Term IRI Term label Parent term IRI Parent term label Alternative term Definition http://purl.obolibrary.org/obo/OBI_0000198 biological replicate role http://purl.obolibrary.org/obo/OBI_0000220 reference subject role biological replicate a reference participant role realized by equivalent treatment of participants http://purl.obolibrary.org/obo/OBI_0000220 reference subject role http://purl.obolibrary.org/obo/OBI_0000097 participant under investigation role reference participant a reference subject role which inheres in an organism or entity of organismal origin so that the characteristics or responses of the participant playing the reference participant role are used for comparison or reference http://purl.obolibrary.org/obo/MPIO_0000000 medical context information http://purl.obolibrary.org/obo/IAO_0000030 information content entity modifying factors information An information content entity that is about factors known to affect the pharmacodynamics or pharmacokinetics of a drug. http://purl.obolibrary.org/obo/MPIO_0000008 recommended action for potential drug-drug interaction http://purl.obolibrary.org/obo/IAO_0000104 plan specification recommended action An information content entity that describes an evidence-based strategy that should be adopted to mitigate the potential clinical consequences of a drug-drug interaction. http://purl.obolibrary.org/obo/DIDEO_00000020 drug-drug interaction http://purl.obolibrary.org/obo/GO_0008150 biological_process DDI A biological process that results in a clinically meaningful change to the response of at least one co-administrated drug. http://purl.obolibrary.org/obo/DIDEO_00000125 drug-drug interaction effect http://purl.obolibrary.org/obo/GO_0008150 biological_process A biological process that is the result of a drug-drug interaction. http://purl.obolibrary.org/obo/OGMS_0000014 clinical finding http://purl.obolibrary.org/obo/IAO_0000027 data item A representation that is either the output of a clinical history taking or a physical examination or an image finding, or some combination thereof. http://purl.obolibrary.org/obo/APOLLO_SV_00000461 drug identifier http://purl.obolibrary.org/obo/IAO_0000030 information content entity An identifier that denotes a drug product. http://purl.obolibrary.org/obo/IAO_0000033 directive information entity http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity whose concretizations indicate to their bearer how to realize them in a process. http://purl.obolibrary.org/obo/IAO_0000078 curation status specification http://purl.obolibrary.org/obo/IAO_0000102 data about an ontology part The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value. http://purl.obolibrary.org/obo/IAO_0000102 data about an ontology part http://purl.obolibrary.org/obo/IAO_0000027 data item data about an ontology part is a data item about a part of an ontology, for example a term http://purl.obolibrary.org/obo/IAO_0000104 plan specification http://purl.obolibrary.org/obo/IAO_0000033 directive information entity A directive information entity with action specifications and objective specifications as parts that, when concretized, is realized in a process in which the bearer tries to achieve the objectives by taking the actions specified. http://purl.obolibrary.org/obo/IAO_0000109 measurement datum http://purl.obolibrary.org/obo/IAO_0000027 data item A measurement datum is an information content entity that is a recording of the output of a measurement such as produced by a device. http://purl.obolibrary.org/obo/IAO_0000225 obsolescence reason specification http://purl.obolibrary.org/obo/IAO_0000102 data about an ontology part The reason for which a term has been deprecated. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value. http://purl.obolibrary.org/obo/IAO_0000409 denotator type http://purl.obolibrary.org/obo/IAO_0000102 data about an ontology part A denotator type indicates how a term should be interpreted from an ontological perspective. http://purl.obolibrary.org/obo/OBI_0000252 cohort role http://purl.obolibrary.org/obo/OBI_0000198 biological replicate role a cohort role is a biological replicate role played by a group of study participants who share a common characteristic of interest to the study. http://purl.obolibrary.org/obo/OGMS_0000015 clinical history http://purl.obolibrary.org/obo/OGMS_0000014 clinical finding A series of statements representing health-relevant qualities of a patient and of a patient's family. http://purl.obolibrary.org/obo/APOLLO_SV_00000032 count http://purl.obolibrary.org/obo/IAO_0000109 measurement datum A measurement datum that is the output of counting. http://purl.obolibrary.org/obo/MPIO_0000002 clinical consequences information http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity that is about changes in the patient health status from baseline that can be observed or measured by a clinician or be reported by the patient. http://purl.obolibrary.org/obo/MPIO_0000003 information about clinical consequences suspected to be the result of a drug-drug interaction http://purl.obolibrary.org/obo/MPIO_0000002 clinical consequences information An information content entity that is about changes in patient health status from baseline that can be observed or measured by a clinician or reported by a patient and that may be the result of co-administration of two or more drugs that may interact. http://purl.obolibrary.org/obo/MPIO_0000004 suspected drug-drug interaction evidence http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity that provides support for or refutation of a drug-drug interaction statement. http://purl.obolibrary.org/obo/MPIO_0000005 mechanism of interaction information http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity that is about the process or processes by which a drug-drug interaction clinical consequence occurs http://purl.obolibrary.org/obo/MPIO_0000006 frequency of harm information http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity that mentions both the number of individuals within a cohort that are experience a clinically relevant DDI effect over a specified time period and the total number of individuals in the cohort. http://purl.obolibrary.org/obo/MPIO_0000007 frequency of exposure information http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity that mentions both the number of individuals within a cohort that are exposed to a drug-drug interaction over a specified time period and the total number of individuals in the cohort. http://purl.obolibrary.org/obo/MPIO_0000009 seriousness information http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity that reports the degree to which a clinical consequence of a drug-drug interaction results in harm determining the type and speed of clinician intervention needed. http://purl.obolibrary.org/obo/MPIO_0000010 severity information http://www.geneontology.org/formats/oboInOwl#ObsoleteClass Obsolete Class An information content entity about the intensity of a clinical consequence of a drug-drug interaction. http://purl.obolibrary.org/obo/MPIO_0000111 operational classification statement http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity that is about some risk management (http://purl.obolibrary.org/obo/ERO_0000715) that has as a specified input an instance of a potential drug-drug interaction (http://purl.obolibrary.org/obo/DIDEO_00000000). http://purl.obolibrary.org/obo/DIDEO_00000000 potential drug-drug interaction http://purl.obolibrary.org/obo/IAO_0000030 information content entity A potential drug-drug interaction (PDDI) is an information content entity that specifies the possibility of a drug-drug interaction based on either reasonable extrapolation about drug-drug interaction mechanisms or a data item created by clinical studies, clinical observation or physiological experiment. http://purl.obolibrary.org/obo/DIDEO_00000021 drug co-administration http://purl.obolibrary.org/obo/OBI_0000011 planned process A planned process of administering more than one drug to the same individual over a specific time interval. http://purl.obolibrary.org/obo/DIDEO_00000030 obsolete_drug-drug interaction effect http://www.geneontology.org/formats/oboInOwl#ObsoleteClass Obsolete Class An entity that is the result of a drug-drug interaction. http://purl.obolibrary.org/obo/DIDEO_00000053 evidence information content entity http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity that is used to support or refute an assertion. http://purl.obolibrary.org/obo/APOLLO_SV_00000033 counting http://purl.obolibrary.org/obo/OBI_0000011 planned process The planned process of finding the number of elements in a finite set of objects. http://purl.obolibrary.org/obo/DIDEO_00000128 drug concept set identifier http://purl.obolibrary.org/obo/IAO_0000030 information content entity An identifier that denotes a set of drug identifiers. http://purl.obolibrary.org/obo/DINTO_000027 clinically relevant DDI effect http://purl.obolibrary.org/obo/DIDEO_00000125 drug-drug interaction effect http://purl.obolibrary.org/obo/IAO_0000030 information content entity http://purl.obolibrary.org/obo/BFO_0000031 generically dependent continuant http://purl.obolibrary.org/obo/IAO_0000027 data item http://purl.obolibrary.org/obo/IAO_0000030 information content entity http://purl.obolibrary.org/obo/PCO_0000000 collection of organisms organism collection A material entity that consists of two or more organisms, viruses, or viroids. http://purl.obolibrary.org/obo/OBI_0000011 planned process A processual entity that realizes a plan which is the concretization of a plan specification. http://purl.obolibrary.org/obo/OBI_0000097 participant under investigation role A role that is realized through the execution of a study design in which the bearer of the role participates and in which data about that bearer is collected. http://purl.obolibrary.org/obo/OBI_0100026 organism A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs. http://purl.obolibrary.org/obo/DRON_00000001 clinical drug role the role of a material entity to prevent, diagnose, treat, or study disease and/or its effects http://purl.obolibrary.org/obo/GO_0008150 biological_process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end. http://purl.obolibrary.org/obo/DINTO_000003 DDI mechanism http://purl.obolibrary.org/obo/BFO_0000031 generically dependent continuant http://purl.obolibrary.org/obo/BFO_0000040 material entity http://www.geneontology.org/formats/oboInOwl#ObsoleteClass Obsolete Class http://purl.obolibrary.org/obo/OBI_1110060 process is result of http://purl.obolibrary.org/obo/RO_0002087 immediately preceded by is a relationship between a process and a preceding occurrent that directly caused the later one to occur http://purl.obolibrary.org/obo/RO_0002087 immediately preceded by http://purl.obolibrary.org/obo/BFO_0000062 preceded by starts_at_end_of http://purl.obolibrary.org/obo/RO_0000053 bearer of is bearer of a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0000056 participates in participates_in a relation between a continuant and a process, in which the continuant is somehow involved in the process http://purl.obolibrary.org/obo/RO_0000057 has participant has_participant a relation between a process and a continuant, in which the continuant is somehow involved in the process http://purl.obolibrary.org/obo/BFO_0000051 has part has_part a core relation that holds between a whole and its part http://purl.obolibrary.org/obo/IAO_0000136 is about is_about is a (currently) primitive relation that relates an information artifact to an entity. http://purl.obolibrary.org/obo/OBI_0000293 has_specified_input A relation between a planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of. http://purl.obolibrary.org/obo/OBI_0000312 is_specified_output_of A relation between a planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of. http://purl.obolibrary.org/obo/RO_0002351 has member has member is a mereological relation between a collection and an item. http://purl.obolibrary.org/obo/BFO_0000117 has occurrent part b has_occurrent_part c = Def. c occurrent_part_of b. (axiom label in BFO2 Reference: [007-001]) http://purl.obolibrary.org/obo/BFO_0000062 preceded by preceded_by http://semanticscience.org/resource/SIO_000095 is member of