#generalized_non-motor_onset_seizure generalized non-motor onset seizure Absence seizures accompanied by brief, repetitive, often rhythmic, fast (4-6 Hz) myoclonic jerks of the eyelids with simultaneous upward deviation of the eyeballs and extension of the head. Seizures are typically very brief (less than 6s in duration) and multiple seizures occur on a daily basis. Mostly awareness is retained. http://purl.obolibrary.org/obo/HP_0011150 Myoclonic absence https://bio.scai.fraunhofer.de/ontology/epilepsy#generalized_non-motor_onset_seizure generalized non-motor onset seizure Rhythmic myoclonic jerks of the shoulders and arms with tonic abduction that results in progressive lifting of the arms during the seizure. The myoclonic jerks are typically bilateral but may be unilateral or asymmetric. Perioral myoclonias and rhythmic jerks of the head and legs may occur. Seizures last 10-60 seconds and typically occur daily. Level of awareness varies from complete loss of awareness to retained awareness. http://purl.obolibrary.org/obo/HP_0011154 Focal autonomic seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_non-motor_onset_seizure focal non-motor onset seizure Focal seizures with an objectively documented and distinct alteration of autonomic nervous system function involving cardiovascular, pupillary, gastrointestinal, sudomotor, vasomotor and thermoregularity functions. http://purl.obolibrary.org/obo/HP_0011157 Focal sensory seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_non-motor_onset_seizure focal non-motor onset seizure A focal sensory seizure involves a sensation being experienced at seizure onset, without objective clinical signs of a seizure evident to the observer. http://purl.obolibrary.org/obo/HP_0011158 Focal sensory auditory seizure http://purl.obolibrary.org/obo/HP_0011157 Focal sensory seizure A type of focal sensory seizure that is characterized by elementary auditory phenomena including buzzing, ringing, drumming or single tones. http://purl.obolibrary.org/obo/HP_0011159 Epigastric auras http://purl.obolibrary.org/obo/SYMP_0000124 seizure Auras with abdominal discomfort including nausea, emptiness, tightness, churning, butterflies, malaise, pain, and hunger; sensation may rise to chest or throat. Some phenomena may reflect ictal autonomic dysfunction. http://purl.obolibrary.org/obo/HP_0011160 Focal sensory gustatory seizure http://purl.obolibrary.org/obo/HP_0011157 Focal sensory seizure Auras with taste sensations including acidic, bitter, salty , sweet or metallic tastes. http://purl.obolibrary.org/obo/HP_0011161 Olfactory auras http://purl.obolibrary.org/obo/HP_0011157 Focal sensory seizure Auras with sensation of odor, usually disagreeable. http://purl.obolibrary.org/obo/HP_0011162 Psychic auras http://purl.obolibrary.org/obo/SYMP_0000124 seizure Auras with affective, mnemonic or composite perceptual phenomena including illusory or composite hallucinatory events. http://purl.obolibrary.org/obo/HP_0011163 Somatosensory auras http://purl.obolibrary.org/obo/HP_0011157 Focal sensory seizure Auras with sensation of tingling, numbness, electric shock sensations, pain, sense of movement, or desire to move. http://purl.obolibrary.org/obo/HP_0011164 Vegetative auras http://purl.obolibrary.org/obo/SYMP_0000124 seizure A sensation consistent with involvement of the autonomic nervous system, including cardiovascular, gastrointestinal, sudomotor, vasomotor and thermoregulatory functions. http://purl.obolibrary.org/obo/HP_0011165 Visual auras http://purl.obolibrary.org/obo/HP_0011157 Focal sensory seizure Auras with sensation of flashing or flickering lights, spots, simple patterns, scotomata, or amaurosis. http://purl.obolibrary.org/obo/HP_0011167 Focal tonic seizures http://purl.obolibrary.org/obo/HP_0011153 Focal motor seizure Seizures with sustained increase in muscle contraction in parts of the body lasting a few seconds to minutes. http://purl.obolibrary.org/obo/HP_0011174 Hyperkinetic seizures http://purl.obolibrary.org/obo/HP_0011153 Focal motor seizure Seizures with increase in rate of ongoing movements or inappropriately rapid performance of a movement involving predominantly proximal limb or axial muscles producing irregular sequential ballistic movements, such as pedaling, pelvic thrashing, rocking movements. http://purl.obolibrary.org/obo/HP_0011175 Versive seizures http://purl.obolibrary.org/obo/SYMP_0000124 seizure Tonic seizures with a sustained, forced conjugate ocular, cephalic and/or truncal rotation or lateral deviation from the midline. http://purl.obolibrary.org/obo/HP_0011182 Interictal epileptiform activity http://purl.obolibrary.org/obo/HP_0025373 Interictal EEG abnormality Epileptiform activity refers to distinctive EEG waves or complexes distinguished from background activity found in in a proportion of human subjects with epilepsy, but which can also be found in subjects without seizures. Interictal epileptiform activity refers to such activity that occurs in the absence of a clinical or subclinical seizure. http://purl.obolibrary.org/obo/HP_0011185 EEG with focal epileptiform discharges http://purl.obolibrary.org/obo/HP_0011182 Interictal epileptiform activity EEG discharges recorded in particular areas of a localized (focal) abnormality in cerebral electrical activity recorded along the scalp by electroencephalography (EEG). http://purl.obolibrary.org/obo/HP_0011186 Focal epileptiform discharges with limited propagation to contralateral hemisphere http://purl.obolibrary.org/obo/HP_0011185 EEG with focal epileptiform discharges Focal epileptiform discharges with spreading to contralateral hemisphere but without secondary generalization. http://purl.obolibrary.org/obo/HP_0011203 EEG with abnormally slow frequencies http://purl.obolibrary.org/obo/HP_0002353 EEG abnormality EEG with abnormally slow frequencies. http://purl.obolibrary.org/obo/HP_0011204 EEG with continuous slow activity http://purl.obolibrary.org/obo/HP_0010845 EEG with generalized slow activity EEG showing diffuse slowing without interruption. http://purl.obolibrary.org/obo/HP_0011205 EEG with intermittent slow activity http://purl.obolibrary.org/obo/HP_0010845 EEG with generalized slow activity Non-continuous diffuse slowing of electroencephalographic patterns. http://purl.obolibrary.org/obo/HP_0012000 EEG with generalized spikes http://purl.obolibrary.org/obo/HP_0011198 EEG with generalized epileptiform discharges EEG with generalized sharp transient waves of a duration less than 80 msec. http://purl.obolibrary.org/obo/HP_0012001 EEG with generalized polyspikes http://purl.obolibrary.org/obo/HP_0011198 EEG with generalized epileptiform discharges EEG with repetitive generalized sharp transient waves of a duration less than 80 msec. http://purl.obolibrary.org/obo/HP_0012002 Experiential auras http://purl.obolibrary.org/obo/SYMP_0000124 seizure Affective, mnemonic or composite perceptual auras with subjective qualities similar to those experienced in life but are recognized by the subject as occurring outside of actual context. http://purl.obolibrary.org/obo/HP_0012004 Mnemonic auras http://purl.obolibrary.org/obo/HP_0012002 Experiential auras Auras which reflect ictal dysmnesia such as: feelings as familiarity (deja-vu) and unfamiliarity (jamais-vu). http://purl.obolibrary.org/obo/HP_0012005 Deja vu http://purl.obolibrary.org/obo/HP_0012004 Mnemonic auras A subjective feeling that an experience which is occurring for the first time has been experienced before. http://purl.obolibrary.org/obo/HP_0012006 Jamais vu http://purl.obolibrary.org/obo/HP_0012004 Mnemonic auras A subjective feeling that an experience which has occurred before is being experienced for the first time. http://purl.obolibrary.org/obo/HP_0012377 Hemianopia http://purl.obolibrary.org/obo/HP_0001123 Visual field defect Partial or complete loss of vision in one half of the visual field of one or both eyes. http://purl.obolibrary.org/obo/HP_0012415 Abnormal blood gas level http://purl.obolibrary.org/obo/HP_0002795 Functional respiratory abnormality An abnormality of the partial pressure of oxygen or carbon dioxide in the arterial blood. http://purl.obolibrary.org/obo/HP_0012418 Hypoxemia http://purl.obolibrary.org/obo/HP_0500165 Abnormal blood oxygen level An abnormally low level of blood oxygen. http://purl.obolibrary.org/obo/HP_0012508 Metamorphopsia http://purl.obolibrary.org/obo/HP_0000504 Abnormality of vision A visual anomaly in which images appear distorted. A grid of straight lines appears wavy and parts of the grid may appear blank. http://purl.obolibrary.org/obo/HP_0100033 Tics http://purl.obolibrary.org/obo/MONDO_0017657 rare paroxysmal movement disorder Repeated, individually recognizable, intermittent movements or movement fragments that are almost always briefly suppresable and are usually associated with awareness of an urge to perform the movement. http://purl.obolibrary.org/obo/HP_0100261 Abnormal tendon morphology http://purl.obolibrary.org/obo/HP_0011842 Abnormality of skeletal morphology An abnormality of the structure or form of the tendons, also often called sinews. http://purl.obolibrary.org/obo/HP_0100310 Epidural hemorrhage http://purl.obolibrary.org/obo/HP_0002170 Intracranial hemorrhage Hemorrhage occurring between the dura mater and the skull. http://purl.obolibrary.org/obo/HP_0100576 Amaurosis fugax http://purl.obolibrary.org/obo/HP_0000504 Abnormality of vision A transient visual disturbance that is typically caused by a circulatory, ocular or neurological underlying condition. http://purl.obolibrary.org/obo/HP_0100770 Hyperperistalsis http://purl.obolibrary.org/obo/HP_0030914 Abnormal peristalsis Excessively active peristalsis (wave of contraction of the tubular organs of the gastrointestinal tract) marked by excessive rapidity of the passage of food through the stomach and intestine. http://purl.obolibrary.org/obo/HP_0100771 Hypoperistalsis http://purl.obolibrary.org/obo/HP_0030914 Abnormal peristalsis Reduced or inadequate peristalsis, with resultant slow passage of contents through the digestive tract. http://purl.obolibrary.org/obo/HP_0100832 Vitreous floaters http://purl.obolibrary.org/obo/HP_0004327 Abnormal vitreous humor morphology Deposits of various size, shape, consistency, refractive index, and motility within the eye's vitreous humour, which is normally transparent. http://purl.obolibrary.org/obo/UBERON_0000052 fornix of brain http://purl.obolibrary.org/obo/UBERON_0007702 tract of brain A C-shaped bundle of fibres (axons) in the brain, and carries signals from the hippocampus to the mammillary bodies and septal nuclei. It is typically divided into the columns (crus), body, commissure and the pre-commissural and post-commissural fornix (MM). http://purl.obolibrary.org/obo/UBERON_0000055 vessel http://purl.obolibrary.org/obo/UBERON_0004111 anatomical conduit A tubular structure that contains, conveys body fluid, such as blood or lymph. http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure http://purl.obolibrary.org/obo/UBERON_0000465 material anatomical entity Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome. http://purl.obolibrary.org/obo/UBERON_0000062 organ http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure Anatomical structure that performs a specific function or group of functions [WP]. http://purl.obolibrary.org/obo/UBERON_0000064 organ part http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure A multicellular structure that is a part of an organ. http://purl.obolibrary.org/obo/UBERON_0000073 regional part of nervous system http://purl.obolibrary.org/obo/UBERON_0000481 multi-tissue structure Any part or collection of parts of the central or peripheral nervous system. Parts may span both CNS and PNS. http://purl.obolibrary.org/obo/UBERON_0000093 sulcus http://purl.obolibrary.org/obo/UBERON_0000464 anatomical space A depression or fissure in the surface of an organ. http://purl.obolibrary.org/obo/UBERON_0000119 cell layer http://purl.obolibrary.org/obo/UBERON_0000957 lamina Portion of tissue, that consists of single layer of cells connected to each other by cell junctions. Examples: layer of glial cells; epithelium. http://purl.obolibrary.org/obo/UBERON_0000122 neuron projection bundle http://purl.obolibrary.org/obo/UBERON_0005162 multi cell part structure A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses. http://purl.obolibrary.org/obo/UBERON_0000125 neural nucleus http://purl.obolibrary.org/obo/UBERON_0011215 central nervous system cell part cluster A spatially aggregated collection of nerve cell bodies in the CNS, consisting of one or more subpopulations that share cell type, chemical phenotype, and connections, and including nearby cells that share the same cell type, chemical phenotype, and connections. (CUMBO) http://purl.obolibrary.org/obo/UBERON_0000200 gyrus http://purl.obolibrary.org/obo/UBERON_0034768 morphological feature A ridge on the cerebral cortex. It is generally surrounded by one or more sulci . http://purl.obolibrary.org/obo/UBERON_0000344 mucosa http://purl.obolibrary.org/obo/UBERON_0004923 organ component layer A lining of mostly endodermal origin, covered in epithelium, which is involved in absorption and secretion. They line various body cavities that are exposed to the external environment and internal organs. It is at several places continuous with skin: at the nostrils, the lips, the ears, the genital area, and the anus. The sticky, thick fluid secreted by the mucous membranes and gland is termed mucus. The term mucous membrane refers to where they are found in the body and not every mucous membrane secretes mucus[WP] http://purl.obolibrary.org/obo/UBERON_0000446 septum of telencephalon http://purl.obolibrary.org/obo/UBERON_0005401 cerebral hemisphere gray matter Gray matter structure located on the midline of the forebrain consisting of the septum pellucidum (in some species) and the septal nuclei (Heimer, 1996). http://purl.obolibrary.org/obo/UBERON_0000451 prefrontal cortex http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain The anterior part of the frontal lobes of the brain, lying in front of the motor and premotor areas.nnThis brain region has been implicated in planning complex cognitive behaviors, personality expression, decision making and moderating correct social behavior. The basic activity of this brain region is considered to be orchestration of thoughts and actions in accordance with internal goals.nnThe most typical psychological term for functions carried out by the pre-frontal cortex area is executive function. Executive function relates to abilities to differentiate among conflicting thoughts, determine good and bad, better and best, same and different, future consequences of current activities, working toward a defined goal, prediction of outcomes, expectation based on actions, and social 'control' (the ability to suppress urges that, if not suppressed, could lead to socially-unacceptable outcomes).nnMany authors have indicated an integral link between a person's personality and the functions of the prefrontal cortex. - definition adapted from Wikipedia http://purl.obolibrary.org/obo/UBERON_0000454 cerebral subcortex http://purl.obolibrary.org/obo/UBERON_0000064 organ part The layer located below the cerebral cortex that includes the forebrain, midbrain and hindbrain. http://purl.obolibrary.org/obo/UBERON_0000464 anatomical space http://purl.obolibrary.org/obo/UBERON_0000466 immaterial anatomical entity Non-material anatomical entity of three dimensions, that is generated by morphogenetic or other physiologic processes; is surrounded by one or more anatomical structures; contains one or more organism substances or anatomical structures. http://purl.obolibrary.org/obo/UBERON_0000465 material anatomical entity http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity Anatomical entity that has mass. http://purl.obolibrary.org/obo/UBERON_0000466 immaterial anatomical entity http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity Anatomical entity that has no mass. http://purl.obolibrary.org/obo/UBERON_0000477 anatomical cluster http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity Anatomical group that has its parts adjacent to one another. http://purl.obolibrary.org/obo/UBERON_0000479 tissue http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure Multicellular anatomical structure that consists of many cells of one or a few types, arranged in an extracellular matrix such that their long-range organisation is at least partly a repetition of their short-range organisation. http://purl.obolibrary.org/obo/UBERON_0000481 multi-tissue structure http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure Anatomical structure that has as its parts two or more portions of tissue of at least two different types and which through specific morphogenetic processes forms a single distinct structural unit demarcated by bona-fide boundaries from other distinct structural units of different types. http://purl.obolibrary.org/obo/UBERON_0000956 cerebral cortex http://purl.obolibrary.org/obo/UBERON_0016548 central nervous system gray matter layer The thin layer of gray matter on the surface of the cerebral hemisphere that develops from the telencephalon. It consists of the neocortex (6 layered cortex or isocortex), the hippocampal formation and the olfactory cortex. http://purl.obolibrary.org/obo/UBERON_0000957 lamina http://purl.obolibrary.org/obo/UBERON_0000479 tissue Any thin layer or plate. http://purl.obolibrary.org/obo/UBERON_0000988 pons http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain The part of the central nervous system lying between the medulla oblongata and the midbrain, ventral to the cerebellum. http://purl.obolibrary.org/obo/UBERON_0001018 axon tract http://purl.obolibrary.org/obo/UBERON_0011215 central nervous system cell part cluster A group of axons linking two or more neuropils and having a common origin, termination[FBbt]. http://purl.obolibrary.org/obo/UBERON_0001020 nervous system commissure http://purl.obolibrary.org/obo/UBERON_0001018 axon tract Axon tract that crosses the midline of the central nervous system[NIF, modified]. In the context of Drosophila refers to a broad band of axons connecting equivalent neuropils each side of the brain[FBbt]. http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity http://purl.obolibrary.org/obo/BFO_0000040 material entity Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. http://purl.obolibrary.org/obo/UBERON_0001384 primary motor cortex http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain The part of the cerebral cortex that receives projections from the motor thalamus and which projects to motor neurons in the brainstem and spinal cord. The motor cortex corresponds to Brodmann's area 4 (MM). The primary motor cortex, or M1, is located on the precentral gyrus and on the anterior paracentral lobule on the medial surface of the brain. Of the three motor cortex areas, stimulation of the primary motor cortex requires the least amount of electrical current to elicit a movement. http://neuroscience.uth.tmc.edu/s3/chapter03.html http://purl.obolibrary.org/obo/UBERON_0001876 amygdala http://purl.obolibrary.org/obo/UBERON_0005401 cerebral hemisphere gray matter Subcortical brain region lying anterior to the hippocampal formation in the temporal lobe and anterior to the temporal horn of the lateral ventricle in some species. It is usually subdivided into several groups. Functionally, it is not considered a unitary structure (MM). http://purl.obolibrary.org/obo/UBERON_0001890 forebrain http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain The most anterior region the brain including both the telencephalon and diencephalon. http://purl.obolibrary.org/obo/UBERON_0001891 midbrain http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)[GO]. http://purl.obolibrary.org/obo/UBERON_0001896 medulla oblongata http://purl.obolibrary.org/obo/UBERON_0000064 organ part Organ component of neuraxis that has as its parts the medullary reticular formation, inferior olivary complex and cochlear nuclear complex, among other structures[FMA]. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate[GO]. http://purl.obolibrary.org/obo/UBERON_0001897 dorsal plus ventral thalamus http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain Subcortical brain region consisting of paired gray matter bodies in the dorsal diencephalon and forming part of the lateral wall of the third ventricle of the brain. The thalamus represents the major portion of the diencephalon and is commonly divided into cellular aggregates known as nuclear groups.(MeSH). The dorsal topographic division of the interbrain. The macrodissected adult human thalamus was clearly illustrated by Vesalius in 1543 and the term as defined here was introduced by His in 1893. It includes the traditional epithalamus, dorsal thalamus, and ventral thalamus of Herrick (1910, pp. 494, 498). Also see Kuhlenbeck (1927, Ch. 9) and Jones (1985, p. 87). http://purl.obolibrary.org/obo/UBERON_0001898 hypothalamus http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain A specialized brain region of the ventral diencephalon arising near the end of the segmentation period; the embryonic hypothalamic region will give rise to the posterior pituitary gland as well as a number of brain nuclei. [ZFA]. One of the most important functions of the hypothalamus is to link the nervous system to the endocrine system via the pituitary gland (hypophysis).[Wikipedia]. http://purl.obolibrary.org/obo/UBERON_0001945 superior colliculus http://purl.obolibrary.org/obo/UBERON_0006794 visual processing part of nervous system Part of the midbrain tecturm consisting of paired bodies that sit caudal to the thalamus and surround the pineal gland in the mesencephalon of vertebrate brains. It comprises the rostral aspect of the midbrain, posterior to the periaqueductal gray and adjacent superior the inferior colliculus. The inferior and superior colliculi are known collectively as the corpora quadrigemina (Latin, quadruplet bodies). It consists of several identified cellular layers and also comprises the brachium of the superior colliculus and commissure of supeior colliculus from Wikipedia.org and Neuronames (MM). http://purl.obolibrary.org/obo/UBERON_0001946 inferior colliculus http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain Part of the midbrain tectum, consisting of paired predominantly gray matter elevations on the dorsal aspect of the midbrain, located caudal to the superior colliculus, dorsal to the periaqueductal gray of the cerebral aqueduct and rostral to the cerebellum. According to Neuronames, the inferior colliculus comprises the central, pericentral and external nucleus and two predominantly white matter structures, the brachium of the inferior colliculus and the commissure of the inferior colliculus (MM). http://purl.obolibrary.org/obo/UBERON_0002020 gray matter http://purl.obolibrary.org/obo/UBERON_0011215 central nervous system cell part cluster A nervous system structure composed primarily of nerve cell bodies (somas). May also include dendrites and the initial unmyelinated portion of axons. http://purl.obolibrary.org/obo/UBERON_0002028 hindbrain http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain The most posterior of the three principal regions of the brain. In mammals and birds the hindbrain is divided into a rostral metencephalon and a caudal myelencephalon. In zebrafish, with the exception of the cerebellum, the ventral remainder of the metencephalon can be separated only arbitrarily from the more caudal myelencephalic portion of the medulla oblongata (From: Neuroanatomy of the Zebrafish Brain)[ZFA]. Organ component of neuraxis that has as its parts the pons, cerebellum and medulla oblongata[FMA]. http://purl.obolibrary.org/obo/UBERON_0002264 olfactory bulb http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain A bulbous anterior projection of the olfactory lobe that is the place of termination of the olfactory nerves and is especially well developed in lower vertebrates (as fishes)[BTO]. http://purl.obolibrary.org/obo/UBERON_0002308 nucleus of brain http://purl.obolibrary.org/obo/UBERON_0000125 neural nucleus A neural nucleus that is part of the brain. http://purl.obolibrary.org/obo/UBERON_0002314 midbrain tectum http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain Dorsal part of the midbrain, consisting of the superior and inferior colliculi and the pretectal nuclei (MM). http://purl.obolibrary.org/obo/UBERON_0002316 white matter http://purl.obolibrary.org/obo/UBERON_0011215 central nervous system cell part cluster Neural tissue consisting of myelinated axons connecting grey matter areas of the central nervous system. http://purl.obolibrary.org/obo/UBERON_0002422 fourth ventricle http://purl.obolibrary.org/obo/UBERON_0004086 brain ventricle Part of the ventricular system of the brain, forming a single large irregularly shaped cavity located on the midline of the rhombencephalon, between the medulla, pons and the isthmus ventrally and the cerebellum dorsally. It is continuous with the cerebral aqueduct anteriorally and the central canal of the spinal cord posteriorly. It communicates with the subarachnoid space through its lateral and median apertures. http://purl.obolibrary.org/obo/UBERON_0002436 primary visual cortex http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area A subdivision of the cytoarchitecturally defined occipital region of cerebral cortex in the human. Defined by the band of Gennari, which gives it the name striate (furrowed) area, it occupies the banks of the calcarine sulcus which are located in the cuneus and the lingual gyrus of the occipital lobe. Cytoarchitecturally it is bounded by the area 18 of Brodmann (human) which surrounds it ( Brodmann-1909 ). In the mouse ( Paxinos-2001 ) and the rat ( Swanson-1998 ) it is located on the dorsolateral surface of the cerebral hemisphere[BrainInfo]. http://purl.obolibrary.org/obo/UBERON_0002473 intercerebral commissure http://purl.obolibrary.org/obo/UBERON_0019294 commissure of telencephalon A commissure that connects the two cerebral hemispheres. Examples: anterior commissure, corpus callosum. http://purl.obolibrary.org/obo/UBERON_0002562 superior frontal sulcus http://purl.obolibrary.org/obo/UBERON_0013118 sulcus of brain The superior frontal sulcus is a sulcus between the superior frontal gyrus and the middle frontal gyrus. [WP,unvetted]. http://purl.obolibrary.org/obo/UBERON_0002581 postcentral gyrus http://purl.obolibrary.org/obo/UBERON_0000200 gyrus Component of the parietal lobe. The appearance and disappearance of the central sulcus were the rostral and caudal boundaries of the postcentral gyrus respectively. The medial and lateral boundaries were the lateral bank of the precentral gyrus and the lateral fissure and/or the medial bank of the superior parietal gyrus respectively (Christine Fennema-Notestine). http://purl.obolibrary.org/obo/UBERON_0002586 calcarine sulcus http://purl.obolibrary.org/obo/UBERON_0013118 sulcus of brain The calcarine fissure is an anatomical landmark located at the caudal end of the medial surface of the brain. [WP,unvetted]. http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain http://purl.obolibrary.org/obo/UBERON_0000073 regional part of nervous system Anatomical divisons of the brain according to one or more criteria, e.g. cytoarchitectural, gross anatomy. Parts may be contiguous in 3D or not, e.g., basal ganglia. http://purl.obolibrary.org/obo/UBERON_0002661 superior frontal gyrus http://purl.obolibrary.org/obo/UBERON_0015593 frontal gyrus Component of the frontal lobe, lateral aspect. The rostral boundary is the first appearance of the superior frontal sulcus whereas the caudal boundary is the midpoint of the paracentral sulcus on the "inflated" surface. The medial and lateral boundaries are the medial aspect of the frontal lobe and the superior frontal sulcus respectively (Christine Fennema-Notestine). http://purl.obolibrary.org/obo/UBERON_0002686 angular gyrus http://purl.obolibrary.org/obo/UBERON_0000200 gyrus Part of inferior parietal lobule formed by the cortex surrounding the upturned end of the superior temporal sulcus (Nolte, The Human Brain, 6th ed, 2009, pg 659) http://purl.obolibrary.org/obo/UBERON_0002688 supramarginal gyrus http://purl.obolibrary.org/obo/UBERON_0000200 gyrus Component of the parietal lobe. The first coronal slice between the superior temporal gyrus and the postcentral gyrus where the supramarginal gyrus appears was the rostral boundary whereas the slice where the supramarginal gyrus becomes continuous with the superior parietal gyrus was the caudal boundary. The medial and lateral boundaries were the lateral banks of the intraparietal sulcus and the medial banks of the lateral fissure and/or the superior temporal gyrus respectively (Christine Fennema-Notestine). http://purl.obolibrary.org/obo/UBERON_0002695 parieto-occipital sulcus http://purl.obolibrary.org/obo/UBERON_0008334 subarachnoid sulcus Only a small part of the Parietooccipital Fissure (or parieto-occipital sulcus) is seen on the lateral surface of the hemisphere, its chief part being on the medial surface. The lateral part of the parietooccipital fissure (Fig. 726) is situated about 5 cm. in front of the occipital pole of the hemisphere, and measures about 1.25 cm. in length. The medial part of the parietooccipital fissure (Fig. 727) runs downward and forward as a deep cleft on the medial surface of the hemisphere, and joins the calcarine fissure below and behind the posterior end of the corpus callosum. In most cases it contains a submerged gyrus. [WP,unvetted]. http://purl.obolibrary.org/obo/UBERON_0002702 middle frontal gyrus http://purl.obolibrary.org/obo/UBERON_0015593 frontal gyrus Component of the frontal lobe, lateral aspect (Christine Fennema-Notestine). http://purl.obolibrary.org/obo/UBERON_0002710 cingulate sulcus http://purl.obolibrary.org/obo/UBERON_0008334 subarachnoid sulcus The cingulate sulcus is a sulcus (brain fold) on the medial wall of the cerebral cortex. The frontal and parietal lobes are separated by the cingulate sulcus from the cingulate gyrus. [WP,unvetted]. http://purl.obolibrary.org/obo/UBERON_0002721 lateral sulcus http://purl.obolibrary.org/obo/UBERON_0008334 subarachnoid sulcus A sulcus that divides the frontal lobe and parietal lobe above from the temporal lobe below. It is in both hemispheres of the brain but is longer in the left hemisphere. The lateral sulcus is one of the earliest-developing sulci of the human brain. It first appears around the fourteenth gestational week[WP,modified]. http://purl.obolibrary.org/obo/UBERON_0002728 entorhinal cortex http://purl.obolibrary.org/obo/UBERON_0000064 organ part Component of the temporal lobe on the mesial surface. The rostral and caudal boundaries of the entorhinal cortex are the rostral end of the collateral sulcus and the caudal end of the amygdala respectively. The medial boundary is the medial aspect of the temporal lobe and the lateral boundary is the collateral sulcus. (DK). http://purl.obolibrary.org/obo/UBERON_0002751 inferior temporal gyrus http://purl.obolibrary.org/obo/UBERON_0000200 gyrus Component of the temporal lobe, lateral aspect. The rostral boundary is the rostral extent of the inferior temporal sulcus whereas the caudal boundary is designated as the temporo-occipital incisure on the cortical surface. The occipitotemporal sulcus is the medial boundary and the inferior temporal sulcus is the lateral boundary (Christine Fennema-Notestine). http://purl.obolibrary.org/obo/UBERON_0002769 superior temporal gyrus http://purl.obolibrary.org/obo/UBERON_0000200 gyrus Component of the temporal lobe, lateral aspect. The rostral boundary is the rostral extent of the ssuperior temporal sulcus. The caudal boundary is the cauday portion of the superior temporal gyrus (posterior to becoming continuous with the supramarginal gyrus). The medial boundary is the lateral fissure (and when present the supramarginal gyrus), and the lateral boundary is the superior temporal suclus (Christine Fennema-Notestine). http://purl.obolibrary.org/obo/UBERON_0002771 middle temporal gyrus http://purl.obolibrary.org/obo/UBERON_0000200 gyrus Component of the temporal lobe, lateral aspect. The rostral boundary is the rostral extent of the superior temporal sulcus whereas the caudal boundary is the temporo-occipital incisure on the cortical surface. The superior temporal sulcus is the medial boundary and the inferior temporal sulcus is the lateral boundary (Christine Fennema-Notestine). http://purl.obolibrary.org/obo/UBERON_0002911 parietal operculum http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain The parietal operculum, forming the superior bank of the sylvian fissure, as studied in the cat, contains the secondary somatosensory representation, 'S-II', and a second somatotopic representation (parietal ventral, or PV). Anatomically, primate S-II receives inputs from area 3 and area 1, and projects to PV and area 7. PV has projections to area 5 and premotor areas. [WP,unvetted]. http://purl.obolibrary.org/obo/UBERON_0002912 marginal sulcus http://purl.obolibrary.org/obo/UBERON_0008334 subarachnoid sulcus The marginal sulcus is the portion of the cingulate sulcus adjacent to the paracentral lobule and the precuneus. It is sometimes known as the 'marginal part of the cingulate sulcus'. [WP,unvetted]. http://purl.obolibrary.org/obo/UBERON_0002913 intraparietal sulcus http://purl.obolibrary.org/obo/UBERON_0035927 sulcus of parietal lobe The intraparietal sulcus (IPS) is located on the lateral surface of the parietal lobe, and consists of an oblique and a horizontal portion. The IPS contains a series of functionally distinct subregions that have been intensively investigated using both single cell neurophysiology in primates and human functional neuroimaging. Its principal functions are related to perceptual-motor coordination (for directing eye movements and reaching) and visual attention. The IPS is also thought to play a role in other functions, including processing symbolic numerical information, visuospatial working memory and interpreting the intent of others. [WP,unvetted]. http://purl.obolibrary.org/obo/UBERON_0002915 postcentral sulcus of parietal lobe http://purl.obolibrary.org/obo/UBERON_0035927 sulcus of parietal lobe The postcentral sulcus of the parietal lobe lies parallel to, and behind, the central sulcus in the human brain. (A sulcus is one of the prominent grooves on the surface of the brain. ) The postcentral sulcus divides the postcentral gyrus from the remainder of the parietal lobe. [WP,unvetted]. http://purl.obolibrary.org/obo/UBERON_0002947 frontal operculum http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain Portion of frontal lobe that overlaps the insular cortex (adapted from Wikipedia) http://purl.obolibrary.org/obo/UBERON_0003027 cingulate cortex http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain The cingulate cortex is a part of the brain situated in the medial aspect of the cortex. It is extended from the corpus callosum below to the cingulate sulcus above, at least anteriorly. [WP,unvetted]. http://purl.obolibrary.org/obo/UBERON_0003528 brain gray matter http://purl.obolibrary.org/obo/UBERON_0002020 gray matter A gray matter that is part of a brain [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0003876 hippocampal field http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain a part or parts of the hippocampus that have a particular function http://purl.obolibrary.org/obo/UBERON_0003947 brain ventricle/choroid plexus http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure The brain ventricles or their associated choroid plexuses http://purl.obolibrary.org/obo/UBERON_0003993 interventricular foramen of CNS http://purl.obolibrary.org/obo/UBERON_0004111 anatomical conduit The paired channels that connect the lateral and third ventricles and allows cerebrospinal fluid produced in the lateral ventricles to flow into the third ventricles http://purl.obolibrary.org/obo/UBERON_0004111 anatomical conduit http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure Any tube, opening or passage that connects two distinct anatomical spaces. http://purl.obolibrary.org/obo/UBERON_0004167 orbitofrontal cortex http://purl.obolibrary.org/obo/UBERON_0015593 frontal gyrus The region of the cerebral cortex covering the basal surface of the frontal lobes; this region normally controls emotion and decision making http://purl.obolibrary.org/obo/UBERON_0004714 septum pellucidum http://purl.obolibrary.org/obo/UBERON_0000119 cell layer A triangular double membrane, consisting of glial cells and fibers (Heimer, 1996) separating the anterior horns of the lateral ventricles of the brain. It is situated in the median plane and bounded by the corpus callosum and the body and columns of the fornix. http://purl.obolibrary.org/obo/UBERON_0004717 Brodmann (1909) area 29 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Brodmann area 29, also known as granular retrolimbic area 29 or granular retrosplenial cortex, is a cytoarchitecturally defined portion of the retrosplenial region of the cerebral cortex. In the human it is a narrow band located in the isthmus of cingulate gyrus. Cytoarchitecturally it is bounded internally by the ectosplenial area 26 and externally by the agranular retrolimbic area 30 (Brodmann-1909). http://purl.obolibrary.org/obo/UBERON_0004718 Brodmann (1909) area 26 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area . http://purl.obolibrary.org/obo/UBERON_0004923 organ component layer http://purl.obolibrary.org/obo/UBERON_0000064 organ part A part of a wall of an organ that forms a layer. http://purl.obolibrary.org/obo/UBERON_0005162 multi cell part structure http://purl.obolibrary.org/obo/UBERON_0000477 anatomical cluster A structure consisting of multiple cell components but which is not itself a cell and does not have (complete) cells as a part. http://purl.obolibrary.org/obo/UBERON_0005340 dorsal telencephalic commissure http://purl.obolibrary.org/obo/UBERON_0019294 commissure of telencephalon A fiber tracts that connect the dorsal region of the two cerebral hemispheres and span the longitudinal fissure, including the corpus callosum and hippocampal commissure[MP]. http://purl.obolibrary.org/obo/UBERON_0005358 ventricle of nervous system http://purl.obolibrary.org/obo/UBERON_0004923 organ component layer A layer in the central nervous system that lines system of communicating cavities in the brain and spinal cord. http://purl.obolibrary.org/obo/UBERON_0005401 cerebral hemisphere gray matter http://purl.obolibrary.org/obo/UBERON_0011300 gray matter of telencephalon A gray matter that is part of a cerebral hemisphere. http://purl.obolibrary.org/obo/UBERON_0005970 brain commissure http://purl.obolibrary.org/obo/UBERON_0007702 tract of brain any of the nerve fiber tracts that span the longitudinal fissure between the cerebral and/or cerebellar hemispheres of the brain http://purl.obolibrary.org/obo/UBERON_0006088 inferior parietal cortex http://purl.obolibrary.org/obo/UBERON_0000064 organ part Component of the parietal lobe. The inferior parietal cortex label includes the inferior parietal gyrus and the angular gyrus and lies inferior to the superior parietal gyrus. The rostral and caudal boundaries were the supramarginal gyrus and the parieto-occipital incisure respectively. The medial and lateral boundaries were the superior parietal gyrus and the middle temporal gyrus respectively (Christine Fennema-Notestine). http://purl.obolibrary.org/obo/UBERON_0006092 cuneus cortex http://purl.obolibrary.org/obo/UBERON_0014640 occipital gyrus Component of the occipital lobe. The rostral boundary was the first coronal slice above the calcarine sulcus where the cuneus cortex becomes visible whereas the caudal boundary was the last slice where the calcarine sulcus was visualized. The medial boundary was the most medial portion of the occipital and parietal cortices. The superio-lateral boundary was the parieto-occipital fissure whereas the inferolateral boundary was the pericalcarine cortex (Christine Fennema-Notestine). http://purl.obolibrary.org/obo/UBERON_0006093 precuneus cortex http://purl.obolibrary.org/obo/UBERON_0000200 gyrus Component of the pareital lobe. The rostral boundary was the posterior extent of the paracentral lobule whereas the caudal boundary was the lingual gyrus. The medial and lateral boundaries were the parieto-occipital fissure and the superior parietal gyrus respectively (Christine Fennema-Notestine). http://purl.obolibrary.org/obo/UBERON_0006095 anterior transverse temporal area 41 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area A subdivision of the cytoarchitecturally defined temporal region of cerebral cortex. It occupies the anterior transverse temporal gyrus (H) in the bank of the lateral sulcus on the dorsal surface of the temporal lobe. Cytoarchitecturally it is bounded medially by the parainsular area 52 (H) and laterally by the posterior transverse temporal area 42 (H) (Brodmann-1909). Adapted from Brain Info http://purl.obolibrary.org/obo/UBERON_0006096 posterior transverse temporal area 42 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area A subdivision of the cytoarchitecturally defined temporal region of cerebral cortex. It is located in the bank of the lateral sulcus on the dorsal surface of the temporal lobe. Cytoarchitecturally it is bounded medially by the anterior transverse temporal area 41(H) and laterally by the superior temporal area 22 (Brodmann-1909). Adapted from Brain Info http://purl.obolibrary.org/obo/UBERON_0006099 Brodmann (1909) area 1 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area . http://purl.obolibrary.org/obo/UBERON_0006100 Brodmann (1909) area 3 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area . http://purl.obolibrary.org/obo/UBERON_0006101 Brodmann (1909) area 24 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area . http://purl.obolibrary.org/obo/UBERON_0006102 Brodmann (1909) area 35 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Brodmann area 35, together with Brodmann area 36, is most frequently referred to as perirhinal cortex. http://purl.obolibrary.org/obo/UBERON_0006104 Brodmann (1909) area 36 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Ectorhinal area 36 is a subdivision of the cytoarchitecturally defined temporal region of cerebral cortex. With its medial boundary corresponding approximately to the rhinal sulcus it is located primarily in the fusiform gyrus. Cytoarchitecturally it is bounded laterally and caudally by the inferior temporal area 20, medially by the perirhinal area 35 and rostrally by the temporopolar area 38 (H) (Brodmann-1909). Together with Brodmann area 35, it comprises the perirhinal cortex. http://purl.obolibrary.org/obo/UBERON_0006471 Brodmann (1909) area 5 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Brodmann area 5 is one of Brodmann's cytologically defined regions of the brain. It is involved in somatosensory processing and association. http://purl.obolibrary.org/obo/UBERON_0006472 Brodmann (1909) area 6 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Brodmann area 6, or BA6, is part of the frontal cortex in the human brain. Situated just anterior to the primary motor cortex, it is composed of the premotor cortex and, medially, the supplementary motor area, or SMA. This large area of the frontal cortex is believed to play a role in the planning of complex, coordinated movements. Brodmann area 6 is also called agranular frontal area 6 in humans because it lacks an internal granular cortical layer (layer IV). It is a subdivision of the cytoarchitecturally defined precentral region of cerebral cortex. In the human brain, it is located on the portions of the precentral gyrus that are not occupied by the gigantopyramidal area 4; furthermore, BA6 extends onto the caudal portions of the superior frontal and middle frontal gyri. It extends from the cingulate sulcus on the medial aspect of the hemisphere to the lateral sulcus on the lateral aspect. It is bounded rostrally by the granular frontal region and caudally by the gigantopyramidal area 4 (Brodmann, 1909). http://purl.obolibrary.org/obo/UBERON_0006473 Brodmann (1909) area 18 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area . http://purl.obolibrary.org/obo/UBERON_0006474 Brodmann (1909) area 30 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Brodmann area 30, also known as agranular retrolimbic area 30, is a subdivision of the cytoarchitecturally defined retrosplenial region of the cerebral cortex. In the human it is located in the isthmus of cingulate gyrus. Cytoarchitecturally it is bounded internally by the granular retrolimbic area 29, dorsally by the ventral posterior cingulate area 23 and ventrolaterally by the ectorhinal area 36 (Brodmann-1909). http://purl.obolibrary.org/obo/UBERON_0006475 Brodmann (1909) area 31 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Brodmann area 31, also known as dorsal posterior cingulate area 31, is a subdivision of the cytoarchitecturally defined cingulate region of the cerebral cortex. In the human it occupies portions of the posterior cingulate gyrus and medial aspect of the parietal lobe. Approximate boundaries are the cingulate sulcus dorsally and the parieto-occipital sulcus caudally. It partially surrounds the subparietal sulcus, the ventral continuation of the cingulate sulcus in the parietal lobe. Cytoarchitecturally it is bounded rostrally by the ventral anterior cingulate area 24, ventrally by the ventral posterior cingulate area 23, dorsally by the gigantopyramidal area 4 and preparietal area 5 and caudally by the superior parietal area 7 (H) (Brodmann-1909). http://purl.obolibrary.org/obo/UBERON_0006476 Brodmann (1909) area 33 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Brodmann area 33, also known as pregenual area 33, is a subdivision of the cytoarchitecturally defined cingulate region of cerebral cortex. It is a narrow band located in the anterior cingulate gyrus adjacent to the supracallosal gyrus in the depth of the callosal sulcus, near the genu of the corpus callosum. Cytoarchitecturally it is bounded by the ventral anterior cingulate area 24 and the supracallosal gyrus (Brodmann-1909). http://purl.obolibrary.org/obo/UBERON_0006477 Brodmann (1909) area 34 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Brodmann area 34 is a part of the brain. It has been described as part of the entorhinal area. It has been described as part of the superior temporal gyrus. http://purl.obolibrary.org/obo/UBERON_0006478 Brodmann (1909) area 37 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Brodmann area 37, or BA37, is part of the temporal cortex in the human brain. This area is known as occipitotemporal area 37 (H). It is a subdivision of the cytoarchitecturally defined temporal region of cerebral cortex. It is located primarily in the caudal portions of the fusiform gyrus and inferior temporal gyrus on the mediobasal and lateral surfaces at the caudal extreme of the temporal lobe. Cytoarchitecturally it is bounded caudally by the peristriate Brodmann area 19, rostrally by the inferior temporal area 20 and middle temporal area 21 and dorsally on the lateral aspect of the hemisphere by the angular area 39 (H) (Brodmann-1909). http://purl.obolibrary.org/obo/UBERON_0006479 Brodmann (1909) area 38 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Brodmann area 38, also BA38 or temporopolar area 38 (H), is part of the temporal cortex in the human brain. BA 38 is at the anterior end of the temporal lobe, known as the temporal pole. BA38 is a subdivision of the cytoarchitecturally defined temporal region of cerebral cortex. It is located primarily in the most rostral portions of the superior temporal gyrus and the middle temporal gyrus. Cytoarchitecturally it is bounded caudally by the inferior temporal area 20, the middle temporal area 21, the superior temporal area 22 and the ectorhinal area 36 (Brodmann-1909). Cytoarchitectonic and chemoarchitectonic studies find that it contains at least seven subareas, one of which, TG, is unique to humans. 'The functional significance of this area TG is not known, but it may bind complex, highly processed perceptual inputs to visceral emotional responses.' This area is among the earliest affected by Alzheimer's disease and the earliest involved at the start of temporal lobe seizures. [ http://purl.obolibrary.org/obo/UBERON_0006480 Brodmann (1909) area 39 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area . http://purl.obolibrary.org/obo/UBERON_0006481 Brodmann (1909) area 44 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Brodmann area 44, or BA44, is part of the frontal cortex in the human brain. Situated just anterior to premotor cortex and on the lateral surface, inferior to BA9. This area is also known as pars opercularis (of the inferior frontal gyrus), and it refers to a subdivision of the cytoarchitecturally defined frontal region of cerebral cortex. In the human it corresponds approximately to the opercular part of inferior frontal gyrus (H). Thus, it is bounded caudally by the inferior precentral sulcus (H) and rostrally by the anterior ascending limb of lateral sulcus (H). It surrounds the diagonal sulcus (H). In the depth of the lateral sulcus it borders on the insula. Cytoarchitectonically it is bounded caudally and dorsally by the agranular frontal area 6, dorsally by the granular frontal area 9 and rostrally by the triangular area 45 (Brodmann-1909). http://purl.obolibrary.org/obo/UBERON_0006482 Brodmann (1909) area 45 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Part of the cytoarchitecturally defined frontal region of cerebral cortex. In the human, it occupies the triangular part of the inferior frontal gyrus (human) and, surrounding the anterior horizontal limb of the lateral sulcus (human), a portion of the orbital part of the inferior frontal gyrus (human). Bounded caudally by the anterior ascending limb of the lateral sulcus (human), it borders on the insula in the depth of the lateral sulcus. Cytoarchitectonically it is bounded caudally by the opercular area 44, rostrodorsally by the area 46 of Brodmann (human) and ventrally by the area 47 of Brodmann (human) (Brodmann-1909) (Adapted from Brain Info) http://purl.obolibrary.org/obo/UBERON_0006483 Brodmann (1909) area 46 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Brodmann area 46, or BA46, is part of the frontal cortex in the human brain. It is between BA10 and BA45. BA46 is known as middle frontal area 46. In the human it occupies approximately the middle third of the middle frontal gyrus and the most rostral portion of the inferior frontal gyrus. Brodmann area 46 roughly corresponds with the dorsolateral prefrontal cortex (DLPFC), although the borders of area 46 are based on cytoarchitecture rather than function. The DLPFC also encompasses part of granular frontal area 9, directly adjacent on the dorsal surface of the cortex. Cytoarchitecturally, BA46 is bounded dorsally by the granular frontal area 9, rostroventrally by the frontopolar area 10 and caudally by the triangular area 45 (Brodmann-1909). There is some discrepancy between the extent of BA8 (Brodmann-1905) and the same area as described by Walker (1940) http://purl.obolibrary.org/obo/UBERON_0006484 Brodmann (1909) area 47 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Brodmann area 47, or BA47, is part of the frontal cortex in the human brain. Curving from the lateral surface of the frontal lobe into the ventral (orbital) frontal cortex. It is below areas BA10 and BA45, and beside BA11. This area is also known as orbital area 47. In the human, on the orbital surface it surrounds the caudal portion of the orbital sulcus (H) from which it extends laterally into the orbital part of inferior frontal gyrus (H). Cytoarchitectonically it is bounded caudally by the triangular area 45, medially by the prefrontal area 11 of Brodmann-1909, and rostrally by the frontopolar area 10 (Brodmann-1909). It incorporates the region that Brodmann identified as 'Area 12' in the monkey, and therefore, following the suggestion of Michael Petrides, some contemporary neuroscientists refer to the region as 'BA47/12. ' BA47 has been implicated in the processing of syntax in spoken and signed languages, and more recently in musical syntax. http://purl.obolibrary.org/obo/UBERON_0007193 orbital gyrus http://purl.obolibrary.org/obo/UBERON_0000200 gyrus The inferior or orbital surface of the frontal lobe is concave, and rests on the orbital plate of the frontal bone. It is divided into four orbital gyri by a well-marked H-shaped orbital sulcus. These are named, from their position, the medial, anterior, lateral, and posterior orbital gyri. The medial orbital gyrus presents a well-marked antero-posterior sulcus, the olfactory sulcus, for the olfactory tract; the portion medial to this is named the straight gyrus, and is continuous with the superior frontal gyrus on the medial surface. http://purl.obolibrary.org/obo/UBERON_0007245 nuclear complex of neuraxis http://purl.obolibrary.org/obo/UBERON_0002020 gray matter Gray matter of the central nervous system which is a collection of clustered nuclei. http://purl.obolibrary.org/obo/UBERON_0007702 tract of brain http://purl.obolibrary.org/obo/UBERON_0001018 axon tract An axon tract that is part of a brain. http://purl.obolibrary.org/obo/UBERON_0008930 somatosensory cortex http://purl.obolibrary.org/obo/UBERON_0035014 functional part of brain Area of the parietal lobe concerned with receiving general sensations. It lies posterior to the central sulcus. http://purl.obolibrary.org/obo/UBERON_0008933 primary somatosensory cortex http://purl.obolibrary.org/obo/UBERON_0008930 somatosensory cortex (Chapin & Lin, 1984, rat): the region considered as the SI cortex is not a cytoarchitecturally homogeneous structure but consists instead of a patchwork array of areas containing dense aggregations of layer IV granule cells, surrounded by granule-cell-sparse regions. As was shown by Welker (b71,b76), and in our own mapping studies (see Fig. 3), this discontinuous pattern of granular, or koniocortical, zones contains within itself a map of the ratbs cutaneous periphery. There are clear subtypes within this cytoarchitectural subregion, notably including the bgranular aggregateb type of cytoarchitecture characteristic of the paw, limb, and mystacial vibrissae areas, and the bbarrel-fieldb type (originally described by Woolsey and Van der Loos, b70) seen in the nose and perioral regions. In the mouse, but not the rat, such barrels also cover the whole whisker representation (Welker and Woolsey, b74). http://purl.obolibrary.org/obo/UBERON_0008934 secondary somatosensory cortex http://purl.obolibrary.org/obo/UBERON_0008930 somatosensory cortex the area of the upper bank of the lateral sulcus that is involved in somatic sensation http://purl.obolibrary.org/obo/UBERON_0009834 dorsolateral prefrontal cortex http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain The dorsolateral prefrontal cortex (DL-PFC or DLPFC), according to a more restricted definition, is roughly equivalent to Brodmann areas 9 and 46.[1] According to a broader definition DL-PFC consists of the lateral portions of Brodmann areas 9 - 12, of areas 45, 46, and the superior part of area 47.[2] These regions mainly receive their blood supply from the middle cerebral artery. With respect to neurotransmitter systems, there is evidence that dopamine plays a particularly important role in DL-PFC.[2]DL-PFC is connected to the orbitofrontal cortex, and to a variety of brain areas, which include the thalamus, parts of the basal ganglia (the dorsal caudate nucleus), the hippocampus, and primary and secondary association areas of neocortex, including posterior temporal, parietal, and occipital areas http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure An anatomical structure that has more than one cell as a part. http://purl.obolibrary.org/obo/UBERON_0011215 central nervous system cell part cluster http://purl.obolibrary.org/obo/UBERON_0005162 multi cell part structure A multi cell part structure that is part of a central nervous system. http://purl.obolibrary.org/obo/UBERON_0011216 organ system subdivision http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure A subdivision of an anatomical system. http://purl.obolibrary.org/obo/UBERON_0011300 gray matter of telencephalon http://purl.obolibrary.org/obo/UBERON_0019264 gray matter of forebrain A portion of gray matter that is part of a telencephalon. http://purl.obolibrary.org/obo/UBERON_0013118 sulcus of brain http://purl.obolibrary.org/obo/UBERON_0000093 sulcus A depression or fissure in the surface of the brain. It surrounds the gyri, creating the characteristic appearance of the brain in humans and other large mammals. http://purl.obolibrary.org/obo/UBERON_0013528 Brodmann (1909) area 11 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Brodmann area 11 is one of Brodmann's cytologically defined regions of the brain. It is involved in planning, reasoning, and decision making. http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain A segmentation of the cerebral cortex on the basis of cytoarchitecture as described in Brodmann-1905, Brodmann-1909 and Brodmann-10. Maps for several species were presented. NeuroNames includes only areas in the human and in Old World monkeys. Of the latter, Brodmann studied representatives of several species including guenons (one Cercopithecus mona, one Cercocebus torquatus, and one Cercopithecus otherwise unspecified), which are all closely related African species, and one macaque (Macaca mulatta) an Asian species (Brodmann-1905). The legend to the summary map in Brodmann-1909 ascribes the areas simply to Cercopithecus. Brodmann referenced the areas by name and number. The same area number in humans and monkeys did not necessarily refer to topologically or cytoarchitecturally homologous structures. In NeuroNames the standard term for human areas consists of the English translation of Brodmann's Latin name followed by the number he assigned, e.g., agranular frontal area 6; the standard terms for monkey areas are in the format: area 6 of Brodmann-1909. He mapped a portion of areas limited to the banks of sulci, e.g., area 3 of Brodmann-1909 (Brodmann-1909) onto the adjacent, visible surface. This accounts for the fact that some areas appear larger on his surface map than on maps of other authors, e.g., area 3 of Vogts-1919. (Adapted from NeuroNames) http://purl.obolibrary.org/obo/UBERON_0013535 Brodmann (1909) area 4 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area The term area 4 of Brodmann-1909 refers to a cytoarchitecturally defined portion of the frontal lobe of the guenon. It is located predominantly in the precentral gyrus. Brodmann-1909 regarded it as topographically and cytoarchitecturally homologous to the human gigantopyramidal area 4 and noted that it occupies a much greater fraction of the frontal lobe in the monkey than in the human. Distinctive features (Brodmann-1905): the cortex is unusually thick; the layers are not distinct; the cells are relatively sparsely distributed; giant pyramidal (Betz) cells are present in the internal pyramidal layer (V); lack of an internal granular layer (IV) such that the boundary between the external pyramidal layer (III) and the internal pyramidal layer (V) is indistinct; lack of a distinct external granular layer (II); a gradual transition from the multiform layer (VI) to the subcortical white matter. http://purl.obolibrary.org/obo/UBERON_0013538 Brodmann (1909) area 7 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Brodmann area 7 is one of Brodmann's cytologically defined regions of the brain. It is involved in locating objects in space. It serves as a point of convergence between vision and proprioception to determine where objects are in relation to parts of the body. http://purl.obolibrary.org/obo/UBERON_0013539 Brodmann (1909) area 8 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Brodmann area 8 is one of Brodmann's cytologically defined regions of the brain. It is involved in planning complex movements. http://purl.obolibrary.org/obo/UBERON_0013540 Brodmann (1909) area 9 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area . http://purl.obolibrary.org/obo/UBERON_0013541 Brodmann (1909) area 10 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Brodmann area 10, or BA10, is part of the frontal cortex in the human brain. BA10 encompasses the most anterior part of the frontal cortex, known as the frontopolar region. This area is believed to play a part in strategic processes involved in memory retrieval and executive function. This area is also called frontopolar area 10, and it refers to a subdivision of the cytoarchitecturally defined frontal region of cerebral cortex. It occupies the most rostral portions of the superior frontal gyrus and the middle frontal gyrus. In humans, on the medial aspect of the hemisphere it is bounded ventrally by the superior rostral sulcus (H). It does not extend as far as the cingulate sulcus. Cytoarchitecturally it is bounded dorsally by the granular frontal area 9, caudally by the middle frontal area 46, and ventrally by the orbital area 47 and by the rostral area 12 or, in an early version of Brodmann's cortical map (Brodmann-1909), the prefrontal Brodmann area 11-1909. http://purl.obolibrary.org/obo/UBERON_0013543 Brodmann (1909) area 12 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Brodmann area 12 is a subdivision of the cerebral cortex of the guenon defined on the basis of cytoarchitecture. It occupies the most rostral portion of the frontal lobe. Brodmann-1909 did not regard it as homologous, either topographically or cytoarchitecturally, to rostral area 12 of the human. Distinctive features (Brodmann-1905): a quite distinct internal granular layer (IV) separates slender pyramidal cells of the external pyramidal layer (III) and the internal pyramidal layer (V); the multiform layer (VI) is expanded, contains widely dispersed spindle cells and merges gradually with the underlying cortical white matter; all cells, including the pyramidal cells of the external and internal pyramidal layers are inordinately small; the internal pyramidal layer (V) also contains spindle cells in groups of two to five located close to its border with the internal granular layer (IV). http://purl.obolibrary.org/obo/UBERON_0013550 Brodmann (1909) area 19 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Brodmann area 19, or BA19, is part of the occipital lobe cortex in the human brain. Along with area 18, it comprises the extrastriate (or peristriate) cortex. In normally-sighted humans, extrastriate cortex is a visual association area, with feature-extracting, shape recognition, attentional, and multimodal integrating functions. This area is also known as peristriate area 19, and it refers to a subdivision of the cytoarchitecturally defined occipital region of cerebral cortex. In the human it is located in parts of the lingual gyrus, the cuneus, the lateral occipital gyrus (H) and the superior occipital gyrus (H) of the occipital lobe where it is bounded approximately by the parieto-occipital sulcus. Cytoarchitecturally it is bounded on one side by the parastriate area 18 which it surrounds. Rostrally it is bounded by the angular area 39 (H) and the occipitotemporal area 37 (H) (Brodmann-1909). http://purl.obolibrary.org/obo/UBERON_0013552 Brodmann (1909) area 21 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Brodmann area 21, or BA21, is part of the temporal cortex in the human brain. The region encompasses most of the lateral temporal cortex, a region believed to play a part in auditory processing and language. Language function is left lateralized in most individuals. BA21 is superior to BA20 and inferior to BA40 and BA41. This area is also known as middle temporal area 21. It is a subdivision of the cytoarchitecturally defined temporal region of cerebral cortex. In the human it corresponds approximately to the middle temporal gyrus. It is bounded rostrally by the temporopolar area 38 (H), ventrally by the inferior temporal area 20, caudally by the occipitotemporal area 37 (H), and dorsally by the superior temporal area 22 (Brodmann-1909). [WP,unvetted]. http://purl.obolibrary.org/obo/UBERON_0013553 Brodmann (1909) area 22 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Brodmann area 22 is one of Brodmann's cytologically defined regions of the brain. It is involved in auditory processing. http://purl.obolibrary.org/obo/UBERON_0013554 Brodmann (1909) area 23 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area The term area 23 of Brodmann-1909 refers to a subdivision of the cerebral cortex of the guenon defined on the basis of cytoarchitecture. Brodmann regarded it as topographically and cytoarchitecturally homologous to the combined ventral posterior cingulate area 23 and dorsal posterior cingulate area 31 of the human (Brodmann-1909). Distinctive Features (Brodmann-1905): the cortex is relatively thin; smaller cells predominate; the cell density of the multiform layer (VI) is great, producing a distinct boundary with the subcortical white matter; the internal granular layer (IV) is rather well developed; the internal pyramidal layer (V) contains a dense population of round, medium-sized ganglion cells concentrated at the border with layer IV; layers V and VI are narrow with a distinct mutual boundary.nn* Definition Source NeuroNames http://purl.obolibrary.org/obo/UBERON_0013556 Brodmann (1909) area 25 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Brodmann area 25 (BA25) is an area in the cerebral cortex of the brain and delineated based on its cytoarchitectonic characteristics. It is also called the subgenual area or area subgenualis. It is the 25th 'Brodmann area' defined by Korbinian Brodmann (thus its name). BA25 is located in the cingulate region as a narrow band in the caudal portion of the subcallosal area adjacent to the paraterminal gyrus. The posterior parolfactory sulcus separates the paraterminal gyrus from BA25. Rostrally it is bound by the prefrontal area 11 of Brodmann. http://purl.obolibrary.org/obo/UBERON_0013558 Brodmann (1909) area 27 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Area 27 of Brodmann-1909 is a cytoarchitecturally defined cortical area that is a rostral part of the parahippocampal gyrus of the guenon (Brodmann-1909). It is commonly regarded as a synonym of presubiculum (Crosby-62). [WP,unvetted]. http://purl.obolibrary.org/obo/UBERON_0013559 Brodmann (1909) area 28 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area . http://purl.obolibrary.org/obo/UBERON_0013560 Brodmann (1909) area 32 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area The Brodmann area 32, also known in the human brain as the dorsal anterior cingulate area 32, refers to a subdivision of the cytoarchitecturally defined cingulate region of cerebral cortex. In the human it forms an outer arc around the anterior cingulate gyrus. The cingulate sulcus defines approximately its inner boundary and the superior rostral sulcus (H) its ventral boundary; rostrally it extends almost to the margin of the frontal lobe. Cytoarchitecturally it is bounded internally by the ventral anterior cingulate area 24, externally by medial margins of the agranular frontal area 6, intermediate frontal area 8, granular frontal area 9, frontopolar area 10, and prefrontal area 11-1909. (Brodmann19-09). Dorsal region of anterior cingulate gyrus is associated with rational thought processes, most notably active during the Stroop task. http://purl.obolibrary.org/obo/UBERON_0013573 Brodmann (1909) area 40 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area Brodmann area 40, or BA40, is part of the parietal cortex in the human brain. The inferior part of BA40 is in the area of the supramarginal gyrus, which lies at the posterior end of the lateral fissure, in the inferior lateral part of the parietal lobe. It is bounded approximately by the intraparietal sulcus, the inferior postcentral sulcus, the posterior subcentral sulcus and the lateral sulcus. Cytoarchitecturally it is bounded caudally by the angular area 39 (H), rostrally and dorsally by the caudal postcentral area 2, and ventrally by the subcentral area 43 and the superior temporal area 22 (Brodmann-1909). Cytoarchitectonically defined subregions of rostral BA40/the supramarginal gyrus are PF, PFcm, PFm, PFop, and PFt. Area PF is the homologue to macaque area PF, part of the mirror neuron system, and active in humans during imitation. The supramarginal gyrus part of Brodmann area 40 is the region in the inferior parietal lobe that is involved in reading both in regards to meaning and phonology. [WP,unvetted]. http://purl.obolibrary.org/obo/UBERON_0014640 occipital gyrus http://purl.obolibrary.org/obo/UBERON_0000200 gyrus A gyrus that is part of a occipital lobe. http://purl.obolibrary.org/obo/UBERON_0015593 frontal gyrus http://purl.obolibrary.org/obo/UBERON_0000200 gyrus A gyrus that is part of a frontal cortex. http://purl.obolibrary.org/obo/UBERON_0016526 lobe of cerebral hemisphere http://purl.obolibrary.org/obo/UBERON_0000064 organ part Subdivision of telencephalon which is one of a number of subdivisions of each hemisphere separated by both real landmarks (sulci and fissures) and arbitrary boundaries[FMA,modified]. http://purl.obolibrary.org/obo/UBERON_0016529 cortex of cerebral lobe http://purl.obolibrary.org/obo/UBERON_0005401 cerebral hemisphere gray matter Grey matter neocortex region of a lobe of the cerebral hemisphere. http://purl.obolibrary.org/obo/UBERON_0016530 parietal cortex http://purl.obolibrary.org/obo/UBERON_0016529 cortex of cerebral lobe Gray matter of the parietal region of the neocortex, located in the parietal lobe of gyrencephalic animals. It is continuous anteriorly with the frontal cortex, posteriorly with the occipital cortex and medially with the insular cortex and with the temporal cortex on the posterior/inferior border. http://purl.obolibrary.org/obo/UBERON_0016548 central nervous system gray matter layer http://purl.obolibrary.org/obo/UBERON_0022303 nervous system cell part layer A layer of of the central nervous system that is part of gray matter. http://purl.obolibrary.org/obo/UBERON_0016634 premotor cortex http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain The premotor cortex is an area of motor cortex lying within the frontal lobe of the brain. It extends 3 mm anterior to the primary motor cortex, near the Sylvian fissure, before narrowing to approximately 1 mm near the medial longitudinal fissure, which serves as the posterior border for the prefrontal cortex. The premotor cortex is largely equivalent to Brodmann area 6. Activity within this region is critical to the sensory guidance of movement and control of proximal and trunk muscles of the body. http://purl.obolibrary.org/obo/UBERON_0022303 nervous system cell part layer http://purl.obolibrary.org/obo/UBERON_0005162 multi cell part structure Single layer of a laminar structure, identified by different density, arrangement or size of cells and processes arranged in flattened layers or lamina[CUMBO]. http://purl.obolibrary.org/obo/UBERON_0024151 tegmentum http://purl.obolibrary.org/obo/UBERON_0022776 composite part spanning multiple base regional parts of brain The ventral topographic division of the midbrain; the dorsal topographic division is the tectum. Meckel (1817; see English translation, 1832, vol. 2, p. 467) apparently introduced the term and roughly its definition here for macrodissected adult humans, except he excluded the cerebral peduncle (Tarin, 1753), a white matter tract at the base of the midbrain, which is still common today but is included here. As defined here, tegmentum refers to the whole of the midbrain (Baer, 1837) excluding the tectum but including the pretectal region (Scalia, 1972); see Swanson (2000, pp. 522, 526). Usage of this term is very complex, inconsistent, and illogical; see for example Crosby et al. (1962, pp. 221, 260, 262), Carpenter (1976, p. 367 ff.). http://purl.obolibrary.org/obo/UBERON_0034751 primary auditory cortex http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain The part of the auditory cortex that is located on the superior temporal gyrus in the temporal lobe and receives point-to-point input from the ventral division of the medial geniculate complex. http://purl.obolibrary.org/obo/UBERON_0034752 secondary auditory cortex http://purl.obolibrary.org/obo/UBERON_0002616 regional part of brain The part of the auditory cortex that receive more diffuse input from the belt areas of the medial geniculate complex. http://purl.obolibrary.org/obo/UBERON_0034768 morphological feature http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure A part of an organism or organ that is continuous with its surroundings and distinguished from its surroundings based on morphology. http://purl.obolibrary.org/obo/UBERON_0034925 anatomical collection http://purl.obolibrary.org/obo/UBERON_0000465 material anatomical entity A collection of anatomical structures that are alike in terms of their morphology or developmental origin. http://purl.obolibrary.org/obo/OGMS_0000060 bodily process http://purl.obolibrary.org/obo/BFO_0000015 process A process in which at least one bodily component of an organsim participates. http://purl.obolibrary.org/obo/OGMS_0000061 pathological bodily process http://purl.obolibrary.org/obo/OGMS_0000060 bodily process A bodily process that is clinically abnormal. http://purl.obolibrary.org/obo/SYMP_0000462 symptom http://purl.obolibrary.org/obo/BFO_0000017 realizable entity A symptom is a perceived change in function, sensation, loss, disturbance or appearance reported by a patient indicative of a disease. http://purl.obolibrary.org/obo/HP_0030895 Abnormal gastrointestinal motility http://purl.obolibrary.org/obo/HP_0012719 Functional abnormality of the gastrointestinal tract An anomaly of the muscular contractions that propel food though the gastrointestinal tract. http://purl.obolibrary.org/obo/HP_0040081 Abnormal circulating creatine kinase concentration http://purl.obolibrary.org/obo/HP_0011021 Abnormality of circulating enzyme level Any deviation from the normal circulating creatine kinase concentration. http://purl.obolibrary.org/obo/NBO_0000032 paralysis http://purl.obolibrary.org/obo/NBO_0000009 locomotory behavior phenotype "Loss of power of voluntary movement in a muscle through injury or disease of its nerve supply." [JAX:] http://purl.obolibrary.org/obo/NBO_0000313 behavior process http://purl.obolibrary.org/obo/OGMS_0000060 bodily process "The action, reaction, or performance of an organism in response to external or internal stimuli." [GO:GO\:0007610] http://purl.obolibrary.org/obo/NBO_0000589 tremor http://purl.obolibrary.org/obo/NBO_0000643 involuntary movement behavior phenotype "An involuntary rhythmical, oscillatory movement of a body part." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000608 hallucination http://purl.obolibrary.org/obo/NCIT_C35470 Behavioral Disorder "Perception in the absence of a stimulus." [wikipedia:Hallucination] http://purl.obolibrary.org/obo/NBO_0000678 febrile seizure http://purl.obolibrary.org/obo/NBO_0000686 provoked seizure "A type of seizure associated with a significant rise in body temperature." [wikpedia:http\://en.wikipedia.org/wiki/Febrile_seizure] http://purl.obolibrary.org/obo/PW_0000001 pathway http://purl.obolibrary.org/obo/GO_0009987 cellular process A pathway is a set of inter-connected reactions and interactions whose delineation and scope are used as a model for exploring and studying, describing and understanding the working of and relationships between biomolecules within a context. http://purl.obolibrary.org/obo/PW_0000007 mitogen activated protein kinase signaling pathway http://purl.obolibrary.org/obo/GO_0007165 signal transduction The mitogen -activated protein kinase pathway groups several serine/threonine protein kinases mediated cascades in response to a number of extracellular stimuli. A characteristic feature of these cascades is the presence of at least three kinases in series leading to the activation of a multifunctional MAP kinase. http://purl.obolibrary.org/obo/PW_0000023 immune response pathway http://purl.obolibrary.org/obo/PW_0000001 pathway The Immune response pathways mediate the defense of host cells against infection and injury. The first line of defense is provided by the phylogenetically older innate immune response. The later, more versatile response is provided by the pathways of adaptive immunity: the B cell mediated humoral and the T cell mediated cellular or cell-mediated responses. http://purl.obolibrary.org/obo/PW_0000024 inflammatory response pathway http://purl.obolibrary.org/obo/PW_0000001 pathway Inflammation is the cellular response of the innate immune system to infection or injury. Sensing of infection by pattern recognition receptors triggers signaling cascades leading to the expression of mediator genes such as the pro-inflammatory cytokines. http://purl.obolibrary.org/obo/PW_0000060 long term potentiation http://purl.obolibrary.org/obo/PW_0000001 pathway Long-term potentiation (LTP) is a strengthening of the synapse that can last from hours to days and months. It is thought to underlie information storage and constitute the cellular basis of learning and memory. LTP engages numerous cascades of events on either side of the synapse and is accompanied by changes in gene expression. http://purl.obolibrary.org/obo/PW_0000073 lysine degradation pathway http://purl.obolibrary.org/obo/PW_0000001 pathway Those metabolic reactions involved in the degradation of lysine. In mammals, lysine is metabolized to acetyl-CoA. A derivative of lysine, allysine, is used in the production of elastin and collagen. http://purl.obolibrary.org/obo/PW_0000103 transport pathway http://purl.obolibrary.org/obo/PW_0000001 pathway A pathway that mediates or facilitates the movement of biochemical material, organic and inorganic substances and/or drugs. http://purl.obolibrary.org/obo/PW_0000138 vitamin B6 metabolic pathway http://purl.obolibrary.org/obo/PW_0000001 pathway Those metabolic reactions involving vitamin B6 - a water-soluble vitamin that exists in several forms. Vitamin B6 is required for many enzymatic reactions as the active pyridoxal 5'-phosphate (PLP) form. A number of organisms can carry out de novo synthesis of vitamin B6; humans derive it from diet. http://purl.obolibrary.org/obo/PW_0000180 mTOR signaling pathway http://purl.obolibrary.org/obo/GO_0007165 signal transduction mTOR signaling pathway regulates cellular processes such as translation, ribosome biogenesis, cell growth and autophagy and is regulated or responds to growth factors, energy metabolites and/or levels of nutrients. http://purl.obolibrary.org/obo/PW_0000204 Notch signaling pathway http://purl.obolibrary.org/obo/GO_0007165 signal transduction Notch signaling pathway regulates processes involved in early embryonic development. It plays an important role in cell fate determination. Target genes of Notch have been implicated in angiogenesis, somitogenesis, gliogenesis. Deregulation of the Notch signaling pathway underlies a broad spectrum of diseases and clinical conditions. http://purl.obolibrary.org/obo/PW_0000234 innate immune response pathway http://purl.obolibrary.org/obo/PW_0000023 immune response pathway The innate immune response - a universal and ancient form of host defense against infection - is a first line of response to various pathogens and also to damaged cells. It plays a role in stimulating adaptive immunity; molecules generated during innate responses act as second signals that can impact on both the magnitude and the nature of the adaptive response. http://purl.obolibrary.org/obo/PW_0000325 protein degradation pathway http://purl.obolibrary.org/obo/PW_0000001 pathway Those pathways involved in the degradation of proteins. http://purl.obolibrary.org/obo/PW_0000388 Reelin signaling pathway http://purl.obolibrary.org/obo/GO_0007165 signal transduction The reelin signaling pathway regulates neuronal positioning and may also play a role in synaptic plasticity. The reelin gene appears to be downregulated in schizophrenic brains but the link between the reelin pathway and the disease remains to be established. http://purl.obolibrary.org/obo/PW_0000572 brain-derived neurotrophic factor signaling pathway http://purl.obolibrary.org/obo/GO_0007165 signal transduction Brain-derived neurotrophic factor (BDNF) signaling pathway plays important roles in the growth, differentiation and survival of neurons, particularly the striatal neurons. BDNF signals via the tropomyosin-related kinase receptor type B (TrkB) to activate PKC, PI3K-AKT and MAPK/ERK intracellular pathways. Impaired BDNF signaling contributes to the pathogenesis of conditions such as Huntington Disease (HD) and psychiatric disorders. Upregulation on the other hand, is associated with several malignancies. http://purl.obolibrary.org/obo/PW_0000595 phosphatidylinositol 3-kinase signaling pathway http://purl.obolibrary.org/obo/GO_0007165 signal transduction Phosphatidylinositol kinases represent a family of lipid kinases that phosphorylate the 3' position of the inositol ring in target substrates. They are grouped into three classes: class I further subdivided into subclass A and B, class II and class III. By far the best known and characterized is class I, particularly IA that signals downstream of receptor tyrosine kinases and engages the Akt family of kinases. http://purl.obolibrary.org/obo/PW_0000754 drug pathway http://purl.obolibrary.org/obo/PW_0000001 pathway The pharmacokinetics and the pharmacodynamics pathway elicited by the administration of specific drugs. The systems involved in drug processing and responses are also those handling exogenous, xenobiotic compounds in the cellular detoxification pathway. The distinction between a random encounter with a foreign compound and the processing of a substance administered for treatment along with the importance of genetic variation for the individual responses to particular drugs warrant their separate consideration. http://purl.obolibrary.org/obo/PW_0000844 glutamate signaling pathway http://purl.obolibrary.org/obo/GO_0007165 signal transduction Glutamate signaling via the ionotropic AMPA or NMDA and several metabotropic receptors plays important roles in the modulation of synaptic plasticity, long term depression or potentiation, and in learning and memory. http://purl.obolibrary.org/obo/PW_0000848 gamma-aminobutyric acid signaling pathway http://purl.obolibrary.org/obo/GO_0007165 signal transduction Gamma-aminobutyric acid signals at inhibitory synapses via the type A receptor, which is part of a ligand-gated ion channel and the type B receptors which are metabotropic, G protein-coupled receptors. http://purl.obolibrary.org/obo/PW_0001140 calcium/calcium-mediated signaling pathway http://purl.obolibrary.org/obo/GO_0007165 signal transduction Calcium signaling impacts on a large and diverse spectrum of cellular processes such as gene expression and cell death, proliferation, muscle contraction and energy metabolism, learning, memory and synaptic plasticity. Calcium acts in signal transduction as a first as well as a second messenger. Calcium transport, which controls and maintains the calcium gradient, and calcium signaling, which the gradient promotes, are inextricably connected in the fabric of calcium homeostasis. http://purl.obolibrary.org/obo/RS_0000461 mutant strain http://purl.obolibrary.org/obo/RS_0000457 rat strain Rat strains carrying mutated alleles, spontaneously occurred, chemical-induced, genome-edited and others, are included in the mutant strain. http://purl.obolibrary.org/obo/RS_0000765 inbred strain http://purl.obolibrary.org/obo/RS_0000457 rat strain Inbred Strains are produced by brother x sister mating for 20 or more consecutive generations, and individuals of the strain can be traced to a single ancestral pair at the 20th or subsequent generation. http://purl.obolibrary.org/obo/NCIT_C103517 Epworth Sleepiness Scale Questionnaire http://purl.obolibrary.org/obo/NCIT_C91105 Clinical or Research Assessment Questionnaire A standardized rating scale used to assess an individual's general level of daytime sleepiness. http://purl.obolibrary.org/obo/NCIT_C103519 Generalized Anxiety Disorder - 7 Questionnaire http://purl.obolibrary.org/obo/NCIT_C91105 Clinical or Research Assessment Questionnaire A seven item validated, self-reported questionnaire for screening, and assessing the severity of generalized anxiety disorder in clinical practice and research settings. http://purl.obolibrary.org/obo/NCIT_C103526 Patient Health Questionnaire - 9 Item http://purl.obolibrary.org/obo/NCIT_C91105 Clinical or Research Assessment Questionnaire A 9-item scale using each of the 9 DSM-IV criteria with self-reported frequency of "0" (not at all) to "3" (nearly every day). One of the most widely used instruments to assess depression, PHQ-9 scores of 5, 10, 15, and 20 represent mild, moderate, moderately severe, and severe depression, respectively. http://purl.obolibrary.org/obo/NCIT_C107543 Treatment Satisfaction Questionnaire for Medication http://purl.obolibrary.org/obo/NCIT_C91105 Clinical or Research Assessment Questionnaire A 9 question subset of the Treatment Satisfaction Questionnaire for Medication that omits the five items of the side effects domain. http://purl.obolibrary.org/obo/NCIT_C19770 Molecular Analysis http://purl.obolibrary.org/obo/ERO_0000007 technique A laboratory procedure that involves the study of tissues, cells, and fluids using DNA/RNA analysis techniques for the identification of characteristics and abnormalities at the molecular level. http://purl.obolibrary.org/obo/NCIT_C118304 Micropsia http://purl.obolibrary.org/obo/HP_0000504 Abnormality of vision An alteration in visual perception that causes objects to appear smaller than their actual size. http://purl.obolibrary.org/obo/NCIT_C118305 Macropsia http://purl.obolibrary.org/obo/HP_0000504 Abnormality of vision An alteration in visual perception that causes objects to appear larger than their actual size. http://purl.obolibrary.org/obo/NCIT_C118507 Neonatal Seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure Abnormal hypersynchronous electrical activity in the brain of a newborn which may be associated with stereotyped movements or autonomic changes. http://purl.obolibrary.org/obo/NCIT_C118719 Monocular Diplopia http://purl.obolibrary.org/obo/HP_0000504 Abnormality of vision Perception of more than one image when viewing with one eye. http://purl.obolibrary.org/obo/NCIT_C120333 Word Pairs Delayed http://purl.obolibrary.org/obo/NCIT_C20993 Research or Clinical Assessment Tool A component of the Children's Memory Scale. A child is read a list of paired words and then asked to say the second word after being told the first. The list is presented three times in this fashion. After about 30 minutes the child is given the cued recall trial again. http://purl.obolibrary.org/obo/NCIT_C120342 Logical Memory I Subtest (WMS-IV) http://purl.obolibrary.org/obo/NCIT_C20993 Research or Clinical Assessment Tool A subtest of the Wechsler Memory Scale, 4th Edition that assesses narrative memory under a free recall condition. A short story is presented orally. Immediately after presentation of the story the subject is asked to recall the story from memory. http://purl.obolibrary.org/obo/NCIT_C121351 Occupational Therapy http://purl.obolibrary.org/obo/NCIT_C15747 Supportive Care Interventions and exercises intended to develop, recover, or maintain the ability of an individual to accomplish their activities of daily living. http://purl.obolibrary.org/obo/NCIT_C15986 Pharmacotherapy http://purl.obolibrary.org/obo/OGMS_0000112 therapeutic procedure Treatment of disease through the use of drugs. http://purl.obolibrary.org/obo/NCIT_C73501 Perinatal Brain Injury http://purl.obolibrary.org/obo/MONDO_0043510 brain injury Injury to the brain of a newborn infant occurring around the time of birth. http://purl.obolibrary.org/obo/NCIT_C86022 Comprehension http://purl.obolibrary.org/obo/MF_0000020 mental process An ability to understand the meaning or importance of something (or the knowledge acquired as a result). http://purl.obolibrary.org/obo/NCIT_C86580 Pleasure http://purl.obolibrary.org/obo/MF_0000020 mental process An emotion associated with feeling good. http://purl.obolibrary.org/obo/NCIT_C86933 Unresponsive http://purl.obolibrary.org/obo/PATO_0001995 organismal quality Failing to produce an effect from some foregoing stimulus or agent. http://purl.obolibrary.org/obo/NCIT_C87089 Irregular Respiration http://purl.obolibrary.org/obo/SYMP_0000598 respiratory abnormality A change from the normal breathing pattern in an infant, child, or adult, in terms of the amplitude and frequency of inhalations and exhalations. http://purl.obolibrary.org/obo/NCIT_C93013 3 Tesla Magnetic Resonance Imaging http://purl.obolibrary.org/obo/ERO_0001235 magnetic resonance imaging MRI that uses a magnet capable of producing a 3 telsa field strength. In theory, 3.0 T magnets have the capability to provide better image quality, with improved diagnostic performance. http://purl.obolibrary.org/obo/NCIT_C9487 Intractable Epilepsy http://purl.obolibrary.org/obo/DOID_1826 epilepsy Epilepsy that is refractory to treatment. http://purl.obolibrary.org/obo/HP_0020219 Motor seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure A motor seizure is a type of seizure that is characterized at onset by involvement of the skeletal musculature. The motor event could consist of an increase (positive) or decrease (negative) in muscle contraction to produce a movement. http://purl.obolibrary.org/obo/HP_0032663 Focal motor status epilepticus http://purl.obolibrary.org/obo/HP_0032658 Status epilepticus with prominent motor symptoms Status epilepticus with focal motor signs originating within networks limited to one hemisphere. Involves musculature in any form. The motor event could consist of an increase (positive) or decrease (negative) in muscle contraction to produce a movement. http://purl.obolibrary.org/obo/OBA_0000116 neurotransmitter levels http://purl.obolibrary.org/obo/CMO_0000000 clinical measurement The amount of a neurotransmitter. http://purl.obolibrary.org/obo/OBA_VT0005308 blood ammonia amount http://purl.obolibrary.org/obo/CMO_0000063 blood electrolyte measurement The amount of a ammonia when measured in blood. http://purl.obolibrary.org/obo/MP_0013403 abnormal circulating lactate level http://purl.obolibrary.org/obo/MP_0009642 abnormal blood homeostasis any anomaly of the amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase http://purl.obolibrary.org/obo/OGMS_0000018 laboratory finding http://purl.obolibrary.org/obo/OGMS_0000014 clinical finding A representation of a quality of a specimen that is the output of a laboratory test and that can support an inference to an assertion about some quality of the patient. http://purl.obolibrary.org/obo/OGMS_0000024 sign http://purl.obolibrary.org/obo/BFO_0000001 entity A quality of a patient, a material entity that is part of a patient, or a processual entity that a patient participates in, any one of which is observed in a physical examination and is deemed by the clinician to be of clinical significance. http://purl.obolibrary.org/obo/OGMS_0000029 vital sign http://purl.obolibrary.org/obo/OGMS_0000024 sign A physical sign in which a non-zero value is standardly considered to be an indication that the organism is alive. http://purl.obolibrary.org/obo/OGMS_0000037 abnormal homeostasis http://purl.obolibrary.org/obo/OGMS_0000032 homeostasis Homeostasis that is clinically abnormal for an organism of a given type and age in a given environment. http://purl.obolibrary.org/obo/OGMS_0000057 physical examination http://purl.obolibrary.org/obo/OGMS_0000108 health care process assay A sequence of acts of observing and measuring qualities of a patient performed by a clinician; measurements may occur with and without elicitation. http://purl.obolibrary.org/obo/OGMS_0000083 physical examination finding http://purl.obolibrary.org/obo/OGMS_0000014 clinical finding TODO: Define. http://purl.obolibrary.org/obo/OGMS_0000096 health care process http://purl.obolibrary.org/obo/OBI_0000011 planned process A planned process with the objective to improve the health status of a patient that directly involves the treatment, diagnosis, or prevention of disease or injury of a patient http://purl.obolibrary.org/obo/OGMS_0000102 injury http://purl.obolibrary.org/obo/OGMS_0000045 disorder A disorder that involves some structural damage that is immediately caused by a catastrophic external force. http://purl.obolibrary.org/obo/MONDO_0024883 metastatic neoplasm http://purl.obolibrary.org/obo/MONDO_0024882 secondary neoplasm A tumor that has spread from its original (primary) site of growth to another site, close to or distant from the primary site. Metastasis is characteristic of advanced malignancies, but in rare instances can be seen in neoplasms lacking malignant morphology. http://purl.obolibrary.org/obo/MONDO_0100030 adolescent/adult-onset epilepsy syndrome http://purl.obolibrary.org/obo/MONDO_0015650 epilepsy syndrome An epilepsy syndrome that has an onset during the adolescent or adult stage of life. http://purl.obolibrary.org/obo/HP_0020207 Reflex seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure Seizures precipitated by exogenous stimuli. http://purl.obolibrary.org/obo/HP_0020220 Focal atonic seizure http://purl.obolibrary.org/obo/HP_0011153 Focal motor seizure A focal seizure characterized at onset by sudden loss or diminution of muscle tone without apparent preceding myoclonic or tonic activity, typically lasting more than 500 ms but less than 2 seconds. It may involve the head, trunk, jaw or limb musculature. http://purl.obolibrary.org/obo/HP_0032658 Status epilepticus with prominent motor symptoms http://purl.obolibrary.org/obo/HP_0002133 Status epilepticus Status epilepticus with prominent motor signs during the prolonged seizure. http://purl.obolibrary.org/obo/HP_0032659 Non-convulsive status epilepticus with coma http://purl.obolibrary.org/obo/HP_0031475 Status epilepticus without prominent motor symptoms A type of status epilepticus without prominent motor symptoms and in the presence of coma. http://purl.obolibrary.org/obo/HP_0032660 Convulsive status epilepticus http://purl.obolibrary.org/obo/HP_0032658 Status epilepticus with prominent motor symptoms A type of status epilepticus characterized by a prolonged bilateral tonic-clonic seizure, or repeated bilateral tonic-clonic seizures without recovery between. comment: source: seeAlso: Tonic-clonic status epilepticus http://purl.obolibrary.org/obo/HP_0032661 Generalized convulsive status epilepticus http://purl.obolibrary.org/obo/HP_0032660 Convulsive status epilepticus A type of bilateral convulsive seizure of generalized onset that is sufficiently prolonged (or repeated without recovery) to reach the threshold for status epilepticus. http://purl.obolibrary.org/obo/HP_0032662 Focal-onset seizure evolving into bilateral convulsive status epilepticus http://purl.obolibrary.org/obo/HP_0032660 Convulsive status epilepticus A type of bilateral convulsive seizure of focal onset (which could be with awareness or impaired awareness, either motor or non- motor) that is sufficiently prolonged (or repeated without recovery) to reach the threshold for status epilepticus. http://purl.obolibrary.org/obo/HP_0032666 Hyperkinetic status epilepticus http://purl.obolibrary.org/obo/HP_0032658 Status epilepticus with prominent motor symptoms Status epilepticus characterized by continuous hyperkinetic proximal limb or axial muscles producing irregular sequential ballistic movements such as pedaling pelvic thrusting, thrashing, or rocking movements. http://purl.obolibrary.org/obo/HP_0032667 Myoclonic status epilepticus http://purl.obolibrary.org/obo/HP_0032658 Status epilepticus with prominent motor symptoms A type of motor status epilepticus with repeating bilateral sudden brief (less than 100 ms) involuntary single or multiple contraction of muscles or muscle groups of variable topography. http://purl.obolibrary.org/obo/HP_0032670 Tonic status epilepticus http://purl.obolibrary.org/obo/HP_0032658 Status epilepticus with prominent motor symptoms Tonic status epilepticus is a type of status epilepticus characterized by focal or bilateral limb stiffening or elevation, which may be electrographically generalized or focal. http://purl.obolibrary.org/obo/HP_0032671 Non-convulsive status epilepticus without coma http://purl.obolibrary.org/obo/HP_0031475 Status epilepticus without prominent motor symptoms A type of status epilepticus without prominent motor symptoms in the absence of coma. http://purl.obolibrary.org/obo/HP_0032673 Focal non-convulsive status epilepticus without coma https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_non_convulsive_status_epilepticus focal non convulsive status epilepticus Focal non-convulsive status epilepticus without coma is a type of status epilepticus without prominent motor signs, which is electrographically focal. It is a prolonged focal non-motor seizure. http://purl.obolibrary.org/obo/SYMP_0000424 claudication http://purl.obolibrary.org/obo/SYMP_0000099 pain A pain that is a leg pain in the calf or thigh which is caused by inadequate blood flow to the leg muscles brought on by leg exercise such as walking. http://purl.obolibrary.org/obo/SYMP_0019176 malaise http://purl.obolibrary.org/obo/SYMP_0000410 neurological and physiological symptom Malaise is a neurological and physiological symptom characterized as an indefinite feeling of debility or lack of health often indicative of or accompanying the onset of an illness. http://purl.obolibrary.org/obo/MFOMD_0000101 delusion http://purl.obolibrary.org/obo/MFOMD_0000024 pathological mental process Erroneous beliefs that usually involve a misinterpretation of perceptions or experiences. (their content may include a variety of themes (e.g., persecutory, referential, somatic, religious, or grandiose). DSM-IV-TR (american Psychiatric Association) http://purl.obolibrary.org/obo/MFOMD_0000113 flashback http://purl.obolibrary.org/obo/MFOMD_0000024 pathological mental process The recurrence of a memory, feeling, or perceptual experience from the past. DSM-IV-TR (american Psychiatric Association) http://purl.obolibrary.org/obo/MFOMD_0000119 dissociation http://purl.obolibrary.org/obo/MFOMD_0000024 pathological mental process A disruption in the usually integrated functions of consciousness, memory, identity, or perception of the environment. The disturbance may be sudden or gradual, transient or chronic. DSM-IV-TR (american Psychiatric Association) http://purl.obolibrary.org/obo/MFOMD_0000123 stupor http://purl.obolibrary.org/obo/MFOMD_0000024 pathological mental process A state of unresponsiveness with immobility and mutism. DSM-IV-TR (american Psychiatric Association) http://purl.obolibrary.org/obo/MFOMD_0000136 panic attack http://purl.obolibrary.org/obo/NCIT_C35470 Behavioral Disorder Period of intense fear or apprehension that are of sudden onset and of variable duration from minutes to hours. http://en.wikipedia.org/wiki/Panic_attack http://purl.obolibrary.org/obo/MFOMD_0000138 psychosis http://purl.obolibrary.org/obo/MFOMD_0000024 pathological mental process Symptom or feature of mental illness typically characterized by radical changes in personality, impaired functioning, and a distorted or nonexistent sense of objective reality. http://purl.obolibrary.org/obo/MFOMD_0000154 anhedonia http://purl.obolibrary.org/obo/MFOMD_0000024 pathological mental process Is defined as the inability to experience pleasure from activities usually found enjoyable, e.g. exercise, hobbies, music, sexual activities or social interactions. http://en.wikipedia.org/wiki/Anhedonia http://purl.obolibrary.org/obo/MFOMD_0000162 akinesia http://purl.obolibrary.org/obo/MFOMD_0000024 pathological mental process Absence, poverty, or loss of control of voluntary muscle movements. http://medical-dictionary.thefreedictionary.com/akinesia http://purl.obolibrary.org/obo/MFOMD_0000188 dysphoria http://purl.obolibrary.org/obo/MFOMD_0000024 pathological mental process Feeling of emotional and mental discomfort as a symptom of discontentment, restlessness, dissatisfaction, malaise, depression, anxiety or indifference. http://en.wikipedia.org/wiki/Dysphoria http://purl.obolibrary.org/obo/DOID_0111141 delayed sleep phase syndrome http://purl.obolibrary.org/obo/NBO_0000419 sleeping behavior phenotype A sleep disorder characterized by an extreme evening preference, sleep-onset insomnia, and difficulty in awakening at the desired time. http://purl.obolibrary.org/obo/DOID_0111169 subcortical band heterotopia http://purl.obolibrary.org/obo/NCIT_C84834 Malformations of Cortical Development A congenital nervous system abnormality characterized by migration of neurons to ectopic locations in the brain where the neurons form areas that appear as band-like clusters of white tissue underneath the gray tissue of the cerebral cortex. http://purl.obolibrary.org/obo/MONDO_0024361 circadian rhythm sleep disorder http://purl.obolibrary.org/obo/NBO_0000419 sleeping behavior phenotype A persistent or recurrent pattern of sleep disruption that is primarily due to an alteration of the circadian system or to a misalignment between the endogenous circadian rhythm and the sleep-wake schedule required by an individual's physical environment or social or professional schedule.(DSM IV) http://purl.obolibrary.org/obo/MONDO_0024417 perceptual disorders http://purl.obolibrary.org/obo/DOID_863 nervous system disease Cognitive disorders characterized by an impaired ability to perceive the nature of objects or concepts through use of the sense organs. These include spatial neglect syndromes, where an individual does not attend to visual, auditory, or sensory stimuli presented from one side of the body. http://purl.obolibrary.org/obo/MONDO_0024429 Alice in wonderland syndrome http://purl.obolibrary.org/obo/DOID_5614 eye disease A disorienting neuropsychological condition that affects perception. People experience size distortion such as micropsia, macropsia, pelopsia, or teleopsia. Size distortion may occur of other sensory modalities. http://purl.obolibrary.org/obo/GO_0003008 system process http://purl.obolibrary.org/obo/GO_0032501 multicellular organismal process A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective. http://purl.obolibrary.org/obo/GO_0003012 muscle system process http://purl.obolibrary.org/obo/GO_0003008 system process A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers. http://purl.obolibrary.org/obo/GO_0007165 signal transduction http://purl.obolibrary.org/obo/GO_0009987 cellular process The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. http://purl.obolibrary.org/obo/GO_0007186 G protein-coupled receptor signaling pathway http://purl.obolibrary.org/obo/GO_0007165 signal transduction A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane. http://purl.obolibrary.org/obo/GO_0007610 behavior http://purl.obolibrary.org/obo/OGMS_0000060 bodily process The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity. http://purl.obolibrary.org/obo/GO_0008150 biological_process http://purl.obolibrary.org/obo/BFO_0000015 process A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. http://purl.obolibrary.org/obo/GO_0009987 cellular process http://purl.obolibrary.org/obo/GO_0008150 biological_process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. http://purl.obolibrary.org/obo/GO_0016055 Wnt signaling pathway http://purl.obolibrary.org/obo/GO_0007165 signal transduction The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state. http://purl.obolibrary.org/obo/GO_0022414 reproductive process http://purl.obolibrary.org/obo/GO_0008150 biological_process A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. http://purl.obolibrary.org/obo/GO_0022600 digestive system process http://purl.obolibrary.org/obo/GO_0003008 system process A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism. http://purl.obolibrary.org/obo/GO_0032501 multicellular organismal process http://purl.obolibrary.org/obo/GO_0008150 biological_process Any biological process, occurring at the level of a multicellular organism, pertinent to its function. http://purl.obolibrary.org/obo/GO_0022601 menstrual cycle phase https://bio.scai.fraunhofer.de/ontology/epilepsy#trigger_factor_for_seizure trigger factor for seizure The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur. http://purl.obolibrary.org/obo/GO_0042703 menstruation http://purl.obolibrary.org/obo/GO_0022601 menstrual cycle phase The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus. http://purl.obolibrary.org/obo/GO_0043084 penile erection http://purl.obolibrary.org/obo/GO_0048609 multicellular organismal reproductive process The hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. http://purl.obolibrary.org/obo/HP_0025357 Erratic myoclonus http://purl.obolibrary.org/obo/HP_0001336 Myoclonus A type of myoclonus in which the myoclonias shift from body region to another in a random and asynchronous fashion. Erratic myoclonus can affect the face or limbs, are brief, single or repetitive, very frequent and nearly continuous. http://purl.obolibrary.org/obo/HP_0031466 Impairment in personality functioning http://purl.obolibrary.org/obo/HP_0000708 Behavioral abnormality A maladaptive personality trait characterized by moderate or greater impairment in personality (self /interpersonal) functioning. http://purl.obolibrary.org/obo/SYMP_0000898 cardiac fibrillation http://purl.obolibrary.org/obo/SYMP_0000287 arrhythmia An arrhythmia characterized by rapid, irregular, and unsynchronized contraction of muscle fibers within the heart. http://purl.obolibrary.org/obo/HP_0031815 Abnormal oral physiology http://purl.obolibrary.org/obo/HP_0000153 Abnormality of the mouth A functional anomaly of the mouth (which is also known as the oral cavity). http://purl.obolibrary.org/obo/GO_0097193 intrinsic apoptotic signaling pathway http://purl.obolibrary.org/obo/GO_0007165 signal transduction A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP). http://purl.obolibrary.org/obo/GO_0060273 crying behavior http://purl.obolibrary.org/obo/GO_0007610 behavior The behavior in which an organism sheds tears, often accompanied by non-verbal vocalizations and in response to external or internal stimuli. http://purl.obolibrary.org/obo/GO_0071626 mastication http://purl.obolibrary.org/obo/GO_0022600 digestive system process The process of biting and mashing food with the teeth prior to swallowing. http://purl.obolibrary.org/obo/MONDO_0024882 secondary neoplasm http://purl.obolibrary.org/obo/MONDO_0023370 neoplastic disease or syndrome A neoplasm that arises from a pre-existing lower grade lesion, or as a result of a primary lesion that has spread to secondary sites, or due to a complication of a cancer treatment. http://purl.obolibrary.org/obo/HP_0012847 Epilepsia partialis continua http://purl.obolibrary.org/obo/HP_0011153 Focal motor seizure Epilepsia partialis continua (also called Kojevnikov's or Kozhevnikov's epilepsia) is a type of focal motor status epilepticus characterized by repeated stereotyped simple motor manifestations such as jerks, typically of a limb or the face, recurring every few seconds or minutes for extended periods (days or years). http://purl.obolibrary.org/obo/HP_0025097 Eyelid myoclonus http://purl.obolibrary.org/obo/HP_0001336 Myoclonus Marked, involuntary jerking of the eyelids. http://purl.obolibrary.org/obo/HP_0025142 Constitutional symptom http://purl.obolibrary.org/obo/HP_0000118 Phenotypic abnormality A symptom or manifestation indicating a systemic or general effect of a disease and that may affect the general well-being or status of an individual. http://purl.obolibrary.org/obo/HP_0025144 Shivering http://purl.obolibrary.org/obo/HP_0025142 Constitutional symptom Involuntary contraction or twitching of the muscles. http://purl.obolibrary.org/obo/HP_0025236 Somnambulism http://purl.obolibrary.org/obo/NBO_0000499 NREM parasomnia Ambulation or other complex motor behaviors after getting out of bed in a sleep-like state. During sleepwalking episodes, the sonambulating individual appears confused or dazed, the eyes are usually open, and he or she might mumble or give inappropriate answers to questions, or occasionally appear agitated. http://purl.obolibrary.org/obo/HP_0025267 Snoring http://purl.obolibrary.org/obo/SYMP_0000566 sleep disturbance Deep, noisy breathing during sleep accompanied by hoarse or harsh sounds caused by the vibration of respiratory structures (especially the soft palate) resulting in sound due to obstructed air movement during breathing while sleeping. http://purl.obolibrary.org/obo/HP_0030049 Brain abscess http://purl.obolibrary.org/obo/HP_0025615 Abscess A collection of pus, immune cells, and other material in the brain. http://purl.obolibrary.org/obo/HP_0030826 Eyelid fasciculation http://purl.obolibrary.org/obo/HP_0031785 Abnormal eyelid movement Tiny, repetitive muscle contractions in the eyelids, causing the appearance of twitching. http://purl.obolibrary.org/obo/HP_0030914 Abnormal peristalsis http://purl.obolibrary.org/obo/HP_0002579 Gastrointestinal dysmotility An anomaly of the wave-like muscle contractions of the digestive tract. http://purl.obolibrary.org/obo/NBO_0000001 body part movement http://purl.obolibrary.org/obo/NBO_0000338 kinesthetic behavior A change of place or position of part of an organism that does not involve the entire organism [NBO:SMAC] http://purl.obolibrary.org/obo/NBO_0000003 emotional behavior http://purl.obolibrary.org/obo/NBO_0000313 behavior process "Behavior related to the complex psychophysiological experience of an individual's state of mind as interacting with biochemical (internal) and environmental (external) influences." [wikipedia:Emotions] http://purl.obolibrary.org/obo/NBO_0000007 mouth movement http://purl.obolibrary.org/obo/NBO_0000001 body part movement The act of moving any of the tissues and hard structures surrounding the mouth other than teeth, jaws or filter structures [NBO:AC] http://purl.obolibrary.org/obo/NBO_0000009 locomotory behavior phenotype http://purl.obolibrary.org/obo/NBO_0000644 voluntary movement behavior phenotype "Observable characteristic of behavior associated with the specific movement from place to place of an organism." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000013 locomotory behavior http://purl.obolibrary.org/obo/NBO_0000002 whole body movement Movement from place to place of an organism." [GO:0007626] http://purl.obolibrary.org/obo/NBO_0000020 head movement http://purl.obolibrary.org/obo/NBO_0000001 body part movement A change in place or position of the portion of the organism containing the brain, mouth and main sense organs [NBO:SMAC] http://purl.obolibrary.org/obo/NBO_0000027 grooming behavior http://purl.obolibrary.org/obo/NBO_0000313 behavior process The act of using body parts to pick at, rub and or remove material from exterior covering, e.g., fur, scales, feathers, skin [NBO:SMAC] http://purl.obolibrary.org/obo/NBO_0000056 walking behavior http://purl.obolibrary.org/obo/NBO_0000359 terrestrial locomotory behavior The act of locomoting on limbs with body off the ground such that at least one limb is always touching the ground [NBO:AC] http://purl.obolibrary.org/obo/NBO_0000057 scratching http://purl.obolibrary.org/obo/NBO_0000027 grooming behavior The act of dragging claws or nails over a surface [NBO:AC] http://purl.obolibrary.org/obo/NBO_0000079 feeding behavior http://purl.obolibrary.org/obo/NBO_0001845 consumption behavior The act of bringing an object or substance into the body by swallowing, surrounding or absorbing it [NBO:SMAC] http://purl.obolibrary.org/obo/NBO_0000101 retropulsion http://purl.obolibrary.org/obo/NBO_0000056 walking behavior "Moving backwards." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000119 impulsive behavior http://purl.obolibrary.org/obo/NBO_0000313 behavior process "A behavior that occur quickly without control, planning, or consideration of the consequences of that behavior." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000130 liquid consumption http://purl.obolibrary.org/obo/NBO_0000079 feeding behavior "A behavior associated with the intake of liquid." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000131 alcohol consumption http://purl.obolibrary.org/obo/NBO_0000130 liquid consumption "A drinking behavior associated with the intake of alcohol." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000243 behavioral phenotype http://purl.obolibrary.org/obo/GO_0007610 behavior "An observable characteristic of the behavior of an organism." [NBO:RH] http://purl.obolibrary.org/obo/NBO_0000308 sensation behavior http://purl.obolibrary.org/obo/NBO_0000607 cognitive behavior "Cognitive perception of a sensation by any of the five senses -- vision, touch, smell, taste, and hearing." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000338 kinesthetic behavior http://purl.obolibrary.org/obo/NBO_0000313 behavior process "Movement behavior of the body or its parts." http://purl.obolibrary.org/obo/NBO_0000359 terrestrial locomotory behavior http://purl.obolibrary.org/obo/NBO_0000013 locomotory behavior "Behavior associated with surface locomotion." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000388 involuntary movement behavior http://purl.obolibrary.org/obo/NBO_0000001 body part movement "Behavior related to movements that occur independent of planning." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000389 reflexive behavior http://purl.obolibrary.org/obo/NBO_0000388 involuntary movement behavior "Behavior related to involuntary movement in response to a stimulus." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000390 primitive reflex http://purl.obolibrary.org/obo/NBO_0000389 reflexive behavior "Reflex actions originating in the central nervous system that are exhibited by normal infants in response to particular stimuli." [wikipedia:Primitive_reflexes] http://purl.obolibrary.org/obo/NBO_0000391 startle reflex http://purl.obolibrary.org/obo/NBO_0000389 reflexive behavior "An action or movement due to the application of a sudden unexpected stimulus." [wikipedia:Startle_reflex] http://purl.obolibrary.org/obo/NBO_0000419 sleeping behavior phenotype http://purl.obolibrary.org/obo/NBO_0000473 rhythmic behavior phenotype "Observable characteristic of behavior related to the readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000493 parasomnia http://purl.obolibrary.org/obo/DOID_535 sleep disorder "A sleeping behavior phenotype that involve abnormal and unnatural movements, emotions, perceptions, and dreams that occur while falling asleep, sleeping, between sleep stages, or during arousal from sleep." [wikipedia:Parasomnia] http://purl.obolibrary.org/obo/NBO_0000499 NREM parasomnia http://purl.obolibrary.org/obo/NBO_0000419 sleeping behavior phenotype "A type of parasomnia that occurs during NREM sleep." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000545 swallowing http://purl.obolibrary.org/obo/NBO_0000079 feeding behavior The act of moving food from the mouth cavity to the esophagus through coordinated muscular movements [NBO:AC] http://purl.obolibrary.org/obo/NBO_0000568 kinesthetic behavior phenotype http://purl.obolibrary.org/obo/NBO_0000243 behavioral phenotype "Observable characteristic of behavior related to the movement of the body's muscles, tendons, and joints." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000570 head bobbing http://purl.obolibrary.org/obo/NBO_0000020 head movement Movement of the head in the vertical plane. [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000575 pilomotor reflex http://purl.obolibrary.org/obo/NBO_0000389 reflexive behavior "A reflex that elucidates goose bumps (bumps on a person's skin at the base of body hairs) which may involuntarily develop when a person is cold or experiences strong emotions such as fear, awe, admiration or sexual arousal" [wikipedia:Goose_bumps] http://purl.obolibrary.org/obo/NBO_0000607 cognitive behavior http://purl.obolibrary.org/obo/NBO_0000313 behavior process "Behaviour related to cognitive processes." [NBO:JH] http://purl.obolibrary.org/obo/NBO_0000609 visual hallucination http://purl.obolibrary.org/obo/NBO_0000308 sensation behavior "A form of hallucination that involves perceiving images without visual stimulus." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000610 auditory hallucination http://purl.obolibrary.org/obo/NBO_0000308 sensation behavior "A form of hallucination that involves perceiving sounds without auditory stimulus." [wikipedia:Auditory_hallucination] http://purl.obolibrary.org/obo/NBO_0000643 involuntary movement behavior phenotype http://purl.obolibrary.org/obo/NBO_0000568 kinesthetic behavior phenotype "Observable characteristic of behavior related to movements that occur independent of planning." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000644 voluntary movement behavior phenotype http://purl.obolibrary.org/obo/NBO_0000568 kinesthetic behavior phenotype "Observable characteristic of behavior related to movements executed with intent." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000686 provoked seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure "Paroxysmal events that mimic an epileptic seizure but do not involve abnormal, rhythmic discharges of cortical neurons." [wikipedia:http\://en.wikipedia.org/wiki/Non-epileptic_seizure] http://purl.obolibrary.org/obo/NBO_0000709 drug induced seizure http://purl.obolibrary.org/obo/NBO_0000686 provoked seizure "A type of seizure induced by the administration of a drug." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0001845 consumption behavior http://purl.obolibrary.org/obo/NBO_0000313 behavior process "Behavior related to the intake of substances." [NBOC:GVG] http://purl.obolibrary.org/obo/OGMS_0000045 disorder http://purl.obolibrary.org/obo/BFO_0000040 material entity A material entity which is clinically abnormal and part of an extended organism. Disorders are the physical basis of disease. http://purl.obolibrary.org/obo/MF_0000008 cognitive process http://purl.obolibrary.org/obo/MF_0000020 mental process A mental process that creates, modifies or has as participant some cognitive representation. http://purl.obolibrary.org/obo/MF_0000019 perception http://purl.obolibrary.org/obo/MF_0000020 mental process a mental process which is a) produced by a causal process (for example involving light rays or air vibrations) involving a part of the environment of the organism, and b) is experienced by the organism as being so caused, and c) in which the relevant part of the environment is thereby represented to the organism http://purl.obolibrary.org/obo/MF_0000020 mental process http://purl.obolibrary.org/obo/OGMS_0000060 bodily process A mental process is a bodily process that is of a type such that it can of itself be conscious. Examples include thinking, feeling pain, remembering and emotion as occurrent experiences. http://purl.obolibrary.org/obo/MF_0000033 mental disposition http://purl.obolibrary.org/obo/BFO_0000016 disposition A mental disposition is a bodily disposition that is realized in a mental process. http://purl.obolibrary.org/obo/NBO_0000017 biting http://purl.obolibrary.org/obo/NBO_0000747 jaw movement The act of seizing with teeth or jaws an object or organism so as to grip or break the surface covering [NBO:AC] http://purl.obolibrary.org/obo/NBO_0000019 licking http://purl.obolibrary.org/obo/NBO_0000748 tongue movement The act of stroking or touching with the tongue [NBO:AC] http://purl.obolibrary.org/obo/NBO_0000065 consciousness behavior http://purl.obolibrary.org/obo/NBO_0000313 behavior process "Behavior related to a variety of aspects of the relationship between the mind and the world with which it interacts." [wikipedia:Consciousness] http://purl.obolibrary.org/obo/NBO_0000432 acoustic startle reflex http://purl.obolibrary.org/obo/NBO_0000391 startle reflex "An action or movement due to the application of a sudden unexpected loud noise." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000438 snout reflex http://purl.obolibrary.org/obo/NBO_0000390 primitive reflex "A pouting or pursing of the lips that is elicited by light tapping of the closed lips near the midline." [wikipedia:Snout_reflex] http://purl.obolibrary.org/obo/NBO_0000611 olfactory hallucination http://purl.obolibrary.org/obo/NBO_0000308 sensation behavior "A form of hallucination that involves perceiving odors without odor stimulus." [NBO:GVG] http://purl.obolibrary.org/obo/NBO_0000748 tongue movement http://purl.obolibrary.org/obo/NBO_0000007 mouth movement The act of displacing part or all of the tongue from its current position [NBO:SMAC] http://purl.obolibrary.org/obo/MMO_0000024 ultrasound method http://purl.obolibrary.org/obo/ERO_0001312 imaging technique A technique which uses the visualization of deep structures of the body by recording the reflections of pulses of ultrasonic waves directed into the tissues. http://purl.obolibrary.org/obo/MMO_0000147 urine analysis http://purl.obolibrary.org/obo/CMO_0000000 clinical measurement Any method to determine the nature, properties, or composition of urine, the fluid waste product excreted by the kidneys, including measurement of the volume of urine or of the quantity or quality of component parts of urine. http://purl.obolibrary.org/obo/MMO_0000433 urine electrolyte analysis http://purl.obolibrary.org/obo/MMO_0000147 urine analysis A method which assesses the amount, proportions or properties of one or more electrolytes, any of various ions required by cells to regulate the electric charge and flow of water molecules across the cell membrane, in urine, the fluid waste product excreted by the kidneys. http://purl.obolibrary.org/obo/MMO_0000434 urine sodium analysis http://purl.obolibrary.org/obo/MMO_0000433 urine electrolyte analysis A method which assesses the amount, proportions or properties of sodium in urine, the fluid waste product excreted by the kidneys. Sodium, the chemical element with atomic number 11 that in its ionic form has lost one electron, forming a cation with a charge of +1, is the chief cation of extracellular body fluids. http://purl.obolibrary.org/obo/MMO_0000435 urine potassium analysis http://purl.obolibrary.org/obo/MMO_0000433 urine electrolyte analysis A method which assesses the amount, proportions or properties of potassium in urine, the fluid waste product excreted by the kidneys. Potassium, the chemical element with atomic number 19 that in its ionic form has lost one electron, forming a cation with a charge of +1, is the chief cation of intracellular fluid. http://purl.obolibrary.org/obo/HP_0032252 Granuloma http://purl.obolibrary.org/obo/HP_0032251 Abnormal immune system morphology A compact, organized collection of mature mononuclear phagocytes, which may be but is not necessarily accompanied by accessory features such as necrosis. http://purl.obolibrary.org/obo/NCIT_C162646 7 Tesla Magnetic Resonance Imaging http://purl.obolibrary.org/obo/ERO_0001235 magnetic resonance imaging MRI that uses a magnet capable of producing a 7 telsa field strength. This increased magnet strength is can produce images with greater signal-to-noise ratio and increased spatial resolution, or faster imaging at standard resolution. http://purl.obolibrary.org/obo/ERO_0000007 technique http://purl.obolibrary.org/obo/OBI_0000011 planned process A technique is a planned process used to accomplish a specific activity or task. http://purl.obolibrary.org/obo/ERO_0000347 intervention http://purl.obolibrary.org/obo/OBI_0000011 planned process A planned process used to influence one or more factors in a research study, and the independent variable in an interventional study wherein the influence is measured or evaluated. http://purl.obolibrary.org/obo/ERO_0000598 educational intervention http://purl.obolibrary.org/obo/ERO_0000347 intervention An intervention which involves education, training programs, and courses in various fields and disciplines, and for training groups of persons. http://purl.obolibrary.org/obo/ERO_0000606 psychological and behavioral intervention http://purl.obolibrary.org/obo/OBI_0000011 planned process Psychological or behavior intervention is a combination of program elements, strategies, or modalities designed to influence psychological or behavioral processes or outcomes. http://purl.obolibrary.org/obo/ERO_0000833 molecular assay http://purl.obolibrary.org/obo/OBI_0000070 assay An assay that generates data about the presence, abundance, structure, function, or activity of biological molecules, or a process that occurs at a molecular level of granularity. http://purl.obolibrary.org/obo/ERO_0001285 organismal assay http://purl.obolibrary.org/obo/OBI_0000070 assay An assay that generates data about the physical characteristics, physological functions, or behavior of organisms or viruses. http://purl.obolibrary.org/obo/ERO_0001286 nucleic acid assay http://purl.obolibrary.org/obo/ERO_0000833 molecular assay A molecular assay that generates data about the presence, abundance, structure, function, or activity of nucleic acids. http://purl.obolibrary.org/obo/ERO_0001292 physiological assay http://purl.obolibrary.org/obo/ERO_0001285 organismal assay An organismal assay designed to capture information pertaining to the the organic processes and phenomena of an organism or any of its parts or of a particular bodily process. http://purl.obolibrary.org/obo/ERO_0001312 imaging technique http://purl.obolibrary.org/obo/ERO_0000007 technique A technique used to create a representation or reproduction of an object's outward form; especially a visual representation (i.e., the formation of an image). http://purl.obolibrary.org/obo/ERO_0001330 neuropsychological testing http://purl.obolibrary.org/obo/ERO_0001292 physiological assay A physiological assay that utilizes systematic administration of defined procedures to measure specific psychological functions known to be linked to particular brain structures or pathways in humans. http://purl.obolibrary.org/obo/OGMS_0000073 diagnosis http://purl.obolibrary.org/obo/OGMS_0000123 clinical data item The representation of a conclusion of a diagnostic process. http://www.ebi.ac.uk/efo/EFO_0004346 neuroimaging measurement http://purl.obolibrary.org/obo/CMO_0000000 clinical measurement Non-invasive methods of visualizing and measuring the CENTRAL NERVOUS SYSTEM, especially the brain, by various imaging modalities e.g. CT scan http://www.ebi.ac.uk/efo/EFO_0005210 brain connectivity measurement http://www.ebi.ac.uk/efo/EFO_0004346 neuroimaging measurement quantification of the pattern of links between distinct units within a nervous system through neuroimaging techniques such a MRI http://purl.obolibrary.org/obo/NCIT_C19021 Rodent Model of Disease http://purl.obolibrary.org/obo/NCIT_C71164 Animal Model A rodent disease whose pathologic mechanisms are sufficiently similar to those of a human disease to serve as a model. http://purl.obolibrary.org/obo/NCIT_C19272 Transgenic Model http://purl.obolibrary.org/obo/NCIT_C71164 Animal Model A disease in a transgenic animal with pathologic mechanisms sufficiently similar to those of a human disease for the animal disease to serve as a model. http://purl.obolibrary.org/obo/NCIT_C19300 Non-Rodent Model http://purl.obolibrary.org/obo/NCIT_C71164 Animal Model Research animal models that do not include mice, rats, etc, but that might include non-human primates, cats, dogs, and others. http://purl.obolibrary.org/obo/NCIT_C21024 Deep Brain Stimulation http://purl.obolibrary.org/obo/OGMS_0000112 therapeutic procedure A highly invasive form of electroanalgesia mainly used in the management of debilitating chronic pain syndromes after all other less invasive therapeutic modalities (including SCS) have failed. (White, Li, and Chiu) http://purl.obolibrary.org/obo/NCIT_C34660 Head Injury http://purl.obolibrary.org/obo/OGMS_0000102 injury A traumatic injury to the head. http://purl.obolibrary.org/obo/NCIT_C34721 Hysteria http://purl.obolibrary.org/obo/DOID_1510 personality disorder A psychological state of emotional lability characterized by irrational behavior. This is a colloquial term that is not commonly used in clinical medicine. http://purl.obolibrary.org/obo/NCIT_C34739 Jacksonian Seizure http://purl.obolibrary.org/obo/HP_0002266 Focal clonic seizure A partial motor seizure that begins in a single area of the body and progresses to include other areas on the same side of the body. http://purl.obolibrary.org/obo/NCIT_C34865 Optical Illusion http://purl.obolibrary.org/obo/MF_0000019 perception The visual perception of an image that differs from the reality of the image. http://purl.obolibrary.org/obo/NCIT_C45234 Wound Infection http://purl.obolibrary.org/obo/IDO_0000586 infection Infection of a break in the skin or other tissue. http://purl.obolibrary.org/obo/NCIT_C50429 Missed Dose https://bio.scai.fraunhofer.de/ontology/epilepsy#trigger_factor_for_seizure trigger factor for seizure A dose of medicine that was not taken at the prescribed dosing interval. http://purl.obolibrary.org/obo/NCIT_C50465 Asphyxia http://purl.obolibrary.org/obo/OGMS_0000037 abnormal homeostasis A state of general hypoxia and hypercapnea, resulting in acidosis, which affects all tissues in the body. http://purl.obolibrary.org/obo/NCIT_C50531 Dialysis Encephalopathy http://purl.obolibrary.org/obo/NCIT_C26920 Encephalopathy A severe, often fatal encephalopathy which has been attributed to accumulation in the brain of aluminum from dialysate prepared with inadequately purified water. http://purl.obolibrary.org/obo/NCIT_C50558 Fall http://purl.obolibrary.org/obo/NCIT_C25499 Event A sudden movement downward, usually resulting in injury. http://purl.obolibrary.org/obo/NCIT_C50697 Phosphene Visualization http://purl.obolibrary.org/obo/HP_0000504 Abnormality of vision An objective visual sensation that appears with the eyes closed and in the absence of visual light. http://purl.obolibrary.org/obo/NCIT_C68680 Laser Interstitial Thermal Therapy http://purl.obolibrary.org/obo/OGMS_0000112 therapeutic procedure A thermal ablation therapy in which neoplasms are heated with prolonged and moderate temperature elevations. It results in coagulative necrosis in the heated tissue. http://purl.obolibrary.org/obo/NCIT_C69023 Miscellaneous https://bio.scai.fraunhofer.de/ontology/epilepsy#epilepsy_imitator epilepsy imitator Diverse, mixed, consisting of an assortment of different kinds. http://purl.obolibrary.org/obo/NCIT_C81292 Social History http://purl.obolibrary.org/obo/OGMS_0000015 clinical history Past events that occurred between individuals and/or their communities. http://purl.obolibrary.org/obo/HP_0031814 Palilalia http://purl.obolibrary.org/obo/HP_0002167 Neurological speech impairment Repetition of one's own words or phrases. http://purl.obolibrary.org/obo/HP_0031833 Hypometric upward saccades http://purl.obolibrary.org/obo/HP_0000571 Hypometric saccades Saccadic undershoot of upward saccadic eye movements, i.e., an upward saccadic eye movement that has less than the magnitude that would be required to gain fixation of the object. http://purl.obolibrary.org/obo/HP_0031879 Abnormal eyelid physiology http://purl.obolibrary.org/obo/HP_0032040 Abnormal ocular adnexa physiology Any functional abnormality of the eyelid. http://purl.obolibrary.org/obo/HP_0031884 Abnormal CSF glucose level http://purl.obolibrary.org/obo/HP_0025454 Abnormal CSF metabolite level A deviation from normal concentration of glucose content in the cerebrospinal fluid. http://purl.obolibrary.org/obo/HP_0031885 Hyperglycorrhachia http://purl.obolibrary.org/obo/HP_0031884 Abnormal CSF glucose level Abnormally high glucose concentration in the cerebrospinal fluid. http://purl.obolibrary.org/obo/MONDO_0042983 neurocutaneous syndrome http://purl.obolibrary.org/obo/DOID_863 nervous system disease A group of disorders characterized by ectodermal-based malformations and neoplastic growths in the skin, nervous system, and other organs. http://purl.obolibrary.org/obo/MONDO_0043264 post-traumatic epilepsy http://purl.obolibrary.org/obo/DOID_1826 epilepsy Recurrent seizures causally related to CRANIOCEREBRAL TRAUMA. Seizure onset may be immediate but is typically delayed for several days after the injury and may not occur for up to two years. The majority of seizures have a focal onset that correlates clinically with the site of brain injury. Cerebral cortex injuries caused by a penetrating foreign object (CRANIOCEREBRAL TRAUMA, PENETRATING) are more likely than closed head injuries (HEAD INJURIES, CLOSED) to be associated with epilepsy. Concussive convulsions are nonepileptic phenomena that occur immediately after head injury and are characterized by tonic and clonic movements. (From Rev Neurol 1998 Feb;26(150):256-261; Sports Med 1998 Feb;25(2):131-6) http://purl.obolibrary.org/obo/MONDO_0100025 epilepsy of infancy with migrating focal seizures http://purl.obolibrary.org/obo/MONDO_0100022 neonatal/infantile epilepsy syndrome This syndrome is characterized by onset of refractory focal seizures in the first year of life, with associated severe encephalopathy. Focal seizures arise independently in both hemispheres and can migrate from one cortical region to another randomly but consecutively in the same seizure. Seizures are often prolonged with episodes of status epilepticus. Prognosis is poor with severe neurological disability and reduced life expectancy, although a milder evolution has been reported in a few children. http://purl.obolibrary.org/obo/MONDO_0100036 variable age onset epilepsy http://purl.obolibrary.org/obo/MONDO_0015650 epilepsy syndrome An epilepsy syndrome that has an onset during variable ages and stages of life. http://purl.obolibrary.org/obo/SYMP_0000600 apnea http://purl.obolibrary.org/obo/SYMP_0000598 respiratory abnormality Apnea is a respiratory abnormality characterized by transient cessation of respiration whether normal (as in hibernating animals) or abnormal (as that caused by certain drugs). http://purl.obolibrary.org/obo/NCIT_C102117 European Quality of Life Five Dimension Five Level Scale Questionnaire http://purl.obolibrary.org/obo/NCIT_C91105 Clinical or Research Assessment Questionnaire A standardized rating scale which is used as a measure of health outcome. This instrument is a descriptive system consisting of 5 dimensions: mobility, self-care, usual activity, pain/discomfort, and anxiety/depression. Each dimension has 5 levels ranging from no problem to extreme problem or incapable, which are assessed by the patient. http://purl.obolibrary.org/obo/NCIT_C103520 Hospital Anxiety and Depression Scale Questionnaire http://purl.obolibrary.org/obo/NCIT_C91105 Clinical or Research Assessment Questionnaire A standardized survey developed and copyrighted by A. S. Zigmond and R. P. Snaith in 1983, 1992, 1994 and published in the Acta Psychiatrica Scandinavica journal (A.S. Zigmond and R.P. Snaith. The Hospital Anxiety and Depression Scale. Acta psychiart. scand. 1983, 67:361-370) which is used to detect depression and anxiety in individuals in a hospital or medical outpatient clinic. This instrument is a self-administered questionnaire consisting of 14 items that assess how the individual has felt over the past week. Each item as 4 response options that are associated with a score of 0 to 3. http://purl.obolibrary.org/obo/NCIT_C18020 Diagnostic Procedure http://purl.obolibrary.org/obo/OAE_0000002 medical intervention Any procedure or test to diagnose a disease or disorder. http://purl.obolibrary.org/obo/NCIT_C19332 Personal Attribute http://purl.obolibrary.org/obo/IAO_0000030 information content entity The distinguishing qualities or prominent aspects of an individual person. http://purl.obolibrary.org/obo/NCIT_C20993 Research or Clinical Assessment Tool http://purl.obolibrary.org/obo/NCIT_C18020 Diagnostic Procedure Any one of several evaluation/assessment tools used to ascertain a patient's condition or diagnosis. http://purl.obolibrary.org/obo/NCIT_C2959 Complication http://purl.obolibrary.org/obo/DOID_4 disease Any disease or disorder that occurs during the course of, or because of, another disease, treatment, or procedure. http://purl.obolibrary.org/obo/NCIT_C36327 Gene Abnormality https://bio.scai.fraunhofer.de/ontology/epilepsy#genetic_etiology genetic etiology A variation in or modification of the nucleic acid sequence of a gene that can alter its expression and may result in either a congenital disorder or the clinical presentation of a disease. http://purl.obolibrary.org/obo/NCIT_C41328 Electrocardiographic Finding http://purl.obolibrary.org/obo/OGMS_0000014 clinical finding Graphic representation and categorization of the electrical vectors produced by the depolarization and repolarization of myocardial tissue. http://purl.obolibrary.org/obo/NCIT_C74742 Hormone Measurement http://purl.obolibrary.org/obo/CMO_0000000 clinical measurement The determination of the amount of hormone present in a sample. http://purl.obolibrary.org/obo/NCIT_C91105 Clinical or Research Assessment Questionnaire http://purl.obolibrary.org/obo/NCIT_C20993 Research or Clinical Assessment Tool An instrument consisting of a predetermined set of questions for a clinical or research assessment. http://purl.obolibrary.org/obo/NCIT_C121459 Behavior Rating Inventory of Executive Function http://purl.obolibrary.org/obo/NCIT_C20993 Research or Clinical Assessment Tool A standardized rating scale designed to assess the executive function behaviors in the school and home environments for children and adolescents as observed by a parent or teacher. http://purl.obolibrary.org/obo/NCIT_C123667 Montreal Cognitive Assessment Functional Test http://purl.obolibrary.org/obo/NCIT_C20993 Research or Clinical Assessment Tool A standardized rating scale developed by Ziad Nasreddine in 1996 to screen for mild cognitive dysfunction and impairment. This instrument assesses the following cognitive domains: attention and concentration, executive functions, memory, language, visuoconstructional skills, conceptual thinking, calculations, and orientation. http://purl.obolibrary.org/obo/NCIT_C124040 Continuous Positive Airway Pressure http://purl.obolibrary.org/obo/OGMS_0000112 therapeutic procedure A form of non-invasive mechanical pressure support ventilation that uses a continuous positive airway pressure level to support spontaneous breathing activity. http://purl.obolibrary.org/obo/NCIT_C35470 Behavioral Disorder https://bio.scai.fraunhofer.de/ontology/epilepsy#epilepsy_imitator epilepsy imitator A specific behavioral problem that occurs in persistent patterns and characteristic clusters and that causes clinically significant impairment. http://purl.obolibrary.org/obo/NCIT_C71164 Animal Model http://purl.obolibrary.org/obo/NCIT_C19148 In Vivo Model An animal that is amenable to experimentation and whose physiological or pathologic mechanisms are sufficiently similar to those of a human for the animal to serve as a model. http://purl.obolibrary.org/obo/NCIT_C15186 Biofeedback http://purl.obolibrary.org/obo/NCIT_C15308 Psychotherapy A training technique in which various bodily functions, such as heart rate, skin temperature, muscle tension, and brain activity are monitored so that people can learn to control them voluntarily so as to improve their health and physical performance. http://purl.obolibrary.org/obo/NCIT_C15272 Lobectomy http://purl.obolibrary.org/obo/OMIABIS_0001041 surgical procedure Surgical removal of a lobe of an organ. http://purl.obolibrary.org/obo/NCIT_C15308 Psychotherapy http://purl.obolibrary.org/obo/OGMS_0000112 therapeutic procedure A method of treating disease, esp. psychic disorders, by mental rather than pharmacological means (e.g., suggestion, re-education, hypnotism, and psychoanalysis). (Taber's) http://purl.obolibrary.org/obo/NCIT_C15359 Salvage Therapy http://purl.obolibrary.org/obo/OGMS_0000112 therapeutic procedure Performing a salvage procedure is the last resort. The clinical situation involves either ongoing life support measures, life support measures for more than 60 seconds during the prior 10 minutes, or unanticipated institution of extracorporeal circulatory support. (ACC) http://purl.obolibrary.org/obo/NCIT_C15420 Hypnotherapy http://purl.obolibrary.org/obo/NCIT_C15308 Psychotherapy Therapeutic use of hypnotism by a clinical professional. http://purl.obolibrary.org/obo/NCIT_C64345 Cognitive Behavior Therapy http://purl.obolibrary.org/obo/NCIT_C15308 Psychotherapy A type of psychotherapy utilized to treat different forms of mental disorders.The treatment involves the identification of unhelpful or destructive patterns of thinking and behaviors and the subsequent replacement with behaviors that are beneficial and constructive. http://purl.obolibrary.org/obo/NCIT_C84834 Malformations of Cortical Development https://bio.scai.fraunhofer.de/ontology/epilepsy#structural_etiology structural etiology A group of neural cortical developmental malformations of diverse genetic causes. Clinical manifestations include epilepsy and developmental delays. http://purl.obolibrary.org/obo/NCIT_C84932 Neurocysticercosis https://bio.scai.fraunhofer.de/ontology/epilepsy#infectious_etiology infectious etiology A parasitic infection with tapeworms of the genus Taenia affecting the brain. It is manifested with seizures and headaches. http://purl.obolibrary.org/obo/NCIT_C84973 Orthostatic Intolerance http://purl.obolibrary.org/obo/HP_0001279 Syncope A condition characterized by development of symptoms while standing. It is an autonomic nervous system disorder and the symptoms are relieved once the person sits back down. Symptoms include heart palpitations, sweating, anxiety, lightheadedness, hyperpnea, anxiety, and blurred vision. http://purl.obolibrary.org/obo/NCIT_C99020 Porencephalic Cyst https://bio.scai.fraunhofer.de/ontology/epilepsy#structural_etiology structural etiology A congenital or acquired cystic cavity within the cerebral hemisphere. http://purl.obolibrary.org/obo/MONDO_0021081 anti-NMDA receptor encephalitis http://purl.obolibrary.org/obo/MONDO_0100029 antibody mediated epilepsy An autoimmune acute encephalitis caused by antibodies against the glutamate NMDA receptor. It usually affects females and in the majority of cases it is associated with the presence of a tumor, most commonly an ovarian teratoma. The presence of a tumor in patients with this form of encephalitis implies that the latter is a paraneoplastic syndrome. It is manifested with psychiatric symptoms and epileptic seizures. It is a potentially lethal disorder; however, it is usually reversible with the prompt removal of the tumor. http://purl.obolibrary.org/obo/MONDO_0024291 vascular malformation https://bio.scai.fraunhofer.de/ontology/epilepsy#structural_etiology structural etiology A non-neoplastic disorder that is the result of defects of vascular morphogenesis. http://purl.obolibrary.org/obo/HP_0025373 Interictal EEG abnormality http://purl.obolibrary.org/obo/HP_0002353 EEG abnormality Interictal refers to a period of time between epileptic seizures. Electroencephalographic (EEG) patterns are important in the differential diagnosis of epilepsy, and the EEG is almost always abnormal during a seizure. Some persons with seizures may show EEG abnormalities between seizures, while others do not. In some cases, multiple interictal EEGs must be recorded before an abnormality is observed. In most cases the electrographic pattern of seizure onset is completely different from the activity recorded during interictal discharge. http://purl.obolibrary.org/obo/NCIT_C103849 Pittsburgh Sleep Quality Index http://purl.obolibrary.org/obo/NCIT_C20993 Research or Clinical Assessment Tool A self-rated questionnaire which assesses sleep quality and disturbances over a one month time interval. http://purl.obolibrary.org/obo/NCIT_C17204 Computed Tomography http://purl.obolibrary.org/obo/ERO_0001312 imaging technique A method of examining structures within the body by scanning them with X rays and using a computer to construct a series of cross-sectional scans along a single axis. http://purl.obolibrary.org/obo/NCIT_C25499 Event http://purl.obolibrary.org/obo/BFO_0000015 process Something that happens at a given place and time. http://purl.obolibrary.org/obo/NCIT_C98909 Cyanotic Attacks in Children http://purl.obolibrary.org/obo/HP_0001279 Syncope Episodes of cyanosis that result from breath holding spells in response to anger or frustration, during childhood. These episodes usually resolve in a few seconds. http://purl.obolibrary.org/obo/NCIT_C112286 Ghrelin Measurement http://purl.obolibrary.org/obo/NCIT_C74742 Hormone Measurement The determination of the amount of ghrelin present in a sample. http://purl.obolibrary.org/obo/NCIT_C113191 Have Feeling of Fullness or Heaviness in Stomach Area http://purl.obolibrary.org/obo/SYMP_0000459 digestive system symptom A question about whether an individual has or had a feeling of fullness or heaviness in the area of the stomach. http://purl.obolibrary.org/obo/NCIT_C114781 Dialysis Disequilibrium Syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome A complication occurring during hemodialysis that is thought to be due to a rapid decrease in blood urea nitrogen, and is characterized by an increase in intracranial pressure resulting in nausea, headache, vomiting, restlessness, and/or a decreased level of consciousness. http://purl.obolibrary.org/obo/NCIT_C16866 Model http://purl.obolibrary.org/obo/IAO_0000030 information content entity A representation of something, often idealized or modified to make it conceptually easier to understand. http://purl.obolibrary.org/obo/NCIT_C49936 Electrode Device http://purl.obolibrary.org/obo/OBI_0000968 device A conductor that is designed to make contact with part of a circuit or system. http://purl.obolibrary.org/obo/NCIT_C127816 WHO Grade III Glioma http://purl.obolibrary.org/obo/MONDO_0015917 malignant glioma A group of malignant gliomas that includes anaplastic astrocytoma, anaplastic oligodendroglioma, anaplastic oligoastrocytoma, and anaplastic ependymoma. http://purl.obolibrary.org/obo/NCIT_C86974 Wechsler Preschool and Primary Scale of Intelligence http://purl.obolibrary.org/obo/NCIT_C20993 Research or Clinical Assessment Tool An intelligence test published by Harcourt Assessment and designed for children ages 2 years 6 months to 7 years 3 months. It provides subtest and composite scores that represent intellectual functioning in verbal and performance cognitive domains, and provides a composite score that represents a child's general intellectual ability. http://purl.obolibrary.org/obo/NCIT_C16358 Body Mass Index http://purl.obolibrary.org/obo/NCIT_C19332 Personal Attribute An individual's weight in kilograms divided by the square of the height in meters. http://purl.obolibrary.org/obo/NCIT_C16390 Etiology https://bio.scai.fraunhofer.de/ontology/epilepsy#International_League_Against_Epilepsy_classification International League Against Epilepsy classification The cause of a disease or abnormal condition. http://purl.obolibrary.org/obo/NCIT_C16811 Magnetoencephalography http://purl.obolibrary.org/obo/ERO_0001312 imaging technique The measurement of the magnetic fields produced by electrical activity in the brain, usually conducted externally, using extremely sensitive devices. The measurement of electric fields in the brain provides information about the localization of brain activity which is complementary to that provided by electroencephalography. http://purl.obolibrary.org/obo/NCIT_C17429 Neural Network http://purl.obolibrary.org/obo/NCIT_C61377 Network A computer algorithm to solve non-linear optimization problems. The algorithm was derived in analogy to the way the densely interconnected, parallel structure of the brain processes information. http://purl.obolibrary.org/obo/NCIT_C17883 Palliative Surgery http://purl.obolibrary.org/obo/NCIT_C161601 Surgical Procedure by Type Surgery that does not alter the course of a disease, but improves the quality of life. http://purl.obolibrary.org/obo/NCIT_C18280 Cytogenetic Analysis http://purl.obolibrary.org/obo/NCIT_C19770 Molecular Analysis Techniques for analysis of chromosomal and subchromosomal properties and structures, such as those to diagnose, classify, screen for, or manage genetic diseases and abnormalities. http://purl.obolibrary.org/obo/NCIT_C18772 Personal Medical History http://purl.obolibrary.org/obo/NCIT_C19332 Personal Attribute A record of a patient's background regarding health and the occurrence of disease events of the individual. In addition, personal medical history may be a variable in epidemiologic studies. http://purl.obolibrary.org/obo/NCIT_C80519 Biological Model http://purl.obolibrary.org/obo/NCIT_C16866 Model Systems designed to elucidate facts about complex biological phenomena, usually in a less complex or theoretical test environment. http://purl.obolibrary.org/obo/NCIT_C139982 Pre-operative Evaluation http://purl.obolibrary.org/obo/OBI_0000011 planned process An examination of an individual to determine their health status prior to a surgical procedure and their suitability for the procedure. http://purl.obolibrary.org/obo/SYMP_0000005 ataxia http://purl.obolibrary.org/obo/SYMP_0000410 neurological and physiological symptom Ataxia is a neurological and physiological symptom characterized by an inability to coordinate voluntary muscular movements that is symptomatic of some nervous disorders. http://purl.obolibrary.org/obo/NCIT_C9505 Dysembryoplastic Neuroepithelial Tumor http://purl.obolibrary.org/obo/HP_0002664 Neoplasm A benign glial-neuronal neoplasm. It is usually supratentorial, located, generally, in the cortex and occurs in children and young adults with a long-standing history of partial seizures. A histologic hallmark of this tumor is the 'specific glioneuronal element', characterized by columns, made up of bundles of axons, oriented perpendicularly to the cortical surface. (Adapted from WHO) http://purl.obolibrary.org/obo/MONDO_0021637 low grade glioma http://purl.obolibrary.org/obo/MONDO_0021042 glioma A grade I or grade II glioma arising from the central nervous system. This category includes pilocytic astrocytoma, diffuse astrocytoma, subependymal giant cell astrocytoma, ependymoma, oligodendroglioma, oligoastrocytoma, and angiocentric glioma. http://purl.obolibrary.org/obo/MONDO_0021638 low grade astrocytic tumor http://purl.obolibrary.org/obo/MONDO_0021637 low grade glioma A grade I or grade II astrocytic tumor. This category includes pilocytic astrocytoma (grade I), subependymal giant cell astrocytoma (grade I), and diffuse astrocytoma (grade II). http://purl.obolibrary.org/obo/MONDO_0021639 grade II glioma http://purl.obolibrary.org/obo/MONDO_0021637 low grade glioma A glioma arising from the central nervous system. This category includes diffuse astrocytoma, ependymoma, oligodendroglioma, and oligoastrocytoma. http://purl.obolibrary.org/obo/HP_0031785 Abnormal eyelid movement http://purl.obolibrary.org/obo/HP_0031879 Abnormal eyelid physiology An abnormality in voluntary or involuntary eyelid movements or their control. http://purl.obolibrary.org/obo/HP_0025613 Focal emotional seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_non-motor_onset_seizure focal non-motor onset seizure A type of focal-onset seizure characterized by alterations in mood or emotion, or the appearance of altered emotion without the subjective emotion, at seizure onset. These emotional seizures may occur with or without objective clinical signs of a seizure evident to the observer. http://purl.obolibrary.org/obo/HP_0500165 Abnormal blood oxygen level http://purl.obolibrary.org/obo/HP_0012415 Abnormal blood gas level An abnormality of the partial pressure of oxygen in the arterial blood. http://purl.obolibrary.org/obo/HP_0032180 Abnormal circulating metabolite concentration http://purl.obolibrary.org/obo/HP_0001939 Abnormality of metabolism/homeostasis An abnormal level of an analyte measured in the blood. http://purl.obolibrary.org/obo/SYMP_0000537 cyanosis http://purl.obolibrary.org/obo/SYMP_0000488 skin and integumentary tissue symptom Cyanosis is a skin and integumentary tissue symptom characterized as a bluish or purplish discoloration (as of skin) due to deficient oxygenation of the blood. http://purl.obolibrary.org/obo/HP_0030972 Abnormal systemic blood pressure http://purl.obolibrary.org/obo/HP_0011025 Abnormal cardiovascular system physiology A chronic deviation from normal pressure in the systemic arterial system. http://purl.obolibrary.org/obo/MONDO_0007295 rolandic epilepsy http://purl.obolibrary.org/obo/DOID_1826 epilepsy Rolandic epilepsy (RE) is a focal childhood epilepsy characterized by seizures consisting of unilateral facial sensory-motor symptoms, with electroencephalogram (EEG) showing sharp biphasic waves over the rolandic region. It is an age-related epilepsy, with excellent outcome. http://purl.obolibrary.org/obo/MONDO_0015346 Jeavons syndrome http://purl.obolibrary.org/obo/MONDO_0020072 childhood-onset epilepsy syndrome Jeavons syndrome is an idiopathic generalized form of reflex epilepsy characterized by childhood onset, unique seizure manifestations, striking light sensitivity, and possible occurrence of generalized tonic-clonic seizures. http://purl.obolibrary.org/obo/MONDO_0015648 startle epilepsy http://purl.obolibrary.org/obo/DOID_2548 reflex epilepsy Startle epilepsy is a rare neurologic disease characterized by frequent and spontaneous epileptic seizures (frequently with symmetrical or asymmetrical tonic features) triggered by a normal startle in response to a sudden and unexpected somatosensory (most frequently auditory) stimulus. Falls are common and can be traumatic. In most cases, the disease is associated with spastic hemi-, di-, or tetraplegia and intellectual disability. http://purl.obolibrary.org/obo/MONDO_0016019 Rasmussen subacute encephalitis https://bio.scai.fraunhofer.de/ontology/epilepsy#immune_etiology immune etiology A rare, progressive chronic inflammation of a single cerebral hemisphere that usually affects children. It is characterized by severe seizures, loss of motor skills and speech, hemiparesis, and dementia. http://purl.obolibrary.org/obo/MONDO_0018215 paraneoplastic neurologic syndrome http://purl.obolibrary.org/obo/DOID_936 brain disease A paraneoplastic syndrome that involves the nervous system. http://purl.obolibrary.org/obo/MONDO_0021248 nervous system neoplasm http://purl.obolibrary.org/obo/MONDO_0005070 neoplasm (disease) A neoplasm (disease) that involves the nervous system. http://purl.obolibrary.org/obo/HP_0032039 Abnormality of the ocular adnexa http://purl.obolibrary.org/obo/HP_0000315 Abnormality of the orbital region An anomaly of the adjacent structures (i.e., adnexa) of the eye, defined as the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva. http://purl.obolibrary.org/obo/HP_0032040 Abnormal ocular adnexa physiology http://purl.obolibrary.org/obo/HP_0032039 Abnormality of the ocular adnexa A functional anomaly of the adjacent structures (i.e., adnexa) of the eye, defined as the lacrimal apparatus, the extraocular muscles and the eyelids, eyelashes, eyebrows and the conjunctiva. http://purl.obolibrary.org/obo/HP_0032046 Focal cortical dysplasia http://purl.obolibrary.org/obo/NCIT_C84834 Malformations of Cortical Development A type of malformation of cortical development that primarily affects areas of neocortex. It can be identified on conventional magnetic resonance imaging as focal cortical thickening, abnormal gyration, and blurring between gray and white matter, often associated with clusters of heterotopic neurons. http://purl.obolibrary.org/obo/HP_0032047 Focal cortical dysplasia type I http://purl.obolibrary.org/obo/HP_0032046 Focal cortical dysplasia A type of focal cortical dysplasia that is characterized by abnormal cortical layering. http://purl.obolibrary.org/obo/HP_0032048 Focal cortical dysplasia type Ia http://purl.obolibrary.org/obo/HP_0032047 Focal cortical dysplasia type I A subtype of focal cortical dysplasia type I that is characterized by abnormal radial cortical lamination. http://purl.obolibrary.org/obo/HP_0032049 Focal cortical dysplasia type Ib http://purl.obolibrary.org/obo/HP_0032047 Focal cortical dysplasia type I A subtype of focal cortical dysplasia type I that is characterized by abnormal tangential cortical lamination. http://purl.obolibrary.org/obo/HP_0032050 Focal cortical dysplasia type Ic http://purl.obolibrary.org/obo/HP_0032047 Focal cortical dysplasia type I A subtype of focal cortical dysplasia type I that is characterized by abnormal radial and tangential cortical lamination. http://purl.obolibrary.org/obo/HP_0032051 Focal cortical dysplasia type II http://purl.obolibrary.org/obo/HP_0032046 Focal cortical dysplasia A type of focal cortical dysplasia that is characterized by disrupted cortical lamination and specific cytological abnormalities. http://purl.obolibrary.org/obo/HP_0032052 Focal cortical dysplasia type IIa http://purl.obolibrary.org/obo/HP_0032051 Focal cortical dysplasia type II A subtype of focal cortical dysplasia type II that is characterized by dysmorphic neurons, which present with a significantly enlarged cell body and nucleus, malorientation, abnormally distributed intracellular Nissl substance and cytoplasmic accumulation of neurofilament proteins. http://purl.obolibrary.org/obo/HP_0032053 Focal cortical dysplasia type IIb http://purl.obolibrary.org/obo/HP_0032051 Focal cortical dysplasia type II A subtype of focal cortical dysplasia type II that is characterized by dysmorphic neurons (significantly enlarged with accumulation of neurofilament proteins) and balloon cells. http://purl.obolibrary.org/obo/HP_0032054 Focal cortical dysplasia type III http://purl.obolibrary.org/obo/HP_0032046 Focal cortical dysplasia A type of focal cortical dysplasia that is characterized by cortical lamination abnormalities associated with a principal lesion, usually adjacent to or affecting the same cortical area/lobe. http://purl.obolibrary.org/obo/HP_0032055 Focal cortical dysplasia type IIIa http://purl.obolibrary.org/obo/HP_0032054 Focal cortical dysplasia type III A subtype of focal cortical dysplasia type III that is characterized by alterations in architectural organisation (cortical dyslamination) or cytoarchitectural composition (hypertrophic neurons outside Layer 5) in patients with hippocampal sclerosis (HS, syn. Ammon's horn sclerosis). http://purl.obolibrary.org/obo/HP_0032056 Focal cortical dysplasia type IIIb http://purl.obolibrary.org/obo/HP_0032054 Focal cortical dysplasia type III A subtype of focal cortical dysplasia type III that is characterized by altered architectural (cortical dyslamination, hypoplasia without six-layered structure) and/or cytoarchitectural composition (hypertrophic neurons) of the neocortex, which occur adjacent to glial or glioneuronal tumor. http://purl.obolibrary.org/obo/HP_0032057 Focal cortical dysplasia type IIIc http://purl.obolibrary.org/obo/HP_0032054 Focal cortical dysplasia type III A subtype of focal cortical dysplasia type III that is characterized by alterations in architectural (cortical dyslamination, hypoplasia) or cytoarchitectural composition of the neocortex (hypertrophic neurons), which occur adjacent to vascular malformations (cavernomas, arteriovenous malformations, leptomeningeal vascular malformations, telangiectasias, meningioangiomatosis). http://purl.obolibrary.org/obo/HP_0032058 Focal cortical dysplasia type IIId http://purl.obolibrary.org/obo/HP_0032054 Focal cortical dysplasia type III A subtype of focal cortical dysplasia type III that is characterized by altered architectural (cortical dyslamination, hypoplasia without six-layered structure) or cytoarchitectural composition (hypertrophic neurons) of the neocortex, which occur adjacent to other lesions acquired during early life (not included into FCD Type IIIa-c). These lesions comprise a large spectrum including traumatic brain injury, glial scarring after prenatal or perinatal ischemic injury or bleeding, and inflammatory or infectious diseases, i.e. Rasmussen encephalitis, limbic encephalitis, bacterial or viral infections. http://purl.obolibrary.org/obo/HP_0500173 Reflex asystolic syncope http://purl.obolibrary.org/obo/HP_0001279 Syncope A loss of consciousness followed by stiffening and brief clonic movements affecting some or all limbs, often misinterpreted as an epileptic seizure. http://purl.obolibrary.org/obo/HP_0032316 Family history http://purl.obolibrary.org/obo/OGMS_0000015 clinical history Information about close relatives of an individual who is the proband of a study or who is being investigated with the goal of identifying a medical diagnosis. Usually, the family history includes information from three generations of relatives, including children, brothers and sisters, parents, aunts and uncles, nieces and nephews, grandparents, and cousins. http://purl.obolibrary.org/obo/SYMP_0000508 aphasia http://purl.obolibrary.org/obo/SYMP_0000480 nervous system symptom Aphasia is a nervous system symptom characterized by a loss or impairment of the power to use or comprehend words usually resulting from brain damage. http://purl.obolibrary.org/obo/NCIT_C38047 Curative Surgery http://purl.obolibrary.org/obo/NCIT_C161601 Surgical Procedure by Type Surgery which cures disease. http://purl.obolibrary.org/obo/NCIT_C40438 Beck Depression Inventory http://purl.obolibrary.org/obo/NCIT_C20993 Research or Clinical Assessment Tool A twenty-one question survey completed by a patient, with each answer scored on a scale of 0 to 3, designed to measure presence of depression. http://purl.obolibrary.org/obo/SYMP_0000061 inflammation http://purl.obolibrary.org/obo/SYMP_0000567 general symptom Inflammation is a general symptom where there is a local response to cellular injury that is marked by capillary dilatation, leukocytic infiltration, redness, heat, pain, swelling, and often loss of function and that serves as a mechanism initiating the elimination of noxious agents and of damaged tissue. http://purl.obolibrary.org/obo/SYMP_0000075 lethargy http://purl.obolibrary.org/obo/SYMP_0019177 fatigue Lethargy is a fatigue characterized as abnormal drowsiness. http://purl.obolibrary.org/obo/SYMP_0000099 pain http://purl.obolibrary.org/obo/SYMP_0000892 sensation perception A sensation perception where there is an unpleasant sensation that usually indicates the body is threatened or damaged. The sensation may be sharp or dull, short-lived or chronic, intermittent or continual, confined to one area or spread over the entire body. http://purl.obolibrary.org/obo/SYMP_0000406 bruise http://purl.obolibrary.org/obo/SYMP_0000488 skin and integumentary tissue symptom Bruise is a skin and integumentary tissue symptom characterized as an injury transmitted through unbroken skin to underlying tissue causing rupture of small blood vessels and escape of blood into the tissue with resulting discoloration. http://purl.obolibrary.org/obo/SYMP_0000412 anxiety http://purl.obolibrary.org/obo/SYMP_0000410 neurological and physiological symptom Anxiety is a neurological and physiological symptom characterized by a painful or apprehensive uneasiness of mind usually over an impending or anticipated ill. http://purl.obolibrary.org/obo/SYMP_0000458 nausea http://purl.obolibrary.org/obo/SYMP_0000459 digestive system symptom Nausea is a digestive system symptom characterized by an uneasy or unsettled feeling in the stomach together with an urge to vomit. http://purl.obolibrary.org/obo/SYMP_0000492 urinary incontinence http://purl.obolibrary.org/obo/SYMP_0000486 urinary system symptom Urinary incontinence is a urinary system symptom characterized by the an inability of the body to control the evacuative functions. http://purl.obolibrary.org/obo/SYMP_0000530 palpitation http://purl.obolibrary.org/obo/SYMP_0000528 cardiovascular system symptom Palpitation is a cardiovascykar system symptom characterized by an abnormal awareness of the beating of the heart,whether it is too slow, too fast, irregular, or at its normal frequency when excited by violent exertion, strong emotion, or disease. http://purl.obolibrary.org/obo/SYMP_0000892 sensation perception http://purl.obolibrary.org/obo/SYMP_0000480 nervous system symptom Sensation perception is a nervous system symptom where the information perceived by sensory receptors are interpreted. http://purl.obolibrary.org/obo/SYMP_0019177 fatigue http://purl.obolibrary.org/obo/SYMP_0000410 neurological and physiological symptom Fatigue is a neurological and physiological symptom characterized by a weariness or exhaustion from labor, exertion, or stress. http://purl.obolibrary.org/obo/NCIT_C154766 Gamma-Aminobutyric Acid Measurement http://purl.obolibrary.org/obo/OBA_0000116 neurotransmitter levels The determination of the amount of gamma-aminobutyric acid present in a sample. http://purl.obolibrary.org/obo/OGMS_0000112 therapeutic procedure http://purl.obolibrary.org/obo/OGMS_0000090 treatment A treatment whose completion is hypothesized by a health care provider to eliminate a disorder or to alleviate the signs and symptoms of a disorder or pathological process. http://purl.obolibrary.org/obo/OGMS_0000114 immunotherapy procedure http://purl.obolibrary.org/obo/OGMS_0000112 therapeutic procedure A therapeutic procedure that uses immune system derived entities. http://purl.obolibrary.org/obo/OGMS_0000115 physical therapy procedure http://purl.obolibrary.org/obo/OGMS_0000112 therapeutic procedure a therapeutic procedure that uses physical conditioning http://purl.obolibrary.org/obo/OGMS_0000123 clinical data item http://purl.obolibrary.org/obo/IAO_0000027 data item a data item that is about a patient and is the specified output of a health care process assay or diagnostic process http://purl.obolibrary.org/obo/BFO_0000148 zero-dimensional temporal region http://purl.obolibrary.org/obo/BFO_0000008 temporal region temporal instant. http://purl.obolibrary.org/obo/HP_0011458 Abdominal symptom http://purl.obolibrary.org/obo/HP_0025032 Abnormality of digestive system physiology https://bio.scai.fraunhofer.de/ontology/epilepsy#benign_electroencephalographic_pattern benign electroencephalographic pattern http://purl.obolibrary.org/obo/MP_0004994 abnormal brain wave pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#paroxysmal_exercise_induced_dyskinesia paroxysmal exercise induced dyskinesia http://purl.obolibrary.org/obo/MONDO_0017657 rare paroxysmal movement disorder https://bio.scai.fraunhofer.de/ontology/epilepsy#paroxysmal_kinesigenic_dyskinesia paroxysmal kinesigenic dyskinesia http://purl.obolibrary.org/obo/MONDO_0017657 rare paroxysmal movement disorder https://bio.scai.fraunhofer.de/ontology/epilepsy#paroxysmal_nonkinesigenic_dyskinesia paroxysmal nonkinesigenic dyskinesia http://purl.obolibrary.org/obo/MONDO_0017657 rare paroxysmal movement disorder http://purl.obolibrary.org/obo/MONDO_0019487 epilepsy with myoclonic absences http://purl.obolibrary.org/obo/MONDO_0020072 childhood-onset epilepsy syndrome http://purl.obolibrary.org/obo/DOID_2538 Landau-Kleffner syndrome http://purl.obolibrary.org/obo/MONDO_0020072 childhood-onset epilepsy syndrome http://purl.obolibrary.org/obo/DOID_3329 benign epilepsy with centrotemporal spikes http://purl.obolibrary.org/obo/MONDO_0020072 childhood-onset epilepsy syndrome https://bio.scai.fraunhofer.de/ontology/epilepsy#Panayiotopoulos_syndrome Panayiotopoulos syndrome http://purl.obolibrary.org/obo/MONDO_0020072 childhood-onset epilepsy syndrome https://bio.scai.fraunhofer.de/ontology/epilepsy#epileptic_encephalopathy_with_continous_spikes_and_wave_during_sleep epileptic encephalopathy with continous spikes and wave during sleep http://purl.obolibrary.org/obo/MONDO_0020072 childhood-onset epilepsy syndrome https://bio.scai.fraunhofer.de/ontology/epilepsy#language_regression_due_to_other_etiology language regression due to other etiology http://purl.obolibrary.org/obo/MONDO_0020072 childhood-onset epilepsy syndrome http://purl.obolibrary.org/obo/MONDO_0014633 myoclonic-atonic epilepsy http://purl.obolibrary.org/obo/MONDO_0020072 childhood-onset epilepsy syndrome http://purl.obolibrary.org/obo/MONDO_0019385 steroid-responsive encephalopathy associated with autoimmune thyroiditis http://purl.obolibrary.org/obo/MONDO_0100029 antibody mediated epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#AMPA_receptor_antibody AMPA receptor antibody http://purl.obolibrary.org/obo/MONDO_0100029 antibody mediated epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#GABA-B_receptor_antibody GABA-B receptor antibody http://purl.obolibrary.org/obo/MONDO_0100029 antibody mediated epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#GAD65_antibody GAD65 antibody http://purl.obolibrary.org/obo/MONDO_0100029 antibody mediated epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#voltage-gated_potassium_channel_antibody voltage-gated potassium channel antibody http://purl.obolibrary.org/obo/MONDO_0100029 antibody mediated epilepsy http://purl.obolibrary.org/obo/DOID_308 early myoclonic encephalopathy http://purl.obolibrary.org/obo/MONDO_0100022 neonatal/infantile epilepsy syndrome http://purl.obolibrary.org/obo/MONDO_0019486 myoclonic epilepsy of infancy http://purl.obolibrary.org/obo/MONDO_0100022 neonatal/infantile epilepsy syndrome https://bio.scai.fraunhofer.de/ontology/epilepsy#self-limited_familial_and_non-familial_infantile_epilepsy self-limited familial and non-familial infantile epilepsy http://purl.obolibrary.org/obo/MONDO_0100022 neonatal/infantile epilepsy syndrome https://bio.scai.fraunhofer.de/ontology/epilepsy#self-limited_neonatal_seizure_and_self-limited_familial_neonatal_epilepsy self-limited neonatal seizure and self-limited familial neonatal epilepsy http://purl.obolibrary.org/obo/MONDO_0100022 neonatal/infantile epilepsy syndrome http://purl.obolibrary.org/obo/PATO_0002062 physical quality of a process http://purl.obolibrary.org/obo/PATO_0001236 process quality https://bio.scai.fraunhofer.de/ontology/0000511 pre-ictal http://purl.obolibrary.org/obo/PATO_0001912 physiological state https://bio.scai.fraunhofer.de/ontology/0000513 inter-ictal http://purl.obolibrary.org/obo/PATO_0001912 physiological state https://bio.scai.fraunhofer.de/ontology/epilepsy#post-ictal post-ictal http://purl.obolibrary.org/obo/PATO_0001912 physiological state http://purl.obolibrary.org/obo/NBO_0000476 intrinsic sleep disorder http://purl.obolibrary.org/obo/NBO_0000475 dyssomnia http://purl.obolibrary.org/obo/OMIT_0013780 Sleep Deprivation http://purl.obolibrary.org/obo/NBO_0000475 dyssomnia https://bio.scai.fraunhofer.de/ontology/epilepsy#pseudostatus_epilepticus pseudostatus epilepticus http://purl.obolibrary.org/obo/NBO_0000687 psychogenic non-epileptic seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#genital_automatism genital automatism http://purl.obolibrary.org/obo/NBO_0000705 automatism https://bio.scai.fraunhofer.de/ontology/epilepsy#sucking sucking http://purl.obolibrary.org/obo/NBO_0000705 automatism http://purl.obolibrary.org/obo/OMIT_0006305 Exercise Therapy http://purl.obolibrary.org/obo/NCIT_C15315 Rehabilitation http://purl.obolibrary.org/obo/OMIT_0013955 Speech Therapy http://purl.obolibrary.org/obo/NCIT_C15315 Rehabilitation https://bio.scai.fraunhofer.de/ontology/epilepsy#infectious_cause_of_seizure infectious cause of seizure http://purl.obolibrary.org/obo/NCIT_C17103 Risk Factor https://bio.scai.fraunhofer.de/ontology/epilepsy#perinatal_insult perinatal insult http://purl.obolibrary.org/obo/NCIT_C17103 Risk Factor https://bio.scai.fraunhofer.de/ontology/epilepsy#toxic_cause_of_seizure toxic cause of seizure http://purl.obolibrary.org/obo/NCIT_C17103 Risk Factor https://bio.scai.fraunhofer.de/ontology/epilepsy#trigger_factor_for_seizure trigger factor for seizure http://purl.obolibrary.org/obo/NCIT_C17103 Risk Factor https://bio.scai.fraunhofer.de/ontology/epilepsy#metallic_taste_hallucination metallic taste hallucination http://purl.obolibrary.org/obo/NCIT_C118177 Gustatory Hallucination http://purl.obolibrary.org/obo/OMIT_0005305 Diet Therapy http://purl.obolibrary.org/obo/NCIT_C65017 Nutritional Therapy http://purl.obolibrary.org/obo/OMIT_0027154 Brain Waves http://purl.obolibrary.org/obo/OBI_0002186 electroencephalography https://bio.scai.fraunhofer.de/ontology/0000512 stereotactic electroencephalogaphy http://purl.obolibrary.org/obo/OBI_0002186 electroencephalography https://bio.scai.fraunhofer.de/ontology/epilepsy#ambulatory_electroencephalography ambulatory electroencephalography http://purl.obolibrary.org/obo/OBI_0002186 electroencephalography https://bio.scai.fraunhofer.de/ontology/epilepsy#benign_EEG_pattern benign EEG pattern http://purl.obolibrary.org/obo/OBI_0002186 electroencephalography https://bio.scai.fraunhofer.de/ontology/epilepsy#conventional_electroencephalography conventional electroencephalography http://purl.obolibrary.org/obo/OBI_0002186 electroencephalography https://bio.scai.fraunhofer.de/ontology/epilepsy#normal_EEG_pattern normal EEG pattern http://purl.obolibrary.org/obo/OBI_0002186 electroencephalography https://bio.scai.fraunhofer.de/ontology/epilepsy#sleep_deprived_electroencephalography sleep deprived electroencephalography http://purl.obolibrary.org/obo/OBI_0002186 electroencephalography https://bio.scai.fraunhofer.de/ontology/epilepsy#sleep_electroencephalography sleep electroencephalography http://purl.obolibrary.org/obo/OBI_0002186 electroencephalography https://bio.scai.fraunhofer.de/ontology/epilepsy#video_telemetry video telemetry http://purl.obolibrary.org/obo/OBI_0002186 electroencephalography https://bio.scai.fraunhofer.de/ontology/epilepsy#interictal_dysphoric_disorder interictal dysphoric disorder http://purl.obolibrary.org/obo/MONDO_0002025 psychiatric disorder http://purl.obolibrary.org/obo/MONDO_0005433 alcohol withdrawal http://purl.obolibrary.org/obo/MONDO_0005567 substance withdrawal syndrome http://purl.obolibrary.org/obo/MONDO_0016701 oligoastrocytic tumor http://purl.obolibrary.org/obo/MONDO_0015917 malignant glioma http://purl.obolibrary.org/obo/DOID_3181 oligodendroglioma http://purl.obolibrary.org/obo/MONDO_0015917 malignant glioma http://purl.obolibrary.org/obo/DOID_1921 Klinefelter's syndrome http://purl.obolibrary.org/obo/MONDO_0019040 chromosomal anomaly http://purl.obolibrary.org/obo/DOID_0060407 chromosome 18q deletion syndrome http://purl.obolibrary.org/obo/MONDO_0019040 chromosomal anomaly http://purl.obolibrary.org/obo/DOID_0060410 chromosome 1p36 deletion syndrome http://purl.obolibrary.org/obo/MONDO_0019040 chromosomal anomaly https://bio.scai.fraunhofer.de/ontology/epilepsy#reading_epilepsy reading epilepsy http://purl.obolibrary.org/obo/DOID_2548 reflex epilepsy http://purl.obolibrary.org/obo/DOID_4852 pleomorphic xanthoastrocytoma http://purl.obolibrary.org/obo/DOID_3069 astrocytoma https://bio.scai.fraunhofer.de/ontology/epilepsy#left_frontal_astrocytoma left frontal astrocytoma http://purl.obolibrary.org/obo/DOID_3069 astrocytoma http://purl.obolibrary.org/obo/DOID_409 liver disease http://purl.obolibrary.org/obo/DOID_28 endocrine system disease http://purl.obolibrary.org/obo/HP_0001507 Growth abnormality http://purl.obolibrary.org/obo/HP_0000118 Phenotypic abnormality http://purl.obolibrary.org/obo/HP_0001939 Abnormality of metabolism/homeostasis http://purl.obolibrary.org/obo/HP_0000118 Phenotypic abnormality http://purl.obolibrary.org/obo/HP_0025031 Abnormality of the digestive system http://purl.obolibrary.org/obo/HP_0000118 Phenotypic abnormality https://bio.scai.fraunhofer.de/ontology/epilepsy#eye_rotation eye rotation http://purl.obolibrary.org/obo/HP_0000496 Abnormality of eye movement https://bio.scai.fraunhofer.de/ontology/epilepsy#occular_oscillation occular oscillation http://purl.obolibrary.org/obo/HP_0000496 Abnormality of eye movement https://bio.scai.fraunhofer.de/ontology/epilepsy#negative_visual_illusion negative visual illusion http://purl.obolibrary.org/obo/HP_0000504 Abnormality of vision https://bio.scai.fraunhofer.de/ontology/epilepsy#object_distortion object distortion http://purl.obolibrary.org/obo/HP_0000504 Abnormality of vision https://bio.scai.fraunhofer.de/ontology/epilepsy#object_spatial_inclination object spatial inclination http://purl.obolibrary.org/obo/HP_0000504 Abnormality of vision https://bio.scai.fraunhofer.de/ontology/epilepsy#palinopsia palinopsia http://purl.obolibrary.org/obo/HP_0000504 Abnormality of vision https://bio.scai.fraunhofer.de/ontology/epilepsy#pelopsia pelopsia http://purl.obolibrary.org/obo/HP_0000504 Abnormality of vision http://purl.obolibrary.org/obo/HP_0001123 Visual field defect http://purl.obolibrary.org/obo/HP_0000505 Visual impairment http://purl.obolibrary.org/obo/HP_0008373 Puberty and gonadal disorders http://purl.obolibrary.org/obo/HP_0000818 Abnormality of the endocrine system http://purl.obolibrary.org/obo/HP_0012668 Vasovagal syncope http://purl.obolibrary.org/obo/HP_0001279 Syncope https://bio.scai.fraunhofer.de/ontology/epilepsy#compulsive_valsalva compulsive valsalva http://purl.obolibrary.org/obo/HP_0001279 Syncope https://bio.scai.fraunhofer.de/ontology/epilepsy#hyper-cyanotic_spell hyper-cyanotic spell http://purl.obolibrary.org/obo/HP_0001279 Syncope https://bio.scai.fraunhofer.de/ontology/epilepsy#hyperventilation_syncope hyperventilation syncope http://purl.obolibrary.org/obo/HP_0001279 Syncope https://bio.scai.fraunhofer.de/ontology/epilepsy#neurological_syncope neurological syncope http://purl.obolibrary.org/obo/HP_0001279 Syncope http://purl.obolibrary.org/obo/HP_0030178 Abnormality of central nervous system electrophysiology http://purl.obolibrary.org/obo/HP_0001311 Abnormal nervous system electrophysiology http://purl.obolibrary.org/obo/HP_0002795 Functional respiratory abnormality http://purl.obolibrary.org/obo/HP_0002086 Abnormality of the respiratory system https://bio.scai.fraunhofer.de/ontology/epilepsy#generalized_motor_onset_seizure generalized motor onset seizure http://purl.obolibrary.org/obo/HP_0002197 Generalized-onset seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#generalized_non-motor_onset_seizure generalized non-motor onset seizure http://purl.obolibrary.org/obo/HP_0002197 Generalized-onset seizure http://purl.obolibrary.org/obo/HP_0006813 Hemiclonic seizures http://purl.obolibrary.org/obo/HP_0002266 Focal clonic seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#frontal_intermittent_rhythmic_delta_activity frontal intermittent rhythmic delta activity http://purl.obolibrary.org/obo/HP_0002353 EEG abnormality https://bio.scai.fraunhofer.de/ontology/epilepsy#occipital_intermittent_rhythmic_delta_activity occipital intermittent rhythmic delta activity http://purl.obolibrary.org/obo/HP_0002353 EEG abnormality https://bio.scai.fraunhofer.de/ontology/epilepsy#special_pattern special pattern http://purl.obolibrary.org/obo/HP_0002353 EEG abnormality http://purl.obolibrary.org/obo/HP_0011276 Vascular skin abnormality http://purl.obolibrary.org/obo/HP_0011354 Generalized abnormality of skin http://purl.obolibrary.org/obo/HP_0100659 Abnormality of the cerebral vasculature http://purl.obolibrary.org/obo/HP_0012443 Abnormality of brain morphology http://purl.obolibrary.org/obo/HP_0025015 Abnormal vascular morphology http://purl.obolibrary.org/obo/HP_0002597 Abnormality of the vasculature http://purl.obolibrary.org/obo/HP_0032251 Abnormal immune system morphology http://purl.obolibrary.org/obo/HP_0002715 Abnormality of the immune system https://bio.scai.fraunhofer.de/ontology/epilepsy#extensor_spasm extensor spasm http://purl.obolibrary.org/obo/HP_0003394 Muscle spasm https://bio.scai.fraunhofer.de/ontology/epilepsy#flexor_spasm flexor spasm http://purl.obolibrary.org/obo/HP_0003394 Muscle spasm https://bio.scai.fraunhofer.de/ontology/epilepsy#mixed_spasm mixed spasm http://purl.obolibrary.org/obo/HP_0003394 Muscle spasm https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_seizure_classification_by_onset_feature focal seizure classification by onset feature http://purl.obolibrary.org/obo/HP_0007359 Focal-onset seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_to_bilateral_tonic_clonic_seizure focal to bilateral tonic clonic seizure http://purl.obolibrary.org/obo/HP_0007359 Focal-onset seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#seizure_based_on_hemispheric_lateralization seizure based on hemispheric lateralization http://purl.obolibrary.org/obo/HP_0007359 Focal-onset seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#seizure_based_on_lobar_localization seizure based on lobar localization http://purl.obolibrary.org/obo/HP_0007359 Focal-onset seizure http://purl.obolibrary.org/obo/HP_0011021 Abnormality of circulating enzyme level http://purl.obolibrary.org/obo/HP_0010876 Abnormal circulating protein level http://purl.obolibrary.org/obo/HP_0011166 Focal myoclonic seizures http://purl.obolibrary.org/obo/HP_0011153 Focal motor seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_automatism_seizure focal automatism seizure http://purl.obolibrary.org/obo/HP_0011153 Focal motor seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_bilateral_motor_seizure focal bilateral motor seizure http://purl.obolibrary.org/obo/HP_0011153 Focal motor seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_motor_seizure_with_dysarthria_/_anarthria focal motor seizure with dysarthria / anarthria http://purl.obolibrary.org/obo/HP_0011153 Focal motor seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_motor_seizure_with_dystonia focal motor seizure with dystonia http://purl.obolibrary.org/obo/HP_0011153 Focal motor seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_motor_seizure_with_negative_myoclonus focal motor seizure with negative myoclonus http://purl.obolibrary.org/obo/HP_0011153 Focal motor seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_motor_seizure_with_paresis/paralysis focal motor seizure with paresis/paralysis http://purl.obolibrary.org/obo/HP_0011153 Focal motor seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_motor_seizure_with_version focal motor seizure with version http://purl.obolibrary.org/obo/HP_0011153 Focal motor seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#ictal_pattern ictal pattern http://purl.obolibrary.org/obo/HP_0011198 EEG with generalized epileptiform discharges http://purl.obolibrary.org/obo/HP_0002167 Neurological speech impairment http://purl.obolibrary.org/obo/HP_0011446 Abnormality of higher mental function http://purl.obolibrary.org/obo/HP_0004372 Reduced consciousness/confusion http://purl.obolibrary.org/obo/HP_0011446 Abnormality of higher mental function http://purl.obolibrary.org/obo/HP_0002017 Nausea and vomiting http://purl.obolibrary.org/obo/HP_0011458 Abdominal symptom http://purl.obolibrary.org/obo/HP_0003808 Abnormal muscle tone http://purl.obolibrary.org/obo/HP_0011804 Abnormal muscle physiology http://purl.obolibrary.org/obo/HP_0004329 Abnormal posterior eye segment morphology http://purl.obolibrary.org/obo/HP_0012372 Abnormal eye morphology http://purl.obolibrary.org/obo/BFO_0000008 temporal region http://purl.obolibrary.org/obo/BFO_0000003 occurrent http://purl.obolibrary.org/obo/BFO_0000011 spatiotemporal region http://purl.obolibrary.org/obo/BFO_0000003 occurrent http://purl.obolibrary.org/obo/BFO_0000040 material entity http://purl.obolibrary.org/obo/BFO_0000004 independent continuant http://purl.obolibrary.org/obo/BFO_0000141 immaterial entity http://purl.obolibrary.org/obo/BFO_0000004 independent continuant http://purl.obolibrary.org/obo/BFO_0000009 two-dimensional spatial region http://purl.obolibrary.org/obo/BFO_0000006 spatial region http://purl.obolibrary.org/obo/BFO_0000018 zero-dimensional spatial region http://purl.obolibrary.org/obo/BFO_0000006 spatial region http://purl.obolibrary.org/obo/BFO_0000026 one-dimensional spatial region http://purl.obolibrary.org/obo/BFO_0000006 spatial region http://purl.obolibrary.org/obo/BFO_0000028 three-dimensional spatial region http://purl.obolibrary.org/obo/BFO_0000006 spatial region http://purl.obolibrary.org/obo/BFO_0000038 one-dimensional temporal region http://purl.obolibrary.org/obo/BFO_0000008 temporal region http://purl.obolibrary.org/obo/BFO_0000182 history http://purl.obolibrary.org/obo/BFO_0000015 process http://purl.obolibrary.org/obo/BFO_0000034 function http://purl.obolibrary.org/obo/BFO_0000016 disposition http://purl.obolibrary.org/obo/OGMS_0000032 homeostasis http://purl.obolibrary.org/obo/BFO_0000016 disposition http://purl.obolibrary.org/obo/BFO_0000016 disposition http://purl.obolibrary.org/obo/BFO_0000017 realizable entity http://purl.obolibrary.org/obo/BFO_0000023 role http://purl.obolibrary.org/obo/BFO_0000017 realizable entity http://purl.obolibrary.org/obo/OMIT_0027103 Endophenotypes http://purl.obolibrary.org/obo/BFO_0000019 quality http://purl.obolibrary.org/obo/BFO_0000017 realizable entity http://purl.obolibrary.org/obo/BFO_0000020 specifically dependent continuant http://purl.obolibrary.org/obo/BFO_0000019 quality http://purl.obolibrary.org/obo/BFO_0000020 specifically dependent continuant https://bio.scai.fraunhofer.de/ontology/0000500 connectivity http://purl.obolibrary.org/obo/BFO_0000031 generically dependent continuant http://purl.obolibrary.org/obo/CLO_0037307 induced pluripotent stem cell line cell http://purl.obolibrary.org/obo/BFO_0000040 material entity http://purl.obolibrary.org/obo/BFO_0000024 fiat object part http://purl.obolibrary.org/obo/BFO_0000040 material entity http://purl.obolibrary.org/obo/BFO_0000027 object aggregate http://purl.obolibrary.org/obo/BFO_0000040 material entity http://purl.obolibrary.org/obo/BFO_0000030 object http://purl.obolibrary.org/obo/BFO_0000040 material entity http://purl.obolibrary.org/obo/NCBITaxon_1 root http://purl.obolibrary.org/obo/BFO_0000040 material entity http://purl.obolibrary.org/obo/BFO_0000142 one-dimensional continuant fiat boundary http://purl.obolibrary.org/obo/BFO_0000140 continuant fiat boundary http://purl.obolibrary.org/obo/BFO_0000146 two-dimensional continuant fiat boundary http://purl.obolibrary.org/obo/BFO_0000140 continuant fiat boundary http://purl.obolibrary.org/obo/BFO_0000147 zero-dimensional continuant fiat boundary http://purl.obolibrary.org/obo/BFO_0000140 continuant fiat boundary http://purl.obolibrary.org/obo/BFO_0000006 spatial region http://purl.obolibrary.org/obo/BFO_0000141 immaterial entity http://purl.obolibrary.org/obo/BFO_0000029 site http://purl.obolibrary.org/obo/BFO_0000141 immaterial entity https://bio.scai.fraunhofer.de/ontology/0000508 functional connectivity measure http://purl.obolibrary.org/obo/IAO_0000027 data item https://bio.scai.fraunhofer.de/ontology/0000509 global connectivity measure http://purl.obolibrary.org/obo/IAO_0000027 data item http://purl.obolibrary.org/obo/CMO_0000000 clinical measurement http://purl.obolibrary.org/obo/IAO_0000109 measurement datum https://bio.scai.fraunhofer.de/ontology/epilepsy#intracranial_infection intracranial infection http://purl.obolibrary.org/obo/IDO_0000586 infection https://bio.scai.fraunhofer.de/ontology/epilepsy#parasitic_cyst parasitic cyst http://purl.obolibrary.org/obo/IDO_0000586 infection http://purl.obolibrary.org/obo/OMIT_0008783 Kidney Function Tests http://purl.obolibrary.org/obo/OBI_0000070 assay http://purl.obolibrary.org/obo/OMIT_0009194 Liver Function Tests http://purl.obolibrary.org/obo/OBI_0000070 assay http://purl.obolibrary.org/obo/NCIT_C94198 Cardiac Pacemaker http://purl.obolibrary.org/obo/OBI_0000968 device https://bio.scai.fraunhofer.de/ontology/epilepsy#non-pharmacological_treatment_of_epilepsy non-pharmacological treatment of epilepsy http://purl.obolibrary.org/obo/OGMS_0000090 treatment http://purl.obolibrary.org/obo/OMIT_0022847 Hemispherectomy http://purl.obolibrary.org/obo/OMIABIS_0001041 surgical procedure https://bio.scai.fraunhofer.de/ontology/epilepsy#anteromesial_temporal_lobectomy anteromesial temporal lobectomy http://purl.obolibrary.org/obo/OMIABIS_0001041 surgical procedure https://bio.scai.fraunhofer.de/ontology/epilepsy#corpus_callosotomy corpus callosotomy http://purl.obolibrary.org/obo/OMIABIS_0001041 surgical procedure https://bio.scai.fraunhofer.de/ontology/epilepsy#electrode_implantation electrode implantation http://purl.obolibrary.org/obo/OMIABIS_0001041 surgical procedure https://bio.scai.fraunhofer.de/ontology/epilepsy#extratemporal_cortical_resection extratemporal cortical resection http://purl.obolibrary.org/obo/OMIABIS_0001041 surgical procedure https://bio.scai.fraunhofer.de/ontology/epilepsy#left_hemisphere_tumor_resection left hemisphere tumor resection http://purl.obolibrary.org/obo/OMIABIS_0001041 surgical procedure https://bio.scai.fraunhofer.de/ontology/epilepsy#multilobar_resection multilobar resection http://purl.obolibrary.org/obo/OMIABIS_0001041 surgical procedure https://bio.scai.fraunhofer.de/ontology/epilepsy#multiple_subpial_transection multiple subpial transection http://purl.obolibrary.org/obo/OMIABIS_0001041 surgical procedure https://bio.scai.fraunhofer.de/ontology/epilepsy#selective_amygdalohippocampectomy selective amygdalohippocampectomy http://purl.obolibrary.org/obo/OMIABIS_0001041 surgical procedure http://purl.obolibrary.org/obo/OMIT_0026277 Ketogenic Diet http://purl.obolibrary.org/obo/OMIT_0005305 Diet Therapy https://bio.scai.fraunhofer.de/ontology/epilepsy#Atkins_diet Atkins diet http://purl.obolibrary.org/obo/OMIT_0005305 Diet Therapy https://bio.scai.fraunhofer.de/ontology/epilepsy#oligoantigenic_diet oligoantigenic diet http://purl.obolibrary.org/obo/OMIT_0005305 Diet Therapy https://bio.scai.fraunhofer.de/ontology/epilepsy#6_Hertz_psychomotor 6 Hertz psychomotor http://purl.obolibrary.org/obo/OMIT_0008800 Kindling model https://bio.scai.fraunhofer.de/ontology/epilepsy#corneal_kindling corneal kindling http://purl.obolibrary.org/obo/OMIT_0008800 Kindling model https://bio.scai.fraunhofer.de/ontology/epilepsy#hippocampal_kindling_model hippocampal kindling model http://purl.obolibrary.org/obo/OMIT_0008800 Kindling model http://purl.obolibrary.org/obo/OMIT_0001932 Alpha Rhythm http://purl.obolibrary.org/obo/OMIT_0027154 Brain Waves http://purl.obolibrary.org/obo/OMIT_0002976 Beta Rhythm http://purl.obolibrary.org/obo/OMIT_0027154 Brain Waves http://purl.obolibrary.org/obo/OMIT_0004981 Delta Rhythm http://purl.obolibrary.org/obo/OMIT_0027154 Brain Waves http://purl.obolibrary.org/obo/OMIT_0014676 Theta Rhythm http://purl.obolibrary.org/obo/OMIT_0027154 Brain Waves http://purl.obolibrary.org/obo/OMIT_0028745 Gamma Rhythm http://purl.obolibrary.org/obo/OMIT_0027154 Brain Waves https://bio.scai.fraunhofer.de/ontology/epilepsy#monomorphic_wave monomorphic wave http://purl.obolibrary.org/obo/OMIT_0027154 Brain Waves https://bio.scai.fraunhofer.de/ontology/epilepsy#polymorphic_wave polymorphic wave http://purl.obolibrary.org/obo/OMIT_0027154 Brain Waves https://bio.scai.fraunhofer.de/ontology/epilepsy#sinusoidal_wave sinusoidal wave http://purl.obolibrary.org/obo/OMIT_0027154 Brain Waves https://bio.scai.fraunhofer.de/ontology/epilepsy#transient transient http://purl.obolibrary.org/obo/OMIT_0027154 Brain Waves http://purl.obolibrary.org/obo/OMIT_0027689 Functional Neuroimaging http://purl.obolibrary.org/obo/OMIT_0027688 Neuroimaging https://bio.scai.fraunhofer.de/ontology/epilepsy#anatomic_neuroimaging anatomic neuroimaging http://purl.obolibrary.org/obo/OMIT_0027688 Neuroimaging https://bio.scai.fraunhofer.de/ontology/epilepsy#metabolic_imaging metabolic imaging http://purl.obolibrary.org/obo/OMIT_0027689 Functional Neuroimaging https://bio.scai.fraunhofer.de/ontology/epilepsy#rotational_horizontal rotational horizontal http://purl.obolibrary.org/obo/SYMP_0000399 vertigo https://bio.scai.fraunhofer.de/ontology/epilepsy#rotational_vertical rotational vertical http://purl.obolibrary.org/obo/SYMP_0000399 vertigo http://purl.obolibrary.org/obo/SYMP_0000449 cardiogenic shock http://purl.obolibrary.org/obo/SYMP_0000450 shock https://bio.scai.fraunhofer.de/ontology/epilepsy#partial_amnesia partial amnesia http://purl.obolibrary.org/obo/SYMP_0000719 memory impairment https://bio.scai.fraunhofer.de/ontology/epilepsy#congenital_stroke congenital stroke http://purl.obolibrary.org/obo/SYMP_0000734 stroke https://bio.scai.fraunhofer.de/ontology/epilepsy#fragmentary_behavior fragmentary behavior http://purl.obolibrary.org/obo/SYMP_0019182 behavioral symptom https://bio.scai.fraunhofer.de/ontology/epilepsy#infantile_behavior infantile behavior http://purl.obolibrary.org/obo/SYMP_0019182 behavioral symptom https://bio.scai.fraunhofer.de/ontology/epilepsy#interictal_behavior_disorder interictal behavior disorder http://purl.obolibrary.org/obo/SYMP_0019182 behavioral symptom https://bio.scai.fraunhofer.de/ontology/epilepsy#lip_smacking lip smacking http://purl.obolibrary.org/obo/SYMP_0019182 behavioral symptom https://bio.scai.fraunhofer.de/ontology/epilepsy#loss_of_awareness loss of awareness http://purl.obolibrary.org/obo/SYMP_0019182 behavioral symptom http://purl.obolibrary.org/obo/DOID_4194 glucose metabolism disease http://purl.obolibrary.org/obo/DOID_0050013 carbohydrate metabolism disease https://bio.scai.fraunhofer.de/ontology/epilepsy#right_fronto_temporal_glioma right fronto temporal glioma http://purl.obolibrary.org/obo/DOID_0060108 brain glioma http://purl.obolibrary.org/obo/MONDO_0011593 seizures, benign familial infantile, 2 http://purl.obolibrary.org/obo/DOID_0060169 benign familial infantile epilepsy http://purl.obolibrary.org/obo/DOID_0080074 neural tube defect http://purl.obolibrary.org/obo/DOID_0080015 physical disorder http://purl.obolibrary.org/obo/DOID_2490 congenital nervous system abnormality http://purl.obolibrary.org/obo/DOID_0080015 physical disorder http://purl.obolibrary.org/obo/DOID_0080016 spina bifida http://purl.obolibrary.org/obo/DOID_0080074 neural tube defect http://purl.obolibrary.org/obo/DOID_1682 congenital heart disease http://purl.obolibrary.org/obo/DOID_114 heart disease http://purl.obolibrary.org/obo/OMIT_0019508 Craniofacial Abnormalities http://purl.obolibrary.org/obo/DOID_17 musculoskeletal system disease http://purl.obolibrary.org/obo/DOID_3328 temporal lobe epilepsy http://purl.obolibrary.org/obo/DOID_1826 epilepsy http://purl.obolibrary.org/obo/DOID_3331 frontal lobe epilepsy http://purl.obolibrary.org/obo/DOID_1826 epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#epilepsy_with_general_tonic_clonic_seizure_on_awakening epilepsy with general tonic clonic seizure on awakening http://purl.obolibrary.org/obo/DOID_1826 epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#familial_(autosomal_dominant)_focal_epilepsy familial (autosomal dominant) focal epilepsy http://purl.obolibrary.org/obo/DOID_1826 epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#multifocal_epilepsy multifocal epilepsy http://purl.obolibrary.org/obo/DOID_1826 epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#occipital_lobe_epilepsy occipital lobe epilepsy http://purl.obolibrary.org/obo/DOID_1826 epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#parieto_occipital_epilepsy parieto occipital epilepsy http://purl.obolibrary.org/obo/DOID_1826 epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#simple_focal_seizure simple focal seizure http://purl.obolibrary.org/obo/DOID_1826 epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#symptomatic_epilepsy symptomatic epilepsy http://purl.obolibrary.org/obo/DOID_1826 epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#temporo_occipital_epilepsy temporo occipital epilepsy http://purl.obolibrary.org/obo/DOID_1826 epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#temporo_parietal_epilepsy temporo parietal epilepsy http://purl.obolibrary.org/obo/DOID_1826 epilepsy http://purl.obolibrary.org/obo/MONDO_0015657 inflammatory and autoimmune disease with epilepsy http://purl.obolibrary.org/obo/DOID_1826 epilepsy http://purl.obolibrary.org/obo/MONDO_0015659 infectious disease with epilepsy http://purl.obolibrary.org/obo/DOID_1826 epilepsy http://purl.obolibrary.org/obo/MONDO_0015654 idiopathic or cryptogenic familial epilepsy syndrome with identified loci/genes http://purl.obolibrary.org/obo/DOID_1826 epilepsy http://purl.obolibrary.org/obo/MONDO_0018200 acute encephalopathy with inflammation-mediated status epilepticus http://purl.obolibrary.org/obo/MONDO_0015657 inflammatory and autoimmune disease with epilepsy http://purl.obolibrary.org/obo/MONDO_0020070 neonatal epilepsy syndrome http://purl.obolibrary.org/obo/DOID_225 syndrome http://purl.obolibrary.org/obo/MONDO_0019485 idiopathic hemiconvulsion-hemiplegia syndrome http://purl.obolibrary.org/obo/MONDO_0018200 acute encephalopathy with inflammation-mediated status epilepticus https://bio.scai.fraunhofer.de/ontology/epilepsy#SCN8A-related_epilepsy_with_encephalopathy SCN8A-related epilepsy with encephalopathy http://purl.obolibrary.org/obo/DOID_225 syndrome http://purl.obolibrary.org/obo/SYMP_0000022 depression http://purl.obolibrary.org/obo/DOID_2468 psychotic disorder http://purl.obolibrary.org/obo/DOID_5393 brain angioma http://purl.obolibrary.org/obo/DOID_936 brain disease http://purl.obolibrary.org/obo/DOID_319 spinal cord disease http://purl.obolibrary.org/obo/DOID_331 central nervous system disease https://bio.scai.fraunhofer.de/ontology/epilepsy#amgdalar_epilepsy amgdalar epilepsy http://purl.obolibrary.org/obo/DOID_3328 temporal lobe epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#anterior_temporal_epilepsy anterior temporal epilepsy http://purl.obolibrary.org/obo/DOID_3328 temporal lobe epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#basal_temporal_epilepsy basal temporal epilepsy http://purl.obolibrary.org/obo/DOID_3328 temporal lobe epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#hippocampal_epilepsy hippocampal epilepsy http://purl.obolibrary.org/obo/DOID_3328 temporal lobe epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#parahippocampal_epilepsy parahippocampal epilepsy http://purl.obolibrary.org/obo/DOID_3328 temporal lobe epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#posterior_temporal_epilepsy posterior temporal epilepsy http://purl.obolibrary.org/obo/DOID_3328 temporal lobe epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#lateral_frontal_epilepsy lateral frontal epilepsy http://purl.obolibrary.org/obo/DOID_3331 frontal lobe epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#mesial_frontal_epilepsy mesial frontal epilepsy http://purl.obolibrary.org/obo/DOID_3331 frontal lobe epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#orbito_frontal_epilepsy orbito frontal epilepsy http://purl.obolibrary.org/obo/DOID_3331 frontal lobe epilepsy http://purl.obolibrary.org/obo/DOID_4248 coronary stenosis http://purl.obolibrary.org/obo/DOID_3393 coronary artery disease https://bio.scai.fraunhofer.de/ontology/epilepsy#autoimmune_epilepsy autoimmune epilepsy http://purl.obolibrary.org/obo/DOID_4 disease http://purl.obolibrary.org/obo/MONDO_0017656 motor stereotypies http://purl.obolibrary.org/obo/DOID_480 movement disease http://purl.obolibrary.org/obo/MONDO_0016058 paroxysmal dystonia http://purl.obolibrary.org/obo/DOID_480 movement disease http://purl.obolibrary.org/obo/SYMP_0000585 sleep related movement disorder http://purl.obolibrary.org/obo/DOID_535 sleep disorder https://bio.scai.fraunhofer.de/ontology/epilepsy#benign_neonatal_sleep_myoclonus benign neonatal sleep myoclonus http://purl.obolibrary.org/obo/DOID_535 sleep disorder https://bio.scai.fraunhofer.de/ontology/epilepsy#hypnogogic_jerk hypnogogic jerk http://purl.obolibrary.org/obo/DOID_535 sleep disorder https://bio.scai.fraunhofer.de/ontology/epilepsy#situational_cicardian_rhythm_sleep_disorder situational cicardian rhythm sleep disorder http://purl.obolibrary.org/obo/DOID_535 sleep disorder https://bio.scai.fraunhofer.de/ontology/epilepsy#aluminum_encephalopathy_syndrome aluminum encephalopathy syndrome http://purl.obolibrary.org/obo/DOID_557 kidney disease https://bio.scai.fraunhofer.de/ontology/epilepsy#uremic_encephalopathy uremic encephalopathy http://purl.obolibrary.org/obo/DOID_557 kidney disease http://purl.obolibrary.org/obo/DOID_9335 scotoma http://purl.obolibrary.org/obo/DOID_5614 eye disease http://purl.obolibrary.org/obo/DOID_11465 autonomic nervous system disease http://purl.obolibrary.org/obo/DOID_574 peripheral nervous system disease http://purl.obolibrary.org/obo/MONDO_0007530 electroencephalographic peculiarity: 14 and 6 per sec. positive spike phenomenon http://purl.obolibrary.org/obo/DOID_630 genetic disease http://purl.obolibrary.org/obo/OMIT_0027574 Cerebral Small Vessel Diseases http://purl.obolibrary.org/obo/DOID_6713 cerebrovascular disease http://purl.obolibrary.org/obo/DOID_8534 gastroesophageal reflux disease http://purl.obolibrary.org/obo/DOID_77 gastrointestinal system disease http://purl.obolibrary.org/obo/MONDO_0015916 rare neuroinflammatory or neuroimmunological disease http://purl.obolibrary.org/obo/DOID_863 nervous system disease http://purl.obolibrary.org/obo/DOID_10907 microcephaly http://purl.obolibrary.org/obo/DOID_936 brain disease https://bio.scai.fraunhofer.de/ontology/epilepsy#bifocal_encephalomalacia bifocal encephalomalacia http://purl.obolibrary.org/obo/DOID_936 brain disease https://bio.scai.fraunhofer.de/ontology/epilepsy#left_mesial_temporal_lesion left mesial temporal lesion http://purl.obolibrary.org/obo/DOID_936 brain disease https://bio.scai.fraunhofer.de/ontology/epilepsy#right_frontal_encephalomalacia right frontal encephalomalacia http://purl.obolibrary.org/obo/DOID_936 brain disease https://bio.scai.fraunhofer.de/ontology/epilepsy#right_hemispheric_stroke right hemispheric stroke http://purl.obolibrary.org/obo/DOID_936 brain disease https://bio.scai.fraunhofer.de/ontology/epilepsy#right_mesial_lesion right mesial lesion http://purl.obolibrary.org/obo/DOID_936 brain disease http://purl.obolibrary.org/obo/MONDO_0016292 nodular neuronal heterotopia http://purl.obolibrary.org/obo/DOID_936 brain disease http://purl.obolibrary.org/obo/DOID_14503 neuronal ceroid lipofuscinosis http://purl.obolibrary.org/obo/DOID_9455 lipid storage disease http://purl.obolibrary.org/obo/HP_0000315 Abnormality of the orbital region http://purl.obolibrary.org/obo/HP_0000271 Abnormality of the face http://purl.obolibrary.org/obo/HP_0011799 Abnormality of facial soft tissue http://purl.obolibrary.org/obo/HP_0000271 Abnormality of the face http://purl.obolibrary.org/obo/CLO_0037199 小鼠DBA/2近交系 http://purl.obolibrary.org/obo/NCBITaxon_10090 Mus musculus http://purl.obolibrary.org/obo/RS_0000457 rat strain http://purl.obolibrary.org/obo/NCBITaxon_10116 Rattus norvegicus https://bio.scai.fraunhofer.de/ontology/epilepsy#unworthiness unworthiness http://purl.obolibrary.org/obo/MFOEM_000001 emotion process https://bio.scai.fraunhofer.de/ontology/epilepsy#worthiness worthiness http://purl.obolibrary.org/obo/MFOEM_000001 emotion process http://purl.obolibrary.org/obo/MFOEM_000014 rage http://purl.obolibrary.org/obo/MFOEM_000009 anger http://purl.obolibrary.org/obo/MFOEM_000027 terror http://purl.obolibrary.org/obo/MFOEM_000026 fear http://purl.obolibrary.org/obo/MONDO_0015642 benign partial infantile seizures http://purl.obolibrary.org/obo/MONDO_0020071 infantile epilepsy syndrome https://bio.scai.fraunhofer.de/ontology/epilepsy#temporal_intermittent_rythmic_delta_activity temporal intermittent rythmic delta activity http://purl.obolibrary.org/obo/HP_0010845 EEG with generalized slow activity https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_autonomic_seizure_with_epigastric_sensation_or_with_nausea_/_vomiting focal autonomic seizure with epigastric sensation or with nausea / vomiting http://purl.obolibrary.org/obo/HP_0011154 Focal autonomic seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_autonomic_seizure_with_erection focal autonomic seizure with erection http://purl.obolibrary.org/obo/HP_0011154 Focal autonomic seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_autonomic_seizure_with_hypoventilation/hyperventilation/altered_respiration focal autonomic seizure with hypoventilation/hyperventilation/altered respiration http://purl.obolibrary.org/obo/HP_0011154 Focal autonomic seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_autonomic_seizure_with_lacrimation focal autonomic seizure with lacrimation http://purl.obolibrary.org/obo/HP_0011154 Focal autonomic seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_autonomic_seizure_with_pallor/flushing focal autonomic seizure with pallor/flushing http://purl.obolibrary.org/obo/HP_0011154 Focal autonomic seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_autonomic_seizure_with_palpitation/tachycardia_/bradycardia/asystole focal autonomic seizure with palpitation/tachycardia /bradycardia/asystole http://purl.obolibrary.org/obo/HP_0011154 Focal autonomic seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_autonomic_seizure_with_piloerection focal autonomic seizure with piloerection http://purl.obolibrary.org/obo/HP_0011154 Focal autonomic seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_autonomic_seizure_with_pupillary_dilation/constriction focal autonomic seizure with pupillary dilation/constriction http://purl.obolibrary.org/obo/HP_0011154 Focal autonomic seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_autonomic_seizure_with_urge_to_urinate/defecate focal autonomic seizure with urge to urinate/defecate http://purl.obolibrary.org/obo/HP_0011154 Focal autonomic seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_sensory_seizure_with_cephalic_sensation focal sensory seizure with cephalic sensation http://purl.obolibrary.org/obo/HP_0011157 Focal sensory seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_sensory_seizure_with_hot-cold_sensation focal sensory seizure with hot-cold sensation http://purl.obolibrary.org/obo/HP_0011157 Focal sensory seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_sensory_vestibular_seizure focal sensory vestibular seizure http://purl.obolibrary.org/obo/HP_0011157 Focal sensory seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#adversive_movement adversive movement http://purl.obolibrary.org/obo/HP_0011175 Versive seizures https://bio.scai.fraunhofer.de/ontology/epilepsy#twisting twisting http://purl.obolibrary.org/obo/HP_0011175 Versive seizures https://bio.scai.fraunhofer.de/ontology/epilepsy#background_slow_activity background slow activity http://purl.obolibrary.org/obo/HP_0011203 EEG with abnormally slow frequencies https://bio.scai.fraunhofer.de/ontology/epilepsy#intermittent_slow_activity intermittent slow activity http://purl.obolibrary.org/obo/HP_0011203 EEG with abnormally slow frequencies http://purl.obolibrary.org/obo/NCBITaxon_131567 cellular organisms http://purl.obolibrary.org/obo/NCBITaxon_1 root http://purl.obolibrary.org/obo/NCBITaxon_2759 Eukaryota http://purl.obolibrary.org/obo/NCBITaxon_131567 cellular organisms http://purl.obolibrary.org/obo/NCBITaxon_6157 Platyhelminthes http://purl.obolibrary.org/obo/NCBITaxon_2759 Eukaryota http://purl.obolibrary.org/obo/NCBITaxon_6231 Nematoda http://purl.obolibrary.org/obo/NCBITaxon_2759 Eukaryota http://purl.obolibrary.org/obo/NCBITaxon_6656 Arthropoda http://purl.obolibrary.org/obo/NCBITaxon_2759 Eukaryota http://purl.obolibrary.org/obo/NCBITaxon_7742 Vertebrata http://purl.obolibrary.org/obo/NCBITaxon_2759 Eukaryota http://purl.obolibrary.org/obo/NCBITaxon_9989 Rodentia http://purl.obolibrary.org/obo/NCBITaxon_40674 Mammalia http://purl.obolibrary.org/obo/NCBITaxon_9443 Primates http://purl.obolibrary.org/obo/NCBITaxon_40674 Mammalia http://purl.obolibrary.org/obo/NCBITaxon_6204 Taenia solium http://purl.obolibrary.org/obo/NCBITaxon_6157 Platyhelminthes http://purl.obolibrary.org/obo/NCBITaxon_6239 Caenorhabditis elegans http://purl.obolibrary.org/obo/NCBITaxon_6231 Nematoda http://purl.obolibrary.org/obo/NCBITaxon_7227 Drosophila melanogaster http://purl.obolibrary.org/obo/NCBITaxon_6656 Arthropoda http://purl.obolibrary.org/obo/NCBITaxon_40674 Mammalia http://purl.obolibrary.org/obo/NCBITaxon_7742 Vertebrata http://purl.obolibrary.org/obo/NCBITaxon_8292 Amphibia http://purl.obolibrary.org/obo/NCBITaxon_7742 Vertebrata http://purl.obolibrary.org/obo/NCBITaxon_10090 Mus musculus http://purl.obolibrary.org/obo/NCBITaxon_9989 Rodentia http://purl.obolibrary.org/obo/NCBITaxon_10116 Rattus norvegicus http://purl.obolibrary.org/obo/NCBITaxon_9989 Rodentia http://purl.obolibrary.org/obo/NCBITaxon_10047 Meriones unguiculatus http://purl.obolibrary.org/obo/NCBITaxon_9989 Rodentia http://purl.obolibrary.org/obo/UBERON_0034944 zone of organ http://purl.obolibrary.org/obo/UBERON_0000064 organ part http://purl.obolibrary.org/obo/FMA_242176 Broca's area http://purl.obolibrary.org/obo/UBERON_0000956 cerebral cortex http://purl.obolibrary.org/obo/OMIT_0007783 Hippocampus http://purl.obolibrary.org/obo/UBERON_0000956 cerebral cortex http://purl.obolibrary.org/obo/FMA_71055 Supracalcarine cortex (SCAL) http://purl.obolibrary.org/obo/UBERON_0000956 cerebral cortex https://bio.scai.fraunhofer.de/ontology/epilepsy#anterior_frontopolar_cortex anterior frontopolar cortex http://purl.obolibrary.org/obo/UBERON_0000956 cerebral cortex https://bio.scai.fraunhofer.de/ontology/epilepsy#brain_junction brain junction http://purl.obolibrary.org/obo/UBERON_0000956 cerebral cortex http://purl.obolibrary.org/obo/UBERON_0019264 gray matter of forebrain http://purl.obolibrary.org/obo/UBERON_0003528 brain gray matter http://purl.obolibrary.org/obo/UBERON_0019294 commissure of telencephalon http://purl.obolibrary.org/obo/UBERON_0005970 brain commissure http://purl.obolibrary.org/obo/UBERON_0006794 visual processing part of nervous system http://purl.obolibrary.org/obo/UBERON_0011216 organ system subdivision http://purl.obolibrary.org/obo/UBERON_0035927 sulcus of parietal lobe http://purl.obolibrary.org/obo/UBERON_0013118 sulcus of brain http://purl.obolibrary.org/obo/UBERON_0008334 subarachnoid sulcus http://purl.obolibrary.org/obo/UBERON_0013118 sulcus of brain http://purl.obolibrary.org/obo/UBERON_0019303 occipital sulcus http://purl.obolibrary.org/obo/UBERON_0013118 sulcus of brain http://purl.obolibrary.org/obo/UBERON_0013533 Brodmann (1909) area 2 http://purl.obolibrary.org/obo/UBERON_0013529 Brodmann area http://purl.obolibrary.org/obo/UBERON_0025096 superior calcarine sulcus http://purl.obolibrary.org/obo/UBERON_0019303 occipital sulcus http://purl.obolibrary.org/obo/UBERON_0022776 composite part spanning multiple base regional parts of brain http://purl.obolibrary.org/obo/UBERON_0034925 anatomical collection http://purl.obolibrary.org/obo/CMO_0000001 cardiovascular measurement http://purl.obolibrary.org/obo/CMO_0000000 clinical measurement http://purl.obolibrary.org/obo/CMO_0000021 body morphological measurement http://purl.obolibrary.org/obo/CMO_0000000 clinical measurement http://purl.obolibrary.org/obo/CMO_0000035 blood measurement http://purl.obolibrary.org/obo/CMO_0000000 clinical measurement http://purl.obolibrary.org/obo/CMO_0000094 respiratory system measurement http://purl.obolibrary.org/obo/CMO_0000000 clinical measurement http://purl.obolibrary.org/obo/CMO_0000227 cell measurement http://purl.obolibrary.org/obo/CMO_0000000 clinical measurement http://purl.obolibrary.org/obo/CMO_0001232 nervous system measurement http://purl.obolibrary.org/obo/CMO_0000000 clinical measurement http://purl.obolibrary.org/obo/CMO_0000294 pulse http://purl.obolibrary.org/obo/CMO_0000001 cardiovascular measurement http://purl.obolibrary.org/obo/CMO_0000670 heart measurement http://purl.obolibrary.org/obo/CMO_0000001 cardiovascular measurement http://purl.obolibrary.org/obo/CMO_0000182 head morphological measurement http://purl.obolibrary.org/obo/CMO_0000021 body morphological measurement http://purl.obolibrary.org/obo/CMO_0000296 abdominal morphological measurement http://purl.obolibrary.org/obo/CMO_0000021 body morphological measurement http://purl.obolibrary.org/obo/CMO_0000028 blood protein measurement http://purl.obolibrary.org/obo/CMO_0000023 blood chemistry measurement http://purl.obolibrary.org/obo/CMO_0000046 blood glucose level http://purl.obolibrary.org/obo/CMO_0000023 blood chemistry measurement http://purl.obolibrary.org/obo/CMO_0000063 blood electrolyte measurement http://purl.obolibrary.org/obo/CMO_0000023 blood chemistry measurement http://purl.obolibrary.org/obo/CMO_0001303 blood lactate level http://purl.obolibrary.org/obo/CMO_0000023 blood chemistry measurement http://purl.obolibrary.org/obo/CMO_0001924 blood cytokine measurement http://purl.obolibrary.org/obo/CMO_0000028 blood protein measurement http://purl.obolibrary.org/obo/CMO_0002498 blood enzyme measurement http://purl.obolibrary.org/obo/CMO_0000028 blood protein measurement http://purl.obolibrary.org/obo/CMO_0000023 blood chemistry measurement http://purl.obolibrary.org/obo/CMO_0000035 blood measurement http://purl.obolibrary.org/obo/CMO_0000036 blood cell measurement http://purl.obolibrary.org/obo/CMO_0000227 cell measurement http://purl.obolibrary.org/obo/CMO_0000508 hemoglobin measurement http://purl.obolibrary.org/obo/CMO_0000036 blood cell measurement http://purl.obolibrary.org/obo/CMO_0000921 platelet measurement http://purl.obolibrary.org/obo/CMO_0000036 blood cell measurement http://purl.obolibrary.org/obo/CMO_0001356 red blood cell measurement http://purl.obolibrary.org/obo/CMO_0000036 blood cell measurement http://purl.obolibrary.org/obo/CMO_0002341 white blood cell measurement http://purl.obolibrary.org/obo/CMO_0000036 blood cell measurement http://purl.obolibrary.org/obo/CMO_0000496 blood potassium level http://purl.obolibrary.org/obo/CMO_0000063 blood electrolyte measurement http://purl.obolibrary.org/obo/CMO_0000502 blood calcium level http://purl.obolibrary.org/obo/CMO_0000063 blood electrolyte measurement http://purl.obolibrary.org/obo/CMO_0002242 blood creatine kinase activity level http://purl.obolibrary.org/obo/CMO_0000064 blood enzyme activity level http://purl.obolibrary.org/obo/CMO_0000114 ventilation measurement http://purl.obolibrary.org/obo/CMO_0000094 respiratory system measurement http://purl.obolibrary.org/obo/CMO_0000289 respiration rate http://purl.obolibrary.org/obo/CMO_0000114 ventilation measurement http://purl.obolibrary.org/obo/CMO_0000183 head circumference http://purl.obolibrary.org/obo/CMO_0000182 head morphological measurement http://purl.obolibrary.org/obo/CMO_0000242 waist circumference http://purl.obolibrary.org/obo/CMO_0000296 abdominal morphological measurement http://purl.obolibrary.org/obo/CMO_0000002 heart rate http://purl.obolibrary.org/obo/CMO_0000670 heart measurement http://purl.obolibrary.org/obo/CMO_0000029 platelet count http://purl.obolibrary.org/obo/CMO_0000921 platelet measurement http://purl.obolibrary.org/obo/CMO_0001970 central nervous system measurement http://purl.obolibrary.org/obo/CMO_0001232 nervous system measurement http://purl.obolibrary.org/obo/CMO_0001241 cerebrospinal fluid chemistry measurement http://purl.obolibrary.org/obo/CMO_0001240 cerebrospinal fluid measurement http://purl.obolibrary.org/obo/CMO_0001242 cerebrospinal fluid electrolyte measurement http://purl.obolibrary.org/obo/CMO_0001241 cerebrospinal fluid chemistry measurement http://purl.obolibrary.org/obo/CMO_0001243 cerebrospinal fluid chloride level http://purl.obolibrary.org/obo/CMO_0001242 cerebrospinal fluid electrolyte measurement http://purl.obolibrary.org/obo/CMO_0001244 cerebrospinal fluid sodium level http://purl.obolibrary.org/obo/CMO_0001242 cerebrospinal fluid electrolyte measurement http://purl.obolibrary.org/obo/CMO_0000037 hematocrit http://purl.obolibrary.org/obo/CMO_0001356 red blood cell measurement http://purl.obolibrary.org/obo/CMO_0000038 mean corpuscular volume http://purl.obolibrary.org/obo/CMO_0001356 red blood cell measurement http://purl.obolibrary.org/obo/CMO_0001240 cerebrospinal fluid measurement http://purl.obolibrary.org/obo/CMO_0001970 central nervous system measurement http://purl.obolibrary.org/obo/CMO_0000027 white blood cell count http://purl.obolibrary.org/obo/CMO_0002341 white blood cell measurement http://purl.obolibrary.org/obo/CMO_0000064 blood enzyme activity level http://purl.obolibrary.org/obo/CMO_0002498 blood enzyme measurement http://purl.obolibrary.org/obo/MFOMD_0000024 pathological mental process http://purl.obolibrary.org/obo/OGMS_0000061 pathological bodily process http://purl.obolibrary.org/obo/OMIT_0028139 Prodromal Symptoms http://purl.obolibrary.org/obo/SYMP_0000462 symptom http://purl.obolibrary.org/obo/SYMP_0000410 neurological and physiological symptom http://purl.obolibrary.org/obo/SYMP_0000462 symptom http://purl.obolibrary.org/obo/SYMP_0000459 digestive system symptom http://purl.obolibrary.org/obo/SYMP_0000462 symptom http://purl.obolibrary.org/obo/SYMP_0000461 abdominal symptom http://purl.obolibrary.org/obo/SYMP_0000462 symptom http://purl.obolibrary.org/obo/SYMP_0000473 nutrition, metabolism, and development symptom http://purl.obolibrary.org/obo/SYMP_0000462 symptom http://purl.obolibrary.org/obo/SYMP_0000480 nervous system symptom http://purl.obolibrary.org/obo/SYMP_0000462 symptom http://purl.obolibrary.org/obo/SYMP_0000486 urinary system symptom http://purl.obolibrary.org/obo/SYMP_0000462 symptom http://purl.obolibrary.org/obo/SYMP_0000488 skin and integumentary tissue symptom http://purl.obolibrary.org/obo/SYMP_0000462 symptom http://purl.obolibrary.org/obo/SYMP_0000514 respiratory system and chest symptom http://purl.obolibrary.org/obo/SYMP_0000462 symptom http://purl.obolibrary.org/obo/SYMP_0000528 cardiovascular system symptom http://purl.obolibrary.org/obo/SYMP_0000462 symptom http://purl.obolibrary.org/obo/SYMP_0000567 general symptom http://purl.obolibrary.org/obo/SYMP_0000462 symptom http://purl.obolibrary.org/obo/SYMP_0000597 head and neck symptom http://purl.obolibrary.org/obo/SYMP_0000462 symptom http://purl.obolibrary.org/obo/SYMP_0000891 musculoskeletal system symptom http://purl.obolibrary.org/obo/SYMP_0000462 symptom http://purl.obolibrary.org/obo/RS_0001872 F344-Adms/Kyo http://purl.obolibrary.org/obo/RS_0000461 mutant strain http://purl.obolibrary.org/obo/RS_0001877 F344-Scn1am1Kyo http://purl.obolibrary.org/obo/RS_0000461 mutant strain http://purl.obolibrary.org/obo/RS_0003717 F344-Lgi1m1Kyo http://purl.obolibrary.org/obo/RS_0000461 mutant strain http://purl.obolibrary.org/obo/RS_0004561 SD-GEPR-3 http://purl.obolibrary.org/obo/RS_0000765 inbred strain http://purl.obolibrary.org/obo/RS_0000274 GEPR http://purl.obolibrary.org/obo/RS_0000765 inbred strain http://purl.obolibrary.org/obo/RS_0000480 GAERS http://purl.obolibrary.org/obo/RS_0000765 inbred strain http://purl.obolibrary.org/obo/RS_0000637 P77PMC http://purl.obolibrary.org/obo/RS_0000765 inbred strain http://purl.obolibrary.org/obo/RS_0000969 WAG/Rij http://purl.obolibrary.org/obo/RS_0000765 inbred strain http://purl.obolibrary.org/obo/RS_0001318 GRY/Idr http://purl.obolibrary.org/obo/RS_0000765 inbred strain http://purl.obolibrary.org/obo/RS_0004742 W/Lnne http://purl.obolibrary.org/obo/RS_0000765 inbred strain http://purl.obolibrary.org/obo/RS_0004315 SD-GEPR-9 http://purl.obolibrary.org/obo/RS_0000765 inbred strain http://purl.obolibrary.org/obo/NCIT_C63479 Gene Expression Analysis http://purl.obolibrary.org/obo/NCIT_C19770 Molecular Analysis https://bio.scai.fraunhofer.de/ontology/0000515 automotor seizure http://purl.obolibrary.org/obo/HP_0020219 Motor seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#convulsive_status_epilepticus convulsive status epilepticus http://purl.obolibrary.org/obo/HP_0032658 Status epilepticus with prominent motor symptoms https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_non_convulsive_status_epilepticus focal non convulsive status epilepticus http://purl.obolibrary.org/obo/HP_0032671 Non-convulsive status epilepticus without coma https://bio.scai.fraunhofer.de/ontology/epilepsy#generalized_non_convulsive_status_epilepticus_without_coma generalized non convulsive status epilepticus without coma http://purl.obolibrary.org/obo/HP_0032671 Non-convulsive status epilepticus without coma http://purl.obolibrary.org/obo/OMIT_0005690 Eating http://purl.obolibrary.org/obo/GO_0007610 behavior http://purl.obolibrary.org/obo/OMIT_0007063 Gestures http://purl.obolibrary.org/obo/GO_0007610 behavior http://purl.obolibrary.org/obo/OMIT_0007957 Hunger http://purl.obolibrary.org/obo/GO_0007610 behavior http://purl.obolibrary.org/obo/OMIT_0008942 Laughter http://purl.obolibrary.org/obo/GO_0007610 behavior http://purl.obolibrary.org/obo/OMIT_0012985 Rejection (Psychology) http://purl.obolibrary.org/obo/GO_0007610 behavior https://bio.scai.fraunhofer.de/ontology/epilepsy#moan moan http://purl.obolibrary.org/obo/GO_0007610 behavior https://bio.scai.fraunhofer.de/ontology/epilepsy#primitive_behavior primitive behavior http://purl.obolibrary.org/obo/GO_0007610 behavior https://bio.scai.fraunhofer.de/ontology/epilepsy#rubbing rubbing http://purl.obolibrary.org/obo/GO_0007610 behavior https://bio.scai.fraunhofer.de/ontology/epilepsy#screeching screeching http://purl.obolibrary.org/obo/GO_0007610 behavior http://purl.obolibrary.org/obo/HP_0100755 Abnormality of salivation http://purl.obolibrary.org/obo/HP_0031815 Abnormal oral physiology https://bio.scai.fraunhofer.de/ontology/epilepsy#cognitive_aura cognitive aura https://bio.scai.fraunhofer.de/ontology/mental_disorder#cognitive_symptom cognitive symptom https://bio.scai.fraunhofer.de/ontology/0000501 functional connectivity https://bio.scai.fraunhofer.de/ontology/0000500 connectivity https://bio.scai.fraunhofer.de/ontology/0000503 brain connectivity https://bio.scai.fraunhofer.de/ontology/0000500 connectivity https://bio.scai.fraunhofer.de/ontology/0000502 brain functional connectivity https://bio.scai.fraunhofer.de/ontology/0000501 functional connectivity https://bio.scai.fraunhofer.de/ontology/0000506 epileptic seizure network https://bio.scai.fraunhofer.de/ontology/0000505 seizure network https://bio.scai.fraunhofer.de/ontology/0000510 brain functional connectivity measure https://bio.scai.fraunhofer.de/ontology/0000508 functional connectivity measure http://purl.obolibrary.org/obo/MONDO_0015650 epilepsy syndrome https://bio.scai.fraunhofer.de/ontology/epilepsy#International_League_Against_Epilepsy_classification International League Against Epilepsy classification https://bio.scai.fraunhofer.de/ontology/epilepsy#epilepsy_classification epilepsy classification https://bio.scai.fraunhofer.de/ontology/epilepsy#International_League_Against_Epilepsy_classification International League Against Epilepsy classification https://bio.scai.fraunhofer.de/ontology/epilepsy#epilepsy_imitator epilepsy imitator https://bio.scai.fraunhofer.de/ontology/epilepsy#International_League_Against_Epilepsy_classification International League Against Epilepsy classification https://bio.scai.fraunhofer.de/ontology/epilepsy#seizure_classification seizure classification https://bio.scai.fraunhofer.de/ontology/epilepsy#International_League_Against_Epilepsy_classification International League Against Epilepsy classification https://bio.scai.fraunhofer.de/ontology/epilepsy#C57BL/10Bg_mouse C57BL/10Bg sps/sps mouse https://bio.scai.fraunhofer.de/ontology/epilepsy#absence_seizure_model absence seizure model https://bio.scai.fraunhofer.de/ontology/epilepsy#ducky_mouse ducky mouse https://bio.scai.fraunhofer.de/ontology/epilepsy#absence_seizure_model absence seizure model https://bio.scai.fraunhofer.de/ontology/epilepsy#lethargic_mouse lethargic mouse https://bio.scai.fraunhofer.de/ontology/epilepsy#absence_seizure_model absence seizure model https://bio.scai.fraunhofer.de/ontology/epilepsy#tottering_mouse tottering mouse https://bio.scai.fraunhofer.de/ontology/epilepsy#absence_seizure_model absence seizure model https://bio.scai.fraunhofer.de/ontology/epilepsy#epileptiform_benign_variant epileptiform benign variant https://bio.scai.fraunhofer.de/ontology/epilepsy#benign_EEG_pattern benign EEG pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#rhythmic_benign_variant rhythmic benign variant https://bio.scai.fraunhofer.de/ontology/epilepsy#benign_EEG_pattern benign EEG pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate_model methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate model https://bio.scai.fraunhofer.de/ontology/epilepsy#beta-carboline_model beta-carboline model https://bio.scai.fraunhofer.de/ontology/epilepsy#temporo-parieto-occipital_junction temporo-parieto-occipital junction https://bio.scai.fraunhofer.de/ontology/epilepsy#brain_junction brain junction https://bio.scai.fraunhofer.de/ontology/epilepsy#autosomal-dominant_lateral_temporal_lobe_epilepsy_model autosomal-dominant lateral temporal lobe epilepsy model https://bio.scai.fraunhofer.de/ontology/epilepsy#chemical_mutagenesis_derived_model chemical mutagenesis derived model https://bio.scai.fraunhofer.de/ontology/epilepsy#episodic_ataxia_type-1_model episodic ataxia type-1 model https://bio.scai.fraunhofer.de/ontology/epilepsy#chemical_mutagenesis_derived_model chemical mutagenesis derived model https://bio.scai.fraunhofer.de/ontology/epilepsy#episodic_ataxia_type-2_model episodic ataxia type-2 model https://bio.scai.fraunhofer.de/ontology/epilepsy#chemical_mutagenesis_derived_model chemical mutagenesis derived model https://bio.scai.fraunhofer.de/ontology/epilepsy#febrile_seizure_model febrile seizure model https://bio.scai.fraunhofer.de/ontology/epilepsy#chemical_mutagenesis_derived_model chemical mutagenesis derived model https://bio.scai.fraunhofer.de/ontology/epilepsy#anterior_cingulate_epilepsy anterior cingulate epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#cingulate_epilepsy cingulate epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#posterior_cingulate_epilepsy posterior cingulate epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#cingulate_epilepsy cingulate epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#N-methyl-DL-aspartate_model N-methyl-DL-aspartate model https://bio.scai.fraunhofer.de/ontology/epilepsy#convulsant_drug_model convulsant drug model https://bio.scai.fraunhofer.de/ontology/epilepsy#allylglycine_model allylglycine model https://bio.scai.fraunhofer.de/ontology/epilepsy#convulsant_drug_model convulsant drug model https://bio.scai.fraunhofer.de/ontology/epilepsy#beta-carboline_model beta-carboline model https://bio.scai.fraunhofer.de/ontology/epilepsy#convulsant_drug_model convulsant drug model https://bio.scai.fraunhofer.de/ontology/epilepsy#bicuculline_model bicuculline model https://bio.scai.fraunhofer.de/ontology/epilepsy#convulsant_drug_model convulsant drug model https://bio.scai.fraunhofer.de/ontology/epilepsy#cobalt_model cobalt model https://bio.scai.fraunhofer.de/ontology/epilepsy#convulsant_drug_model convulsant drug model https://bio.scai.fraunhofer.de/ontology/epilepsy#flurothyl_model flurothyl model https://bio.scai.fraunhofer.de/ontology/epilepsy#convulsant_drug_model convulsant drug model https://bio.scai.fraunhofer.de/ontology/epilepsy#kainic_acid_model kainic acid model https://bio.scai.fraunhofer.de/ontology/epilepsy#convulsant_drug_model convulsant drug model https://bio.scai.fraunhofer.de/ontology/epilepsy#lithium-pilocarpine_model lithium-pilocarpine model https://bio.scai.fraunhofer.de/ontology/epilepsy#convulsant_drug_model convulsant drug model https://bio.scai.fraunhofer.de/ontology/epilepsy#methoxypyridoxine_model methoxypyridoxine model https://bio.scai.fraunhofer.de/ontology/epilepsy#convulsant_drug_model convulsant drug model https://bio.scai.fraunhofer.de/ontology/epilepsy#penicillin_model penicillin model https://bio.scai.fraunhofer.de/ontology/epilepsy#convulsant_drug_model convulsant drug model https://bio.scai.fraunhofer.de/ontology/epilepsy#pentylenetetrazol_model pentylenetetrazol model https://bio.scai.fraunhofer.de/ontology/epilepsy#convulsant_drug_model convulsant drug model https://bio.scai.fraunhofer.de/ontology/epilepsy#picrotoxin_model picrotoxin model https://bio.scai.fraunhofer.de/ontology/epilepsy#convulsant_drug_model convulsant drug model https://bio.scai.fraunhofer.de/ontology/epilepsy#pilocarpine_model pilocarpine model https://bio.scai.fraunhofer.de/ontology/epilepsy#convulsant_drug_model convulsant drug model https://bio.scai.fraunhofer.de/ontology/epilepsy#strychnine_model strychnine model https://bio.scai.fraunhofer.de/ontology/epilepsy#convulsant_drug_model convulsant drug model https://bio.scai.fraunhofer.de/ontology/epilepsy#tetanus_toxin_model tetanus toxin model https://bio.scai.fraunhofer.de/ontology/epilepsy#convulsant_drug_model convulsant drug model https://bio.scai.fraunhofer.de/ontology/epilepsy#zinc_model zinc model https://bio.scai.fraunhofer.de/ontology/epilepsy#convulsant_drug_model convulsant drug model https://bio.scai.fraunhofer.de/ontology/epilepsy#macro-scale_model macro-scale model https://bio.scai.fraunhofer.de/ontology/epilepsy#deterministic_model deterministic model https://bio.scai.fraunhofer.de/ontology/epilepsy#micro-scale_model micro-scale model https://bio.scai.fraunhofer.de/ontology/epilepsy#deterministic_model deterministic model https://bio.scai.fraunhofer.de/ontology/epilepsy#combined_generalized_and_focal_epilepsy combined generalized and focal epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#epilepsy_classification epilepsy classification https://bio.scai.fraunhofer.de/ontology/epilepsy#unknown_epilepsy unknown epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#epilepsy_classification epilepsy classification http://purl.obolibrary.org/obo/MONDO_0017657 rare paroxysmal movement disorder https://bio.scai.fraunhofer.de/ontology/epilepsy#epilepsy_imitator epilepsy imitator https://bio.scai.fraunhofer.de/ontology/epilepsy#migraine_associated_disorder migraine associated disorder https://bio.scai.fraunhofer.de/ontology/epilepsy#epilepsy_imitator epilepsy imitator https://bio.scai.fraunhofer.de/ontology/epilepsy#14Hz_and_6Hz_positive_spike 14Hz and 6Hz positive spike https://bio.scai.fraunhofer.de/ontology/epilepsy#epileptiform_benign_variant epileptiform benign variant https://bio.scai.fraunhofer.de/ontology/epilepsy#6Hz_phantom_spike_and_wave 6Hz phantom spike and wave https://bio.scai.fraunhofer.de/ontology/epilepsy#epileptiform_benign_variant epileptiform benign variant https://bio.scai.fraunhofer.de/ontology/epilepsy#breach_rhythm breach rhythm https://bio.scai.fraunhofer.de/ontology/epilepsy#epileptiform_benign_variant epileptiform benign variant https://bio.scai.fraunhofer.de/ontology/epilepsy#small_sharp_spike small sharp spike https://bio.scai.fraunhofer.de/ontology/epilepsy#epileptiform_benign_variant epileptiform benign variant https://bio.scai.fraunhofer.de/ontology/epilepsy#wicket_wave wicket wave https://bio.scai.fraunhofer.de/ontology/epilepsy#epileptiform_benign_variant epileptiform benign variant https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure_with_anomia focal cognitive seizure with anomia https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure focal cognitive seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure_with_auditory_agnosia focal cognitive seizure with auditory agnosia https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure focal cognitive seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure_with_conduction_dysphasia/aphasia focal cognitive seizure with conduction dysphasia/aphasia https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure focal cognitive seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure_with_de_javu_/_jamais_vu focal cognitive seizure with de javu / jamais vu https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure focal cognitive seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure_with_dissociation focal cognitive seizure with dissociation https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure focal cognitive seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure_with_dyscalculia/acalculia focal cognitive seizure with dyscalculia/acalculia https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure focal cognitive seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure_with_dysgraphia/agraphia focal cognitive seizure with dysgraphia/agraphia https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure focal cognitive seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure_with_dyslexia/alexia focal cognitive seizure with dyslexia/alexia https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure focal cognitive seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure_with_expressive_dysphasia/aphasia focal cognitive seizure with expressive dysphasia/aphasia https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure focal cognitive seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure_with_forced_thinking focal cognitive seizure with forced thinking https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure focal cognitive seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure_with_hallucination focal cognitive seizure with hallucination https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure focal cognitive seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure_with_illusion focal cognitive seizure with illusion https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure focal cognitive seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure_with_left-right_confusion focal cognitive seizure with left-right confusion https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure focal cognitive seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure_with_memory_impairment focal cognitive seizure with memory impairment https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure focal cognitive seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure_with_neglect focal cognitive seizure with neglect https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure focal cognitive seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure_with_receptive_dysphasia/aphasia focal cognitive seizure with receptive dysphasia/aphasia https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure focal cognitive seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_behaviour_arrest_seizure focal behaviour arrest seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_non-motor_onset_seizure focal non-motor onset seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_cognitive_seizure focal cognitive seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_non-motor_onset_seizure focal non-motor onset seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#autonomic_status_epilepsy autonomic status epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_non_convulsive_status_epilepticus focal non convulsive status epilepticus https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_non_convulsive_status_epilepticus_with_impairment_of_consciousness focal non convulsive status epilepticus with impairment of consciousness 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https://bio.scai.fraunhofer.de/ontology/epilepsy#frontopolar_cortex_seizure frontopolar cortex seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#frontal_lobe_seizure frontal lobe seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#orbitofrontal_cortex_seizure orbitofrontal cortex seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#frontal_lobe_seizure frontal lobe seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#primary_sensorimotor_cortex_seizure primary sensorimotor cortex seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#frontal_lobe_seizure frontal lobe seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#supplementary_motor_area_seizure supplementary motor area seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#frontal_lobe_seizure frontal lobe seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#myoclonic_absence_status_epilepticus myoclonic absence status epilepticus https://bio.scai.fraunhofer.de/ontology/epilepsy#generalized_non_convulsive_status_epilepticus_without_coma generalized non convulsive status epilepticus without coma https://bio.scai.fraunhofer.de/ontology/epilepsy#complex_febrile_model complex febrile model https://bio.scai.fraunhofer.de/ontology/epilepsy#hyperthermic_seizure_model hyperthermic seizure model https://bio.scai.fraunhofer.de/ontology/epilepsy#hypoxic_and_ischemic_injury hypoxic and ischemic injury https://bio.scai.fraunhofer.de/ontology/epilepsy#hypoxic-ischemic hypoxic-ischemic https://bio.scai.fraunhofer.de/ontology/epilepsy#seizure_pattern seizure pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#ictal_pattern ictal pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#status_pattern status pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#ictal_pattern ictal pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#status_semiology status semiology 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human immunodeficiency virus infection https://bio.scai.fraunhofer.de/ontology/epilepsy#infectious_cause_of_seizure infectious cause of seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#invasive_subdural_grid_monitoring invasive subdural grid monitoring https://bio.scai.fraunhofer.de/ontology/epilepsy#invasive_preoperative_exploration invasive preoperative exploration https://bio.scai.fraunhofer.de/ontology/epilepsy#frontopolar_epilepsy frontopolar epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#lateral_frontal_epilepsy lateral frontal epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#prefrontal_epilepsy prefrontal epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#lateral_frontal_epilepsy lateral frontal epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#premotor_epilepsy premotor epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#lateral_frontal_epilepsy lateral frontal epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#occipital_pole_epilepsy occipital pole epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#lateral_occipital_epilepsy lateral occipital epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#mesial_temporal_lobe_epilepsy_by_specific_etiology mesial temporal lobe epilepsy by specific etiology https://bio.scai.fraunhofer.de/ontology/epilepsy#limbic_epilepsy limbic epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#biotinidase_and_holocarboxylase_synthase_deficiency biotinidase and holocarboxylase synthase deficiency https://bio.scai.fraunhofer.de/ontology/epilepsy#metabolic_etiology metabolic etiology http://purl.obolibrary.org/obo/MONDO_0044970 mitochondrial disease https://bio.scai.fraunhofer.de/ontology/epilepsy#metabolic_etiology metabolic etiology http://purl.obolibrary.org/obo/MONDO_0000188 GLUT1 deficiency syndrome https://bio.scai.fraunhofer.de/ontology/epilepsy#metabolic_etiology metabolic etiology https://bio.scai.fraunhofer.de/ontology/epilepsy#benign_paroxysmal_vertigo benign paroxysmal vertigo https://bio.scai.fraunhofer.de/ontology/epilepsy#migraine_associated_disorder migraine associated disorder https://bio.scai.fraunhofer.de/ontology/epilepsy#hypoxia_model hypoxia model https://bio.scai.fraunhofer.de/ontology/epilepsy#neonatal_hypoxia_model neonatal hypoxia model https://bio.scai.fraunhofer.de/ontology/epilepsy#autoregressive_model autoregressive model https://bio.scai.fraunhofer.de/ontology/epilepsy#non-deterministic_model non-deterministic model https://bio.scai.fraunhofer.de/ontology/epilepsy#generalized_linear_model generalized linear model https://bio.scai.fraunhofer.de/ontology/epilepsy#non-deterministic_model non-deterministic model https://bio.scai.fraunhofer.de/ontology/epilepsy#structural_equation_model structural equation model https://bio.scai.fraunhofer.de/ontology/epilepsy#non-deterministic_model non-deterministic model https://bio.scai.fraunhofer.de/ontology/epilepsy#non-invasive_epileptic_focus_localization non-invasive epileptic focus localization https://bio.scai.fraunhofer.de/ontology/epilepsy#non-invasive_preoperative_evaluation non-invasive preoperative evaluation https://bio.scai.fraunhofer.de/ontology/epilepsy#non-invasive_multichannel_magnetoencephalography non-invasive multichannel magnetoencephalography https://bio.scai.fraunhofer.de/ontology/epilepsy#non-invasive_preoperative_evaluation non-invasive preoperative evaluation https://bio.scai.fraunhofer.de/ontology/epilepsy#stereotactic_radiotherapy stereotactic radiotherapy https://bio.scai.fraunhofer.de/ontology/epilepsy#non-invasive_preoperative_evaluation non-invasive preoperative evaluation https://bio.scai.fraunhofer.de/ontology/epilepsy#K_complex K complex https://bio.scai.fraunhofer.de/ontology/epilepsy#normal_EEG_pattern normal EEG pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#V_wave V wave https://bio.scai.fraunhofer.de/ontology/epilepsy#normal_EEG_pattern normal EEG pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#alpha_rhythm alpha rhythm https://bio.scai.fraunhofer.de/ontology/epilepsy#normal_EEG_pattern normal EEG pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#beta_activity beta activity https://bio.scai.fraunhofer.de/ontology/epilepsy#normal_EEG_pattern normal EEG pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#delta_rhythm delta rhythm https://bio.scai.fraunhofer.de/ontology/epilepsy#normal_EEG_pattern normal EEG pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#gamma_rhythm gamma rhythm https://bio.scai.fraunhofer.de/ontology/epilepsy#normal_EEG_pattern normal EEG pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#lambda_wave lambda wave https://bio.scai.fraunhofer.de/ontology/epilepsy#normal_EEG_pattern normal EEG pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#mu_rhythm mu rhythm https://bio.scai.fraunhofer.de/ontology/epilepsy#normal_EEG_pattern normal EEG pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#positive_occipital_sharp_transients_of_sleep positive occipital sharp transients of sleep https://bio.scai.fraunhofer.de/ontology/epilepsy#normal_EEG_pattern normal EEG pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#sleep_spindle sleep spindle https://bio.scai.fraunhofer.de/ontology/epilepsy#normal_EEG_pattern normal EEG pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#theta_activity theta activity https://bio.scai.fraunhofer.de/ontology/epilepsy#normal_EEG_pattern normal EEG pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#lateral_occipital_epilepsy lateral occipital epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#occipital_lobe_epilepsy occipital lobe epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#mesial_occipital_epilepsy mesial occipital epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#occipital_lobe_epilepsy occipital lobe epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#extra_striate_cortex_seizure extra striate cortex seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#occipital_lobe_seizure occipital lobe seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#parieto-occipital_junction_seizure parieto-occipital junction seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#parietal_lobe_seizure parietal lobe seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#primary_visual_cortex_seizure primary visual cortex seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#occipital_lobe_seizure occipital lobe seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#seizure_arising_inferior_to_the_calcarine_fissure seizure arising inferior to the calcarine fissure https://bio.scai.fraunhofer.de/ontology/epilepsy#occipital_lobe_seizure occipital lobe seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#seizure_arising_superior_to_the_calcarine_fissure seizure arising superior to the calcarine fissure https://bio.scai.fraunhofer.de/ontology/epilepsy#occipital_lobe_seizure occipital lobe seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#horizontal_occular_oscillation horizontal occular oscillation https://bio.scai.fraunhofer.de/ontology/epilepsy#occular_oscillation occular oscillation https://bio.scai.fraunhofer.de/ontology/epilepsy#vertical_occular_oscillation vertical occular oscillation https://bio.scai.fraunhofer.de/ontology/epilepsy#occular_oscillation occular oscillation https://bio.scai.fraunhofer.de/ontology/epilepsy#lateral_parietal_epilepsy lateral parietal epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#parietal_lobe_epilepsy parietal lobe epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#mesial_parietal_epilepsy mesial parietal epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#parietal_lobe_epilepsy parietal lobe epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#dominant_parieto-temporal_region_seizure dominant parieto-temporal region seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#parietal_lobe_seizure parietal lobe seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#non_dominant_parietal_cortex_seizure non dominant parietal cortex seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#parietal_lobe_seizure parietal lobe seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#paracentral_lobule_seizure paracentral lobule seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#parietal_lobe_seizure parietal lobe seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#primary_sensory_area_(post-central_gyrus)_seizure primary sensory area (post-central gyrus) seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#parietal_lobe_seizure parietal lobe seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#secondary_sensory_area_(parietal_upper_bank_of_the_sylvian_fissure)_seizure secondary sensory area (parietal upper bank of the sylvian fissure) seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#parietal_lobe_seizure parietal lobe seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#sz_mutant_hamster sz mutant hamster https://bio.scai.fraunhofer.de/ontology/epilepsy#paroxysmal_dystonia_model paroxysmal dystonia model https://bio.scai.fraunhofer.de/ontology/epilepsy#amygdala_kindling amygdala kindling https://bio.scai.fraunhofer.de/ontology/epilepsy#pharmacoresistant_epilepsy_model pharmacoresistant epilepsy model https://bio.scai.fraunhofer.de/ontology/epilepsy#lamotrigine_resistant_kindled_model lamotrigine resistant kindled model https://bio.scai.fraunhofer.de/ontology/epilepsy#pharmacoresistant_epilepsy_model pharmacoresistant epilepsy model https://bio.scai.fraunhofer.de/ontology/epilepsy#flash flash https://bio.scai.fraunhofer.de/ontology/epilepsy#positive_visual_hallucination positive visual hallucination https://bio.scai.fraunhofer.de/ontology/epilepsy#flickering_light flickering light https://bio.scai.fraunhofer.de/ontology/epilepsy#positive_visual_hallucination positive visual hallucination https://bio.scai.fraunhofer.de/ontology/epilepsy#simple_visual_pattern simple visual pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#positive_visual_hallucination positive visual hallucination https://bio.scai.fraunhofer.de/ontology/epilepsy#spark spark https://bio.scai.fraunhofer.de/ontology/epilepsy#positive_visual_hallucination positive visual hallucination https://bio.scai.fraunhofer.de/ontology/epilepsy#fluid_percussion_injury_model fluid percussion injury model https://bio.scai.fraunhofer.de/ontology/epilepsy#posttraumatic_epilepsy_model posttraumatic epilepsy model https://bio.scai.fraunhofer.de/ontology/epilepsy#Subclinical_Rhythmical_Discharges_of_Adults subclinical rhythmical discharge of adults https://bio.scai.fraunhofer.de/ontology/epilepsy#rhythmic_benign_variant rhythmic benign variant https://bio.scai.fraunhofer.de/ontology/epilepsy#alpha_variant alpha variant https://bio.scai.fraunhofer.de/ontology/epilepsy#rhythmic_benign_variant rhythmic benign variant https://bio.scai.fraunhofer.de/ontology/epilepsy#frontal_arousal_rhythm frontal arousal rhythm https://bio.scai.fraunhofer.de/ontology/epilepsy#rhythmic_benign_variant rhythmic benign variant https://bio.scai.fraunhofer.de/ontology/epilepsy#midline_theta_rhythm midline theta rhythm https://bio.scai.fraunhofer.de/ontology/epilepsy#rhythmic_benign_variant rhythmic benign variant https://bio.scai.fraunhofer.de/ontology/epilepsy#rhythmic_temporal_theta_of_drowsiness rhythmic temporal theta of drowsiness https://bio.scai.fraunhofer.de/ontology/epilepsy#rhythmic_benign_variant rhythmic benign variant https://bio.scai.fraunhofer.de/ontology/epilepsy#frontal_lobe_seizure frontal lobe seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#seizure_based_on_lobar_localization seizure based on lobar localization https://bio.scai.fraunhofer.de/ontology/epilepsy#occipital_lobe_seizure occipital lobe seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#seizure_based_on_lobar_localization seizure based on lobar localization https://bio.scai.fraunhofer.de/ontology/epilepsy#parietal_lobe_seizure parietal lobe seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#seizure_based_on_lobar_localization seizure based on lobar localization https://bio.scai.fraunhofer.de/ontology/epilepsy#temporal_lobe_seizure temporal lobe seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#seizure_based_on_lobar_localization seizure based on lobar localization https://bio.scai.fraunhofer.de/ontology/epilepsy#unknown_onset_seizure unknown onset seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#seizure_classification seizure classification https://bio.scai.fraunhofer.de/ontology/epilepsy#immediate_and_early_post_traumatic_seizure immediate and early post traumatic seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#seizure_not_necessarily_requiring_a_diagnosis_of_epilepsy seizure not necessarily requiring a diagnosis of epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#rarely_repeated_seizure_(oligo-epilepsy) rarely repeated seizure (oligo-epilepsy) https://bio.scai.fraunhofer.de/ontology/epilepsy#seizure_not_necessarily_requiring_a_diagnosis_of_epilepsy seizure not necessarily requiring a diagnosis of epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#childhood_epilepsy_with_occipital_paroxysm childhood epilepsy with occipital paroxysm https://bio.scai.fraunhofer.de/ontology/epilepsy#simple_focal_seizure simple focal seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#cingulate_epilepsy cingulate epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#simple_focal_seizure simple focal seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#hypothalamic_epilepsy hypothalamic epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#simple_focal_seizure simple focal seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#insular_epilepsy insular epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#simple_focal_seizure simple focal seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#parietal_lobe_epilepsy parietal lobe epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#simple_focal_seizure simple focal seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#alpha_coma alpha coma https://bio.scai.fraunhofer.de/ontology/epilepsy#special_pattern special pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#asymmetry_pattern asymmetry pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#special_pattern special pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#background_suppression background suppression https://bio.scai.fraunhofer.de/ontology/epilepsy#special_pattern special pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#beta_coma beta coma https://bio.scai.fraunhofer.de/ontology/epilepsy#special_pattern special pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#delta_coma delta coma https://bio.scai.fraunhofer.de/ontology/epilepsy#special_pattern special pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#electrocerebral_inactivity electrocerebral inactivity https://bio.scai.fraunhofer.de/ontology/epilepsy#special_pattern special pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#excessive_fast_pattern excessive fast pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#special_pattern special pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#periodic_pattern periodic pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#special_pattern special pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#sleep_onset_rapid_eye_movement sleep onset rapid eye movement https://bio.scai.fraunhofer.de/ontology/epilepsy#special_pattern special pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#spindle_stupor spindle stupor https://bio.scai.fraunhofer.de/ontology/epilepsy#special_pattern special pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#theta_coma theta coma https://bio.scai.fraunhofer.de/ontology/epilepsy#special_pattern special pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#triphasic_wave triphasic wave https://bio.scai.fraunhofer.de/ontology/epilepsy#special_pattern special pattern http://purl.obolibrary.org/obo/NBO_0000159 rapid eye movement sleep https://bio.scai.fraunhofer.de/ontology/epilepsy#special_pattern special pattern https://bio.scai.fraunhofer.de/ontology/epilepsy#amnestic_seizure amnestic seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#special_seizure special seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#hypnogogic_seizure hypnogogic seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#special_seizure special seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#hypnopompic_seizure hypnopompic seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#special_seizure special seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#hippocampal_sclerosis hippocampal sclerosis https://bio.scai.fraunhofer.de/ontology/epilepsy#structural_etiology structural etiology https://bio.scai.fraunhofer.de/ontology/epilepsy#hypoxic-ischemic hypoxic-ischemic https://bio.scai.fraunhofer.de/ontology/epilepsy#structural_etiology structural etiology https://bio.scai.fraunhofer.de/ontology/epilepsy#limbic_epilepsy limbic epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#symptomatic_epilepsy symptomatic epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#neocortical_epilepsy neocortical epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#symptomatic_epilepsy symptomatic epilepsy https://bio.scai.fraunhofer.de/ontology/epilepsy#lateral_/_neocortical_temporal_lobe_seizure lateral / neocortical temporal lobe seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#temporal_lobe_seizure temporal lobe seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#mesial_temporal_lobe_seizure_including_hippocampus mesial temporal lobe seizure including hippocampus https://bio.scai.fraunhofer.de/ontology/epilepsy#temporal_lobe_seizure temporal lobe seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#3-nitropropionic_acid-induced_seizure 3-nitropropionic acid-induced seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#toxic_cause_of_seizure toxic cause of seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#4-aminopyridine-induced_seizure 4-aminopyridine-induced seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#toxic_cause_of_seizure toxic cause of seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#channel_blocker-induced_seizure channel blocker-induced seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#toxic_cause_of_seizure toxic cause of seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#kainic_acid-induced_seizure kainic acid-induced seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#toxic_cause_of_seizure toxic cause of seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#metaldehyde-induced_seizure metaldehyde-induced seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#toxic_cause_of_seizure toxic cause of seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#phenytion-induced_seizure phenytion-induced seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#toxic_cause_of_seizure toxic cause of seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#picrotoxin-induced_seizure picrotoxin-induced seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#toxic_cause_of_seizure toxic cause of seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#seizure_induced_by_chlorinated_hydrocarbon seizure induced by chlorinated hydrocarbon https://bio.scai.fraunhofer.de/ontology/epilepsy#toxic_cause_of_seizure toxic cause of seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#sharp_wave sharp wave https://bio.scai.fraunhofer.de/ontology/epilepsy#transient transient https://bio.scai.fraunhofer.de/ontology/epilepsy#unclassified_seizure_onset unclassified seizure onset https://bio.scai.fraunhofer.de/ontology/epilepsy#unknown_onset_seizure unknown onset seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#right_fronto_parietal_abscess right fronto parietal abscess http://purl.obolibrary.org/obo/HP_0030049 Brain abscess http://purl.obolibrary.org/obo/NBO_0000231 excitement behavior http://purl.obolibrary.org/obo/NBO_0000003 emotional behavior http://purl.obolibrary.org/obo/NBO_0000747 jaw movement http://purl.obolibrary.org/obo/NBO_0000007 mouth movement http://purl.obolibrary.org/obo/NBO_0000473 rhythmic behavior phenotype http://purl.obolibrary.org/obo/NBO_0000243 behavioral phenotype http://purl.obolibrary.org/obo/NBO_0000002 whole body movement http://purl.obolibrary.org/obo/NBO_0000338 kinesthetic behavior https://bio.scai.fraunhofer.de/ontology/epilepsy#rapid_eye_movement_atonia rapid eye movement atonia http://purl.obolibrary.org/obo/NBO_0000419 sleeping behavior phenotype https://bio.scai.fraunhofer.de/ontology/epilepsy#complex_visual_hallucination complex visual hallucination http://purl.obolibrary.org/obo/NBO_0000609 visual hallucination https://bio.scai.fraunhofer.de/ontology/epilepsy#dreamy_state dreamy state http://purl.obolibrary.org/obo/NBO_0000609 visual hallucination https://bio.scai.fraunhofer.de/ontology/epilepsy#heautoscopy heautoscopy http://purl.obolibrary.org/obo/NBO_0000609 visual hallucination https://bio.scai.fraunhofer.de/ontology/epilepsy#person_hallucination person hallucination http://purl.obolibrary.org/obo/NBO_0000609 visual hallucination https://bio.scai.fraunhofer.de/ontology/epilepsy#positive_visual_hallucination positive visual hallucination http://purl.obolibrary.org/obo/NBO_0000609 visual hallucination https://bio.scai.fraunhofer.de/ontology/epilepsy#scenery_hallucination scenery hallucination http://purl.obolibrary.org/obo/NBO_0000609 visual hallucination https://bio.scai.fraunhofer.de/ontology/epilepsy#simple_visual_hallucination simple visual hallucination http://purl.obolibrary.org/obo/NBO_0000609 visual hallucination https://bio.scai.fraunhofer.de/ontology/epilepsy#music_hallucination music hallucination http://purl.obolibrary.org/obo/NBO_0000610 auditory hallucination https://bio.scai.fraunhofer.de/ontology/epilepsy#music_tone music tone http://purl.obolibrary.org/obo/NBO_0000610 auditory hallucination https://bio.scai.fraunhofer.de/ontology/epilepsy#rushing_noise rushing noise http://purl.obolibrary.org/obo/NBO_0000610 auditory hallucination https://bio.scai.fraunhofer.de/ontology/epilepsy#urine_organic_acid_test urine organic acid test http://purl.obolibrary.org/obo/MMO_0000147 urine analysis http://purl.obolibrary.org/obo/HP_0025615 Abscess http://purl.obolibrary.org/obo/HP_0032251 Abnormal immune system morphology http://purl.obolibrary.org/obo/OMIT_0011757 Photic Stimulation http://purl.obolibrary.org/obo/ERO_0000007 technique https://bio.scai.fraunhofer.de/ontology/epilepsy#1.5_Tesla_magnetic_resonance_imaging 1.5 Tesla magnetic resonance imaging http://purl.obolibrary.org/obo/ERO_0001235 magnetic resonance imaging https://bio.scai.fraunhofer.de/ontology/epilepsy#gene_panel_sequencing gene panel sequencing http://purl.obolibrary.org/obo/ERO_0001286 nucleic acid assay http://purl.obolibrary.org/obo/OMIT_0027688 Neuroimaging http://purl.obolibrary.org/obo/ERO_0001312 imaging technique https://bio.scai.fraunhofer.de/ontology/epilepsy#Wada_test Wada test http://purl.obolibrary.org/obo/ERO_0001330 neuropsychological testing https://bio.scai.fraunhofer.de/ontology/epilepsy#language_functional_magnetic_resonance_imaging language functional magnetic resonance imaging http://purl.obolibrary.org/obo/ERO_0002178 functional magnetic resonance imaging https://bio.scai.fraunhofer.de/ontology/epilepsy#after_discharge afterdischarges model http://purl.obolibrary.org/obo/NCIT_C19021 Rodent Model of Disease https://bio.scai.fraunhofer.de/ontology/epilepsy#chronic_spontaneous_limbic_seizure_model chronic spontaneous limbic seizure model http://purl.obolibrary.org/obo/NCIT_C19021 Rodent Model of Disease https://bio.scai.fraunhofer.de/ontology/epilepsy#convulsant_drug_model convulsant drug model http://purl.obolibrary.org/obo/NCIT_C19021 Rodent Model of Disease https://bio.scai.fraunhofer.de/ontology/epilepsy#electroshock_stimulation_model electroshock stimulation model http://purl.obolibrary.org/obo/NCIT_C19021 Rodent Model of Disease https://bio.scai.fraunhofer.de/ontology/epilepsy#hyperthermic_seizure_model hyperthermic seizure model http://purl.obolibrary.org/obo/NCIT_C19021 Rodent Model of Disease https://bio.scai.fraunhofer.de/ontology/epilepsy#neonatal_hypoxia_model neonatal hypoxia model http://purl.obolibrary.org/obo/NCIT_C19021 Rodent Model of Disease https://bio.scai.fraunhofer.de/ontology/epilepsy#organophosphates_model organophosphates model http://purl.obolibrary.org/obo/NCIT_C19021 Rodent Model of Disease https://bio.scai.fraunhofer.de/ontology/epilepsy#pharmacoresistant_epilepsy_model pharmacoresistant epilepsy model http://purl.obolibrary.org/obo/NCIT_C19021 Rodent Model of Disease https://bio.scai.fraunhofer.de/ontology/epilepsy#posttraumatic_epilepsy_model posttraumatic epilepsy model http://purl.obolibrary.org/obo/NCIT_C19021 Rodent Model of Disease https://bio.scai.fraunhofer.de/ontology/epilepsy#high_potassium_slice_model high potassium slice model http://purl.obolibrary.org/obo/NCIT_C19146 In Vitro Model https://bio.scai.fraunhofer.de/ontology/epilepsy#4-aminopyridine_slice_model 4-aminopyridine slice model http://purl.obolibrary.org/obo/NCIT_C19146 In Vitro Model https://bio.scai.fraunhofer.de/ontology/epilepsy#calcium-activated_potassium_channel_model calcium-activated potassium channel model http://purl.obolibrary.org/obo/NCIT_C19146 In Vitro Model https://bio.scai.fraunhofer.de/ontology/epilepsy#low_magnesium_slice_model low magnesium slice model http://purl.obolibrary.org/obo/NCIT_C19146 In Vitro Model https://bio.scai.fraunhofer.de/ontology/epilepsy#organotypic_slice_cultures organotypic slice cultures http://purl.obolibrary.org/obo/NCIT_C19146 In Vitro Model https://bio.scai.fraunhofer.de/ontology/epilepsy#El_mouse El mouse http://purl.obolibrary.org/obo/NCIT_C19272 Transgenic Model https://bio.scai.fraunhofer.de/ontology/epilepsy#absence_seizure_model absence seizure model http://purl.obolibrary.org/obo/NCIT_C19272 Transgenic Model https://bio.scai.fraunhofer.de/ontology/epilepsy#audiogenic_model audiogenic model http://purl.obolibrary.org/obo/NCIT_C19272 Transgenic Model https://bio.scai.fraunhofer.de/ontology/epilepsy#chemical_mutagenesis_derived_model chemical mutagenesis derived model http://purl.obolibrary.org/obo/NCIT_C19272 Transgenic Model https://bio.scai.fraunhofer.de/ontology/epilepsy#in_silico_model in silico model http://purl.obolibrary.org/obo/NCIT_C19272 Transgenic Model https://bio.scai.fraunhofer.de/ontology/epilepsy#paroxysmal_dystonia_model paroxysmal dystonia model http://purl.obolibrary.org/obo/NCIT_C19272 Transgenic Model https://bio.scai.fraunhofer.de/ontology/epilepsy#electrically_kindled_cat electrically kindled cat http://purl.obolibrary.org/obo/NCIT_C19300 Non-Rodent Model http://purl.obolibrary.org/obo/OMIT_0016978 Head Injuries, Closed http://purl.obolibrary.org/obo/NCIT_C34660 Head Injury https://bio.scai.fraunhofer.de/ontology/epilepsy#benign_myoclonus_of_infancy_and_shuddering_attack benign myoclonus of infancy and shuddering attack http://purl.obolibrary.org/obo/NCIT_C69023 Miscellaneous https://bio.scai.fraunhofer.de/ontology/epilepsy#jitteriness jitteriness http://purl.obolibrary.org/obo/NCIT_C69023 Miscellaneous https://bio.scai.fraunhofer.de/ontology/epilepsy#non-epileptic_head_drop non-epileptic head drop http://purl.obolibrary.org/obo/NCIT_C69023 Miscellaneous http://purl.obolibrary.org/obo/DOID_310 MERRF syndrome http://purl.obolibrary.org/obo/MONDO_0044970 mitochondrial disease http://purl.obolibrary.org/obo/OMIT_0008479 Intelligence Tests http://purl.obolibrary.org/obo/NCIT_C20993 Research or Clinical Assessment Tool https://bio.scai.fraunhofer.de/ontology/epilepsyZung_self-rating_anxiety_scale Zung self-rating anxiety scale http://purl.obolibrary.org/obo/NCIT_C20993 Research or Clinical Assessment Tool https://bio.scai.fraunhofer.de/ontology/epilepsy#ASQ_(age_and_sex_questionnaire) age and sex questionnaire http://purl.obolibrary.org/obo/NCIT_C20993 Research or Clinical Assessment Tool https://bio.scai.fraunhofer.de/ontology/epilepsy#International_League_Against_Epilepsy_classification International League Against Epilepsy classification http://purl.obolibrary.org/obo/NCIT_C20993 Research or Clinical Assessment Tool https://bio.scai.fraunhofer.de/ontology/epilepsy#World_Health_Organization_quality_of_life_instrument,_short_form World Health Organization quality of life instrument, short form http://purl.obolibrary.org/obo/NCIT_C20993 Research or Clinical Assessment Tool https://bio.scai.fraunhofer.de/ontology/epilepsy#mini-international_neuropsychiatric_interview mini-international neuropsychiatric interview http://purl.obolibrary.org/obo/NCIT_C20993 Research or Clinical Assessment Tool https://bio.scai.fraunhofer.de/ontology/epilepsy#neurological_disorders_depression_inventory_for_epilepsy neurological disorders depression inventory for epilepsy http://purl.obolibrary.org/obo/NCIT_C20993 Research or Clinical Assessment Tool https://bio.scai.fraunhofer.de/ontology/epilepsy#non-invasive_assessment_of_language_dominance non-invasive assessment of language dominance http://purl.obolibrary.org/obo/NCIT_C20993 Research or Clinical Assessment Tool https://bio.scai.fraunhofer.de/ontology/epilepsy#quality_of_life_in_epilepsy_inventory_-_31 quality of life in epilepsy inventory - 31 http://purl.obolibrary.org/obo/NCIT_C20993 Research or Clinical Assessment Tool https://bio.scai.fraunhofer.de/ontology/epilepsy#quality_of_life_in_epilepsy_inventory_-_89 quality of life in epilepsy inventory - 89 http://purl.obolibrary.org/obo/NCIT_C20993 Research or Clinical Assessment Tool https://bio.scai.fraunhofer.de/ontology/epilepsy#somatoform_dissociation_questionnaire somatoform dissociation questionnaire http://purl.obolibrary.org/obo/NCIT_C20993 Research or Clinical Assessment Tool http://purl.obolibrary.org/obo/NCIT_C157609 Complication due to Medical/Surgical Care http://purl.obolibrary.org/obo/NCIT_C2959 Complication http://purl.obolibrary.org/obo/OMIT_0005788 Eidetic Imagery http://purl.obolibrary.org/obo/NCIT_C35470 Behavioral Disorder https://bio.scai.fraunhofer.de/ontology/epilepsy#non-epileptic_seizure non-epileptic seizure http://purl.obolibrary.org/obo/NCIT_C35470 Behavioral Disorder https://bio.scai.fraunhofer.de/ontology/epilepsy#out_of_body_experience out of body experience http://purl.obolibrary.org/obo/NCIT_C35470 Behavioral Disorder https://bio.scai.fraunhofer.de/ontology/epilepsy#self_gratification self gratification http://purl.obolibrary.org/obo/NCIT_C35470 Behavioral Disorder https://bio.scai.fraunhofer.de/ontology/epilepsy#tantrum_and_rage_reaction tantrum and rage reaction http://purl.obolibrary.org/obo/NCIT_C35470 Behavioral Disorder http://purl.obolibrary.org/obo/OMIT_0002726 Aversive Therapy http://purl.obolibrary.org/obo/NCIT_C15308 Psychotherapy http://purl.obolibrary.org/obo/OMIT_0019406 Aromatherapy http://purl.obolibrary.org/obo/NCIT_C15308 Psychotherapy http://purl.obolibrary.org/obo/NCBITaxon_8355 Xenopus laevis http://purl.obolibrary.org/obo/NCBITaxon_8292 Amphibia http://purl.obolibrary.org/obo/NCBITaxon_100937 Papio papio http://purl.obolibrary.org/obo/NCBITaxon_9443 Primates http://purl.obolibrary.org/obo/NCBITaxon_9606 Homo sapiens http://purl.obolibrary.org/obo/NCBITaxon_9443 Primates http://purl.obolibrary.org/obo/NCBITaxon_9544 Macaca mulatta http://purl.obolibrary.org/obo/NCBITaxon_9443 Primates http://purl.obolibrary.org/obo/UBERON_0005913 zone of bone organ http://purl.obolibrary.org/obo/UBERON_0034944 zone of organ https://bio.scai.fraunhofer.de/ontology/epilepsy#artifact_obscured_EEG artifact obscured EEG http://purl.obolibrary.org/obo/HP_0025373 Interictal EEG abnormality https://bio.scai.fraunhofer.de/ontology/epilepsy#benign_focal_epileptiform_discharge_of_childhood benign focal epileptiform discharge of childhood http://purl.obolibrary.org/obo/HP_0025373 Interictal EEG abnormality https://bio.scai.fraunhofer.de/ontology/epilepsy#bilateral_periodic_lateralized_epileptiform_discharge bilateral periodic lateralized epileptiform discharge http://purl.obolibrary.org/obo/HP_0025373 Interictal EEG abnormality https://bio.scai.fraunhofer.de/ontology/epilepsy#dysmature dysmature http://purl.obolibrary.org/obo/HP_0025373 Interictal EEG abnormality https://bio.scai.fraunhofer.de/ontology/epilepsy#electrodecrement electrodecrement http://purl.obolibrary.org/obo/HP_0025373 Interictal EEG abnormality https://bio.scai.fraunhofer.de/ontology/epilepsy#sharp_and_slow_wave_complex sharp and slow wave complex http://purl.obolibrary.org/obo/HP_0025373 Interictal EEG abnormality https://bio.scai.fraunhofer.de/ontology/epilepsy#spike_and_slow_wave_complex spike and slow wave complex http://purl.obolibrary.org/obo/HP_0025373 Interictal EEG abnormality https://bio.scai.fraunhofer.de/ontology/0000504 seizure event http://purl.obolibrary.org/obo/NCIT_C25499 Event http://purl.obolibrary.org/obo/OMIT_0008800 Kindling model http://purl.obolibrary.org/obo/NCIT_C16866 Model https://bio.scai.fraunhofer.de/ontology/0000514 intracranial electrode http://purl.obolibrary.org/obo/NCIT_C49936 Electrode Device https://bio.scai.fraunhofer.de/ontology/0000516 multi-contact electrode http://purl.obolibrary.org/obo/NCIT_C49936 Electrode Device https://bio.scai.fraunhofer.de/ontology/epilepsy#genetic_etiology genetic etiology http://purl.obolibrary.org/obo/NCIT_C16390 Etiology https://bio.scai.fraunhofer.de/ontology/epilepsy#immune_etiology immune etiology http://purl.obolibrary.org/obo/NCIT_C16390 Etiology https://bio.scai.fraunhofer.de/ontology/epilepsy#infectious_etiology infectious etiology http://purl.obolibrary.org/obo/NCIT_C16390 Etiology https://bio.scai.fraunhofer.de/ontology/epilepsy#metabolic_etiology metabolic etiology http://purl.obolibrary.org/obo/NCIT_C16390 Etiology https://bio.scai.fraunhofer.de/ontology/epilepsy#structural_etiology structural etiology http://purl.obolibrary.org/obo/NCIT_C16390 Etiology https://bio.scai.fraunhofer.de/ontology/epilepsy#unknown_etiology unknown etiology http://purl.obolibrary.org/obo/NCIT_C16390 Etiology https://bio.scai.fraunhofer.de/ontology/0000505 seizure network http://purl.obolibrary.org/obo/NCIT_C17429 Neural Network https://bio.scai.fraunhofer.de/ontology/0000507 brain functional connectivity network http://purl.obolibrary.org/obo/NCIT_C17429 Neural Network http://purl.obolibrary.org/obo/NCIT_C19146 In Vitro Model http://purl.obolibrary.org/obo/NCIT_C17456 Experimental Model http://purl.obolibrary.org/obo/NCIT_C19148 In Vivo Model http://purl.obolibrary.org/obo/NCIT_C17456 Experimental Model http://purl.obolibrary.org/obo/NCIT_C17456 Experimental Model http://purl.obolibrary.org/obo/NCIT_C80519 Biological Model https://bio.scai.fraunhofer.de/ontology/epilepsy#invasive_preoperative_exploration invasive preoperative exploration http://purl.obolibrary.org/obo/NCIT_C139982 Pre-operative Evaluation https://bio.scai.fraunhofer.de/ontology/epilepsy#non-invasive_preoperative_evaluation non-invasive preoperative evaluation http://purl.obolibrary.org/obo/NCIT_C139982 Pre-operative Evaluation http://purl.obolibrary.org/obo/MONDO_0016685 low-grade astrocytoma http://purl.obolibrary.org/obo/MONDO_0021638 low grade astrocytic tumor https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_emotional_seizure_with_anger focal emotional seizure with anger http://purl.obolibrary.org/obo/HP_0025613 Focal emotional seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_emotional_seizure_with_fear/anxiety/panic focal emotional seizure with fear/anxiety/panic http://purl.obolibrary.org/obo/HP_0025613 Focal emotional seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#focal_emotional_seizure_with_pleasure focal emotional seizure with pleasure http://purl.obolibrary.org/obo/HP_0025613 Focal emotional seizure http://purl.obolibrary.org/obo/NBO_0000685 continuous seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#autoimmune_seizure autoimmune seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#early-onset_benign_childhood_occipital_seizure early-onset benign childhood occipital seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#electrographic_seizure electrographic seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#elementary_partial_seizure elementary partial seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#emetic_seizure emetic seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#experiential_sensory_seizures experiential sensory seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#gait_induced_seizure gait induced seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#hypehydrotic_seizure hypehydrotic seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#immediate_and_early_post_cerebral_insult_seizure immediate and early post cerebral insult seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#inhibitory_motor_seizure inhibitory motor seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#insular_lobe_seizure insular lobe seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#late-onset_benign_occipital_seizure late-onset benign occipital seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#late_post-traumatic_seizure late post-traumatic seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#negative_motor_seizure negative motor seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#seizure_not_necessarily_requiring_a_diagnosis_of_epilepsy seizure not necessarily requiring a diagnosis of epilepsy http://purl.obolibrary.org/obo/SYMP_0000124 seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#self_limited_seizure self limited seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#sexual_seizure sexual seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#sialorrheic_seizure sialorrheic seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#single_seizure_or_isolated_clusters_of_seizure single seizure or isolated clusters of seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#special_seizure special seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#vasomotor_seizure vasomotor seizure http://purl.obolibrary.org/obo/SYMP_0000124 seizure https://bio.scai.fraunhofer.de/ontology/epilepsy#vertigo_aura vertigo aura http://purl.obolibrary.org/obo/SYMP_0000124 seizure http://purl.obolibrary.org/obo/SYMP_0000396 mydriasis http://purl.obolibrary.org/obo/SYMP_0000254 dilated pupil http://purl.obolibrary.org/obo/SYMP_0000051 hydrocephalus http://purl.obolibrary.org/obo/SYMP_0000387 head symptom https://bio.scai.fraunhofer.de/ontology/epilepsy#speech_arrest speech arrest http://purl.obolibrary.org/obo/SYMP_0000387 head symptom https://bio.scai.fraunhofer.de/ontology/epilepsy#speech_interrupted speech interrupted http://purl.obolibrary.org/obo/SYMP_0000387 head symptom http://purl.obolibrary.org/obo/SYMP_0019163 eye symptom http://purl.obolibrary.org/obo/SYMP_0000387 head symptom http://purl.obolibrary.org/obo/SYMP_0000719 memory impairment http://purl.obolibrary.org/obo/SYMP_0000410 neurological and physiological symptom https://bio.scai.fraunhofer.de/ontology/epilepsy#auditory_illusion auditory illusion http://purl.obolibrary.org/obo/SYMP_0000410 neurological and physiological symptom https://bio.scai.fraunhofer.de/ontology/epilepsy#gustatory_illusion gustatory illusion http://purl.obolibrary.org/obo/SYMP_0000410 neurological and physiological symptom http://purl.obolibrary.org/obo/SYMP_0000254 dilated pupil http://purl.obolibrary.org/obo/SYMP_0000417 pupil symptom https://bio.scai.fraunhofer.de/ontology/epilepsy#borborygmi borborygmi http://purl.obolibrary.org/obo/SYMP_0000459 digestive system symptom http://purl.obolibrary.org/obo/SYMP_0000188 abdominal discomfort http://purl.obolibrary.org/obo/SYMP_0000461 abdominal symptom https://bio.scai.fraunhofer.de/ontology/mental_disorder#cognitive_symptom cognitive symptom http://purl.obolibrary.org/obo/SYMP_0000480 nervous system symptom https://bio.scai.fraunhofer.de/ontology/epilepsy#autonomic_imbalance autonomic imbalance http://purl.obolibrary.org/obo/SYMP_0000480 nervous system symptom https://bio.scai.fraunhofer.de/ontology/epilepsy#blank_stare blank stare http://purl.obolibrary.org/obo/SYMP_0000480 nervous system symptom http://purl.obolibrary.org/obo/SYMP_0000124 seizure http://purl.obolibrary.org/obo/SYMP_0000480 nervous system symptom http://purl.obolibrary.org/obo/SYMP_0000598 respiratory abnormality http://purl.obolibrary.org/obo/SYMP_0000514 respiratory system and chest symptom https://bio.scai.fraunhofer.de/ontology/epilepsy#diaphragmatic_breathing diaphragmatic breathing http://purl.obolibrary.org/obo/SYMP_0000514 respiratory system and chest symptom https://bio.scai.fraunhofer.de/ontology/epilepsy#ictal_or_post-ictal_respiratory_abnormality ictal or post-ictal respiratory abnormality http://purl.obolibrary.org/obo/SYMP_0000514 respiratory system and chest symptom https://bio.scai.fraunhofer.de/ontology/epilepsy#ictal_or_post-ictal_cardiac_abnormality ictal or post-ictal cardiac abnormality http://purl.obolibrary.org/obo/SYMP_0000528 cardiovascular system symptom http://purl.obolibrary.org/obo/SYMP_0000566 sleep disturbance http://purl.obolibrary.org/obo/SYMP_0000567 general symptom http://purl.obolibrary.org/obo/SYMP_0000387 head symptom http://purl.obolibrary.org/obo/SYMP_0000597 head and neck symptom https://bio.scai.fraunhofer.de/ontology/epilepsy#pedaling pedaling http://purl.obolibrary.org/obo/SYMP_0000891 musculoskeletal system symptom https://bio.scai.fraunhofer.de/ontology/epilepsy#tapping tapping http://purl.obolibrary.org/obo/SYMP_0000891 musculoskeletal system symptom http://purl.obolibrary.org/obo/SYMP_0000183 muscle symptom http://purl.obolibrary.org/obo/SYMP_0000891 musculoskeletal system symptom http://purl.obolibrary.org/obo/SYMP_0000417 pupil symptom http://purl.obolibrary.org/obo/SYMP_0019163 eye symptom http://purl.obolibrary.org/obo/NCIT_C65017 Nutritional Therapy http://purl.obolibrary.org/obo/OGMS_0000112 therapeutic procedure http://purl.obolibrary.org/obo/OMIT_0006603 First Aid http://purl.obolibrary.org/obo/OGMS_0000112 therapeutic procedure http://purl.obolibrary.org/obo/OMIT_0015836 Yoga http://purl.obolibrary.org/obo/OGMS_0000112 therapeutic procedure http://purl.obolibrary.org/obo/OMIT_0026330 Vagus Nerve Stimulation http://purl.obolibrary.org/obo/OGMS_0000112 therapeutic procedure https://bio.scai.fraunhofer.de/ontology/epilepsy#multiple_sleep_latency_test multiple sleep latency test http://purl.obolibrary.org/obo/OGMS_0000112 therapeutic procedure https://bio.scai.fraunhofer.de/ontology/epilepsy#non-surgical_stimulation non-surgical stimulation http://purl.obolibrary.org/obo/OGMS_0000112 therapeutic procedure https://bio.scai.fraunhofer.de/ontology/epilepsy#responsive_neurostimulation responsive neurostimulation http://purl.obolibrary.org/obo/OGMS_0000112 therapeutic procedure https://bio.scai.fraunhofer.de/ontology/epilepsy#trigeminal_nerve_stimulation trigeminal nerve stimulation http://purl.obolibrary.org/obo/OGMS_0000112 therapeutic procedure https://bio.scai.fraunhofer.de/ontology/epilepsy#first_line_immunotherapy first line immunotherapy http://purl.obolibrary.org/obo/OGMS_0000114 immunotherapy procedure https://bio.scai.fraunhofer.de/ontology/epilepsy#second_line_immunotherapy second line immunotherapy http://purl.obolibrary.org/obo/OGMS_0000114 immunotherapy procedure http://purl.obolibrary.org/obo/BFO_0000001 entity https://bio.scai.fraunhofer.de/ontology/0000400 risk factor TM_BIN https://bio.scai.fraunhofer.de/ontology/0000402 diagnosis TM_BIN https://bio.scai.fraunhofer.de/ontology/0000404 sign and symptom TM_BIN https://bio.scai.fraunhofer.de/ontology/0000407 epilepsy syndrome TM_BIN https://bio.scai.fraunhofer.de/ontology/0000408 epilepsy imitator TM_BIN https://bio.scai.fraunhofer.de/ontology/0000411 etiology TM_BIN https://bio.scai.fraunhofer.de/ontology/0000413 seizure classification TM_BIN https://bio.scai.fraunhofer.de/ontology/0000415 treatment TM_BIN https://bio.scai.fraunhofer.de/ontology/0000417 anatomical entity TM_BIN https://bio.scai.fraunhofer.de/ontology/0000419 cellular process TM_BIN https://bio.scai.fraunhofer.de/ontology/epilepsy/brain_connectivity_TM_BIN Brain connectivity TM_BIN https://bio.scai.fraunhofer.de/ontology/epilepsy/epilepsy_classification_TM_BIN epilepsy classification TM_BIN https://bio.scai.fraunhofer.de/ontology/0000401 isRiskFactorFor https://bio.scai.fraunhofer.de/ontology/0000403 isDiagnosisFor https://bio.scai.fraunhofer.de/ontology/0000405 isSignAndSymptomFor https://bio.scai.fraunhofer.de/ontology/0000409 isSyndromeFor https://bio.scai.fraunhofer.de/ontology/0000410 isImitatorFor https://bio.scai.fraunhofer.de/ontology/0000412 isEtiologyFor https://bio.scai.fraunhofer.de/ontology/0000414 isSeizureClassificationFor https://bio.scai.fraunhofer.de/ontology/0000416 isTreatmentFor https://bio.scai.fraunhofer.de/ontology/0000418 isAnatomicalEntityFor https://bio.scai.fraunhofer.de/ontology/0000420 isCellularProcessFor https://bio.scai.fraunhofer.de/ontology/ac113c60_c3d8_48f2_871c_cc34524d844f isClassificationFor https://bio.scai.fraunhofer.de/ontology/cac13978_e4e8_4240_907f_80ddfd3af981 isBrainConnectivityFor