Term IRI Term label Parent term IRI Parent term label Alternative term Definition http://purl.obolibrary.org/obo/OAE_0002081 AE occurs in http://purl.obolibrary.org/obo/BFO_0000066 occurs in adverse event occurs in a 'occurs in' relation that is applied at the adverse event setting and indicates where an adverse event occurs in. http://purl.obolibrary.org/obo/RO_0002234 has output http://purl.obolibrary.org/obo/RO_0000057 has_participant produces p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p. http://purl.obolibrary.org/obo/RO_0000052 characteristic of http://purl.obolibrary.org/obo/RO_0002314 characteristic of part of 'inheres in at all times' a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence. http://purl.obolibrary.org/obo/RO_0000079 function of http://purl.obolibrary.org/obo/RO_0000052 characteristic of is function of a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0000085 has function http://purl.obolibrary.org/obo/RO_0000053 bearer of has_function a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0000086 has_quality http://purl.obolibrary.org/obo/RO_0000053 bearer of has_quality a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0002002 has 2D boundary http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to has_2D_boundary a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity http://purl.obolibrary.org/obo/RO_0002087 immediately_preceded_by http://purl.obolibrary.org/obo/BFO_0000062 preceded_by starts_at_end_of X immediately_preceded_by Y iff: end(X) simultaneous_with start(Y) http://purl.obolibrary.org/obo/RO_0002350 member of http://purl.obolibrary.org/obo/BFO_0000050 part of member part of is member of is a mereological relation between a item and a collection. http://purl.obolibrary.org/obo/RO_0002218 has active participant http://purl.obolibrary.org/obo/RO_0000057 has_participant has agent x has participant y if and only if x realizes some active role that inheres in y http://purl.obolibrary.org/obo/BFO_0000051 has part http://purl.obolibrary.org/obo/RO_0002507 has material contribution from has_part Q1 has_part Q2 if and only if: every instance of Q1 is a quality_of an entity that has_quality some Q2. http://purl.obolibrary.org/obo/RO_0000087 has role http://purl.obolibrary.org/obo/RO_0000053 bearer of has_role a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0002150 continuous with http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to connected to X continuous_with Y if and only if X and Y share a fiat boundary. http://purl.obolibrary.org/obo/BFO_0000062 preceded_by http://purl.obolibrary.org/obo/RO_0002086 ends after preceded_by X preceded_by Y iff: end(Y) before_or_simultaneous_with start(X) http://purl.obolibrary.org/obo/RO_0000081 role of http://purl.obolibrary.org/obo/RO_0000052 characteristic of role_of a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/BFO_0000050 part of http://purl.obolibrary.org/obo/RO_0002131 overlaps part_of a core relation that holds between a part and its whole http://purl.obolibrary.org/obo/RO_0002233 has input http://purl.obolibrary.org/obo/RO_0000057 has_participant consumes p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p. http://purl.obolibrary.org/obo/RO_0002215 capable_of http://purl.obolibrary.org/obo/RO_0002216 capable of part of has function realized in A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. http://purl.obolibrary.org/obo/RO_0002376 tributary of http://purl.obolibrary.org/obo/RO_0002375 in branching relationship with tributary channel of x tributary_of y if and only if x a channel for the flow of a substance into y, where y is larger than x. If x and y are hydrographic features, then y is the main stem of a river, or a lake or bay, but not the sea or ocean. If x and y are anatomical, then y is a vein. http://purl.obolibrary.org/obo/RO_0002551 has skeleton http://purl.obolibrary.org/obo/BFO_0000051 has part has supporting framework A relation between a subdivision of an organism and the single subdivision of skeleton that provides structural support for that subdivision. http://purl.obolibrary.org/obo/RO_0002130 has synaptic terminal in http://purl.obolibrary.org/obo/RO_0002131 overlaps has synapse in A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input. http://purl.obolibrary.org/obo/RO_0002216 capable of part of http://purl.obolibrary.org/obo/RO_0002500 causal agent in process has function in c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p. http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within http://purl.obolibrary.org/obo/RO_0002501 causal relation between processes influences (processual) p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q. http://purl.obolibrary.org/obo/RO_0002210 directly develops into http://purl.obolibrary.org/obo/RO_0002203 develops_into developmental precursor of inverse of directly develops from http://purl.obolibrary.org/obo/RO_0002224 starts with http://purl.obolibrary.org/obo/RO_0002222 temporally related to started by x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. http://purl.obolibrary.org/obo/RO_0002230 ends with http://purl.obolibrary.org/obo/RO_0002222 temporally related to finished by x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. http://purl.obolibrary.org/obo/RO_0002231 has start location http://purl.obolibrary.org/obo/RO_0002479 has part that occurs in starts with process that occurs in x 'has starts location' y if and only if there exists some process z such that x 'starts with' z and z 'occurs in' y http://purl.obolibrary.org/obo/RO_0002232 has end location http://purl.obolibrary.org/obo/RO_0002479 has part that occurs in ends with process that occurs in x 'has end location' y if and only if there exists some process z such that x 'ends with' z and z 'occurs in' y http://purl.obolibrary.org/obo/RO_0002256 developmentally induced by http://purl.obolibrary.org/obo/RO_0002258 developmentally preceded by induced by t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor material anatomical entity type T to T', where T' develops_from T http://purl.obolibrary.org/obo/RO_0002285 developmentally replaces http://purl.obolibrary.org/obo/RO_0002258 developmentally preceded by replaces x developmentally replaces y if and only if there is some developmental process that causes x to move or to cease to exist, and for the site that was occupied by x to become occupied by y, where y either comes into existence in this site or moves to this site from somewhere else http://purl.obolibrary.org/obo/RO_0004027 disease has inflammation site http://purl.obolibrary.org/obo/RO_0004026 disease has location A relationship between a disease and an anatomical entity where the disease is triggered by an inflammatory response to stimuli occurring in the anatomical entity http://purl.obolibrary.org/obo/RO_0004028 realized in response to stimulus http://purl.obolibrary.org/obo/RO_0002410 causally related to A relationship between a realizable entity R (e.g. function or disposition) and a material entity M where R is realized in response to a process that has an input stimulus of M. http://purl.obolibrary.org/obo/RO_0004029 disease has feature http://purl.obolibrary.org/obo/RO_0040035 disease relationship A relationship between a disease and some feature of that disease, where the feature is either a phenotype or an isolated disease. http://purl.obolibrary.org/obo/RO_0004030 disease arises from structure http://purl.obolibrary.org/obo/RO_0004019 disease has basis in A relationship between a disease and an anatomical structure where the material basis of the disease is some pathological change in the structure. http://purl.obolibrary.org/obo/RO_0004009 has primary input http://purl.obolibrary.org/obo/RO_0002233 has input p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c. http://purl.obolibrary.org/obo/BFO_0000138 proper part of occurrent http://purl.obolibrary.org/obo/BFO_0000132 part of occurrent b proper_occurrent_part_of c =Def. b occurrent_part_of c & b and c are not identical. (axiom label in BFO2 Reference: [005-001]) http://purl.obolibrary.org/obo/BFO_0000139 temporal part of http://purl.obolibrary.org/obo/BFO_0000132 part of occurrent b temporal_part_of c =Def.b occurrent_part_of c & & for some temporal region t, b occupies_temporal_region t & for all occurrents d, t (if d occupies_temporal_region t & t? occurrent_part_of t then (d occurrent_part_of a iff d occurrent_part_of b)). (axiom label in BFO2 Reference: [078-003]) http://purl.obolibrary.org/obo/BFO_0000158 bearer of at all times http://purl.obolibrary.org/obo/BFO_0000168 has specific dependent at all times b bearer_of c at t =Def. c s-depends_on b at t & b is an independent continuant that is not a spatial region. (axiom label in BFO2 Reference: [053-004]) http://purl.obolibrary.org/obo/BFO_0000186 part of continuant at all times that whole exists http://purl.obolibrary.org/obo/BFO_0000176 part of continuant at some time [copied from inverse property 'has continuant part at all times'] b has_continuant_part c at t = Def. c continuant_part_of b at t. (axiom label in BFO2 Reference: [006-001]) http://purl.obolibrary.org/obo/OAE_0002616 adverse event preceded by http://purl.obolibrary.org/obo/BFO_0000062 preceded_by a specific 'preceded by' object property that has a domain of an adverse event. http://purl.obolibrary.org/obo/RO_0002025 has effector activity http://purl.obolibrary.org/obo/RO_0002017 has component activity A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity. http://purl.obolibrary.org/obo/KTAO_0000007 susceptible to be differentially regulated in AKI in cell http://purl.obolibrary.org/obo/KTAO_0000001 susceptible to be differentially regulated in human disease A shortcut object property that represents a relation between a biological entity and a cell where the entity is susceptible to be differentially regulated in a cell in an acute kidney injury (AKI) patient. http://purl.obolibrary.org/obo/KTAO_0000009 susceptible to be up-regulated in CKD in anatomic location http://purl.obolibrary.org/obo/KTAO_0000008 susceptible to be differentially regulated in CKD in anatomic location A shortcut object property that represents a relation between a biological entity and an anatomic location where the entity is susceptible to be up-regulated in the anatomic location of a chronical kidney disease (CKD) patient. http://purl.obolibrary.org/obo/RO_0040036 results in changes to anatomical or cellular structure http://purl.obolibrary.org/obo/RO_0000057 has_participant p has anatomical participant c iff p has participant c, and c is an anatomical entity http://purl.obolibrary.org/obo/KTAO_0000019 disease has gene biomarker http://purl.obolibrary.org/obo/KTAO_0000018 disease has biomarker An object property that represents a relation between a disease and a gene where the disease has the gene as a biomarker. http://purl.obolibrary.org/obo/KTAO_0000020 disease has protein biomarker http://purl.obolibrary.org/obo/KTAO_0000019 disease has gene biomarker An object property that represents a relation between a disease and a protein where the disease has the protein as a biomarker. http://purl.obolibrary.org/obo/KTAO_0000022 biomarker of disease http://purl.obolibrary.org/obo/KTAO_0000049 biomarker related An object property that represents a relation between a biomarker and a disease where the biomarker serves as a biomarker role for the disease http://purl.obolibrary.org/obo/KTAO_0000023 gene biomarker of disease http://purl.obolibrary.org/obo/KTAO_0000022 biomarker of disease An object property that represents a relation between a gene and a disease where the gene is a biomarkder of the disease. http://purl.obolibrary.org/obo/KTAO_0000025 RNA biomarker of disease http://purl.obolibrary.org/obo/KTAO_0000022 biomarker of disease An object property that represents a relation between a RNA of a gene and a disease where the mRNA expression of the gene is a biomarkder of the disease. http://purl.obolibrary.org/obo/RO_0002100 has soma location http://purl.obolibrary.org/obo/RO_0002131 overlaps Relation between a neuron and a material anatomical entity that its soma is part of. http://purl.obolibrary.org/obo/pato#increased_in_magnitude_relative_to increased_in_magnitude_relative_to http://purl.obolibrary.org/obo/pato#different_in_magnitude_relative_to different_in_magnitude_relative_to q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. http://purl.obolibrary.org/obo/RO_0002160 only in taxon http://purl.obolibrary.org/obo/RO_0002162 in taxon x only in taxon y if and only if x is in taxon y, and there is no other organism z such that y!=z a and x is in taxon z. http://purl.obolibrary.org/obo/RO_0002258 developmentally preceded by http://purl.obolibrary.org/obo/RO_0002324 developmentally related to Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p http://purl.obolibrary.org/obo/RO_0002162 in taxon http://purl.obolibrary.org/obo/RO_0002320 evolutionarily related to x is in taxon y if an only if y is an organism, and the relationship between x and y is one of: part of (reflexive), developmentally preceded by, derives from, secreted by, expressed. http://purl.obolibrary.org/obo/RO_0002286 developmentally succeeded by http://purl.obolibrary.org/obo/RO_0002384 has developmental potential involving Inverse of developmentally preceded by http://purl.obolibrary.org/obo/RO_0002371 attaches_to http://purl.obolibrary.org/obo/RO_0002177 attached to part of a is attached to b if and only if a and b are discrete objects or object parts, and there are physical connections between a and b such that a force pulling a will move b, or a force pulling b will move a http://purl.obolibrary.org/obo/RO_0002384 has developmental potential involving http://purl.obolibrary.org/obo/RO_0002324 developmentally related to x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction). http://purl.obolibrary.org/obo/RO_0002388 has potential to directly develop into http://purl.obolibrary.org/obo/RO_0002387 has potential to develop into x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y http://purl.obolibrary.org/obo/RO_0002178 supplies http://purl.obolibrary.org/obo/RO_0002170 connected to relation between an artery and the structure is supplies with blood. http://purl.obolibrary.org/obo/RO_0002380 branching part of http://purl.obolibrary.org/obo/RO_0002375 in branching relationship with x is a branching part of y if and only if x is part of y and x is connected directly or indirectly to the main stem of y http://purl.obolibrary.org/obo/RO_0002569 has branching part http://purl.obolibrary.org/obo/RO_0002375 in branching relationship with inverse of branching part of http://purl.obolibrary.org/obo/RO_0002571 lumen of http://purl.obolibrary.org/obo/BFO_0000050 part of x lumen_of y iff x is the space or substance that is part of y and does not cross any of the inner membranes or boundaries of y that is maximal with respect to the volume of the convex hull. http://purl.obolibrary.org/obo/uberon/core#anteriorly_connected_to anteriorly connected to http://purl.obolibrary.org/obo/RO_0002170 connected to x anteriorly_connected_to y iff the anterior part of x is connected to y. i.e. x connected_to y and x posterior_to y. http://purl.obolibrary.org/obo/uberon/core#distally_connected_to distally connected to http://purl.obolibrary.org/obo/RO_0002170 connected to x distally_connected_to y iff the distal part of x is connected to y. i.e. x connected_to y and x proximal_to y. http://purl.obolibrary.org/obo/uberon/core#in_central_side_of in_central_side_of http://purl.obolibrary.org/obo/BFO_0000050 part of X in_central_side Y <=> if Y is subdivided into left and right portions around some median divisor, all parts of X are closer to the median divisor than the outermost lateral sides. http://purl.obolibrary.org/obo/uberon/core#posteriorly_connected_to posteriorly connected to http://purl.obolibrary.org/obo/RO_0002170 connected to x posteriorly_connected_to y iff the posterior part of x is connected to y. i.e. x connected_to y and x anterior_to y. http://purl.obolibrary.org/obo/uberon/core#proximally_connected_to proximally connected to http://purl.obolibrary.org/obo/RO_0002170 connected to x proximally_connected_to y iff the proximal part of x is connected to y. i.e. x connected_to y and x distal_to y. http://purl.obolibrary.org/obo/RO_0004020 disease has basis in dysfunction of http://purl.obolibrary.org/obo/RO_0004019 disease has basis in A relation that holds between the disease and a material entity where the physical basis of the disease is a disorder of that material entity that affects its function. http://purl.obolibrary.org/obo/RO_0004021 disease has basis in disruption of http://purl.obolibrary.org/obo/RO_0004019 disease has basis in A relation that holds between the disease and a process where the physical basis of the disease disrupts execution of a key biological process. http://purl.obolibrary.org/obo/RO_0004022 disease has basis in feature http://purl.obolibrary.org/obo/RO_0004019 disease has basis in A relation that holds between the disease and a feature (a phenotype or other disease) where the physical basis of the disease is the feature. http://purl.obolibrary.org/obo/RO_0004024 disease causes disruption of http://purl.obolibrary.org/obo/RO_0004023 causal relationship with disease as subject A relationship between a disease and a process where the disease process disrupts the execution of the process. http://purl.obolibrary.org/obo/RO_0004007 has primary input or output http://purl.obolibrary.org/obo/RO_0000057 has_participant p 'has primary input ot output' c iff either (a) p 'has primary input' c or (b) p 'has primary output' c. http://purl.obolibrary.org/obo/RO_0004008 has primary output http://purl.obolibrary.org/obo/RO_0004007 has primary input or output p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c. http://purl.obolibrary.org/obo/BFO_0000063 precedes http://purl.obolibrary.org/obo/RO_0002222 temporally related to x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. http://purl.obolibrary.org/obo/IAO_0000219 denotes http://purl.obolibrary.org/obo/IAO_0000136 is about A primitive, instance-level, relation obtaining between an information content entity and some portion of reality. Denotation is what happens when someone creates an information content entity E in order to specifically refer to something. The only relation between E and the thing is that E can be used to 'pick out' the thing. This relation connects those two together. Freedictionary.com sense 3: To signify directly; refer to specifically http://purl.obolibrary.org/obo/IAO_0000413 is duration of http://purl.obolibrary.org/obo/IAO_0000136 is about relates a process to a time-measurement-datum that represents the duration of the process http://purl.obolibrary.org/obo/OBI_0000107 provides_service_consumer_with http://purl.obolibrary.org/obo/BFO_0000051 has part A relation between a service and the primary processual part of the service that is performed by the provider for the consumer. http://purl.obolibrary.org/obo/OBI_0000293 has_specified_input http://purl.obolibrary.org/obo/RO_0000057 has_participant The inverse property of is_specified_input_of http://purl.obolibrary.org/obo/OBI_0000295 is_specified_input_of http://purl.obolibrary.org/obo/RO_0000056 participates_in A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of. http://purl.obolibrary.org/obo/OBI_0000299 has_specified_output http://purl.obolibrary.org/obo/RO_0000057 has_participant The inverse property of is_specified_output_of http://purl.obolibrary.org/obo/OBI_0000312 is_specified_output_of http://purl.obolibrary.org/obo/RO_0000056 participates_in A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of. http://purl.obolibrary.org/obo/OBI_0000643 has grain http://purl.obolibrary.org/obo/BFO_0000051 has part the relation of the cells in the finger of the skin to the finger, in which an indeterminate number of grains are parts of the whole by virtue of being grains in a collective that is part of the whole, and in which removing one granular part does not nec- essarily damage or diminish the whole. Ontological Whether there is a fixed, or nearly fixed number of parts - e.g. fingers of the hand, chambers of the heart, or wheels of a car - such that there can be a notion of a single one being missing, or whether, by contrast, the number of parts is indeterminate - e.g., cells in the skin of the hand, red cells in blood, or rubber molecules in the tread of the tire of the wheel of the car. http://purl.obolibrary.org/obo/OBI_0001938 has value specification http://purl.obolibrary.org/obo/BFO_0000051 has part A relation between an information content entity and a value specification that specifies its value. http://purl.obolibrary.org/obo/RO_0002219 surrounded_by http://purl.obolibrary.org/obo/RO_0002220 adjacent_to x surrounded_by y iff: x is adjacent to y and for every region r adjacent to x, r overlaps y http://purl.obolibrary.org/obo/RO_0002220 adjacent_to http://purl.obolibrary.org/obo/RO_0002163 spatially disjoint from x adjacent_to y iff: x and y share a boundary http://purl.obolibrary.org/obo/RO_0002223 starts http://purl.obolibrary.org/obo/BFO_0000050 part of Relation between occurrents, shares a start boundary with. http://purl.obolibrary.org/obo/RO_0002351 has member http://purl.obolibrary.org/obo/BFO_0000051 has part has member is a mereological relation between a collection and an item. http://purl.obolibrary.org/obo/RO_0002018 has component process http://purl.obolibrary.org/obo/RO_0002180 has_component w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type. http://purl.obolibrary.org/obo/RO_0002202 develops_from http://purl.obolibrary.org/obo/RO_0002507 has material contribution from x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y http://purl.obolibrary.org/obo/RO_0002451 transmitted by http://purl.obolibrary.org/obo/RO_0002321 ecologically related to A relationship that holds between a disease and organism http://purl.obolibrary.org/obo/OGG_0000000014 is genome of organism http://purl.obolibrary.org/obo/BFO_0000176 part of continuant at some time a 'part of continuant at some time' relation that incides a genome belongs to a organism. http://purl.obolibrary.org/obo/OGG_0000000016 is gene of organism http://purl.obolibrary.org/obo/BFO_0000176 part of continuant at some time a relation between a gene and the organism where this gene belongs to the organism in nature. It does not include a foreign gene that is transferred to an organism by a genetic engineering method. http://purl.obolibrary.org/obo/RO_0002309 has exposure stimulus http://purl.obolibrary.org/obo/RO_0002244 related via exposure to A relationship between an exposure event or process and any agent, stimulus, activity, or event that causally effects an organism and interacts with an exposure receptor during an exposure event. http://purl.obolibrary.org/obo/RO_0002176 connects http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to Binary relationship: z connects x if and only if there exists some y such that z connects x and y in a ternary connected_to(x,y,z) relationship. http://purl.obolibrary.org/obo/RO_0002491 existence starts and ends during http://purl.obolibrary.org/obo/RO_0002492 existence ends during x exists during y if and only if: 1) the time point at which x begins to exist is after or equal to the time point at which y begins and 2) the time point at which x ceases to exist is before or equal to the point at which y ends. Formally: x existence starts and ends during y iff α(x) >= α(y) & α(x) <= ω(y) & ω(x) <= ω(y) & ω(x) >= α(y) http://purl.obolibrary.org/obo/RO_0002333 enabled by http://purl.obolibrary.org/obo/RO_0002328 functionally related to inverse of enables http://purl.obolibrary.org/obo/RO_0002412 immediately causally upstream of http://purl.obolibrary.org/obo/RO_0002411 causally upstream of p is immediately causally upstream of q iff p is causally upstream of q, and the end of p is coincident with the beginning of q. http://purl.obolibrary.org/obo/RO_0002566 causally influences http://purl.obolibrary.org/obo/RO_0002506 causal relation between material entities Holds between materal entities a and b if the activity of a is causally upstream of the activity of b, or causally upstream of a an activity that modifies b http://purl.obolibrary.org/obo/BFO_0000187 has continuant part at all times that part exists http://purl.obolibrary.org/obo/BFO_0000178 has continuant part at some time forall(t) exists_at(y,t) -> exists_at(x,t) and 'has continuant part'(x,y,t) http://purl.obolibrary.org/obo/RO_0002490 existence overlaps http://purl.obolibrary.org/obo/RO_0002487 relation between physical entity and a process or stage x existence overlaps y if and only if either (a) the start of x is part of y or (b) the end of x is part of y. Formally: x existence starts and ends during y iff (α(x) >= α(y) & α(x) <= ω(y)) OR (ω(x) <= ω(y) & ω(x) >= α(y)) http://purl.obolibrary.org/obo/RO_0002244 related via exposure to http://purl.obolibrary.org/obo/RO_0002410 causally related to Any relationship between an exposure event or process and any other entity. http://purl.obolibrary.org/obo/RO_0002252 connecting branch of http://purl.obolibrary.org/obo/RO_0002375 in branching relationship with b connecting-branch-of s iff b is connected to s, and there exists some tree-like structure t such that the mereological sum of b plus s is either the same as t or a branching-part-of t. http://purl.obolibrary.org/obo/RO_0002253 has connecting branch http://purl.obolibrary.org/obo/RO_0002375 in branching relationship with inverse of connecting branch of http://purl.obolibrary.org/obo/RO_0002304 causally upstream of, positive effect http://purl.obolibrary.org/obo/RO_0004047 causally upstream of or within, positive effect p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q. http://purl.obolibrary.org/obo/RO_0002305 causally upstream of, negative effect http://purl.obolibrary.org/obo/RO_0004046 causally upstream of or within, negative effect p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q. http://purl.obolibrary.org/obo/RO_0002131 overlaps http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to A overlaps B if they share some part in common. http://purl.obolibrary.org/obo/RO_0002254 has developmental contribution from http://purl.obolibrary.org/obo/RO_0002507 has material contribution from x has developmental contribution from y iff x has some part z such that z develops from y http://purl.obolibrary.org/obo/RO_0002496 existence starts during or after http://purl.obolibrary.org/obo/RO_0002487 relation between physical entity and a process or stage x existence starts during or after y if and only if the time point at which x starts is after or equivalent to the time point at which y starts. Formally: x existence starts during or after y iff α (x) >= α (y). http://purl.obolibrary.org/obo/RO_0002497 existence ends during or before http://purl.obolibrary.org/obo/RO_0002487 relation between physical entity and a process or stage x existence ends during or before y if and only if the time point at which x ends is before or equivalent to the time point at which y ends. http://purl.obolibrary.org/obo/BFO_0000052 inheres in at all times http://purl.obolibrary.org/obo/BFO_0000070 specifically depends on at all times b inheres_in c at t =Def. b is a dependent continuant & c is an independent continuant that is not a spatial region & b s-depends_on c at t. (axiom label in BFO2 Reference: [051-002]) http://purl.obolibrary.org/obo/RO_0000091 has disposition http://purl.obolibrary.org/obo/RO_0000053 bearer of a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/BSPO_0000120 in left side of http://purl.obolibrary.org/obo/BSPO_0000126 in lateral side of X in_left_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the left portion. http://purl.obolibrary.org/obo/BSPO_0000121 in right side of http://purl.obolibrary.org/obo/BSPO_0000126 in lateral side of X in_right_side_of Y <=> if Y is subdivided into left and right portions, X is part_of the right portion. http://purl.obolibrary.org/obo/BSPO_0000122 in_posterior_side_of http://purl.obolibrary.org/obo/BFO_0000050 part of X posterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the posterior portion. http://purl.obolibrary.org/obo/BSPO_0000123 in_anterior_side_of http://purl.obolibrary.org/obo/BFO_0000050 part of X anterior_side_of Y <=> if Y is subdivided into two anterior and posterior portions, X is part_of the anterior portion. http://purl.obolibrary.org/obo/BSPO_0000124 in_proximal_side_of http://purl.obolibrary.org/obo/BFO_0000050 part of X proximal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the proximal portion. http://purl.obolibrary.org/obo/BSPO_0000125 in_distal_side_of http://purl.obolibrary.org/obo/BFO_0000050 part of X distal_side_of Y <=> if Y is subdivided into distal and proximal portions, X is part_of the distal portion. http://purl.obolibrary.org/obo/BSPO_0000126 in lateral side of http://purl.obolibrary.org/obo/BFO_0000050 part of X in_lateral_side_of Y <=> if X is in_left_side_of Y or X is in_right_side_of Y. X is often, but not always a paired structure http://purl.obolibrary.org/obo/BSPO_0001106 proximalmost part of http://purl.obolibrary.org/obo/BSPO_0000124 in_proximal_side_of X proximalmost_part_of Y <=> X is part_of Y and X is adjacent_to the proximal boundary of Y http://purl.obolibrary.org/obo/BSPO_0001107 immediately_deep_to http://purl.obolibrary.org/obo/BSPO_0000107 deep_to This relation holds when both the deep_to and ajdacent_to relationship similarly hold. http://purl.obolibrary.org/obo/BSPO_0001108 distalmost part of http://purl.obolibrary.org/obo/BSPO_0000125 in_distal_side_of X distalmost_part_of Y <=> X is part_of Y and X is adjacent_to the distal boundary of Y http://purl.obolibrary.org/obo/RO_0012003 acts on population of http://purl.obolibrary.org/obo/RO_0000057 has_participant p acts on population of c iff c' is a collection, has members of type c, and p has participant c http://purl.obolibrary.org/obo/RO_0013001 has synaptic IO in region http://purl.obolibrary.org/obo/RO_0002130 has synaptic terminal in A relationship between a neuron and a region, where the neuron has a functionally relevant number of input and/or output synapses in that region. http://purl.obolibrary.org/obo/RO_0002411 causally upstream of http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q. http://purl.obolibrary.org/obo/RO_0002211 has_component http://purl.obolibrary.org/obo/RO_0002411 causally upstream of p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q. http://purl.obolibrary.org/obo/RO_0002212 negatively regulates http://purl.obolibrary.org/obo/RO_0002211 has_component p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q. http://purl.obolibrary.org/obo/RO_0002213 positively regulates http://purl.obolibrary.org/obo/RO_0002211 has_component p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q. http://purl.obolibrary.org/obo/pr#has_gene_template has_gene_template http://purl.obolibrary.org/obo/RO_0002330 genomically related to See document https://docs.google.com/document/d/15iVMtMyYbQSlvUDgn2XUaDzpwkB0USZI for full definition. http://purl.obolibrary.org/obo/RO_0002180 has_component http://purl.obolibrary.org/obo/BFO_0000051 has part w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type. http://purl.obolibrary.org/obo/RO_0002163 spatially disjoint from http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to A is spatially_disjoint_from B if and only if they have no parts in common http://purl.obolibrary.org/obo/RO_0002314 characteristic of part of http://purl.obolibrary.org/obo/RO_0002502 depends on q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w. http://purl.obolibrary.org/obo/RO_0002352 input of http://purl.obolibrary.org/obo/RO_0002328 functionally related to inverse of has input http://purl.obolibrary.org/obo/RO_0002353 output_of http://purl.obolibrary.org/obo/RO_0002328 functionally related to inverse of has output http://purl.obolibrary.org/obo/RO_0002473 composed primarily of http://purl.obolibrary.org/obo/BFO_0000051 has part x composed_primarily_of y iff: more than half of the mass of x is made from parts of y http://purl.obolibrary.org/obo/cl#has_high_plasma_membrane_amount has_high_plasma_membrane_amount http://purl.obolibrary.org/obo/RO_0002104 has plasma membrane part A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617). http://purl.obolibrary.org/obo/cl#has_low_plasma_membrane_amount has_low_plasma_membrane_amount http://purl.obolibrary.org/obo/RO_0002104 has plasma membrane part A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface. For the formal definition, see Masci et al (PMID:19243617). http://purl.obolibrary.org/obo/RO_0002104 has plasma membrane part http://purl.obolibrary.org/obo/BFO_0000051 has part Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part. http://purl.obolibrary.org/obo/RO_0002203 develops_into http://purl.obolibrary.org/obo/RO_0002387 has potential to develop into inverse of develops from http://purl.obolibrary.org/obo/RO_0002387 has potential to develop into http://purl.obolibrary.org/obo/RO_0002384 has developmental potential involving x has the potential to develop into y iff x develops into y or if x is capable of developing into y http://purl.obolibrary.org/obo/RO_0002021 occurs across http://purl.obolibrary.org/obo/RO_0002479 has part that occurs in A relationship between a process and a barrier, where the process occurs in a region spanning the barrier. For cellular processes the barrier is typically a membrane. Examples include transport across a membrane and membrane depolarization. http://purl.obolibrary.org/obo/KTAO_0000016 is gene marker of cell http://purl.obolibrary.org/obo/KTAO_0000050 is biomarker of cell An object property that represents a relation between a gene and a cell type where the gene is the gene marker of the cell type http://purl.obolibrary.org/obo/KTAO_0000017 cell has gene marker http://purl.obolibrary.org/obo/KTAO_0000049 biomarker related An object property that represents a relation between a celltype and a gene where the cell has the gene as its gene marker http://purl.obolibrary.org/obo/RO_0015007 increased in magnitude relative to http://purl.obolibrary.org/obo/RO_0015006 different in magnitude relative to q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. http://purl.obolibrary.org/obo/BFO_0000162 has disposition at all times http://purl.obolibrary.org/obo/BFO_0000158 bearer of at all times a has_disposition b at t =Def. b disposition_of a at t. (axiom label in BFO2 Reference: [069-001]) http://purl.obolibrary.org/obo/RO_0015008 decreased in magnitude relative to http://purl.obolibrary.org/obo/RO_0015006 different in magnitude relative to q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. http://purl.obolibrary.org/obo/RO_0002007 bounding layer of http://purl.obolibrary.org/obo/BFO_0000050 part of X outer_layer_of Y iff: . X :continuant that bearer_of some PATO:laminar . X part_of Y . exists Z :surface . X has_boundary Z . Z boundary_of Y has_boundary: http://purl.obolibrary.org/obo/RO_0002002 boundary_of: http://purl.obolibrary.org/obo/RO_0002000 http://purl.obolibrary.org/obo/RO_0002170 connected to http://purl.obolibrary.org/obo/uberon/core#transitively_connected_to transitively_connected to Binary relationship: x connected_to y if and only if there exists some z such that z connects x and y in a ternary connected_to(x,y,z) relationship. http://purl.obolibrary.org/obo/RO_0002177 attached to part of http://purl.obolibrary.org/obo/RO_0002567 biomechanically related to a is attached to part of b if a is attached to b, or a is attached to some p, where p is part of b. http://purl.obolibrary.org/obo/RO_0002179 drains http://purl.obolibrary.org/obo/RO_0002170 connected to Relation between an collecting structure and another structure, where the collecting structure acts as a conduit channeling fluid, substance or energy away from the other structure. http://purl.obolibrary.org/obo/RO_0002375 in branching relationship with http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to A relationship that holds between two material entities in a system of connected structures, where the branching relationship holds based on properties of the connecting network. http://purl.obolibrary.org/obo/RO_0002503 towards http://purl.obolibrary.org/obo/RO_0002502 depends on q towards e2 if and only if q is a relational quality such that q inheres-in some e, and e != e2 and q is dependent on e2 http://purl.obolibrary.org/obo/RO_0002567 biomechanically related to http://purl.obolibrary.org/obo/RO_0002328 functionally related to A relation that holds between elements of a musculoskeletal system or its analogs. http://purl.obolibrary.org/obo/RO_0002433 contributes to morphology of http://purl.obolibrary.org/obo/RO_0002131 overlaps p contributes to morphology of w if and only if a change in the morphology of p entails a change in the morphology of w. Examples: every skull contributes to morphology of the head which it is a part of. Counter-example: nuclei do not generally contribute to the morphology of the cell they are part of, as they are buffered by cytoplasm. http://purl.obolibrary.org/obo/RO_0002488 existence starts during http://purl.obolibrary.org/obo/RO_0002496 existence starts during or after Relation between continuant c and occurrent s, such that every instance of c comes into existing during some s. http://purl.obolibrary.org/obo/RO_0002489 existence starts with http://purl.obolibrary.org/obo/RO_0002488 existence starts during Relation between continuant and occurrent, such that c comes into existence at the start of p. http://purl.obolibrary.org/obo/RO_0002492 existence ends during http://purl.obolibrary.org/obo/RO_0002497 existence ends during or before Relation between continuant c and occurrent s, such that every instance of c ceases to exist during some s, if it does not die prematurely. http://purl.obolibrary.org/obo/RO_0002493 existence ends with http://purl.obolibrary.org/obo/RO_0002492 existence ends during Relation between continuant and occurrent, such that c ceases to exist at the end of p. http://purl.obolibrary.org/obo/RO_0002494 transformation of http://purl.obolibrary.org/obo/RO_0002202 develops_from x transformation of y if x is the immediate transformation of y, or is linked to y through a chain of transformation relationships http://purl.obolibrary.org/obo/RO_0002495 immediate transformation of http://purl.obolibrary.org/obo/RO_0002207 directly develops from x immediate transformation of y iff x immediately succeeds y temporally at a time boundary t, and all of the matter present in x at t is present in y at t, and all the matter in y at t is present in x at t http://purl.obolibrary.org/obo/RO_0002507 has material contribution from http://purl.obolibrary.org/obo/RO_0002559 causally influenced by s determined by f if and only if s is a type of system, and f is a material entity that is part of s, such that f exerts a strong causal influence on the functioning of s, and the removal of f would cause the collapse of s. http://purl.obolibrary.org/obo/RO_0002572 luminal space of http://purl.obolibrary.org/obo/BFO_0000050 part of s is luminal space of x iff s is lumen_of x and s is an immaterial entity http://purl.obolibrary.org/obo/RO_0002576 skeleton of http://purl.obolibrary.org/obo/BFO_0000050 part of inverse of has skeleton http://purl.obolibrary.org/obo/uberon/core#extends_fibers_into extends_fibers_into http://purl.obolibrary.org/obo/RO_0002170 connected to X extends_fibers into Y iff there exists some neuron (N) and N has_soma_location X and N 'has synaptic IO in region' some Y http://purl.obolibrary.org/obo/KTAO_0000003 susceptible to be up-regulated in CKD in cell http://purl.obolibrary.org/obo/KTAO_0000002 susceptible to be differentially regulated in CKD in cell A shortcut object property that represents a relation between a biological entity and a cell where the entity is susceptible to be up-regulated in a cell of a chronical kidney disease (CKD) patient http://purl.obolibrary.org/obo/KTAO_0000004 susceptible to be down-regulated in CKD in cell http://purl.obolibrary.org/obo/KTAO_0000002 susceptible to be differentially regulated in CKD in cell A shortcut object property that represents a relation between a biological entity and a cell where the entity is susceptible to be down-regulated in a cell of a chronical kidney disease (CKD) patient http://purl.obolibrary.org/obo/OPMI_0000171 has question http://purl.obolibrary.org/obo/BFO_0000051 has part A 'has part' object property that has the range of a textual question http://purl.obolibrary.org/obo/pr#has_constituent_monomer has_constituent_monomer http://purl.obolibrary.org/obo/RO_0002180 has_component A relation that holds between a polymer and its constituent monomers. P has_constituent_monomer c if and only if P has_component multiple instances of c and each instance of c is covalently attached to another instance of c. http://purl.obolibrary.org/obo/BFO_0000118 has proper occurrent part http://purl.obolibrary.org/obo/BFO_0000117 has occurrent part b has_proper_occurrent_part c = Def. c proper_occurrent_part_of b. [XXX-001 http://purl.obolibrary.org/obo/RO_0002255 developmentally_contributes_to http://purl.obolibrary.org/obo/RO_0002385 has potential to developmentally contribute to inverse of has developmental contribution from http://purl.obolibrary.org/obo/RO_0002334 regulated by http://purl.obolibrary.org/obo/RO_0002427 causally downstream of or within inverse of regulates http://purl.obolibrary.org/obo/RO_0002335 negatively regulated by http://purl.obolibrary.org/obo/RO_0002334 regulated by inverse of negatively regulates http://purl.obolibrary.org/obo/RO_0002336 positively regulated by http://purl.obolibrary.org/obo/RO_0002334 regulated by inverse of positively regulates http://purl.obolibrary.org/obo/RO_0002385 has potential to developmentally contribute to http://purl.obolibrary.org/obo/RO_0002384 has developmental potential involving x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y http://purl.obolibrary.org/obo/RO_0002410 causally related to http://purl.obolibrary.org/obo/RO_0002609 related via dependence to relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause. http://purl.obolibrary.org/obo/RO_0002427 causally downstream of or within http://purl.obolibrary.org/obo/RO_0002501 causal relation between processes inverse of causally upstream of or within http://purl.obolibrary.org/obo/RO_0002500 causal agent in process http://purl.obolibrary.org/obo/RO_0002595 causal relation between material entity and a process A relationship between a material entity and a process where the material entity has some causal role that influences the process http://purl.obolibrary.org/obo/RO_0002501 causal relation between processes http://purl.obolibrary.org/obo/RO_0002410 causally related to p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q. http://purl.obolibrary.org/obo/RO_0002595 causal relation between material entity and a process http://purl.obolibrary.org/obo/RO_0002410 causally related to A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity. http://purl.obolibrary.org/obo/RO_0002608 process has causal agent http://purl.obolibrary.org/obo/RO_0002410 causally related to Inverse of 'causal agent in process' http://purl.obolibrary.org/obo/KTAO_0000010 susceptible to be down-regulated in CKD in anatomic location http://purl.obolibrary.org/obo/KTAO_0000008 susceptible to be differentially regulated in CKD in anatomic location A shortcut object property that represents a relation between a biological entity and an anatomic location where the entity is susceptible to be down-regulated in the anatomic location of a chronical kidney disease (CKD) patient. http://purl.obolibrary.org/obo/KTAO_0000012 susceptible to be up-regulated in AKI in cell http://purl.obolibrary.org/obo/KTAO_0000007 susceptible to be differentially regulated in AKI in cell A shortcut object property that represents a relation between a biological entity and a cell where the entity is susceptible to be up-regulated in a cell of an acute kidney injury (AKI) patient http://purl.obolibrary.org/obo/KTAO_0000013 susceptible to be down-regulated in AKI in cell http://purl.obolibrary.org/obo/KTAO_0000007 susceptible to be differentially regulated in AKI in cell A shortcut object property that represents a relation between a biological entity and a cell where the entity is susceptible to be down-regulated in a cell of an acute kidney injury (AKI) patient http://purl.obolibrary.org/obo/KTAO_0000014 susceptible to be down-regulated in AKI in anatomic location http://purl.obolibrary.org/obo/KTAO_0000011 susceptible to be differentially regulated in AKI in anatomic location A shortcut object property that represents a relation between a biological entity and an anatomic location where the entity is susceptible to be down-regulated in the anatomic location of an acute kidney injury (AKI) patient. http://purl.obolibrary.org/obo/KTAO_0000015 susceptible to be up-regulated in AKI in anatomic location http://purl.obolibrary.org/obo/KTAO_0000011 susceptible to be differentially regulated in AKI in anatomic location A shortcut object property that represents a relation between a biological entity and an anatomic location where the entity is susceptible to be down-regulated in the anatomic location of an acute kidney injury (AKI) patient. http://purl.obolibrary.org/obo/OPMI_0000438 has increased susceptibility compared to male to http://purl.obolibrary.org/obo/OPMI_0000424 has sex-specific susceptibility to An object property that represents a relation between a person with a biological sex and a process where the person has an increased susceptbility to a process compared to corresponding male population http://purl.obolibrary.org/obo/OPMI_0000439 has increased susceptibility compared to female to http://purl.obolibrary.org/obo/OPMI_0000424 has sex-specific susceptibility to An object property that represents a relation between a person with a biological sex and a process where the person has an increased susceptbility to a process compared to corresponding female population http://purl.obolibrary.org/obo/OPMI_0000440 has increased sex-specific susceptibility compared to sex baseline to http://purl.obolibrary.org/obo/OPMI_0000424 has sex-specific susceptibility to An object property that represents a relation between a person with a biological sex and a process where the person has an increased susceptbility to a process compared to the whole population with all sexes included http://purl.obolibrary.org/obo/KTAO_0000024 protein biomarker of disease http://purl.obolibrary.org/obo/KTAO_0000022 biomarker of disease An object property that represents a relation between a protein and a disease where the protein is a biomarkder of the disease. http://purl.obolibrary.org/obo/RO_0002082 simultaneous_with http://purl.obolibrary.org/obo/RO_0002229 ends x simultaneous with y iff ω(x) = ω(y) and ω(α ) = ω(α), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point and '=' indicates the same instance in time. http://purl.obolibrary.org/obo/RO_0002206 expressed in http://purl.obolibrary.org/obo/RO_0002330 genomically related to x expressed in y if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and the transcription of x is part of the gene expression process (iii) x is a mature gene product such as a protein, and x was translated or otherwise processes from a transcript that was transcribed as part of this gene expression process http://purl.obolibrary.org/obo/RO_0002207 directly develops from http://purl.obolibrary.org/obo/RO_0002202 develops_from Candidate definition: x directly_develops from y if and only if there exists some developmental process (GO:0032502) p such that x and y both participate in p, and x is the output of p and y is the input of p, and a substantial portion of the matter of x comes from y, and the start of x is coincident with or after the end of y. http://purl.obolibrary.org/obo/RO_0002221 surrounds http://purl.obolibrary.org/obo/RO_0002220 adjacent_to inverse of surrounded_by http://purl.obolibrary.org/obo/RO_0002225 develops from part of http://purl.obolibrary.org/obo/RO_0002202 develops_from x develops from part of y if and only if there exists some z such that x develops from z and z is part of y http://purl.obolibrary.org/obo/RO_0002229 ends http://purl.obolibrary.org/obo/BFO_0000050 part of Relation between occurrents, shares an end boundary with. http://purl.obolibrary.org/obo/RO_0002257 developmentally induces http://purl.obolibrary.org/obo/RO_0002386 has potential to developmentally induce Inverse of developmentally induced by http://purl.obolibrary.org/obo/RO_0002292 expresses http://purl.obolibrary.org/obo/RO_0002330 genomically related to y expresses x if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and x was transcribed from a gene as part of the gene expression process (iii) x is a mature gene product (protein or RNA), and x was translated or otherwise processed from a transcript that was transcribed as part of the gene expression process. http://purl.obolibrary.org/obo/RO_0002295 results in developmental progression of http://purl.obolibrary.org/obo/RO_0002324 developmentally related to p results in the developmental progression of s iff p is a developmental process and s is an anatomical entity and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss). http://purl.obolibrary.org/obo/RO_0002296 results in development of http://purl.obolibrary.org/obo/RO_0002295 results in developmental progression of p 'results in development of' c if and only if p is a developmental process and p results in the state of c changing from its initial state as a primordium or anlage through its mature state and to its final state. http://purl.obolibrary.org/obo/RO_0002298 results in morphogenesis of http://purl.obolibrary.org/obo/RO_0002295 results in developmental progression of The relationship that links an entity with the process that results in the formation and shaping of that entity over time from an immature to a mature state. http://purl.obolibrary.org/obo/RO_0009501 realized in response to http://purl.obolibrary.org/obo/RO_0002410 causally related to r 'realized in response to' s iff, r is a realizable (e.g. a plant trait such as responsivity to drought), s is an environmental stimulus (a process), and s directly causes the realization of r. http://purl.obolibrary.org/obo/RO_0004026 disease has location http://purl.obolibrary.org/obo/RO_0040035 disease relationship A relationship between a disease and an anatomical entity where the disease has one or more features that are located in that entity. http://purl.obolibrary.org/obo/OPMI_0000301 has exclusion question http://purl.obolibrary.org/obo/OPMI_0000171 has question An object property that represents a relation between a form and a question where the question sets up an exclusion criterion. Specifically, when the answer to the question is Yes, the candidate becomes ineligible for the participation of a study. http://purl.obolibrary.org/obo/OPMI_0000305 has inclusion question http://purl.obolibrary.org/obo/OPMI_0000171 has question An object property that represents a relation between a form and a question where the question sets up an inclusion criterion. Specifically, when the answer to the question is Yes, then the candidate fulfills a criterion for being eligible for participating in a study. Note that there might be other criteria that the candidate also need to meet in order to be fully eligible. Meanwhile, if the answer is No, the candidate may still be eligible depending on the other restriction. http://purl.obolibrary.org/obo/RO_0015015 has high plasma membrane amount http://purl.obolibrary.org/obo/RO_0002104 has plasma membrane part A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface. http://purl.obolibrary.org/obo/RO_0015016 has low plasma membrane amount http://purl.obolibrary.org/obo/RO_0002104 has plasma membrane part A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface. http://purl.obolibrary.org/obo/RO_0002315 results in acquisition of features of http://purl.obolibrary.org/obo/RO_0002295 results in developmental progression of The relationship that links a specified entity with the process that results in an unspecified entity acquiring the features and characteristics of the specified entity http://purl.obolibrary.org/obo/RO_0002332 regulates levels of http://purl.obolibrary.org/obo/RO_0002328 functionally related to p regulates levels of c if p regulates some amount (PATO:0000070) of c http://purl.obolibrary.org/obo/RO_0002338 has target start location http://purl.obolibrary.org/obo/RO_0002344 results in transport to from or in This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from some initial location l to some destination. http://purl.obolibrary.org/obo/RO_0002339 has target end location http://purl.obolibrary.org/obo/RO_0002344 results in transport to from or in This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from a an initial location to some destination l. http://purl.obolibrary.org/obo/RO_0002341 results in transport along http://purl.obolibrary.org/obo/RO_0002337 related via localization to Holds between p and l when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that is aligned_with l http://purl.obolibrary.org/obo/RO_0002342 results in transport across http://purl.obolibrary.org/obo/RO_0002344 results in transport to from or in Holds between p and m when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that crosses m. http://purl.obolibrary.org/obo/RO_0002386 has potential to developmentally induce http://purl.obolibrary.org/obo/RO_0002384 has developmental potential involving x has potential to developmentally induce y iff x developmentally induces y or x is capable of developmentally inducing y http://purl.obolibrary.org/obo/RO_0002508 determines http://purl.obolibrary.org/obo/RO_0002566 causally influences inverse of determined by http://purl.obolibrary.org/obo/RO_0002509 determined by part of http://purl.obolibrary.org/obo/RO_0002131 overlaps s 'determined by part of' w if and only if there exists some f such that (1) s 'determined by' f and (2) f part_of w, or f=w. http://purl.obolibrary.org/obo/RO_0002565 results in movement of http://purl.obolibrary.org/obo/RO_0040036 results in changes to anatomical or cellular structure Holds between p and c when p is locomotion process and the outcome of this process is the change of location of c http://purl.obolibrary.org/obo/RO_0002570 conduit for http://purl.obolibrary.org/obo/RO_0002131 overlaps x is a conduit for y iff y overlaps through the lumen_of of x, and y has parts on either side of the lumen of x. http://purl.obolibrary.org/obo/RO_0002578 directly regulates http://purl.obolibrary.org/obo/RO_0002211 has_component p directly regulates q iff p is immediately causally upstream of q and p regulates q. http://purl.obolibrary.org/obo/RO_0002586 results in breakdown of http://purl.obolibrary.org/obo/RO_0002233 has input p results in breakdown of c if and only if the execution of p leads to c no longer being present at the end of p http://purl.obolibrary.org/obo/RO_0002592 results in organization of http://purl.obolibrary.org/obo/RO_0000057 has_participant p results in organization of c iff p results in the assembly, arrangement of constituent parts, or disassembly of c http://purl.obolibrary.org/obo/RO_0002081 before or simultaneous with http://purl.obolibrary.org/obo/RO_0002222 temporally related to <= http://purl.obolibrary.org/obo/RO_0002090 immediately precedes http://purl.obolibrary.org/obo/BFO_0000063 precedes meets http://purl.obolibrary.org/obo/RO_0002327 enables http://purl.obolibrary.org/obo/RO_0002215 capable_of is executing http://purl.obolibrary.org/obo/RO_0002091 starts during http://purl.obolibrary.org/obo/RO_0002222 temporally related to io http://purl.obolibrary.org/obo/RO_0002092 happens during http://purl.obolibrary.org/obo/RO_0002093 ends_during during http://purl.obolibrary.org/obo/RO_0002093 ends_during http://purl.obolibrary.org/obo/RO_0002222 temporally related to overlaps http://purl.obolibrary.org/obo/mondo#disease_has_major_feature disease has major feature http://purl.obolibrary.org/obo/RO_0004029 disease has feature http://purl.obolibrary.org/obo/KTAO_0000021 disease has RNA biomarker http://purl.obolibrary.org/obo/KTAO_0000019 disease has gene biomarker http://purl.obolibrary.org/obo/KTAO_0000018 disease has biomarker http://purl.obolibrary.org/obo/KTAO_0000049 biomarker related http://purl.obolibrary.org/obo/KTAO_0000050 is biomarker of cell http://purl.obolibrary.org/obo/KTAO_0000049 biomarker related http://purl.obolibrary.org/obo/RO_0002297 results in formation of http://purl.obolibrary.org/obo/RO_0002295 results in developmental progression of http://purl.obolibrary.org/obo/GOREL_0002004 results in fission of http://purl.obolibrary.org/obo/RO_0000057 has_participant http://purl.obolibrary.org/obo/RO_0002017 has component activity http://purl.obolibrary.org/obo/RO_0002018 has component process http://purl.obolibrary.org/obo/IAO_0000039 has measurement unit label http://purl.obolibrary.org/obo/BFO_0000051 has part http://purl.obolibrary.org/obo/RO_0002559 causally influenced by http://purl.obolibrary.org/obo/RO_0002506 causal relation between material entities http://purl.obolibrary.org/obo/so#member_of member_of http://purl.obolibrary.org/obo/so#part_of part_of http://purl.obolibrary.org/obo/BFO_0000168 has specific dependent at all times http://purl.obolibrary.org/obo/BFO_0000125 has specific dependent at some time http://purl.obolibrary.org/obo/RO_0002086 ends after http://purl.obolibrary.org/obo/RO_0002222 temporally related to http://purl.obolibrary.org/obo/RO_0002354 formed as result of http://purl.obolibrary.org/obo/RO_0002353 output_of http://purl.obolibrary.org/obo/KTAO_0000053 encodes protein http://purl.obolibrary.org/obo/RO_0002330 genomically related to http://purl.obolibrary.org/obo/BFO_0000070 specifically depends on at all times http://purl.obolibrary.org/obo/BFO_0000169 specifically depends on at some time http://purl.obolibrary.org/obo/uberon/core#existence_starts_and_ends_during existence starts and ends during http://purl.obolibrary.org/obo/RO_0002492 existence ends during http://purl.obolibrary.org/obo/RO_0004019 disease has basis in http://purl.obolibrary.org/obo/RO_0004023 causal relationship with disease as subject http://purl.obolibrary.org/obo/RO_0004025 disease causes dysfunction of http://purl.obolibrary.org/obo/RO_0004023 causal relationship with disease as subject http://purl.obolibrary.org/obo/KTAO_0000008 susceptible to be differentially regulated in CKD in anatomic location http://purl.obolibrary.org/obo/KTAO_0000001 susceptible to be differentially regulated in human disease http://purl.obolibrary.org/obo/KTAO_0000002 susceptible to be differentially regulated in CKD in cell http://purl.obolibrary.org/obo/KTAO_0000001 susceptible to be differentially regulated in human disease http://purl.obolibrary.org/obo/KTAO_0000011 susceptible to be differentially regulated in AKI in anatomic location http://purl.obolibrary.org/obo/KTAO_0000001 susceptible to be differentially regulated in human disease http://purl.obolibrary.org/obo/RO_0002506 causal relation between material entities http://purl.obolibrary.org/obo/RO_0002410 causally related to http://purl.obolibrary.org/obo/RO_0004017 realizable has basis in http://purl.obolibrary.org/obo/RO_0002410 causally related to http://purl.obolibrary.org/obo/RO_0004018 is basis for realizable http://purl.obolibrary.org/obo/RO_0002410 causally related to http://purl.obolibrary.org/obo/RO_0004023 causal relationship with disease as subject http://purl.obolibrary.org/obo/RO_0040035 disease relationship http://purl.obolibrary.org/obo/RO_0004046 causally upstream of or within, negative effect http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within http://purl.obolibrary.org/obo/RO_0004047 causally upstream of or within, positive effect http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within http://purl.obolibrary.org/obo/RO_0002588 results in assembly of http://purl.obolibrary.org/obo/RO_0002592 results in organization of http://purl.obolibrary.org/obo/BFO_0000154 temporal projection of spatiotemporal http://purl.obolibrary.org/obo/BFO_0000157 during which exists http://purl.obolibrary.org/obo/BFO_0000156 has temporal occupant http://purl.obolibrary.org/obo/BFO_0000157 during which exists http://purl.obolibrary.org/obo/BFO_0000153 projects onto temporal region http://purl.obolibrary.org/obo/BFO_0000108 exists at http://purl.obolibrary.org/obo/BFO_0000155 occupies temporal region http://purl.obolibrary.org/obo/BFO_0000108 exists at http://purl.obolibrary.org/obo/RO_0002344 results in transport to from or in http://purl.obolibrary.org/obo/RO_0002337 related via localization to http://purl.obolibrary.org/obo/RO_0002590 results in disassembly of http://purl.obolibrary.org/obo/RO_0002592 results in organization of http://purl.obolibrary.org/obo/RO_0012008 results in fusion of http://purl.obolibrary.org/obo/RO_0002592 results in organization of http://purl.obolibrary.org/obo/OBI_0000304 is_manufactured_by has_manufacturer c is_manufactured_by o means that there was a process p in which c was built in which a person, or set of people or machines did the work(bore the "Manufacturer Role", and those people/and or machines were members or of directed by the organization to do this. http://purl.obolibrary.org/obo/RO_0000053 bearer of is bearer of Inverse of characteristic_of http://purl.obolibrary.org/obo/RO_0000056 participates_in participates_in a relation between a continuant and a process, in which the continuant is somehow involved in the process http://purl.obolibrary.org/obo/RO_0000057 has_participant has_participant a relation between a process and a continuant, in which the continuant is somehow involved in the process http://purl.obolibrary.org/obo/RO_0001000 derives from derives_from a relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity http://purl.obolibrary.org/obo/RO_0001001 derives into derives_into a relation between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity http://purl.obolibrary.org/obo/RO_0001015 location of location_of a relation between two independent continuants, the location and the target, in which the target is entirely within the location http://purl.obolibrary.org/obo/RO_0001025 located_in located_in a relation between two independent continuants, the target and the location, in which the target is entirely within the location http://purl.obolibrary.org/obo/BFO_0000066 occurs in unfolds_in b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t http://purl.obolibrary.org/obo/OPMI_0000186 has answer has answer to question An object property that indicates a relation between a question and an answer http://purl.obolibrary.org/obo/VO_0001243 immunizes host immunization for host a shortcut relation that equals to: 'processed material' and (is_specified_output_of some 'vaccine preparation') and ('has function' some ('vaccine function' and ('is realized by' only ('vaccine immunization' and (realizes some ('vaccine host role' and (role_of some 'organism')))))))). The domain of this relation is a vaccine. The range of this relation is a organism. http://purl.obolibrary.org/obo/VO_0003355 immunizes against microbe immunization against microbe a shortcut relation that equals to: processed material and (is_specified_output_of some vaccine preparation) and (has function some (vaccine function and (is realized by only (vaccine immunization and (realizes some ('immunization target role' and (role_of some 'MICROBE')))))))) The domain of this relation is a vaccine. The range of this relation is a microbe (a bacterium, a virus, a fungus, and a parasite) http://purl.obolibrary.org/obo/uberon/core#filtered_through filtered through Relationship between a fluid and a material entity, where the fluid is the output of a realization of a filtration role that inheres in the material entity. http://purl.obolibrary.org/obo/OAE_0001788 has participant quality an object property that represents a relation between a process and a quality, in which the process has a participant that has the quality. http://purl.obolibrary.org/obo/pato#different_in_magnitude_relative_to different_in_magnitude_relative_to q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. http://purl.obolibrary.org/obo/pato#has_cross_section has_cross_section s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2. http://purl.obolibrary.org/obo/RO_0002320 evolutionarily related to A relationship that holds via some environmental process http://purl.obolibrary.org/obo/RO_0002324 developmentally related to A relationship that holds between entities participating in some developmental process (GO:0032502) http://purl.obolibrary.org/obo/uberon/core#site_of site_of c site_of p if c is the bearer of a disposition that is realized by a process that has p as part. http://purl.obolibrary.org/obo/uberon/core#transitively_anteriorly_connected_to transitively anteriorly connected to . http://purl.obolibrary.org/obo/uberon/core#transitively_distally_connected_to transitively distally connected to . http://purl.obolibrary.org/obo/uberon/core#transitively_proximally_connected_to transitively proximally connected to . http://purl.obolibrary.org/obo/BFO_0000067 contains process [copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t http://purl.obolibrary.org/obo/IAO_0000136 is about A (currently) primitive relation that relates an information artifact to an entity. http://purl.obolibrary.org/obo/OBI_0000124 is_supported_by_data The relation between a data item and a conclusion where the conclusion is the output of a data interpreting process and the data item is used as an input to that process http://purl.obolibrary.org/obo/OBI_0000417 achieves_planned_objective This relation obtains between a planned process and a objective specification when the criteria specified in the objective specification are met at the end of the planned process. http://purl.obolibrary.org/obo/OBI_0000833 objective_achieved_by This relation obtains between an objective specification and a planned process when the criteria specified in the objective specification are met at the end of the planned process. http://purl.obolibrary.org/obo/RO_0000059 concretizes A relationship between a specifically dependent continuant and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. Multiple specifically dependent continuants can concretize the same generically dependent continuant. http://purl.obolibrary.org/obo/RO_0002200 has phenotype A relationship that holds between a biological entity and a phenotype. Here a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). The subject of this relationship can be an organism (where the organism has the phenotype, i.e. the qualities inhere in parts of this organism), a genomic entity such as a gene or genotype (if modifications of the gene or the genotype causes the phenotype), or a condition such as a disease (such that if the condition inheres in an organism, then the organism has the phenotype). http://purl.obolibrary.org/obo/RO_0003000 produces a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix. http://purl.obolibrary.org/obo/RO_0003001 produced_by a produced_by b iff some process that occurs_in b has_output a. http://purl.obolibrary.org/obo/BFO_0000117 has occurrent part b has_occurrent_part c = Def. c occurrent_part_of b. (axiom label in BFO2 Reference: [007-001]) http://purl.obolibrary.org/obo/RO_0002573 has modifier A relation that holds between an attribute or a qualifier and another attribute. http://purl.obolibrary.org/obo/so#has_part has_part Inverse of part_of. http://purl.obolibrary.org/obo/so#part_of part_of X part_of Y if X is a subregion of Y. http://purl.obolibrary.org/obo/OPMI_0000216 has digit number A data property that represents a relation between a data type and a number of integer digits that the data type has. http://purl.obolibrary.org/obo/OPMI_0000622 has status content An object property that represents a relation between a status and an information content entity where the status has its content information defined by the information content entity. http://purl.obolibrary.org/obo/BSPO_0000096 anterior_to x anterior_to y iff x is further along the antero-posterior axis than y, towards the head. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail: bearer http://purl.obolibrary.org/obo/BSPO_0000097 distal to x distal_to y iff x is further along the proximo-distal axis than y, towards the appendage tip. A proximo-distal axis extends from tip of an appendage (distal) to where it joins the body (proximal). http://purl.obolibrary.org/obo/BSPO_0000098 dorsal to x dorsal_to y iff x is further along the dorso-ventral axis than y, towards the back. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly). http://purl.obolibrary.org/obo/BSPO_0000099 posterior_to x posterior_to y iff x is further along the antero-posterior axis than y, towards the body/tail. An antero-posterior axis is an axis that bisects an organism from head end to opposite end of body or tail. http://purl.obolibrary.org/obo/BSPO_0000100 proximal_to x proximal_to y iff x is closer to the point of attachment with the body than y. http://purl.obolibrary.org/obo/BSPO_0000102 ventral to x ventral_to y iff x is further along the dorso-ventral axis than y, towards the front. A dorso-ventral axis is an axis that bisects an organism from back (e.g. spinal column) to front (e.g. belly). http://purl.obolibrary.org/obo/BSPO_0000107 deep_to Further away from the surface of the organism. Thus, the muscular layer is deep to the skin, but superficial to the intestines. http://purl.obolibrary.org/obo/BSPO_0000108 superficial_to Near the outer surface of the organism. Thus, skin is superficial to the muscle layer. http://purl.obolibrary.org/obo/RO_0015006 different in magnitude relative to q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. http://purl.obolibrary.org/obo/pr#lacks_part lacks_part A negation of the has_part relation. http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to A mereological relationship or a topological relationship http://purl.obolibrary.org/obo/RO_0002328 functionally related to A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities. http://purl.obolibrary.org/obo/RO_0015011 has cross section s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2. http://purl.obolibrary.org/obo/RO_0015012 reciprocal of q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e. http://purl.obolibrary.org/obo/OPMI_0000481 has identifier An object property that represents a relation between an entity and its corresponding identifier that is owned by the entity. http://purl.obolibrary.org/obo/OPMI_0000501 admitted from An object property that represents a relation between a patient and a site from which the patient was admitted. http://purl.obolibrary.org/obo/OPMI_0000502 discharged to An object property that represents a relation between a patient and a site to which the patient was discharged after a visit. http://purl.obolibrary.org/obo/BFO_0000132 part of occurrent [copied from inverse property 'has occurrent part'] b has_occurrent_part c = Def. c occurrent_part_of b. (axiom label in BFO2 Reference: [007-001]) http://purl.obolibrary.org/obo/BFO_0000176 part of continuant at some time [copied from inverse property 'has continuant part at some time'] b has_continuant_part c at t = Def. c continuant_part_of b at t. (axiom label in BFO2 Reference: [006-001]) http://purl.obolibrary.org/obo/RO_0002330 genomically related to holds between two entities when some genome-level process such as gene expression is involved. This includes transcriptional, spliceosomal events. These relations can be used between either macromolecule entities (such as regions of nucleic acid) or between their abstract informational counterparts. http://purl.obolibrary.org/obo/RO_0002321 ecologically related to A relationship that is mediated in some way by the environment or environmental feature (ENVO:00002297) http://purl.obolibrary.org/obo/uberon/core#conduit_for conduit for x is a conduit for y iff y passes through the lumen of x. http://purl.obolibrary.org/obo/KTAO_0000001 susceptible to be differentially regulated in human disease A shortcut object property that represents a relation between a biological entity and a material entity inside a human patient where the biological entity is susceptible to be differentially regulated in the material entity (e.g., cell or anatomic entity) of a human patient with a specific disease. http://purl.obolibrary.org/obo/IAO_0000235 denoted by inverse of the relation 'denotes' http://purl.obolibrary.org/obo/RO_0002134 innervates Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. http://purl.obolibrary.org/obo/BFO_0000178 has continuant part at some time b has_continuant_part c at t = Def. c continuant_part_of b at t. (axiom label in BFO2 Reference: [006-001]) http://purl.obolibrary.org/obo/RO_0002479 has part that occurs in p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c. http://purl.obolibrary.org/obo/RO_0002609 related via dependence to A relationship that holds between two entities, where the relationship holds based on the presence or absence of statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes. http://purl.obolibrary.org/obo/OPMI_0000424 has sex-specific susceptibility to An object property that represents a relation between a person with a biological sex and a process where the person has a specific susceptbility to a process http://purl.obolibrary.org/obo/RO_0002201 phenotype of inverse of has phenotype http://purl.obolibrary.org/obo/OPMI_0000069 executed in A shortcut relation that is concretized and realized in some process. http://purl.obolibrary.org/obo/RO_0002337 related via localization to A relationship that holds via some process of localization http://purl.obolibrary.org/obo/VO_0000531 has vaccine allergen a object property that specifies a relation between a vaccine and a vaccine allergen http://purl.obolibrary.org/obo/RO_0040035 disease relationship This relation groups relations between diseases and any other kind of entity. http://purl.obolibrary.org/obo/BFO_0000054 realized in realized_in http://purl.obolibrary.org/obo/BFO_0000053 is_bearer_of bearer_of http://purl.obolibrary.org/obo/mondo#disease_causes_feature disease causes feature http://purl.obolibrary.org/obo/mondo#disease_has_basis_in_development_of disease_has_basis_in_development_of http://purl.obolibrary.org/obo/mondo#predisposes_towards predisposes towards http://purl.obolibrary.org/obo/BFO_0000126 has spatiotemporal occupant http://purl.obolibrary.org/obo/BFO_0000130 occupies spatiotemporal region http://purl.obolibrary.org/obo/BFO_0000151 projects onto spatial region at some time http://purl.obolibrary.org/obo/BFO_0000152 spatial projection of spatiotemporal at some time http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#CI_ChemClass CI_ChemClass http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#CI_with CI_with http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#Class_Code Class_Code http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#Class_Description Class_Description http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#Display_Name Display_Name http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#FDA_UNII FDA_UNII http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#Level Level http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#MeSH_CUI MeSH_CUI http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#MeSH_DUI MeSH_DUI http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#MeSH_Definition MeSH_Definition http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#MeSH_Name MeSH_Name http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#NUI NUI http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#Print_Name Print_Name http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#Product_Component Product_Component http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#RxNorm_CUI RxNorm_CUI http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#RxNorm_Name RxNorm_Name http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#Strength Strength http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#Synonym Synonym http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#UMLS_CUI UMLS_CUI http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#Units Units http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#VANDF_Record VANDF_Record http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#VA_National_Formulary_Name VA_National_Formulary_Name http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#VUID VUID http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#has_Ingredient has_Ingredient http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#has_MoA has_MoA http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#has_PE has_PE http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#has_PK has_PK http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#induces induces http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#may_prevent may_prevent http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#may_treat may_treat http://purl.obolibrary.org/obo/KTAO_0000049 biomarker related http://purl.obolibrary.org/obo/uberon/core#channels_from channels_from http://purl.obolibrary.org/obo/uberon/core#channels_into channels_into http://purl.obolibrary.org/obo/BFO_0000055 realizes http://purl.obolibrary.org/obo/IAO_0000004 has measurement value http://purl.obolibrary.org/obo/OBI_0001688 has organization member http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#SNOMED_CID SNOMED_CID http://purl.obolibrary.org/obo/exo.obo#interacts_with interacts_with http://purl.obolibrary.org/obo/exo.obo#interacts_with_an_exposure_receptor_via interacts_with_an_exposure_receptor_via http://purl.obolibrary.org/obo/exo.obo#interacts_with_an_exposure_stressor_via interacts_with_an_exposure stressor_via http://purl.obolibrary.org/obo/mondo#disease_shares_features_of disease shares features of http://purl.obolibrary.org/obo/chebi#has_parent_hydride has parent hydride http://purl.obolibrary.org/obo/chebi#is_conjugate_acid_of is conjugate acid of http://purl.obolibrary.org/obo/chebi#is_conjugate_base_of is conjugate base of http://purl.obolibrary.org/obo/chebi#is_substituent_group_from is substituent group from http://purl.obolibrary.org/obo/BFO_0000083 occupies spatial region at some time http://purl.obolibrary.org/obo/BFO_0000123 has spatial occupant at some time http://purl.obolibrary.org/obo/RO_0002487 relation between physical entity and a process or stage http://purl.obolibrary.org/obo/so#has_quality has_quality http://purl.obolibrary.org/obo/BFO_0000125 has specific dependent at some time http://purl.obolibrary.org/obo/OMRSE_00000020 is-aggregate-of http://purl.obolibrary.org/obo/CL_4030045 lacks_part http://purl.obolibrary.org/obo/RO_0002222 temporally related to http://purl.obolibrary.org/obo/CL_4030044 has_not_completed http://purl.obolibrary.org/obo/CL_4030046 lacks_plasma_membrane_part http://purl.obolibrary.org/obo/RO_0002502 depends on http://purl.obolibrary.org/obo/cl#lacks_plasma_membrane_part lacks_plasma_membrane_part http://purl.obolibrary.org/obo/cl#lacks_part lacks_part http://purl.obolibrary.org/obo/BFO_0000167 has participant at all times http://purl.obolibrary.org/obo/BFO_0000169 specifically depends on at some time http://purl.obolibrary.org/obo/uberon/core#channel_for channel for http://purl.obolibrary.org/obo/uberon/core#protects protects http://purl.obolibrary.org/obo/uberon/core#subdivision_of subdivision of http://purl.obolibrary.org/obo/uberon/core#transitively_connected_to transitively_connected to http://purl.obolibrary.org/obo/mondo#disease_responds_to disease responds to http://purl.obolibrary.org/obo/OPMI_0000185 form generated by http://www.obofoundry.org/ro/ro.owl#has_proper_part has_proper_part http://purl.obolibrary.org/obo/RO_0002005 innervated_by http://purl.obolibrary.org/obo/cl#has_completed has_completed http://purl.obolibrary.org/obo/cl#has_not_completed has_not_completed http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#Status Status http://purl.obolibrary.org/obo/BFO_0000058 concretized by at some time http://purl.obolibrary.org/obo/BFO_0000059 concretizes at some time http://purl.obolibrary.org/obo/BFO_0000157 during which exists http://purl.obolibrary.org/obo/BFO_0000108 exists at http://purl.obolibrary.org/obo/OPMI_0000306 quality measured by year http://purl.obolibrary.org/obo/OPMI_0000366 has process quality