Term IRI	Term label	Parent term IRI	Parent term label	Alternative term	Definition
http://purl.obolibrary.org/obo/NCIT_R153	Allele_Has_Abnormality	http://purl.obolibrary.org/obo/NCIT_R132	Gene_Has_Abnormality		A specializing role which may be used to override Gene_Has_Abnormality that has been asserted for the gene class. This role is used to establish a link between a specific allele and genetic or molecular abnormalities that have been observed in human cells and tissues associated with cancer or another disease of interest. The domain and range for this role are 'Gene' and 'Molecular Abnormality', respectively.
http://purl.obolibrary.org/obo/NCIT_R156	Allele_Absent_From_Wild-type_Chromosomal_Location	http://purl.obolibrary.org/obo/NCIT_R40	Gene_In_Chromosomal_Location		A role used for an allele whose location has changed from the wild-type gene chromosomal location. This role is used to negate an inherited role relationship that is asserted between the parent gene class and a chromosomal location when an allele has moved (e.g., translocation, inversion, etc.). The domain and range for this role are 'Gene' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R158	Allele_Plays_Altered_Role_In_Process	http://purl.obolibrary.org/obo/NCIT_R37	Gene_Plays_Role_In_Process		A specializing role which may be used for an allele whose encoded product functions differently (qualitatively or quantitatively) from the function asserted on its parent. It specializes the function of the wild type gene/gene product. The domain and range for this role are 'Gene' and 'Biological Process', respectively.
http://purl.obolibrary.org/obo/NCIT_R165	Procedure_Has_Imaged_Anatomy	http://purl.obolibrary.org/obo/NCIT_R163	Procedure_Has_Target_Anatomy		A role used to assert a relationship between an imaging procedure and its target anatomy, specifically that a particular procedure always involves imaging the specified anatomy. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R166	Procedure_May_Have_Excised_Anatomy	http://purl.obolibrary.org/obo/NCIT_R163	Procedure_Has_Target_Anatomy		A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure sometimes results in excision of some or all of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs. It should be used when a more specific role cannot be asserted. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R167	Procedure_Has_Excised_Anatomy	http://purl.obolibrary.org/obo/NCIT_R166	Procedure_May_Have_Excised_Anatomy		A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure always involves excision of some or all of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs. It should be used when a more specific role cannot be asserted. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R168	Procedure_May_Have_Partially_Excised_Anatomy	http://purl.obolibrary.org/obo/NCIT_R167	Procedure_Has_Excised_Anatomy		A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure sometimes results in partial excision of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where partial excision is explicit or can be inferred (e.g. biopsy). The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R169	Procedure_Has_Partially_Excised_Anatomy	http://purl.obolibrary.org/obo/NCIT_R168	Procedure_May_Have_Partially_Excised_Anatomy		A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure always involves partial excision of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where partial excision is explicit or can be inferred (e.g. biopsy). The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R170	Procedure_May_Have_Completely_Excised_Anatomy	http://purl.obolibrary.org/obo/NCIT_R167	Procedure_Has_Excised_Anatomy		A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure sometimes results in complete excision of the target anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where complete excision is explicit or can be inferred. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R171	Procedure_Has_Completely_Excised_Anatomy	http://purl.obolibrary.org/obo/NCIT_R170	Procedure_May_Have_Completely_Excised_Anatomy		A role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure always is intended for the complete excision of the target anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where complete excision is explicit or can be inferred. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R155	Allele_In_Chromosomal_Location	http://purl.obolibrary.org/obo/NCIT_R40	Gene_In_Chromosomal_Location		A role used for an allele whose location has changed from the wild-type gene chromosomal location. This role is used to assert a new location that differs from the wild-type gene chromosomal location. The domain and range for this role are 'Gene' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R100	Disease_Has_Associated_Anatomic_Site				A role used to relate a disease to the general site, structure or system where the specific pathological process is located. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R101	Disease_Has_Primary_Anatomic_Site				A role used to relate a disease to the anatomical site where the originating pathological process is located. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R102	Disease_Has_Metastatic_Anatomic_Site				A role used to relate a disease to the site of a metastatic lesion associated with the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R103	Disease_Has_Normal_Tissue_Origin				A role used to relate a disease to the type of normal tissue in which the disease process began. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R104	Disease_Has_Normal_Cell_Origin				A role used to relate a disease to the type of normal cell in which the disease process begins. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R105	Disease_Has_Abnormal_Cell				A role used to relate a disease to the type of neoplastic cell present in and characteristic of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Abnormal Cell', respectively.
http://purl.obolibrary.org/obo/NCIT_R111	Disease_May_Have_Normal_Tissue_Origin				A role used to represent that a normal tissue type will only be the type of origin in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R112	Disease_May_Have_Normal_Cell_Origin				A role used to represent that a normal cell type will only be the type of origin in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R113	Disease_May_Have_Abnormal_Cell				A role used to represent that particular neoplastic cell types will only be present in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Abnormal Cell', respectively.
http://purl.obolibrary.org/obo/NCIT_R115	Disease_May_Have_Finding				A role used to represent that a clinical observation, sign or symptom will only be observed in some cases of the disease. Both the domain and range for this role are 'Disease, Disorder or Finding'.
http://purl.obolibrary.org/obo/NCIT_R116	Disease_May_Have_Associated_Disease				A role used to represent that another disease or disorder will only be observed in some cases of the specified disease. Both the domain and the range for this role are 'Disease, Disorder or Finding'.
http://purl.obolibrary.org/obo/NCIT_R126	Disease_Has_Associated_Disease				A role used to relate a disease to another disease or disorder, but without specification or limitation of the relationship (causality or timing for example). Both the domain and the range for this role are 'Disease, Disorder or Finding'.
http://purl.obolibrary.org/obo/NCIT_R132	Gene_Has_Abnormality				A role used to establish a link between a gene and the genetic or molecular abnormalities that have been observed in human cells and tissues associated with cancers (e.g., over- or under-expressed, amplified, translocated). The domain and range for this role are 'Gene' and 'Molecular Abnormality', respectively.
http://purl.obolibrary.org/obo/NCIT_R133	Gene_Product_Has_Abnormality				A role used to establish a link between a gene product and the molecular abnormalities that are observed in human cells and tissues in association with diseases such as cancers (e.g., over or under-expression of gene product). The domain and range for this role are 'Gene Product' and 'Molecular Abnormality', respectively.
http://purl.obolibrary.org/obo/NCIT_R135	Disease_Excludes_Primary_Anatomic_Site				A specializing role which may be used to override Disease_Has_Associated_Anatomic_Site. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R136	Disease_Excludes_Metastatic_Anatomic_Site				A specializing role which may be used to override Disease_Has_ Metastatic_Anatomic_Site. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R137	Disease_Excludes_Normal_Tissue_Origin				A specializing role which may be used to override Disease_Has_Normal_Tissue_Origin. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R138	Disease_Excludes_Normal_Cell_Origin				A specializing role which may be used to override Disease_Has_Normal_Cell_Origin. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R139	Disease_Excludes_Abnormal_Cell				A specializing role which may be used to override Disease_Has_Abnormal_Cell. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Abnormal Cell', respectively.
http://purl.obolibrary.org/obo/NCIT_R145	Gene_Has_Physical_Location				A role used to link a gene with its physical extent on a chromosome, denoted by the chromosome number and start and end base positions (with numbering beginning at the telomere of the short p arm). The domain and range for this role are 'Gene' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R150	Chemical_Or_Drug_Affects_Abnormal_Cell				A role used to establish the relationship between a therapeutic agent and an abnormal cell type associated with a disease condition. By pointing to abnormal cells, the therapeutic target of a drug can be more clearly conveyed. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Abnormal Cell', respectively.
http://purl.obolibrary.org/obo/NCIT_R159	Allele_Has_Activity				A role used to assert the observed level of activity associated with an allele in a given biological process, compared to the wild-type gene. The domain and range for this role are 'Gene' and 'Property or Attribute', respectively.
http://purl.obolibrary.org/obo/NCIT_R160	Allele_Plays_Role_In_Metabolism_Of_Chemical_Or_Drug				A role used to assert a relationship between a specific allele (product; enzyme) and drug-metabolizing efficacy. The domain and range for this role are 'Gene' and 'Drug, Food, Chemical or Biomedical Material', respectively.
http://purl.obolibrary.org/obo/NCIT_R163	Procedure_Has_Target_Anatomy				A role used to assert a relationship between a procedure and its target anatomy, specifically that a particular procedure always has an association with the target anatomy. This role should be used when a more specific role cannot be asserted, including procedures targeting blood and other fluids. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R172	Regimen_Has_Accepted_Use_For_Disease				A role used to link established therapeutic regimens to their corresponding cancers or other diseases. Only established regimens published in NCI's Physician Data Query (PDQ), National Comprehensive Cancer Network (NCCN) Guidelines (http://www.nccn.org), or a limited number of other authoritative sources such as the Physician's Cancer Chemotherapy Manual are included. The domain and range for this role are 'Chemotherapy Regimen or Agent Combination' and 'Disease, Disorder or Finding', respectively.
http://purl.obolibrary.org/obo/NCIT_R174	Disease_Mapped_To_Chromosome				A role used to assert a relationship between a disease, disorder or finding and a chromosome. This restriction should be used when a disease or disorder maps to a chromosome.  It is not meant to be used when a specific cytogenetic abnormality is known (e.g. translocation, inversion). The domain and range for this role are 'Disease, Disorder or Finding' and 'Chromosome', respectively. The range for this role excludes chromosomal bands and physical locations.
http://purl.obolibrary.org/obo/NCIT_R176	Disease_Mapped_To_Gene				A role used to assert a direct relationship between a disease, disorder or finding and a gene. This restriction can be used when a polymorphism or an abnormality in a gene is either a clinical marker for, a causative event for, or predisposes a subject to a disease. The domain and range for this role are 'Disease, Disorder or Finding' and 'Gene', respectively.
http://purl.obolibrary.org/obo/NCIT_R180	Procedure_Has_Target_Disease				A role used to assert that a procedure or technical method detects, diagnoses, or treats a specified disease state. The domain and range for this role are 'Activity' and 'Disease, Disorder or Finding', respectively.
http://purl.obolibrary.org/obo/NCIT_R181	Procedure_Uses_Manufactured_Object				A role used to assert that a procedure or technical method requires use of specific artifacts or pieces of equipment. The domain and range for this role are 'Activity' and 'Manufactured Object', respectively.
http://purl.obolibrary.org/obo/NCIT_R23	EO_Disease_Has_Associated_Cell_Type				A role used to specify the associated cell type of a disease in an experimental organism. The domain and range for this role are 'Experimental Organism Diagnosis' and 'Experimental Organism Anatomical Concept', respectively.
http://purl.obolibrary.org/obo/NCIT_R24	EO_Disease_Maps_To_Human_Disease				A role is used to establish a relationship between a disease in an experimental organism and a corresponding human disease. The domain and the range for this role are 'Experimental Organism Diagnosis' and 'Disease, Disorder or Finding', respectively.
http://purl.obolibrary.org/obo/NCIT_R25	EO_Disease_Has_Associated_EO_Anatomy				A role used to specify the general site, structure or system where a pathological process is located in an experimental organism. The domain and range for this role are 'Experimental Organism Diagnosis' and 'Experimental Organism Anatomical Concept', respectively.
http://purl.obolibrary.org/obo/NCIT_R26	EO_Disease_Has_Property_Or_Attribute				A role used to specify the clinical behavior, or other characteristic, of a disease in an experimental organism. The domain and range for this role are 'Experimental Organism Diagnosis' and 'Property or Attribute', respectively.
http://purl.obolibrary.org/obo/NCIT_R28	Biological_Process_Has_Initiator_Process				A role used to assert that the initiation of the stated biological process is dependent on the progression or completion of another process. The role implies a direct physical and functional interaction of an element from the preceding biological process with a target molecule or complex involved in the initial stages of the stated process. Both the domain and the range for this role are 'Biological Process'.
http://purl.obolibrary.org/obo/NCIT_R29	Biological_Process_Has_Result_Chemical_Or_Drug				A role used to assert that the endpoint of a biological process is the creation of a drug, chemical or biomedical material. The domain and range for this role are 'Biological Process' and 'Drug, Food, Chemical or Biomedical Material', respectively.
http://purl.obolibrary.org/obo/NCIT_R30	Biological_Process_Has_Associated_Location				A role used to indicate the organ, organ system, cellular or subcellular location where a process occurs in a living system. The domain and range for this role are 'Biological Process' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R31	Biological_Process_Has_Result_Anatomy				A role used to assert that some biological event results in the formation of a subcellular complex, structure, cell, tissue or organ. This role is used to establish this relationship between the biological process and the anatomical factor formed. The domain and range for this role are 'Biological Process' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R32	Biological_Process_Has_Initiator_Chemical_Or_Drug				A role used to assert the relationship between a biological process and a drug or chemical that stimulates the process. The role implies the direct physical interaction of a chemical or drug with a target molecule or complex that results in the initiation of the process. The domain and range for this role are 'Biological Process' and 'Drug, Food, Chemical or Biomedical Material', respectively.
http://purl.obolibrary.org/obo/NCIT_R34	Biological_Process_Has_Result_Biological_Process				A role used to assert that the end result of a biological process initiates a subsequent biological process. Both the domain and the range for this role is 'Biological Process'.
http://purl.obolibrary.org/obo/NCIT_R35	Biological_Process_Is_Part_Of_Process				A role used to assert that a biological process operates as a component of another biological process. Both the domain and the range for this role is 'Biological Process'.
http://purl.obolibrary.org/obo/NCIT_R36	Gene_Is_Biomarker_Type				A role used to designate the type of biomarker a gene is; it points to a small tree of biomarker types (e.g., Disease Marker, Metabolic Marker, Prognostic Marker). The domain and range for this role are 'Gene' and 'Diagnostic or Prognostic Factor', respectively.
http://purl.obolibrary.org/obo/NCIT_R38	Gene_Associated_With_Disease				A role used to indicate that molecular abnormalities in a gene may be associated with the manifestation of a disease. The role is used to assert a link between a gene and a disease when the association is considered to have clinical relevance. The domain and range for this role are 'Gene' and 'Disease, Disorder or Finding', respectively.
http://purl.obolibrary.org/obo/NCIT_R39	Gene_Is_Biomarker_Of				A role used to assert that expression or alteration of a gene is correlated with a particular disease or disease state or is predictive of the disease or disease state. The domain and range for this role are 'Gene' and Findings_and_Disorder_Kind, respectively.
http://purl.obolibrary.org/obo/NCIT_R42	Gene_Product_Is_Biomarker_Type				A role used to designate the type of biomarker a gene product is; it points to a small tree of biomarker types (e.g., Disease Marker, Metabolic Marker, Prognostic Marker). The domain and range for this role are 'Gene Product' and 'Diagnostic or Prognostic Factor', respectively.
http://purl.obolibrary.org/obo/NCIT_R47	Gene_Product_Is_Biomarker_Of				A role used to indicate that presence of a gene product may contribute to clinical diagnosis, treatment selection, or prediction of clinical outcome. The domain and range for this role are 'Gene Product' and 'Disease, Disorder or Finding', respectively.
http://purl.obolibrary.org/obo/NCIT_R48	Gene_Product_Malfunction_Associated_With_Disease				A role used to indicate that molecular abnormalities in a gene product may be associated with the manifestation of a disease. The role is used to assert a link between a gene product and a disease when the association is considered to have clinical relevance. The domain and range for this role are 'Gene Product' and 'Disease, Disorder or Finding', respectively.
http://purl.obolibrary.org/obo/NCIT_R81	Anatomic_Structure_Has_Location				A role used to indicate the physical location of an anatomic structure in the body. Both the domain and range for this role are 'Anatomic Structure, System, or Substance'.
http://purl.obolibrary.org/obo/NCIT_R88	Disease_Is_Stage				A role used to specify the disease stage of a disease, the extent to which a cancer has spread from the original site to other parts of the body. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Property or_Attribute', respectively.
http://purl.obolibrary.org/obo/NCIT_R89	Disease_May_Have_Molecular_Abnormality				A role used to represent that a molecular abnormality will only be present in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
http://purl.obolibrary.org/obo/NCIT_R175	Gene_Involved_In_Pathogenesis_Of_Disease				A role used to assert a direct relationship between a gene and a disease. This restriction should only be used when an abnormality in a gene a causative event for a disease. The domain and range for this role are 'Gene' and 'Disease or Disorder', respectively.
http://purl.obolibrary.org/obo/NCIT_R178	Gene_Mutant_Encodes_Gene_Product_Sequence_Variation				A role used to indicate that a specific molecular variation or mutation in a gene encodes a gene product sequence variant. The domain and range for this role are 'Gene Mutant' and 'Gene Product Sequence Variation', respectively.
http://purl.obolibrary.org/obo/NCIT_R179	Gene_Product_Sequence_Variation_Encoded_By_Gene_Mutant				A role used to indicate that a gene product sequence variation is encoded by a specific gene mutant. The domain and range for this role are 'Gene Product Sequence Variation' and 'Gene Mutant', respectively.
http://purl.obolibrary.org/obo/NCIT_R182	Gene_Product_Variant_Of_Gene_Product				A role used to indicate that a gene product sequence variation is related to a wild-type gene product. The domain and range for this role are 'Gene Product Sequence Variation' and 'Gene Product', respectively.
http://purl.obolibrary.org/obo/NCIT_R41	Gene_Found_In_Organism				A role used to specify the organism of origin for a gene. It may be used to differentiate genes with the same name and functions that originate from different organisms. The domain and range for this role are 'Gene' and 'Organism', respectively.
http://purl.obolibrary.org/obo/NCIT_R45	Gene_Product_Has_Organism_Source				A role used to differentiate homologous proteins from different organisms. The domain and range for this role are 'Gene Product' and 'Organism', respectively.
http://purl.obolibrary.org/obo/NCIT_R51	Gene_Product_Is_Physical_Part_Of				A role used to indicate that a gene product normally functions as a component of a "functional complex". Both the domain and range for this role are 'Gene Product'.
http://purl.obolibrary.org/obo/NCIT_R82	Anatomic_Structure_Is_Physical_Part_Of				A role used to indicate that an anatomic structure has a physical association with a broader system or organ. Both the domain and range for this role are 'Anatomic Structure, System, or Substance'.
http://purl.obolibrary.org/obo/NCIT_R106	Disease_Has_Molecular_Abnormality				A role used to relate a disease to a molecular abnormality that is present in the specified disease state. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
http://purl.obolibrary.org/obo/NCIT_R107	Disease_Has_Cytogenetic_Abnormality				A role used to relate a disease to the type of chromosomal abnormality present in the specified disease state. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
http://purl.obolibrary.org/obo/NCIT_R108	Disease_Has_Finding				A role used to relate a disease to a clinical observation, sign or symptom present in and characteristic of the disease. Both the domain and range for this role are 'Disease, Disorder or Finding'.
http://purl.obolibrary.org/obo/NCIT_R110	Disease_Is_Grade				A role used to relate a disease to a grading system which classifies the cancer cells in terms of how abnormal they appear when examined under a microscope. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Property or_Attribute', respectively.
http://purl.obolibrary.org/obo/NCIT_R114	Disease_May_Have_Cytogenetic_Abnormality				A role used to represent that a particular cytogenetic abnormality will only be present in some cases of the disease. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
http://purl.obolibrary.org/obo/NCIT_R122	Chemical_Or_Drug_Is_Metabolized_By_Enzyme				A role used to specify that an enzyme is directly responsible for metabolizing a chemical or drug into an active form, inactive form, or both. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Gene Product', respectively.
http://purl.obolibrary.org/obo/NCIT_R123	Chemotherapy_Regimen_Has_Component				A role used to specify the component agents which are used in a particular chemotherapy regimen or agent combination. The domain and the range for this role are 'Chemotherapy Regimen or Agent Combination' and 'Drug, Food, Chemical or Biomedical Material', respectively.
http://purl.obolibrary.org/obo/NCIT_R124	Chemical_Or_Drug_Has_Mechanism_Of_Action				A role used to imply the interaction or binding of an active ingredient of a drug/chemical agent at the molecular level with its target. When possible, the role value should reflect the direct alteration of function of a target molecule or complex. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Biological Process', respectively.
http://purl.obolibrary.org/obo/NCIT_R125	Chemical_Or_Drug_Has_Physiologic_Effect				A role used to describe the primary detectable alterations of subcellular, cellular, tissue, or organ functions that directly result from alteration of function of a target biological molecule or complex caused by interaction of a therapeutic agent with a target molecule or complex. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Biological Process', respectively.
http://purl.obolibrary.org/obo/NCIT_R130	Gene_Is_Element_In_Pathway				A role used to assert a relationship between a gene and a biochemical pathway in which its encoded gene product(s) participate. This relationship is used only when gene has been implicated in a pathway by the curated source (Biocarta, KEGG or PID). The domain and range for this role are 'Gene' and 'Biochemical Pathway', respectively.
http://purl.obolibrary.org/obo/NCIT_R131	Gene_Product_Is_Element_In_Pathway				A role used to assert a relationship between a gene product and a biochemical pathway in which it participates. This relationship is used only when a gene product has been implicated in a pathway by the curated source (Biocarta, KEGG or PID). The domain and range for this role are 'Gene Product' and 'Biochemical Pathway', respectively.
http://purl.obolibrary.org/obo/NCIT_R140	Disease_Excludes_Molecular_Abnormality				A specializing role which may be used to override Disease_Has_ Molecular_Abnormality. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
http://purl.obolibrary.org/obo/NCIT_R141	Disease_Excludes_Cytogenetic_Abnormality				A specializing role which may be used to override Disease_Has_Cytogenetic_Abnormality. The domain and the range for this role are 'Disease, Disorder or Finding' and 'Molecular Abnormality', respectively.
http://purl.obolibrary.org/obo/NCIT_R142	Disease_Excludes_Finding				A specializing role which may be used to override Disease_Has_Finding. Both the domain and range for this role are 'Disease, Disorder or Finding'.
http://purl.obolibrary.org/obo/NCIT_R146	Chemical_Or_Drug_Affects_Gene_Product				A role used to assert that a gene product is the target of a therapeutic agent. The role implies a direct interaction between the product and the therapeutic agent but it does not specify the type of association (e.g., involvement, interference, inhibition or cleavage). The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Gene Product', respectively.
http://purl.obolibrary.org/obo/NCIT_R173	Cytogenetic_Abnormality_Involves_Chromosome				A role used to assert a direct relationship between a cytogenetic abnormality and a chromosome. The domain and range for this role are 'Cytogenetic Abnormality' and 'Chromosome', respectively. The range for this role excludes chromosomal bands and physical locations.
http://purl.obolibrary.org/obo/NCIT_R177	Molecular_Abnormality_Involves_Gene				A role used to assert a direct relationship between a molecular abnormality and a gene. The domain and range for this role are 'Molecular Abnormality' and 'Gene', respectively.
http://purl.obolibrary.org/obo/NCIT_R27	Conceptual_Part_Of				A role used to indicate that a conceptual entity is a sub-entity of another conceptual entity. Both the domain and the range for this role are 'Conceptual Entity'.
http://purl.obolibrary.org/obo/NCIT_R37	Gene_Plays_Role_In_Process				A role used to assert a relationship between a gene and a biological process in which its encoded gene product(s) participate. The domain and range for this role are 'Gene' and 'Biological Process', respectively.
http://purl.obolibrary.org/obo/NCIT_R40	Gene_In_Chromosomal_Location				A role used to assert a relationship between a gene and its general location, specified by chromosomal band position (infrequently by chromosome number or chromosome arm). The domain and range for this role are 'Gene' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R44	Gene_Product_Has_Chemical_Classification				A role used to specify the physical structure type of a protein molecule (e.g. metalloprotein, transmembrane protein). Both the domain and range for this role are 'Gene Product'.
http://purl.obolibrary.org/obo/NCIT_R46	Gene_Product_Has_Associated_Anatomy				A role used to specify physical structures or typical subcellular locations of a gene product. The domain and range for this role are 'Gene Product' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R49	Gene_Product_Expressed_In_Tissue				A role used to specify that a normal tissue is the normal location for the expression of a gene product. The domain and range for this role are 'Gene Product' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R50	Gene_Product_Has_Structural_Domain_Or_Motif				A role used specify information about protein domains or motifs present in a protein that can give insight into protein function. The domain and range for this role are 'Gene Product' and 'Anatomic Structure, System, or Substance', respectively.
http://purl.obolibrary.org/obo/NCIT_R52	Gene_Product_Has_Biochemical_Function				A role used to denote the biochemical activity of a gene product. Both the domain and range for this role are 'Gene Product'.
http://purl.obolibrary.org/obo/NCIT_R53	Gene_Product_Plays_Role_In_Biological_Process				A role used to assert that a gene product participates in a specific biological process. The domain and range for this role are 'Gene Product' and 'Biological Process', respectively.
http://purl.obolibrary.org/obo/NCIT_R54	Gene_Product_Encoded_By_Gene				A role used to assert a relationship between a gene product and the gene that encodes it. The domain and range for this role are 'Gene Product' and 'Gene', respectively.
http://purl.obolibrary.org/obo/NCIT_R66	Chemical_Or_Drug_Plays_Role_In_Biological_Process				A role used to assert that an active ingredient of a drug or chemical agent influences a biological process. The role implies a direct association with a target biological molecule or complex involved in the process. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Biological Process', respectively.
http://purl.obolibrary.org/obo/NCIT_R72	Chemical_Or_Drug_Affects_Cell_Type_Or_Tissue				A role used to represent the intended target cells for a chemical or drug. This does not include unintended target cells or tissues that are associated with side effects or toxicity of the chemical or drug. The domain and range for this role are 'Drug, Food, Chemical or Biomedical Material' and 'Anatomic Structure, System, or Substance', respectively.