Term IRI Term label Parent term IRI Parent term label Alternative term Definition http://purl.obolibrary.org/obo/MPATH_889 Hirano body http://purl.obolibrary.org/obo/MPATH_45 protein deposition intracellular aggregates of actin and actin-associated proteins first observed in neurons (nerve cells) by Asao Hirano. PMID: 21978358 http://purl.obolibrary.org/obo/MPATH_124 infarct http://purl.obolibrary.org/obo/MPATH_105 circulatory disorder An area of necrosis resulting from a sudden cessation of arterial or venous blood supply. http://purl.obolibrary.org/obo/MPATH_27 arthrosis http://purl.obolibrary.org/obo/MPATH_25 tissue specific degenerative process Changes characterized by erosion of articular cartilage, either primary or secondary to trauma or other conditions. Not primarily an inflammatory process. http://purl.obolibrary.org/obo/MPATH_287 islet cell adenoma http://purl.obolibrary.org/obo/MPATH_270 adenoma Usually pancreatic B cell derived tumors mostly producing insulin. (M- 8150/0). http://purl.obolibrary.org/obo/MPATH_34 amyloid deposition http://purl.obolibrary.org/obo/MPATH_33 intracellular and extracellular accumulation Extracellular deposition of amyloid protein. http://purl.obolibrary.org/obo/MPATH_387 odontoma http://purl.obolibrary.org/obo/MPATH_379 odontogenic tumor Hamartomatous malformation of odontogenic tissue. It may vary from nondescript masses of dental tissue (complex odontoma) to multiple well-formed teeth (compound odontoma). Cf ameloblastic fibro-odontoma. (M-9280/0). http://purl.obolibrary.org/obo/MPATH_429 myxomatous tumor http://purl.obolibrary.org/obo/MPATH_404 soft tissue tumor Neoplasms resembling primitive mesenchymal tissue with a soft mucous matrix. http://purl.obolibrary.org/obo/MPATH_574 nephroblastomatosis http://purl.obolibrary.org/obo/MPATH_64 developmental dysplasia Persistence of metanephrogenic blastema or its presence in the wrong place or at the wrong time. Associated with hyperplastic nephrogenic rests. http://purl.obolibrary.org/obo/MPATH_622 steatosis http://purl.obolibrary.org/obo/MPATH_33 intracellular and extracellular accumulation Abnormal retention of lipids within a cell. Physically apparent as lipid within liposomes of parenchymal cells. http://purl.obolibrary.org/obo/MPATH_718 pre-sacral teratoma http://purl.obolibrary.org/obo/MPATH_322 teratoma Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Pre-sacral tumors located in the retrorectal space between the rectum and the sacrococcygeal part of the spine. http://purl.obolibrary.org/obo/MPATH_98 lymphangiectasis http://purl.obolibrary.org/obo/MPATH_89 cardiovascular developmental defect A stretching and widening of the lymphatic vessels. http://purl.obolibrary.org/obo/MPATH_418 liposarcoma http://purl.obolibrary.org/obo/MPATH_551 sarcoma Malignant neoplasms which probably originate in primitive mesenchymal stem cell populations differentiating down a lipomatous pathway. (M-8850/3). http://purl.obolibrary.org/obo/MPATH_10 gangrene http://purl.obolibrary.org/obo/MPATH_4 necrosis Extensive necrosis from whatever cause, often following chronic ischemia. http://purl.obolibrary.org/obo/MPATH_100 placental abnormality http://purl.obolibrary.org/obo/MPATH_86 organ specific developmental defect Defect in placental growth, differentiation of circulation; maternal or embryonic component. http://purl.obolibrary.org/obo/MPATH_101 glycogen cell defect http://purl.obolibrary.org/obo/MPATH_100 placental abnormality Lack of, displacement of, or abnormality in function or growth of the glycogen cells. http://purl.obolibrary.org/obo/MPATH_102 labyrinth zone defect http://purl.obolibrary.org/obo/MPATH_100 placental abnormality Defect in size, cellular composition, function or organisation of the labyrinthine zone of the placenta. http://purl.obolibrary.org/obo/MPATH_103 placental vascular defect http://purl.obolibrary.org/obo/MPATH_100 placental abnormality Any defect in the maternal or embryonic placental circulation. http://purl.obolibrary.org/obo/MPATH_104 spongiotrophoblast defect http://purl.obolibrary.org/obo/MPATH_100 placental abnormality Defect in size, cellular composition, function or organisation of the spongiotrophoblast zone of the placenta. http://purl.obolibrary.org/obo/MPATH_106 fluid accumulation http://purl.obolibrary.org/obo/MPATH_105 circulatory disorder Abnormal accumulation of fluid; blood or lymph. http://purl.obolibrary.org/obo/MPATH_107 congestion http://purl.obolibrary.org/obo/MPATH_106 fluid accumulation Presence of an abnormal amount of fluid (but especially of blood) in the vessels or passages of a part or organ. http://purl.obolibrary.org/obo/MPATH_108 disseminated intravascular coagulation http://purl.obolibrary.org/obo/MPATH_105 circulatory disorder A syndrome consequent to uncontrolled activation of blood clotting factors leading to disseminated platelet lysis, and fibrin deposition, ultimately leading to bleeding and necrosis as a consequence of inhibition of fibrin polymerisation by degradation products. http://purl.obolibrary.org/obo/MPATH_109 edema http://purl.obolibrary.org/obo/MPATH_106 fluid accumulation An accumulation of an excessive amount of watery fluid in cells or intercellular tissues. http://purl.obolibrary.org/obo/MPATH_11 hemorrhagic necrosis http://purl.obolibrary.org/obo/MPATH_4 necrosis Necrosis associated with local hemorrhage. http://purl.obolibrary.org/obo/MPATH_111 air embolism http://purl.obolibrary.org/obo/MPATH_110 embolus An bubble of air occluding flow through a blood or lymphatic vessel. http://purl.obolibrary.org/obo/MPATH_112 amniotic fluid embolism http://purl.obolibrary.org/obo/MPATH_110 embolus Occlusion of vessels caused by entry of amniotic fluid, cell and debris into the maternal circulation. http://purl.obolibrary.org/obo/MPATH_113 atrial embolism http://purl.obolibrary.org/obo/MPATH_110 embolus Occlusion of the outflow tract of the right atrium by a thrombus. http://purl.obolibrary.org/obo/MPATH_114 bone marrow embolism http://purl.obolibrary.org/obo/MPATH_110 embolus Occlusion of vessels caused by entry of bone marrow, often fatty debris into the circulation. Usually following trauma. http://purl.obolibrary.org/obo/MPATH_115 fat embolism http://purl.obolibrary.org/obo/MPATH_110 embolus Occlusion of vessels caused by entry of lipid or fatty cells into the circulation. Usually following trauma. http://purl.obolibrary.org/obo/MPATH_116 pulmonary embolism http://purl.obolibrary.org/obo/MPATH_110 embolus Occlusion of pulmonary vessels by an embolus. http://purl.obolibrary.org/obo/MPATH_117 skin embolism http://purl.obolibrary.org/obo/MPATH_110 embolus Occlusion of vessels, usually small arterioles in the dermis by various emboli. http://purl.obolibrary.org/obo/MPATH_118 systemic embolism http://purl.obolibrary.org/obo/MPATH_110 embolus Production of systemic vessel occlusion by emboli released from the left side of the heart, or the aorta. http://purl.obolibrary.org/obo/MPATH_12 liquefactive necrosis http://purl.obolibrary.org/obo/MPATH_4 necrosis Soft or fluid tissue remains of a circumscribed area of necrosis digested by proteolytic enzymes. http://purl.obolibrary.org/obo/MPATH_122 petechia http://purl.obolibrary.org/obo/MPATH_119 hemorrhage and non-specified extravasation Small hemorrhagic spots in the skin caused by blood vessel breakdown. http://purl.obolibrary.org/obo/MPATH_123 purpura http://purl.obolibrary.org/obo/MPATH_119 hemorrhage and non-specified extravasation Purple and variously colored lesions caused by extensive haemorrhage into the skin through ecchymoses/petechia. http://purl.obolibrary.org/obo/MPATH_125 thrombosis http://purl.obolibrary.org/obo/MPATH_105 circulatory disorder Presence of an occluding or mural thrombus in a blood vessel. http://purl.obolibrary.org/obo/MPATH_128 intra-epithelial neoplasia http://purl.obolibrary.org/obo/MPATH_556 potentially cancerous lesions Non-invasive changes characterized by alteration in the size, shape and organization of the cellular components of an epithelial tissue. Do not confuse with developmental dysplasia MPATH:64. http://purl.obolibrary.org/obo/MPATH_13 piecemeal necrosis http://purl.obolibrary.org/obo/MPATH_4 necrosis Sensu; hepaticobiliary system. Loss and degeneration of hepatocytes at the portal-lobular interface producing a moth-eaten irregular appearance. Piecemeal necrosis is associated with a lymphocytic infiltrate. http://purl.obolibrary.org/obo/MPATH_130 mild intra-epithelial neoplasia http://purl.obolibrary.org/obo/MPATH_128 intra-epithelial neoplasia Mild non-invasive changes in cell morphology and tissue architecture confined to the epithelium alone. http://purl.obolibrary.org/obo/MPATH_131 moderate intra-epithelial epithelial neoplasia http://purl.obolibrary.org/obo/MPATH_128 intra-epithelial neoplasia Moderate non-invasive changes in cell morphology and tissue architecture confined to the epithelium alone. http://purl.obolibrary.org/obo/MPATH_132 severe intra-epithelial neoplasia http://purl.obolibrary.org/obo/MPATH_128 intra-epithelial neoplasia Severe non-invasive malignancy associated changes in cell morphology and tissue architecture confined to the epithelium alone. http://purl.obolibrary.org/obo/MPATH_133 hypoplasia http://purl.obolibrary.org/obo/MPATH_604 defective growth and differentiation process Small organ or structure; failure to develop to normal size. http://purl.obolibrary.org/obo/MPATH_134 hyperplasia http://purl.obolibrary.org/obo/MPATH_604 defective growth and differentiation process An increase in cell numbers in comparison to normal as a consequence of increased cell proliferation. Non -neoplastic process. http://purl.obolibrary.org/obo/MPATH_135 epithelial and stromal hyperplasia http://purl.obolibrary.org/obo/MPATH_602 hyperplastic tissue Abnormal proliferation of epithelial and stromal cells. http://purl.obolibrary.org/obo/MPATH_136 fibroepithelial polyp http://purl.obolibrary.org/obo/MPATH_138 epithelial hyperplasia A polypoid outgrowth of both epidermis and dermal fibrovascular tissue. http://purl.obolibrary.org/obo/MPATH_137 fibroglandular hyperplasia http://purl.obolibrary.org/obo/MPATH_135 epithelial and stromal hyperplasia Benign proliferation of glandular epithelium accompanied by proliferation of fibroblastic stroma. http://purl.obolibrary.org/obo/MPATH_138 epithelial hyperplasia http://purl.obolibrary.org/obo/MPATH_602 hyperplastic tissue Abnormal proliferation of epithelial cells and epithelial components. http://purl.obolibrary.org/obo/MPATH_139 goblet cell hyperplasia http://purl.obolibrary.org/obo/MPATH_138 epithelial hyperplasia Benign proliferation of goblet cells. http://purl.obolibrary.org/obo/MPATH_140 hyperplastic polyp http://purl.obolibrary.org/obo/MPATH_491 polyp A benign polyp, usually in the colon, showing hyperplasia. http://purl.obolibrary.org/obo/MPATH_141 inflammatory polyp http://purl.obolibrary.org/obo/MPATH_491 polyp A projecting mass of granulation tissue which may become covered by regenerating epithelium. http://purl.obolibrary.org/obo/MPATH_142 intraductal hyperplasia http://purl.obolibrary.org/obo/MPATH_138 epithelial hyperplasia Benign hyperplasia of the ducts of the mammary gland. Ducts exhibit more than the usual two layer epithelium (inner cuboidal to columnar cells; outer layer of myoepithelium) without cytological atypia. http://purl.obolibrary.org/obo/MPATH_143 microglandular hyperplasia http://purl.obolibrary.org/obo/MPATH_138 epithelial hyperplasia Benign proliferation of glandular epithelia, eg. Endocervical glands. Consists of tightly packed glandular or tubular units, which vary in size, lined by a flattened-to-cuboidal epithelium. http://purl.obolibrary.org/obo/MPATH_144 myoepithelial hyperplasia http://purl.obolibrary.org/obo/MPATH_138 epithelial hyperplasia Benign proliferation of glandular myoepithelial cells. http://purl.obolibrary.org/obo/MPATH_145 fat cell hyperplasia http://purl.obolibrary.org/obo/MPATH_602 hyperplastic tissue Benign proliferation of adipose tissue. http://purl.obolibrary.org/obo/MPATH_147 lymphoid hyperplasia http://purl.obolibrary.org/obo/MPATH_602 hyperplastic tissue Benign enlargement of lymphoid tissues. http://purl.obolibrary.org/obo/MPATH_148 mesothelial hyperplasia http://purl.obolibrary.org/obo/MPATH_602 hyperplastic tissue Benign proliferation of mesothelial cells lining body cavities presenting as small solid cell clusters or multiple layers with columnar morphology and delicate eosinophilic cytoplasm. http://purl.obolibrary.org/obo/MPATH_15 general degenerative process http://purl.obolibrary.org/obo/MPATH_14 process of degenerative change Change of tissue to a lower state of integrity or less functional form, as in heart failure. http://purl.obolibrary.org/obo/MPATH_151 actinic keratosis http://purl.obolibrary.org/obo/MPATH_556 potentially cancerous lesions Discrete, flat or elevated, verrucous, keratotic lesions. Epidermal changes are characterized by acanthosis, parakeratosis, and dyskeratoses. Dysplastic change is present and the keratinocytes vary in size and shape. Associated with UV exposure in humans. Not defined in mice to date. http://purl.obolibrary.org/obo/MPATH_152 basal cell hyperplasia http://purl.obolibrary.org/obo/MPATH_149 squamous hyperplasia Benign proliferation of the basal layer cells of the skin. http://purl.obolibrary.org/obo/MPATH_153 hypergranulosis http://purl.obolibrary.org/obo/MPATH_149 squamous hyperplasia Increased thickness of the granular layer of a stratified squamous epithelium, associated with hyperorthokeratosis. http://purl.obolibrary.org/obo/MPATH_155 orthokeratosis http://purl.obolibrary.org/obo/MPATH_154 hyperkeratosis Thickening of the anuclear cell layer limited to the stratum corneum, as in a stratified squamous epithelium. http://purl.obolibrary.org/obo/MPATH_157 pseudoepithelioma/pseudocarcinoma http://purl.obolibrary.org/obo/MPATH_149 squamous hyperplasia Benign hyperplasia and down-growth of epidermal cells. Microscopically resembling well-differentiated squamous cell carcinoma. http://purl.obolibrary.org/obo/MPATH_158 seborrheic keratosis http://purl.obolibrary.org/obo/MPATH_149 squamous hyperplasia Superficial, benign, verrucous, often pigmented, greasy lesions consisting of proliferating epidermal cells, resembling basal cells, enclosing cornifying cysts. http://purl.obolibrary.org/obo/MPATH_159 hypertrophy http://purl.obolibrary.org/obo/MPATH_604 defective growth and differentiation process Increase in size or mass of a cell, tissue or organ without increase in cell proliferation. Cf. Hyperplasia MPATH: 133. http://purl.obolibrary.org/obo/MPATH_16 myxoid/myxomatous degeneration http://purl.obolibrary.org/obo/MPATH_15 general degenerative process A conversion of the connective tissues into a gelatinous or mucous substance. http://purl.obolibrary.org/obo/MPATH_161 cartilaginous metaplasia http://purl.obolibrary.org/obo/MPATH_605 metaplastic tissue Metaplasia resulting in heterotopic formation of cartilage. http://purl.obolibrary.org/obo/MPATH_163 apocrine metaplasia http://purl.obolibrary.org/obo/MPATH_162 epithelial metaplasia Alteration of acinar epithelium of, for example, mammary tissue to resemble apocrine glands. http://purl.obolibrary.org/obo/MPATH_165 glandular metaplasia http://purl.obolibrary.org/obo/MPATH_162 epithelial metaplasia Development of heterotopic glandular epithelia. http://purl.obolibrary.org/obo/MPATH_166 goblet cell metaplasia http://purl.obolibrary.org/obo/MPATH_162 epithelial metaplasia Metaplasia resulting in formation of mucus secreting goblet cells. http://purl.obolibrary.org/obo/MPATH_167 intestinal metaplasia http://purl.obolibrary.org/obo/MPATH_162 epithelial metaplasia Appearance of heterotopic intestinal epithelium. http://purl.obolibrary.org/obo/MPATH_168 lipomatous metaplasia http://purl.obolibrary.org/obo/MPATH_605 metaplastic tissue Metaplasia resulting in formation of fat cells. http://purl.obolibrary.org/obo/MPATH_169 nephrogenic metaplasia http://purl.obolibrary.org/obo/MPATH_162 epithelial metaplasia .A rare benign neoplasm of the mucosa of the urinary bladder or the urethra, consisting of tubular structures resembling those of the nephron. http://purl.obolibrary.org/obo/MPATH_17 subcellular defect http://purl.obolibrary.org/obo/MPATH_1 cell and tissue damage Defect of a subcellular structure or organelle. http://purl.obolibrary.org/obo/MPATH_170 oncocytic metaplasia http://purl.obolibrary.org/obo/MPATH_162 epithelial metaplasia Appearance of oncocytic cells in for example an epithelium or tumor. http://purl.obolibrary.org/obo/MPATH_171 squamous metaplasia http://purl.obolibrary.org/obo/MPATH_162 epithelial metaplasia Change of a glandular or mucosal epithelium into squamous epithelium. http://purl.obolibrary.org/obo/MPATH_172 transitional cell metaplasia http://purl.obolibrary.org/obo/MPATH_162 epithelial metaplasia Metaplastic response of the transitional epithelium, for example in the bladder to give squamous metaplasia and glandular metaplasia for example. http://purl.obolibrary.org/obo/MPATH_173 myeloid metaplasia http://purl.obolibrary.org/obo/MPATH_512 myeloproliferative disease A progressive disease of the bone marrow where neoplastic bone marrow stem cells lodge and grow at sites outside the bone marrow. http://purl.obolibrary.org/obo/MPATH_174 osseous metaplasia http://purl.obolibrary.org/obo/MPATH_605 metaplastic tissue Metaplasia resulting in formation of bone. http://purl.obolibrary.org/obo/MPATH_177 angiogenesis http://purl.obolibrary.org/obo/MPATH_176 connective tissue replacement Aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network by vasculogenesis. http://purl.obolibrary.org/obo/MPATH_178 extracellular matrix deposition http://purl.obolibrary.org/obo/MPATH_176 connective tissue replacement Abnormal deposition of extracellular matrix proteins or other components. http://purl.obolibrary.org/obo/MPATH_179 fibrin deposition http://purl.obolibrary.org/obo/MPATH_176 connective tissue replacement Deposition of fibrin. http://purl.obolibrary.org/obo/MPATH_18 cytoskeletal defect http://purl.obolibrary.org/obo/MPATH_17 subcellular defect Defect in the structure or function of the cytoskeleton. http://purl.obolibrary.org/obo/MPATH_180 fibroblast proliferation http://purl.obolibrary.org/obo/MPATH_176 connective tissue replacement Abnormal or reactive proliferation of fibroblasts. http://purl.obolibrary.org/obo/MPATH_182 gliosis http://purl.obolibrary.org/obo/MPATH_176 connective tissue replacement Proliferation of astrocytes in an area of damage in the brain or spinal cord. http://purl.obolibrary.org/obo/MPATH_183 granulation tissue http://purl.obolibrary.org/obo/MPATH_607 healing and repair structure Newly formed connective (vascular or fibrous)tissue caused by inflammation or healing (repair) processes. Microscopically consists of capillaries fibroblastic cells and inflammatory cells. http://purl.obolibrary.org/obo/MPATH_185 parenchymal regeneration http://purl.obolibrary.org/obo/MPATH_175 healing and repair process Post-injury regeneration of the functional tissue parenchyma. Eg. Liver. http://purl.obolibrary.org/obo/MPATH_186 complete parenchymal regeneration http://purl.obolibrary.org/obo/MPATH_185 parenchymal regeneration Complete healing through parenchymal regeneration - no fibrosis. http://purl.obolibrary.org/obo/MPATH_187 incomplete parenchymal regeneration http://purl.obolibrary.org/obo/MPATH_185 parenchymal regeneration Incomplete healing usually accompanied by fibrosis. http://purl.obolibrary.org/obo/MPATH_189 hypersensitivity disease http://purl.obolibrary.org/obo/MPATH_188 immunopathological process Immune response resulting in tissue injury. http://purl.obolibrary.org/obo/MPATH_19 endoplasmic reticulum defect http://purl.obolibrary.org/obo/MPATH_17 subcellular defect Defect in the structure or function of the endoplasmic reticulum. http://purl.obolibrary.org/obo/MPATH_190 type I hypersensitivity http://purl.obolibrary.org/obo/MPATH_189 hypersensitivity disease This is manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized. It is IgE-mediated, and mast cell activation and degranulation are hallmarks. http://purl.obolibrary.org/obo/MPATH_191 type II hypersensitivity http://purl.obolibrary.org/obo/MPATH_189 hypersensitivity disease Caused by an antibody/antigen reaction: antibodies are directly or indirectly cytotoxic to antigens on cell surfaces or in connective tissues. http://purl.obolibrary.org/obo/MPATH_192 type III hypersensitivity http://purl.obolibrary.org/obo/MPATH_189 hypersensitivity disease Tissue injury mediated by immune complexes. Generally involves immune complexes formed in the blood via antibodies encountering circulating antigens. Immune complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury. http://purl.obolibrary.org/obo/MPATH_193 type IV hypersensitivity http://purl.obolibrary.org/obo/MPATH_189 hypersensitivity disease An antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation. The response is seen at the area of contact. http://purl.obolibrary.org/obo/MPATH_199 immune mediated thrombocytopenia http://purl.obolibrary.org/obo/MPATH_212 inflammation A condition resulting from an increased rate of immune mediated platelet destruction. http://purl.obolibrary.org/obo/MPATH_20 golgi defect http://purl.obolibrary.org/obo/MPATH_17 subcellular defect Defect in the structure or function of the golgi apparatus. http://purl.obolibrary.org/obo/MPATH_202 immunodeficiency disease http://purl.obolibrary.org/obo/MPATH_188 immunopathological process Defective immune response; can be primary due to defect in immune system or secondary/acquired due to disease. http://purl.obolibrary.org/obo/MPATH_206 primary immunodeficiency disease http://purl.obolibrary.org/obo/MPATH_202 immunodeficiency disease Disease due to primary molecular or cellular defect in the immune system or its development. http://purl.obolibrary.org/obo/MPATH_207 immunodeficiency - lymphoid defect http://purl.obolibrary.org/obo/MPATH_206 primary immunodeficiency disease Primary defect in the lymphoid arm of the immune system. http://purl.obolibrary.org/obo/MPATH_208 immunodeficiency - myeloid/phagocytic defect http://purl.obolibrary.org/obo/MPATH_206 primary immunodeficiency disease Primary defect in the myeloid arm of the immune system. http://purl.obolibrary.org/obo/MPATH_209 secondary immunodeficiency disease http://purl.obolibrary.org/obo/MPATH_202 immunodeficiency disease Defect in the immune system subsequent to external injury, infection, ablation or deficiency. http://purl.obolibrary.org/obo/MPATH_21 lysosomal defect http://purl.obolibrary.org/obo/MPATH_17 subcellular defect Defect in the structure or function of the lysosomes. http://purl.obolibrary.org/obo/MPATH_210 acquired immunodeficiency http://purl.obolibrary.org/obo/MPATH_209 secondary immunodeficiency disease Defect in the immune system subsequent to external injury, infection or ablation. http://purl.obolibrary.org/obo/MPATH_211 failed transfer of maternal immunoglobulin http://purl.obolibrary.org/obo/MPATH_209 secondary immunodeficiency disease Defect in the immune system subsequent to failure to attain passive immunity from maternal transfer of immunoglobulins. http://purl.obolibrary.org/obo/MPATH_215 granulomatous inflammation http://purl.obolibrary.org/obo/MPATH_212 inflammation Nodular inflammatory reaction, containing compactly grouped epithelioid cells, giant cells, and other macrophages. The basic inflammatory unit is termed a granuloma. http://purl.obolibrary.org/obo/MPATH_216 necrotic inflammation http://purl.obolibrary.org/obo/MPATH_212 inflammation Acute inflammatory reaction in which the predominant histological change is rapid diffuse necrosis throughout the affected tissue. http://purl.obolibrary.org/obo/MPATH_22 mitochondrial defect http://purl.obolibrary.org/obo/MPATH_17 subcellular defect Defect in the structure or function of the mitochondria. http://purl.obolibrary.org/obo/MPATH_220 apocrine adenocarcinoma http://purl.obolibrary.org/obo/MPATH_268 adenocarcinoma Carcinoma of the glandular epithelium of apocrine glands (M-8401/3). http://purl.obolibrary.org/obo/MPATH_221 apocrine adenoma http://purl.obolibrary.org/obo/MPATH_270 adenoma Benign neoplasm of the epithelium of apocrine glands (M-8401/0). http://purl.obolibrary.org/obo/MPATH_222 ceruminous adenocarcinoma http://purl.obolibrary.org/obo/MPATH_268 adenocarcinoma Malignant carcinoma of the ceruminous gland (M-8420/3). http://purl.obolibrary.org/obo/MPATH_223 ceruminous adenoma http://purl.obolibrary.org/obo/MPATH_270 adenoma Benign adenomatous neoplasia of the ceruminous glands of the external auditory meatus (M-8420/0). http://purl.obolibrary.org/obo/MPATH_224 clear cell hidradenoma http://purl.obolibrary.org/obo/MPATH_270 adenoma Tumor derived from eccrine sweat glands composed of clear glycogen rich cells. ( M-84020 ). http://purl.obolibrary.org/obo/MPATH_225 eccrine gland adenocarcinoma http://purl.obolibrary.org/obo/MPATH_268 adenocarcinoma Malignant neoplasm of the eccrine gland (M-8413/3). http://purl.obolibrary.org/obo/MPATH_226 eccrine gland adenoma http://purl.obolibrary.org/obo/MPATH_270 adenoma Benign neoplasm of the eccrine gland (M-8408/0). http://purl.obolibrary.org/obo/MPATH_227 eccrine papillary adenoma http://purl.obolibrary.org/obo/MPATH_270 adenoma Papillary form of eccrine sweat gland adenoma. (M -8408/0). http://purl.obolibrary.org/obo/MPATH_228 papillary hidradenoma http://purl.obolibrary.org/obo/MPATH_270 adenoma Benign apocrine sweat gland tumor (8405/0). http://purl.obolibrary.org/obo/MPATH_229 sebaceous adenocarcinoma http://purl.obolibrary.org/obo/MPATH_268 adenocarcinoma Malignant neoplasm of the sebaceous cells - rare areas of differentiation, severe nuclear atypia (M-8410/3). http://purl.obolibrary.org/obo/MPATH_23 peroxysomal defect http://purl.obolibrary.org/obo/MPATH_17 subcellular defect Defect in the structure or function of the peroxysomes. http://purl.obolibrary.org/obo/MPATH_230 sebaceous adenoma http://purl.obolibrary.org/obo/MPATH_270 adenoma Adenoma of sebaceous cells; regular architecture of gland not mantained. Large numbers of immature germinative cells present. Mitoses. (M-8410/0). http://purl.obolibrary.org/obo/MPATH_231 syringoma http://purl.obolibrary.org/obo/MPATH_219 adnexal and skin appendage tumor A benign, often multiple, sometimes eruptive neoplasm of the sweat gland ducts composed of very small round cysts. (M-8407/0). http://purl.obolibrary.org/obo/MPATH_237 angiokeratoma http://purl.obolibrary.org/obo/MPATH_235 blood vessel tumor An intradermal capillary telangiectasis with hyperkeratosis and acanthosis (M-9141/0). http://purl.obolibrary.org/obo/MPATH_24 plasma membrane defect http://purl.obolibrary.org/obo/MPATH_17 subcellular defect Defect in the structure or function of the plasma membrane. http://purl.obolibrary.org/obo/MPATH_241 hemangiopericytoma http://purl.obolibrary.org/obo/MPATH_235 blood vessel tumor A vascular, usually benign, neoplasm composed of round and spindle cells derived from the pericytes and surround endothelium-lined vessels. (M-9150/0/1/3). http://purl.obolibrary.org/obo/MPATH_245 choroid plexus carcinoma http://purl.obolibrary.org/obo/MPATH_565 tumors of neurepithelial tissue Malignant neoplasm derived from the epithelial cells of the choroid plexus. (M-9390/3). http://purl.obolibrary.org/obo/MPATH_253 sub-ependymoma http://purl.obolibrary.org/obo/MPATH_249 glioma Neoplasm derived from sub-ependymal astrocytes (M-9383/1). http://purl.obolibrary.org/obo/MPATH_255 adenoacanthoma http://purl.obolibrary.org/obo/MPATH_254 complex tumor Mixed tumor of glandular epithelia with squamous and glandular diffferentiation. (M-8570/3). http://purl.obolibrary.org/obo/MPATH_256 carcinosarcoma http://purl.obolibrary.org/obo/MPATH_551 sarcoma Possible origin from smooth muscle cells or pluripotential embryonic mesenchymal cells. May show up to three cellular componants including carcinoma and sarcoma type appearances. (M-8980/3). http://purl.obolibrary.org/obo/MPATH_257 craniopharyngioma http://purl.obolibrary.org/obo/MPATH_254 complex tumor A benign or malignant neoplasm, which may be cystic, developing from the epithelium of Rathke`s pouch and occuring with or close to the pituitary gland. (M-9350/1). http://purl.obolibrary.org/obo/MPATH_258 mesodermal mixed tumor http://purl.obolibrary.org/obo/MPATH_254 complex tumor Neoplasm showing multiple phases, derived from mesoderm (M-8951/3). http://purl.obolibrary.org/obo/MPATH_259 mucoepidermoid carcinoma http://purl.obolibrary.org/obo/MPATH_254 complex tumor Most commonly a salivary gland carcinoma of low grade malignancy composed of mucous, epidermoid, and intermediate cells. (M-8430/3). http://purl.obolibrary.org/obo/MPATH_26 alopecia http://purl.obolibrary.org/obo/MPATH_25 tissue specific degenerative process Absence of hair or loss of hair. http://purl.obolibrary.org/obo/MPATH_260 mullerian mixed tumor http://purl.obolibrary.org/obo/MPATH_254 complex tumor Neoplasm usually of the uterus or adnexae containing carcinomatous and sarcomatous elements, sometimes with third or fourth components. (M-8950/3). http://purl.obolibrary.org/obo/MPATH_263 rhabdoid sarcoma http://purl.obolibrary.org/obo/MPATH_551 sarcoma Sarcomatous tumors, presenting a wide histological, ultrastructural, and immunocytochemical spectrum. M-8963/3. http://purl.obolibrary.org/obo/MPATH_265 adenofibroma http://purl.obolibrary.org/obo/MPATH_264 fibroepithelial tumor A benign neoplasm composed of glandular and fibrous tissues, predominantly glandular. (M-9013/0). http://purl.obolibrary.org/obo/MPATH_269 adenocarcinoma in situ http://purl.obolibrary.org/obo/MPATH_556 potentially cancerous lesions A noninvasive abnormal proliferation of glands believed to precede the appearance of invasive adenocarcinoma. (M-8140/2). http://purl.obolibrary.org/obo/MPATH_272 bronchioloalveolar adenoma http://purl.obolibrary.org/obo/MPATH_270 adenoma Benign epithelial neoplasm of the lung. (M-8140/1) 1.2.1.2 in MMHCC classification. http://purl.obolibrary.org/obo/MPATH_273 bronchioloalveolar carcinoma http://purl.obolibrary.org/obo/MPATH_549 carcinoma Malignant epithelial neoplasm of the lung. (M-8250/3) 1.2.3.2, 1.2.3.5 of MMHCC classification. http://purl.obolibrary.org/obo/MPATH_274 clear cell adenocarcinoma http://purl.obolibrary.org/obo/MPATH_268 adenocarcinoma An adenocarcinoma characterised by the presence of varying combinations of clear and hobnail-shaped tumor cells. (M-8310/3). http://purl.obolibrary.org/obo/MPATH_275 comedocarcinoma http://purl.obolibrary.org/obo/MPATH_549 carcinoma Form of carcinoma of the breast or other organ in which plugs of necrotic malignant cells are present in the ducts. (M -8501/3). http://purl.obolibrary.org/obo/MPATH_276 cystadenocarcinoma http://purl.obolibrary.org/obo/MPATH_268 adenocarcinoma Malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. (M-8440/3). http://purl.obolibrary.org/obo/MPATH_279 follicular adenoma http://purl.obolibrary.org/obo/MPATH_270 adenoma Adenoma derived from the follicular cells of the thyroid follicles. Follicular, paipillary and solid forms. M- 8330/0. http://purl.obolibrary.org/obo/MPATH_280 Harderian gland adenoma http://purl.obolibrary.org/obo/MPATH_270 adenoma Adenoma derived from acinar epithelium of the harderian gland. Papillary, cystic, cystic-papillary and acinar forms. http://purl.obolibrary.org/obo/MPATH_281 Harderian gland carcinoma http://purl.obolibrary.org/obo/MPATH_549 carcinoma Malignant tumor derived form acinar epithelium of the Harderian gland. http://purl.obolibrary.org/obo/MPATH_282 infiltrating duct carcinoma http://purl.obolibrary.org/obo/MPATH_549 carcinoma Derived from the mammary ductal epithelium and penetrating the stroma (M-8500/3). http://purl.obolibrary.org/obo/MPATH_284 intraductal papillary carcinoma http://purl.obolibrary.org/obo/MPATH_549 carcinoma Infiltrating tumor with papillary morphology derived from the breast epithelium (M-8503/3). http://purl.obolibrary.org/obo/MPATH_285 intraductal papilloma http://purl.obolibrary.org/obo/MPATH_445 papilloma Benign papilloma arising from ductal epithelium (M- 8503/0 ). http://purl.obolibrary.org/obo/MPATH_286 intraductal papillomatosis http://purl.obolibrary.org/obo/MPATH_267 glandular tumor Diffuse multiple adenomatous papillomas derived from the ductal epithelium of the breast. (M- 8505/0). http://purl.obolibrary.org/obo/MPATH_288 islet cell carcinoma http://purl.obolibrary.org/obo/MPATH_549 carcinoma Rare tumor of the islets of Langerhans, most of which produce insulin. (M- 8150/3). http://purl.obolibrary.org/obo/MPATH_289 lobular carcinoma http://purl.obolibrary.org/obo/MPATH_549 carcinoma A form of breast adenocarcinoma derived from lobular cells. (M-8520/3). http://purl.obolibrary.org/obo/MPATH_29 cataract http://purl.obolibrary.org/obo/MPATH_1 cell and tissue damage Opacity of the lens. http://purl.obolibrary.org/obo/MPATH_290 lobular carcinoma in situ http://purl.obolibrary.org/obo/MPATH_556 potentially cancerous lesions Non-infiltrating form of lobular adenocarcinoma derived from the ductal epithelium. (M-8520/2). http://purl.obolibrary.org/obo/MPATH_292 mucinous cystadenocarcinoma http://purl.obolibrary.org/obo/MPATH_276 cystadenocarcinoma Malignant neoplasm derived from a glandular epithelium, eg. Ovary. Consisting of a solid to cystic mass lined with cuboidal pleomorphic epithelial cells producing a mucinous material. (M- 8470/3). http://purl.obolibrary.org/obo/MPATH_293 mucinous cystadenoma http://purl.obolibrary.org/obo/MPATH_270 adenoma A benign neoplasm derived from glandular epithelium, in which cystic accumulations of mucinous retained secretions are formed. (M-8470/0). http://purl.obolibrary.org/obo/MPATH_294 myoepithelioma http://purl.obolibrary.org/obo/MPATH_270 adenoma Tumor originating in myoepithelial cells of exocrine glandular structures; for example mammary gland, salivary gland and preputial/clitoral glands. (M-8982/0). http://purl.obolibrary.org/obo/MPATH_296 papillary adenoma http://purl.obolibrary.org/obo/MPATH_270 adenoma A benign neoplasm derived from a glandular epithelium, in which solid tumors show papillary structures projecting onto fibrovascular stroma. (M-8260/0). http://purl.obolibrary.org/obo/MPATH_297 papillary cystadenocarcinoma http://purl.obolibrary.org/obo/MPATH_276 cystadenocarcinoma A malignant neoplasm derived from glandular epithelium, in which cysts contain folds or papillary projections into the lumen. (M-8450/3). http://purl.obolibrary.org/obo/MPATH_3 apoptosis http://purl.obolibrary.org/obo/MPATH_2 cell death Energy dependent cell death induced by intrinsic genetic or developmental programme, or external stimuli such as addition or withdrawal of cytokines or trophic factors, radiation, chemotherapeutic agents etc. Characterised by cell shrinkage, increases in membrane permeability, endonucleolyis and nuclear fragmentation resulting in the formation of rapidly endocytosed apoptotic bodies. http://purl.obolibrary.org/obo/MPATH_30 cystic medial necrosis http://purl.obolibrary.org/obo/MPATH_4 necrosis Loss of muscle fibers and elastin in the media of the aorta, with accumulation of mucopolysaccharide. http://purl.obolibrary.org/obo/MPATH_300 pineoblastoma http://purl.obolibrary.org/obo/MPATH_267 glandular tumor Malignant neoplasms which arise from pineoblasts, the primitive pineal stem cells. (M-9362/3). http://purl.obolibrary.org/obo/MPATH_301 pineocytoma http://purl.obolibrary.org/obo/MPATH_267 glandular tumor A tumor arising in the pineal gland that resembles normal pineal parenchyma. (M-9361/1). http://purl.obolibrary.org/obo/MPATH_302 pituicytoma http://purl.obolibrary.org/obo/MPATH_270 adenoma Benign tumor derived from the pituicytes ( glial cells of neurohypophysis) (M-8272/0). http://purl.obolibrary.org/obo/MPATH_303 pseudomyxoma peritonei http://purl.obolibrary.org/obo/MPATH_267 glandular tumor Tumor characterized by extensive spread of a mucin-secreting neoplasm along the peritoneal surfaces (M-8480/6). http://purl.obolibrary.org/obo/MPATH_304 serous adenocarcinoma http://purl.obolibrary.org/obo/MPATH_268 adenocarcinoma Adenocarcinoma from a serous gland producing and containing serous proteinaceous secretions (M-8441/3). http://purl.obolibrary.org/obo/MPATH_305 serous cystadenoma http://purl.obolibrary.org/obo/MPATH_270 adenoma Ovarian cystadenoma composed of cells similar to tubal epithelium (M-8441/0). http://purl.obolibrary.org/obo/MPATH_306 signet ring cell carcinoma http://purl.obolibrary.org/obo/MPATH_268 adenocarcinoma Adenocarcinoma of signet ring type arising from exocrine cells of the gastric mucosa or enterocytes of intestinal mucosa. (M-8490/3). http://purl.obolibrary.org/obo/MPATH_307 thyroid C-cell adenoma http://purl.obolibrary.org/obo/MPATH_270 adenoma Benign neoplasm derived from the calcitonin producing C-cells of the thyroid gland. http://purl.obolibrary.org/obo/MPATH_311 dermoid cyst http://purl.obolibrary.org/obo/MPATH_549 carcinoma Cystic ovarian teratomas with different mature cell types (M-9084/3). http://purl.obolibrary.org/obo/MPATH_313 embryonal carcinoma http://purl.obolibrary.org/obo/MPATH_549 carcinoma Germ cell derived malignant neoplasm of the testis or ovary, composed of anaplastic cells with indistinct cellular borders and large ovoid, round, or bean-shaped nuclei that may have large nucleoli. (M-9070/3 ). http://purl.obolibrary.org/obo/MPATH_314 endodermal sinus tumor http://purl.obolibrary.org/obo/MPATH_549 carcinoma Germ cell derived tumors resembling parietal or visceral yolk sac endoderm derivatives. Abundant eosinophilic matrix surrounding nests and cords of neoplastic cells. (M-9071-3). http://purl.obolibrary.org/obo/MPATH_318 classical seminoma http://purl.obolibrary.org/obo/MPATH_317 seminoma As MPATH:317, but not spermatocytic (M-9061/3). http://purl.obolibrary.org/obo/MPATH_319 spermatocytic seminoma http://purl.obolibrary.org/obo/MPATH_317 seminoma Neoplasm of the testis usually found within the tubule. Some debate as to whether it is of germ cell origin in contrast to classical seminoma. Three types of cells are identified in spermatocytic seminomas: those with small, intermediate, and large nuclei in humans. (M-9063/3). http://purl.obolibrary.org/obo/MPATH_32 glaucoma http://purl.obolibrary.org/obo/MPATH_25 tissue specific degenerative process Increase in the intraocular pressure. http://purl.obolibrary.org/obo/MPATH_320 struma ovarii http://purl.obolibrary.org/obo/MPATH_549 carcinoma Rare ovarian tumor, regarded as monodermal teratoma, in which thyroid tissue has surpassed the other elements; occasionally associated with hyperthyroidism (M-9090/0). http://purl.obolibrary.org/obo/MPATH_326 granulosa cell tumor http://purl.obolibrary.org/obo/MPATH_323 gonadal somatic cell tumor . Derived from sex cord stromal cells. In male thought to be Sertoli cells. (M- 8620/1). http://purl.obolibrary.org/obo/MPATH_329 luteal cell tumor http://purl.obolibrary.org/obo/MPATH_323 gonadal somatic cell tumor Tumor derived from sex cords composed of highly luteinised cells with extensive pale granular cytoplasm. (M- 8610/0). http://purl.obolibrary.org/obo/MPATH_330 ovarian stromal tumor http://purl.obolibrary.org/obo/MPATH_323 gonadal somatic cell tumor Tumor consists of a mixture of granulosa, luteal thecal, Sertoli and stromal cells. (M-8590/1). http://purl.obolibrary.org/obo/MPATH_332 sertoli-leydig cell tumor http://purl.obolibrary.org/obo/MPATH_323 gonadal somatic cell tumor Tumor of the ovary or testis containing granulosa or theca cell elements with a tubular componant of Sertoli cell type and producing simultaneous androgenic and estrogenic effects. (M-8631/0). http://purl.obolibrary.org/obo/MPATH_334 thecoma http://purl.obolibrary.org/obo/MPATH_323 gonadal somatic cell tumor Derived from sex cord stromal cells, spindle shaped cells arranged in whorls or interlacing bundles. (M- 8600/0). http://purl.obolibrary.org/obo/MPATH_337 erythroid leukaemia http://purl.obolibrary.org/obo/MPATH_496 Non-Lymphoid leukaemias Leukaemia with at least 50% of nucleated erythroid cells infiltrating haematopoietic tissue. http://purl.obolibrary.org/obo/MPATH_340 megakaryocytic leukaemia http://purl.obolibrary.org/obo/MPATH_496 Non-Lymphoid leukaemias Leukaemia with at least 50% of megakaryocytic cells infiltrating haematopoietic tissue. http://purl.obolibrary.org/obo/MPATH_341 myelodysplastic disorder http://purl.obolibrary.org/obo/MPATH_508 myeloid dysplasias Haematopoietic proliferation with evidence of trilineage dysplasia. Less than 20% should be blasts. http://purl.obolibrary.org/obo/MPATH_35 bile deposition http://purl.obolibrary.org/obo/MPATH_613 pigmentation Intra- or extracellular deposition of bile pigments and their metabolites. http://purl.obolibrary.org/obo/MPATH_355 cholangiofibroma http://purl.obolibrary.org/obo/MPATH_352 hepatic tumor Develops from cholangiofibrosis, fibrosis of the biliary ducts and is only potentially malignant. http://purl.obolibrary.org/obo/MPATH_362 mesonephroma http://purl.obolibrary.org/obo/MPATH_268 adenocarcinoma Benign or malignant neoplasm of the ovary and corpus uteri, thought to originate in mesonephric structures. (M-9110/3). http://purl.obolibrary.org/obo/MPATH_363 mesonephric tumor http://purl.obolibrary.org/obo/MPATH_362 mesonephroma Tumor beleived to be derived from mesonephric remnants. (M-8310/3). http://purl.obolibrary.org/obo/MPATH_367 carcinoid tumor http://purl.obolibrary.org/obo/MPATH_366 neuroendocrine tumor Carcinoid tumors are of neuroendocrine origin and derived from primitive stem cells. Found predominantly in the lung and gut they are capable of secreting a large range of substances and have a number of histological subtypes. May resemble but are distinct from small cell lung carcinoma in the lung. (M-8240/3). http://purl.obolibrary.org/obo/MPATH_37 ceroid deposition http://purl.obolibrary.org/obo/MPATH_613 pigmentation Intracellular deposition of golden or yellow-brown pigment, acid fast and insoluble in lipid solvents. Believed to be a type of lipofuscin. http://purl.obolibrary.org/obo/MPATH_372 tumorlet http://purl.obolibrary.org/obo/MPATH_366 neuroendocrine tumor Small disseminated foci of atypical bronchiolar epithelial hyperplasia. Benign. (M- 8040/1). http://purl.obolibrary.org/obo/MPATH_374 esthesioneuroblastoma http://purl.obolibrary.org/obo/MPATH_373 CNS progenitor tumor A neoplasm of immature, poorly differentiated neuronal cells believed to arise from neuroepithelial precursors in the olfactory epithelium. (M- 9522/3). http://purl.obolibrary.org/obo/MPATH_38 copper deposition http://purl.obolibrary.org/obo/MPATH_555 mineralisation Intra and extracellular deposition of copper and copper containing proteins. http://purl.obolibrary.org/obo/MPATH_380 ameloblastic fibroma http://purl.obolibrary.org/obo/MPATH_379 odontogenic tumor A tumor consisting of proliferating strands and clumps of odontogenic epithelium in a highly cellular fibroblastic stroma resembling the dental papilla of developing teeth. The epithelial component are composed of peripheral cuboidal or cylindrical cells enclosing scant stellate cells. (M-9330/0). http://purl.obolibrary.org/obo/MPATH_381 ameloblastoma http://purl.obolibrary.org/obo/MPATH_379 odontogenic tumor Benign odontogenic epithelial neoplasm that histologically mimics the embryonic enamel organ but does not differentiate to the point of forming dental hard tissue. Histologically dominated by epithelial cells in a scant fibroblastic stroma. (M-9310/0). http://purl.obolibrary.org/obo/MPATH_382 cementifying fibroma http://purl.obolibrary.org/obo/MPATH_379 odontogenic tumor Benign neoplasm derived from pluripotential mesenchymal cells or cementoblasts. Well demarcated tumor occurring exclusively in the jaw containing spindle cells which undergo transformation to cuboidal cementoblasts forming multiple cementicle like bodies. ( M-9274/0). http://purl.obolibrary.org/obo/MPATH_383 cementoblastoma http://purl.obolibrary.org/obo/MPATH_379 odontogenic tumor A neoplasm arising from the periodontal ligament (M-9273/0). http://purl.obolibrary.org/obo/MPATH_384 cementoma http://purl.obolibrary.org/obo/MPATH_379 odontogenic tumor Reactive fibro-osseous lesion derived from odotongenic cells in the periodontal ligament (M-9272/0). http://purl.obolibrary.org/obo/MPATH_385 dentinoma http://purl.obolibrary.org/obo/MPATH_379 odontogenic tumor Similar lesion to ameloblastic fibroma (MPATH380) , but also showing inductive changes that lead to the formation of dentine (M-9271/0). http://purl.obolibrary.org/obo/MPATH_389 chondroblastoma http://purl.obolibrary.org/obo/MPATH_388 osseous and chondromatous tumor A benign or malignant neoplasm occuring in the epiphyses of long bones, consisting of highly cellular tissue resembling embryonic cartilage. (M-9230/0, /3). http://purl.obolibrary.org/obo/MPATH_39 glycogen deposition http://purl.obolibrary.org/obo/MPATH_33 intracellular and extracellular accumulation Intracellular deposition of glycogen. http://purl.obolibrary.org/obo/MPATH_391 chondroma http://purl.obolibrary.org/obo/MPATH_388 osseous and chondromatous tumor A benign neoplasm derived from mesodermal cells that form cartilage composed of well differentiated hyaline cartilage (M-9220/0). http://purl.obolibrary.org/obo/MPATH_393 osteoblastoma http://purl.obolibrary.org/obo/MPATH_388 osseous and chondromatous tumor Generally benign osteogenic neoplasm of unknown aetiology. Aggressive form may be confused with osteosarcoma. NOT a syn for osteofibroma. (M-9200/0). http://purl.obolibrary.org/obo/MPATH_394 osteochondroma http://purl.obolibrary.org/obo/MPATH_388 osseous and chondromatous tumor Benign bone tumor characterized by hyaline cartilage capped bony growths that project from the surface of the affected bone. (M-9210/0). http://purl.obolibrary.org/obo/MPATH_395 osteofibroma http://purl.obolibrary.org/obo/MPATH_388 osseous and chondromatous tumor Benign neoplasm derived from pluripotential mesenchymal stem cells or osteoblasts composed of mature nbone trabelculae seperated by a stroma of spindle cells. (M- 9262/0). http://purl.obolibrary.org/obo/MPATH_399 aortic body tumor http://purl.obolibrary.org/obo/MPATH_398 paragangliomas and glomus tumor Paraganglioma arising in the CHIEF cells of the aortic body (M-8691/1). http://purl.obolibrary.org/obo/MPATH_40 hyalinosis http://purl.obolibrary.org/obo/MPATH_33 intracellular and extracellular accumulation Intracellular deposition of eosinophilic material. http://purl.obolibrary.org/obo/MPATH_400 carotid body tumor http://purl.obolibrary.org/obo/MPATH_398 paragangliomas and glomus tumor Paraganglioma arising in the CHIEF cells of the carotid body (M-8692/1). http://purl.obolibrary.org/obo/MPATH_401 glomus jugulare tumor http://purl.obolibrary.org/obo/MPATH_398 paragangliomas and glomus tumor A glomus tumor arising from the chief cells of the paraganglia ( neurectodermal derivatives) , or glomus bodies, located within the wall (adventitia) of the jugular bulb. (8690/1). http://purl.obolibrary.org/obo/MPATH_406 dermatofibrosarcoma http://purl.obolibrary.org/obo/MPATH_551 sarcoma Highly recurrent, infiltrative skin tumors of intermediate malignancy derived from fibroblasts/fibrocytes. Human condition dermatofibrosarcoma protruberans (M-8832/3). http://purl.obolibrary.org/obo/MPATH_409 fibrous histiocytoma http://purl.obolibrary.org/obo/MPATH_404 soft tissue tumor Benign or maligant tumor derived from pluripotential mesenchymal stem cells showing fibrous and histiocytic differentiation (M-8830/0). http://purl.obolibrary.org/obo/MPATH_41 iron deposition http://purl.obolibrary.org/obo/MPATH_555 mineralisation Extra- or intra-cellular deposition of iron, iron containing proteins or hemosiderin. http://purl.obolibrary.org/obo/MPATH_410 giant cell tumor of soft tissue http://purl.obolibrary.org/obo/MPATH_404 soft tissue tumor Malignant or benign tumor of pluripotential mesenchymal stem cells giving rise to large multinucleated cells (M- 9251/1). http://purl.obolibrary.org/obo/MPATH_412 alveolar soft part sarcoma http://purl.obolibrary.org/obo/MPATH_551 sarcoma Malignant tumor of unknown origin though probably myogenic due to expression of MyoD and other myogenic lineage markers. Consists of grouped polygonal tumor cells with granular eosinophilic cytoplasm arranged in an organ-like configuration separated by thin fibrovascular septa. Central areas within these nests of cells become necrotic, and the loss of architecture produces an alveolar appearance. (M-9581/3). http://purl.obolibrary.org/obo/MPATH_413 granular cell tumor http://purl.obolibrary.org/obo/MPATH_423 myomatous tumor Large polygonal or round cell tumors with abundant acidophilic cytoplasm containing PAS positive granules. Found especially in the uterine cervix. Aetiology unknown. (M-9580/0). http://purl.obolibrary.org/obo/MPATH_42 lipid deposition http://purl.obolibrary.org/obo/MPATH_33 intracellular and extracellular accumulation Extra or intracellular deposition of lipid. http://purl.obolibrary.org/obo/MPATH_421 lymphangiomyomatosis http://purl.obolibrary.org/obo/MPATH_419 lymphatic vessel tumor Characterized by benign peribronchial, perivascular, and perilymphatic proliferation of atypical smooth muscle resulting in vascular and airway obstruction, cyst formation, and a progressive decline in lung function. (M- 9174/1). http://purl.obolibrary.org/obo/MPATH_422 lymphangiosarcoma http://purl.obolibrary.org/obo/MPATH_551 sarcoma A malignant neoplasm derived from vascular tissue in which the neoplastic cells originate from the endothelial cells of lymphatic vessels. (M-9170/3). http://purl.obolibrary.org/obo/MPATH_424 intravascular leiomyomatosis http://purl.obolibrary.org/obo/MPATH_423 myomatous tumor Benign leiomyoma that invades vascular spaces. (M-8890/1). http://purl.obolibrary.org/obo/MPATH_43 lipofuscin deposition http://purl.obolibrary.org/obo/MPATH_613 pigmentation Intracellular deposition of brown pigment granules probably representing lipid-containing residues of lysosomal digestion. Often age related. http://purl.obolibrary.org/obo/MPATH_430 angiomyxoma http://purl.obolibrary.org/obo/MPATH_429 myxomatous tumor Angiomyxoma is a poorly circumscribed, slowly growing lesion composed of spindle-shaped and stellate cells evenly distributed in an abundant myxoid matrix. The lesion contains numerous vessels, often showing some hyalinization of their walls, and occasionally surrounded by a few smooth muscle cells. Immunohistochemically, tumor cells may express desmin and/ or smooth muscle actin (M-8841/1). http://purl.obolibrary.org/obo/MPATH_432 myxosarcoma http://purl.obolibrary.org/obo/MPATH_551 sarcoma A malignant neoplasm derived from pluripotential mesenchymal stem cells of connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix. (M-8840/3). http://purl.obolibrary.org/obo/MPATH_436 neurofibromatosis http://purl.obolibrary.org/obo/MPATH_433 nerve sheath tumor Systemic manifestation of MPATH:435 ( M-9540/1). http://purl.obolibrary.org/obo/MPATH_439 synovial-like tumor http://purl.obolibrary.org/obo/MPATH_404 soft tissue tumor Neoplasms of synovial origin. http://purl.obolibrary.org/obo/MPATH_44 melanin deposition http://purl.obolibrary.org/obo/MPATH_613 pigmentation Intra or extracellular deposition of melanin. http://purl.obolibrary.org/obo/MPATH_440 synovial sarcoma http://purl.obolibrary.org/obo/MPATH_551 sarcoma Malignant neoplasm occurring in close association with tendon sheaths and joint capsules. Biphasic in humans , showing a mixed spindle cell and epithelioid like morphology; this is not seen in rodents to date. (M-9040/3). http://purl.obolibrary.org/obo/MPATH_443 inverted squamous papilloma http://purl.obolibrary.org/obo/MPATH_445 papilloma A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells in which proliferating epithelium is invaginated beneath the surface and is more smoothly rounded. (M-8053/0). http://purl.obolibrary.org/obo/MPATH_444 keratoacanthoma http://purl.obolibrary.org/obo/MPATH_442 squamous cell tumor Skin type is thought to arise from follicular epithelium of hair follicles; found in other epithelia. Composed of multiple cup shaped cavities filled with lamellated concentrically arranged or homogeneous cornified masses. http://purl.obolibrary.org/obo/MPATH_447 squamous cell carcinoma in situ http://purl.obolibrary.org/obo/MPATH_556 potentially cancerous lesions Pre-neoplastic intraepithelial lesion of squamous cells (M-8070/2). http://purl.obolibrary.org/obo/MPATH_448 squamous cell papilloma http://purl.obolibrary.org/obo/MPATH_445 papilloma A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic squamous epithelial cells. http://purl.obolibrary.org/obo/MPATH_449 verrucous carcinoma http://purl.obolibrary.org/obo/MPATH_549 carcinoma A well-differentiated papillary squamous cell carcinoma. (M-8051/3). http://purl.obolibrary.org/obo/MPATH_45 protein deposition http://purl.obolibrary.org/obo/MPATH_33 intracellular and extracellular accumulation Non-specified intra or extracellular deposition of protein. http://purl.obolibrary.org/obo/MPATH_452 transitional cell carcinoma in situ http://purl.obolibrary.org/obo/MPATH_556 potentially cancerous lesions Pre-malignant intra-epithelial neoplasm of transitional cells (M-8120/2). http://purl.obolibrary.org/obo/MPATH_453 transitional cell papilloma http://purl.obolibrary.org/obo/MPATH_450 transitional cell tumor Pre-malignant lesion of transitional cells, papillomatous form ( M- 8120/1). http://purl.obolibrary.org/obo/MPATH_454 trophoblastic tumor http://purl.obolibrary.org/obo/MPATH_218 neoplasm Tumors derived directly from trophoblastic tissue or differentiated from germ cell tumor origins. http://purl.obolibrary.org/obo/MPATH_455 choriocarcinoma http://purl.obolibrary.org/obo/MPATH_310 germ cell tumor Tumor derived from malignant trophoblastic cells. May be found in the uterus, ovary and testis. May also be derived from teratomas and teratocarcinomas in males. (M-9100/3). http://purl.obolibrary.org/obo/MPATH_456 hydatidiform mole http://purl.obolibrary.org/obo/MPATH_454 trophoblastic tumor Vesicular or cystic tumor with hydropic villi resulting from the proliferation of trophoblast in the absence ( complete) or the presence ( partial) of an embryo. Most complete moles are homozygous androgenetic XX 46.(M-9100/0). http://purl.obolibrary.org/obo/MPATH_457 placental site trophoblastic tumor http://purl.obolibrary.org/obo/MPATH_454 trophoblastic tumor Neoplastic proliferation of intermediate trophoblasts that invades the myometrium at the placental site after a pregnancy. (M-9104/1). http://purl.obolibrary.org/obo/MPATH_458 normal http://purl.obolibrary.org/obo/MPATH_1000 pathological phenotype observation No pathological entity observable. http://purl.obolibrary.org/obo/MPATH_46 uric acid deposition http://purl.obolibrary.org/obo/MPATH_33 intracellular and extracellular accumulation Extracellular deposition of uric acid crystals. http://purl.obolibrary.org/obo/MPATH_460 nuclear defect http://purl.obolibrary.org/obo/MPATH_17 subcellular defect Defect in the structure or function of the nuclear membrane or matrix or other component. http://purl.obolibrary.org/obo/MPATH_461 cataract; capsular-epithelial http://purl.obolibrary.org/obo/MPATH_29 cataract Proliferation of lens epithelium and capsule leading to fibrous metaplasia and anterior subcapsular cataract ( ASC) . Possible developmental origin. http://purl.obolibrary.org/obo/MPATH_462 cataract; nuclear and cortical http://purl.obolibrary.org/obo/MPATH_29 cataract Nuclear cataract of developmental origin with tendency to progress with age and involve the cortex and capsule. http://purl.obolibrary.org/obo/MPATH_463 cataract; cortical liquefactive http://purl.obolibrary.org/obo/MPATH_29 cataract Of developmental origins; nucleus and cortex become completely liquefied in post-natal life. http://purl.obolibrary.org/obo/MPATH_464 cataract; lens extrusion http://purl.obolibrary.org/obo/MPATH_29 cataract Involves capsular rupture usually of the posterior lens capsule, close to birth or in the first few weeks postpartum. Cortical material spills into the vitreous humor and may be disseminated through the eye. http://purl.obolibrary.org/obo/MPATH_465 glaucoma developmental http://purl.obolibrary.org/obo/MPATH_32 glaucoma Consequent on developmental abnormalities in the trabecular network and Schlemm`s canal in the angle. http://purl.obolibrary.org/obo/MPATH_466 glaucoma; open angle http://purl.obolibrary.org/obo/MPATH_32 glaucoma Failure of drainage of the eye for unknown reasons. http://purl.obolibrary.org/obo/MPATH_467 glaucoma; angle closure http://purl.obolibrary.org/obo/MPATH_32 glaucoma Develops when the angle caused by the iris and cornea closes. May occur because of anatomically narrow angles or adhesions. http://purl.obolibrary.org/obo/MPATH_468 pseudocyst http://purl.obolibrary.org/obo/MPATH_1 cell and tissue damage Formation of extracellular (sensu pancreas) non-epithelial bounded spaces containing accumulated products or substances. http://purl.obolibrary.org/obo/MPATH_469 symmetry defect http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect Any aberration of the normal symmetrical organisation of the body pattern. http://purl.obolibrary.org/obo/MPATH_47 intracellular and extracellular depletion http://purl.obolibrary.org/obo/MPATH_1 cell and tissue damage Loss or dispersion of specific intra- and extracellular substances. http://purl.obolibrary.org/obo/MPATH_470 left/right axis defect http://purl.obolibrary.org/obo/MPATH_469 symmetry defect Left/Right (mediolateral) axis aberration of the normal symmetrical organisation of the body pattern. http://purl.obolibrary.org/obo/MPATH_471 anterior/posterior axis defect http://purl.obolibrary.org/obo/MPATH_469 symmetry defect Anteroposterior aberration of the normal symmetrical organisation of the body pattern. http://purl.obolibrary.org/obo/MPATH_472 dorsal/ventral axis defect http://purl.obolibrary.org/obo/MPATH_469 symmetry defect Dorsoventral aberration of the normal symmetrical organisation of the body pattern. http://purl.obolibrary.org/obo/MPATH_473 developmental cystic dysplasia http://purl.obolibrary.org/obo/MPATH_64 developmental dysplasia Developmental dysplasia showing epithelial cell bounded cavities. http://purl.obolibrary.org/obo/MPATH_475 ductal ectasia http://purl.obolibrary.org/obo/MPATH_474 ectasia Dilation of a ductal structure. http://purl.obolibrary.org/obo/MPATH_477 choristoma http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect Similar to hamartoma, including the mass lesion requirement, but unlike hamartoma, includes heterotopic tissue of an adult or embryonic nature ( topographical and developmental anomaly). http://purl.obolibrary.org/obo/MPATH_478 angiogenesis defect http://purl.obolibrary.org/obo/MPATH_599 developmental process abnormalities Abnormality in developmental angiogenesis. http://purl.obolibrary.org/obo/MPATH_479 vasculogenesis defect http://purl.obolibrary.org/obo/MPATH_599 developmental process abnormalities Defect in formation of blood vessels by vasculogenesis, proliferation or recruitment of endothelial cells. http://purl.obolibrary.org/obo/MPATH_48 decalcification http://purl.obolibrary.org/obo/MPATH_47 intracellular and extracellular depletion Process of loss of calcium from normally calcified tissue, usually bone. http://purl.obolibrary.org/obo/MPATH_480 decidual defect http://purl.obolibrary.org/obo/MPATH_100 placental abnormality Any defect in the formation, architecture, cellular composition or function of the maternal decidua. http://purl.obolibrary.org/obo/MPATH_482 focal hyperplasia http://purl.obolibrary.org/obo/MPATH_602 hyperplastic tissue Localised hyperplastic lesion. Polyclonal lesions are probably benign but clonal lesions may progress to malignancy. http://purl.obolibrary.org/obo/MPATH_484 hyperplastic nodule http://purl.obolibrary.org/obo/MPATH_602 hyperplastic tissue Expansion of small hyperplastic lesions to become macroscopically nodules, compressing adjacent cells. http://purl.obolibrary.org/obo/MPATH_486 ductal intra-epithelial neoplasia http://purl.obolibrary.org/obo/MPATH_556 potentially cancerous lesions Pre-malignant hyperplastic and/or dysplastic change in the mammary gland epithelium with the potential to give rise to malignant tumors. http://purl.obolibrary.org/obo/MPATH_487 intestinal intra-epithelial neoplasia http://purl.obolibrary.org/obo/MPATH_128 intra-epithelial neoplasia Histologically apparent areas of dysplasia that are not grossly visible (smaller than 0.5-1 mm). Lesions may involve single or multiple glands. http://purl.obolibrary.org/obo/MPATH_488 prostate intra-epithelial neoplasia http://purl.obolibrary.org/obo/MPATH_128 intra-epithelial neoplasia See reference for definition. http://purl.obolibrary.org/obo/MPATH_489 stomach, oesophagus and pancreatic intra-epithelial neoplasia http://purl.obolibrary.org/obo/MPATH_128 intra-epithelial neoplasia stomach, oesophagus and pancreatic intra-epithelial neoplasia http://purl.obolibrary.org/obo/MPATH_49 demyelination http://purl.obolibrary.org/obo/MPATH_47 intracellular and extracellular depletion Reduction of myelin content in neuronal sheath. http://purl.obolibrary.org/obo/MPATH_491 polyp http://purl.obolibrary.org/obo/MPATH_138 epithelial hyperplasia A mass of tissue which projects outward or upward from the normal surface level being macroscopically visible as a hemispheroidal, spheroidal, or irregular moundlike structure growing from a relatively broad base or a slender stalk. http://purl.obolibrary.org/obo/MPATH_492 membraneous glomerulonephritis http://purl.obolibrary.org/obo/MPATH_197 glomerulonephritis Glomerulonephritis characterized by diffuse thickening of glomerular capillary basement membranes, due in part to subepithelial deposits of immunoglobulins separated by spikes of basement membrane material,. http://purl.obolibrary.org/obo/MPATH_493 membraneoproliferative glomerulonephritis http://purl.obolibrary.org/obo/MPATH_197 glomerulonephritis A chronic glomerulonephritis characterized by mesangial cell proliferation, increased lobular separation of glomeruli, thickening of glomerular capillary walls and increased mesangial matrix,. http://purl.obolibrary.org/obo/MPATH_494 autoimmune glomerulonephritis http://purl.obolibrary.org/obo/MPATH_197 glomerulonephritis Glomerulonephritis caused by autoimmune attack on the glomerulus. http://purl.obolibrary.org/obo/MPATH_495 glomangioma http://purl.obolibrary.org/obo/MPATH_235 blood vessel tumor Tumor derived from the capillary glomus with arteriovenous capillary anastomoses. Often characterized by multiple tumors resembling cavernous hemangioma (M-8712/0). http://purl.obolibrary.org/obo/MPATH_497 myeloid leukaemia without maturation http://purl.obolibrary.org/obo/MPATH_342 myeloid leukaemia Leukaemia in which neoplastic cells are poorly differentiated and not monocytic. At least 90% of the cells have to be blasts. http://purl.obolibrary.org/obo/MPATH_498 myeloid leukaemia with maturation http://purl.obolibrary.org/obo/MPATH_342 myeloid leukaemia Leukaemia in which neoplastic cells are moderately differentiated with a neutrophilic but not monocytic component. At least 20% of the cells have to be blasts. http://purl.obolibrary.org/obo/MPATH_499 nesidioblastosis http://purl.obolibrary.org/obo/MPATH_64 developmental dysplasia Abnormal proliferation of beta cells of developing islets often leading to marked diffuse or focal beta-cell hyperplasia. Considered to generate a potentially cancerous lesion. http://purl.obolibrary.org/obo/MPATH_5 bridging necrosis http://purl.obolibrary.org/obo/MPATH_4 necrosis Area of liver necrosis that bridges adjacent portal areas and central veins. http://purl.obolibrary.org/obo/MPATH_50 glycogen depletion http://purl.obolibrary.org/obo/MPATH_47 intracellular and extracellular depletion Reduction in intracellular glycogen content. http://purl.obolibrary.org/obo/MPATH_500 myeloproliferative disease-like myeloid leukaemia http://purl.obolibrary.org/obo/MPATH_342 myeloid leukaemia Leukaemia in which neoplastic cells are well differentiated and in which there are fewer than 20% blasts. http://purl.obolibrary.org/obo/MPATH_501 myelomonocytic leukaemia http://purl.obolibrary.org/obo/MPATH_342 myeloid leukaemia Leukaemia in which neoplastic cells are moderately differentiated with a neutrophilic and a monocytic component. At least 20% of the cells have to be blasts. http://purl.obolibrary.org/obo/MPATH_503 biphenotypic leukaemia http://purl.obolibrary.org/obo/MPATH_496 Non-Lymphoid leukaemias A leukaemia with at least 90% blasts and differentiation markers of the myeloid and lymphoid lineage. http://purl.obolibrary.org/obo/MPATH_505 granulocytic sarcoma http://purl.obolibrary.org/obo/MPATH_504 non-lymphoid hematopoietic sarcomas Solid tumor mass composed predominantly of granulocytic or relatively undifferentiated non-lymphoid haematopoietic cells. http://purl.obolibrary.org/obo/MPATH_507 mast cell sarcoma http://purl.obolibrary.org/obo/MPATH_504 non-lymphoid hematopoietic sarcomas Solid tumor mass composed of mast cells. http://purl.obolibrary.org/obo/MPATH_508 myeloid dysplasias http://purl.obolibrary.org/obo/MPATH_515 non-Lymphoid neoplasias Haematopoietic proliferation with evidence of trilineage dysplasia. http://purl.obolibrary.org/obo/MPATH_509 cytopenia with increased blasts http://purl.obolibrary.org/obo/MPATH_508 myeloid dysplasias Haematopoietic proliferation with evidence of trilineage dysplasia. More than 20% should be blasts. http://purl.obolibrary.org/obo/MPATH_51 hypocalcification http://purl.obolibrary.org/obo/MPATH_47 intracellular and extracellular depletion Intrinsic abnormally low level of calcification in a tissue cf. MPATH: 48. http://purl.obolibrary.org/obo/MPATH_510 myeloid proliferations (non-reactive) http://purl.obolibrary.org/obo/MPATH_515 non-Lymphoid neoplasias Non-reactive persistent accumulation of non-lymphoid haematopoietic cells. Genetically determined. http://purl.obolibrary.org/obo/MPATH_511 myeloproliferation (genetic) http://purl.obolibrary.org/obo/MPATH_510 myeloid proliferations (non-reactive) Non-reactive persistent accumulation of non-lymphoid haematopoietic cells in the blood which do not infiltrate the spleen and the bone marrow. Genetically determined. http://purl.obolibrary.org/obo/MPATH_512 myeloproliferative disease http://purl.obolibrary.org/obo/MPATH_510 myeloid proliferations (non-reactive) Non-reactive persistent accumulation of non-lymphoid haematopoietic cells in the blood which infiltrate the spleen and the bone marrow. http://purl.obolibrary.org/obo/MPATH_517 precursor B cell neoplasms http://purl.obolibrary.org/obo/MPATH_516 B-cell neoplasms Lymphoma originating from precursor B-cells. http://purl.obolibrary.org/obo/MPATH_518 precursor B -cell lymphoblastic lymphoma/leukaemia http://purl.obolibrary.org/obo/MPATH_517 precursor B cell neoplasms Lymphoma originating in a precursor B-cell. http://purl.obolibrary.org/obo/MPATH_52 lipid depletion http://purl.obolibrary.org/obo/MPATH_47 intracellular and extracellular depletion Reduction in cellular or plasma lipid content. http://purl.obolibrary.org/obo/MPATH_520 small B-cell lymphoma http://purl.obolibrary.org/obo/MPATH_519 mature B-cell neoplasms Diffuse accumulation of small mature B-cells. http://purl.obolibrary.org/obo/MPATH_521 splenic marginal zone lymphoma http://purl.obolibrary.org/obo/MPATH_519 mature B-cell neoplasms A lymphoid proliferation of cells of the marginal zone of the white pulp of the spleen. http://purl.obolibrary.org/obo/MPATH_522 follicular B cell lymphoma http://purl.obolibrary.org/obo/MPATH_519 mature B-cell neoplasms A lymphoid proliferation composed of a mixture of centroblasts and centrocytes that may or may not have a nodular(follicular)pattern. The follicular dendritic cell network is not present, unlike in the human. The equivalent typical translocation (Chr. 14:18 )seen in humans has not been reported in the mouse. http://purl.obolibrary.org/obo/MPATH_523 diffuse large B-cell lymphoma http://purl.obolibrary.org/obo/MPATH_519 mature B-cell neoplasms Diffuse proliferation of large B lymphoid cells. http://purl.obolibrary.org/obo/MPATH_524 diffuse large B-cell lymphoma, centroblastic type http://purl.obolibrary.org/obo/MPATH_523 diffuse large B-cell lymphoma Diffuse follicular centre cell lymphoma mainly composed of centroblasts. http://purl.obolibrary.org/obo/MPATH_525 diffuse large B-cell lymphoma, immunoblastic type http://purl.obolibrary.org/obo/MPATH_523 diffuse large B-cell lymphoma Diffuse large B cell lymphoma with increased number of immunoblasts. http://purl.obolibrary.org/obo/MPATH_526 diffuse large B-cell lymphoma, histiocyte associated http://purl.obolibrary.org/obo/MPATH_523 diffuse large B-cell lymphoma Diffuse large B-cell lymphoma with more than 50% histiocytes. http://purl.obolibrary.org/obo/MPATH_527 primary mediastinal (thymic) diffuse large B cell lymphoma http://purl.obolibrary.org/obo/MPATH_523 diffuse large B-cell lymphoma Primary B-cell lymphoma of the thymus. Reported in C57BL/6 mice infected with replication defective MuLV. Not clear that this is the equivalent of the human disease. http://purl.obolibrary.org/obo/MPATH_528 classic Burkitt lymphoma http://purl.obolibrary.org/obo/MPATH_519 mature B-cell neoplasms Highly proliferative B-cell lymphoma characteristically seen in c-Myc transgenic mice, derived from mature B cells. http://purl.obolibrary.org/obo/MPATH_529 Burkitt-like lymphoma http://purl.obolibrary.org/obo/MPATH_519 mature B-cell neoplasms Highly proliferative mature B-cell lymphoma, poorly defined. http://purl.obolibrary.org/obo/MPATH_53 osteopenia http://purl.obolibrary.org/obo/MPATH_47 intracellular and extracellular depletion Reduced bone mass due to inadequate synthesis of osteoid, resulting in decreased calcification. http://purl.obolibrary.org/obo/MPATH_531 B-natural killer cell lymphoma http://purl.obolibrary.org/obo/MPATH_516 B-cell neoplasms Unusual lymphoma type described in thymectomised (SL/Kh x AKR/Ms) F1 mice. No equivalent found in human to date. See reference for detailed phenotype. http://purl.obolibrary.org/obo/MPATH_533 extraosseous plasmacytoma http://purl.obolibrary.org/obo/MPATH_532 plasmacytoma Diffuse proliferation of mature plasma cells. Clonal by definition. Frequently found in IL6 transgenic mice. Characteristically involves spleen and nodes rather than peritoneum. http://purl.obolibrary.org/obo/MPATH_538 mature T-cell neoplasms http://purl.obolibrary.org/obo/MPATH_535 T-cell neoplasms Non-thymic neoplasms of mature T cell origin. http://purl.obolibrary.org/obo/MPATH_539 small T-cell lymphoma http://purl.obolibrary.org/obo/MPATH_538 mature T-cell neoplasms Accumulation of small mature T cells. No human counterpart known to date. http://purl.obolibrary.org/obo/MPATH_54 osteoporosis http://purl.obolibrary.org/obo/MPATH_47 intracellular and extracellular depletion Reduction in the quantity of bone or atrophy of skeletal tissue. More severe than MPATH: 53 with gross changes to bone matrix. http://purl.obolibrary.org/obo/MPATH_540 T cell neoplasms character undetermined http://purl.obolibrary.org/obo/MPATH_535 T-cell neoplasms T cell neoplasms which cannot currently be classified into known subtypes. http://purl.obolibrary.org/obo/MPATH_541 T large cell anaplastic lymphoma http://purl.obolibrary.org/obo/MPATH_540 T cell neoplasms character undetermined Diffuse large pleiomorphic T cell lymphoma. This entity does not correspond to human anaplastic large cell lymphoma. http://purl.obolibrary.org/obo/MPATH_542 T natural killer cell lymphoma http://purl.obolibrary.org/obo/MPATH_535 T-cell neoplasms Neoplasm of large granular T cells of CD8 phenotype. http://purl.obolibrary.org/obo/MPATH_543 cholangioma http://purl.obolibrary.org/obo/MPATH_352 hepatic tumor Benign neoplasm of the biliary duct. Occurs in solid and cystic forms. (M-8160/0). http://purl.obolibrary.org/obo/MPATH_544 hepatocholangiocellular adenoma http://purl.obolibrary.org/obo/MPATH_352 hepatic tumor Benign tumor of unknown origin showing features of hepatocelluar adenoma and cholangioma. http://purl.obolibrary.org/obo/MPATH_545 hepatocholangiocellular carcinoma http://purl.obolibrary.org/obo/MPATH_549 carcinoma Malignant tumor of unknown origin showing features of hepatocelluar carcinoma and cholangiocarcinoma. (M-8180/3). http://purl.obolibrary.org/obo/MPATH_547 mucous secretions http://purl.obolibrary.org/obo/MPATH_33 intracellular and extracellular accumulation Extracellular accumulation of mucous secretions. http://purl.obolibrary.org/obo/MPATH_548 papillary transitional cell carcinoma http://purl.obolibrary.org/obo/MPATH_450 transitional cell tumor A generally malignant neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by atypical neoplastic epithelial or urothelial cells cells. http://purl.obolibrary.org/obo/MPATH_553 neuritis http://purl.obolibrary.org/obo/MPATH_212 inflammation Inflammation of a nerve. http://purl.obolibrary.org/obo/MPATH_554 dystrophy http://purl.obolibrary.org/obo/MPATH_14 process of degenerative change Regressive changes which may increase in severity, and which may result from defective nutrition or support of a tissue or organ. http://purl.obolibrary.org/obo/MPATH_558 adenomyoepithelioma http://purl.obolibrary.org/obo/MPATH_254 complex tumor Adenocarcinoma type tumor with both glandular and squamous differentiation. (M-8983/0). http://purl.obolibrary.org/obo/MPATH_559 acinar adenocarcinoma http://purl.obolibrary.org/obo/MPATH_268 adenocarcinoma Tumor composed of small glandular clusters with small lumens. http://purl.obolibrary.org/obo/MPATH_560 cribriform adenocarcinoma http://purl.obolibrary.org/obo/MPATH_268 adenocarcinoma Tumor composed of sheets or nests of cells forming lumens with round, punched out spaces. http://purl.obolibrary.org/obo/MPATH_561 adenosquamous carcinoma http://purl.obolibrary.org/obo/MPATH_442 squamous cell tumor Mixed adeno- and squamous cell carcinoma. Not yet reported in mice. M-8560/3. http://purl.obolibrary.org/obo/MPATH_562 torsion http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect The twisting of a bodily organ or part on its own axis. http://purl.obolibrary.org/obo/MPATH_563 mucinous carcinoma http://purl.obolibrary.org/obo/MPATH_268 adenocarcinoma carcinoma derived from gastrointestinal epithelium with a high mucinous content. (M-8480/3). http://purl.obolibrary.org/obo/MPATH_567 pilocytic astrocytoma http://purl.obolibrary.org/obo/MPATH_244 astrocytoma Glial cell derived tumor composed of bipolar cells with long `hairlike` GFAP-positive processes. (M9421/1). http://purl.obolibrary.org/obo/MPATH_568 mixed glioma http://purl.obolibrary.org/obo/MPATH_249 glioma Mixed tumor containing astrocytes within an oligodendroglioma or vice versa. In some cases both components may be neoplastic. (M-9382/3). http://purl.obolibrary.org/obo/MPATH_57 agenesis http://purl.obolibrary.org/obo/MPATH_599 developmental process abnormalities Failure of a tissue or organ to develop. http://purl.obolibrary.org/obo/MPATH_572 ossifying fibroma http://purl.obolibrary.org/obo/MPATH_388 osseous and chondromatous tumor Ossifying fibromas are benign tumors derived from pluripotential mesenchymal stem cells or osteoblasts. Occur spontaneously or in response to radiation. Preferentially located in mandible, maxilla and caudal spine. Composed of a characteristically regular trabecular bone pattern embedded in a fibrous stroma. Proliferating component consists of spindle cells which give rise to cuboidal osteoblasts to form rounded bodies or trabeculae. Bone trabeculae resemble the alphabet soup shapes characteristic of fibrous dysplasia in humans. In contrast to fibrous dysplasia the bone trabeculae of ossifying fibroma are mostly lamellar and ringed by active osteoblasts. http://purl.obolibrary.org/obo/MPATH_573 inverted transitional cell papilloma http://purl.obolibrary.org/obo/MPATH_453 transitional cell papilloma Pre-malignant lesion of transitional cells, papillomatous form, in which proliferating epithelium is invaginated beneath the surface. http://purl.obolibrary.org/obo/MPATH_577 spiradenoma http://purl.obolibrary.org/obo/MPATH_575 basaloid follicular neoplasms Cellular neoplasm with well formed palisades of basaloid cells adjacent to less basophilic smaller cells with occasional central deposition of amorphous eosinophilic material. These tumors share some features with cylindroma type tumors but have a less well developed jigsaw puzzle-like architecture and tend to be more cellular. http://purl.obolibrary.org/obo/MPATH_578 trichoblastoma http://purl.obolibrary.org/obo/MPATH_575 basaloid follicular neoplasms Basaloid neoplasm with frequent primitive hair follicles. http://purl.obolibrary.org/obo/MPATH_58 aplasia http://purl.obolibrary.org/obo/MPATH_599 developmental process abnormalities Absence of an organ or tissue coupled with persistence of the organ/tissue primordium, which fails to develop completely. http://purl.obolibrary.org/obo/MPATH_580 erosion http://purl.obolibrary.org/obo/MPATH_15 general degenerative process Partial epithelial denudation not penetrating to the basement membrane. http://purl.obolibrary.org/obo/MPATH_581 desmoplasia http://purl.obolibrary.org/obo/MPATH_604 defective growth and differentiation process Connective tissue proliferative reaction induced by a neoplastic process. http://purl.obolibrary.org/obo/MPATH_582 cicatricial alopecia http://purl.obolibrary.org/obo/MPATH_26 alopecia Scarring of the hair follicle without affecting the adjacent dermis. Pigment may be associated with fibrous tract in pigmented individuals. http://purl.obolibrary.org/obo/MPATH_583 scarring alopecia http://purl.obolibrary.org/obo/MPATH_26 alopecia Loss of hair follicles in a diffuse dermal scar. http://purl.obolibrary.org/obo/MPATH_584 myelofibrosis http://purl.obolibrary.org/obo/MPATH_25 tissue specific degenerative process In mice the term refers to accumulation of fibrous connective tissue in the medullary cavity of bones; usually in old mice. In humans the term is synonymous with myeloid metaplasia. http://purl.obolibrary.org/obo/MPATH_585 acidophilic macrophage pneumonia http://purl.obolibrary.org/obo/MPATH_877 pneumonia A mixed inflammatory infiltrate in the pulmonary airways with predominant intra-alveolar macrophage component with intra- and extracellular, elongated, bright eosinophilic/acidophilic crystals. http://purl.obolibrary.org/obo/MPATH_586 polycystic disease http://purl.obolibrary.org/obo/MPATH_25 tissue specific degenerative process A group of degenerative disorders resulting in multiple cysts in tissues. http://purl.obolibrary.org/obo/MPATH_587 Cribriform epididymal hyperplasia http://purl.obolibrary.org/obo/MPATH_602 hyperplastic tissue The lesion is characterized microscopically by epithelial cells with atypical hyperchromatic nuclei, vacuolization, intratubular lumina formation, infrequent apoptosis, and rare mitotic figures. In contrast to germ cells, the cells of CEH do not express alpha-fetoprotein, carcinoembryonic antigen, or S-100. Ultrastructurally, the cells are pleomorphic with stereocilia at their apical borders and within intratubular lumina, and are supported by a basement membrane. CEH does not appear to be a preneoplastic change. http://purl.obolibrary.org/obo/MPATH_589 dysplasia http://purl.obolibrary.org/obo/MPATH_604 defective growth and differentiation process Distortion or deficiency of the tissue or cellular architecture. http://purl.obolibrary.org/obo/MPATH_59 defective branching morphogenesis http://purl.obolibrary.org/obo/MPATH_599 developmental process abnormalities Defect in the process determining number, angle, pattern or rate of branching of tubular branched structures eg. Glandular ducts. http://purl.obolibrary.org/obo/MPATH_590 fibro-osseous lesion http://purl.obolibrary.org/obo/MPATH_589 dysplasia Lesion of bone showing accelerated osteoclastic bone resorption coupled with fibroplasia. Later stages show proliferation of osteoblasts. http://purl.obolibrary.org/obo/MPATH_591 fatty infiltration http://purl.obolibrary.org/obo/MPATH_607 healing and repair structure Accumulation of mature adipose tissue in a healing wound site or otherwise in response to tissue damage. http://purl.obolibrary.org/obo/MPATH_592 osteopetrosis http://purl.obolibrary.org/obo/MPATH_589 dysplasia Excessive formation of dense trabecular bone and mineralized cartilage, especially in long bones, leading to obliteration of marrow spaces and to anemia with myeloid metaplasia and hepatosplenomegaly beginning in infancy, to bone fragility, and to progressive deafness and blindness. http://purl.obolibrary.org/obo/MPATH_594 cystic hyperplasia http://purl.obolibrary.org/obo/MPATH_135 epithelial and stromal hyperplasia Formation of multiple retention cysts from obstruction of ducts or glands by hyperplasia of the lining epithelium. http://purl.obolibrary.org/obo/MPATH_595 extramedullary hemopoiesis http://purl.obolibrary.org/obo/MPATH_515 non-Lymphoid neoplasias The formation of and development of blood cells outside the red pulp of the spleen. Composed of varying numbers of megakaryocytes as well as myeloid and erythroid precursors. http://purl.obolibrary.org/obo/MPATH_6 caseous necrosis http://purl.obolibrary.org/obo/MPATH_4 necrosis Necrosis characteristic of some inflammatory conditions which represents necrosis with loss of structure of the various cellular and tissue elements; affected tissue manifests a friable, crumbly consistency. http://purl.obolibrary.org/obo/MPATH_60 communication defect http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect Failure of two cavities, voids or lumens to connect. http://purl.obolibrary.org/obo/MPATH_600 branching defect http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect Aberrant branch or branching pattern of a branched structure such as the bronchus. http://purl.obolibrary.org/obo/MPATH_601 developmental hypertrophy http://purl.obolibrary.org/obo/MPATH_599 developmental process abnormalities Increase of the size or cellularity of an organ or tissue as a consequence of loss of normal regulation of cell proliferation. http://purl.obolibrary.org/obo/MPATH_606 neoplasia http://purl.obolibrary.org/obo/MPATH_596 pathological process The pathological process that results in the formation and growth of a neoplasm. http://purl.obolibrary.org/obo/MPATH_609 empyema http://purl.obolibrary.org/obo/MPATH_607 healing and repair structure Pus in a body cavity; when used without qualification, refers specifically to pyothorax. http://purl.obolibrary.org/obo/MPATH_61 curvature defect http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect Inappropriate curvature of a structure. http://purl.obolibrary.org/obo/MPATH_610 angiectasia http://purl.obolibrary.org/obo/MPATH_474 ectasia Dilatation of a blood vessel or valve. http://purl.obolibrary.org/obo/MPATH_611 glossitis http://purl.obolibrary.org/obo/MPATH_212 inflammation Acute or chronic inflammation of the tongue. http://purl.obolibrary.org/obo/MPATH_613 pigmentation http://purl.obolibrary.org/obo/MPATH_33 intracellular and extracellular accumulation Coloration, either normal or pathologic, of the skin or tissues resulting from a deposit of pigment. http://purl.obolibrary.org/obo/MPATH_614 concretion http://purl.obolibrary.org/obo/MPATH_33 intracellular and extracellular accumulation Solid material formed by aggregation of discrete units or particles. http://purl.obolibrary.org/obo/MPATH_616 hyperostosis http://purl.obolibrary.org/obo/MPATH_159 hypertrophy Hypertrophy of bone characterised by an abnormal increase in non-neoplastic skeletal bone mass. These may be proliferative or non-proliferative lesions. http://purl.obolibrary.org/obo/MPATH_617 focus of cellular alteration http://purl.obolibrary.org/obo/MPATH_556 potentially cancerous lesions Focal lesions of hepatocytes characterised primarily by altered cytoplasmic tinctorial properties. Classified as basophilic, eosinophilic, clear cell or mixed type. http://purl.obolibrary.org/obo/MPATH_618 myeloid hyperplasia http://purl.obolibrary.org/obo/MPATH_515 non-Lymphoid neoplasias Hyperplasia of myeloid lineage, usually in the spleen. http://purl.obolibrary.org/obo/MPATH_619 truncoconal septal defect http://purl.obolibrary.org/obo/MPATH_93 cardiac septation defect Septal defect lying between the aorta and pulmonary trunks caused by failure of the spiral septum to separate the truncus arteriosus. http://purl.obolibrary.org/obo/MPATH_620 inter-atrial septal defect http://purl.obolibrary.org/obo/MPATH_93 cardiac septation defect Incomplete closure of the inter-atrial septum due to failure of the primary or secondary septum. http://purl.obolibrary.org/obo/MPATH_621 inter-ventricular septal defect http://purl.obolibrary.org/obo/MPATH_93 cardiac septation defect Failure of the inter-ventricular septum to completely close between the left and right ventricles. http://purl.obolibrary.org/obo/MPATH_623 synechia http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect An adhesion, usually between the iris and the cornea or the lens capsule. http://purl.obolibrary.org/obo/MPATH_624 involution http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect Turning in of the edges of a structure. http://purl.obolibrary.org/obo/MPATH_626 prolapse http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect To sink down, said of an organ or other part. A sinking of an organ or other part, especially its appearance at a natural or artificial orifice. http://purl.obolibrary.org/obo/MPATH_627 pyogranulomatous inflammation http://purl.obolibrary.org/obo/MPATH_215 granulomatous inflammation An inflammatory process in which there is infiltration of polymorphonuclear cells into a more chronic area of inflammation characterized by mononuclear cells, macrophages, lymphocytes and possibly plasma cells. http://purl.obolibrary.org/obo/MPATH_628 pyogenic granuloma http://purl.obolibrary.org/obo/MPATH_240 hemangioma A small rounded mass of inflamed, highly vascular granulation tissue on the skin, frequently having an ulcerated surface. More likely a true neoplasm rather than a reactive lesion. http://purl.obolibrary.org/obo/MPATH_63 depletion http://purl.obolibrary.org/obo/MPATH_599 developmental process abnormalities The removal of accumulated fluids or solids. http://purl.obolibrary.org/obo/MPATH_630 karyomegaly http://purl.obolibrary.org/obo/MPATH_460 nuclear defect Abnormally increased nuclear size. http://purl.obolibrary.org/obo/MPATH_631 hypertrophic tissue http://purl.obolibrary.org/obo/MPATH_126 growth and differentiation defect Tissue or cells undergoing hypertrophy, MPATH: 159. http://purl.obolibrary.org/obo/MPATH_632 hepatocytomegaly http://purl.obolibrary.org/obo/MPATH_631 hypertrophic tissue Increase in size of hepatocytes characterised by organelle hyperplasia and enlarged cellular volume. http://purl.obolibrary.org/obo/MPATH_633 cholelithiasis http://purl.obolibrary.org/obo/MPATH_614 concretion Presence of concretions in the gallbladder or bile ducts. http://purl.obolibrary.org/obo/MPATH_634 furunculosis http://purl.obolibrary.org/obo/MPATH_212 inflammation Focal suppurative inflammation of the skin and subcutaneous tissues, enclosing a central slough or `core`. http://purl.obolibrary.org/obo/MPATH_635 hydronephrosis http://purl.obolibrary.org/obo/MPATH_708 pyelectasia Swelling of the kidneys when urine flow is obstructed in any of part of the urinary tract. Severe form of pyelectasia. http://purl.obolibrary.org/obo/MPATH_636 steatitis http://purl.obolibrary.org/obo/MPATH_212 inflammation Inflammation of fatty tissue. http://purl.obolibrary.org/obo/MPATH_637 bursal cyst http://purl.obolibrary.org/obo/MPATH_62 cyst A retention cyst, resulting from an obstruction to the duct of a gland, within a bursa. http://purl.obolibrary.org/obo/MPATH_638 cellulitis http://purl.obolibrary.org/obo/MPATH_212 inflammation An acute, diffuse, spreading, edematous, suppurative inflammation of the deep subcutaneous tissues and sometimes muscle, which may be associated with abscess formation. http://purl.obolibrary.org/obo/MPATH_639 hydrocephalus http://purl.obolibrary.org/obo/MPATH_33 intracellular and extracellular accumulation Accumulation of water in the ventricles of the brain. http://purl.obolibrary.org/obo/MPATH_640 osteoid deposition http://purl.obolibrary.org/obo/MPATH_178 extracellular matrix deposition Deposition of organic bone matrix. http://purl.obolibrary.org/obo/MPATH_641 epidermal inclusion cyst http://purl.obolibrary.org/obo/MPATH_62 cyst Intradermal or subcutaneous cyst, the wall of which is stratified epithelium containing keratohyalin granules, surrounding a core of debris. http://purl.obolibrary.org/obo/MPATH_642 cholesterol deposition http://purl.obolibrary.org/obo/MPATH_33 intracellular and extracellular accumulation Intra or extracellular deposition of cholesterol. http://purl.obolibrary.org/obo/MPATH_643 serous exudate http://purl.obolibrary.org/obo/MPATH_106 fluid accumulation Non-cellular fluid that filters from the circulatory system and accumulates in lesions or areas of inflammation. http://purl.obolibrary.org/obo/MPATH_644 crystalloid formation http://purl.obolibrary.org/obo/MPATH_33 intracellular and extracellular accumulation Accumulation of chitinase-like protein. http://purl.obolibrary.org/obo/MPATH_652 histiocytosis http://purl.obolibrary.org/obo/MPATH_602 hyperplastic tissue Benign proliferation of histiocytes. http://purl.obolibrary.org/obo/MPATH_656 hemolysis http://purl.obolibrary.org/obo/MPATH_25 tissue specific degenerative process Rupture or disruption of erythrocytes with release of contents. http://purl.obolibrary.org/obo/MPATH_67 displacement and deformity http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect Abnormal location, orientation, number, loss or non-specified deformity of a structure or tissue. http://purl.obolibrary.org/obo/MPATH_670 granulomatous epicarditis http://purl.obolibrary.org/obo/MPATH_645 epicarditis A mixed inflammatory cell infiltrate, primarily macrophages and some syncitial cells, around the heart attached to the epicardium. http://purl.obolibrary.org/obo/MPATH_7 coagulation necrosis http://purl.obolibrary.org/obo/MPATH_4 necrosis A type of necrosis in which the affected cells or tissue are reduced to homogeneous eosinophilic mass without nuclear staining, as a result of the protein coagulation, eg. Infarct. Tissue architecture persists. http://purl.obolibrary.org/obo/MPATH_708 pyelectasia http://purl.obolibrary.org/obo/MPATH_33 intracellular and extracellular accumulation Distension of the renal pelvis by accumulated fluid or urine. http://purl.obolibrary.org/obo/MPATH_71 fusion process defect http://purl.obolibrary.org/obo/MPATH_599 developmental process abnormalities Failure of two or more structures ( not voids or lumens) to join together. http://purl.obolibrary.org/obo/MPATH_72 growth acceleration http://purl.obolibrary.org/obo/MPATH_599 developmental process abnormalities Increase in the rate of growth of an organism, organ or tissue as a consequence of increased proliferation, reduced cell death, or a combination. Not due to an increase in cell size; see Hypertrophy MPATH: 159. http://purl.obolibrary.org/obo/MPATH_721 sacrococcygeal teratoma http://purl.obolibrary.org/obo/MPATH_322 teratoma Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Sacrococcygeal tumors are located at the base of the coccyx. http://purl.obolibrary.org/obo/MPATH_724 xanthoma http://purl.obolibrary.org/obo/MPATH_42 lipid deposition Dermal, subcutaneous, or tendinous lesions characterized by accumulations of lipid-laden macrophages often rich in cholesterol. http://purl.obolibrary.org/obo/MPATH_73 growth arrest http://purl.obolibrary.org/obo/MPATH_599 developmental process abnormalities The cessation of fetal or embryonic growth beyond a particular stage. http://purl.obolibrary.org/obo/MPATH_733 mucometra http://purl.obolibrary.org/obo/MPATH_547 mucous secretions A uterus distended with a fluid containing large quantities of mucin. http://purl.obolibrary.org/obo/MPATH_735 molar hypercementosis http://purl.obolibrary.org/obo/MPATH_33 intracellular and extracellular accumulation Thickening of the cementum layer of the molars. http://purl.obolibrary.org/obo/MPATH_739 sub-retinal hemorrhage http://purl.obolibrary.org/obo/MPATH_119 hemorrhage and non-specified extravasation Extravascular blood between retina and choroid http://purl.obolibrary.org/obo/MPATH_740 drusen http://purl.obolibrary.org/obo/MPATH_45 protein deposition Tiny yellow or white deposits of lamellar or amorphous extracellular material that build up between retina and retinal pigment epithelium. http://purl.obolibrary.org/obo/MPATH_741 splenomegaly http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect An increase in size of the spleen. http://purl.obolibrary.org/obo/MPATH_742 intervertebral disk prolapse http://purl.obolibrary.org/obo/MPATH_626 prolapse Rupture of the intervertebral disc, usually dorsally to compress the spinal cord, secondary to trauma. http://purl.obolibrary.org/obo/MPATH_743 hepatic centrolobular fatty metamorphosis http://purl.obolibrary.org/obo/MPATH_622 steatosis Accumulation of clear large vacuoles in hepatocytes (most likely lipid pending frozen sections and oil red O or other lipid stains) around central veins. http://purl.obolibrary.org/obo/MPATH_744 pigmentary incontinence http://purl.obolibrary.org/obo/MPATH_47 intracellular and extracellular depletion Release of melanin pigment in the dermis. http://purl.obolibrary.org/obo/MPATH_745 zenker's necrosis http://purl.obolibrary.org/obo/MPATH_4 necrosis Degenerative changes in skeletal muscle including hyalinization, swelling, fragmentation, vacuolation eventually resulting in death of muscle fibers. http://purl.obolibrary.org/obo/MPATH_746 cartilagenous erosion http://purl.obolibrary.org/obo/MPATH_25 tissue specific degenerative process Fragmentation and erosion of articular cartilage. http://purl.obolibrary.org/obo/MPATH_747 renal tubular amyloidosis http://purl.obolibrary.org/obo/MPATH_34 amyloid deposition Pink amorphous material (amyloid) deposited within the renal tubules. http://purl.obolibrary.org/obo/MPATH_748 recanalised thrombus http://purl.obolibrary.org/obo/MPATH_125 thrombosis An old organized thrombus that has been recanalized to permit blood flow. http://purl.obolibrary.org/obo/MPATH_749 focal pulmonary fibrosis http://purl.obolibrary.org/obo/MPATH_181 fibrosis Various degrees of pulmonary interstitial fibrosis. http://purl.obolibrary.org/obo/MPATH_75 hernia http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect Protrusion of a loop or wall of an organ through an abnormal opening. http://purl.obolibrary.org/obo/MPATH_750 pulmonary adenomatosis http://purl.obolibrary.org/obo/MPATH_270 adenoma Neoplastic proliferation of cuboidal cells lining alveoli most likely type II pneumocytes. http://purl.obolibrary.org/obo/MPATH_751 pigment dispersion http://purl.obolibrary.org/obo/MPATH_47 intracellular and extracellular depletion Free pigment in anterior chamber/elsewhere in eye. http://purl.obolibrary.org/obo/MPATH_752 barbered http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect loss of hair resulting from a behavioral abnormality in which the mouse, or more often other mice mice in the same box, remove hairs, initially vibrissae, from each other. http://purl.obolibrary.org/obo/MPATH_753 gastric forestomach papillomatous hyperplasia http://purl.obolibrary.org/obo/MPATH_138 epithelial hyperplasia The forestomach of the mouse is lined by stratified squamous epithelia. At the limiting ridge there is hyperplasia to various degrees in which this epithelium proliferates to form raised areas on thin fibrovascular stalks. http://purl.obolibrary.org/obo/MPATH_754 splenic hemosiderosis http://purl.obolibrary.org/obo/MPATH_726 hemosiderosis Spleen contains foci of macrophages containing yellow brown pigment that is positive for iron using Prussian blue. http://purl.obolibrary.org/obo/MPATH_755 pulmonary interstitial mineralisation http://purl.obolibrary.org/obo/MPATH_555 mineralisation Small foci of mineralization within the interstitium between alveoli. http://purl.obolibrary.org/obo/MPATH_756 polyarteritis nodosa http://purl.obolibrary.org/obo/MPATH_682 arteritis Chronic inflammation in and around small and medium sized arteries, often in more than one location. http://purl.obolibrary.org/obo/MPATH_757 interstitial mineralization http://purl.obolibrary.org/obo/MPATH_555 mineralisation Foci of mineralization within the interstitium of a tissue. http://purl.obolibrary.org/obo/MPATH_758 renal interstitial mineralisation http://purl.obolibrary.org/obo/MPATH_757 interstitial mineralization Small foci of mineralization within the interstitium between tubules. http://purl.obolibrary.org/obo/MPATH_759 pseudocyesis http://purl.obolibrary.org/obo/MPATH_474 ectasia Appearance of clinical and/or subclinical signs and symptoms associated with pregnancy when the animal is not pregnant http://purl.obolibrary.org/obo/MPATH_76 heterotopia http://purl.obolibrary.org/obo/MPATH_67 displacement and deformity Congenital appearance of a body part or tissue or cell type in a region where it is not normally found ( topographical anomaly). http://purl.obolibrary.org/obo/MPATH_760 ovarian bursal cyst http://purl.obolibrary.org/obo/MPATH_637 bursal cyst Marked dilatation of the ovarian bursa. http://purl.obolibrary.org/obo/MPATH_761 muscle regeneration http://purl.obolibrary.org/obo/MPATH_607 healing and repair structure Linear palisaiding of nuclei within thin pale muscle fibers suggestive of repair. http://purl.obolibrary.org/obo/MPATH_762 thyroid follicle pleomorphism http://purl.obolibrary.org/obo/MPATH_33 intracellular and extracellular accumulation Thyroid gland follicles are filled with colloid but vary greatly in size. http://purl.obolibrary.org/obo/MPATH_763 sialocele http://purl.obolibrary.org/obo/MPATH_62 cyst Salivary gland duct occlusion resulting in massive enlargement forming a large cyst-like structure. http://purl.obolibrary.org/obo/MPATH_764 fracture http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect A fracture is the (local) separation of a bone into two, or more, pieces under the action of stress. http://purl.obolibrary.org/obo/MPATH_765 fracture and healing http://purl.obolibrary.org/obo/MPATH_764 fracture Break in bone associated with exostoses. http://purl.obolibrary.org/obo/MPATH_766 intestinal amyloidosis http://purl.obolibrary.org/obo/MPATH_34 amyloid deposition The lamina propria is distended with amorphous hyalinized material interpreted to be amyloid protein. http://purl.obolibrary.org/obo/MPATH_767 Meckel's diverticulum http://purl.obolibrary.org/obo/MPATH_68 diverticulum A Meckel's diverticulum is a pouch on the wall of the lower part of the intestine that is present at birth. http://purl.obolibrary.org/obo/MPATH_768 septic necrosis http://purl.obolibrary.org/obo/MPATH_4 necrosis Necrosis associated with or caused by local bacterial infection. http://purl.obolibrary.org/obo/MPATH_769 uterine septic necrosis http://purl.obolibrary.org/obo/MPATH_768 septic necrosis Necrosis of the uterine wall with large bacterial colonies on its surface. http://purl.obolibrary.org/obo/MPATH_77 homoeotic change http://purl.obolibrary.org/obo/MPATH_599 developmental process abnormalities Stricto sensu: replacement of one body part or tissue by an homologous structure or tissue, but commonly used incorrectly to describe non-homologous transformations better described as heterotopias or ectopias. http://purl.obolibrary.org/obo/MPATH_771 abnormal organ length http://purl.obolibrary.org/obo/MPATH_770 abnormal organ size Abnormality of extent of the normal long axis http://purl.obolibrary.org/obo/MPATH_772 abnormal organ mass http://purl.obolibrary.org/obo/MPATH_770 abnormal organ size Abnormal mass of organ http://purl.obolibrary.org/obo/MPATH_773 abnormal intestine length http://purl.obolibrary.org/obo/MPATH_771 abnormal organ length Abnormal length of the intestine. http://purl.obolibrary.org/obo/MPATH_774 focal hepatic coagulative necrosis http://purl.obolibrary.org/obo/MPATH_7 coagulation necrosis Focal necrosis in the liver often but not always associated with thrombosis. http://purl.obolibrary.org/obo/MPATH_775 compression http://purl.obolibrary.org/obo/MPATH_15 general degenerative process Exertion of abnormal force on a structure or structures usually resulting in deformation and damage. http://purl.obolibrary.org/obo/MPATH_776 spermatocoele http://purl.obolibrary.org/obo/MPATH_62 cyst A spermatocoele is a cyst that contains spermatozoa. . http://purl.obolibrary.org/obo/MPATH_777 urelithiasis http://purl.obolibrary.org/obo/MPATH_614 concretion Formation of urinary concretions in any part of the kidney. http://purl.obolibrary.org/obo/MPATH_778 corpora amylacea http://purl.obolibrary.org/obo/MPATH_614 concretion https://doi.org/10.1038/srep41807 http://purl.obolibrary.org/obo/MPATH_779 uretolithiasis http://purl.obolibrary.org/obo/MPATH_777 urelithiasis Formation or urinary concretions in the ureter. http://purl.obolibrary.org/obo/MPATH_78 incomplete closure http://purl.obolibrary.org/obo/MPATH_599 developmental process abnormalities Incomplete closure of a void or lumen due to failure of growth or fusion of bounding walls. http://purl.obolibrary.org/obo/MPATH_780 pseudoxanthoma elasticum http://purl.obolibrary.org/obo/MPATH_36 calcium deposition Pseudoxanthoma elasticum is a progressive disorder characterized by accumulated deposits of calcium and other minerals in elastic fibers. http://purl.obolibrary.org/obo/MPATH_781 encephalomalacia http://purl.obolibrary.org/obo/MPATH_25 tissue specific degenerative process Softening of brain tissue, usually caused by vascular insufficiency or degenerative changes. http://purl.obolibrary.org/obo/MPATH_782 phthisis bulbi http://purl.obolibrary.org/obo/MPATH_25 tissue specific degenerative process Collapse of the eye globe associated with degenerative changes. http://purl.obolibrary.org/obo/MPATH_783 B6 dermatitis http://purl.obolibrary.org/obo/MPATH_196 dermatitis Follicular dystrophy, rupture, foreign body reaction, ulceration, scarring, pseudoepitheliomatous hyperplasia are part of a syndrome commonly called B6 dermatitis in black strains of mice. http://purl.obolibrary.org/obo/MPATH_784 follicular atresia http://purl.obolibrary.org/obo/MPATH_25 tissue specific degenerative process Degeneration and resorption of an ovarian follicle before it reaches maturity and ruptures. http://purl.obolibrary.org/obo/MPATH_785 bone marrow granulopoiesis http://purl.obolibrary.org/obo/MPATH_188 immunopathological process Marked production of granulocytes, primarily neutrophils, usually in response to a major acute inflammatory response. http://purl.obolibrary.org/obo/MPATH_786 inspissation http://purl.obolibrary.org/obo/MPATH_15 general degenerative process The drying, thickening and coagulation of extracellular secretions or fluids. http://purl.obolibrary.org/obo/MPATH_787 intervertebral disk prolapse ventral http://purl.obolibrary.org/obo/MPATH_742 intervertebral disk prolapse Ventral prolapse of the intervertebral disk. http://purl.obolibrary.org/obo/MPATH_788 testicular torsion http://purl.obolibrary.org/obo/MPATH_562 torsion The testicle twisted around the vascular tract to constrict flow resulting in liquifactive necrosis of the affected testicle. http://purl.obolibrary.org/obo/MPATH_789 trichogranuloma http://purl.obolibrary.org/obo/MPATH_847 granuloma Dermal granuloma surrounding hair fibers. http://purl.obolibrary.org/obo/MPATH_79 malposition http://purl.obolibrary.org/obo/MPATH_76 heterotopia Abnormal position or orientation of a structure insufficient to be called a heterotopia. http://purl.obolibrary.org/obo/MPATH_790 bilateral retinal degeneration http://purl.obolibrary.org/obo/MPATH_737 retinal degeneration Retinal degeneration of both eyes. http://purl.obolibrary.org/obo/MPATH_791 cartilagenous embolism http://purl.obolibrary.org/obo/MPATH_110 embolus Occlusion of a vessel by a piece of dissected cartilage. http://purl.obolibrary.org/obo/MPATH_792 lymph node reticuloendothelial cell hyperplasia http://purl.obolibrary.org/obo/MPATH_602 hyperplastic tissue Proliferation of the reticuloendothelial cells in the medulla of the lymph node. http://purl.obolibrary.org/obo/MPATH_793 reactive splenomegaly http://purl.obolibrary.org/obo/MPATH_188 immunopathological process An increase in the size of the spleen due to ongoing acute or chronic infection. http://purl.obolibrary.org/obo/MPATH_794 melena http://purl.obolibrary.org/obo/MPATH_119 hemorrhage and non-specified extravasation Digested blood in the lumen of the stomach or small intestine, indicative of hemorrhage. http://purl.obolibrary.org/obo/MPATH_795 psammoma body http://purl.obolibrary.org/obo/MPATH_36 calcium deposition Round , often laminar, non-proteinaceous eosinophilic bodies representing calcium deposition. http://purl.obolibrary.org/obo/MPATH_796 aspermia http://purl.obolibrary.org/obo/MPATH_797 spermatogenesis defect Lack of sperm. http://purl.obolibrary.org/obo/MPATH_797 spermatogenesis defect http://purl.obolibrary.org/obo/MPATH_604 defective growth and differentiation process Compromise or abnormality of the process of spermatogenesis http://purl.obolibrary.org/obo/MPATH_798 hypospermia http://purl.obolibrary.org/obo/MPATH_797 spermatogenesis defect Reduced numbers of sperm. http://purl.obolibrary.org/obo/MPATH_799 scoliosis http://purl.obolibrary.org/obo/MPATH_871 spinal structural defects scoliosis is an abnormal curvature of the spine. The spine curves away from the middle or sideways. http://purl.obolibrary.org/obo/MPATH_8 fat necrosis http://purl.obolibrary.org/obo/MPATH_4 necrosis Dead and dying adipose tissue, characterized by the formation of small gray or white foci of soapy (saponified) cellular debris. http://purl.obolibrary.org/obo/MPATH_80 obstruction and stenosis http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect Occlusion ( partial or complete) of a lumen or space, internally by a space occupying mass or, in the case of stenosis, by local reduction in the diameter of a vessel, duct or the intestine. http://purl.obolibrary.org/obo/MPATH_800 intervertebral disk prolapse dorsal http://purl.obolibrary.org/obo/MPATH_742 intervertebral disk prolapse Dorsal prolapse of the intervertebral disk. http://purl.obolibrary.org/obo/MPATH_801 intervertebral disks prolapsed dorsally and ventrally http://purl.obolibrary.org/obo/MPATH_742 intervertebral disk prolapse Presence of dorsal and ventrally prolapsed disks in the same vertebral column. http://purl.obolibrary.org/obo/MPATH_802 rectal prolapse http://purl.obolibrary.org/obo/MPATH_626 prolapse Eversion through the anus. http://purl.obolibrary.org/obo/MPATH_803 trabecular bone thickening http://purl.obolibrary.org/obo/MPATH_126 growth and differentiation defect Thickening of trabecular bone. http://purl.obolibrary.org/obo/MPATH_804 cavernous lymphangioma http://purl.obolibrary.org/obo/MPATH_420 lymphangioma Large numbers of thin-walled dilated lymphatic channels situated in the dermis, subcutis or skeletal muscle. http://purl.obolibrary.org/obo/MPATH_805 cystic hygroma http://purl.obolibrary.org/obo/MPATH_420 lymphangioma Variant of cavernous lymphangioma (MPATH:804) showing gross dilatation of lymphatic channels. http://purl.obolibrary.org/obo/MPATH_806 lymphangioma circumscriptum http://purl.obolibrary.org/obo/MPATH_420 lymphangioma Cutaneous grouped collection of thin-walled translucent vessels, which appear at birth or in early infancy and are commonest around the limb girdles. http://purl.obolibrary.org/obo/MPATH_807 hygroma http://purl.obolibrary.org/obo/MPATH_62 cyst Large cystic subcutaneous spaces usually found in the flexures, especially around the neck. http://purl.obolibrary.org/obo/MPATH_808 lymphedema http://purl.obolibrary.org/obo/MPATH_109 edema Accumulation of interstitial fluid caused by blockage or failure of the lymphatic system. http://purl.obolibrary.org/obo/MPATH_809 nuchal edema http://purl.obolibrary.org/obo/MPATH_109 edema Edema of the posterior aspect of the fetal neck caused by an accumulation of fluid, usually lymph. http://purl.obolibrary.org/obo/MPATH_810 follicular dystrophy http://purl.obolibrary.org/obo/MPATH_554 dystrophy Degenerative changes in hair follicles resulting in a deformed hair fiber, sometimes root sheath hyperplasia and follicular rupture. http://purl.obolibrary.org/obo/MPATH_811 epicardial mineralization http://purl.obolibrary.org/obo/MPATH_555 mineralisation Deposition of minerals in the epicardium. http://purl.obolibrary.org/obo/MPATH_812 blister http://purl.obolibrary.org/obo/MPATH_1 cell and tissue damage A collection of fluid underneath the top layer of skin (epidermis). http://purl.obolibrary.org/obo/MPATH_813 epidermolysis bullosa lesions http://purl.obolibrary.org/obo/MPATH_812 blister Lesions of a connective tissue disease causing blisters in the skin and mucosal membranes. http://purl.obolibrary.org/obo/MPATH_814 focal hepatic lipidosis http://purl.obolibrary.org/obo/MPATH_622 steatosis Locally circumscribed regions of fatty change. http://purl.obolibrary.org/obo/MPATH_815 macrovesicular lipidosis http://purl.obolibrary.org/obo/MPATH_622 steatosis subtype of steatosis with Hepatocytes containing a large well-defined single rounded vacuole within each cell, nucleus and cytoplasm displaced to the periphery, http://purl.obolibrary.org/obo/MPATH_816 microvesicular lipidosis http://purl.obolibrary.org/obo/MPATH_622 steatosis Variant form of hepatic steatosis. Hepatocytes partially or completely filled with numerous small lipid vacuoles. Affected hepatocytes may have a foamy appearance.Small vacuoles do not normally displace the nucleus to the periphery in contrast to macrovesicular lipidosis. http://purl.obolibrary.org/obo/MPATH_817 hydropic degeneration http://purl.obolibrary.org/obo/MPATH_15 general degenerative process Form of degenerative process in which there is Intracytoplasmic fluid accumulation secondary to disturbance of cell membrane integrity. http://purl.obolibrary.org/obo/MPATH_82 persistent embryonic structure http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect Persistence of an embryonic structure or tissue into the post-natal period in its normal location; (Chronological/temporal anomaly). http://purl.obolibrary.org/obo/MPATH_820 goitre http://purl.obolibrary.org/obo/MPATH_602 hyperplastic tissue Increase in size of the thyroid gland caused initially by uniform follicular epithelial hyperplasia generally in response to iodine deficiency. http://purl.obolibrary.org/obo/MPATH_821 hypoplastic tissue http://purl.obolibrary.org/obo/MPATH_126 growth and differentiation defect Tissue showing smaller mass as a consequence of deficient proliferation or premature differentiation. http://purl.obolibrary.org/obo/MPATH_822 hypoplastic gut associated lymphoid tissue http://purl.obolibrary.org/obo/MPATH_821 hypoplastic tissue Reduced mass of GALT resulting form fewer cells. http://purl.obolibrary.org/obo/MPATH_823 myxofibroma http://purl.obolibrary.org/obo/MPATH_407 fibroma A benign neoplasm characterized by mucous and fibroblastic tissues. http://purl.obolibrary.org/obo/MPATH_824 myofibroma http://purl.obolibrary.org/obo/MPATH_407 fibroma A benign localized neoplasm arising from the subcutaneous tissues and skeletal muscle. It is characterized by the presence of myofibroblastic hyperchromatic spindle cells, hylanized stroma formation, calcification, necrosis, and a multinodular growth pattern. http://purl.obolibrary.org/obo/MPATH_825 vacuolation http://purl.obolibrary.org/obo/MPATH_15 general degenerative process Generation of intracytoplasmic vacuoles otherwise unspecified. http://purl.obolibrary.org/obo/MPATH_826 granulomatous dermatitis http://purl.obolibrary.org/obo/MPATH_215 granulomatous inflammation granulomatous inflammation of the skin http://purl.obolibrary.org/obo/MPATH_827 chronic dermatitis http://purl.obolibrary.org/obo/MPATH_214 chronic inflammation chronic inflammation of the skin http://purl.obolibrary.org/obo/MPATH_828 focal dermatitis http://purl.obolibrary.org/obo/MPATH_196 dermatitis locally demarcated region of inflammation in the skin http://purl.obolibrary.org/obo/MPATH_829 true hermaphrodite http://purl.obolibrary.org/obo/MPATH_86 organ specific developmental defect possession of both ovary and testis due to primary sex determination defect http://purl.obolibrary.org/obo/MPATH_83 septation defect http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect Any defect in the formation of septae not describable as perforation. http://purl.obolibrary.org/obo/MPATH_830 regeneration http://purl.obolibrary.org/obo/MPATH_604 defective growth and differentiation process repair, reproduction, or replacement of lost or injured cells, tissues, or organs. http://purl.obolibrary.org/obo/MPATH_831 multifocal muscle regeneration http://purl.obolibrary.org/obo/MPATH_830 regeneration multilocular sites of muscle regeneration with centrally located nuclei. http://purl.obolibrary.org/obo/MPATH_832 paraphimosis http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect persistent retraction of the prepuce behind the glans penis http://purl.obolibrary.org/obo/MPATH_833 subacute inflammation http://purl.obolibrary.org/obo/MPATH_212 inflammation transition between acute and chronic inflammation. http://purl.obolibrary.org/obo/MPATH_834 ovarian tubulostromal tumor http://purl.obolibrary.org/obo/MPATH_556 potentially cancerous lesions non-malignant neoplasia of the ovary. http://purl.obolibrary.org/obo/MPATH_835 acute septic inflammation http://purl.obolibrary.org/obo/MPATH_213 acute inflammation acute inflammation due to infection. http://purl.obolibrary.org/obo/MPATH_836 dermal fibrosis http://purl.obolibrary.org/obo/MPATH_181 fibrosis fibrosis in the skin http://purl.obolibrary.org/obo/MPATH_837 hepatic mid-zonal fatty metamorphosis http://purl.obolibrary.org/obo/MPATH_622 steatosis Fatty change in the mid-zonal region of the liver. http://purl.obolibrary.org/obo/MPATH_838 anaplastic carcinoma http://purl.obolibrary.org/obo/MPATH_549 carcinoma carcinoma with an absence of epithelial structural differentiation. http://purl.obolibrary.org/obo/MPATH_839 anaplastic hepatocellular carcinoma http://purl.obolibrary.org/obo/MPATH_357 hepatocellular carcinoma anaplastic carcinoma of the liver. http://purl.obolibrary.org/obo/MPATH_84 supernumerary structure http://purl.obolibrary.org/obo/MPATH_67 displacement and deformity Additional structure whether normally located or not. http://purl.obolibrary.org/obo/MPATH_840 granulomatous arthritis http://purl.obolibrary.org/obo/MPATH_195 arthritis arthitis involving extensive macrophage infiltration into the joint. http://purl.obolibrary.org/obo/MPATH_841 anopthalmia http://purl.obolibrary.org/obo/MPATH_86 organ specific developmental defect Absence of eye. http://purl.obolibrary.org/obo/MPATH_842 coccygeal hemivertebrae http://purl.obolibrary.org/obo/MPATH_67 displacement and deformity abnormally shaped vertebral body often triangular as opposed to rectangular. http://purl.obolibrary.org/obo/MPATH_843 stasis http://purl.obolibrary.org/obo/MPATH_80 obstruction and stenosis Cessation of movement of a body fluid or liquid. http://purl.obolibrary.org/obo/MPATH_844 biliary stasis http://purl.obolibrary.org/obo/MPATH_843 stasis Cessation of the flow of bile due to bile duct blockage or overproduction. http://purl.obolibrary.org/obo/MPATH_845 partial abortion http://purl.obolibrary.org/obo/MPATH_100 placental abnormality Evidence of residual placenta in utero without embryo. http://purl.obolibrary.org/obo/MPATH_846 foreign body acute pododermatitis http://purl.obolibrary.org/obo/MPATH_659 foreign body dermatitis acute inflammation of the footpad caused by foreign body. http://purl.obolibrary.org/obo/MPATH_847 granuloma http://purl.obolibrary.org/obo/MPATH_215 granulomatous inflammation Collection of epithelioid macrophages into a nodule http://purl.obolibrary.org/obo/MPATH_848 effacing granuloma http://purl.obolibrary.org/obo/MPATH_847 granuloma Replacement of normal tissue by granuloma. http://purl.obolibrary.org/obo/MPATH_849 anaplastic mammary adenocarcinoma http://purl.obolibrary.org/obo/MPATH_268 adenocarcinoma poorly differentiated adenocarcinoma of the mammary gland http://purl.obolibrary.org/obo/MPATH_85 transdifferentiation http://purl.obolibrary.org/obo/MPATH_599 developmental process abnormalities Alteration in the differentiation of a cell or tissue already showing a different, recognisable, differentiated state. http://purl.obolibrary.org/obo/MPATH_852 plasmacytosis http://purl.obolibrary.org/obo/MPATH_194 immune mediated disease A condition in which there is an unusually large proportion of plasma cells in tissues, exudates, or blood. http://purl.obolibrary.org/obo/MPATH_853 systemic plasmacytosis http://purl.obolibrary.org/obo/MPATH_852 plasmacytosis Abnormality of circulating plasma cells http://purl.obolibrary.org/obo/MPATH_854 cutaneous plasmacytosis http://purl.obolibrary.org/obo/MPATH_852 plasmacytosis Plasmacytosis in the skin. http://purl.obolibrary.org/obo/MPATH_855 Splendore-Hoeppli phenomenon http://purl.obolibrary.org/obo/MPATH_194 immune mediated disease In vivo formation of intensely eosinophilic material (radiate, star-like, asteroid or club-shaped configurations) around microorganisms (fungi, bacteria and parasites) or biologically inert substances. http://purl.obolibrary.org/obo/MPATH_856 bullous emphysema http://purl.obolibrary.org/obo/MPATH_31 emphysema Rupture of alveolar walls result in large rounded open air spaces in the lung http://purl.obolibrary.org/obo/MPATH_857 multifocal bullous emphysema http://purl.obolibrary.org/obo/MPATH_856 bullous emphysema mutilocular bullous emphysema http://purl.obolibrary.org/obo/MPATH_858 capillary hemangioma http://purl.obolibrary.org/obo/MPATH_240 hemangioma Benign proliferation of capillaries made up of closely packed aggregations of capillaries, usually of normal caliber, separated by scant connective stroma. http://purl.obolibrary.org/obo/MPATH_859 botryomycosis http://purl.obolibrary.org/obo/MPATH_627 pyogranulomatous inflammation Chronic granulomatous bacterial infection that affects the skin, and sometimes the viscera. Usually caused by S. aureus. http://purl.obolibrary.org/obo/MPATH_860 cholecystitis http://purl.obolibrary.org/obo/MPATH_212 inflammation inflammation of the gall bladder http://purl.obolibrary.org/obo/MPATH_861 edematous cholecystitis http://purl.obolibrary.org/obo/MPATH_860 cholecystitis cholecystitis associated with edema http://purl.obolibrary.org/obo/MPATH_862 flatus http://purl.obolibrary.org/obo/MPATH_33 intracellular and extracellular accumulation Accumulation or trapping of air http://purl.obolibrary.org/obo/MPATH_863 focal ulcerative dermatitis http://purl.obolibrary.org/obo/MPATH_196 dermatitis circumscribed ulceration of the skin penetrating the basement membrane as part of inflammation process. http://purl.obolibrary.org/obo/MPATH_864 otitis externa http://purl.obolibrary.org/obo/MPATH_212 inflammation Inflammation of the outer ear. http://purl.obolibrary.org/obo/MPATH_865 foreign body acute papillomatous glossitis http://purl.obolibrary.org/obo/MPATH_662 foreign body glossitis Papillomatous inflammation of the tongue caused by a foreign body. http://purl.obolibrary.org/obo/MPATH_866 gastric adenomatous hyperplasia http://purl.obolibrary.org/obo/MPATH_138 epithelial hyperplasia Thickening of the glandular epithelium http://purl.obolibrary.org/obo/MPATH_867 hepatic central vein perivascular fibrosis http://purl.obolibrary.org/obo/MPATH_181 fibrosis Major hepatic vein surrounded by fibrous connective tissue. http://purl.obolibrary.org/obo/MPATH_868 uterine ectasia http://purl.obolibrary.org/obo/MPATH_474 ectasia Dilation of the uterus http://purl.obolibrary.org/obo/MPATH_869 intussception http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect Condition in which a part of the intestine has invaginated into another section of intestine, http://purl.obolibrary.org/obo/MPATH_87 germ cell defect http://purl.obolibrary.org/obo/MPATH_86 organ specific developmental defect Abnormal morphology, differentiation or location of primordial germ cells or their descendents. Not neoplastic. http://purl.obolibrary.org/obo/MPATH_870 junctional epidermolysis bullosa http://purl.obolibrary.org/obo/MPATH_813 epidermolysis bullosa lesions severe type of the disorder generally apparent at birth.Junctional epidermolysis bullosa involves defects in hemidesmosomes. t http://purl.obolibrary.org/obo/MPATH_871 spinal structural defects http://purl.obolibrary.org/obo/MPATH_86 organ specific developmental defect Structural defects of the bony and muscular components of the vertebrae. http://purl.obolibrary.org/obo/MPATH_872 kyphosis http://purl.obolibrary.org/obo/MPATH_871 spinal structural defects Abnormality of the kyphotic curvature of the spine. http://purl.obolibrary.org/obo/MPATH_873 micropthalmia http://purl.obolibrary.org/obo/MPATH_770 abnormal organ size Reduced size of the eye globe. http://purl.obolibrary.org/obo/MPATH_874 plasmacytosis http://purl.obolibrary.org/obo/MPATH_602 hyperplastic tissue Plasmacytosis is a hyperplastic condition in which there is an unusually large proportion of mature plasma cells in tissues, exudates, or blood. http://purl.obolibrary.org/obo/MPATH_875 cutaneous plasmacytosis http://purl.obolibrary.org/obo/MPATH_874 plasmacytosis cutaneous manifestation of plasmacytosis http://purl.obolibrary.org/obo/MPATH_876 systemic plasmacytosis http://purl.obolibrary.org/obo/MPATH_874 plasmacytosis systemic manifestation of plasmacytosis. Disseminated in the circulation. http://purl.obolibrary.org/obo/MPATH_877 pneumonia http://purl.obolibrary.org/obo/MPATH_212 inflammation An inflammatory condition of the lung, especially affecting the alveoli, associated with fever, chest symptoms, and congestion. http://purl.obolibrary.org/obo/MPATH_878 foreign body aspiration pneumonia http://purl.obolibrary.org/obo/MPATH_877 pneumonia Pneumonia caused by aspiration of a foreign body. http://purl.obolibrary.org/obo/MPATH_879 gingivitis http://purl.obolibrary.org/obo/MPATH_212 inflammation Inflammation of the tooth gum http://purl.obolibrary.org/obo/MPATH_880 foreign body gingivitis http://purl.obolibrary.org/obo/MPATH_879 gingivitis inflammation of the tooth gum caused by a foreign body. http://purl.obolibrary.org/obo/MPATH_881 reactive fibrosis http://purl.obolibrary.org/obo/MPATH_181 fibrosis Fibrotic reaction to presence of a foreign body. http://purl.obolibrary.org/obo/MPATH_882 hepatic peri-ductal inflammation http://purl.obolibrary.org/obo/MPATH_212 inflammation Inflammatory cell infiltrate around bile ducts within the liver. http://purl.obolibrary.org/obo/MPATH_883 pneumonitis http://purl.obolibrary.org/obo/MPATH_212 inflammation An interstitial, granulomatous, fibrosing inflammation of the lung, especially of the bronchioles and alveoli. http://purl.obolibrary.org/obo/MPATH_884 histiocytic pneumonitis http://purl.obolibrary.org/obo/MPATH_883 pneumonitis Pneumonitis involving subpleural histiocytosis. http://purl.obolibrary.org/obo/MPATH_885 metastatic tumor http://purl.obolibrary.org/obo/MPATH_218 neoplasm metastatic tumour of unspecified origin http://purl.obolibrary.org/obo/MPATH_886 pulmonary metastasis http://purl.obolibrary.org/obo/MPATH_885 metastatic tumor Metastatic tumour of unspecified origin in the lung. http://purl.obolibrary.org/obo/MPATH_887 lymphatic metastasis http://purl.obolibrary.org/obo/MPATH_885 metastatic tumor Metastatic tumor in the lymphatic vessels or lymph nodes of unspecified origin. http://purl.obolibrary.org/obo/MPATH_888 onychogryphosis http://purl.obolibrary.org/obo/MPATH_631 hypertrophic tissue Hypertrophy of the nail bed resulting in abnormally long, curved and thickened nails. http://purl.obolibrary.org/obo/MPATH_9 fibrinoid necrosis http://purl.obolibrary.org/obo/MPATH_4 necrosis Necrosis in which the necrotic tissue shows deeply eosinophilic staining similar to that of fibrin. http://purl.obolibrary.org/obo/MPATH_91 arteriovenous anastomosis http://purl.obolibrary.org/obo/MPATH_89 cardiovascular developmental defect Formation of vessels between arterioles and venules bypassing capillary circulation. http://purl.obolibrary.org/obo/MPATH_92 cardiac defect http://purl.obolibrary.org/obo/MPATH_89 cardiovascular developmental defect Structural, organisational or growth related defects in cardiac development. http://purl.obolibrary.org/obo/MPATH_93 cardiac septation defect http://purl.obolibrary.org/obo/MPATH_92 cardiac defect Abnormality in the wall between the atria or ventricles, or defects in the truncoconal septum, of the heart; usually incomplete closure. http://purl.obolibrary.org/obo/MPATH_94 valve defect http://purl.obolibrary.org/obo/MPATH_92 cardiac defect Malformation of the membranous folds of the heart that prevent reflux of fluid. http://purl.obolibrary.org/obo/MPATH_95 hypertrophic ventricle http://purl.obolibrary.org/obo/MPATH_92 cardiac defect Thickening of the wall of one or both of the heart ventricles. http://purl.obolibrary.org/obo/MPATH_96 hypoplastic ventricle http://purl.obolibrary.org/obo/MPATH_92 cardiac defect Reduction in cell number of one or both of the two lower chambers of the heart. http://purl.obolibrary.org/obo/MPATH_99 varices http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect An enlarged and often tortuous vein. http://purl.obolibrary.org/obo/MPATH_373 CNS progenitor tumor http://purl.obolibrary.org/obo/MPATH_565 tumors of neurepithelial tissue Neoplasms derived from neuroepithelial precursors. http://purl.obolibrary.org/obo/MPATH_119 hemorrhage and non-specified extravasation http://purl.obolibrary.org/obo/MPATH_105 circulatory disorder Abnormal release of whole blood or the cellular component from the circulation. http://purl.obolibrary.org/obo/MPATH_120 ecchymosis http://purl.obolibrary.org/obo/MPATH_119 hemorrhage and non-specified extravasation A red/purple patch caused by extravasation of blood into the skin. Larger than petechiae. http://purl.obolibrary.org/obo/MPATH_156 parakeratosis http://purl.obolibrary.org/obo/MPATH_154 hyperkeratosis Thickening of the surface cell layer of a stratified squamous epithelium with retention of nuclei in the cells of the stratum corneum. http://purl.obolibrary.org/obo/MPATH_181 fibrosis http://purl.obolibrary.org/obo/MPATH_176 connective tissue replacement Reactive formation of fibrous tissue. http://purl.obolibrary.org/obo/MPATH_184 sclerosis http://purl.obolibrary.org/obo/MPATH_176 connective tissue replacement Any pathological thickening or hardening of a tissue. http://purl.obolibrary.org/obo/MPATH_195 arthritis http://purl.obolibrary.org/obo/MPATH_212 inflammation Inflammation of a joint. http://purl.obolibrary.org/obo/MPATH_197 glomerulonephritis http://purl.obolibrary.org/obo/MPATH_212 inflammation Renal disease characterised by diffuse inflammatory changes in glomeruli not in response to an infectious agent or treatment. http://purl.obolibrary.org/obo/MPATH_198 immune mediated hemolytic anaemia http://purl.obolibrary.org/obo/MPATH_212 inflammation An anemic/erythrocytopenic condition resulting from an increased rate of immune mediated erythrocyte destruction. http://purl.obolibrary.org/obo/MPATH_201 vasculitis http://purl.obolibrary.org/obo/MPATH_212 inflammation Inflammation of a blood vessel. http://purl.obolibrary.org/obo/MPATH_28 atherosclerosis http://purl.obolibrary.org/obo/MPATH_25 tissue specific degenerative process Characterised by irregular lipid deposits in the wall of arteries, causing narrowing of their lumens and proceeding eventually to fibrosis and calcification. http://purl.obolibrary.org/obo/MPATH_31 emphysema http://purl.obolibrary.org/obo/MPATH_25 tissue specific degenerative process Abnormal accumulation of air in the interstitial connective tissue of a structure. Sensu Lung: Pulmonary emphysema; characterised by abnormal increase in the size of air (alveolar) spaces distal to the terminal bronchiole with degenerative changes in their walls and reduction in their number. http://purl.obolibrary.org/obo/MPATH_36 calcium deposition http://purl.obolibrary.org/obo/MPATH_555 mineralisation Intra or extracellular deposition of calcium usually as calcium phosphate. http://purl.obolibrary.org/obo/MPATH_476 telangiectasia http://purl.obolibrary.org/obo/MPATH_474 ectasia A lesion formed by a dilated capillary or terminal artery. http://purl.obolibrary.org/obo/MPATH_502 monocytic leukaemia http://purl.obolibrary.org/obo/MPATH_342 myeloid leukaemia Leukaemia in which neoplastic cells are poorly or moderately differentiated with a monocytic but no neutrophilic component. At least 20% of the cells must be blasts. http://purl.obolibrary.org/obo/MPATH_579 ulcer http://purl.obolibrary.org/obo/MPATH_1 cell and tissue damage Loss of epithelium and the basement membrane (full thickness). Cf Erosion. http://purl.obolibrary.org/obo/MPATH_608 abscess http://purl.obolibrary.org/obo/MPATH_607 healing and repair structure A circumscribed collection of purulent exudate frequently associated with swelling and other signs of inflammation. http://purl.obolibrary.org/obo/MPATH_615 cardiomyopathy http://purl.obolibrary.org/obo/MPATH_25 tissue specific degenerative process A disease of the heart muscle or myocardium proper. http://purl.obolibrary.org/obo/MPATH_62 cyst http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect Formation of an epithelium bounded cavity not associated with neoplasia. http://purl.obolibrary.org/obo/MPATH_68 diverticulum http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect A blind ended outpouching through the wall of a tubular organ or bounded cavity. http://purl.obolibrary.org/obo/MPATH_70 fistula http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect An abnormal passage between two internal organs or leading from a cavity to the body surface. http://purl.obolibrary.org/obo/MPATH_74 hamartoma http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect A focal malformation resembling a neoplasm which results from faulty development of an organ; composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element. Growth and location are usually normal for that tissue cf. Heterotopia/Choristoma MPATH:76/MPATH:477. http://purl.obolibrary.org/obo/MPATH_90 aneurysm http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect Localised dilation of an artery or heart chamber usually due to an acquired or congenital weakness of the wall of the artery or chamber. http://purl.obolibrary.org/obo/MPATH_392 chondrosarcoma http://purl.obolibrary.org/obo/MPATH_388 osseous and chondromatous tumor Malignant neoplasm derived form pluripotential mesenchymal cells, chondrocytes or chondroblasts. No production of osteoid. (M-9220/3). http://purl.obolibrary.org/obo/MPATH_110 embolus http://purl.obolibrary.org/obo/MPATH_105 circulatory disorder A plug formed from a variety of materials occluding a vessel or tube. http://purl.obolibrary.org/obo/MPATH_0 pathological entity http://purl.obolibrary.org/obo/MPATH_1000 pathological phenotype observation Pathological structure or process http://purl.obolibrary.org/obo/MPATH_1 cell and tissue damage http://purl.obolibrary.org/obo/MPATH_603 pathological anatomical entity The sum of morphological and functional disturbances induced by cell and tissue damage, either from intrinsic gene dysfunction or as a result of external factors. http://purl.obolibrary.org/obo/MPATH_105 circulatory disorder http://purl.obolibrary.org/obo/MPATH_603 pathological anatomical entity Lesions leading to or consequent on failure of, or atypical movement of, blood throughout the body. http://purl.obolibrary.org/obo/MPATH_121 hematoma http://purl.obolibrary.org/obo/MPATH_119 hemorrhage and non-specified extravasation A localised deposition of clotted or partially clotted extravasated blood. http://purl.obolibrary.org/obo/MPATH_126 growth and differentiation defect http://purl.obolibrary.org/obo/MPATH_603 pathological anatomical entity Defects in growth (changes in proliferation or mass) and differentiation of cells tissues or organs. http://purl.obolibrary.org/obo/MPATH_127 atrophy http://purl.obolibrary.org/obo/MPATH_604 defective growth and differentiation process A reduction in size of organs or tissues as a result of cell death, loss of cellularity of whatever cause, reduced cellular proliferation or decreased cellular volume. http://purl.obolibrary.org/obo/MPATH_14 process of degenerative change http://purl.obolibrary.org/obo/MPATH_597 cell and tissue damage process A pathological process of loss or degradation of function, or structural integrity, of a tissue, organ or cell. http://purl.obolibrary.org/obo/MPATH_149 squamous hyperplasia http://purl.obolibrary.org/obo/MPATH_602 hyperplastic tissue Benign proliferation of epidermal cells with hyperkeratosis. Variable growth pattern, regular to papillary (exophytic squamous cell hyperplasia). http://purl.obolibrary.org/obo/MPATH_150 acanthosis http://purl.obolibrary.org/obo/MPATH_149 squamous hyperplasia Hyperplasia of the Malpighian layer (prickle cell) of the epidermis. http://purl.obolibrary.org/obo/MPATH_154 hyperkeratosis http://purl.obolibrary.org/obo/MPATH_149 squamous hyperplasia Thickening of the surface layers (stratum corneum) in the skin or other stratified squamous epithelium. Cf. ortho- and para-keratosis. http://purl.obolibrary.org/obo/MPATH_160 metaplasia http://purl.obolibrary.org/obo/MPATH_604 defective growth and differentiation process Abnormal transformation of an fully differentiated adult cell or tissue of one kind into a differentiated tissue of another kind. An adult instance of developmental transdifferentiation MPATH:85 Traditionally defined as a form of abnormal regeneration in which a type of cell different from that found normally in a given location is produced. http://purl.obolibrary.org/obo/MPATH_162 epithelial metaplasia http://purl.obolibrary.org/obo/MPATH_605 metaplastic tissue Metaplasia occurring within epithelia. http://purl.obolibrary.org/obo/MPATH_164 gastric metaplasia http://purl.obolibrary.org/obo/MPATH_162 epithelial metaplasia Appearance of heterotopic gastric epithelium. http://purl.obolibrary.org/obo/MPATH_175 healing and repair process http://purl.obolibrary.org/obo/MPATH_596 pathological process The process, normal or abnormal, of damage repair or wound closure. http://purl.obolibrary.org/obo/MPATH_176 connective tissue replacement http://purl.obolibrary.org/obo/MPATH_175 healing and repair process Replacement of connective tissue by fibro-fatty deposits and scar tissue. http://purl.obolibrary.org/obo/MPATH_188 immunopathological process http://purl.obolibrary.org/obo/MPATH_596 pathological process Inappropriate or aberrant activation or suppression of the immune or inflammatory response. http://purl.obolibrary.org/obo/MPATH_194 immune mediated disease http://purl.obolibrary.org/obo/MPATH_188 immunopathological process Tissue response to inappropriate immune/inflammatory process. http://purl.obolibrary.org/obo/MPATH_196 dermatitis http://purl.obolibrary.org/obo/MPATH_212 inflammation Inflammation of the skin. http://purl.obolibrary.org/obo/MPATH_2 cell death http://purl.obolibrary.org/obo/MPATH_597 cell and tissue damage process Complete and irreversible cessation of metabolic activity. http://purl.obolibrary.org/obo/MPATH_200 myositis http://purl.obolibrary.org/obo/MPATH_212 inflammation Inflammation of a muscle. http://purl.obolibrary.org/obo/MPATH_212 inflammation http://purl.obolibrary.org/obo/MPATH_194 immune mediated disease A tissue reaction to an internal or external injury. http://purl.obolibrary.org/obo/MPATH_213 acute inflammation http://purl.obolibrary.org/obo/MPATH_212 inflammation Inflammation with a recent onset, characterised histologically by primarily granulocyte infiltration, edema and hyperemia. http://purl.obolibrary.org/obo/MPATH_214 chronic inflammation http://purl.obolibrary.org/obo/MPATH_212 inflammation Chronic inflammatory condition characterised by infiltration of primarily lymphocytes. http://purl.obolibrary.org/obo/MPATH_218 neoplasm http://purl.obolibrary.org/obo/MPATH_603 pathological anatomical entity A tumor resulting from abnormal and uncontrolled autonomous new cell growth (proliferation)that may be benign or malignant. http://purl.obolibrary.org/obo/MPATH_219 adnexal and skin appendage tumor http://purl.obolibrary.org/obo/MPATH_218 neoplasm Tumors of the skin, its constituent structures and glands including the mammary gland, apocrine and eccrine glands, hair follicles and associated structures. http://purl.obolibrary.org/obo/MPATH_232 trichoepithelioma http://purl.obolibrary.org/obo/MPATH_575 basaloid follicular neoplasms Multiple small benign nodules derived from basal cells of hair follicles enclosing small cornified cell containing cysts. (M-8100/0). http://purl.obolibrary.org/obo/MPATH_233 basal cell tumor http://purl.obolibrary.org/obo/MPATH_270 adenoma Well circumscribed tumor of the basal cells of the epidermis. Rare mitotic figures, benign. (M8147/0). http://purl.obolibrary.org/obo/MPATH_234 basal cell carcinoma http://purl.obolibrary.org/obo/MPATH_575 basaloid follicular neoplasms Malignant neoplasm of the basal cells of the epidermis with local invasion. (M-8090/3). http://purl.obolibrary.org/obo/MPATH_235 blood vessel tumor http://purl.obolibrary.org/obo/MPATH_218 neoplasm Tumor of venous or arterial vessels or capillaries. http://purl.obolibrary.org/obo/MPATH_236 angiofibroma http://purl.obolibrary.org/obo/MPATH_235 blood vessel tumor .A benign neoplasm of fibrous tissue in which there are multiple large and small dilated vascular channels ( M9160/0). http://purl.obolibrary.org/obo/MPATH_238 hemangioblastoma http://purl.obolibrary.org/obo/MPATH_235 blood vessel tumor A benign neoplasm frequently arising in the cerebellum composed of capillary vessel forming endothelial cells and stromal cells. (M-9161/1). http://purl.obolibrary.org/obo/MPATH_240 hemangioma http://purl.obolibrary.org/obo/MPATH_235 blood vessel tumor Neoplasm derived from endothelial cells. May be of capillary or cavernous type with large vascular channels. (M-9130/0 + M-9120/0 respectively). http://purl.obolibrary.org/obo/MPATH_242 hemangiosarcoma http://purl.obolibrary.org/obo/MPATH_551 sarcoma Malignant neoplasm derived from pluripotential mesenchymal stem cells or endothelial cells of blood vessels. (M-9120/3). http://purl.obolibrary.org/obo/MPATH_243 central nervous system tumor http://purl.obolibrary.org/obo/MPATH_218 neoplasm Neoplasm of the neurones, glia or meninges of the CNS. http://purl.obolibrary.org/obo/MPATH_244 astrocytoma http://purl.obolibrary.org/obo/MPATH_249 glioma Glioma derived from astrocytes, both benign and malignant forms (M-9400/3). http://purl.obolibrary.org/obo/MPATH_246 choroid plexus papilloma http://purl.obolibrary.org/obo/MPATH_565 tumors of neurepithelial tissue Benign neoplasm derived from the epithelial cells of the choroid plexus. (M-9390/0). http://purl.obolibrary.org/obo/MPATH_247 ependymoma http://purl.obolibrary.org/obo/MPATH_249 glioma Neoplasm derived from the ependymal cells lining the ventricles and aqueduct of the brain and the central canal of the spinal cord. Malignant or benign. (M-9391/3). http://purl.obolibrary.org/obo/MPATH_25 tissue specific degenerative process http://purl.obolibrary.org/obo/MPATH_14 process of degenerative change Degenerative process characteristic of a particular tissue. http://purl.obolibrary.org/obo/MPATH_250 medulloblastoma http://purl.obolibrary.org/obo/MPATH_373 CNS progenitor tumor Neoplasm derived from the primitive neurectodermal cells of the cerebellum. (M-9470/3). May be considered by some authorities a synonym of PNET in the CNS. http://purl.obolibrary.org/obo/MPATH_251 meningioma http://purl.obolibrary.org/obo/MPATH_566 tumors of the meninges meningioma http://purl.obolibrary.org/obo/MPATH_252 oligodendroglioma http://purl.obolibrary.org/obo/MPATH_249 glioma Benign or malignant neoplasm derived form oligodendrocytes (M-9450/3). http://purl.obolibrary.org/obo/MPATH_254 complex tumor http://purl.obolibrary.org/obo/MPATH_218 neoplasm Tumors showing multiple histological componants/differentiation. http://purl.obolibrary.org/obo/MPATH_261 nephroblastoma http://purl.obolibrary.org/obo/MPATH_254 complex tumor Embryonal tumor thought to be derived from metanephric blastema. Mono, bi or triphasic, sometimes with heterotypic differentiation. (M-8960/3). http://purl.obolibrary.org/obo/MPATH_262 pulmonary blastoma http://purl.obolibrary.org/obo/MPATH_254 complex tumor A biphasic tumor containing a primitive epithelial component, that may resemble well-differentiated fetal adenocarcinoma and a primitive mesenchymal stroma, which occasionally has foci of osteosarcoma, chondrosarcoma or rhadomyosarcoma. (M-8972/3). http://purl.obolibrary.org/obo/MPATH_264 fibroepithelial tumor http://purl.obolibrary.org/obo/MPATH_218 neoplasm Tumors with epithelial invaginations/linings and a fibrillary and fibrocytic stroma. (M-9000 - M-9030). http://purl.obolibrary.org/obo/MPATH_266 fibroadenoma http://purl.obolibrary.org/obo/MPATH_264 fibroepithelial tumor A benign neoplasm derived from glandular epithelium, in which there is a abundant stroma of proliferating fibroblasts and connective tissue. (M-9010/0). http://purl.obolibrary.org/obo/MPATH_267 glandular tumor http://purl.obolibrary.org/obo/MPATH_218 neoplasm Neoplasms derived from glandular epithelial cells. http://purl.obolibrary.org/obo/MPATH_268 adenocarcinoma http://purl.obolibrary.org/obo/MPATH_549 carcinoma Malignant neoplasm of epithelial cells in glandular or glandlike pattern. (M-8140/3). http://purl.obolibrary.org/obo/MPATH_270 adenoma http://purl.obolibrary.org/obo/MPATH_556 potentially cancerous lesions A benign epithelial neoplasm in which the tumor cells may form glands or glandlike structures. In different instances this may remain a benign tumor or progress to malignancy. http://purl.obolibrary.org/obo/MPATH_271 adenomatous polyposis coli http://purl.obolibrary.org/obo/MPATH_556 potentially cancerous lesions Spontaneous intestinal adenoma formation. Polyps increase in number, causing symptoms of chronic colitis and potentially transform into adenocarcinoma. (M-8220/0). http://purl.obolibrary.org/obo/MPATH_277 cystadenoma http://purl.obolibrary.org/obo/MPATH_270 adenoma A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. (M-8440/0). http://purl.obolibrary.org/obo/MPATH_278 follicular adenocarcinoma http://purl.obolibrary.org/obo/MPATH_268 adenocarcinoma Originates in the follicular cells of thyroid follicles. Papillary, solid and follicular forms. (M- 8330/3). http://purl.obolibrary.org/obo/MPATH_291 medullary carcinoma http://purl.obolibrary.org/obo/MPATH_549 carcinoma Derived from calcitonin-producing cells (thyroid). In humans a type of carcinoma composed of epithelial elements with considerable lymphoid stroma (breast). Not yet reported in mice. (M-8510/3). http://purl.obolibrary.org/obo/MPATH_295 papillary adenocarcinoma http://purl.obolibrary.org/obo/MPATH_268 adenocarcinoma A malignant neoplasm derived from a glandular epithelium, in which solid tumors show papillary structures projecting onto fibrovascular stroma. (M-8260/3). http://purl.obolibrary.org/obo/MPATH_298 papillary cystadenoma http://purl.obolibrary.org/obo/MPATH_270 adenoma A benign neoplasm derived from glandular epithelium, in which cysts contain folds or papillary projections into the lumen. (M-8450/0). http://purl.obolibrary.org/obo/MPATH_299 pinealoma http://purl.obolibrary.org/obo/MPATH_267 glandular tumor Originating from differentiated cells of the pineal parenchyma. Not to be confused with human pinealoma (syn: germinoma) non-gonadal germ cell tumors found in the pineal believed to be atypical teratomas. May be benign or malignant. If ectopic teratomas/teratocarcinomas use MP322 or MP321. (M-9360/1). http://purl.obolibrary.org/obo/MPATH_308 thyroid C-cell carcinoma http://purl.obolibrary.org/obo/MPATH_549 carcinoma Malignant neoplasm derived from the calcitonin producing C-cells of the thyroid gland. (M-8510/3, M-8345/3). http://purl.obolibrary.org/obo/MPATH_309 gonadal tumor http://purl.obolibrary.org/obo/MPATH_218 neoplasm Germ cell and non-germ cell tumors of the testis and ovary. http://purl.obolibrary.org/obo/MPATH_310 germ cell tumor http://purl.obolibrary.org/obo/MPATH_309 gonadal tumor Neoplasms derived from germ cells. May be gonadal or extragonadal and are derived from primordial germ cells. http://purl.obolibrary.org/obo/MPATH_312 dysgerminoma http://purl.obolibrary.org/obo/MPATH_310 germ cell tumor Undifferentiated germ cell tumor of the ovary composed of solid sheets of large polygonal cells with rim of clear cytoplasm (M-9060/3). http://purl.obolibrary.org/obo/MPATH_315 gonadoblastoma http://purl.obolibrary.org/obo/MPATH_310 germ cell tumor Gonadal neoplasms that consist of aggregates of germ cells and sex cord elements (M-9073/1). http://purl.obolibrary.org/obo/MPATH_316 mixed germ cell tumor http://purl.obolibrary.org/obo/MPATH_310 germ cell tumor Malignant neoplasm of the testis/ovary including various elements of germ cell tumors (M-9085/3). http://purl.obolibrary.org/obo/MPATH_317 seminoma http://purl.obolibrary.org/obo/MPATH_310 germ cell tumor Tumor derived from spermatogenic cells resembling spermatogenia or spermatocytes. NOS ( M9061/3). http://purl.obolibrary.org/obo/MPATH_321 teratocarcinoma http://purl.obolibrary.org/obo/MPATH_549 carcinoma Mixed germ cell neoplasm contaning elements of embryonal carcinoma and teratoma (M-9081/3). http://purl.obolibrary.org/obo/MPATH_322 teratoma http://purl.obolibrary.org/obo/MPATH_310 germ cell tumor Generally benign germ cell derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor. Malignant tumors are highly metatstatic. (M-9080/1). http://purl.obolibrary.org/obo/MPATH_323 gonadal somatic cell tumor http://purl.obolibrary.org/obo/MPATH_309 gonadal tumor Neoplasms derived from the non-germ cell derived tissues of the testis and ovary. http://purl.obolibrary.org/obo/MPATH_328 leydig cell tumor http://purl.obolibrary.org/obo/MPATH_323 gonadal somatic cell tumor Tumor derived from Leydig cells (M-8650/1). http://purl.obolibrary.org/obo/MPATH_33 intracellular and extracellular accumulation http://purl.obolibrary.org/obo/MPATH_1 cell and tissue damage Accumulation of substances within, on the surface of or between cells. http://purl.obolibrary.org/obo/MPATH_331 sertoli cell tumor http://purl.obolibrary.org/obo/MPATH_323 gonadal somatic cell tumor Tumor derived from sex cord/stromal cells; Sertoli cells and can occur in both testis and ovary. (M-8640/1). http://purl.obolibrary.org/obo/MPATH_335 hematopoietic/lymphoid malignancies/disorder http://purl.obolibrary.org/obo/MPATH_218 neoplasm Proliferative disorders and malignancies of the lymphoid and non lymphoid haematopoietic lineages. http://purl.obolibrary.org/obo/MPATH_342 myeloid leukaemia http://purl.obolibrary.org/obo/MPATH_496 Non-Lymphoid leukaemias Leukaemias of the myeloid lineage. http://purl.obolibrary.org/obo/MPATH_351 thymoma http://purl.obolibrary.org/obo/MPATH_556 potentially cancerous lesions A neoplasm in the anterior mediastinum, originating from thymic tissue, usually benign, and frequently encapsulated; occasionally invasive, but metastases are rare; histologically, consists of any type of thymic epithelial cell as well as lymphocytes that are usually abundant. (M-8580/1). http://purl.obolibrary.org/obo/MPATH_352 hepatic tumor http://purl.obolibrary.org/obo/MPATH_218 neoplasm Tumors of the liver and biliary apparatus. http://purl.obolibrary.org/obo/MPATH_353 hepatocellular adenoma http://purl.obolibrary.org/obo/MPATH_352 hepatic tumor Benign neoplasm derived from hepatocytes. (M- 8170/0). http://purl.obolibrary.org/obo/MPATH_354 cholangiocarcinoma http://purl.obolibrary.org/obo/MPATH_549 carcinoma Malignant tumor derived from the bile duct epithelium. (M8160/3). http://purl.obolibrary.org/obo/MPATH_356 hepatoblastoma http://purl.obolibrary.org/obo/MPATH_352 hepatic tumor Malignant neoplasm of the liver of unknown origin . Liver blastemal cells, neoplastic hepatocytes, oval cells and biliary epithelial cells have been proposed. (M- 8970/3). http://purl.obolibrary.org/obo/MPATH_357 hepatocellular carcinoma http://purl.obolibrary.org/obo/MPATH_549 carcinoma Malignant tumor derived from hepatocytes. (M- 8170/3). http://purl.obolibrary.org/obo/MPATH_358 melanocytic tumor http://purl.obolibrary.org/obo/MPATH_219 adnexal and skin appendage tumor Tumors derived from melanocytes. http://purl.obolibrary.org/obo/MPATH_359 melanoma http://purl.obolibrary.org/obo/MPATH_358 melanocytic tumor Tumor of neurectodermal origin, usually melanocytes, showing dense deposition of melanin granules, although amelanotic melanomas have been reported. (M-8720/3). http://purl.obolibrary.org/obo/MPATH_360 melanoma in situ http://purl.obolibrary.org/obo/MPATH_556 potentially cancerous lesions A potentially malignant lesion, melanoma in situ is the first phase of growth of melanoma, in which it is still confined to the epithelial domain (epidermis and adnexa) and has not passed through the basement membrane. (M-8720/2). http://purl.obolibrary.org/obo/MPATH_361 naevus http://purl.obolibrary.org/obo/MPATH_358 melanocytic tumor Local lesion of the skin, often colored by hyperpigmentation or increased vascularity. May be predominantly epidermal, adnexal, melanocytic, vascular, or mesodermal, or a compound overgrowth of these tissues. Not necessarily pre-malignant. (M-8720/0). http://purl.obolibrary.org/obo/MPATH_365 mesothelioma http://purl.obolibrary.org/obo/MPATH_218 neoplasm Benign or malignant neoplasm derived from the lining cells of the pleura and peritoneum, composed of spindle cells or fibrous tissue which may enclose glandlike spaces lined by cuboidal cells. Epithelioid, fibrous, cystis, papillary, and sarcomatoid variants. (M- 9050/3). http://purl.obolibrary.org/obo/MPATH_366 neuroendocrine tumor http://purl.obolibrary.org/obo/MPATH_218 neoplasm Neoplasms derived from the neuroendocrine system. http://purl.obolibrary.org/obo/MPATH_370 primitive neurectodermal tumor http://purl.obolibrary.org/obo/MPATH_570 peripheral nervous system tumors Primitive neuroectodermal tumors (PNET) are neoplasms derived from primitive neural stem cells either in the CNS or the periphery . These are small-cell, malignant embryonal tumors showing divergent differentiation of variable degree along neuronal, glial, or rarely mesenchymal lines. (M-9473/3, M-9364/3). http://purl.obolibrary.org/obo/MPATH_371 small cell carcinoma http://purl.obolibrary.org/obo/MPATH_549 carcinoma Neuroendocrine cell derived anaplastic carcinoma composed of small cells, usually of the lung producing a variety of peptide hormones. (M-8041/3). 1.2.3.4 of MMHCC classification. http://purl.obolibrary.org/obo/MPATH_375 ganglioneuroma http://purl.obolibrary.org/obo/MPATH_570 peripheral nervous system tumors A benign neoplasm composed of mature ganglionic neurons scattered singly or in clumps within a relatively abundant and dense stroma of neurofibrils and collagenous fibers. (M-9490/0). http://purl.obolibrary.org/obo/MPATH_376 neuroblastoma http://purl.obolibrary.org/obo/MPATH_373 CNS progenitor tumor A malignant neoplasm characterized by immature, poorly differentiated nerve cells of embryonic type. (M-9500/3). http://purl.obolibrary.org/obo/MPATH_377 pheochromocytoma http://purl.obolibrary.org/obo/MPATH_366 neuroendocrine tumor A catecholamine-secreting tumor arising from the chromaffin cells of the sympathetic nervous system or adrenal medulla. May be benign or malignant. [See MPATH 398]. (M- 8510/3). http://purl.obolibrary.org/obo/MPATH_378 retinoblastoma http://purl.obolibrary.org/obo/MPATH_373 CNS progenitor tumor Malignant juvenile neoplasm of the eye derived from primitive retinal precursor cells. (M- 9510/3). http://purl.obolibrary.org/obo/MPATH_379 odontogenic tumor http://purl.obolibrary.org/obo/MPATH_218 neoplasm Neoplasm arising from the tissues of the odontogenic apparatus. These tumors are derived from ectodermal tissue (epithelial tumors) or from mesodermal tissue (connective tissue tumors) or are composed of both components (mixed or composite odontogenic tumors) . http://purl.obolibrary.org/obo/MPATH_388 osseous and chondromatous tumor http://purl.obolibrary.org/obo/MPATH_218 neoplasm Neoplasms of bone and cartilage. http://purl.obolibrary.org/obo/MPATH_396 osteoma http://purl.obolibrary.org/obo/MPATH_388 osseous and chondromatous tumor Benign neoplasm derived from osteoblasts or osteocytes composed of very dense bone with predominantly woven structure. ( M-9180/0). http://purl.obolibrary.org/obo/MPATH_397 osteosarcoma http://purl.obolibrary.org/obo/MPATH_388 osseous and chondromatous tumor Malignant neoplasm derived form mesenchymal stem cells, osteoblasts or osteocytes. Highly invasive and destructive tumor rising in the skeleton with osteoid and immature woven bone. (M-9180/3). http://purl.obolibrary.org/obo/MPATH_398 paragangliomas and glomus tumor http://purl.obolibrary.org/obo/MPATH_366 neuroendocrine tumor Generally benign neoplasms of CHIEF cells arising from neuroectodermal tissues, found in various parts of the body. Note that until recently, glomus tumors were believed to be derived from specialised vascular cells, which is incorrect. Paraganglioma is the preferred term.The nomenclature for pheochromocytoma and paraganglioma is inconsistent. The term paraganglioma is used to refer to any extra-adrenal tumor of the paraganglion system or nonfunctional tumor of the paraganglion system. Functional tumors are referred extra-adrenal pheochromocytoma. http://purl.obolibrary.org/obo/MPATH_4 necrosis http://purl.obolibrary.org/obo/MPATH_2 cell death Morpholological changes after intravital (Pathologic) death of one or more cells, or of a portion of tissue or organ, resulting from irreversible damage;characterised by mitochondrial swelling, nuclear pyknosis, karyolysis, swollen and abnormally pale basophilic staining; or karyorrhexis, rupture and fragmentation of the nucleus. Energy independent cf. Apoptosis MPATH 3. http://purl.obolibrary.org/obo/MPATH_403 paraganglioma http://purl.obolibrary.org/obo/MPATH_398 paragangliomas and glomus tumor A neoplasm composed of derivatives of CHIEF cells usually in single encapsulated nodular masses surrounded with sustentacular cells. ( M- 8711/0). http://purl.obolibrary.org/obo/MPATH_404 soft tissue tumor http://purl.obolibrary.org/obo/MPATH_218 neoplasm Neoplasms of the soft and connective tissues. http://purl.obolibrary.org/obo/MPATH_405 chordoma http://purl.obolibrary.org/obo/MPATH_404 soft tissue tumor Believed to arise from primitive notochord remnants . Usually occurs along the axial skeleton and is characterised by the presence of bubble cells containing large unstained cytoplasmic vacuoles with central or eccentricc nuclei. Benign but locally invasive. (M-9370/3). http://purl.obolibrary.org/obo/MPATH_407 fibroma http://purl.obolibrary.org/obo/MPATH_551 sarcoma Benign neoplasm of fibroblasts/fibrocytes with poor/moderate cellularity. (M-8810/0). http://purl.obolibrary.org/obo/MPATH_408 soft tissue fibrosarcoma http://purl.obolibrary.org/obo/MPATH_551 sarcoma Malignant tumor derived from pluripotential mesenchymal stem cells; fibroblasts, fibrocytes (M-8810/3). http://purl.obolibrary.org/obo/MPATH_415 lipomatous tumor http://purl.obolibrary.org/obo/MPATH_404 soft tissue tumor Tumors derived from the lipogenic lineage or showing predominantly lipomatous differentiation. http://purl.obolibrary.org/obo/MPATH_416 angiomyolipoma http://purl.obolibrary.org/obo/MPATH_415 lipomatous tumor Benign renal neoplasm composed of fat, vascular, and smooth muscle elements. Associated with tuberous sclerosis in humans. Aetiology unknown, but the combination of elements may reflect a lesion specific pattern of metaplasia. (M-8860/0). http://purl.obolibrary.org/obo/MPATH_417 lipoma http://purl.obolibrary.org/obo/MPATH_415 lipomatous tumor Benign neoplasia derived from lipoblasts or lipocytes of white or brown fat. May be angiomatous or hibernomatous. (M- 8850/0). http://purl.obolibrary.org/obo/MPATH_419 lymphatic vessel tumor http://purl.obolibrary.org/obo/MPATH_404 soft tissue tumor Neoplasms of the lymphatic vessels. http://purl.obolibrary.org/obo/MPATH_420 lymphangioma http://purl.obolibrary.org/obo/MPATH_419 lymphatic vessel tumor Benign hamartomatous malformation of the lymphatic ducts. Usually found in the skin and may be superficial or deep. (M-9170/0). http://purl.obolibrary.org/obo/MPATH_423 myomatous tumor http://purl.obolibrary.org/obo/MPATH_404 soft tissue tumor Neoplasms derived from myogenic lineages or predominantly composed of cells showing myomatous differentiation. http://purl.obolibrary.org/obo/MPATH_425 leiomyoma http://purl.obolibrary.org/obo/MPATH_423 myomatous tumor Benign neoplasm derived from smooth muscle cells. (M-8890/0). http://purl.obolibrary.org/obo/MPATH_426 leiomyosarcoma http://purl.obolibrary.org/obo/MPATH_551 sarcoma Malignant tumor derived form pluripotential mesenchymal stem cells or smooth muscle cells. (M- 8890/3). http://purl.obolibrary.org/obo/MPATH_428 rhabdomyosarcoma http://purl.obolibrary.org/obo/MPATH_551 sarcoma Malignant tumor of striated muscle or pluripotential mesenchymal stem cells. (M-8900/3). http://purl.obolibrary.org/obo/MPATH_431 myxoma http://purl.obolibrary.org/obo/MPATH_429 myxomatous tumor A benign neoplasm derived from pluripotential mesenchymal stem cells of connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix. May show multiple differentiated components. (M-8840/0). http://purl.obolibrary.org/obo/MPATH_433 nerve sheath tumor http://purl.obolibrary.org/obo/MPATH_570 peripheral nervous system tumors Neoplasms of the nerve sheath. http://purl.obolibrary.org/obo/MPATH_435 neurofibroma http://purl.obolibrary.org/obo/MPATH_433 nerve sheath tumor Peripheral nerve tumor consisting of chaotic arrays of wavy schwann cell bundles and fibroblasts interspersed within a matrix rich in collagen and mucopolysaccharide. (M9540/0). http://purl.obolibrary.org/obo/MPATH_437 neurofibrosarcoma http://purl.obolibrary.org/obo/MPATH_551 sarcoma Malignant neoplasm derived from Schwann cells. (M-9540/3). http://purl.obolibrary.org/obo/MPATH_438 schwannoma http://purl.obolibrary.org/obo/MPATH_433 nerve sheath tumor May be malignant or benign, Schwann cell derived tumor considered to be neurectodermal with some acquired mesenchymal features. (M-9560/0). http://purl.obolibrary.org/obo/MPATH_442 squamous cell tumor http://purl.obolibrary.org/obo/MPATH_218 neoplasm Neoplasms of stratified squamous epithelial cells. http://purl.obolibrary.org/obo/MPATH_445 papilloma http://purl.obolibrary.org/obo/MPATH_556 potentially cancerous lesions A benign tumor consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells (M-8050/0). http://purl.obolibrary.org/obo/MPATH_446 squamous cell carcinoma http://purl.obolibrary.org/obo/MPATH_549 carcinoma Malignant tumor derived from stratified squamous cells. (M-8070/3). http://purl.obolibrary.org/obo/MPATH_450 transitional cell tumor http://purl.obolibrary.org/obo/MPATH_218 neoplasm Neoplasms of transitional epithelia, eg kidney, ureter , bladder , cervix. http://purl.obolibrary.org/obo/MPATH_451 transitional cell carcinoma http://purl.obolibrary.org/obo/MPATH_549 carcinoma Malignant neoplasm of transitional cells (M-8120/3). http://purl.obolibrary.org/obo/MPATH_474 ectasia http://purl.obolibrary.org/obo/MPATH_66 dilatation Dilation of a tubular structure. http://purl.obolibrary.org/obo/MPATH_490 adenomatous polyp http://purl.obolibrary.org/obo/MPATH_270 adenoma Benign neoplastic growth containing areas of adenomatous structure (progression). http://purl.obolibrary.org/obo/MPATH_496 Non-Lymphoid leukaemias http://purl.obolibrary.org/obo/MPATH_515 non-Lymphoid neoplasias Neoplasms of non-lymphoid haematopoietic lineage. Must have at least 20% blast cells to meet this definition. http://purl.obolibrary.org/obo/MPATH_504 non-lymphoid hematopoietic sarcomas http://purl.obolibrary.org/obo/MPATH_551 sarcoma Solid tumor mass composed of non-lymphoid haematopoietic cells. http://purl.obolibrary.org/obo/MPATH_506 histiocytic sarcoma http://purl.obolibrary.org/obo/MPATH_504 non-lymphoid hematopoietic sarcomas Solid tumor mass composed predominantly of histiocytic cells (M-9775/3). http://purl.obolibrary.org/obo/MPATH_513 lymphoid neoplasms http://purl.obolibrary.org/obo/MPATH_335 hematopoietic/lymphoid malignancies/disorder Neoplasms of the B or T cell lineage. http://purl.obolibrary.org/obo/MPATH_515 non-Lymphoid neoplasias http://purl.obolibrary.org/obo/MPATH_335 hematopoietic/lymphoid malignancies/disorder Hematological neoplasias of non-lymphoid origin. http://purl.obolibrary.org/obo/MPATH_516 B-cell neoplasms http://purl.obolibrary.org/obo/MPATH_513 lymphoid neoplasms Neoplasm of the B cell lymphoid lineage. http://purl.obolibrary.org/obo/MPATH_519 mature B-cell neoplasms http://purl.obolibrary.org/obo/MPATH_516 B-cell neoplasms Lymphomas originating in peripheral B cells. http://purl.obolibrary.org/obo/MPATH_530 plasma cell neoplasms http://purl.obolibrary.org/obo/MPATH_516 B-cell neoplasms Diffuse proliferation of mature plasma cells. Clonal by definition. Includes the equivalent of human myeloma (ICD-O 9732/3). http://purl.obolibrary.org/obo/MPATH_532 plasmacytoma http://purl.obolibrary.org/obo/MPATH_530 plasma cell neoplasms Diffuse proliferation of mature plasma cells. Clonal by definition. http://purl.obolibrary.org/obo/MPATH_535 T-cell neoplasms http://purl.obolibrary.org/obo/MPATH_513 lymphoid neoplasms Neoplasms derived from cells of the T lymphocyte lineage. http://purl.obolibrary.org/obo/MPATH_536 precursor T-cell neoplasms http://purl.obolibrary.org/obo/MPATH_535 T-cell neoplasms Neoplasms of precursor T cells. http://purl.obolibrary.org/obo/MPATH_537 precursor T-cell lymphoblastic lymphoma/leukaemia http://purl.obolibrary.org/obo/MPATH_536 precursor T-cell neoplasms Precursor T cell derived neoplasia. Most commonly found in the thymus. http://purl.obolibrary.org/obo/MPATH_549 carcinoma http://purl.obolibrary.org/obo/MPATH_218 neoplasm Any of various types of malignant neoplasm derived from epithelial cells, chiefly glandular (adenocarcinoma) or squamous (squamous cell carcinoma). http://purl.obolibrary.org/obo/MPATH_55 developmental and structural abnormality http://purl.obolibrary.org/obo/MPATH_603 pathological anatomical entity Developmental and structural abnormalities occurring during embryonic development or during adult life. http://purl.obolibrary.org/obo/MPATH_551 sarcoma http://purl.obolibrary.org/obo/MPATH_218 neoplasm A connective tissue neoplasm, usually highly malignant, formed by proliferation of mesodermal cells. http://purl.obolibrary.org/obo/MPATH_555 mineralisation http://purl.obolibrary.org/obo/MPATH_33 intracellular and extracellular accumulation Deposition of any homogeneous inorganic material. http://purl.obolibrary.org/obo/MPATH_556 potentially cancerous lesions http://purl.obolibrary.org/obo/MPATH_218 neoplasm Lesions which in some cases have the potential to become progressively growing malignant tumors. http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect http://purl.obolibrary.org/obo/MPATH_55 developmental and structural abnormality Structural, physical or other general defect of prenatal development of the embryo and the placenta, or such as are acquired in the adult. http://purl.obolibrary.org/obo/MPATH_564 glioblastoma http://purl.obolibrary.org/obo/MPATH_249 glioma Develop primarily through increasing anaplasia of well differentiated gliomas, mainly astrocytomas or oligodendrogliomas. Typically large and contain cells of different sizes with irrregular nuclei and atypical mitotic figures. (M-9440/3). http://purl.obolibrary.org/obo/MPATH_565 tumors of neurepithelial tissue http://purl.obolibrary.org/obo/MPATH_243 central nervous system tumor Tumors of neuronal and non-neuronal cells derived from embryonic neurepithelium. http://purl.obolibrary.org/obo/MPATH_566 tumors of the meninges http://purl.obolibrary.org/obo/MPATH_243 central nervous system tumor tumors of the meninges http://purl.obolibrary.org/obo/MPATH_570 peripheral nervous system tumors http://purl.obolibrary.org/obo/MPATH_218 neoplasm Tumors of the peripheral nervous system. http://purl.obolibrary.org/obo/MPATH_571 pilomatricoma http://purl.obolibrary.org/obo/MPATH_575 basaloid follicular neoplasms Tumor composed of the epithelial components of the most proximal (trichogenic) portion of the hair follicle associated with an aberrent hair cortex type of cornification (ghost cells or shadow cells). The most primitive cellular component consists of basophilic cells having scanty cytoplasm and nuclei that occasionally overlap to some extent. In humans mineralisation is common. http://purl.obolibrary.org/obo/MPATH_575 basaloid follicular neoplasms http://purl.obolibrary.org/obo/MPATH_219 adnexal and skin appendage tumor This is a new diagnostic term that the MMHC pathology panel felt best described a diagnostically challenging set of tumors that share the feature of being compose of basaloid cells showing follicular differentiation to some extent. These tumors are common in GEM involving the hedgehog signaling pathway and frequently have more than one of the histologic patterns listed below. The designation of benign and malignant has been excluded from the primary diagnosis purposely, as this is frequently difficult to determine in these characteristically well circumscribed tumors. The presence of a disorganized (non-palisaded) sheet-like growth pattern, tumor necrosis, or numerous mitoses are felt to represent malignant transformation. http://purl.obolibrary.org/obo/MPATH_576 trichofolliculoma http://purl.obolibrary.org/obo/MPATH_575 basaloid follicular neoplasms Basaloid neoplasm with numerous mature hair follicles and hair formation. http://purl.obolibrary.org/obo/MPATH_596 pathological process http://purl.obolibrary.org/obo/MPATH_0 pathological entity The organic response of tissues to external insult, injury or underlying genetic or epigenetic lesion. http://purl.obolibrary.org/obo/MPATH_597 cell and tissue damage process http://purl.obolibrary.org/obo/MPATH_596 pathological process Processes occurring during cell and tissue damage of either intrinsic or extrinsic etiology. http://purl.obolibrary.org/obo/MPATH_599 developmental process abnormalities http://purl.obolibrary.org/obo/MPATH_596 pathological process developmental process abnormalities http://purl.obolibrary.org/obo/MPATH_602 hyperplastic tissue http://purl.obolibrary.org/obo/MPATH_126 growth and differentiation defect An organ or a tissue with an abnormal increase in the number of cells as a consequence of cell proliferation. http://purl.obolibrary.org/obo/MPATH_603 pathological anatomical entity http://purl.obolibrary.org/obo/MPATH_0 pathological entity Anatomically located instance of pathological response or entity. http://purl.obolibrary.org/obo/MPATH_604 defective growth and differentiation process http://purl.obolibrary.org/obo/MPATH_596 pathological process Abnormal increase or decrease in the rate of cell growth or cell division including associated changes in the differentiation state of adult cells. http://purl.obolibrary.org/obo/MPATH_605 metaplastic tissue http://purl.obolibrary.org/obo/MPATH_126 growth and differentiation defect A tissue or group of cells in which there has been abnormal transformation of an fully differentiated adult cell or tissue of one kind into a differentiated tissue of another kind. http://purl.obolibrary.org/obo/MPATH_607 healing and repair structure http://purl.obolibrary.org/obo/MPATH_603 pathological anatomical entity Physical entity or structure associated with normal or abnormal tissue healing or repair following extrinsic or intrinsic damage. http://purl.obolibrary.org/obo/MPATH_625 avulsion http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect Tearing away or separation of two structures or parts. http://purl.obolibrary.org/obo/MPATH_629 cavernous hemangioma http://purl.obolibrary.org/obo/MPATH_240 hemangioma Deep cutaneous hemangioma with large dilated vascular spaces that manifests spontaneous involution. http://purl.obolibrary.org/obo/MPATH_64 developmental dysplasia http://purl.obolibrary.org/obo/MPATH_599 developmental process abnormalities Abnormal development (of organs or tissues) or an abnormal structure resulting from such growth. http://purl.obolibrary.org/obo/MPATH_66 dilatation http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect Increase in the diameter of an orifice or tubular structure beyond its normal dimensions. http://purl.obolibrary.org/obo/MPATH_709 alveolar rhabdomyosarcoma http://purl.obolibrary.org/obo/MPATH_428 rhabdomyosarcoma Malignant tumor of striated muscle or pluripotential mesenchymal stem cells composed mainly of small round cells, with some partial skeletal muscle differentiation. http://purl.obolibrary.org/obo/MPATH_710 embryonal rhabdomyosarcoma http://purl.obolibrary.org/obo/MPATH_428 rhabdomyosarcoma Malignant mesenchymal tumor that morphologically and phenotypically resembles embryonal skeletal muscle. http://purl.obolibrary.org/obo/MPATH_722 rhabdomyoma http://purl.obolibrary.org/obo/MPATH_423 myomatous tumor Benign stromal tumors of the soft tissue with skeletal muscle differentiation. http://purl.obolibrary.org/obo/MPATH_723 fibromatosis http://purl.obolibrary.org/obo/MPATH_407 fibroma Systemic manifestation of MPATH: 407. http://purl.obolibrary.org/obo/MPATH_81 perforation http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect Presence of a hole/channel through a normally imperforate structure often a membrane or septum. http://purl.obolibrary.org/obo/MPATH_850 post-traumatic structural abnormality http://purl.obolibrary.org/obo/MPATH_56 developmental or adult structural defect Morphological abnormality following trauma or related insult such as infection. http://purl.obolibrary.org/obo/MPATH_851 auricular deformation http://purl.obolibrary.org/obo/MPATH_850 post-traumatic structural abnormality acquired dysmorphology of the external pinna following trauma or infection. http://purl.obolibrary.org/obo/MPATH_86 organ specific developmental defect http://purl.obolibrary.org/obo/MPATH_55 developmental and structural abnormality Developmental defect characteristic of a particular organ or organ system which may be a recognised syndrome or a complex defect showing multiple manifestations. http://purl.obolibrary.org/obo/MPATH_89 cardiovascular developmental defect http://purl.obolibrary.org/obo/MPATH_86 organ specific developmental defect Abnormal development of the heart or vascular tissue resulting in morphological abnormality. http://purl.obolibrary.org/obo/MPATH_97 dissecting aneurysm http://purl.obolibrary.org/obo/MPATH_90 aneurysm Follows the presence of a hematoma in the wall of an artery Splitting of the media occurs, blood enters the split through a tear in the intima. http://purl.obolibrary.org/obo/MPATH_534 anaplastic plasmacytoma http://purl.obolibrary.org/obo/MPATH_532 plasmacytoma Diffuse proliferation of immature plasma cells or plasma blasts. http://purl.obolibrary.org/obo/MPATH_249 glioma http://purl.obolibrary.org/obo/MPATH_565 tumors of neurepithelial tissue Neoplasm derived from astrocytes and oligodendrocytes. (M-9380/3, M-9440/3). http://purl.obolibrary.org/obo/MPATH_770 abnormal organ size http://purl.obolibrary.org/obo/MPATH_86 organ specific developmental defect Abnormal organ dimensions or weight http://purl.obolibrary.org/obo/MPATH_738 uterine cystic endometrial hyperplasia http://purl.obolibrary.org/obo/MPATH_134 hyperplasia http://purl.obolibrary.org/obo/MPATH_716 ciliary motility defect http://purl.obolibrary.org/obo/MPATH_17 subcellular defect http://purl.obolibrary.org/obo/MPATH_664 granulomatous peritonitis http://purl.obolibrary.org/obo/MPATH_663 peritonitis http://purl.obolibrary.org/obo/MPATH_665 foreign body granulomatous peritonitis http://purl.obolibrary.org/obo/MPATH_663 peritonitis http://purl.obolibrary.org/obo/MPATH_697 alopecia areata http://purl.obolibrary.org/obo/MPATH_26 alopecia http://purl.obolibrary.org/obo/MPATH_726 hemosiderosis http://purl.obolibrary.org/obo/MPATH_41 iron deposition http://purl.obolibrary.org/obo/MPATH_729 splenic melanosis http://purl.obolibrary.org/obo/MPATH_44 melanin deposition http://purl.obolibrary.org/obo/MPATH_711 situs ambiguus http://purl.obolibrary.org/obo/MPATH_470 left/right axis defect http://purl.obolibrary.org/obo/MPATH_712 heterotaxy http://purl.obolibrary.org/obo/MPATH_470 left/right axis defect http://purl.obolibrary.org/obo/MPATH_720 situs inversus http://purl.obolibrary.org/obo/MPATH_470 left/right axis defect http://purl.obolibrary.org/obo/MPATH_692 ulcerative blepharitis http://purl.obolibrary.org/obo/MPATH_546 blepharitis http://purl.obolibrary.org/obo/MPATH_734 acute blepharitis http://purl.obolibrary.org/obo/MPATH_546 blepharitis http://purl.obolibrary.org/obo/MPATH_651 ventral glossitis http://purl.obolibrary.org/obo/MPATH_611 glossitis http://purl.obolibrary.org/obo/MPATH_662 foreign body glossitis http://purl.obolibrary.org/obo/MPATH_611 glossitis http://purl.obolibrary.org/obo/MPATH_730 renal tubular concretion http://purl.obolibrary.org/obo/MPATH_614 concretion http://purl.obolibrary.org/obo/MPATH_725 chronic interstitial nephritis http://purl.obolibrary.org/obo/MPATH_647 interstitial nephritis http://purl.obolibrary.org/obo/MPATH_653 langerhans cell histiocytosis http://purl.obolibrary.org/obo/MPATH_652 histiocytosis http://purl.obolibrary.org/obo/MPATH_654 non-Langerhans cell histiocytosis http://purl.obolibrary.org/obo/MPATH_652 histiocytosis http://purl.obolibrary.org/obo/MPATH_818 focal pulmonary histiocytosis http://purl.obolibrary.org/obo/MPATH_652 histiocytosis http://purl.obolibrary.org/obo/MPATH_684 arthropathy http://purl.obolibrary.org/obo/MPATH_25 tissue specific degenerative process http://purl.obolibrary.org/obo/MPATH_658 foreign body rhinitis http://purl.obolibrary.org/obo/MPATH_657 rhinitis http://purl.obolibrary.org/obo/MPATH_661 foreign body gastritis http://purl.obolibrary.org/obo/MPATH_660 gastritis http://purl.obolibrary.org/obo/MPATH_667 foreign body periodontitis http://purl.obolibrary.org/obo/MPATH_666 periodontitis http://purl.obolibrary.org/obo/MPATH_669 foreign body tracheitis http://purl.obolibrary.org/obo/MPATH_668 tracheitis http://purl.obolibrary.org/obo/MPATH_686 amputation http://purl.obolibrary.org/obo/MPATH_67 displacement and deformity http://purl.obolibrary.org/obo/MPATH_693 pyometra http://purl.obolibrary.org/obo/MPATH_673 metritis http://purl.obolibrary.org/obo/MPATH_647 interstitial nephritis http://purl.obolibrary.org/obo/MPATH_212 inflammation http://purl.obolibrary.org/obo/MPATH_677 pyelonephritis http://purl.obolibrary.org/obo/MPATH_676 nephritis http://purl.obolibrary.org/obo/MPATH_678 septic nephritis http://purl.obolibrary.org/obo/MPATH_676 nephritis http://purl.obolibrary.org/obo/MPATH_680 septic urocystitis http://purl.obolibrary.org/obo/MPATH_679 urocystitis http://purl.obolibrary.org/obo/MPATH_683 degenerative arthritis http://purl.obolibrary.org/obo/MPATH_25 tissue specific degenerative process http://purl.obolibrary.org/obo/MPATH_687 autoamputation http://purl.obolibrary.org/obo/MPATH_686 amputation http://purl.obolibrary.org/obo/MPATH_699 ankylosing exostosis http://purl.obolibrary.org/obo/MPATH_698 exostosis http://purl.obolibrary.org/obo/MPATH_713 situs ambiguus totalis http://purl.obolibrary.org/obo/MPATH_720 situs inversus http://purl.obolibrary.org/obo/MPATH_714 situs inversus with levocardia http://purl.obolibrary.org/obo/MPATH_720 situs inversus http://purl.obolibrary.org/obo/MPATH_727 hepatic hemosiderosis http://purl.obolibrary.org/obo/MPATH_726 hemosiderosis http://purl.obolibrary.org/obo/MPATH_728 pulmonary hemosiderosis http://purl.obolibrary.org/obo/MPATH_726 hemosiderosis http://purl.obolibrary.org/obo/MPATH_701 developmental aspermia http://purl.obolibrary.org/obo/MPATH_599 developmental process abnormalities http://purl.obolibrary.org/obo/MPATH_702 acquired aspermia http://purl.obolibrary.org/obo/MPATH_796 aspermia http://purl.obolibrary.org/obo/MPATH_685 accessory organ http://purl.obolibrary.org/obo/MPATH_84 supernumerary structure http://purl.obolibrary.org/obo/MPATH_682 arteritis http://purl.obolibrary.org/obo/MPATH_201 vasculitis http://purl.obolibrary.org/obo/MPATH_688 aortitis http://purl.obolibrary.org/obo/MPATH_201 vasculitis http://purl.obolibrary.org/obo/MPATH_689 lymphangitis http://purl.obolibrary.org/obo/MPATH_201 vasculitis http://purl.obolibrary.org/obo/MPATH_690 phlebitis http://purl.obolibrary.org/obo/MPATH_201 vasculitis http://purl.obolibrary.org/obo/MPATH_691 pustule http://purl.obolibrary.org/obo/MPATH_608 abscess http://purl.obolibrary.org/obo/MPATH_736 ovarian follicular cyst http://purl.obolibrary.org/obo/MPATH_62 cyst http://purl.obolibrary.org/obo/MPATH_717 sequestrum http://purl.obolibrary.org/obo/MPATH_1 cell and tissue damage http://purl.obolibrary.org/obo/MPATH_698 exostosis http://purl.obolibrary.org/obo/MPATH_126 growth and differentiation defect http://purl.obolibrary.org/obo/MPATH_705 acinar atrophy http://purl.obolibrary.org/obo/MPATH_127 atrophy http://purl.obolibrary.org/obo/MPATH_346 autoimmune mediated disease http://purl.obolibrary.org/obo/MPATH_194 immune mediated disease http://purl.obolibrary.org/obo/MPATH_659 foreign body dermatitis http://purl.obolibrary.org/obo/MPATH_196 dermatitis http://purl.obolibrary.org/obo/MPATH_675 psoriasiform dermatitis http://purl.obolibrary.org/obo/MPATH_196 dermatitis http://purl.obolibrary.org/obo/MPATH_546 blepharitis http://purl.obolibrary.org/obo/MPATH_212 inflammation http://purl.obolibrary.org/obo/MPATH_645 epicarditis http://purl.obolibrary.org/obo/MPATH_212 inflammation http://purl.obolibrary.org/obo/MPATH_646 chondroarthritis http://purl.obolibrary.org/obo/MPATH_212 inflammation http://purl.obolibrary.org/obo/MPATH_648 interstitial pancreatitis http://purl.obolibrary.org/obo/MPATH_212 inflammation http://purl.obolibrary.org/obo/MPATH_649 otitis media http://purl.obolibrary.org/obo/MPATH_212 inflammation http://purl.obolibrary.org/obo/MPATH_650 proliferative dermatitis http://purl.obolibrary.org/obo/MPATH_212 inflammation http://purl.obolibrary.org/obo/MPATH_655 lingual adenitis http://purl.obolibrary.org/obo/MPATH_212 inflammation http://purl.obolibrary.org/obo/MPATH_657 rhinitis http://purl.obolibrary.org/obo/MPATH_212 inflammation http://purl.obolibrary.org/obo/MPATH_660 gastritis http://purl.obolibrary.org/obo/MPATH_212 inflammation http://purl.obolibrary.org/obo/MPATH_663 peritonitis http://purl.obolibrary.org/obo/MPATH_212 inflammation http://purl.obolibrary.org/obo/MPATH_666 periodontitis http://purl.obolibrary.org/obo/MPATH_212 inflammation http://purl.obolibrary.org/obo/MPATH_668 tracheitis http://purl.obolibrary.org/obo/MPATH_212 inflammation http://purl.obolibrary.org/obo/MPATH_671 mastitis http://purl.obolibrary.org/obo/MPATH_212 inflammation http://purl.obolibrary.org/obo/MPATH_672 mastocytosis http://purl.obolibrary.org/obo/MPATH_212 inflammation http://purl.obolibrary.org/obo/MPATH_673 metritis http://purl.obolibrary.org/obo/MPATH_212 inflammation http://purl.obolibrary.org/obo/MPATH_674 osteomyelitis http://purl.obolibrary.org/obo/MPATH_212 inflammation http://purl.obolibrary.org/obo/MPATH_676 nephritis http://purl.obolibrary.org/obo/MPATH_212 inflammation http://purl.obolibrary.org/obo/MPATH_679 urocystitis http://purl.obolibrary.org/obo/MPATH_212 inflammation http://purl.obolibrary.org/obo/MPATH_681 septicemia http://purl.obolibrary.org/obo/MPATH_212 inflammation http://purl.obolibrary.org/obo/MPATH_704 thyroiditis http://purl.obolibrary.org/obo/MPATH_212 inflammation http://purl.obolibrary.org/obo/MPATH_715 sinusitis http://purl.obolibrary.org/obo/MPATH_212 inflammation http://purl.obolibrary.org/obo/MPATH_737 retinal degeneration http://purl.obolibrary.org/obo/MPATH_25 tissue specific degenerative process http://purl.obolibrary.org/obo/MPATH_694 acidophilic anterior pituitary gland adenoma http://purl.obolibrary.org/obo/MPATH_270 adenoma http://purl.obolibrary.org/obo/MPATH_700 ascites http://purl.obolibrary.org/obo/MPATH_33 intracellular and extracellular accumulation http://purl.obolibrary.org/obo/MPATH_707 angiolipoma http://purl.obolibrary.org/obo/MPATH_415 lipomatous tumor http://purl.obolibrary.org/obo/MPATH_719 bronchiectasia http://purl.obolibrary.org/obo/MPATH_474 ectasia http://purl.obolibrary.org/obo/MPATH_732 tracheal gland ectasia http://purl.obolibrary.org/obo/MPATH_474 ectasia http://purl.obolibrary.org/obo/MPATH_695 spindle cell sarcoma http://purl.obolibrary.org/obo/MPATH_551 sarcoma http://purl.obolibrary.org/obo/MPATH_819 focal renal pelvic mineralisation. http://purl.obolibrary.org/obo/MPATH_555 mineralisation http://purl.obolibrary.org/obo/MPATH_703 developmental hypoplasia http://purl.obolibrary.org/obo/MPATH_599 developmental process abnormalities http://purl.obolibrary.org/obo/MPATH_696 spindle cell hyperplasia http://purl.obolibrary.org/obo/MPATH_602 hyperplastic tissue http://purl.obolibrary.org/obo/MPATH_731 Leydig cell hyperplasia http://purl.obolibrary.org/obo/MPATH_602 hyperplastic tissue http://purl.obolibrary.org/obo/MPATH_706 cryptorchidism http://purl.obolibrary.org/obo/MPATH_86 organ specific developmental defect http://purl.obolibrary.org/obo/MPATH_1000 pathological phenotype observation Phenotypic observation of the presence or absence of a pathological entity. http://purl.obolibrary.org/obo/MPATH_129 epithelial dysplasia epithelial dysplasia http://purl.obolibrary.org/obo/MPATH_203 general immunodeficiency disease general immunodeficiency disease http://purl.obolibrary.org/obo/MPATH_204 chronic/recurrent inflammatory disease chronic/recurrent inflammatory disease http://purl.obolibrary.org/obo/MPATH_205 immunodeficiency associated infection Infection with bacteria, viruses or fungi subsequent to immunodeficiency. http://purl.obolibrary.org/obo/MPATH_217 ulcerative inflammation Combination of inflammation, often suppurative or granulomatous, with ulceration. http://purl.obolibrary.org/obo/MPATH_239 hemangioendothelioma hemangioendothelioma http://purl.obolibrary.org/obo/MPATH_248 ependymoma malignant ependymoma malignant http://purl.obolibrary.org/obo/MPATH_283 intraductal carcinoma In situ carcinoma of the mammary ductal epithelium. (M- 8500/2). http://purl.obolibrary.org/obo/MPATH_324 androblastoma obsolete use Sertoli cell tumor MPATH: 331. http://purl.obolibrary.org/obo/MPATH_325 fibrothecoma obsolete use thecoma MPATH:334. http://purl.obolibrary.org/obo/MPATH_327 gynandroblastoma gynandroblastoma http://purl.obolibrary.org/obo/MPATH_333 sex cord tumor sex cord tumor http://purl.obolibrary.org/obo/MPATH_336 leukaemia leukaemia http://purl.obolibrary.org/obo/MPATH_338 granulocytic leukaemia granulocytic leukaemia http://purl.obolibrary.org/obo/MPATH_339 lymphatic leukaemia lymphatic leukaemia http://purl.obolibrary.org/obo/MPATH_343 lymphoma lymphoma http://purl.obolibrary.org/obo/MPATH_344 follicle center cell lymphoma follicle center cell lymphoma http://purl.obolibrary.org/obo/MPATH_345 immunoblastic lymphoma immunoblastic lymphoma http://purl.obolibrary.org/obo/MPATH_347 small lymphocytic lymphoma small lymphocytic lymphoma http://purl.obolibrary.org/obo/MPATH_348 thymic lymphoma thymic lymphoma http://purl.obolibrary.org/obo/MPATH_349 mast cell tumor mast cell tumor http://purl.obolibrary.org/obo/MPATH_350 mastocytoma mastocytoma http://purl.obolibrary.org/obo/MPATH_364 mesothelial tumor mesothelial tumor http://purl.obolibrary.org/obo/MPATH_368 endocrine adenocarcinoma obsolete. http://purl.obolibrary.org/obo/MPATH_369 endocrine adenoma endocrine adenoma http://purl.obolibrary.org/obo/MPATH_386 odontogenic tumor odontogenic tumor http://purl.obolibrary.org/obo/MPATH_390 chondroblastoma, malignant chondroblastoma, malignant http://purl.obolibrary.org/obo/MPATH_402 glomus tumor glomus tumor http://purl.obolibrary.org/obo/MPATH_411 granular cell tumor/alveolar sarcoma granular cell tumor/alveolar sarcoma http://purl.obolibrary.org/obo/MPATH_414 histiocytic sarcoma histiocytic sarcoma http://purl.obolibrary.org/obo/MPATH_427 myoblastoma myoblastoma http://purl.obolibrary.org/obo/MPATH_434 neurilemmoma neurilemmoma http://purl.obolibrary.org/obo/MPATH_441 synovioma synovioma http://purl.obolibrary.org/obo/MPATH_459 obsolete obsolete http://purl.obolibrary.org/obo/MPATH_481 pre-neoplastic lesions Lesions likely to result in progression to frank tumors, which may be classified as pre-neoplastic or pre-cancerous. http://purl.obolibrary.org/obo/MPATH_483 atypical hyperplasia Presence of localised areas within for example adenomas showing characteristics of neoplastic (tumor) progression, eg focal carcinoma. http://purl.obolibrary.org/obo/MPATH_485 carcinoma in situ May be used in some systems in preference to its synonyms to indicate lesion specific aprearances. A lesion characterised by changes of the type associated with invasive carcinoma, but physically bounded by the lining epithelium and without local invasion. http://purl.obolibrary.org/obo/MPATH_514 B cell neoplasms B cell neoplasms http://purl.obolibrary.org/obo/MPATH_550 sarcoma A connective tissue neoplasm, usually highly malignant, formed by proliferation of mesodermal cells. http://purl.obolibrary.org/obo/MPATH_552 Clara cell adenoma Benign tumor of the Clara cells of the bronchioalveolar epithelium. http://purl.obolibrary.org/obo/MPATH_557 aberrant crypt foci Sensu gastrointsestinal tract. visible microscopically in whole mount colonic tissue. One or more crypts larger than most, have a thickened layer of epithelial cells that stain more intensely with methylene blue. Some have a slit shaped luminal opening, and increased pericryptal space and are elevated from the focal plane of the microscope. ACF is not a histologic diagnosis. http://purl.obolibrary.org/obo/MPATH_569 granular cell tumor granular cell tumor http://purl.obolibrary.org/obo/MPATH_588 dysplasia Dysplasia http://purl.obolibrary.org/obo/MPATH_593 myeloma Plasma cell myeloma - (ICD-O 9732/3). http://purl.obolibrary.org/obo/MPATH_598 degenerative entity degenerative entity http://purl.obolibrary.org/obo/MPATH_612 Abscess A circumscribed collection of purulent exudate frequently associated with swelling and other signs of inflammation. http://purl.obolibrary.org/obo/MPATH_65 developmental hypoplasia Underdevelopment of an organ due to a decrease in the number of cells through failure to proliferate leading to lack of development. http://purl.obolibrary.org/obo/MPATH_69 ectopia ectopia http://purl.obolibrary.org/obo/MPATH_88 nephroblastomatosis nephroblastomatosis http://purl.obolibrary.org/obo/mpath#is_a is a http://purl.obolibrary.org/obo/mpath#part_of part of