Term IRI Term label Parent term IRI Parent term label Alternative term Definition http://purl.obolibrary.org/obo/CHEBI_25000 lactone http://purl.obolibrary.org/obo/CHEBI_35701 ester Any cyclic carboxylic ester containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring. http://purl.obolibrary.org/obo/CHEBI_33261 organosulfur compound http://purl.obolibrary.org/obo/CHEBI_26835 sulfur molecular entity An organosulfur compound is a compound containing at least one carbon-sulfur bond. http://purl.obolibrary.org/obo/CHEBI_33822 organic hydroxy compound http://purl.obolibrary.org/obo/CHEBI_50860 organic molecular entity An organic compound having at least one hydroxy group attached to a carbon atom. http://purl.obolibrary.org/obo/CHEBI_35341 steroid http://purl.obolibrary.org/obo/CHEBI_51958 organic polycyclic compound Any of naturally occurring compounds and synthetic analogues, based on the cyclopenta[a]phenanthrene carbon skeleton, partially or completely hydrogenated; there are usually methyl groups at C-10 and C-13, and often an alkyl group at C-17. By extension, one or more bond scissions, ring expansions and/or ring contractions of the skeleton may have occurred. Natural steroids are derived biogenetically from squalene, so may be considered as triterpenoids. http://purl.obolibrary.org/obo/CHEBI_38101 organonitrogen heterocyclic compound http://purl.obolibrary.org/obo/CHEBI_35352 organonitrogen compound Any organonitrogen compound containing a cyclic component with nitrogen and at least one other element as ring member atoms. http://purl.obolibrary.org/obo/CHEBI_5686 heterocyclic compound http://purl.obolibrary.org/obo/CHEBI_33595 cyclic compound A cyclic compound having as ring members atoms of at least two different elements. http://purl.obolibrary.org/obo/CHEBI_35505 hydrate http://purl.obolibrary.org/obo/CHEBI_37577 heteroatomic molecular entity An addition compound that contains water in weak chemical combination with another compound. http://purl.obolibrary.org/obo/CHEBI_16826 acyl monophosphate http://purl.obolibrary.org/obo/CHEBI_25703 organic phosphate An organic phosphate ester or anhydride formed by condensation of phosphoric acid with a carboxylic acid. http://purl.obolibrary.org/obo/CHEBI_18059 lipid http://purl.obolibrary.org/obo/CHEBI_50860 organic molecular entity 'Lipids' is a loosely defined term for substances of biological origin that are soluble in nonpolar solvents. They consist of saponifiable lipids, such as glycerides (fats and oils) and phospholipids, as well as nonsaponifiable lipids, principally steroids. http://purl.obolibrary.org/obo/CHEBI_24838 inorganic phosphate http://purl.obolibrary.org/obo/CHEBI_26020 phosphate Any phosphate that contains no carbon atom. http://purl.obolibrary.org/obo/CHEBI_25367 molecule http://purl.obolibrary.org/obo/CHEBI_36357 polyatomic entity Any polyatomic entity that is an electrically neutral entity consisting of more than one atom. http://purl.obolibrary.org/obo/CHEBI_31624 fluorescein http://purl.obolibrary.org/obo/CHEBI_38164 organic heteropentacyclic compound A xanthene dye that is highly fluorescent, detectable even when present in minute quantities. Used forensically to detect traces of blood, in analytical chemistry as an indicator in silver nitrate titrations and in microscopy. http://purl.obolibrary.org/obo/CHEBI_33247 organic group http://purl.obolibrary.org/obo/CHEBI_24431 chemical entity Any substituent group or skeleton containing carbon. http://purl.obolibrary.org/obo/CHEBI_33708 amino-acid residue http://purl.obolibrary.org/obo/CHEBI_33247 organic group When two or more amino acids combine to form a peptide, the elements of water are removed, and what remains of each amino acid is called an amino-acid residue. http://purl.obolibrary.org/obo/CHEBI_36836 3beta-hydroxy steroid http://purl.obolibrary.org/obo/CHEBI_30879 alcohol A 3-hydroxy steroid in which the 3-hydroxy substituent is in the beta-position. http://purl.obolibrary.org/obo/CHEBI_36976 nucleotide http://purl.obolibrary.org/obo/CHEBI_25608 nucleoside phosphate A nucleotide is a nucleoside phosphate resulting from the condensation of the 3 or 5 hydroxy group of a nucleoside with phosphoric acid. http://purl.obolibrary.org/obo/CHEBI_51751 enamide http://purl.obolibrary.org/obo/CHEBI_50860 organic molecular entity An alpha,beta-unsaturated carboxylic acid amide of general formula R(1)R(2)C=CR(3)-C(=O)NR(4)R(5) in which the amide C=O function is conjugated to a C=C double bond at the alpha,beta position. http://purl.obolibrary.org/obo/CHEBI_61120 nucleobase-containing molecular entity http://purl.obolibrary.org/obo/CHEBI_33833 heteroarene Any compound that has a nucleobase as a part. http://purl.obolibrary.org/obo/CHEBI_65212 polysaccharide derivative http://purl.obolibrary.org/obo/CHEBI_33694 biomacromolecule A carbohydrate derivative that is any derivative of a polysaccharide. http://purl.obolibrary.org/obo/CHEBI_76551 N-nitrosoureas http://purl.obolibrary.org/obo/CHEBI_47857 ureas A nitroso compound that is any urea in which one of the nitrogens is substituted by a nitroso group http://purl.obolibrary.org/obo/CHEBI_23075 glycotetraosylceramide http://purl.obolibrary.org/obo/CHEBI_36520 oligoglycosylceramide An oligoglycosylceramide consisting of a glycotetraosyl moiety attached to the ceramide oxygen with an unspecified N-acyl substituent attached to the ceramide nitrogen. http://purl.obolibrary.org/obo/CHEBI_23367 molecular entity http://purl.obolibrary.org/obo/BFO_0000040 material entity Any constitutionally or isotopically distinct atom, molecule, ion, ion pair, radical, radical ion, complex, conformer etc., identifiable as a separately distinguishable entity. http://purl.obolibrary.org/obo/CHEBI_23995 N-ethyl-N-nitrosourea http://purl.obolibrary.org/obo/CHEBI_76551 N-nitrosoureas A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups. http://purl.obolibrary.org/obo/CHEBI_24402 glycosphingolipid http://purl.obolibrary.org/obo/CHEBI_26739 sphingolipid A glycosphingolipid is a glycolipid that is a carbohydrate-containing derivative of a sphingoid or ceramide. It is understood that the carbohydrate residue is attached by a glycosidic linkage to O-1 of the sphingoid. http://purl.obolibrary.org/obo/CHEBI_24431 chemical entity http://purl.obolibrary.org/obo/BFO_0000040 material entity A chemical entity is a physical entity of interest in chemistry including molecular entities, parts thereof, and chemical substances. http://purl.obolibrary.org/obo/CHEBI_24532 organic heterocyclic compound http://purl.obolibrary.org/obo/CHEBI_33832 organic cyclic compound A cyclic compound having as ring members atoms of carbon and at least of one other element. http://purl.obolibrary.org/obo/CHEBI_24636 proton http://purl.obolibrary.org/obo/CHEBI_15378 hydron Nuclear particle of charge number +1, spin 1/2 and rest mass of 1.007276470(12) u. http://purl.obolibrary.org/obo/CHEBI_24651 hydroxides http://purl.obolibrary.org/obo/CHEBI_37577 heteroatomic molecular entity Hydroxides are chemical compounds containing a hydroxy group or salts containing hydroxide (OH(-)). http://purl.obolibrary.org/obo/CHEBI_24835 inorganic molecular entity http://purl.obolibrary.org/obo/CHEBI_23367 molecular entity A molecular entity that contains no carbon. http://purl.obolibrary.org/obo/CHEBI_24866 salt http://purl.obolibrary.org/obo/CHEBI_37577 heteroatomic molecular entity A salt is an assembly of cations and anions. http://purl.obolibrary.org/obo/CHEBI_24870 ion http://purl.obolibrary.org/obo/CHEBI_23367 molecular entity A molecular entity having a net electric charge. http://purl.obolibrary.org/obo/CHEBI_25710 organophosphorus compound http://purl.obolibrary.org/obo/CHEBI_33285 heteroorganic entity An organophosphorus compound is formally a compound containing at least one carbon-phosphorus bond, but the term is often extended to include esters and thioesters. http://purl.obolibrary.org/obo/CHEBI_25741 oxide http://purl.obolibrary.org/obo/CHEBI_37577 heteroatomic molecular entity An oxide is a chemical compound of oxygen with other chemical elements. http://purl.obolibrary.org/obo/CHEBI_26020 phosphate http://purl.obolibrary.org/obo/CHEBI_26079 phosphoric acid derivative Salts and esters of phosphoric and oligophosphoric acids and their chalcogen analogues. In inorganic chemistry, the term is also used to describe anionic coordination entities with phosphorus as central atom. http://purl.obolibrary.org/obo/CHEBI_26395 purine nucleotide http://purl.obolibrary.org/obo/CHEBI_26401 purines Any nucleotide that has a purine nucleobase. http://purl.obolibrary.org/obo/CHEBI_26400 purine ribonucleotide http://purl.obolibrary.org/obo/CHEBI_26395 purine nucleotide Any ribonucleotide that has a purine nucleobase. http://purl.obolibrary.org/obo/CHEBI_26710 sodium chloride http://purl.obolibrary.org/obo/CHEBI_36093 inorganic chloride An inorganic chloride salt having sodium(1+) as the counterion. http://purl.obolibrary.org/obo/CHEBI_26714 sodium salt http://purl.obolibrary.org/obo/CHEBI_35479 alkali metal salt Any alkali metal salt having sodium(1+) as the cation. http://purl.obolibrary.org/obo/CHEBI_28073 chromium atom http://purl.obolibrary.org/obo/CHEBI_33350 chromium group element atom A chromium group element atom that has atomic number 24. http://purl.obolibrary.org/obo/CHEBI_28619 acrylamide http://purl.obolibrary.org/obo/CHEBI_37622 carboxamide A member of the class of acrylamides that results from the formal condensation of acrylic acid with ammonia. http://purl.obolibrary.org/obo/CHEBI_33238 monoatomic entity http://purl.obolibrary.org/obo/CHEBI_33259 elemental molecular entity A monoatomic entity is a molecular entity consisting of a single atom. http://purl.obolibrary.org/obo/CHEBI_33250 atom http://purl.obolibrary.org/obo/CHEBI_24431 chemical entity A chemical entity constituting the smallest component of an element having the chemical properties of the element. http://purl.obolibrary.org/obo/CHEBI_33253 nucleon http://purl.obolibrary.org/obo/CHEBI_36347 nuclear particle Heavy nuclear particle: proton or neutron. http://purl.obolibrary.org/obo/CHEBI_33259 elemental molecular entity http://purl.obolibrary.org/obo/CHEBI_23367 molecular entity A molecular entity all atoms of which have the same atomic number. http://purl.obolibrary.org/obo/CHEBI_33285 heteroorganic entity http://purl.obolibrary.org/obo/CHEBI_50860 organic molecular entity A heteroorganic entity is an organic molecular entity in which carbon atoms or organic groups are bonded directly to one or more heteroatoms. http://purl.obolibrary.org/obo/CHEBI_33296 alkali metal molecular entity http://purl.obolibrary.org/obo/CHEBI_33674 s-block molecular entity A molecular entity containing one or more atoms of an alkali metal. http://purl.obolibrary.org/obo/CHEBI_33302 pnictogen molecular entity http://purl.obolibrary.org/obo/CHEBI_33675 p-block molecular entity A p-block molecular entity containing any pnictogen. http://purl.obolibrary.org/obo/CHEBI_33304 chalcogen molecular entity http://purl.obolibrary.org/obo/CHEBI_33675 p-block molecular entity Any p-block molecular entity containing a chalcogen. http://purl.obolibrary.org/obo/CHEBI_33521 metal atom http://purl.obolibrary.org/obo/CHEBI_33250 atom An atom of an element that exhibits typical metallic properties, being typically shiny, with high electrical and thermal conductivity. http://purl.obolibrary.org/obo/CHEBI_33675 p-block molecular entity http://purl.obolibrary.org/obo/CHEBI_33579 main group molecular entity A main group molecular entity that contains one or more atoms of a p-block element. http://purl.obolibrary.org/obo/CHEBI_33832 organic cyclic compound http://purl.obolibrary.org/obo/CHEBI_33595 cyclic compound Any organic molecule that consists of atoms connected in the form of a ring. http://purl.obolibrary.org/obo/CHEBI_35406 oxoanion http://purl.obolibrary.org/obo/CHEBI_33273 polyatomic anion An oxoanion is an anion derived from an oxoacid by loss of hydron(s) bound to oxygen. http://purl.obolibrary.org/obo/CHEBI_36357 polyatomic entity http://purl.obolibrary.org/obo/CHEBI_23367 molecular entity Any molecular entity consisting of more than one atom. http://purl.obolibrary.org/obo/CHEBI_36358 polyatomic ion http://purl.obolibrary.org/obo/CHEBI_36357 polyatomic entity An ion consisting of more than one atom. http://purl.obolibrary.org/obo/CHEBI_36916 cation http://purl.obolibrary.org/obo/CHEBI_24870 ion A monoatomic or polyatomic species having one or more elementary charges of the proton. http://purl.obolibrary.org/obo/CHEBI_36962 organochalcogen compound http://purl.obolibrary.org/obo/CHEBI_33304 chalcogen molecular entity An organochalcogen compound is a compound containing at least one carbon-chalcogen bond. http://purl.obolibrary.org/obo/CHEBI_37577 heteroatomic molecular entity http://purl.obolibrary.org/obo/CHEBI_36357 polyatomic entity A molecular entity consisting of two or more chemical elements. http://purl.obolibrary.org/obo/CHEBI_83347 organosulfonic ester http://purl.obolibrary.org/obo/CHEBI_33424 sulfur oxoacid derivative An ester resulting from the formal condensation of the hydroxy group of an alcohol, phenol, heteroarenol, or enol with an organosulfonic acid. http://purl.obolibrary.org/obo/CHEBI_84055 pentose phosphate http://purl.obolibrary.org/obo/CHEBI_63367 monosaccharide derivative Any phospho sugar that is the phosphate derivative of pentose. http://purl.obolibrary.org/obo/CHEBI_37972 phosphorus-32 atom http://purl.obolibrary.org/obo/CHEBI_28659 phosphorus atom The radioactive isotope of phosphorus with relative atomic mass 31.973907 and half-life of 14.26 days. http://purl.obolibrary.org/obo/CHEBI_37973 phosphorus-33 atom http://purl.obolibrary.org/obo/CHEBI_28659 phosphorus atom The radioactive isotope of phosphorus with relative atomic mass 32.971725, half-life of 25.34 days and nuclear spin (1)/2. http://purl.obolibrary.org/obo/CHEBI_38313 diazines http://purl.obolibrary.org/obo/CHEBI_25693 organic heteromonocyclic compound Any organic heterocyclic compound containing a benzene ring in which two of the C-H fragments have been replaced by isolobal nitrogens (the diazine parent structure). http://purl.obolibrary.org/obo/CHEBI_42098 digoxigenin http://purl.obolibrary.org/obo/CHEBI_35348 3beta-sterol A hydroxy steroid that consists of 5beta-cardanolide having a double bond at the 20(22)-position as well as hydroxy groups at the 3beta-, 12beta- and 14beta-positions. It has been isolated from the plant species of the genus Digitalis. http://purl.obolibrary.org/obo/CHEBI_59050 dimethyl sulfate http://purl.obolibrary.org/obo/CHEBI_29281 alkyl sulfate The dimethyl ester of sulfuric acid. http://purl.obolibrary.org/obo/CHEBI_9754 tris http://purl.obolibrary.org/obo/CHEBI_50047 organic amino compound A primary amino compound that is tert-butylamine in which one hydrogen attached to each methyl group is replaced by a hydroxy group. A compound widely used as a biological buffer substance in the pH range 7--9; pKa = 8.3 at 20 degreeC; pKa = 7.82 at 37 degreeC. http://purl.obolibrary.org/obo/CHEBI_50076 chromium-51 http://purl.obolibrary.org/obo/CHEBI_28073 chromium atom A synthetic radioactive isotope of chromium having a half-life of 27.7 days and decaying by electron capture with emission of gamma rays (0.32 MeV); it is used to label red blood cells for measurement of mass or volume, survival time, and sequestration studies, for the diagnosis of gastrointestinal bleeding, and to label platelets to study their survival. http://purl.obolibrary.org/obo/CHEBI_61360 globoside http://purl.obolibrary.org/obo/CHEBI_24402 glycosphingolipid Any glycosphingolipid where the oligosaccharide component has an N-acetylgalactosaminyl residue at the non-reducing end. http://purl.obolibrary.org/obo/UBERON_0000310 breast http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure The upper ventral region of an animal's torso. http://purl.obolibrary.org/obo/PATO_0000051 morphology http://purl.obolibrary.org/obo/PATO_0001241 physical object quality A quality of a single physical entity inhering in the bearer by virtue of the bearer's size or shape or structure. http://purl.obolibrary.org/obo/PATO_0000117 size http://purl.obolibrary.org/obo/PATO_0000051 morphology A morphology quality inhering in a bearer by virtue of the bearer's physical magnitude. http://purl.obolibrary.org/obo/PATO_0000140 position http://purl.obolibrary.org/obo/PATO_0001018 physical quality A spatial quality inhering in a bearer by virtue of the bearer's spatial location relative to other objects in the vicinity. http://purl.obolibrary.org/obo/PATO_0000141 structure http://purl.obolibrary.org/obo/PATO_0000051 morphology A morphology quality inhering in a bearer by virtue of the bearer's relative position, shape, arrangements and connectivity of an organism's various parts; the pattern underlying its form. http://purl.obolibrary.org/obo/PATO_0000169 viability http://purl.obolibrary.org/obo/PATO_0001995 organismal quality An organismal quality inhering in a bearer or a population by virtue of the bearer's disposition to survive and develop normally or the number of surviving individuals in a given population. http://purl.obolibrary.org/obo/PATO_0001018 physical quality http://purl.obolibrary.org/obo/PATO_0001241 physical object quality A quality of a physical entity that exists through action of continuants at the physical level of organisation in relation to other entities. http://purl.obolibrary.org/obo/PATO_0001241 physical object quality http://purl.obolibrary.org/obo/BFO_0000019 quality A quality which inheres in a continuant. http://purl.obolibrary.org/obo/PATO_0001335 bacterial mating type http://purl.obolibrary.org/obo/PATO_0001895 mating type A mating type that indicates whether the F plasmid has integrated into the chromosome. http://purl.obolibrary.org/obo/PATO_0001337 yeast mating type http://purl.obolibrary.org/obo/PATO_0001895 mating type A yeast mating type. http://purl.obolibrary.org/obo/PATO_0001342 Saccharomyces cerevisiae mating type http://purl.obolibrary.org/obo/PATO_0001337 yeast mating type A S. cerevisiae mating type. http://purl.obolibrary.org/obo/PATO_0001343 Schizosaccharomyces pombe mating type http://purl.obolibrary.org/obo/PATO_0001337 yeast mating type A S. pombe mating type determined by the gene configuration on the mat1 locus. http://purl.obolibrary.org/obo/PATO_0001393 euploid http://purl.obolibrary.org/obo/PATO_0001374 ploidy A ploidy quality inhering in a bearer by virtue of the bearer's containing an integral multiple of the monoploid number, possibly excluding the sex-determining chromosomes. http://purl.obolibrary.org/obo/PATO_0001739 radiation quality http://purl.obolibrary.org/obo/PATO_0001018 physical quality A quality that inheres in an bearer by virtue of how that bearer interacts with radiation. http://purl.obolibrary.org/obo/PATO_0001895 mating type http://purl.obolibrary.org/obo/PATO_0000047 biological sex A biological sex quality inhering in an individual or a population that undergo sexual reproduction. http://purl.obolibrary.org/obo/PATO_0002198 quality of a substance http://purl.obolibrary.org/obo/PATO_0001018 physical quality A quality inhering in a bearer by virtue of its constitution. http://purl.obolibrary.org/obo/PO_0009012 plant structure development stage http://purl.obolibrary.org/obo/UBERON_0000105 life cycle stage A stage in the life of a plant structure (PO:0009011) during which the plant structure undergoes developmental processes. http://purl.obolibrary.org/obo/PO_0025131 plant anatomical entity http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity An anatomical entity that is or was part of a plant. http://purl.obolibrary.org/obo/UBERON_0001621 coronary artery http://purl.obolibrary.org/obo/UBERON_0003498 heart blood vessel An artery that supplies the myocardium. http://purl.obolibrary.org/obo/UBERON_0002385 muscle tissue http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure Muscle tissue is a contractile tissue made up of actin and myosin fibers[GO]. http://purl.obolibrary.org/obo/BFO_0000004 independent continuant http://purl.obolibrary.org/obo/BFO_0000002 continuant b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002]) http://purl.obolibrary.org/obo/BFO_0000015 process http://purl.obolibrary.org/obo/BFO_0000003 occurrent p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003]) http://purl.obolibrary.org/obo/BFO_0000020 specifically dependent continuant http://purl.obolibrary.org/obo/BFO_0000002 continuant b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003]) http://purl.obolibrary.org/obo/BFO_0000031 generically dependent continuant http://purl.obolibrary.org/obo/BFO_0000002 continuant b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001]) http://purl.obolibrary.org/obo/BFO_0000035 process boundary http://purl.obolibrary.org/obo/BFO_0000003 occurrent p is a process boundary =Def. p is a temporal part of a process & p has no proper temporal parts. (axiom label in BFO2 Reference: [084-001]) http://purl.obolibrary.org/obo/BFO_0000140 continuant fiat boundary http://purl.obolibrary.org/obo/BFO_0000141 immaterial entity b is a continuant fiat boundary = Def. b is an immaterial entity that is of zero, one or two dimensions and does not include a spatial region as part. (axiom label in BFO2 Reference: [029-001]) http://purl.obolibrary.org/obo/BFO_0000144 process profile http://purl.obolibrary.org/obo/BFO_0000015 process b is a process_profile =Def. there is some process c such that b process_profile_of c (axiom label in BFO2 Reference: [093-002]) http://purl.obolibrary.org/obo/BFO_0000145 relational quality http://purl.obolibrary.org/obo/BFO_0000019 quality b is a relational quality = Def. for some independent continuants c, d and for some time t: b quality_of c at t & b quality_of d at t. (axiom label in BFO2 Reference: [057-001]) http://purl.obolibrary.org/obo/OBI_0100026 organism http://purl.obolibrary.org/obo/BFO_0000040 material entity A material entity that is an individual living system, such as animal, plant, bacteria or virus, that is capable of replicating or reproducing, growth and maintenance in the right environment. An organism may be unicellular or made up, like humans, of many billions of cells divided into specialized tissues and organs. http://purl.obolibrary.org/obo/PATO_0000011 age http://purl.obolibrary.org/obo/PATO_0001018 physical quality A time quality inhering in a bearer by virtue of how long the bearer has existed. http://purl.obolibrary.org/obo/PATO_0000018 fluorescence http://purl.obolibrary.org/obo/PATO_0001739 radiation quality A luminous flux quality inhering in a bearer by virtue of the bearer's emitting longer wavelength light following the absorption of shorter wavelength radiation; fluorescence is common with aromatic compounds with several rings joined together. http://purl.obolibrary.org/obo/PATO_0000047 biological sex http://purl.obolibrary.org/obo/PATO_0001995 organismal quality An organismal quality inhering in a bearer by virtue of the bearer's ability to undergo sexual reproduction in order to differentiate the individuals or types involved. http://purl.obolibrary.org/obo/PATO_0000122 length http://purl.obolibrary.org/obo/PATO_0000117 size A 1-D extent quality which is equal to the distance between two points. http://purl.obolibrary.org/obo/PATO_0000125 mass http://purl.obolibrary.org/obo/PATO_0001018 physical quality A physical quality that inheres in a bearer by virtue of the proportion of the bearer's amount of matter. http://purl.obolibrary.org/obo/PATO_0000146 temperature http://purl.obolibrary.org/obo/PATO_0001018 physical quality A physical quality of the thermal energy of a system. http://purl.obolibrary.org/obo/PATO_0000186 behavioral quality http://purl.obolibrary.org/obo/PATO_0001995 organismal quality An organismal quality inhering in a bearer by virtue of the bearer's behavior aggregate of the responses or reactions or movements in a given situation. http://purl.obolibrary.org/obo/PATO_0000383 female http://purl.obolibrary.org/obo/PATO_0001894 phenotypic sex A biological sex quality inhering in an individual or a population that only produces gametes that can be fertilised by male gametes. http://purl.obolibrary.org/obo/PATO_0000384 male http://purl.obolibrary.org/obo/PATO_0001894 phenotypic sex A biological sex quality inhering in an individual or a population whose sex organs contain only male gametes. http://purl.obolibrary.org/obo/PATO_0000918 volume http://purl.obolibrary.org/obo/PATO_0000117 size A 3-D extent quality inhering in a bearer by virtue of the bearer's amount of 3-dimensional space it occupies. http://purl.obolibrary.org/obo/PATO_0001025 pressure http://purl.obolibrary.org/obo/PATO_0001018 physical quality A physical quality that inheres in a bearer by virtue of the bearer's amount of force per unit area it exerts. http://purl.obolibrary.org/obo/PATO_0001161 diluted http://purl.obolibrary.org/obo/PATO_0001241 physical object quality A concentration which relatively low. http://purl.obolibrary.org/obo/PATO_0001167 damaged http://purl.obolibrary.org/obo/PATO_0000141 structure A structural quality inhering in a bearer by virtue of the bearer being harmed or injured or spoiled, such that its functionality is impaired. http://purl.obolibrary.org/obo/PATO_0001193 lateral to http://purl.obolibrary.org/obo/PATO_0000140 position A spatial quality inhering in a bearer by virtue of the bearer's being located toward the side relative to another entity. http://purl.obolibrary.org/obo/PATO_0001196 ventral to http://purl.obolibrary.org/obo/PATO_0000140 position A spatial quality inhering in a bearer by virtue of the bearer's being located toward the abdomen of an organism relative to another entity. http://purl.obolibrary.org/obo/PATO_0001233 dorsal to http://purl.obolibrary.org/obo/PATO_0000140 position A spatial quality inhering in a bearer by virtue of the bearer's being located toward the back or upper surface of an organism relative to another entity. http://purl.obolibrary.org/obo/PATO_0001338 mixed sex http://purl.obolibrary.org/obo/PATO_0001241 physical object quality A biological sex quality inhering in a population of multiple sexes. http://purl.obolibrary.org/obo/PATO_0001339 biomaterial purity http://purl.obolibrary.org/obo/PATO_0000141 structure A composition quality inhering in an bearer by virtue of the bearer's homogeneity of a biomaterial. http://purl.obolibrary.org/obo/PATO_0001340 hermaphrodite http://purl.obolibrary.org/obo/PATO_0001894 phenotypic sex A biological sex quality inhering in an organism or a population with both male and female sexual organs in one individual. http://purl.obolibrary.org/obo/PATO_0001341 a mating type (yeast) http://purl.obolibrary.org/obo/PATO_0001342 Saccharomyces cerevisiae mating type A S. cerevisiae mating type cells that secrete a pheromone that in alpha haploids stimulates processes that lead to mating. http://purl.obolibrary.org/obo/PATO_0001344 alpha mating type (yeast) http://purl.obolibrary.org/obo/PATO_0001342 Saccharomyces cerevisiae mating type A S. cerevisiae mating type cells that secrete a pheromone that stimulates a haploids. http://purl.obolibrary.org/obo/PATO_0001345 h minus http://purl.obolibrary.org/obo/PATO_0001343 Schizosaccharomyces pombe mating type A S. pombe mating type determined by the mat1-Mc and mat1-Mi on the mat1 locus. http://purl.obolibrary.org/obo/PATO_0001346 h plus http://purl.obolibrary.org/obo/PATO_0001343 Schizosaccharomyces pombe mating type A S. pombe mating type determined by the mat1-Pc and mat1-Pi on the mat1 locus. http://purl.obolibrary.org/obo/PATO_0001347 F mating type http://purl.obolibrary.org/obo/PATO_0001335 bacterial mating type A bacterial mating type indicating the presence of F plasmid in a bacterial cell. http://purl.obolibrary.org/obo/PATO_0001348 F minus mating type http://purl.obolibrary.org/obo/PATO_0001335 bacterial mating type A bacterial mating type indicating the absence of F plasmid in a bacterial cell. http://purl.obolibrary.org/obo/PATO_0001374 ploidy http://purl.obolibrary.org/obo/PATO_0001396 cellular quality A cellular quality inhering in a bearer by virtue of the bearer's number of homologous sets of chromosomes in the nucleus or primary chromosome-containing compartment of the cell, each set essentially coding for all the biological traits of the organism. http://purl.obolibrary.org/obo/PATO_0001375 haploid http://purl.obolibrary.org/obo/PATO_0001393 euploid A ploidy quality inhering in a bearer by virtue of the bearer's containing a single set of homologous chromosomes. http://purl.obolibrary.org/obo/PATO_0001377 polyploid http://purl.obolibrary.org/obo/PATO_0001393 euploid A ploidy quality inhering in a bearer by virtue of the bearer's containing more than two homologous sets of chromosomes. http://purl.obolibrary.org/obo/PATO_0001385 aneuploid http://purl.obolibrary.org/obo/PATO_0001374 ploidy A ploidy quality inhering in a bearer by virtue of the bearer's containing a non-integral multiple of the monoploid number, due to extra or missing chromosomes. http://purl.obolibrary.org/obo/PATO_0001394 diploid http://purl.obolibrary.org/obo/PATO_0001393 euploid A ploidy quality inhering in a bearer by virtue of the bearer's having two copies (homologs) of each chromosome, usually one from the mother and one from the father. http://purl.obolibrary.org/obo/PATO_0001396 cellular quality http://purl.obolibrary.org/obo/PATO_0001241 physical object quality A monadic quality of continuant that exists at the cellular level of organisation. http://purl.obolibrary.org/obo/PATO_0001421 alive http://purl.obolibrary.org/obo/PATO_0000169 viability A viability quality inhering in a bearer by virtue of the bearer's condition before death. http://purl.obolibrary.org/obo/PATO_0001422 dead http://purl.obolibrary.org/obo/PATO_0000169 viability A viability quality inhering in a bearer by virtue of the cessation of the bearer's life. http://purl.obolibrary.org/obo/PATO_0001546 quality of a solid http://purl.obolibrary.org/obo/PATO_0002198 quality of a substance A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity characterized by particles arranged such that their shape and volume are relatively stable. http://purl.obolibrary.org/obo/PATO_0001547 quality of a gas http://purl.obolibrary.org/obo/PATO_0002198 quality of a substance A physical quality inhering in a bearer by virtue of the bearer's exhibiting the physical characteristics of an entity consisting of particles that have neither a defined volume nor defined shape. http://purl.obolibrary.org/obo/PATO_0001548 quality of a liquid http://purl.obolibrary.org/obo/PATO_0002198 quality of a substance A physical quality inhering in an entity exhibiting the physical characteristics of an amorphous (non-crystalline) form of matter between a gas and a solid that has a definite volume, but no definite shape. http://purl.obolibrary.org/obo/PATO_0001632 anterior to http://purl.obolibrary.org/obo/PATO_0000140 position A spatial quality inhering in a bearer by virtue of the bearer's being located toward the front of an organism relative to another entity. http://purl.obolibrary.org/obo/PATO_0001741 radioactive http://purl.obolibrary.org/obo/PATO_0001739 radiation quality A radiation quality inhering in bearer by virtue of the bearer's exhibiting or being caused by radioactivity. http://purl.obolibrary.org/obo/PATO_0001792 left side of http://purl.obolibrary.org/obo/PATO_0000140 position A spatial quality inhering in a bearer by virtue of the bearer's being located on left side of from the a another entity. http://purl.obolibrary.org/obo/PATO_0001793 right side of http://purl.obolibrary.org/obo/PATO_0000140 position A spatial quality inhering in a bearer by virtue of the bearer's being located on right side of a another entity. http://purl.obolibrary.org/obo/PATO_0001985 frozen http://purl.obolibrary.org/obo/PATO_0000146 temperature A quality inhering in a bearer by virtue of the bearer's being kept below its freezing point. http://purl.obolibrary.org/obo/PATO_0001995 organismal quality http://purl.obolibrary.org/obo/PATO_0001241 physical object quality A quality that inheres in an entire organism or part of an organism. http://purl.obolibrary.org/obo/PATO_0002201 handedness http://purl.obolibrary.org/obo/PATO_0000186 behavioral quality A behavioral quality inhering ina bearer by virtue of the bearer's unequal distribution of fine motor skill between its left and right hands or feet. http://purl.obolibrary.org/obo/PATO_0002202 left handedness http://purl.obolibrary.org/obo/PATO_0002201 handedness Handedness where the organism preferentially uses the left hand or foot for tasks requiring the use of a single hand or foot or a dominant hand or foot. http://purl.obolibrary.org/obo/PATO_0002203 right handedness http://purl.obolibrary.org/obo/PATO_0002201 handedness Handedness where the organism preferentially uses the right hand or foot for tasks requiring the use of a single hand or foot or a dominant hand or foot. http://purl.obolibrary.org/obo/PATO_0002204 ambidextrous handedness http://purl.obolibrary.org/obo/PATO_0002201 handedness Handedness where the organism exhibits no overall dominance in the use of right or left hand or foot in the performance of tasks that require one hand or foot or a dominant hand or foot. http://purl.obolibrary.org/obo/PATO_0002243 fluid flow rate http://purl.obolibrary.org/obo/PATO_0001018 physical quality A physical quality inhering in a fluid (liquid or gas) by virtue of the amount of fluid which passes through a given surface per unit time. http://purl.obolibrary.org/obo/PR_000000001 protein http://purl.obolibrary.org/obo/CHEBI_23367 molecular entity An amino acid chain that is produced de novo by ribosome-mediated translation of a genetically-encoded mRNA. http://purl.obolibrary.org/obo/PR_000001004 CD4 molecule http://purl.obolibrary.org/obo/PR_000000001 protein A protein that is a translation product of the human CD4 gene or a 1:1 ortholog thereof. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It is the primary receptor for HIV-1. CD4 has four immunoglobulin-like domains in its extracellular region that share the same structure, but can differ in sequence. http://purl.obolibrary.org/obo/PR_000001018 CD3 subunit with immunoglobulin domain http://purl.obolibrary.org/obo/PR_000000001 protein A protein with a core domain composition consisting of an extracellular N-terminal domain that adopts an immunoglobulin fold, a transmembrane domain, and an intracellular C-terminal domain with a single copy of the Immunoreceptor tyrosine-based activation motif (Pfam:PF02189) (ITAM). It constitutes the invariant subunit of the T cell antigen receptor (TCR). TCR is a surface receptor on T cells responsible for recognizing MHC-restricted antigens and initiating the cellular immune response. http://purl.obolibrary.org/obo/PR_000003252 antithrombin-III http://purl.obolibrary.org/obo/PR_000000001 protein A serpin that is a translation product of the human SERPINC1 gene or a 1:1 ortholog thereof. http://purl.obolibrary.org/obo/PR_000003745 double-stranded RNA-specific adenosine deaminase http://purl.obolibrary.org/obo/PR_000000001 protein A protein that is a translation product of the human ADAR gene or a 1:1 ortholog thereof. http://purl.obolibrary.org/obo/PR_000006592 deoxyribonuclease-1 http://purl.obolibrary.org/obo/PR_000000001 protein A protein that is a translation product of the human DNASE1 gene or a 1:1 ortholog thereof. http://purl.obolibrary.org/obo/PR_000007928 glial cell line-derived neurotrophic factor http://purl.obolibrary.org/obo/PR_000000001 protein A protein that is a translation product of the human GDNF gene or a 1:1 ortholog thereof. http://purl.obolibrary.org/obo/PR_000014060 ribonuclease T2 http://purl.obolibrary.org/obo/PR_000000001 protein A protein that is a translation product of the human RNASET2 gene or a 1:1 ortholog thereof. http://purl.obolibrary.org/obo/PR_000023089 DNA ligase http://purl.obolibrary.org/obo/PR_000000001 protein A protein that is a translation product of the Escherichia coli K-12 ligA gene or a 1:1 ortholog thereof. http://purl.obolibrary.org/obo/PR_000025402 T cell receptor co-receptor CD8 http://purl.obolibrary.org/obo/CHEBI_23367 molecular entity A protein complex that is a membrane-bound heterodimeric co-receptor for MHC class-I antigen/T-cell receptor interaction. http://purl.obolibrary.org/obo/PR_000025467 guanyl-specific ribonuclease T1 http://purl.obolibrary.org/obo/PR_000000001 protein A protein that is a translation product of the Aspergillus oryzae rntA gene or a 1:1 ortholog thereof. http://purl.obolibrary.org/obo/PR_000025471 nuclease S1 http://purl.obolibrary.org/obo/PR_000000001 protein A protein that is a translation product of the Aspergillus oryzae nucS gene or a 1:1 ortholog thereof. http://purl.obolibrary.org/obo/PR_000025475 ribonuclease U2 http://purl.obolibrary.org/obo/PR_000000001 protein A protein that is a translation product of the Ustilago sphaerogena RNU2 gene or a 1:1 ortholog thereof. http://purl.obolibrary.org/obo/PR_000025477 ribonuclease V1 http://purl.obolibrary.org/obo/PR_000000001 protein A protein with ribonuclease activity that is a constituent of cobra venom. http://purl.obolibrary.org/obo/PR_000025478 ribonuclease CL3 http://purl.obolibrary.org/obo/PR_000000001 protein A protein with ribonuclease activity that is purified from chicken liver. http://purl.obolibrary.org/obo/CHEBI_26912 oxolanes http://purl.obolibrary.org/obo/CHEBI_38104 oxacycle Any oxacycle having an oxolane (tetrahydrofuran) skeleton. http://purl.obolibrary.org/obo/CHEBI_36834 3-hydroxy steroid http://purl.obolibrary.org/obo/CHEBI_35350 hydroxy steroid Any hydroxy steroid carrying a hydroxy group at position 3. http://purl.obolibrary.org/obo/CHEBI_17709 5'-adenylyl sulfate http://purl.obolibrary.org/obo/CHEBI_37875 acyl sulfate An adenosine 5'-phosphate having a sulfo group attached to one the phosphate OH groups. http://purl.obolibrary.org/obo/CHEBI_50047 organic amino compound http://purl.obolibrary.org/obo/CHEBI_50860 organic molecular entity A compound formally derived from ammonia by replacing one, two or three hydrogen atoms by organyl groups. http://purl.obolibrary.org/obo/CHEBI_15956 biotin http://purl.obolibrary.org/obo/CHEBI_51570 biotins An organic heterobicyclic compound that consists of 2-oxohexahydro-1H-thieno[3,4-d]imidazole having a valeric acid substituent attached to the tetrahydrothiophene ring. The parent of the class of biotins. http://purl.obolibrary.org/obo/CHEBI_15986 polynucleotide http://purl.obolibrary.org/obo/CHEBI_33694 biomacromolecule A nucleobase-containing molecular entity with a polymeric structure comprised of a linear sequence of 13 or more nucleotide residues. http://purl.obolibrary.org/obo/CHEBI_16247 phospholipid http://purl.obolibrary.org/obo/CHEBI_37734 phosphoric ester A lipid containing phosphoric acid as a mono- or di-ester. The term encompasses phosphatidic acids and phosphoglycerides. http://purl.obolibrary.org/obo/CHEBI_16991 deoxyribonucleic acid http://purl.obolibrary.org/obo/CHEBI_33696 nucleic acid High molecular weight, linear polymers, composed of nucleotides containing deoxyribose and linked by phosphodiester bonds; DNA contain the genetic information of organisms. http://purl.obolibrary.org/obo/CHEBI_17234 glucose http://purl.obolibrary.org/obo/CHEBI_78616 carbohydrates and carbohydrate derivatives An aldohexose used as a source of energy and metabolic intermediate. http://purl.obolibrary.org/obo/CHEBI_18292 jasmonic acid http://purl.obolibrary.org/obo/CHEBI_35871 oxo monocarboxylic acid An oxo monocarboxylic acid that is (3-oxocyclopentyl)acetic acid substituted by a (2Z)-pent-2-en-1-yl group at position 2 of the cyclopentane ring. http://purl.obolibrary.org/obo/CHEBI_25704 organic sulfate http://purl.obolibrary.org/obo/CHEBI_37826 sulfuric acid derivative Compounds of the general formula SO3HOR where R is an organyl group http://purl.obolibrary.org/obo/CHEBI_26819 sulfuric ester http://purl.obolibrary.org/obo/CHEBI_37826 sulfuric acid derivative An ester of an alcohol and sulfuric acid. http://purl.obolibrary.org/obo/CHEBI_30879 alcohol http://purl.obolibrary.org/obo/CHEBI_33822 organic hydroxy compound A compound in which a hydroxy group, -OH, is attached to a saturated carbon atom. http://purl.obolibrary.org/obo/CHEBI_33447 phospho sugar http://purl.obolibrary.org/obo/CHEBI_63367 monosaccharide derivative Any monosaccharide containing an alcoholic hydroxy group esterified with phosphoric acid. http://purl.obolibrary.org/obo/CHEBI_33696 nucleic acid http://purl.obolibrary.org/obo/CHEBI_15986 polynucleotide A macromolecule made up of nucleotide units and hydrolysable into certain pyrimidine or purine bases (usually adenine, cytosine, guanine, thymine, uracil), D-ribose or 2-deoxy-D-ribose and phosphoric acid. http://purl.obolibrary.org/obo/CHEBI_33709 amino acid http://purl.obolibrary.org/obo/CHEBI_33575 carboxylic acid A carboxylic acid containing one or more amino groups. http://purl.obolibrary.org/obo/CHEBI_33838 nucleoside http://purl.obolibrary.org/obo/CHEBI_21731 N-glycosyl compound An N-glycosyl compound that has both a nucleobase, normally adenine, guanine, xanthine, thymine, cytosine or uracil, and either a ribose or deoxyribose as functional parents. http://purl.obolibrary.org/obo/CHEBI_63299 carbohydrate derivative http://purl.obolibrary.org/obo/CHEBI_78616 carbohydrates and carbohydrate derivatives Any organooxygen compound derived from a carbohydrate by replacement of one or more hydroxy group(s) by an amino group, a thiol group or similar heteroatomic groups. The term also includes derivatives of these compounds. http://purl.obolibrary.org/obo/CHEBI_72695 organic molecule http://purl.obolibrary.org/obo/CHEBI_50860 organic molecular entity Any molecule that consists of at least one carbon atom as part of the electrically neutral entity. http://purl.obolibrary.org/obo/CHEBI_29237 deuterium atom http://purl.obolibrary.org/obo/CHEBI_49637 hydrogen atom The stable isotope of hydrogen with relative atomic mass 2.014102 and a natural abundance of 0.0115 atom percent (from Greek deltaepsilonupsilontauepsilonrhoomicronnu, second). http://purl.obolibrary.org/obo/CHEBI_59052 1,1-dihydroxy-3-ethoxy-2-butanone http://purl.obolibrary.org/obo/CHEBI_36586 carbonyl compound A butanone derivative having two hydroxy substituents at the 1-position and an ethoxy substituent at the 3-position. http://purl.obolibrary.org/obo/CHEBI_59053 N-cyclohexyl-N'-(2-(4-morpholinyl)ethyl)carbodiimide http://purl.obolibrary.org/obo/CHEBI_35352 organonitrogen compound A carbodiimide having cyclcohexyl and 2-(4-morpholinyl)ethyl as the two N-substituents. http://purl.obolibrary.org/obo/CHEBI_59054 N-methylisatoic anhydride http://purl.obolibrary.org/obo/CHEBI_46969 benzoxazine A 3,1-benzoxazin-1,4-dione having an N-methyl substituent. http://purl.obolibrary.org/obo/CHEBI_59055 (S)-1-(4-bromoacetamidobenzyl)EDTA http://purl.obolibrary.org/obo/CHEBI_35742 tetracarboxylic acid A tetracarboxylic acid consisting of ethylenediaminetetraacetic acid having a 4-bromoacetamidobenzyl group at the C1-position and (S)-configuration. http://purl.obolibrary.org/obo/CHEBI_59056 EDTA methidiumpropylamide http://purl.obolibrary.org/obo/CHEBI_39206 dibenzopyridine A combined intercalating and chelating reagent. The iron chelate, prepared by adding Fe(NH4)2(SO4)2, effects random oxidative cleavage of DNA in the presence of O2 and a reducing agent. This activity is useful as a footprinting probe. http://purl.obolibrary.org/obo/CHEBI_59424 bromophenol blue http://purl.obolibrary.org/obo/CHEBI_37141 organobromine compound 3H-2,1-Benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 3,5-dibromo-4-hydroxyphenyl groups. It is used as a laboratory indicator, changing from yellow below pH 3 to purple at pH 4.6, and as a size marker for monitoring the progress of agarose gel and polyacrylamide gel electrophoresis. It has also been used as an industrial dye. http://purl.obolibrary.org/obo/DOID_4 disease http://purl.obolibrary.org/obo/BFO_0000016 disposition A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism. http://purl.obolibrary.org/obo/UBERON_0000948 heart http://purl.obolibrary.org/obo/UBERON_0005177 trunk region element A myogenic muscular circulatory organ found in the vertebrate cardiovascular system composed of chambers of cardiac muscle. It is the primary circulatory organ. http://purl.obolibrary.org/obo/UBERON_0000955 brain http://purl.obolibrary.org/obo/UBERON_0000062 organ The brain is the center of the nervous system in all vertebrate, and most invertebrate, animals. Some primitive animals such as jellyfish and starfish have a decentralized nervous system without a brain, while sponges lack any nervous system at all. In vertebrates, the brain is located in the head, protected by the skull and close to the primary sensory apparatus of vision, hearing, balance, taste, and smell[WP]. http://purl.obolibrary.org/obo/UBERON_0001134 skeletal muscle tissue http://purl.obolibrary.org/obo/UBERON_0002385 muscle tissue Muscle tissue that consists primarily of skeletal muscle fibers. http://purl.obolibrary.org/obo/UBERON_0001323 tibial nerve http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity The tibial nerve is a branch of the sciatic nerve. The tibial nerve passes through the popliteal fossa to pass below the arch of soleus. In the popliteal fossa the nerve gives off branches to gastrocnemius, popliteus, soleus and plantaris muscles, an articular branch to the knee joint, and a cutaneous branch that will become the sural nerve. The sural nerve is joined by fibres from the common peroneal nerve and runs down the calf to supply the lateral side of the foot. Below the soleus muscle the nerve lies close to the tibia and supplies the tibialis posterior, the flexor digitorum longus and the flexor hallucis longus. The nerve passes into the foot running posterior to the medial malleolus. Here it is bound down by the flexor retinaculum in company with the posterior tibial artery. [WP,unvetted]. http://purl.obolibrary.org/obo/UBERON_0002107 liver http://purl.obolibrary.org/obo/UBERON_0006925 digestive gland An exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes[GO]. http://purl.obolibrary.org/obo/CHEBI_16670 peptide http://purl.obolibrary.org/obo/CHEBI_37622 carboxamide Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from alpha-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc. http://purl.obolibrary.org/obo/CHEBI_21731 N-glycosyl compound http://purl.obolibrary.org/obo/CHEBI_35352 organonitrogen compound A glycosyl compound arising formally from the elimination of water from a glycosidic hydroxy group and an H atom bound to a nitrogen atom, thus creating a C-N bond. http://purl.obolibrary.org/obo/CHEBI_24828 indoles http://purl.obolibrary.org/obo/CHEBI_22728 benzopyrrole Any compound containing an indole skeleton. http://purl.obolibrary.org/obo/CHEBI_25384 monocarboxylic acid http://purl.obolibrary.org/obo/CHEBI_33575 carboxylic acid An oxoacid containing a single carboxy group. http://purl.obolibrary.org/obo/CHEBI_26979 organic heterotricyclic compound http://purl.obolibrary.org/obo/CHEBI_33671 heteropolycyclic compound An organic tricyclic compound in which at least one of the rings of the tricyclic skeleton contains one or more heteroatoms. http://purl.obolibrary.org/obo/CHEBI_33308 carboxylic ester http://purl.obolibrary.org/obo/CHEBI_35701 ester An ester of a carboxylic acid, R(1)C(=O)OR(2), where R(1) = H or organyl and R(2) = organyl. http://purl.obolibrary.org/obo/CHEBI_33551 organosulfonic acid http://purl.obolibrary.org/obo/CHEBI_33552 sulfonic acid derivative An organic derivative of sulfonic acid in which the sulfo group is linked directly to carbon. http://purl.obolibrary.org/obo/CHEBI_33575 carboxylic acid http://purl.obolibrary.org/obo/CHEBI_35605 carbon oxoacid A carbon oxoacid acid carrying at least one -C(=O)OH group and having the structure RC(=O)OH, where R is any any monovalent functional group. Carboxylic acids are the most common type of organic acid. http://purl.obolibrary.org/obo/CHEBI_33833 heteroarene http://purl.obolibrary.org/obo/CHEBI_33659 organic aromatic compound A heterocyclic compound formally derived from an arene by replacement of one or more methine (-C=) and/or vinylene (-CH=CH-) groups by trivalent or divalent heteroatoms, respectively, in such a way as to maintain the continuous pi-electron system characteristic of aromatic systems and a number of out-of-plane pi-electrons corresponding to the Hueckel rule (4n+2). http://purl.obolibrary.org/obo/CHEBI_33853 phenols http://purl.obolibrary.org/obo/CHEBI_33659 organic aromatic compound Organic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring. http://purl.obolibrary.org/obo/CHEBI_35352 organonitrogen compound http://purl.obolibrary.org/obo/CHEBI_51143 nitrogen molecular entity Any heteroorganic entity containing at least one carbon-nitrogen bond. http://purl.obolibrary.org/obo/CHEBI_35742 tetracarboxylic acid http://purl.obolibrary.org/obo/CHEBI_33575 carboxylic acid An oxoacid containing four carboxy groups. http://purl.obolibrary.org/obo/CHEBI_35871 oxo monocarboxylic acid http://purl.obolibrary.org/obo/CHEBI_33575 carboxylic acid Any monocarboxylic acid having at least one additional oxo functional group. http://purl.obolibrary.org/obo/CHEBI_36586 carbonyl compound http://purl.obolibrary.org/obo/CHEBI_36963 organooxygen compound Any compound containing the carbonyl group, C=O. The term is commonly used in the restricted sense of aldehydes and ketones, although it actually includes carboxylic acids and derivatives. http://purl.obolibrary.org/obo/CHEBI_36684 organohalogen compound http://purl.obolibrary.org/obo/CHEBI_37578 halide A compound containing at least one carbon-halogen bond. http://purl.obolibrary.org/obo/CHEBI_36963 organooxygen compound http://purl.obolibrary.org/obo/CHEBI_36962 organochalcogen compound An organochalcogen compound containing at least one carbon-oxygen bond. http://purl.obolibrary.org/obo/CHEBI_37622 carboxamide http://purl.obolibrary.org/obo/CHEBI_33256 primary amide An amide of a carboxylic acid, having the structure RC(=O)NR2. The term is used as a suffix in systematic name formation to denote the -C(=O)NH2 group including its carbon atom. http://purl.obolibrary.org/obo/CHEBI_38104 oxacycle http://purl.obolibrary.org/obo/CHEBI_36963 organooxygen compound Any organic heterocyclic compound containing at least one ring oxygen atom. http://purl.obolibrary.org/obo/CHEBI_50860 organic molecular entity http://purl.obolibrary.org/obo/CHEBI_33582 carbon group molecular entity Any molecular entity that contains carbon. http://purl.obolibrary.org/obo/CHEBI_63367 monosaccharide derivative http://purl.obolibrary.org/obo/CHEBI_63299 carbohydrate derivative A carbohydrate derivative that is formally obtained from a monosaccharide. http://purl.obolibrary.org/obo/CHEBI_18348 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate http://purl.obolibrary.org/obo/CHEBI_37739 glycerophospholipid A phosphatidylinositol bisphosphate in which the two phosphate groups are at C-4 and C-5 of the inositol moiety which has the 1D-myo configuration. http://purl.obolibrary.org/obo/CHEBI_26401 purines http://purl.obolibrary.org/obo/CHEBI_35875 imidazopyrimidine A class of imidazopyrimidines that consists of purine and its substituted derivatives. http://purl.obolibrary.org/obo/CHEBI_16412 lipopolysaccharide http://purl.obolibrary.org/obo/CHEBI_35740 liposaccharide Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria). http://purl.obolibrary.org/obo/CHEBI_17761 ceramide http://purl.obolibrary.org/obo/CHEBI_26739 sphingolipid Ceramides (N-acyl-sphingoid bases) are a major subclass of sphingoid base derivatives with an amide-linked fatty acid. The fatty acids are typically saturated or monounsaturated with chain lengths from 14 to 26 carbon atoms; the presence of a hydroxyl group on carbon 2 is fairly common. Ceramides are generally precursors of more complex sphingolipids. In the illustrated generalised structure, R(1) = OH, OX (where X = acyl, glycosyl, phosphate, phosphonate, etc.), or H. http://purl.obolibrary.org/obo/CHEBI_18259 N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide http://purl.obolibrary.org/obo/CHEBI_88167 N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide A glycotetraosylceramide having N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucose as the tetrasaccharide component. http://purl.obolibrary.org/obo/CHEBI_16411 indole-3-acetic acid http://purl.obolibrary.org/obo/CHEBI_46867 indolyl carboxylic acid A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens has been replaced by a 1H-indol-3-yl group. http://purl.obolibrary.org/obo/CHEBI_25078 luciferin http://purl.obolibrary.org/obo/BFO_0000023 role A low-molecular-mass compound present in bioluminescent organisms that emits light when oxidized in presence of enzyme luciferase. http://purl.obolibrary.org/obo/CHEBI_25608 nucleoside phosphate http://purl.obolibrary.org/obo/CHEBI_37734 phosphoric ester A nucleobase-containing molecular entity that is a nucleoside in which one or more of the sugar hydroxy groups has been converted into a mono- or poly-phosphate. The term includes both nucleotides and non-nucleotide nucleoside phosphates. http://purl.obolibrary.org/obo/CHEBI_26523 reactive oxygen species http://purl.obolibrary.org/obo/CHEBI_25806 oxygen molecular entity Molecules or ions formed by the incomplete one-electron reduction of oxygen. They contribute to the microbicidal activity of phagocytes, regulation of signal transduction and gene expression, and the oxidative damage to biopolymers. http://purl.obolibrary.org/obo/CHEBI_33256 primary amide http://purl.obolibrary.org/obo/CHEBI_51143 nitrogen molecular entity A derivative of an oxoacid RkE(=O)l(OH)m (l =/= 0) in which an acidic hydroxy group has been replaced by an amino or substituted amino group. http://purl.obolibrary.org/obo/CHEBI_33839 macromolecule http://purl.obolibrary.org/obo/CHEBI_36357 polyatomic entity A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. http://purl.obolibrary.org/obo/CHEBI_35701 ester http://purl.obolibrary.org/obo/CHEBI_36963 organooxygen compound A compound formally derived from an oxoacid RkE(=O)l(OH)m (l > 0) and an alcohol, phenol, heteroarenol, or enol by linking with formal loss of water from an acidic hydroxy group of the former and a hydroxy group of the latter. http://purl.obolibrary.org/obo/CHEBI_37739 glycerophospholipid http://purl.obolibrary.org/obo/CHEBI_16247 phospholipid Any glycerolipid having a phosphate group ester-linked to a terminal carbon of the glycerol backbone. http://purl.obolibrary.org/obo/CHEBI_51570 biotins http://purl.obolibrary.org/obo/CHEBI_38297 thiabicycloalkane Compounds containing a biotin (5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoic acid) skeleton. http://purl.obolibrary.org/obo/CHEBI_61295 guanyl ribonucleotide http://purl.obolibrary.org/obo/CHEBI_26400 purine ribonucleotide A purine ribonucleotide where the purine is guanine. http://purl.obolibrary.org/obo/CHEBI_78616 carbohydrates and carbohydrate derivatives http://purl.obolibrary.org/obo/CHEBI_36963 organooxygen compound Any organooxygen compound that is a polyhydroxy-aldehyde or -ketone, or a compound derived from one. Carbohydrates contain only carbon, hydrogen and oxygen and usually have an empirical formula Cm(H2O)n; carbohydrate derivatives may contain other elements by substitution or condensation. http://purl.obolibrary.org/obo/CHEBI_26739 sphingolipid http://purl.obolibrary.org/obo/CHEBI_36963 organooxygen compound Sphingolipids are a complex family of compounds that share a common structural feature, a sphingoid base backbone. http://purl.obolibrary.org/obo/CHEBI_33694 biomacromolecule http://purl.obolibrary.org/obo/CHEBI_33839 macromolecule A macromolecule formed by a living organism. http://purl.obolibrary.org/obo/CHEBI_33697 ribonucleic acid http://purl.obolibrary.org/obo/CHEBI_33696 nucleic acid High molecular weight, linear polymers, composed of nucleotides containing ribose and linked by phosphodiester bonds; RNA is central to the synthesis of proteins. http://purl.obolibrary.org/obo/CHEBI_37578 halide http://purl.obolibrary.org/obo/CHEBI_37577 heteroatomic molecular entity Any heteroatomic molecular entity that is a chemical compound of halogen with other chemical elements. http://purl.obolibrary.org/obo/CHEBI_61073 oxygen radical http://purl.obolibrary.org/obo/CHEBI_36871 inorganic radical An inorganic radical in which a free electron resides on one or more oxygen atoms of an oxygen species. http://purl.obolibrary.org/obo/CHEBI_61296 adenyl ribonucleotide http://purl.obolibrary.org/obo/CHEBI_26400 purine ribonucleotide A purine riboncleotide where adenine is the purine. http://purl.obolibrary.org/obo/CHEBI_68472 pyrimidine deoxyribonucleoside http://purl.obolibrary.org/obo/CHEBI_26440 pyrimidine nucleoside A deoxyribonucleoside containing a pyrimidine base. http://purl.obolibrary.org/obo/CHEBI_88167 N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-ceramide http://purl.obolibrary.org/obo/CHEBI_61360 globoside A glycotetraosylceramide having N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl component attached to the primary hydroxy function of a ceramide with undefined sphingoid base. http://purl.obolibrary.org/obo/CHEBI_31642 gadodiamide hydrate http://purl.obolibrary.org/obo/CHEBI_35730 gadolinium coordination entity The hydrate of gadodiamide. http://purl.obolibrary.org/obo/CHEBI_31643 gadoteridol http://purl.obolibrary.org/obo/CHEBI_35730 gadolinium coordination entity A non-ionic gadolinium chelate having a macrocyclic tetraamine framework. It is used as a paramagnetic contrast agent in magnetic resonance imaging (MRI). http://purl.obolibrary.org/obo/CHEBI_31991 phenol red http://purl.obolibrary.org/obo/CHEBI_38094 arenesulfonate ester 3H-2,1-Benzoxathiole 1,1-dioxide in which both of the hydrogens at position 3 have been substituted by 4-hydroxyphenyl groups. A pH indicator changing colour from yellow below pH 6.8 to bright pink above pH 8.2, it is commonly used as an indicator in cell cultures and in home swimming pool test kits. It is also used in the (now infrequently performed) phenolsulfonphthalein (PSP) test for estimation of overall blood flow through the kidney. http://purl.obolibrary.org/obo/CHEBI_32142 sodium citrate dihydrate http://purl.obolibrary.org/obo/CHEBI_35505 hydrate The dihydrate of trisodium citrate. http://purl.obolibrary.org/obo/CHEBI_37333 gadodiamide http://purl.obolibrary.org/obo/CHEBI_35730 gadolinium coordination entity A non-ionic gadolinium chelate having a macrocyclic triamine framework. It is used as a paramagnetic contrast agent in magnetic resonance imaging (MRI). http://purl.obolibrary.org/obo/CHEBI_37960 cyanine dye http://purl.obolibrary.org/obo/CHEBI_35352 organonitrogen compound Cyanine dyes are synthetic dyes with the general formula R2N[CH=CH]nCH=N(+)R2 <-> R2N(+)=CH[CH=CH]nNR2 (n is a small number) in which the nitrogen and part of the conjugated chain usually form part of a heterocyclic system, such as imidazole, pyridine, pyrrole, quinoline and thiazole. http://purl.obolibrary.org/obo/CHEBI_38088 sultone http://purl.obolibrary.org/obo/CHEBI_35701 ester An intramolecular cyclic ester of a hydroxy sulfonic acid, analogous to lactone. http://purl.obolibrary.org/obo/CHEBI_38094 arenesulfonate ester http://purl.obolibrary.org/obo/CHEBI_83347 organosulfonic ester An organosulfonic ester resulting from the formal condensation of an arenesulfonic acid with the hydroxy group of an alcohol, enol, phenol or heteroarenol. http://purl.obolibrary.org/obo/CHEBI_33273 polyatomic anion http://purl.obolibrary.org/obo/CHEBI_36358 polyatomic ion An anion consisting of more than one atom. http://purl.obolibrary.org/obo/CHEBI_33359 rhodium atom http://purl.obolibrary.org/obo/CHEBI_33358 cobalt group element atom A cobalt group element atom of atomic number 45. http://purl.obolibrary.org/obo/CHEBI_33579 main group molecular entity http://purl.obolibrary.org/obo/CHEBI_23367 molecular entity A molecular entity containing one or more atoms from any of groups 1, 2, 13, 14, 15, 16, 17, and 18 of the periodic table. http://purl.obolibrary.org/obo/CHEBI_33595 cyclic compound http://purl.obolibrary.org/obo/CHEBI_25367 molecule Any molecule that consists of a series of atoms joined together to form a ring. http://purl.obolibrary.org/obo/CHEBI_33674 s-block molecular entity http://purl.obolibrary.org/obo/CHEBI_33579 main group molecular entity An s-block molecular entity is a molecular entity containing one or more atoms of an s-block element. http://purl.obolibrary.org/obo/CHEBI_33692 hydrides http://purl.obolibrary.org/obo/CHEBI_37577 heteroatomic molecular entity Hydrides are chemical compounds of hydrogen with other chemical elements. http://purl.obolibrary.org/obo/CHEBI_36339 baryon http://purl.obolibrary.org/obo/CHEBI_36343 composite particle Baryon is a fermion that does experience the strong force (strong interaction). The term is derived from the Greek betaalpharhoupsilonsigma (heavy). http://purl.obolibrary.org/obo/CHEBI_36342 subatomic particle http://purl.obolibrary.org/obo/BFO_0000040 material entity A particle smaller than an atom. http://purl.obolibrary.org/obo/CHEBI_36347 nuclear particle http://purl.obolibrary.org/obo/CHEBI_36342 subatomic particle A nucleus or any of its constituents in any of their energy states. http://purl.obolibrary.org/obo/CHEBI_39203 dibenzopyran http://purl.obolibrary.org/obo/CHEBI_38104 oxacycle Any organic heteropolycyclic compound based on a skeleton consisting of a pyran ring fused with two benzene rings. http://purl.obolibrary.org/obo/CHEBI_472552 5-bromo-2'-deoxyuridine http://purl.obolibrary.org/obo/CHEBI_19255 pyrimidine 2'-deoxyribonucleoside A pyrimidine 2'-deoxyribonucleoside compound having 5-bromouracil as the nucleobase. http://purl.obolibrary.org/obo/CHEBI_59051 diethyl pyrocarbonate http://purl.obolibrary.org/obo/CHEBI_36631 acyclic carboxylic anhydride The diethyl ester of dicarbonic acid. http://purl.obolibrary.org/obo/CHEBI_52673 Alexa Fluor 555 http://purl.obolibrary.org/obo/CHEBI_38835 xanthenes A fluorescent dye of absorption wavelength 555 nm and emission wavelength 565 nm, derived from a 3,6-diaminoxanthene-4,5-disulfate. http://purl.obolibrary.org/obo/CHEBI_67208 double-stranded RNA http://purl.obolibrary.org/obo/CHEBI_33697 ribonucleic acid A ribonucleic acid with two complementary strands, similar to the DNA found in all cells. http://purl.obolibrary.org/obo/GO_0005215 transporter activity http://purl.obolibrary.org/obo/GO_0003674 molecular_function Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells. http://purl.obolibrary.org/obo/GO_0005216 ion channel activity http://purl.obolibrary.org/obo/GO_0022838 substrate-specific channel activity Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size). http://purl.obolibrary.org/obo/GO_0005575 cellular_component http://purl.obolibrary.org/obo/BFO_0000040 material entity The part of a cell, extracellular environment or virus in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together. http://purl.obolibrary.org/obo/GO_0005610 laminin-5 complex http://purl.obolibrary.org/obo/GO_0043256 laminin complex A laminin complex composed of alpha3, beta3 and gamma2 polypeptide chains. http://purl.obolibrary.org/obo/GO_0005658 alpha DNA polymerase:primase complex http://purl.obolibrary.org/obo/GO_0055029 nuclear DNA-directed RNA polymerase complex A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis. http://purl.obolibrary.org/obo/GO_0005662 DNA replication factor A complex http://purl.obolibrary.org/obo/GO_0044454 nuclear chromosome part A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa. http://purl.obolibrary.org/obo/GO_0005663 DNA replication factor C complex http://purl.obolibrary.org/obo/GO_0044427 chromosomal part A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides. http://purl.obolibrary.org/obo/GO_0005667 transcription factor complex http://purl.obolibrary.org/obo/GO_0044424 intracellular part A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. http://purl.obolibrary.org/obo/GO_0005669 transcription factor TFIID complex http://purl.obolibrary.org/obo/GO_0044451 nucleoplasm part A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters. http://purl.obolibrary.org/obo/GO_0005674 transcription factor TFIIF complex http://purl.obolibrary.org/obo/GO_0044451 nucleoplasm part A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation. http://purl.obolibrary.org/obo/GO_0005680 anaphase-promoting complex http://purl.obolibrary.org/obo/GO_0000152 nuclear ubiquitin ligase complex A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. http://purl.obolibrary.org/obo/GO_0005736 DNA-directed RNA polymerase I complex http://purl.obolibrary.org/obo/GO_0055029 nuclear DNA-directed RNA polymerase complex RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template. http://purl.obolibrary.org/obo/GO_0005751 mitochondrial respiratory chain complex IV http://purl.obolibrary.org/obo/GO_0098800 inner mitochondrial membrane protein complex A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). http://purl.obolibrary.org/obo/GO_0005787 signal peptidase complex http://purl.obolibrary.org/obo/GO_1905368 peptidase complex A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space. http://purl.obolibrary.org/obo/GO_0005834 heterotrimeric G-protein complex http://purl.obolibrary.org/obo/GO_0098797 plasma membrane protein complex Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein. http://purl.obolibrary.org/obo/GO_0005845 mRNA cap binding complex http://purl.obolibrary.org/obo/GO_0044424 intracellular part Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA. http://purl.obolibrary.org/obo/GO_0005848 mRNA cleavage stimulating factor complex http://purl.obolibrary.org/obo/GO_0005849 mRNA cleavage factor complex A protein complex required for mRNA cleavage but not for poly(A) addition. http://purl.obolibrary.org/obo/GO_0005849 mRNA cleavage factor complex http://purl.obolibrary.org/obo/GO_0044451 nucleoplasm part Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules. http://purl.obolibrary.org/obo/GO_0005850 eukaryotic translation initiation factor 2 complex http://purl.obolibrary.org/obo/GO_0044444 cytoplasmic part Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA. http://purl.obolibrary.org/obo/GO_0005871 kinesin complex http://purl.obolibrary.org/obo/GO_0005875 microtubule associated complex Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work. http://purl.obolibrary.org/obo/GO_0005872 minus-end kinesin complex http://purl.obolibrary.org/obo/GO_0005871 kinesin complex Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the minus end of a microtubule. http://purl.obolibrary.org/obo/GO_0005873 plus-end kinesin complex http://purl.obolibrary.org/obo/GO_0005871 kinesin complex Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the plus end of a microtubule. http://purl.obolibrary.org/obo/GO_0005875 microtubule associated complex http://purl.obolibrary.org/obo/GO_0044430 cytoskeletal part Any multimeric complex connected to a microtubule. http://purl.obolibrary.org/obo/GO_0005892 acetylcholine-gated channel complex http://purl.obolibrary.org/obo/GO_0098802 plasma membrane receptor complex A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding. http://purl.obolibrary.org/obo/GO_0005922 connexin complex http://purl.obolibrary.org/obo/GO_0098797 plasma membrane protein complex An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction. http://purl.obolibrary.org/obo/GO_0005942 phosphatidylinositol 3-kinase complex http://purl.obolibrary.org/obo/GO_0061695 transferase complex, transferring phosphorus-containing groups A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too. http://purl.obolibrary.org/obo/GO_0005945 6-phosphofructokinase complex http://purl.obolibrary.org/obo/GO_0061695 transferase complex, transferring phosphorus-containing groups A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known. http://purl.obolibrary.org/obo/GO_0005953 CAAX-protein geranylgeranyltransferase complex http://purl.obolibrary.org/obo/GO_1990234 transferase complex A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane. http://purl.obolibrary.org/obo/GO_0005956 protein kinase CK2 complex http://purl.obolibrary.org/obo/GO_0044424 intracellular part A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein. http://purl.obolibrary.org/obo/GO_0005962 mitochondrial isocitrate dehydrogenase complex (NAD+) http://purl.obolibrary.org/obo/GO_0045242 isocitrate dehydrogenase complex (NAD+) Mitochondrial complex that possesses isocitrate dehydrogenase (NAD+) activity. http://purl.obolibrary.org/obo/GO_0005964 phosphorylase kinase complex http://purl.obolibrary.org/obo/GO_1902554 serine/threonine protein kinase complex An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a. http://purl.obolibrary.org/obo/GO_0005965 protein farnesyltransferase complex http://purl.obolibrary.org/obo/GO_1990234 transferase complex A protein complex that possesses protein farnesyltransferase activity. http://purl.obolibrary.org/obo/GO_0005971 ribonucleoside-diphosphate reductase complex http://purl.obolibrary.org/obo/GO_1990204 oxidoreductase complex An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor. http://purl.obolibrary.org/obo/GO_0005975 carbohydrate metabolic process http://purl.obolibrary.org/obo/GO_0071704 organic substance metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. http://purl.obolibrary.org/obo/GO_0005996 monosaccharide metabolic process http://purl.obolibrary.org/obo/GO_0044723 single-organism carbohydrate metabolic process The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. http://purl.obolibrary.org/obo/GO_0006006 glucose metabolic process http://purl.obolibrary.org/obo/GO_0019318 hexose metabolic process The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. http://purl.obolibrary.org/obo/GO_0006139 nucleobase-containing compound metabolic process http://purl.obolibrary.org/obo/GO_1901360 organic cyclic compound metabolic process Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids. http://purl.obolibrary.org/obo/GO_0006304 DNA modification http://purl.obolibrary.org/obo/GO_0006259 DNA metabolic process The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties. http://purl.obolibrary.org/obo/GO_0006305 DNA alkylation http://purl.obolibrary.org/obo/GO_0006304 DNA modification The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis. http://purl.obolibrary.org/obo/GO_0006306 DNA methylation http://purl.obolibrary.org/obo/GO_0043414 macromolecule methylation The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. http://purl.obolibrary.org/obo/GO_0006338 chromatin remodeling http://purl.obolibrary.org/obo/GO_0006325 chromatin organization Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation. http://purl.obolibrary.org/obo/GO_0006461 protein complex assembly http://purl.obolibrary.org/obo/GO_0071822 protein complex subunit organization The aggregation, arrangement and bonding together of a set of components to form a protein complex. http://purl.obolibrary.org/obo/GO_0006725 cellular aromatic compound metabolic process http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells. http://purl.obolibrary.org/obo/GO_0006807 nitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_0008152 metabolic process The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen, including (but not limited to) nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium. http://purl.obolibrary.org/obo/GO_0006810 transport http://purl.obolibrary.org/obo/GO_0051234 establishment of localization The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein. http://purl.obolibrary.org/obo/GO_0006811 ion transport http://purl.obolibrary.org/obo/GO_0006810 transport The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. http://purl.obolibrary.org/obo/GO_0006812 cation transport http://purl.obolibrary.org/obo/GO_0006811 ion transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. http://purl.obolibrary.org/obo/GO_0006887 exocytosis http://purl.obolibrary.org/obo/GO_0032940 secretion by cell A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell. http://purl.obolibrary.org/obo/GO_0006897 endocytosis http://purl.obolibrary.org/obo/GO_0016192 vesicle-mediated transport A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. http://purl.obolibrary.org/obo/GO_0006928 movement of cell or subcellular component http://purl.obolibrary.org/obo/GO_0044763 single-organism cellular process The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore. http://purl.obolibrary.org/obo/GO_0006996 organelle organization http://purl.obolibrary.org/obo/GO_0016043 cellular component organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. http://purl.obolibrary.org/obo/GO_0007015 actin filament organization http://purl.obolibrary.org/obo/GO_0097435 supramolecular fiber organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking. http://purl.obolibrary.org/obo/GO_0007596 blood coagulation http://purl.obolibrary.org/obo/GO_0050817 coagulation The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. http://purl.obolibrary.org/obo/GO_0007599 hemostasis http://purl.obolibrary.org/obo/GO_0050878 regulation of body fluid levels The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part. http://purl.obolibrary.org/obo/GO_0008024 cyclin/CDK positive transcription elongation factor complex http://purl.obolibrary.org/obo/GO_0008023 transcription elongation factor complex A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit. http://purl.obolibrary.org/obo/GO_0008152 metabolic process http://purl.obolibrary.org/obo/GO_0008150 biological_process The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. http://purl.obolibrary.org/obo/GO_0008154 actin polymerization or depolymerization http://purl.obolibrary.org/obo/GO_0007015 actin filament organization Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament. http://purl.obolibrary.org/obo/GO_0008290 F-actin capping protein complex http://purl.obolibrary.org/obo/GO_0044430 cytoskeletal part A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments. http://purl.obolibrary.org/obo/GO_0009566 fertilization http://purl.obolibrary.org/obo/GO_0044702 single organism reproductive process The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy). http://purl.obolibrary.org/obo/GO_0015075 ion transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0022891 substrate-specific transmembrane transporter activity Enables the transfer of an ion from one side of a membrane to the other. http://purl.obolibrary.org/obo/GO_0016020 membrane http://purl.obolibrary.org/obo/GO_0005575 cellular_component A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. http://purl.obolibrary.org/obo/GO_0016043 cellular component organization http://purl.obolibrary.org/obo/GO_0071840 cellular component organization or biogenesis A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component. http://purl.obolibrary.org/obo/GO_0016192 vesicle-mediated transport http://purl.obolibrary.org/obo/GO_0006810 transport A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane. http://purl.obolibrary.org/obo/GO_0016569 covalent chromatin modification http://purl.obolibrary.org/obo/GO_0006325 chromatin organization The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups. http://purl.obolibrary.org/obo/GO_0019219 regulation of nucleobase-containing compound metabolic process http://purl.obolibrary.org/obo/GO_0051171 regulation of nitrogen compound metabolic process Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids. http://purl.obolibrary.org/obo/GO_0019318 hexose metabolic process http://purl.obolibrary.org/obo/GO_0005996 monosaccharide metabolic process The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule. http://purl.obolibrary.org/obo/GO_0019538 protein metabolic process http://purl.obolibrary.org/obo/GO_1901564 organonitrogen compound metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general. Includes protein modification. http://purl.obolibrary.org/obo/GO_0019908 nuclear cyclin-dependent protein kinase holoenzyme complex http://purl.obolibrary.org/obo/GO_0044428 nuclear part Cyclin-dependent protein kinase (CDK) complex found in the nucleus. http://purl.obolibrary.org/obo/GO_0022838 substrate-specific channel activity http://purl.obolibrary.org/obo/GO_0015267 channel activity Enables the energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules. http://purl.obolibrary.org/obo/GO_0022857 transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0005215 transporter activity Enables the transfer of a substance from one side of a membrane to the other. http://purl.obolibrary.org/obo/GO_0022891 substrate-specific transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0022892 substrate-specific transporter activity Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other. http://purl.obolibrary.org/obo/GO_0022892 substrate-specific transporter activity http://purl.obolibrary.org/obo/GO_0005215 transporter activity Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells. http://purl.obolibrary.org/obo/GO_0030062 mitochondrial tricarboxylic acid cycle enzyme complex http://purl.obolibrary.org/obo/GO_0045239 tricarboxylic acid cycle enzyme complex Any of the heteromeric enzymes, located in the mitochondrion, that act in the tricarboxylic acid (TCA) cycle. http://purl.obolibrary.org/obo/GO_0031461 cullin-RING ubiquitin ligase complex http://purl.obolibrary.org/obo/GO_0000151 ubiquitin ligase complex Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity. http://purl.obolibrary.org/obo/GO_0032259 methylation http://purl.obolibrary.org/obo/GO_0008152 metabolic process The process in which a methyl group is covalently attached to a molecule. http://purl.obolibrary.org/obo/GO_0032806 carboxy-terminal domain protein kinase complex http://purl.obolibrary.org/obo/GO_1902554 serine/threonine protein kinase complex A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5. http://purl.obolibrary.org/obo/GO_0033036 macromolecule localization http://purl.obolibrary.org/obo/GO_0051179 localization Any process in which a macromolecule is transported to, or maintained in, a specific location. http://purl.obolibrary.org/obo/GO_0033218 amide binding http://purl.obolibrary.org/obo/GO_0005488 binding Interacting selectively and non-covalently with an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group. http://purl.obolibrary.org/obo/GO_0034518 RNA cap binding complex http://purl.obolibrary.org/obo/GO_0032991 macromolecular complex Any protein complex that binds to a specialized RNA cap structure at any time in the lifetime of the RNA. http://purl.obolibrary.org/obo/GO_0034641 cellular nitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds, as carried out by individual cells. http://purl.obolibrary.org/obo/GO_0034645 cellular macromolecule biosynthetic process http://purl.obolibrary.org/obo/GO_0009059 macromolecule biosynthetic process The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, carried out by individual cells. http://purl.obolibrary.org/obo/GO_0034702 ion channel complex http://purl.obolibrary.org/obo/GO_1902495 transmembrane transporter complex A protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient. http://purl.obolibrary.org/obo/GO_0036211 protein modification process http://purl.obolibrary.org/obo/GO_0043412 macromolecule modification The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). http://purl.obolibrary.org/obo/GO_0040029 regulation of gene expression, epigenetic http://purl.obolibrary.org/obo/GO_0010468 regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence. http://purl.obolibrary.org/obo/GO_0042555 MCM complex http://purl.obolibrary.org/obo/GO_0043234 protein complex A hexameric protein complex required for the initiation and regulation of DNA replication. http://purl.obolibrary.org/obo/GO_0043170 macromolecule metabolic process http://purl.obolibrary.org/obo/GO_0071704 organic substance metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. http://purl.obolibrary.org/obo/GO_0043231 intracellular membrane-bounded organelle http://purl.obolibrary.org/obo/GO_0043229 intracellular organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. http://purl.obolibrary.org/obo/GO_0043256 laminin complex http://purl.obolibrary.org/obo/GO_0044420 extracellular matrix component A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes. http://purl.obolibrary.org/obo/GO_0043412 macromolecule modification http://purl.obolibrary.org/obo/GO_0043170 macromolecule metabolic process The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties. http://purl.obolibrary.org/obo/GO_0044238 primary metabolic process http://purl.obolibrary.org/obo/GO_0008152 metabolic process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. http://purl.obolibrary.org/obo/GO_0044249 cellular biosynthetic process http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells. http://purl.obolibrary.org/obo/GO_0044260 cellular macromolecule metabolic process http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells. http://purl.obolibrary.org/obo/GO_0044267 cellular protein metabolic process http://purl.obolibrary.org/obo/GO_0044260 cellular macromolecule metabolic process The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification. http://purl.obolibrary.org/obo/GO_0044281 small molecule metabolic process http://purl.obolibrary.org/obo/GO_0044710 single-organism metabolic process The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule. http://purl.obolibrary.org/obo/GO_0044421 extracellular region part http://purl.obolibrary.org/obo/GO_0005575 cellular_component Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite. http://purl.obolibrary.org/obo/GO_0044455 mitochondrial membrane part http://purl.obolibrary.org/obo/GO_0044429 mitochondrial part Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope. http://purl.obolibrary.org/obo/GO_0044464 cell part http://purl.obolibrary.org/obo/GO_0005575 cellular_component Any constituent part of a cell, the basic structural and functional unit of all organisms. http://purl.obolibrary.org/obo/GO_0044710 single-organism metabolic process http://purl.obolibrary.org/obo/GO_0044699 single-organism process A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves a single organism. http://purl.obolibrary.org/obo/GO_0044723 single-organism carbohydrate metabolic process http://purl.obolibrary.org/obo/GO_0044710 single-organism metabolic process The chemical reactions and pathways involving carbohydrates, occurring within a single organism. http://purl.obolibrary.org/obo/GO_0044728 DNA methylation or demethylation http://purl.obolibrary.org/obo/GO_0006304 DNA modification The process of adding or removing a methyl group from one or more nucleotides within an DNA molecule. http://purl.obolibrary.org/obo/GO_0044765 single-organism transport http://purl.obolibrary.org/obo/GO_1902578 single-organism localization The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving a single organism. http://purl.obolibrary.org/obo/GO_0045242 isocitrate dehydrogenase complex (NAD+) http://purl.obolibrary.org/obo/GO_0045239 tricarboxylic acid cycle enzyme complex Complex that possesses isocitrate dehydrogenase (NAD+) activity. http://purl.obolibrary.org/obo/GO_0045277 respiratory chain complex IV http://purl.obolibrary.org/obo/GO_0070069 cytochrome complex A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). http://purl.obolibrary.org/obo/GO_0050817 coagulation http://purl.obolibrary.org/obo/GO_0044707 single-multicellular organism process The process in which a fluid solution, or part of it, changes into a solid or semisolid mass. http://purl.obolibrary.org/obo/GO_0050896 response to stimulus http://purl.obolibrary.org/obo/GO_0008150 biological_process Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism. http://purl.obolibrary.org/obo/GO_0051234 establishment of localization http://purl.obolibrary.org/obo/GO_0051179 localization Any process that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. http://purl.obolibrary.org/obo/GO_0051716 cellular response to stimulus http://purl.obolibrary.org/obo/GO_0009987 cellular process Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell. http://purl.obolibrary.org/obo/GO_0065003 macromolecular complex assembly http://purl.obolibrary.org/obo/GO_0043933 macromolecular complex subunit organization The aggregation, arrangement and bonding together of a set of macromolecules to form a complex. http://purl.obolibrary.org/obo/GO_0071702 organic substance transport http://purl.obolibrary.org/obo/GO_0006810 transport The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon. http://purl.obolibrary.org/obo/GO_0071704 organic substance metabolic process http://purl.obolibrary.org/obo/GO_0008152 metabolic process The chemical reactions and pathways involving an organic substance, any molecular entity containing carbon. http://purl.obolibrary.org/obo/GO_0071705 nitrogen compound transport http://purl.obolibrary.org/obo/GO_0006810 transport The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. http://purl.obolibrary.org/obo/GO_0071822 protein complex subunit organization http://purl.obolibrary.org/obo/GO_0043933 macromolecular complex subunit organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein complex. http://purl.obolibrary.org/obo/GO_0080090 regulation of primary metabolic process http://purl.obolibrary.org/obo/GO_0019222 regulation of metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism involving those compounds formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. http://purl.obolibrary.org/obo/GO_0090304 nucleic acid metabolic process http://purl.obolibrary.org/obo/GO_0043170 macromolecule metabolic process Any cellular metabolic process involving nucleic acids. http://purl.obolibrary.org/obo/GO_0090568 nuclear transcriptional repressor complex http://purl.obolibrary.org/obo/GO_0017053 transcriptional repressor complex A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription. http://purl.obolibrary.org/obo/GO_0090575 RNA polymerase II transcription factor complex http://purl.obolibrary.org/obo/GO_0044798 nuclear transcription factor complex A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase II. http://purl.obolibrary.org/obo/GO_0097435 supramolecular fiber organization http://purl.obolibrary.org/obo/GO_0044763 single-organism cellular process A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure. http://purl.obolibrary.org/obo/GO_0098798 mitochondrial protein complex http://purl.obolibrary.org/obo/GO_0044429 mitochondrial part A protein complex that is part of a mitochondrion. http://purl.obolibrary.org/obo/GO_0098802 plasma membrane receptor complex http://purl.obolibrary.org/obo/GO_0044459 plasma membrane part Any protein complex that is part of the plasma membrane and which functions as a receptor. http://purl.obolibrary.org/obo/GO_0098805 whole membrane http://purl.obolibrary.org/obo/GO_0016020 membrane Any lipid bilayer that completely encloses some structure, and all the proteins embedded in it or attached to it. Examples include the plasma membrane and most organelle membranes. http://purl.obolibrary.org/obo/GO_0101031 chaperone complex http://purl.obolibrary.org/obo/GO_0043234 protein complex A protein complex required for the non-covalent folding or unfolding, maturation, stabilization or assembly or disassembly of macromolecular structures. Usually active during or immediately after completion of translation. Many chaperone complexes contain heat shock proteins. http://purl.obolibrary.org/obo/GO_1901576 organic substance biosynthetic process http://purl.obolibrary.org/obo/GO_0009058 biosynthetic process The chemical reactions and pathways resulting in the formation of an organic substance, any molecular entity containing carbon. http://purl.obolibrary.org/obo/GO_1902911 protein kinase complex http://purl.obolibrary.org/obo/GO_0061695 transferase complex, transferring phosphorus-containing groups A protein complex which is capable of protein kinase activity. http://purl.obolibrary.org/obo/GO_1905360 GTPase complex http://purl.obolibrary.org/obo/GO_1902494 catalytic complex A protein complex which is capable of GTPase activity. http://purl.obolibrary.org/obo/GO_0046696 lipopolysaccharide receptor complex http://purl.obolibrary.org/obo/GO_0044425 membrane part A multiprotein complex that consists of at least three proteins, CD14, TLR4, and MD-2, each of which is glycosylated and which functions as a lipopolysaccharide (LPS) receptor that primes the innate immune response against bacterial pathogens. http://purl.obolibrary.org/obo/GO_0065007 biological regulation http://purl.obolibrary.org/obo/GO_0008150 biological_process Any process that modulates a measurable attribute of any biological process, quality or function. http://purl.obolibrary.org/obo/UBERON_0000055 vessel http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure A tubular structure that contains, conveys body fluid, such as blood or lymph. http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome. http://purl.obolibrary.org/obo/UBERON_0000062 organ http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure Anatomical structure that performs a specific function or group of functions [WP]. http://purl.obolibrary.org/obo/UBERON_0000105 life cycle stage http://purl.obolibrary.org/obo/BFO_0000015 process A spatiotemporal region encompassing some part of the life cycle of an organism. http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity http://purl.obolibrary.org/obo/BFO_0000040 material entity Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. http://purl.obolibrary.org/obo/UBERON_0001981 blood vessel http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure A vessel through which blood circulates in the body. http://purl.obolibrary.org/obo/UBERON_0002530 gland http://purl.obolibrary.org/obo/UBERON_0000062 organ an organ that functions as a secretory or excretory organ http://purl.obolibrary.org/obo/UBERON_0003498 heart blood vessel http://purl.obolibrary.org/obo/UBERON_0005985 coronary vessel A blood vessel that is part of a heart [Automatically generated definition]. http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure An anatomical structure that develops (entirely or partially) from the mesoderm. http://purl.obolibrary.org/obo/UBERON_0005177 trunk region element http://purl.obolibrary.org/obo/UBERON_0000062 organ An organ or element that part of the trunk region. The trunk region can be further subdividied into thoracic (including chest and thoracic cavity) and abdominal (including abdomen and pelbis) regions. http://purl.obolibrary.org/obo/UBERON_0005985 coronary vessel http://purl.obolibrary.org/obo/UBERON_0004120 mesoderm-derived structure Any of the arteries or veins that supply blood to the heart or return blood from the heart muscles to the circulation http://purl.obolibrary.org/obo/UBERON_0006925 digestive gland http://purl.obolibrary.org/obo/UBERON_0002530 gland A gland, such as the liver or pancreas, that secretes into the alimentary canal substances necessary for digestion. http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure An anatomical structure that has more than one cell as a part. http://purl.obolibrary.org/obo/CHEBI_15377 water http://purl.obolibrary.org/obo/CHEBI_33692 hydrides An oxygen hydride consisting of an oxygen atom that is covalently bonded to two hydrogen atoms. http://purl.obolibrary.org/obo/CHEBI_15378 hydron http://purl.obolibrary.org/obo/CHEBI_36347 nuclear particle The general name for the hydrogen nucleus, to be used without regard to the hydrogen nuclear mass (either for hydrogen in its natural abundance or where it is not desired to distinguish between the isotopes). http://purl.obolibrary.org/obo/CHEBI_37141 organobromine compound http://purl.obolibrary.org/obo/CHEBI_36684 organohalogen compound A compound containing at least one carbon-bromine bond. http://purl.obolibrary.org/obo/CHEBI_18254 ribonucleoside http://purl.obolibrary.org/obo/CHEBI_47017 tetrahydrofuranol Any nucleoside where the sugar component is D-ribose. http://purl.obolibrary.org/obo/CHEBI_35348 3beta-sterol http://purl.obolibrary.org/obo/CHEBI_36834 3-hydroxy steroid A sterol that has a hydroxy group at position 3 with beta- configuration. http://purl.obolibrary.org/obo/CHEBI_27081 transition element atom http://purl.obolibrary.org/obo/CHEBI_33521 metal atom An element whose atom has an incomplete d sub-shell, or which can give rise to cations with an incomplete d sub-shell. http://purl.obolibrary.org/obo/CHEBI_33672 heterobicyclic compound http://purl.obolibrary.org/obo/CHEBI_33595 cyclic compound A bicyclic compound in which at least one of the rings contains at least one skeletal heteroatom. http://purl.obolibrary.org/obo/CHEBI_35873 carboxylic anhydride http://purl.obolibrary.org/obo/CHEBI_36606 acid anhydride Anhydrides derived from carboxylic acids. http://purl.obolibrary.org/obo/CHEBI_36343 composite particle http://purl.obolibrary.org/obo/CHEBI_36342 subatomic particle A subatomic particle known to have substructure (i.e. consisting of smaller particles). http://purl.obolibrary.org/obo/CHEBI_36606 acid anhydride http://purl.obolibrary.org/obo/CHEBI_50860 organic molecular entity Compounds consisting of two acyl groups bonded to the same oxygen atom acyl-O-acyl. http://purl.obolibrary.org/obo/CHEBI_53526 tritiated thymidine http://purl.obolibrary.org/obo/CHEBI_19255 pyrimidine 2'-deoxyribonucleoside Thymidine linked to the radioisotope tritium. Used to label DNA in the study of cellular and viral DNA synthesis. http://purl.obolibrary.org/obo/XAO_1000000 Xenopus developmental stage http://purl.obolibrary.org/obo/UBERON_0000105 life cycle stage A temporal interval that defines Xenopus life from unfertilized egg to adult and death stages. http://purl.obolibrary.org/obo/GO_0000015 phosphopyruvate hydratase complex http://purl.obolibrary.org/obo/GO_1902494 catalytic complex A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. http://purl.obolibrary.org/obo/GO_0000127 transcription factor TFIIIC complex http://purl.obolibrary.org/obo/GO_0090576 RNA polymerase III transcription factor complex A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions. http://purl.obolibrary.org/obo/GO_0000151 ubiquitin ligase complex http://purl.obolibrary.org/obo/GO_1990234 transferase complex A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex. http://purl.obolibrary.org/obo/GO_0000152 nuclear ubiquitin ligase complex http://purl.obolibrary.org/obo/GO_0044428 nuclear part A ubiquitin ligase complex found in the nucleus. http://purl.obolibrary.org/obo/GO_0000307 cyclin-dependent protein kinase holoenzyme complex http://purl.obolibrary.org/obo/GO_1902554 serine/threonine protein kinase complex Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. http://purl.obolibrary.org/obo/GO_0000428 DNA-directed RNA polymerase complex http://purl.obolibrary.org/obo/GO_0030880 RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity. http://purl.obolibrary.org/obo/GO_0000502 proteasome complex http://purl.obolibrary.org/obo/GO_1905369 endopeptidase complex A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core. http://purl.obolibrary.org/obo/GO_0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex http://purl.obolibrary.org/obo/GO_1990234 transferase complex An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast. http://purl.obolibrary.org/obo/GO_0000782 telomere cap complex http://purl.obolibrary.org/obo/GO_0044427 chromosomal part A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome. http://purl.obolibrary.org/obo/GO_0000783 nuclear telomere cap complex http://purl.obolibrary.org/obo/GO_0044454 nuclear chromosome part A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome. http://purl.obolibrary.org/obo/GO_0000975 regulatory region DNA binding http://purl.obolibrary.org/obo/GO_0003677 DNA binding Interacting selectively and non-covalently with a DNA region that regulates a DNA-based process. Such processes include transcription, DNA replication, and DNA repair. http://purl.obolibrary.org/obo/GO_0001047 core promoter binding http://purl.obolibrary.org/obo/GO_0044212 transcription regulatory region DNA binding Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. http://purl.obolibrary.org/obo/GO_0001067 regulatory region nucleic acid binding http://purl.obolibrary.org/obo/GO_0003676 nucleic acid binding Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair. http://purl.obolibrary.org/obo/GO_0001775 cell activation http://purl.obolibrary.org/obo/GO_0044763 single-organism cellular process A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand. http://purl.obolibrary.org/obo/GO_0001788 antibody-dependent cellular cytotoxicity http://purl.obolibrary.org/obo/GO_0044699 single-organism process Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells. http://purl.obolibrary.org/obo/GO_0001794 type IIa hypersensitivity http://purl.obolibrary.org/obo/GO_0002445 type II hypersensitivity An inflammatory response resulting in cell death mediated by activation of the classical complement pathway or induction of effector cell phagocytosis or cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell. http://purl.obolibrary.org/obo/GO_0001806 type IV hypersensitivity http://purl.obolibrary.org/obo/GO_0002524 hypersensitivity An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation. http://purl.obolibrary.org/obo/GO_0001816 cytokine production http://purl.obolibrary.org/obo/GO_0044707 single-multicellular organism process The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0001821 histamine secretion http://purl.obolibrary.org/obo/GO_0051608 histamine transport The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems. http://purl.obolibrary.org/obo/GO_0001906 cell killing http://purl.obolibrary.org/obo/GO_0008150 biological_process Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions. http://purl.obolibrary.org/obo/GO_0001909 leukocyte mediated cytotoxicity http://purl.obolibrary.org/obo/GO_0001906 cell killing The directed killing of a target cell by a leukocyte. http://purl.obolibrary.org/obo/GO_0001913 T cell mediated cytotoxicity http://purl.obolibrary.org/obo/GO_0044699 single-organism process The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. http://purl.obolibrary.org/obo/GO_0002169 3-methylcrotonyl-CoA carboxylase complex, mitochondrial http://purl.obolibrary.org/obo/GO_1905202 methylcrotonoyl-CoA carboxylase complex A mitochondrial protein complex which is capable of 3-methylcrotonyl-CoA carboxylase activity. In mammals, at least, consists as a dodecamer of 6 alpha and 6 beta subunits. MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation. MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA. http://purl.obolibrary.org/obo/GO_0002178 palmitoyltransferase complex http://purl.obolibrary.org/obo/GO_1990234 transferase complex A protein complex with palmitoyltransferase activity. http://purl.obolibrary.org/obo/GO_0002179 homodimeric serine palmitoyltransferase complex http://purl.obolibrary.org/obo/GO_0017059 serine C-palmitoyltransferase complex A homodimeric complex which transfers a palmitoyl group onto serine, forming 3-dehydro-D-sphinganine. http://purl.obolibrary.org/obo/GO_0002180 5-lipoxygenase complex http://purl.obolibrary.org/obo/GO_1990204 oxidoreductase complex An nuclear membrane protein complex having arachidonate 5-lipoxygenase activity. http://purl.obolibrary.org/obo/GO_0002185 creatine kinase complex http://purl.obolibrary.org/obo/GO_0061695 transferase complex, transferring phosphorus-containing groups A protein complex having creatine kinase activity. http://purl.obolibrary.org/obo/GO_0002186 cytosolic creatine kinase complex http://purl.obolibrary.org/obo/GO_0044445 cytosolic part A dimeric protein complex having creatine kinase activity. http://purl.obolibrary.org/obo/GO_0002197 xanthine dehydrogenase complex http://purl.obolibrary.org/obo/GO_1990204 oxidoreductase complex A homodimeric protein complex having xanthine dehydrogenase activity. http://purl.obolibrary.org/obo/GO_0002199 zona pellucida receptor complex http://purl.obolibrary.org/obo/GO_0043234 protein complex A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction. http://purl.obolibrary.org/obo/GO_0002250 adaptive immune response http://purl.obolibrary.org/obo/GO_0006955 immune response An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory). http://purl.obolibrary.org/obo/GO_0002252 immune effector process http://purl.obolibrary.org/obo/GO_0002376 immune system process Any process of the immune system that can potentially contribute to an immune response. http://purl.obolibrary.org/obo/GO_0002263 cell activation involved in immune response http://purl.obolibrary.org/obo/GO_0002252 immune effector process A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response. http://purl.obolibrary.org/obo/GO_0002285 lymphocyte activation involved in immune response http://purl.obolibrary.org/obo/GO_0046649 lymphocyte activation A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. http://purl.obolibrary.org/obo/GO_0002286 T cell activation involved in immune response http://purl.obolibrary.org/obo/GO_0042110 T cell activation The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response. http://purl.obolibrary.org/obo/GO_0002366 leukocyte activation involved in immune response http://purl.obolibrary.org/obo/GO_0045321 leukocyte activation A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response. http://purl.obolibrary.org/obo/GO_0002367 cytokine production involved in immune response http://purl.obolibrary.org/obo/GO_0002440 production of molecular mediator of immune response The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0002376 immune system process http://purl.obolibrary.org/obo/GO_0008150 biological_process Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. http://purl.obolibrary.org/obo/GO_0002390 platelet activating factor production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The synthesis or release of platelet activating factor following a stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0002437 inflammatory response to antigenic stimulus http://purl.obolibrary.org/obo/GO_0006955 immune response An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes. http://purl.obolibrary.org/obo/GO_0002438 acute inflammatory response to antigenic stimulus http://purl.obolibrary.org/obo/GO_0002526 acute inflammatory response An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response. http://purl.obolibrary.org/obo/GO_0002440 production of molecular mediator of immune response http://purl.obolibrary.org/obo/GO_0002376 immune system process The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0002441 histamine secretion involved in inflammatory response http://purl.obolibrary.org/obo/GO_0046879 hormone secretion The regulated release of histamine by a cell as part of an inflammatory response. http://purl.obolibrary.org/obo/GO_0002443 leukocyte mediated immunity http://purl.obolibrary.org/obo/GO_0002252 immune effector process Any process involved in the carrying out of an immune response by a leukocyte. http://purl.obolibrary.org/obo/GO_0002444 myeloid leukocyte mediated immunity http://purl.obolibrary.org/obo/GO_0002443 leukocyte mediated immunity Any process involved in the carrying out of an immune response by a myeloid leukocyte. http://purl.obolibrary.org/obo/GO_0002445 type II hypersensitivity http://purl.obolibrary.org/obo/GO_0016064 immunoglobulin mediated immune response An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors. http://purl.obolibrary.org/obo/GO_0002449 lymphocyte mediated immunity http://purl.obolibrary.org/obo/GO_0002443 leukocyte mediated immunity Any process involved in the carrying out of an immune response by a lymphocyte. http://purl.obolibrary.org/obo/GO_0002456 T cell mediated immunity http://purl.obolibrary.org/obo/GO_0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains Any process involved in the carrying out of an immune response by a T cell. http://purl.obolibrary.org/obo/GO_0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains http://purl.obolibrary.org/obo/GO_0002250 adaptive immune response An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus. http://purl.obolibrary.org/obo/GO_0002507 tolerance induction http://purl.obolibrary.org/obo/GO_0002376 immune system process A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it. http://purl.obolibrary.org/obo/GO_0002514 B cell tolerance induction http://purl.obolibrary.org/obo/GO_0002507 tolerance induction A process involving any mechanism for tolerance induction in B cells. http://purl.obolibrary.org/obo/GO_0002517 T cell tolerance induction http://purl.obolibrary.org/obo/GO_0002507 tolerance induction A process involving any mechanism for tolerance induction in T cells. http://purl.obolibrary.org/obo/GO_0002524 hypersensitivity http://purl.obolibrary.org/obo/GO_0002438 acute inflammatory response to antigenic stimulus An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system. http://purl.obolibrary.org/obo/GO_0002526 acute inflammatory response http://purl.obolibrary.org/obo/GO_0006954 inflammatory response Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response. http://purl.obolibrary.org/obo/GO_0002532 production of molecular mediator involved in inflammatory response http://purl.obolibrary.org/obo/GO_0044707 single-multicellular organism process The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0002534 cytokine production involved in inflammatory response http://purl.obolibrary.org/obo/GO_0002532 production of molecular mediator involved in inflammatory response The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0002682 regulation of immune system process http://purl.obolibrary.org/obo/GO_0050789 regulation of biological process Any process that modulates the frequency, rate, or extent of an immune system process. http://purl.obolibrary.org/obo/GO_0002684 positive regulation of immune system process http://purl.obolibrary.org/obo/GO_0048518 positive regulation of biological process Any process that activates or increases the frequency, rate, or extent of an immune system process. http://purl.obolibrary.org/obo/GO_0002697 regulation of immune effector process http://purl.obolibrary.org/obo/GO_0002682 regulation of immune system process Any process that modulates the frequency, rate, or extent of an immune effector process. http://purl.obolibrary.org/obo/GO_0002699 positive regulation of immune effector process http://purl.obolibrary.org/obo/GO_0002697 regulation of immune effector process Any process that activates or increases the frequency, rate, or extent of an immune effector process. http://purl.obolibrary.org/obo/GO_0002703 regulation of leukocyte mediated immunity http://purl.obolibrary.org/obo/GO_0002697 regulation of immune effector process Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity. http://purl.obolibrary.org/obo/GO_0002705 positive regulation of leukocyte mediated immunity http://purl.obolibrary.org/obo/GO_0002703 regulation of leukocyte mediated immunity Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity. http://purl.obolibrary.org/obo/GO_0002706 regulation of lymphocyte mediated immunity http://purl.obolibrary.org/obo/GO_0002703 regulation of leukocyte mediated immunity Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity. http://purl.obolibrary.org/obo/GO_0002708 positive regulation of lymphocyte mediated immunity http://purl.obolibrary.org/obo/GO_0002706 regulation of lymphocyte mediated immunity Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity. http://purl.obolibrary.org/obo/GO_0002709 regulation of T cell mediated immunity http://purl.obolibrary.org/obo/GO_0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains Any process that modulates the frequency, rate, or extent of T cell mediated immunity. http://purl.obolibrary.org/obo/GO_0002711 positive regulation of T cell mediated immunity http://purl.obolibrary.org/obo/GO_0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity. http://purl.obolibrary.org/obo/GO_0002712 regulation of B cell mediated immunity http://purl.obolibrary.org/obo/GO_0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains Any process that modulates the frequency, rate, or extent of B cell mediated immunity. http://purl.obolibrary.org/obo/GO_0002714 positive regulation of B cell mediated immunity http://purl.obolibrary.org/obo/GO_0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity. http://purl.obolibrary.org/obo/GO_0002819 regulation of adaptive immune response http://purl.obolibrary.org/obo/GO_0050776 regulation of immune response Any process that modulates the frequency, rate, or extent of an adaptive immune response. http://purl.obolibrary.org/obo/GO_0002821 positive regulation of adaptive immune response http://purl.obolibrary.org/obo/GO_0050778 positive regulation of immune response Any process that activates or increases the frequency, rate, or extent of an adaptive immune response. http://purl.obolibrary.org/obo/GO_0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains http://purl.obolibrary.org/obo/GO_0002819 regulation of adaptive immune response Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. http://purl.obolibrary.org/obo/GO_0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains http://purl.obolibrary.org/obo/GO_0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata. http://purl.obolibrary.org/obo/GO_0002947 tumor necrosis factor receptor superfamily complex http://purl.obolibrary.org/obo/GO_0043235 receptor complex A receptor complex that contains one or more members of the tumor necrosis factor (TNF) receptor superfamily. http://purl.obolibrary.org/obo/GO_0003674 molecular_function http://purl.obolibrary.org/obo/BFO_0000034 function Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions. http://purl.obolibrary.org/obo/GO_0003676 nucleic acid binding http://purl.obolibrary.org/obo/GO_1901363 heterocyclic compound binding Interacting selectively and non-covalently with any nucleic acid. http://purl.obolibrary.org/obo/GO_0003677 DNA binding http://purl.obolibrary.org/obo/GO_0003676 nucleic acid binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). http://purl.obolibrary.org/obo/GO_0003823 antigen binding http://purl.obolibrary.org/obo/GO_0005488 binding Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen. http://purl.obolibrary.org/obo/GO_0003824 catalytic activity http://purl.obolibrary.org/obo/GO_0003674 molecular_function Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. http://purl.obolibrary.org/obo/GO_0003964 RNA-directed DNA polymerase activity http://purl.obolibrary.org/obo/GO_0034061 DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time. http://purl.obolibrary.org/obo/GO_0005488 binding http://purl.obolibrary.org/obo/GO_0003674 molecular_function The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. http://purl.obolibrary.org/obo/GO_0005515 protein binding http://purl.obolibrary.org/obo/GO_0005488 binding Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules). http://purl.obolibrary.org/obo/GO_0005694 chromosome http://purl.obolibrary.org/obo/GO_0043232 intracellular non-membrane-bounded organelle A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. http://purl.obolibrary.org/obo/GO_0005739 mitochondrion http://purl.obolibrary.org/obo/GO_0044444 cytoplasmic part A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. http://purl.obolibrary.org/obo/GO_0005832 chaperonin-containing T-complex http://purl.obolibrary.org/obo/GO_0044445 cytosolic part A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor. http://purl.obolibrary.org/obo/GO_0005886 plasma membrane http://purl.obolibrary.org/obo/GO_0044464 cell part The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. http://purl.obolibrary.org/obo/GO_0006259 DNA metabolic process http://purl.obolibrary.org/obo/GO_0090304 nucleic acid metabolic process Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. http://purl.obolibrary.org/obo/GO_0006260 DNA replication http://purl.obolibrary.org/obo/GO_0006259 DNA metabolic process The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. http://purl.obolibrary.org/obo/GO_0006325 chromatin organization http://purl.obolibrary.org/obo/GO_0016043 cellular component organization Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin. http://purl.obolibrary.org/obo/GO_0006464 cellular protein modification process http://purl.obolibrary.org/obo/GO_0044267 cellular protein metabolic process The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). http://purl.obolibrary.org/obo/GO_0006909 phagocytosis http://purl.obolibrary.org/obo/GO_0044765 single-organism transport An endocytosis process that results in the engulfment of external particulate material by phagocytes. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles. http://purl.obolibrary.org/obo/GO_0006950 response to stress http://purl.obolibrary.org/obo/GO_0050896 response to stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). http://purl.obolibrary.org/obo/GO_0006952 defense response http://purl.obolibrary.org/obo/GO_0006950 response to stress Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. http://purl.obolibrary.org/obo/GO_0006954 inflammatory response http://purl.obolibrary.org/obo/GO_0006952 defense response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. http://purl.obolibrary.org/obo/GO_0006955 immune response http://purl.obolibrary.org/obo/GO_0002376 immune system process Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. http://purl.obolibrary.org/obo/GO_0006974 cellular response to DNA damage stimulus http://purl.obolibrary.org/obo/GO_0033554 cellular response to stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism. http://purl.obolibrary.org/obo/GO_0007049 cell cycle http://purl.obolibrary.org/obo/GO_0044763 single-organism cellular process The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division. http://purl.obolibrary.org/obo/GO_0008023 transcription elongation factor complex http://purl.obolibrary.org/obo/GO_0044451 nucleoplasm part Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation. http://purl.obolibrary.org/obo/GO_0008150 biological_process http://purl.obolibrary.org/obo/BFO_0000015 process Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end. http://purl.obolibrary.org/obo/GO_0008278 cohesin complex http://purl.obolibrary.org/obo/GO_0044427 chromosomal part A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3). http://purl.obolibrary.org/obo/GO_0008283 cell proliferation http://purl.obolibrary.org/obo/GO_0044699 single-organism process The multiplication or reproduction of cells, resulting in the expansion of a cell population. http://purl.obolibrary.org/obo/GO_0009058 biosynthetic process http://purl.obolibrary.org/obo/GO_0008152 metabolic process The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. http://purl.obolibrary.org/obo/GO_0009059 macromolecule biosynthetic process http://purl.obolibrary.org/obo/GO_1901576 organic substance biosynthetic process The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. http://purl.obolibrary.org/obo/GO_0009914 hormone transport http://purl.obolibrary.org/obo/GO_0010817 regulation of hormone levels The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. http://purl.obolibrary.org/obo/GO_0009987 cellular process http://purl.obolibrary.org/obo/GO_0008150 biological_process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. http://purl.obolibrary.org/obo/GO_0010008 endosome membrane http://purl.obolibrary.org/obo/GO_0044440 endosomal part The lipid bilayer surrounding an endosome. http://purl.obolibrary.org/obo/GO_0010467 gene expression http://purl.obolibrary.org/obo/GO_0043170 macromolecule metabolic process The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. http://purl.obolibrary.org/obo/GO_0010468 regulation of gene expression http://purl.obolibrary.org/obo/GO_0060255 regulation of macromolecule metabolic process Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form. http://purl.obolibrary.org/obo/GO_0010817 regulation of hormone levels http://purl.obolibrary.org/obo/GO_0065008 regulation of biological quality Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. http://purl.obolibrary.org/obo/GO_0015696 ammonium transport http://purl.obolibrary.org/obo/GO_0071705 nitrogen compound transport The directed movement of ammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals. http://purl.obolibrary.org/obo/GO_0016064 immunoglobulin mediated immune response http://purl.obolibrary.org/obo/GO_0019724 B cell mediated immunity An immune response mediated by immunoglobulins, whether cell-bound or in solution. http://purl.obolibrary.org/obo/GO_0016570 histone modification http://purl.obolibrary.org/obo/GO_0006464 cellular protein modification process The covalent alteration of one or more amino acid residues within a histone protein. http://purl.obolibrary.org/obo/GO_0016592 mediator complex http://purl.obolibrary.org/obo/GO_0044451 nucleoplasm part A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. http://purl.obolibrary.org/obo/GO_0016740 transferase activity http://purl.obolibrary.org/obo/GO_0003824 catalytic activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. http://purl.obolibrary.org/obo/GO_0016779 nucleotidyltransferase activity http://purl.obolibrary.org/obo/GO_0016772 transferase activity, transferring phosphorus-containing groups Catalysis of the transfer of a nucleotidyl group to a reactant. http://purl.obolibrary.org/obo/GO_0017059 serine C-palmitoyltransferase complex http://purl.obolibrary.org/obo/GO_0031211 endoplasmic reticulum palmitoyltransferase complex An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine. http://purl.obolibrary.org/obo/GO_0019724 B cell mediated immunity http://purl.obolibrary.org/obo/GO_0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells. http://purl.obolibrary.org/obo/GO_0019882 antigen processing and presentation http://purl.obolibrary.org/obo/GO_0002376 immune system process The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. http://purl.obolibrary.org/obo/GO_0022414 reproductive process http://purl.obolibrary.org/obo/GO_0008150 biological_process A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents. http://purl.obolibrary.org/obo/GO_0022607 cellular component assembly http://purl.obolibrary.org/obo/GO_0016043 cellular component organization The aggregation, arrangement and bonding together of a cellular component. http://purl.obolibrary.org/obo/GO_0030097 hemopoiesis http://purl.obolibrary.org/obo/GO_0048534 hematopoietic or lymphoid organ development The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates. http://purl.obolibrary.org/obo/GO_0030880 RNA polymerase complex http://purl.obolibrary.org/obo/GO_0061695 transferase complex, transferring phosphorus-containing groups Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits. http://purl.obolibrary.org/obo/GO_0031323 regulation of cellular metabolic process http://purl.obolibrary.org/obo/GO_0019222 regulation of metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances. http://purl.obolibrary.org/obo/GO_0031501 mannosyltransferase complex http://purl.obolibrary.org/obo/GO_1990234 transferase complex A complex that posseses mannosyltransferase activity. http://purl.obolibrary.org/obo/GO_0032501 multicellular organismal process http://purl.obolibrary.org/obo/GO_0008150 biological_process Any biological process, occurring at the level of a multicellular organism, pertinent to its function. http://purl.obolibrary.org/obo/GO_0032502 developmental process http://purl.obolibrary.org/obo/GO_0008150 biological_process A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition. http://purl.obolibrary.org/obo/GO_0032940 secretion by cell http://purl.obolibrary.org/obo/GO_0046903 secretion The controlled release of a substance by a cell. http://purl.obolibrary.org/obo/GO_0032991 macromolecular complex http://purl.obolibrary.org/obo/GO_0005575 cellular_component A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. http://purl.obolibrary.org/obo/GO_0032993 protein-DNA complex http://purl.obolibrary.org/obo/GO_0032991 macromolecular complex A macromolecular complex containing both protein and DNA molecules. http://purl.obolibrary.org/obo/GO_0033554 cellular response to stress http://purl.obolibrary.org/obo/GO_0006950 response to stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation). http://purl.obolibrary.org/obo/GO_0034061 DNA polymerase activity http://purl.obolibrary.org/obo/GO_0016779 nucleotidyltransferase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a nucleic acid template and a 3'hydroxyl group. http://purl.obolibrary.org/obo/GO_0034622 cellular macromolecular complex assembly http://purl.obolibrary.org/obo/GO_0065003 macromolecular complex assembly The aggregation, arrangement and bonding together of a set of macromolecules to form a complex, carried out at the cellular level. http://purl.obolibrary.org/obo/GO_0042098 T cell proliferation http://purl.obolibrary.org/obo/GO_0046651 lymphocyte proliferation The expansion of a T cell population by cell division. Follows T cell activation. http://purl.obolibrary.org/obo/GO_0042110 T cell activation http://purl.obolibrary.org/obo/GO_0046649 lymphocyte activation The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. http://purl.obolibrary.org/obo/GO_0042277 peptide binding http://purl.obolibrary.org/obo/GO_0033218 amide binding Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds. http://purl.obolibrary.org/obo/GO_0042575 DNA polymerase complex http://purl.obolibrary.org/obo/GO_0061695 transferase complex, transferring phosphorus-containing groups A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA. http://purl.obolibrary.org/obo/GO_0043226 organelle http://purl.obolibrary.org/obo/GO_0005575 cellular_component Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane. http://purl.obolibrary.org/obo/GO_0043232 intracellular non-membrane-bounded organelle http://purl.obolibrary.org/obo/GO_0043228 non-membrane-bounded organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes. http://purl.obolibrary.org/obo/GO_0043234 protein complex http://purl.obolibrary.org/obo/GO_0032991 macromolecular complex A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical. http://purl.obolibrary.org/obo/GO_0043235 receptor complex http://purl.obolibrary.org/obo/GO_0032991 macromolecular complex Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. http://purl.obolibrary.org/obo/GO_0043299 leukocyte degranulation http://purl.obolibrary.org/obo/GO_0045055 regulated exocytosis The regulated exocytosis of secretory granules by a leukocyte. http://purl.obolibrary.org/obo/GO_0043414 macromolecule methylation http://purl.obolibrary.org/obo/GO_0044260 cellular macromolecule metabolic process The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule. http://purl.obolibrary.org/obo/GO_0043623 cellular protein complex assembly http://purl.obolibrary.org/obo/GO_0034622 cellular macromolecular complex assembly The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell. http://purl.obolibrary.org/obo/GO_0043933 macromolecular complex subunit organization http://purl.obolibrary.org/obo/GO_0016043 cellular component organization Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a macromolecular complex. http://purl.obolibrary.org/obo/GO_0044212 transcription regulatory region DNA binding http://purl.obolibrary.org/obo/GO_0000975 regulatory region DNA binding Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors. http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process http://purl.obolibrary.org/obo/GO_0009987 cellular process The chemical reactions and pathways by which individual cells transform chemical substances. http://purl.obolibrary.org/obo/GO_0044420 extracellular matrix component http://purl.obolibrary.org/obo/GO_0044421 extracellular region part Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants). http://purl.obolibrary.org/obo/GO_0044422 organelle part http://purl.obolibrary.org/obo/GO_0005575 cellular_component Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane. http://purl.obolibrary.org/obo/GO_0044424 intracellular part http://purl.obolibrary.org/obo/GO_0044464 cell part Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm. http://purl.obolibrary.org/obo/GO_0044425 membrane part http://purl.obolibrary.org/obo/GO_0005575 cellular_component Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. http://purl.obolibrary.org/obo/GO_0044427 chromosomal part http://purl.obolibrary.org/obo/GO_0044446 intracellular organelle part Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information. http://purl.obolibrary.org/obo/GO_0044428 nuclear part http://purl.obolibrary.org/obo/GO_0044446 intracellular organelle part Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. http://purl.obolibrary.org/obo/GO_0044429 mitochondrial part http://purl.obolibrary.org/obo/GO_0044446 intracellular organelle part Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. http://purl.obolibrary.org/obo/GO_0044430 cytoskeletal part http://purl.obolibrary.org/obo/GO_0044446 intracellular organelle part Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice. http://purl.obolibrary.org/obo/GO_0044431 Golgi apparatus part http://purl.obolibrary.org/obo/GO_0044446 intracellular organelle part Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. http://purl.obolibrary.org/obo/GO_0044432 endoplasmic reticulum part http://purl.obolibrary.org/obo/GO_0044446 intracellular organelle part Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. http://purl.obolibrary.org/obo/GO_0044433 cytoplasmic vesicle part http://purl.obolibrary.org/obo/GO_0044446 intracellular organelle part Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell. http://purl.obolibrary.org/obo/GO_0044444 cytoplasmic part http://purl.obolibrary.org/obo/GO_0044424 intracellular part Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. http://purl.obolibrary.org/obo/GO_0044445 cytosolic part http://purl.obolibrary.org/obo/GO_0044444 cytoplasmic part Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components. http://purl.obolibrary.org/obo/GO_0044451 nucleoplasm part http://purl.obolibrary.org/obo/GO_0044428 nuclear part Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus. http://purl.obolibrary.org/obo/GO_0044452 nucleolar part http://purl.obolibrary.org/obo/GO_0044428 nuclear part Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. http://purl.obolibrary.org/obo/GO_0044453 nuclear membrane part http://purl.obolibrary.org/obo/GO_0044428 nuclear part Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells. http://purl.obolibrary.org/obo/GO_0044454 nuclear chromosome part http://purl.obolibrary.org/obo/GO_0044428 nuclear part Any constituent part of a nuclear chromosome, a chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. http://purl.obolibrary.org/obo/GO_0044459 plasma membrane part http://purl.obolibrary.org/obo/GO_0044425 membrane part Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. http://purl.obolibrary.org/obo/GO_0044699 single-organism process http://purl.obolibrary.org/obo/GO_0008150 biological_process A biological process that involves only one organism. http://purl.obolibrary.org/obo/GO_0044702 single organism reproductive process http://purl.obolibrary.org/obo/GO_0044699 single-organism process A biological process that directly contributes to the process of producing new individuals, involving a single organism. http://purl.obolibrary.org/obo/GO_0044707 single-multicellular organism process http://purl.obolibrary.org/obo/GO_0044699 single-organism process A biological process occurring within a single, multicellular organism. http://purl.obolibrary.org/obo/GO_0044763 single-organism cellular process http://purl.obolibrary.org/obo/GO_0044699 single-organism process Any process that is carried out at the cellular level, occurring within a single organism. http://purl.obolibrary.org/obo/GO_0044767 single-organism developmental process http://purl.obolibrary.org/obo/GO_0044699 single-organism process A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, involving only one organism. http://purl.obolibrary.org/obo/GO_0044798 nuclear transcription factor complex http://purl.obolibrary.org/obo/GO_0044428 nuclear part A protein complex, located in the nucleus, that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription. http://purl.obolibrary.org/obo/GO_0045055 regulated exocytosis http://purl.obolibrary.org/obo/GO_0006887 exocytosis A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand. http://purl.obolibrary.org/obo/GO_0045321 leukocyte activation http://purl.obolibrary.org/obo/GO_0002376 immune system process A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor. http://purl.obolibrary.org/obo/GO_0046483 heterocycle metabolic process http://purl.obolibrary.org/obo/GO_0044237 cellular metabolic process The chemical reactions and pathways involving heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings). http://purl.obolibrary.org/obo/GO_0046649 lymphocyte activation http://purl.obolibrary.org/obo/GO_0045321 leukocyte activation A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor. http://purl.obolibrary.org/obo/GO_0046651 lymphocyte proliferation http://purl.obolibrary.org/obo/GO_0032943 mononuclear cell proliferation The expansion of a lymphocyte population by cell division. http://purl.obolibrary.org/obo/GO_0046879 hormone secretion http://purl.obolibrary.org/obo/GO_0023061 signal release The regulated release of hormones, substances with a specific regulatory effect on a particular organ or group of cells. http://purl.obolibrary.org/obo/GO_0046903 secretion http://purl.obolibrary.org/obo/GO_0044765 single-organism transport The controlled release of a substance by a cell or a tissue. http://purl.obolibrary.org/obo/GO_0048513 animal organ development http://purl.obolibrary.org/obo/GO_0048856 anatomical structure development Development of a tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions. http://purl.obolibrary.org/obo/GO_0048518 positive regulation of biological process http://purl.obolibrary.org/obo/GO_0050789 regulation of biological process Any process that activates or increases the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. http://purl.obolibrary.org/obo/GO_0048583 regulation of response to stimulus http://purl.obolibrary.org/obo/GO_0050789 regulation of biological process Any process that modulates the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. http://purl.obolibrary.org/obo/GO_0048584 positive regulation of response to stimulus http://purl.obolibrary.org/obo/GO_0048583 regulation of response to stimulus Any process that activates, maintains or increases the rate of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. http://purl.obolibrary.org/obo/GO_0048856 anatomical structure development http://purl.obolibrary.org/obo/GO_0032502 developmental process The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome. http://purl.obolibrary.org/obo/GO_0048869 cellular developmental process http://purl.obolibrary.org/obo/GO_0044767 single-organism developmental process A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition. http://purl.obolibrary.org/obo/GO_0048870 cell motility http://purl.obolibrary.org/obo/GO_0040011 locomotion Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another. http://purl.obolibrary.org/obo/GO_0050776 regulation of immune response http://purl.obolibrary.org/obo/GO_0048583 regulation of response to stimulus Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. http://purl.obolibrary.org/obo/GO_0050778 positive regulation of immune response http://purl.obolibrary.org/obo/GO_0050776 regulation of immune response Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus. http://purl.obolibrary.org/obo/GO_0050789 regulation of biological process http://purl.obolibrary.org/obo/GO_0065007 biological regulation Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule. http://purl.obolibrary.org/obo/GO_0050794 regulation of cellular process http://purl.obolibrary.org/obo/GO_0050789 regulation of biological process Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level. http://purl.obolibrary.org/obo/GO_0050878 regulation of body fluid levels http://purl.obolibrary.org/obo/GO_0065008 regulation of biological quality Any process that modulates the levels of body fluids. http://purl.obolibrary.org/obo/GO_0051052 regulation of DNA metabolic process http://purl.obolibrary.org/obo/GO_0060255 regulation of macromolecule metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA. http://purl.obolibrary.org/obo/GO_0051258 protein polymerization http://purl.obolibrary.org/obo/GO_0043623 cellular protein complex assembly The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein. http://purl.obolibrary.org/obo/GO_0051276 chromosome organization http://purl.obolibrary.org/obo/GO_0006996 organelle organization A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome. http://purl.obolibrary.org/obo/GO_0051608 histamine transport http://purl.obolibrary.org/obo/GO_0045117 azole transport The directed movement of histamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. http://purl.obolibrary.org/obo/GO_0055029 nuclear DNA-directed RNA polymerase complex http://purl.obolibrary.org/obo/GO_0044428 nuclear part A protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity. http://purl.obolibrary.org/obo/GO_0060255 regulation of macromolecule metabolic process http://purl.obolibrary.org/obo/GO_0019222 regulation of metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. http://purl.obolibrary.org/obo/GO_0061695 transferase complex, transferring phosphorus-containing groups http://purl.obolibrary.org/obo/GO_1990234 transferase complex A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). http://purl.obolibrary.org/obo/GO_0065008 regulation of biological quality http://purl.obolibrary.org/obo/GO_0065007 biological regulation Any process that modulates a qualitative or quantitative trait of a biological quality. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc. http://purl.obolibrary.org/obo/GO_0070661 leukocyte proliferation http://purl.obolibrary.org/obo/GO_0008283 cell proliferation The expansion of a leukocyte population by cell division. http://purl.obolibrary.org/obo/GO_0090576 RNA polymerase III transcription factor complex http://purl.obolibrary.org/obo/GO_0044798 nuclear transcription factor complex A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase III. http://purl.obolibrary.org/obo/GO_0097159 organic cyclic compound binding http://purl.obolibrary.org/obo/GO_0005488 binding Interacting selectively and non-covalently with an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure. http://purl.obolibrary.org/obo/GO_0098588 bounding membrane of organelle http://purl.obolibrary.org/obo/GO_0031090 organelle membrane The lipid bilayer that forms the outer-most layer of an organelle. http://purl.obolibrary.org/obo/GO_0098796 membrane protein complex http://purl.obolibrary.org/obo/GO_0044425 membrane part Any protein complex that is part of a membrane. http://purl.obolibrary.org/obo/GO_0098797 plasma membrane protein complex http://purl.obolibrary.org/obo/GO_0098796 membrane protein complex Any protein complex that is part of the plasma membrane. http://purl.obolibrary.org/obo/GO_0098800 inner mitochondrial membrane protein complex http://purl.obolibrary.org/obo/GO_0098796 membrane protein complex Any protein complex that is part of the inner mitochondrial membrane. http://purl.obolibrary.org/obo/GO_1901360 organic cyclic compound metabolic process http://purl.obolibrary.org/obo/GO_0071704 organic substance metabolic process The chemical reactions and pathways involving organic cyclic compound. http://purl.obolibrary.org/obo/GO_1901363 heterocyclic compound binding http://purl.obolibrary.org/obo/GO_0005488 binding Interacting selectively and non-covalently with heterocyclic compound. http://purl.obolibrary.org/obo/GO_1901564 organonitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_0071704 organic substance metabolic process The chemical reactions and pathways involving organonitrogen compound. http://purl.obolibrary.org/obo/GO_1902494 catalytic complex http://purl.obolibrary.org/obo/GO_0032991 macromolecular complex A protein complex which is capable of catalytic activity. http://purl.obolibrary.org/obo/GO_1902554 serine/threonine protein kinase complex http://purl.obolibrary.org/obo/GO_1902911 protein kinase complex A protein complex which is capable of protein serine/threonine kinase activity. http://purl.obolibrary.org/obo/GO_1905202 methylcrotonoyl-CoA carboxylase complex http://purl.obolibrary.org/obo/GO_1902494 catalytic complex A protein complex which is capable of methylcrotonoyl-CoA carboxylase activity. http://purl.obolibrary.org/obo/GO_1905368 peptidase complex http://purl.obolibrary.org/obo/GO_1902494 catalytic complex A protein complex which is capable of peptidase activity. http://purl.obolibrary.org/obo/GO_1905369 endopeptidase complex http://purl.obolibrary.org/obo/GO_1905368 peptidase complex A protein complex which is capable of endopeptidase activity. http://purl.obolibrary.org/obo/GO_1990204 oxidoreductase complex http://purl.obolibrary.org/obo/GO_1902494 catalytic complex Any protein complex that possesses oxidoreductase activity. http://purl.obolibrary.org/obo/GO_1990234 transferase complex http://purl.obolibrary.org/obo/GO_1902494 catalytic complex A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). http://purl.obolibrary.org/obo/GO_0019005 SCF ubiquitin ligase complex http://purl.obolibrary.org/obo/GO_0031461 cullin-RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1). http://purl.obolibrary.org/obo/GO_0019185 snRNA-activating protein complex http://purl.obolibrary.org/obo/GO_0044798 nuclear transcription factor complex A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters. http://purl.obolibrary.org/obo/GO_0019814 immunoglobulin complex http://purl.obolibrary.org/obo/GO_0043234 protein complex A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph. http://purl.obolibrary.org/obo/GO_0019815 B cell receptor complex http://purl.obolibrary.org/obo/GO_0019814 immunoglobulin complex An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins. http://purl.obolibrary.org/obo/GO_0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex http://purl.obolibrary.org/obo/GO_0032806 carboxy-terminal domain protein kinase complex A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH. http://purl.obolibrary.org/obo/GO_0023061 signal release http://purl.obolibrary.org/obo/GO_0032940 secretion by cell The process in which a signal is secreted or discharged into the extracellular medium from a cellular source. http://purl.obolibrary.org/obo/GO_0030041 actin filament polymerization http://purl.obolibrary.org/obo/GO_0051258 protein polymerization Assembly of actin filaments by the addition of actin monomers to a filament. http://purl.obolibrary.org/obo/GO_0030117 membrane coat http://purl.obolibrary.org/obo/GO_0098796 membrane protein complex Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules. http://purl.obolibrary.org/obo/GO_0030120 vesicle coat http://purl.obolibrary.org/obo/GO_0030117 membrane coat A membrane coat found on a coated vesicle. http://purl.obolibrary.org/obo/GO_0031264 death-inducing signaling complex http://purl.obolibrary.org/obo/GO_0098797 plasma membrane protein complex A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10. http://purl.obolibrary.org/obo/GO_0031932 TORC2 complex http://purl.obolibrary.org/obo/GO_0038201 TOR complex A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p. http://purl.obolibrary.org/obo/GO_0032144 4-aminobutyrate transaminase complex http://purl.obolibrary.org/obo/GO_1990234 transferase complex A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity. http://purl.obolibrary.org/obo/GO_0032299 ribonuclease H2 complex http://purl.obolibrary.org/obo/GO_0044424 intracellular part A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p. http://purl.obolibrary.org/obo/GO_0032601 connective tissue growth factor production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of connective tissue growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032602 chemokine production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032604 granulocyte macrophage colony-stimulating factor production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of granulocyte macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032605 hepatocyte growth factor production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of hepatocyte growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032606 type I interferon production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families. http://purl.obolibrary.org/obo/GO_0032608 interferon-beta production http://purl.obolibrary.org/obo/GO_0032606 type I interferon production The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032609 interferon-gamma production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon. http://purl.obolibrary.org/obo/GO_0032610 interleukin-1 alpha production http://purl.obolibrary.org/obo/GO_0032612 interleukin-1 production The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032611 interleukin-1 beta production http://purl.obolibrary.org/obo/GO_0032612 interleukin-1 production The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032612 interleukin-1 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032613 interleukin-10 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032614 interleukin-11 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-11 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032615 interleukin-12 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032616 interleukin-13 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032617 interleukin-14 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-14 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032618 interleukin-15 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032619 interleukin-16 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-16 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032620 interleukin-17 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032621 interleukin-18 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032622 interleukin-19 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-19 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032623 interleukin-2 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032624 interleukin-20 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-20 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032625 interleukin-21 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032626 interleukin-22 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032627 interleukin-23 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-23 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032628 interleukin-24 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-24 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032629 interleukin-25 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-25 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032630 interleukin-26 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-26 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032631 interleukin-27 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-27 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032632 interleukin-3 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032633 interleukin-4 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032634 interleukin-5 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032635 interleukin-6 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032636 interleukin-7 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-7 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032637 interleukin-8 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032638 interleukin-9 production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032639 TRAIL production http://purl.obolibrary.org/obo/GO_0071706 tumor necrosis factor superfamily cytokine production The appearance of TRAIL due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032640 tumor necrosis factor production http://purl.obolibrary.org/obo/GO_0071706 tumor necrosis factor superfamily cytokine production The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032641 lymphotoxin A production http://purl.obolibrary.org/obo/GO_0071706 tumor necrosis factor superfamily cytokine production The appearance of lymphotoxin A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032905 transforming growth factor beta1 production http://purl.obolibrary.org/obo/GO_0071604 transforming growth factor beta production The appearance of transforming growth factor-beta1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032906 transforming growth factor beta2 production http://purl.obolibrary.org/obo/GO_0071604 transforming growth factor beta production The appearance of transforming growth factor-beta2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032907 transforming growth factor beta3 production http://purl.obolibrary.org/obo/GO_0071604 transforming growth factor beta production The appearance of transforming growth factor-beta3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0032943 mononuclear cell proliferation http://purl.obolibrary.org/obo/GO_0070661 leukocyte proliferation The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form. http://purl.obolibrary.org/obo/GO_0032996 Bcl3-Bcl10 complex http://purl.obolibrary.org/obo/GO_0044424 intracellular part A protein complex containing Bcl3 and Bcl10, which forms when Akt1 is activated by TNF-alpha to phosphorylate Bcl10; the Bcl3-Bcl10 complex is translocated to the nucleus. http://purl.obolibrary.org/obo/GO_0033185 dolichol-phosphate-mannose synthase complex http://purl.obolibrary.org/obo/GO_0031501 mannosyltransferase complex A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively. http://purl.obolibrary.org/obo/GO_0033597 mitotic checkpoint complex http://purl.obolibrary.org/obo/GO_0044428 nuclear part A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20. http://purl.obolibrary.org/obo/GO_0034708 methyltransferase complex http://purl.obolibrary.org/obo/GO_1990234 transferase complex A protein complex that possesses methyltransferase activity. http://purl.obolibrary.org/obo/GO_0038201 TOR complex http://purl.obolibrary.org/obo/GO_0044424 intracellular part A protein complex that contains at least TOR (target of rapamycin) in complex with other signaling components. Mediates the phosphorylation and activation of downstream signaling components including PKB (AKT) or S6K. http://purl.obolibrary.org/obo/GO_0040011 locomotion http://purl.obolibrary.org/obo/GO_0008150 biological_process Self-propelled movement of a cell or organism from one location to another. http://purl.obolibrary.org/obo/GO_0042611 MHC protein complex http://purl.obolibrary.org/obo/GO_0098797 plasma membrane protein complex A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen. http://purl.obolibrary.org/obo/GO_0043227 membrane-bounded organelle http://purl.obolibrary.org/obo/GO_0043226 organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. http://purl.obolibrary.org/obo/GO_0045239 tricarboxylic acid cycle enzyme complex http://purl.obolibrary.org/obo/GO_0044444 cytoplasmic part Any of the heteromeric enzymes that act in the TCA cycle. http://purl.obolibrary.org/obo/GO_0048534 hematopoietic or lymphoid organ development http://purl.obolibrary.org/obo/GO_0048513 animal organ development The process whose specific outcome is the progression of any organ involved in hematopoiesis (also known as hemopoiesis) or lymphoid cell activation over time, from its formation to the mature structure. Such development includes differentiation of resident cell types (stromal cells) and of migratory cell types dependent on the unique microenvironment afforded by the organ for their proper differentiation. http://purl.obolibrary.org/obo/GO_0051179 localization http://purl.obolibrary.org/obo/GO_0008150 biological_process Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported, tethered to or otherwise maintained in a specific location. In the case of substances, localization may also be achieved via selective degradation. http://purl.obolibrary.org/obo/GO_0071604 transforming growth factor beta production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of any member of the transforming growth factor-beta family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Transforming growth factor-beta family members include TGF-B1, TGF-B2, and TGF-B3. http://purl.obolibrary.org/obo/GO_0071706 tumor necrosis factor superfamily cytokine production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of any member of the TNF superfamily due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0080008 Cul4-RING E3 ubiquitin ligase complex http://purl.obolibrary.org/obo/GO_0031461 cullin-RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul4 family and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein. http://purl.obolibrary.org/obo/GO_1990351 transporter complex http://purl.obolibrary.org/obo/GO_0032991 macromolecular complex A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells. http://purl.obolibrary.org/obo/GO_0034343 type III interferon production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of type III interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon lambda is the only member of the type III interferon found so far. http://purl.obolibrary.org/obo/GO_0034688 integrin alphaM-beta2 complex http://purl.obolibrary.org/obo/GO_0008305 integrin complex An integrin complex that comprises one alphaM subunit and one beta2 subunit. http://purl.obolibrary.org/obo/GO_0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex http://purl.obolibrary.org/obo/GO_0098802 plasma membrane receptor complex A heterodimeric protein complex containing Toll-like receptor 1 (TLR1) and Toll-like receptor 2 (TLR2). http://purl.obolibrary.org/obo/GO_0035355 Toll-like receptor 2-Toll-like receptor 6 protein complex http://purl.obolibrary.org/obo/GO_0098802 plasma membrane receptor complex A heterodimeric protein complex containing Toll-like receptor 2 (TLR2) and Toll-like receptor 6 (TLR6). http://purl.obolibrary.org/obo/GO_0035393 chemokine (C-X-C motif) ligand 9 production http://purl.obolibrary.org/obo/GO_0032602 chemokine production The appearance of chemokine (C-X-C motif) ligand 9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0035397 helper T cell enhancement of adaptive immune response http://purl.obolibrary.org/obo/GO_0002824 positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains Positive regulation of an adaptive immune response mediated via cytokine production by helper T cell. http://purl.obolibrary.org/obo/GO_0035398 helper T cell enhancement of T cell mediated immune response http://purl.obolibrary.org/obo/GO_0035397 helper T cell enhancement of adaptive immune response Positive regulation of a T cell mediated immune response mediated via cytokine production by a helper T cell. http://purl.obolibrary.org/obo/GO_0035399 helper T cell enhancement of B cell mediated immune response http://purl.obolibrary.org/obo/GO_0035397 helper T cell enhancement of adaptive immune response Positive regulation of a B cell mediated immune response mediated via cytokine production by a helper T cell. http://purl.obolibrary.org/obo/GO_0035525 NF-kappaB p50/p65 complex http://purl.obolibrary.org/obo/GO_0071159 NF-kappaB complex A heterodimer of NF-kappa B p50 and p65 subunits. http://purl.obolibrary.org/obo/GO_0035746 granzyme A production http://purl.obolibrary.org/obo/GO_0002440 production of molecular mediator of immune response The appearance of granzyme A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0035944 perforin production http://purl.obolibrary.org/obo/GO_0002440 production of molecular mediator of immune response The appearance of a perforin protein due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0036262 granulysin production http://purl.obolibrary.org/obo/GO_0002440 production of molecular mediator of immune response The appearance of granulysin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0040030 regulation of molecular function, epigenetic http://purl.obolibrary.org/obo/GO_0065009 regulation of molecular function Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya. http://purl.obolibrary.org/obo/GO_0042101 T cell receptor complex http://purl.obolibrary.org/obo/GO_0098802 plasma membrane receptor complex A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains. http://purl.obolibrary.org/obo/GO_0042571 immunoglobulin complex, circulating http://purl.obolibrary.org/obo/GO_0019814 immunoglobulin complex An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component. http://purl.obolibrary.org/obo/GO_0042605 peptide antigen binding http://purl.obolibrary.org/obo/GO_0042277 peptide binding Interacting selectively and non-covalently with an antigen peptide. http://purl.obolibrary.org/obo/GO_0042765 GPI-anchor transamidase complex http://purl.obolibrary.org/obo/GO_1902494 catalytic complex An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor. http://purl.obolibrary.org/obo/GO_0043229 intracellular organelle http://purl.obolibrary.org/obo/GO_0044424 intracellular part Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane. http://purl.obolibrary.org/obo/GO_0043240 Fanconi anaemia nuclear complex http://purl.obolibrary.org/obo/GO_0044451 nucleoplasm part A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage. http://purl.obolibrary.org/obo/GO_0043316 cytotoxic T cell degranulation http://purl.obolibrary.org/obo/GO_0043299 leukocyte degranulation The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell. http://purl.obolibrary.org/obo/GO_0043514 interleukin-12 complex http://purl.obolibrary.org/obo/GO_0043234 protein complex A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space. http://purl.obolibrary.org/obo/GO_0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex http://purl.obolibrary.org/obo/GO_0061695 transferase complex, transferring phosphorus-containing groups A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis. http://purl.obolibrary.org/obo/GO_0043626 PCNA complex http://purl.obolibrary.org/obo/GO_0044796 DNA polymerase processivity factor complex A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation. http://purl.obolibrary.org/obo/GO_0044030 regulation of DNA methylation http://purl.obolibrary.org/obo/GO_0051052 regulation of DNA metabolic process Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine. http://purl.obolibrary.org/obo/GO_0044796 DNA polymerase processivity factor complex http://purl.obolibrary.org/obo/GO_0044424 intracellular part A protein complex which is capable of increasing the processivity of nucleotide polymerization by DNA polymerase as a part of DNA replication. http://purl.obolibrary.org/obo/GO_0044807 macrophage migration inhibitory factor production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of macrophage migration inhibitory factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0044808 Oncostatin M production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of Oncostatin M due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0044809 chemokine (C-C motif) ligand 17 production http://purl.obolibrary.org/obo/GO_0032602 chemokine production The appearance of chemokine (C-C motif) ligand 17 (CCL17) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0071159 NF-kappaB complex http://purl.obolibrary.org/obo/GO_0044424 intracellular part A protein complex that consists of a homo- or heterodimer of members of a family of structurally related proteins that contain a conserved N-terminal region called the Rel homology domain (RHD). In the nucleus, NF-kappaB complexes act as transcription factors. In unstimulated cells, NF-kappaB dimers are sequestered in the cytoplasm by IkappaB monomers; signals that induce NF-kappaB activity cause degradation of IkappaB, allowing NF-kappaB dimers to translocate to the nucleus and induce gene expression. http://purl.obolibrary.org/obo/GO_0098803 respiratory chain complex http://purl.obolibrary.org/obo/GO_0098796 membrane protein complex Any protein complex that is part of a respiratory chain http://purl.obolibrary.org/obo/GO_1902578 single-organism localization http://purl.obolibrary.org/obo/GO_0051179 localization A localization which involves only one organism. http://purl.obolibrary.org/obo/GO_0097071 interferon regulatory factor complex http://purl.obolibrary.org/obo/GO_0043234 protein complex A protein complex that consists of two interferon regulatory proteins (IRFs); may be homodimeric or heterodimeric. The activation of a latent closed conformation of IRF in the cytoplasm is triggered by phosphorylation of Ser/Thr residues in a C-terminal region. Phosphorylation stimulates the C-terminal autoinhibitory domain to attain a highly extended conformation triggering dimerization through extensive contacts to a second subunit. http://purl.obolibrary.org/obo/GO_0097073 interferon regulatory factor 5 complex http://purl.obolibrary.org/obo/GO_0097071 interferon regulatory factor complex An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 5. http://purl.obolibrary.org/obo/GO_0097087 interleukin-17A production http://purl.obolibrary.org/obo/GO_0032620 interleukin-17 production The appearance of interleukin-17A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0097088 interleukin-17F production http://purl.obolibrary.org/obo/GO_0032620 interleukin-17 production The appearance of interleukin-17F due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0097278 complement-dependent cytotoxicity http://purl.obolibrary.org/obo/GO_0044699 single-organism process Lysis of a cell resulting from triggering of the complement cascade. An example can be seen with complement activation and subsequent lysis of a bacterial cell as a result of the binding of IgM to the cell surface followed by the binding of complement proteins to that antibody. http://purl.obolibrary.org/obo/GO_0097280 histamine secretion mediated by immunoglobulin http://purl.obolibrary.org/obo/GO_0002441 histamine secretion involved in inflammatory response Histamine release triggered by the binding of an antigen to an immunoglobulin bound to the cell surface. http://purl.obolibrary.org/obo/GO_0097281 immune complex formation http://purl.obolibrary.org/obo/GO_0016064 immunoglobulin mediated immune response The process that gives rise to an immune complex. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution. Examples are the clumping of cells such as bacteria or red blood cells in the presence of an antibody, precipitation of a toxin after an antibody binds to it, and clumping of viral particles as a result of antibody binding to the virus. http://purl.obolibrary.org/obo/GO_0097282 immunoglobulin-mediated neutralization http://purl.obolibrary.org/obo/GO_0016064 immunoglobulin mediated immune response The inhibition of an antigen's biological effects by antibody binding to it. An example is neutralization of diphtheria toxin by preventing its entry into human cells via the binding of antibody specific for diphtheria toxin. http://purl.obolibrary.org/obo/GO_0097388 chemokine (C-C motif) ligand 19 production http://purl.obolibrary.org/obo/GO_0032602 chemokine production The appearance of chemokine (C-C motif) ligand 19 (CCL19) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0097389 chemokine (C-C motif) ligand 21 production http://purl.obolibrary.org/obo/GO_0032602 chemokine production The appearance of chemokine (C-C motif) ligand 21 (CCL21) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0097390 chemokine (C-X-C motif) ligand 12 production http://purl.obolibrary.org/obo/GO_0032602 chemokine production The appearance of chemokine (C-X-C motif) ligand 12 (CXCL12) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0097391 chemokine (C-X-C motif) ligand 13 production http://purl.obolibrary.org/obo/GO_0032602 chemokine production The appearance of chemokine (C-X-C motif) ligand 13 (CXCL13) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0097392 chemokine (C-X-C motif) ligand 16 production http://purl.obolibrary.org/obo/GO_0032602 chemokine production The appearance of chemokine (C-X-C motif) ligand 16 (CXCL16) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0097452 GAIT complex http://purl.obolibrary.org/obo/GO_0043234 protein complex A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP. http://purl.obolibrary.org/obo/GO_1990265 platelet-derived growth factor complex http://purl.obolibrary.org/obo/GO_0036454 growth factor complex A protein complex consisting of two chains of platelet-derived growth factor (PDGF) subunits. PDGF dimers bind to PDGF receptors in the plasma membrane and induce receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes. PDGFs are found in all vertebrates where at least 2 different chains (A and B) exist. In human (and other mammals), four types of PDGF chains (A, B, C, and D) are known which form five different dimers (AA, AB, BB, CC and DD). http://purl.obolibrary.org/obo/GO_0008228 opsonization http://purl.obolibrary.org/obo/GO_0002252 immune effector process The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody. http://purl.obolibrary.org/obo/GO_0008303 caspase complex http://purl.obolibrary.org/obo/GO_1905369 endopeptidase complex A protein complex that is located in the cytosol and contains one or more cysteine-type endopeptidases (also called caspases), which give the complex a peptidase activity with specificity for the hydrolysis of aspartyl bonds. These complexes may be involved e.g. in apoptotic or inflammation processes. http://purl.obolibrary.org/obo/GO_0008305 integrin complex http://purl.obolibrary.org/obo/GO_0098636 protein complex involved in cell adhesion A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands. http://purl.obolibrary.org/obo/GO_0008385 IkappaB kinase complex http://purl.obolibrary.org/obo/GO_1902554 serine/threonine protein kinase complex A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. http://purl.obolibrary.org/obo/GO_0009348 ornithine carbamoyltransferase complex http://purl.obolibrary.org/obo/GO_1990234 transferase complex A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline. http://purl.obolibrary.org/obo/GO_0009349 riboflavin synthase complex http://purl.obolibrary.org/obo/GO_1990234 transferase complex An flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine. http://purl.obolibrary.org/obo/GO_0010573 vascular endothelial growth factor production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of vascular endothelial growth factor production due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0015267 channel activity http://purl.obolibrary.org/obo/GO_0022803 passive transmembrane transporter activity Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules. http://purl.obolibrary.org/obo/GO_0016272 prefoldin complex http://purl.obolibrary.org/obo/GO_0043234 protein complex A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics. http://purl.obolibrary.org/obo/GO_0016507 mitochondrial fatty acid beta-oxidation multienzyme complex http://purl.obolibrary.org/obo/GO_0036125 fatty acid beta-oxidation multienzyme complex A complex that includes the long-chain 3-hydroxyacyl-CoA dehydrogenase and long-chain enoyl-CoA hydratase activities in two subunits (alpha and beta), catalyzing two steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix. http://purl.obolibrary.org/obo/GO_0016533 cyclin-dependent protein kinase 5 holoenzyme complex http://purl.obolibrary.org/obo/GO_0032991 macromolecular complex A protein complex that activates cyclin-dependent kinase 5; composed of regulatory and catalytic subunits. http://purl.obolibrary.org/obo/GO_0016772 transferase activity, transferring phosphorus-containing groups http://purl.obolibrary.org/obo/GO_0016740 transferase activity Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). http://purl.obolibrary.org/obo/GO_0017053 transcriptional repressor complex http://purl.obolibrary.org/obo/GO_0032991 macromolecular complex A protein complex that possesses activity that prevents or downregulates transcription. http://purl.obolibrary.org/obo/GO_0017101 aminoacyl-tRNA synthetase multienzyme complex http://purl.obolibrary.org/obo/GO_0044424 intracellular part A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates. http://purl.obolibrary.org/obo/GO_0017109 glutamate-cysteine ligase complex http://purl.obolibrary.org/obo/GO_1902494 catalytic complex An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine. http://purl.obolibrary.org/obo/GO_0019222 regulation of metabolic process http://purl.obolibrary.org/obo/GO_0050789 regulation of biological process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism. http://purl.obolibrary.org/obo/GO_0019904 protein domain specific binding http://purl.obolibrary.org/obo/GO_0005515 protein binding Interacting selectively and non-covalently with a specific domain of a protein. http://purl.obolibrary.org/obo/GO_0022803 passive transmembrane transporter activity http://purl.obolibrary.org/obo/GO_0022857 transmembrane transporter activity Enables the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient. http://purl.obolibrary.org/obo/GO_0030126 COPI vesicle coat http://purl.obolibrary.org/obo/GO_0030120 vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state. http://purl.obolibrary.org/obo/GO_0031010 ISWI-type complex http://purl.obolibrary.org/obo/GO_0070603 SWI/SNF superfamily-type complex Any nuclear protein complex that contains an ATPase subunit of the imitation switch (ISWI) family. ISWI ATPases are involved in assembling chromatin and in sliding and spacing nucleosomes to regulate transcription of nuclear RNA polymerases I, II, and III and also DNA replication, recombination and repair. http://purl.obolibrary.org/obo/GO_0031090 organelle membrane http://purl.obolibrary.org/obo/GO_0044422 organelle part A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle. http://purl.obolibrary.org/obo/GO_0031211 endoplasmic reticulum palmitoyltransferase complex http://purl.obolibrary.org/obo/GO_0044432 endoplasmic reticulum part A complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C16:0) or other long-chain fatty acids to proteins at a cysteine residue. http://purl.obolibrary.org/obo/GO_0036125 fatty acid beta-oxidation multienzyme complex http://purl.obolibrary.org/obo/GO_0032991 macromolecular complex A multienzyme complex possessing three kinds of enzymes that catalyze the chain reactions in the fatty acid beta-oxidation cycle, enoyl-CoA hydratase (ECH), 3-hydroxyacyl-CoA dehydrogenase (HACD), and acetyl-CoA C-acyltransferase (KACT). http://purl.obolibrary.org/obo/GO_0036454 growth factor complex http://purl.obolibrary.org/obo/GO_0043234 protein complex A protein complex that has growth factor activity. http://purl.obolibrary.org/obo/GO_0042709 succinate-CoA ligase complex http://purl.obolibrary.org/obo/GO_0045239 tricarboxylic acid cycle enzyme complex A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP. http://purl.obolibrary.org/obo/GO_0043228 non-membrane-bounded organelle http://purl.obolibrary.org/obo/GO_0043226 organelle Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes. http://purl.obolibrary.org/obo/GO_0043565 sequence-specific DNA binding http://purl.obolibrary.org/obo/GO_0003677 DNA binding Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. http://purl.obolibrary.org/obo/GO_0044440 endosomal part http://purl.obolibrary.org/obo/GO_0044433 cytoplasmic vesicle part Any constituent part of an endosome, a membrane-bounded organelle to which materials ingested by endocytosis are delivered. http://purl.obolibrary.org/obo/GO_0044446 intracellular organelle part http://purl.obolibrary.org/obo/GO_0044424 intracellular part A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane. http://purl.obolibrary.org/obo/GO_0045117 azole transport http://purl.obolibrary.org/obo/GO_0071705 nitrogen compound transport The directed movement of azoles, heterocyclic compounds found in many biologically important substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. http://purl.obolibrary.org/obo/GO_0045244 succinate-CoA ligase complex (GDP-forming) http://purl.obolibrary.org/obo/GO_0042709 succinate-CoA ligase complex A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP. http://purl.obolibrary.org/obo/GO_0051171 regulation of nitrogen compound metabolic process http://purl.obolibrary.org/obo/GO_0019222 regulation of metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds. http://purl.obolibrary.org/obo/GO_0065009 regulation of molecular function http://purl.obolibrary.org/obo/GO_0065007 biological regulation Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding. http://purl.obolibrary.org/obo/GO_0070069 cytochrome complex http://purl.obolibrary.org/obo/GO_0043234 protein complex A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. http://purl.obolibrary.org/obo/GO_0070603 SWI/SNF superfamily-type complex http://purl.obolibrary.org/obo/GO_0044428 nuclear part A protein complex that contains an ortholog of the Saccharomyces ATPase Swi2/Snf2 as one of the core components and mediates assembly of nucleosomes, changes to the spacing or structure of nucleosomes, or some combination of those activities in a manner that requires ATP. http://purl.obolibrary.org/obo/GO_0071840 cellular component organization or biogenesis http://purl.obolibrary.org/obo/GO_0008150 biological_process A process that results in the biosynthesis of constituent macromolecules, assembly, arrangement of constituent parts, or disassembly of a cellular component. http://purl.obolibrary.org/obo/GO_0090571 RNA polymerase II transcription repressor complex http://purl.obolibrary.org/obo/GO_0090568 nuclear transcriptional repressor complex A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase II promoter. http://purl.obolibrary.org/obo/GO_0098636 protein complex involved in cell adhesion http://purl.obolibrary.org/obo/GO_0032991 macromolecular complex Any protein complex that is capable of carrying out some part of the process of cell adhesion to the cell matrix or to another cell. http://purl.obolibrary.org/obo/GO_1902495 transmembrane transporter complex http://purl.obolibrary.org/obo/GO_1990351 transporter complex A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other. http://purl.obolibrary.org/obo/GO_0070018 transforming growth factor beta type I receptor homodimeric complex http://purl.obolibrary.org/obo/GO_0070022 transforming growth factor beta receptor complex A receptor complex that consists of two transforming growth factor beta (TGF-beta) type I receptor monomers. TGF-beta type I receptor dimers form in the presence or absence of ligand, and can associate with ligand-bound TGF-beta type II receptor dimers. http://purl.obolibrary.org/obo/GO_0070019 transforming growth factor beta type II receptor homodimeric complex http://purl.obolibrary.org/obo/GO_0070022 transforming growth factor beta receptor complex A receptor complex that consists of two transforming growth factor beta (TGF-beta) type II receptor monomers. TGF-beta type II receptor dimers form in the presence or absence of ligand, and upon ligand binding can associate with TGF-beta type I receptor dimers. http://purl.obolibrary.org/obo/GO_0070022 transforming growth factor beta receptor complex http://purl.obolibrary.org/obo/GO_1902554 serine/threonine protein kinase complex A homodimeric receptor complex that consists of two TGF-beta receptor monomers. http://purl.obolibrary.org/obo/GO_0070187 shelterin complex http://purl.obolibrary.org/obo/GO_0000783 nuclear telomere cap complex A nuclear telomere cap complex that is formed by the association of telomeric ssDNA- and dsDNA-binding proteins with telomeric DNA, and is involved in telomere protection and recruitment of telomerase. The complex is known to contain TERF1, TERF2, POT1, RAP1, TINF2 and ACD in mammalian cells, and Pot1, Tpz1, Rap1, Rif1, Rif2 and Taz1 in Schizosaccharomyces. Taz1 and Rap1 (or their mammalian equivalents) form a dsDNA-binding subcomplex, Pot1 and Tpz1 form an ssDNA-binding subcomplex, and the two subcomplexes are bridged by Poz1, which acts as an effector molecule along with Ccq1. http://purl.obolibrary.org/obo/GO_0070358 actin polymerization-dependent cell motility http://purl.obolibrary.org/obo/GO_0048870 cell motility A process involved in the controlled movement of a bacterial cell powered by the continuous polymerization of actin at one pole of the cell. http://purl.obolibrary.org/obo/GO_0070443 Mad-Max complex http://purl.obolibrary.org/obo/GO_0090571 RNA polymerase II transcription repressor complex A transcriptional repressor complex that consists of a heterodimer of the bHLH-ZIP proteins Mad and Max. http://purl.obolibrary.org/obo/GO_0070691 P-TEFb complex http://purl.obolibrary.org/obo/GO_0008024 cyclin/CDK positive transcription elongation factor complex A dimeric positive transcription elongation factor complex b that comprises a cyclin-dependent kinase containing the catalytic subunit, Cdk9, and a regulatory subunit, cyclin T. http://purl.obolibrary.org/obo/GO_0070743 interleukin-23 complex http://purl.obolibrary.org/obo/GO_0043234 protein complex A protein complex that is composed of an interleukin-23 alpha (p19, product of the IL23A gene) and an interleukin-12 beta (p40, product of the IL12B gene) subunit and is secreted into the extracellular space. http://purl.obolibrary.org/obo/GO_0071141 SMAD protein complex http://purl.obolibrary.org/obo/GO_0044424 intracellular part A protein complex that consists of only SMAD proteins; may be homomeric or heteromeric. http://purl.obolibrary.org/obo/GO_0071145 SMAD2-SMAD4 protein complex http://purl.obolibrary.org/obo/GO_0071141 SMAD protein complex A heteromeric SMAD protein complex that contains SMAD2 and SMAD4. http://purl.obolibrary.org/obo/GO_0071605 monocyte chemotactic protein-1 production http://purl.obolibrary.org/obo/GO_0032602 chemokine production The appearance of monocyte chemotactic protein-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0071606 chemokine (C-C motif) ligand 4 production http://purl.obolibrary.org/obo/GO_0032602 chemokine production The appearance of chemokine (C-C motif) ligand 4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0071607 macrophage inflammatory protein-1 gamma production http://purl.obolibrary.org/obo/GO_0032602 chemokine production The appearance of macrophage inflammatory protein-1 gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0071608 macrophage inflammatory protein-1 alpha production http://purl.obolibrary.org/obo/GO_0032602 chemokine production The appearance of macrophage inflammatory protein 1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0071609 chemokine (C-C motif) ligand 5 production http://purl.obolibrary.org/obo/GO_0032602 chemokine production The appearance of chemokine (C-C motif) ligand 5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0071610 chemokine (C-C motif) ligand 1 production http://purl.obolibrary.org/obo/GO_0032602 chemokine production The appearance of chemokine (C-C motif) ligand 1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0071611 granulocyte colony-stimulating factor production http://purl.obolibrary.org/obo/GO_0001816 cytokine production The appearance of granulocyte colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0071612 IP-10 production http://purl.obolibrary.org/obo/GO_0032602 chemokine production The appearance of IP-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0071613 granzyme B production http://purl.obolibrary.org/obo/GO_0002440 production of molecular mediator of immune response The appearance of granzyme B due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0071924 chemokine (C-C motif) ligand 22 production http://purl.obolibrary.org/obo/GO_0032602 chemokine production The appearance of chemokine (C-C motif) ligand 22 (CCL22) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/GO_0071943 Myc-Max complex http://purl.obolibrary.org/obo/GO_0090575 RNA polymerase II transcription factor complex A transcription factor complex that consists of a heterodimer of the bHLH-ZIP proteins Myc and Max. http://purl.obolibrary.org/obo/GO_0072535 tumor necrosis factor (ligand) superfamily member 11 production http://purl.obolibrary.org/obo/GO_0071706 tumor necrosis factor superfamily cytokine production The appearance of tumor necrosis factor superfamily member 11 (TNFSF11; RANKL) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. http://purl.obolibrary.org/obo/XAO_0000000 Xenopus anatomical entity http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity Entity that is either an individual member of Xenopus or constitutes the structural organization of an individual member Xenopus. http://purl.obolibrary.org/obo/BFO_0000148 zero-dimensional temporal region http://purl.obolibrary.org/obo/BFO_0000008 temporal region temporal instant. http://purl.obolibrary.org/obo/CHEBI_38295 azabicycloalkane http://purl.obolibrary.org/obo/CHEBI_38101 organonitrogen heterocyclic compound http://purl.obolibrary.org/obo/CHEBI_22728 benzopyrrole http://purl.obolibrary.org/obo/CHEBI_33833 heteroarene http://purl.obolibrary.org/obo/CHEBI_38086 benzoxathiole http://purl.obolibrary.org/obo/CHEBI_38104 oxacycle http://purl.obolibrary.org/obo/CHEBI_46969 benzoxazine http://purl.obolibrary.org/obo/CHEBI_38104 oxacycle http://purl.obolibrary.org/obo/CHEBI_35875 imidazopyrimidine http://purl.obolibrary.org/obo/CHEBI_33833 heteroarene http://purl.obolibrary.org/obo/CHEBI_38297 thiabicycloalkane http://purl.obolibrary.org/obo/CHEBI_38106 organosulfur heterocyclic compound http://purl.obolibrary.org/obo/CHEBI_38106 organosulfur heterocyclic compound http://purl.obolibrary.org/obo/CHEBI_24532 organic heterocyclic compound http://purl.obolibrary.org/obo/CHEBI_35350 hydroxy steroid http://purl.obolibrary.org/obo/CHEBI_35341 steroid http://purl.obolibrary.org/obo/CHEBI_39206 dibenzopyridine http://purl.obolibrary.org/obo/CHEBI_26979 organic heterotricyclic compound http://purl.obolibrary.org/obo/CHEBI_46952 oxazinane http://purl.obolibrary.org/obo/CHEBI_38104 oxacycle http://purl.obolibrary.org/obo/CHEBI_33670 heteromonocyclic compound http://purl.obolibrary.org/obo/CHEBI_33595 cyclic compound http://purl.obolibrary.org/obo/CHEBI_33671 heteropolycyclic compound http://purl.obolibrary.org/obo/CHEBI_33635 polycyclic compound http://purl.obolibrary.org/obo/CHEBI_35740 liposaccharide http://purl.obolibrary.org/obo/CHEBI_63299 carbohydrate derivative http://purl.obolibrary.org/obo/CHEBI_37586 sodium phosphate http://purl.obolibrary.org/obo/CHEBI_26714 sodium salt http://purl.obolibrary.org/obo/CHEBI_37015 ribonucleoside 5'-phosphate http://purl.obolibrary.org/obo/CHEBI_36976 nucleotide http://purl.obolibrary.org/obo/CHEBI_26561 ribonucleotide http://purl.obolibrary.org/obo/CHEBI_25900 aldopentose phosphate http://purl.obolibrary.org/obo/CHEBI_27171 organic heterobicyclic compound http://purl.obolibrary.org/obo/CHEBI_33672 heterobicyclic compound http://purl.obolibrary.org/obo/CHEBI_35259 benzofurans http://purl.obolibrary.org/obo/CHEBI_38104 oxacycle http://purl.obolibrary.org/obo/CHEBI_38164 organic heteropentacyclic compound http://purl.obolibrary.org/obo/CHEBI_38166 organic heteropolycyclic compound http://purl.obolibrary.org/obo/CHEBI_37096 adenosine 5'-phosphate http://purl.obolibrary.org/obo/CHEBI_37021 purine ribonucleoside 5'-monophosphate http://purl.obolibrary.org/obo/CHEBI_23528 cytochalasin http://purl.obolibrary.org/obo/CHEBI_22728 benzopyrrole http://purl.obolibrary.org/obo/CHEBI_36871 inorganic radical http://purl.obolibrary.org/obo/CHEBI_24835 inorganic molecular entity http://purl.obolibrary.org/obo/CHEBI_33775 lanthanoid molecular entity http://purl.obolibrary.org/obo/CHEBI_23367 molecular entity http://purl.obolibrary.org/obo/CHEBI_36520 oligoglycosylceramide http://purl.obolibrary.org/obo/CHEBI_17761 ceramide http://purl.obolibrary.org/obo/CHEBI_37121 guanosine 5'-phosphate http://purl.obolibrary.org/obo/CHEBI_24455 guanosine phosphate http://purl.obolibrary.org/obo/CHEBI_23114 chloride salt http://purl.obolibrary.org/obo/CHEBI_33958 halide salt http://purl.obolibrary.org/obo/CHEBI_38166 organic heteropolycyclic compound http://purl.obolibrary.org/obo/CHEBI_33671 heteropolycyclic compound http://purl.obolibrary.org/obo/CHEBI_25693 organic heteromonocyclic compound http://purl.obolibrary.org/obo/CHEBI_33670 heteromonocyclic compound http://purl.obolibrary.org/obo/CHEBI_52625 inorganic hydroxy compound http://purl.obolibrary.org/obo/CHEBI_24835 inorganic molecular entity http://purl.obolibrary.org/obo/CHEBI_35605 carbon oxoacid http://purl.obolibrary.org/obo/CHEBI_36963 organooxygen compound http://purl.obolibrary.org/obo/CHEBI_24839 inorganic salt http://purl.obolibrary.org/obo/CHEBI_24866 salt http://purl.obolibrary.org/obo/CHEBI_36914 inorganic ion http://purl.obolibrary.org/obo/CHEBI_24870 ion http://purl.obolibrary.org/obo/CHEBI_49637 hydrogen atom http://purl.obolibrary.org/obo/CHEBI_33250 atom http://purl.obolibrary.org/obo/CHEBI_33260 elemental hydrogen http://purl.obolibrary.org/obo/CHEBI_33608 hydrogen molecular entity http://purl.obolibrary.org/obo/CHEBI_33242 inorganic hydride http://purl.obolibrary.org/obo/CHEBI_33692 hydrides http://purl.obolibrary.org/obo/CHEBI_38702 inorganic sodium salt http://purl.obolibrary.org/obo/CHEBI_26714 sodium salt http://purl.obolibrary.org/obo/CHEBI_36093 inorganic chloride http://purl.obolibrary.org/obo/CHEBI_23114 chloride salt http://purl.obolibrary.org/obo/CHEBI_33958 halide salt http://purl.obolibrary.org/obo/CHEBI_37578 halide http://purl.obolibrary.org/obo/CHEBI_35479 alkali metal salt http://purl.obolibrary.org/obo/CHEBI_33296 alkali metal molecular entity http://purl.obolibrary.org/obo/CHEBI_23906 monoatomic cation http://purl.obolibrary.org/obo/CHEBI_36916 cation http://purl.obolibrary.org/obo/CHEBI_24867 monoatomic ion http://purl.obolibrary.org/obo/CHEBI_33238 monoatomic entity http://purl.obolibrary.org/obo/CHEBI_28659 phosphorus atom http://purl.obolibrary.org/obo/CHEBI_33250 atom http://purl.obolibrary.org/obo/CHEBI_25703 organic phosphate http://purl.obolibrary.org/obo/CHEBI_26079 phosphoric acid derivative http://purl.obolibrary.org/obo/CHEBI_36359 phosphorus oxoacid derivative http://purl.obolibrary.org/obo/CHEBI_33241 oxoacid derivative http://purl.obolibrary.org/obo/CHEBI_37021 purine ribonucleoside 5'-monophosphate http://purl.obolibrary.org/obo/CHEBI_37010 ribonucleoside 5'-monophosphate http://purl.obolibrary.org/obo/CHEBI_37038 purine ribonucleoside 5'-diphosphate http://purl.obolibrary.org/obo/CHEBI_25608 nucleoside phosphate http://purl.obolibrary.org/obo/CHEBI_37045 purine ribonucleoside 5'-triphosphate http://purl.obolibrary.org/obo/CHEBI_25608 nucleoside phosphate http://purl.obolibrary.org/obo/CHEBI_26397 purine ribonucleoside monophosphate http://purl.obolibrary.org/obo/CHEBI_17188 nucleoside 5'-monophosphate http://purl.obolibrary.org/obo/CHEBI_37010 ribonucleoside 5'-monophosphate http://purl.obolibrary.org/obo/CHEBI_37015 ribonucleoside 5'-phosphate http://purl.obolibrary.org/obo/CHEBI_33251 monoatomic hydrogen http://purl.obolibrary.org/obo/CHEBI_33260 elemental hydrogen http://purl.obolibrary.org/obo/CHEBI_25585 nonmetal atom http://purl.obolibrary.org/obo/CHEBI_33250 atom http://purl.obolibrary.org/obo/CHEBI_26082 phosphorus molecular entity http://purl.obolibrary.org/obo/CHEBI_33302 pnictogen molecular entity http://purl.obolibrary.org/obo/CHEBI_51143 nitrogen molecular entity http://purl.obolibrary.org/obo/CHEBI_33302 pnictogen molecular entity http://purl.obolibrary.org/obo/CHEBI_25806 oxygen molecular entity http://purl.obolibrary.org/obo/CHEBI_33304 chalcogen molecular entity http://purl.obolibrary.org/obo/CHEBI_36902 chalcogen hydride http://purl.obolibrary.org/obo/CHEBI_33242 inorganic hydride http://purl.obolibrary.org/obo/CHEBI_26835 sulfur molecular entity http://purl.obolibrary.org/obo/CHEBI_33304 chalcogen molecular entity http://purl.obolibrary.org/obo/CHEBI_33485 chalcogen oxoanion http://purl.obolibrary.org/obo/CHEBI_35406 oxoanion http://purl.obolibrary.org/obo/CHEBI_33561 d-block element atom http://purl.obolibrary.org/obo/CHEBI_27081 transition element atom http://purl.obolibrary.org/obo/CHEBI_27889 lead(0) http://purl.obolibrary.org/obo/CHEBI_33582 carbon group molecular entity http://purl.obolibrary.org/obo/CHEBI_24471 halogen molecular entity http://purl.obolibrary.org/obo/CHEBI_33675 p-block molecular entity http://purl.obolibrary.org/obo/CHEBI_33582 carbon group molecular entity http://purl.obolibrary.org/obo/CHEBI_33675 p-block molecular entity http://purl.obolibrary.org/obo/CHEBI_33659 organic aromatic compound http://purl.obolibrary.org/obo/CHEBI_33595 cyclic compound http://purl.obolibrary.org/obo/CHEBI_51958 organic polycyclic compound http://purl.obolibrary.org/obo/CHEBI_33635 polycyclic compound http://purl.obolibrary.org/obo/CHEBI_26079 phosphoric acid derivative http://purl.obolibrary.org/obo/CHEBI_36359 phosphorus oxoacid derivative http://purl.obolibrary.org/obo/CHEBI_36915 inorganic cation http://purl.obolibrary.org/obo/CHEBI_36916 cation http://purl.obolibrary.org/obo/CHEBI_33241 oxoacid derivative http://purl.obolibrary.org/obo/CHEBI_37577 heteroatomic molecular entity http://purl.obolibrary.org/obo/CHEBI_25900 aldopentose phosphate http://purl.obolibrary.org/obo/CHEBI_33447 phospho sugar http://purl.obolibrary.org/obo/CHEBI_38087 2,1-benzoxathiole http://purl.obolibrary.org/obo/CHEBI_38086 benzoxathiole http://purl.obolibrary.org/obo/CHEBI_26440 pyrimidine nucleoside http://purl.obolibrary.org/obo/CHEBI_33838 nucleoside http://purl.obolibrary.org/obo/BFO_0000002 continuant http://purl.obolibrary.org/obo/BFO_0000001 entity http://purl.obolibrary.org/obo/BFO_0000003 occurrent http://purl.obolibrary.org/obo/BFO_0000001 entity http://purl.obolibrary.org/obo/BFO_0000008 temporal region http://purl.obolibrary.org/obo/BFO_0000003 occurrent http://purl.obolibrary.org/obo/BFO_0000011 spatiotemporal region http://purl.obolibrary.org/obo/BFO_0000003 occurrent http://purl.obolibrary.org/obo/BFO_0000040 material entity http://purl.obolibrary.org/obo/BFO_0000004 independent continuant http://purl.obolibrary.org/obo/BFO_0000141 immaterial entity http://purl.obolibrary.org/obo/BFO_0000004 independent continuant http://purl.obolibrary.org/obo/BFO_0000009 two-dimensional spatial region http://purl.obolibrary.org/obo/BFO_0000006 spatial region http://purl.obolibrary.org/obo/BFO_0000018 zero-dimensional spatial region http://purl.obolibrary.org/obo/BFO_0000006 spatial region http://purl.obolibrary.org/obo/BFO_0000026 one-dimensional spatial region http://purl.obolibrary.org/obo/BFO_0000006 spatial region http://purl.obolibrary.org/obo/BFO_0000028 three-dimensional spatial region http://purl.obolibrary.org/obo/BFO_0000006 spatial region http://purl.obolibrary.org/obo/BFO_0000038 one-dimensional temporal region http://purl.obolibrary.org/obo/BFO_0000008 temporal region http://purl.obolibrary.org/obo/BFO_0000182 history http://purl.obolibrary.org/obo/BFO_0000015 process http://purl.obolibrary.org/obo/BFO_0000034 function http://purl.obolibrary.org/obo/BFO_0000016 disposition http://purl.obolibrary.org/obo/BFO_0000016 disposition http://purl.obolibrary.org/obo/BFO_0000017 realizable entity http://purl.obolibrary.org/obo/BFO_0000023 role http://purl.obolibrary.org/obo/BFO_0000017 realizable entity http://purl.obolibrary.org/obo/BFO_0000017 realizable entity http://purl.obolibrary.org/obo/BFO_0000020 specifically dependent continuant http://purl.obolibrary.org/obo/BFO_0000019 quality http://purl.obolibrary.org/obo/BFO_0000020 specifically dependent continuant http://purl.obolibrary.org/obo/BFO_0000024 fiat object part http://purl.obolibrary.org/obo/BFO_0000040 material entity http://purl.obolibrary.org/obo/BFO_0000027 object aggregate http://purl.obolibrary.org/obo/BFO_0000040 material entity http://purl.obolibrary.org/obo/BFO_0000030 object http://purl.obolibrary.org/obo/BFO_0000040 material entity http://purl.obolibrary.org/obo/BFO_0000142 one-dimensional continuant fiat boundary http://purl.obolibrary.org/obo/BFO_0000140 continuant fiat boundary http://purl.obolibrary.org/obo/BFO_0000146 two-dimensional continuant fiat boundary http://purl.obolibrary.org/obo/BFO_0000140 continuant fiat boundary http://purl.obolibrary.org/obo/BFO_0000147 zero-dimensional continuant fiat boundary http://purl.obolibrary.org/obo/BFO_0000140 continuant fiat boundary http://purl.obolibrary.org/obo/BFO_0000006 spatial region http://purl.obolibrary.org/obo/BFO_0000141 immaterial entity http://purl.obolibrary.org/obo/BFO_0000029 site http://purl.obolibrary.org/obo/BFO_0000141 immaterial entity http://purl.obolibrary.org/obo/NCBITaxon_10239 Viruses http://purl.obolibrary.org/obo/OBI_0100026 organism http://purl.obolibrary.org/obo/NCBITaxon_2157 Archaea http://purl.obolibrary.org/obo/OBI_0100026 organism http://purl.obolibrary.org/obo/NCBITaxon_2 Bacteria http://purl.obolibrary.org/obo/OBI_0100026 organism http://purl.obolibrary.org/obo/NCBITaxon_2759 Eukaryota http://purl.obolibrary.org/obo/OBI_0100026 organism http://purl.obolibrary.org/obo/PATO_0001894 phenotypic sex http://purl.obolibrary.org/obo/PATO_0000047 biological sex http://purl.obolibrary.org/obo/CHEBI_19255 pyrimidine 2'-deoxyribonucleoside http://purl.obolibrary.org/obo/CHEBI_68472 pyrimidine deoxyribonucleoside http://purl.obolibrary.org/obo/CHEBI_18274 2'-deoxyribonucleoside http://purl.obolibrary.org/obo/CHEBI_47017 tetrahydrofuranol http://purl.obolibrary.org/obo/CHEBI_47017 tetrahydrofuranol http://purl.obolibrary.org/obo/CHEBI_26912 oxolanes http://purl.obolibrary.org/obo/CHEBI_42191 ethylenediaminetetraacetic acid http://purl.obolibrary.org/obo/CHEBI_35742 tetracarboxylic acid http://purl.obolibrary.org/obo/CHEBI_4705 double-stranded DNA http://purl.obolibrary.org/obo/CHEBI_16991 deoxyribonucleic acid http://purl.obolibrary.org/obo/CHEBI_26558 ribonucleoside monophosphate http://purl.obolibrary.org/obo/CHEBI_17188 nucleoside 5'-monophosphate http://purl.obolibrary.org/obo/CHEBI_29281 alkyl sulfate http://purl.obolibrary.org/obo/CHEBI_26819 sulfuric ester http://purl.obolibrary.org/obo/CHEBI_37875 acyl sulfate http://purl.obolibrary.org/obo/CHEBI_37787 acyclic mixed acid anhydride http://purl.obolibrary.org/obo/CHEBI_29191 hydroxyl http://purl.obolibrary.org/obo/CHEBI_61073 oxygen radical http://purl.obolibrary.org/obo/CHEBI_23636 deoxyribonucleoside http://purl.obolibrary.org/obo/CHEBI_33838 nucleoside http://purl.obolibrary.org/obo/CHEBI_26394 purine nucleoside http://purl.obolibrary.org/obo/CHEBI_26401 purines http://purl.obolibrary.org/obo/CHEBI_26816 carbohydrate phosphate http://purl.obolibrary.org/obo/CHEBI_37734 phosphoric ester http://purl.obolibrary.org/obo/CHEBI_33693 oxygen hydride http://purl.obolibrary.org/obo/CHEBI_36902 chalcogen hydride http://purl.obolibrary.org/obo/NCBITaxon_4896 Schizosaccharomyces pombe http://purl.obolibrary.org/obo/NCBITaxon_4890 Ascomycota http://purl.obolibrary.org/obo/NCBITaxon_4932 Saccharomyces cerevisiae http://purl.obolibrary.org/obo/NCBITaxon_4890 Ascomycota http://purl.obolibrary.org/obo/CHEBI_37987 Cy3 dye http://purl.obolibrary.org/obo/CHEBI_37960 cyanine dye http://purl.obolibrary.org/obo/CHEBI_37989 Cy5 dye http://purl.obolibrary.org/obo/CHEBI_37960 cyanine dye http://purl.obolibrary.org/obo/CHEBI_46867 indolyl carboxylic acid http://purl.obolibrary.org/obo/CHEBI_33575 carboxylic acid http://purl.obolibrary.org/obo/CHEBI_26399 purine ribonucleoside http://purl.obolibrary.org/obo/CHEBI_18254 ribonucleoside http://purl.obolibrary.org/obo/CHEBI_51756 Alexa Fluor 532 http://purl.obolibrary.org/obo/CHEBI_38164 organic heteropentacyclic compound http://purl.obolibrary.org/obo/CHEBI_17552 GDP http://purl.obolibrary.org/obo/CHEBI_37121 guanosine 5'-phosphate http://purl.obolibrary.org/obo/CHEBI_15996 GTP http://purl.obolibrary.org/obo/CHEBI_37121 guanosine 5'-phosphate http://purl.obolibrary.org/obo/CHEBI_22256 adenosine phosphate http://purl.obolibrary.org/obo/CHEBI_61296 adenyl ribonucleotide http://purl.obolibrary.org/obo/CHEBI_24455 guanosine phosphate http://purl.obolibrary.org/obo/CHEBI_26399 purine ribonucleoside http://purl.obolibrary.org/obo/CHEBI_17188 nucleoside 5'-monophosphate http://purl.obolibrary.org/obo/CHEBI_25608 nucleoside phosphate http://purl.obolibrary.org/obo/CHEBI_37734 phosphoric ester http://purl.obolibrary.org/obo/CHEBI_35701 ester http://purl.obolibrary.org/obo/CHEBI_47857 ureas http://purl.obolibrary.org/obo/CHEBI_33256 primary amide http://purl.obolibrary.org/obo/CHEBI_17137 hydrogensulfite http://purl.obolibrary.org/obo/CHEBI_33482 sulfur oxoanion http://purl.obolibrary.org/obo/CHEBI_33482 sulfur oxoanion http://purl.obolibrary.org/obo/CHEBI_33485 chalcogen oxoanion http://purl.obolibrary.org/obo/CHEBI_33424 sulfur oxoacid derivative http://purl.obolibrary.org/obo/CHEBI_33241 oxoacid derivative http://purl.obolibrary.org/obo/CHEBI_30682 ruthenium atom http://purl.obolibrary.org/obo/CHEBI_27081 transition element atom http://purl.obolibrary.org/obo/CHEBI_33375 gadolinium atom http://purl.obolibrary.org/obo/CHEBI_33562 f-block element atom http://purl.obolibrary.org/obo/CHEBI_33376 terbium atom http://purl.obolibrary.org/obo/CHEBI_33562 f-block element atom http://purl.obolibrary.org/obo/CHEBI_33319 lanthanoid atom http://purl.obolibrary.org/obo/CHEBI_33321 rare earth metal atom http://purl.obolibrary.org/obo/CHEBI_33552 sulfonic acid derivative http://purl.obolibrary.org/obo/CHEBI_33424 sulfur oxoacid derivative http://purl.obolibrary.org/obo/CHEBI_37826 sulfuric acid derivative http://purl.obolibrary.org/obo/CHEBI_33424 sulfur oxoacid derivative http://purl.obolibrary.org/obo/CHEBI_33356 iron group element atom http://purl.obolibrary.org/obo/CHEBI_27081 transition element atom http://purl.obolibrary.org/obo/CHEBI_33350 chromium group element atom http://purl.obolibrary.org/obo/CHEBI_27081 transition element atom http://purl.obolibrary.org/obo/CHEBI_33358 cobalt group element atom http://purl.obolibrary.org/obo/CHEBI_27081 transition element atom http://purl.obolibrary.org/obo/CHEBI_33635 polycyclic compound http://purl.obolibrary.org/obo/CHEBI_33595 cyclic compound http://purl.obolibrary.org/obo/CHEBI_33608 hydrogen molecular entity http://purl.obolibrary.org/obo/CHEBI_33674 s-block molecular entity http://purl.obolibrary.org/obo/CHEBI_35730 gadolinium coordination entity http://purl.obolibrary.org/obo/CHEBI_35729 gadolinium molecular entity http://purl.obolibrary.org/obo/CHEBI_35729 gadolinium molecular entity http://purl.obolibrary.org/obo/CHEBI_33775 lanthanoid molecular entity http://purl.obolibrary.org/obo/CHEBI_38835 xanthenes http://purl.obolibrary.org/obo/CHEBI_39203 dibenzopyran http://purl.obolibrary.org/obo/NCBITaxon_186625 Clupeocephala http://purl.obolibrary.org/obo/NCBITaxon_117571 Euteleostomi http://purl.obolibrary.org/obo/NCBITaxon_32524 Amniota http://purl.obolibrary.org/obo/NCBITaxon_117571 Euteleostomi http://purl.obolibrary.org/obo/NCBITaxon_6239 Caenorhabditis elegans http://purl.obolibrary.org/obo/NCBITaxon_1206794 Ecdysozoa http://purl.obolibrary.org/obo/NCBITaxon_7227 Drosophila melanogaster http://purl.obolibrary.org/obo/NCBITaxon_1206794 Ecdysozoa http://purl.obolibrary.org/obo/NCBITaxon_7955 Danio rerio http://purl.obolibrary.org/obo/NCBITaxon_186625 Clupeocephala http://purl.obolibrary.org/obo/NCBITaxon_8030 Salmo salar http://purl.obolibrary.org/obo/NCBITaxon_186625 Clupeocephala http://purl.obolibrary.org/obo/NCBITaxon_44689 Dictyostelium discoideum http://purl.obolibrary.org/obo/NCBITaxon_2759 Eukaryota http://purl.obolibrary.org/obo/NCBITaxon_5833 Plasmodium falciparum http://purl.obolibrary.org/obo/NCBITaxon_2759 Eukaryota http://purl.obolibrary.org/obo/NCBITaxon_33090 Viridiplantae http://purl.obolibrary.org/obo/NCBITaxon_2759 Eukaryota http://purl.obolibrary.org/obo/NCBITaxon_33154 Opisthokonta http://purl.obolibrary.org/obo/NCBITaxon_2759 Eukaryota http://purl.obolibrary.org/obo/NCBITaxon_9606 Homo sapiens http://purl.obolibrary.org/obo/NCBITaxon_314146 Euarchontoglires http://purl.obolibrary.org/obo/NCBITaxon_9989 Rodentia http://purl.obolibrary.org/obo/NCBITaxon_314146 Euarchontoglires http://purl.obolibrary.org/obo/NCBITaxon_40674 Mammalia http://purl.obolibrary.org/obo/NCBITaxon_32524 Amniota http://purl.obolibrary.org/obo/NCBITaxon_9031 Gallus gallus http://purl.obolibrary.org/obo/NCBITaxon_32524 Amniota http://purl.obolibrary.org/obo/NCBITaxon_3702 Arabidopsis thaliana http://purl.obolibrary.org/obo/NCBITaxon_33090 Viridiplantae http://purl.obolibrary.org/obo/NCBITaxon_4890 Ascomycota http://purl.obolibrary.org/obo/NCBITaxon_33154 Opisthokonta http://purl.obolibrary.org/obo/NCBITaxon_33213 Bilateria http://purl.obolibrary.org/obo/NCBITaxon_33154 Opisthokonta http://purl.obolibrary.org/obo/NCBITaxon_117571 Euteleostomi http://purl.obolibrary.org/obo/NCBITaxon_33213 Bilateria http://purl.obolibrary.org/obo/NCBITaxon_1206794 Ecdysozoa http://purl.obolibrary.org/obo/NCBITaxon_33213 Bilateria http://purl.obolibrary.org/obo/NCBITaxon_10090 Mus musculus http://purl.obolibrary.org/obo/NCBITaxon_39107 Murinae http://purl.obolibrary.org/obo/NCBITaxon_10116 Rattus norvegicus http://purl.obolibrary.org/obo/NCBITaxon_39107 Murinae http://purl.obolibrary.org/obo/NCBITaxon_314146 Euarchontoglires http://purl.obolibrary.org/obo/NCBITaxon_40674 Mammalia http://purl.obolibrary.org/obo/NCBITaxon_39107 Murinae http://purl.obolibrary.org/obo/NCBITaxon_9989 Rodentia http://purl.obolibrary.org/obo/ZFS_0100000 Stages http://purl.obolibrary.org/obo/UBERON_0000105 life cycle stage http://purl.obolibrary.org/obo/ZFA_0100000 zebrafish anatomical entity http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity http://purl.obolibrary.org/obo/CHEBI_51760 Alexa Fluor 546 http://purl.obolibrary.org/obo/CHEBI_38164 organic heteropentacyclic compound http://purl.obolibrary.org/obo/CHEBI_33321 rare earth metal atom http://purl.obolibrary.org/obo/CHEBI_27081 transition element atom http://purl.obolibrary.org/obo/CHEBI_33562 f-block element atom http://purl.obolibrary.org/obo/CHEBI_27081 transition element atom http://purl.obolibrary.org/obo/CHEBI_36631 acyclic carboxylic anhydride http://purl.obolibrary.org/obo/CHEBI_36608 acyclic acid anhydride http://purl.obolibrary.org/obo/CHEBI_36608 acyclic acid anhydride http://purl.obolibrary.org/obo/CHEBI_36606 acid anhydride http://purl.obolibrary.org/obo/CHEBI_37787 acyclic mixed acid anhydride http://purl.obolibrary.org/obo/CHEBI_36608 acyclic acid anhydride http://purl.obolibrary.org/obo/BFO_0000001 entity http://purl.obolibrary.org/obo/RO_0000056 participates in participates_in a relation between a continuant and a process, in which the continuant is somehow involved in the process http://purl.obolibrary.org/obo/RO_0000086 has quality has_quality a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0001000 derives from derives_from a relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity http://purl.obolibrary.org/obo/RO_0001025 located in located_in a relation between two independent continuants, the target and the location, in which the target is entirely within the location http://purl.obolibrary.org/obo/BFO_0000051 has part has_part a core relation that holds between a whole and its part http://purl.obolibrary.org/obo/RO_0000087 has role has_role a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/BFO_0000062 preceded by preceded_by x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. http://purl.obolibrary.org/obo/BFO_0000050 part of part_of a core relation that holds between a part and its whole http://purl.obolibrary.org/obo/BFO_0000066 occurs in unfolds_in b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t http://purl.obolibrary.org/obo/RO_0002160 only in taxon x only in taxon y if and only if x is in taxon y, and there is no other organism z such that y!=z a and x is in taxon z. http://purl.obolibrary.org/obo/BFO_0000063 precedes x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. http://purl.obolibrary.org/obo/RO_0002220 adjacent to x adjacent to y if and only if x and y share a boundary. http://purl.obolibrary.org/obo/RO_0002202 develops from x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y