Term IRI Term label Parent term IRI Parent term label Alternative term Definition http://purl.obolibrary.org/obo/IAO_0000027 data entity http://purl.obolibrary.org/obo/IAO_0000030 information content entity data item An information content entity that is intended to be one or more truthful statement(s) about something (modulo, e.g., measurement precision or other systematic errors) and is constructed/acquired by a method which reliably tends to produce (approximately) truthful statements. http://purl.obolibrary.org/obo/IAO_0000100 homogenous data collection http://purl.obolibrary.org/obo/IAO_0001000 data collection data set A data item that is an aggregate of other data items of the same type that have something in common. Averages and distributions can be determined for data sets. http://purl.obolibrary.org/obo/IAO_0001000 data collection http://purl.obolibrary.org/obo/IAO_0000027 data entity data set A data entity that consists of multiple data entities. http://purl.obolibrary.org/obo/PBPKO_04103 fraction of adipose mass http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment fraction of fat mass A dimensionless fraction of volume defined as the adipose mass volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_04110 volume of liver intracellular space http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment volume of hepatocytes A volume parameter representing the total volume of the hepatocytes in liver compartment. http://purl.obolibrary.org/obo/PBPKO_06064 amount in kidney rest lumen http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment amount in rest of kidney lumen The amount of compound in the rest of kidney lumen compartment. http://purl.obolibrary.org/obo/CHEBI_24636 proton http://purl.obolibrary.org/obo/COB_0000013 molecule Nuclear particle of charge number +1, spin ½ and rest mass of 1.007276470(12) u. http://purl.obolibrary.org/obo/BFO_0000002 continuant http://purl.obolibrary.org/obo/BFO_0000001 entity An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts. http://purl.obolibrary.org/obo/BFO_0000004 independent continuant http://purl.obolibrary.org/obo/BFO_0000002 continuant b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002]) http://purl.obolibrary.org/obo/BFO_0000015 process http://purl.obolibrary.org/obo/BFO_0000003 occurrent p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003]) http://purl.obolibrary.org/obo/BFO_0000017 realizable entity http://purl.obolibrary.org/obo/COB_0000502 characteristic A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances. http://purl.obolibrary.org/obo/BFO_0000020 specifically dependent continuant http://purl.obolibrary.org/obo/BFO_0000002 continuant b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003]) http://purl.obolibrary.org/obo/BFO_0000023 role http://purl.obolibrary.org/obo/BFO_0000017 realizable entity A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts. http://purl.obolibrary.org/obo/BFO_0000040 material entity http://purl.obolibrary.org/obo/BFO_0000004 independent continuant An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time. http://purl.obolibrary.org/obo/IAO_0000003 measurement unit label http://purl.obolibrary.org/obo/IAO_0000009 datum label A measurement unit label is as a label that is part of a scalar measurement datum and denotes a unit of measure. http://purl.obolibrary.org/obo/IAO_0000005 objective specification http://purl.obolibrary.org/obo/IAO_0000033 directive information entity A directive information entity that describes an intended process endpoint. When part of a plan specification the concretization is realized in a planned process in which the bearer tries to effect the world so that the process endpoint is achieved. http://purl.obolibrary.org/obo/IAO_0000009 datum label http://purl.obolibrary.org/obo/IAO_0000030 information content entity A label is a symbol that is part of some other datum and is used to either partially define the denotation of that datum or to provide a means for identifying the datum as a member of the set of data with the same label http://purl.obolibrary.org/obo/IAO_0000010 software http://purl.obolibrary.org/obo/IAO_0000104 plan specification Software is a plan specification composed of a series of instructions that can be interpreted by or directly executed by a processing unit. http://purl.obolibrary.org/obo/IAO_0000030 information content entity http://purl.obolibrary.org/obo/BFO_0000031 generically dependent continuant A generically dependent continuant that is about some thing. http://purl.obolibrary.org/obo/IAO_0000033 directive information entity http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity whose concretizations indicate to their bearer how to realize them in a process. http://purl.obolibrary.org/obo/IAO_0000037 dot plot http://purl.obolibrary.org/obo/IAO_0000038 graph A dot plot is a report graph which is a graphical representation of data where each data point is represented by a single dot placed on coordinates corresponding to data point values in particular dimensions. http://purl.obolibrary.org/obo/IAO_0000038 graph http://purl.obolibrary.org/obo/IAO_0000308 figure A diagram that presents one or more tuples of information by mapping those tuples in to a two dimensional space in a non arbitrary way. http://purl.obolibrary.org/obo/IAO_0000064 algorithm http://purl.obolibrary.org/obo/IAO_0000104 plan specification A plan specification which describes the inputs and output of mathematical functions as well as workflow of execution for achieving an predefined objective. Algorithms are realized usually by means of implementation as computer programs for execution by automata. http://purl.obolibrary.org/obo/IAO_0000078 curation status specification http://purl.obolibrary.org/obo/IAO_0000102 data about an ontology part The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value. http://purl.obolibrary.org/obo/IAO_0000098 data format specification http://purl.obolibrary.org/obo/IAO_0000033 directive information entity A data format specification is the information content borne by the document published defining the specification. Example: The ISO document specifying what encompasses an XML document; The instructions in a XSD file http://purl.obolibrary.org/obo/IAO_0000101 image http://purl.obolibrary.org/obo/IAO_0000308 figure An image is an affine projection to a two dimensional surface, of measurements of some quality of an entity or entities repeated at regular intervals across a spatial range, where the measurements are represented as color and luminosity on the projected on surface. http://purl.obolibrary.org/obo/IAO_0000102 data about an ontology part http://purl.obolibrary.org/obo/IAO_0000027 data entity Data about an ontology part is a data item about a part of an ontology, for example a term http://purl.obolibrary.org/obo/IAO_0000104 plan specification http://purl.obolibrary.org/obo/IAO_0000033 directive information entity A directive information entity with action specifications and objective specifications as parts, and that may be concretized as a realizable entity that, if realized, is realized in a process in which the bearer tries to achieve the objectives by taking the actions specified. http://purl.obolibrary.org/obo/IAO_0000179 histogram http://purl.obolibrary.org/obo/IAO_0000038 graph A histogram is a report graph which is a statistical description of a distribution in terms of occurrence frequencies of different event classes. http://purl.obolibrary.org/obo/IAO_0000180 heatmap http://purl.obolibrary.org/obo/IAO_0000038 graph A heatmap is a report graph which is a graphical representation of data where the values taken by a variable(s) are shown as colors in a two-dimensional map. http://purl.obolibrary.org/obo/IAO_0000183 dendrogram http://purl.obolibrary.org/obo/IAO_0000038 graph A dendrogram is a report graph which is a tree diagram frequently used to illustrate the arrangement of the clusters produced by a clustering algorithm. http://purl.obolibrary.org/obo/IAO_0000184 scatter plot http://purl.obolibrary.org/obo/IAO_0000038 graph A scatterplot is a graph which uses Cartesian coordinates to display values for two variables for a set of data. The data is displayed as a collection of points, each having the value of one variable determining the position on the horizontal axis and the value of the other variable determining the position on the vertical axis. http://purl.obolibrary.org/obo/IAO_0000225 obsolescence reason specification http://purl.obolibrary.org/obo/IAO_0000102 data about an ontology part The reason for which a term has been deprecated. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value. http://purl.obolibrary.org/obo/IAO_0000308 figure http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity consisting of a two dimensional arrangement of information content entities such that the arrangement itself is about something. http://purl.obolibrary.org/obo/IAO_0000310 document http://purl.obolibrary.org/obo/IAO_0000030 information content entity A collection of information content entities intended to be understood together as a whole http://purl.obolibrary.org/obo/IAO_0000409 denotator type http://purl.obolibrary.org/obo/IAO_0000102 data about an ontology part A denotator type indicates how a term should be interpreted from an ontological perspective. http://purl.obolibrary.org/obo/OBI_0000014 regulator role http://purl.obolibrary.org/obo/OBI_0000017 regulatory role a regulatory role involved with making and/or enforcing relevant legislation and governmental orders http://purl.obolibrary.org/obo/OBI_0000017 regulatory role http://purl.obolibrary.org/obo/BFO_0000023 role a role which inheres in material entities and is realized in the processes of making, enforcing or being defined by legislation or orders issued by a governmental body. http://purl.obolibrary.org/obo/OBI_0000018 material supplier role http://purl.obolibrary.org/obo/OBI_0000947 service provider role a role realized through the process of supplying materials such as animal subjects, reagents or other materials used in an investigation. http://purl.obolibrary.org/obo/OBI_0000023 classified data set http://purl.obolibrary.org/obo/IAO_0000100 homogenous data collection A data set that is produced as the output of a class prediction data transformation and consists of a data set with assigned class labels. http://purl.obolibrary.org/obo/OBI_0000112 specimen role http://purl.obolibrary.org/obo/BFO_0000023 role A role borne by a material entity that is obtained during a specimen collection process and that can be realized by performing measurements or observations on the specimen. http://purl.obolibrary.org/obo/OBI_0000245 organization http://purl.obolibrary.org/obo/BFO_0000040 material entity An entity that can bear roles, has members, and has a set of organization rules. Members of organizations are either organizations themselves or individual people. Members can bear specific organization member roles that are determined in the organization rules. The organization rules also determine how decisions are made on behalf of the organization by the organization members. http://purl.obolibrary.org/obo/OBI_0000260 plan http://purl.obolibrary.org/obo/BFO_0000017 realizable entity A plan is a realizable entity that is the inheres in a bearer who is committed to realizing it as a completely executed planned process. http://purl.obolibrary.org/obo/OBI_0000450 regulatory agency http://purl.obolibrary.org/obo/OBI_0000245 organization A regulatory agency is a organization that has responsibility over or for the legislation (acts and regulations) for a given sector of the government. http://purl.obolibrary.org/obo/OBI_0000571 manufacturer role http://purl.obolibrary.org/obo/BFO_0000023 role Manufacturer role is a role which inheres in a person or organization and which is realized by a manufacturing process. http://purl.obolibrary.org/obo/OBI_0000648 clustered data set http://purl.obolibrary.org/obo/IAO_0000100 homogenous data collection A data set that is produced as the output of a class discovery data transformation and consists of a data set with assigned discovered class labels. http://purl.obolibrary.org/obo/OBI_0000658 data representational model http://purl.obolibrary.org/obo/IAO_0000033 directive information entity An information content entity representing the relationships between data items. http://purl.obolibrary.org/obo/OBI_0000659 specimen collection process http://purl.obolibrary.org/obo/COB_0000035 completely executed planned process A planned process with the objective to obtain a material entity for potential use as an input upon which measurements or observations are performed. http://purl.obolibrary.org/obo/OBI_0000663 class prediction data transformation http://purl.obolibrary.org/obo/OBI_0200000 data transformation A class prediction data transformation (sometimes called supervised classification) is a data transformation that has objective class prediction. http://purl.obolibrary.org/obo/OBI_0000684 specimen collection objective http://purl.obolibrary.org/obo/IAO_0000005 objective specification A objective specification that is fulfilled by obtaining a material entity for potential use as an input upon which measurements or observations are performed. http://purl.obolibrary.org/obo/OBI_0000700 support vector machine http://purl.obolibrary.org/obo/OBI_0000663 class prediction data transformation A support vector machine is a data transformation with a class prediction objective based on the construction of a separating hyperplane that maximizes the margin between two data sets of vectors in n-dimensional space. http://purl.obolibrary.org/obo/OBI_0000704 decision tree induction objective http://purl.obolibrary.org/obo/OBI_0200166 data transformation objective A decision tree induction objective is a data transformation objective in which a tree-like graph of edges and nodes is created and from which the selection of each branch requires that some type of logical decision is made. http://purl.obolibrary.org/obo/OBI_0000707 decision tree building data transformation http://purl.obolibrary.org/obo/OBI_0200000 data transformation A decision tree building data transformation is a data transformation that has objective decision tree induction. http://purl.obolibrary.org/obo/OBI_0000713 GenePattern software http://purl.obolibrary.org/obo/IAO_0000010 software a software that provides access to more than 100 tools for gene expression analysis, proteomics, SNP analysis and common data processing tasks. http://purl.obolibrary.org/obo/OBI_0000726 peak matching http://purl.obolibrary.org/obo/OBI_0200000 data transformation Peak matching is a data transformation performed on a dataset of a graph of ordered data points (e.g. a spectrum) with the objective of pattern matching local maxima above a noise threshold http://purl.obolibrary.org/obo/OBI_0000727 k-nearest neighbors http://purl.obolibrary.org/obo/OBI_0200175 class discovery data transformation A k-nearest neighbors is a data transformation which achieves a class discovery or partitioning objective, in which an input data object with vector y is assigned to a class label based upon the k closest training data set points to y; where k is the largest value that class label is assigned. http://purl.obolibrary.org/obo/OBI_0000749 CART http://purl.obolibrary.org/obo/OBI_0000707 decision tree building data transformation A CART (classification and regression trees) is a data transformation method for producing a classification or regression model with a tree-based structure. http://purl.obolibrary.org/obo/OBI_0000792 statistical model validation http://purl.obolibrary.org/obo/OBI_0200171 partitioning data transformation A data transformation which assesses how the results of a statistical analysis will generalize to an independent data set. http://purl.obolibrary.org/obo/OBI_0000835 manufacturer http://purl.obolibrary.org/obo/BFO_0000040 material entity A person or organization that has a manufacturer role. http://purl.obolibrary.org/obo/OBI_0000947 service provider role http://purl.obolibrary.org/obo/BFO_0000023 role is a role which inheres in a person or organization and is realized in in a planned process which provides access to training, materials or execution of protocols for an organization or person http://purl.obolibrary.org/obo/OBI_0000963 categorical label http://purl.obolibrary.org/obo/IAO_0000009 datum label A label that is part of a categorical datum and that indicates the value of the data item on the categorical scale. http://purl.obolibrary.org/obo/OBI_0001000 questionnaire http://purl.obolibrary.org/obo/IAO_0000310 document A document with a set of printed or written questions with a choice of answers, devised for the purposes of a survey or statistical study. http://purl.obolibrary.org/obo/OBI_0001468 cell specimen http://purl.obolibrary.org/obo/OBI_0001479 specimen from organism A specimen primarily composed of a cell or cells collected from a multicellular organism or a cell culture. http://purl.obolibrary.org/obo/OBI_0001479 specimen from organism http://purl.obolibrary.org/obo/OBI_0100051 specimen A specimen that derives from an anatomical part or substance arising from an organism. Examples of tissue specimen include tissue, organ, physiological system, blood, or body location (arm). http://purl.obolibrary.org/obo/OBI_0001930 categorical value specification http://purl.obolibrary.org/obo/OBI_0001933 value specification A value specification that is specifies one category out of a fixed number of nominal categories http://purl.obolibrary.org/obo/OBI_0001933 value specification http://purl.obolibrary.org/obo/IAO_0000030 information content entity An information content entity that specifies a value within a classification scheme or on a quantitative scale. http://purl.obolibrary.org/obo/OBI_0002076 collection of specimens http://purl.obolibrary.org/obo/BFO_0000040 material entity A material entity that has two or more specimens as its parts. http://purl.obolibrary.org/obo/OBI_0100051 specimen http://purl.obolibrary.org/obo/BFO_0000040 material entity A material entity that is collected for potential use as an input upon which measurements or observations are performed. http://purl.obolibrary.org/obo/OBI_0200000 data transformation http://purl.obolibrary.org/obo/COB_0000035 completely executed planned process A completely executed planned process that produces output data from input data. http://purl.obolibrary.org/obo/OBI_0200033 leave one out cross validation method http://purl.obolibrary.org/obo/OBI_0000792 statistical model validation is a data transformation : leave-one-out cross-validation (LOOCV) involves using a single observation from the original sample as the validation data, and the remaining observations as the training data. This is repeated such that each observation in the sample is used once as the validation data http://purl.obolibrary.org/obo/OBI_0200041 k-means clustering http://purl.obolibrary.org/obo/OBI_0200175 class discovery data transformation A k-means clustering is a data transformation which achieves a class discovery or partitioning objective, which takes as input a collection of objects (represented as points in multidimensional space) and which partitions them into a specified number k of clusters. The algorithm attempts to find the centers of natural clusters in the data. The most common form of the algorithm starts by partitioning the input points into k initial sets, either at random or using some heuristic data. It then calculates the mean point, or centroid, of each set. It constructs a new partition by associating each point with the closest centroid. Then the centroids are recalculated for the new clusters, and the algorithm repeated by alternate applications of these two steps until convergence, which is obtained when the points no longer switch clusters (or alternatively centroids are no longer changed). http://purl.obolibrary.org/obo/OBI_0200042 hierarchical clustering http://purl.obolibrary.org/obo/OBI_0200175 class discovery data transformation A hierarchical clustering is a data transformation which achieves a class discovery objective, which takes as input data item and builds a hierarchy of clusters. The traditional representation of this hierarchy is a tree (visualized by a dendrogram), with the individual input objects at one end (leaves) and a single cluster containing every object at the other (root). http://purl.obolibrary.org/obo/OBI_0200050 dimensionality reduction http://purl.obolibrary.org/obo/OBI_0200175 class discovery data transformation A dimensionality reduction is data partitioning which transforms each input m-dimensional vector (x_1, x_2, ..., x_m) into an output n-dimensional vector (y_1, y_2, ..., y_n), where n is smaller than m. http://purl.obolibrary.org/obo/OBI_0200051 principal components analysis dimensionality reduction http://purl.obolibrary.org/obo/OBI_0200050 dimensionality reduction A principal components analysis dimensionality reduction is a dimensionality reduction achieved by applying principal components analysis and by keeping low-order principal components and excluding higher-order ones. http://purl.obolibrary.org/obo/OBI_0200111 data visualization http://purl.obolibrary.org/obo/COB_0000035 completely executed planned process A planned process with the objective to graphically represent some data by inputing the data and outputting images, diagrams or animations. http://purl.obolibrary.org/obo/OBI_0200166 data transformation objective http://purl.obolibrary.org/obo/IAO_0000005 objective specification An objective specification to transformation input data into output data http://purl.obolibrary.org/obo/OBI_0200171 partitioning data transformation http://purl.obolibrary.org/obo/OBI_0200000 data transformation A partitioning data transformation is a data transformation that has objective partitioning. http://purl.obolibrary.org/obo/OBI_0200172 partitioning objective http://purl.obolibrary.org/obo/OBI_0200166 data transformation objective A partitioning objective is a data transformation objective where the aim is to generate a collection of disjoint non-empty subsets whose union equals a non-empty input set. http://purl.obolibrary.org/obo/OBI_0200175 class discovery data transformation http://purl.obolibrary.org/obo/OBI_0200000 data transformation A class discovery data transformation (sometimes called unsupervised classification) is a data transformation that has objective class discovery. http://purl.obolibrary.org/obo/OBI_0200178 class discovery objective http://purl.obolibrary.org/obo/OBI_0200166 data transformation objective A class discovery objective (sometimes called unsupervised classification) is a data transformation objective where the aim is to organize input data (typically vectors of attributes) into classes, where the number of classes and their specifications are not known a priori. Depending on usage, the class assignment can be definite or probabilistic. http://purl.obolibrary.org/obo/OBI_0200179 class prediction objective http://purl.obolibrary.org/obo/OBI_0200166 data transformation objective A class prediction objective (sometimes called supervised classification) is a data transformation objective where the aim is to create a predictor from training data through a machine learning technique. The training data consist of pairs of objects (typically vectors of attributes) and class labels for these objects. The resulting predictor can be used to attach class labels to any valid novel input object. Depending on usage, the prediction can be definite or probabilistic. A classification is learned from the training data and can then be tested on test data. http://purl.obolibrary.org/obo/OBI_0200188 cross validation objective http://purl.obolibrary.org/obo/OBI_0200172 partitioning objective A cross validation objective is a data transformation objective in which the aim is to partition a sample of data into subsets such that the analysis is initially performed on a single subset, while the other subset(s) are retained for subsequent use in confirming and validating the initial analysis. http://purl.obolibrary.org/obo/OBI_0200190 clustered data visualization http://purl.obolibrary.org/obo/OBI_0200111 data visualization A data visualization which has input of a clustered data set and produces an output of a report graph which is capable of rendering data of this type. http://purl.obolibrary.org/obo/PR_000000001 protein http://purl.obolibrary.org/obo/PR_000018263 amino acid chain An amino acid chain that is canonically produced de novo by ribosome-mediated translation of a genetically-encoded mRNA, and any derivatives thereof. http://purl.obolibrary.org/obo/CHEBI_33252 atomic nucleus http://purl.obolibrary.org/obo/CHEBI_36342 subatomic particle A nucleus is the positively charged central portion of an atom, excluding the orbital electrons. http://purl.obolibrary.org/obo/CL_0000000 cell http://purl.obolibrary.org/obo/UBERON_0000465 material anatomical entity A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane. http://purl.obolibrary.org/obo/PBPKO_06046 concentration in intestinal tissue http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The concentration of chemical in tissue of intestine. http://purl.obolibrary.org/obo/CHEBI_16670 peptide http://purl.obolibrary.org/obo/CHEBI_33839 macromolecule Amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another with formal loss of water. The term is usually applied to structures formed from α-amino acids, but it includes those derived from any amino carboxylic acid. X = OH, OR, NH2, NHR, etc. http://purl.obolibrary.org/obo/CHEBI_33839 macromolecule http://purl.obolibrary.org/obo/COB_0000013 molecule A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. http://purl.obolibrary.org/obo/CHEBI_36342 subatomic particle http://purl.obolibrary.org/obo/BFO_0000040 material entity A particle smaller than an atom. http://purl.obolibrary.org/obo/GO_0005575 cellular_component http://purl.obolibrary.org/obo/BFO_0000040 material entity A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex). http://purl.obolibrary.org/obo/UBERON_0000465 material anatomical entity http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity Anatomical entity that has mass. http://purl.obolibrary.org/obo/UBERON_0000466 immaterial anatomical entity http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity Anatomical entity that has no mass. http://purl.obolibrary.org/obo/UBERON_0000477 anatomical cluster http://purl.obolibrary.org/obo/UBERON_0000465 material anatomical entity Anatomical group whose component anatomical structures lie in close proximity to each other. http://purl.obolibrary.org/obo/COB_0000011 atom http://purl.obolibrary.org/obo/BFO_0000040 material entity A material entity consisting of exactly one atomic nucleus and the electron(s) orbiting it. http://purl.obolibrary.org/obo/COB_0000013 molecule http://purl.obolibrary.org/obo/BFO_0000040 material entity A material entity that consists of two or more atoms that are all connected via covalent bonds such that any atom can be transitively connected with any other atom. http://purl.obolibrary.org/obo/COB_0000021 gross anatomical part http://purl.obolibrary.org/obo/UBERON_0000465 material anatomical entity A part of a multicellular organism that is a collection of cell components that are not all contained in one cell. http://purl.obolibrary.org/obo/COB_0000022 organism http://purl.obolibrary.org/obo/UBERON_0000465 material anatomical entity A material entity that is a maximal functionally integrated unit that develops from a program encoded in a genome http://purl.obolibrary.org/obo/COB_0000080 complex of molecules http://purl.obolibrary.org/obo/BFO_0000040 material entity A complex of two or more molecules that are not covalently bound. http://purl.obolibrary.org/obo/GO_0003674 gene product or complex activity http://purl.obolibrary.org/obo/BFO_0000015 process A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. http://purl.obolibrary.org/obo/GO_0008150 biological process http://purl.obolibrary.org/obo/BFO_0000015 process A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. http://purl.obolibrary.org/obo/GO_0032991 protein-containing complex http://purl.obolibrary.org/obo/COB_0000080 complex of molecules A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. http://purl.obolibrary.org/obo/GO_0044423 virion component http://purl.obolibrary.org/obo/GO_0005575 cellular_component Any constituent part of a virion, a complete fully infectious extracellular virus particle. http://purl.obolibrary.org/obo/PR_000018263 amino acid chain http://purl.obolibrary.org/obo/COB_0000013 molecule An organic amino compound that consists of amino acid residues (unmodified amino-acid residues and/or modified amino-acid residues) linked by peptide bonds or derivatives of such bonds. http://purl.obolibrary.org/obo/GO_0110165 cellular anatomical entity http://purl.obolibrary.org/obo/UBERON_0000465 material anatomical entity A part of a cellular organism that is either an immaterial entity or a material entity with granularity above the level of a protein complex but below that of an anatomical system. Or, a substance produced by a cellular organism with granularity above the level of a protein complex. http://purl.obolibrary.org/obo/COB_0000082 planned process http://purl.obolibrary.org/obo/BFO_0000015 process A process that is initiated by an agent who intends to carry out a plan to achieve an objective through one or more actions as described in a plan specification. http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_00002 parameter A parameter that is compound-dependent and relates to biological interactions or transformations (e.g., clearance, binding, partition coefficients). http://purl.obolibrary.org/obo/PBPKO_00002 parameter http://purl.obolibrary.org/obo/IAO_0000027 data entity A data item involved in PBPK modelling. http://purl.obolibrary.org/obo/PBPKO_00003 physiologically based pharmacokinetic model http://purl.obolibrary.org/obo/OBI_0000658 data representational model A data representation model that predicts the absorption, distribution, metabolism, and excretion (ADME) of chemical substances in biological species based on physiological principles using mathematical modelling technique. http://purl.obolibrary.org/obo/PBPKO_00004 whole body pbpk http://purl.obolibrary.org/obo/PBPKO_00003 physiologically based pharmacokinetic model A physiologically based pharmacokinetic model that contains an explicit representation of the organs most relevant to the ADME of the compound. http://purl.obolibrary.org/obo/PBPKO_00140 absorption http://purl.obolibrary.org/obo/GO_0008150 biological process A biological process by which a compound moves from its site of administration into the systemic circulation or a target tissue. http://purl.obolibrary.org/obo/PBPKO_00144 enterohepatic recirculation http://purl.obolibrary.org/obo/GO_0008150 biological process A biological process involving recycling of compounds through the liver via biliary excretion, intestinal reabsorption, portal circulation return, and re-excretion. http://purl.obolibrary.org/obo/PBPKO_00146 distribution process http://purl.obolibrary.org/obo/GO_0008150 biological process A biological process describing the movement of a compound from systemic circulation to various organs/tissues. http://purl.obolibrary.org/obo/PBPKO_00322 elimination http://purl.obolibrary.org/obo/GO_0008150 biological process A biological process involving the irreversible removal of a compound from the body, encompassing metabolism and excretion. http://purl.obolibrary.org/obo/PBPKO_00313 endosomal space compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the endosomal space within cells. http://purl.obolibrary.org/obo/PBPKO_00320 central compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment in a multi-compartment model representing plasma and highly perfused tissues where distribution is rapid. http://purl.obolibrary.org/obo/PBPKO_00321 peripheral compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment in a multi-compartment model representing tissues where compound distribution is slower compared to the central compartment. http://purl.obolibrary.org/obo/PBPKO_00402 bladder compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the urinary bladder. http://purl.obolibrary.org/obo/PBPKO_00404 extrathoracic compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the extrathoracic region (head, neck, upper respiratory tract). http://purl.obolibrary.org/obo/PBPKO_00405 thoracic compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the thoracic region (chest). http://purl.obolibrary.org/obo/PBPKO_00450 rest of body compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the lumped remainder of the body not explicitly modeled as separate organs/tissues. http://purl.obolibrary.org/obo/PBPKO_00451 arterial plasma http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the plasma specifically within the arterial blood. http://purl.obolibrary.org/obo/PBPKO_00452 venous plasma compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the plasma specifically within the venous blood. http://purl.obolibrary.org/obo/PBPKO_00453 richly perfused tissue compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing lumped tissues with high blood flow relative to their volume. http://purl.obolibrary.org/obo/PBPKO_00454 poorly perfused tissue compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing lumped tissues with low blood flow relative to their volume. http://purl.obolibrary.org/obo/PBPKO_00460 adipose compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing adipose (fat) tissue. http://purl.obolibrary.org/obo/PBPKO_00464 blood compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the entirety of the blood (including plasma and cells). http://purl.obolibrary.org/obo/PBPKO_00465 bone marrow compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the bone marrow. http://purl.obolibrary.org/obo/PBPKO_00466 brain compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the brain. http://purl.obolibrary.org/obo/PBPKO_00470 skin compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the skin. http://purl.obolibrary.org/obo/PBPKO_00473 endocrine gland compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing endocrine glands. http://purl.obolibrary.org/obo/PBPKO_00479 hair compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing hair. http://purl.obolibrary.org/obo/PBPKO_00480 heart compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the heart. http://purl.obolibrary.org/obo/PBPKO_00483 mammary gland compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the mammary gland. http://purl.obolibrary.org/obo/PBPKO_00484 muscle compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing muscle tissue. http://purl.obolibrary.org/obo/PBPKO_00485 nail compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing nails. http://purl.obolibrary.org/obo/PBPKO_00486 pancreas compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the pancreas. http://purl.obolibrary.org/obo/PBPKO_00488 plasma compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing blood plasma. http://purl.obolibrary.org/obo/PBPKO_00490 reproductive compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing reproductive organs (gonads). http://purl.obolibrary.org/obo/PBPKO_00492 spleen compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the spleen. http://purl.obolibrary.org/obo/PBPKO_00495 barrier compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing a physiological barrier limiting compound movement. http://purl.obolibrary.org/obo/PBPKO_00552 arterial blood compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the arterial blood. http://purl.obolibrary.org/obo/PBPKO_00553 digestive system compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the digestive system or parts thereof. http://purl.obolibrary.org/obo/PBPKO_00554 excreta compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing material eliminated from the body (e.g., urine, feces). http://purl.obolibrary.org/obo/PBPKO_00555 feces compartment http://purl.obolibrary.org/obo/PBPKO_00554 excreta compartment An excreta compartment specifically representing feces. http://purl.obolibrary.org/obo/PBPKO_00556 urine compartment http://purl.obolibrary.org/obo/PBPKO_00554 excreta compartment An excreta compartment specifically representing urine. http://purl.obolibrary.org/obo/PBPKO_00557 kidney compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the kidney(s). http://purl.obolibrary.org/obo/PBPKO_00558 liver compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the liver. http://purl.obolibrary.org/obo/PBPKO_00559 lung compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the lung(s). http://purl.obolibrary.org/obo/PBPKO_00561 venous blood compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the venous blood. http://purl.obolibrary.org/obo/PBPKO_00218 oatp http://purl.obolibrary.org/obo/PBPKO_00217 transporter A transporter family (Organic Anion Transporting Polypeptides) involved in transporting organic anions. http://purl.obolibrary.org/obo/PBPKO_00219 abcc3 http://purl.obolibrary.org/obo/PBPKO_00217 transporter A transporter (ATP-binding cassette subfamily C member 3) involved in bile metabolism and transport. http://purl.obolibrary.org/obo/PBPKO_00220 abcc2 http://purl.obolibrary.org/obo/PBPKO_00217 transporter A transporter (ATP-binding cassette subfamily C member 2) involved in transporting various molecules across cell membranes. http://purl.obolibrary.org/obo/PBPKO_00141 absorption rate constant gut http://purl.obolibrary.org/obo/PBPKO_03075 absorption rate constant An absorption rate constant parameter representing the rate constant for the movement of a compound from the gut to systemic circulation or another compartment. http://purl.obolibrary.org/obo/PBPKO_00142 absorption rate constant intestine http://purl.obolibrary.org/obo/PBPKO_03075 absorption rate constant An absorption rate constant parameter representing the movement of a compound from the intestine to systemic circulation or another compartment. http://purl.obolibrary.org/obo/PBPKO_00143 gastric emptying rate http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter representing the rate at which the stomach empties its contents into the small intestine. http://purl.obolibrary.org/obo/PBPKO_00145 specific intestinal permeability http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter representing the surface area-normalized transcellular permeability of the intestinal wall for a compound. http://purl.obolibrary.org/obo/PBPKO_00147 volume of distribution http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter representing the apparent volume into which a compound distributes in the body relative to its plasma concentration. http://purl.obolibrary.org/obo/PBPKO_00150 fraction unbound gut http://purl.obolibrary.org/obo/PBPKO_00149 unbound fraction An unbound fraction parameter specifically for the gut compartment. http://purl.obolibrary.org/obo/PBPKO_00151 fraction unbound stomach http://purl.obolibrary.org/obo/PBPKO_00149 unbound fraction An unbound fraction parameter specifically for the stomach compartment. http://purl.obolibrary.org/obo/PBPKO_00152 fraction unbound intestine http://purl.obolibrary.org/obo/PBPKO_00149 unbound fraction An unbound fraction parameter specifically for the intestine compartment. http://purl.obolibrary.org/obo/PBPKO_00153 fraction unbound pancreas http://purl.obolibrary.org/obo/PBPKO_00149 unbound fraction An unbound fraction parameter specifically for the pancreas compartment. http://purl.obolibrary.org/obo/PBPKO_00154 fraction unbound liver http://purl.obolibrary.org/obo/PBPKO_00149 unbound fraction An unbound fraction parameter specifically for the liver compartment. http://purl.obolibrary.org/obo/PBPKO_00155 fraction unbound kidney http://purl.obolibrary.org/obo/PBPKO_00149 unbound fraction An unbound fraction parameter specifically for the kidney compartment. http://purl.obolibrary.org/obo/PBPKO_00156 fraction unbound muscle http://purl.obolibrary.org/obo/PBPKO_00149 unbound fraction An unbound fraction parameter specifically for the muscle compartment. http://purl.obolibrary.org/obo/PBPKO_00157 fraction unbound heart http://purl.obolibrary.org/obo/PBPKO_00149 unbound fraction An unbound fraction parameter specifically for the heart compartment. http://purl.obolibrary.org/obo/PBPKO_00158 fraction unbound fat http://purl.obolibrary.org/obo/PBPKO_00149 unbound fraction An unbound fraction parameter specifically for the fat (adipose) compartment. http://purl.obolibrary.org/obo/PBPKO_00159 fraction unbound gonad http://purl.obolibrary.org/obo/PBPKO_00149 unbound fraction An unbound fraction parameter specifically for the gonad compartment. http://purl.obolibrary.org/obo/PBPKO_00160 fraction unbound skin http://purl.obolibrary.org/obo/PBPKO_00149 unbound fraction An unbound fraction parameter specifically for the skin compartment. http://purl.obolibrary.org/obo/PBPKO_00161 fraction unbound bone http://purl.obolibrary.org/obo/PBPKO_00149 unbound fraction An unbound fraction parameter specifically for the bone compartment. http://purl.obolibrary.org/obo/PBPKO_00162 fraction unbound spleen http://purl.obolibrary.org/obo/PBPKO_00149 unbound fraction An unbound fraction parameter specifically for the spleen compartment. http://purl.obolibrary.org/obo/PBPKO_00163 fraction unbound lung http://purl.obolibrary.org/obo/PBPKO_00149 unbound fraction An unbound fraction parameter specifically for the lung compartment. http://purl.obolibrary.org/obo/PBPKO_00164 fraction unbound enterocytes http://purl.obolibrary.org/obo/PBPKO_00149 unbound fraction An unbound fraction parameter specifically within enterocytes. http://purl.obolibrary.org/obo/PBPKO_00166 gut plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in gut to plasma. http://purl.obolibrary.org/obo/PBPKO_00167 stomach plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in stomach to plasma. http://purl.obolibrary.org/obo/PBPKO_00168 intestine plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in intestine to plasma. http://purl.obolibrary.org/obo/PBPKO_00169 pancreas plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in pancreas to plasma. http://purl.obolibrary.org/obo/PBPKO_00170 liver plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in liver to plasma. http://purl.obolibrary.org/obo/PBPKO_00171 kidney plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in kidney to plasma. http://purl.obolibrary.org/obo/PBPKO_00172 muscle plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in muscle to plasma. http://purl.obolibrary.org/obo/PBPKO_00173 heart plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in heart to plasma. http://purl.obolibrary.org/obo/PBPKO_00174 fat plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in fat (adipose tissue) to plasma. http://purl.obolibrary.org/obo/PBPKO_00175 gonad plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in gonads to plasma. http://purl.obolibrary.org/obo/PBPKO_00176 skin plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in skin to plasma. http://purl.obolibrary.org/obo/PBPKO_00177 bone plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in bone to plasma. http://purl.obolibrary.org/obo/PBPKO_00178 spleen plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in spleen to plasma. http://purl.obolibrary.org/obo/PBPKO_00179 lung plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in lung to plasma. http://purl.obolibrary.org/obo/PBPKO_00180 rich perfused plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the lumped richly perfused compartment to plasma. http://purl.obolibrary.org/obo/PBPKO_00181 poor perfused plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the lumped poorly perfused compartment to plasma. http://purl.obolibrary.org/obo/PBPKO_00182 skin stratum corneum partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the stratum corneum to the rest of the skin. http://purl.obolibrary.org/obo/PBPKO_00183 air plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in air to plasma. http://purl.obolibrary.org/obo/PBPKO_00187 blood:plasma ratio http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter representing the ratio of compound concentration in whole blood to that in plasma. http://purl.obolibrary.org/obo/PBPKO_00189 catalytic rate constant http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter quantifying enzymatic reaction velocity (kcat), representing the maximum number of substrate molecules converted per active site per unit time. http://purl.obolibrary.org/obo/PBPKO_00211 maximum rate in intestine http://purl.obolibrary.org/obo/PBPKO_00613 maximum rate A maximum rate (Vmax) of an enzyme catalysed reaction for a compound in the intestine when the enzyme is saturated with substrate. http://purl.obolibrary.org/obo/PBPKO_00212 Michaelis constant intestine http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter Michaelis constant representing the substrate concentration at which the reaction rate in the intestine is half of Vmax (Km). http://purl.obolibrary.org/obo/PBPKO_00213 maximum rate in liver http://purl.obolibrary.org/obo/PBPKO_00613 maximum rate A maximum rate (Vmax) of an enzyme catalysed reaction for a compound in the liver when the enzyme is saturated with substrate. http://purl.obolibrary.org/obo/PBPKO_00214 Michaelis constant liver http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter Michaelis constant representing the substrate concentration at which the reaction rate in the liver is half of Vmax (Km). http://purl.obolibrary.org/obo/PBPKO_00216 dissociation constant http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter (Kd) measuring the affinity of a compound for its binding partner (e.g., receptor, protein). http://purl.obolibrary.org/obo/PBPKO_00221 degradation rate constant http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter (kdeg) representing the rate constant for the degradation of a metabolizing enzyme or transporter. http://purl.obolibrary.org/obo/PBPKO_00222 inhibition constant http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter (Ki) representing the inhibition constant for a specific enzyme or transporter interaction. http://purl.obolibrary.org/obo/PBPKO_00230 fecal clearance rate http://purl.obolibrary.org/obo/PBPKO_00229 clearance rate A clearance rate specifically quantifying elimination via feces. http://purl.obolibrary.org/obo/PBPKO_00231 sweat clearance rate http://purl.obolibrary.org/obo/PBPKO_00229 clearance rate A clearance rate specifically quantifying elimination via sweat. http://purl.obolibrary.org/obo/PBPKO_00232 urinary clearance rate http://purl.obolibrary.org/obo/PBPKO_00229 clearance rate A clearance rate specifically quantifying elimination via urine. http://purl.obolibrary.org/obo/PBPKO_00233 biliary clearance rate http://purl.obolibrary.org/obo/PBPKO_00229 clearance rate A clearance rate specifically quantifying elimination via bile. http://purl.obolibrary.org/obo/PBPKO_00234 hepatic clearance rate http://purl.obolibrary.org/obo/PBPKO_00229 clearance rate A clearance rate specifically quantifying elimination via the liver (metabolism and/or biliary excretion). http://purl.obolibrary.org/obo/PBPKO_00235 intrinsic clearance rate http://purl.obolibrary.org/obo/PBPKO_00229 clearance rate A clearance rate representing the inherent ability of an organ or tissue to eliminate a compound, independent of blood flow or binding. http://purl.obolibrary.org/obo/PBPKO_00236 fecal elimination rate constant http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter representing the rate constant for elimination via fecal excretion. http://purl.obolibrary.org/obo/PBPKO_00237 renal elimination rate constant http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter representing the rate constant for elimination via renal (urinary) excretion. http://purl.obolibrary.org/obo/PBPKO_00304 maximum rate of basolateral transporter in vitro http://purl.obolibrary.org/obo/PBPKO_00613 maximum rate Maximum rate (Vmax) of transport via a basolateral transporter, measured in vitro. http://purl.obolibrary.org/obo/PBPKO_00305 Michaelis constant baso http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter Michaelis constant representing the substrate concentration at half-maximal velocity (Km) for a basolateral transporter. http://purl.obolibrary.org/obo/PBPKO_00306 maximum rate of apical transporter in vitro http://purl.obolibrary.org/obo/PBPKO_00613 maximum rate A maximum rate (Vmax) of an enzyme catalysed reaction for a compound across the apical membrane of an organ, measured in vitro, when the enzyme is saturated with substrate. http://purl.obolibrary.org/obo/PBPKO_00307 Michaelis constant apical http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter Michaelis constant representing the substrate concentration at half-maximal velocity (Km) for an apical transporter. http://purl.obolibrary.org/obo/PBPKO_00310 influx constant http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter (kin) describing the rate constant for compound movement into a cell or compartment. http://purl.obolibrary.org/obo/PBPKO_00311 efflux rate constant http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter (kefflux) describing the rate constant for compound movement out of a cell or compartment. http://purl.obolibrary.org/obo/PBPKO_00315 effective permeability http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter (Peff) representing the rate at which a compound passes through a biological barrier (e.g., intestinal wall). http://purl.obolibrary.org/obo/PBPKO_00363 hippocampus brain partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the hippocampus to the overall brain. http://purl.obolibrary.org/obo/PBPKO_00364 cerebrum brain partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the cerebrum to the overall brain. http://purl.obolibrary.org/obo/PBPKO_00365 cerebellum brain partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the cerebellum to the overall brain. http://purl.obolibrary.org/obo/PBPKO_00366 frontalcortex brain partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the frontal cortex to the overall brain. http://purl.obolibrary.org/obo/PBPKO_00367 apparent permeability cerebrum to rest of brain http://purl.obolibrary.org/obo/PBPKO_00612 apparent permeability Apparent permeability of a compound specifically between the cerebrum and the rest of the brain. http://purl.obolibrary.org/obo/PBPKO_00368 apparent permeability cerebellum to rest of brain http://purl.obolibrary.org/obo/PBPKO_00612 apparent permeability Apparent permeability of a compound specifically between the cerebellum and the rest of the brain. http://purl.obolibrary.org/obo/PBPKO_00369 apparent permeability hippocampus to rest of brain http://purl.obolibrary.org/obo/PBPKO_00612 apparent permeability Apparent permeability of a compound specifically between the hippocampus and the rest of the brain. http://purl.obolibrary.org/obo/PBPKO_00370 apparent permeability cortex to rest of brain http://purl.obolibrary.org/obo/PBPKO_00612 apparent permeability Apparent permeability of a compound specifically between the cortex and the rest of the brain. http://purl.obolibrary.org/obo/PBPKO_00389 maximum rate in fetus http://purl.obolibrary.org/obo/PBPKO_00613 maximum rate A maximum rate (Vmax) of an enzyme catalysed reaction for a compound in fetus when the enzyme is saturated with substrate. http://purl.obolibrary.org/obo/PBPKO_00390 amniotic transfer coefficient http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter representing the rate at which a compound transfers from maternal circulation to amniotic fluid. http://purl.obolibrary.org/obo/PBPKO_00391 liverfetus plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the fetal liver to plasma. http://purl.obolibrary.org/obo/PBPKO_00392 brainfetus plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the fetal brain to plasma. http://purl.obolibrary.org/obo/PBPKO_00393 kidneyfetus plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the fetal kidney to plasma. http://purl.obolibrary.org/obo/PBPKO_00394 restbodyfetus plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the fetal rest of body compartment to plasma. http://purl.obolibrary.org/obo/PBPKO_00429 bile salt effect solubilization ratio http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter representing the ratio of molecules solubilized due to bile salt presence. http://purl.obolibrary.org/obo/PBPKO_00430 mean precipitation time http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter representing the average time for a compound to precipitate under specific conditions (e.g., in the GI tract). http://purl.obolibrary.org/obo/PBPKO_00432 particle density http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical/physical parameter representing the mass per unit volume of particles (e.g., of the administered compound). http://purl.obolibrary.org/obo/PBPKO_00433 particle radius http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical/physical parameter representing the radius of particles (e.g., of the administered compound). http://purl.obolibrary.org/obo/PBPKO_00434 intestinal transit time http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter representing the time required for a compound to move through the intestine. http://purl.obolibrary.org/obo/PBPKO_00436 milk plasma ratio http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter representing the ratio of compound concentration in milk to plasma. http://purl.obolibrary.org/obo/PBPKO_00437 fraction unbound milk http://purl.obolibrary.org/obo/PBPKO_00149 unbound fraction An unbound fraction parameter specifically for milk. http://purl.obolibrary.org/obo/PBPKO_00440 phmilk http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter representing the pH of milk. http://purl.obolibrary.org/obo/PBPKO_00442 milk plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in milk to plasma. http://purl.obolibrary.org/obo/PBPKO_00515 brain plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the brain to plasma. http://purl.obolibrary.org/obo/PBPKO_00517 mammary gland plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the mammary gland to plasma. http://purl.obolibrary.org/obo/PBPKO_00518 restbody plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the rest of body compartment to plasma. http://purl.obolibrary.org/obo/PBPKO_00519 tissue plasma partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in a generic tissue to plasma. http://purl.obolibrary.org/obo/PBPKO_00520 urinary rate constant http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter (rate constant) representing the rate at which a compound is cleared via urine, often scaled by body weight. http://purl.obolibrary.org/obo/PBPKO_00534 urinary rate http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter representing the rate at which a compound is cleared via urine. http://purl.obolibrary.org/obo/PBPKO_00535 resorption maximum http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter (Tm) representing the maximum rate of tubular resorption (e.g., in the kidney). http://purl.obolibrary.org/obo/PBPKO_00536 resorption http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter or process representing the resorption of a compound (e.g., tubular resorption). http://purl.obolibrary.org/obo/PBPKO_00537 octanol air partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient (Koa) representing the ratio of compound concentration in octanol to air at equilibrium. http://purl.obolibrary.org/obo/PBPKO_00127 molecular weight http://purl.obolibrary.org/obo/PBPKO_00126 physicochemical parameter A physicochemical parameter representing the sum of the weights of all atoms in a molecule. http://purl.obolibrary.org/obo/PBPKO_00128 lipophillicity http://purl.obolibrary.org/obo/PBPKO_00126 physicochemical parameter A physicochemical parameter representing the affinity or tendency of a compound to dissolve in lipids or hydrophobic environments. http://purl.obolibrary.org/obo/PBPKO_00129 distribution coefficient http://purl.obolibrary.org/obo/PBPKO_00126 physicochemical parameter A physicochemical parameter representing the logarithm of the ratio of concentrations of a compound in a mixture of two immiscible phases at equilibrium, specifically describing lipophilicity (LogD). http://purl.obolibrary.org/obo/PBPKO_00130 dissolution in two phase system http://purl.obolibrary.org/obo/PBPKO_00126 physicochemical parameter A physicochemical parameter representing the ratio of a dissolved compound in a two-phase system (often used interchangeably with partition coefficient). http://purl.obolibrary.org/obo/PBPKO_00131 logarithmic solubility http://purl.obolibrary.org/obo/PBPKO_00126 physicochemical parameter A physicochemical parameter representing the 10-based logarithm of a compound's solubility (typically in mol/L). http://purl.obolibrary.org/obo/PBPKO_00132 water solubility http://purl.obolibrary.org/obo/PBPKO_00126 physicochemical parameter A physicochemical parameter representing the solubility of a compound specifically in water. http://purl.obolibrary.org/obo/PBPKO_00133 acid dissociation constant http://purl.obolibrary.org/obo/PBPKO_00126 physicochemical parameter A physicochemical parameter representing the negative base-10 logarithm (pKa) of the acid dissociation constant (Ka). http://purl.obolibrary.org/obo/PBPKO_00134 basic dissociation constant http://purl.obolibrary.org/obo/PBPKO_00126 physicochemical parameter A physicochemical parameter representing the negative base-10 logarithm (pKb) of the base dissociation constant (Kb). http://purl.obolibrary.org/obo/PBPKO_00135 physiological charge http://purl.obolibrary.org/obo/PBPKO_00126 physicochemical parameter A physicochemical parameter representing the electrical charge of a molecule at physiological pH. http://purl.obolibrary.org/obo/PBPKO_00136 hydrogen acceptor count http://purl.obolibrary.org/obo/PBPKO_00126 physicochemical parameter A physicochemical parameter representing the integer number of hydrogen bond acceptors in a molecular entity. http://purl.obolibrary.org/obo/PBPKO_00137 hydrogen donor count http://purl.obolibrary.org/obo/PBPKO_00126 physicochemical parameter A physicochemical parameter representing the integer number of hydrogen bond donors in a molecular entity. http://purl.obolibrary.org/obo/PBPKO_00138 rotatable bond count http://purl.obolibrary.org/obo/PBPKO_00126 physicochemical parameter A physicochemical parameter representing the integer count of rotatable bonds in a molecular entity. http://purl.obolibrary.org/obo/PBPKO_00431 diffusion coefficient http://purl.obolibrary.org/obo/PBPKO_00126 physicochemical parameter A physicochemical parameter representing the amount of substance diffusing across a unit area per unit time under a unit concentration gradient. http://purl.obolibrary.org/obo/PBPKO_00007 body mass index http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter A physiological parameter calculated as an individual's weight (kg) divided by the square of their height (m). http://purl.obolibrary.org/obo/PBPKO_00008 bodyweight http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter A physiological parameter representing the mass or quantity of heaviness of an individual. http://purl.obolibrary.org/obo/PBPKO_00009 height http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter A physiological parameter describing the distance from the bottom to the top of someone standing upright. http://purl.obolibrary.org/obo/PBPKO_00010 surface area http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter A physiological parameter representing the total area that the surface of an object occupies. http://purl.obolibrary.org/obo/PBPKO_00011 assigned race http://purl.obolibrary.org/obo/PBPKO_00002 parameter A parameter representing a geographic ancestral origin category assigned to a population group. http://purl.obolibrary.org/obo/PBPKO_00013 cardiac output rate http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter representing the volume of blood pumped by the heart compartment per unit of time. http://purl.obolibrary.org/obo/PBPKO_00014 blood flow rate to stomach http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the stomach compartment. http://purl.obolibrary.org/obo/PBPKO_00015 fraction of blood flow to stomach http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the stomach compartment. http://purl.obolibrary.org/obo/PBPKO_00016 blood flow rate to intestine http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow parameter specifically describing the rate to the intestine compartment. http://purl.obolibrary.org/obo/PBPKO_00017 fraction of blood flow to intestine http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the intestine compartment. http://purl.obolibrary.org/obo/PBPKO_00018 blood flow rate to small intestine http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the small intestine compartment. http://purl.obolibrary.org/obo/PBPKO_00019 fraction of blood flow to small intestine http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the small intestine compartment. http://purl.obolibrary.org/obo/PBPKO_00020 blood flow rate to large intestine http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the large intestine compartment. http://purl.obolibrary.org/obo/PBPKO_00021 fraction of blood flow to large intestine http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the large intestine compartment. http://purl.obolibrary.org/obo/PBPKO_00022 blood flow rate to pancreas http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the pancreas compartment. http://purl.obolibrary.org/obo/PBPKO_00023 fraction of blood flow to pancreas http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the pancreas compartment. http://purl.obolibrary.org/obo/PBPKO_00024 blood flow rate to liver http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the liver compartment. http://purl.obolibrary.org/obo/PBPKO_00025 fraction of blood flow to liver http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the liver compartment. http://purl.obolibrary.org/obo/PBPKO_00026 blood flow rate to kidney http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the kidney compartment. http://purl.obolibrary.org/obo/PBPKO_00027 fraction of blood flow to kidney http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the kidney compartment. http://purl.obolibrary.org/obo/PBPKO_00028 blood flow rate to muscle http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the muscle compartment. http://purl.obolibrary.org/obo/PBPKO_00029 fraction of blood flow to muscle http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the muscle compartment. http://purl.obolibrary.org/obo/PBPKO_00030 blood flow rate to heart http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the heart compartment. http://purl.obolibrary.org/obo/PBPKO_00031 fraction of blood flow to heart http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the heart compartment. http://purl.obolibrary.org/obo/PBPKO_00032 blood flow rate to fat http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the fat (adipose tissue) compartment. http://purl.obolibrary.org/obo/PBPKO_00033 fraction of blood flow to fat http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the fat compartment. http://purl.obolibrary.org/obo/PBPKO_00034 blood flow rate to gonad http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow parameter specifically describing the rate to the gonads compartment. http://purl.obolibrary.org/obo/PBPKO_00035 fraction of blood flow to gonad http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the gonad compartment. http://purl.obolibrary.org/obo/PBPKO_00036 blood flow rate to skin http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the skin compartment. http://purl.obolibrary.org/obo/PBPKO_00037 fraction of blood flow to skin http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the skin compartment. http://purl.obolibrary.org/obo/PBPKO_00038 blood flow rate to bone http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the bone compartment. http://purl.obolibrary.org/obo/PBPKO_00039 fraction of blood flow to bone http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the bone compartment. http://purl.obolibrary.org/obo/PBPKO_00040 blood flow rate to brain http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the brain compartment. http://purl.obolibrary.org/obo/PBPKO_00041 fraction of blood flow to brain http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the brain compartment. http://purl.obolibrary.org/obo/PBPKO_00042 blood flow rate to spleen http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the spleen compartment. http://purl.obolibrary.org/obo/PBPKO_00043 fraction of blood flow to spleen http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the spleen compartment. http://purl.obolibrary.org/obo/PBPKO_00044 blood flow rate to lung http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the lung compartment. http://purl.obolibrary.org/obo/PBPKO_00045 fraction of blood flow to lung http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the lung compartment. http://purl.obolibrary.org/obo/PBPKO_00046 blood flow rate to poorly perfused http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the poorly perfused organ/tissue compartment. http://purl.obolibrary.org/obo/PBPKO_00047 fraction of blood flow to poorly perfused http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the poorly perfused compartment. http://purl.obolibrary.org/obo/PBPKO_00048 blood flow rate to richly perfused http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the richly perfused organ/tissue compartment. http://purl.obolibrary.org/obo/PBPKO_00049 fraction of blood flow to richly perfused http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the richly perfused compartment. http://purl.obolibrary.org/obo/PBPKO_00050 blood flow rate to restbody http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the rest of body compartment (total minus specified organs). http://purl.obolibrary.org/obo/PBPKO_00051 fraction of blood flow to restbody http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the rest of the body compartment. http://purl.obolibrary.org/obo/PBPKO_00052 blood flow rate to gall bladder http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the gall bladder compartment. http://purl.obolibrary.org/obo/PBPKO_00053 fraction of blood flow to gall bladder http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the gall bladder compartment. http://purl.obolibrary.org/obo/PBPKO_00054 blood flow rate to portal vein http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the portal vein compartment. http://purl.obolibrary.org/obo/PBPKO_00055 fraction of blood flow to portal vein http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the portal vein compartment. http://purl.obolibrary.org/obo/PBPKO_00056 blood flow rate to lymph http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the lymph compartment. http://purl.obolibrary.org/obo/PBPKO_00057 fraction of blood flow to lymph http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the lymph compartment. http://purl.obolibrary.org/obo/PBPKO_00058 amount of metabolized http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter representing the total amount of compound metabolized. http://purl.obolibrary.org/obo/PBPKO_00060 fraction of blood flow to stratum corneum http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the stratum corneum compartment. http://purl.obolibrary.org/obo/PBPKO_00061 fraction of exposed skin http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the exposed skin volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00062 fraction of unexposed skin http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the unexposed skin volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00063 arterial blood flow rate http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter representing the rate of blood flow through the arterial compartment. http://purl.obolibrary.org/obo/PBPKO_00064 venous blood flow rate http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter representing the rate of blood flow returning through the venous compartment. http://purl.obolibrary.org/obo/PBPKO_00065 glomerular filtration rate http://purl.obolibrary.org/obo/PBPKO_00636 bodily fluid flow rate parameter A bodily fluid flow rate parameter (or physiological process measure) describing the flow rate of filtered fluid through the kidney compartment. http://purl.obolibrary.org/obo/PBPKO_00067 volume of stomach http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the stomach compartment. http://purl.obolibrary.org/obo/PBPKO_00068 fraction of stomach http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the stomach volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00069 volume of intestine http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the intestine compartment. http://purl.obolibrary.org/obo/PBPKO_00070 fraction of intestine http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the intestine volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00071 volume of small intestine http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the small intestine compartment. http://purl.obolibrary.org/obo/PBPKO_00072 fraction of small intestine http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the small intestine volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00073 volume of large intestine http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the large intestine compartment. http://purl.obolibrary.org/obo/PBPKO_00074 fraction of large intestine http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the large intestine volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00075 volume of pancreas http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the pancreas compartment. http://purl.obolibrary.org/obo/PBPKO_00076 fraction of pancreas http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the pancreas volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00077 volume of liver http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the liver compartment. http://purl.obolibrary.org/obo/PBPKO_00078 fraction of liver http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the liver volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00079 volume of kidney http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the kidney compartment. http://purl.obolibrary.org/obo/PBPKO_00080 fraction of kidney http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the kidney volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00081 volume of muscle http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of muscle compartment. http://purl.obolibrary.org/obo/PBPKO_00082 fraction of muscle http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the muscle volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00083 volume of heart http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the heart compartment. http://purl.obolibrary.org/obo/PBPKO_00084 fraction of heart http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the heart volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00085 volume of fat http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of fat (adipose tissue) compartment. http://purl.obolibrary.org/obo/PBPKO_00086 fraction of fat http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the fat volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00087 volume of gonad http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the gonad compartment. http://purl.obolibrary.org/obo/PBPKO_00088 fraction of gonad http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the gonad volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00089 volume of skin http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the skin compartment. http://purl.obolibrary.org/obo/PBPKO_00090 fraction of skin http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the skin volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00091 volume of bone http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of bone compartment. http://purl.obolibrary.org/obo/PBPKO_00092 fraction of bone http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the bone volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00093 volume of brain http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the brain compartment. http://purl.obolibrary.org/obo/PBPKO_00094 fraction of brain http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the brain volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00095 volume of spleen http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the spleen compartment. http://purl.obolibrary.org/obo/PBPKO_00096 fraction of spleen http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the spleen volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00097 volume of lung http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the lung compartment. http://purl.obolibrary.org/obo/PBPKO_00098 fraction of lung http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the lung volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00099 volume of poorly perfused http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the poorly perfused compartment. http://purl.obolibrary.org/obo/PBPKO_00100 fraction of poorly perfused http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the poorly perfused compartment volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00101 volume of richly perfused http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the richly perfused compartment. http://purl.obolibrary.org/obo/PBPKO_00102 fraction of richly perfused http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the richly perfused compartment volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00103 volume of plasma http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of plasma compartment. http://purl.obolibrary.org/obo/PBPKO_00104 fraction of plasma http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the plasma volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00105 volume of rest body http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the rest of body compartment. http://purl.obolibrary.org/obo/PBPKO_00106 fraction of rest body http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the rest of body volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00107 volume of stratum corneum with respect to blood http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of stratum corneum compartment with respect to blood/plasma. http://purl.obolibrary.org/obo/PBPKO_00108 volume of blood http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of blood compartment. http://purl.obolibrary.org/obo/PBPKO_00109 volume of exposed skin http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the exposed skin compartment. http://purl.obolibrary.org/obo/PBPKO_00111 volume of unexposed skin http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the unexposed skin compartment. http://purl.obolibrary.org/obo/PBPKO_00112 volume of stratum corneum exposed http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the exposed stratum corneum compartment. http://purl.obolibrary.org/obo/PBPKO_00113 volume of unexposed stratum corneum http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the unexposed stratum corneum compartment. http://purl.obolibrary.org/obo/PBPKO_00114 fraction alveolar volume http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the alveolar volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00115 volume of gall bladder http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the gall bladder compartment. http://purl.obolibrary.org/obo/PBPKO_00116 fraction of gall bladder http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the gall bladder volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00117 volume of portal vein http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the portal vein compartment. http://purl.obolibrary.org/obo/PBPKO_00118 fraction of portal vein http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the portal vein volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00119 volume of lymph http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of lymph compartment. http://purl.obolibrary.org/obo/PBPKO_00120 fraction of lymph http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the lymph volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00121 arterial volume http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the arterial compartment. http://purl.obolibrary.org/obo/PBPKO_00122 venous volume http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the venous compartment. http://purl.obolibrary.org/obo/PBPKO_00296 reference human data set http://purl.obolibrary.org/obo/IAO_0000100 homogenous data collection A data set containing the physiological parameters representing a standard human, often defined by specific characteristics like 70 kg body weight. http://purl.obolibrary.org/obo/PBPKO_00312 plasma space http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter A physiological parameter representing the volume occupied by plasma within a tissue or the body. http://purl.obolibrary.org/obo/PBPKO_00314 interstitial space http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter A physiological parameter representing the fluid-filled space between blood vessels and cells. http://purl.obolibrary.org/obo/PBPKO_00333 fetus lifestage http://purl.obolibrary.org/obo/PBPKO_00332 lifestage A lifestage parameter representing the unborn offspring from the postembryonic stage until birth. http://purl.obolibrary.org/obo/PBPKO_00334 infant lifestage http://purl.obolibrary.org/obo/PBPKO_00332 lifestage A lifestage parameter representing a very young child, typically under one year of age. http://purl.obolibrary.org/obo/PBPKO_00335 toddler lifestage http://purl.obolibrary.org/obo/PBPKO_00332 lifestage A lifestage parameter representing a young child, typically between one and three years old. http://purl.obolibrary.org/obo/PBPKO_00336 child lifestage http://purl.obolibrary.org/obo/PBPKO_00332 lifestage A lifestage parameter representing individuals typically between 3 and 11 years old. http://purl.obolibrary.org/obo/PBPKO_00337 teenager lifestage http://purl.obolibrary.org/obo/PBPKO_00332 lifestage A lifestage parameter representing individuals typically between eleven and fifteen years old. http://purl.obolibrary.org/obo/PBPKO_00338 adolescent lifestage http://purl.obolibrary.org/obo/PBPKO_00332 lifestage A lifestage parameter representing the transitional stage between teenager and adulthood (approx. 15-18 years). http://purl.obolibrary.org/obo/PBPKO_00339 adult lifestage http://purl.obolibrary.org/obo/PBPKO_00332 lifestage A lifestage parameter representing individuals typically from eighteen to thirty years old. http://purl.obolibrary.org/obo/PBPKO_00340 middle age lifestage http://purl.obolibrary.org/obo/PBPKO_00332 lifestage A lifestage parameter representing individuals typically from thirty to forty-five years old. http://purl.obolibrary.org/obo/PBPKO_00341 old age lifestage http://purl.obolibrary.org/obo/PBPKO_00332 lifestage A lifestage parameter representing individuals typically from forty-five to sixty years old (or older, definitions vary). http://purl.obolibrary.org/obo/PBPKO_00342 pediatric lifestage http://purl.obolibrary.org/obo/PBPKO_00332 lifestage A lifestage parameter representing individuals typically below fifteen years of age. http://purl.obolibrary.org/obo/PBPKO_00343 geriatric lifestage http://purl.obolibrary.org/obo/PBPKO_00332 lifestage A lifestage parameter representing older adults, often considered 60/65 years and older. http://purl.obolibrary.org/obo/PBPKO_00348 cerebrospinal fluid volume http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of cerebrospinal fluid (CSF) compartment in the spinal region. http://purl.obolibrary.org/obo/PBPKO_00349 cranial cerebrospinal fluid volume http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of cerebrospinal fluid (CSF) compartment in the cranial region. http://purl.obolibrary.org/obo/PBPKO_00350 brain mass http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter A physiological parameter representing the mass of the brain. http://purl.obolibrary.org/obo/PBPKO_00352 spinal cerebrospinal fluid flow rate http://purl.obolibrary.org/obo/PBPKO_00636 bodily fluid flow rate parameter A bodily fluid flow rate parameter representing the flow rate of cerebrospinal fluid (CSF) compartment in the spinal region. http://purl.obolibrary.org/obo/PBPKO_00353 cranial cerebrospinal fluid flow rate http://purl.obolibrary.org/obo/PBPKO_00636 bodily fluid flow rate parameter A bodily fluid flow rate parameter representing the flow rate of cerebrospinal fluid (CSF) compartment in the cranial region. http://purl.obolibrary.org/obo/PBPKO_00355 volume of hippocampus http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the hippocampus compartment. http://purl.obolibrary.org/obo/PBPKO_00356 volume of frontal cortex http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the frontal cortex compartment. http://purl.obolibrary.org/obo/PBPKO_00357 volume of cerebrum http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the cerebrum compartment. http://purl.obolibrary.org/obo/PBPKO_00358 volume of cerebellum http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the cerebellum compartment. http://purl.obolibrary.org/obo/PBPKO_00359 blood flow rate to hippocampus http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the hippocampus compartment. http://purl.obolibrary.org/obo/PBPKO_00360 blood flow rate to frontal cortex http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the frontal cortex compartment. http://purl.obolibrary.org/obo/PBPKO_00361 blood flow rate to cerebrum http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the cerebrum compartment. http://purl.obolibrary.org/obo/PBPKO_00362 blood flow rate to cerebellum http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the cerebellum compartment. http://purl.obolibrary.org/obo/PBPKO_00372 fetoplacental volume http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the placental compartment for fetus. http://purl.obolibrary.org/obo/PBPKO_00373 volume of fetus http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the fetus. http://purl.obolibrary.org/obo/PBPKO_00374 volume of placenta http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the placental compartment. http://purl.obolibrary.org/obo/PBPKO_00375 volume of amniotic fluid http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the amniotic fluid compartment. http://purl.obolibrary.org/obo/PBPKO_00376 volume of liver fetus http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the fetal liver compartment. http://purl.obolibrary.org/obo/PBPKO_00377 volume of brain fetus http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the fetal brain compartment. http://purl.obolibrary.org/obo/PBPKO_00378 volume of kidney fetus http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the fetal kidney compartment. http://purl.obolibrary.org/obo/PBPKO_00379 volume of rest body fetus http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the rest of body compartment within the fetus. http://purl.obolibrary.org/obo/PBPKO_00381 fetoplacental blood flow rate http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter representing the rate of blood flow between the fetus and the placenta compartment. http://purl.obolibrary.org/obo/PBPKO_00382 fetal cardiac output rate http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter representing the volume of blood pumped by the fetal heart compartment per unit time. http://purl.obolibrary.org/obo/PBPKO_00383 blood flow rate to liverfetus http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the fetal liver compartment. http://purl.obolibrary.org/obo/PBPKO_00384 blood flow rate to kidneyfetus http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the fetal kidney compartment. http://purl.obolibrary.org/obo/PBPKO_00385 blood flow rate to brain fetus http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the fetal brain compartment. http://purl.obolibrary.org/obo/PBPKO_00386 blood flow rate to restbody fetus http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the rest of body compartment within the fetus. http://purl.obolibrary.org/obo/PBPKO_00387 gestational age http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter A physiological parameter representing the age of a pregnancy, typically measured in weeks. http://purl.obolibrary.org/obo/PBPKO_00388 gestational week http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter A physiological parameter representing the specific week of gestation. http://purl.obolibrary.org/obo/PBPKO_00409 fraction of blood flow to duodenum http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the duodenum compartment. http://purl.obolibrary.org/obo/PBPKO_00410 fraction of blood flow to jejunum http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the jejunum compartment. http://purl.obolibrary.org/obo/PBPKO_00411 fraction of blood flow to ileum http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the ileum compartment. http://purl.obolibrary.org/obo/PBPKO_00412 fraction of blood flow to colon http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the colon compartment. http://purl.obolibrary.org/obo/PBPKO_00413 fraction of blood flow to cecum http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the cecum compartment. http://purl.obolibrary.org/obo/PBPKO_00414 blood flow rate to duodenum http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the duodenum compartment. http://purl.obolibrary.org/obo/PBPKO_00415 blood flow rate to jejunum http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the jejunum compartment. http://purl.obolibrary.org/obo/PBPKO_00416 blood flow rate to ileum http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the ileum compartment. http://purl.obolibrary.org/obo/PBPKO_00417 blood flow rate to colon http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the colon compartment. http://purl.obolibrary.org/obo/PBPKO_00418 blood flow rate to cecum http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the cecum compartment. http://purl.obolibrary.org/obo/PBPKO_00419 fraction of duodenum http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the duodenum volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00420 fraction of jejunum http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the jejunum volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00421 fraction of ileum http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the ileum volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00422 fraction of colon http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the colon volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00423 fraction of cecum http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the cecum volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00424 volume of duodenum http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the duodenum compartment. http://purl.obolibrary.org/obo/PBPKO_00425 volume of jejunum http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the jejunum compartment. http://purl.obolibrary.org/obo/PBPKO_00426 volume of ileum http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the ileum compartment. http://purl.obolibrary.org/obo/PBPKO_00427 volume of colon http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the colon compartment. http://purl.obolibrary.org/obo/PBPKO_00428 volume of cecum http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the cecum compartment. http://purl.obolibrary.org/obo/PBPKO_00439 daily milk intake http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter A physiological parameter representing the daily volume of milk ingested (e.g., by an infant). http://purl.obolibrary.org/obo/PBPKO_00508 fraction of filtrate http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the filtrate volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00509 fraction of gut http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the gut volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00510 fraction of mammary gland http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the mammary gland volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00511 fraction of blood flow to filtrate http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the filtrate compartment. http://purl.obolibrary.org/obo/PBPKO_00512 fraction of blood flow to bone marrow http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the bone marrow compartment. http://purl.obolibrary.org/obo/PBPKO_00513 fraction of blood flow to gut http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the gut compartment. http://purl.obolibrary.org/obo/PBPKO_00514 fraction of blood flow to mammary gland http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment The dimensionless fraction of cardiac output delivered to the mammary gland compartment. http://purl.obolibrary.org/obo/PBPKO_00521 age in PBPK model http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter A physiological parameter representing the period of lifespan (typically in years) for which the model is simulated. http://purl.obolibrary.org/obo/PBPKO_00522 volume of filtrate http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the filtrate compartment. http://purl.obolibrary.org/obo/PBPKO_00523 volume of bone marrow http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the bone marrow compartment. http://purl.obolibrary.org/obo/PBPKO_00524 volume of gut http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the gut compartment. http://purl.obolibrary.org/obo/PBPKO_00525 volume of mammary gland http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the mammary gland compartment. http://purl.obolibrary.org/obo/PBPKO_00526 volume of mass balance http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the check for total mass balance of all compartments (sum of organ volumes should equal body volume/weight equivalent, depending on units). http://purl.obolibrary.org/obo/PBPKO_00527 hematocrit volume http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of red blood cells in whole blood. http://purl.obolibrary.org/obo/PBPKO_00528 cardiac output rate of plasma http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter representing the cardiac output specifically related to plasma flow. http://purl.obolibrary.org/obo/PBPKO_00529 blood flow rate to filtrate http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the filtrate compartment (representing glomerular filtration). http://purl.obolibrary.org/obo/PBPKO_00530 blood flow rate to bone marrow http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow parameter specifically describing the rate to the bone marrow compartment. http://purl.obolibrary.org/obo/PBPKO_00531 blood flow rate to gut http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the gut compartment. http://purl.obolibrary.org/obo/PBPKO_00532 blood flow rate to mammary gland http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter specifically describing the rate to the mammary gland compartment. http://purl.obolibrary.org/obo/PBPKO_00533 blood flow rate for mass balance http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment A blood flow rate parameter representing the check for total blood flow mass balance of all the compartments (sum of organ flows should equal cardiac output). http://purl.obolibrary.org/obo/PBPKO_00240 oral exposure http://purl.obolibrary.org/obo/PBPKO_00239 route of exposure A route of exposure via the mouth. http://purl.obolibrary.org/obo/PBPKO_00241 dermal exposure http://purl.obolibrary.org/obo/PBPKO_00239 route of exposure A route of exposure via the skin. http://purl.obolibrary.org/obo/PBPKO_00242 inhalation exposure http://purl.obolibrary.org/obo/PBPKO_00239 route of exposure A route of exposure via inhalation into the lungs. http://purl.obolibrary.org/obo/PBPKO_00243 intravenous bolus exposure http://purl.obolibrary.org/obo/PBPKO_00239 route of exposure A route of exposure involving rapid injection directly into a vein. http://purl.obolibrary.org/obo/PBPKO_00244 intravenous infusion exposure http://purl.obolibrary.org/obo/PBPKO_00239 route of exposure A route of exposure involving continuous administration directly into a vein over time. http://purl.obolibrary.org/obo/PBPKO_00245 intramuscular exposure http://purl.obolibrary.org/obo/PBPKO_00239 route of exposure A route of exposure involving injection into a muscle. http://purl.obolibrary.org/obo/PBPKO_00246 intraarterial exposure http://purl.obolibrary.org/obo/PBPKO_00239 route of exposure A route of exposure involving administration directly into an artery. http://purl.obolibrary.org/obo/PBPKO_00247 intrathecal exposure http://purl.obolibrary.org/obo/PBPKO_00239 route of exposure A route of exposure involving administration into the spinal canal. http://purl.obolibrary.org/obo/PBPKO_00248 subcutaneous exposure http://purl.obolibrary.org/obo/PBPKO_00239 route of exposure A route of exposure involving administration under the skin. http://purl.obolibrary.org/obo/PBPKO_00249 nasal exposure http://purl.obolibrary.org/obo/PBPKO_00239 route of exposure A route of exposure via the nasal passages. http://purl.obolibrary.org/obo/PBPKO_00250 transdermal exposure http://purl.obolibrary.org/obo/PBPKO_00239 route of exposure A route of exposure involving absorption through the skin, typically from a patch. http://purl.obolibrary.org/obo/PBPKO_00251 ocular exposure http://purl.obolibrary.org/obo/PBPKO_00239 route of exposure A route of exposure via the eye. http://purl.obolibrary.org/obo/PBPKO_00005 perfusion limited model http://purl.obolibrary.org/obo/PBPKO_00003 physiologically based pharmacokinetic model A physiologically based pharmacokinetic model that assumes tissue concentration reaches equilibrium rapidly and uptake/elimination is limited by blood flow rate. http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter http://purl.obolibrary.org/obo/PBPKO_00002 parameter A parameter that provides the structural framework for a PBPK model and relates to the organism's physiology (e.g., body weight, organ volume, blood flow). http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment http://purl.obolibrary.org/obo/PBPKO_00636 bodily fluid flow rate parameter A bodily fluid flow rate parameter representing the rate of blood flow in different parts of the body http://purl.obolibrary.org/obo/PBPKO_00636 bodily fluid flow rate parameter http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter A physiological parameter representing the rate of fluid flow to a particular compartment. http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter A physiological parameter representing dimensionless fraction of cardiac output delivered to a compartment. http://purl.obolibrary.org/obo/PBPKO_00252 output parameter http://purl.obolibrary.org/obo/PBPKO_00002 parameter A parameter representing a result or prediction generated by the PBPK model. http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter A physiological parameter representing the dimensionless fraction computed by dividing the volume of the compartment by the total body weight. http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter A physiological parameter representing the volume of a specific organ or tissue. http://purl.obolibrary.org/obo/PBPKO_00110 fraction of surface area exposed http://purl.obolibrary.org/obo/PBPKO_00010 surface area A surface area parameter representing the fraction of skin surface area actually exposed. http://purl.obolibrary.org/obo/PBPKO_00126 physicochemical parameter http://purl.obolibrary.org/obo/PBPKO_00002 parameter A parameter relating to the physical and chemical properties of a compound (e.g., MW, lipophilicity, solubility, pKa). http://purl.obolibrary.org/obo/PBPKO_00148 protein binding mediated distributiion process http://purl.obolibrary.org/obo/PBPKO_00146 distribution process A distribution process (or molecular function) where substances bind to proteins or related compounds. http://purl.obolibrary.org/obo/PBPKO_00149 unbound fraction http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter representing the fraction of a compound that is not bound (e.g., to proteins). http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter representing the ratio of the concentration of a compound in a particular tissue to its concentration in plasma/blood at equilibrium. http://purl.obolibrary.org/obo/PBPKO_00184 skin diffusion coefficient http://purl.obolibrary.org/obo/PBPKO_00431 diffusion coefficient A diffusion coefficient representing the diffusion of a compound across the skin. http://purl.obolibrary.org/obo/PBPKO_00185 human serum albumin http://purl.obolibrary.org/obo/BFO_0000040 material entity A material entity representing distribution-related protein (most abundant in human plasma) that binds various compounds. http://purl.obolibrary.org/obo/PBPKO_00191 phase I metabolism http://purl.obolibrary.org/obo/GO_0008152 metabolic process A metabolism process involving the conversion of exogenous substances to more polar metabolites, often via oxidation, reduction, or hydrolysis (e.g., by CYPs). http://purl.obolibrary.org/obo/PBPKO_00200 phase II http://purl.obolibrary.org/obo/GO_0008152 metabolic process A metabolism process involving the conjugation of phase I products (or parent compounds) to hydrophilic moieties to facilitate excretion. http://purl.obolibrary.org/obo/PBPKO_00209 phase III http://purl.obolibrary.org/obo/GO_0008152 metabolic process A metabolism/transport process involving the further processing and excretion of conjugated metabolites (often involving efflux transporters). http://purl.obolibrary.org/obo/PBPKO_00210 first pass metabolism http://purl.obolibrary.org/obo/GO_0008152 metabolic process A metabolism process occurring at a specific location (e.g., liver, gut wall) after administration but before reaching systemic circulation, reducing the concentration of active compound. http://purl.obolibrary.org/obo/PBPKO_00613 maximum rate http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter representing Vmax of the enzymatic activity http://purl.obolibrary.org/obo/PBPKO_00215 gut metabolism http://purl.obolibrary.org/obo/GO_0008152 metabolic process A metabolism process specifically occurring within the gut. http://purl.obolibrary.org/obo/PBPKO_00217 transporter http://purl.obolibrary.org/obo/BFO_0000040 material entity A material entity representing protein responsible for the import or export of compounds across cell membranes. http://purl.obolibrary.org/obo/PBPKO_00223 renal excretion http://purl.obolibrary.org/obo/GO_0007588 excretion An excretion process involving the elimination of compounds and metabolites primarily through urine via the kidneys. http://purl.obolibrary.org/obo/PBPKO_00224 hepatic excretion http://purl.obolibrary.org/obo/GO_0007588 excretion An excretion process involving the elimination of compounds and metabolites via the liver (often into bile). http://purl.obolibrary.org/obo/PBPKO_00225 fecal excretion http://purl.obolibrary.org/obo/GO_0007588 excretion An excretion process involving the elimination of compounds and metabolites through feces. http://purl.obolibrary.org/obo/PBPKO_00226 exhalation http://purl.obolibrary.org/obo/GO_0007588 excretion An excretion process involving the elimination of volatile compounds and metabolites through respiration. http://purl.obolibrary.org/obo/PBPKO_00227 sweat excretion http://purl.obolibrary.org/obo/GO_0007588 excretion An excretion process involving the elimination of compounds and metabolites through sweat. http://purl.obolibrary.org/obo/PBPKO_00228 hair excretion http://purl.obolibrary.org/obo/GO_0007588 excretion An excretion process involving the elimination and deposition of compounds and metabolites into hair. http://purl.obolibrary.org/obo/PBPKO_00229 clearance rate http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter representing the volume of biological fluid cleared of a compound per unit time. http://purl.obolibrary.org/obo/PBPKO_00238 biliary elimination http://purl.obolibrary.org/obo/PBPKO_00322 elimination An elimination process involving the irreversible transfer of compound or metabolites from plasma to bile via hepatocytes. http://purl.obolibrary.org/obo/PBPKO_00239 route of exposure http://purl.obolibrary.org/obo/PBPKO_00002 parameter A parameter designating the body part or method through which exposure is introduced. http://purl.obolibrary.org/obo/PBPKO_00253 peak concentration http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter representing the highest concentration (Cmax) of a compound achieved after exposure. http://purl.obolibrary.org/obo/PBPKO_00254 maximum steady state concentration http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter representing the maximum concentration (Cmax,ss) achieved at steady state during repeated dosing. http://purl.obolibrary.org/obo/PBPKO_00255 maximum time http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter representing the time (Tmax) required to reach the peak concentration. http://purl.obolibrary.org/obo/PBPKO_00256 area under curve http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter representing the integral of the concentration-time curve (AUC), indicating total exposure. http://purl.obolibrary.org/obo/PBPKO_00257 area under curve 0 to t http://purl.obolibrary.org/obo/PBPKO_00256 area under curve An area under curve parameter calculated from time zero to a specific time point t (AUC0-t). http://purl.obolibrary.org/obo/PBPKO_00258 area under curve last http://purl.obolibrary.org/obo/PBPKO_00256 area under curve An area under curve parameter calculated from time zero to the time of the last measurable concentration (AUClast). http://purl.obolibrary.org/obo/PBPKO_00259 area under curve 0 to infinity http://purl.obolibrary.org/obo/PBPKO_00256 area under curve An area under curve parameter extrapolated from time zero to infinity (AUC0-inf), representing total exposure after a single dose. http://purl.obolibrary.org/obo/PBPKO_00260 area under moment curve http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter calculated as the integral of the product of time and concentration versus time (AUMC). http://purl.obolibrary.org/obo/PBPKO_00261 mean residence time http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter representing the average time a compound resides in the body (MRT). http://purl.obolibrary.org/obo/PBPKO_00262 half-life http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter representing the time required for the compound concentration to decrease by half (t1/2). http://purl.obolibrary.org/obo/PBPKO_00263 bioavailability http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter representing the rate and extent to which an active compound is absorbed and becomes available at the site of action or systemic circulation. http://purl.obolibrary.org/obo/PBPKO_00264 relative bioavailability http://purl.obolibrary.org/obo/PBPKO_00263 bioavailability A bioavailability parameter comparing the rate and extent of absorption of a test compound to a reference compound. http://purl.obolibrary.org/obo/PBPKO_00265 mean absorption time http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter representing the average time for a compound to be absorbed into systemic circulation (MAT). http://purl.obolibrary.org/obo/PBPKO_00266 mean dissolution time http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter representing the average time for a compound to dissolve in the body (MDT). http://purl.obolibrary.org/obo/PBPKO_00267 bioequivalence http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter indicating comparable bioavailability between test and reference formulations under similar conditions. http://purl.obolibrary.org/obo/PBPKO_00268 absolute bioavailability http://purl.obolibrary.org/obo/PBPKO_00263 bioavailability A bioavailability parameter comparing the amount reaching systemic circulation after non-IV administration to the amount available after IV administration. http://purl.obolibrary.org/obo/PBPKO_00269 elimination phase http://purl.obolibrary.org/obo/PBPKO_00322 elimination An elimination process phase describing the period where removal of the compound from the body predominates. http://purl.obolibrary.org/obo/PBPKO_00270 absorption phase http://purl.obolibrary.org/obo/PBPKO_00140 absorption An absorption process phase describing the period where the compound moves from the administration site into systemic circulation. http://purl.obolibrary.org/obo/PBPKO_00272 amount in urine http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the urine compartment. http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter representing the amount of chemical specifically in the compartment http://purl.obolibrary.org/obo/PBPKO_00273 amount in feces http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the feces compartment. http://purl.obolibrary.org/obo/PBPKO_00274 cumulative amount in urine http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter representing the total amount of compound excreted in urine over a specific time period. http://purl.obolibrary.org/obo/PBPKO_00275 cumulative amount in feces http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter representing the total amount of compound excreted in feces over a specific time period. http://purl.obolibrary.org/obo/PBPKO_00277 steady state area under curve http://purl.obolibrary.org/obo/PBPKO_00256 area under curve An area under curve parameter calculated over a dosing interval at steady state (AUCss). http://purl.obolibrary.org/obo/PBPKO_00279 min organ concentration http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter representing the minimum concentration of a compound in a specific organ after exposure. http://purl.obolibrary.org/obo/PBPKO_00280 max organ concentration http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter representing the maximum concentration of a compound in a specific organ after exposure. http://purl.obolibrary.org/obo/PBPKO_00281 median organ concentration http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter representing the median concentration of a compound in a specific organ after exposure. http://purl.obolibrary.org/obo/PBPKO_00282 percentile 2.5 cplasma http://purl.obolibrary.org/obo/PBPKO_00549 concentration in plasma A plasma concentration parameter representing the 2.5th percentile of the plasma concentration distribution in a population simulation. http://purl.obolibrary.org/obo/PBPKO_00549 concentration in plasma http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The total concentration of compound in the plasma compartment. http://purl.obolibrary.org/obo/PBPKO_00283 percentile 97.5 cplasma http://purl.obolibrary.org/obo/PBPKO_00549 concentration in plasma A plasma concentration parameter representing the 97.5th percentile of the plasma concentration distribution in a population simulation. http://purl.obolibrary.org/obo/PBPKO_00284 tolerable daily intake http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter (or exposure limit) estimating the amount of a substance that can be ingested daily over a lifetime without appreciable health risk (TDI). http://purl.obolibrary.org/obo/PBPKO_00285 reconstructed exposure http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter estimating the amount of compound exposure based on internal body measurements. http://purl.obolibrary.org/obo/PBPKO_00286 estimated daily intake http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter estimating the amount of a compound consumed daily (EDI). http://purl.obolibrary.org/obo/PBPKO_00287 biomonitoring equivalent http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter representing the concentration of a chemical (or metabolite) in a biological medium consistent with exposure guidance values (BE). http://purl.obolibrary.org/obo/PBPKO_00289 reference dose http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter (or exposure limit) estimating the daily oral or dermal exposure likely to be without appreciable risk over a lifetime (RfD). http://purl.obolibrary.org/obo/PBPKO_00290 acceptable daily intake http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter (or exposure limit) estimating the amount of a substance in food/water that can be consumed daily without appreciable health risk (ADI). http://purl.obolibrary.org/obo/PBPKO_00297 biological matrix concentration http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter representing the total concentration of a compound in a specified biological matrix. http://purl.obolibrary.org/obo/PBPKO_00298 concentration in hair http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The total concentration of compound in the hair compartment. http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment http://purl.obolibrary.org/obo/PBPKO_00252 output parameter An output parameter representing the total concentration of compound in the compartment. http://purl.obolibrary.org/obo/PBPKO_00299 concentration in nail http://purl.obolibrary.org/obo/PBPKO_00297 biological matrix concentration A biological matrix concentration specifically representing the total concentration of compound in the nail compartment. http://purl.obolibrary.org/obo/PBPKO_00300 concentration in teeth http://purl.obolibrary.org/obo/PBPKO_00297 biological matrix concentration A biological matrix concentration specifically representing the total concentration of compound in the teeth compartment. http://purl.obolibrary.org/obo/PBPKO_00301 concentration in blood http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The total concentration of compound in the blood compartment. http://purl.obolibrary.org/obo/PBPKO_00302 concentration in urine http://purl.obolibrary.org/obo/PBPKO_00297 biological matrix concentration A biological matrix concentration specifically representing the total concentration of compound in the urine compartment. http://purl.obolibrary.org/obo/PBPKO_00303 permeability limited pbpk http://purl.obolibrary.org/obo/PBPKO_00003 physiologically based pharmacokinetic model A physiologically based pharmacokinetic model that considers the permeability across membranes as a limiting factor for compound distribution. http://purl.obolibrary.org/obo/PBPKO_00446 compartment http://purl.obolibrary.org/obo/OBI_0000658 data representational model A data representation model component representing a distinct physiological space (organ, tissue, fluid) where ADME processes occur. http://purl.obolibrary.org/obo/PBPKO_00316 population pbpk http://purl.obolibrary.org/obo/PBPKO_00003 physiologically based pharmacokinetic model A physiologically based pharmacokinetic model approach used to characterize interindividual variability within a population. http://purl.obolibrary.org/obo/PBPKO_00332 lifestage http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter A physiological parameter representing distinct phases of an individual's life (e.g., infant, adult, geriatric). http://purl.obolibrary.org/obo/PBPKO_00317 top-down pbpk http://purl.obolibrary.org/obo/PBPKO_00003 physiologically based pharmacokinetic model A physiologically based pharmacokinetic model approach primarily based on fitting observed clinical data, often empirical. http://purl.obolibrary.org/obo/PBPKO_00318 bottom-up pbpk http://purl.obolibrary.org/obo/PBPKO_00003 physiologically based pharmacokinetic model A physiologically based pharmacokinetic model approach built mechanistically using in vitro and physiological data. http://purl.obolibrary.org/obo/PBPKO_00319 one-compartment pbpk http://purl.obolibrary.org/obo/PBPKO_00003 physiologically based pharmacokinetic model A physiologically based pharmacokinetic model that treats the entire body as a single, kinetically homogenous unit (central compartment). http://purl.obolibrary.org/obo/PBPKO_00323 linear elimination http://purl.obolibrary.org/obo/PBPKO_00322 elimination An elimination process that follows first-order kinetics (rate proportional to concentration). http://purl.obolibrary.org/obo/PBPKO_00324 non-linear elimination http://purl.obolibrary.org/obo/PBPKO_00322 elimination An elimination process that does not follow first-order kinetics (e.g., saturable processes). http://purl.obolibrary.org/obo/PBPKO_00347 brain pbpk http://purl.obolibrary.org/obo/PBPKO_00003 physiologically based pharmacokinetic model A physiologically based pharmacokinetic model specifically built to predict compound concentrations in the brain. http://purl.obolibrary.org/obo/PBPKO_00351 blood brain barrier compartment http://purl.obolibrary.org/obo/PBPKO_00495 barrier compartment A barrier compartment representing the blood-brain barrier (BBB). http://purl.obolibrary.org/obo/PBPKO_00354 blood cerebrospinal fluid compartment http://purl.obolibrary.org/obo/PBPKO_00495 barrier compartment A barrier compartment representing the blood-cerebrospinal fluid barrier (BCSFB). http://purl.obolibrary.org/obo/PBPKO_00612 apparent permeability http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter representing the apparent permeability of a compound specifically between the compartments. http://purl.obolibrary.org/obo/PBPKO_00371 pregnant pbpk http://purl.obolibrary.org/obo/PBPKO_00003 physiologically based pharmacokinetic model A physiologically based pharmacokinetic model specifically built to predict compound concentrations during pregnancy. http://purl.obolibrary.org/obo/PBPKO_00395 kidney pbpk http://purl.obolibrary.org/obo/PBPKO_00003 physiologically based pharmacokinetic model A physiologically based pharmacokinetic model specifically built to predict compound concentrations within the kidney compartments. http://purl.obolibrary.org/obo/PBPKO_00396 Bowman's capsule compartment http://purl.obolibrary.org/obo/PBPKO_00557 kidney compartment A kidney compartment representing the Bowman's capsule. http://purl.obolibrary.org/obo/PBPKO_00397 filtrate compartment http://purl.obolibrary.org/obo/PBPKO_00557 kidney compartment A kidney compartment representing the filtrate within the nephron. http://purl.obolibrary.org/obo/PBPKO_00398 proximal tubule compartment http://purl.obolibrary.org/obo/PBPKO_00557 kidney compartment A kidney compartment representing the proximal tubule of the nephron. http://purl.obolibrary.org/obo/PBPKO_00399 loop of Henle compartment http://purl.obolibrary.org/obo/PBPKO_00557 kidney compartment A kidney compartment representing the loop of Henle within the nephron. http://purl.obolibrary.org/obo/PBPKO_00400 distal tubule compartment http://purl.obolibrary.org/obo/PBPKO_00557 kidney compartment A kidney compartment representing the distal tubule of the nephron. http://purl.obolibrary.org/obo/PBPKO_00401 collecting duct compartment http://purl.obolibrary.org/obo/PBPKO_00557 kidney compartment A kidney compartment representing the collecting duct system. http://purl.obolibrary.org/obo/PBPKO_00403 lung pbpk http://purl.obolibrary.org/obo/PBPKO_00003 physiologically based pharmacokinetic model A physiologically based pharmacokinetic model specifically built to predict compound concentrations within the lung compartments. http://purl.obolibrary.org/obo/PBPKO_00406 bronchiolar compartment http://purl.obolibrary.org/obo/PBPKO_00559 lung compartment A lung compartment representing the bronchioles. http://purl.obolibrary.org/obo/PBPKO_00407 alveolar compartment http://purl.obolibrary.org/obo/PBPKO_00559 lung compartment A lung compartment representing the alveoli. http://purl.obolibrary.org/obo/PBPKO_00408 gut pbpk http://purl.obolibrary.org/obo/PBPKO_00003 physiologically based pharmacokinetic model A physiologically based pharmacokinetic model specifically built to predict compound concentrations within the gut compartments. http://purl.obolibrary.org/obo/PBPKO_00435 lactational pbpk http://purl.obolibrary.org/obo/PBPKO_00003 physiologically based pharmacokinetic model A physiologically based pharmacokinetic model specifically built to predict compound concentrations during lactation, including transfer into milk. http://purl.obolibrary.org/obo/PBPKO_00438 concentration in milk http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The total concentration of compound in the milk compartment. http://purl.obolibrary.org/obo/PBPKO_00441 blood milk barrier compartment http://purl.obolibrary.org/obo/PBPKO_00495 barrier compartment A barrier compartment representing the physiological barrier separating blood and milk in lactating species. http://purl.obolibrary.org/obo/PBPKO_00448 alveolar air compartment http://purl.obolibrary.org/obo/PBPKO_00559 lung compartment A lung compartment specifically representing the air within the alveoli. http://purl.obolibrary.org/obo/PBPKO_00455 viable unexposed skin compartment http://purl.obolibrary.org/obo/PBPKO_00470 skin compartment A skin compartment representing the viable layers of skin not directly exposed to the applied compound. http://purl.obolibrary.org/obo/PBPKO_00456 viable exposed skin compartment http://purl.obolibrary.org/obo/PBPKO_00470 skin compartment A skin compartment representing the viable layers of skin directly exposed to the applied compound. http://purl.obolibrary.org/obo/PBPKO_00457 skin unexposed stratum corneum http://purl.obolibrary.org/obo/PBPKO_00493 stratum corneum compartment A stratum corneum compartment representing the portion not directly exposed to the applied compound. http://purl.obolibrary.org/obo/PBPKO_00493 stratum corneum compartment http://purl.obolibrary.org/obo/PBPKO_00470 skin compartment A skin compartment representing the stratum corneum layer. http://purl.obolibrary.org/obo/PBPKO_00458 skin exposed stratum corneum compartment http://purl.obolibrary.org/obo/PBPKO_00493 stratum corneum compartment A stratum corneum compartment representing the portion directly exposed to the applied compound. http://purl.obolibrary.org/obo/PBPKO_00461 anal canal compartment http://purl.obolibrary.org/obo/PBPKO_00474 large intestine compartment A large intestine compartment representing the anal canal. http://purl.obolibrary.org/obo/PBPKO_00474 large intestine compartment http://purl.obolibrary.org/obo/PBPKO_00553 digestive system compartment A digestive system compartment representing the large intestine. http://purl.obolibrary.org/obo/PBPKO_00462 appendix compartment http://purl.obolibrary.org/obo/PBPKO_00474 large intestine compartment A large intestine compartment representing the appendix. http://purl.obolibrary.org/obo/PBPKO_00463 ascending colon compartment http://purl.obolibrary.org/obo/PBPKO_00474 large intestine compartment A large intestine compartment representing the ascending colon. http://purl.obolibrary.org/obo/PBPKO_00467 cecum compartment http://purl.obolibrary.org/obo/PBPKO_00474 large intestine compartment A large intestine compartment representing the cecum. http://purl.obolibrary.org/obo/PBPKO_00468 descending colon compartment http://purl.obolibrary.org/obo/PBPKO_00474 large intestine compartment A large intestine compartment representing the descending colon. http://purl.obolibrary.org/obo/PBPKO_00469 dermis compartment http://purl.obolibrary.org/obo/PBPKO_00470 skin compartment A skin compartment representing the dermis layer. http://purl.obolibrary.org/obo/PBPKO_00471 duodenum compartment http://purl.obolibrary.org/obo/PBPKO_00472 small intestine compartment A small intestine compartment representing the duodenum. http://purl.obolibrary.org/obo/PBPKO_00472 small intestine compartment http://purl.obolibrary.org/obo/PBPKO_00553 digestive system compartment A digestive system compartment representing the small intestine. http://purl.obolibrary.org/obo/PBPKO_00475 epidermis compartment http://purl.obolibrary.org/obo/PBPKO_00470 skin compartment A skin compartment representing the epidermis layer. http://purl.obolibrary.org/obo/PBPKO_00476 gall bladder compartment http://purl.obolibrary.org/obo/PBPKO_00553 digestive system compartment A digestive system compartment representing the gall bladder. http://purl.obolibrary.org/obo/PBPKO_00477 gut compartment http://purl.obolibrary.org/obo/PBPKO_00553 digestive system compartment A digestive system compartment representing the gut (general term, often synonymous with intestine or GI tract). http://purl.obolibrary.org/obo/PBPKO_00478 gut lumen compartment http://purl.obolibrary.org/obo/PBPKO_00553 digestive system compartment A digestive system compartment representing the lumen (opening) within the gut. http://purl.obolibrary.org/obo/PBPKO_00481 ileum compartment http://purl.obolibrary.org/obo/PBPKO_00472 small intestine compartment A small intestine compartment representing the ileum. http://purl.obolibrary.org/obo/PBPKO_00482 jejunum compartment http://purl.obolibrary.org/obo/PBPKO_00472 small intestine compartment A small intestine compartment representing the jejunum. http://purl.obolibrary.org/obo/PBPKO_00487 placental barrier compartment http://purl.obolibrary.org/obo/PBPKO_00495 barrier compartment A barrier compartment representing the placental barrier separating maternal and fetal circulation. http://purl.obolibrary.org/obo/PBPKO_00489 rectum compartment http://purl.obolibrary.org/obo/PBPKO_00474 large intestine compartment A large intestine compartment representing the rectum. http://purl.obolibrary.org/obo/PBPKO_00491 sigmoid colon compartment http://purl.obolibrary.org/obo/PBPKO_00474 large intestine compartment A large intestine compartment representing the sigmoid colon. http://purl.obolibrary.org/obo/PBPKO_00494 transverse colon compartment http://purl.obolibrary.org/obo/PBPKO_00474 large intestine compartment A large intestine compartment representing the transverse colon. http://purl.obolibrary.org/obo/PBPKO_00496 amount in gut http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the gut compartment. http://purl.obolibrary.org/obo/PBPKO_00497 amount in liver http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the liver compartment. http://purl.obolibrary.org/obo/PBPKO_00498 amount in kidney http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the kidney compartment. http://purl.obolibrary.org/obo/PBPKO_00499 amount in filtrate http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the filtrate compartment. http://purl.obolibrary.org/obo/PBPKO_00500 amount in delay http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the hypothetical delay compartment. http://purl.obolibrary.org/obo/PBPKO_00501 amount in restbody http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the rest of the body compartment. http://purl.obolibrary.org/obo/PBPKO_00502 amount in plasma http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the plasma compartment. http://purl.obolibrary.org/obo/PBPKO_00503 amount in brain http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the brain compartment. http://purl.obolibrary.org/obo/PBPKO_00504 amount in lung http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the lung compartment. http://purl.obolibrary.org/obo/PBPKO_00505 amount in bone marrow http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the bone marrow compartment. http://purl.obolibrary.org/obo/PBPKO_00506 amount in skin http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the skin compartment. http://purl.obolibrary.org/obo/PBPKO_00507 amount in mammary gland http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the mammary gland compartment. http://purl.obolibrary.org/obo/PBPKO_00538 concentration in gut http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The total concentration of compound in the gut compartment. http://purl.obolibrary.org/obo/PBPKO_00539 concentration in liver http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The total concentration of compound in the liver compartment. http://purl.obolibrary.org/obo/PBPKO_00540 concentration in brain http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The total concentration of compound in the brain compartment. http://purl.obolibrary.org/obo/PBPKO_00541 concentration in kidney http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The total concentration of compound in the kidney compartment. http://purl.obolibrary.org/obo/PBPKO_00542 concentration in filtrate http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The total concentration of compound in the filtrate compartment. http://purl.obolibrary.org/obo/PBPKO_00543 concentration in lung http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The total concentration of compound in the lung compartment. http://purl.obolibrary.org/obo/PBPKO_00544 concentration in fat http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The total concentration of compound in the fat compartment. http://purl.obolibrary.org/obo/PBPKO_00545 concentration in bone marrow http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The total concentration of compound in the bone marrow compartment. http://purl.obolibrary.org/obo/PBPKO_00546 concentration in skin http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The total concentration of compound in the skin compartment. http://purl.obolibrary.org/obo/PBPKO_00547 concentration in mammary gland http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The total concentration of compound in the mammary gland compartment. http://purl.obolibrary.org/obo/PBPKO_00548 concentration in restbody http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The total concentration of compound in the rest of body compartment. http://purl.obolibrary.org/obo/PBPKO_00550 amount in fat http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the fat compartment. http://purl.obolibrary.org/obo/PBPKO_00551 PBPK model simulation time http://purl.obolibrary.org/obo/PBPKO_00002 parameter A parameter representing the time duration over which the model simulation runs. http://purl.obolibrary.org/obo/PBPKO_00562 blood flow rate to unexposed skin http://purl.obolibrary.org/obo/PBPKO_00036 blood flow rate to skin A blood flow rate to skin parameter specifically describing the rate to the unexposed portion of the skin compartment. http://purl.obolibrary.org/obo/PBPKO_00563 blood flow rate to exposed skin http://purl.obolibrary.org/obo/PBPKO_00036 blood flow rate to skin A blood flow rate to skin parameter specifically describing the rate to the exposed portion of the skin compartment. http://purl.obolibrary.org/obo/PBPKO_00564 blood flow rate to skin stratum corneum unexposed http://purl.obolibrary.org/obo/PBPKO_00036 blood flow rate to skin A blood flow rate to skin parameter specifically describing the rate to the unexposed stratum corneum compartment. http://purl.obolibrary.org/obo/PBPKO_00565 blood flow rate to skin stratum corneum exposed http://purl.obolibrary.org/obo/PBPKO_00036 blood flow rate to skin A blood flow rate to skin parameter specifically describing the rate to the exposed stratum corneum compartment. http://purl.obolibrary.org/obo/PBPKO_00566 stomach compartment http://purl.obolibrary.org/obo/PBPKO_00553 digestive system compartment A digestive system compartment representing the stomach. http://purl.obolibrary.org/obo/PBPKO_00567 bone blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in bone to blood. http://purl.obolibrary.org/obo/PBPKO_00568 air blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in air to blood. http://purl.obolibrary.org/obo/PBPKO_00569 brain blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in brain to blood. http://purl.obolibrary.org/obo/PBPKO_00570 brainfetus blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the fetal brain to blood. http://purl.obolibrary.org/obo/PBPKO_00571 gonad blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in gonads to blood. http://purl.obolibrary.org/obo/PBPKO_00572 gut blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the gut to blood. http://purl.obolibrary.org/obo/PBPKO_00573 heart blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the heart to blood. http://purl.obolibrary.org/obo/PBPKO_00574 intestine blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the intestine to blood. http://purl.obolibrary.org/obo/PBPKO_00575 kidney blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the kidney to blood. http://purl.obolibrary.org/obo/PBPKO_00576 kidneyfetus blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the fetal kidney to blood. http://purl.obolibrary.org/obo/PBPKO_00577 liver blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the liver to blood. http://purl.obolibrary.org/obo/PBPKO_00578 liverfetus blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the fetal liver to blood. http://purl.obolibrary.org/obo/PBPKO_00579 lung blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the lung to blood. http://purl.obolibrary.org/obo/PBPKO_00580 mammary gland blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the mammary gland to blood. http://purl.obolibrary.org/obo/PBPKO_00581 milk blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in milk to blood. http://purl.obolibrary.org/obo/PBPKO_00582 muscle blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in muscle to blood. http://purl.obolibrary.org/obo/PBPKO_00583 pancreas blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the pancreas to blood. http://purl.obolibrary.org/obo/PBPKO_00584 poor perfused blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the poorly perfused compartment to blood. http://purl.obolibrary.org/obo/PBPKO_00585 restbody blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the rest of body compartment to blood. http://purl.obolibrary.org/obo/PBPKO_00586 restbodyfetus blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the fetal rest of body compartment to blood. http://purl.obolibrary.org/obo/PBPKO_00587 rich perfused blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the richly perfused compartment to blood. http://purl.obolibrary.org/obo/PBPKO_00588 skin blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the skin to blood. http://purl.obolibrary.org/obo/PBPKO_00589 spleen blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the spleen to blood. http://purl.obolibrary.org/obo/PBPKO_00590 stomach blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in the stomach to blood. http://purl.obolibrary.org/obo/PBPKO_00591 fraction unbound plasma http://purl.obolibrary.org/obo/PBPKO_00149 unbound fraction An unbound fraction parameter specifically for plasma. http://purl.obolibrary.org/obo/PBPKO_00592 maximum rate of apical transporter http://purl.obolibrary.org/obo/PBPKO_00613 maximum rate A maximum rate (Vmax) of an enzyme catalysed reaction for a compound across the apical membrane of an organ when the enzyme is saturated with substrate. http://purl.obolibrary.org/obo/PBPKO_00593 maximum rate of basolateral transporter http://purl.obolibrary.org/obo/PBPKO_00613 maximum rate Maximum rate (Vmax) of transport via a basolateral transporter. http://purl.obolibrary.org/obo/PBPKO_00617 hippocampus compartment http://purl.obolibrary.org/obo/PBPKO_00466 brain compartment A part of brain compartment representing the hippocampus region of the brain http://purl.obolibrary.org/obo/PBPKO_00618 cerebrum compartment http://purl.obolibrary.org/obo/PBPKO_00466 brain compartment A part of brain compartment representing the cerebrum region of the brain http://purl.obolibrary.org/obo/PBPKO_00619 cerebellum compartment http://purl.obolibrary.org/obo/PBPKO_00466 brain compartment A part of brain compartment representing the cerebellum region of the brain http://purl.obolibrary.org/obo/PBPKO_00620 frontal cortex compartment http://purl.obolibrary.org/obo/PBPKO_00466 brain compartment A part of brain compartment representing the frontal cortex region of the brain http://purl.obolibrary.org/obo/PBPKO_00621 cerebrospinal fluid compartment http://purl.obolibrary.org/obo/PBPKO_00466 brain compartment A part of brain compartment representing the cerebrospinal fluid region of the brain http://purl.obolibrary.org/obo/PBPKO_00622 fraction unbound blood http://purl.obolibrary.org/obo/PBPKO_00149 unbound fraction An unbound fraction parameter specifically for the blood compartment. http://purl.obolibrary.org/obo/PBPKO_00623 amount in blood http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the blood compartment. http://purl.obolibrary.org/obo/PBPKO_00624 fraction unbound restbody http://purl.obolibrary.org/obo/PBPKO_00149 unbound fraction An unbound fraction parameter specifically for the rest of the body compartment. http://purl.obolibrary.org/obo/PBPKO_00625 exposed skin compartment http://purl.obolibrary.org/obo/PBPKO_00470 skin compartment A skin compartment representing the exposed part of the skin to the chemical via dermal contact. http://purl.obolibrary.org/obo/PBPKO_00626 unexposed skin compartment http://purl.obolibrary.org/obo/PBPKO_00470 skin compartment A skin compartment representing the unexposed part of the skin to the chemical such as regions covered by clothing or occluded areas like the inner arms. http://purl.obolibrary.org/obo/PBPKO_00627 fraction of arterial plasma volume http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the arterial plasma volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00628 fraction of venous plasma volume http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the venous plasma volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_00629 amount in richly perfused tissue http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the richly perfused tissue compartment. http://purl.obolibrary.org/obo/PBPKO_00630 amount in poorly perfused tissue http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the poorly perfused tissue compartment. http://purl.obolibrary.org/obo/PBPKO_00631 amount in arterial blood http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the arterial blood compartment. http://purl.obolibrary.org/obo/PBPKO_00632 amount in venous blood http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the venous blood compartment. http://purl.obolibrary.org/obo/PBPKO_00633 amount in alveolar air http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the alveolar air compartment. http://purl.obolibrary.org/obo/PBPKO_00634 red blood cell compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the red blood cells of the body. http://purl.obolibrary.org/obo/PBPKO_00635 skin thickness http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter A physiological parameter representing the thickness of the skin compartment http://purl.obolibrary.org/obo/PBPKO_00637 amount in viable epidermis of unexposed skin http://purl.obolibrary.org/obo/PBPKO_00506 amount in skin The amount of chemical in viable epidermis of unexposed skin http://purl.obolibrary.org/obo/PBPKO_00638 amount in viable epidermis of exposed skin http://purl.obolibrary.org/obo/PBPKO_00506 amount in skin The amount of chemical in viable epidermis of exposed skin http://purl.obolibrary.org/obo/PBPKO_00639 amount in skin stratum corneum of unexposed skin http://purl.obolibrary.org/obo/PBPKO_00506 amount in skin The amount of chemical in skin stratum corneum of unexposed skin http://purl.obolibrary.org/obo/PBPKO_00640 amount in skin stratum corneum of exposed skin http://purl.obolibrary.org/obo/PBPKO_00506 amount in skin The amount of chemical in skin stratum corneum of exposed skin http://purl.obolibrary.org/obo/PBPKO_00641 dermal absorption rate unexposed skin http://purl.obolibrary.org/obo/PBPKO_03075 absorption rate constant An absorption rate constant parameter representing dermal absorption rate flux through unexposed skin http://purl.obolibrary.org/obo/PBPKO_00642 dermal absorption rate exposed skin http://purl.obolibrary.org/obo/PBPKO_03075 absorption rate constant An absorption rate constant parameter representing dermal absorption rate flux through exposed skin http://purl.obolibrary.org/obo/PBPKO_00643 thickness stratum corneum http://purl.obolibrary.org/obo/PBPKO_00635 skin thickness A skin thickness parameter representing the thickness of stratum corneum. http://purl.obolibrary.org/obo/PBPKO_00644 thickness viable epidermis http://purl.obolibrary.org/obo/PBPKO_00635 skin thickness A skin thickness parameter representing the thickness of viable epidermis. http://purl.obolibrary.org/obo/PBPKO_00645 fat blood partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient A partition coefficient representing the ratio of compound concentration in fat to blood. http://purl.obolibrary.org/obo/PBPKO_00646 diffusion rate http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter representing the diffusion rate of the chemical http://purl.obolibrary.org/obo/PBPKO_00647 diffusion rate skin http://purl.obolibrary.org/obo/PBPKO_00646 diffusion rate A diffusion rate parameter representing diffusion rate of the chemical across the skin http://purl.obolibrary.org/obo/PBPKO_00648 diffusion rate stratum corneum viable epidermis http://purl.obolibrary.org/obo/PBPKO_00647 diffusion rate skin A diffusion rate skin parameter representing diffusion rate from stratum corneum to viable epidermis http://purl.obolibrary.org/obo/PBPKO_00649 miscellaneous parameter http://purl.obolibrary.org/obo/PBPKO_00002 parameter A parameter being used in the model but does not belong to specific parameter subclass http://purl.obolibrary.org/obo/PBPKO_00650 Michaelis http://purl.obolibrary.org/obo/PBPKO_00649 miscellaneous parameter A flag indicating for Michaelis-Menten or linear metabolism equation being used in the model http://purl.obolibrary.org/obo/PBPKO_00651 fraction of arterial blood volume http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the arterial blood volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_06004 amount in stomach http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of chemical in stomach compartment. http://purl.obolibrary.org/obo/PBPKO_06005 amount in small intestine http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of chemical in small intestine compartment http://purl.obolibrary.org/obo/PBPKO_06009 amount in lumen http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of chemical in lumen of the intestine. http://purl.obolibrary.org/obo/PBPKO_06047 concentration in lumen http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The concentration of chemical in lumen of intestine. http://purl.obolibrary.org/obo/PBPKO_03001 intrinsic gastric emptying rate http://purl.obolibrary.org/obo/PBPKO_03075 absorption rate constant The absorption rate constant parameter representing the intrinsic rate of the chemical release from stomach to lumen or the jejunum segment http://purl.obolibrary.org/obo/OBI_0002205 histologic grade according to AJCC 7th edition http://purl.obolibrary.org/obo/OBI_0001930 categorical value specification A categorical value specification that is a histologic grade assigned to a tumor slide specimen according to the American Joint Committee on Cancer (AJCC) 7th Edition grading system. http://purl.obolibrary.org/obo/OBI_0002210 histologic grade according to the Fuhrman Nuclear Grading System http://purl.obolibrary.org/obo/OBI_0001930 categorical value specification A categorical value specification that is a histologic grade assigned to a tumor slide specimen according to the Fuhrman Nuclear Grading System. http://purl.obolibrary.org/obo/OBI_0002215 histologic grade for ovarian tumor http://purl.obolibrary.org/obo/OBI_0001930 categorical value specification A categorical value specification that is a histologic grade assigned to a ovarian tumor. http://purl.obolibrary.org/obo/OBI_0002216 histologic grade for ovarian tumor according to a two-tier grading system http://purl.obolibrary.org/obo/OBI_0002215 histologic grade for ovarian tumor A histologic grade for ovarian tumor that is from a two-tier histological classification of tumors. http://purl.obolibrary.org/obo/OBI_0002219 histologic grade for ovarian tumor according to the World Health Organization http://purl.obolibrary.org/obo/OBI_0002215 histologic grade for ovarian tumor A histologic grade for ovarian tumor that is from a histological classification by the World Health Organization (WHO). http://purl.obolibrary.org/obo/OBI_0002224 pathologic primary tumor stage for colon and rectum according to AJCC 7th edition http://purl.obolibrary.org/obo/OBI_0001930 categorical value specification A categorical value specification that is a pathologic finding about one or more characteristics of colorectal cancer following the rules of the TNM American Joint Committee on Cancer (AJCC) version 7 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery. http://purl.obolibrary.org/obo/OBI_0002232 pathologic primary tumor stage for lung according to AJCC 7th edition http://purl.obolibrary.org/obo/OBI_0001930 categorical value specification A categorical value specification that is a pathologic finding about one or more characteristics of lung cancer following the rules of the TNM American Joint Committee on Cancer (AJCC) version 7 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery. http://purl.obolibrary.org/obo/OBI_0002243 pathologic primary tumor stage for kidney according to AJCC 7th edition http://purl.obolibrary.org/obo/OBI_0001930 categorical value specification A categorical value specification that is a pathologic finding about one or more characteristics of renal cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery. http://purl.obolibrary.org/obo/OBI_0002256 pathologic primary tumor stage for ovary according to AJCC 7th edition http://purl.obolibrary.org/obo/OBI_0001930 categorical value specification A categorical value specification that is a pathologic finding about one or more characteristics of ovarian cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of the primary tumor. TNM pathologic primary tumor findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery. http://purl.obolibrary.org/obo/OBI_0002270 pathologic lymph node stage for colon and rectum according to AJCC 7th edition http://purl.obolibrary.org/obo/OBI_0001930 categorical value specification A categorical value specification that is a pathologic finding about one or more characteristics of colorectal cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes. http://purl.obolibrary.org/obo/OBI_0002279 pathologic lymph node stage for lung according to AJCC 7th edition http://purl.obolibrary.org/obo/OBI_0001930 categorical value specification A categorical value specification that is a pathologic finding about one or more characteristics of lung cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes. http://purl.obolibrary.org/obo/OBI_0002284 pathologic lymph node stage for kidney according to AJCC 7th edition http://purl.obolibrary.org/obo/OBI_0001930 categorical value specification A categorical value specification that is a pathologic finding about one or more characteristics of renal cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes. http://purl.obolibrary.org/obo/OBI_0002287 pathologic lymph node stage for ovary according to AJCC 7th edition http://purl.obolibrary.org/obo/OBI_0001930 categorical value specification A categorical value specification that is a pathologic finding about one or more characteristics of ovarian cancer following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes. http://purl.obolibrary.org/obo/OBI_0002290 pathologic distant metastases stage for colon according to AJCC 7th edition http://purl.obolibrary.org/obo/OBI_0001930 categorical value specification A categorical value specification that is a pathologic finding about one or more characteristics of colon cancer following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery. http://purl.obolibrary.org/obo/OBI_0002298 pathologic distant metastases stage for lung according to AJCC 7th edition http://purl.obolibrary.org/obo/OBI_0001930 categorical value specification A categorical value specification that is a pathologic finding about one or more characteristics of lung cancer following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery. http://purl.obolibrary.org/obo/OBI_0002306 pathologic distant metastases stage for kidney according to AJCC 7th edition http://purl.obolibrary.org/obo/OBI_0001930 categorical value specification A categorical value specification that is a pathologic finding about one or more characteristics of renal cancer following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery. http://purl.obolibrary.org/obo/OBI_0002310 pathologic distant metastases stage for ovary according to AJCC 7th edition http://purl.obolibrary.org/obo/OBI_0001930 categorical value specification A categorical value specification that is a pathologic finding about one or more characteristics of ovarian cancer following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. TNM pathologic distant metastasis findings are based on clinical findings supplemented by histopathologic examination of one or more tissue specimens acquired during surgery. http://purl.obolibrary.org/obo/OBI_0002314 clinical tumor stage group according to AJCC 7th edition http://purl.obolibrary.org/obo/OBI_0001930 categorical value specification A categorical value specification that is an assessment of the stage of a cancer according to the American Joint Committee on Cancer (AJCC) v7 staging systems. http://purl.obolibrary.org/obo/OBI_0002326 International Federation of Gynecology and Obstetrics cervical cancer stage value specification http://purl.obolibrary.org/obo/OBI_0001930 categorical value specification A categorical value specification that is an assessment of the stage of a gynecologic cancer according to the International Federation of Gynecology and Obstetrics (FIGO) staging systems. http://purl.obolibrary.org/obo/OBI_0002341 International Federation of Gynecology and Obstetrics ovarian cancer stage value specification http://purl.obolibrary.org/obo/OBI_0001930 categorical value specification A categorical value specification that is a pathologic finding about one or more characteristics of ovarian cancer following the rules of the FIGO classification system. http://purl.obolibrary.org/obo/OBI_0002356 performance status value specification http://purl.obolibrary.org/obo/OBI_0001930 categorical value specification A categorical value specification that is an assessment of a participant's performance status (general well-being and activities of daily life). http://purl.obolibrary.org/obo/OBI_0002357 Eastern Cooperative Oncology Group score value specification http://purl.obolibrary.org/obo/OBI_0002356 performance status value specification A performance status value specification designed by the Eastern Cooperative Oncology Group to assess disease progression and its affect on the daily living abilities of the patient. http://purl.obolibrary.org/obo/OBI_0002363 Karnofsky score vaue specification http://purl.obolibrary.org/obo/OBI_0002356 performance status value specification A performance status value specification designed for classifying patients 16 years of age or older by their functional impairment. http://purl.obolibrary.org/obo/OBI_0002989 material supplier http://purl.obolibrary.org/obo/BFO_0000040 material entity A person or organization that provides material supplies to other people or organizations. http://purl.obolibrary.org/obo/PBPKO_03075 absorption rate constant http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter A biochemical parameter representing the rate constant at which a compound is absorbed into systemic circulation or a target compartment from the site of administration http://purl.obolibrary.org/obo/PBPKO_02001 bile compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the bile storage http://purl.obolibrary.org/obo/PBPKO_02002 colon compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the colon http://purl.obolibrary.org/obo/PBPKO_02003 small intestine tissue compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the small intestinal tissue http://purl.obolibrary.org/obo/PBPKO_02004 intestinal tissue compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing the whole intestinal tissue http://purl.obolibrary.org/obo/PBPKO_02005 portal vein perfused tissue comparment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment with grouped organs that are exclusively perfused via the portal vein (i.e.: Stomach, small and large intestine, spleen) http://purl.obolibrary.org/obo/PBPKO_02006 glomerulus compartment http://purl.obolibrary.org/obo/PBPKO_00557 kidney compartment A part of kidney compartment in the model representing glomerulus in the body http://purl.obolibrary.org/obo/PBPKO_02007 menstrual plasma compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing menstrual plasma http://purl.obolibrary.org/obo/PBPKO_02008 kidney rest lumen compartment http://purl.obolibrary.org/obo/PBPKO_00557 kidney compartment A compartment representing rest of the lumen of kidney. http://purl.obolibrary.org/obo/PBPKO_02009 kidney proximal tubule tissue compartment http://purl.obolibrary.org/obo/PBPKO_00557 kidney compartment A compartment representing rest of the tissue of kidney. http://purl.obolibrary.org/obo/PBPKO_02010 liver extracellular compartment http://purl.obolibrary.org/obo/PBPKO_00558 liver compartment A compartment representing vascular and interstitial space of the liver. http://purl.obolibrary.org/obo/PBPKO_02011 liver intracellular space compartment http://purl.obolibrary.org/obo/PBPKO_00558 liver compartment A compartment representing intracellular space of the liver. http://purl.obolibrary.org/obo/PBPKO_02012 gastro intestinal tract compartment http://purl.obolibrary.org/obo/PBPKO_00553 digestive system compartment A digestive system compartment representing the gastro-intestinal tract http://purl.obolibrary.org/obo/PBPKO_02013 gonad compartment http://purl.obolibrary.org/obo/PBPKO_00446 compartment A compartment representing gonads. http://purl.obolibrary.org/obo/PBPKO_03002 intrinsic absorption rate http://purl.obolibrary.org/obo/PBPKO_03075 absorption rate constant The absorption rate constant parameter representing the intrinsic absorption rate from the gut or any intestinal segment to the liver or the portal vein http://purl.obolibrary.org/obo/PBPKO_03003 intrinsic stomach uptake rate http://purl.obolibrary.org/obo/PBPKO_03075 absorption rate constant The absorption rate constant parameter representing the intrinsic absorption rate of a chemical from the stomach to the gut tissue or any intestinal segment http://purl.obolibrary.org/obo/PBPKO_03004 stomach uptake rate http://purl.obolibrary.org/obo/PBPKO_03075 absorption rate constant The absorption rate constant parameter representing the absorption rate from stomach to gut tissue or any intestine segment http://purl.obolibrary.org/obo/PBPKO_03076 fraction unbound kidney proximal tubule http://purl.obolibrary.org/obo/PBPKO_00149 unbound fraction An unbound fraction parameter specifically for the kidney proximal tubule. http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate http://purl.obolibrary.org/obo/PBPKO_00636 bodily fluid flow rate parameter A bodily fluid flow rate parameter specifically describing the flow of plasma to a compartment. http://purl.obolibrary.org/obo/PBPKO_04002 plasma flow rate to stomach http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the stomach compartment. http://purl.obolibrary.org/obo/PBPKO_04003 plasma flow rate to intestine http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the intestine compartment. http://purl.obolibrary.org/obo/PBPKO_04004 plasma flow rate to small intestine http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the small intestine compartment. http://purl.obolibrary.org/obo/PBPKO_04005 plasma flow rate to large intestine http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the large intestine compartment. http://purl.obolibrary.org/obo/PBPKO_04006 plasma flow rate to pancreas http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the pancreas compartment. http://purl.obolibrary.org/obo/PBPKO_04007 plasma flow rate to liver http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the liver compartment. http://purl.obolibrary.org/obo/PBPKO_04008 plasma flow rate to kidney http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the kidney compartment. http://purl.obolibrary.org/obo/PBPKO_04009 plasma flow rate to muscle http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the muscle compartment. http://purl.obolibrary.org/obo/PBPKO_04010 plasma flow rate to heart http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the heart compartment. http://purl.obolibrary.org/obo/PBPKO_04011 plasma flow rate to fat http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the fat compartment. http://purl.obolibrary.org/obo/PBPKO_04012 plasma flow rate to gonad http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the gonad compartment. http://purl.obolibrary.org/obo/PBPKO_04013 plasma flow rate to skin http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the skin compartment. http://purl.obolibrary.org/obo/PBPKO_04014 plasma flow rate to bone http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the bone compartment. http://purl.obolibrary.org/obo/PBPKO_04015 plasma flow rate to brain http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the brain compartment. http://purl.obolibrary.org/obo/PBPKO_04016 plasma flow rate to spleen http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the spleen compartment. http://purl.obolibrary.org/obo/PBPKO_04017 plasma flow rate to lung http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the lung compartment. http://purl.obolibrary.org/obo/PBPKO_04018 plasma flow rate to poorly perfused http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the poorly perfused compartment. http://purl.obolibrary.org/obo/PBPKO_04019 plasma flow rate to richly perfused http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the richly perfused compartment. http://purl.obolibrary.org/obo/PBPKO_04020 plasma flow rate to restbody http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the rest of the body compartment. http://purl.obolibrary.org/obo/PBPKO_04021 plasma flow rate to gall bladder http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the gall bladder compartment. http://purl.obolibrary.org/obo/PBPKO_04022 plasma flow rate to portal vein http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the portal vein compartment. http://purl.obolibrary.org/obo/PBPKO_04023 plasma flow rate to lymph http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the lymph compartment. http://purl.obolibrary.org/obo/PBPKO_04024 plasma flow rate to duodenum http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the duodenum compartment. http://purl.obolibrary.org/obo/PBPKO_04025 plasma flow rate to jejunum http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the jejunum compartment. http://purl.obolibrary.org/obo/PBPKO_04026 plasma flow rate to ileum http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the ileum compartment. http://purl.obolibrary.org/obo/PBPKO_04027 plasma flow rate to colon http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the colon compartment. http://purl.obolibrary.org/obo/PBPKO_04028 plasma flow rate to cecum http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the cecum compartment. http://purl.obolibrary.org/obo/PBPKO_04029 plasma flow rate to filtrate http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the filtrate compartment. http://purl.obolibrary.org/obo/PBPKO_04030 plasma flow rate to bone marrow http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow parameter specifically describing the rate to the bone marrow compartment. http://purl.obolibrary.org/obo/PBPKO_04031 plasma flow rate to gut http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the gut compartment. http://purl.obolibrary.org/obo/PBPKO_04032 plasma flow rate to mammary gland http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the mammary gland compartment. http://purl.obolibrary.org/obo/PBPKO_04033 plasma flow rate for mass balance http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter representing the check for total plasma flow mass balance of all the compartments (sum of organ flows should equal cardiac output). http://purl.obolibrary.org/obo/PBPKO_04034 plasma flow rate to unexposed skin http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the unexposed skin compartment. http://purl.obolibrary.org/obo/PBPKO_04035 plasma flow rate to exposed skin http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the exposed skin compartment. http://purl.obolibrary.org/obo/PBPKO_04036 plasma flow rate to skin stratum corneum unexposed http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the unexposed stratum corneum compartment. http://purl.obolibrary.org/obo/PBPKO_04037 plasma flow rate to skin stratum corneum exposed http://purl.obolibrary.org/obo/PBPKO_04001 plasma flow rate A plasma flow rate parameter specifically describing the rate to the exposed stratum corneum compartment. http://purl.obolibrary.org/obo/PBPKO_04100 fraction of blood http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the blood volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_04101 fraction of bone marrow http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the bone marrow volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_04102 fraction of bone non perfused http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the bone non perfuse volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_04104 fraction of intestinal tissue http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment A dimensionless fraction of volume defined as the intestinal tissue volume divided per unit of total body weight. http://purl.obolibrary.org/obo/PBPKO_04105 volume of kidney rest tissue http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the kidney rest tissue compartment. http://purl.obolibrary.org/obo/PBPKO_04106 volume of kidney rest lumen http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the kidney rest lumen compartment. http://purl.obolibrary.org/obo/PBPKO_04107 volume of kidney proximal tubule lumen http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the lumen of kidney proximal tubule compartment. http://purl.obolibrary.org/obo/PBPKO_04108 volume of kidney proximal tubule tissue http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the tissue of kidney proximal tubule compartment. http://purl.obolibrary.org/obo/PBPKO_04109 volume of liver extracellular http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the vascular and interstitial spaces of liver compartment. http://purl.obolibrary.org/obo/PBPKO_04111 volume of intestine tissue http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment A volume parameter representing the total volume of the tissue of intestine compartment. http://purl.obolibrary.org/obo/PBPKO_05001 molar volume http://purl.obolibrary.org/obo/PBPKO_00126 physicochemical parameter A physicochemical parameter representing the volume of one mole of a molecule. http://purl.obolibrary.org/obo/PBPKO_05002 Henry's law constant http://purl.obolibrary.org/obo/PBPKO_00126 physicochemical parameter A physicochemical parameter describing the volatily of a compound http://purl.obolibrary.org/obo/PBPKO_05003 vapor pressure http://purl.obolibrary.org/obo/PBPKO_00126 physicochemical parameter A physicochemical parameter describing the vapor pressure of the compound http://purl.obolibrary.org/obo/PBPKO_06006 amount in jejunum http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of chemical in jejunum compartment. http://purl.obolibrary.org/obo/PBPKO_06007 amount in ileum http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of chemical in ileum compartment. http://purl.obolibrary.org/obo/PBPKO_06008 amount in large intestine http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of chemical in large intestine compartment. http://purl.obolibrary.org/obo/PBPKO_06010 amount in small intestine segment http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of chemical in segment of small intestine. http://purl.obolibrary.org/obo/PBPKO_06011 amount in colon http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of chemical in colon compartment. http://purl.obolibrary.org/obo/PBPKO_06012 amount in bile http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of chemical in bile. http://purl.obolibrary.org/obo/PBPKO_06013 amount in spleen http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of chemical in spleen compartment http://purl.obolibrary.org/obo/PBPKO_06014 amount in duodenum http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of chemical in duodenum compartment. http://purl.obolibrary.org/obo/PBPKO_06015 amount in intestinal tissue http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of chemical in intestinal tissue http://purl.obolibrary.org/obo/PBPKO_06016 amount in portal vein http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of chemical in portal vein. http://purl.obolibrary.org/obo/PBPKO_06017 unbound concentration in plasma http://purl.obolibrary.org/obo/PBPKO_06003 unbound concentration of compund in compartment The unbound concentration of compound in the plasma compartment. http://purl.obolibrary.org/obo/PBPKO_06018 unbound venous liver concentration http://purl.obolibrary.org/obo/PBPKO_06002 unbound venous concentration of compound in compartment The unbound venous concentration of compound in the liver compartment. http://purl.obolibrary.org/obo/PBPKO_06019 unbound venous gut concentration http://purl.obolibrary.org/obo/PBPKO_06002 unbound venous concentration of compound in compartment The unbound venous concentration of compound in the gut compartment. http://purl.obolibrary.org/obo/PBPKO_06020 unbound venous brain concentration http://purl.obolibrary.org/obo/PBPKO_06002 unbound venous concentration of compound in compartment The unbound venous concentration of compound in the brain compartment. http://purl.obolibrary.org/obo/PBPKO_06021 unbound venous kidney concentration http://purl.obolibrary.org/obo/PBPKO_06002 unbound venous concentration of compound in compartment The unbound venous concentration of compound in the kidney compartment. http://purl.obolibrary.org/obo/PBPKO_06022 unbound venous filtrate concentration http://purl.obolibrary.org/obo/PBPKO_06002 unbound venous concentration of compound in compartment The unbound venous concentration of compound in the filtrate compartment. http://purl.obolibrary.org/obo/PBPKO_06023 unbound venous lung concentration http://purl.obolibrary.org/obo/PBPKO_06002 unbound venous concentration of compound in compartment The unbound venous concentration of compound in the lung compartment. http://purl.obolibrary.org/obo/PBPKO_06024 unbound venous fat concentration http://purl.obolibrary.org/obo/PBPKO_06002 unbound venous concentration of compound in compartment The unbound venous concentration of compound in the fat compartment. http://purl.obolibrary.org/obo/PBPKO_06025 unbound venous bone marrow concentration http://purl.obolibrary.org/obo/PBPKO_06002 unbound venous concentration of compound in compartment The unbound venous concentration of compound in the bone marrow compartment. http://purl.obolibrary.org/obo/PBPKO_06026 unbound venous skin concentration http://purl.obolibrary.org/obo/PBPKO_06002 unbound venous concentration of compound in compartment The unbound venous concentration of compound in the skin compartment. http://purl.obolibrary.org/obo/PBPKO_06027 unbound venous mammary gland concentration http://purl.obolibrary.org/obo/PBPKO_06002 unbound venous concentration of compound in compartment The unbound venous concentration of compound in the mammary gland compartment. http://purl.obolibrary.org/obo/PBPKO_06028 unbound venous rest body concentration http://purl.obolibrary.org/obo/PBPKO_06002 unbound venous concentration of compound in compartment The unbound venous concentration of compound in the rest body compartment. http://purl.obolibrary.org/obo/PBPKO_06030 total venous liver concentration http://purl.obolibrary.org/obo/PBPKO_06029 total venous concentration of compound in compartment The total venous concentration of compound in the liver compartment. http://purl.obolibrary.org/obo/PBPKO_06031 total venous gut concentration http://purl.obolibrary.org/obo/PBPKO_06029 total venous concentration of compound in compartment The total venous concentration of compound in the gut compartment. http://purl.obolibrary.org/obo/PBPKO_06032 total venous kidney concentration http://purl.obolibrary.org/obo/PBPKO_06029 total venous concentration of compound in compartment The total venous concentration of compound in the kidney compartment. http://purl.obolibrary.org/obo/PBPKO_06033 total venous brain concentration http://purl.obolibrary.org/obo/PBPKO_06029 total venous concentration of compound in compartment The total venous concentration of compound in the brain compartment. http://purl.obolibrary.org/obo/PBPKO_06034 total venous filtrate concentration http://purl.obolibrary.org/obo/PBPKO_06029 total venous concentration of compound in compartment The total venous concentration of compound in the filtrate compartment. http://purl.obolibrary.org/obo/PBPKO_06035 total venous lung concentration http://purl.obolibrary.org/obo/PBPKO_06029 total venous concentration of compound in compartment The total venous concentration of compound in the lung compartment. http://purl.obolibrary.org/obo/PBPKO_06036 total venous fat concentration http://purl.obolibrary.org/obo/PBPKO_06029 total venous concentration of compound in compartment The total venous concentration of compound in the fat compartment. http://purl.obolibrary.org/obo/PBPKO_06037 total venous bone marrow concentration http://purl.obolibrary.org/obo/PBPKO_06029 total venous concentration of compound in compartment The total venous concentration of compound in the bone marrow compartment. http://purl.obolibrary.org/obo/PBPKO_06038 total venous skin concentration http://purl.obolibrary.org/obo/PBPKO_06029 total venous concentration of compound in compartment The total venous concentration of compound in the skin compartment. http://purl.obolibrary.org/obo/PBPKO_06039 total venous mammary gland concentration http://purl.obolibrary.org/obo/PBPKO_06029 total venous concentration of compound in compartment The total venous concentration of compound in the mammary gland compartment. http://purl.obolibrary.org/obo/PBPKO_06040 total venous rest body concentration http://purl.obolibrary.org/obo/PBPKO_06029 total venous concentration of compound in compartment The total venous concentration of compound in the rest of the body compartment. http://purl.obolibrary.org/obo/PBPKO_06041 concentration in stomach http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The concentration of chemical in stomach compartment. http://purl.obolibrary.org/obo/PBPKO_06042 concentration in small intestine http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The concentration of chemical in small intestine compartment. http://purl.obolibrary.org/obo/PBPKO_06043 concentration in jejunum http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The concentration of chemical in jejunum compartment. http://purl.obolibrary.org/obo/PBPKO_06044 concentration in ileum http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The concentration of chemical in ileum compartment. http://purl.obolibrary.org/obo/PBPKO_06045 concentration in large intestine http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The concentration of chemical in large intestine compartment. http://purl.obolibrary.org/obo/PBPKO_06048 concentration in bile http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The concentration of chemical in bile. http://purl.obolibrary.org/obo/PBPKO_06049 concentration in spleen http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The concentration of chemical in spleen compartment. http://purl.obolibrary.org/obo/PBPKO_06050 concentration in feces http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment The concentration of chemical in feces. http://purl.obolibrary.org/obo/PBPKO_06052 maximum amount http://purl.obolibrary.org/obo/PBPKO_00252 output parameter The maximum amount of chemical in a compartment http://purl.obolibrary.org/obo/PBPKO_06062 amount in menstrual http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the menstrual compartment. http://purl.obolibrary.org/obo/PBPKO_06063 amount in kidney rest tissue http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the kidney rest tissue compartment. http://purl.obolibrary.org/obo/PBPKO_06065 amount in kidney proximal tubule tissue http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the proximal tubule tissue of kidney compartment. http://purl.obolibrary.org/obo/PBPKO_06066 amount in kidney proximal tubule lumen http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the proximal tubule lumen of kidney compartment. http://purl.obolibrary.org/obo/PBPKO_06067 amount in liver intracellular http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the intracellular spaceof liver compartment. http://purl.obolibrary.org/obo/PBPKO_06068 amount in liver extracellular http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment The amount of compound in the extracellular space of liver compartment. http://purl.obolibrary.org/obo/BFO_0000031 generically dependent continuant http://purl.obolibrary.org/obo/BFO_0000002 continuant http://purl.obolibrary.org/obo/BFO_0000141 immaterial entity http://purl.obolibrary.org/obo/BFO_0000004 independent continuant http://purl.obolibrary.org/obo/BFO_0000034 function http://purl.obolibrary.org/obo/BFO_0000016 disposition http://purl.obolibrary.org/obo/BFO_0000016 disposition http://purl.obolibrary.org/obo/BFO_0000017 realizable entity http://purl.obolibrary.org/obo/PATO_0000001 quality http://purl.obolibrary.org/obo/BFO_0000020 specifically dependent continuant http://purl.obolibrary.org/obo/BFO_0000019 quality http://purl.obolibrary.org/obo/BFO_0000020 specifically dependent continuant http://purl.obolibrary.org/obo/BFO_0000029 site http://purl.obolibrary.org/obo/BFO_0000141 immaterial entity http://purl.obolibrary.org/obo/UO_0000001 length unit http://purl.obolibrary.org/obo/IAO_0000003 measurement unit label http://purl.obolibrary.org/obo/UO_0000002 mass unit http://purl.obolibrary.org/obo/IAO_0000003 measurement unit label http://purl.obolibrary.org/obo/UO_0000003 time unit http://purl.obolibrary.org/obo/IAO_0000003 measurement unit label http://purl.obolibrary.org/obo/UO_0000005 temperature unit http://purl.obolibrary.org/obo/IAO_0000003 measurement unit label http://purl.obolibrary.org/obo/UO_0000006 substance unit http://purl.obolibrary.org/obo/IAO_0000003 measurement unit label http://purl.obolibrary.org/obo/UO_0000051 concentration unit http://purl.obolibrary.org/obo/IAO_0000003 measurement unit label http://purl.obolibrary.org/obo/UO_0000095 volume unit http://purl.obolibrary.org/obo/IAO_0000003 measurement unit label http://purl.obolibrary.org/obo/UO_0000105 frequency unit http://purl.obolibrary.org/obo/IAO_0000003 measurement unit label http://purl.obolibrary.org/obo/UO_0000270 volumetric flow rate unit http://purl.obolibrary.org/obo/IAO_0000003 measurement unit label http://purl.obolibrary.org/obo/UO_0000280 rate unit http://purl.obolibrary.org/obo/IAO_0000003 measurement unit label http://purl.obolibrary.org/obo/NCBITaxon_32523 Tetrapoda http://purl.obolibrary.org/obo/NCBITaxon_117571 Euteleostomi http://purl.obolibrary.org/obo/NCBITaxon_33154 Opisthokonta http://purl.obolibrary.org/obo/NCBITaxon_2759 Eukaryota http://purl.obolibrary.org/obo/NCBITaxon_9606 Homo sapiens http://purl.obolibrary.org/obo/NCBITaxon_314146 Euarchontoglires http://purl.obolibrary.org/obo/NCBITaxon_32524 Amniota http://purl.obolibrary.org/obo/NCBITaxon_32523 Tetrapoda http://purl.obolibrary.org/obo/NCBITaxon_40674 Mammalia http://purl.obolibrary.org/obo/NCBITaxon_32524 Amniota http://purl.obolibrary.org/obo/NCBITaxon_33208 Metazoa http://purl.obolibrary.org/obo/NCBITaxon_33154 Opisthokonta http://purl.obolibrary.org/obo/NCBITaxon_33213 Bilateria http://purl.obolibrary.org/obo/NCBITaxon_33208 Metazoa http://purl.obolibrary.org/obo/NCBITaxon_7742 Vertebrata http://purl.obolibrary.org/obo/NCBITaxon_33213 Bilateria http://purl.obolibrary.org/obo/NCBITaxon_314146 Euarchontoglires http://purl.obolibrary.org/obo/NCBITaxon_40674 Mammalia http://purl.obolibrary.org/obo/NCBITaxon_117571 Euteleostomi http://purl.obolibrary.org/obo/NCBITaxon_7742 Vertebrata http://purl.obolibrary.org/obo/NCBITaxon_2759 Eukaryota http://purl.obolibrary.org/obo/COB_0000022 organism http://purl.obolibrary.org/obo/GO_0007588 excretion http://purl.obolibrary.org/obo/GO_0003008 system process http://purl.obolibrary.org/obo/GO_0016301 kinase activity http://purl.obolibrary.org/obo/GO_0003674 gene product or complex activity http://purl.obolibrary.org/obo/GO_0009987 cellular process http://purl.obolibrary.org/obo/GO_0008150 biological process http://purl.obolibrary.org/obo/GO_0032501 multicellular organismal process http://purl.obolibrary.org/obo/GO_0008150 biological process http://purl.obolibrary.org/obo/GO_0008152 metabolic process http://purl.obolibrary.org/obo/GO_0009987 cellular process http://purl.obolibrary.org/obo/GO_0003008 system process http://purl.obolibrary.org/obo/GO_0032501 multicellular organismal process http://purl.obolibrary.org/obo/COB_0000035 completely executed planned process http://purl.obolibrary.org/obo/COB_0000082 planned process http://purl.obolibrary.org/obo/PBPKO_03015 kinetic emptying rate between intestinal segments http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03049 linear metabolic rate http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03005 intrinsic fecal excretion rate http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03006 fecal excretion rate http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03007 intrinsic biliary clearance rate http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03008 kinetic emptying rate from jejunum lumen to ileum lumen http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03009 kinetic emptying rate from ileum lumen to large intestine lumen http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03010 kinetic absorption rate from jejunum lumen to intestinal tissue http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03011 kinetic absorption rate from ileum lumen to intestinal tissue http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03012 kinetic absorption rate from large intestinal lumen to intestinal tissue http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03013 effective Caco-2 permeability http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03014 apparent Caco-2 permeability http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03016 Hill dissociation constant http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03017 Hill coefficient http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03018 intrinsic absorption rate of metabilite http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03019 absorption rate of metabolite http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03020 intrinsic enterohepatic recirculation rate constant http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03021 enterohepatic recirculation rate constant http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03023 intrinsic reabsorption rate constant http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03024 reabsorption rate constant http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03025 maximum capacity of binding sites in red cells http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03026 half-saturation concentration of chemical for binding by sites in red cells http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03027 metabolism rate constant in liver http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03028 metabolism rate constant in intestinal tissue http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03030 red blood cells partition coefficient http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03045 abiotic degradation rate in medium http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03046 acidic phospholipid association constant http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03047 abiotic degradation rate in air http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03048 maximum metabolic rate http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03050 cell radius http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03051 cell replication time http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03052 cell fraction of proteins http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03053 cell fraction of lipids http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03054 cell fraction of intracellular water http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03055 cell fraction of mitochondria http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03056 cell fraction of lysosomes http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03057 cell fraction of microsomes http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03058 fraction of neutral lipids in the FBS http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03059 fraction of albumin in the FBS http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03060 culture area http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03061 top well diameter http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03062 well depth http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03063 plate wall thickness http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03064 culture medium pH http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03065 fraction of serum in total media http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03066 FBS pH http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03067 initial number of cells http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03068 nominal concentration of medium http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03069 volume of medium http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03070 fraction of FBS iin the medium http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_03071 ionized fraction in the medium http://purl.obolibrary.org/obo/PBPKO_00139 biochemical parameter http://purl.obolibrary.org/obo/PBPKO_07001 invitro pbpk http://purl.obolibrary.org/obo/PBPKO_00003 physiologically based pharmacokinetic model http://purl.obolibrary.org/obo/PBPKO_04050 surface area of the jejunum lumen http://purl.obolibrary.org/obo/PBPKO_00010 surface area http://purl.obolibrary.org/obo/PBPKO_04051 surface area of the ileum lumen http://purl.obolibrary.org/obo/PBPKO_00010 surface area http://purl.obolibrary.org/obo/PBPKO_04052 surface area of the large intestine lumen http://purl.obolibrary.org/obo/PBPKO_00010 surface area http://purl.obolibrary.org/obo/PBPKO_04046 diameter of intestinal http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter http://purl.obolibrary.org/obo/PBPKO_04047 diameter of the jejunum lumen http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter http://purl.obolibrary.org/obo/PBPKO_04048 diameter of the ileum lumen http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter http://purl.obolibrary.org/obo/PBPKO_04049 diameter of the large intestine lumen http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter http://purl.obolibrary.org/obo/PBPKO_04053 uptake fraction to blood http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter http://purl.obolibrary.org/obo/PBPKO_04057 volume fraction of blood http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter http://purl.obolibrary.org/obo/PBPKO_04058 volume fraction of red blood cells http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter http://purl.obolibrary.org/obo/PBPKO_04059 skin area http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter http://purl.obolibrary.org/obo/PBPKO_04063 area of exposed skin http://purl.obolibrary.org/obo/PBPKO_00006 physiological parameter http://purl.obolibrary.org/obo/PBPKO_04039 blood flow rate to red blood cells http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment http://purl.obolibrary.org/obo/PBPKO_04044 hepatic vein blood flow http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment http://purl.obolibrary.org/obo/PBPKO_04045 blood flow rate to bile http://purl.obolibrary.org/obo/PBPKO_00012 blood flow rate to compartment http://purl.obolibrary.org/obo/PBPKO_04038 fraction of blood flow to red blood cells http://purl.obolibrary.org/obo/PBPKO_00611 fraction of blood flow to a compartment http://purl.obolibrary.org/obo/PBPKO_04086 fraction of intestinal lumen http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment http://purl.obolibrary.org/obo/PBPKO_04054 fraction of bile in small intestine http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment http://purl.obolibrary.org/obo/PBPKO_04055 fraction of bile in liver http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment http://purl.obolibrary.org/obo/PBPKO_04056 fraction of feces http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment http://purl.obolibrary.org/obo/PBPKO_04082 fraction of serum http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment http://purl.obolibrary.org/obo/PBPKO_04083 fraction of adrenals http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment http://purl.obolibrary.org/obo/PBPKO_04084 fraction of breast http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment http://purl.obolibrary.org/obo/PBPKO_04085 fraction of thyroid http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment http://purl.obolibrary.org/obo/PBPKO_04087 fraction of small intestinal lumen http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment http://purl.obolibrary.org/obo/PBPKO_04088 fraction of large intestinal lumen http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment http://purl.obolibrary.org/obo/PBPKO_04089 fraction of stomach lumen http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment http://purl.obolibrary.org/obo/PBPKO_04090 fraction of gut intestinal tract http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment http://purl.obolibrary.org/obo/PBPKO_04091 fraction of testis http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment http://purl.obolibrary.org/obo/PBPKO_04092 fraction of uterus http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment http://purl.obolibrary.org/obo/PBPKO_04093 fraction of skeleton http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment http://purl.obolibrary.org/obo/PBPKO_04094 fraction of hair http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment http://purl.obolibrary.org/obo/PBPKO_04095 fraction of amniotic fluid http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment http://purl.obolibrary.org/obo/PBPKO_04096 fraction of urinary tract http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment http://purl.obolibrary.org/obo/PBPKO_04097 fraction of cortical bone http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment http://purl.obolibrary.org/obo/PBPKO_04098 fraction of trabecular bone http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment http://purl.obolibrary.org/obo/PBPKO_04099 fraction of the skin surface depot http://purl.obolibrary.org/obo/PBPKO_00610 fraction of volume of compartment http://purl.obolibrary.org/obo/PBPKO_04068 volume of intestinal lumen http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_04040 volumen of lumen http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_04041 volume of small intestine tissue http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_04042 volume of bile http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_04043 enterocyte volume http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_04061 volume of exposed viable epidermis http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_04062 volume of follicle http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_04064 volume of serum http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_04065 volume of adrenals http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_04066 volume of breast http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_04067 volume of thyroid http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_04069 volume of small intestinal lumen http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_04070 volume of large intestinal lumen http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_04071 volume of stomach lumen http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_04072 volume of gut intestinal tract http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_04073 volume of testis http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_04074 volume of uterus http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_04075 volume of skeleton http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_04076 volume of hair http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_04077 volume of urinary tract http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_04078 volume of skin surface depot http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_04079 volume of cortical bone http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_04080 volume of trabecular bone http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_04081 volume of alveolar compartment http://purl.obolibrary.org/obo/PBPKO_00066 volume of compartment http://purl.obolibrary.org/obo/PBPKO_03072 fraction unbound in the medium http://purl.obolibrary.org/obo/PBPKO_00149 unbound fraction http://purl.obolibrary.org/obo/PBPKO_03073 fraction unbound in the FBS http://purl.obolibrary.org/obo/PBPKO_00149 unbound fraction http://purl.obolibrary.org/obo/PBPKO_03074 fraction unbound in the cell http://purl.obolibrary.org/obo/PBPKO_00149 unbound fraction http://purl.obolibrary.org/obo/PBPKO_03031 follicle permeability coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient http://purl.obolibrary.org/obo/PBPKO_03032 partition coeffcient of stratum corneum to viable epidermis http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient http://purl.obolibrary.org/obo/PBPKO_03033 partition coeffcient of viable epidermis to blood http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient http://purl.obolibrary.org/obo/PBPKO_03034 partition coeffcient of stratum corneum to skin surface depot http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient http://purl.obolibrary.org/obo/PBPKO_03035 partition coeffcient of follicle to skin surface depot http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient http://purl.obolibrary.org/obo/PBPKO_03036 octanol water partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient http://purl.obolibrary.org/obo/PBPKO_03037 medium polymer partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient http://purl.obolibrary.org/obo/PBPKO_03038 medium air partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient http://purl.obolibrary.org/obo/PBPKO_03039 medium mitochondria partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient http://purl.obolibrary.org/obo/PBPKO_03040 medium lysosomes partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient http://purl.obolibrary.org/obo/PBPKO_03041 medium intracellular water partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient http://purl.obolibrary.org/obo/PBPKO_03042 medium microsomes partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient http://purl.obolibrary.org/obo/PBPKO_03043 medium other organelles partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient http://purl.obolibrary.org/obo/PBPKO_03044 medium albumin partition coefficient http://purl.obolibrary.org/obo/PBPKO_00165 partition coefficient http://purl.obolibrary.org/obo/PBPKO_01501 pgp http://purl.obolibrary.org/obo/PBPKO_00217 transporter http://purl.obolibrary.org/obo/PBPKO_01502 mrp2 http://purl.obolibrary.org/obo/PBPKO_00217 transporter http://purl.obolibrary.org/obo/PBPKO_01503 mrp4 http://purl.obolibrary.org/obo/PBPKO_00217 transporter http://purl.obolibrary.org/obo/PBPKO_01504 bcrp http://purl.obolibrary.org/obo/PBPKO_00217 transporter http://purl.obolibrary.org/obo/PBPKO_01505 nctp http://purl.obolibrary.org/obo/PBPKO_00217 transporter http://purl.obolibrary.org/obo/PBPKO_01506 oct1 http://purl.obolibrary.org/obo/PBPKO_00217 transporter http://purl.obolibrary.org/obo/PBPKO_01507 oat1 http://purl.obolibrary.org/obo/PBPKO_00217 transporter http://purl.obolibrary.org/obo/PBPKO_01508 oat3 http://purl.obolibrary.org/obo/PBPKO_00217 transporter http://purl.obolibrary.org/obo/PBPKO_01509 oat4 http://purl.obolibrary.org/obo/PBPKO_00217 transporter http://purl.obolibrary.org/obo/PBPKO_06051 amount in skin surface depot http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment http://purl.obolibrary.org/obo/PBPKO_06053 amount in follicles http://purl.obolibrary.org/obo/PBPKO_00615 amount of compound in compartment http://purl.obolibrary.org/obo/PBPKO_06003 unbound concentration of compund in compartment http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment http://purl.obolibrary.org/obo/PBPKO_06029 total venous concentration of compound in compartment http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment http://purl.obolibrary.org/obo/PBPKO_06054 concentration in medium http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment http://purl.obolibrary.org/obo/PBPKO_06055 concentration in cell http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment http://purl.obolibrary.org/obo/PBPKO_06056 concentration in mitochondria http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment http://purl.obolibrary.org/obo/PBPKO_06057 concentration in lysosomes http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment http://purl.obolibrary.org/obo/PBPKO_06058 concentration in microsomes http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment http://purl.obolibrary.org/obo/PBPKO_06059 concentration in intracellular water http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment http://purl.obolibrary.org/obo/PBPKO_06060 concentration in polymer http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment http://purl.obolibrary.org/obo/PBPKO_06061 concentration in air http://purl.obolibrary.org/obo/PBPKO_00616 concentration of compound in compartment http://purl.obolibrary.org/obo/PBPKO_04060 thickness epidermis http://purl.obolibrary.org/obo/PBPKO_00635 skin thickness http://purl.obolibrary.org/obo/PBPKO_06002 unbound venous concentration of compound in compartment http://purl.obolibrary.org/obo/PBPKO_06003 unbound concentration of compund in compartment http://purl.obolibrary.org/obo/BFO_0000003 occurrent An entity that has temporal parts and that happens, unfolds or develops through time. http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. http://purl.obolibrary.org/obo/BFO_0000001 entity http://purl.obolibrary.org/obo/COB_0000502 characteristic http://purl.obolibrary.org/obo/RO_0000052 characteristic of http://purl.obolibrary.org/obo/RO_0002314 characteristic of part of inheres_in a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence. http://purl.obolibrary.org/obo/RO_0000079 function of http://purl.obolibrary.org/obo/RO_0000052 characteristic of is function of a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0000080 quality of http://purl.obolibrary.org/obo/RO_0000052 characteristic of quality_of a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0000085 has function http://purl.obolibrary.org/obo/RO_0000053 has characteristic has_function a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0000086 has quality http://purl.obolibrary.org/obo/RO_0000053 has characteristic has_quality a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0000087 has role http://purl.obolibrary.org/obo/RO_0000053 has characteristic has_role a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0000081 role of http://purl.obolibrary.org/obo/RO_0000052 characteristic of role_of a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/BFO_0000063 precedes http://purl.obolibrary.org/obo/RO_0002222 temporally related to x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. http://purl.obolibrary.org/obo/OBI_0000293 has specified input http://purl.obolibrary.org/obo/RO_0000057 has participant The inverse property of is specified input of http://purl.obolibrary.org/obo/OBI_0000295 is specified input of http://purl.obolibrary.org/obo/RO_0000056 participates in A relation between a completely executed planned process and a continuant participating in that process that is not created during the process. The presence of the continuant during the process is explicitly specified in the plan specification which the process realizes the concretization of. http://purl.obolibrary.org/obo/OBI_0000299 has specified output http://purl.obolibrary.org/obo/RO_0000057 has participant The inverse property of is specified output of http://purl.obolibrary.org/obo/OBI_0000312 is specified output of http://purl.obolibrary.org/obo/RO_0000056 participates in A relation between a completely executed planned process and a continuant participating in that process. The presence of the continuant at the end of the process is explicitly specified in the objective specification which the process realizes the concretization of. http://purl.obolibrary.org/obo/RO_0002018 has component process http://purl.obolibrary.org/obo/RO_0002180 has component w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type. http://purl.obolibrary.org/obo/RO_0019000 regulates characteristic http://purl.obolibrary.org/obo/RO_0002410 causally related to A relationship that holds between a process and a characteristic in which process (P) regulates characteristic (C) iff: P results in the existence of C OR affects the intensity or magnitude of C. http://purl.obolibrary.org/obo/RO_0019001 positively regulates characteristic http://purl.obolibrary.org/obo/RO_0019000 regulates characteristic A relationship that holds between a process and a characteristic in which process (P) positively regulates characteristic (C) iff: P results in an increase in the intensity or magnitude of C. http://purl.obolibrary.org/obo/RO_0019002 negatively regulates characteristic http://purl.obolibrary.org/obo/RO_0019000 regulates characteristic A relationship that holds between a process and a characteristic in which process (P) negatively regulates characteristic (C) iff: P results in a decrease in the intensity or magnitude of C. http://purl.obolibrary.org/obo/BFO_0000051 has part http://purl.obolibrary.org/obo/RO_0002131 overlaps a core relation that holds between a whole and its part http://purl.obolibrary.org/obo/RO_0002327 enables http://purl.obolibrary.org/obo/RO_0002215 capable of c enables p iff c is capable of p and c acts to execute p. http://purl.obolibrary.org/obo/RO_0002333 enabled by http://purl.obolibrary.org/obo/RO_0002328 functionally related to inverse of enables http://purl.obolibrary.org/obo/RO_0002404 causally downstream of http://purl.obolibrary.org/obo/RO_0002427 causally downstream of or within inverse of upstream of http://purl.obolibrary.org/obo/RO_0002409 indirectly negatively regulates http://purl.obolibrary.org/obo/RO_0012012 indirectly regulates p indirectly negatively regulates q iff p is indirectly causally upstream of q and p negatively regulates q. http://purl.obolibrary.org/obo/RO_0002412 immediately causally upstream of http://purl.obolibrary.org/obo/RO_0002411 causally upstream of p is immediately causally upstream of q iff p is causally upstream of q, and the end of p is coincident with the beginning of q. http://purl.obolibrary.org/obo/RO_0002436 molecularly interacts with http://purl.obolibrary.org/obo/RO_0002434 interacts with An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other. http://purl.obolibrary.org/obo/RO_0002448 directly regulates activity of http://purl.obolibrary.org/obo/RO_0011002 regulates activity of The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B. A and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B. http://purl.obolibrary.org/obo/RO_0002449 directly negatively regulates activity of http://purl.obolibrary.org/obo/RO_0002448 directly regulates activity of The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B. http://purl.obolibrary.org/obo/RO_0002566 causally influences http://purl.obolibrary.org/obo/RO_0002506 causal relation between entities The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size). http://purl.obolibrary.org/obo/RO_0002263 acts upstream of http://purl.obolibrary.org/obo/RO_0002264 acts upstream of or within c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes. http://purl.obolibrary.org/obo/RO_0002304 causally upstream of, positive effect http://purl.obolibrary.org/obo/RO_0004047 causally upstream of or within, positive effect p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q. http://purl.obolibrary.org/obo/RO_0002305 causally upstream of, negative effect http://purl.obolibrary.org/obo/RO_0004046 causally upstream of or within, negative effect p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q. http://purl.obolibrary.org/obo/RO_0002131 overlaps http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to x overlaps y if and only if there exists some z such that x has part z and z part of y http://purl.obolibrary.org/obo/RO_0000091 has disposition http://purl.obolibrary.org/obo/RO_0000053 has characteristic a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0000092 disposition of http://purl.obolibrary.org/obo/RO_0000052 characteristic of inverse of has disposition http://purl.obolibrary.org/obo/RO_0011002 regulates activity of http://purl.obolibrary.org/obo/RO_0002566 causally influences The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B. http://purl.obolibrary.org/obo/BFO_0000062 preceded by http://purl.obolibrary.org/obo/RO_0002086 ends after x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. http://purl.obolibrary.org/obo/RO_0002411 causally upstream of http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q. http://purl.obolibrary.org/obo/BFO_0000050 part of http://purl.obolibrary.org/obo/RO_0002131 overlaps a core relation that holds between a part and its whole http://purl.obolibrary.org/obo/RO_0002211 regulates http://purl.obolibrary.org/obo/RO_0002411 causally upstream of p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q. http://purl.obolibrary.org/obo/RO_0002212 negatively regulates http://purl.obolibrary.org/obo/RO_0002211 regulates p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q. http://purl.obolibrary.org/obo/RO_0002213 positively regulates http://purl.obolibrary.org/obo/RO_0002211 regulates p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q. http://purl.obolibrary.org/obo/RO_0002180 has component http://purl.obolibrary.org/obo/BFO_0000051 has part w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type. http://purl.obolibrary.org/obo/RO_0002233 has input http://purl.obolibrary.org/obo/RO_0000057 has participant p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p. http://purl.obolibrary.org/obo/RO_0002314 characteristic of part of http://purl.obolibrary.org/obo/RO_0002502 depends on q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w. http://purl.obolibrary.org/obo/RO_0002352 input of http://purl.obolibrary.org/obo/RO_0002328 functionally related to inverse of has input http://purl.obolibrary.org/obo/RO_0002215 capable of http://purl.obolibrary.org/obo/RO_0002216 capable of part of A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. http://purl.obolibrary.org/obo/RO_0012011 indirectly causally upstream of http://purl.obolibrary.org/obo/RO_0002411 causally upstream of p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q. http://purl.obolibrary.org/obo/RO_0012012 indirectly regulates http://purl.obolibrary.org/obo/RO_0012011 indirectly causally upstream of p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q. http://purl.obolibrary.org/obo/RO_0002264 acts upstream of or within http://purl.obolibrary.org/obo/RO_0002500 causal agent in process c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process. http://purl.obolibrary.org/obo/RO_0002331 involved in http://purl.obolibrary.org/obo/RO_0002431 involved in or involved in regulation of c involved_in p if and only if c enables some process p', and p' is part of p http://purl.obolibrary.org/obo/RO_0002431 involved in or involved in regulation of http://purl.obolibrary.org/obo/RO_0002500 causal agent in process c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p http://purl.obolibrary.org/obo/RO_0004031 enables subfunction http://purl.obolibrary.org/obo/RO_0002328 functionally related to Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P. http://purl.obolibrary.org/obo/RO_0004034 acts upstream of, positive effect http://purl.obolibrary.org/obo/RO_0004032 acts upstream of or within, positive effect c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive http://purl.obolibrary.org/obo/RO_0004035 acts upstream of, negative effect http://purl.obolibrary.org/obo/RO_0004033 acts upstream of or within, negative effect c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative http://purl.obolibrary.org/obo/RO_0002216 capable of part of http://purl.obolibrary.org/obo/RO_0002500 causal agent in process c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p. http://purl.obolibrary.org/obo/RO_0002329 part of structure that is capable of http://purl.obolibrary.org/obo/RO_0002328 functionally related to this relation holds between c and p when c is part of some c', and c' is capable of p. http://purl.obolibrary.org/obo/RO_0002334 regulated by http://purl.obolibrary.org/obo/RO_0002427 causally downstream of or within inverse of regulates http://purl.obolibrary.org/obo/RO_0002335 negatively regulated by http://purl.obolibrary.org/obo/RO_0002334 regulated by inverse of negatively regulates http://purl.obolibrary.org/obo/RO_0002336 positively regulated by http://purl.obolibrary.org/obo/RO_0002334 regulated by inverse of positively regulates http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within http://purl.obolibrary.org/obo/RO_0002501 causal relation between processes p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q. http://purl.obolibrary.org/obo/RO_0002427 causally downstream of or within http://purl.obolibrary.org/obo/RO_0002501 causal relation between processes inverse of causally upstream of or within http://purl.obolibrary.org/obo/RO_0002500 causal agent in process http://purl.obolibrary.org/obo/RO_0002595 causal relation between material entity and a process A relationship between a material entity and a process where the material entity has some causal role that influences the process http://purl.obolibrary.org/obo/RO_0002501 causal relation between processes http://purl.obolibrary.org/obo/RO_0002410 causally related to p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q. http://purl.obolibrary.org/obo/RO_0002584 has part structure that is capable of http://purl.obolibrary.org/obo/RO_0002595 causal relation between material entity and a process s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p http://purl.obolibrary.org/obo/RO_0002595 causal relation between material entity and a process http://purl.obolibrary.org/obo/RO_0002410 causally related to A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity. http://purl.obolibrary.org/obo/RO_0002596 capable of regulating http://purl.obolibrary.org/obo/RO_0002500 causal agent in process Holds between c and p if and only if c is capable of some activity a, and a regulates p. http://purl.obolibrary.org/obo/RO_0002597 capable of negatively regulating http://purl.obolibrary.org/obo/RO_0002596 capable of regulating Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p. http://purl.obolibrary.org/obo/RO_0002598 capable of positively regulating http://purl.obolibrary.org/obo/RO_0002596 capable of regulating Holds between c and p if and only if c is capable of some activity a, and a positively regulates p. http://purl.obolibrary.org/obo/RO_0002608 process has causal agent http://purl.obolibrary.org/obo/RO_0002410 causally related to Inverse of 'causal agent in process' http://purl.obolibrary.org/obo/RO_0002015 has positive regulatory component activity http://purl.obolibrary.org/obo/RO_0002013 has regulatory component activity A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B. http://purl.obolibrary.org/obo/RO_0002013 has regulatory component activity http://purl.obolibrary.org/obo/RO_0002017 has component activity A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B. http://purl.obolibrary.org/obo/RO_0002014 has negative regulatory component activity http://purl.obolibrary.org/obo/RO_0002013 has regulatory component activity A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B. http://purl.obolibrary.org/obo/RO_0002407 indirectly positively regulates http://purl.obolibrary.org/obo/RO_0012012 indirectly regulates p indirectly positively regulates q iff p is indirectly causally upstream of q and p positively regulates q. http://purl.obolibrary.org/obo/RO_0002428 involved in regulation of http://purl.obolibrary.org/obo/RO_0002431 involved in or involved in regulation of c involved in regulation of p if c is involved in some p' and p' regulates some p http://purl.obolibrary.org/obo/RO_0002429 involved in positive regulation of http://purl.obolibrary.org/obo/RO_0002428 involved in regulation of c involved in regulation of p if c is involved in some p' and p' positively regulates some p http://purl.obolibrary.org/obo/RO_0002430 involved in negative regulation of http://purl.obolibrary.org/obo/RO_0002428 involved in regulation of c involved in regulation of p if c is involved in some p' and p' negatively regulates some p http://purl.obolibrary.org/obo/RO_0002450 directly positively regulates activity of http://purl.obolibrary.org/obo/RO_0002448 directly regulates activity of The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B. http://purl.obolibrary.org/obo/RO_0002578 directly regulates http://purl.obolibrary.org/obo/RO_0002211 regulates p directly regulates q iff p is immediately causally upstream of q and p regulates q. http://purl.obolibrary.org/obo/RO_0002629 directly positively regulates http://purl.obolibrary.org/obo/RO_0002578 directly regulates p directly positively regulates q iff p is immediately causally upstream of q, and p positively regulates q. http://purl.obolibrary.org/obo/RO_0002630 directly negatively regulates http://purl.obolibrary.org/obo/RO_0002578 directly regulates p directly negatively regulates q iff p is immediately causally upstream of q, and p negatively regulates q. http://purl.obolibrary.org/obo/RO_0002090 immediately precedes http://purl.obolibrary.org/obo/BFO_0000063 precedes http://purl.obolibrary.org/obo/RO_0002405 immediately causally downstream of http://purl.obolibrary.org/obo/RO_0002404 causally downstream of http://purl.obolibrary.org/obo/RO_0002017 has component activity http://purl.obolibrary.org/obo/RO_0002018 has component process http://purl.obolibrary.org/obo/RO_0002447 phosphorylates http://purl.obolibrary.org/obo/RO_0002436 molecularly interacts with http://purl.obolibrary.org/obo/RO_0002559 causally influenced by http://purl.obolibrary.org/obo/RO_0002506 causal relation between entities http://purl.obolibrary.org/obo/RO_0002563 interaction relation helper property http://purl.obolibrary.org/obo/RO_0002464 helper property (not for use in curation) http://purl.obolibrary.org/obo/RO_0002564 molecular interaction relation helper property http://purl.obolibrary.org/obo/RO_0002563 interaction relation helper property http://purl.obolibrary.org/obo/RO_0002481 is kinase activity http://purl.obolibrary.org/obo/RO_0002564 molecular interaction relation helper property http://purl.obolibrary.org/obo/RO_0002087 immediately preceded by http://purl.obolibrary.org/obo/BFO_0000062 preceded by http://purl.obolibrary.org/obo/RO_0002086 ends after http://purl.obolibrary.org/obo/RO_0002222 temporally related to http://purl.obolibrary.org/obo/RO_0002023 directly negatively regulated by http://purl.obolibrary.org/obo/RO_0002022 directly regulated by http://purl.obolibrary.org/obo/RO_0002024 directly positively regulated by http://purl.obolibrary.org/obo/RO_0002022 directly regulated by http://purl.obolibrary.org/obo/RO_0004033 acts upstream of or within, negative effect http://purl.obolibrary.org/obo/RO_0002264 acts upstream of or within http://purl.obolibrary.org/obo/RO_0004032 acts upstream of or within, positive effect http://purl.obolibrary.org/obo/RO_0002264 acts upstream of or within http://purl.obolibrary.org/obo/RO_0002022 directly regulated by http://purl.obolibrary.org/obo/RO_0002334 regulated by http://purl.obolibrary.org/obo/RO_0002506 causal relation between entities http://purl.obolibrary.org/obo/RO_0002410 causally related to http://purl.obolibrary.org/obo/RO_0004046 causally upstream of or within, negative effect http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within http://purl.obolibrary.org/obo/RO_0004047 causally upstream of or within, positive effect http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within http://purl.obolibrary.org/obo/RO_0002025 has effector activity http://purl.obolibrary.org/obo/RO_0002017 has component activity http://purl.obolibrary.org/obo/RO_0000053 has characteristic is bearer of Inverse of characteristic_of http://purl.obolibrary.org/obo/BFO_0000055 realizes Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process http://purl.obolibrary.org/obo/IAO_0000136 is about A (currently) primitive relation that relates an information artifact to an entity. http://purl.obolibrary.org/obo/OBI_0000417 achieves_planned_objective This relation obtains between a planned process and a objective specification when the criteria specified in the objective specification are met at the end of the planned process. http://purl.obolibrary.org/obo/OBI_0000833 objective_achieved_by This relation obtains between an objective specification and a planned process when the criteria specified in the objective specification are met at the end of the planned process. http://purl.obolibrary.org/obo/RO_0000056 participates in a relation between a continuant and a process, in which the continuant is somehow involved in the process http://purl.obolibrary.org/obo/RO_0000057 has participant a relation between a process and a continuant, in which the continuant is somehow involved in the process http://purl.obolibrary.org/obo/RO_0000059 concretizes A relationship between a specifically dependent continuant and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. Multiple specifically dependent continuants can concretize the same generically dependent continuant. http://purl.obolibrary.org/obo/RO_0002351 has member has member is a mereological relation between a collection and an item. http://purl.obolibrary.org/obo/RO_0017001 device utilizes material X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y. http://purl.obolibrary.org/obo/RO_0002434 interacts with A relationship that holds between two entities in which the processes executed by the two entities are causally connected. http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to A mereological relationship or a topological relationship http://purl.obolibrary.org/obo/RO_0002328 functionally related to A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities. http://purl.obolibrary.org/obo/RO_0002464 helper property (not for use in curation) http://purl.obolibrary.org/obo/RO_0002222 temporally related to http://purl.obolibrary.org/obo/RO_0002502 depends on http://purl.obolibrary.org/obo/RO_0002410 causally related to