Term IRI Term label Parent term IRI Parent term label Alternative term Definition http://purl.obolibrary.org/obo/OBI_0000070 assay http://purl.obolibrary.org/obo/COB_0000035 completely executed planned process scientific observation A planned process that has the objective to produce information about a material entity (the evaluant) by examining it. http://purl.obolibrary.org/obo/PATO_0000001 quality http://purl.obolibrary.org/obo/BFO_0000020 specifically dependent continuant A dependent entity that inheres in a bearer by virtue of how the bearer is related to other entities http://purl.obolibrary.org/obo/PATO_0000402 branched http://purl.obolibrary.org/obo/PATO_0000001 quality A branchiness quality inhering in a bearer by virtue of the bearer's having branches. http://purl.obolibrary.org/obo/PATO_0001199 linear http://purl.obolibrary.org/obo/PATO_0000001 quality A shape quality inhering in a bearer by virtue of the bearer's being narrow, with the two opposite margins parallel. http://purl.obolibrary.org/obo/PATO_0001470 ratio http://purl.obolibrary.org/obo/PATO_0000001 quality A quality inhering in a bearer by virtue of the bearer's magnitude in proportion to the magnitude of another entity. http://purl.obolibrary.org/obo/PATO_0002124 laminar http://purl.obolibrary.org/obo/PATO_0000001 quality A quality inhering in a bearer by virtue of the bearer's processing the form of a thin plate sheet or layer. http://purl.obolibrary.org/obo/BFO_0000004 independent continuant http://purl.obolibrary.org/obo/BFO_0000002 continuant b is an independent continuant = Def. b is a continuant which is such that there is no c and no t such that b s-depends_on c at t. (axiom label in BFO2 Reference: [017-002]) http://purl.obolibrary.org/obo/BFO_0000015 process http://purl.obolibrary.org/obo/BFO_0000003 occurrent p is a process = Def. p is an occurrent that has temporal proper parts and for some time t, p s-depends_on some material entity at t. (axiom label in BFO2 Reference: [083-003]) http://purl.obolibrary.org/obo/BFO_0000017 realizable entity http://purl.obolibrary.org/obo/BFO_0000020 specifically dependent continuant A specifically dependent continuant that inheres in continuant entities and are not exhibited in full at every time in which it inheres in an entity or group of entities. The exhibition or actualization of a realizable entity is a particular manifestation, functioning or process that occurs under certain circumstances. http://purl.obolibrary.org/obo/BFO_0000020 specifically dependent continuant http://purl.obolibrary.org/obo/BFO_0000002 continuant b is a specifically dependent continuant = Def. b is a continuant & there is some independent continuant c which is not a spatial region and which is such that b s-depends_on c at every time t during the course of b’s existence. (axiom label in BFO2 Reference: [050-003]) http://purl.obolibrary.org/obo/BFO_0000023 role http://purl.obolibrary.org/obo/BFO_0000017 realizable entity A realizable entity the manifestation of which brings about some result or end that is not essential to a continuant in virtue of the kind of thing that it is but that can be served or participated in by that kind of continuant in some kinds of natural, social or institutional contexts. http://purl.obolibrary.org/obo/BFO_0000031 generically dependent continuant http://purl.obolibrary.org/obo/BFO_0000002 continuant b is a generically dependent continuant = Def. b is a continuant that g-depends_on one or more other entities. (axiom label in BFO2 Reference: [074-001]) http://purl.obolibrary.org/obo/BFO_0000040 material entity http://purl.obolibrary.org/obo/BFO_0000004 independent continuant An independent continuant that is spatially extended whose identity is independent of that of other entities and can be maintained through time. http://purl.obolibrary.org/obo/OGMS_0000031 disease http://purl.obolibrary.org/obo/BFO_0000016 disposition A disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism. http://purl.obolibrary.org/obo/CL_0000000 cell http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane. http://purl.obolibrary.org/obo/CL_0000101 sensory neuron http://purl.obolibrary.org/obo/CL_0000540 neuron Any neuron having a sensory function; an afferent neuron conveying sensory impulses. http://purl.obolibrary.org/obo/CL_0000540 neuron http://purl.obolibrary.org/obo/CL_0000000 cell The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system. http://purl.obolibrary.org/obo/UBERON_0001982 capillary http://purl.obolibrary.org/obo/UBERON_0001981 blood vessel Any of the smallest blood vessels connecting arterioles with venules. http://purl.obolibrary.org/obo/GO_0004842 ubiquitin-protein transferase activity http://purl.obolibrary.org/obo/GO_0003674 gene product or complex activity Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y = Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure http://purl.obolibrary.org/obo/UBERON_0000465 material anatomical entity Material anatomical entity that is a single connected structure with inherent 3D shape generated by coordinated expression of the organism's own genome. http://purl.obolibrary.org/obo/UBERON_0000122 neuron projection bundle http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure A fasciculated bundle of neuron projections (GO:0043005), largely or completely lacking synapses. http://purl.obolibrary.org/obo/UBERON_0000465 material anatomical entity http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity Anatomical entity that has mass. http://purl.obolibrary.org/obo/UBERON_0000466 immaterial anatomical entity http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity Anatomical entity that has no mass. http://purl.obolibrary.org/obo/UBERON_0001062 anatomical entity http://purl.obolibrary.org/obo/BFO_0000004 independent continuant Biological entity that is either an individual member of a biological species or constitutes the structural organization of an individual member of a biological species. http://purl.obolibrary.org/obo/UBERON_0001981 blood vessel http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure A vessel through which blood circulates in the body. http://purl.obolibrary.org/obo/UBERON_0010000 multicellular anatomical structure http://purl.obolibrary.org/obo/UBERON_0000061 anatomical structure An anatomical structure that has more than one cell as a part. http://purl.obolibrary.org/obo/RO_0002533 sequence atomic unit http://purl.obolibrary.org/obo/RO_0002532 sequentially ordered entity Any individual unit of a collection of like units arranged in a linear order http://purl.obolibrary.org/obo/RO_0002534 sequence bearer http://purl.obolibrary.org/obo/RO_0002532 sequentially ordered entity Any entity that can be divided into parts such that each part is an atomical unit of a sequence http://purl.obolibrary.org/obo/COB_0000022 organism http://purl.obolibrary.org/obo/UBERON_0000465 material anatomical entity A material entity that is a maximal functionally integrated unit that develops from a program encoded in a genome http://purl.obolibrary.org/obo/COB_0000026 processed material entity http://purl.obolibrary.org/obo/BFO_0000040 material entity A material entity processed by human activity with an intent to produce it. http://purl.obolibrary.org/obo/GO_0003674 gene product or complex activity http://purl.obolibrary.org/obo/BFO_0000015 process A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. http://purl.obolibrary.org/obo/GO_0008150 biological process http://purl.obolibrary.org/obo/BFO_0000015 process A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence. http://purl.obolibrary.org/obo/GO_0016301 kinase activity http://purl.obolibrary.org/obo/GO_0003674 gene product or complex activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. http://purl.obolibrary.org/obo/GO_0019107 myristoyltransferase activity http://purl.obolibrary.org/obo/GO_0003674 gene product or complex activity Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule. http://purl.obolibrary.org/obo/ENVO_01000254 environmental system http://purl.obolibrary.org/obo/RO_0002577 system A system which has the disposition to environ one or more material entities. http://purl.obolibrary.org/obo/RO_0002577 system http://purl.obolibrary.org/obo/BFO_0000040 material entity A material entity consisting of multiple components that are causally integrated. http://purl.obolibrary.org/obo/ENVO_01000739 habitat http://purl.obolibrary.org/obo/ENVO_01000254 environmental system An environmental system which can sustain and allow the growth of an ecological population. http://purl.obolibrary.org/obo/COB_0001000 exposure of organism http://purl.obolibrary.org/obo/BFO_0000015 process A process during which an organism comes into contact with another entity. http://purl.obolibrary.org/obo/COB_0001300 device http://purl.obolibrary.org/obo/COB_0000026 processed material entity A processed material entity which is designed to be capable of a process. http://purl.obolibrary.org/obo/UPHENO_0001001 phenotype http://purl.obolibrary.org/obo/PATO_0000001 quality http://purl.obolibrary.org/obo/BFO_0000141 immaterial entity http://purl.obolibrary.org/obo/BFO_0000004 independent continuant http://purl.obolibrary.org/obo/COB_0000035 completely executed planned process http://purl.obolibrary.org/obo/BFO_0000015 process http://purl.obolibrary.org/obo/BFO_0000034 function http://purl.obolibrary.org/obo/BFO_0000016 disposition http://purl.obolibrary.org/obo/BFO_0000016 disposition http://purl.obolibrary.org/obo/BFO_0000017 realizable entity http://purl.obolibrary.org/obo/BFO_0000019 quality http://purl.obolibrary.org/obo/BFO_0000020 specifically dependent continuant http://purl.obolibrary.org/obo/BFO_0000006 spatial region http://purl.obolibrary.org/obo/BFO_0000141 immaterial entity http://purl.obolibrary.org/obo/BFO_0000002 continuant An entity that exists in full at any time in which it exists at all, persists through time while maintaining its identity and has no temporal parts. http://purl.obolibrary.org/obo/BFO_0000003 occurrent An entity that has temporal parts and that happens, unfolds or develops through time. http://purl.obolibrary.org/obo/IAO_0000078 curation status specification The curation status of the term. The allowed values come from an enumerated list of predefined terms. See the specification of these instances for more detailed definitions of each enumerated value. http://purl.obolibrary.org/obo/OBI_0000967 container A device that can be used to restrict the location of material entities over time http://purl.obolibrary.org/obo/RO_0002310 obsolete exposure event or process OBSOLETE A process occurring within or in the vicinity of an organism that exerts some causal influence on the organism via the interaction between an exposure stimulus and an exposure receptor. The exposure stimulus may be a process, material entity or condition (for example, lack of nutrients). The exposure receptor can be an organism, organism population or a part of an organism. http://purl.obolibrary.org/obo/RO_0002532 sequentially ordered entity Any entity that is ordered in discrete units along a linear axis. http://purl.obolibrary.org/obo/GO_0005634 nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. http://purl.obolibrary.org/obo/RO_0002234 has output http://purl.obolibrary.org/obo/RO_0000057 has participant produces p has output c iff c is a participant in p, c is present at the end of p, and c is not present in the same state at the beginning of p. http://purl.obolibrary.org/obo/RO_0000052 characteristic of http://purl.obolibrary.org/obo/RO_0002314 characteristic of part of inheres_in a relation between a specifically dependent continuant (the characteristic) and any other entity (the bearer), in which the characteristic depends on the bearer for its existence. http://purl.obolibrary.org/obo/RO_0000079 function of http://purl.obolibrary.org/obo/RO_0000052 characteristic of is function of a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0000080 quality of http://purl.obolibrary.org/obo/RO_0000052 characteristic of quality_of a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0000085 has function http://purl.obolibrary.org/obo/RO_0000053 has characteristic has_function a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0000086 has quality http://purl.obolibrary.org/obo/RO_0000053 has characteristic has_quality a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0002000 2D boundary of http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to surface of a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity http://purl.obolibrary.org/obo/RO_0002002 has 2D boundary http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to has_2D_boundary a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity http://purl.obolibrary.org/obo/RO_0002350 member of http://purl.obolibrary.org/obo/BFO_0000050 part of member part of is member of is a mereological relation between a item and a collection. http://purl.obolibrary.org/obo/BFO_0000051 has part http://purl.obolibrary.org/obo/RO_0002131 overlaps has_part a core relation that holds between a whole and its part http://purl.obolibrary.org/obo/RO_0000087 has role http://purl.obolibrary.org/obo/RO_0000053 has characteristic has_role a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0002327 enables http://purl.obolibrary.org/obo/RO_0002215 capable of is executing c enables p iff c is capable of p and c acts to execute p. http://purl.obolibrary.org/obo/RO_0002409 indirectly negatively regulates http://purl.obolibrary.org/obo/RO_0012012 indirectly regulates indirectly inhibits p indirectly negatively regulates q iff p is indirectly causally upstream of q and p negatively regulates q. http://purl.obolibrary.org/obo/RO_0002436 molecularly interacts with http://purl.obolibrary.org/obo/RO_0002434 interacts with molecularly binds with An interaction relationship in which the two partners are molecular entities that directly physically interact with each other for example via a stable binding interaction or a brief interaction during which one modifies the other. http://purl.obolibrary.org/obo/RO_0002449 directly negatively regulates activity of http://purl.obolibrary.org/obo/RO_0002448 directly regulates activity of directly inhibits The entity A, immediately upstream of the entity B, has an activity that negatively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A negatively regulates the kinase activity of B. http://purl.obolibrary.org/obo/RO_0002378 anabranch of http://purl.obolibrary.org/obo/RO_0002377 distributary of anastomoses with x anabranch_of y if x is a distributary of y (i.e. it channels a from a larger flow from y) and x ultimately channels the flow back into y. http://purl.obolibrary.org/obo/RO_0002524 has subsequence http://purl.obolibrary.org/obo/RO_0002526 overlaps sequence of contains x has subsequence y iff all of the sequence parts of y are sequence parts of x http://purl.obolibrary.org/obo/RO_0002525 is subsequence of http://purl.obolibrary.org/obo/RO_0002526 overlaps sequence of contained by inverse of has subsequence http://purl.obolibrary.org/obo/RO_0003305 contributes to severity of condition http://purl.obolibrary.org/obo/RO_0003304 contributes to condition contributes to expressivity of condition A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity influences the severity with which a condition manifests in an individual. http://purl.obolibrary.org/obo/RO_0003306 contributes to frequency of condition http://purl.obolibrary.org/obo/RO_0003304 contributes to condition contributes to penetrance of condition A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity influences the frequency of the condition in a population. http://purl.obolibrary.org/obo/RO_0003307 ameliorates condition http://purl.obolibrary.org/obo/RO_0003305 contributes to severity of condition is preventative for condition A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the presence of the entity reduces or eliminates some or all aspects of the condition. http://purl.obolibrary.org/obo/RO_0002150 continuous with http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to connected to X continuous_with Y if and only if X and Y share a fiat boundary. http://purl.obolibrary.org/obo/RO_0011013 indirectly positively regulates activity of http://purl.obolibrary.org/obo/RO_0011004 indirectly regulates activity of indirectly activates The entity A is not immediately upstream of the entity B and has an activity that up-regulates an activity performed by B. http://purl.obolibrary.org/obo/RO_0011016 indirectly negatively regulates activity of http://purl.obolibrary.org/obo/RO_0011004 indirectly regulates activity of indirectly inhibits The entity A is not immediately upstream of the entity B and has an activity that down-regulates an activity performed by B. http://purl.obolibrary.org/obo/BFO_0000062 preceded by http://purl.obolibrary.org/obo/RO_0002086 ends after preceded_by x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. http://purl.obolibrary.org/obo/RO_0002156 derived by descent from http://purl.obolibrary.org/obo/RO_0002320 evolutionarily related to evolutionarily_descended_from d derived_by_descent_from a if d is specified by some genetic program that is sequence-inherited-from a genetic program that specifies a. http://purl.obolibrary.org/obo/RO_0000081 role of http://purl.obolibrary.org/obo/RO_0000052 characteristic of role_of a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0017003 positively correlated with http://purl.obolibrary.org/obo/RO_0002610 correlated with directly correlated with A relation between entities in which one increases or decreases as the other does the same. http://purl.obolibrary.org/obo/RO_0017004 negatively correlated with http://purl.obolibrary.org/obo/RO_0002610 correlated with inversely correlated with A relation between entities in which one increases as the other decreases. http://purl.obolibrary.org/obo/BFO_0000050 part of http://purl.obolibrary.org/obo/RO_0002131 overlaps part_of a core relation that holds between a part and its whole http://purl.obolibrary.org/obo/RO_0002233 has input http://purl.obolibrary.org/obo/RO_0000057 has participant consumes p has input c iff: p is a process, c is a material entity, c is a participant in p, c is present at the start of p, and the state of c is modified during p. http://purl.obolibrary.org/obo/RO_0002314 characteristic of part of http://purl.obolibrary.org/obo/RO_0002502 depends on inheres in part of q characteristic of part of w if and only if there exists some p such that q inheres in p and p part of w. http://purl.obolibrary.org/obo/RO_0002215 capable of http://purl.obolibrary.org/obo/RO_0002216 capable of part of has function realized in A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. http://purl.obolibrary.org/obo/RO_0002331 involved in http://purl.obolibrary.org/obo/RO_0002431 involved in or involved in regulation of enables part of c involved_in p if and only if c enables some process p', and p' is part of p http://purl.obolibrary.org/obo/RO_0002376 tributary of http://purl.obolibrary.org/obo/RO_0002375 in branching relationship with tributary channel of x tributary_of y if and only if x a channel for the flow of a substance into y, where y is larger than x. If x and y are hydrographic features, then y is the main stem of a river, or a lake or bay, but not the sea or ocean. If x and y are anatomical, then y is a vein. http://purl.obolibrary.org/obo/RO_0002377 distributary of http://purl.obolibrary.org/obo/RO_0002375 in branching relationship with distributary channel of x distributary_of y if and only if x is capable of channeling the flow of a substance to y, where y channels less of the substance than x http://purl.obolibrary.org/obo/RO_0002431 involved in or involved in regulation of http://purl.obolibrary.org/obo/RO_0002500 causal agent in process involved in or reguates c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p http://purl.obolibrary.org/obo/RO_0002437 biotically interacts with http://purl.obolibrary.org/obo/RO_0002321 ecologically related to interacts with on organism level An interaction relationship in which at least one of the partners is an organism and the other is either an organism or an abiotic entity with which the organism interacts. http://purl.obolibrary.org/obo/RO_0002551 has skeleton http://purl.obolibrary.org/obo/BFO_0000051 has part has supporting framework A relation between a segment or subdivision of an organism and the maximal subdivision of material entities that provides structural support for that segment or subdivision. http://purl.obolibrary.org/obo/RO_0002101 fasciculates with http://purl.obolibrary.org/obo/RO_0002131 overlaps fasciculates with relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through. http://purl.obolibrary.org/obo/RO_0002110 has postsynaptic terminal in http://purl.obolibrary.org/obo/RO_0002130 has synaptic terminal in synapsed in Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. http://purl.obolibrary.org/obo/RO_0002113 has presynaptic terminal in http://purl.obolibrary.org/obo/RO_0002130 has synaptic terminal in synapses in Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. http://purl.obolibrary.org/obo/RO_0002130 has synaptic terminal in http://purl.obolibrary.org/obo/RO_0002131 overlaps has synapse in A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input. http://purl.obolibrary.org/obo/RO_0002151 partially overlaps http://purl.obolibrary.org/obo/RO_0002131 overlaps proper overlaps x partially overlaps y iff there exists some z such that z is part of x and z is part of y, and it is also the case that neither x is part of y or y is part of x http://purl.obolibrary.org/obo/RO_0002216 capable of part of http://purl.obolibrary.org/obo/RO_0002500 causal agent in process has function in c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p. http://purl.obolibrary.org/obo/RO_0002329 part of structure that is capable of http://purl.obolibrary.org/obo/RO_0002328 functionally related to 0 this relation holds between c and p when c is part of some c', and c' is capable of p. http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within http://purl.obolibrary.org/obo/RO_0002501 causal relation between processes influences (processual) p is 'causally upstream or within' q iff p is causally related to q, and the end of p precedes, or is coincident with, the end of q. http://purl.obolibrary.org/obo/RO_0002132 has fasciculating neuron projection http://purl.obolibrary.org/obo/RO_0002131 overlaps has fasciculating component The relation between a neuron projection bundle and a neuron projection that is fasciculated with it. http://purl.obolibrary.org/obo/RO_0002210 directly develops into http://purl.obolibrary.org/obo/RO_0002203 develops into developmental precursor of inverse of directly develops from http://purl.obolibrary.org/obo/RO_0002224 starts with http://purl.obolibrary.org/obo/RO_0002222 temporally related to started by x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. http://purl.obolibrary.org/obo/RO_0002230 ends with http://purl.obolibrary.org/obo/RO_0002222 temporally related to finished by x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. http://purl.obolibrary.org/obo/RO_0002231 has start location http://purl.obolibrary.org/obo/RO_0002479 has part that occurs in starts with process that occurs in x 'has starts location' y if and only if there exists some process z such that x 'starts with' z and z 'occurs in' y http://purl.obolibrary.org/obo/RO_0002232 has end location http://purl.obolibrary.org/obo/RO_0002479 has part that occurs in ends with process that occurs in x 'has end location' y if and only if there exists some process z such that x 'ends with' z and z 'occurs in' y http://purl.obolibrary.org/obo/RO_0002256 developmentally induced by http://purl.obolibrary.org/obo/RO_0002258 developmentally preceded by induced by t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor material anatomical entity type T to T', where T' develops_from T http://purl.obolibrary.org/obo/RO_0002285 developmentally replaces http://purl.obolibrary.org/obo/RO_0002258 developmentally preceded by replaces x developmentally replaces y if and only if there is some developmental process that causes x to move or to cease to exist, and for the site that was occupied by x to become occupied by y, where y either comes into existence in this site or moves to this site from somewhere else http://purl.obolibrary.org/obo/RO_0002303 has habitat http://purl.obolibrary.org/obo/RO_0002321 ecologically related to adapted for living in x 'has habitat' y if and only if: x is an organism, y is a habitat, and y can sustain and allow the growth of a population of xs. http://purl.obolibrary.org/obo/RO_0002313 transports or maintains localization of http://purl.obolibrary.org/obo/RO_0002337 related via localization to regulates localization of Holds between p and c when p is a localization process (localization covers maintenance of localization as well as its establishment) and the outcome of this process is to regulate the localization of c. http://purl.obolibrary.org/obo/RO_0002400 has direct input http://purl.obolibrary.org/obo/RO_0002233 has input directly consumes p has direct input c iff c is a participant in p, c is present at the start of p, and the state of c is modified during p. http://purl.obolibrary.org/obo/RO_0002407 indirectly positively regulates http://purl.obolibrary.org/obo/RO_0012012 indirectly regulates indirectly activates p indirectly positively regulates q iff p is indirectly causally upstream of q and p positively regulates q. http://purl.obolibrary.org/obo/RO_0002413 provides input for http://purl.obolibrary.org/obo/RO_0002414 transitively provides input for directly provides input for p provides input for q iff p is immediately causally upstream of q, and there exists some c such that p has_output c and q has_input c. http://purl.obolibrary.org/obo/RO_0002432 is active in http://purl.obolibrary.org/obo/RO_0002328 functionally related to executes activity in c executes activity in d if and only if c enables p and p occurs_in d. Assuming no action at a distance by gene products, if a gene product enables (is capable of) a process that occurs in some structure, it must have at least some part in that structure. http://purl.obolibrary.org/obo/RO_0002439 preys on http://purl.obolibrary.org/obo/RO_0002438 trophically interacts with preys upon An interaction relationship involving a predation process, where the subject kills the target in order to eat it or to feed to siblings, offspring or group members http://purl.obolibrary.org/obo/RO_0002444 parasite of http://purl.obolibrary.org/obo/RO_0002454 has host parasitizes A parasite-host relationship where an organism benefits at the expense of another. http://purl.obolibrary.org/obo/RO_0002445 parasitized by http://purl.obolibrary.org/obo/RO_0002453 host of parasitised by Inverse of parasite of http://purl.obolibrary.org/obo/RO_0002450 directly positively regulates activity of http://purl.obolibrary.org/obo/RO_0002448 directly regulates activity of directly activates The entity A, immediately upstream of the entity B, has an activity that positively regulates an activity performed by B. For example, A and B may be gene products and binding of B by A positively regulates the kinase activity of B. http://purl.obolibrary.org/obo/RO_0002458 preyed upon by http://purl.obolibrary.org/obo/RO_0002438 trophically interacts with is target of predation interaction with inverse of preys on http://purl.obolibrary.org/obo/RO_0002470 eats http://purl.obolibrary.org/obo/RO_0002437 biotically interacts with is subject of eating interaction with A biotic interaction where one organism consumes a material entity through a type of mouth or other oral opening. http://purl.obolibrary.org/obo/RO_0002471 is eaten by http://purl.obolibrary.org/obo/RO_0002437 biotically interacts with is target of eating interaction with Inverse of eats http://purl.obolibrary.org/obo/RO_0002505 has intermediate http://purl.obolibrary.org/obo/RO_0000057 has participant has intermediate product p has intermediate c if and only if p has parts p1, p2 and p1 has output c, and p2 has input c http://purl.obolibrary.org/obo/RO_0002516 has start sequence http://purl.obolibrary.org/obo/RO_0002524 has subsequence started by x has start sequence y if the start of x is identical to the start of y, and x has y as a subsequence http://purl.obolibrary.org/obo/RO_0002517 is start sequence of http://purl.obolibrary.org/obo/RO_0002525 is subsequence of starts inverse of has start sequence http://purl.obolibrary.org/obo/RO_0002518 has end sequence http://purl.obolibrary.org/obo/RO_0002524 has subsequence ended by x has end sequence y if the end of x is identical to the end of y, and x has y as a subsequence http://purl.obolibrary.org/obo/RO_0002519 is end sequence of http://purl.obolibrary.org/obo/RO_0002525 is subsequence of ends inverse of has end sequence http://purl.obolibrary.org/obo/RO_0002527 does not overlap sequence of http://purl.obolibrary.org/obo/RO_0002514 sequentially related to disconnected from x does not overlap the sequence of y if and only if there is no z such that x has a subsequence z and z is a subsequence of y. http://purl.obolibrary.org/obo/RO_0002599 capable of inhibiting or preventing pathological process http://purl.obolibrary.org/obo/RO_0002597 capable of negatively regulating treats Holds between a material entity c and a pathological process p if and only if c is capable of some activity a, where a inhibits p. http://purl.obolibrary.org/obo/RO_0002600 capable of upregulating or causing pathological process http://purl.obolibrary.org/obo/RO_0002598 capable of positively regulating causes disease Holds between a material entity c and a pathological process p if and only if c is capable of some activity a, where a negatively regulates p. http://purl.obolibrary.org/obo/RO_0002606 is substance that treats http://purl.obolibrary.org/obo/RO_0002599 capable of inhibiting or preventing pathological process treats c is a substance that treats d if c is a material entity (such as a small molecule or compound) and d is a pathological process, phenotype or disease, and c is capable of some activity that negative regulates or decreases the magnitude of d. http://purl.obolibrary.org/obo/RO_0004027 disease has inflammation site http://purl.obolibrary.org/obo/RO_0004026 disease has location A relationship between a disease and an anatomical entity where the disease is triggered by an inflammatory response to stimuli occurring in the anatomical entity http://purl.obolibrary.org/obo/RO_0004028 realized in response to stimulus http://purl.obolibrary.org/obo/RO_0002410 causally related to A relationship between a realizable entity R (e.g. function or disposition) and a material entity M where R is realized in response to a process that has an input stimulus of M. http://purl.obolibrary.org/obo/RO_0004029 disease has feature http://purl.obolibrary.org/obo/RO_0040035 disease relationship A relationship between a disease and some feature of that disease, where the feature is either a phenotype or an isolated disease. http://purl.obolibrary.org/obo/RO_0004030 disease arises from alteration in structure http://purl.obolibrary.org/obo/RO_0004019 disease has basis in A relationship between a disease and an anatomical structure where the material basis of the disease is some pathological change in the structure. Anatomical structure includes cellular and sub-cellular entities, such as chromosome and organelles. http://purl.obolibrary.org/obo/RO_0004009 has primary input http://purl.obolibrary.org/obo/RO_0002233 has input p has primary input c if (a) p has input c and (b) the goal of process is to modify, consume, or transform c. http://purl.obolibrary.org/obo/RO_HOM0000001 in homology relationship with http://purl.obolibrary.org/obo/RO_0002158 shares ancestor with Similarity that results from common evolutionary origin. http://purl.obolibrary.org/obo/RO_HOM0000016 in non functional homology relationship with http://purl.obolibrary.org/obo/RO_HOM0000006 in structural homology relationship with Structural homology that involves a pseudogenic feature and its functional ancestor. http://purl.obolibrary.org/obo/RO_0002025 has effector activity http://purl.obolibrary.org/obo/RO_0002017 has component activity A 'has effector activity' B if A and B are GO molecular functions (GO_0003674), A 'has component activity' B and B is the effector (output function) of B. Each compound function has only one effector activity. http://purl.obolibrary.org/obo/RO_0040036 results in changes to anatomical or cellular structure http://purl.obolibrary.org/obo/RO_0000057 has participant p has anatomical participant c iff p has participant c, and c is an anatomical entity http://purl.obolibrary.org/obo/ENVO_02000200 has increased levels of http://purl.obolibrary.org/obo/RO_0002180 has component A has part relationship between a whole and a part, where the number of parts present in the whole is higher than in comparable entities. http://purl.obolibrary.org/obo/RO_0002100 has soma location http://purl.obolibrary.org/obo/RO_0002131 overlaps Relation between a neuron and a material anatomical entity that its soma is part of. http://purl.obolibrary.org/obo/RO_0002160 only in taxon http://purl.obolibrary.org/obo/RO_0002162 in taxon x only in taxon y if and only if x is in taxon y, and there is no other organism z such that y!=z a and x is in taxon z. http://purl.obolibrary.org/obo/RO_0002258 developmentally preceded by http://purl.obolibrary.org/obo/RO_0002324 developmentally related to Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p http://purl.obolibrary.org/obo/RO_0002162 in taxon http://purl.obolibrary.org/obo/RO_0002320 evolutionarily related to x is in taxon y if an only if y is an organism, and the relationship between x and y is one of: part of (reflexive), developmentally preceded by, derives from, secreted by, expressed. http://purl.obolibrary.org/obo/RO_0002286 developmentally succeeded by http://purl.obolibrary.org/obo/RO_0002384 has developmental potential involving Inverse of developmentally preceded by http://purl.obolibrary.org/obo/RO_0002371 attached to http://purl.obolibrary.org/obo/RO_0002177 attached to part of a is attached to b if and only if a and b are discrete objects or object parts, and there are physical connections between a and b such that a force pulling a will move b, or a force pulling b will move a http://purl.obolibrary.org/obo/RO_0002384 has developmental potential involving http://purl.obolibrary.org/obo/RO_0002324 developmentally related to x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction). http://purl.obolibrary.org/obo/RO_0002388 has potential to directly develop into http://purl.obolibrary.org/obo/RO_0002387 has potential to develop into x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y http://purl.obolibrary.org/obo/RO_0002178 supplies http://purl.obolibrary.org/obo/RO_0002170 connected to Relation between an arterial structure and another structure, where the arterial structure acts as a conduit channeling fluid, substance or energy. http://purl.obolibrary.org/obo/RO_0002372 has muscle origin http://purl.obolibrary.org/obo/RO_0002567 biomechanically related to m has_muscle_origin s iff m is attached_to s, and it is the case that when m contracts, s does not move. The site of the origin tends to be more proximal and have greater mass than what the other end attaches to. http://purl.obolibrary.org/obo/RO_0002374 derived from ancestral fusion of http://purl.obolibrary.org/obo/RO_0002156 derived by descent from x has_fused_element y iff: there exists some z : x has_part z, z homologous_to y, and y is a distinct element, the boundary between x and z is largely fiat http://purl.obolibrary.org/obo/RO_0002380 branching part of http://purl.obolibrary.org/obo/RO_0002375 in branching relationship with x is a branching part of y if and only if x is part of y and x is connected directly or indirectly to the main stem of y http://purl.obolibrary.org/obo/RO_0002476 child nucleus of http://purl.obolibrary.org/obo/RO_0002258 developmentally preceded by c is a child nucleus of d if and only if c and d are both nuclei and parts of cells c' and d', where c' is derived from d' by mitosis and the genetic material in c is a copy of the generic material in d http://purl.obolibrary.org/obo/RO_0002477 child nucleus of in hermaphrodite http://purl.obolibrary.org/obo/RO_0002476 child nucleus of A child nucleus relationship in which the cells are part of a hermaphroditic organism http://purl.obolibrary.org/obo/RO_0002478 child nucleus of in male http://purl.obolibrary.org/obo/RO_0002476 child nucleus of A child nucleus relationship in which the cells are part of a male organism http://purl.obolibrary.org/obo/RO_0002568 has muscle antagonist http://purl.obolibrary.org/obo/RO_0002567 biomechanically related to m1 has_muscle_antagonist m2 iff m1 has_muscle_insertion s, m2 has_muscle_insection s, m1 acts in opposition to m2, and m2 is responsible for returning the structure to its initial position. http://purl.obolibrary.org/obo/RO_0002569 has branching part http://purl.obolibrary.org/obo/RO_0002375 in branching relationship with inverse of branching part of http://purl.obolibrary.org/obo/RO_0002571 lumen of http://purl.obolibrary.org/obo/BFO_0000050 part of x lumen_of y iff x is the space or substance that is part of y and does not cross any of the inner membranes or boundaries of y that is maximal with respect to the volume of the convex hull. http://purl.obolibrary.org/obo/RO_0004020 disease has basis in dysfunction of http://purl.obolibrary.org/obo/RO_0004019 disease has basis in A relation that holds between the disease and a material entity where the physical basis of the disease is a disorder of that material entity that affects its function. http://purl.obolibrary.org/obo/RO_0004021 disease has basis in disruption of http://purl.obolibrary.org/obo/RO_0004019 disease has basis in A relation that holds between the disease and a process where the physical basis of the disease disrupts execution of a key biological process. http://purl.obolibrary.org/obo/RO_0004022 disease has basis in feature http://purl.obolibrary.org/obo/RO_0004019 disease has basis in A relation that holds between the disease and a feature (a phenotype or other disease) where the physical basis of the disease is the feature. http://purl.obolibrary.org/obo/RO_0004024 disease causes disruption of http://purl.obolibrary.org/obo/RO_0004023 causal relationship with disease as subject A relationship between a disease and a process where the disease process disrupts the execution of the process. http://purl.obolibrary.org/obo/RO_0004007 has primary input or output http://purl.obolibrary.org/obo/RO_0000057 has participant p 'has primary input ot output' c iff either (a) p 'has primary input' c or (b) p 'has primary output' c. http://purl.obolibrary.org/obo/RO_0004008 has primary output http://purl.obolibrary.org/obo/RO_0004007 has primary input or output p has primary output c if (a) p has output c and (b) the goal of process is to modify, produce, or transform c. http://purl.obolibrary.org/obo/BFO_0000063 precedes http://purl.obolibrary.org/obo/RO_0002222 temporally related to x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point. http://purl.obolibrary.org/obo/RO_0002219 surrounded by http://purl.obolibrary.org/obo/RO_0002220 adjacent to x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x http://purl.obolibrary.org/obo/RO_0002220 adjacent to http://purl.obolibrary.org/obo/RO_0002163 spatially disjoint from x adjacent to y if and only if x and y share a boundary. http://purl.obolibrary.org/obo/RO_0002223 starts http://purl.obolibrary.org/obo/BFO_0000050 part of inverse of starts with http://purl.obolibrary.org/obo/RO_0002351 has member http://purl.obolibrary.org/obo/BFO_0000051 has part has member is a mereological relation between a collection and an item. http://purl.obolibrary.org/obo/RO_0002018 has component process http://purl.obolibrary.org/obo/RO_0002180 has component w 'has process component' p if p and w are processes, w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type. http://purl.obolibrary.org/obo/RO_0009005 has primary substance added http://purl.obolibrary.org/obo/RO_0009001 has substance added 'has primary substance added' indicates that an entity has had the given substance added to it in a proportion greater than any other added substance. http://purl.obolibrary.org/obo/RO_0007001 has disease driver http://purl.obolibrary.org/obo/RO_0007000 has driver A relation between an entity and a disease of a host, in which the entity is not part of the host itself, and the condition results in pathological processes. http://purl.obolibrary.org/obo/RO_0019000 regulates characteristic http://purl.obolibrary.org/obo/RO_0002410 causally related to A relationship that holds between a process and a characteristic in which process (P) regulates characteristic (C) iff: P results in the existence of C OR affects the intensity or magnitude of C. http://purl.obolibrary.org/obo/RO_0019001 positively regulates characteristic http://purl.obolibrary.org/obo/RO_0019000 regulates characteristic A relationship that holds between a process and a characteristic in which process (P) positively regulates characteristic (C) iff: P results in an increase in the intensity or magnitude of C. http://purl.obolibrary.org/obo/RO_0019002 negatively regulates characteristic http://purl.obolibrary.org/obo/RO_0019000 regulates characteristic A relationship that holds between a process and a characteristic in which process (P) negatively regulates characteristic (C) iff: P results in a decrease in the intensity or magnitude of C. http://purl.obolibrary.org/obo/RO_0019501 confers susceptibility to condition http://purl.obolibrary.org/obo/RO_0003304 contributes to condition Relates a gene to condition, such that a variation in this gene predisposes to the development of a condition. http://purl.obolibrary.org/obo/RO_0001020 is allergic trigger for http://purl.obolibrary.org/obo/RO_0003302 causes or contributes to condition A relation between a material entity and a condition (a phenotype or disease) of a host, in which the material entity is not part of the host, and is considered harmless to non-allergic hosts, and the condition results in pathological processes that include an abnormally strong immune response against the material entity. http://purl.obolibrary.org/obo/RO_0001021 is autoimmune trigger for http://purl.obolibrary.org/obo/RO_0003302 causes or contributes to condition A relation between a material entity and a condition (a phenotype or disease) of a host, in which the material entity is part of the host itself, and the condition results in pathological processes that include an abnormally strong immune response against the material entity. http://purl.obolibrary.org/obo/RO_0002200 has phenotype http://purl.obolibrary.org/obo/RO_0016001 has phenotype or disease A relationship that holds between a biological entity and a phenotype. Here a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). The subject of this relationship can be an organism (where the organism has the phenotype, i.e. the qualities inhere in parts of this organism), a genomic entity such as a gene or genotype (if modifications of the gene or the genotype causes the phenotype), or a condition such as a disease (such that if the condition inheres in an organism, then the organism has the phenotype). http://purl.obolibrary.org/obo/RO_0002202 develops from http://purl.obolibrary.org/obo/RO_0002254 has developmental contribution from x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y http://purl.obolibrary.org/obo/RO_0002451 transmitted by http://purl.obolibrary.org/obo/RO_0002321 ecologically related to A relationship that holds between a disease and organism http://purl.obolibrary.org/obo/RO_0003304 contributes to condition http://purl.obolibrary.org/obo/RO_0003302 causes or contributes to condition A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some contributing role that influences the condition. http://purl.obolibrary.org/obo/RO_0002309 has exposure stimulus http://purl.obolibrary.org/obo/RO_0002244 related via exposure to A relationship between an exposure event or process and any agent, stimulus, activity, or event that causally effects an organism and interacts with an exposure receptor during an exposure event. http://purl.obolibrary.org/obo/RO_0016002 has disease http://purl.obolibrary.org/obo/RO_0016001 has phenotype or disease A relationship that holds between an organism and a disease. Here a disease is construed broadly as a disposition to undergo pathological processes that exists in an organism because of one or more disorders in that organism. http://purl.obolibrary.org/obo/RO_0020332 assesses toxicity of http://purl.obolibrary.org/obo/RO_0020334 indicates clinical effect of A relationship between a biomarker 'b' and an exposure agent 'e', where 'b' is used to indicate the likelihood, presence, or extent of toxicity as an adverse effect of exposure to 'e'. http://purl.obolibrary.org/obo/RO_0002176 connects http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to c connects a if and only if there exist some b such that a and b are similar parts of the same system, and c connects b, specifically, c connects a with b. When one structure connects two others it unites some aspect of the function or role they play within the system. http://purl.obolibrary.org/obo/RO_0002491 existence starts and ends during http://purl.obolibrary.org/obo/RO_0002492 existence ends during x exists during y if and only if: 1) the time point at which x begins to exist is after or equal to the time point at which y begins and 2) the time point at which x ceases to exist is before or equal to the point at which y ends. Formally: x existence starts and ends during y iff α(x) >= α(y) & α(x) <= ω(y) & ω(x) <= ω(y) & ω(x) >= α(y) http://purl.obolibrary.org/obo/RO_0002333 enabled by http://purl.obolibrary.org/obo/RO_0002328 functionally related to inverse of enables http://purl.obolibrary.org/obo/RO_0002404 causally downstream of http://purl.obolibrary.org/obo/RO_0002427 causally downstream of or within inverse of upstream of http://purl.obolibrary.org/obo/RO_0002412 immediately causally upstream of http://purl.obolibrary.org/obo/RO_0002411 causally upstream of p is immediately causally upstream of q iff p is causally upstream of q, and the end of p is coincident with the beginning of q. http://purl.obolibrary.org/obo/RO_0002448 directly regulates activity of http://purl.obolibrary.org/obo/RO_0011002 regulates activity of The entity A, immediately upstream of the entity B, has an activity that regulates an activity performed by B. For example, A and B may be gene products and binding of B by A regulates the kinase activity of B. A and B can be physically interacting but not necessarily. Immediately upstream means there are no intermediate entity between A and B. http://purl.obolibrary.org/obo/RO_0002566 causally influences http://purl.obolibrary.org/obo/RO_0002506 causal relation between entities The entity or characteristic A is causally upstream of the entity or characteristic B, A having an effect on B. An entity corresponds to any biological type of entity as long as a mass is measurable. A characteristic corresponds to a particular specificity of an entity (e.g., phenotype, shape, size). http://purl.obolibrary.org/obo/RO_0003302 causes or contributes to condition http://purl.obolibrary.org/obo/RO_0002410 causally related to A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal or contributing role that influences the condition. http://purl.obolibrary.org/obo/RO_0003303 causes condition http://purl.obolibrary.org/obo/RO_0003302 causes or contributes to condition A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal role for the condition. http://purl.obolibrary.org/obo/RO_0003308 correlated with condition http://purl.obolibrary.org/obo/RO_0002610 correlated with A relationship between an entity and a condition (phenotype or disease) with which it exhibits a statistical dependence relationship. http://purl.obolibrary.org/obo/RO_0002490 existence overlaps http://purl.obolibrary.org/obo/RO_0002487 relation between physical entity and a process or stage x existence overlaps y if and only if either (a) the start of x is part of y or (b) the end of x is part of y. Formally: x existence starts and ends during y iff (α(x) >= α(y) & α(x) <= ω(y)) OR (ω(x) <= ω(y) & ω(x) >= α(y)) http://purl.obolibrary.org/obo/RO_0002208 parasitoid of http://purl.obolibrary.org/obo/RO_0002444 parasite of A parasite that kills or sterilizes its host http://purl.obolibrary.org/obo/RO_0002209 has parasitoid http://purl.obolibrary.org/obo/RO_0002445 parasitized by inverse of parasitoid of http://purl.obolibrary.org/obo/RO_0002235 stem parasite of http://purl.obolibrary.org/obo/RO_0002444 parasite of A parasite-of relationship in which the host is a plant and the parasite that attaches to the host stem (PO:0009047) http://purl.obolibrary.org/obo/RO_0002236 root parasite of http://purl.obolibrary.org/obo/RO_0002444 parasite of A parasite-of relationship in which the host is a plant and the parasite that attaches to the host root (PO:0009005) http://purl.obolibrary.org/obo/RO_0002237 hemiparasite of http://purl.obolibrary.org/obo/RO_0002444 parasite of A sub-relation of parasite-of in which the parasite is a plant, and the parasite is parasitic under natural conditions and is also photosynthetic to some degree. Hemiparasites may just obtain water and mineral nutrients from the host plant. Many obtain at least part of their organic nutrients from the host as well. http://purl.obolibrary.org/obo/RO_0001022 has allergic trigger http://purl.obolibrary.org/obo/RO_0003302 causes or contributes to condition A relation between a condition (a phenotype or disease) of a host and a material entity, in which the material entity is not part of the host, and is considered harmless to non-allergic hosts, and the condition results in pathological processes that include an abnormally strong immune response against the material entity. http://purl.obolibrary.org/obo/RO_0001023 has autoimmune trigger http://purl.obolibrary.org/obo/RO_0003302 causes or contributes to condition A relation between a condition (a phenotype or disease) of a host and a material entity, in which the material entity is part of the host itself, and the condition results in pathological processes that include an abnormally strong immune response against the material entity. http://purl.obolibrary.org/obo/RO_0002012 occurrent part of http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within A part of relation that applies only between occurrents. http://purl.obolibrary.org/obo/RO_0002240 has exposure receptor http://purl.obolibrary.org/obo/RO_0002244 related via exposure to A broad relationship between an exposure event or process and any entity (e.g., an organism, organism population, or an organism part) that interacts with an exposure stimulus during the exposure event. http://purl.obolibrary.org/obo/RO_0002241 has exposure stressor http://purl.obolibrary.org/obo/RO_0002309 has exposure stimulus A broad relationship between an exposure event or process and any agent, stimulus, activity, or event that causes stress or tension on an organism and interacts with an exposure receptor during an exposure event. http://purl.obolibrary.org/obo/RO_0002242 has exposure route http://purl.obolibrary.org/obo/RO_0002244 related via exposure to A broad relationship between an exposure event or process and a process by which the exposure stressor comes into contact with the exposure receptor http://purl.obolibrary.org/obo/RO_0002243 has exposure transport path http://purl.obolibrary.org/obo/RO_0002244 related via exposure to A broad relationship between an exposure event or process and the course takes from the source to the target. http://purl.obolibrary.org/obo/RO_0002244 related via exposure to http://purl.obolibrary.org/obo/RO_0002410 causally related to Any relationship between an exposure event or process and any other entity. http://purl.obolibrary.org/obo/RO_0002245 over-expressed in http://purl.obolibrary.org/obo/RO_0002206 expressed in g is over-expressed in t iff g is expressed in t, and the expression level of g is increased relative to some background. http://purl.obolibrary.org/obo/RO_0002246 under-expressed in http://purl.obolibrary.org/obo/RO_0002206 expressed in g is under-expressed in t iff g is expressed in t, and the expression level of g is decreased relative to some background. http://purl.obolibrary.org/obo/RO_0002248 has active ingredient http://purl.obolibrary.org/obo/BFO_0000051 has part A relationship that holds between a substance and a chemical entity, if the chemical entity is part of the substance, and the chemical entity forms the biologically active component of the substance. http://purl.obolibrary.org/obo/RO_0002249 active ingredient in http://purl.obolibrary.org/obo/BFO_0000050 part of inverse of has active ingredient http://purl.obolibrary.org/obo/RO_0002252 connecting branch of http://purl.obolibrary.org/obo/RO_0002375 in branching relationship with b connecting-branch-of s iff b is connected to s, and there exists some tree-like structure t such that the mereological sum of b plus s is either the same as t or a branching-part-of t. http://purl.obolibrary.org/obo/RO_0002253 has connecting branch http://purl.obolibrary.org/obo/RO_0002375 in branching relationship with inverse of connecting branch of http://purl.obolibrary.org/obo/RO_0002260 has biological role http://purl.obolibrary.org/obo/RO_0000087 has role c has-biological-role r iff c has-role r and r is a biological role (CHEBI:24432) http://purl.obolibrary.org/obo/RO_0002261 has application role http://purl.obolibrary.org/obo/RO_0000087 has role c has-application-role r iff c has-role r and r is an application role (CHEBI:33232) http://purl.obolibrary.org/obo/RO_0002262 has chemical role http://purl.obolibrary.org/obo/RO_0000087 has role c has-chemical-role r iff c has-role r and r is a chemical role (CHEBI:51086) http://purl.obolibrary.org/obo/RO_0002263 acts upstream of http://purl.obolibrary.org/obo/RO_0002264 acts upstream of or within c acts upstream of p if and only if c enables some f that is involved in p' and p' occurs chronologically before p, is not part of p, and affects the execution of p. c is a material entity and f, p, p' are processes. http://purl.obolibrary.org/obo/RO_0002302 is treated by substance http://purl.obolibrary.org/obo/RO_0002410 causally related to Inverse of 'is substance that treats' http://purl.obolibrary.org/obo/RO_0002304 causally upstream of, positive effect http://purl.obolibrary.org/obo/RO_0004047 causally upstream of or within, positive effect p is causally upstream of, positive effect q iff p is casually upstream of q, and the execution of p is required for the execution of q. http://purl.obolibrary.org/obo/RO_0002305 causally upstream of, negative effect http://purl.obolibrary.org/obo/RO_0004046 causally upstream of or within, negative effect p is causally upstream of, negative effect q iff p is casually upstream of q, and the execution of p decreases the execution of q. http://purl.obolibrary.org/obo/RO_HOM0000002 in homoplasy relationship with http://purl.obolibrary.org/obo/RO_HOM0000000 in similarity relationship with Similarity that results from independent evolution. http://purl.obolibrary.org/obo/RO_HOM0000003 in homocracy relationship with http://purl.obolibrary.org/obo/RO_0002320 evolutionarily related to Similarity that is characterized by the organization of anatomical structures through the expression of homologous or identical patterning genes. http://purl.obolibrary.org/obo/RO_HOM0000004 in convergence relationship with http://purl.obolibrary.org/obo/RO_HOM0000002 in homoplasy relationship with Homoplasy that involves different underlying mechanisms or structures. http://purl.obolibrary.org/obo/RO_HOM0000005 in parallelism relationship with http://purl.obolibrary.org/obo/RO_HOM0000002 in homoplasy relationship with Homoplasy that involves homologous underlying mechanisms or structures. http://purl.obolibrary.org/obo/RO_HOM0000006 in structural homology relationship with http://purl.obolibrary.org/obo/RO_HOM0000001 in homology relationship with Homology that is defined by similarity with regard to selected structural parameters. http://purl.obolibrary.org/obo/RO_HOM0000007 in historical homology relationship with http://purl.obolibrary.org/obo/RO_HOM0000001 in homology relationship with Homology that is defined by common descent. http://purl.obolibrary.org/obo/RO_HOM0000008 in biological homology relationship with http://purl.obolibrary.org/obo/RO_HOM0000001 in homology relationship with Homology that is defined by sharing of a set of developmental constraints, caused by locally acting self-regulatory mechanisms of differentiation, between individualized parts of the phenotype. http://purl.obolibrary.org/obo/RO_HOM0000009 in reversal relationship with http://purl.obolibrary.org/obo/RO_HOM0000002 in homoplasy relationship with Homoplasy that involves phenotypes similar to those seen in ancestors within the lineage. http://purl.obolibrary.org/obo/RO_HOM0000010 in syntenic homology relationship with http://purl.obolibrary.org/obo/RO_HOM0000006 in structural homology relationship with Structural homology that is detected by similarity in content and organization between chromosomes. http://purl.obolibrary.org/obo/RO_HOM0000011 in paralogy relationship with http://purl.obolibrary.org/obo/RO_HOM0000007 in historical homology relationship with Historical homology that involves genes that diverged after a duplication event. http://purl.obolibrary.org/obo/RO_HOM0000012 in syntenic paralogy relationship with http://purl.obolibrary.org/obo/RO_HOM0000011 in paralogy relationship with Paralogy that involves sets of syntenic blocks. http://purl.obolibrary.org/obo/RO_HOM0000013 in syntenic orthology relationship with http://purl.obolibrary.org/obo/RO_HOM0000010 in syntenic homology relationship with Syntenic homology that involves chromosomes of different species. http://purl.obolibrary.org/obo/RO_HOM0000014 in partial homology relationship with http://purl.obolibrary.org/obo/RO_HOM0000006 in structural homology relationship with Structural homology that involves complex structures from which only a fraction of the elements that can be isolated are separately homologous. http://purl.obolibrary.org/obo/RO_HOM0000015 in protein structural homology relationship with http://purl.obolibrary.org/obo/RO_HOM0000006 in structural homology relationship with Structural homology that is detected at the level of the 3D protein structure, but maybe not at the level of the amino acid sequence. http://purl.obolibrary.org/obo/RO_HOM0000017 in orthology relationship with http://purl.obolibrary.org/obo/RO_HOM0000007 in historical homology relationship with Historical homology that involves genes that diverged after a speciation event. http://purl.obolibrary.org/obo/RO_HOM0000018 in xenology relationship with http://purl.obolibrary.org/obo/RO_HOM0000007 in historical homology relationship with Historical homology that is characterized by an interspecies (horizontal) transfer since the common ancestor. http://purl.obolibrary.org/obo/RO_HOM0000019 in 1 to 1 homology relationship with http://purl.obolibrary.org/obo/RO_HOM0000007 in historical homology relationship with Historical homology that involves two members sharing no other homologs in the lineages considered. http://purl.obolibrary.org/obo/RO_HOM0000020 in 1 to 1 orthology relationship with http://purl.obolibrary.org/obo/RO_HOM0000019 in 1 to 1 homology relationship with Orthology that involves two genes that did not experience any duplication after the speciation event that created them. http://purl.obolibrary.org/obo/RO_HOM0000022 in ohnology relationship with http://purl.obolibrary.org/obo/RO_HOM0000011 in paralogy relationship with Paralogy that results from a whole genome duplication event. http://purl.obolibrary.org/obo/RO_HOM0000023 in in-paralogy relationship with http://purl.obolibrary.org/obo/RO_HOM0000011 in paralogy relationship with Paralogy that results from a lineage-specific duplication subsequent to a given speciation event. http://purl.obolibrary.org/obo/RO_HOM0000024 in out-paralogy relationship with http://purl.obolibrary.org/obo/RO_HOM0000011 in paralogy relationship with Paralogy that results from a duplication preceding a given speciation event. http://purl.obolibrary.org/obo/RO_HOM0000025 in pro-orthology relationship with http://purl.obolibrary.org/obo/RO_HOM0000034 in 1 to many orthology relationship with 1:many orthology that involves a gene in species A and one of its ortholog in species B, when duplications more recent than the species split have occurred in species B but not in species A. http://purl.obolibrary.org/obo/RO_HOM0000026 in semi-orthology relationship with http://purl.obolibrary.org/obo/RO_HOM0000034 in 1 to many orthology relationship with 1:many orthology that involves a gene in species A and its ortholog in species B, when duplications more recent than the species split have occurred in species A but not in species B. http://purl.obolibrary.org/obo/RO_HOM0000027 in serial homology relationship with http://purl.obolibrary.org/obo/RO_HOM0000066 in iterative homology relationship with Iterative homology that involves structures arranged along the main body axis. http://purl.obolibrary.org/obo/RO_HOM0000028 in heterochronous homology relationship with http://purl.obolibrary.org/obo/RO_HOM0000008 in biological homology relationship with Biological homology that is characterized by changes, over evolutionary time, in the rate or timing of developmental events of homologous structures. http://purl.obolibrary.org/obo/RO_HOM0000029 in paedomorphorsis relationship with http://purl.obolibrary.org/obo/RO_HOM0000028 in heterochronous homology relationship with Heterochronous homology that is produced by a retention in adults of a species of traits previously seen only in juveniles. http://purl.obolibrary.org/obo/RO_HOM0000030 in peramorphosis relationship with http://purl.obolibrary.org/obo/RO_HOM0000028 in heterochronous homology relationship with Heterochronous homology that is produced by a maturation of individuals of a species past adulthood, which take on hitherto unseen traits. http://purl.obolibrary.org/obo/RO_HOM0000031 in progenesis relationship with http://purl.obolibrary.org/obo/RO_HOM0000029 in paedomorphorsis relationship with Paedomorphosis that is produced by precocious sexual maturation of an organism still in a morphologically juvenile stage. http://purl.obolibrary.org/obo/RO_HOM0000032 in neoteny relationship with http://purl.obolibrary.org/obo/RO_HOM0000029 in paedomorphorsis relationship with Paedomorphosis that is produced by a retardation of somatic development. http://purl.obolibrary.org/obo/RO_HOM0000033 in mimicry relationship with http://purl.obolibrary.org/obo/RO_HOM0000004 in convergence relationship with Convergence that results from co-evolution usually involving an evolutionary arms race. http://purl.obolibrary.org/obo/RO_HOM0000034 in 1 to many orthology relationship with http://purl.obolibrary.org/obo/RO_HOM0000037 in 1 to many homology relationship with Orthology that involves two genes when duplications more recent than the species split have occurred in one species but not the other. http://purl.obolibrary.org/obo/RO_HOM0000036 in many to many homology relationship with http://purl.obolibrary.org/obo/RO_HOM0000007 in historical homology relationship with Historical homology that involves two members of a larger set of homologs. http://purl.obolibrary.org/obo/RO_HOM0000037 in 1 to many homology relationship with http://purl.obolibrary.org/obo/RO_HOM0000007 in historical homology relationship with Historical homology that involves a structure that has no other homologs in the species in which it is defined, and several homologous structures in another species. http://purl.obolibrary.org/obo/RO_HOM0000042 in apomorphy relationship with http://purl.obolibrary.org/obo/RO_HOM0000007 in historical homology relationship with Historical homology that is based on recent shared ancestry, characterizing a monophyletic group. http://purl.obolibrary.org/obo/RO_HOM0000043 in plesiomorphy relationship with http://purl.obolibrary.org/obo/RO_HOM0000007 in historical homology relationship with Historical homology that is based on distant shared ancestry. http://purl.obolibrary.org/obo/RO_HOM0000044 in deep homology relationship with http://purl.obolibrary.org/obo/RO_HOM0000005 in parallelism relationship with Homocracy that involves morphologically and phylogenetically disparate structures that are the result of parallel evolution. http://purl.obolibrary.org/obo/RO_HOM0000045 in hemiplasy relationship with http://purl.obolibrary.org/obo/RO_HOM0000007 in historical homology relationship with Historical homology that is characterized by topological discordance between a gene tree and a species tree attributable to the phylogenetic sorting of genetic polymorphisms across successive nodes in a species tree. http://purl.obolibrary.org/obo/RO_HOM0000046 in gametology relationship with http://purl.obolibrary.org/obo/RO_HOM0000047 in chromosomal homology relationship with Historical homology that involves not recombining and subsequently differentiated sex chromosomes. http://purl.obolibrary.org/obo/RO_HOM0000047 in chromosomal homology relationship with http://purl.obolibrary.org/obo/RO_HOM0000007 in historical homology relationship with Historical homology that involves the chromosomes able to pair (synapse) during meiosis. http://purl.obolibrary.org/obo/RO_HOM0000048 in many to many orthology relationship with http://purl.obolibrary.org/obo/RO_HOM0000036 in many to many homology relationship with Orthology that involves two genes that experienced duplications more recent than the species split that created them. http://purl.obolibrary.org/obo/RO_HOM0000049 in within-species paralogy relationship with http://purl.obolibrary.org/obo/RO_HOM0000011 in paralogy relationship with Paralogy that involves genes from the same species. http://purl.obolibrary.org/obo/RO_HOM0000050 in between-species paralogy relationship with http://purl.obolibrary.org/obo/RO_HOM0000011 in paralogy relationship with Paralogy that involves genes from different species. http://purl.obolibrary.org/obo/RO_HOM0000051 in postdisplacement relationship with http://purl.obolibrary.org/obo/RO_HOM0000029 in paedomorphorsis relationship with Paedomorphosis that is produced by delayed growth of immature structures into the adult form. http://purl.obolibrary.org/obo/RO_HOM0000052 in hypermorphosis relationship with http://purl.obolibrary.org/obo/RO_HOM0000030 in peramorphosis relationship with Peramorphosis that is produced by a delay in the offset of development. http://purl.obolibrary.org/obo/RO_HOM0000053 in synology relationship with http://purl.obolibrary.org/obo/RO_HOM0000018 in xenology relationship with Xenology that results, not from the transfer of a gene between two species, but from a hybridization of two species. http://purl.obolibrary.org/obo/RO_HOM0000054 in isoorthology relationship with http://purl.obolibrary.org/obo/RO_HOM0000062 in equivalogy relationship with Orthology that involves functional equivalent genes with retention of the ancestral function. http://purl.obolibrary.org/obo/RO_HOM0000055 in tandem paralogy relationship with http://purl.obolibrary.org/obo/RO_HOM0000011 in paralogy relationship with Paralogy that is characterized by duplication of adjacent sequences on a chromosome segment. http://purl.obolibrary.org/obo/RO_HOM0000057 in latent homology relationship with http://purl.obolibrary.org/obo/RO_HOM0000058 in syngeny relationship with Parallelism that involves morphologically very similar structures, occurring only within some members of a taxon and absent in the common ancestor (which possessed the developmental basis to develop this character). http://purl.obolibrary.org/obo/RO_HOM0000058 in syngeny relationship with http://purl.obolibrary.org/obo/RO_HOM0000003 in homocracy relationship with Homocracy that involves recognizably corresponding characters that occurs in two or more taxa, or as a repeated unit within an individual. http://purl.obolibrary.org/obo/RO_HOM0000060 in apparent orthology relationship with http://purl.obolibrary.org/obo/RO_HOM0000050 in between-species paralogy relationship with Between-species paralogy that involves single copy paralogs resulting from reciprocal gene loss. http://purl.obolibrary.org/obo/RO_HOM0000061 in pseudoparalogy relationship with http://purl.obolibrary.org/obo/RO_HOM0000018 in xenology relationship with Xenology that involves genes that ended up in a given genome as a result of a combination of vertical inheritance and horizontal gene transfer. http://purl.obolibrary.org/obo/RO_HOM0000062 in equivalogy relationship with http://purl.obolibrary.org/obo/RO_HOM0000065 in functional equivalence relationship with Historical homology that involves functional equivalent genes with retention of the ancestral function. http://purl.obolibrary.org/obo/RO_HOM0000063 in interology relationship with http://purl.obolibrary.org/obo/RO_HOM0000007 in historical homology relationship with Historical homology that involves orthologous pairs of interacting molecules in different organisms. http://purl.obolibrary.org/obo/RO_HOM0000065 in functional equivalence relationship with http://purl.obolibrary.org/obo/RO_HOM0000000 in similarity relationship with Similarity that is characterized by interchangeability in function. http://purl.obolibrary.org/obo/RO_HOM0000066 in iterative homology relationship with http://purl.obolibrary.org/obo/RO_HOM0000008 in biological homology relationship with Biological homology that involves parts of the same organism. http://purl.obolibrary.org/obo/RO_HOM0000068 in paraxenology relationship with http://purl.obolibrary.org/obo/RO_HOM0000018 in xenology relationship with Xenology that is characterized by multiple horizontal transfer events, resulting in the presence of two or more copies of the foreign gene in the host genome. http://purl.obolibrary.org/obo/RO_HOM0000069 in plerology relationship with http://purl.obolibrary.org/obo/RO_HOM0000011 in paralogy relationship with Paralogy that is characterized by extra similarity between paralogous sequences resulting from concerted evolution. http://purl.obolibrary.org/obo/RO_HOM0000071 in homotopy relationship with http://purl.obolibrary.org/obo/RO_HOM0000006 in structural homology relationship with Structural homology that involves structures with the same or similar relative positions. http://purl.obolibrary.org/obo/RO_HOM0000072 in homeosis relationship with http://purl.obolibrary.org/obo/RO_HOM0000008 in biological homology relationship with Biological homology that involves an ectopic structure and the normally positioned structure. http://purl.obolibrary.org/obo/RO_HOM0000073 in homoeology relationship with http://purl.obolibrary.org/obo/RO_HOM0000053 in synology relationship with Synology that results from allopolyploidy. http://purl.obolibrary.org/obo/RO_HOM0000074 in paramorphism relationship with http://purl.obolibrary.org/obo/RO_HOM0000066 in iterative homology relationship with Iterative homology that involves two structures, one of which originated as a duplicate of the other and co-opted the expression of patterning genes of the ancestral structure. http://purl.obolibrary.org/obo/RO_HOM0000075 in regulogy relationship with http://purl.obolibrary.org/obo/RO_HOM0000007 in historical homology relationship with Historical homology that involves orthologous pairs of transcription factors and downstream regulated genes in different organisms. http://purl.obolibrary.org/obo/RO_0020337 has constituent monomer http://purl.obolibrary.org/obo/RO_0002180 has component A relation that holds between a polymer and its constituent monomers. P has_constituent_monomer 'm' if and only if P has_component multiple instances of 'm' and each instance of 'm' is covalently attached to another instance of 'm'. http://purl.obolibrary.org/obo/RO_0020339 non-covalently bound to http://purl.obolibrary.org/obo/RO_0002436 molecularly interacts with A relation that holds between two distinct chemical entities that are held in close proximity to each other specifically via the force of non-covalent interactions. http://purl.obolibrary.org/obo/RO_0002131 overlaps http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to x overlaps y if and only if there exists some z such that x has part z and z part of y http://purl.obolibrary.org/obo/RO_0002254 has developmental contribution from http://purl.obolibrary.org/obo/RO_0002258 developmentally preceded by x has developmental contribution from y iff x has some part z such that z develops from y http://purl.obolibrary.org/obo/RO_0002496 existence starts during or after http://purl.obolibrary.org/obo/RO_0002487 relation between physical entity and a process or stage x existence starts during or after y if and only if the time point at which x starts is after or equivalent to the time point at which y starts. Formally: x existence starts during or after y iff α (x) >= α (y). http://purl.obolibrary.org/obo/RO_0002497 existence ends during or before http://purl.obolibrary.org/obo/RO_0002487 relation between physical entity and a process or stage x existence ends during or before y if and only if the time point at which x ends is before or equivalent to the time point at which y ends. http://purl.obolibrary.org/obo/RO_0000091 has disposition http://purl.obolibrary.org/obo/RO_0000053 has characteristic a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence http://purl.obolibrary.org/obo/RO_0000092 disposition of http://purl.obolibrary.org/obo/RO_0000052 characteristic of inverse of has disposition http://purl.obolibrary.org/obo/RO_0011002 regulates activity of http://purl.obolibrary.org/obo/RO_0002566 causally influences The entity A has an activity that regulates an activity of the entity B. For example, A and B are gene products where the catalytic activity of A regulates the kinase activity of B. http://purl.obolibrary.org/obo/RO_0011003 regulates quantity of http://purl.obolibrary.org/obo/RO_0002566 causally influences The entity A has an activity that regulates the quantity or abundance or concentration of the entity B. http://purl.obolibrary.org/obo/RO_0011004 indirectly regulates activity of http://purl.obolibrary.org/obo/RO_0011002 regulates activity of The entity A is not immediately upstream of the entity B but A has an activity that regulates an activity performed by B. http://purl.obolibrary.org/obo/RO_0011007 decreases by repression quantity of http://purl.obolibrary.org/obo/RO_0011023 indirectly negatively regulates quantity of The entity A has an activity that down-regulates by repression the quantity of B. The down-regulation is due to A having an effect on an intermediate entity (typically a DNA or mRNA element) which can produce B. For example, protein A (transcription factor) indirectly decreases by repression the quantity of protein B (gene product) if and only if A negatively regulates the process of transcription or translation of a nucleic acid element that produces B. http://purl.obolibrary.org/obo/RO_0011008 increases by expression quantity of http://purl.obolibrary.org/obo/RO_0011024 indirectly positively regulates quantity of The entity A has an activity that up-regulates by expression the quantity of B. The up-regulation is due to A having an effect on an intermediate entity (typically a DNA or mRNA element) which can produce B. For example, protein A (transcription factor) indirectly increases by expression the quantity of protein B (gene product) if and only if A positively regulates the process of transcription or translation of a nucleic acid element that produces B. http://purl.obolibrary.org/obo/RO_0011009 directly positively regulates quantity of http://purl.obolibrary.org/obo/RO_0011021 directly regulates quantity of The entity A has an activity that directly positively regulates the quantity of B. http://purl.obolibrary.org/obo/RO_0011010 directly negatively regulates quantity of http://purl.obolibrary.org/obo/RO_0011021 directly regulates quantity of The entity A has an activity that directly negatively regulates the quantity of B. http://purl.obolibrary.org/obo/RO_0011014 destabilizes quantity of http://purl.obolibrary.org/obo/RO_0011010 directly negatively regulates quantity of An entity A directly interacts with B and A has an activity that decreases the amount of an entity B by degradating it. http://purl.obolibrary.org/obo/RO_0011015 stabilizes quantity of http://purl.obolibrary.org/obo/RO_0011009 directly positively regulates quantity of An entity A physically interacts with B and A has an activity that increases the amount of an entity B by stabilizing it. http://purl.obolibrary.org/obo/RO_0011021 directly regulates quantity of http://purl.obolibrary.org/obo/RO_0011003 regulates quantity of The entity A, immediately upstream of B, has an activity that directly regulates the quantity of B. http://purl.obolibrary.org/obo/RO_0011022 indirectly regulates quantity of http://purl.obolibrary.org/obo/RO_0011003 regulates quantity of The entity A is not immediately upstream of the entity B, but A has an activity that regulates the quantity or abundance or concentration of B. http://purl.obolibrary.org/obo/RO_0011023 indirectly negatively regulates quantity of http://purl.obolibrary.org/obo/RO_0011022 indirectly regulates quantity of The entity A does not physically interact with the entity B, and A has an activity that down-regulates the quantity or abundance or concentration of B. http://purl.obolibrary.org/obo/RO_0011024 indirectly positively regulates quantity of http://purl.obolibrary.org/obo/RO_0011022 indirectly regulates quantity of The entity A does not physically interact with the entity B, and A has an activity that up-regulates the quantity or abundance or concentration of B. http://purl.obolibrary.org/obo/RO_0012000 has small molecule regulator http://purl.obolibrary.org/obo/RO_0000057 has participant a relation between a process and a continuant, in which the process is regulated by the small molecule continuant http://purl.obolibrary.org/obo/RO_0012001 has small molecule activator http://purl.obolibrary.org/obo/RO_0012000 has small molecule regulator a relation between a process and a continuant, in which the process is activated by the small molecule continuant http://purl.obolibrary.org/obo/RO_0012002 has small molecule inhibitor http://purl.obolibrary.org/obo/RO_0012000 has small molecule regulator a relation between a process and a continuant, in which the process is inhibited by the small molecule continuant http://purl.obolibrary.org/obo/RO_0012003 acts on population of http://purl.obolibrary.org/obo/RO_0000057 has participant p acts on population of c iff c' is a collection, has members of type c, and p has participant c http://purl.obolibrary.org/obo/RO_0012004 is small molecule regulator of http://purl.obolibrary.org/obo/RO_0002596 capable of regulating a relation between a continuant and a process, in which the continuant is a small molecule that regulates the process http://purl.obolibrary.org/obo/RO_0012005 is small molecule activator of http://purl.obolibrary.org/obo/RO_0002598 capable of positively regulating a relation between a continuant and a process, in which the continuant is a small molecule that activates the process http://purl.obolibrary.org/obo/RO_0012006 is small molecule inhibitor of http://purl.obolibrary.org/obo/RO_0002597 capable of negatively regulating a relation between a continuant and a process, in which the continuant is a small molecule that inhibits the process http://purl.obolibrary.org/obo/RO_0013001 has synaptic IO in region http://purl.obolibrary.org/obo/RO_0002130 has synaptic terminal in A relationship between a neuron and a region, where the neuron has a functionally relevant number of input and/or output synapses in that region. http://purl.obolibrary.org/obo/RO_0013002 receives synaptic input in region http://purl.obolibrary.org/obo/RO_0002110 has postsynaptic terminal in A relationship between a neuron and a region, where the neuron has a functionally relevant number of input synapses in that region. http://purl.obolibrary.org/obo/RO_0013003 sends synaptic output to region http://purl.obolibrary.org/obo/RO_0002113 has presynaptic terminal in A relationship between a neuron and a region, where the neuron has a functionally relevant number of output synapses in that region. http://purl.obolibrary.org/obo/RO_0013004 has synaptic IO throughout http://purl.obolibrary.org/obo/RO_0013001 has synaptic IO in region A relationship between a neuron and a region, where the neuron has a functionally relevant number of input and/or output synapses distributed throughout that region (rather than confined to a subregion). http://purl.obolibrary.org/obo/RO_0013005 receives synaptic input throughout http://purl.obolibrary.org/obo/RO_0013004 has synaptic IO throughout A relationship between a neuron and a region, where the neuron has a functionally relevant number of input synapses distributed throughout that region (rather than confined to a subregion). http://purl.obolibrary.org/obo/RO_0013006 sends synaptic output throughout http://purl.obolibrary.org/obo/RO_0013004 has synaptic IO throughout A relationship between a neuron and a region, where the neuron has a functionally relevant number output synapses distributed throughout that region (rather than confined to a subregion). http://purl.obolibrary.org/obo/RO_0002411 causally upstream of http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within p is causally upstream of q iff p is causally related to q, the end of p precedes the end of q, and p is not an occurrent part of q. http://purl.obolibrary.org/obo/RO_0008509 has roost http://purl.obolibrary.org/obo/RO_0002303 has habitat x 'has roost' y if and only if: x is an organism, y is a habitat, and y can support rest behaviors x. http://purl.obolibrary.org/obo/RO_0018031 is direct conjugate base of http://purl.obolibrary.org/obo/RO_0018033 is deprotonated form of A is a direct conjugate base of B if and only if A is chemical entity that is a Brønsted–Lowry Base (i.e., can receive a proton) and by receiving a particular proton transforms it into B. http://purl.obolibrary.org/obo/RO_0018032 is direct conjugate acid of http://purl.obolibrary.org/obo/RO_0018034 is protonated form of A is a direct conjugate acid of B if and only if A is chemical entity that is a Brønsted–Lowry Acid (i.e., can give up a proton) and by removing a particular proton transforms it into B. http://purl.obolibrary.org/obo/RO_0018033 is deprotonated form of http://purl.obolibrary.org/obo/RO_0018030 chemical relationship A is a deprotonated form of B if and only if A is chemical entity that is a Brønsted–Lowry Base (i.e., can receive a proton) and by adding some nonzero number of protons transforms it into B. This is a transitive relationship and follows this design pattern: https://oborel.github.io/obo-relations/direct-and-indirect-relations. http://purl.obolibrary.org/obo/RO_0018034 is protonated form of http://purl.obolibrary.org/obo/RO_0018030 chemical relationship A is a protonated form of B if and only if A is chemical entity that is a Brønsted–Lowry Acid (i.e., can give up a proton) and by removing some nonzero number of protons transforms it into B. This is a transitive relationship and follows this design pattern: https://oborel.github.io/obo-relations/direct-and-indirect-relations. http://purl.obolibrary.org/obo/RO_0018035 is matched small molecular pair with http://purl.obolibrary.org/obo/RO_0018030 chemical relationship A and B are a matched small molecular pair (MMP) if their chemical structures define by a single, relatively small, well-defined structural modification. While this is normally called "matched molecular pair" in the cheminformatics literaturel, it is labeled as "matched small molecular pair" so as to reduce confusion with peptides and other macromolecules, which are also referenced as "molecules" in some contexts. This relationship is symmetric, meaning if A is a MMP with B iff B is a MMP with A. This relationship is not transitive, meaning that A is a MMP with B and B is a MMP with C, then A is not necessarily an MMP with C. http://purl.obolibrary.org/obo/RO_0018036 is tautomer of http://purl.obolibrary.org/obo/RO_0018030 chemical relationship Two chemicals are tautomers if they can be readily interconverted. This commonly refers to prototropy in which a hydrogen's position is changed, such as between ketones and enols. This is also often observed in heterocyclic rings, e.g., ones containing nitrogens and/or have aryl functional groups containing heteroatoms. http://purl.obolibrary.org/obo/RO_0018037 is substitutent group from http://purl.obolibrary.org/obo/RO_0018030 chemical relationship Group A is a substituent group from Chemical B if A represents the functional part of A and includes information about where it is connected. A is not itself a chemical with a fully formed chemical graph, but is rather a partial graph with one or more connection points that can be used to attach to another chemical graph, typically as a functionalization. http://purl.obolibrary.org/obo/RO_0018038 has functional parent http://purl.obolibrary.org/obo/RO_0018030 chemical relationship Chemical A has functional parent Chemical B if there is chemical transformation through which chemical B can be produced from chemical A. For example, the relationship between a salt and a freebased compound is a "has functional parent" relationship. http://purl.obolibrary.org/obo/RO_0018039 is enantiomer of http://purl.obolibrary.org/obo/RO_0018030 chemical relationship Chemicals A and B are enantiomers if they share the same molecular graph except the change of the configuration of substituents around exactly one chiral center. A chemical with no chiral centers can not have an enantiomer. A chemical with multiple chiral centers can have multiple enantiomers, but its enantiomers are not themselves enantiomers (they are diastereomers). http://purl.obolibrary.org/obo/RO_0018040 has parent hydride http://purl.obolibrary.org/obo/RO_0018030 chemical relationship Chemical A has parent hydride Chemical B if there exists a molecular graphical transformation where functional groups on A are replaced with hydrogens in order to yield B. http://purl.obolibrary.org/obo/RO_0002211 regulates http://purl.obolibrary.org/obo/RO_0002411 causally upstream of p regulates q iff p is causally upstream of q, the execution of p is not constant and varies according to specific conditions, and p influences the rate or magnitude of execution of q due to an effect either on some enabler of q or some enabler of a part of q. http://purl.obolibrary.org/obo/RO_0002212 negatively regulates http://purl.obolibrary.org/obo/RO_0002211 regulates p negatively regulates q iff p regulates q, and p decreases the rate or magnitude of execution of q. http://purl.obolibrary.org/obo/RO_0002213 positively regulates http://purl.obolibrary.org/obo/RO_0002211 regulates p positively regulates q iff p regulates q, and p increases the rate or magnitude of execution of q. http://purl.obolibrary.org/obo/RO_0002180 has component http://purl.obolibrary.org/obo/BFO_0000051 has part w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type. http://purl.obolibrary.org/obo/RO_0002163 spatially disjoint from http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to A is spatially_disjoint_from B if and only if they have no parts in common http://purl.obolibrary.org/obo/RO_0002352 input of http://purl.obolibrary.org/obo/RO_0002328 functionally related to inverse of has input http://purl.obolibrary.org/obo/RO_0002353 output of http://purl.obolibrary.org/obo/RO_0002328 functionally related to inverse of has output http://purl.obolibrary.org/obo/RO_0002473 composed primarily of http://purl.obolibrary.org/obo/BFO_0000051 has part x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y. http://purl.obolibrary.org/obo/RO_0002104 has plasma membrane part http://purl.obolibrary.org/obo/BFO_0000051 has part Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part. http://purl.obolibrary.org/obo/RO_0002203 develops into http://purl.obolibrary.org/obo/RO_0002387 has potential to develop into inverse of develops from http://purl.obolibrary.org/obo/RO_0002387 has potential to develop into http://purl.obolibrary.org/obo/RO_0002384 has developmental potential involving x has the potential to develop into y iff x develops into y or if x is capable of developing into y http://purl.obolibrary.org/obo/RO_0002020 transports http://purl.obolibrary.org/obo/RO_0002313 transports or maintains localization of Holds between p and c when p is a transport process or transporter activity and the outcome of this p is to move c from one location to another. http://purl.obolibrary.org/obo/RO_0002021 occurs across http://purl.obolibrary.org/obo/RO_0002479 has part that occurs in A relationship between a process and a barrier, where the process occurs in a region spanning the barrier. For cellular processes the barrier is typically a membrane. Examples include transport across a membrane and membrane depolarization. http://purl.obolibrary.org/obo/RO_0002023 directly negatively regulated by http://purl.obolibrary.org/obo/RO_0002022 directly regulated by Process(P2) is directly negatively regulated by process(P1) iff: P1 negatively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding negatively regulates the kinase activity (P2) of protein B then P2 directly negatively regulated by P1. http://purl.obolibrary.org/obo/RO_0002024 directly positively regulated by http://purl.obolibrary.org/obo/RO_0002022 directly regulated by Process(P2) is directly postively regulated by process(P1) iff: P1 positively regulates P2 via direct physical interaction between an agent executing P1 (or some part of P1) and an agent executing P2 (or some part of P2). For example, if protein A has protein binding activity(P1) that targets protein B and this binding positively regulates the kinase activity (P2) of protein B then P2 is directly postively regulated by P1. http://purl.obolibrary.org/obo/RO_0015007 increased in magnitude relative to http://purl.obolibrary.org/obo/RO_0015006 different in magnitude relative to q1 increased_in_magnitude_relative_to q2 if and only if magnitude(q1) > magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. http://purl.obolibrary.org/obo/RO_0020202 has numerator http://purl.obolibrary.org/obo/BFO_0000051 has part A relationship between a ratio or proportion and its dividend. http://purl.obolibrary.org/obo/RO_0020203 has denominator http://purl.obolibrary.org/obo/BFO_0000051 has part A relationship between a ratio or proportion and its divisor. http://purl.obolibrary.org/obo/RO_0008510 symbiotrophically interacts with http://purl.obolibrary.org/obo/RO_0002438 trophically interacts with A trophic interaction in which one organism acquires nutrients through a symbiotic relationship with another organism http://purl.obolibrary.org/obo/RO_0008511 trophic parasite of http://purl.obolibrary.org/obo/RO_0008510 symbiotrophically interacts with A symbiotrophic interaction in which one organism acquires nutrients through a parasitic relationship with another organism http://purl.obolibrary.org/obo/RO_0013010 synapses restricted to region http://purl.obolibrary.org/obo/RO_0013001 has synaptic IO in region A relationship between a neuron and a region, where all of the functionally relevant input and output synapses are in that region. http://purl.obolibrary.org/obo/RO_0020301 has allelopath http://purl.obolibrary.org/obo/RO_0002574 participates in a biotic-biotic interaction with inverse of allelopath of http://purl.obolibrary.org/obo/RO_0002801 co-roosts with http://purl.obolibrary.org/obo/RO_0008506 ecologically co-occurs with Two or more individuals sharing the same roost site (cave, mine, tree or tree hollow, animal burrow, leaf tent, rock crack, space in man-made structure, etc.). Individuals that are sharing a communal roost may be said to be co-roosting. The roost may be either a day roost where the individuals rest during daytime hours, or a night roost where individuals roost to feed, groom, or rest in between flights and/or foraging bouts. Communal roosting as thus defined is an umbrella term within which different specialized types -- which are not mutually exclusive -- may be recognized based on taxonomy and the temporal and spatial relationships of the individuals that are co-roosting. http://purl.obolibrary.org/obo/RO_0013009 sends synaptic output to cell http://purl.obolibrary.org/obo/RO_0002120 synapsed to A relationship between a neuron and a cell that it has a functionally relevant number of chemical synapses to. http://purl.obolibrary.org/obo/RO_0015008 decreased in magnitude relative to http://purl.obolibrary.org/obo/RO_0015006 different in magnitude relative to q1 decreased_in_magnitude_relative_to q2 if and only if magnitude(q1) < magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. http://purl.obolibrary.org/obo/RO_0012011 indirectly causally upstream of http://purl.obolibrary.org/obo/RO_0002411 causally upstream of p is indirectly causally upstream of q iff p is causally upstream of q and there exists some process r such that p is causally upstream of r and r is causally upstream of q. http://purl.obolibrary.org/obo/RO_0012012 indirectly regulates http://purl.obolibrary.org/obo/RO_0012011 indirectly causally upstream of p indirectly regulates q iff p is indirectly causally upstream of q and p regulates q. http://purl.obolibrary.org/obo/RO_0002007 bounding layer of http://purl.obolibrary.org/obo/BFO_0000050 part of X outer_layer_of Y iff: . X :continuant that bearer_of some PATO:laminar . X part_of Y . exists Z :surface . X has_boundary Z . Z boundary_of Y has_boundary: http://purl.obolibrary.org/obo/RO_0002002 boundary_of: http://purl.obolibrary.org/obo/RO_0002000 http://purl.obolibrary.org/obo/RO_0002008 coincident with http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to A relation that holds between two linear structures that are approximately parallel to each other for their entire length and where either the two structures are adjacent to each other or one is part of the other. http://purl.obolibrary.org/obo/RO_0002170 connected to http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to a is connected to b if and only if a and b are discrete structure, and there exists some connecting structure c, such that c connects a and b http://purl.obolibrary.org/obo/RO_0002177 attached to part of http://purl.obolibrary.org/obo/RO_0002567 biomechanically related to a is attached to part of b if a is attached to b, or a is attached to some p, where p is part of b. http://purl.obolibrary.org/obo/RO_0002179 drains http://purl.obolibrary.org/obo/RO_0002170 connected to Relation between an collecting structure and another structure, where the collecting structure acts as a conduit channeling fluid, substance or energy away from the other structure. http://purl.obolibrary.org/obo/RO_0002264 acts upstream of or within http://purl.obolibrary.org/obo/RO_0002500 causal agent in process c acts upstream of or within p if c is enables f, and f is causally upstream of or within p. c is a material entity and p is an process. http://purl.obolibrary.org/obo/RO_0002375 in branching relationship with http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to A relationship that holds between two material entities in a system of connected structures, where the branching relationship holds based on properties of the connecting network. http://purl.obolibrary.org/obo/RO_0002438 trophically interacts with http://purl.obolibrary.org/obo/RO_0002574 participates in a biotic-biotic interaction with An interaction relationship in which the partners are related via a feeding relationship. http://purl.obolibrary.org/obo/RO_0002457 acquires nutrients from http://purl.obolibrary.org/obo/RO_0002437 biotically interacts with Inverse of provides nutrients for http://purl.obolibrary.org/obo/RO_0002469 provides nutrients for http://purl.obolibrary.org/obo/RO_0002437 biotically interacts with A biotic interaction where a material entity provides nutrition for an organism. http://purl.obolibrary.org/obo/RO_0002503 towards http://purl.obolibrary.org/obo/RO_0002502 depends on q towards e2 if and only if q is a relational quality such that q inheres-in some e, and e != e2 and q is dependent on e2 http://purl.obolibrary.org/obo/RO_0002567 biomechanically related to http://purl.obolibrary.org/obo/RO_0002328 functionally related to A relation that holds between elements of a musculoskeletal system or its analogs. http://purl.obolibrary.org/obo/RO_0002003 electrically_synapsed_to http://purl.obolibrary.org/obo/RO_0002170 connected to A relation that holds between two neurons that are electrically coupled via gap junctions. http://purl.obolibrary.org/obo/RO_0002004 tracheates http://purl.obolibrary.org/obo/RO_0001025 located in The relationship that holds between a trachea or tracheole and an antomical structure that is contained in (and so provides an oxygen supply to). http://purl.obolibrary.org/obo/RO_0002105 synapsed_via_type_Ib_bouton_to http://purl.obolibrary.org/obo/RO_0002120 synapsed to A relation between a motor neuron and a muscle that it synapses to via a type Ib bouton. http://purl.obolibrary.org/obo/RO_0002106 synapsed_via_type_Is_bouton_to http://purl.obolibrary.org/obo/RO_0002120 synapsed to A relation between a motor neuron and a muscle that it synapses to via a type Is bouton. http://purl.obolibrary.org/obo/RO_0002107 synapsed_via_type_II_bouton_to http://purl.obolibrary.org/obo/RO_0002120 synapsed to A relation between a motor neuron and a muscle that it synapses to via a type II bouton. http://purl.obolibrary.org/obo/RO_0002108 synapsed_by_via_type_II_bouton http://purl.obolibrary.org/obo/RO_0002103 synapsed by Relation between a muscle and a motor neuron that synapses to it via a type II bouton. http://purl.obolibrary.org/obo/RO_0002109 synapsed_by_via_type_Ib_bouton http://purl.obolibrary.org/obo/RO_0002103 synapsed by Relation between a muscle and a motor neuron that synapses to it via a type Ib bouton. http://purl.obolibrary.org/obo/RO_0002112 synapsed_by_via_type_Is_bouton http://purl.obolibrary.org/obo/RO_0002103 synapsed by Relation between a muscle and a motor neuron that synapses to it via a type Is bouton. http://purl.obolibrary.org/obo/RO_0002114 synapsed_via_type_III_bouton_to http://purl.obolibrary.org/obo/RO_0002120 synapsed to A relation between a motor neuron and a muscle that it synapses to via a type III bouton. http://purl.obolibrary.org/obo/RO_0002115 synapsed_by_via_type_III_bouton http://purl.obolibrary.org/obo/RO_0002103 synapsed by Relation between a muscle and a motor neuron that synapses to it via a type III bouton. http://purl.obolibrary.org/obo/RO_0002373 has muscle insertion http://purl.obolibrary.org/obo/RO_0002567 biomechanically related to m has_muscle_insertion s iff m is attaches_to s, and it is the case that when m contracts, s moves. Insertions are usually connections of muscle via tendon to bone. http://purl.obolibrary.org/obo/RO_0002433 contributes to morphology of http://purl.obolibrary.org/obo/RO_0002131 overlaps p contributes to morphology of w if and only if a change in the morphology of p entails a change in the morphology of w. Examples: every skull contributes to morphology of the head which it is a part of. Counter-example: nuclei do not generally contribute to the morphology of the cell they are part of, as they are buffered by cytoplasm. http://purl.obolibrary.org/obo/RO_0002488 existence starts during http://purl.obolibrary.org/obo/RO_0002496 existence starts during or after x existence starts during y if and only if the time point at which x starts is after or equivalent to the time point at which y starts and before or equivalent to the time point at which y ends. Formally: x existence starts during y iff α(x) >= α(y) & α(x) <= ω(y). http://purl.obolibrary.org/obo/RO_0002489 existence starts with http://purl.obolibrary.org/obo/RO_0002488 existence starts during x starts ends with y if and only if the time point at which x starts is equivalent to the time point at which y starts. Formally: x existence starts with y iff α(x) = α(y). http://purl.obolibrary.org/obo/RO_0002492 existence ends during http://purl.obolibrary.org/obo/RO_0002497 existence ends during or before x existence ends during y if and only if the time point at which x ends is before or equivalent to the time point at which y ends and after or equivalent to the point at which y starts. Formally: x existence ends during y iff ω(x) <= ω(y) and ω(x) >= α(y). http://purl.obolibrary.org/obo/RO_0002493 existence ends with http://purl.obolibrary.org/obo/RO_0002492 existence ends during x existence ends with y if and only if the time point at which x ends is equivalent to the time point at which y ends. Formally: x existence ends with y iff ω(x) = ω(y). http://purl.obolibrary.org/obo/RO_0002494 transformation of http://purl.obolibrary.org/obo/RO_0002202 develops from x transformation of y if x is the immediate transformation of y, or is linked to y through a chain of transformation relationships http://purl.obolibrary.org/obo/RO_0002495 immediate transformation of http://purl.obolibrary.org/obo/RO_0002207 directly develops from x immediate transformation of y iff x immediately succeeds y temporally at a time boundary t, and all of the matter present in x at t is present in y at t, and all the matter in y at t is present in x at t http://purl.obolibrary.org/obo/RO_0002507 determined by http://purl.obolibrary.org/obo/RO_0002559 causally influenced by s determined by f if and only if s is a type of system, and f is a material entity that is part of s, such that f exerts a strong causal influence on the functioning of s, and the removal of f would cause the collapse of s. http://purl.obolibrary.org/obo/RO_0002572 luminal space of http://purl.obolibrary.org/obo/RO_0002571 lumen of s is luminal space of x iff s is lumen_of x and s is an immaterial entity http://purl.obolibrary.org/obo/RO_0002576 skeleton of http://purl.obolibrary.org/obo/BFO_0000050 part of inverse of has skeleton http://purl.obolibrary.org/obo/RO_0008501 epiphyte of http://purl.obolibrary.org/obo/RO_0002440 symbiotically interacts with An interaction relationship wherein a plant or algae is living on the outside surface of another plant. http://purl.obolibrary.org/obo/RO_0008502 has epiphyte http://purl.obolibrary.org/obo/RO_0002440 symbiotically interacts with inverse of epiphyte of http://purl.obolibrary.org/obo/RO_0008503 kleptoparasite of http://purl.obolibrary.org/obo/RO_0002444 parasite of A sub-relation of parasite of in which a parasite steals resources from another organism, usually food or nest material http://purl.obolibrary.org/obo/RO_0008504 kleptoparasitized by http://purl.obolibrary.org/obo/RO_0002445 parasitized by inverse of kleptoparasite of http://purl.obolibrary.org/obo/RO_0008505 creates habitat for http://purl.obolibrary.org/obo/RO_0002321 ecologically related to An interaction relationship wherein one organism creates a structure or environment that is lived in by another organism. http://purl.obolibrary.org/obo/RO_0008506 ecologically co-occurs with http://purl.obolibrary.org/obo/RO_0002321 ecologically related to An interaction relationship describing organisms that often occur together at the same time and space or in the same environment. http://purl.obolibrary.org/obo/RO_0008507 lays eggs on http://purl.obolibrary.org/obo/RO_0002618 visits An interaction relationship in which organism a lays eggs on the outside surface of organism b. Organism b is neither helped nor harmed in the process of egg laying or incubation. http://purl.obolibrary.org/obo/RO_0008508 has eggs laid on by http://purl.obolibrary.org/obo/RO_0002619 visited by inverse of lays eggs on http://purl.obolibrary.org/obo/RO_0002019 has ligand http://purl.obolibrary.org/obo/RO_0002233 has input A relationship that holds between between a receptor and an chemical entity, typically a small molecule or peptide, that carries information between cells or compartments of a cell and which binds the receptor and regulates its effector function. http://purl.obolibrary.org/obo/RO_0003309 exacerbates condition http://purl.obolibrary.org/obo/RO_0003305 contributes to severity of condition A relationship between an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) and a condition (a phenotype or disease), where the presence of the entity worsens some or all aspects of the condition. http://purl.obolibrary.org/obo/RO_0003310 condition ameliorated by http://purl.obolibrary.org/obo/RO_0002410 causally related to A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are reduced or eliminated by the presence of the entity. http://purl.obolibrary.org/obo/RO_0003311 condition exacerbated by http://purl.obolibrary.org/obo/RO_0002410 causally related to A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are worsened by the presence of the entity. http://purl.obolibrary.org/obo/RO_0002026 in register with http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to A relationship that holds between two images, A and B, where: A depicts X; B depicts Y; X and Y are both of type T' C is a 2 layer image consiting of layers A and B; A and B are aligned in C according to a shared co-ordinate framework so that common features of X and Y are co-incident with each other. Note: A and B may be 2D or 3D. Examples include: the relationship between two channels collected simultaneously from a confocal microscope; the relationship between an image dpeicting X and a painted annotation layer that delineates regions of X; the relationship between the tracing of a neuron on an EM stack and the co-ordinate space of the stack; the relationship between two separately collected images that have been brought into register via some image registration software. http://purl.obolibrary.org/obo/RO_0004011 is causal gain of function germline mutation of in http://purl.obolibrary.org/obo/RO_0004010 is genetic basis for condition Relates a gene to condition, such that a mutation in this gene in a germ cell provides a new function of the corresponding product and that is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]. http://purl.obolibrary.org/obo/RO_0004012 is causal loss of function germline mutation of in http://purl.obolibrary.org/obo/RO_0004010 is genetic basis for condition Relates a gene to condition, such that a mutation in this gene in a germ cell impairs the function of the corresponding product and that is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]. http://purl.obolibrary.org/obo/RO_0004013 is causal germline mutation in http://purl.obolibrary.org/obo/RO_0004010 is genetic basis for condition Relates a gene to condition, such that a mutation in this gene is sufficient to produce the condition and that can be passed on to offspring[modified from orphanet]. http://purl.obolibrary.org/obo/RO_0004014 is causal somatic mutation in http://purl.obolibrary.org/obo/RO_0004010 is genetic basis for condition Relates a gene to condition, such that a mutation in this gene is sufficient to produce the condition but that cannot be passed on to offspring[modified from orphanet]. http://purl.obolibrary.org/obo/RO_0004015 is causal susceptibility factor for http://purl.obolibrary.org/obo/RO_0004010 is genetic basis for condition Relates a gene to condition, such that a mutation in this gene predisposes to the development of a condition and that is necessary but not sufficient to develop the condition[modified from orphanet]. http://purl.obolibrary.org/obo/RO_0004016 is causal germline mutation partially giving rise to http://purl.obolibrary.org/obo/RO_0004010 is genetic basis for condition Relates a gene to condition, such that a mutation in this gene partially contributes to the presentation of this condition[modified from orphanet]. http://purl.obolibrary.org/obo/RO_0004031 enables subfunction http://purl.obolibrary.org/obo/RO_0002328 functionally related to Holds between an entity and an process P where the entity enables some larger compound process, and that larger process has-part P. http://purl.obolibrary.org/obo/RO_0004034 acts upstream of, positive effect http://purl.obolibrary.org/obo/RO_0004032 acts upstream of or within, positive effect c 'acts upstream of, positive effect' p if c is enables f, and f is causally upstream of p, and the direction of f is positive http://purl.obolibrary.org/obo/RO_0004035 acts upstream of, negative effect http://purl.obolibrary.org/obo/RO_0004033 acts upstream of or within, negative effect c 'acts upstream of, negative effect' p if c is enables f, and f is causally upstream of p, and the direction of f is negative http://purl.obolibrary.org/obo/RO_0018027 is agonist of http://purl.obolibrary.org/obo/RO_0002450 directly positively regulates activity of a relation between a ligand (material entity) and a receptor (material entity) that implies the binding of the ligand to the receptor activates some activity of the receptor http://purl.obolibrary.org/obo/RO_0018028 is inverse agonist of http://purl.obolibrary.org/obo/RO_0002449 directly negatively regulates activity of a relation between a ligand (material entity) and a receptor (material entity) that implies the binding of the ligand to the receptor inhibits some activity of the receptor to below basal level http://purl.obolibrary.org/obo/RO_0018029 is antagonist of http://purl.obolibrary.org/obo/RO_0002449 directly negatively regulates activity of a relation between a ligand (material entity) and a receptor (material entity) that implies the binding of the ligand to the receptor reduces some activity of the receptor to basal level http://purl.obolibrary.org/obo/RO_0002802 reservoir host of http://purl.obolibrary.org/obo/RO_0002453 host of A relation between a host organism and a hosted organism in which the hosted organism naturally occurs in an indefinitely maintained reservoir provided by the host. http://purl.obolibrary.org/obo/RO_0002803 has reservoir host http://purl.obolibrary.org/obo/RO_0002454 has host inverse of reservoir host of http://purl.obolibrary.org/obo/RO_0012013 positively regulates in another organism http://purl.obolibrary.org/obo/RO_0002010 regulates in another organism x 'positively regulates in other organism' y if and only if: (x is the realization of a function to increase the frequency, rate or extent of y) AND (the agents of x are produced by organism o1 and the agents of y are produced by organism o2). http://purl.obolibrary.org/obo/RO_0012014 negatively regulates in another organism http://purl.obolibrary.org/obo/RO_0002010 regulates in another organism x 'negatively regulates in other organism' y if and only if: (x is the realization of a function to reduce the frequency, rate or extent of y) AND (the agents of x are produced by organism o1 and the agents of y are produced by organism o2). http://purl.obolibrary.org/obo/RO_0020101 vessel supplies blood to http://purl.obolibrary.org/obo/RO_0002178 supplies x vessel supplies blood to y if and only if x is a vessel that supplies blood directly or indirectly to an anatomical structure y. http://purl.obolibrary.org/obo/RO_0020102 vessel drains blood from http://purl.obolibrary.org/obo/RO_0002179 drains x vessel drains blood from y if and only if x is a vessel that drains blood directly or indirectly from an anatomical structure y. http://purl.obolibrary.org/obo/RO_0020103 directly supplies and drains http://purl.obolibrary.org/obo/RO_0002179 drains x directly supplies and drains y if and only if x is a capillary, y is an anatomical entity, and x directly supplies and drains y. http://purl.obolibrary.org/obo/RO_0017011 has marker http://purl.obolibrary.org/obo/RO_0002610 correlated with Inverse relation of 'is marker for'. http://purl.obolibrary.org/obo/RO_0002804 ectomycorrhizal host of http://purl.obolibrary.org/obo/RO_0002453 host of x is an ectomycorrhizal host of y if and only if x is a plant (Plantae) whose roots form an intercellular interface (aka Hartig net) with fungus (Fungi) y. This interface consists of highly branched hyphae forming a latticework between epidermal and cortical root cells. http://purl.obolibrary.org/obo/RO_0002805 has ectomycorrhizal host http://purl.obolibrary.org/obo/RO_0002454 has host inverse of ectomycorrhizal host of http://purl.obolibrary.org/obo/RO_0002806 arbuscular mycorrhizal host of http://purl.obolibrary.org/obo/RO_0002453 host of x is an arbuscular mycorrhizal host of y if and only if x is a vascular plant (Plantae) whose cortical cells of the roots are penetrated by fungus (Fungi) y and form arbuscules. http://purl.obolibrary.org/obo/RO_0002807 has arbuscular mycorrhizal host http://purl.obolibrary.org/obo/RO_0002454 has host inverse of arbuscular mycorrhizal host of http://purl.obolibrary.org/obo/RO_0020338 covalently bound to http://purl.obolibrary.org/obo/RO_0002436 molecularly interacts with A relation that holds between two distinct chemical entities that are held in close proximity to each other specifically via the force of covalent interactions. http://purl.obolibrary.org/obo/RO_0002103 synapsed by http://purl.obolibrary.org/obo/RO_0002485 receives input from Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. http://purl.obolibrary.org/obo/RO_0002120 synapsed to http://purl.obolibrary.org/obo/RO_0002486 sends output to Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to. http://purl.obolibrary.org/obo/RO_0002255 developmentally contributes to http://purl.obolibrary.org/obo/RO_0002385 has potential to developmentally contribute to inverse of has developmental contribution from http://purl.obolibrary.org/obo/RO_0002334 regulated by http://purl.obolibrary.org/obo/RO_0002427 causally downstream of or within inverse of regulates http://purl.obolibrary.org/obo/RO_0002335 negatively regulated by http://purl.obolibrary.org/obo/RO_0002334 regulated by inverse of negatively regulates http://purl.obolibrary.org/obo/RO_0002336 positively regulated by http://purl.obolibrary.org/obo/RO_0002334 regulated by inverse of positively regulates http://purl.obolibrary.org/obo/RO_0002379 spatially coextensive with http://purl.obolibrary.org/obo/RO_0002131 overlaps x spatially_coextensive_with y if and inly if x and y have the same location http://purl.obolibrary.org/obo/RO_0002385 has potential to developmentally contribute to http://purl.obolibrary.org/obo/RO_0002384 has developmental potential involving x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y http://purl.obolibrary.org/obo/RO_0002427 causally downstream of or within http://purl.obolibrary.org/obo/RO_0002501 causal relation between processes inverse of causally upstream of or within http://purl.obolibrary.org/obo/RO_0002500 causal agent in process http://purl.obolibrary.org/obo/RO_0002595 causal relation between material entity and a process A relationship between a material entity and a process where the material entity has some causal role that influences the process http://purl.obolibrary.org/obo/RO_0002501 causal relation between processes http://purl.obolibrary.org/obo/RO_0002410 causally related to p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one where the execution of p influences the execution of q. p may be upstream, downstream, part of, or a container of q. http://purl.obolibrary.org/obo/RO_0002584 has part structure that is capable of http://purl.obolibrary.org/obo/RO_0002595 causal relation between material entity and a process s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p http://purl.obolibrary.org/obo/RO_0002595 causal relation between material entity and a process http://purl.obolibrary.org/obo/RO_0002410 causally related to A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity. http://purl.obolibrary.org/obo/RO_0002596 capable of regulating http://purl.obolibrary.org/obo/RO_0002500 causal agent in process Holds between c and p if and only if c is capable of some activity a, and a regulates p. http://purl.obolibrary.org/obo/RO_0002597 capable of negatively regulating http://purl.obolibrary.org/obo/RO_0002596 capable of regulating Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p. http://purl.obolibrary.org/obo/RO_0002598 capable of positively regulating http://purl.obolibrary.org/obo/RO_0002596 capable of regulating Holds between c and p if and only if c is capable of some activity a, and a positively regulates p. http://purl.obolibrary.org/obo/RO_0002608 process has causal agent http://purl.obolibrary.org/obo/RO_0002410 causally related to Inverse of 'causal agent in process' http://purl.obolibrary.org/obo/RO_0002015 has positive regulatory component activity http://purl.obolibrary.org/obo/RO_0002013 has regulatory component activity A relationship that holds between a GO molecular function and a component of that molecular function that positively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is positively regulated by B. http://purl.obolibrary.org/obo/RO_0002013 has regulatory component activity http://purl.obolibrary.org/obo/RO_0002017 has component activity A 'has regulatory component activity' B if A and B are GO molecular functions (GO_0003674), A has_component B and A is regulated by B. http://purl.obolibrary.org/obo/RO_0002014 has negative regulatory component activity http://purl.obolibrary.org/obo/RO_0002013 has regulatory component activity A relationship that holds between a GO molecular function and a component of that molecular function that negatively regulates the activity of the whole. More formally, A 'has regulatory component activity' B iff :A and B are GO molecular functions (GO_0003674), A has_component B and A is negatively regulated by B. http://purl.obolibrary.org/obo/RO_0013008 receives synaptic input from neuron http://purl.obolibrary.org/obo/RO_0002103 synapsed by A relationship between an anatomical structure (including cells) and a neuron that has a functionally relevant number of chemical synapses to it. http://purl.obolibrary.org/obo/RO_0020326 provides clinical information for http://purl.obolibrary.org/obo/RO_0002607 is marker for A relationship between a biomarker 'b' and a disease or condition of clinical interest 'd', where the presence or occurrence of 'b' provides clinical information about 'd'. http://purl.obolibrary.org/obo/RO_0020327 diagnostic for http://purl.obolibrary.org/obo/RO_0020326 provides clinical information for A relationship between a biomarker 'b' and a disease or condition of clinical interest 'd', where the presence or occurrence of 'b' is used to infer the presence or occurrence of 'd' or determine its subtype. http://purl.obolibrary.org/obo/RO_0020328 monitors status of http://purl.obolibrary.org/obo/RO_0020326 provides clinical information for A relationship between a serially-measured biomarker 'b' and a disease or condition of clinical interest 'd', where 'b' is used to infer the status of 'd'. http://purl.obolibrary.org/obo/RO_0020329 indicates response to http://purl.obolibrary.org/obo/RO_0020334 indicates clinical effect of A relationship between a biomarker 'b' and an exposure agent 'e', where 'b' is used to show that a biological response to 'e' has occurred. http://purl.obolibrary.org/obo/RO_0020334 indicates clinical effect of http://purl.obolibrary.org/obo/RO_0002607 is marker for A relationship between a biomarker 'b' and an exposure agent 'e', where the effect of exposure to 'e' is correlated with the presence or occurrence of 'b', and the observation of 'b' is used to infer exposure to 'e'. http://purl.obolibrary.org/obo/RO_0020330 predicts effect of http://purl.obolibrary.org/obo/RO_0020334 indicates clinical effect of A relationship between a biomarker 'b' and an exposure agent 'e', where 'b' is used to identify individuals who are likely to experience a favorable or unfavorable effect from exposure to 'e'. http://purl.obolibrary.org/obo/RO_0020331 prognostic for http://purl.obolibrary.org/obo/RO_0020326 provides clinical information for A relationship between a biomarker 'b' and a disease or condition of clinical interest 'd', where the presence or occurrence of 'b' is used to infer the likelihood of a clinical event, disease recurrence or progression in patients who have 'd'. http://purl.obolibrary.org/obo/RO_0020333 indicates risk of developing http://purl.obolibrary.org/obo/RO_0020326 provides clinical information for A relationship between a biomarker 'b' and a disease or condition of clinical interest 'd', where the presence or occurrence of 'b' is used to infer the potential for developing 'd' in an individual that currently does not have 'd'. http://purl.obolibrary.org/obo/RO_0020335 monitors effect of http://purl.obolibrary.org/obo/RO_0020334 indicates clinical effect of A relationship between a serially-measured biomarker 'b' and an exposure agent 'e', where 'b' is used to provide evidence of a biological effect of 'e'. http://purl.obolibrary.org/obo/RO_0020336 monitors exposure to http://purl.obolibrary.org/obo/RO_0020334 indicates clinical effect of A relationship between a serially-measured biomarker 'b' and an exposure agent 'e', where 'b' is used to provide evidence of exposure to 'e'. http://purl.obolibrary.org/obo/RO_0002082 simultaneous with http://purl.obolibrary.org/obo/RO_0002081 before or simultaneous with x simultaneous with y iff ω(x) = ω(y) and ω(α ) = ω(α), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point and '=' indicates the same instance in time. http://purl.obolibrary.org/obo/RO_0002102 axon synapses in http://purl.obolibrary.org/obo/RO_0002113 has presynaptic terminal in Relation between a neuron and some structure its axon forms (chemical) synapses in. http://purl.obolibrary.org/obo/RO_0002121 dendrite synapsed in http://purl.obolibrary.org/obo/RO_0002110 has postsynaptic terminal in Relation between a neuron and some structure (e.g.- a brain region) in which its dendrite receives synaptic input. http://purl.obolibrary.org/obo/RO_0002157 has derived by descendant http://purl.obolibrary.org/obo/RO_0002320 evolutionarily related to inverse of derived by descent from http://purl.obolibrary.org/obo/RO_0002158 shares ancestor with http://purl.obolibrary.org/obo/RO_0002320 evolutionarily related to two individual entities d1 and d2 stand in a shares_ancestor_with relation if and only if there exists some a such that d1 derived_by_descent_from a and d2 derived_by_descent_from a. http://purl.obolibrary.org/obo/RO_0002204 gene product of http://purl.obolibrary.org/obo/RO_0002330 genomically related to definition "x has gene product of y if and only if y is a gene (SO:0000704) that participates in some gene expression process (GO:0010467) where the output of that process is either y or something that is ribosomally translated from x" http://purl.obolibrary.org/obo/RO_0002205 has gene product http://purl.obolibrary.org/obo/RO_0002330 genomically related to x has gene product y if and only if x is a gene (SO:0000704) that participates in some gene expression process (GO:0010467) where the output of that process is either y or something that is ribosomally translated from y http://purl.obolibrary.org/obo/RO_0002206 expressed in http://purl.obolibrary.org/obo/RO_0002330 genomically related to x expressed in y if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and the transcription of x is part of the gene expression process (iii) x is a mature gene product such as a protein, and x was translated or otherwise processes from a transcript that was transcribed as part of this gene expression process http://purl.obolibrary.org/obo/RO_0002207 directly develops from http://purl.obolibrary.org/obo/RO_0002202 develops from Candidate definition: x directly_develops from y if and only if there exists some developmental process (GO:0032502) p such that x and y both participate in p, and x is the output of p and y is the input of p, and a substantial portion of the matter of x comes from y, and the start of x is coincident with or after the end of y. http://purl.obolibrary.org/obo/RO_0002221 surrounds http://purl.obolibrary.org/obo/RO_0002220 adjacent to inverse of surrounded by http://purl.obolibrary.org/obo/RO_0002225 develops from part of http://purl.obolibrary.org/obo/RO_0002202 develops from x develops from part of y if and only if there exists some z such that x develops from z and z is part of y http://purl.obolibrary.org/obo/RO_0002226 develops in http://purl.obolibrary.org/obo/RO_0002258 developmentally preceded by x develops_in y if x is located in y whilst x is developing http://purl.obolibrary.org/obo/RO_0002229 ends http://purl.obolibrary.org/obo/BFO_0000050 part of inverse of ends with http://purl.obolibrary.org/obo/RO_0002257 developmentally induces http://purl.obolibrary.org/obo/RO_0002386 has potential to developmentally induce Inverse of developmentally induced by http://purl.obolibrary.org/obo/RO_0002291 ubiquitously expressed in http://purl.obolibrary.org/obo/RO_0002206 expressed in x is ubiquitously expressed in y if and only if x is expressed in y, and the majority of cells in y express x http://purl.obolibrary.org/obo/RO_0002292 expresses http://purl.obolibrary.org/obo/RO_0002330 genomically related to y expresses x if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and x was transcribed from a gene as part of the gene expression process (iii) x is a mature gene product (protein or RNA), and x was translated or otherwise processed from a transcript that was transcribed as part of the gene expression process. http://purl.obolibrary.org/obo/RO_0002293 ubiquitously expresses http://purl.obolibrary.org/obo/RO_0002292 expresses inverse of ubiquiotously expressed in http://purl.obolibrary.org/obo/RO_0002295 results in developmental progression of http://purl.obolibrary.org/obo/RO_0002324 developmentally related to p results in the developmental progression of s iff p is a developmental process and s is an anatomical entity and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss). http://purl.obolibrary.org/obo/RO_0002296 results in development of http://purl.obolibrary.org/obo/RO_0002295 results in developmental progression of p 'results in development of' c if and only if p is a developmental process and p results in the state of c changing from its initial state as a primordium or anlage through its mature state and to its final state. http://purl.obolibrary.org/obo/RO_0002298 results in morphogenesis of http://purl.obolibrary.org/obo/RO_0002295 results in developmental progression of The relationship that links an entity with the process that results in the formation and shaping of that entity over time from an immature to a mature state. http://purl.obolibrary.org/obo/RO_0002299 results in maturation of http://purl.obolibrary.org/obo/RO_0002295 results in developmental progression of The relationship that links an entity with a process that results in the progression of the entity over time that is independent of changes in it's shape and results in an end point state of that entity. http://purl.obolibrary.org/obo/RO_0009501 realized in response to http://purl.obolibrary.org/obo/RO_0002410 causally related to r 'realized in response to' s iff, r is a realizable (e.g. a plant trait such as responsivity to drought), s is an environmental stimulus (a process), and s directly causes the realization of r. http://purl.obolibrary.org/obo/RO_0004026 disease has location http://purl.obolibrary.org/obo/RO_0040035 disease relationship A relationship between a disease and an anatomical entity where the disease has one or more features that are located in that entity. http://purl.obolibrary.org/obo/RO_0015003 subcluster of http://purl.obolibrary.org/obo/BFO_0000050 part of A relation between a group and another group it is part of but does not fully constitute. http://purl.obolibrary.org/obo/RO_0015015 has high plasma membrane amount http://purl.obolibrary.org/obo/RO_0002104 has plasma membrane part A relation between a cell and molecule or complex such that every instance of the cell has a high number of instances of that molecule expressed on the cell surface. http://purl.obolibrary.org/obo/RO_0015016 has low plasma membrane amount http://purl.obolibrary.org/obo/RO_0002104 has plasma membrane part A relation between a cell and molecule or complex such that every instance of the cell has a low number of instances of that molecule expressed on the cell surface. http://purl.obolibrary.org/obo/RO_0016004 has exposure medium http://purl.obolibrary.org/obo/RO_0002244 related via exposure to X has exposure medium Y if X is an exposure event (process), Y is a material entity, and the stimulus for X is transmitted or carried in Y. http://purl.obolibrary.org/obo/RO_0018001 is myristoyltransferase activity http://purl.obolibrary.org/obo/RO_0002564 molecular interaction relation helper property Helper relation for OWL definition of RO:0018002 myristoylates http://purl.obolibrary.org/obo/RO_0018002 myristoylates http://purl.obolibrary.org/obo/RO_0002436 molecularly interacts with A molecularly-interacts-with relationship between two entities, where the subject catalyzes a myristoylation activity that takes the object as input http://purl.obolibrary.org/obo/RO_0012009 constitutively upstream of http://purl.obolibrary.org/obo/RO_0002304 causally upstream of, positive effect p is constitutively upstream of q iff p is causally upstream of q, p is required for execution of q or a part of q, and the execution of p is approximately constant. http://purl.obolibrary.org/obo/RO_0012010 removes input for http://purl.obolibrary.org/obo/RO_0002305 causally upstream of, negative effect p removes input for q iff p is causally upstream of q, there exists some c such that p has_input c and q has_input c, p reduces the levels of c, and c is rate limiting for execution of q. http://purl.obolibrary.org/obo/RO_0012007 results in adhesion of http://purl.obolibrary.org/obo/RO_0040036 results in changes to anatomical or cellular structure The relationship that links anatomical entities with a process that results in the adhesion of two or more entities via the non-covalent interaction of molecules expressed in, located in, and/or adjacent to, those entities. http://purl.obolibrary.org/obo/RO_0013007 has sensory dendrite in http://purl.obolibrary.org/obo/RO_0002360 has dendrite location Relation between a sensory neuron and some structure in which it receives sensory input via a sensory dendrite. http://purl.obolibrary.org/obo/RO_0014001 disease has infectious agent http://purl.obolibrary.org/obo/RO_0004019 disease has basis in A relationship between a disease and an infectious agent where the material basis of the disease is an infection with some infectious agent. http://purl.obolibrary.org/obo/RO_0002238 has component participant http://purl.obolibrary.org/obo/RO_0000057 has participant X 'has component participant' Y means X 'has participant' Y and there is a cardinality constraint that specifies the numbers of Ys. http://purl.obolibrary.org/obo/RO_0002009 cell expresses http://purl.obolibrary.org/obo/RO_0002292 expresses A relation that applies between a cell(c) and a gene(g) , where the process of 'transcription, DNA templated (GO_0006351)' is occuring in in cell c and that process has input gene g. http://purl.obolibrary.org/obo/RO_0002010 regulates in another organism http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within x 'regulates in other organism' y if and only if: (x is the realization of a function to exert an effect on the frequency, rate or extent of y) AND (the agents of x are produced by organism o1 and the agents of y are produced by organism o2). http://purl.obolibrary.org/obo/RO_0002227 obligate parasite of http://purl.obolibrary.org/obo/RO_0002444 parasite of A sub-relation of parasite-of in which the parasite that cannot complete its life cycle without a host. http://purl.obolibrary.org/obo/RO_0002228 facultative parasite of http://purl.obolibrary.org/obo/RO_0002444 parasite of A sub-relations of parasite-of in which the parasite that can complete its life cycle independent of a host. http://purl.obolibrary.org/obo/RO_0002315 results in acquisition of features of http://purl.obolibrary.org/obo/RO_0002295 results in developmental progression of The relationship that links a specified entity with the process that results in an unspecified entity acquiring the features and characteristics of the specified entity http://purl.obolibrary.org/obo/RO_0002325 colocalizes with http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to a colocalizes_with b if and only if a is transiently or peripherally associated with b[GO]. http://purl.obolibrary.org/obo/RO_0002332 regulates levels of http://purl.obolibrary.org/obo/RO_0002328 functionally related to p regulates levels of c if p regulates some amount (PATO:0000070) of c http://purl.obolibrary.org/obo/RO_0002338 has target start location http://purl.obolibrary.org/obo/RO_0002344 results in transport to from or in This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from some initial location l to some destination. http://purl.obolibrary.org/obo/RO_0002339 has target end location http://purl.obolibrary.org/obo/RO_0002344 results in transport to from or in This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from a an initial location to some destination l. http://purl.obolibrary.org/obo/RO_0002340 imports http://purl.obolibrary.org/obo/RO_0002020 transports Holds between p and c when p is a transportation or localization process and the outcome of this process is to move c to a destination that is part of some s, where the start location of c is part of the region that surrounds s. http://purl.obolibrary.org/obo/RO_0002341 results in transport along http://purl.obolibrary.org/obo/RO_0002337 related via localization to Holds between p and l when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that is aligned_with l http://purl.obolibrary.org/obo/RO_0002342 results in transport across http://purl.obolibrary.org/obo/RO_0002344 results in transport to from or in Holds between p and m when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that crosses m. http://purl.obolibrary.org/obo/RO_0002345 exports http://purl.obolibrary.org/obo/RO_0002020 transports Holds between p and c when p is a transportation or localization process and the outcome of this process is to move c to a destination that is part of some s, where the end location of c is part of the region that surrounds s. http://purl.obolibrary.org/obo/RO_0002348 results in commitment to http://purl.obolibrary.org/obo/RO_0002295 results in developmental progression of p 'results in commitment to' c if and only if p is a developmental process and c is a cell and p results in the state of c changing such that is can only develop into a single cell type. http://purl.obolibrary.org/obo/RO_0002349 results in determination of http://purl.obolibrary.org/obo/RO_0002295 results in developmental progression of p 'results in determination of' c if and only if p is a developmental process and c is a cell and p results in the state of c changing to be determined. Once a cell becomes determined, it becomes committed to differentiate down a particular pathway regardless of its environment. http://purl.obolibrary.org/obo/RO_0002355 results in structural organization of http://purl.obolibrary.org/obo/RO_0002295 results in developmental progression of A relationship between a process and an anatomical entity such that the process contributes to the act of creating the structural organization of the anatomical entity. http://purl.obolibrary.org/obo/RO_0002356 results in specification of http://purl.obolibrary.org/obo/RO_0002295 results in developmental progression of The relationship linking a cell and its participation in a process that results in the fate of the cell being specified. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. http://purl.obolibrary.org/obo/RO_0002357 results in developmental induction of http://purl.obolibrary.org/obo/RO_0002295 results in developmental progression of p results in developmental induction of c if and only if p is a collection of cell-cell signaling processes that signal to a neighbouring tissue that is the precursor of the mature c, where the signaling results in the commitment to cell types necessary for the formation of c. http://purl.obolibrary.org/obo/RO_0002381 main stem of http://purl.obolibrary.org/obo/RO_0002375 in branching relationship with x main_stem_of y if y is a branching structure and x is a channel that traces a linear path through y, such that x has higher capacity than any other such path. http://purl.obolibrary.org/obo/RO_0002382 proper distributary of http://purl.obolibrary.org/obo/RO_0002377 distributary of x proper_distributary_of y iff x distributary_of y and x does not flow back into y http://purl.obolibrary.org/obo/RO_0002383 proper tributary of http://purl.obolibrary.org/obo/RO_0002376 tributary of x proper_tributary_of y iff x tributary_of y and x does not originate from y http://purl.obolibrary.org/obo/RO_0002386 has potential to developmentally induce http://purl.obolibrary.org/obo/RO_0002384 has developmental potential involving x has potential to developmentally induce y iff x developmentally induces y or x is capable of developmentally inducing y http://purl.obolibrary.org/obo/RO_0002414 transitively provides input for http://purl.obolibrary.org/obo/RO_0004047 causally upstream of or within, positive effect transitive form of directly_provides_input_for http://purl.obolibrary.org/obo/RO_0002428 involved in regulation of http://purl.obolibrary.org/obo/RO_0002431 involved in or involved in regulation of c involved in regulation of p if c is involved in some p' and p' regulates some p http://purl.obolibrary.org/obo/RO_0002429 involved in positive regulation of http://purl.obolibrary.org/obo/RO_0002428 involved in regulation of c involved in regulation of p if c is involved in some p' and p' positively regulates some p http://purl.obolibrary.org/obo/RO_0002430 involved in negative regulation of http://purl.obolibrary.org/obo/RO_0002428 involved in regulation of c involved in regulation of p if c is involved in some p' and p' negatively regulates some p http://purl.obolibrary.org/obo/RO_0002440 symbiotically interacts with http://purl.obolibrary.org/obo/RO_0002574 participates in a biotic-biotic interaction with A biotic interaction in which the two organisms live together in more or less intimate association. http://purl.obolibrary.org/obo/RO_0002441 commensually interacts with http://purl.obolibrary.org/obo/RO_0002440 symbiotically interacts with An interaction relationship between two organisms living together in more or less intimate association in a relationship in which one benefits and the other is unaffected (GO). http://purl.obolibrary.org/obo/RO_0002442 mutualistically interacts with http://purl.obolibrary.org/obo/RO_0002440 symbiotically interacts with An interaction relationship between two organisms living together in more or less intimate association in a relationship in which both organisms benefit from each other (GO). http://purl.obolibrary.org/obo/RO_0002443 interacts with via parasite-host interaction http://purl.obolibrary.org/obo/RO_0002440 symbiotically interacts with An interaction relationship between two organisms living together in more or less intimate association in a relationship in which association is disadvantageous or destructive to one of the organisms (GO). http://purl.obolibrary.org/obo/RO_0002446 participates in a abiotic-biotic interaction with http://purl.obolibrary.org/obo/RO_0002437 biotically interacts with A biotic interaction relationship in which one partner is an organism and the other partner is inorganic. For example, the relationship between a sponge and the substrate to which is it anchored. http://purl.obolibrary.org/obo/RO_0002452 has symptom http://purl.obolibrary.org/obo/RO_0002200 has phenotype A relation that holds between a disease or an organism and a phenotype http://purl.obolibrary.org/obo/RO_0002454 has host http://purl.obolibrary.org/obo/RO_0002440 symbiotically interacts with X 'has host' y if and only if: x is an organism, y is an organism, and x can live on the surface of or within the body of y http://purl.obolibrary.org/obo/RO_0002472 is evidence for http://purl.obolibrary.org/obo/RO_0002616 related via evidence or inference to A relationship between a piece of evidence a and some entity b, where b is an information content entity, material entity or process, and the a supports either the existence of b, or the truth value of b. http://purl.obolibrary.org/obo/RO_0002480 ubiquitinates http://purl.obolibrary.org/obo/RO_0002436 molecularly interacts with An interaction relation between x and y in which x catalyzes a reaction in which one or more ubiquitin groups are added to y http://purl.obolibrary.org/obo/RO_0002508 determines http://purl.obolibrary.org/obo/RO_0002566 causally influences inverse of determined by http://purl.obolibrary.org/obo/RO_0002509 determined by part of http://purl.obolibrary.org/obo/RO_0002131 overlaps s 'determined by part of' w if and only if there exists some f such that (1) s 'determined by' f and (2) f part_of w, or f=w. http://purl.obolibrary.org/obo/RO_0002510 transcribed from http://purl.obolibrary.org/obo/RO_0002330 genomically related to x is transcribed from y if and only if x is synthesized from template y http://purl.obolibrary.org/obo/RO_0002511 transcribed to http://purl.obolibrary.org/obo/RO_0002330 genomically related to inverse of transcribed from http://purl.obolibrary.org/obo/RO_0002512 ribosomal translation of http://purl.obolibrary.org/obo/RO_0002330 genomically related to x is the ribosomal translation of y if and only if a ribosome reads x through a series of triplet codon-amino acid adaptor activities (GO:0030533) and produces y http://purl.obolibrary.org/obo/RO_0002513 ribosomally translates to http://purl.obolibrary.org/obo/RO_0002330 genomically related to inverse of ribosomal translation of http://purl.obolibrary.org/obo/RO_0002515 sequentially adjacent to http://purl.obolibrary.org/obo/RO_0002527 does not overlap sequence of x is sequentially adjacent to y iff x and y do not overlap and if there are no base units intervening between x and y http://purl.obolibrary.org/obo/RO_0002520 is consecutive sequence of http://purl.obolibrary.org/obo/RO_0002524 has subsequence x is a consecutive sequence of y iff x has subsequence y, and all the parts of x are made of zero or more repetitions of y or sequences as the same type as y. http://purl.obolibrary.org/obo/RO_0002521 is sequentially aligned with http://purl.obolibrary.org/obo/RO_0002514 sequentially related to x is sequentially aligned with if a significant portion bases of x and y correspond in terms of their base type and their relative ordering http://purl.obolibrary.org/obo/RO_0002522 bounds sequence of http://purl.obolibrary.org/obo/RO_0002514 sequentially related to x bounds the sequence of y iff the upstream-most part of x is upstream of or coincident with the upstream-most part of y, and the downstream-most part of x is downstream of or coincident with the downstream-most part of y http://purl.obolibrary.org/obo/RO_0002523 is bound by sequence of http://purl.obolibrary.org/obo/RO_0002514 sequentially related to inverse of bounds sequence of http://purl.obolibrary.org/obo/RO_0002526 overlaps sequence of http://purl.obolibrary.org/obo/RO_0002514 sequentially related to x overlaps the sequence of y if and only if x has a subsequence z and z is a subsequence of y. http://purl.obolibrary.org/obo/RO_0002528 is upstream of sequence of http://purl.obolibrary.org/obo/RO_0002527 does not overlap sequence of inverse of downstream of sequence of http://purl.obolibrary.org/obo/RO_0002529 is downstream of sequence of http://purl.obolibrary.org/obo/RO_0002527 does not overlap sequence of x is downstream of the sequence of y iff either (1) x and y have sequence units, and all units of x are downstream of all units of y, or (2) x and y are sequence units, and x is either immediately downstream of y, or transitively downstream of y. http://purl.obolibrary.org/obo/RO_0002530 is immediately downstream of sequence of http://purl.obolibrary.org/obo/RO_0002529 is downstream of sequence of x is immediately downstream of the sequence of y iff either (1) x and y have sequence units, and all units of x are downstream of all units of y, and x is sequentially adjacent to y, or (2) x and y are sequence units, in which case the immediately downstream relation is primitive and defined by context: for DNA bases, y would be adjacent and 5' to y http://purl.obolibrary.org/obo/RO_0002531 is immediately upstream of sequence of http://purl.obolibrary.org/obo/RO_0002528 is upstream of sequence of inverse of immediately downstream of http://purl.obolibrary.org/obo/RO_0002552 results in ending of http://purl.obolibrary.org/obo/RO_0002295 results in developmental progression of p results in the end of s if p results in a change of state in s whereby s either ceases to exist, or s becomes functionally impaired or s has its fate committed such that it is put on a path to be degraded. http://purl.obolibrary.org/obo/RO_0002553 hyperparasite of http://purl.obolibrary.org/obo/RO_0002454 has host x is a hyperparasite of y iff x is a parasite of a parasite of the target organism y http://purl.obolibrary.org/obo/RO_0002554 hyperparasitized by http://purl.obolibrary.org/obo/RO_0002453 host of inverse of hyperparasite of http://purl.obolibrary.org/obo/RO_0002555 allelopath of http://purl.obolibrary.org/obo/RO_0002574 participates in a biotic-biotic interaction with A relationship between organisms where one organism is influenced by the biochemicals produced by another. http://purl.obolibrary.org/obo/RO_0002556 pathogen of http://purl.obolibrary.org/obo/RO_0002454 has host Inverse of has pathogen http://purl.obolibrary.org/obo/RO_0002557 has pathogen http://purl.obolibrary.org/obo/RO_0002453 host of A host interaction where the smaller of the two members of a symbiosis causes a disease in the larger member http://purl.obolibrary.org/obo/RO_0002558 has evidence http://purl.obolibrary.org/obo/RO_0002616 related via evidence or inference to inverse of is evidence for http://purl.obolibrary.org/obo/RO_0002565 results in movement of http://purl.obolibrary.org/obo/RO_0040036 results in changes to anatomical or cellular structure Holds between p and c when p is locomotion process and the outcome of this process is the change of location of c http://purl.obolibrary.org/obo/RO_0002570 conduit for http://purl.obolibrary.org/obo/RO_0002131 overlaps x is a conduit for y iff y overlaps through the lumen_of of x, and y has parts on either side of the lumen of x. http://purl.obolibrary.org/obo/RO_0002578 directly regulates http://purl.obolibrary.org/obo/RO_0002211 regulates p directly regulates q iff p is immediately causally upstream of q and p regulates q. http://purl.obolibrary.org/obo/RO_0002583 existence starts at end of http://purl.obolibrary.org/obo/RO_0002496 existence starts during or after holds between x and y if and only if the time point at which x starts is equivalent to the time point at which y ends. Formally: iff α(x) = ω(y). http://purl.obolibrary.org/obo/RO_0002586 results in breakdown of http://purl.obolibrary.org/obo/RO_0002233 has input p results in breakdown of c if and only if the execution of p leads to c no longer being present at the end of p http://purl.obolibrary.org/obo/RO_0002589 results in catabolism of http://purl.obolibrary.org/obo/RO_0002586 results in breakdown of p results in catabolism of c if and only if p is a catabolic process, and the execution of p results in c being broken into smaller parts with energy being released. http://purl.obolibrary.org/obo/RO_0002592 results in organization of http://purl.obolibrary.org/obo/RO_0040036 results in changes to anatomical or cellular structure p results in organization of c iff p results in the assembly, arrangement of constituent parts, or disassembly of c http://purl.obolibrary.org/obo/RO_0002593 existence ends at start of http://purl.obolibrary.org/obo/RO_0002497 existence ends during or before holds between x and y if and only if the time point at which x ends is equivalent to the time point at which y starts. Formally: iff ω(x) = α(y). http://purl.obolibrary.org/obo/RO_0002607 is marker for http://purl.obolibrary.org/obo/RO_0002610 correlated with c is marker for d iff the presence or occurrence of d is correlated with the presence of occurrence of c, and the observation of c is used to infer the presence or occurrence of d. Note that this does not imply that c and d are in a direct causal relationship, as it may be the case that there is a third entity e that stands in a direct causal relationship with c and d. http://purl.obolibrary.org/obo/RO_0002614 is evidence with support from http://purl.obolibrary.org/obo/RO_0002616 related via evidence or inference to A relationship between a piece of evidence and an entity that plays a role in supporting that evidence. http://purl.obolibrary.org/obo/RO_0002629 directly positively regulates http://purl.obolibrary.org/obo/RO_0002578 directly regulates p directly positively regulates q iff p is immediately causally upstream of q, and p positively regulates q. http://purl.obolibrary.org/obo/RO_0002630 directly negatively regulates http://purl.obolibrary.org/obo/RO_0002578 directly regulates p directly negatively regulates q iff p is immediately causally upstream of q, and p negatively regulates q. http://purl.obolibrary.org/obo/RO_0002632 ectoparasite of http://purl.obolibrary.org/obo/RO_0002444 parasite of A sub-relation of parasite-of in which the parasite lives on or in the integumental system of the host http://purl.obolibrary.org/obo/RO_0002633 has ectoparasite http://purl.obolibrary.org/obo/RO_0002445 parasitized by inverse of ectoparasite of http://purl.obolibrary.org/obo/RO_0002636 mesoparasite of http://purl.obolibrary.org/obo/RO_0002444 parasite of A sub-relation of parasite-of in which the parasite is partially an endoparasite and partially an ectoparasite http://purl.obolibrary.org/obo/RO_0002637 has mesoparasite http://purl.obolibrary.org/obo/RO_0002445 parasitized by inverse of mesoparasite of http://purl.obolibrary.org/obo/RO_0002638 intercellular endoparasite of http://purl.obolibrary.org/obo/RO_0002634 endoparasite of A sub-relation of endoparasite-of in which the parasite inhabits the spaces between host cells. http://purl.obolibrary.org/obo/RO_0002639 has intercellular endoparasite http://purl.obolibrary.org/obo/RO_0002635 has endoparasite inverse of intercellular endoparasite of http://purl.obolibrary.org/obo/RO_0002640 intracellular endoparasite of http://purl.obolibrary.org/obo/RO_0002634 endoparasite of A sub-relation of endoparasite-of in which the parasite inhabits host cells. http://purl.obolibrary.org/obo/RO_0002641 has intracellular endoparasite http://purl.obolibrary.org/obo/RO_0002635 has endoparasite inverse of intracellular endoparasite of http://purl.obolibrary.org/obo/RO_0003002 represses expression of http://purl.obolibrary.org/obo/RO_0002449 directly negatively regulates activity of Holds between entity A (a transcription factor) and a nucleic acid B if and only if A down-regulates the expression of B. The nucleic acid can be a gene or an mRNA. http://purl.obolibrary.org/obo/RO_0003003 increases expression of http://purl.obolibrary.org/obo/RO_0002450 directly positively regulates activity of Holds between entity A (a transcription factor) and nucleic acid B if and only if A up-regulates the expression of B. The nucleic acid can be a gene or mRNA. http://purl.obolibrary.org/obo/RO_0002081 before or simultaneous with http://purl.obolibrary.org/obo/RO_0002222 temporally related to <= http://purl.obolibrary.org/obo/RO_0002322 confers advantage in http://purl.obolibrary.org/obo/RO_0002321 ecologically related to adapted for http://purl.obolibrary.org/obo/RO_0002087 immediately preceded by http://purl.obolibrary.org/obo/BFO_0000062 preceded by starts_at_end_of http://purl.obolibrary.org/obo/RO_0002090 immediately precedes http://purl.obolibrary.org/obo/BFO_0000063 precedes meets http://purl.obolibrary.org/obo/RO_0002091 starts during http://purl.obolibrary.org/obo/RO_0002222 temporally related to io http://purl.obolibrary.org/obo/RO_0002092 happens during http://purl.obolibrary.org/obo/RO_0002093 ends during during http://purl.obolibrary.org/obo/RO_0002093 ends during http://purl.obolibrary.org/obo/RO_0002222 temporally related to overlaps http://purl.obolibrary.org/obo/RO_0002085 encompasses http://purl.obolibrary.org/obo/RO_0002088 during which starts di http://purl.obolibrary.org/obo/RO_0002447 phosphorylates http://purl.obolibrary.org/obo/RO_0002436 molecularly interacts with An interaction relation between x and y in which x catalyzes a reaction in which a phosphate group is added to y. http://purl.obolibrary.org/obo/RO_0002455 pollinates http://purl.obolibrary.org/obo/RO_0002442 mutualistically interacts with is subject of pollination interaction with http://purl.obolibrary.org/obo/RO_0002456 pollinated by http://purl.obolibrary.org/obo/RO_0002442 mutualistically interacts with is target of pollination interaction with http://purl.obolibrary.org/obo/RO_0002083 before http://purl.obolibrary.org/obo/RO_0002081 before or simultaneous with http://purl.obolibrary.org/obo/RO_0002343 results in growth of http://purl.obolibrary.org/obo/RO_0002295 results in developmental progression of http://purl.obolibrary.org/obo/RO_0002585 results in closure of http://purl.obolibrary.org/obo/RO_0002295 results in developmental progression of http://purl.obolibrary.org/obo/RO_0002297 results in formation of anatomical entity http://purl.obolibrary.org/obo/RO_0002295 results in developmental progression of http://purl.obolibrary.org/obo/RO_0002287 part of developmental precursor of http://purl.obolibrary.org/obo/RO_0002286 developmentally succeeded by http://purl.obolibrary.org/obo/RO_0002159 serially homologous to http://purl.obolibrary.org/obo/RO_0002320 evolutionarily related to http://purl.obolibrary.org/obo/RO_0002312 evolutionary variant of http://purl.obolibrary.org/obo/RO_0002320 evolutionarily related to http://purl.obolibrary.org/obo/RO_0002461 partner in http://purl.obolibrary.org/obo/RO_0000056 participates in http://purl.obolibrary.org/obo/RO_0002405 immediately causally downstream of http://purl.obolibrary.org/obo/RO_0002404 causally downstream of http://purl.obolibrary.org/obo/RO_0002017 has component activity http://purl.obolibrary.org/obo/RO_0002018 has component process http://purl.obolibrary.org/obo/RO_0002435 genetically interacts with http://purl.obolibrary.org/obo/RO_0002434 interacts with http://purl.obolibrary.org/obo/RO_0002559 causally influenced by http://purl.obolibrary.org/obo/RO_0002506 causal relation between entities http://purl.obolibrary.org/obo/RO_0002425 differs in attribute of http://purl.obolibrary.org/obo/RO_0002424 differs in http://purl.obolibrary.org/obo/RO_0002426 differs in attribute http://purl.obolibrary.org/obo/RO_0002424 differs in http://purl.obolibrary.org/obo/RO_0002563 interaction relation helper property http://purl.obolibrary.org/obo/RO_0002464 helper property (not for use in curation) http://purl.obolibrary.org/obo/RO_0002564 molecular interaction relation helper property http://purl.obolibrary.org/obo/RO_0002563 interaction relation helper property http://purl.obolibrary.org/obo/RO_0002465 is symbiosis http://purl.obolibrary.org/obo/RO_0002563 interaction relation helper property http://purl.obolibrary.org/obo/RO_0002481 is kinase activity http://purl.obolibrary.org/obo/RO_0002564 molecular interaction relation helper property http://purl.obolibrary.org/obo/RO_0002482 is ubiquitination http://purl.obolibrary.org/obo/RO_0002564 molecular interaction relation helper property http://purl.obolibrary.org/obo/RO_0002006 has synaptic terminal of http://purl.obolibrary.org/obo/RO_0002131 overlaps http://purl.obolibrary.org/obo/RO_0002360 has dendrite location http://purl.obolibrary.org/obo/RO_0002131 overlaps http://purl.obolibrary.org/obo/RO_0002089 starts before http://purl.obolibrary.org/obo/RO_0002222 temporally related to http://purl.obolibrary.org/obo/RO_0002086 ends after http://purl.obolibrary.org/obo/RO_0002222 temporally related to http://purl.obolibrary.org/obo/RO_0002084 during which ends http://purl.obolibrary.org/obo/RO_0002222 temporally related to http://purl.obolibrary.org/obo/RO_0002088 during which starts http://purl.obolibrary.org/obo/RO_0002222 temporally related to http://purl.obolibrary.org/obo/RO_0002591 results in remodeling of http://purl.obolibrary.org/obo/RO_0002592 results in organization of http://purl.obolibrary.org/obo/RO_0002354 formed as result of http://purl.obolibrary.org/obo/RO_0002353 output of http://purl.obolibrary.org/obo/RO_0002485 receives input from http://purl.obolibrary.org/obo/RO_0002170 connected to http://purl.obolibrary.org/obo/RO_0002486 sends output to http://purl.obolibrary.org/obo/RO_0002170 connected to http://purl.obolibrary.org/obo/RO_0004033 acts upstream of or within, negative effect http://purl.obolibrary.org/obo/RO_0002264 acts upstream of or within http://purl.obolibrary.org/obo/RO_0004032 acts upstream of or within, positive effect http://purl.obolibrary.org/obo/RO_0002264 acts upstream of or within http://purl.obolibrary.org/obo/RO_0002574 participates in a biotic-biotic interaction with http://purl.obolibrary.org/obo/RO_0002437 biotically interacts with http://purl.obolibrary.org/obo/RO_0002459 is vector for http://purl.obolibrary.org/obo/RO_0002574 participates in a biotic-biotic interaction with http://purl.obolibrary.org/obo/RO_0002460 has vector http://purl.obolibrary.org/obo/RO_0002574 participates in a biotic-biotic interaction with http://purl.obolibrary.org/obo/RO_0002618 visits http://purl.obolibrary.org/obo/RO_0002574 participates in a biotic-biotic interaction with http://purl.obolibrary.org/obo/RO_0002619 visited by http://purl.obolibrary.org/obo/RO_0002574 participates in a biotic-biotic interaction with http://purl.obolibrary.org/obo/RO_0002626 kills http://purl.obolibrary.org/obo/RO_0002574 participates in a biotic-biotic interaction with http://purl.obolibrary.org/obo/RO_0002627 is killed by http://purl.obolibrary.org/obo/RO_0002574 participates in a biotic-biotic interaction with http://purl.obolibrary.org/obo/RO_0004001 has material basis in gain of function germline mutation in http://purl.obolibrary.org/obo/RO_0004000 condition has genetic basis in http://purl.obolibrary.org/obo/RO_0004002 has material basis in loss of function germline mutation in http://purl.obolibrary.org/obo/RO_0004000 condition has genetic basis in http://purl.obolibrary.org/obo/RO_0004003 has material basis in germline mutation in http://purl.obolibrary.org/obo/RO_0004000 condition has genetic basis in http://purl.obolibrary.org/obo/RO_0004004 has material basis in somatic mutation in http://purl.obolibrary.org/obo/RO_0004000 condition has genetic basis in http://purl.obolibrary.org/obo/RO_0004005 has major susceptibility factor http://purl.obolibrary.org/obo/RO_0004000 condition has genetic basis in http://purl.obolibrary.org/obo/RO_0004006 has partial material basis in germline mutation in http://purl.obolibrary.org/obo/RO_0004000 condition has genetic basis in http://purl.obolibrary.org/obo/RO_0004019 disease has basis in http://purl.obolibrary.org/obo/RO_0004023 causal relationship with disease as subject http://purl.obolibrary.org/obo/RO_0004010 is genetic basis for condition http://purl.obolibrary.org/obo/RO_0004018 is basis for realizable http://purl.obolibrary.org/obo/RO_0004025 disease causes dysfunction of http://purl.obolibrary.org/obo/RO_0004023 causal relationship with disease as subject http://purl.obolibrary.org/obo/RO_0002326 contributes to http://purl.obolibrary.org/obo/RO_0002329 part of structure that is capable of http://purl.obolibrary.org/obo/RO_0002022 directly regulated by http://purl.obolibrary.org/obo/RO_0002334 regulated by http://purl.obolibrary.org/obo/RO_0002016 has necessary component activity http://purl.obolibrary.org/obo/RO_0002017 has component activity http://purl.obolibrary.org/obo/RO_0002506 causal relation between entities http://purl.obolibrary.org/obo/RO_0002410 causally related to http://purl.obolibrary.org/obo/RO_0004000 condition has genetic basis in http://purl.obolibrary.org/obo/RO_0002410 causally related to http://purl.obolibrary.org/obo/RO_0004017 realizable has basis in http://purl.obolibrary.org/obo/RO_0002410 causally related to http://purl.obolibrary.org/obo/RO_0004018 is basis for realizable http://purl.obolibrary.org/obo/RO_0002410 causally related to http://purl.obolibrary.org/obo/RO_0004023 causal relationship with disease as subject http://purl.obolibrary.org/obo/RO_0040035 disease relationship http://purl.obolibrary.org/obo/RO_0004046 causally upstream of or within, negative effect http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within http://purl.obolibrary.org/obo/RO_0004047 causally upstream of or within, positive effect http://purl.obolibrary.org/obo/RO_0002418 causally upstream of or within http://purl.obolibrary.org/obo/RO_0002587 results in synthesis of http://purl.obolibrary.org/obo/RO_0002297 results in formation of anatomical entity http://purl.obolibrary.org/obo/RO_0002588 results in assembly of http://purl.obolibrary.org/obo/RO_0002592 results in organization of http://purl.obolibrary.org/obo/RO_0002344 results in transport to from or in http://purl.obolibrary.org/obo/RO_0002337 related via localization to http://purl.obolibrary.org/obo/RO_0002453 host of http://purl.obolibrary.org/obo/RO_0002440 symbiotically interacts with http://purl.obolibrary.org/obo/RO_0002624 lays eggs in http://purl.obolibrary.org/obo/RO_0002618 visits http://purl.obolibrary.org/obo/RO_0002634 endoparasite of http://purl.obolibrary.org/obo/RO_0002444 parasite of http://purl.obolibrary.org/obo/RO_0002625 has eggs laid in by http://purl.obolibrary.org/obo/RO_0002619 visited by http://purl.obolibrary.org/obo/RO_0002635 has endoparasite http://purl.obolibrary.org/obo/RO_0002445 parasitized by http://purl.obolibrary.org/obo/RO_0002462 subject participant in http://purl.obolibrary.org/obo/RO_0002461 partner in http://purl.obolibrary.org/obo/RO_0002463 target participant in http://purl.obolibrary.org/obo/RO_0002461 partner in http://purl.obolibrary.org/obo/RO_0002466 is commensalism http://purl.obolibrary.org/obo/RO_0002465 is symbiosis http://purl.obolibrary.org/obo/RO_0002467 is mutualism http://purl.obolibrary.org/obo/RO_0002465 is symbiosis http://purl.obolibrary.org/obo/RO_0002468 is parasitism http://purl.obolibrary.org/obo/RO_0002465 is symbiosis http://purl.obolibrary.org/obo/RO_0002300 results in disappearance of http://purl.obolibrary.org/obo/RO_0002552 results in ending of http://purl.obolibrary.org/obo/RO_0002301 results in developmental regression of http://purl.obolibrary.org/obo/RO_0002552 results in ending of http://purl.obolibrary.org/obo/RO_0002590 results in disassembly of http://purl.obolibrary.org/obo/RO_0002592 results in organization of http://purl.obolibrary.org/obo/RO_0012008 results in fusion of http://purl.obolibrary.org/obo/RO_0002592 results in organization of http://purl.obolibrary.org/obo/RO_0002622 visits flowers of http://purl.obolibrary.org/obo/RO_0002618 visits http://purl.obolibrary.org/obo/RO_0002623 has flowers visited by http://purl.obolibrary.org/obo/RO_0002619 visited by http://purl.obolibrary.org/obo/RO_0000053 has characteristic is bearer of Inverse of characteristic_of http://purl.obolibrary.org/obo/RO_0000056 participates in participates_in a relation between a continuant and a process, in which the continuant is somehow involved in the process http://purl.obolibrary.org/obo/RO_0000057 has participant has_participant a relation between a process and a continuant, in which the continuant is somehow involved in the process http://purl.obolibrary.org/obo/RO_0001000 derives from derives_from a relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity http://purl.obolibrary.org/obo/RO_0001001 derives into derives_into a relation between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity http://purl.obolibrary.org/obo/RO_0001015 location of location_of a relation between two independent continuants, the location and the target, in which the target is entirely within the location http://purl.obolibrary.org/obo/RO_0001025 located in located_in a relation between two independent continuants, the target and the location, in which the target is entirely within the location http://purl.obolibrary.org/obo/RO_0002218 obsolete has active participant has agent OBSOLETE x has participant y if and only if x realizes some active role that inheres in y http://purl.obolibrary.org/obo/RO_0003301 has role in modeling is used to study A relation between a biological, experimental, or computational artifact and an entity it is used to study, in virtue of its replicating or approximating features of the studied entity. http://purl.obolibrary.org/obo/RO_0002402 obsolete has direct output directly produces p has direct input c iff c is a participanti n p, c is present at the end of p, and c is not present at the beginning of c. http://purl.obolibrary.org/obo/BFO_0000066 occurs in unfolds_in b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t http://purl.obolibrary.org/obo/RO_0002217 obsolete actively participates in agent in OBSOLETE x actively participates in y if and only if x participates in y and x realizes some active role http://purl.obolibrary.org/obo/RO_HOM0000000 in similarity relationship with Relation between biological objects that resemble or are related to each other sufficiently to warrant a comparison. http://purl.obolibrary.org/obo/RO_0009004 has consumer 'has consumer' is a relation between a material entity and an organism in which the former can normally be digested or otherwise absorbed by the latter without immediate or persistent ill effect. http://purl.obolibrary.org/obo/RO_0002320 evolutionarily related to A relationship that holds via some environmental process http://purl.obolibrary.org/obo/RO_0002324 developmentally related to A relationship that holds between entities participating in some developmental process (GO:0032502) http://purl.obolibrary.org/obo/RO_0015004 has characterizing marker set A relation that applies between a cell type and a set of markers that can be used to uniquely identify that cell type. http://purl.obolibrary.org/obo/BFO_0000055 realizes Paraphrase of elucidation: a relation between a process and a realizable entity, where there is some material entity that is bearer of the realizable entity and participates in the process, and the realizable entity comes to be realized in the course of the process http://purl.obolibrary.org/obo/BFO_0000067 contains process [copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t http://purl.obolibrary.org/obo/RO_0000058 is concretized as A relationship between a generically dependent continuant and a specifically dependent continuant or process, in which the generically dependent continuant depends on some independent continuant or process in virtue of the fact that the specifically dependent continuant or process also depends on that same independent continuant. A generically dependent continuant may be concretized as multiple specifically dependent continuants or processes. http://purl.obolibrary.org/obo/RO_0000059 concretizes A relationship between a specifically dependent continuant or process and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant or process also depends on that same independent continuant. Multiple specifically dependent continuants or processes can concretize the same generically dependent continuant. http://purl.obolibrary.org/obo/RO_0009001 has substance added "has substance added" is a relation existing between a (physical) entity and a substance in which the entity has had the substance added to it at some point in time. http://purl.obolibrary.org/obo/RO_0007000 has driver A relation between two entities, in which one of the entities is any natural or human-influenced factor that directly or indirectly causes a change in the other entity. http://purl.obolibrary.org/obo/RO_0017001 device utilizes material X device utilizes material Y means X and Y are material entities, and X is capable of some process P that has input Y. http://purl.obolibrary.org/obo/RO_0003000 produces a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix. http://purl.obolibrary.org/obo/RO_0003001 produced by a produced_by b iff some process that occurs_in b has_output a. http://purl.obolibrary.org/obo/RO_0015001 has exemplar data A relation between a material entity and some data in which the data is taken as exemplifying the material entity. http://purl.obolibrary.org/obo/RO_0019003 has substitutable entity Relates one individual to another which is capable of standing in for the first individual in its other relations to other individuals. http://purl.obolibrary.org/obo/RO_0002434 interacts with A relationship that holds between two entities in which the processes executed by the two entities are causally connected. http://purl.obolibrary.org/obo/RO_0002573 has modifier A relation that holds between an attribute or a qualifier and another attribute. http://purl.obolibrary.org/obo/RO_0009003 immersed in "immersed in" is a relation between a (physical) entity and a fluid substance in which the entity is wholely or substantially surrounded by the substance. http://purl.obolibrary.org/obo/RO_0002029 has increased age-specific mortality rate Then percentage of organisms in a population that die during some specified age range (age-specific mortality rate), minus the percentage that die in during the same age range in a wild-type population. http://purl.obolibrary.org/obo/RO_0015006 different in magnitude relative to q1 different_in_magnitude_relative_to q2 if and only if magnitude(q1) NOT =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. http://purl.obolibrary.org/obo/RO_0015009 similar in magnitude relative to q1 similar_in_magnitude_relative_to q2 if and only if magnitude(q1) =~ magnitude(q2). Here, magnitude(q) is a function that maps a quality to a unit-invariant scale. http://purl.obolibrary.org/obo/RO_0002323 mereotopologically related to A mereological relationship or a topological relationship http://purl.obolibrary.org/obo/RO_0002328 functionally related to A grouping relationship for any relationship directly involving a function, or that holds because of a function of one of the related entities. http://purl.obolibrary.org/obo/RO_0002214 has prototype x has prototype y if and only if x is an instance of C and y is a prototypical instance of C. For example, every instance of heart, both normal and abnormal is related by the has prototype relation to some instance of a "canonical" heart, which participates in blood circulation. http://purl.obolibrary.org/obo/RO_0015011 has cross section s3 has_cross_section s3 if and only if : there exists some 2d plane that intersects the bearer of s3, and the impression of s3 upon that plane has shape quality s2. http://purl.obolibrary.org/obo/RO_0015012 reciprocal of q1 reciprocal_of q2 if and only if : q1 and q2 are relational qualities and a phenotype e q1 e2 mutually implies a phenotype e2 q2 e. http://purl.obolibrary.org/obo/RO_0009006 assay measures characteristic A relation between an assay and a characteristic, in which the assay generates a data item which is a measure of a characteristic. http://purl.obolibrary.org/obo/RO_0009007 characteristic measured by assay Inverse of 'assay measures characteristic' http://purl.obolibrary.org/obo/RO_0017006 has maximum capacity A relation that relates a container to a measurement datum that specifies the maximum capacity of the container. Capacity can refer to either weight or volume. http://purl.obolibrary.org/obo/RO_0017008 owns A primitive relation that holds between entities x and y in which y is at x's full disposal. http://purl.obolibrary.org/obo/RO_0017009 is owned by Inverse of the owns relation. http://purl.obolibrary.org/obo/RO_0017502 collected during A relation between a material entity and an occurrent in which the material entity is collected during the existence of the occurrent. http://purl.obolibrary.org/obo/RO_0020104 is neuron This property only applies to neurons http://purl.obolibrary.org/obo/RO_0020105 is anatomical entity This property only applies to anatomical entities. http://purl.obolibrary.org/obo/RO_0002330 genomically related to holds between two entities when some genome-level process such as gene expression is involved. This includes transcriptional, spliceosomal events. These relations can be used between either macromolecule entities (such as regions of nucleic acid) or between their abstract informational counterparts. http://purl.obolibrary.org/obo/RO_0002321 ecologically related to A relationship that is mediated in some way by the environment or environmental feature (ENVO:00002297) http://purl.obolibrary.org/obo/RO_0009002 has substance removed "has substance removed" is a relation existing between two physical entities in which the first entity has had the second entity (a substance) removed from it at some point in time. http://purl.obolibrary.org/obo/RO_0017005 contains measured amount A relation between a container and measurement datum that specifies the actual amount of material in the container. http://purl.obolibrary.org/obo/RO_0017007 symptom of inverse of 'has symptom' http://purl.obolibrary.org/obo/RO_0017002 information specifies A relation between information and an entity such that the information serves as a rule or guide if the entity is an occurrent, or the information serves as a model if the entity is a continuant. http://purl.obolibrary.org/obo/RO_0017010 specified by information Inverse of information specifies. http://purl.obolibrary.org/obo/RO_0002134 innervates Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input. T innervates some R Expands_to: T has_fasciculating_neuron_projection that synapse_in some R. http://purl.obolibrary.org/obo/RO_0000300 obsolete in neural circuit with OBSOLETE A relation that holds between two neurons connected directly via a synapse, or indirectly via a series of synaptically connected neurons. http://purl.obolibrary.org/obo/RO_0000301 obsolete upstream in neural circuit with OBSOLETE A relation that holds between a neuron that is synapsed_to another neuron or a neuron that is connected indirectly to another by a chain of neurons, each synapsed_to the next, in which the direction is from the last to the first. http://purl.obolibrary.org/obo/RO_0000302 obsolete downstream in neural circuit with OBSOLETE A relation that holds between a neuron that is synapsed_by another neuron or a neuron that is connected indirectly to another by a chain of neurons, each synapsed_by the next, in which the direction is from the last to the first. http://purl.obolibrary.org/obo/RO_0002005 innervated by relation between an anatomical structure and a neuron projection bundle that has synaptic terminals in the structure. http://purl.obolibrary.org/obo/RO_0002410 causally related to relation that links two events, processes, states, or objects such that one event, process, state, or object (a cause) contributes to the production of another event, process, state, or object (an effect) where the cause is partly or wholly responsible for the effect, and the effect is partly or wholly dependent on the cause. http://purl.obolibrary.org/obo/RO_0002479 has part that occurs in p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c. http://purl.obolibrary.org/obo/RO_0002609 obsolete related via dependence to A relationship that holds between two entities, where the relationship holds based on the presence or absence of statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes. http://purl.obolibrary.org/obo/RO_0002201 phenotype of inverse of has phenotype http://purl.obolibrary.org/obo/RO_0018003 myristoylated by inverse of myristoylates http://purl.obolibrary.org/obo/RO_0002011 regulates transport of A relationship that holds between a process that regulates a transport process and the entity transported by that process. http://purl.obolibrary.org/obo/RO_0002337 related via localization to A relationship that holds via some process of localization http://purl.obolibrary.org/obo/RO_0002514 sequentially related to A relation that holds between two entities that have the property of being sequences or having sequences. http://purl.obolibrary.org/obo/RO_0002610 correlated with A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes. http://purl.obolibrary.org/obo/RO_0002615 has model Inverse of is-model-of http://purl.obolibrary.org/obo/RO_0010001 generically depends on A generically dependent continuant *b* generically depends on an independent continuant *c* at time *t* means: there inheres in *c* a specifically deendent continuant which concretizes *b* at *t*. http://purl.obolibrary.org/obo/RO_0010002 is carrier of *b* is carrier of *c* at time *t* if and only if *c* *g-depends on* *b* at *t* http://purl.obolibrary.org/obo/RO_0040035 disease relationship This relation groups relations between diseases and any other kind of entity. http://purl.obolibrary.org/obo/ENVO_01003004 derives from part of A relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist through the separation or transformation of a part of the old entity, and the new entity inherits a significant portion of the matter belonging to that part of the old entity. http://purl.obolibrary.org/obo/BFO_0000054 realized in realized_in http://purl.obolibrary.org/obo/RO_0001018 obsolete contained in contained_in http://purl.obolibrary.org/obo/RO_0002111 releases neurotransmitter has neurotransmitter http://purl.obolibrary.org/obo/BFO_0000060 obsolete preceded by http://purl.obolibrary.org/obo/RO_0004096 DEPRECATED inheres in http://purl.obolibrary.org/obo/RO_0004097 DEPRECATED bearer of http://purl.obolibrary.org/obo/RO_0016001 has phenotype or disease http://purl.obolibrary.org/obo/RO_0002408 obsolete directly inhibits http://purl.obolibrary.org/obo/RO_0002424 differs in http://purl.obolibrary.org/obo/RO_0002464 helper property (not for use in curation) http://purl.obolibrary.org/obo/RO_0002487 relation between physical entity and a process or stage http://purl.obolibrary.org/obo/RO_0002401 obsolete has indirect input http://purl.obolibrary.org/obo/CL_4030045 lacks_part http://purl.obolibrary.org/obo/RO_0002222 temporally related to http://purl.obolibrary.org/obo/CL_4030046 lacks_plasma_membrane_part http://purl.obolibrary.org/obo/RO_0018030 chemical relationship http://purl.obolibrary.org/obo/RO_0002502 depends on http://purl.obolibrary.org/obo/RO_0015010 has relative magnitude http://purl.obolibrary.org/obo/RO_0015002 exemplar data of http://purl.obolibrary.org/obo/RO_0001019 obsolete contains http://purl.obolibrary.org/obo/RO_0002001 aligned with http://purl.obolibrary.org/obo/RO_0002403 obsolete has indirect output http://purl.obolibrary.org/obo/RO_0002406 obsolete directly activates http://purl.obolibrary.org/obo/RO_0002616 related via evidence or inference to