Term IRI	Term label	Parent term IRI	Parent term label	Alternative term	Definition
http://purl.obolibrary.org/obo/IAO_0000027	data item	http://purl.obolibrary.org/obo/IAO_0000030	information content entity	data	An information content entity that is intended to be a truthful statement about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements.
http://purl.obolibrary.org/obo/INO_0000114	overexpression	http://purl.obolibrary.org/obo/INO_0000102	gene expression	overexpression	a gene expression that has increased volume. 
http://purl.obolibrary.org/obo/INO_0000113	macrophage-pathogen protein-protein interaction	http://purl.obolibrary.org/obo/INO_0000109	macrophage-pathogen interaction	macrophage-pathogen PPI	A macrophage-pathogen interaction that involves a macrophage protein and a pathogen protein.
http://purl.obolibrary.org/obo/INO_0000009	input interactor role	http://purl.obolibrary.org/obo/INO_0000015	interactor role	interaction input role	an interactor role that is borne by a material entity that acts as an input of an interaction.
http://purl.obolibrary.org/obo/INO_0000010	output interactor role	http://purl.obolibrary.org/obo/INO_0000015	interactor role	interaction output role	an interactor role that is borne by a material entity that acts as an output of an interaction.
http://purl.obolibrary.org/obo/INO_0000028	protein activation by mutant	http://purl.obolibrary.org/obo/INO_0000026	protein activation	protein activation by gene mutant	an activation process where one protein is activated by a gene mutant
http://purl.obolibrary.org/obo/INO_0000032	regulation of transcription	http://purl.obolibrary.org/obo/INO_0000044	gene expression regulation	regulation of gene transcription	a gene expression regulation process that involves the regulation of a gene transcription.
http://purl.obolibrary.org/obo/INO_0000034	regulation of translation	http://purl.obolibrary.org/obo/INO_0000044	gene expression regulation	regulation of protein translation	a gene expression regulation process that involves the regulation of a protein translation process.
http://purl.obolibrary.org/obo/INO_0000044	gene expression regulation	http://purl.obolibrary.org/obo/INO_0000157	regulation	regulation of gene expression	a regulation process that regulates gene expression level
http://purl.obolibrary.org/obo/INO_0000045	protein translation	http://purl.obolibrary.org/obo/INO_0000102	gene expression	gene translation	a gene expression process that results in protein production from a gene DNA sequence. 
http://purl.obolibrary.org/obo/INO_0000048	coimmunoprecipitation	http://purl.obolibrary.org/obo/INO_0000060	coprecipitation	co-immunoprecipitation	a coprecipitation that occurs through an immunoprecipitation process.
http://purl.obolibrary.org/obo/INO_0000055	regulation of protein activity	http://purl.obolibrary.org/obo/INO_0000157	regulation	protein activity regulation	a regulation process that regulates an activity of a protein
http://purl.obolibrary.org/obo/INO_0000056	downexpression	http://purl.obolibrary.org/obo/INO_0000102	gene expression	decreased gene expression	a gene expression that has decreased volume. 
http://purl.obolibrary.org/obo/INO_0000060	coprecipitation	http://purl.obolibrary.org/obo/MI_0403	colocalization	co-precipitation	a colocalization that two interactors are precipitated together.
http://purl.obolibrary.org/obo/INO_0000067	negative regulation of protein activity	http://purl.obolibrary.org/obo/INO_0000055	regulation of protein activity	negative protein activity regulation	a regulation of protein activitiy process that involves a negative regulation
http://purl.obolibrary.org/obo/INO_0000073	decrease	http://purl.obolibrary.org/obo/INO_0000068	negative regulation	reduction	a negative regulation that results in the decrease of one interactor volume. 
http://purl.obolibrary.org/obo/INO_0000104	positive regulation of protein activity	http://purl.obolibrary.org/obo/INO_0000055	regulation of protein activity	negative protein activity regulation	a regulation of protein activitiy process that involves a positive regulation
http://purl.obolibrary.org/obo/INO_0000120	increase	http://purl.obolibrary.org/obo/INO_0000117	positive regulation	enhancement	a positive regulation that leads to the increase of a quality of an entity.
http://purl.obolibrary.org/obo/INO_0000122	induction	http://purl.obolibrary.org/obo/INO_0000117	positive regulation	triggering	a positive regulation that leads to the induction of a new interactor due to the presence of another interactor. 
http://purl.obolibrary.org/obo/CHEBI_23367	molecular entity	http://purl.obolibrary.org/obo/BFO_0000040	material entity		Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity.
http://purl.obolibrary.org/obo/BFO_0000004	independent continuant	http://purl.obolibrary.org/obo/BFO_0000002	continuant		b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002])
http://purl.obolibrary.org/obo/BFO_0000015	process	http://purl.obolibrary.org/obo/BFO_0000003	occurrent		p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003])
http://purl.obolibrary.org/obo/BFO_0000020	specifically dependent continuant	http://purl.obolibrary.org/obo/BFO_0000002	continuant		b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003])
http://purl.obolibrary.org/obo/BFO_0000023	role	http://purl.obolibrary.org/obo/BFO_0000017	realizable entity		A realizable entity  the manifestation of which brings about some result or end that is not essential to a continuant  in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant  in some kinds of natural, social or institutional contexts.
http://purl.obolibrary.org/obo/BFO_0000031	generically dependent continuant	http://purl.obolibrary.org/obo/BFO_0000002	continuant		b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001])
http://purl.obolibrary.org/obo/BFO_0000040	material entity	http://purl.obolibrary.org/obo/BFO_0000004	independent continuant		An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time.
http://purl.obolibrary.org/obo/IAO_0000030	information content entity	http://purl.obolibrary.org/obo/BFO_0000031	generically dependent continuant		A generically dependent continuant that is about some thing.
http://purl.obolibrary.org/obo/PR_000000001	protein	http://purl.obolibrary.org/obo/CHEBI_23367	molecular entity		An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof.
http://purl.obolibrary.org/obo/MI_2280	deamidation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Reaction in which an amide functional group in the side chain of the amino acids asparagine or glutamine is removed or converted to another functional group. Typically, asparagine is converted to aspartic acid or isoaspartic acid and glutamine is converted to glutamic acid or pyroglutamic acid (5-oxoproline).
http://purl.obolibrary.org/obo/CHEBI_16991	deoxyribonucleic acid	http://purl.obolibrary.org/obo/CHEBI_33696	nucleic acid		High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms.
http://purl.obolibrary.org/obo/CHEBI_33696	nucleic acid	http://purl.obolibrary.org/obo/CHEBI_23367	molecular entity		A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid.
http://purl.obolibrary.org/obo/CL_0000000	cell	http://purl.obolibrary.org/obo/BFO_0000040	material entity		A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.
http://purl.obolibrary.org/obo/CL_0000066	epithelial cell	http://purl.obolibrary.org/obo/CL_0000000	cell		A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina.
http://purl.obolibrary.org/obo/CL_0000235	macrophage	http://purl.obolibrary.org/obo/CL_0000000	cell		A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.
http://purl.obolibrary.org/obo/OGG_0000000002	gene	http://purl.obolibrary.org/obo/BFO_0000040	material entity		A gene is a material entity that represents the entire DNA sequence required for synthesis of a functional protein or RNA molecule. 
http://purl.obolibrary.org/obo/CHEBI_33697	ribonucleic acid	http://purl.obolibrary.org/obo/CHEBI_33696	nucleic acid		High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins.
http://purl.obolibrary.org/obo/GO_0006473	protein acetylation	http://purl.obolibrary.org/obo/INO_0000022	up-regulation of secretion		The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.
http://purl.obolibrary.org/obo/GO_0016310	phosphorylation	http://purl.obolibrary.org/obo/INO_0000007	up-regulation		The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
http://purl.obolibrary.org/obo/GO_0018377	protein myristoylation	http://purl.obolibrary.org/obo/MI_0211	lipid addition		The covalent attachment of a myristoyl group to a protein.
http://purl.obolibrary.org/obo/INO_0000102	gene expression	http://purl.obolibrary.org/obo/INO_0000002	interaction		a biological interaction that uses the information from a gene to synthesize a functional gene product. 
http://purl.obolibrary.org/obo/IDO_0000629	host role	http://purl.obolibrary.org/obo/BFO_0000023	role		A role borne by an organism in virtue of the fact that it's extended organism contains a material entity other than the organism.
http://purl.obolibrary.org/obo/PW_0000001	pathway	http://purl.obolibrary.org/obo/INO_0000001	interaction network		A pathway is a set of inter-connected  reactions and interactions whose delineation and scope are used as a model for exploring and studying, describing and understanding the working of and relationships between biomolecules within a context.
http://purl.obolibrary.org/obo/PW_0000002	classic metabolic pathway	http://purl.obolibrary.org/obo/INO_0000003	pathway		The various, enzyme controlled, series of reactions allowing for the conversion of materials, energy availability and biodegradation of xenobiotics.
http://purl.obolibrary.org/obo/PW_0000003	signaling pathway	http://purl.obolibrary.org/obo/INO_0000003	pathway		The pathways where a signal - hormone, neurotransmitter, growth factor, peptide, any molecule - triggers one or multiple cascades of events. This involves a number of molecules, including receptors, proteins, ligands, messengers, any participating molecule. A signaling pathway may be upstream or downstream of other signaling pathways. Signaling pathways control a very broad spectrum of processes as well as pathways.
http://purl.obolibrary.org/obo/PW_0000004	regulatory pathway	http://purl.obolibrary.org/obo/INO_0000003	pathway		The pathways that control the processes by which a cell or organism develops, adjusts, behaves, responds to conditions or changes in these conditions, or in any manner helps promote and maintain its efficient functioning.
http://purl.obolibrary.org/obo/PW_0000013	disease pathway	http://purl.obolibrary.org/obo/INO_0000003	pathway		Complex human diseases encompass a spectrum of genetic and environmental attributes that together affect the normal functioning of several molecular and cellular pathways. Their combined and accumulated effect is manifested in the anomalous phenotype of the complex condition.
http://purl.obolibrary.org/obo/PW_0000754	drug pathway	http://purl.obolibrary.org/obo/INO_0000003	pathway		The pharmacokinetics and the pharmacodynamics pathway elicited by the administration of specific drugs. The systems involved in drug processing and responses are also those handling exogenous, xenobiotic compounds in the cellular detoxification pathway. The distinction between a random encounter with a foreign compound and the processing of a substance administered for treatment along with the importance of genetic variation for the individual responses to particular drugs warrant their separate consideration.
http://purl.obolibrary.org/obo/MI_0192	acetylation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Reaction, that can affect K,C,A,D,E,Q,G,I,K,M,P,S,T,Y,V residues.
http://purl.obolibrary.org/obo/MI_0193	amidation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Irreversible reaction that can affect A,R,N,D,C,Q,E,G,H,I,L,K,M,F,P,S,T,W,Y or V residues. It involves the addition of an amide group from a glycine to the target residue.
http://purl.obolibrary.org/obo/MI_0194	cleavage reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Covalent bond breakage in a molecule leading to the formation of smaller molecules.
http://purl.obolibrary.org/obo/MI_0195	covalent binding	http://purl.obolibrary.org/obo/MI_0407	direct interaction		Interaction leading to the formation of covalent bond within an autocatalytic molecule or between partners.
http://purl.obolibrary.org/obo/MI_0197	deacetylation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		N6-acetyl-L-lysine or S-acetyl-L-cysteine are cleaved and return K or C residues.
http://purl.obolibrary.org/obo/MI_0198	defarnesylation reaction	http://purl.obolibrary.org/obo/MI_0212	lipoprotein cleavage reaction		S-farnesyl-L-cysteined is cleaved and returns a C residue.
http://purl.obolibrary.org/obo/MI_0199	deformylation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		N6-formyl-L-lysine is cleaved and returns a K residue.
http://purl.obolibrary.org/obo/MI_0200	degeranylation reaction	http://purl.obolibrary.org/obo/MI_0212	lipoprotein cleavage reaction		S-geranylgeranyl-L-cysteine is cleaved and returns a C residue.
http://purl.obolibrary.org/obo/MI_0201	demyristoylation reaction	http://purl.obolibrary.org/obo/MI_0212	lipoprotein cleavage reaction		N6-myristoyl-L-lysine is cleaved and returns a K residue.
http://purl.obolibrary.org/obo/MI_0202	depalmitoylation reaction	http://purl.obolibrary.org/obo/MI_0212	lipoprotein cleavage reaction		S-palmitoyl-L-cysteine, N6-palmitoyl-L-lysine, O-palmitoyl-L-threonine or O-palmitoyl-L-serine are cleaved and return C,K,T or S residues.
http://purl.obolibrary.org/obo/MI_0203	dephosphorylation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Phosphoresidues are cleaved and return D,C,H,S,T,Y or R residues.
http://purl.obolibrary.org/obo/MI_0204	deubiquitination reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Cleavage of the G-K bond and release of ubiquitin or ubiquitin like proteins.
http://purl.obolibrary.org/obo/MI_0206	farnesylation reaction	http://purl.obolibrary.org/obo/MI_0211	lipid addition		Reversible reaction that can affect C residue.
http://purl.obolibrary.org/obo/MI_0207	formylation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Reaction that can affect K or G residues. Reside is functionalised with a formyl group.
http://purl.obolibrary.org/obo/MI_0208	genetic interaction	http://purl.obolibrary.org/obo/INO_0000002	interaction		An effect in which two genetic perturbations, when combined, result in a phenotype that does not appear to be merely explained by the superimposition or addition of effects of the original perturbations.
ab (not=) E
http://purl.obolibrary.org/obo/MI_0209	geranylgeranylation reaction	http://purl.obolibrary.org/obo/MI_0211	lipid addition		Attachment of one or two 20-carbon lipophilic geranylgeranyl isoprene units from geranylgeranyl diphosphate to one or more cysteine residue(s).Reversible reaction that can affect C residue.
http://purl.obolibrary.org/obo/MI_0210	hydroxylation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Irreversible introduction of a hydroxyl group that can affect K,P,Y or R residues. Hydroxylation is the first step in the oxidative degeneration of organic compounds.
http://purl.obolibrary.org/obo/MI_0211	lipid addition	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Covalent or non covalent binding of lipid group on a protein residue.
http://purl.obolibrary.org/obo/MI_0212	lipoprotein cleavage reaction	http://purl.obolibrary.org/obo/MI_0194	cleavage reaction		Cleavage of a lipid group covalently bound to a protein residue.
http://purl.obolibrary.org/obo/MI_0213	methylation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer. Irreversible reaction that can affect A,G,M,F,P,C,R,N,Q,E,H,or K residues.
http://purl.obolibrary.org/obo/MI_0214	myristoylation reaction	http://purl.obolibrary.org/obo/MI_0211	lipid addition		Irreversible covalent addition of a myristoyl group via an amide bond to the alpha-amino group of an amino acid. Reaction that can affect K or G residues.
http://purl.obolibrary.org/obo/MI_0216	palmitoylation reaction	http://purl.obolibrary.org/obo/MI_0211	lipid addition		Covalent attachment of palmitic acid to the cysteine residues of membrane proteins. Reversible reaction that can affect C,K,T or S residues.
http://purl.obolibrary.org/obo/MI_0217	phosphorylation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Reversible reaction that can affect D,C,H,S,T,Y,R residues.
http://purl.obolibrary.org/obo/MI_0220	ubiquitination reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Reversible reaction that create a covalent bond between a C-terminus G of ubiquitin and a K residue of the target.
http://purl.obolibrary.org/obo/MI_0403	colocalization	http://purl.obolibrary.org/obo/INO_0000002	interaction		Coincident occurrence of molecules in a given subcellular fraction observed with a low resolution methodology from which a physical interaction among those molecules cannot be inferred.
http://purl.obolibrary.org/obo/MI_0407	direct interaction	http://purl.obolibrary.org/obo/MI_0915	physical association		Interaction between molecules that are in direct contact with each other.
http://purl.obolibrary.org/obo/MI_0408	disulfide bond	http://purl.obolibrary.org/obo/MI_0195	covalent binding		Covalent bond mediated by 2 sulfur atoms.
http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction	http://purl.obolibrary.org/obo/MI_0407	direct interaction		terms aiming to represent biochemical reactions referring to their resulting product modifications.
http://purl.obolibrary.org/obo/MI_0556	transglutamination reaction	http://purl.obolibrary.org/obo/MI_0195	covalent binding		Gln-Lys cross-link catalyzed by a transglutaminase.
http://purl.obolibrary.org/obo/MI_0557	adp ribosylation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Involves the addition of one or more ADP-ribose moieties to proteins. Reaction that can affect Arg, Cys, Glu, Arg and Asn residues.
http://purl.obolibrary.org/obo/MI_0558	deglycosylation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Reaction catalyzed by PNGase, a deglycosylating enzyme that promotes the hydrolysis of the beta-aspartylglycosylamine bond of aspargine-linked glycopeptides and glycoproteins.
http://purl.obolibrary.org/obo/MI_0559	glycosylation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological polymer. Reaction that can affect Ser, Thr, Cys, Arg, and Asn residues. This reaction is known to be reversible in the case of Asn substrate.
http://purl.obolibrary.org/obo/MI_0566	sumoylation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Reversible reaction that create a covalent bond between a C-terminus G of an ubiquitine like sumo protein and a K residue of the target.
http://purl.obolibrary.org/obo/MI_0567	neddylation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Reversible reaction that create a covalent bond between a Glycine residue of an ubiquitine like NEDD8 protein and a lysine residue of the target.
http://purl.obolibrary.org/obo/MI_0568	desumoylation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Cleavage of the G-K bond and release of the SUMO ubiquitin like proteins.
http://purl.obolibrary.org/obo/MI_0569	deneddylation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Cleavage of the G-K bond and release of the NEDD8 ubiquitin like proteins. Deneddylation, which removes the NEDD8 moiety, requires the isopeptidase activity of the COP9 signalosome.
http://purl.obolibrary.org/obo/MI_0570	protein cleavage	http://purl.obolibrary.org/obo/MI_0194	cleavage reaction		Covalent modification of a polypeptide occuring during its maturation or its proteolytic degradation.
http://purl.obolibrary.org/obo/MI_0571	mrna cleavage	http://purl.obolibrary.org/obo/MI_0902	rna cleavage		Any process by which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner.
http://purl.obolibrary.org/obo/MI_0572	dna cleavage	http://purl.obolibrary.org/obo/MI_0910	nucleic acid cleavage		Covalent bond breakage of a DNA molecule leading to the formation of smaller fragments.
http://purl.obolibrary.org/obo/MI_0701	dna strand elongation	http://purl.obolibrary.org/obo/MI_0986	nucleic acid strand elongation reaction		The process by which a DNA strand is synthesized from template DNA by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand.
http://purl.obolibrary.org/obo/MI_0794	synthetic	http://purl.obolibrary.org/obo/MI_0933	negative genetic interaction		An effect in which two genetic perturbations, when combined, result in a mutant phenotype that is not observed (to any degree) as a result of any of the individual perturbations.
wt = a = b = E (not=) ab
http://purl.obolibrary.org/obo/MI_0795	asynthetic	http://purl.obolibrary.org/obo/MI_0935	positive genetic interaction		An effect in which individual perturbations of different genes and their combination result in the same mutant phenotype, to the same degree of severity/penetrance. With respect to any single quantifiable phenotype, this may be expressed as an inequality as: 
a = b = ab != wt
where 'a' and 'b' are the observed phenotype values of the individual perturbations, 'ab' is the observed phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_0796	suppression	http://purl.obolibrary.org/obo/MI_0935	positive genetic interaction		An effect in which two genetic perturbations, when combined, result in a phenotype that is less severe/penetrant than the most severe phenotype of the original perturbations, in effect making the organism more "wild type" in character with regards to the phenotype in question. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
a* < ab <= wt [E = a*]
OR
wt <= ab < a* [E = a*]
where 'a*' is the most severe observed phenotype value of the individual perturbations, 'ab' is the observed phenotype value of the double perturbation, 'E' is the expected phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_0797	epistasis	http://purl.obolibrary.org/obo/MI_0208	genetic interaction		An effect in which individual perturbations of two different genes result in different mutant phenotypes, and the resulting phenotype of their combination (the double mutant) is equal to that of only one of the perturbations. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
(a != wt AND b != wt AND a != b) AND (ab = a OR ab = b)
where 'a' and 'b' are the observed phenotype values of the individual perturbations, 'ab' is the observed phenotype value of the double perturbation, 'wt' is the wild type phenotype value and 'a != b' indicates qualitatively or quantitatively different phenotypes.
http://purl.obolibrary.org/obo/MI_0844	phosphotransfer reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Reaction where a phosphate is transferred between two proteins of a phosphorelay system.
http://purl.obolibrary.org/obo/MI_0871	demethylation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		The cleavage of a methyl group from a polypeptide. Methylation is generally an irreversible reaction except in mamalian.
http://purl.obolibrary.org/obo/MI_0881	nucleoside triphosphatase reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Catalysis of the hydrolysis of a  nucleoside triphosphate into a nucleoside diphosphate plus phosphate.
http://purl.obolibrary.org/obo/MI_0882	atpase reaction	http://purl.obolibrary.org/obo/MI_0881	nucleoside triphosphatase reaction		Catalysis of the hydrolisis of ATP+ H2O = ADP + phosphate.
http://purl.obolibrary.org/obo/MI_0883	gtpase reaction	http://purl.obolibrary.org/obo/MI_0881	nucleoside triphosphatase reaction		Catalysis of the hydrolisis of GTP+ H2O = GDP + phosphate.
http://purl.obolibrary.org/obo/MI_0902	rna cleavage	http://purl.obolibrary.org/obo/MI_0910	nucleic acid cleavage		Any process by which an RNA molecule is cleaved at specific sites or in a regulated manner.
http://purl.obolibrary.org/obo/MI_0910	nucleic acid cleavage	http://purl.obolibrary.org/obo/MI_0194	cleavage reaction		Covalent bond breakage of a nucleic acid molecule leading to the formation of smaller fragments.
http://purl.obolibrary.org/obo/MI_0914	association	http://purl.obolibrary.org/obo/INO_0000002	interaction		Interaction between molecules that may participate in formation of one, but possibly more, physical complexes. Often describes a set of molecules that are co-purified in a single pull-down or coimmunoprecipitation but might participate in formation of distinct physical complexes sharing a common bait.
http://purl.obolibrary.org/obo/MI_0915	physical association	http://purl.obolibrary.org/obo/MI_0914	association		Interaction between molecules within the same physical complex. Often identified under conditions which suggest that the molecules are in close proximity but not necessarily in direct contact with each other.
http://purl.obolibrary.org/obo/MI_0932	noninteractive	http://purl.obolibrary.org/obo/MI_0934	neutral genetic interaction		The observation that, when tested, no interaction was observed between two or more genes, for a given phenotype. In other words, the phenotype of the combined perturbations a and b result in the expected phenotype.
http://purl.obolibrary.org/obo/MI_0933	negative genetic interaction	http://purl.obolibrary.org/obo/MI_0208	genetic interaction		An effect in which two genetic perturbations, when combined, result in a phenotype that is more severe/penetrant than expected given the phenotypes of the individual perturbations. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
ab < E <= wt
OR
wt <= E < ab
where 'ab' is the observed phenotype value of the double perturbation, 'E' is the expected phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_0934	neutral genetic interaction	http://purl.obolibrary.org/obo/MI_0208	genetic interaction		An effect in which the observed phenotype of individual perturbations and/or the double perturbation collectively exhibit values both greater than AND less than wild type (on the same scale). Alternatively, this could describe a scenario in which individual perturbations result in qualitatively different phenotypes. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
a < wt < b [ab != E]
OR
With respect to two qualitatively different phenotypes, this may be expressed as an inequality as: 
(a != wt AND b != wt AND a != b)
where 'a' and 'b' are the observed phenotype values of the individual perturbations, 'ab' is the observed phenotype value of the double perturbation, 'E' is the expected phenotype value of the double perturbation, 'wt' is the wild type phenotype value and 'a != b' indicates qualitatively different phenotypes.
http://purl.obolibrary.org/obo/MI_0935	positive genetic interaction	http://purl.obolibrary.org/obo/MI_0208	genetic interaction		An effect in which two genetic perturbations, when combined, result in a phenotype that is less severe/penetrant than would be expected from the original phenotypes, in effect making the organism more "wild type" in character with regards to the phenotype in question. With respect to any single quantifiable phenotype, this may be expressed as an inequality as: 
E < ab <= wt
OR
wt <= ab < E
where 'ab' is the observed phenotype value of the double perturbation, 'E' is the expected phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_0945	oxidoreductase activity electron transfer reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		An oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
http://purl.obolibrary.org/obo/MI_0971	phosphopantetheinylation	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		The posttranslational phosphopantetheinylation of peptidyl-serine to form peptidyl-O-phosphopantetheine-L-serine.
http://purl.obolibrary.org/obo/MI_0985	deamination reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		The removal of an amine group from a molecule.
http://purl.obolibrary.org/obo/MI_0986	nucleic acid strand elongation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		The lengthening of a strand of a nucleic acid by the systematic addition of bases by a polymerase.
http://purl.obolibrary.org/obo/MI_0987	rna strand elongation	http://purl.obolibrary.org/obo/MI_0986	nucleic acid strand elongation reaction		The process by which an RNA strand is synthesized from template DNA by the action of polymerases, which add nucleotides to the 3' end of the nascent RNA strand.
http://purl.obolibrary.org/obo/MI_1027	diphtamidation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		A modification that converts an L-histidine residue to diphthamide.
http://purl.obolibrary.org/obo/MI_1110	predicted interaction	http://purl.obolibrary.org/obo/INO_0000002	interaction		Interaction has been predicted by either interologue mapping, by an algorithm or by a computational method.
http://purl.obolibrary.org/obo/MI_1126	self interaction	http://purl.obolibrary.org/obo/MI_0407	direct interaction		Intra-molecular interaction between two or more regions of the same molecule.
http://purl.obolibrary.org/obo/MI_1127	putative self interaction	http://purl.obolibrary.org/obo/MI_0407	direct interaction		Interaction between two or more regions of possibly the same molecule but it is also possible that the observation is due to an interaction between two identical molecules.
http://purl.obolibrary.org/obo/MI_1139	carboxylation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Carboxylation is a posttranslational modification of glutamate residues, to gamma-carboxyglutamate, in proteins.
http://purl.obolibrary.org/obo/MI_1140	decarboxylation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Decarboxylation is a chemical reaction that releases carbon dioxide (CO2). Usually, decarboxylation refers to a reaction of carboxylic acids, removing a carbon atom from a carbon chain. Enzymes that catalyze decarboxylations are called decarboxylases or, the more formal term, carboxy-lyases (EC number 4.1.1).
http://purl.obolibrary.org/obo/MI_1143	aminoacylation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Aminoacylation is the process of adding an aminoacyl group to a compound.
http://purl.obolibrary.org/obo/MI_1146	phospholipase reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Measurement of the hydrolysis of phospholipids into fatty acids and other lipophilic substances. There are four major classes, termed A, B, C and D, distinguished by the type of reaction which they catalyze.
http://purl.obolibrary.org/obo/MI_1148	ampylation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		AMPylation, previously known as adenylylation, is formation of a
phosphodiester or phosphoramide ester of AMP on Tyr (RESID:AA0203), Lys
(RESID:AA0227), Thr (RESID:AA0267), His (RESID:AA0371) and other amino
acids.
http://purl.obolibrary.org/obo/MI_1230	uridylation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		The formation of a phosphodiester or phosphoramide ester of UMP and amino acid (MOD:01166).
http://purl.obolibrary.org/obo/MI_1237	proline isomerization  reaction	http://purl.obolibrary.org/obo/MI_1250	isomerase reaction		The conversion between cis- and trans- peptide bonds formed by the amine group of a proline.
http://purl.obolibrary.org/obo/MI_1250	isomerase reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		The catalysis of the structural rearrangement of isomers.
http://purl.obolibrary.org/obo/MI_1251	methylmalonyl-CoA isomerase reaction	http://purl.obolibrary.org/obo/MI_1250	isomerase reaction		The catalysis of the conversion of methylmalonyl-CoA to succinyl-CoA by transfer of the carbonyl group. It requires a cobamide coenzyme. EC 5.4.99.2.
http://purl.obolibrary.org/obo/MI_1271	enhancement	http://purl.obolibrary.org/obo/MI_0933	negative genetic interaction		An effect in which the phenotype of one genetic perturbation is enhanced by a second perturbation to a severity/penetrance beyond (further from wild type) that expected by the superimposition or addition of effects of the individual perturbations. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
ab < E < wt
OR
wt < E < ab
where 'ab' is the observed phenotype value of the double perturbation, 'E' is the expected phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_1272	positive epistasis	http://purl.obolibrary.org/obo/MI_0935	positive genetic interaction		An effect in which individual perturbations of two different genes result in different mutant phenotypes (which are traits measured on the same quantitative scale but each significantly deviating, in the same direction, from wild type), and the resulting phenotype of their combination is equal to that of only one of the perturbations. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
((a* < b < wt) OR (wt < b < a*)) AND (ab = a OR ab = b)
where 'a' and 'b' are the observed phenotype values of the individual perturbations ('a*' being the most severe of the two), 'ab' is the observed phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_1273	maximal epistasis	http://purl.obolibrary.org/obo/MI_1284	quantitative epistasis		An effect in which individual perturbations of two different genes result in the same mutant phenotype to varying degrees of severity/penetrance and the resulting phenotype of their combination is equal in severity/penetrance to the most severe/penetrant of the individual perturbations. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
ab = a* < b < wt
OR
wt < b < a* = ab
where 'a' and 'b' are the observed phenotype values of the individual perturbations ('a*' being the most severe of the two), 'ab' is the observed phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_1274	minimal epistasis	http://purl.obolibrary.org/obo/MI_1284	quantitative epistasis		An effect in which individual perturbations of two different genes result in the same mutant phenotype to varying degrees of severity/penetrance and the resulting phenotype of their combination is equal in severity/penetrance to the least severe/penetrant of the individual perturbations. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
a* < ab = b < wt
OR
wt < b = ab < a*
where 'a' and 'b' are the observed phenotype values of the individual perturbations ('a*' being the most severe of the two), 'ab' is the observed phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_1275	neutral epistasis	http://purl.obolibrary.org/obo/MI_0934	neutral genetic interaction		An effect in which individual perturbations of two different genes result in different mutant phenotypes (which are EITHER traits measured on the same quantitative scale but each significantly deviating, in opposite directions, from wild type, OR completely (qualitatively) different phenotypes), and the resulting phenotype of their combination is equal to that of only one of the perturbations. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
(a < wt < b) AND (ab = a OR ab = b)
OR
(a != wt AND b != wt AND a != b) AND (ab = a OR ab = b)
where 'a' and 'b' are the observed phenotype values of the individual perturbations, 'ab' is the observed phenotype value of the double perturbation, 'wt' is the wild type phenotype value, and 'a != b' indicates qualitatively different phenotypes.
http://purl.obolibrary.org/obo/MI_1276	opposing epistasis	http://purl.obolibrary.org/obo/MI_1284	quantitative epistasis		An effect in which individual perturbations of two different genes result in opposite mutant phenotypes (traits measured on the same scale but each on opposing sides relative to the wild type phenotype), and the resulting phenotype of their combination is equal to that of only one of the perturbations. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
(a < wt < b) AND (ab = a OR ab = b) 
where 'a' and 'b' are the observed phenotype values of the individual perturbations, 'ab' is the observed phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_1277	qualitative epistasis	http://purl.obolibrary.org/obo/MI_1275	neutral epistasis		An effect in which individual perturbations of two different genes result in different mutant phenotypes (which are traits that cannot be measured on the same scale and, hence, qualitatively different), and the resulting phenotype of their combination is equal to that of only one of the perturbations. This may be expressed as an inequality as:
(a != wt AND b != wt AND a != b) AND (ab = a OR ab = b)    
where 'a' and 'b' are the observed phenotypes of the individual perturbations, 'ab' is the observed phenotype of the double perturbation, 'wt' is the wild type phenotype and 'a != b' indicates qualitatively different phenotypes.
http://purl.obolibrary.org/obo/MI_1278	mutual enhancement	http://purl.obolibrary.org/obo/MI_1271	enhancement		An effect in which individual perturbations of different genes result in the same mutant phenotype (but, perhaps, to varying degrees of severity/penetrance) and the resulting phenotype of their combination is more severe/penetrant (further from wild type) than expected by the superimposition or addition of effects of the individual perturbations. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
ab < a* <= b < wt [E = a*]
OR
wt < b <= a* < ab [E = a*]
where 'a' and 'b' are the observed phenotype values of the individual perturbations ('a*' being the most severe of the two), 'ab' is the observed phenotype value of the double perturbation, 'E' is the expected phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_1279	unilateral enhancement	http://purl.obolibrary.org/obo/MI_1271	enhancement		An effect in which the phenotype of one genetic perturbation is enhanced by a second perturbation (which, on its own, has no effect on the phenotype in question) to a severity/penetrance beyond (further from wild type) that of the original phenotype. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
ab < a < b = wt [E = a]
OR
wt = b < a < ab [E = a]
where 'a' and 'b' are the observed phenotype values of the individual perturbations, 'ab' is the observed phenotype value of the double perturbation, 'E' is the expected phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_1280	mutual suppression	http://purl.obolibrary.org/obo/MI_0796	suppression		An effect in which individual perturbations of different genes result in the same mutant phenotype (but, perhaps, to varying degrees of severity/penetrance) and the resulting phenotype of their combination is less severe/penetrant than expected from the original phenotypes. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
(a* <= b < wt) AND (a* < ab <= wt) [E = a*]
OR
(wt < b <= a*) AND (wt <= ab < a*) [E = a*]
where 'a' and 'b' are the observed phenotype values of the individual perturbations ('a*' being the most severe of the two), 'ab' is the observed phenotype value of the double perturbation, 'E' is the expected phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_1281	mutual suppression (complete)	http://purl.obolibrary.org/obo/MI_1280	mutual suppression		An effect in which individual perturbations of different genes result in the same mutant phenotype (but, perhaps, to varying degrees of severity/penetrance) and the resulting combination is wild type. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
a* <= b < ab = wt
OR
wt = ab < b <= a*
OR
a < wt = ab < b
where 'a' and 'b' are the observed phenotype values of the individual perturbations ('a*' being the most severe of the two), 'ab' is the observed phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_1282	mutual suppression (partial)	http://purl.obolibrary.org/obo/MI_1280	mutual suppression		An effect in which individual perturbations of different genes result in the same mutant phenotype (but, perhaps, to varying degrees of severity/penetrance) and the resulting phenotype of their combination is less severe/penetrant than expected, but not wild type. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
(a* <= b < wt) AND (a* < ab < wt) [E = a*]
OR
(wt < b <= a*) AND (wt < ab < a*) [E = a*]
where 'a' and 'b' are the observed phenotype values of the individual perturbations ('a*' being the most severe of the two), 'ab' is the observed phenotype value of the double perturbation, 'E' is the expected phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_1283	suppression-enhancement	http://purl.obolibrary.org/obo/MI_1282	mutual suppression (partial)		An effect in which individual perturbations of different genes result in the same mutant phenotype to varying degrees of severity/penetrance and the resulting phenotype of their combination has a phenotype more severe/penetrant than the least severe/penetrant and less severe/penetrant than the most severe/penetrant of the individual perturbations. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
a* < ab < b < wt [E = a*]
OR
wt < b < ab < a* [E = a*]
where 'a' and 'b' are the observed phenotype values of the individual perturbations ('a*' being the most severe of the two), 'ab' is the observed phenotype value of the double perturbation, 'E' is the expected phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_1284	quantitative epistasis	http://purl.obolibrary.org/obo/MI_0797	epistasis		An effect in which individual perturbations of two different genes result in different mutant phenotypes (which are traits measured on the same quantitative scale but each significantly deviating, in any direction, from wild type), and the resulting phenotype of their combination is equal to that of only one of the perturbations. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
(a != wt AND b != wt AND a != b) AND (ab = a OR ab = b)   
where 'a' and 'b' are the observed phenotype values of the individual perturbations, 'ab' is the observed phenotype value of the double perturbation, 'wt' is the wild type phenotype value and 'a != b' indicates quantitatively different phenotypes.
http://purl.obolibrary.org/obo/MI_1286	over-suppression	http://purl.obolibrary.org/obo/MI_0934	neutral genetic interaction		An effect in which the observed phenotype of a double perturbation is opposite (relative to the wild type phenotype) to that which is expected upon the double perturbation. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
ab < wt < E
OR
E < wt < ab
where 'ab' is the observed phenotype value of the double perturbation, 'E' is the expected phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_1287	mutual over-suppression	http://purl.obolibrary.org/obo/MI_1286	over-suppression		An effect in which individual perturbations of different genes result in the same mutant phenotype (but, perhaps, to varying degrees of severity/penetrance) and the resulting phenotype of their combination is opposite (relative to wild type) to that expected from the original phenotypes. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
a* <= b < wt < ab [E = a*]
OR
ab < wt < b <= a* [E = a*]
where 'a' and 'b' are the observed phenotype values of the individual perturbations ('a*' being the most severe of the two), 'ab' is the observed phenotype value of the double perturbation, 'E' is the expected phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_1288	over-suppression-enhancement	http://purl.obolibrary.org/obo/MI_0934	neutral genetic interaction		An effect in which two individual perturbations result in opposite mutant phenotypes (relative to wild type) and their combination results in a phenotype that is more severe than the phenotype observed with the same directionality. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
a < wt < b < ab
OR
ab < a < wt < b
where 'a' and 'b' are the observed phenotype values of the individual perturbations, 'ab' is the observed phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_1289	phenotype bias	http://purl.obolibrary.org/obo/MI_0934	neutral genetic interaction		An effect when two individual perturbations result in opposite mutant phenotypes (relative to wild type) and their combination results in a phenotype that is intermediate to the individual mutant phenotypes, but greater or less than wild type. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
(a < wt < b) AND (a < ab < b) AND (ab != wt)
where 'a' and 'b' are the observed phenotype values of the individual perturbations, 'ab' is the observed phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_1290	suppression (complete)	http://purl.obolibrary.org/obo/MI_0796	suppression		An effect in which the perturbation of one gene results in complete suppression (to wild type) of the mutant phenotype caused by perturbation of another gene. The phenotype of the suppressing perturbation may or may not be known. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
wt = ab != a = E
where 'a' is the observed phenotype values of an individual perturbation, 'ab' is the observed phenotype value of the double perturbation, 'E' is the expected phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_1291	suppression (partial)	http://purl.obolibrary.org/obo/MI_0796	suppression		An effect in which the perturbation of one gene results in the amelioration or lessening of the severity/penetrance of a mutant phenotype caused by perturbation of another gene, in effect making the organism more, but not completely, "wild type" in character with regards to the phenotype in question. The phenotype of the suppressing perturbation may or may not be known. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
a* < ab < wt [E = a*]
OR
wt < ab < a* [E = a*]
where 'a' and 'b' are the observed phenotype values of the individual perturbations ('a*' being the most severe of the two), 'ab' is the observed phenotype value of the double perturbation, 'E' is the expected phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_1292	unilateral suppression	http://purl.obolibrary.org/obo/MI_0796	suppression		An effect in which the perturbation of one gene, which has no effect on the phenotype in question, is combined with the perturbation of another gene, which causes the mutant phenotype in question, and results in the amelioration or lessening of the severity/penetrance of the mutant phenotype, in effect making the organism more "wild type" in character with regards to the phenotype in question. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
a < ab <= b = wt [E = a]
OR
wt = b <= ab < a [E = a]
where 'a' and 'b' are the observed phenotype values of the individual perturbations, 'ab' is the observed phenotype value of the double perturbation, 'E' is the expected phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_1293	unilateral suppression (complete)	http://purl.obolibrary.org/obo/MI_1292	unilateral suppression		An effect in which the perturbation of one gene, which has no effect on the phenotype in question, is combined with the perturbation of another gene, which causes the mutant phenotype in question, and results in the complete suppression (to wild type) of the mutant phenotype. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
a < ab = b = wt [E = a]
OR
wt = b = ab < a [E = a]
where 'a' and 'b' are the observed phenotype values of the individual perturbations, 'ab' is the observed phenotype value of the double perturbation, 'E' is the expected phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_1294	unilateral suppression (partial)	http://purl.obolibrary.org/obo/MI_1292	unilateral suppression		An effect in which the perturbation of one gene, which has no effect on the phenotype in question, is combined with the perturbation of another gene, which causes the mutant phenotype in question, and results in the amelioration or lessening of the severity/penetrance of the mutant phenotype, in effect making the organism more, but not completely, "wild type" in character with regards to the phenotype in question. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
a < ab < b = wt [E = a]
OR
wt = b < ab < a [E = a]
where 'a' and 'b' are the observed phenotype values of the individual perturbations, 'ab' is the observed phenotype value of the double perturbation, 'E' is the expected phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_1295	unilateral over-suppression	http://purl.obolibrary.org/obo/MI_1286	over-suppression		An effect in which the perturbation of one gene (which has no individual effect on the phenotype in question), when combined with a perturbation of another gene (which causes the phenotype in question), results in a mutant phenotype opposite (relative to wild type) to that of the original phenotype. With respect to any single quantifiable phenotype, this may be expressed as an inequality as:
E = a < b = wt < ab
OR
ab < wt = b < a = E
where 'a' and 'b' are the observed phenotype values of the individual perturbations, 'ab' is the observed phenotype value of the double perturbation, 'E' is the expected phenotype value of the double perturbation, and 'wt' is the wild type phenotype value.
http://purl.obolibrary.org/obo/MI_1310	de-ADP-ribosylation reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Measure of  hydrolytic reactions that release ADP-ribose.
http://purl.obolibrary.org/obo/MI_1327	sulfurtransfer reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Reaction where a sulfate group is transferred between two proteins
http://purl.obolibrary.org/obo/MI_1355	lipid cleavage	http://purl.obolibrary.org/obo/MI_0194	cleavage reaction		Reaction monitoring the cleavage (hydrolysis) or a lipid molecule.
http://purl.obolibrary.org/obo/MI_2252	guanine nucleotide exchange factor reaction	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		The process mediated by guanine nucleotide exchange factors (GEFs) that catalyze the exchange of bound GDP with cytosolic GTP.
http://purl.obolibrary.org/obo/MI_2263	s-nitrosylation	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Reaction that create a covalent bond between a nitrogen monoxide group and the thiol group of cysteine.
http://purl.obolibrary.org/obo/MI_2272	tyrosinylation	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		Reversible reaction that add a tyrosine residue to an amino-acid.
http://purl.obolibrary.org/obo/MI_2273	tyrosination	http://purl.obolibrary.org/obo/MI_2272	tyrosinylation		Reversible reaction that add a tyrosine residues to the c-terminal end of alpha-tubulin.
http://purl.obolibrary.org/obo/INO_0000105	host-pathogen interaction	http://purl.obolibrary.org/obo/INO_0000002	interaction		An interaction that involves a host (host organism or host cell) and pathogen organism at a specific condition.
http://purl.obolibrary.org/obo/INO_0000107	host cell-pathogen interaction	http://purl.obolibrary.org/obo/INO_0000105	host-pathogen interaction		An host-pathogen interaction where the host is a cell.
http://purl.obolibrary.org/obo/INO_0000108	induction by binding to protein	http://purl.obolibrary.org/obo/INO_0000122	induction		an induction that is achieved by binding to a protein
http://purl.obolibrary.org/obo/INO_0000109	macrophage-pathogen interaction	http://purl.obolibrary.org/obo/INO_0000107	host cell-pathogen interaction		An host cell-pathogen interaction where the host cell is a macrophage.
http://purl.obolibrary.org/obo/INO_0000129	host gene mutant-pathogen interaction	http://purl.obolibrary.org/obo/INO_0000105	host-pathogen interaction		An host-pathogen interaction where the host is a gene mutant
http://purl.obolibrary.org/obo/INO_0000133	host	http://purl.obolibrary.org/obo/BFO_0000040	material entity		An organism bearing a host role.
http://purl.obolibrary.org/obo/INO_0000138	macrophage-pathogen PPI inducing cell death	http://purl.obolibrary.org/obo/INO_0000113	macrophage-pathogen protein-protein interaction		A macrophage-pathogen protein-protein interaction that induces cell death.
http://purl.obolibrary.org/obo/INO_0000143	host-pathogen mutant interaction	http://purl.obolibrary.org/obo/INO_0000105	host-pathogen interaction		An host-pathogen interaction where the pathogen is a gene mutant
http://purl.obolibrary.org/obo/INO_0000146	macrophage-pathogen interaction	http://purl.obolibrary.org/obo/INO_0000107	host cell-pathogen interaction		An host cell-pathogen interaction where the host is a macrophage cell
http://purl.obolibrary.org/obo/INO_0000152	epithelial cell-pathogen interaction	http://purl.obolibrary.org/obo/INO_0000107	host cell-pathogen interaction		An host cell-pathogen interaction where the host is an epithelial cell
http://purl.obolibrary.org/obo/GO_0006915	apoptotic process	http://purl.obolibrary.org/obo/GO_0012501	programmed cell death		A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
http://purl.obolibrary.org/obo/GO_0008150	biological_process	http://purl.obolibrary.org/obo/BFO_0000015	process		A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
http://purl.obolibrary.org/obo/GO_0012501	programmed cell death	http://purl.obolibrary.org/obo/GO_0008219	cell death		A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.
http://purl.obolibrary.org/obo/GO_0051259	protein complex oligomerization	http://purl.obolibrary.org/obo/GO_0008150	biological_process		The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
http://purl.obolibrary.org/obo/GO_0008219	cell death	http://purl.obolibrary.org/obo/GO_0008150	biological_process		Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
http://purl.obolibrary.org/obo/INO_0000001	interaction network	http://purl.obolibrary.org/obo/BFO_0000015	process		Interaction network is a process that includes a network of at least two interactions.
http://purl.obolibrary.org/obo/INO_0000002	interaction	http://purl.obolibrary.org/obo/BFO_0000015	process		Interaction is a processual entity that has two or more participants (i.e., interactors) that have an effect upon one another. 
http://purl.obolibrary.org/obo/INO_0000003	pathway	http://purl.obolibrary.org/obo/INO_0000001	interaction network		an interaction network that includes at least two interactions and has a start point(s) and an end point(s). 
http://purl.obolibrary.org/obo/INO_0000004	Bayesian network	http://purl.obolibrary.org/obo/INO_0000158	interaction network model		an interaction network model that is represented by a probabilistic graphical model (a type of statistical model) that represents a set of random variables and their conditional dependencies via a directed acyclic graph (DAG).
http://purl.obolibrary.org/obo/INO_0000005	regulator role	http://purl.obolibrary.org/obo/INO_0000015	interactor role		an regulator role that is borne by a material entity that regulates an interaction.
http://purl.obolibrary.org/obo/INO_0000007	up-regulation	http://purl.obolibrary.org/obo/INO_0000117	positive regulation		a positive regulation that one interactor up-regulates another.
http://purl.obolibrary.org/obo/INO_0000008	interaction regulator	http://purl.obolibrary.org/obo/INO_0000016	interactor		an interactor that regulates an interaction.
http://purl.obolibrary.org/obo/INO_0000011	activator role	http://purl.obolibrary.org/obo/INO_0000134	positive regulator role		a positive regulator role that is borne by a material entity that activates an interaction.
http://purl.obolibrary.org/obo/INO_0000012	mutual information network	http://purl.obolibrary.org/obo/INO_0000158	interaction network model		an interaction network model that is represented by at least two mutual information interactions.
http://purl.obolibrary.org/obo/INO_0000013	node	http://purl.obolibrary.org/obo/BFO_0000030	object		a node is an object that represents an interactor in a graph of an interaction or interaction network.
http://purl.obolibrary.org/obo/INO_0000014	edge	http://purl.obolibrary.org/obo/BFO_0000030	object		an edge is an object that represents a graphic line that links two interactors in an interaction. 
http://purl.obolibrary.org/obo/INO_0000015	interactor role	http://purl.obolibrary.org/obo/BFO_0000023	role		a role that is borne by a material entity to act as a participant in an interaction process.
http://purl.obolibrary.org/obo/INO_0000016	interactor	http://purl.obolibrary.org/obo/BFO_0000040	material entity		an interactor is a material entity that participates in an interaction.
http://purl.obolibrary.org/obo/INO_0000017	activator	http://purl.obolibrary.org/obo/INO_0000141	positive regulator		a positive interaction regulator that activates an interaction.
http://purl.obolibrary.org/obo/INO_0000018	organism-organism interaction	http://purl.obolibrary.org/obo/INO_0000002	interaction		a biological interaction that occurs in the organism level. 
http://purl.obolibrary.org/obo/INO_0000019	two-way interaction	http://purl.obolibrary.org/obo/INO_0000002	interaction		A two-way interaction is an interaction that includes two different directions among two interactors. 
http://purl.obolibrary.org/obo/INO_0000021	human molecular pathway	http://purl.obolibrary.org/obo/INO_0000003	pathway		a pathway that exists in human body.
http://purl.obolibrary.org/obo/INO_0000022	up-regulation of secretion	http://purl.obolibrary.org/obo/INO_0000007	up-regulation		an up-regulation that one interactor up-regulates the secretion of another interactor.
http://purl.obolibrary.org/obo/INO_0000023	human molecular interaction	http://purl.obolibrary.org/obo/INO_0000002	interaction		an interaction involving human molecules
http://purl.obolibrary.org/obo/INO_0000024	activation	http://purl.obolibrary.org/obo/INO_0000117	positive regulation		a positive regulation that one interactor activates another. 
http://purl.obolibrary.org/obo/INO_0000025	gene-cell interaction	http://purl.obolibrary.org/obo/INO_0000002	interaction		an interaction that includes a gene and a cell as interactors.
http://purl.obolibrary.org/obo/INO_0000026	protein activation	http://purl.obolibrary.org/obo/INO_0000024	activation		an activation process where one protein is activated by a material entity
http://purl.obolibrary.org/obo/INO_0000027	cell-cell interaction	http://purl.obolibrary.org/obo/INO_0000002	interaction		a biological interaction that involves two cells as interactors.
http://purl.obolibrary.org/obo/INO_0000029	antagonism	http://purl.obolibrary.org/obo/MI_0407	direct interaction		a biochemical binding where a substance binds to the same site an agonist would bind to without causing activation of the receptor
http://purl.obolibrary.org/obo/INO_0000030	gene-enviroment interaction	http://purl.obolibrary.org/obo/INO_0000002	interaction		an interaction that involves a gene and its environment (e.g., calcium in blood). 
http://purl.obolibrary.org/obo/INO_0000031	regulation of protein location	http://purl.obolibrary.org/obo/INO_0000157	regulation		a regulation process that regulates the location of a protein
http://purl.obolibrary.org/obo/INO_0000033	attenuation	http://purl.obolibrary.org/obo/INO_0000068	negative regulation		a negative regulation that attenuates the virulence of a pathogenic microbe. 
http://purl.obolibrary.org/obo/INO_0000035	autophosphorylation	http://purl.obolibrary.org/obo/GO_0016310	phosphorylation		a phosphorylation process that adds a phosphate to a protein kinase (possibly affecting its activity) by virtue of its own enzymic activity. 
http://purl.obolibrary.org/obo/INO_0000037	regulation of gene activation	http://purl.obolibrary.org/obo/INO_0000157	regulation		a regulation process that regulates the activation of a gene so that the gene is expressed at a particular time
http://purl.obolibrary.org/obo/INO_0000038	positive regulation of gene expression	http://purl.obolibrary.org/obo/INO_0000044	gene expression regulation		a regulation process that positively regulates gene expression level
http://purl.obolibrary.org/obo/INO_0000039	negative regulation of gene expression	http://purl.obolibrary.org/obo/INO_0000044	gene expression regulation		a regulation process that negatively regulates gene expression level
http://purl.obolibrary.org/obo/INO_0000040	human biochemical reaction	http://purl.obolibrary.org/obo/INO_0000130	human molecular conversion		a human molecular reaction that is specifically a biochemical reaction
http://purl.obolibrary.org/obo/INO_0000042	negative regulation of gene transcription	http://purl.obolibrary.org/obo/INO_0000032	regulation of transcription		a negative regulation process that down-regulates gene expression level
http://purl.obolibrary.org/obo/INO_0000043	negative regulation of protein translation	http://purl.obolibrary.org/obo/INO_0000034	regulation of translation		a negative regulation process that down-regulates protein translation level
http://purl.obolibrary.org/obo/INO_0000046	inhibition of gene transcription	http://purl.obolibrary.org/obo/INO_0000042	negative regulation of gene transcription		a negative regulation of gene transcription process that specifiies the negative regulation being an inhibition.
http://purl.obolibrary.org/obo/INO_0000047	chemical reaction catalyst	http://purl.obolibrary.org/obo/INO_0000016	interactor		an interactor that starts or speeds up a chemical reaction while undergoing no permanent change itself.
http://purl.obolibrary.org/obo/INO_0000049	positive regulation of gene transcription	http://purl.obolibrary.org/obo/INO_0000032	regulation of transcription		a regulation of transcription process that inviolves a positive regulation.
http://purl.obolibrary.org/obo/INO_0000050	competition	http://purl.obolibrary.org/obo/MI_0914	association		an indirect association that one interactor competes with another interactor in a specfiic process. 
http://purl.obolibrary.org/obo/INO_0000051	activation of gene transcription	http://purl.obolibrary.org/obo/INO_0000049	positive regulation of gene transcription		a positive regulation of gene transcription process that inviolves an activation of the gene transcription.
http://purl.obolibrary.org/obo/INO_0000052	activation of gene transcription by low level protein	http://purl.obolibrary.org/obo/INO_0000051	activation of gene transcription		an activation of gene transcription that is achieved by a low level of a protein
http://purl.obolibrary.org/obo/INO_0000053	positive regulation of protein translation	http://purl.obolibrary.org/obo/INO_0000034	regulation of translation		a regulation of translation process that positively regulates protein translation level
http://purl.obolibrary.org/obo/INO_0000054	antigen-antibody interaction	http://purl.obolibrary.org/obo/MI_0407	direct interaction		a direct interaction where an antigen interacts with an antibody physically.
http://purl.obolibrary.org/obo/INO_0000057	controling	http://purl.obolibrary.org/obo/INO_0000086	dominant regulation		a regulation that one interactor controls the quality of another interactor to a specific range
http://purl.obolibrary.org/obo/INO_0000058	conversion	http://purl.obolibrary.org/obo/MI_0407	direct interaction		a direct physical association that one interactor is converted from another interactor. 
http://purl.obolibrary.org/obo/INO_0000059	cooperation	http://purl.obolibrary.org/obo/MI_0914	association		an indirect association that one interactor cooperates with another interactor in a specfiic process. 
http://purl.obolibrary.org/obo/INO_0000061	correlation	http://purl.obolibrary.org/obo/MI_0914	association		an indirect association that two interactors are correlated in a process without defined influence of each other. 
http://purl.obolibrary.org/obo/INO_0000063	cell-environment interaction	http://purl.obolibrary.org/obo/INO_0000002	interaction		an interaction that involves a cell and its environment as interactors
http://purl.obolibrary.org/obo/INO_0000064	cross-immunoprecipitation interaction	http://purl.obolibrary.org/obo/INO_0000116	immuno-precipitation		an immuno-precipitation that one interactor is precipitated based on an cross- immunological precipitation process.
http://purl.obolibrary.org/obo/INO_0000065	organism-environment interaction	http://purl.obolibrary.org/obo/INO_0000002	interaction		an interaction that involves an organism and its environment as interactors
http://purl.obolibrary.org/obo/INO_0000068	negative regulation	http://purl.obolibrary.org/obo/INO_0000157	regulation		a regulation in which one interactor has a negative effect on another interactor 
http://purl.obolibrary.org/obo/INO_0000069	chemical reaction catalyst role	http://purl.obolibrary.org/obo/INO_0000015	interactor role		an interactor role that is played by a material entity that starts or speeds up a chemical reaction while undergoing no permanent change itself.
http://purl.obolibrary.org/obo/INO_0000070	inhibition of protein activity	http://purl.obolibrary.org/obo/INO_0000067	negative regulation of protein activity		a negative regulation of protein activitiy process that involves an inhibition of a protein activity
http://purl.obolibrary.org/obo/INO_0000071	regulation of transcription by binding to promoter	http://purl.obolibrary.org/obo/INO_0000079	promoter-based regulation of transcription		a regulation of transcription process that occurs through the binding to a promotor of a gene
http://purl.obolibrary.org/obo/INO_0000072	positive regulation of transcription by binding to promoter	http://purl.obolibrary.org/obo/INO_0000071	regulation of transcription by binding to promoter		a regulation of transcription by binding to promoter that is further classified as a positive regulation
http://purl.obolibrary.org/obo/INO_0000074	negative regulation of transcription by binding to promoter	http://purl.obolibrary.org/obo/INO_0000071	regulation of transcription by binding to promoter		a regulation of transcription by binding to promoter that is further classified as a positive regulation
http://purl.obolibrary.org/obo/INO_0000075	gene activation	http://purl.obolibrary.org/obo/INO_0000038	positive regulation of gene expression		a positive regulation of gene expression process that activates a gene so that the gene is expressed at a particular time
http://purl.obolibrary.org/obo/INO_0000076	biochemical degradation	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		an enzymatic reaction that leads to the breakdown of a biochemical entity. 
http://purl.obolibrary.org/obo/INO_0000077	co-regulation of transcription	http://purl.obolibrary.org/obo/INO_0000032	regulation of transcription		a regulation of transcription process where two or more regulators regulate a gene transcription
http://purl.obolibrary.org/obo/INO_0000078	activation of gene transcription by high level protein	http://purl.obolibrary.org/obo/INO_0000051	activation of gene transcription		an activation of gene transcription that is achieved by a high level of a protein
http://purl.obolibrary.org/obo/INO_0000079	promoter-based regulation of transcription	http://purl.obolibrary.org/obo/INO_0000032	regulation of transcription		a regulation of transcription process through binding to a promoter or regulating the promoter binding activity
http://purl.obolibrary.org/obo/INO_0000081	activation of gene transcription by phosphorylated protein	http://purl.obolibrary.org/obo/INO_0000051	activation of gene transcription		an activation of gene transcription that is achieved by a phosphorylated protein
http://purl.obolibrary.org/obo/INO_0000084	destabilization	http://purl.obolibrary.org/obo/INO_0000068	negative regulation		a negative regulation that results in a destabilization. 
http://purl.obolibrary.org/obo/INO_0000085	gene expression inhibition	http://purl.obolibrary.org/obo/INO_0000039	negative regulation of gene expression		a negative regulation process that inhibits gene expression level
http://purl.obolibrary.org/obo/INO_0000086	dominant regulation	http://purl.obolibrary.org/obo/INO_0000157	regulation		a regulation that one interactor has a dominant effect on the quality of another interactor. This differs from the accessory regulation. 
http://purl.obolibrary.org/obo/INO_0000089	co-regulation	http://purl.obolibrary.org/obo/INO_0000157	regulation		a regulation process that involves in two interactors co-regulate a third interactor. 
http://purl.obolibrary.org/obo/INO_0000091	disruption	http://purl.obolibrary.org/obo/INO_0000068	negative regulation		a negative regulation that results in a disruption.
http://purl.obolibrary.org/obo/INO_0000093	down-regulation	http://purl.obolibrary.org/obo/INO_0000068	negative regulation		a negative regulation that one interactor down-regulates another.
http://purl.obolibrary.org/obo/INO_0000094	gene expression up-regulation	http://purl.obolibrary.org/obo/INO_0000038	positive regulation of gene expression		a positive regulation of gene expression process that up-regulates gene expression level
http://purl.obolibrary.org/obo/INO_0000095	gene expression down-regulation	http://purl.obolibrary.org/obo/INO_0000039	negative regulation of gene expression		a negative regulation process that down-regulates gene expression level
http://purl.obolibrary.org/obo/INO_0000096	induction of production	http://purl.obolibrary.org/obo/INO_0000122	induction		an induction that leads to the production of an entity
http://purl.obolibrary.org/obo/INO_0000097	elimination	http://purl.obolibrary.org/obo/INO_0000068	negative regulation		a negative regulation that one interactor eliminates another.
http://purl.obolibrary.org/obo/INO_0000098	bacterial conjugation	http://purl.obolibrary.org/obo/INO_0000027	cell-cell interaction		a cell-cell interaction that the transfers genetic material between bacterial cells by direct cell-to-cell contact or by a bridge-like connection between two cells.
http://purl.obolibrary.org/obo/INO_0000099	hydrogen binding	http://purl.obolibrary.org/obo/MI_0407	direct interaction		Interaction leading to the formation of hydrogen bond between two molecules
http://purl.obolibrary.org/obo/INO_0000100	regulation of assembly	http://purl.obolibrary.org/obo/INO_0000157	regulation		a regulation process where one gene product regulates an assembly process which forms an assembly having another gene product.
http://purl.obolibrary.org/obo/INO_0000101	human molecular control interaction	http://purl.obolibrary.org/obo/INO_0000023	human molecular interaction		a human molecular interaction where one molecule controls another molecule.
http://purl.obolibrary.org/obo/INO_0000103	accessory regulation	http://purl.obolibrary.org/obo/INO_0000157	regulation		a positive regulation that one interactor facilitates a phenomenon such as a phenotype. This is an accessory effect not a major one. 
http://purl.obolibrary.org/obo/INO_0000106	gene fusion	http://purl.obolibrary.org/obo/MI_0208	genetic interaction		a genetic interaction that forms a hybrid gene formed from two previously separate genes. It can occur as the result of a translocation, interstitial deletion, or chromosomal inversion.
http://purl.obolibrary.org/obo/INO_0000111	protein heterodimerization	http://purl.obolibrary.org/obo/INO_0000088	protein dimerization		a protein dimerization where two proteins are different. 
http://purl.obolibrary.org/obo/INO_0000112	protein homodimerization	http://purl.obolibrary.org/obo/INO_0000088	protein dimerization		a protein dimerization where two proteins are the same. 
http://purl.obolibrary.org/obo/INO_0000116	immuno-precipitation	http://purl.obolibrary.org/obo/INO_0000176	translocation		a translocation that one interactor is precipitated based on an immunological precipitation process.
http://purl.obolibrary.org/obo/INO_0000118	impairment	http://purl.obolibrary.org/obo/INO_0000068	negative regulation		A negative regulation that disables, damages, or impairs the functioning of another entity.
http://purl.obolibrary.org/obo/INO_0000119	inactivation	http://purl.obolibrary.org/obo/INO_0000068	negative regulation		a negative regulation that one interactor inactivates another.
http://purl.obolibrary.org/obo/INO_0000124	inhibition	http://purl.obolibrary.org/obo/INO_0000068	negative regulation		a negative regulation that one interactor inhibites another.
http://purl.obolibrary.org/obo/INO_0000125	input interactor	http://purl.obolibrary.org/obo/INO_0000016	interactor		an interactor that is an input of an interaction.
http://purl.obolibrary.org/obo/INO_0000126	interference	http://purl.obolibrary.org/obo/INO_0000068	negative regulation		a negative regulation that one interactor interferes a process. 
http://purl.obolibrary.org/obo/INO_0000130	human molecular conversion	http://purl.obolibrary.org/obo/INO_0000023	human molecular interaction		a human molecular interaction where one molecule converts to another molecule.
http://purl.obolibrary.org/obo/INO_0000134	positive regulator role	http://purl.obolibrary.org/obo/INO_0000005	regulator role		an interactor role that is borne by a material entity that positively regulates an interaction.
http://purl.obolibrary.org/obo/INO_0000135	pathway step	http://purl.obolibrary.org/obo/IAO_0000027	data item		An data item that indicates the step number of a pathway.
http://purl.obolibrary.org/obo/INO_0000137	negative regulator role	http://purl.obolibrary.org/obo/INO_0000005	regulator role		an interactor role that is borne by a material entity that negatively regulates an interaction.
http://purl.obolibrary.org/obo/INO_0000140	neutralization	http://purl.obolibrary.org/obo/MI_0407	direct interaction		a biochemical reaction that one interactor neutrolizes another. 
http://purl.obolibrary.org/obo/INO_0000141	positive regulator	http://purl.obolibrary.org/obo/INO_0000008	interaction regulator		an interaction regulator that positively regulates an interaction.
http://purl.obolibrary.org/obo/INO_0000144	negative regulator	http://purl.obolibrary.org/obo/INO_0000008	interaction regulator		an interaction regulator that negatively regulates an interaction.
http://purl.obolibrary.org/obo/INO_0000148	precedence	http://purl.obolibrary.org/obo/MI_0914	association		an indirect association that one interactor is preceded by another interactor. 
http://purl.obolibrary.org/obo/INO_0000151	output interactor	http://purl.obolibrary.org/obo/INO_0000016	interactor		an interactor that is an output of an interaction.
http://purl.obolibrary.org/obo/INO_0000153	reactivation	http://purl.obolibrary.org/obo/INO_0000024	activation		an activation that repeats.
http://purl.obolibrary.org/obo/INO_0000155	recruitment	http://purl.obolibrary.org/obo/INO_0000157	regulation		a positive regulation that leads the recruitment of one interactor from one location to another. 
http://purl.obolibrary.org/obo/INO_0000157	regulation	http://purl.obolibrary.org/obo/MI_0914	association		A regulation represents a regulatory interaction between two interactors. 
http://purl.obolibrary.org/obo/INO_0000165	stabilization	http://purl.obolibrary.org/obo/INO_0000117	positive regulation		a postive interaction that one interactor increases the stability of another interactor. 
http://purl.obolibrary.org/obo/INO_0000169	synergization	http://purl.obolibrary.org/obo/INO_0000089	co-regulation		a regulation process that involves in two interactors that are synergized in affecting a phenomenon (e.g., phenotype).
http://purl.obolibrary.org/obo/INO_0000171	termination	http://purl.obolibrary.org/obo/INO_0000068	negative regulation		a negative regulation that leads to a process termination.
http://purl.obolibrary.org/obo/INO_0000172	transactivation	http://purl.obolibrary.org/obo/INO_0000044	gene expression regulation		a gene expression regulation that leads to an increased rate of gene expression triggered either by biological processes or by artificial means.
http://purl.obolibrary.org/obo/INO_0000173	gene transcription	http://purl.obolibrary.org/obo/INO_0000102	gene expression		an interaction process that creates a complementary RNA copy of a sequence of DNA.
http://purl.obolibrary.org/obo/INO_0000174	genetic transduction	http://purl.obolibrary.org/obo/INO_0000027	cell-cell interaction		a cell-cell interaction that transfers viral, bacterial, or both bacterial and viral DNA from one cell to another using a bacteriophage vector. 
http://purl.obolibrary.org/obo/INO_0000176	translocation	http://purl.obolibrary.org/obo/BFO_0000015	process		A process that changes the location of a material entity.
http://purl.obolibrary.org/obo/INO_0000234	deregulation	http://purl.obolibrary.org/obo/INO_0000068	negative regulation		a negative regulation that results in the deregulation of one interactor on a process. 
http://purl.obolibrary.org/obo/INO_0000235	one-way interaction	http://purl.obolibrary.org/obo/INO_0000002	interaction		A one-way interaction is an interaction that shows one direction between interactors.
http://purl.obolibrary.org/obo/INO_0000241	export	http://purl.obolibrary.org/obo/INO_0000176	translocation		a translocation that one interactor exports from one location
http://purl.obolibrary.org/obo/INO_0000242	import	http://purl.obolibrary.org/obo/INO_0000176	translocation		a translocation that one interactor imports from one location
http://purl.obolibrary.org/obo/INO_0000244	secretion	http://purl.obolibrary.org/obo/INO_0000176	translocation		a translocation that one interactor secretes from the inside of another interactor
http://purl.obolibrary.org/obo/INO_0000311	protein-protein interaction	http://purl.obolibrary.org/obo/INO_0000002	interaction		an interaction between two proteins. 
http://purl.obolibrary.org/obo/INO_0000312	gene-protein interaction	http://purl.obolibrary.org/obo/INO_0000002	interaction		an interaction that involves in a gene DNA and a protein
http://purl.obolibrary.org/obo/IDO_0000405	pathogen role	http://purl.obolibrary.org/obo/BFO_0000023	role		A role borne by pathogen in virtue of the fact that it or one of its products is sufficiently close to an organism towards which it has the pathogenic disposition to allow realization of the pathogenic disposition.
http://purl.obolibrary.org/obo/IDO_0000528	pathogen	http://purl.obolibrary.org/obo/BFO_0000040	material entity		A material entity with a pathogenic disposition.
http://purl.obolibrary.org/obo/INO_0000145	deactivator role	http://purl.obolibrary.org/obo/INO_0000137	negative regulator role		a negative regulator role that is borne by a material entity that deactivates,  inhibits, blocks, or disrupts the action of a biological agent (e.g., enzyme).
http://purl.obolibrary.org/obo/INO_0000147	motivator role	http://purl.obolibrary.org/obo/INO_0000009	input interactor role		an input interactor role that is borne by a material entity that motivates a process.
http://purl.obolibrary.org/obo/INO_0000150	hygiene factor role	http://purl.obolibrary.org/obo/INO_0000009	input interactor role		an input interactor role that is borne by a material entity (e.g. status, job security, salary and fringe benefits) that do not motivate if present, but, if absent, result in demotivation.
http://purl.obolibrary.org/obo/INO_0000158	interaction network model	http://purl.obolibrary.org/obo/IAO_0000030	information content entity		An information content entity that models interaction network
http://purl.obolibrary.org/obo/LifO_0000005	organism	http://purl.obolibrary.org/obo/BFO_0000040	material entity		An organism is an individual entity that exhibits the properties of life, including reproduction, growth and development, maintenance, and response to stimuli. All organisms are composed of one or more cells.
http://purl.obolibrary.org/obo/BFO_0000148	zero-dimensional temporal region	http://purl.obolibrary.org/obo/BFO_0000008	temporal region	temporal instant.	
http://purl.obolibrary.org/obo/INO_0000156	epithelial cell-pathogen protein-protein interaction	http://purl.obolibrary.org/obo/INO_0000152	epithelial cell-pathogen interaction	epithelial cell-pathogen PPI	
http://purl.obolibrary.org/obo/INO_0000090	molecular complex	http://purl.obolibrary.org/obo/CHEBI_23367	molecular entity		
http://purl.obolibrary.org/obo/INO_0000132	small molecule	http://purl.obolibrary.org/obo/CHEBI_23367	molecular entity		
http://purl.obolibrary.org/obo/BFO_0000002	continuant	http://purl.obolibrary.org/obo/BFO_0000001	entity		
http://purl.obolibrary.org/obo/BFO_0000003	occurrent	http://purl.obolibrary.org/obo/BFO_0000001	entity		
http://purl.obolibrary.org/obo/BFO_0000008	temporal region	http://purl.obolibrary.org/obo/BFO_0000003	occurrent		
http://purl.obolibrary.org/obo/BFO_0000141	immaterial entity	http://purl.obolibrary.org/obo/BFO_0000004	independent continuant		
http://purl.obolibrary.org/obo/BFO_0000038	one-dimensional temporal region	http://purl.obolibrary.org/obo/BFO_0000008	temporal region		
http://purl.obolibrary.org/obo/BFO_0000034	function	http://purl.obolibrary.org/obo/BFO_0000016	disposition		
http://purl.obolibrary.org/obo/BFO_0000016	disposition	http://purl.obolibrary.org/obo/BFO_0000017	realizable entity		
http://purl.obolibrary.org/obo/BFO_0000017	realizable entity	http://purl.obolibrary.org/obo/BFO_0000020	specifically dependent continuant		
http://purl.obolibrary.org/obo/BFO_0000019	quality	http://purl.obolibrary.org/obo/BFO_0000020	specifically dependent continuant		
http://purl.obolibrary.org/obo/BFO_0000030	object	http://purl.obolibrary.org/obo/BFO_0000040	material entity		
http://purl.obolibrary.org/obo/BFO_0000029	site	http://purl.obolibrary.org/obo/BFO_0000141	immaterial entity		
http://purl.obolibrary.org/obo/NCBITaxon_1773	Mycobacterium tuberculosis	http://purl.obolibrary.org/obo/NCBITaxon_2	Bacteria		
http://purl.obolibrary.org/obo/NCBITaxon_562	Escherichia coli	http://purl.obolibrary.org/obo/NCBITaxon_2	Bacteria		
http://purl.obolibrary.org/obo/INO_0000115	hyperphosphorylation	http://purl.obolibrary.org/obo/GO_0016310	phosphorylation		
http://purl.obolibrary.org/obo/INO_0000178	tyrosine-phosphorylation	http://purl.obolibrary.org/obo/GO_0016310	phosphorylation		
http://purl.obolibrary.org/obo/NCBITaxon_9606	Homo sapiens	http://purl.obolibrary.org/obo/NCBITaxon_2759	Eukaryota		
http://purl.obolibrary.org/obo/INO_0000092	dissociation	http://purl.obolibrary.org/obo/MI_0407	direct interaction		
http://purl.obolibrary.org/obo/INO_0000142	oxidation	http://purl.obolibrary.org/obo/MI_0414	enzymatic reaction		
http://purl.obolibrary.org/obo/INO_0000041	physical entity - obsolete	http://purl.obolibrary.org/obo/INO_0000159	obsolete class		
http://purl.obolibrary.org/obo/INO_0000121	human molecular synthesis	http://purl.obolibrary.org/obo/INO_0000023	human molecular interaction		
http://purl.obolibrary.org/obo/INO_0000123	human molecular regulatory reaction	http://purl.obolibrary.org/obo/INO_0000023	human molecular interaction		
http://purl.obolibrary.org/obo/INO_0000131	human molecular template reaction	http://purl.obolibrary.org/obo/INO_0000023	human molecular interaction		
http://purl.obolibrary.org/obo/INO_0000066	immunological cross-reaction	http://purl.obolibrary.org/obo/INO_0000054	antigen-antibody interaction		
http://purl.obolibrary.org/obo/INO_0000231	co-expression	http://purl.obolibrary.org/obo/INO_0000061	correlation		
http://purl.obolibrary.org/obo/INO_0000149	prevention	http://purl.obolibrary.org/obo/INO_0000068	negative regulation		
http://purl.obolibrary.org/obo/INO_0000083	human molecular catalysis	http://purl.obolibrary.org/obo/INO_0000101	human molecular control interaction		
http://purl.obolibrary.org/obo/INO_0000127	human molecular modulation	http://purl.obolibrary.org/obo/INO_0000101	human molecular control interaction		
http://purl.obolibrary.org/obo/INO_0000128	human template reaction regulation	http://purl.obolibrary.org/obo/INO_0000101	human molecular control interaction		
http://purl.obolibrary.org/obo/INO_0000110	human molecular degradation	http://purl.obolibrary.org/obo/INO_0000130	human molecular conversion		
http://purl.obolibrary.org/obo/INO_0000117	positive regulation	http://purl.obolibrary.org/obo/INO_0000157	regulation		
http://purl.obolibrary.org/obo/INO_0000062	costimulation	http://purl.obolibrary.org/obo/INO_0000169	synergization		
http://purl.obolibrary.org/obo/NCBITaxon_2157	Archaea	http://purl.obolibrary.org/obo/LifO_0000005	organism		
http://purl.obolibrary.org/obo/NCBITaxon_2	Bacteria	http://purl.obolibrary.org/obo/LifO_0000005	organism		
http://purl.obolibrary.org/obo/NCBITaxon_2759	Eukaryota	http://purl.obolibrary.org/obo/LifO_0000005	organism		
http://purl.obolibrary.org/obo/INO_0000088	protein dimerization				a protein complex assembly that involves two proteins that form a dimer. 
http://purl.obolibrary.org/obo/BFO_0000001	entity				
http://purl.obolibrary.org/obo/INO_0000159	obsolete class				
http://purl.obolibrary.org/obo/BFO_0000051	has part	http://purl.obolibrary.org/obo/RO_0002131	overlaps	has_part	a core relation that holds between a whole and its part
http://purl.obolibrary.org/obo/BFO_0000062	preceded by	http://purl.obolibrary.org/obo/RO_0002086	ends after	preceded_by	x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
http://purl.obolibrary.org/obo/BFO_0000050	part of	http://purl.obolibrary.org/obo/RO_0002131	overlaps	part_of	a core relation that holds between a part and its whole
http://purl.obolibrary.org/obo/RO_0002418	causally upstream of or within	http://purl.obolibrary.org/obo/RO_0002501	causal relation between processes	influences (processual)	p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q.
http://purl.obolibrary.org/obo/RO_0002224	starts with	http://purl.obolibrary.org/obo/RO_0002222	temporally related to	started by	x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
http://purl.obolibrary.org/obo/RO_0002230	ends with	http://purl.obolibrary.org/obo/RO_0002222	temporally related to	finished by	x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
http://purl.obolibrary.org/obo/RO_0002406	directly activates	http://purl.obolibrary.org/obo/RO_0002629	directly positively regulates	directly positively regulates	p directly activates q if and only if p is immediately upstream of q and p is the realization of a function to increase the rate or activity of q
http://purl.obolibrary.org/obo/RO_0002407	indirectly activates	http://purl.obolibrary.org/obo/RO_0002213	positively regulates	indirectly positively regulates	p indirectly activates q if and only if p is upstream of q and there is a chain of directly activates relationships connecting p and q, where the chain is of length greater than one.
http://purl.obolibrary.org/obo/BFO_0000063	precedes	http://purl.obolibrary.org/obo/RO_0002222	temporally related to		x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point.
http://purl.obolibrary.org/obo/RO_0002223	starts	http://purl.obolibrary.org/obo/BFO_0000050	part of		inverse of starts with
http://purl.obolibrary.org/obo/RO_0002404	causally downstream of	http://purl.obolibrary.org/obo/RO_0002427	causally downstream of or within		inverse of upstream of
http://purl.obolibrary.org/obo/RO_0002412	immediately causally upstream of	http://purl.obolibrary.org/obo/RO_0002411	causally upstream of		p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p  must be an input of q.
http://purl.obolibrary.org/obo/RO_0002131	overlaps	http://purl.obolibrary.org/obo/RO_0002323	mereotopologically related to		x overlaps y if and only if there exists some z such that x has part z and z part of y
http://purl.obolibrary.org/obo/RO_0002411	causally upstream of	http://purl.obolibrary.org/obo/RO_0002418	causally upstream of or within		p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain
http://purl.obolibrary.org/obo/RO_0002211	regulates	http://purl.obolibrary.org/obo/RO_0002411	causally upstream of		process(P1) regulates process(P2) iff: P1 results in the initiation or termination of P2 OR affects the frequency of its initiation or termination OR affects the magnitude or rate of output of P2.
http://purl.obolibrary.org/obo/RO_0002212	negatively regulates	http://purl.obolibrary.org/obo/RO_0002211	regulates		Process(P1) negatively regulates process(P2) iff: P1 terminates P2, or P1 descreases the the frequency of initiation of P2 or the magnitude or rate of output of P2.
http://purl.obolibrary.org/obo/RO_0002213	positively regulates	http://purl.obolibrary.org/obo/RO_0002211	regulates		Process(P1) postively regulates process(P2) iff: P1 initiates P2, or P1 increases the the frequency of initiation of P2 or the magnitude or rate of output of P2.
http://purl.obolibrary.org/obo/RO_0002427	causally downstream of or within	http://purl.obolibrary.org/obo/RO_0002501	causal relation between processes		inverse of causally upstream of or within
http://purl.obolibrary.org/obo/RO_0002501	causal relation between processes	http://purl.obolibrary.org/obo/RO_0002410	causally related to		p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q.
http://purl.obolibrary.org/obo/RO_0002229	ends	http://purl.obolibrary.org/obo/BFO_0000050	part of		inverse of ends with
http://purl.obolibrary.org/obo/RO_0002413	directly provides input for	http://purl.obolibrary.org/obo/RO_0002414	transitively provides input for		p1 directly provides input for p2 iff there exists some c such that p1 has_output c and p2 has_input c
http://purl.obolibrary.org/obo/RO_0002414	transitively provides input for	http://purl.obolibrary.org/obo/RO_0002411	causally upstream of		transitive form of directly_provides_input_for
http://purl.obolibrary.org/obo/RO_0002578	directly regulates	http://purl.obolibrary.org/obo/RO_0002211	regulates		Process(P1) directly regulates process(P2) iff: P1 regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  regulates the kinase activity (P2) of protein B then P1 directly regulates P2.
http://purl.obolibrary.org/obo/RO_0002629	directly positively regulates	http://purl.obolibrary.org/obo/RO_0002578	directly regulates		Process(P1) directly postively regulates process(P2) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P1 directly positively regulates P2.
http://purl.obolibrary.org/obo/RO_0002630	directly negatively regulates	http://purl.obolibrary.org/obo/RO_0002578	directly regulates		Process(P1) directly negatively regulates process(P2) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2).  For example, if protein A has protein binding activity(P1) that targets protein B and this binding  negatively regulates the kinase activity (P2) of protein B then P1 directly negatively regulates P2.
http://purl.obolibrary.org/obo/RO_0002081	before or simultaneous with	http://purl.obolibrary.org/obo/RO_0002222	temporally related to	<=	
http://purl.obolibrary.org/obo/RO_0002087	immediately preceded by	http://purl.obolibrary.org/obo/BFO_0000062	preceded by	starts_at_end_of	
http://purl.obolibrary.org/obo/RO_0002090	immediately precedes	http://purl.obolibrary.org/obo/BFO_0000063	precedes	meets	
http://purl.obolibrary.org/obo/RO_0002408	directly inhibits	http://purl.obolibrary.org/obo/RO_0002630	directly negatively regulates	directly negatively regulates	
http://purl.obolibrary.org/obo/RO_0002409	indirectly inhibits	http://purl.obolibrary.org/obo/RO_0002212	negatively regulates	indirectly negatively regulates	
http://purl.obolibrary.org/obo/RO_0002091	starts during	http://purl.obolibrary.org/obo/RO_0002222	temporally related to	io	
http://purl.obolibrary.org/obo/RO_0002092	happens during	http://purl.obolibrary.org/obo/RO_0002091	starts during	during	
http://purl.obolibrary.org/obo/RO_0002093	ends during	http://purl.obolibrary.org/obo/RO_0002222	temporally related to	overlaps	
http://purl.obolibrary.org/obo/RO_0002085	encompasses	http://purl.obolibrary.org/obo/RO_0002088	during which starts	di	
http://purl.obolibrary.org/obo/RO_0002083	before	http://purl.obolibrary.org/obo/RO_0002081	before or simultaneous with		
http://purl.obolibrary.org/obo/RO_0002082	simultaneous with	http://purl.obolibrary.org/obo/RO_0002081	before or simultaneous with		
http://purl.obolibrary.org/obo/RO_0002405	immediately causally downstream of	http://purl.obolibrary.org/obo/RO_0002404	causally downstream of		
http://purl.obolibrary.org/obo/RO_0002089	starts before	http://purl.obolibrary.org/obo/RO_0002222	temporally related to		
http://purl.obolibrary.org/obo/RO_0002086	ends after	http://purl.obolibrary.org/obo/RO_0002222	temporally related to		
http://purl.obolibrary.org/obo/RO_0002084	during which ends	http://purl.obolibrary.org/obo/RO_0002222	temporally related to		
http://purl.obolibrary.org/obo/RO_0002088	during which starts	http://purl.obolibrary.org/obo/RO_0002222	temporally related to		
http://purl.obolibrary.org/obo/RO_0002304	causally upstream of, positive effect	http://purl.obolibrary.org/obo/RO_0004047	causally upstream of or within, positive effect		
http://purl.obolibrary.org/obo/RO_0002305	causally upstream of, negative effect	http://purl.obolibrary.org/obo/RO_0004046	causally upstream of or within, negative effect		
http://purl.obolibrary.org/obo/RO_0004046	causally upstream of or within, negative effect	http://purl.obolibrary.org/obo/RO_0002418	causally upstream of or within		
http://purl.obolibrary.org/obo/RO_0004047	causally upstream of or within, positive effect	http://purl.obolibrary.org/obo/RO_0002418	causally upstream of or within		
http://purl.obolibrary.org/obo/RO_0002234	has output			produces	p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p.
http://purl.obolibrary.org/obo/RO_0000087	has role			has_role	a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence
http://purl.obolibrary.org/obo/RO_0002233	has input			consumes	p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p.
http://purl.obolibrary.org/obo/INO_0000160	has coefficient				An data property that represents the coefficient value in a chemical reaction equation. Specifically, the cofficent is the number in front of a formula in a chemical equation.
http://purl.obolibrary.org/obo/INO_0000154	has interaction type				An object property that represents a relation between an interaction process (domain) and another interaction process (range) where the interaction proces (domain) has a specific type of the other interaction process (range)
http://purl.obolibrary.org/obo/RO_0002323	mereotopologically related to				A mereological relationship or a topological relationship
http://purl.obolibrary.org/obo/INO_0000020	has activator				an object property between an activation process and a material entity that acts as an activator during the process.
http://purl.obolibrary.org/obo/RO_0002410	causally related to				This relation groups causal relations between material entities and causal relations between processes
http://purl.obolibrary.org/obo/BFO_0000054	realized in			realized_in	
http://purl.obolibrary.org/obo/INO_0000139	lacks part				
http://purl.obolibrary.org/obo/RO_0002222	temporally related to				
http://purl.obolibrary.org/obo/INO_0000080	has_controller				
http://purl.obolibrary.org/obo/INO_0000082	controls				
http://purl.obolibrary.org/obo/INO_0000136	has_next_step