Term IRI	Term label	Parent term IRI	Parent term label	Alternative term	Definition
http://purl.obolibrary.org/obo/IDOMAL_50000026	Mutation	http://purl.obolibrary.org/obo/SCDO_0001369	Genetic Variation		A permanent change in the DNA sequence of a gene that alters the genetic message carried by that gene.
http://purl.obolibrary.org/obo/SCDO_0000455	Global Mental Status Screener	http://purl.obolibrary.org/obo/NCIT_C91105	Clinical or Research Assessment Questionnaire		A test to assess the respondent's overall mental capability.
http://purl.obolibrary.org/obo/SCDO_0000045	Alpha-Adrenergic Agents	http://purl.obolibrary.org/obo/SCDO_0000067	Antihypertensive Agents		Drugs that selectively bind to and activate alpha adrenergic receptors.
http://purl.obolibrary.org/obo/CHEBI_35493	Antipyretic	http://purl.obolibrary.org/obo/CHEBI_23888	Drug		A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever.
http://purl.obolibrary.org/obo/CHEBI_50858	Corticosteroid	http://purl.obolibrary.org/obo/SCDO_0000057	Anti-Inflammatory Agent		A natural or synthetic analogue of the hormones secreted by the adrenal gland.
http://purl.obolibrary.org/obo/CHEBI_6807	Methadone	http://purl.obolibrary.org/obo/CHEBI_35482	Opioid		A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of morphine. It also has a depressant action on the cough center and may be given to control intractable cough associated with terminal lung cancer. Methadone is also used as part of the treatment of dependence on opioid drugs, although prolonged use of methadone itself may result in dependence.
http://purl.obolibrary.org/obo/HP_0025065	Abnormal Mean Corpuscular Volume	http://purl.obolibrary.org/obo/HP_0001877	Abnormal Erythrocyte Morphology		A deviation from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells, usually taken to be 80 to 100 femtoliters.
http://purl.obolibrary.org/obo/MP_0001212	Skin Lesions	http://purl.obolibrary.org/obo/HP_0011123	Skin Inflammation		Focal pathological and/or inflammatory changes characterized by alteration in the size, shape and organization of the cellular components of the skin.
http://purl.obolibrary.org/obo/MP_0001589	Abnormal Mean Corpuscular Hemoglobin	http://purl.obolibrary.org/obo/HP_0001877	Abnormal Erythrocyte Morphology		Anomalies in the average levels of hemoglobin contained in an erythrocyte.
http://purl.obolibrary.org/obo/MP_0001762	Diuresis	http://purl.obolibrary.org/obo/HP_0000079	Abnormality of the Urinary System		Increased volume of urine produced and excreted.
http://purl.obolibrary.org/obo/MP_0001792	Impaired Wound Healing	http://purl.obolibrary.org/obo/SCDO_0002674	Abnormality of Metabolism/Homeostasis		Reduced ability or inability to self-repair and close wounds.
http://purl.obolibrary.org/obo/MP_0002081	Perinatal Death	http://purl.obolibrary.org/obo/HP_0001197	Abnormality of Prenatal Development or Birth		Death anytime within the perinatal period.
http://purl.obolibrary.org/obo/MP_0002118	Abnormal Lipid Homeostasis	http://purl.obolibrary.org/obo/SCDO_0002674	Abnormality of Metabolism/Homeostasis		Anomaly in the processes involved in the maintenance of an internal equilibrium of lipids in the fluids and tissues.
http://purl.obolibrary.org/obo/MP_0002329	Abnormal Blood Gas Level	http://purl.obolibrary.org/obo/HP_0002086	Abnormality of the Respiratory System		Anomaly in the amount of oxygen and carbon dioxide in the blood.
http://purl.obolibrary.org/obo/MP_0002412	Increased Susceptibility to Bacterial Infection	http://purl.obolibrary.org/obo/HP_0002715	Abnormality of the Immune System		Greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria.
http://purl.obolibrary.org/obo/MP_0003224	Neuron Degeneration	http://purl.obolibrary.org/obo/HP_0012639	Abnormal Nervous System Morphology		A retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses.
http://purl.obolibrary.org/obo/MP_0005376	Metabolism/Homeostasis Phenotype	http://purl.obolibrary.org/obo/OGMS_0000023	Phenotype		The observable morphological and physiological characteristics related to a state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues or the processes that cause many of the chemical changes in living mammalian organisms that are manifested through development and lifespan.
http://purl.obolibrary.org/obo/MP_0009642	Abnormal Blood Homeostasis	http://purl.obolibrary.org/obo/SCDO_0002674	Abnormality of Metabolism/Homeostasis		Anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood.
http://purl.obolibrary.org/obo/MP_0010067	Increased Red Blood Cell Distribution Width	http://purl.obolibrary.org/obo/MP_0010066	Abnormal Red Blood Cell Distribution Width		Higher than normal coefficient of variance (reference range) of the red blood cell volume for an organism.
http://purl.obolibrary.org/obo/MP_0010163	Hemolysis	http://purl.obolibrary.org/obo/HP_0020054	Abnormal Erythrocyte Physiology		Destruction of erythrocytes such that hemoglobin is released from the cells; may occur by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
http://purl.obolibrary.org/obo/MP_0011468	Abnormal Urine Amino Acid Level	http://purl.obolibrary.org/obo/HP_0003110	Abnormal Urine Homeostasis		Any anomaly in the amount in the urine of a carboxylic acid containing one or more amino groups (-NH2) and a carboxyl (-COOH) group.
http://purl.obolibrary.org/obo/MP_0005533	Increased Body Temperature	http://purl.obolibrary.org/obo/MP_0005535	Abnormal Body Temperature		Greater than the level of heat natural to a living being.
http://purl.obolibrary.org/obo/MP_0005534	Decreased Body Temperature	http://purl.obolibrary.org/obo/MP_0005535	Abnormal Body Temperature		Less than the level of heat natural to a living being.
http://purl.obolibrary.org/obo/MP_0005535	Abnormal Body Temperature	http://purl.obolibrary.org/obo/SCDO_0002674	Abnormality of Metabolism/Homeostasis		Deviation in the level of heat natural to a living being.
http://purl.obolibrary.org/obo/MP_0005561	Increased Mean Corpuscular Hemoglobin	http://purl.obolibrary.org/obo/MP_0001589	Abnormal Mean Corpuscular Hemoglobin		Greater than the average levels of hemoglobin contained in an erythrocyte.
http://purl.obolibrary.org/obo/MP_0005562	Decreased Mean Corpuscular Hemoglobin	http://purl.obolibrary.org/obo/MP_0001589	Abnormal Mean Corpuscular Hemoglobin		Less than the average levels of hemoglobin contained in an erythrocyte.
http://purl.obolibrary.org/obo/MP_0009568	Abnormal Red Blood Cell Deformability	http://purl.obolibrary.org/obo/HP_0020054	Abnormal Erythrocyte Physiology		A measure (DImax) related to cell surface area, of the changeability of the membrane of circulating oxygen transporting cells as a function of physiologically relevant osmolality at a constant applied shear stress.
http://purl.obolibrary.org/obo/MP_0010066	Abnormal Red Blood Cell Distribution Width	http://purl.obolibrary.org/obo/HP_0001877	Abnormal Erythrocyte Morphology		An anomaly in the coefficient of variance (reference range) of the red blood cell volume for an organism.
http://purl.obolibrary.org/obo/MP_0010068	Decreased Red Blood Cell Distribution Width	http://purl.obolibrary.org/obo/MP_0010066	Abnormal Red Blood Cell Distribution Width		Lower than normal coefficient of variance (reference range) of the red blood cell volume for an organism.
http://purl.obolibrary.org/obo/UO_0000180	Mass Per Unit Volume	http://purl.obolibrary.org/obo/UO_0000051	Concentration Unit		A concentration unit which is a standard measure of the mass of a substance in a given volume (density).
http://purl.obolibrary.org/obo/UO_0000200	Cell Concentration Unit	http://purl.obolibrary.org/obo/UO_0000051	Concentration Unit		A concentration unit which denotes the average cell number in a given volume.
http://purl.obolibrary.org/obo/UO_0000272	mmHg	http://purl.obolibrary.org/obo/UO_0000109	Pressure Unit		A unit of pressure equal to the amount of fluid pressure one millimeter deep in mercury at zero degrees centigrade on Earth.
http://purl.obolibrary.org/obo/UO_0000316	cells per microliter	http://purl.obolibrary.org/obo/UO_0000200	Cell Concentration Unit		A unit of cell concentration which is equal to one cell in a volume of 1 microliter.
http://purl.obolibrary.org/obo/VO_0000642	Influenza Virus Vaccine	http://purl.obolibrary.org/obo/VO_0000001	Vaccine		A viral vaccine that protects against infection with influenza virus.
http://purl.obolibrary.org/obo/APOLLO_SV_00000241	Age Range Category	http://purl.obolibrary.org/obo/SCDO_0300005	Research Characteristics		An information content entity specifying the upper and lower limit of a range of ages of continuants.
http://purl.obolibrary.org/obo/OBI_0002140	Temperature Measurement Assay	http://purl.obolibrary.org/obo/SCDO_0000902	Physiological Assay		An assay to determine the temperature of an evaluant.
http://purl.obolibrary.org/obo/HP_0031956	Elevated Serum Aspartate Aminotransferase	http://purl.obolibrary.org/obo/HP_0012379	Abnormal Enzyme/Coenzyme Activity		An abnormally high concentration in the circulation of aspartate aminotransferase (AST).
http://purl.obolibrary.org/obo/HP_0031964	Elevated Serum Alanine Aminotransferase	http://purl.obolibrary.org/obo/HP_0012379	Abnormal Enzyme/Coenzyme Activity		An abnormally high concentration in the circulation of alanine aminotransferase (ALT), which is an enzyme that catalyzes the transfer of amino groups to form the hepatic metabolite oxaloacetate. ALT is found abundantly in the cytosol of the hepatocyte. ALT activity in the liver is about 3000 times that of serum activity. Thus, in the case of hepatocellular injury or death, release of ALT from damaged liver cells increases measured ALT activity in the serum. Although it is generally thought to be specific to the liver, it is also found in the kidney, and, in much smaller quantities, in heart and skeletal muscle cells.
http://purl.obolibrary.org/obo/ICO_0000228	Data Sharing	http://purl.obolibrary.org/obo/SCDO_0006339	Research		A planned process in which data possessed by one person or organization is shared with one or more other persons or organizations.
http://purl.obolibrary.org/obo/ICO_0000255	Participant Withdrawal Process	http://purl.obolibrary.org/obo/SCDO_1000422	Basic Element of a Consent Form		A directive information entity that prescribes some process for withdraw from another planned process.
http://purl.obolibrary.org/obo/ICO_0000278	Description of Future Biospecimen Use	http://purl.obolibrary.org/obo/ICO_0000305	Description of Future Use		A descriptive information content entity that describes how biospecimens will be used.
http://purl.obolibrary.org/obo/ICO_0000293	Data Sharing Agreement	http://purl.obolibrary.org/obo/SCDO_1000406	Data Sharing Descriptor		A directive information entity that prescribes the information that is permitted to be shared or the processes for sharing that information.
http://purl.obolibrary.org/obo/ICO_0000304	Description of Future Data Use	http://purl.obolibrary.org/obo/ICO_0000305	Description of Future Use		A descriptive information content entity that describes how data will be used.
http://purl.obolibrary.org/obo/ICO_0000305	Description of Future Use	http://purl.obolibrary.org/obo/SCDO_1000422	Basic Element of a Consent Form		A descriptive information content entity that describes future use of material or information.
http://purl.obolibrary.org/obo/GSSO_003239	Ethical Principle	http://purl.obolibrary.org/obo/SCDO_1000430	Ethics Related Concept		Principles which provide a framework within which ethical dilemmas and other problems may be analyzed.
http://purl.obolibrary.org/obo/SCDO_0000506	Hematopoietic Stem Cell Transplantation	http://purl.obolibrary.org/obo/SCDO_0000301	Curative Therapeutics		Transfer of hematopoietic stem cells from bone marrow or blood between individuals within the same species (transplantation, homologous) or transfer within the same individual (transplantation, autologous). Hematopoietic stem cell transplantation has been used as an alternative to bone marrow transplantation in the treatment of a variety of neoplasms.
http://purl.obolibrary.org/obo/SCDO_0000598	Hypnotics and Sedatives	http://purl.obolibrary.org/obo/CHEBI_23888	Drug		Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
http://purl.obolibrary.org/obo/SCDO_0001384	Reduced Alpha/Gamma Synthesis Ratio	http://purl.obolibrary.org/obo/HP_0005560	Imbalanced Hemoglobin Synthesis		A reduction in the ratio of production of alpha globin to that of gamma globin.
http://purl.obolibrary.org/obo/IDOMAL_0000122	Malaria Chemoprophylaxis	http://purl.obolibrary.org/obo/SCDO_0000709	Malaria Prophylaxis		The use of antimalarial drugs for the prevention of infection.
http://purl.obolibrary.org/obo/ExO_0000034	Occupation	http://purl.obolibrary.org/obo/SCDO_1000157	Quality of Life Related Personal Attribute		An individual attribute that is the usual or principal work or business of an individual.
http://purl.obolibrary.org/obo/NCIT_C101217	Retinal Examination	http://purl.obolibrary.org/obo/SCDO_0000835	Ophthalmoscopy		An examination of the retina of the eye using an ophthalmoscope.
http://purl.obolibrary.org/obo/NCIT_C102531	Pulmonary Infiltrate	http://purl.obolibrary.org/obo/HP_0002086	Abnormality of the Respiratory System		A finding indicating the presence of an inflammatory or neoplastic cellular infiltrate in the lung parenchyma.
http://purl.obolibrary.org/obo/NCIT_C16612	Gene	http://purl.obolibrary.org/obo/SCDO_0005722	Genetic Structure		A functional unit of heredity which occupies a specific position on a particular chromosome and serves as the template for a product that contributes to a phenotype or a biological function.
http://purl.obolibrary.org/obo/NCIT_C16632	Geographic Area	http://purl.obolibrary.org/obo/NCIT_C19332	Personal Attribute		Any demarcated area of the Earth; may be determined by both natural and human boundaries.
http://purl.obolibrary.org/obo/NCIT_C17241	Urine Test	http://purl.obolibrary.org/obo/SCDO_0000902	Physiological Assay		Laboratory analysis of urine, commonly used to aid in the diagnosis of disease or to detect the presence of a specific substance. It involves examination of the urine by physical or chemical means as well as microscopic examination that helps to screen for urinary tract infections, renal disease, and diseases of other organs, that result in abnormal metabolites (break-down products) appearing in the urine.
http://purl.obolibrary.org/obo/NCIT_C25464	deprecated Country	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		A collective generic term that refers here to a wide variety of dependencies, areas of special sovereignty, uninhabited islands, and other entities in addition to the traditional countries or independent states.
http://purl.obolibrary.org/obo/NCIT_C27222	Cerebral Aneurysm	http://purl.obolibrary.org/obo/HP_0002060	Abnormality of the Cerebrum		A balloon type pouch or bulge in the wall of a cerebral blood vessel.
http://purl.obolibrary.org/obo/NCIT_C3671	Injury	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
http://purl.obolibrary.org/obo/NCIT_C38060	Eye Examination	http://purl.obolibrary.org/obo/SCDO_0000898	Physical Examination		A test performed by an ophthalmologist or optometrist assessing vision and ability to focus on and discern objects, as well as other tests and examinations pertaining to the eyes.
http://purl.obolibrary.org/obo/NCIT_C43646	Association	http://purl.obolibrary.org/obo/SCDO_0001000	SCDO		An association is a non-hierarchical, named relationship between a source and target concept that does not affect classification and is not inherited by child concepts during classification. Associations are bidirectional and have a stated inverse. Unlike roles, associations do not have a domain or range.
http://purl.obolibrary.org/obo/NCIT_C99063	Spinal Cord Infarction	http://purl.obolibrary.org/obo/HP_0012639	Abnormal Nervous System Morphology		Ischemic necrosis of the spinal cord caused by occlusion of the arteries that supply blood to the spinal cord. Signs and symptoms include intermittent back pain, pain in the legs, paralysis, and incontinence.
http://purl.obolibrary.org/obo/NCIT_C115199	Cardiovascular Complication	http://purl.obolibrary.org/obo/NCIT_C2959	Complication		Any heart or vascular disorder occurring as a consequence of injury to the cardiovascular system.
http://purl.obolibrary.org/obo/NCIT_C115224	Hepatic Complication	http://purl.obolibrary.org/obo/NCIT_C2959	Complication		Any disorder of the liver occurring as a consequence of injury to the liver parenchyma.
http://purl.obolibrary.org/obo/NCIT_C115319	Ophthalmologic Complication	http://purl.obolibrary.org/obo/NCIT_C2959	Complication		Any eye disorder occurring as a consequence of injury to the eye.
http://purl.obolibrary.org/obo/NCIT_C116161	Multiplex Ligation-Dependent Probe Amplification	http://purl.obolibrary.org/obo/SCDO_0000913	Polymerase Chain Reaction		A type of high-throughput, multiplex PCR method used to determine abnormal DNA copy number changes of up to 50 genomic DNA or RNA sequences with a single pair of PCR primers. It is frequently used in the detection of genetic aberrations in tumors, and can distinguish sequences differing in only a single nucleotide.
http://purl.obolibrary.org/obo/NCIT_C116942	Developmental Delay	http://purl.obolibrary.org/obo/HP_0012759	Neurodevelopmental Abnormality		Failure to meet, or late achievement of developmental milestones.
http://purl.obolibrary.org/obo/NCIT_C122920	Intelligence Scale	http://purl.obolibrary.org/obo/NCIT_C91105	Clinical or Research Assessment Questionnaire		An assessment tool designed to measure an individual's cognitive capabilities. It may be general or it may assess abilities in more discrete cognitive domains.
http://purl.obolibrary.org/obo/NCIT_C17230	Ultrasound Test	http://purl.obolibrary.org/obo/OBI_0000185	Imaging Assay		A technique in which high-frequency sound waves are bounced off internal organs and the echo pattern is converted into a 2 dimensional picture of the structures beneath the transducer.
http://purl.obolibrary.org/obo/NCIT_C25474	Data	http://purl.obolibrary.org/obo/NCIT_C19332	Personal Attribute		A collection or single item of factual or reported information, derived from measurement or research, from which conclusions may be drawn.
http://purl.obolibrary.org/obo/NCIT_C3439	Viral Infection	http://purl.obolibrary.org/obo/IDO_0000586	Infection		Any disease caused by a virus.
http://purl.obolibrary.org/obo/NCIT_C131682	Sickle Cell Disease-SS	http://purl.obolibrary.org/obo/SCDO_1000106	Sickle Cell Disease		A variant of sickle cell disease due to homozygosity of the E6V mutation, amino acid substitution of valine for glutamic acid in the sixth position of the beta chain, resulting in the production of hemoglobin S from both alleles.
http://purl.obolibrary.org/obo/NCIT_C133543	Crizanlizumab	http://purl.obolibrary.org/obo/CHEBI_23888	Drug		A humanized monoclonal immunoglobulin G1 anti-P-selectin antibody with vaso-protective and anti-vaso-occlusive properties. Upon administration, crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand-1 (PSGL-1; SELPLG) on neutrophils and monocytes. P-selectin, a glycoprotein that functions as a cell adhesion molecule (CAM), translocates to the surface of activated endothelial cells and platelets, upon stimulation, where it binds to its ligand and mediates the rolling of platelets and neutrophils on activated endothelial cells. Therefore, blockade of p-selectin may inhibit platelet aggregation, maintain blood flow and minimize sickle cell-related pain crises (SCPC).
http://purl.obolibrary.org/obo/OBI_0002146	HIV Antibody Test	http://purl.obolibrary.org/obo/SCDO_0000571	HIV Test		An antigen specific antibodies assay that is meant to detect antibodies that bind to human immunodeficiency virus (HIV) antigens.
http://purl.obolibrary.org/obo/OBI_0002556	Minimum Age Value Specification	http://purl.obolibrary.org/obo/SCDO_1000401	Data Descriptor		A value specifcation that specifies the youngest age when specifying an age range.
http://purl.obolibrary.org/obo/OBI_0002557	Maximum Age Value Specification	http://purl.obolibrary.org/obo/SCDO_1000401	Data Descriptor		A value specifcation that specifies the oldest age when specifying an age range.
http://purl.obolibrary.org/obo/HP_0025546	Abnormal Mean Corpuscular Hemoglobin Concentration	http://purl.obolibrary.org/obo/HP_0001877	Abnormal Erythrocyte Morphology		Deviation from the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices.
http://purl.obolibrary.org/obo/HP_0025547	Decreased Mean Corpuscular Hemoglobin Concentration	http://purl.obolibrary.org/obo/HP_0025546	Abnormal Mean Corpuscular Hemoglobin Concentration		Less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices.
http://purl.obolibrary.org/obo/HP_0025548	Increased Mean Corpuscular Hemoglobin Concentration	http://purl.obolibrary.org/obo/HP_0025546	Abnormal Mean Corpuscular Hemoglobin Concentration		Greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices.
http://purl.obolibrary.org/obo/HP_0031368	Intestinal Perforation	http://purl.obolibrary.org/obo/SCDO_1000433	Intestinal Injury		A hole (perforation) in the wall of the intestine.
http://purl.obolibrary.org/obo/HP_0031456	Ectopic Pregnancy	http://purl.obolibrary.org/obo/NCIT_C34941	Pregnancy Complication		A pregnancy in which the fertilized egg inserts in a location outside of the main cavity of the uterus (usually in the Fallopian tube).
http://purl.obolibrary.org/obo/HP_0003611	Dyslipidemia	http://purl.obolibrary.org/obo/MP_0002118	Abnormal Lipid Homeostasis		Anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood.
http://purl.obolibrary.org/obo/DOID_2326	Gastroenteritis	http://purl.obolibrary.org/obo/IDO_0000586	Infection		A gastrointestinal system infectious disease that involves inflammation of the lining of the stomach and small and large intestines, which is caused by viruses, bacteria, or parasites. Chemicals and drugs also cause gastroenteritis. The symptoms include diarrhea, loss of appetite, nausea, vomiting, cramps, and discomfort in the abdomen.
http://purl.obolibrary.org/obo/DOID_813	Septic Arthritis	http://purl.obolibrary.org/obo/HP_0000924	Abnormality of the Skeletal System		An arthritis that involves infection by a pathogen located in a joint.
http://purl.obolibrary.org/obo/DOID_9220	Central Sleep Apnea	http://purl.obolibrary.org/obo/HP_0000708	Behavioural Abnormality		A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing.
http://purl.obolibrary.org/obo/HP_0000005	Mode of Inheritance	http://purl.obolibrary.org/obo/SCDO_0001000	SCDO		The pattern in which a particular genetic trait or disorder is passed from one generation to the next.
http://purl.obolibrary.org/obo/HP_0000006	Autosomal Dominant	http://purl.obolibrary.org/obo/HP_0000005	Mode of Inheritance		A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.
http://purl.obolibrary.org/obo/HP_0000007	Autosomal Recessive	http://purl.obolibrary.org/obo/HP_0000005	Mode of Inheritance		A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals with two pathogenic alleles, either homozygous (two copies of the same mutant allele) or compound heterozygous (whereby each copy of a gene has a distinct mutant allele).
http://purl.obolibrary.org/obo/HP_0000027	Azoospermia	http://purl.obolibrary.org/obo/HP_0000080	Abnormality of Reproductive System Physiology		Absence of any measurable level of sperm in a male's semen.
http://purl.obolibrary.org/obo/HP_0000044	Hypogonadotropic Hypogonadism	http://purl.obolibrary.org/obo/HP_0000080	Abnormality of Reproductive System Physiology		Hypogonadotropic hypogonadism is characterized by reduced function of the gonads (testes in males or ovaries in females) and results from the absence of the gonadal stimulating pituitary hormones: follicle stimulating hormone (FSH) and luteinizing hormone (LH).
http://purl.obolibrary.org/obo/HP_0000077	Abnormality of the Kidney	http://purl.obolibrary.org/obo/HP_0000079	Abnormality of the Urinary System		An abnormality of the kidney.
http://purl.obolibrary.org/obo/HP_0000078	Abnormality of the Genital System	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		An abnormality of the genital system.
http://purl.obolibrary.org/obo/HP_0000079	Abnormality of the Urinary System	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		An abnormality of the urinary system.
http://purl.obolibrary.org/obo/HP_0000080	Abnormality of Reproductive System Physiology	http://purl.obolibrary.org/obo/HP_0000078	Abnormality of the Genital System		An abnormal functionality of the genital system.
http://purl.obolibrary.org/obo/HP_0000096	Glomerulosclerosis	http://purl.obolibrary.org/obo/HP_0000077	Abnormality of the Kidney		Scarring and fibrosis within the glomerulus.
http://purl.obolibrary.org/obo/HP_0000097	Focal Segmental Glomerulosclerosis	http://purl.obolibrary.org/obo/HP_0000096	Glomerulosclerosis		Segmental accumulation of scar tissue in individual (but not all) glomeruli.
http://purl.obolibrary.org/obo/HP_0000099	Glomerulonephritis	http://purl.obolibrary.org/obo/HP_0000123	Nephritis		Inflammation of the renal glomeruli.
http://purl.obolibrary.org/obo/HP_0000112	Nephropathy	http://purl.obolibrary.org/obo/HP_0000077	Abnormality of the Kidney		A nonspecific term referring to disease or damage of the kidneys.
http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype	http://purl.obolibrary.org/obo/OGMS_0000023	Phenotype		A phenotype that shows detectable differences from normal.
http://purl.obolibrary.org/obo/HP_0000123	Nephritis	http://purl.obolibrary.org/obo/SCDO_1000383	Renal Complication		The presence of inflammation affecting the kidney.
http://purl.obolibrary.org/obo/HP_0000225	Gingival Bleeding	http://purl.obolibrary.org/obo/HP_0000271	Abnormality of the Face		Hemorrhage affecting the gingiva.
http://purl.obolibrary.org/obo/HP_0000388	Otitis Media	http://purl.obolibrary.org/obo/IDO_0000586	Infection		Inflammation or infection of the middle ear.
http://purl.obolibrary.org/obo/HP_0000478	Abnormality of the Eye	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		Any abnormality of the eye, including location, spacing, and intraocular abnormalities.
http://purl.obolibrary.org/obo/HP_0000505	Visual Impairment	http://purl.obolibrary.org/obo/HP_0000478	Abnormality of the Eye		Visual impairment (or vision impairment) is vision loss (of a person) to such a degree as to qualify as an additional support need through a significant limitation of visual capability resulting from either disease, trauma, or congenital or degenerative conditions that cannot be corrected by conventional means, such as refractive correction, medication, or surgery.
http://purl.obolibrary.org/obo/HP_0000708	Behavioural Abnormality	http://purl.obolibrary.org/obo/HP_0012638	Abnormal Nervous System Physiology		An abnormality of mental functioning including various affective, behavioural, cognitive and perceptual abnormalities.
http://purl.obolibrary.org/obo/HP_0000726	Dementia	http://purl.obolibrary.org/obo/HP_0012638	Abnormal Nervous System Physiology		A loss of global cognitive ability of sufficient amount to interfere with normal social or occupational function. Dementia represents a loss of previously present cognitive abilities, generally in adults, and can affect memory, thinking, language, judgment, and behavior.
http://purl.obolibrary.org/obo/HP_0000763	Sensory Neuropathy	http://purl.obolibrary.org/obo/HP_0009830	Peripheral Neuropathy		Peripheral neuropathy affecting the sensory nerves.
http://purl.obolibrary.org/obo/HP_0000789	Infertility	http://purl.obolibrary.org/obo/HP_0000080	Abnormality of Reproductive System Physiology		Inability to produce live offspring.
http://purl.obolibrary.org/obo/HP_0000798	Oligospermia	http://purl.obolibrary.org/obo/HP_0000080	Abnormality of Reproductive System Physiology		Reduced count of spermatozoa in the semen, defined as a sperm count below 20 million per milliliter semen.
http://purl.obolibrary.org/obo/HP_0000805	Enuresis	http://purl.obolibrary.org/obo/SCDO_0000954	Quality of Life Related SCD Symptoms and Complications		Lack of the ability to control the urinary bladder leading to involuntary urination at an age where control of the bladder should already be possible.
http://purl.obolibrary.org/obo/HP_0000815	Hypergonadotropic Hypogonadism	http://purl.obolibrary.org/obo/HP_0000080	Abnormality of Reproductive System Physiology		Reduced function of the gonads (testes in males or ovaries in females) associated with excess pituitary gonadotropin secretion and resulting in delayed sexual development and growth delay.
http://purl.obolibrary.org/obo/HP_0000818	Abnormality of the Endocrine System	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		An abnormality of the endocrine system.
http://purl.obolibrary.org/obo/HP_0000820	Abnormality of the Thyroid Gland	http://purl.obolibrary.org/obo/HP_0000818	Abnormality of the Endocrine System		An abnormality of the thyroid gland.
http://purl.obolibrary.org/obo/HP_0000821	Hypothyroidism	http://purl.obolibrary.org/obo/HP_0000820	Abnormality of the Thyroid Gland		Deficiency of thyroid hormone.
http://purl.obolibrary.org/obo/HP_0000822	Hypertension	http://purl.obolibrary.org/obo/HP_0011025	Abnormal Cardiovascular System Physiology		The presence of chronic increased pressure in the systemic arterial system.
http://purl.obolibrary.org/obo/HP_0000823	Delayed Puberty	http://purl.obolibrary.org/obo/SCDO_0000954	Quality of Life Related SCD Symptoms and Complications		Passing the age when puberty normally occurs with no physical or hormonal signs of the onset of puberty.
http://purl.obolibrary.org/obo/HP_0000824	Growth Hormone Deficiency	http://purl.obolibrary.org/obo/HP_0000818	Abnormality of the Endocrine System		Insufficient production of growth hormone, which is produced by the anterior pituitary gland. Growth hormone is a major participant in control of growth and metabolism.
http://purl.obolibrary.org/obo/HP_0000828	Abnormality of the Parathyroid Gland	http://purl.obolibrary.org/obo/HP_0000818	Abnormality of the Endocrine System		An abnormality of the parathyroid gland.
http://purl.obolibrary.org/obo/HP_0000829	Hypoparathyroidism	http://purl.obolibrary.org/obo/HP_0000828	Abnormality of the Parathyroid Gland		A condition caused by a deficiency of parathyroid hormone characterized by hypocalcemia and hyperphosphatemia.
http://purl.obolibrary.org/obo/HP_0000834	Abnormality of the Adrenal Glands	http://purl.obolibrary.org/obo/HP_0000818	Abnormality of the Endocrine System		Abnormality of the adrenal glands, i.e., of the endocrine glands located at the top of the kidneys.
http://purl.obolibrary.org/obo/HP_0000836	Hyperthyroidism	http://purl.obolibrary.org/obo/HP_0000820	Abnormality of the Thyroid Gland		An abnormality of thyroid physiology characterized by excessive secretion of the thyroid hormones thyroxine (i.e., T4) and/or 3,3',5-triiodo-L-thyronine zwitterion (i.e., triiodothyronine or T3).
http://purl.obolibrary.org/obo/HP_0000842	Hyperinsulinemia	http://purl.obolibrary.org/obo/HP_0011014	Abnormal Glucose Homeostasis		An increased concentration of insulin in the blood.
http://purl.obolibrary.org/obo/HP_0000843	Hyperparathyroidism	http://purl.obolibrary.org/obo/HP_0000828	Abnormality of the Parathyroid Gland		Excessive production of parathyroid hormone (PTH) by the parathyroid glands.
http://purl.obolibrary.org/obo/HP_0000855	Insulin Resistance	http://purl.obolibrary.org/obo/HP_0011014	Abnormal Glucose Homeostasis		Increased resistance towards insulin, that is, diminished effectiveness of insulin in reducing blood glucose levels.
http://purl.obolibrary.org/obo/HP_0000873	Diabetes Insipidus	http://purl.obolibrary.org/obo/HP_0000818	Abnormality of the Endocrine System		A state of excessive water excretion and hypotonic (dilute) polyuria. Diabetes insipidus may be due to failure of vasopressin (AVP) release (central or neurogenic diabetes insipidus) or to a failure of the kidney to respond to AVP (nephrogenic diabetes insipidus).
http://purl.obolibrary.org/obo/HP_0000876	Oligomenorrhea	http://purl.obolibrary.org/obo/HP_0012243	Abnormal Reproductive System Morphology		Infrequent menses (less than 6 per year or more than 35 days between cycles).
http://purl.obolibrary.org/obo/HP_0000938	Osteopenia	http://purl.obolibrary.org/obo/HP_0000924	Abnormality of the Skeletal System		Osteopenia is a term to define bone density that is not normal but also not as low as osteoporosis. By definition from the World Health Organization osteopenia is defined by bone densitometry as a T score -1 to -2.5.
http://purl.obolibrary.org/obo/HP_0000939	Osteoporosis	http://purl.obolibrary.org/obo/HP_0000924	Abnormality of the Skeletal System		Osteoporosis is a systemic skeletal disease characterized by low bone density and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility. According to the WHO criteria, osteoporosis is defined as a BMD that lies 2.5 standard deviations or more below the average value for young healthy adults (a T-score below -2.5 SD).
http://purl.obolibrary.org/obo/HP_0000951	Abnormality of the Skin	http://purl.obolibrary.org/obo/HP_0001574	Abnormality of the Integument		An abnormality of the skin.
http://purl.obolibrary.org/obo/HP_0000953	Cutaneous Hyperpigmentation	http://purl.obolibrary.org/obo/HP_0011121	Abnormality of Skin Morphology		A darkening of the skin related to an increase in melanin production and deposition.
http://purl.obolibrary.org/obo/HP_0000961	Cyanosis	http://purl.obolibrary.org/obo/HP_0011121	Abnormality of Skin Morphology		Bluish discoloration of the skin and mucosa due to poor circulation or inadequate oxygenation of arterial or capillary blood.
http://purl.obolibrary.org/obo/HP_0000980	Pallor	http://purl.obolibrary.org/obo/HP_0011121	Abnormality of Skin Morphology		Abnormally pale skin.
http://purl.obolibrary.org/obo/HP_0001010	Hypopigmentation	http://purl.obolibrary.org/obo/HP_0011121	Abnormality of Skin Morphology		A reduction of skin color related to a decrease in melanin production and deposition.
http://purl.obolibrary.org/obo/HP_0001061	Acne	http://purl.obolibrary.org/obo/HP_0011123	Skin Inflammation		A skin condition in which there is an increase in sebum secretion by the pilosebaceous apparatus associated with open comedones (blackheads), closed comedones (whiteheads), and pustular nodules (papules, pustules, and cysts).
http://purl.obolibrary.org/obo/HP_0001081	Cholelithiasis	http://purl.obolibrary.org/obo/HP_0025031	Abnormality of the Digestive System		Hard, pebble-like deposits that form within the gallbladder.
http://purl.obolibrary.org/obo/HP_0001197	Abnormality of Prenatal Development or Birth	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		An abnormality of the fetus or the birth of the fetus, excluding structural abnormalities.
http://purl.obolibrary.org/obo/HP_0001265	Hyporeflexia	http://purl.obolibrary.org/obo/HP_0012638	Abnormal Nervous System Physiology		Reduction of neurologic reflexes such as the knee-jerk reaction.
http://purl.obolibrary.org/obo/HP_0001271	Polyneuropathy	http://purl.obolibrary.org/obo/HP_0009830	Peripheral Neuropathy		A generalized disorder of peripheral nerves.
http://purl.obolibrary.org/obo/HP_0001279	Syncope	http://purl.obolibrary.org/obo/HP_0011025	Abnormal Cardiovascular System Physiology		Syncope refers to a generalized weakness of muscles with loss of postural tone, inability to stand upright, and loss of consciousness. Once the patient is in a horizontal position, blood flow to the brain is no longer hindered by gravitation and consciousness is regained. Unconsciousness usually lasts for seconds to minutes. Headache and drowsiness (which usually follow seizures) do not follow a syncopal attack. Syncope results from a sudden impairment of brain metabolism usually due to a reduction in cerebral blood flow.
http://purl.obolibrary.org/obo/HP_0001298	Encephalopathy	http://purl.obolibrary.org/obo/HP_0012638	Abnormal Nervous System Physiology		A term that means brain disease, damage, or malfunction. In general, it is manifested by an altered mental state.
http://purl.obolibrary.org/obo/HP_0001342	Cerebral Hemorrhage	http://purl.obolibrary.org/obo/HP_0002170	Intracranial Hemorrhage		Hemorrhage into the parenchyma of the brain.
http://purl.obolibrary.org/obo/HP_0001343	Kernicterus	http://purl.obolibrary.org/obo/HP_0012639	Abnormal Nervous System Morphology		Damage to cerebral nuclei caused in infants by highly increased levels of unconjugated bilirubin. The basal ganglia and brainstem nuclei could be shown to have a yellow staining historically in infants who died of kernicterus, that is, kernicterus is strictly speaking a pathological diagnosis. The presence of kernicterus may be inferred in infants with characteristic acute or chronic bilirubin-induced neurological dysfunction.
http://purl.obolibrary.org/obo/HP_0001371	Flexion Contracture	http://purl.obolibrary.org/obo/HP_0000924	Abnormality of the Skeletal System		A flexion contracture is a bent (flexed) joint that cannot be straightened actively or passively. It is thus a chronic loss of joint motion due to structural changes in muscle, tendons, ligaments, or skin that prevents normal movement of joints.
http://purl.obolibrary.org/obo/HP_0001382	Joint Hypermobility	http://purl.obolibrary.org/obo/HP_0000924	Abnormality of the Skeletal System		The ability of a joint to move beyond its normal range of motion.
http://purl.obolibrary.org/obo/HP_0001392	Abnormality of the Liver	http://purl.obolibrary.org/obo/HP_0025031	Abnormality of the Digestive System		An abnormality of the liver.
http://purl.obolibrary.org/obo/HP_0001394	Cirrhosis	http://purl.obolibrary.org/obo/HP_0001392	Abnormality of the Liver		A chronic disorder of the liver in which liver tissue becomes scarred and is partially replaced by regenerative nodules and fibrotic tissue resulting in loss of liver function.
http://purl.obolibrary.org/obo/HP_0001395	Hepatic Fibrosis	http://purl.obolibrary.org/obo/HP_0001392	Abnormality of the Liver		The presence of excessive fibrous connective tissue in the liver. Fibrosis is a reparative or reactive process.
http://purl.obolibrary.org/obo/HP_0001406	Intrahepatic Cholestasis	http://purl.obolibrary.org/obo/HP_0001392	Abnormality of the Liver		Impairment of bile flow due to obstruction in the small bile ducts within the liver.
http://purl.obolibrary.org/obo/HP_0001507	Growth Abnormality	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		Abnormality of growth.
http://purl.obolibrary.org/obo/HP_0001511	Intrauterine Growth Restriction	http://purl.obolibrary.org/obo/HP_0001507	Growth Abnormality		An abnormal restriction of fetal growth with fetal weight below the tenth percentile for gestational age.
http://purl.obolibrary.org/obo/HP_0001574	Abnormality of the Integument	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		An abnormality of the integument, which consists of the skin and the superficial fascia.
http://purl.obolibrary.org/obo/HP_0001622	Preterm Delivery	http://purl.obolibrary.org/obo/HP_0001197	Abnormality of Prenatal Development or Birth		The birth of a baby of less than 37 weeks of gestational age.
http://purl.obolibrary.org/obo/HP_0001626	Abnormality of Cardiovascular System	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		Any abnormality of the cardiovascular system.
http://purl.obolibrary.org/obo/HP_0001635	Cardiac Failure	http://purl.obolibrary.org/obo/HP_0011025	Abnormal Cardiovascular System Physiology		The presence of an abnormality of cardiac function that is responsible for the failure of the heart to pump blood at a rate that is commensurate with the needs of the tissues or a state in which abnormally elevated filling pressures are required for the heart to do so. Heart failure is frequently related to a defect in myocardial contraction.
http://purl.obolibrary.org/obo/HP_0001640	Cardiomegaly	http://purl.obolibrary.org/obo/HP_0030680	Abnormal Cardiovascular System Morphology		Increased size of the heart.
http://purl.obolibrary.org/obo/HP_0001658	Myocardial Infarction	http://purl.obolibrary.org/obo/HP_0011025	Abnormal Cardiovascular System Physiology		Necrosis of the myocardium caused by an obstruction of the blood supply to the heart and often associated with chest pain, shortness of breath, palpitations, and anxiety as well as characteristic EKG findings and elevation of serum markers including creatine kinase-MB fraction and troponin.
http://purl.obolibrary.org/obo/HP_0001701	Pericarditis	http://purl.obolibrary.org/obo/HP_0011025	Abnormal Cardiovascular System Physiology		Inflammation of the sac-like covering around the heart (pericardium).
http://purl.obolibrary.org/obo/HP_0001712	Left Ventricular Hypertrophy	http://purl.obolibrary.org/obo/HP_0001714	Ventricular Hypertrophy		Enlargement or increased size of the heart left ventricle.
http://purl.obolibrary.org/obo/HP_0001714	Ventricular Hypertrophy	http://purl.obolibrary.org/obo/HP_0030680	Abnormal Cardiovascular System Morphology		Enlargement of the cardiovascular ventricular muscle tissue with increase in the width of the wall of the ventricle and loss of elasticity. Ventricular hypertrophy is clinically differentiated into left and right ventricular hypertrophy.
http://purl.obolibrary.org/obo/HP_0001743	Abnormality of the Spleen	http://purl.obolibrary.org/obo/HP_0025031	Abnormality of the Digestive System		An abnormality of the spleen.
http://purl.obolibrary.org/obo/HP_0001787	Abnormal Delivery	http://purl.obolibrary.org/obo/HP_0001197	Abnormality of Prenatal Development or Birth		An abnormality of the birth process.
http://purl.obolibrary.org/obo/HP_0001871	Abnormality of Blood and Blood-Forming Tissues	http://purl.obolibrary.org/obo/SCDO_1000820	Hematopoietic System Phenotype		An abnormality of the hematopoietic system.
http://purl.obolibrary.org/obo/HP_0001872	Abnormal Thrombocyte Morphology	http://purl.obolibrary.org/obo/HP_0001871	Abnormality of Blood and Blood-Forming Tissues		An abnormality of platelets. Platelets, also known as thrombocytes, are non-nucleated disk-shaped cells mainly involved in blood coagulation.
http://purl.obolibrary.org/obo/HP_0001874	Abnormality of Neutrophils	http://purl.obolibrary.org/obo/HP_0001871	Abnormality of Blood and Blood-Forming Tissues		A neutrophil abnormality.
http://purl.obolibrary.org/obo/HP_0001875	Neutropenia	http://purl.obolibrary.org/obo/HP_0011991	Abnormal Neutrophil Count		An abnormally low number of neutrophils in the peripheral blood.
http://purl.obolibrary.org/obo/HP_0001877	Abnormal Erythrocyte Morphology	http://purl.obolibrary.org/obo/HP_0001871	Abnormality of Blood and Blood-Forming Tissues		Any structural abnormality of erythrocytes (red-blood cells).
http://purl.obolibrary.org/obo/HP_0001878	Hemolytic Anemia	http://purl.obolibrary.org/obo/HP_0001903	Anemia		A type of anemia caused by premature destruction of red blood cells (hemolysis).
http://purl.obolibrary.org/obo/HP_0001894	Thrombocytosis	http://purl.obolibrary.org/obo/HP_0011873	Abnormal Platelet Count		Thrombocythemia and thrombocytosis are conditions with a higher than normal number of platelets. The term "thrombocythemia" is preferred when the cause of a high platelet count isn't known. The condition sometimes is called primary or essential thrombocythemia. Increased numbers of platelets in the peripheral blood.
http://purl.obolibrary.org/obo/HP_0001896	Reticulocytopenia	http://purl.obolibrary.org/obo/HP_0004312	Abnormality of Reticulocytes		A reduced number of reticulocytes in the peripheral blood.
http://purl.obolibrary.org/obo/HP_0001909	Leukaemia	http://purl.obolibrary.org/obo/OBI_1110053	Cancer		A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes.
http://purl.obolibrary.org/obo/HP_0001919	Acute Kidney Injury	http://purl.obolibrary.org/obo/HP_0000084	Kidney Failure		Sudden loss of renal function, as manifested by decreased urine production, and a rise in serum creatinine or blood urea nitrogen concentration (azotemia).
http://purl.obolibrary.org/obo/HP_0001920	Renal Artery Stenosis	http://purl.obolibrary.org/obo/HP_0000077	Abnormality of the Kidney		The presence of stenosis of the renal artery.
http://purl.obolibrary.org/obo/HP_0001923	Reticulocytosis	http://purl.obolibrary.org/obo/HP_0004312	Abnormality of Reticulocytes		An elevation in the number of reticulocytes (immature erythrocytes) in the peripheral blood circulation.
http://purl.obolibrary.org/obo/HP_0001931	Hypochromic Anemia	http://purl.obolibrary.org/obo/HP_0001903	Anemia		A type of anemia characterized by an abnormally low concentration of hemoglobin in the erythrocytes.
http://purl.obolibrary.org/obo/HP_0001935	Microcytic Anemia	http://purl.obolibrary.org/obo/HP_0001903	Anemia		A kind of anemia in which the volume of the red blood cells is reduced.
http://purl.obolibrary.org/obo/HP_0001943	Hypoglycemia	http://purl.obolibrary.org/obo/HP_0011014	Abnormal Glucose Homeostasis		A decreased concentration of glucose in the blood.
http://purl.obolibrary.org/obo/HP_0001953	Diabetic Ketoacidosis	http://purl.obolibrary.org/obo/HP_0000819	Diabetes Mellitus		A type of diabetic metabolic abnormality with an accumulation of ketone bodies.
http://purl.obolibrary.org/obo/HP_0001970	Interstitial Nephritis	http://purl.obolibrary.org/obo/HP_0000123	Nephritis		A form of inflammation of the kidney affecting the interstitium of the kidneys surrounding the tubules.
http://purl.obolibrary.org/obo/HP_0001999	Facial Dysmorphisms	http://purl.obolibrary.org/obo/HP_0000271	Abnormality of the Face		An abnormal morphology (form) of the face or its components.
http://purl.obolibrary.org/obo/HP_0002007	Frontal Bossing	http://purl.obolibrary.org/obo/HP_0000924	Abnormality of the Skeletal System		Bilateral bulging of the lateral frontal bone prominences with relative sparing of the midline.
http://purl.obolibrary.org/obo/HP_0002014	Diarrhea	http://purl.obolibrary.org/obo/HP_0025031	Abnormality of the Digestive System		Abnormally increased frequency of loose or watery bowel movements.
http://purl.obolibrary.org/obo/HP_0002019	Constipation	http://purl.obolibrary.org/obo/HP_0025031	Abnormality of the Digestive System		Infrequent or difficult evacuation of feces.
http://purl.obolibrary.org/obo/HP_0002059	Cerebral Atrophy	http://purl.obolibrary.org/obo/HP_0002060	Abnormality of the Cerebrum		Atrophy (wasting, decrease in size of cells or tissue) affecting the cerebrum.
http://purl.obolibrary.org/obo/HP_0002060	Abnormality of the Cerebrum	http://purl.obolibrary.org/obo/HP_0012639	Abnormal Nervous System Morphology		An abnormality of the telencephalon, which is also known as the cerebrum.
http://purl.obolibrary.org/obo/HP_0002067	Bradykinesia	http://purl.obolibrary.org/obo/HP_0012638	Abnormal Nervous System Physiology		Bradykinesia literally means slow movement, and is used clinically to denote a slowness in the execution of movement (in contrast to hypokinesia, which is used to refer to slowness in the initiation of movement).
http://purl.obolibrary.org/obo/HP_0002071	Extrapyramidal Symptoms	http://purl.obolibrary.org/obo/HP_0012638	Abnormal Nervous System Physiology		A neurological condition related to lesions of the basal ganglia leading to typical abnormalities including akinesia (inability to initiate changes in activity and perform volitional movements rapidly and easily), muscular rigidity (continuous contraction of muscles with constant resistance to passive movement), chorea (widespread arrhythmic movements of a forcible, rapid, jerky, and restless nature), athetosis (inability to sustain the muscles of the fingers, toes, or other group of muscles in a fixed position), and akathisia (inability to remain motionless).
http://purl.obolibrary.org/obo/HP_0002076	Migraine	http://purl.obolibrary.org/obo/HP_0012638	Abnormal Nervous System Physiology		Migraine is a chronic neurological disorder characterized by episodic attacks of headache and associated symptoms.
http://purl.obolibrary.org/obo/HP_0002086	Abnormality of the Respiratory System	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		An abnormality of the respiratory system, which include the airways, lungs, and the respiratory muscles.
http://purl.obolibrary.org/obo/HP_0002138	Subarachnoid Hemorrhage	http://purl.obolibrary.org/obo/HP_0002170	Intracranial Hemorrhage		Hemorrhage occurring between the arachnoid mater and the pia mater.
http://purl.obolibrary.org/obo/HP_0002157	Azotaemia	http://purl.obolibrary.org/obo/HP_0004364	Abnormal Circulating Nitrogen Compound Concentration		An increased concentration of nitrogen compounds in the blood.
http://purl.obolibrary.org/obo/HP_0002170	Intracranial Hemorrhage	http://purl.obolibrary.org/obo/SCDO_1000037	Abnormality of the Cerebral Vasculature		Hemorrhage occurring within the skull.
http://purl.obolibrary.org/obo/HP_0002181	Cerebral Edema	http://purl.obolibrary.org/obo/HP_0000969	Edema		Abnormal accumulation of fluid in the brain.
http://purl.obolibrary.org/obo/HP_0002240	Hepatomegaly	http://purl.obolibrary.org/obo/HP_0001392	Abnormality of the Liver		Abnormally increased size of the liver.
http://purl.obolibrary.org/obo/HP_0002341	Cervical Cord Compression	http://purl.obolibrary.org/obo/HP_0012639	Abnormal Nervous System Morphology		Compression of the spinal cord in the cervical region, generally manifested by paresthesias and numbness, weakness, difficulty walking, abnormalities of coordination, and neck pain or stiffness.
http://purl.obolibrary.org/obo/HP_0002427	Motor Aphasia	http://purl.obolibrary.org/obo/HP_0012638	Abnormal Nervous System Physiology		Impairment of expressive language and relative preservation of receptive language abilities. That is, the patient understands language (speech, writing) but cannot express it.
http://purl.obolibrary.org/obo/HP_0002516	Intracranial Hypertension	http://purl.obolibrary.org/obo/HP_0012638	Abnormal Nervous System Physiology		An increase of the pressure inside the cranium (skull) and thereby in the brain tissue and cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0002597	Abnormality of the Vasculature	http://purl.obolibrary.org/obo/HP_0001626	Abnormality of Cardiovascular System		An abnormality of the vasculature.
http://purl.obolibrary.org/obo/HP_0002659	Bone Fragility	http://purl.obolibrary.org/obo/HP_0000924	Abnormality of the Skeletal System		An abnormally increased tendency to fractures of bones caused by an abnormal reduction in bone strength that is generally associated with an increased risk of fracture.
http://purl.obolibrary.org/obo/HP_0002665	Lymphoma	http://purl.obolibrary.org/obo/OBI_1110053	Cancer		A cancer originating in lymphocytes and presenting as a solid tumor of lymphoid cells.
http://purl.obolibrary.org/obo/HP_0002715	Abnormality of the Immune System	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		An abnormality of the immune system.
http://purl.obolibrary.org/obo/HP_0002808	Kyphosis	http://purl.obolibrary.org/obo/HP_0000924	Abnormality of the Skeletal System		Exaggerated anterior convexity of the thoracic vertebral column.
http://purl.obolibrary.org/obo/HP_0002870	Obstructive Sleep Apnea	http://purl.obolibrary.org/obo/HP_0000708	Behavioural Abnormality		A condition characterized by obstruction of the airway and by pauses in breathing during sleep occurring many times during the night. Obstructive sleep apnea is related to a relaxation of muscle tone (which normally occurs during sleep) leading to partial collapse of the soft tissues in the airway with resultant obstruction of the air flow.
http://purl.obolibrary.org/obo/HP_0002907	Microscopic Hematuria	http://purl.obolibrary.org/obo/SCDO_0000508	Hematuria		Microscopic hematuria detected by dipstick or microscopic examination of the urine.
http://purl.obolibrary.org/obo/HP_0002913	Myoglobinuria	http://purl.obolibrary.org/obo/HP_0000079	Abnormality of the Urinary System		Presence of myoglobin in the urine.
http://purl.obolibrary.org/obo/HP_0002955	Granulomatosis	http://purl.obolibrary.org/obo/IDO_0000586	Infection		Any disease characterized by the formation of numerous granulomas.
http://purl.obolibrary.org/obo/HP_0003077	Hyperlipidemia	http://purl.obolibrary.org/obo/HP_0003611	Dyslipidemia		An elevated lipid concentration in the blood.
http://purl.obolibrary.org/obo/HP_0003110	Abnormal Urine Homeostasis	http://purl.obolibrary.org/obo/SCDO_0002674	Abnormality of Metabolism/Homeostasis		An abnormality of the composition of urine or the levels of its components.
http://purl.obolibrary.org/obo/HP_0003116	Abnormal Echocardiogram	http://purl.obolibrary.org/obo/HP_0500015	Abnormal Cardiac Test		An abnormality detectable by sonography of the heart (echocardiography).
http://purl.obolibrary.org/obo/HP_0003126	Tubular Proteinuria	http://purl.obolibrary.org/obo/SCDO_0000932	Proteinuria		Excretion in urine of proteins of a size smaller than albumin (molecular weight 69 kD).
http://purl.obolibrary.org/obo/HP_0003155	Elevated Serum Alkaline Phosphatase	http://purl.obolibrary.org/obo/HP_0004379	Abnormality of Alkaline Phosphatase Level		Abnormally increased serum levels of alkaline phosphatase activity.
http://purl.obolibrary.org/obo/HP_0003158	Hyposthenuria	http://purl.obolibrary.org/obo/HP_0004727	Impaired Renal Concentrating Ability		An abnormally low urinary specific gravity, i.e., reduced concentration of solutes in the urine.
http://purl.obolibrary.org/obo/HP_0003198	Myopathy	http://purl.obolibrary.org/obo/SCDO_1000268	Abnormality of the Musculature		A disorder of muscle unrelated to impairment of innervation or neuromuscular junction.
http://purl.obolibrary.org/obo/HP_0003265	Neonatal Hyperbilirubinemia	http://purl.obolibrary.org/obo/NCIT_C27088	Hyperbilirubinemia		A type of hyperbilirubinemia with neonatal onset.
http://purl.obolibrary.org/obo/HP_0003282	Decreased Serum Alkaline Phosphatase	http://purl.obolibrary.org/obo/HP_0004379	Abnormality of Alkaline Phosphatase Level		Abnormally reduced serum levels of alkaline phosphatase.
http://purl.obolibrary.org/obo/HP_0003302	Spondylolisthesis	http://purl.obolibrary.org/obo/HP_0000924	Abnormality of the Skeletal System		Complete bilateral fractures of the pars interarticularis resulting in the anterior slippage of the vertebra.
http://purl.obolibrary.org/obo/HP_0003394	Muscle Cramps	http://purl.obolibrary.org/obo/SCDO_1000268	Abnormality of the Musculature		Sudden and involuntary contractions of one or more muscles.
http://purl.obolibrary.org/obo/HP_0003457	EMG Abnormality	http://purl.obolibrary.org/obo/SCDO_1000268	Abnormality of the Musculature		Abnormal results of investigations using electromyography (EMG).
http://purl.obolibrary.org/obo/HP_0003563	Decreased Circulating LDL Cholesterol Level	http://purl.obolibrary.org/obo/HP_0003611	Dyslipidemia		Reduced amount in the blood of the lipoprotein:cholesterol complex that transports cholesterol out of the arteries and around the body, for use by various tissues in normal bodily functions.
http://purl.obolibrary.org/obo/HP_0003573	Increased Total Bilirubin	http://purl.obolibrary.org/obo/NCIT_C27088	Hyperbilirubinemia		Increased concentration of total (conjugated and unconjugated) bilirubin in the blood.
http://purl.obolibrary.org/obo/HP_0003641	Hemoglobinuria	http://purl.obolibrary.org/obo/SCDO_1000383	Renal Complication		The presence of free hemoglobin in the urine.
http://purl.obolibrary.org/obo/HP_0003765	Psoriasis	http://purl.obolibrary.org/obo/HP_0011122	Abnormality of Skin Physiology		A skin abnormality characterized by redness and irritation, with thick, red skin that displays flaky, silver-white patches (scales).
http://purl.obolibrary.org/obo/HP_0003774	End Stage Kidney Disease	http://purl.obolibrary.org/obo/SCDO_0000226	Chronic Kidney Disease		A degree of kidney failure severe enough to require dialysis or kidney transplantation for survival characterized by a severe reduction in glomerular filtration rate (less than 15 ml/min/1.73 m2) and other manifestations including increased serum creatinine, greater than 3 months.
http://purl.obolibrary.org/obo/HP_0004312	Abnormality of Reticulocytes	http://purl.obolibrary.org/obo/HP_0001877	Abnormal Erythrocyte Morphology		A reticulocyte abnormality.
http://purl.obolibrary.org/obo/HP_0004364	Abnormal Circulating Nitrogen Compound Concentration	http://purl.obolibrary.org/obo/HP_0032180	Abnormal Circulating Metabolite Concentration		Any deviation from the normal concentration of a nitrogen compound in the blood circulation.
http://purl.obolibrary.org/obo/HP_0004379	Abnormality of Alkaline Phosphatase Level	http://purl.obolibrary.org/obo/HP_0012379	Abnormal Enzyme/Coenzyme Activity		An abnormality of alkaline phosphatase level.
http://purl.obolibrary.org/obo/HP_0004447	Poikilocytosis	http://purl.obolibrary.org/obo/HP_0001877	Abnormal Erythrocyte Morphology		The presence of abnormally shaped erythrocytes.
http://purl.obolibrary.org/obo/HP_0004586	Biconcave Vertebral Bodies	http://purl.obolibrary.org/obo/HP_0000924	Abnormality of the Skeletal System		Exaggerated concavity of the anterior or posterior surface of the vertebral body, i.e., the upper and lower vertebral endplates are hollowed inward.
http://purl.obolibrary.org/obo/HP_0008404	Nail Dystrophy	http://purl.obolibrary.org/obo/HP_0001574	Abnormality of the Integument		Onychodystrophy (nail dystrophy) refers to nail changes apart from changes of the color (nail dyschromia) and involves partial or complete disruption of the various keratinous layers of the nail plate.
http://purl.obolibrary.org/obo/HP_0009830	Peripheral Neuropathy	http://purl.obolibrary.org/obo/HP_0012639	Abnormal Nervous System Morphology		Peripheral neuropathy is a general term for any disorder of the peripheral nervous system.
http://purl.obolibrary.org/obo/HP_0010628	Facial Nerve Palsy	http://purl.obolibrary.org/obo/HP_0000271	Abnormality of the Face		Facial nerve palsy is a dysfunction of cranial nerve VII (the facial nerve) that results in inability to control facial muscles on the affected side with weakness of the muscles of facial expression and eye closure. This can either be present in unilateral or bilateral form.
http://purl.obolibrary.org/obo/HP_0010876	Abnormal Circulating Protein Level	http://purl.obolibrary.org/obo/HP_0032180	Abnormal Circulating Metabolite Concentration		An abnormal level of a circulating protein in the blood.
http://purl.obolibrary.org/obo/HP_0011007	Age of Onset	http://purl.obolibrary.org/obo/NCIT_C43646	Association		The age group in which disease manifestations appear.
http://purl.obolibrary.org/obo/HP_0011014	Abnormal Glucose Homeostasis	http://purl.obolibrary.org/obo/SCDO_0002674	Abnormality of Metabolism/Homeostasis		Abnormality of glucose homeostasis.
http://purl.obolibrary.org/obo/HP_0011025	Abnormal Cardiovascular System Physiology	http://purl.obolibrary.org/obo/HP_0001626	Abnormality of Cardiovascular System		Abnormal functionality of the cardiovascular system.
http://purl.obolibrary.org/obo/HP_0011121	Abnormality of Skin Morphology	http://purl.obolibrary.org/obo/HP_0000951	Abnormality of the Skin		Any morphological abnormality of the skin.
http://purl.obolibrary.org/obo/HP_0011122	Abnormality of Skin Physiology	http://purl.obolibrary.org/obo/HP_0000951	Abnormality of the Skin		Any abnormality of the physiological function of the skin.
http://purl.obolibrary.org/obo/HP_0011675	Arrhythmia	http://purl.obolibrary.org/obo/HP_0011025	Abnormal Cardiovascular System Physiology		Any cardiac rhythm other than the normal sinus rhythm. Such a rhythm may be either of sinus or ectopic origin and either regular or irregular. An arrhythmia may be due to a disturbance in impulse formation or conduction or both.
http://purl.obolibrary.org/obo/HP_0011873	Abnormal Platelet Count	http://purl.obolibrary.org/obo/HP_0001872	Abnormal Thrombocyte Morphology		Abnormal number of platelets per volume of blood. In a healthy adult, a normal platelet count is between 150,000 and 450,000 per microliter of blood.
http://purl.obolibrary.org/obo/HP_0011893	Abnormal Leukocyte Count	http://purl.obolibrary.org/obo/SCDO_1000612	Abnormal Leukocyte Morphology		Number of leukocytes per volume of blood beyond normal limits.
http://purl.obolibrary.org/obo/HP_0011991	Abnormal Neutrophil Count	http://purl.obolibrary.org/obo/HP_0002715	Abnormality of the Immune System		A deviation from the normal range of neutrophil cell counts in the circulation.
http://purl.obolibrary.org/obo/HP_0012100	Abnormal Circulating Creatinine Level	http://purl.obolibrary.org/obo/HP_0004364	Abnormal Circulating Nitrogen Compound Concentration		An abnormal concentration of creatinine in the blood.
http://purl.obolibrary.org/obo/HP_0012243	Abnormal Reproductive System Morphology	http://purl.obolibrary.org/obo/HP_0000078	Abnormality of the Genital System		A structural or developmental anomaly of any of the tissues involved in the genital system.
http://purl.obolibrary.org/obo/HP_0012444	Atrophic Brain	http://purl.obolibrary.org/obo/HP_0012639	Abnormal Nervous System Morphology		Partial or complete wasting (loss) of brain tissue that was once present.
http://purl.obolibrary.org/obo/HP_0012638	Abnormal Nervous System Physiology	http://purl.obolibrary.org/obo/HP_0000707	Abnormality of the Nervous System		A functional anomaly of the nervous system.
http://purl.obolibrary.org/obo/HP_0012639	Abnormal Nervous System Morphology	http://purl.obolibrary.org/obo/HP_0000707	Abnormality of the Nervous System		A structural anomaly of the nervous system.
http://purl.obolibrary.org/obo/HP_0200042	Skin Ulcer	http://purl.obolibrary.org/obo/SCDO_0000954	Quality of Life Related SCD Symptoms and Complications		A discontinuity of the skin exhibiting loss of the epidermis and often portions of the dermis and subcutaneous fat.
http://purl.obolibrary.org/obo/GAZ_00000448	Geographic Location	http://purl.obolibrary.org/obo/SCDO_0000897	Physical Environment		A reference to a place on the Earth, by its name or by its geographical location.
http://purl.obolibrary.org/obo/IDO_0000586	Infection	http://purl.obolibrary.org/obo/DOID_4	Disease		A part of an extended organism that itself has as part a population of one or more infectious agents and that (1) exists as a result of processes initiated by members of the infectious agent population and is (2) clinically abnormal in virtue of the presence of this infectious agent population, or (3) has a disposition to bring clinical abnormality to immunocompetent organisms of the same Species as the host (the organism corresponding to the extended organism) through transmission of a member or offspring of a member of the infectious agent population.
http://purl.obolibrary.org/obo/OBI_0000185	Imaging Assay	http://purl.obolibrary.org/obo/SCDO_0000082	Diagnostic Technique, Method, Test or Assay		An assay that produces a picture of an entity.
http://purl.obolibrary.org/obo/OBI_0000626	DNA Sequencing	http://purl.obolibrary.org/obo/SCDO_0000448	Genetic Technique		A sequencing process which uses deoxyribonucleic acid as input and results in a the creation of DNA sequence information artifact using a DNA sequencer instrument.
http://purl.obolibrary.org/obo/OBI_0000925	Infectious Agent	http://purl.obolibrary.org/obo/SCDO_0000435	Environmental Disease Modifier		A material entity bearing the disposition to infect an organism
http://purl.obolibrary.org/obo/OBI_0000990	Electron Microscope	http://purl.obolibrary.org/obo/OBI_0400169	Microscope		A microscope that produces an image of an object by targeting it with an electron beam.
http://purl.obolibrary.org/obo/OBI_0001098	Ultrasound Machine	http://purl.obolibrary.org/obo/SCDO_0000376	Diagnostic Device		A device that is used to visualize subcutaneous body structures including tendons, muscles, joints, vessels and internal organs.
http://purl.obolibrary.org/obo/OBI_0001138	X-Ray Machine	http://purl.obolibrary.org/obo/SCDO_0000376	Diagnostic Device		A device that is used to generate X-rays.
http://purl.obolibrary.org/obo/OBI_0200198	Tandem Mass Spectrometry	http://purl.obolibrary.org/obo/SCDO_0000216	Chemical Assay		A data transformation that uses two or more analyzers separated by a region in which ions can be induced to fragment by transfer of energy (frequently by collision with other molecules).
http://purl.obolibrary.org/obo/OBI_0400115	Spectrophotometer	http://purl.obolibrary.org/obo/SCDO_0000376	Diagnostic Device		A spectrophotometer is an instrument that measures the intensity of light as a function of the color, or more specifically, the wavelength of light, transmitted by a substance.
http://purl.obolibrary.org/obo/OBI_0400169	Microscope	http://purl.obolibrary.org/obo/SCDO_0000376	Diagnostic Device		A microscope is an instrument which magnifies the view on objects (too small to be viewed by the naked eye) under increased resolution. A microscope can be an optical instrument but also and electronic instrument. There are various kind of optical microscopes, e.g confocal microscope, epifluoresence microscope).
http://purl.obolibrary.org/obo/OBI_1110053	Cancer	http://purl.obolibrary.org/obo/SCDO_0000267	Comorbid Disease		A disease characterized by abnormal and uncontrolled cell division.
http://purl.obolibrary.org/obo/OGMS_0000023	Phenotype	http://purl.obolibrary.org/obo/SCDO_0001000	SCDO		A (combination of) quality(ies) of an organism determined by the interaction of its genetic make-up and environment that differentiates specific instances of a species from other instances of the same species.
http://purl.obolibrary.org/obo/UO_0000001	Length Unit	http://purl.obolibrary.org/obo/UO_0000000	Unit of Measurement		A unit which is a standard measure of the distance between two points.
http://purl.obolibrary.org/obo/UO_0000002	Mass Unit	http://purl.obolibrary.org/obo/UO_0000000	Unit of Measurement		A unit which is a standard measure of the amount of matter/energy of a physical object.
http://purl.obolibrary.org/obo/UO_0000005	Temperature Unit	http://purl.obolibrary.org/obo/UO_0000000	Unit of Measurement		A unit which is a standard measure of the average kinetic energy of the particles in a sample of matter.
http://purl.obolibrary.org/obo/UO_0000009	Kilogram	http://purl.obolibrary.org/obo/UO_0000002	Mass Unit		A mass unit which is equal to the mass of the International Prototype Kilogram kept by the BIPM at Svres, France.
http://purl.obolibrary.org/obo/UO_0000015	Centimeter	http://purl.obolibrary.org/obo/UO_0000001	Length Unit		A length unit which is equal to one hundredth of a meter or 10^[-2] m.
http://purl.obolibrary.org/obo/UO_0000025	pg	http://purl.obolibrary.org/obo/UO_0000002	Mass Unit		A mass unit which is equal to 10^[-12] g.
http://purl.obolibrary.org/obo/UO_0000051	Concentration Unit	http://purl.obolibrary.org/obo/UO_0000000	Unit of Measurement		A unit which represents a standard measurement of how much of a given substance there is mixed with another substance.
http://purl.obolibrary.org/obo/UO_0000095	Volume Unit	http://purl.obolibrary.org/obo/UO_0000000	Unit of Measurement		A unit which is a standard measure of the amount of space occupied by any substance, whether solid, liquid, or gas.
http://purl.obolibrary.org/obo/UO_0000109	Pressure Unit	http://purl.obolibrary.org/obo/UO_0000000	Unit of Measurement		A unit which is a standard measure of the force applied to a given area.
http://purl.obolibrary.org/obo/UO_0000280	Rate Unit	http://purl.obolibrary.org/obo/UO_0000000	Unit of Measurement		A unit which represents a standard measurement occurrence of a process per unit time.
http://purl.obolibrary.org/obo/VO_0000001	Vaccine	http://purl.obolibrary.org/obo/SCDO_0000930	Infection Prophylaxis		A vaccine is a processed material with the function that when administered, it prevents or ameliorates a disorder in a target organism by inducing or modifying adaptive immune responses specific to the antigens in the vaccine.
http://purl.obolibrary.org/obo/DRON_00017565	Xylometazoline	http://purl.obolibrary.org/obo/SCDO_0000791	Nasal Decongestants		A nasal vasoconstricting decongestant drug which acts by binding to the same receptors as adrenaline. It is applied as a spray or as drops into the nose to ease inflammation and congestion of the nasal passageways. It binds alpha-adrenergic receptors to activate the adrenal system which causes systemic vasoconstriction, thereby easing nasal congestion.
http://purl.obolibrary.org/obo/NCIT_C25191	Person Name	http://purl.obolibrary.org/obo/NCIT_C19332	Personal Attribute		A word or group of words indicating the identity of a person usually consisting of a first (personal) name and a last (family) name with an optional middle name. In some cultural traditions the family name comes first.
http://purl.obolibrary.org/obo/NCIT_C25460	Consent	http://purl.obolibrary.org/obo/NCIT_C19332	Personal Attribute		Permission to do something.
http://purl.obolibrary.org/obo/NCIT_C70817	Study Protocol	http://purl.obolibrary.org/obo/SCDO_0300005	Research Characteristics		The formal plan of an experiment or research activity, including the objective, rationale, design, materials and methods for the conduct of the study; intervention description, and method of data analysis.
http://purl.obolibrary.org/obo/NCIT_C74096	Voluntary	http://purl.obolibrary.org/obo/SCDO_0300005	Research Characteristics		Of your own free will or design; not forced or compelled; controlled by individual volition.
http://purl.obolibrary.org/obo/NCIT_C75434	Hemoglobin Subunit Alpha	http://purl.obolibrary.org/obo/SCDO_1000105	Alpha-Globin Family Members		Hemoglobin subunit alpha (142 aa, ~15 kDa) is encoded by both the human HBA1 and human HBA2 genes. This protein plays a role in the distribution of oxygen from the lungs to other organs and tissues.
http://purl.obolibrary.org/obo/NCIT_C75583	Slit-Lamp Examination	http://purl.obolibrary.org/obo/NCIT_C38060	Eye Examination		Examination of the anterior segment of the eye using a medical instrument called a slit lamp.
http://purl.obolibrary.org/obo/NCIT_65495	Duloxetine	http://purl.obolibrary.org/obo/CHEBI_23888	Drug		A drug used to treat depression and peripheral neuropathy (pain, numbness, tingling, burning, or weakness in the hands or feet) that can occur with diabetes.
http://purl.obolibrary.org/obo/SCDO_0000006	Ability to Carry Out Activities of Daily Living	http://purl.obolibrary.org/obo/SCDO_0000900	Physical Functioning		The performance of the basic activities of self care, such as dressing, ambulation, or eating.
http://purl.obolibrary.org/obo/SCDO_0000007	Abnormal Hemoglobin in SCD	http://purl.obolibrary.org/obo/SCDO_1000060	SCD Molecular Phenotype		A structurally abnormal hemoglobin that occurs in one or more forms of Sickle Cell Disease (SCD).
http://purl.obolibrary.org/obo/SCDO_0000008	deprecated Abnormality of Erythrocytes	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		Abnormality in structure and function of the Red Blood Cell.
http://purl.obolibrary.org/obo/SCDO_0000010	Acetaminophen	http://purl.obolibrary.org/obo/SCDO_0000809	Non Opioid		Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
http://purl.obolibrary.org/obo/SCDO_0000016	Acute Complications of Sickle Cell Disease	http://purl.obolibrary.org/obo/NCIT_C2959	Complication		A condition that co-exists or follows from sickle cell disease and that has a severe and rapid onset of symptoms with short duration.
http://purl.obolibrary.org/obo/SCDO_0000018	Acute Non-Specific Wheezing Episode	http://purl.obolibrary.org/obo/SCDO_1000000	Acute Phenotype		An acute onset of wheezing in a person with SCD who has no co-morbid asthma.
http://purl.obolibrary.org/obo/SCDO_0000019	Acute Sickle Cell Pain Management	http://purl.obolibrary.org/obo/SCDO_0001052	Sickle Cell Pain Management		Sickle cell pain management that aims to heal the acute process.
http://purl.obolibrary.org/obo/SCDO_0000021	Acute Upper Respiratory Tract Infection	http://purl.obolibrary.org/obo/IDO_0000586	Infection		An acute respiratory illness with no lower respiratory tract signs or infiiltrate on chest radiograph.
http://purl.obolibrary.org/obo/SCDO_0000026	Adult Migraine Questionnaire	http://purl.obolibrary.org/obo/SCDO_0000760	Migraine Questionnaire		A 20-item questionnaire that assesses the frequency of severe headaches, the level of pain, whether the person is taking medications, and associated complications such as nausea.
http://purl.obolibrary.org/obo/SCDO_0000028	Adverse Drug Event	http://purl.obolibrary.org/obo/SCDO_1000093	Adverse Event (AE)		An adverse event that occurs after a drug administration.
http://purl.obolibrary.org/obo/SCDO_0000029	Agarose Gel Electrophoresis	http://purl.obolibrary.org/obo/SCDO_0000424	Electrophoresis		Electrophoresis in which agar or agarose gel is used as the diffusion medium.
http://purl.obolibrary.org/obo/SCDO_0000032	Agenesis of Corpus Callosum	http://purl.obolibrary.org/obo/HP_0002060	Abnormality of the Cerebrum		A rare congenital disorder characterized by a partial or complete absence (agenesis) of an area of the brain that connects the two cerebral hemispheres. It can be the result of a failure in any one of the multiple steps of callosal development including cellular proliferation and migration, axonal growth or glial patterning at the midline.
http://purl.obolibrary.org/obo/SCDO_0000034	Alanine Aminotransferase Blood Test	http://purl.obolibrary.org/obo/NCIT_C74954	Liver Function Test		A quantitative measurement of alanine aminotransferase present in a blood sample.
http://purl.obolibrary.org/obo/SCDO_0000037	Albuminuria	http://purl.obolibrary.org/obo/SCDO_0000932	Proteinuria		Increased concentration of albumin in the urine; more than 30mg in 24hours or urine albumin creatinine ratio (ACR) >3 mg/mmol.
http://purl.obolibrary.org/obo/SCDO_0000038	Alcohol - Lifetime Use	http://purl.obolibrary.org/obo/NCIT_C81229	Alcohol Use History		An indication of whether the respondent has ever consumed any alcoholic beverage during his or her entire life.
http://purl.obolibrary.org/obo/SCDO_0000042	Alpha Thalassemia	http://purl.obolibrary.org/obo/NCIT_C35069	Thalassemia		A disorder characterized by reduced synthesis of the alpha chains of hemoglobin. The severity of this condition can vary from mild anemia to death, depending on the number of genes deleted. A hemoglobinopathy with two clinically significant forms: hemoglobin Bart hydrops fetalis (deletion of all 4 alpha-globin genes; --/--) which is severe and often results in neonatal death; and hemoglobin H disease (most commonly caused by deletion of 3 alpha-globin genes; --/-alpha) which results in hemolytic anemia, splenomegaly and bone changes.
http://purl.obolibrary.org/obo/SCDO_0000046	Alpha-Globin Locus	http://purl.obolibrary.org/obo/SCDO_0000456	Globin Locus		A region of chromosome 16 that includes five functional genes and two pseudogenes. The order of genes is: 5' - zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 -alpha-1 - theta1 - 3'. It is responsible for the creation of the alpha parts (roughly half) of the oxygen transport protein Hemoglobin.
http://purl.obolibrary.org/obo/SCDO_0000049	Analgesia	http://purl.obolibrary.org/obo/SCDO_0001133	Symptomatic Therapeutics		Methods of pain relief that may be used with or in place of analgesics.
http://purl.obolibrary.org/obo/SCDO_0000050	Analgesic	http://purl.obolibrary.org/obo/CHEBI_23888	Drug		A compound capable of relieving pain without the loss of consciousness.
http://purl.obolibrary.org/obo/SCDO_0000053	Anesthetic Complication AE	http://purl.obolibrary.org/obo/SCDO_0000028	Adverse Drug Event		An adverse drug event that results in unexpected and unwanted events due to anesthetic drug treatment.
http://purl.obolibrary.org/obo/SCDO_0000054	Angioid Streaks	http://purl.obolibrary.org/obo/HP_0000478	Abnormality of the Eye		Grayish, brown, or dark red streaks caused by cracks in Bruch's membrane that are histologically characterized by calcium deposition. Angioid streaks are most characteristic of sickle cell anemia and can occur to a lesser extent in other sickle cell syndromes, but not in sickle cell trait.
http://purl.obolibrary.org/obo/SCDO_0000055	Angiotensin-Converting Enzyme Inhibitors	http://purl.obolibrary.org/obo/SCDO_0000067	Antihypertensive Agents		A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.
http://purl.obolibrary.org/obo/SCDO_0000056	Annual Family Income	http://purl.obolibrary.org/obo/NCIT_C16495	Demographic Factor		The respondent's total family income from the last calendar year.
http://purl.obolibrary.org/obo/SCDO_0000057	Anti-Inflammatory Agent	http://purl.obolibrary.org/obo/SCDO_0000809	Non Opioid		Substance that reduces or suppresses inflammation.
http://purl.obolibrary.org/obo/SCDO_0000067	Antihypertensive Agents	http://purl.obolibrary.org/obo/CHEBI_23888	Drug		Used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. Among the antihypertensive agents are diuretics; (especially diuretics, thiazide); adrenergic aeta-antagonists; adrenergic alpha-antagonistics; angiotensin-converting enzyme inhibitors; calcium channel blockers; ganglionic blockers; and vasodilator agents.
http://purl.obolibrary.org/obo/SCDO_0000069	APOL1	http://purl.obolibrary.org/obo/SCDO_0000810	Non-Globin Gene		This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Variants in the APOL1 gene can influence susceptibility to end-stage renal disease and Trypanosomiasis (African Sleeping Sickness).
http://purl.obolibrary.org/obo/SCDO_0000070	Aquatic Rehabilitation	http://purl.obolibrary.org/obo/SCDO_0000978	Rehabilitation		Exercises performed in or underwater for conditioning or rehabilitation (e.g., in injured athletes or patients with joint diseases).
http://purl.obolibrary.org/obo/SCDO_0000071	Arterial Blood Gas Test	http://purl.obolibrary.org/obo/SCDO_0000133	Blood Test		A hematology assay that measures the acidity (pH) and the levels of oxygen and carbon dioxide in the blood from an artery. This test is used to check how well the lungs are able to move oxygen into the blood and remove carbon dioxide from the blood.
http://purl.obolibrary.org/obo/SCDO_0000078	deprecated ASCQ-Me Score	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		The score obtained from the Adult Sickle Cell Quality-of-Life Measurement Information System (ASCQ-Me).
http://purl.obolibrary.org/obo/SCDO_0000079	Aspartate Aminotransferase Blood Test	http://purl.obolibrary.org/obo/NCIT_C74954	Liver Function Test		A bioassay to measure levels of aspartate aminotransferase (AST), which is released into the blood following tissue damage.
http://purl.obolibrary.org/obo/SCDO_0000080	Aspartate Aminotransferase Level	http://purl.obolibrary.org/obo/CMO_0000023	Blood Chemistry Measurement		The amount of aspartate  aminotransferase present in a specified volume of blood.
http://purl.obolibrary.org/obo/SCDO_0000081	ASCQ-Me - Quality of Care in SCD	http://purl.obolibrary.org/obo/SCDO_0000947	Quality of Care Measure		A set of 27 questions administered to adults with sickle cell disease (SCD) to determine the quality of care that they have received from health care providers.
http://purl.obolibrary.org/obo/SCDO_0000082	Diagnostic Technique, Method, Test or Assay	http://purl.obolibrary.org/obo/SCDO_1000032	Diagnostic Tool		A planned process with the objective of producing diagnostic information about the material entity that is the evaluant, by physically examining it or its proxies.
http://purl.obolibrary.org/obo/SCDO_0000084	Assessment of Short-Axis Cardiac Function by MRI	http://purl.obolibrary.org/obo/NCIT_C16809	Magnetic Resonance Imaging		This measure is a magnetic resonance imaging (MRI) method of capturing an individual's heart performance, and is considered the gold standard for capturing ventricular volumes and mass. It is used to detect cardiac abnormalities, such as cardiomyopathies, myocardial fibrosis, and infarction.
http://purl.obolibrary.org/obo/SCDO_0000086	Asthma	http://purl.obolibrary.org/obo/SCDO_0000954	Quality of Life Related SCD Symptoms and Complications		A form of bronchial disorder with three distinct components: airway hyper-responsiveness, airway inflammation, and intermittent airway obstruction. It is characterized by spasmodic contraction of airway smooth muscle, wheezing and dyspnea.
http://purl.obolibrary.org/obo/SCDO_0000088	Atopic Dermatitis	http://purl.obolibrary.org/obo/HP_0011123	Skin Inflammation		A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.
http://purl.obolibrary.org/obo/SCDO_0000094	BCL11A	http://purl.obolibrary.org/obo/SCDO_0000810	Non-Globin Gene		This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.
http://purl.obolibrary.org/obo/SCDO_0000102	Beck Anxiety Inventory (BAI)	http://purl.obolibrary.org/obo/SCDO_1000297	Quality of Life and Care Diagnostic Instrument		The BAI is the most widely used instument for measuring anxiety. It consists of 21 items to assess how bothersome a symptom of anxiety has been for the subject over the past month. Scoring the BAI is based on a 0-3 point scale with higher scores indicating severity.
http://purl.obolibrary.org/obo/SCDO_0000104	Behavior Rating Inventory of Executive Function	http://purl.obolibrary.org/obo/SCDO_0001304	Executive Function Measure		The Behavior Rating Inventory of Executive Function (BRIEF) is a detailed questionnaire designed to assess executive function behaviors of children and adolescents in the school and home environments. The BRIEF is completed by parents and teachers.
http://purl.obolibrary.org/obo/SCDO_0000106	Behaviour	http://purl.obolibrary.org/obo/SCDO_0000746	Mental Health		The actions or reactions of a person in response to a situation or stimuli.
http://purl.obolibrary.org/obo/SCDO_0000108	Beliefs About Remedies and Treatment	http://purl.obolibrary.org/obo/SCDO_0000488	Health Beliefs		Personal or collective understanding of what can remedy or treat illness.
http://purl.obolibrary.org/obo/SCDO_0000110	Beta Minus Thalassemia	http://purl.obolibrary.org/obo/SCDO_0000111	Beta Thalassemia		A beta-thalassemia caused by the reduced (beta-) synthesis of the beta globin chains of the hemoglobin (Hb) tetramer.
http://purl.obolibrary.org/obo/SCDO_0000111	Beta Thalassemia	http://purl.obolibrary.org/obo/NCIT_C35069	Thalassemia		A hemoglobinopathy characterized by the reduced (beta plus) or absent (beta zero) synthesis of the beta globin chains of hemoglobin, resulting in variable outcomes ranging from severe anemia to clinically asymptomatic individuals.
http://purl.obolibrary.org/obo/SCDO_0000112	Beta Thalassemia Intermedia	http://purl.obolibrary.org/obo/SCDO_0000251	Clinical Phenotype of Beta Thalassemia		A homozygous (B+/B+) or compound heterozygous (B0/B+) form of beta-thalassemia characterized by mild to moderate anemia which does not or only occasionally requires transfusion.
http://purl.obolibrary.org/obo/SCDO_0000113	Beta Thalassemia Major	http://purl.obolibrary.org/obo/SCDO_0000251	Clinical Phenotype of Beta Thalassemia		A severe early-onset form of beta thalassemia characterized by severe anemia requiring regular red blood cell transfusions.
http://purl.obolibrary.org/obo/SCDO_0000117	Beta-Globin Haplotype	http://purl.obolibrary.org/obo/NCIT_C63547	Haplotype		Defined arrays of polymorphic gene sites that are inherited together across the genetic vicinity of the beta-globin gene or gene cluster on chromosome 11.
http://purl.obolibrary.org/obo/SCDO_0000120	Biochemical Assay	http://purl.obolibrary.org/obo/SCDO_0000216	Chemical Assay		An analytical in vitro procedure used to detect, quantify and/or study the binding or activity of a biological molecule, such as an enzyme.
http://purl.obolibrary.org/obo/SCDO_0000123	Birthplace	http://purl.obolibrary.org/obo/NCIT_C16495	Demographic Factor		The country in which the respondent was born.
http://purl.obolibrary.org/obo/SCDO_0000124	Birthplace of Biological Father	http://purl.obolibrary.org/obo/SCDO_0000129	Birthplace of Parents		The country in which the respondent's biological father was born.
http://purl.obolibrary.org/obo/SCDO_0000125	Birthplace of Biological Mother	http://purl.obolibrary.org/obo/SCDO_0000129	Birthplace of Parents		The country in which the respondent's biological mother was born.
http://purl.obolibrary.org/obo/SCDO_0000126	Birthplace of Grandparents	http://purl.obolibrary.org/obo/NCIT_C16495	Demographic Factor		The country or countires in which the respondent's biological grandparents were born.
http://purl.obolibrary.org/obo/SCDO_0000127	Birthplace of Maternal Grandfather	http://purl.obolibrary.org/obo/SCDO_0000126	Birthplace of Grandparents		The country in which the respondent's biological maternal (on the mother's side of the family) grandfather was born.
http://purl.obolibrary.org/obo/SCDO_0000128	Birthplace of Maternal Grandmother	http://purl.obolibrary.org/obo/SCDO_0000126	Birthplace of Grandparents		The country in which the respondent's biological maternal (on the mother's side of the family) grandmother was born.
http://purl.obolibrary.org/obo/SCDO_0000129	Birthplace of Parents	http://purl.obolibrary.org/obo/NCIT_C16495	Demographic Factor		The country or countires in which the respondent's biological parents were born.
http://purl.obolibrary.org/obo/SCDO_0000130	Birthplace of Paternal Grandfather	http://purl.obolibrary.org/obo/SCDO_0000126	Birthplace of Grandparents		The country in which the respondent's biological paternal (on the father's side of the family) grandfather was born.
http://purl.obolibrary.org/obo/SCDO_0000131	Birthplace of Paternal Grandmother	http://purl.obolibrary.org/obo/SCDO_0000126	Birthplace of Grandparents		The country in which the respondent's biological paternal (on the father's side of the family) grandmother was born.
http://purl.obolibrary.org/obo/SCDO_0000132	Black Sunburst Lesion	http://purl.obolibrary.org/obo/HP_0000478	Abnormality of the Eye		Black lesions in the retina that form at the border of perfused and nonperfused retina that are caused by the migration of hyperplastic retinal pigment epithelial cells into sensory retina. The sensory retina surrounding the lesion is atrophic.
http://purl.obolibrary.org/obo/SCDO_0000133	Blood Test	http://purl.obolibrary.org/obo/SCDO_0000902	Physiological Assay		Test used in the analysis of the hemic system.
http://purl.obolibrary.org/obo/SCDO_0000138	Blood Component Transfusion	http://purl.obolibrary.org/obo/SCDO_0000147	Blood Transfusion		The transfer of blood components such as erythrocytes, leukocytes, platelets, and plasma from a donor to a recipient or back to the donor. This process differs from the procedures undertaken in plasmapheresis and types of cytapheresis; (plateletpheresis and leukapheresis) where, following the removal of plasma or the specific cell components, the remainder is transfused back to the donor.
http://purl.obolibrary.org/obo/SCDO_0000139	Blood Culture	http://purl.obolibrary.org/obo/SCDO_0000133	Blood Test		Test to determine the presence of blood infection (e.g. sepsis; bacteremia).
http://purl.obolibrary.org/obo/SCDO_0000147	Blood Transfusion	http://purl.obolibrary.org/obo/SCDO_0001133	Symptomatic Therapeutics		The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)
http://purl.obolibrary.org/obo/SCDO_0000149	Body Height	http://purl.obolibrary.org/obo/CMO_0000011	Whole Body Morphological Measurement		The distance from the sole to the crown of the head with body standing on a flat surface and fully extended.
http://purl.obolibrary.org/obo/SCDO_0000152	Body Weight	http://purl.obolibrary.org/obo/CMO_0000011	Whole Body Morphological Measurement		The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
http://purl.obolibrary.org/obo/SCDO_0000155	deprecated-Bone Sclerosis	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		An abnormal hardening or increased density of bone tissue.
http://purl.obolibrary.org/obo/SCDO_0000156	Brachial Artery Ultrasound Imaging	http://purl.obolibrary.org/obo/SCDO_0001228	Endothelial Function Test		A noninvasive method to assess the endothelial dysfunction in the brachial artery.
http://purl.obolibrary.org/obo/SCDO_0000161	Brain Electrical Activity	http://purl.obolibrary.org/obo/SCDO_0000728	Diagnostic Measurement		Voltages between parts of the brain that are detectable with an electroencephalograph.
http://purl.obolibrary.org/obo/SCDO_0000162	Breakthrough Pain	http://purl.obolibrary.org/obo/SCDO_0000233	Chronic Sickle Cell Pain		An episode of severe pain that occurs with rapid onset even when pain-control medication is being used. Breakthrough pain can occur spontaneously or in relation to a specific activity, and can last from a few seconds to a few hours.
http://purl.obolibrary.org/obo/SCDO_0000163	Brief Illness Perception Questionnaire (B-IPQ)	http://purl.obolibrary.org/obo/SCDO_0000951	Quality of Life and Care Measure		The Brief IPQ has 9 items, 8 new items from the IPQ plus a causal question. All of the items except the causal question are rated using a 0-to-10-response scale. Five of the items assess Cognitive Illness Representations: Consequences (Item 1), Timeline (Item 2), Personal Control (Item 3), Treatment Control (Item 4), and Identity (Item 5). Two of the items assess Emotional Representations: Concern (Item 6) and Emotions (Item 8). One item assesses Illness Comprehensibility (Item 7). Assessment of the Causal Representation is by an open-ended response item adapted, which asks patients to list the three most important causal factors in their illness (Item 9). Responses to the causal item can be grouped into categories such as stress, lifestyle, hereditary, etc, determined by the particular illness studied, and categorical analysis can then be performed.
http://purl.obolibrary.org/obo/SCDO_0000164	Brief RCOPE	http://purl.obolibrary.org/obo/SCDO_0000953	Quality of Life Measure		Brief RCOPE is a 14-item instrument that measures religious coping with major life stressors. Responses on the Brief RCOPE indicate the frequency with which participants have used R/S coping behaviors on a Likert scale of 1 (not at all) to 4 (a great deal.) The scale has been used to examine positive and negative religious coping, including in teens with SCD.
http://purl.obolibrary.org/obo/SCDO_0000165	Bronchodilator Responsiveness	http://purl.obolibrary.org/obo/CMO_0000094	Respiratory System Measurement		The improvement of forced expiratory volume in 1 second (FEV1) after inhalation of beta2-agonists and is typically measured as the change in airflow after the administration of short-acting beta2-adrenergic agonists (SABAs).
http://purl.obolibrary.org/obo/SCDO_0000166	Bronchodilator Responsiveness Test	http://purl.obolibrary.org/obo/SCDO_0000942	Pulmonary Function Test		A test to assess an individual's change in pulmonary function in response to inhaled bronchodilator medications.
http://purl.obolibrary.org/obo/SCDO_0000182	Capillary Electrophoresis	http://purl.obolibrary.org/obo/SCDO_0000424	Electrophoresis		A highly-sensitive (in the picomolar range, which is 10,000-fold more sensitive than conventional electrophoresis) and efficient technique that allows separation of proteins; nucleic acids; and carbohydrates. (Segen, Dictionary of Modern Medicine, 1992)
http://purl.obolibrary.org/obo/SCDO_0000183	Cardioscope	http://purl.obolibrary.org/obo/SCDO_0000376	Diagnostic Device		An instrument which, by means of a cathode-ray oscillograph, projects an electrocardiographic record on a luminous screen.
http://purl.obolibrary.org/obo/SCDO_0000187	deprecated Cardiovascular System	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		'Anatomical system that has as its parts the heart and blood vessels. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000188	obsolete Case Reports	http://purl.obolibrary.org/obo/SCDO_0000941	obsolete Publication Type		'Clinical presentations that may be followed by evaluative studies that eventually lead to a diagnosis. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000189	Case-Control Studies	http://purl.obolibrary.org/obo/SCDO_0000437	Epidemiologic Studies		Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
http://purl.obolibrary.org/obo/SCDO_0000190	Catheter	http://purl.obolibrary.org/obo/SCDO_0001150	Therapeutic Device		A flexible, tubular device that is used to carry fluids into or from a blood vessel, hollow organ, or body cavity.
http://purl.obolibrary.org/obo/SCDO_0000191	Causal Adverse Drug Event	http://purl.obolibrary.org/obo/SCDO_0000028	Adverse Drug Event		A drug adverse event that is caused by a drug administration. Here a causal effect is established between the drug administration and the adverse event.
http://purl.obolibrary.org/obo/SCDO_0000192	Causal Adverse Drug Event Due to Drug-Drug Interaction	http://purl.obolibrary.org/obo/SCDO_0000191	Causal Adverse Drug Event		A causal adverse drug event that is induced by a drug-drug interaction.
http://purl.obolibrary.org/obo/SCDO_0000193	Causal Adverse Drug Event Due to Food-Drug Interaction	http://purl.obolibrary.org/obo/SCDO_0000191	Causal Adverse Drug Event		A causal adverse drug event that is induced by a food-drug interaction.
http://purl.obolibrary.org/obo/SCDO_0000198	Cell Free Hemoglobin Blood Test	http://purl.obolibrary.org/obo/SCDO_0000133	Blood Test		The determination of the amount of free hemoglobin present in a sample.
http://purl.obolibrary.org/obo/SCDO_0000199	Cell Free Hemoglobin Level	http://purl.obolibrary.org/obo/CMO_0000023	Blood Chemistry Measurement		The level of hemoglobin external to erythrocytes in a biological specimen.
http://purl.obolibrary.org/obo/SCDO_0000206	Cerebral Collateral Flow	http://purl.obolibrary.org/obo/SCDO_0000213	Cerebrovascular Hemodynamics		Cerebral collateral circulation is a subsidiary vascular network which is dynamically recruited after arterial occlusion and may provide residual blood flow to ischemic areas.
http://purl.obolibrary.org/obo/SCDO_0000208	Cerebral Function Assay	http://purl.obolibrary.org/obo/SCDO_0000902	Physiological Assay		A test of how well the cerebrum is functioning.
http://purl.obolibrary.org/obo/SCDO_0000213	Cerebrovascular Hemodynamics	http://purl.obolibrary.org/obo/CMO_0000195	Blood Flow Measurement		The movement and the forces involved in the movement of the blood through the blood vessels in the brain.
http://purl.obolibrary.org/obo/SCDO_0000216	Chemical Assay	http://purl.obolibrary.org/obo/SCDO_0000082	Diagnostic Technique, Method, Test or Assay		The analysis of a sample material, called an analyte, using a set of chemical procedures.
http://purl.obolibrary.org/obo/SCDO_0000217	Chest X-Ray	http://purl.obolibrary.org/obo/SCDO_0000963	Radiography		A medical imaging assessment of the chest wall, airways, lungs, pulmonary vessels, heart, mediastinum, and pleura.
http://purl.obolibrary.org/obo/SCDO_0000218	Child Health Questionnaire (CHQ)	http://purl.obolibrary.org/obo/SCDO_0000953	Quality of Life Measure		The Child Health Questionnaire (CHQ) is a family of general quality of life surveys that measures 14 unique physical and psychosocial concepts. The parent form is available in 2 lengths - the CHQ-PF50 and the CHQ-PF28. The child self-reported version of the CHQ consists of 87 items (CHQ-CF87).
http://purl.obolibrary.org/obo/SCDO_0000219	Child-Reported Parental Education Attainment	http://purl.obolibrary.org/obo/SCDO_0000305	Current Educational Attainment		A parent's highest level of education obtained, as reported by the child.
http://purl.obolibrary.org/obo/SCDO_0000220	Children's Depression Inventory 2 (CDI 2)	http://purl.obolibrary.org/obo/SCDO_0000953	Quality of Life Measure		The CDI-2 is a 27-item self-report scale that helps to assess cognitive, affective and behavioral signs of depression in children and adolescents. Each item is scored on a scale from 0 to 2.
http://purl.obolibrary.org/obo/SCDO_0000221	Children's Health Locus of Control Scale (CHLC)	http://purl.obolibrary.org/obo/SCDO_0000951	Quality of Life and Care Measure		A measure that seeks to determine the extent to which children and adolescents believe their own health-related behaviors will influence their health. It is a 20 item scale that contains 3 additional practice items and is a yes or no format. It contains 3 factors: belief in internality, belief in powerful others and belief in chance. There is a shorter 9-item version of the scale which is comparable to the full version and adapted for use in Egyptian children.
http://purl.obolibrary.org/obo/SCDO_0000222	Cholecystectomy	http://purl.obolibrary.org/obo/SCDO_0001129	Supportive Therapeutics		Surgical removal of the gallbladder.
http://purl.obolibrary.org/obo/SCDO_0000225	Chronic Complications of Sickle Cell Disease	http://purl.obolibrary.org/obo/NCIT_C2959	Complication		A condition that co-exists or follows from sickle cell disease and that has a slow, creeping onset, slow progress and long continuance of disease manifestations.
http://purl.obolibrary.org/obo/SCDO_0000226	Chronic Kidney Disease	http://purl.obolibrary.org/obo/HP_0000084	Kidney Failure		Chronic kidney disease (CKD) is defined as either having a glomerular filtration rate (GFR) of <60 mL/min/1.73 mL for >3 months with or without kidney damage or having evidence of kidney damage for 3 months, with or without decreased GFR.
http://purl.obolibrary.org/obo/SCDO_0000227	deprecated-Chronic Kidney Injury	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		Is a long-term condition where the kidneys don't work as well as they should.
http://purl.obolibrary.org/obo/SCDO_0000228	Chronic Neuropathic Pain	http://purl.obolibrary.org/obo/SCDO_0000233	Chronic Sickle Cell Pain		Chronic pain caused by damage to nerve fibers. It is usually associated with tissue injury. This pain is usually described as burning, numb, tingling, lancinating, shooting, or paroxysmal in nature and is associated with a sensation of pins and needles. Its severity is also enhanced by exposure to either cold or heat.
http://purl.obolibrary.org/obo/SCDO_0000229	Chronic Pain in a Specific Tissue or Organ	http://purl.obolibrary.org/obo/SCDO_0000233	Chronic Sickle Cell Pain		This pain occurs in a specific tissue or organ and is usually described as constant and deep, nagging, and achy in nature.
http://purl.obolibrary.org/obo/SCDO_0000230	Chronic Pain often Unclear Etiology	http://purl.obolibrary.org/obo/SCDO_0000233	Chronic Sickle Cell Pain		The only complaint is the patient's self-report of pain that does not go away.
http://purl.obolibrary.org/obo/SCDO_0000232	Chronic Restrictive Lung Disease	http://purl.obolibrary.org/obo/SCDO_0001334	Chronic Phenotype		Restrictive lung disease is a category of extrapulmonary, pleural, or parenchymal respiratory diseases that restrict lung expansion, resulting in a decreased lung volume, an increased work of breathing, and inadequate ventilation and/or oxygenation. Pulmonary function test demonstrates a decrease in the forced vital capacity.
http://purl.obolibrary.org/obo/SCDO_0000233	Chronic Sickle Cell Pain	http://purl.obolibrary.org/obo/HP_0012532	Chronic Pain		Persistent pain in sickle cell disease. In sickle cell disease, persistent pain (pain that has lasted longer than 3 to 6 months) no longer serves as a warning sign. However, the time distinction is arbitrary and the condition may be difficult to distinguish from frequently recurring acute pain. Chronic pain may occur with objective signs of avascular necrosis, arthropathy, arthritis, leg ulcers or vertebral body collapse, or without objective signs, due to neuroplasticity of the peripheral nervous system.
http://purl.obolibrary.org/obo/SCDO_0000234	Chronic Sickle Cell Pain Management	http://purl.obolibrary.org/obo/SCDO_0001052	Sickle Cell Pain Management		Sickle cell pain management that aims to restore function and improve the quality of life.
http://purl.obolibrary.org/obo/SCDO_0000235	Cigarette Smoking Status	http://purl.obolibrary.org/obo/NCIT_C29719	Smoking History		An indication of a person's current cigarette use as well as some indication of cigarette smoking history.
http://purl.obolibrary.org/obo/SCDO_0000236	Climate	http://purl.obolibrary.org/obo/SCDO_0000897	Physical Environment		Meteorological conditions, including temperature, precipitation, and wind, that characteristically prevail in a particular region; includes regions of the earth having particular meteorological conditions.
http://purl.obolibrary.org/obo/SCDO_0000245	Clinical Coding	http://purl.obolibrary.org/obo/SCDO_0000738	Medical Records		Process of substituting a symbol or code for a term such as a diagnosis or procedure. (from Slee's Health Care Terms, 3d ed.)
http://purl.obolibrary.org/obo/SCDO_0000246	Clinical Competence	http://purl.obolibrary.org/obo/SCDO_0000948	Quality of Health Care		The capability to perform acceptably those duties directly related to patient care.
http://purl.obolibrary.org/obo/SCDO_0000247	obsolete Clinical Conference	http://purl.obolibrary.org/obo/SCDO_0000941	obsolete Publication Type		'Work that consists of a conference of physicians on their observations of a patient at the bedside, regarding the physical state, laboratory and other diagnostic findings, clinical manifestations, results of current therapy, etc. A clinical conference usually ends with a confirmation or correction of clinical findings by a pathological diagnosis performed by a pathologist. Clinical conference is often referred to as a clinico-pathological conference. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000250	Clinical Neuropathy Assessment	http://purl.obolibrary.org/obo/SCDO_0000898	Physical Examination		A physician administered examination to assess peripheral neuropathy.
http://purl.obolibrary.org/obo/SCDO_0000252	obsolete Clinical Study	http://purl.obolibrary.org/obo/SCDO_0000941	obsolete Publication Type		'A work that reports on the results of a research study to evaluate interventions or exposures on biomedical or health-related outcomes. The two main types of clinical studies are interventional studies (clinical trials) and observational studies. While most clinical studies concern humans, this publication type may be used for clinical veterinary articles meeting the requisites for humans. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000253	Clinical Studies as Topic	http://purl.obolibrary.org/obo/SCDO_0300004	Epidemiologic Study Characteristics		Works about research studies that evaluate interventions or exposures on biomedical or health-related outcomes. The two main types of clinical studies are interventional studies (clinical trials) and observational studies.
http://purl.obolibrary.org/obo/SCDO_0000254	obsolete Clinical Trial	http://purl.obolibrary.org/obo/SCDO_0000252	obsolete Clinical Study		'A work that reports on the results of a clinical study in which participants are assigned to receive one or more interventions so that researchers can evaluate the interventions on biomedical or health-related outcomes. The assignments are determined by the study protocol. Participants may receive diagnostic, therapeutic, or other types of interventions. While most clinical trials concern humans, this publication type may be used for clinical veterinary articles meeting the requisites for humans. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000255	obsolete Clinical Trial, Phase I	http://purl.obolibrary.org/obo/SCDO_0000254	obsolete Clinical Trial		'Work that is the report of a pre-planned, usually controlled, clinical study of the safety and efficacy of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques based on a small number of healthy persons and conducted over the period of about a year in either the United States or a foreign country. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000256	obsolete Clinical Trial, Phase II	http://purl.obolibrary.org/obo/SCDO_0000254	obsolete Clinical Trial		'Work that is a report of a pre-planned, usually controlled, clinical study of the safety and efficacy of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques based on several hundred volunteers, including a limited number of patients, and conducted over a period of about two years in either the United States or a foreign country. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000257	obsolete Clinical Trial, Phase IV	http://purl.obolibrary.org/obo/SCDO_0000254	obsolete Clinical Trial		'Work that is a report of a planned post-marketing study of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques that have been approved for general sale after clinical trials, phases I, II, and III. These studies, conducted in the United States or a foreign country, often garner additional data about the safety and efficacy of a product. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000258	obsolete Clinical Trial, Phase III	http://purl.obolibrary.org/obo/SCDO_0000254	obsolete Clinical Trial		'Work that is a report of a pre-planned, usually controlled, clinical study of the safety and efficacy of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques after phase II trials. A large enough group of patients is studied and closely monitored by physicians for adverse response to long-term exposure, over a period of about three years in either the United States or a foreign country. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000259	Clinical Trials as Topic	http://purl.obolibrary.org/obo/SCDO_0000253	Clinical Studies as Topic		Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
http://purl.obolibrary.org/obo/SCDO_0000262	Cognitive Therapy	http://purl.obolibrary.org/obo/SCDO_0001284	Behaviour Therapy		A direct form of psychotherapy based on the interpretation of situations (cognitive structure of experiences) that determine how an individual feels and behaves. It is based on the premise that cognition, the process of acquiring knowledge and forming beliefs, is a primary determinant of mood and behavior. The therapy uses behavioral and verbal techniques to identify and correct negative thinking that is at the root of the aberrant behavior.
http://purl.obolibrary.org/obo/SCDO_0000263	Cohort Studies	http://purl.obolibrary.org/obo/SCDO_0000437	Epidemiologic Studies		Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
http://purl.obolibrary.org/obo/SCDO_0000265	Coma	http://purl.obolibrary.org/obo/HP_0012638	Abnormal Nervous System Physiology		A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem reticular formation.
http://purl.obolibrary.org/obo/SCDO_0000267	Comorbid Disease	http://purl.obolibrary.org/obo/DOID_4	Disease		A co-existing or additional disease with reference to an initial diagnosis or with reference to the index condition that is the subject of study.
http://purl.obolibrary.org/obo/SCDO_0000268	Comparative Study	http://purl.obolibrary.org/obo/SCDO_0000437	Epidemiologic Studies		Comparison of outcomes, results, responses, etc for different techniques, therapeutic approaches or other inputs.
http://purl.obolibrary.org/obo/SCDO_0000271	Complementary Therapy	http://purl.obolibrary.org/obo/SCDO_0001152	Therapeutics		Therapeutic practices which are not currently considered an integral part of conventional allopathic medical practice. They may lack biomedical explanations but as they become better researched some (physical therapy modalities; diet; acupuncture) become widely accepted whereas others (humors, radium therapy) quietly fade away, yet are important historical footnotes. Therapies are termed as Complementary when used in addition to conventional treatments and as Alternative when used instead of conventional treatment. Year introduced: 2002(1986).
http://purl.obolibrary.org/obo/SCDO_0000272	obsolete Compound Heterozygous Hemoglobinopathy	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		'Compound heterozygosity in medical genetics is the condition of having two heterogeneous recessive alleles at a particular locus that can cause genetic disease in a heterozygous state. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000276	Conjunctival Comma Sign	http://purl.obolibrary.org/obo/HP_0000478	Abnormality of the Eye		Dark red, comma- or corkscrew-shaped vascular fragment that appears to be isolated from neighboring blood vessels in the conjunctiva. Normally benign, this lesion can serve as the first diagnostic sign of sickle cell retinopathy. The conjunctival comma sign results from transient vaso-occlusive processes in the microvasculature of bulbar conjunctiva. It is not seen in sickle trait, but is common in SCD.
http://purl.obolibrary.org/obo/SCDO_0000277	obsolete Consensus Development Conference	http://purl.obolibrary.org/obo/SCDO_0000941	obsolete Publication Type		'A work that consists of summary statements representing the majority and current agreement of physicians, scientists, and other professionals meeting to reach a consensus on a selected subject. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000278	obsolete Consensus Development Conference, NIH	http://purl.obolibrary.org/obo/SCDO_0000277	obsolete Consensus Development Conference		'Work consisting of summary statements, from a conference sponsored by NIH, representing the majority of current opinion of physicians, scientists, and other professionals on a selected subject. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000280	Consumer Assessment of Healthcare Providers and Systems (CAHPS) Health Plan Survey 4.0 Child Medicaid Questionnaire	http://purl.obolibrary.org/obo/SCDO_0000947	Quality of Care Measure		A tool for collecting standardized information on enrollees' experiences with health plans and their services.
http://purl.obolibrary.org/obo/SCDO_0000282	Controlled Pre-Post Studies	http://purl.obolibrary.org/obo/SCDO_0000437	Epidemiologic Studies		A study in which observations are made before and after an intervention, both in a group that receives the intervention and in a control group that does not.
http://purl.obolibrary.org/obo/SCDO_0000283	obsolete Controlled Clinical Trial	http://purl.obolibrary.org/obo/SCDO_0000254	obsolete Clinical Trial		'A work that reports on a clinical trial involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicine, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trial is characterized as a randomized controlled trial. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000284	Controlled Clinical Trials as Topic	http://purl.obolibrary.org/obo/SCDO_0000259	Clinical Trials as Topic		Works about clinical trials involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicines, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trials are characterized as randomized controlled trials as topic.
http://purl.obolibrary.org/obo/SCDO_0000286	Coping Skill	http://purl.obolibrary.org/obo/SCDO_0000746	Mental Health		A state of harmony between internal needs and external demands and the processes used in achieving this condition.
http://purl.obolibrary.org/obo/SCDO_0000287	Coping Strategies Questionnaire revised for Sickle Cell Disease (CSQ-SCD)	http://purl.obolibrary.org/obo/SCDO_0000953	Quality of Life Measure		The CSQ-SCD consists of 78 items, which make up seven scales related to coping with pain in general: Diverting attention, Reinterpreting pain sensations, Calming self-statements, Ignoring pain sensations, Praying and hoping, Catastrophising, and Increasing activity level; together with six scales developed as specifically relevant to sickle cell disease: Fear self-statements, Anger self-statements, Isolation, Taking fluids, Resting, and Heat/cold/massage. Patients rated their use of each response from 0 = never to 6 = always, and scores were averaged to produce a mean for each scale. Two additional aspects were assessed by single items: perceived ability to control pain was rated from 0 = no control to 6 = complete control, and perceived ability to decrease pain was rated from 0 = can't decrease it at all to 6 = can decrease it completely.
http://purl.obolibrary.org/obo/SCDO_0000288	Coping Strategies Questionnaire revised for Sickle Cell Disease Children (CSQ-SCD Children)	http://purl.obolibrary.org/obo/SCDO_0000953	Quality of Life Measure		The CSQ-SCD consists of 78 items, which make up seven scales related to coping with pain in general: Diverting attention, Reinterpreting pain sensations, Calming self-statements, Ignoring pain sensations, Praying and hoping, Catastrophising, and Increasing activity level; together with six scales developed as specifically relevant to sickle cell disease: Fear self-statements, Anger self-statements, Isolation, Taking fluids, Resting, and Heat/cold/massage. Patients rated their use of each response from 0 = never to 6 = always, and scores were averaged to produce a mean for each scale. Two additional aspects were assessed by single items: perceived ability to control pain was rated from 0 = no control to 6 = complete control, and perceived ability to decrease pain was rated from 0 = can't decrease it at all to 6 = can decrease it completely.
http://purl.obolibrary.org/obo/SCDO_0000291	Corticosteroid-Induced Adverse Event	http://purl.obolibrary.org/obo/SCDO_0000191	Causal Adverse Drug Event		A causal adverse drug event that is induced by a corticosteroid.
http://purl.obolibrary.org/obo/SCDO_0000292	Corticosteroid-Induced Vaso-Occlusive Adverse Event	http://purl.obolibrary.org/obo/SCDO_0000291	Corticosteroid-Induced Adverse Event		A corticosteroid-induced adverse event that has the outcome of vaso-occlusion.
http://purl.obolibrary.org/obo/SCDO_0000294	Cost of Illness	http://purl.obolibrary.org/obo/SCDO_0000746	Mental Health		The personal cost of disease which may be economic, social, or psychological. The cost of illness may be reflected in absenteeism, productivity, response to treatment, peace of mind, or quality of life. It differs from health care costs, the societal cost of providing services related to the delivery of health care.
http://purl.obolibrary.org/obo/SCDO_0000295	Cost-Effectiveness of Healthcare	http://purl.obolibrary.org/obo/SCDO_0000495	Health Utility		The extent to which a health intervention can be regarded as providing value for money, based on a cost-effectiveness analysis that compares the costs and health effects of the intervention. This informs decision-makers who have to determine where to allocate limited healthcare resources.
http://purl.obolibrary.org/obo/SCDO_0000296	Creatinine Blood Test	http://purl.obolibrary.org/obo/SCDO_0000676	Kidney Function Test		A bioassay to measure the serum concentration of creatinine, a metabolite of muscle creatine that is filtered out of blood by the kidneys.
http://purl.obolibrary.org/obo/SCDO_0000297	Crisis Intervention	http://purl.obolibrary.org/obo/SCDO_0000940	Psychotherapy		Brief therapeutic approach which is ameliorative rather than curative of acute psychiatric emergencies. Used in contexts such as emergency rooms of psychiatric or general hospitals, or in the home or place of crisis occurrence, this treatment approach focuses on interpersonal and intrapsychic factors and environmental modification. (APA Thesaurus of Psychological Index Terms, 7th ed)
http://purl.obolibrary.org/obo/SCDO_0000299	Culture	http://purl.obolibrary.org/obo/NCIT_C17047	Quality of Life		A collective expression for all behaviour patterns acquired and socially transmitted through symbols. Culture includes customs, traditions, and language.
http://purl.obolibrary.org/obo/SCDO_0000301	Curative Therapeutics	http://purl.obolibrary.org/obo/SCDO_0001152	Therapeutics		Therapeutics relating to or used in the cure of diseases.
http://purl.obolibrary.org/obo/SCDO_0000304	Current Age	http://purl.obolibrary.org/obo/NCIT_C25150	Age		The length of time that a person has lived since their birth up until the current day.
http://purl.obolibrary.org/obo/SCDO_0000305	Current Educational Attainment	http://purl.obolibrary.org/obo/NCIT_C16495	Demographic Factor		The respondent's highest level of education at the current time.
http://purl.obolibrary.org/obo/SCDO_0000306	Current Employment Status	http://purl.obolibrary.org/obo/NCIT_C16495	Demographic Factor		The respondent's current employment status.
http://purl.obolibrary.org/obo/SCDO_0000310	Blood Cystatin C Level	http://purl.obolibrary.org/obo/CMO_0000023	Blood Chemistry Measurement		The amount of the protein cystatin C (formerly gamma trace, post-gamma-globulin or neuroendocrine basic polypeptide) found in a specified sample of blood. This extracellular cystatin subtype is abundantly expressed in bodily fluids.
http://purl.obolibrary.org/obo/SCDO_0000311	D57 Sickle-Cell Disorders	http://purl.obolibrary.org/obo/SCDO_0000607	ICD-10-CM Diagnosis Codes		A blood disorder characterized by the appearance of sickle-shaped red blood cells and anemia.
http://purl.obolibrary.org/obo/SCDO_0000313	D57.01 Hb-SS disease with acute chest syndrome	http://purl.obolibrary.org/obo/SCDO_0000312	D57.0 Hb-SS disease with crisis		-
http://purl.obolibrary.org/obo/SCDO_0000314	D57.02 Hb-SS disease with splenic sequestration	http://purl.obolibrary.org/obo/SCDO_0000312	D57.0 Hb-SS disease with crisis		-
http://purl.obolibrary.org/obo/SCDO_0000315	D57.1 Sickle-cell disease without crisis	http://purl.obolibrary.org/obo/SCDO_0000311	D57 Sickle-Cell Disorders		-
http://purl.obolibrary.org/obo/SCDO_0000316	D57.2 Sickle-cell/Hb-C disease	http://purl.obolibrary.org/obo/SCDO_0000311	D57 Sickle-Cell Disorders		One of the sickle cell disorders characterized by the presence of both hemoglobin s and hemoglobin c. It is similar to, but less severe than sickle cell anemia.
http://purl.obolibrary.org/obo/SCDO_0000318	D57.21 Sickle-cell/Hb-C disease with crisis	http://purl.obolibrary.org/obo/SCDO_0000316	D57.2 Sickle-cell/Hb-C disease		-
http://purl.obolibrary.org/obo/SCDO_0000319	D57.211 Sickle-cell/Hb-C disease with acute chest syndrome	http://purl.obolibrary.org/obo/SCDO_0000318	D57.21 Sickle-cell/Hb-C disease with crisis		-
http://purl.obolibrary.org/obo/SCDO_0000320	D57.212 Sickle-cell/Hb-C disease with splenic sequestration	http://purl.obolibrary.org/obo/SCDO_0000318	D57.21 Sickle-cell/Hb-C disease with crisis		-
http://purl.obolibrary.org/obo/SCDO_0000321	D57.219 Sickle-cell/Hb-C disease with crisis, unspecified	http://purl.obolibrary.org/obo/SCDO_0000318	D57.21 Sickle-cell/Hb-C disease with crisis		-
http://purl.obolibrary.org/obo/SCDO_0000322	D57.3 Sickle-cell trait	http://purl.obolibrary.org/obo/SCDO_0000311	D57 Sickle-Cell Disorders		The condition of being heterozygous for hemoglobin S.
http://purl.obolibrary.org/obo/SCDO_0000323	D57.4 Sickle-cell thalassemia	http://purl.obolibrary.org/obo/SCDO_0000311	D57 Sickle-Cell Disorders		Hemolytic anemia, in which patients are heterozygous for both the sickle cell gene and a thalassemia gene.
http://purl.obolibrary.org/obo/SCDO_0000324	D57.40 Sickle-cell thalassemia without crisis	http://purl.obolibrary.org/obo/SCDO_0000323	D57.4 Sickle-cell thalassemia		-
http://purl.obolibrary.org/obo/SCDO_0000325	D57.41 Sickle-cell thalassemia, unspecified, with crisis	http://purl.obolibrary.org/obo/SCDO_0000323	D57.4 Sickle-cell thalassemia		-
http://purl.obolibrary.org/obo/SCDO_0000326	D57.411 Sickle-cell thalassemia, unspecified, with acute chest syndrome	http://purl.obolibrary.org/obo/SCDO_0000325	D57.41 Sickle-cell thalassemia, unspecified, with crisis		-
http://purl.obolibrary.org/obo/SCDO_0000327	D57.412 Sickle-cell thalassemia, unspecified, with splenic sequestration	http://purl.obolibrary.org/obo/SCDO_0000325	D57.41 Sickle-cell thalassemia, unspecified, with crisis		-
http://purl.obolibrary.org/obo/SCDO_0000328	D57.419 Sickle-cell thalassemia, unspecified, with crisis	http://purl.obolibrary.org/obo/SCDO_0000325	D57.41 Sickle-cell thalassemia, unspecified, with crisis		-
http://purl.obolibrary.org/obo/SCDO_0000329	D57.8 Other sickle-cell disorders	http://purl.obolibrary.org/obo/SCDO_0000311	D57 Sickle-Cell Disorders		-
http://purl.obolibrary.org/obo/SCDO_0000331	D57.81 Other sickle-cell disorders with crisis	http://purl.obolibrary.org/obo/SCDO_0000329	D57.8 Other sickle-cell disorders		-
http://purl.obolibrary.org/obo/SCDO_0000332	D57.811 Other sickle-cell disorders with acute chest syndrome	http://purl.obolibrary.org/obo/SCDO_0000331	D57.81 Other sickle-cell disorders with crisis		-
http://purl.obolibrary.org/obo/SCDO_0000333	D57.812 Other sickle-cell disorders with splenic sequestration	http://purl.obolibrary.org/obo/SCDO_0000331	D57.81 Other sickle-cell disorders with crisis		-
http://purl.obolibrary.org/obo/SCDO_0000338	obsolete Protein Molecule	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		'Protein molecule are large, complex molecules that play many critical roles in the body. They do most of the work in cells and are required for the structure, function, and regulation of the body's tissues and organs. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000343	Delta Beta Thalassemia	http://purl.obolibrary.org/obo/SCDO_0000111	Beta Thalassemia		A form of beta-thalassemia characterized by decreased or absent synthesis of the delta- and beta-globin chains with a compensatory increase in expression of fetal gamma-chain synthesis.
http://purl.obolibrary.org/obo/SCDO_0000344	Delta Thalassemia	http://purl.obolibrary.org/obo/NCIT_C35069	Thalassemia		A hereditary disorder characterized by reduced or absent delta-globin thus effecting the level of hemoglobin A2, a minor component of adult hemoglobin monitored in the diagnosis of beta-thalassemia.
http://purl.obolibrary.org/obo/SCDO_0000346	Dengue Fever	http://purl.obolibrary.org/obo/NCIT_C3439	Viral Infection		An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with Dengue Virus. It is self-limiting and characterized by fever, myalgia, headache, and rash. Severe Dengue is a more virulent form of dengue.
http://purl.obolibrary.org/obo/SCDO_0000347	deprecated Dental System	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		'The system pertaining to teeth, oral cavity, and associated structures. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000360	Depression	http://purl.obolibrary.org/obo/SCDO_0000954	Quality of Life Related SCD Symptoms and Complications		A common mental disorder, characterized by sadness, hopelessness, loss of interest or pleasure, feelings of guilt or low self-worth, disturbed sleep or appetite, feelings of tiredness, and poor concentration. Depression can be long-lasting or recurrent, substantially impairing an individual's ability to function at work or school or cope with daily life.
http://purl.obolibrary.org/obo/SCDO_0000365	Dexterity	http://purl.obolibrary.org/obo/SCDO_0000900	Physical Functioning		Skill in performing tasks, especially with the hands.
http://purl.obolibrary.org/obo/SCDO_0000376	Diagnostic Device	http://purl.obolibrary.org/obo/SCDO_0000379	Diagnostics		A medical device used to diagnose medical conditions.
http://purl.obolibrary.org/obo/SCDO_0000379	Diagnostics	http://purl.obolibrary.org/obo/SCDO_0001000	SCDO		Diagnostic tools (including the instruments, laboratory assays and methods of patient examination) used for differential diagnosis, the measurements obtained using these tools, and the diagnostic devices used in obtaining the measurements.
http://purl.obolibrary.org/obo/SCDO_0000380	Diclofenac	http://purl.obolibrary.org/obo/CHEBI_35475	Non-Steroidal Anti-Inflammatory Drug		A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
http://purl.obolibrary.org/obo/SCDO_0000382	Diet, Food, and Nutrition	http://purl.obolibrary.org/obo/SCDO_0000487	Health Behaviour		Concepts involved with nutritional physiology, including categories of substances eaten for sustenance, nutritional phenomena and processes, eating patterns and habits, and measurable nutritional parameters.
http://purl.obolibrary.org/obo/SCDO_0000384	Diffusion Capacity of Lung	http://purl.obolibrary.org/obo/CMO_0000094	Respiratory System Measurement		The amount of a gas taken up, by the pulmonary capillary blood from the alveolar gas, per minute per unit of average pressure of the gradient of the gas across the blood-air barrier.
http://purl.obolibrary.org/obo/SCDO_0000385	Diffusion Capacity Test	http://purl.obolibrary.org/obo/SCDO_0000942	Pulmonary Function Test		Clinical assessment to determine the capacity of an individual's lung to exchange gases (e.g., oxygen and carbon dioxide) across the alveolar-capillary interface.
http://purl.obolibrary.org/obo/SCDO_0000386	Disability-Adjusted Life Year (DALY)	http://purl.obolibrary.org/obo/SCDO_0000951	Quality of Life and Care Measure		One DALY can be thought of as one lost year of "healthy" life. The sum of these DALYs across the population, or the burden of disease, can be thought of as a measurement of the gap between current health status and an ideal health situation where the entire population lives to an advanced age, free of disease and disability.
http://purl.obolibrary.org/obo/SCDO_0000388	Disaster	http://purl.obolibrary.org/obo/SCDO_0000897	Physical Environment		Sudden calamitous events producing great material damage, loss, and distress. They are the result of natural phenomena such as earthquakes, floods, etc. Calamities producing great damage, loss of life, and distress. They include results of natural phenomena and man-made phenomena. Normal conditions of existence are disrupted and the level of impact exceeds the capacity of the hazard-affected community.
http://purl.obolibrary.org/obo/SCDO_0000391	Disease Modifier	http://purl.obolibrary.org/obo/SCDO_0001000	SCDO		A factor that modifies one or more aspects of a disease, such as sickle cell disease (SCD) (e.g. aspects such as temporal pattern, age of onset and mortality), for specific phenotype(s) of the disease.
http://purl.obolibrary.org/obo/SCDO_0000397	Drug Clearance Decreased AE	http://purl.obolibrary.org/obo/SCDO_0000028	Adverse Drug Event		An adverse event that has an outcome of a decreased amount of the drug excreted by the body.
http://purl.obolibrary.org/obo/SCDO_0000398	Drug Dependence AE	http://purl.obolibrary.org/obo/SCDO_0000028	Adverse Drug Event		An adverse drug event that results in the development of a dependence on the drug.
http://purl.obolibrary.org/obo/SCDO_0000399	Drug Intake	http://purl.obolibrary.org/obo/SCDO_0000487	Health Behaviour		The amount of drug substances taken into the body.
http://purl.obolibrary.org/obo/SCDO_0000400	Drug Intolerance AE	http://purl.obolibrary.org/obo/SCDO_0000028	Adverse Drug Event		A drug AE that has an outcome of lower threshold to the normal pharmacologic action of a drug.
http://purl.obolibrary.org/obo/SCDO_0000401	Drug Withdrawal Syndrome AE	http://purl.obolibrary.org/obo/SCDO_0000028	Adverse Drug Event		An adverse event that results in symptoms that occur after the discontinuation of the use of a certain drug.
http://purl.obolibrary.org/obo/SCDO_0000402	Drug-Induced Neuropathy AE	http://purl.obolibrary.org/obo/SCDO_0000191	Causal Adverse Drug Event		A neuropathy AE that is induced by a drug administration.
http://purl.obolibrary.org/obo/SCDO_0000405	deprecated Ear, Nose and Throat	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		'The combined specialties of diseases of the ear, pharynx, and larynx, including the upper respiratory tract and diseases of the head and neck, tracheobronchial tree, and esophagus. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000407	Ecchymosis	http://purl.obolibrary.org/obo/HP_0002597	Abnormality of the Vasculature		A small hemorrhagic spot, larger than a petechia, in the skin or mucous membrane forming a nonelevated, rounded or irregular, blue or purplish patch.
http://purl.obolibrary.org/obo/SCDO_0000409	Echocardiogram	http://purl.obolibrary.org/obo/NCIT_C17230	Ultrasound Test		A physiological assay that uses standard ultrasound techniques to take two-dimensional pictures of the cardiovascular system and can produce accurate assessment of the velocity of blood and cardiac tissue at any arbitrary point using pulsed or continuous wave Doppler ultrasound.
http://purl.obolibrary.org/obo/SCDO_0000410	Echocardiography Machine	http://purl.obolibrary.org/obo/SCDO_0000376	Diagnostic Device		A machine used for ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues.
http://purl.obolibrary.org/obo/SCDO_0000414	Education	http://purl.obolibrary.org/obo/NCIT_C17047	Quality of Life		Acquisition of knowledge as a result of instruction in a formal course of study.
http://purl.obolibrary.org/obo/SCDO_0000416	Electrocardiographic Monitor	http://purl.obolibrary.org/obo/SCDO_0000376	Diagnostic Device		Device which makes prolonged electrocardiographic recordings on a portable tape recorder (Holter-type system) or solid-state device (real-time system), while the patient undergoes normal daily activities; useful in the diagnosis and management of intermittent cardiac arrhythmias and transient myocardial ischemia.
http://purl.obolibrary.org/obo/SCDO_0000417	Electrocardiography	http://purl.obolibrary.org/obo/SCDO_0000500	Heart Function Test		Recording of the moment-to-moment electromotive forces of the heart as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a cathode ray tube display.
http://purl.obolibrary.org/obo/SCDO_0000418	Electroencephalogram	http://purl.obolibrary.org/obo/SCDO_1000313	Diagnostic Device Visual Output		A graphic record of the electrical activity of the brain as recorded by an electroencephalograph.
http://purl.obolibrary.org/obo/SCDO_0000419	Electroencephalograph	http://purl.obolibrary.org/obo/SCDO_0000376	Diagnostic Device		An instrument that measures electrical potentials on the scalp and generates a record of the electrical activity of the brain.
http://purl.obolibrary.org/obo/SCDO_0000420	Electroencephalography	http://purl.obolibrary.org/obo/SCDO_0000208	Cerebral Function Assay		Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.
http://purl.obolibrary.org/obo/SCDO_0000431	deprecated Endocrine and Metabolic	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		The system pertaining to the stomach, intestines, and associated organs including liver, gallbladder, and pancreas.
http://purl.obolibrary.org/obo/SCDO_0000435	Environmental Disease Modifier	http://purl.obolibrary.org/obo/SCDO_0000391	Disease Modifier		An environmental factor that modifies one or more aspects of sickle cell disease (SCD) (such as temporal pattern, age of onset and mortality) for specific phenotype(s) in the Phenotype class.
http://purl.obolibrary.org/obo/SCDO_0000436	Enzymatic Assay	http://purl.obolibrary.org/obo/SCDO_0000120	Biochemical Assay		A method used to measure the relative activity of a specific enzyme or its concentration in solution. Typically an enzyme substrate is added to a buffer solution containing enzyme and the rate of conversion of substrate to product is measured under controlled conditions. Many classical enzymatic assay methods involve the use of synthetic colorimetric substrates and measuring the reaction rates using a spectrophotometer.
http://purl.obolibrary.org/obo/SCDO_0000437	Epidemiologic Studies	http://purl.obolibrary.org/obo/SCDO_0006339	Research		Studies designed to examine associations, commonly, hypothesized causal relations. They are usually concerned with identifying or measuring the effects of risk factors or exposures. The common types of analytic study are case-control studies; cohort studies; and cross-sectional studies.
http://purl.obolibrary.org/obo/SCDO_0000438	deprecated Epidemiologic Study Characteristics as Topic	http://purl.obolibrary.org/obo/SCDO_0000990	obsolete Research Activity		Types and formulations of studies used in epidemiological and clinical research.
http://purl.obolibrary.org/obo/SCDO_0000440	Epilepsy Screener	http://purl.obolibrary.org/obo/NCIT_C91105	Clinical or Research Assessment Questionnaire		A questionnaire to assess epilepsy, a condition characterized by recurrent seizures and which is a component of over 40 neurological disorders (Aminoff, et al., 2005).
http://purl.obolibrary.org/obo/SCDO_0000441	General Health Questionnaire (GHQ)	http://purl.obolibrary.org/obo/SCDO_0000953	Quality of Life Measure		The GHQ is a screening device for identifying minor psychiatric disorders in the general population and within community or non-psychiatric clinical settings such as primary care or general medical outpatients. Suitable for all ages from adolescent upwards (not children), it assesses the respondent's current state and asks if that differs from his or her usual state. It is therefore sensitive to short-term psychiatric disorders but not to long-standing attributes of the respondent. The self-administered questionnaire focuses on two major areas: inability to carry out normal functions; appearance of new and distressing phenomena. It is available in the following versions: GHQ-60 -- the fully detailed 60-item questionnaire; GHQ-30 -- a short form without items relating to physical illness; GHQ-28 -- a 28 item scaled version -- assesses somatic symptoms, anxiety and insomnia, social dysfunction and severe depression; GHQ-12 -- quick, reliable and sensitive short form, ideal for research studies.
http://purl.obolibrary.org/obo/SCDO_0000442	Generalised Anxiety Disorder Questionnaire (GAD-7)	http://purl.obolibrary.org/obo/SCDO_1000297	Quality of Life and Care Diagnostic Instrument		The GAD-7 is a self-administered patient questionnaire used as a screening tool and severity measure for generalised anxiety disorder. The GAD-7 score is calculated by assigning scores of 0, 1, 2, and 3, to the response categories of 'not at all', 'several days', 'more than half the days', and 'nearly every day', respectively, and adding together the scores for the seven questions. Scores of 5, 10, and 15 are taken as the cut-off points for mild, moderate and severe anxiety, respectively. When used as a screening tool, further evaluation is recommended when the score is 10 or greater.
http://purl.obolibrary.org/obo/SCDO_0000443	Genetic Counseling	http://purl.obolibrary.org/obo/SCDO_0000447	Genetic Service		An educational process that provides information and advice to individuals or families about a genetic condition that may affect them. The purpose is to help individuals make informed decisions about marriage, reproduction, and other health management issues based on information about the genetic disease, the available diagnostic tests, and management programs. Psychosocial support is usually offered.
http://purl.obolibrary.org/obo/SCDO_0000444	Genetic Disease Modifier	http://purl.obolibrary.org/obo/SCDO_0000122	Biological Disease Modifier		A biological disease modifier that is of a genetic nature.
http://purl.obolibrary.org/obo/SCDO_0000447	Genetic Service	http://purl.obolibrary.org/obo/SCDO_0000922	Preventative Therapeutics		Organized services to provide diagnosis, treatment, and prevention of genetic disorders.
http://purl.obolibrary.org/obo/SCDO_0000448	Genetic Technique	http://purl.obolibrary.org/obo/SCDO_0000082	Diagnostic Technique, Method, Test or Assay		Chromosomal, biochemical, intracellular, and other methods used in the study of genetics.
http://purl.obolibrary.org/obo/SCDO_0000454	Glaucoma (Secondary to Presence of Blood in the Anterior Chamber of the Eye)	http://purl.obolibrary.org/obo/HP_0000478	Abnormality of the Eye		Elevated ocular pressure caused by clogging of the trabecular meshwork and by impaired aqueous humor outflow from blood in the anterior chamber (due to ocular trauma or surgery).
http://purl.obolibrary.org/obo/SCDO_0000456	Globin Locus	http://purl.obolibrary.org/obo/SCDO_1000103	Genetic Locus		A genetic locus responsible for the encoding of globins.
http://purl.obolibrary.org/obo/SCDO_0000457	Glomerular Filtration Rate	http://purl.obolibrary.org/obo/CMO_0000023	Blood Chemistry Measurement		Measurement of the flow rate of filtered fluid through the kidney, calculated either by comparative measurements of substances in the blood and urine, or estimated from a blood test.
http://purl.obolibrary.org/obo/SCDO_0000462	G6PD	http://purl.obolibrary.org/obo/SCDO_0000810	Non-Globin Gene		This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene.
http://purl.obolibrary.org/obo/SCDO_0000465	Growth Delay	http://purl.obolibrary.org/obo/SCDO_0000954	Quality of Life Related SCD Symptoms and Complications		A deficiency or slowing down of growth pre- and postnatally greater than two standard deviations from the age- and sex-related normal.
http://purl.obolibrary.org/obo/SCDO_0000487	Health Behaviour	http://purl.obolibrary.org/obo/SCDO_0000435	Environmental Disease Modifier		Individual lifestyle and behavior which may or may not enhance or maintain good health.
http://purl.obolibrary.org/obo/SCDO_0000488	Health Beliefs	http://purl.obolibrary.org/obo/SCDO_0000299	Culture		People's beliefs about health problems, perceived benefits of action and barriers to action, and self-efficacy.
http://purl.obolibrary.org/obo/SCDO_0000489	Health Financing	http://purl.obolibrary.org/obo/SCDO_0000494	Health System		Health financing is concerned with how financial resources are generated, allocated and used in health systems. Health financing policy focuses on how to move closer to universal coverage with issues related to: (i) how and from where to raise sufficient funds for health; (ii) how to overcome financial barriers that exclude many poor from accessing health services; or (iii) how to provide an equitable and efficient mix of health services.
http://purl.obolibrary.org/obo/SCDO_0000491	Health Literacy	http://purl.obolibrary.org/obo/SCDO_0000286	Coping Skill		Degree to which individuals have the capacity to obtain, process and understand basic health information and services needed to make appropriate health decisions.
http://purl.obolibrary.org/obo/SCDO_0000494	Health System	http://purl.obolibrary.org/obo/SCDO_0000948	Quality of Health Care		A system responsible for delivering services that improve, maintain or restore the health of individuals and their communities. This includes the care provided by hospitals and family doctors, but also less visible tasks such as the prevention and control of communicable disease, health promotion, health workforce planning and improving the social, economic or environmental conditions in which people live.
http://purl.obolibrary.org/obo/SCDO_0000495	Health Utility	http://purl.obolibrary.org/obo/SCDO_0000948	Quality of Health Care		Utility measures of health related quality of life are preference values that patients attach to their overall health status. In clinical trials, utility measures summarize both positive and negative effects of an intervention into one value between 0 (equal to death) and 1 (equal to perfect health). These measures allow for comparison of patient outcomes of different diseases, and for comparison between various health care interventions. There are 2 different approaches to utility measurement.
http://purl.obolibrary.org/obo/SCDO_0000496	Healthcare Access	http://purl.obolibrary.org/obo/SCDO_0000948	Quality of Health Care		The ease with which an individual can obtain needed medical services.
http://purl.obolibrary.org/obo/SCDO_0000497	Healthy Diet	http://purl.obolibrary.org/obo/NCIT_C15900	Lifestyle Therapy		Dietary patterns which have been found to be important in reducing disease risk.
http://purl.obolibrary.org/obo/SCDO_0000498	Healthy Lifestyle	http://purl.obolibrary.org/obo/SCDO_0000689	Lifestyle		A pattern of behavior involving lifestyle choices which ensure optimum health. Examples are eating right; maintaining physical, emotional, and spiritual wellness, and taking preemptive steps against communicable diseases.
http://purl.obolibrary.org/obo/SCDO_0000500	Heart Function Test	http://purl.obolibrary.org/obo/SCDO_0000902	Physiological Assay		Examinations used to diagnose and treat heart conditions.
http://purl.obolibrary.org/obo/SCDO_0000501	Heart Rate	http://purl.obolibrary.org/obo/SCDO_1000317	Heart Measurement		The number of times the heart ventricles contract per unit of time, usually per minute.
http://purl.obolibrary.org/obo/SCDO_0000502	Heart Valve Measurement	http://purl.obolibrary.org/obo/SCDO_1000317	Heart Measurement		Any value resulting from the quantification of a morphological or physiological parameter pertaining to the heart valves.
http://purl.obolibrary.org/obo/SCDO_0000504	Hematology Analyzer	http://purl.obolibrary.org/obo/SCDO_0000376	Diagnostic Device		A measurement device used to perform complete blood counts, erythrocyte sedimentation rates (ESRs), or coagulation tests.
http://purl.obolibrary.org/obo/SCDO_0000507	deprecated Hematopoietic System	http://purl.obolibrary.org/obo/SCDO_0000511	obsolete Hemic and Immune Systems		The blood-making organs and tissues, principally the bone marrow and lymph nodes.
http://purl.obolibrary.org/obo/SCDO_0000508	Hematuria	http://purl.obolibrary.org/obo/HP_0000077	Abnormality of the Kidney		Presence of blood in the urine.
http://purl.obolibrary.org/obo/SCDO_0000510	HMOX1	http://purl.obolibrary.org/obo/SCDO_0000810	Non-Globin Gene		This gene encodes the enzyme, heme oxygenase 1, an essential enzyme in heme catabolism and cellular homeostasis.
http://purl.obolibrary.org/obo/SCDO_0000511	obsolete Hemic and Immune Systems	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		Organs involved in the production of BLOOD, including the cellular and the molecular components essential in providing defense against foreign organisms or substances.
http://purl.obolibrary.org/obo/SCDO_0000513	Hemoglobin C	http://purl.obolibrary.org/obo/SCDO_0003807	Abnormal Hemoglobin		A commonly occurring abnormal hemoglobin in which lysine replaces a glutamic acid residue at the sixth position of the beta chains. It results in reduced plasticity of erythrocytes.
http://purl.obolibrary.org/obo/SCDO_0000515	Hemoglobin H	http://purl.obolibrary.org/obo/SCDO_0003807	Abnormal Hemoglobin		An abnormal hemoglobin composed of four beta chains. It is caused by the reduced synthesis of the alpha chain. This abnormality results in alpha-thalassemia.
http://purl.obolibrary.org/obo/SCDO_0000517	Hemoglobin Barts	http://purl.obolibrary.org/obo/SCDO_0003807	Abnormal Hemoglobin		An abnormal hemoglobin, composed of four gamma globin chains, causing it to have an extremely high affinity for oxygen, resulting in almost no oxygen delivery to the tissues.
http://purl.obolibrary.org/obo/SCDO_0000518	Hemoglobin Barts Hydrops Fetalis	http://purl.obolibrary.org/obo/SCDO_0000042	Alpha Thalassemia		The most severe form of alpha-thalassemia and is almost always lethal, and characterized by fetal onset of generalized edema, pleural and pericardial effusions, and severe hypochromic anemia. It is caused by the presence of Hemoglobin Barts, a hemoglobin with four gamma chains, which has an extremely high affinity for oxygen, resulting in almost no oxygen delivery to the tissues
http://purl.obolibrary.org/obo/SCDO_0000519	Hemoglobin C Disease	http://purl.obolibrary.org/obo/SCDO_0008262	Structural Hemoglobinopathy		An autosomal recessive disorder resulting from the production of hemoglobin C, secondary to an amino acid substitution of lysine for glutamic acid in the sixth position of the beta chain (E6K), and characterized by mild hemolytic anemia and occasionally jaundice, though most patients are asymptomatic.
http://purl.obolibrary.org/obo/SCDO_0000520	Hemoglobin C Trait	http://purl.obolibrary.org/obo/NCIT_C95534	Hemoglobin Trait		The inheritance of the gene for hemoglobin C from one parent and a gene for normal adult hemoglobin (hemoglobin A) from the other parent.
http://purl.obolibrary.org/obo/SCDO_0000522	Hemoglobin Variant Test	http://purl.obolibrary.org/obo/SCDO_0000133	Blood Test		A test to measure the presence and amount of a variant of hemoglobin in the blood.
http://purl.obolibrary.org/obo/SCDO_0000524	Hemoglobin D Disease	http://purl.obolibrary.org/obo/SCDO_0008262	Structural Hemoglobinopathy		An autosomal recessive hemoglobinopathy characterized by production of abnormal variant hemoglobin known as hemoglobin D, with no or mild clinical manifestations (splenomegaly, very mild anemia).
http://purl.obolibrary.org/obo/SCDO_0000525	Hemoglobin D Trait	http://purl.obolibrary.org/obo/NCIT_C95534	Hemoglobin Trait		The inheritance of the gene for hemoglobin D from one parent and a gene for normal adult hemoglobin (hemoglobin A) from the other parent.
http://purl.obolibrary.org/obo/SCDO_0000526	deprecated Hemoglobin D-Beta Thalassemia	http://purl.obolibrary.org/obo/SCDO_0000272	obsolete Compound Heterozygous Hemoglobinopathy		'Hemoglobin D/xcexb2xc2xb0 thalassemia is a form of beta-thalassemia which results in a mild to moderate clinical picture. The severity of the condition depends on the degree of thalassemia and how it affects production of Hemoglobin A, however this condition is often considered fairly benign.'
http://purl.obolibrary.org/obo/SCDO_0000527	Hemoglobin D-Ibadan	http://purl.obolibrary.org/obo/SCDO_1000259	Unusual Hemoglobin		An unusual hemoglobin that shows all the electrophoretic features of Hb D, but has no inherited disability. This hemoglobin has a beta 87 Thr > Lys mutation.
http://purl.obolibrary.org/obo/SCDO_0000528	Hemoglobin D-Punjab	http://purl.obolibrary.org/obo/SCDO_1000007	Hemoglobin D		An abnormal hemoglobin (one of the types of hemoglobin D) in which glutamine replaces glutamic acid at codon 121 of beta globin.
http://purl.obolibrary.org/obo/SCDO_0000529	deprecated Hemoglobin Disease Other than C,D,E,F,H,O-Arab,S	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		A disease caused by atypical hemoglobins molecules other than hemoglobin C,D,E, F, H, O-Arab and S.
http://purl.obolibrary.org/obo/SCDO_0000530	Hemoglobin E Disease	http://purl.obolibrary.org/obo/SCDO_0008262	Structural Hemoglobinopathy		An autosomal recessive haemoglobinopathy characterized by an abnormal form of haemoglobin called haemoglobin E, which disrupts the oxygen-carrying ability of red blood cells. The condition can lead to mild or moderate hemolytic anemia; however, this condition often has no clinical manifestations.
with a generally benign, asymptomatic presentation.
http://purl.obolibrary.org/obo/SCDO_0000532	deprecated Hemoglobin E-Beta Thalassemia	http://purl.obolibrary.org/obo/SCDO_0000272	obsolete Compound Heterozygous Hemoglobinopathy		'Hemoglobin E/xcexb2+ thalassemia is a form of beta-thalassemia that is often, but not always, milder than hemoglobin E/xcexb2xc2xb0 thalassemia. This condition shows a marked clinically diverse picture whereby abnormalities of xcexb2-globin chain synthesis result almost asymptomatic anemia to more severe transfusion-dependant anemia (Vichinsky, 2007).'
http://purl.obolibrary.org/obo/SCDO_0000533	deprecated Hemoglobin F Profile	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		The score of fetal hemoglobin (Hb F) in the blood of an individual.
http://purl.obolibrary.org/obo/SCDO_0000535	obsolete Hemoglobin Lepore Baltimore	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		A variant of Hemoglobin Lepore Syndrome.
http://purl.obolibrary.org/obo/SCDO_0000536	Hemoglobin Lepore Boston Disease	http://purl.obolibrary.org/obo/NCIT_C141366	Hemoglobin Lepore Syndrome		A variant of Hemoglobin Lepore Syndrome. Crossover occurs between glutamine at position 87 of delta chain and histidine at position 116 of beta chain. It is associated with unusual high levels of Hb F. This is the only one of the three variants of described in association with HbS.
http://purl.obolibrary.org/obo/SCDO_0000537	obsolete Hemoglobin Lepore Hollandia	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		A variant of Hemoglobin Lepore Syndrome.
http://purl.obolibrary.org/obo/SCDO_0000540	deprecated Hemoglobin Lepore-Beta Thalassaemia	http://purl.obolibrary.org/obo/SCDO_0000272	obsolete Compound Heterozygous Hemoglobinopathy		'A form of beta-thalassemia in which the patient is compound heterozygous for hemoglobin lepore and beta-thalassemia, which results in beta-thalassemia intermedia to beta-thalassemia major. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000541	Hemoglobin M Disease	http://purl.obolibrary.org/obo/SCDO_0008262	Structural Hemoglobinopathy		A type of dominant hereditary methemoglobinemia resulting from the production of hemoglobin M, which is readily oxidised to yield excess methemoglobin which leads to cyanosis.
http://purl.obolibrary.org/obo/SCDO_0000544	Hemoglobin O-Arab Disease	http://purl.obolibrary.org/obo/SCDO_0008262	Structural Hemoglobinopathy		A very rare autosomal recessive hemoglobinopathy characterized by an abnormal form of hemoglobin called hemoglobin O-Arab. It is associated with a mild to moderate anemia.
http://purl.obolibrary.org/obo/SCDO_0000545	Hemoglobin O-Arab Trait	http://purl.obolibrary.org/obo/NCIT_C95534	Hemoglobin Trait		The inheritance of hemoglobin O-Arab from one parent and a gene for normal adult hemoglobin (hemoglobin A) from the other parent.
http://purl.obolibrary.org/obo/SCDO_0000546	Hemoglobin Profile	http://purl.obolibrary.org/obo/CMO_0000508	Hemoglobin Measurement		The type and relative amounts of various normal and abnormal hemoglobin types.
http://purl.obolibrary.org/obo/SCDO_0000547	Hemoglobin Profile Assay	http://purl.obolibrary.org/obo/SCDO_0000133	Blood Test		A bioassay that measures and identifies the different types of hemoglobin in the bloodstream. It can be used to identify and characterize the different variants in structure and synthesis of hemoglobin that cause sickle cell disease.
http://purl.obolibrary.org/obo/SCDO_0000548	Hemoglobin S Test	http://purl.obolibrary.org/obo/SCDO_0000522	Hemoglobin Variant Test		A test to quantify the presence of hemoglobin S in the blood and therefore determine whether a person has sickle cell trait or sickle cell disease.
http://purl.obolibrary.org/obo/SCDO_0000551	Thalassemia Trait	http://purl.obolibrary.org/obo/NCIT_C95534	Hemoglobin Trait		The inheritance of one of the faulty genes that causes thalassemia.
http://purl.obolibrary.org/obo/SCDO_0000552	Hemoglobinopathy	http://purl.obolibrary.org/obo/SCDO_0001000	SCDO		An inherited disorder of the structure and/or synthesis of hemoglobin, with a variable phenotype expression ranging from benign to severe.
http://purl.obolibrary.org/obo/SCDO_0000553	obsolete Hemoglobinopathy Toms River	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		Hemoglobinopathy Toms River, is also known as transient neonatal cyanosis and anemia due to toms river hemoglobin. An important gene associated with Hemoglobinopathy Toms River is HBG2 (Hemoglobin Subunit Gamma 2.
http://purl.obolibrary.org/obo/SCDO_0000556	Hepatic Span	http://purl.obolibrary.org/obo/CMO_0000021	Body Morphological Measurement		The distance between the lower border of the liver in the mid-clavicular line, and the upper border of the liver in the mid-clavicular line.
http://purl.obolibrary.org/obo/SCDO_0000557	obsolete Hepatitis B Test	http://purl.obolibrary.org/obo/SCDO_1000034	from diagnostics		A test for Hepatitis B Virus.
http://purl.obolibrary.org/obo/SCDO_0000558	obsolete Hepatitis C Test	http://purl.obolibrary.org/obo/SCDO_1000034	from diagnostics		A test for Hepatitis C Virus.
http://purl.obolibrary.org/obo/SCDO_0000559	Hereditary Methemoglobinemia	http://purl.obolibrary.org/obo/SCDO_0000753	Methemoglobinemia		A rare red cell disorder classified principally into two clinical phenotypes: autosomal recessive congenital (or hereditary) methemoglobinemia types I and II (RCM/RHM type 1; RCM/RHM type 2).
http://purl.obolibrary.org/obo/SCDO_0000564	Hip Replacement Arthroplasty	http://purl.obolibrary.org/obo/SCDO_0001133	Symptomatic Therapeutics		Replacement of the hip joint.
http://purl.obolibrary.org/obo/SCDO_0000565	Historically Controlled Study	http://purl.obolibrary.org/obo/SCDO_0000437	Epidemiologic Studies		A study that compares a group of participants receiving an intervention with a similar group from the past who did not.
http://purl.obolibrary.org/obo/SCDO_0000566	History of Head Trauma Diagnostic Instrument	http://purl.obolibrary.org/obo/NCIT_C91105	Clinical or Research Assessment Questionnaire		A questionnaire to determine whether an individual has had a traumatic brain injury (TBI).
http://purl.obolibrary.org/obo/SCDO_0000567	History of Kidney Failure Diagnostic Instrument	http://purl.obolibrary.org/obo/NCIT_C91105	Clinical or Research Assessment Questionnaire		A questionnaire to determine if the respondent has a history of kidney failure.
http://purl.obolibrary.org/obo/SCDO_0000568	History of Stroke - Ischemic Infarction and Hemorrhage - Diagnostic Instrument	http://purl.obolibrary.org/obo/NCIT_C91105	Clinical or Research Assessment Questionnaire		A questionnaire to determine if the respondent has had an ischemic infarction (i.e. stroke) and/or any symptoms related to this event.
http://purl.obolibrary.org/obo/SCDO_0000570	History of Type I and Type 2 Diabetes Diagnostic Instrument	http://purl.obolibrary.org/obo/NCIT_C91105	Clinical or Research Assessment Questionnaire		A questionnaire to determine a respondent's history of type 1 or type 2 diabetes.
http://purl.obolibrary.org/obo/SCDO_0000571	HIV Test	http://purl.obolibrary.org/obo/SCDO_0000133	Blood Test		A bioassay to measure human immunodeficiency virus (HIV) antibodies and/or HIV antigens in order to determine whether an individual has an HIV infection.
http://purl.obolibrary.org/obo/SCDO_0000572	Hospital Anxiety and Depression Scale (HADS)	http://purl.obolibrary.org/obo/SCDO_1000297	Quality of Life and Care Diagnostic Instrument		The HADS consists of 2 subscales each with 7 items for measuring anxiety, and 7 items for depression rated from 0 - 3. Anxiety and depression scores are obtained by adding up the ratings of the items on each subscale. A score above 8 in any of the subscales indicates that the patient has experienced clinically significant anxiety or depression over the past week.
http://purl.obolibrary.org/obo/SCDO_0000573	Hospitalization	http://purl.obolibrary.org/obo/SCDO_0000493	Health Service Utilization		The confinement of a patient in a hospital.
http://purl.obolibrary.org/obo/SCDO_0000574	Household Roster-Relationships	http://purl.obolibrary.org/obo/NCIT_C16495	Demographic Factor		A record of those living in the respondent's household and about his or her relationship with them.
http://purl.obolibrary.org/obo/SCDO_0000576	Hydration Therapy	http://purl.obolibrary.org/obo/NCIT_C15900	Lifestyle Therapy		A unique treatment that administers electrolyte-packed IV fluids directly into a patient's bloodstream. Depending on the patient's needs, the fluid may be enhanced with additives such as calcium, magnesium sulfate or a Vitamin B complex. It is a far more efficient method of absorption when compared to the traditional method of drinking liquids/electrolytes.
http://purl.obolibrary.org/obo/SCDO_0000580	Hydroxyurea	http://purl.obolibrary.org/obo/CHEBI_23888	Drug		An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
http://purl.obolibrary.org/obo/SCDO_0000581	Hydroxyurea-Induced Adverse Event	http://purl.obolibrary.org/obo/SCDO_0000191	Causal Adverse Drug Event		A causal adverse drug event that is induced by hydroxyurea.
http://purl.obolibrary.org/obo/SCDO_0000582	Hydroxyurea-Induced Cutaneous Adverse Event	http://purl.obolibrary.org/obo/SCDO_0000581	Hydroxyurea-Induced Adverse Event		A hydroxyurea-induced adverse event that has an outcome relating to or affecting the skin.
http://purl.obolibrary.org/obo/SCDO_0000583	Hydroxyurea-Induced Splenomegaly Adverse Event	http://purl.obolibrary.org/obo/SCDO_0000581	Hydroxyurea-Induced Adverse Event		A hydroxyurea-induced adverse event that has the outcome of splenomegaly.
http://purl.obolibrary.org/obo/SCDO_0000588	Hyperkalemia	http://purl.obolibrary.org/obo/SCDO_0002674	Abnormality of Metabolism/Homeostasis		Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinically by electrocardiographic abnormalities (elevated T waves and depressed P waves, and eventually by atrial asystole). In severe cases, weakness and flaccid paralysis may occur. (Dorland, 27th ed).
http://purl.obolibrary.org/obo/SCDO_0000593	Hyperpigmentation	http://purl.obolibrary.org/obo/HP_0011121	Abnormality of Skin Morphology		Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance.
http://purl.obolibrary.org/obo/SCDO_0000607	ICD-10-CM Diagnosis Codes	http://purl.obolibrary.org/obo/SCDO_0000245	Clinical Coding		The ICD-10-CM diagnosis classification system developed by the Centers for Disease Control and Prevention for use in all U.S. health care treatment settings. Diagnosis coding under this system uses a different number of digits and some other changes, but the format is very much the same as ICD-9-CM. The National Center for Health Statistics (NCHS), the Federal agency responsible for use of the International Statistical Classification of Diseases and Related Health Problems, 10th revision (ICD-10) in the United States, has developed a clinical modification of the classification for morbidity purposes. The ICD-10 is used to code and classify mortality data from death certificates, having replaced ICD-9 for this purpose as of January 1, 1999. ICD-10-CM is the replacement for ICD-9-CM, volumes 1 and 2, effective October 1, 2015.
http://purl.obolibrary.org/obo/SCDO_0000611	Illness Perception Questionnaire Revised (IPQ-R)	http://purl.obolibrary.org/obo/SCDO_0000951	Quality of Life and Care Measure		The IPQ-R is an 84-item self-completed instrument developed to provide a quantitative measurement of the components of illness representations, as described by Leventhal's Common-Sense Model (CSM) of selfregulation it is divided into 3 sections: identity subscale (14 symptoms), causal subscale (18 causes), and a third section which contains 7 subscales, including consequences, timeline acute/chronic and cyclical, personal and treatment control/cure, illness coherence, and emotional representations. The questionnaire wording can be adapted to the specific illness by replacing the word illness with the name of the condition. For the identity subscale, respondents are asked if they have experienced a number of symptoms since their illness, and if they feel the symptoms are related to their current illness. Response is by circling 'yes' or 'no' to each question. Responses are then summed to give an overall score. For the causal subscale, respondents are asked what they perceive to be the cause of their illness and are asked to respond to each of the listed causes using a 5-point Likert style scale, ranging from strongly disagree to strongly agree. Respondents are also asked to rank the 3 most important factors believed to be the cause of their illness. The third section (7 subscales) is scored by summing responses to each item is on a 5-point Likert style scale, ranging from strongly disagree to strongly agree. All items for each of the subscales are summed to give an overall score. High scores on the identity, consequences, timeline acute/chronic and cyclical subscales represent strongly held beliefs about the number of symptoms attributed, the negative consequences, and the chronicity and cyclical nature of the illness. High scores on the personal and treatment control and coherence subscales represent positive beliefs about controllability and a personal understanding of the illness.
http://purl.obolibrary.org/obo/SCDO_0000615	deprecated Immune System	http://purl.obolibrary.org/obo/SCDO_0000511	obsolete Hemic and Immune Systems		The body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components.
http://purl.obolibrary.org/obo/SCDO_0000618	Immunosuppressant Drug Level Decreased AE	http://purl.obolibrary.org/obo/SCDO_0000028	Adverse Drug Event		A drug adverse event that has an outcome of decreased levels of immunosuppressant drugs in the patient's body.
http://purl.obolibrary.org/obo/SCDO_0000619	Immunoturbidimetry Assay	http://purl.obolibrary.org/obo/NCIT_C16723	Immunological Assay		An assay that employs immunoturbidimetry, a method that measures the absorbance of light from a sample which is used for quantifying an amount of analyte based on the level of turbidity produced by the formation and precipitation of an immune complex containing the analyte.
http://purl.obolibrary.org/obo/SCDO_0000643	Insect Repellents	http://purl.obolibrary.org/obo/SCDO_0000709	Malaria Prophylaxis		Substances causing insects to turn away from them or reject them as food.
http://purl.obolibrary.org/obo/SCDO_0000649	Intelligence Scale - Birth to 3.5 years	http://purl.obolibrary.org/obo/NCIT_C122920	Intelligence Scale		A standardized tool designed to assess a child's development as compared to same-age peers. It has components that involve both direct observation and interaction with a child as well as caregiver questionnaires. It consists of five domains (cognitive, motor, language, social-emotional, and adaptive behavior).
http://purl.obolibrary.org/obo/SCDO_0000650	Intentional Drug Misuse AE	http://purl.obolibrary.org/obo/SCDO_0000028	Adverse Drug Event		An adverse drug event that results in the intentional use of a drug in the wrong way (recreationally etc).
http://purl.obolibrary.org/obo/SCDO_0000651	Interrupted Time Series Analysis	http://purl.obolibrary.org/obo/SCDO_0000437	Epidemiologic Studies		A study that uses observations at multiple time points before and after an intervention (the interruption), in an attempt to detect whether the intervention has had an effect significantly greater than any underlying trend over time.
http://purl.obolibrary.org/obo/SCDO_0000653	deprecated-Intracerebral Haemorrhage	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		Intracerebral hemorrhage (ICH) is when blood suddenly bursts into brain tissue, causing damage to the brain.
http://purl.obolibrary.org/obo/SCDO_0000656	Intracranial Hypotension	http://purl.obolibrary.org/obo/HP_0012638	Abnormal Nervous System Physiology		CSF pressure less than 6 cm of H2O in patients with clinical presentation compatible with intracranial hypotension, which are postural headache, nausea, vomiting, neck pain, visual and hearing disturbances, and vertigo. It most commonly results from CSF leaks somewhere along the neuraxis.
http://purl.obolibrary.org/obo/SCDO_0000657	Intraosseous Pressure	http://purl.obolibrary.org/obo/SCDO_0000728	Diagnostic Measurement		The hydrostatic pressure of venous blood in the marrow of bones.
http://purl.obolibrary.org/obo/SCDO_0000665	Ischemia	http://purl.obolibrary.org/obo/HP_0001626	Abnormality of Cardiovascular System		A hypoperfusion of the blood through an organ or tissue caused by a pathologic constriction or obstruction of its blood vessels, or an absence of blood circulation.
http://purl.obolibrary.org/obo/SCDO_0000666	Isoelectric Focusing	http://purl.obolibrary.org/obo/SCDO_0000424	Electrophoresis		Electrophoresis in which a pH gradient is established in a gel medium and proteins migrate until they reach the site (or focus) at which the pH is equal to their isoelectric point.
http://purl.obolibrary.org/obo/SCDO_0000676	Kidney Function Test	http://purl.obolibrary.org/obo/SCDO_0000902	Physiological Assay		Laboratory tests used to evaluate how well the kidneys are working through examination of blood and urine.
http://purl.obolibrary.org/obo/SCDO_0000678	Knowledge about Sickle Cell Disease	http://purl.obolibrary.org/obo/SCDO_0000246	Clinical Competence		Collections of facts, assumptions, beliefs and practices that health professionals hold about the aetiology, pathophysiology, quality management of SCD and related social support systems based on global standards.
http://purl.obolibrary.org/obo/SCDO_0000682	Lactate Dehydrogenase Level	http://purl.obolibrary.org/obo/CMO_0000023	Blood Chemistry Measurement		The level of lactate dehydrogenase, an enzyme released during tissue damage and injury, found in a specified biological specimen.
http://purl.obolibrary.org/obo/SCDO_0000683	Lactate Dehydrogenase Test	http://purl.obolibrary.org/obo/SCDO_0000133	Blood Test		A bioassay to measure levels of lactate dehydrogenase, an enzyme released during tissue damage and injury.
http://purl.obolibrary.org/obo/SCDO_0000689	Lifestyle	http://purl.obolibrary.org/obo/SCDO_0000487	Health Behaviour		Typical way of life or manner of living characteristic of an individual or group. (From APA, Thesaurus of Psychological Index Terms, 8th ed).
http://purl.obolibrary.org/obo/SCDO_0000691	Light Coagulation	http://purl.obolibrary.org/obo/SCDO_0000833	Ophthalmologic Surgical Procedure		The coagulation of tissue by an intense beam of light, including laser (laser coagulation). In the eye it is used in the treatment of retinal detachments, retinal holes, aneurysms, hemorrhages, and malignant and benign neoplasms. (Dictionary of Visual Science, 3d ed)
http://purl.obolibrary.org/obo/SCDO_0000694	Liver Examination	http://purl.obolibrary.org/obo/SCDO_0000898	Physical Examination		Any process carried out to determine the condition of a patient's liver.
http://purl.obolibrary.org/obo/SCDO_0000698	Locus of Control	http://purl.obolibrary.org/obo/SCDO_0000488	Health Beliefs		Personality construct referring to an individual's perception of the locus of events as determined internally by his or her own behaviour versus fate, luck, or external forces.
http://purl.obolibrary.org/obo/SCDO_0000699	Longitudinal Studies	http://purl.obolibrary.org/obo/SCDO_0000437	Epidemiologic Studies		Studies in which variables relating to an individual or group of individuals are assessed over a period of time.
http://purl.obolibrary.org/obo/SCDO_0000702	Lot Quality Assurance Sampling	http://purl.obolibrary.org/obo/SCDO_0300004	Epidemiologic Study Characteristics		A sampling methodology using small sample sizes when conducting surveys in small geographical or population-based areas or lots.
http://purl.obolibrary.org/obo/SCDO_0000704	Lung Volume Measurement	http://purl.obolibrary.org/obo/CMO_0000094	Respiratory System Measurement		Measurement of the amount of air that the lungs may contain at various points in the respiratory cycle.
http://purl.obolibrary.org/obo/SCDO_0000705	Lung Volume Test	http://purl.obolibrary.org/obo/SCDO_0000942	Pulmonary Function Test		Clinical assessment to determine the volume of gas within an individual's lung.
http://purl.obolibrary.org/obo/SCDO_0000709	Malaria Prophylaxis	http://purl.obolibrary.org/obo/SCDO_0000930	Infection Prophylaxis		The use of drugs or other agents to prevent malarial infection. Examples: Proguanil, mefloquine, artesunate, insect repellant, insecticide-treated-bednet.
http://purl.obolibrary.org/obo/SCDO_0000710	Manometer	http://purl.obolibrary.org/obo/SCDO_0000376	Diagnostic Device		An instrument that is used for measuring the pressure of liquids and gases.
http://purl.obolibrary.org/obo/SCDO_0000711	Marital Status of Primary Caregiver	http://purl.obolibrary.org/obo/SCDO_1000157	Quality of Life Related Personal Attribute		The current marital status of the respondent's caregiver (i.e. family member or another individual who takes primary responsibility for the respondent).
http://purl.obolibrary.org/obo/SCDO_0000725	Measure of Frequency of Sickle Cell Pain Episodes	http://purl.obolibrary.org/obo/NCIT_C91105	Clinical or Research Assessment Questionnaire		A questionnaire to capture the frequency of acute pain episodes within a defined time frame due to sickle cell disease (SCD). It includes three self-administered questions from the Cooperative Study of Sickle Cell Disease (CSSCD) that capture number of painful episodes that required visits to the emergency room or hospital or interfered with daily activities.
http://purl.obolibrary.org/obo/SCDO_0000726	Measure of Sickle Cell Stigma (MoSCS)	http://purl.obolibrary.org/obo/SCDO_0000951	Quality of Life and Care Measure		Measure of disease specific stigma based on patient reported outcome measurements that assesses 4 MoSCS factors: Social exclusion, Internalized Stigma, Expected Discrimination and Disclosure concerns. Measure includes stigma scores; perceived disease severity, acute care service utilization, hospital admission levels. N=262.
http://purl.obolibrary.org/obo/SCDO_0000727	Measured Weight	http://purl.obolibrary.org/obo/SCDO_0000152	Body Weight		The weight of the participant in kilograms.
http://purl.obolibrary.org/obo/SCDO_0000737	Medical Outcomes Study (MOS) Social Support Survey	http://purl.obolibrary.org/obo/SCDO_0000951	Quality of Life and Care Measure		The MOS Social Support Survey is a self-administered questionnaire that includes 19 items across four functional support subscales: emotional/informational support (8 items), tangible/instrumental support (4 items), affectionate support (3 items), and positive social interaction (3 items). Each item is scored on a 5-point Likert style scale (1 = None of the Time; 5 = All of the Time) to indicate how often that type of support is available to them. A score for each social support subscale can be computed by averaging across the individual items or by adding scores individual items together. Higher scores indicate more support.
http://purl.obolibrary.org/obo/SCDO_0000738	Medical Records	http://purl.obolibrary.org/obo/SCDO_0000948	Quality of Health Care		Recording of pertinent information concerning patient's illness or illnesses.
http://purl.obolibrary.org/obo/SCDO_0000739	Medication Adherence	http://purl.obolibrary.org/obo/SCDO_0000869	Patient Compliance		Voluntary cooperation of the patient in taking drugs or medicine as prescribed. This includes timing, dosage, and frequency.
http://purl.obolibrary.org/obo/SCDO_0000740	Medication Inventory	http://purl.obolibrary.org/obo/SCDO_1000157	Quality of Life Related Personal Attribute		A record of the type and dosage of all prescription and over-the-counter medications as well as dietary supplements currently being taken by the individual.
http://purl.obolibrary.org/obo/SCDO_0000741	Meditation	http://purl.obolibrary.org/obo/SCDO_0001284	Behaviour Therapy		A state of consciousness in which the individual eliminates environmental stimuli from awareness so that the mind can focus on a single thing, producing a state of relaxation and relief from stress. A wide variety of techniques are used to clear the mind of stressful outside interferences. It includes meditation therapy. (Mosby's Medical, Nursing, and Allied Health Dictionary, 4th ed)
http://purl.obolibrary.org/obo/SCDO_0000743	Membranous Nephropathy	http://purl.obolibrary.org/obo/HP_0002715	Abnormality of the Immune System		A type of glomerulonephropathy characterized by histology with thickening of the basement membrane and deposition of immune complexes in the subepithelial space.
http://purl.obolibrary.org/obo/SCDO_0000746	Mental Health	http://purl.obolibrary.org/obo/NCIT_C17047	Quality of Life		Emotional, psychological, and social well-being of an individual or group.
http://purl.obolibrary.org/obo/SCDO_0000747	Meta-Analysis	http://purl.obolibrary.org/obo/SCDO_0000437	Epidemiologic Studies		Works consisting of studies using a quantitative method of combining the results of independent studies (usually drawn from the published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc. It is often an overview of clinical trials. It is usually called a meta-analysis by the author or sponsoring body and should be differentiated from reviews of literature.
http://purl.obolibrary.org/obo/SCDO_0000748	Metabolic State	http://purl.obolibrary.org/obo/SCDO_0000122	Biological Disease Modifier		The state of the chemical reactions that occur within the cells, tissues, or an organism. These processes include both the biosynthesis (anabolism) and the breakdown (catabolism) of organic materials utilized by the living organism.
http://purl.obolibrary.org/obo/SCDO_0000753	Methemoglobinemia	http://purl.obolibrary.org/obo/OGMS_0000047	Genetic Disorder		The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)
http://purl.obolibrary.org/obo/SCDO_0000754	deprecated Diagnostic Method	http://purl.obolibrary.org/obo/SCDO_1000034	from diagnostics		'Any procedure or test to diagnose a disease or disorder. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000760	Migraine Questionnaire	http://purl.obolibrary.org/obo/NCIT_C91105	Clinical or Research Assessment Questionnaire		A questionnaire to assess migraines and headaches.
http://purl.obolibrary.org/obo/SCDO_0000762	Mobile Radiographic Unit	http://purl.obolibrary.org/obo/OBI_0001138	X-Ray Machine		Transportable radiographic equipment allowing imaging services to be brought to the patient.
http://purl.obolibrary.org/obo/SCDO_0000763	Mobility Limitation	http://purl.obolibrary.org/obo/SCDO_0000900	Physical Functioning		Difficulty moving from place to place or from one position to another without assistance.
http://purl.obolibrary.org/obo/SCDO_0000771	Morphine	http://purl.obolibrary.org/obo/CHEBI_35482	Opioid		The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
http://purl.obolibrary.org/obo/SCDO_0000774	obsolete Multicenter Study	http://purl.obolibrary.org/obo/SCDO_0000941	obsolete Publication Type		'A work that reports on a study executed by several cooperating institutions. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000775	Multicenter Studies as Topic	http://purl.obolibrary.org/obo/SCDO_0300005	Research Characteristics		Works about controlled studies which are planned and carried out by several cooperating institutions to assess certain variables and outcomes in specific patient populations, for example, a multicenter study of congenital anomalies in children.
http://purl.obolibrary.org/obo/SCDO_0000776	Multidimensional Health Locus of Control Scales (MHLC)	http://purl.obolibrary.org/obo/SCDO_0000951	Quality of Life and Care Measure		The multidimensional health locus of control (MHLC) scale is a widely used measure of the factors that people believe exert some measures of control over their health. The MHLC originally developed by Wallston and colleagues contained 3 subscales describing various types of control-related cognitions an individual may have about the current state of his or her health. These were: Internal Health Locus of Control (IHLC), Powerful Others Health Locus of Control (PHLC) and Chance Health Locus of Control (CHLC). Subsequently, a fourth subscale, the God Locus of Health Control (G LHC) scale was developed to assess the extent of an individual's belief that God controls his or her health status was added to the measure. Thus, the expanded MHLC Consists of 4 sub-scales: one Internal and 3 external subscales namely, powerful others, chance and God. Each of the 4 sub-scales has 6 items making a total of 24 items. The two original versions of the MHLC (forms A & B) deal with the general health status whereas the third version (Form C) assesses control-related cognitions about a specific disease state.
http://purl.obolibrary.org/obo/SCDO_0000777	Muscle Atrophy	http://purl.obolibrary.org/obo/SCDO_1000268	Abnormality of the Musculature		The presence of skeletal muscular atrophy, reduction in the muscle bulk.
http://purl.obolibrary.org/obo/SCDO_0000781	Mutation Carrier Screening	http://purl.obolibrary.org/obo/NCIT_C92803	Genetic Screening		The process of identifying carriers/heterozygotes of a genetic mutation that can result in a severe recessive condition. Carrier screening is done using various laboratory techniques.
http://purl.obolibrary.org/obo/SCDO_0000782	MYB	http://purl.obolibrary.org/obo/SCDO_0000810	Non-Globin Gene		This gene encodes a protein with three HTH DNA-binding domains that functions as a transcription regulator. This protein plays an essential role in the regulation of hematopoiesis. This gene may be aberrently expressed or rearranged or undergo translocation in leukemias and lymphomas, and is considered to be an oncogene. Alternative splicing results in multiple transcript variants.
http://purl.obolibrary.org/obo/SCDO_0000787	N-terminal Pro-brain Natriuretic Peptide Test	http://purl.obolibrary.org/obo/SCDO_0000133	Blood Test		A bioassay to determine an individual's level of N-terminal pro-brain natriuretic peptide (NT-proBNP).
http://purl.obolibrary.org/obo/SCDO_0000789	Naloxone	http://purl.obolibrary.org/obo/CHEBI_35482	Opioid		A specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.
http://purl.obolibrary.org/obo/SCDO_0000791	Nasal Decongestants	http://purl.obolibrary.org/obo/CHEBI_23888	Drug		Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)
http://purl.obolibrary.org/obo/SCDO_0000794	obsolete Nephrology	http://purl.obolibrary.org/obo/SCDO_0001208	deprecated Urinary System		'A subspecialty of internal medicine concerned with the anatomy, physiology, and pathology of the kidney. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000796	Nephrotic Syndrome	http://purl.obolibrary.org/obo/HP_0000112	Nephropathy		Nephrotic syndrome is a collection of findings resulting from glomerular dysfunction with an increase in glomerular capillary wall permeability associated with pronounced proteinuria >3.5 g per 24 hours (in children, >40 mg/m2/hr or PCR >2000 mg/g [>200 mg/mmol] or >300 mg/dl or 3+ on urine dipstick) plus hypoalbuminemia (<3gm/dl) and edema.
http://purl.obolibrary.org/obo/SCDO_0000797	Nephrotic Range Proteinuria	http://purl.obolibrary.org/obo/SCDO_0000932	Proteinuria		Severely increased amount of excretion of protein in the urine, defined as 3.5 grams per day or more in adults and 40 mg per meter-squared body surface area per hour in children, or urine protein to creatinine ratio >2000 mg/g [>200 mg/mmol] in children.
http://purl.obolibrary.org/obo/SCDO_0000798	deprecated Nervous System	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		The nervous system is an organ system containing predominantly neuron and glial cells. In bilaterally symmetrical organism, it is arranged in a network of tree-like structures connected to a central body. The main functions of the nervous system are to regulate and control body functions, and to receive sensory input, process this information, and generate behavior.
http://purl.obolibrary.org/obo/SCDO_0000799	Neurocognitive Impairment	http://purl.obolibrary.org/obo/SCDO_0000895	Phenotype of Sickle Cell Disease		An invisible complication of sickle cell anemia (SSA) that defies detection by imaging and other routine diagnostic methods. Impaired neurocognitive function in seemingly neurologically intact patients is not related to vasoocclusion or hemolysis. It is detected by neuropsychiatric and neurobehavioral testing and is associated with anemia and age.
http://purl.obolibrary.org/obo/SCDO_0000801	Neurological Rehabilitation	http://purl.obolibrary.org/obo/SCDO_0000978	Rehabilitation		Physician-supervised programs designed to rehabilitate people with diseases, trauma, or disorders of the nervous system.
http://purl.obolibrary.org/obo/SCDO_0000803	Neonatal Screening for Sickle Cell	http://purl.obolibrary.org/obo/SCDO_0001049	Sickle Cell Disease Screening Test		Testing of neonates to identify those with major sickling diseases.
http://purl.obolibrary.org/obo/SCDO_0000804	NIH Stroke Scale (NIHSS)	http://purl.obolibrary.org/obo/SCDO_0001112	Stroke Impact Measure		A physical assessment of the various symptoms associated with a stroke, consisting of 11 categories. For each category, the test administrator asks the respondent to perform an activity or respond to stimuli. Respondents receive a score for each category based upon their ability to complete the activity or respond to the action. Each score typically ranges from 0 to 3. Each category of the NIHSS is designed to determine the respondent's level of consciousness (LOC), visual, motor, or language ability.
http://purl.obolibrary.org/obo/SCDO_0000807	No-Show Patient	http://purl.obolibrary.org/obo/SCDO_0000869	Patient Compliance		Patients who do not turn up for scheduled healthcare appointments.
http://purl.obolibrary.org/obo/SCDO_0000808	Nocturia	http://purl.obolibrary.org/obo/HP_0000079	Abnormality of the Urinary System		Frequent urination at night that interrupts sleep. It is often associated with outflow obstruction, diabetes mellitus, or bladder inflammation (cystitis).
http://purl.obolibrary.org/obo/SCDO_0000809	Non Opioid	http://purl.obolibrary.org/obo/SCDO_0000050	Analgesic		A subclass of analgesic agents that typically do not bind to opioid receptors and are not addictive. Many non-narcotic analgesics are offered as nonprescription drugs.
http://purl.obolibrary.org/obo/SCDO_0000810	Non-Globin Gene	http://purl.obolibrary.org/obo/NCIT_C16612	Gene		A gene that does not encode a globin family protein.
http://purl.obolibrary.org/obo/SCDO_0000811	Non-Proliferative Sickle Retinopathy	http://purl.obolibrary.org/obo/SCDO_0001067	Sickle Retinopathy		Sickle retinopathy caused by direct damage or remodeling of the small blood vessels supplying the retina secondary to vaso-occlusion and local ischemia.
http://purl.obolibrary.org/obo/SCDO_0000812	Non-specific Acute Lower Respiratory Tract Episode	http://purl.obolibrary.org/obo/HP_0002086	Abnormality of the Respiratory System		Includes acute respiratory episodes with lower respiratory tract signs that do not meet the criteria for other diagnoses. May include episodes which would have been diagnosed as ACS were radiographic facilities available.
http://purl.obolibrary.org/obo/SCDO_0000818	obsolete Observational Study	http://purl.obolibrary.org/obo/SCDO_0000252	obsolete Clinical Study		'A work that reports on the results of a clinical study in which participants may receive diagnostic, therapeutic, or other types of interventions, but the investigator does not assign participants to specific interventions (as in an interventional study). [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000819	Observational Studies as Topic	http://purl.obolibrary.org/obo/SCDO_0000253	Clinical Studies as Topic		Works about clinical studies in which participants may receive diagnostic, therapeutic, or other types of interventions, but the investigator does not assign participants to specific interventions (as in an interventional study).
http://purl.obolibrary.org/obo/SCDO_0000822	Occupational Therapy	http://purl.obolibrary.org/obo/SCDO_0000978	Rehabilitation		Skilled treatment that helps individuals achieve independence in all facets of their lives. It assists in the development of skills needed for independent living.
http://purl.obolibrary.org/obo/SCDO_0000828	Oliguria	http://purl.obolibrary.org/obo/HP_0000077	Abnormality of the Kidney		Low output of urine, defined as an output below 5mL/kg/hr over 6 hours.
http://purl.obolibrary.org/obo/SCDO_0000833	Ophthalmologic Surgical Procedure	http://purl.obolibrary.org/obo/SCDO_0001133	Symptomatic Therapeutics		Surgery performed on the eye or any of its parts.
http://purl.obolibrary.org/obo/SCDO_0000834	Ophthalmoscope	http://purl.obolibrary.org/obo/SCDO_0000376	Diagnostic Device		Device for examining the interior of the eye, permitting the clear visualization of the structures of the eye at any depth.
http://purl.obolibrary.org/obo/SCDO_0000835	Ophthalmoscopy	http://purl.obolibrary.org/obo/NCIT_C38060	Eye Examination		Examination of the interior of the eye with an ophthalmoscope.
http://purl.obolibrary.org/obo/SCDO_0000839	Osteomalacia	http://purl.obolibrary.org/obo/HP_0000924	Abnormality of the Skeletal System		A general term for bone weakness owing to a defect in mineralization of the protein framework known as osteoid. This defective mineralization is mainly caused by lack in vitamin D. Osteomalacia in children is known as rickets.
http://purl.obolibrary.org/obo/SCDO_0000840	Osteomyelitis	http://purl.obolibrary.org/obo/HP_0000924	Abnormality of the Skeletal System		An inflammatory process accompanied by bone destruction and caused by an infecting microorganism.
http://purl.obolibrary.org/obo/SCDO_0000851	Pain	http://purl.obolibrary.org/obo/HP_0025142	Constitutional Symptom		An unpleasant sensory and emotional experience triggered in the nervous system, associated with actual or potential tissue damage, or described in terms of such damage.
http://purl.obolibrary.org/obo/SCDO_0000852	Pain Status	http://purl.obolibrary.org/obo/SCDO_0000900	Physical Functioning		The impact of sickle cell pain on the daily activities of patients. The degree to which pain interferes with their quality of life. This pain is related to the unique features of Sickle Cell Disease.
http://purl.obolibrary.org/obo/SCDO_0000864	Palpation of Liver	http://purl.obolibrary.org/obo/SCDO_0000694	Liver Examination		A method of determining the shape and consistency of the liver by feeling with the fingers or hands.
http://purl.obolibrary.org/obo/SCDO_0000866	Parasite	http://purl.obolibrary.org/obo/OBI_0000925	Infectious Agent		Invertebrate organisms that live on or in another organism (the host), and benefit at the expense of the other. Traditionally excluded from definition of parasites are pathogenic bacteria; fungi; viruses; and plants; though they may live parasitically.
http://purl.obolibrary.org/obo/SCDO_0000869	Patient Compliance	http://purl.obolibrary.org/obo/SCDO_0000746	Mental Health		Voluntary cooperation of the patient in following a prescribed regimen.
http://purl.obolibrary.org/obo/SCDO_0000873	Pediatric Migraine Disability Assessment	http://purl.obolibrary.org/obo/SCDO_0000760	Migraine Questionnaire		A headache disability questionnaire which is completed by the patient and his/her parent and is reviewed with the clinician or study staff. It captures the impact of headaches on school performance (three questions), activities at home (one question on homework or chores), and social and/or sports functions (two questions). It is scored by summing the answers across the six questions. If a range is provided as an answer, either use the high end of the range or prompt for a single answer. The frequency and severity are not scored but can be used for clinical reference.
http://purl.obolibrary.org/obo/SCDO_0000874	Pediatric NIH Stroke Scale (PedNIHSS)	http://purl.obolibrary.org/obo/SCDO_0001112	Stroke Impact Measure		A physical assessment of the various symptoms associated with a stroke, consisting of eleven categories. The PedNIHSS was developed by a panel of pediatric and adult stroke experts and is a modification of the adult NIH stroke scale (NIHSS). Modifications were made to allow individuals age 18 or younger to be assessed and are identified in the PedNIHSS by bold italic text.
http://purl.obolibrary.org/obo/SCDO_0000876	Pediatric School Performance Measure	http://purl.obolibrary.org/obo/SCDO_1000297	Quality of Life and Care Diagnostic Instrument		A questionnaire to assess educational performance and learning accommodations.
http://purl.obolibrary.org/obo/SCDO_0000877	PedsQL Multidimensional Fatigue Scale	http://purl.obolibrary.org/obo/NCIT_C78652	Pediatric Quality of Life Inventory (PedsQL)		A generic symptom-specific instrument to measure fatigue across pediatric populations.
http://purl.obolibrary.org/obo/SCDO_0000881	Penicillin Prophylaxis	http://purl.obolibrary.org/obo/NCIT_C51993	Antibiotic Prophylaxis		Use of penicillin for the prevention of infections with penicillin-susceptible organisms, e.g. Streptococcus pneumoniae.
http://purl.obolibrary.org/obo/SCDO_0000882	Percussion of Liver	http://purl.obolibrary.org/obo/SCDO_0000694	Liver Examination		A method of determining the size of the liver by tapping on the surface of the abdomen.
http://purl.obolibrary.org/obo/SCDO_0000885	Peripheral Oxygen Saturation	http://purl.obolibrary.org/obo/CMO_0001324	Oxygen Saturation		An estimation of the oxygen saturation level usually measured with a pulse oximeter device.
http://purl.obolibrary.org/obo/SCDO_0000895	Phenotype of Sickle Cell Disease	http://purl.obolibrary.org/obo/OGMS_0000028	Disease Phenotype		A (combination of) quality(ies) of some or all sickle cell disease individuals, determined by the interaction of the genetic make-up of these individuals (with regard to sickle cell disease) and their environment.
http://purl.obolibrary.org/obo/SCDO_0000896	Physical Detection Method	http://purl.obolibrary.org/obo/SCDO_0000082	Diagnostic Technique, Method, Test or Assay		The physical method (technology) used to measure / readout the effect caused by a perturbagen in the assay environment.
http://purl.obolibrary.org/obo/SCDO_0000897	Physical Environment	http://purl.obolibrary.org/obo/SCDO_0000435	Environmental Disease Modifier		The part of the human environment that consists of purely physical factors, including the natural environment (such as soil, climate, water supply) and the built environment.
http://purl.obolibrary.org/obo/SCDO_0000898	Physical Examination	http://purl.obolibrary.org/obo/SCDO_0000082	Diagnostic Technique, Method, Test or Assay		Systematic and thorough inspection of the patient for physical signs of disease or abnormality.
http://purl.obolibrary.org/obo/SCDO_0000900	Physical Functioning	http://purl.obolibrary.org/obo/NCIT_C17047	Quality of Life		One's ability to carry out activities that require physical actions, ranging from self-care (activities of daily living) to more complex activities that require a combination of skills, often within a social context. Physical function is inclusive of the term disability and includes the full spectrum of physical functioning from severe impairment to exceptional physical abilities.
http://purl.obolibrary.org/obo/SCDO_0000902	Physiological Assay	http://purl.obolibrary.org/obo/SCDO_0000082	Diagnostic Technique, Method, Test or Assay		An organismal assay designed to capture information pertaining to the organic processes and phenomena of an organism or any of its parts or of a particular bodily process.
http://purl.obolibrary.org/obo/SCDO_0000903	Physiotherapy	http://purl.obolibrary.org/obo/SCDO_0000978	Rehabilitation		A therapeutic intervention that remediates impairments and promotes mobility, function, and quality of life through examination, diagnosis, and physical intervention.
http://purl.obolibrary.org/obo/SCDO_0000905	Pilot Projects	http://purl.obolibrary.org/obo/SCDO_0300004	Epidemiologic Study Characteristics		Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
http://purl.obolibrary.org/obo/SCDO_0000908	Pneumatic Retinopexy	http://purl.obolibrary.org/obo/SCDO_0000833	Ophthalmologic Surgical Procedure		A nonincisional procedure that has become a well-accepted alternative to scleral buckling and vitrectomy for the repair of selected cases of rhegmatogenous retinal detachment.
http://purl.obolibrary.org/obo/SCDO_0000913	Polymerase Chain Reaction	http://purl.obolibrary.org/obo/SCDO_0000448	Genetic Technique		The process in which a DNA polymerase is used to amplify a piece of DNA by in vitro enzymatic replication. As the process progresses, the DNA thus generated is itself used as a template for replication. This sets in motion a chain reaction in which the DNA template is exponentially amplified.
http://purl.obolibrary.org/obo/SCDO_0000917	Pragmatic Clinical Trial	http://purl.obolibrary.org/obo/SCDO_0000965	obsolete Randomized Controlled Trial		'Works about randomized clinical trials that compare interventions in clinical settings and which look at a range of effectiveness outcomes and impacts. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000919	Prenatal Screening for Sickle Cell	http://purl.obolibrary.org/obo/SCDO_0001049	Sickle Cell Disease Screening Test		Prenatal detection of a fetus affected with Sickle Cell Disease using appropriate laboratory techniques. Detection of affected fetuses allows couples to make informed decisions regarding the pregnancy.
http://purl.obolibrary.org/obo/SCDO_0000922	Preventative Therapeutics	http://purl.obolibrary.org/obo/SCDO_0001152	Therapeutics		Activities to prevent Sickle Cell Disease or its complications.
http://purl.obolibrary.org/obo/SCDO_0000923	Priapism	http://purl.obolibrary.org/obo/SCDO_0000954	Quality of Life Related SCD Symptoms and Complications		A prolonged painful erection that may last hours and is not associated with sexual activity. It is seen in patients with sickle cell anemia, advanced malignancy, spinal trauma, and certain drug treatments.
http://purl.obolibrary.org/obo/SCDO_0000924	Primary Healthcare	http://purl.obolibrary.org/obo/SCDO_0000494	Health System		Care which provides integrated, accessible health care services by clinicians who are accountable for addressing a large majority of personal health care needs, developing a sustained partnership with patients, and practicing in the context of family and community.
http://purl.obolibrary.org/obo/SCDO_0000925	Proguanil	http://purl.obolibrary.org/obo/IDOMAL_0000122	Malaria Chemoprophylaxis		A biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent. Cycloguanil stops the malaria parasite, Plasmodium falciparum and Plasmodium vivax, from reproducing once it is in the red blood cells. It does this by inhibiting the enzyme, dihydrofolate reductase, which is involved in the reproduction of the parasite.
http://purl.obolibrary.org/obo/SCDO_0000926	Proliferative Sickle Retinopathy	http://purl.obolibrary.org/obo/SCDO_0001067	Sickle Retinopathy		Sickle retinopathy that involves the upregulation of vascular growth factors due to chronic changes of local hypoxia and ischemia.
http://purl.obolibrary.org/obo/SCDO_0000927	PROMIS Adult Profile 29	http://purl.obolibrary.org/obo/NCIT_C102988	Patient Reported Outcomes Measurement Information System (PROMIS)		This protocol includes 29 self-administered quality of life-type questions from the PROMIS Profile 29 for adults. The quality of life questions include physical function, anxiety, depression, fatigue, sleep disturbance, ability to participate in social roles and activities, and pain intensity over the past 7 days. Each question, except for the pain intensity question, is measured on a 5-point scale.
http://purl.obolibrary.org/obo/SCDO_0000928	PROMIS Pediatric Profile 25	http://purl.obolibrary.org/obo/NCIT_C102988	Patient Reported Outcomes Measurement Information System (PROMIS)		This protocol includes 25 quality of life-type questions relating to physical function mobility, anxiety, depressive symptoms, fatigue, peer relationships, pain interference, and pain intensity over the past 7 days.
http://purl.obolibrary.org/obo/SCDO_0000930	Infection Prophylaxis	http://purl.obolibrary.org/obo/CHEBI_23888	Drug		A planned process that has the objective to reduce the risk of acquiring one or more infections.
http://purl.obolibrary.org/obo/SCDO_0000931	Prospective Studies	http://purl.obolibrary.org/obo/SCDO_0000263	Cohort Studies		Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
http://purl.obolibrary.org/obo/SCDO_0000932	Proteinuria	http://purl.obolibrary.org/obo/HP_0003110	Abnormal Urine Homeostasis		Increased amounts of any protein (including albumin) in the urine - typically more than 300mg in a 24hr period.
http://purl.obolibrary.org/obo/SCDO_0000934	Provider Attitudes Toward Patients with Sickle Cell Disease	http://purl.obolibrary.org/obo/SCDO_0000947	Quality of Care Measure		This is a 17-item scale, separated into 4 subscales with good psychometric properties. Negative Attitudes Scale comprises six items grouped together (Mean=36.5, SD=21.9, Potential range = 0 to 100). Higher scores on this scale indicate an endorsement of more negative views about SCD patients. Positive Attitudes Scale comprises four items grouped together (Mean=45.7, SD=24.3, Potential range = 0 to 100). Higher scores indicate an endorsement of more positive views about SCD patients. Concern Raising Behaviors Scale comprises four items grouped together (Mean = 53.7, SD = 22.0, Potential range = 0 to 100). Higher scores indicate greater endorsement of the belief that certain SCD patient behaviors raise clinician concern that the patient is inappropriately drug-seeking. Red-Flag Behaviors Scale comprises three items grouped together (Mean = 58.7, SD = 22.7, Potential range = 0 to 100). Higher scores on this scale indicate greater endorsement of the belief that certain SCD patient behaviors raise clinician concern about patient drug-seeking.
http://purl.obolibrary.org/obo/SCDO_0000935	Pruritus	http://purl.obolibrary.org/obo/HP_0000961	Cyanosis		Pruritus, or itch, is defined as an unpleasant sensation that provokes the desire to scratch.
http://purl.obolibrary.org/obo/SCDO_0000937	Psychological Stress	http://purl.obolibrary.org/obo/SCDO_0000746	Mental Health		Stress wherein emotional factors predominate.
http://purl.obolibrary.org/obo/SCDO_0000938	Psychosocial Deprivation	http://purl.obolibrary.org/obo/SCDO_0000746	Mental Health		The absence of appropriate stimuli in the physical or social environment which are necessary for the emotional, social, and intellectual development of the individual.
http://purl.obolibrary.org/obo/SCDO_0000940	Psychotherapy	http://purl.obolibrary.org/obo/SCDO_0001129	Supportive Therapeutics		A generic term for the treatment of mental illness or emotional disturbances primarily by verbal or nonverbal communication.
http://purl.obolibrary.org/obo/SCDO_0000941	obsolete Publication Type	http://purl.obolibrary.org/obo/SCDO_1000023	obsolete Evidence Code		'Describes the type of material the article represents (e.g., Review, Clinical Trial, Retracted Publication, Letter); see the PubMed Publication Types, e.g., review[pt]. Publication Types are arranged hierarchically with more specific terms arranged beneath broader terms. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000942	Pulmonary Function Test	http://purl.obolibrary.org/obo/SCDO_0000902	Physiological Assay		Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.
http://purl.obolibrary.org/obo/SCDO_0000943	Pulmonary Hypertension	http://purl.obolibrary.org/obo/HP_0000822	Hypertension		An elevation of mean pulmonary arterial systolic pressure (mPASP) (>20 mmHg at rest or >30 mmHg with exercise). The 6th World Symposium on PH reduced it from >25mmHg to >20mmHg for at rest, but did not adjust the definition for PH with exercise.
http://purl.obolibrary.org/obo/SCDO_0000944	Pulse Oximeter	http://purl.obolibrary.org/obo/SCDO_0000376	Diagnostic Device		A measurement device, usually attached to the earlobe or fingertip, that measures the oxygen saturation of arterial blood.
http://purl.obolibrary.org/obo/SCDO_0000945	Pulse Oximetry (Rest)	http://purl.obolibrary.org/obo/NCIT_C38085	Pulse Oximetry		The application of pulse oximetry to measure a patient's saturation of oxyhemoglobin when the patient is at rest.
http://purl.obolibrary.org/obo/SCDO_0000947	Quality of Care Measure	http://purl.obolibrary.org/obo/SCDO_0000951	Quality of Life and Care Measure		The systemic measurement of the quality of health care that includes a broad set of perfomance measures such as the quality of services and the outcomes analysis for particular diseases and conditions, mortality and morbidity, patient safety, data on maternal and child health, as well as evaluation of quality of diagnosis, care accessibility, implementation of proven evidence-based practices, quality of reporting systems for errors and adverse events, reliability and accessibility of health and health care-related information, and health care organizations infrastructure.
http://purl.obolibrary.org/obo/SCDO_0000948	Quality of Health Care	http://purl.obolibrary.org/obo/SCDO_0000950	Quality of Life and Care		The levels of excellence which characterize the health service or health care provided based on accepted standards of quality.
http://purl.obolibrary.org/obo/SCDO_0000951	Quality of Life and Care Measure	http://purl.obolibrary.org/obo/SCDO_0000950	Quality of Life and Care		A measurement tool that is useful in aiding routine clinical practice with regard to quality of life and/or quality of care.
http://purl.obolibrary.org/obo/SCDO_0000952	Quality of Life in Sickle Cell Disease Measure	http://purl.obolibrary.org/obo/SCDO_1000297	Quality of Life and Care Diagnostic Instrument		A questionnaire to assess the physical, emotional, and social impact of chronic conditions, such as sickle cell disease (SCD).
http://purl.obolibrary.org/obo/SCDO_0000953	Quality of Life Measure	http://purl.obolibrary.org/obo/SCDO_0000951	Quality of Life and Care Measure		A measurement tool with eight potential uses in aiding routine clinical practice. It can be used to prioritise problems, facilitate communication, screen for potential problems, identify preferences, monitor changes or response to treatment, and train new staff. It can also be used in clinical audit and in clinical governance. The first five of these can be used in the clinical encounter, while the last three contribute to training, reviewing care, and improving care in the future.
http://purl.obolibrary.org/obo/SCDO_0000954	Quality of Life Related SCD Symptoms and Complications	http://purl.obolibrary.org/obo/NCIT_C17047	Quality of Life		Sickle cell symptoms where there is evidence of some relation with quality of life.
http://purl.obolibrary.org/obo/SCDO_0000955	Quality-Adjusted Life Year (QALY)	http://purl.obolibrary.org/obo/SCDO_0000951	Quality of Life and Care Measure		QALYs are used primarily to correct a person's life expectancy based on the levels of health-related quality of life they are predicted to experience throughout the course of their life, or part of it.
http://purl.obolibrary.org/obo/SCDO_0000957	obsolete Questionnaire	http://purl.obolibrary.org/obo/SCDO_1000034	from diagnostics		'Collection of data obtained from voluntary subjects. The information usually takes the form of answers to questions, or suggestions. Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000963	Radiography	http://purl.obolibrary.org/obo/OBI_0000185	Imaging Assay		Examination of any part of the body for diagnostic purposes by means of x-rays or gamma rays, recording the image on a sensitized surface (such as photographic film).
http://purl.obolibrary.org/obo/SCDO_0000964	Radionuclide Imaging	http://purl.obolibrary.org/obo/OBI_0000185	Imaging Assay		The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.
http://purl.obolibrary.org/obo/SCDO_0000965	obsolete Randomized Controlled Trial	http://purl.obolibrary.org/obo/SCDO_0000283	obsolete Controlled Clinical Trial		'A work that reports on a clinical trial that involves at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000970	Recovery and Recurrence Questionnaire (RRQ)	http://purl.obolibrary.org/obo/SCDO_0001339	Functionality After Stroke Measure		A questionnaire that assesses recovery and recurrence of stroke in children. It is completed by a parent about their child.
http://purl.obolibrary.org/obo/SCDO_0000972	Recurrent Wheeze in Sickle Cell Disease	http://purl.obolibrary.org/obo/SCDO_0000895	Phenotype of Sickle Cell Disease		Recurrent episodes of wheezing in persons with SCD who have no co-morbid asthma.
http://purl.obolibrary.org/obo/SCDO_0000975	Red Blood Cell Microparticles Level	http://purl.obolibrary.org/obo/CMO_0000023	Blood Chemistry Measurement		The amount of red blood cell derived microparticles in a specific volume of blood.
http://purl.obolibrary.org/obo/SCDO_0000976	Reduced Hemoglobin A	http://purl.obolibrary.org/obo/HP_0020062	Decreased Hemoglobin Concentration		Hemoglobin A (HbA) contains two alpha-globin chains and two beta-globin chains. HbA is normally the main adult hemoglobin, representing about 96-98 percent of all hemoglobin. This term represents a decrease in the proportion of HbA below this limit, and can be seen in various forms of thalassemia.
http://purl.obolibrary.org/obo/SCDO_0000978	Rehabilitation	http://purl.obolibrary.org/obo/SCDO_0001129	Supportive Therapeutics		Restoration of human functions to the maximum degree possible in a person or persons suffering from disease or injury.
http://purl.obolibrary.org/obo/SCDO_0000979	Reincarnation	http://purl.obolibrary.org/obo/SCDO_0000107	Beliefs About Causes of Illness		Reincarnation is the philosophical or religious concept that an aspect of a living being starts a new life in a different physical body or form after each biological death.
http://purl.obolibrary.org/obo/SCDO_0000981	Religion	http://purl.obolibrary.org/obo/NCIT_C19332	Personal Attribute		A set of beliefs concerning the nature, cause, and purpose of the universe, especially when considered as the creation of a superhuman agency. It usually involves devotional and ritual observances and often a moral code for the conduct of human affairs.
http://purl.obolibrary.org/obo/SCDO_0000983	Renal Dialysis	http://purl.obolibrary.org/obo/SCDO_1000004	Renal Replacement Therapy		Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, peritoneal dialysis, and hemodiafiltration.
http://purl.obolibrary.org/obo/SCDO_0000984	Renal Ischemia	http://purl.obolibrary.org/obo/SCDO_1000383	Renal Complication		Inadequate blood flow to one or both kidneys, or nephrons, usually due to functional constriction or actual obstruction of blood vessels.
http://purl.obolibrary.org/obo/SCDO_0000985	Renal Transplant	http://purl.obolibrary.org/obo/SCDO_1000004	Renal Replacement Therapy		The transference of a kidney from one human or animal to another.
http://purl.obolibrary.org/obo/SCDO_0000986	Renal Tubular Acidosis	http://purl.obolibrary.org/obo/HP_0000077	Abnormality of the Kidney		Acidosis owing to malfunction of the kidney tubules with accumulation of metabolic acids and hyperchloremia.
http://purl.obolibrary.org/obo/SCDO_0000987	Reproductive History Diagnostic Instrument	http://purl.obolibrary.org/obo/NCIT_C91105	Clinical or Research Assessment Questionnaire		A questionnaire to assess either male or females' pregnancy history. Females are asked about the number of pregnancies, description of pregnancies and smoking during pregnancy. Males are asked whether they have ever fathered a pregnancy and, if so, the description of the pregnancy.
http://purl.obolibrary.org/obo/SCDO_0000988	deprecated Reproductive System	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		'Anatomical system that has as its parts the organs concerned with reproduction. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000990	obsolete Research Activity	http://purl.obolibrary.org/obo/SCDO_1000031	from personal attribute		'Systematic investigation into a subject in order to discover facts, establish or revise a theory, or develop a plan of action based on the facts discovered. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000993	Respiratory Rate	http://purl.obolibrary.org/obo/CMO_0000094	Respiratory System Measurement		The number of times an organism breathes with the lungs (respiration) per unit time, usually per minute.
http://purl.obolibrary.org/obo/SCDO_0000994	deprecated Respiratory System	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		Lungs and respiratory system of the body.
http://purl.obolibrary.org/obo/SCDO_0001002	Restriction Fragment Length Polymorphism PCR	http://purl.obolibrary.org/obo/SCDO_0000913	Polymerase Chain Reaction		PCR-restriction fragment length polymorphism (RFLP)-based analysis, also known as cleaved amplified polymorphic sequence (CAPS), is a popular technique for genetic analysis. It has been applied for the detection of intraspecies as well as interspecies variation. There exist several techniques that are related with PCR-RFLP and also involve gel electrophoresis including techniques for DNA fingerprinting and expression profiling.
http://purl.obolibrary.org/obo/SCDO_0001004	Reticulocyte Count	http://purl.obolibrary.org/obo/CMO_0000025	Red Blood Cell Count		The number of reticulocytes per unit volume of blood. The values are expressed as a percentage of the erythrocyte count or in the form of an index ("corrected reticulocyte index"), which attempts to account for the number of circulating erythrocytes.
http://purl.obolibrary.org/obo/SCDO_0001005	Reticulocyte Count by Hematology Analyzer	http://purl.obolibrary.org/obo/SCDO_0001004	Reticulocyte Count		A reticulocyte count that was performed with an electronic haematology analyzer.
http://purl.obolibrary.org/obo/SCDO_0001006	Reticulocyte Count by Microsocopy	http://purl.obolibrary.org/obo/SCDO_0001004	Reticulocyte Count		A reticulocyte count that was performed with microscopy.
http://purl.obolibrary.org/obo/SCDO_0001007	Retinal Cryopexy	http://purl.obolibrary.org/obo/SCDO_0000833	Ophthalmologic Surgical Procedure		A procedure that uses intense cold to induce a chorioretinal scar and to destroy retinal or choroidal tissue.
http://purl.obolibrary.org/obo/SCDO_0001008	Retinal Detachment	http://purl.obolibrary.org/obo/HP_0000478	Abnormality of the Eye		Separation of the retina from the choroid and eye wall due to holes in the retina and traction on the retina by vitreous bands and condensed preretinal membranes (usually as sequelae of proliferative sickle retinopathy). Retinal detachment is the most severe complication (Stage V) of proliferative sickle retinopathy.
http://purl.obolibrary.org/obo/SCDO_0001010	Retrospective Studies	http://purl.obolibrary.org/obo/SCDO_0000263	Cohort Studies		Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
http://purl.obolibrary.org/obo/SCDO_0001017	Rural Location	http://purl.obolibrary.org/obo/SCDO_0000496	Healthcare Access		An open swath of land that has few homes or other buildings, and not very many people.
http://purl.obolibrary.org/obo/SCDO_0001019	Salmon Patch Hemorrhage	http://purl.obolibrary.org/obo/HP_0000478	Abnormality of the Eye		Round or oval-shaped intraretinal accumulation of erythrocytes that may be up to 2 mm in diameter. This small intraretinal hematoma is initially red and becomes salmon colored with time.
http://purl.obolibrary.org/obo/SCDO_0001020	Sampling Studies	http://purl.obolibrary.org/obo/SCDO_0000437	Epidemiologic Studies		Studies in which a number of subjects are selected from all subjects in a defined population. Conclusions based on sample results may be attributed only to the population sampled.
http://purl.obolibrary.org/obo/SCDO_0001023	SCD Related Pain	http://purl.obolibrary.org/obo/SCDO_0000954	Quality of Life Related SCD Symptoms and Complications		Pain resulting from the presence of Sickle Cell Disease (SCD). Such pain can be acute, chronic or a mixture of the two.
http://purl.obolibrary.org/obo/SCDO_0001025	Scleral Buckling	http://purl.obolibrary.org/obo/SCDO_0000833	Ophthalmologic Surgical Procedure		An operation for retinal detachment which reduces the size of the globe by indenting the sclera so that it approximates the retina.
http://purl.obolibrary.org/obo/SCDO_0001027	Secondary Healthcare	http://purl.obolibrary.org/obo/SCDO_0000494	Health System		Specialized healthcare delivered as a follow-up or referral from a primary care provider.
http://purl.obolibrary.org/obo/SCDO_0001029	Sedentary Lifestyle	http://purl.obolibrary.org/obo/SCDO_0000689	Lifestyle		Usual level of physical activity that is less than 30 minutes of moderate-intensity activity on most days of the week.
http://purl.obolibrary.org/obo/SCDO_0001035	Self Efficacy	http://purl.obolibrary.org/obo/SCDO_0000286	Coping Skill		Cognitive mechanism based on expectations or beliefs about one's ability to perform actions necessary to produce a given effect.
http://purl.obolibrary.org/obo/SCDO_0001037	Self-Reported Weight	http://purl.obolibrary.org/obo/SCDO_0000152	Body Weight		The weight in kilograms or pounds as reported by the participant.
http://purl.obolibrary.org/obo/SCDO_0001043	Serum HDL Cholesterol Level	http://purl.obolibrary.org/obo/CMO_0000023	Blood Chemistry Measurement		The amount of the HDL cholesterol, the small lipoprotein:cholesterol complex that transports cholesterol out of the arteries and to the liver for reprocessing or excretion, in a specified volume of serum.
http://purl.obolibrary.org/obo/SCDO_0001044	SF-36v2 Health Survey	http://purl.obolibrary.org/obo/SCDO_0000953	Quality of Life Measure		A 36-item instrument for measuring health status and outcomes via patient self-report. It is designed for use in surveys of general and specific populations, health policy evaluations, and clinical practice and research. The SF-36v2 measures the following eight health concepts, which are relevant across age, disease, and treatment groups: physical functioning, role limitations due to physical health problems, bodily pain, general health, vitality (energy/fatigue), social functioning, role limitations due to emotional problems, and mental health (psychological distress and psychological well-being). Both standard (4-week) and acute (1-week) recall versions are available. The survey's standardized scoring system yields a profile of eight health scores and two summary measures (physical and mental health) and a self-evaluated change in health status.
http://purl.obolibrary.org/obo/SCDO_0001047	Sickle Cell Disease Health-Related Stigma Scale (SCD-HRSS)	http://purl.obolibrary.org/obo/SCDO_0000953	Quality of Life Measure		A measure of stigma among adults living with Sickle Cell disease. Focus on; depressive symptoms, pain, assertive communication, satisfaction with pain management experience, and health-related stigma.
http://purl.obolibrary.org/obo/SCDO_0001048	Sickle Cell Disease Pain Burden Interview - Youth	http://purl.obolibrary.org/obo/SCDO_0000953	Quality of Life Measure		The SCPBI-Y is a brief clinical interview designed to assess pain burden for children and adolescents with SCD.
http://purl.obolibrary.org/obo/SCDO_0001050	Sickle Cell Disease Self-Efficacy Scale	http://purl.obolibrary.org/obo/SCDO_1000297	Quality of Life and Care Diagnostic Instrument		A nine-item self-administered questionnaire that measures disease-specific perceptions of the ability to manage day-to-day issues resulting from sickle cell disease (SCD). Items are scores according to a five-point scale ranging from 1 - Not sure at all to 5 - Very sure. Responses from individual items are summed to give an overall score with higher scores indicating greater self-efficacy.
http://purl.obolibrary.org/obo/SCDO_0001051	Variant Sickle Cell Syndrome	http://purl.obolibrary.org/obo/SCDO_1000106	Sickle Cell Disease		A variant form of sickle cell disease that results from inheriting the sickle mutation in combination with another beta-globin gene mutation. These hemoglobinopathies may have different clinical severity compared to the homozygous form of sickle cell disease (HbSS).
http://purl.obolibrary.org/obo/SCDO_0001052	Sickle Cell Pain Management	http://purl.obolibrary.org/obo/SCDO_0001133	Symptomatic Therapeutics		A form of therapy that employs a coordinated and interdisciplinary approach for easing the suffering and improving the quality of life of those experiencing sickle cell related pain.
http://purl.obolibrary.org/obo/SCDO_0001053	Sickle Cell Painful Event	http://purl.obolibrary.org/obo/SCDO_0001023	SCD Related Pain		Pain lasting at least two hours that requires an unscheduled emergency room visit or hospitalization or that disrupts daily activities.
http://purl.obolibrary.org/obo/SCDO_0001054	Sickle Cell Related Cancer	http://purl.obolibrary.org/obo/OBI_1110053	Cancer		A cancer that is almost exclusively associated with sickle cell trait and/or sickle cell disease.
http://purl.obolibrary.org/obo/SCDO_0001055	Sickle Cell Trait	http://purl.obolibrary.org/obo/NCIT_C95534	Hemoglobin Trait		The condition of being heterozygous for hemoglobin S.
http://purl.obolibrary.org/obo/SCDO_0001056	Sickle Cell Disease-S Beta Minus Thalassemia	http://purl.obolibrary.org/obo/NCIT_C95539	Sickle Beta Thalassemia		A mild form of sickle cell thalassemia characterized by the presence of hemoglobin S and a reduced amount of hemoglobin A in the red blood cells. It is characterized by the presence of small red blood cells and mild anemia.
http://purl.obolibrary.org/obo/SCDO_0001059	Sickle Cell Disease-SC	http://purl.obolibrary.org/obo/SCDO_1000163	Compound Heterozygous Sickle Cell Disease		One of the sickle cell disorders characterized by the presence of both hemoglobin S and hemoglobin C. It is similar to, but less severe than sickle cell anemia.
http://purl.obolibrary.org/obo/SCDO_0001062	Sickle Cell Disease-SE	http://purl.obolibrary.org/obo/SCDO_1000163	Compound Heterozygous Sickle Cell Disease		A variant of sickle cell disease due to heterozygosity for hemoglobin S and hemoglobin E mutations, which can cause mild hemolytic anemia.
http://purl.obolibrary.org/obo/SCDO_0001063	Sickle Cell Disease-S/Lepore Boston	http://purl.obolibrary.org/obo/NCIT_C95539	Sickle Beta Thalassemia		Sickle cell-Hb Lepore Boston syndrome is a type of sickle cell disease that differs from homozygous sickle cell disease where both parents carry sickle hemoglobin. In this variant one parent has the sickle cell hemoglobin the second parent has Hb Lepore Boston, the only one of the three Hb Lepore variants described in association with HbS.
http://purl.obolibrary.org/obo/SCDO_0001065	obsolete Sickle Cell-Hemoglobin Other than A,C,D,E,O-Arab	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		'A variant of sickle cell disease in which individuals have atypical hemoglobin molecules called hemoglobin S together with another form of abnormal hemoglobin, other than hemoglobin C,D,E and O-Arab. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0001067	Sickle Retinopathy	http://purl.obolibrary.org/obo/HP_0000478	Abnormality of the Eye		Retinal changes of sickle cell disease that can be either proliferative or non-proliferative. In both cases, the changes are caused by erythrostasis secondary to sickling.
http://purl.obolibrary.org/obo/SCDO_0001068	Sickling Test	http://purl.obolibrary.org/obo/SCDO_1000577	Type of SCD Test		A qualitative screening test for sickling haemoglobins, especially HbS. In the SCT, sodium metabisulfite or sodium dithionate is used to desolubilise haemoglobin S to the crystallised deoxygenated form, which causes the abnormal RBCs to sickle, as detected by light microscopy.
http://purl.obolibrary.org/obo/SCDO_0001069	Sickness Impact Profile (SIP)	http://purl.obolibrary.org/obo/SCDO_0000953	Quality of Life Measure		A generic measure used to evaluate the impact of SCD on both physical and emotional functioning of an affected person. SIP is designed to measure perceived health status and to be used as an outcome measure for evaluation, program planning, and policy formation related to health care. It is designed in such a way as to reflect sensitivity to changes and/or differences in health status and to be applicable across a broad range of types and severities of the SCD illness, as well as different demographic and cultural groups.
http://purl.obolibrary.org/obo/SCDO_0001070	deprecated Skin	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		'The bodily system consisting of the skin and its associated structures, such as the hair, nails, sweat glands, and sebaceous glands. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0001073	Skin Rash	http://purl.obolibrary.org/obo/HP_0011122	Abnormality of Skin Physiology		An abnormal change in skin color, appearance, or texture.
http://purl.obolibrary.org/obo/SCDO_0001075	Sleep Breathing Disorder	http://purl.obolibrary.org/obo/HP_0000708	Behavioural Abnormality		An intrinsic sleep disorder characterized by breathing abnormalities.
http://purl.obolibrary.org/obo/SCDO_0001076	Sleep Disorders Screener - Adult	http://purl.obolibrary.org/obo/SCDO_1000348	Sleep Disorders Screener		An interviewer-administered questionnaire which captures routine sleep schedule, sleep deprivation, morningness-eveningness, insomnia, narcolepsy, cataplexy and associated distress.
http://purl.obolibrary.org/obo/SCDO_0001077	Slit Lamp	http://purl.obolibrary.org/obo/SCDO_0000376	Diagnostic Device		A microscope with a light source that can be projected into a linear beam. It allows cross-sectional viewing of the aqueous humor; conjuncteiva; cornea; eyelids; iris; and lens of the eye.
http://purl.obolibrary.org/obo/SCDO_0001079	Smoking	http://purl.obolibrary.org/obo/SCDO_0000487	Health Behaviour		Inhaling and exhaling the smoke of burning tobacco (Cigar, Cigarette, Hookah, Pipe, Smoking, Waterpipe).
http://purl.obolibrary.org/obo/SCDO_0001080	Smoking Cessation	http://purl.obolibrary.org/obo/SCDO_0001159	Tobacco Use Cessation		Discontinuing the habit of smoking.
http://purl.obolibrary.org/obo/SCDO_0001082	Social Environment	http://purl.obolibrary.org/obo/SCDO_0000435	Environmental Disease Modifier		The aggregate of social and cultural institutions, forms, patterns, and processes that influence the life of an individual or community.
http://purl.obolibrary.org/obo/SCDO_0001083	Social Functioning	http://purl.obolibrary.org/obo/NCIT_C17047	Quality of Life		Social functioning defines an individual's interactions with their environment and the ability to fulfill their role within such environments as work, social activities, and relationships with partners and family.
http://purl.obolibrary.org/obo/SCDO_0001084	Social Isolation	http://purl.obolibrary.org/obo/SCDO_0001083	Social Functioning		The separation of individuals or groups resulting in the lack of or minimizing of social contact and/or communication. This separation may be accomplished by physical separation, by social barriers and by psychological mechanisms. In the latter, there may be interaction but no real communication.
http://purl.obolibrary.org/obo/SCDO_0001085	Social Role	http://purl.obolibrary.org/obo/SCDO_0001083	Social Functioning		A role that is ascribed to individuals in a community.
http://purl.obolibrary.org/obo/SCDO_0001086	Social Role Fulfillment	http://purl.obolibrary.org/obo/SCDO_0001083	Social Functioning		An extent/ degree to which an individual fulfills the expectations of his/her social role.
http://purl.obolibrary.org/obo/SCDO_0001087	Social Skill	http://purl.obolibrary.org/obo/SCDO_0001083	Social Functioning		The personal set of abilities required to successfully interact and communicate with others, both verbally and non-verbally through gestures, body language and personal appearance.
http://purl.obolibrary.org/obo/SCDO_0001088	Social Support	http://purl.obolibrary.org/obo/SCDO_0001083	Social Functioning		Support systems that provide assistance and encouragement to individuals with physical or emotional disabilities in order that they may better cope. Informal social support is usually provided by friends, relatives, or peers, while formal assistance is provided by churches, groups, etc.
http://purl.obolibrary.org/obo/SCDO_0001089	Social Values	http://purl.obolibrary.org/obo/SCDO_0000299	Culture		Abstract standards or empirical variables in social life which are believed to be important and/or desirable.
http://purl.obolibrary.org/obo/SCDO_0001090	Socioeconomic Factors	http://purl.obolibrary.org/obo/SCDO_0001082	Social Environment		Social and economic factors that characterize the individual or group within the social structure.
http://purl.obolibrary.org/obo/SCDO_0001091	Socioeconomic Status	http://purl.obolibrary.org/obo/SCDO_0001090	Socioeconomic Factors		The combination of one's social class and income level. Includes socioeconomic differences between individuals or groups.
http://purl.obolibrary.org/obo/SCDO_0001092	Solubility Test	http://purl.obolibrary.org/obo/SCDO_1000577	Type of SCD Test		A basic first line test that looks for the presence of abnormal Hemoglobin S in a blood sample. Sodium metabisulfite is added to the blood sample which causes Hb S polymerisation and sickling of red blood cells if Hb S is present. A positive result means that a person has either Sickle Cell Disease or Sickle Cell Trait. Confirmatory tests are needed to distinguish which form of SCD the patient has.
http://purl.obolibrary.org/obo/SCDO_0001097	Sphygmomanometer	http://purl.obolibrary.org/obo/SCDO_0000710	Manometer		Instruments for measuring arterial blood pressure consisting of an inflatable cuff, inflating bulb, and a gauge showing the blood pressure.
http://purl.obolibrary.org/obo/SCDO_0001098	Spirituality	http://purl.obolibrary.org/obo/SCDO_0000299	Culture		Sensitivity or attachment to religious values, or to things of the spirit as opposed to material or worldly interests.
http://purl.obolibrary.org/obo/SCDO_0001099	Spirometer	http://purl.obolibrary.org/obo/SCDO_0000376	Diagnostic Device		A spirometer is an apparatus for measuring the volume of air inspired and expired by the lungs. It is a precision differential pressure transducer for the measurements of respiration flow rates. The spirometer records the amount of air and the rate of air that is breathed in and out over a specified period of time.
http://purl.obolibrary.org/obo/SCDO_0001105	Steroid-Resistant Nephrotic Syndrome	http://purl.obolibrary.org/obo/SCDO_0000796	Nephrotic Syndrome		A form of nephrotic syndrome that does not respond to treatment with steroid medication after 8 weeks, specifically in children.
http://purl.obolibrary.org/obo/SCDO_0001107	Stigma	http://purl.obolibrary.org/obo/NCIT_C17047	Quality of Life		A perceived attribute that is deeply discrediting and is considered to be a violation of social norms.
http://purl.obolibrary.org/obo/SCDO_0001108	Stigmatization	http://purl.obolibrary.org/obo/NCIT_C17047	Quality of Life		An oversimplified perception or conception, especially or persons, social groups, etc.
http://purl.obolibrary.org/obo/SCDO_0001112	Stroke Impact Measure	http://purl.obolibrary.org/obo/SCDO_1000297	Quality of Life and Care Diagnostic Instrument		This measure is a physical assessment to determine neurological deficits due to a stroke.
http://purl.obolibrary.org/obo/SCDO_0001113	Stroke Impact Scale (SIS)	http://purl.obolibrary.org/obo/SCDO_0001339	Functionality After Stroke Measure		This questionnaire includes 59 proxy- or self-report items in 8 domains that assess multidimensional stroke outcomes in adults.
http://purl.obolibrary.org/obo/SCDO_0001114	Stroke Risk Test in Children with Sickle Cell Disease	http://purl.obolibrary.org/obo/NCIT_C154865	Cerebral Blood Flow Assay		A clinical test to measure the blood flow velocities in intracranial arteries. Elevated intracranial arterial blood flow rates are indicative of expanding vessel lesions and a subsequent increased risk of stroke.
http://purl.obolibrary.org/obo/SCDO_0001117	Stuttering Priapism	http://purl.obolibrary.org/obo/SCDO_0000923	Priapism		The occurrence of multiple self-limited episodes of unwanted, often painful erections lasting <4 hours.
http://purl.obolibrary.org/obo/SCDO_0001120	Substance Use History	http://purl.obolibrary.org/obo/NCIT_C18772	Personal Medical History		Assessment with the goal to obtain a relevant drug and alcohol history and perform a physical examination in order to establish whether there is a diagnosis of a substance use disorder.
http://purl.obolibrary.org/obo/SCDO_0001121	Substances - Lifetime Use	http://purl.obolibrary.org/obo/SCDO_1000318	Diagnostic Instrument Measurement		An indication of whether the respondent has ever used a drug during his or her entire life.
http://purl.obolibrary.org/obo/SCDO_0001122	Suicidal Thoughts	http://purl.obolibrary.org/obo/SCDO_0000360	Depression		Frequent thinking about or preoccupation with killing oneself.
http://purl.obolibrary.org/obo/SCDO_0001123	Support Group	http://purl.obolibrary.org/obo/SCDO_0001083	Social Functioning		Organizations which provide an environment encouraging social interactions through group activities or individual relationships especially for the purpose of rehabilitating or supporting patients, individuals with common health problems, or the elderly. They include therapeutic social clubs.
http://purl.obolibrary.org/obo/SCDO_0001129	Supportive Therapeutics	http://purl.obolibrary.org/obo/SCDO_0001152	Therapeutics		Measures aimed at providing appropriate supportive and rehabilitative services to minimize morbidity and maximize quality of life after a long-term disease or injury is present.
http://purl.obolibrary.org/obo/SCDO_0001132	Sustained and Selective Attention Diagnostic Instrument	http://purl.obolibrary.org/obo/NCIT_C91105	Clinical or Research Assessment Questionnaire		A computerized test for the assessment of visual attention problems in individuals ages 8 years old and older.
http://purl.obolibrary.org/obo/SCDO_0001133	Symptomatic Therapeutics	http://purl.obolibrary.org/obo/SCDO_0001152	Therapeutics		Therapeutics that ease the symptoms without addressing the basic cause of the disease.
http://purl.obolibrary.org/obo/SCDO_0001136	deprecated Systemic	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		'Affecting a number of tissues relating to the entire organism as distinguished from and of its individual parts. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0001140	Tertiary Healthcare	http://purl.obolibrary.org/obo/SCDO_0000494	Health System		Care of a highly technical and specialized nature, provided in a medical center, usually one affiliated with a university, for patients with unusually severe, complex, or uncommon health problems.
http://purl.obolibrary.org/obo/SCDO_0001141	Test of Functional Health Literacy in Adults (TOFHLA)	http://purl.obolibrary.org/obo/SCDO_0000951	Quality of Life and Care Measure		The Test of Functional Health Literacy Assessment (TOFHLA) assesses a patient's level of comprehension of health-related material. It is available in a full-format (a 22-minute test, with 50 reading comprehension items in three passages and 17 numeracy items), an abbreviated format (a 12-minute test, with 36 reading comprehension items in two passages and four numeracy items) and a shortened version (the S-TOFHLA, a 7-minute test, with 36 reading comprehension items in 2 passages.). The passages on the S-TOFHLA use a modified Cloze procedure where every fifth to seventh word is omitted and subjects select the correct word from among a set of four options. The passages contain information about an upper gastrointestinal tract x-ray procedure, and the "Rights and Responsibilities" section from a Medicaid application, and have Gunning-Fox readability indices of fourth and tenth grade, respectively. In early developmental studies, the reading comprehension passages in the S-TOFHLA had a reliability coefficient (Cronbach's alpha) of 0.97 and correlation with the Rapid Estimate of Adult Literacy in Medicine (REALM) of 0.81. Each selection is scored a "1" for correct or a "0" for incorrect and scores are summed over items to create a total score. The 36-point scale of the S-TOFHLA is divided into three categories of functional literacy: inadequate (0-16), adequate (17-22) and functional (23-36).
http://purl.obolibrary.org/obo/SCDO_0001146	The Duke Religion Index (DUREL)	http://purl.obolibrary.org/obo/SCDO_0000953	Quality of Life Measure		The Duke Religion Index (DUREL) is a five item scale which measures religiosity in three areas: organizational religiosity (OR), non-organizational religiosity (NOR), and intrinsic religiosity. Two of the questions were derived from large epidemiologic studies and have been shown to have a strong predictive value for many health outcomes. OR has been related to less depression, more social support, better physical health, lower resource utilization, and lower mortality. NOR has been shown to be related to poorer physical health, and greater social support. The other three items were taken from the Hoge 10- item religiosity scale (Hodge et al 1972). The DUREL has high test-retest reliability (intra-class correlation = 0.91), high internal consistency (Cronbach's alpha's = 0.78--0.91).
http://purl.obolibrary.org/obo/SCDO_0001150	Therapeutic Device	http://purl.obolibrary.org/obo/SCDO_0001152	Therapeutics		A medical device used to prevent and treat medical conditions, or to alleviate pain or injury.
http://purl.obolibrary.org/obo/SCDO_0001151	Therapeutic Irrigation	http://purl.obolibrary.org/obo/SCDO_0001129	Supportive Therapeutics		The washing of a body cavity or surface by flowing water or solution for therapy or diagnosis.
http://purl.obolibrary.org/obo/SCDO_0001152	Therapeutics	http://purl.obolibrary.org/obo/SCDO_0001000	SCDO		Procedures, agents or devices concerned with the remedial treatment or prevention of diseases.
http://purl.obolibrary.org/obo/SCDO_0001158	Indel Mutation	http://purl.obolibrary.org/obo/IDOMAL_50000026	Mutation		A mutation named with the blend of insertion and deletion. It refers to a length difference between two alleles where it is unknowable if the difference was originally caused by a sequence insertion or by a sequence deletion. If the number of nucleotides in the insertion/deletion is not divisible by three, and it occurs in a protein coding region, it is also a frameshift mutation.
http://purl.obolibrary.org/obo/SCDO_0001159	Tobacco Use Cessation	http://purl.obolibrary.org/obo/SCDO_0000487	Health Behaviour		Ending the tobacco habits of smoking, chewing, or snuff use.
http://purl.obolibrary.org/obo/SCDO_0001164	Traditional Healer	http://purl.obolibrary.org/obo/SCDO_0000108	Beliefs About Remedies and Treatment		A person who practices the art of healing using traditional medicine, a system of medicine based on cultural beliefs and practices handed down from generation to generation. The concept includes mystical and magical rituals (spiritual therapies); phytotherapy (plant therapy) and other treatments which may not be explained by modern medicine.
http://purl.obolibrary.org/obo/SCDO_0001165	Trail Making Test	http://purl.obolibrary.org/obo/SCDO_0001304	Executive Function Measure		An interviewer-administered, two-part test that requires the respondent to organize numerical and alphabetical sequences that are randomly distributed on a piece of paper. The protocol includes instructions for correcting mistakes and instructions for scoring based on speed and accuracy.
http://purl.obolibrary.org/obo/SCDO_0001166	Transcranial Doppler Ultrasonography	http://purl.obolibrary.org/obo/NCIT_C154865	Cerebral Blood Flow Assay		A non-invasive technique using ultrasound for the measurement of cerebrovascular hemodynamics, particularly cerebral blood flow velocity and cerebral collateral flow. With a high-intensity, low-frequency pulse probe, the intracranial arteries may be studied transtemporally, transorbitally, or from below the foramen magnum.
http://purl.obolibrary.org/obo/SCDO_0001167	Transcutaneous Electrical Nerve Stimulation	http://purl.obolibrary.org/obo/SCDO_0000049	Analgesia		The use of specifically placed small electrodes to deliver electrical impulses across the skin to relieve pain. It is used less frequently to produce anesthesia.
http://purl.obolibrary.org/obo/SCDO_0001168	Transient Monocular Blindness	http://purl.obolibrary.org/obo/HP_0000618	Blindness		Temporary loss of vision in one eye due to a lack of blood flow to the retina.
http://purl.obolibrary.org/obo/SCDO_0001197	obsolete Twin Study	http://purl.obolibrary.org/obo/SCDO_0000941	obsolete Publication Type		'Work consisting of reporting using a method of detecting genetic causes in human traits and genetic factors in behavior using sets of twins. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0001198	Twin Studies as Topic	http://purl.obolibrary.org/obo/SCDO_0300004	Epidemiologic Study Characteristics		Works about methods of detecting genetic etiology in human traits. The basic premise of twin studies is that monozygotic twins carry identical genes, while zygotic twins are genetically no more similar than two siblings born after separate pregnancies. (Last, J.M., A Dictionary of Epidemiology, 2d ed)
http://purl.obolibrary.org/obo/SCDO_0001200	UGT1A1	http://purl.obolibrary.org/obo/SCDO_0000810	Non-Globin Gene		This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.
http://purl.obolibrary.org/obo/SCDO_0001204	Urban Location	http://purl.obolibrary.org/obo/SCDO_0000496	Healthcare Access		The region surrounding a city. Most inhabitants of urban areas have nonagricultural jobs. Urban areas are very developed, meaning there is a density of human structures such as houses, commercial buildings, roads, bridges, and railways.
http://purl.obolibrary.org/obo/SCDO_0001205	Urinary Albumin Test	http://purl.obolibrary.org/obo/SCDO_0000676	Kidney Function Test		A bioassay to measure urine concentration of albumin, which is produced by the liver and is the most abundant protein in the blood.
http://purl.obolibrary.org/obo/SCDO_0001207	Urinary Protein Measurement	http://purl.obolibrary.org/obo/CMO_0000256	Urine Measurement		Any measurement of protein present in urine.
http://purl.obolibrary.org/obo/SCDO_0001208	deprecated Urinary System	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		The organs and passageways concerned with the production and excretion of urine, including the kidneys, ureters, urinary bladder, and urethra.
http://purl.obolibrary.org/obo/SCDO_0001209	Urine Albumin Concentration	http://purl.obolibrary.org/obo/SCDO_0001207	Urinary Protein Measurement		The amount of albumin in a specified volume of urine.
http://purl.obolibrary.org/obo/SCDO_0001210	Urine Albumin Excretion Rate	http://purl.obolibrary.org/obo/SCDO_0001207	Urinary Protein Measurement		The amount of albumin excreted into the urine within a specified period of time.
http://purl.obolibrary.org/obo/SCDO_0001212	Urine Albumin-Creatinine Ratio	http://purl.obolibrary.org/obo/SCDO_0001207	Urinary Protein Measurement		A comparison of urine microalbumin, that is, a level of albumin in the urine which is above normal but not detectable with routine protein testing, to the amount of creatinine in a specified volume of urine. Often expressed as albumin concentration divided by creatinine concentration times 1000 mg per gram.
http://purl.obolibrary.org/obo/SCDO_0001213	Urine Creatinine Concentration	http://purl.obolibrary.org/obo/CMO_0000256	Urine Measurement		The concentration of creatinine in a urine specimen.
http://purl.obolibrary.org/obo/SCDO_0001215	Urine Protein Sulfosalicylic Acid Precipitation Test	http://purl.obolibrary.org/obo/SCDO_0000120	Biochemical Assay		A method in which sulfosalicylic acid (that is, the SSA reagent) is added to a small and equal volume of clear urine. The acidification causes precipitation of protein in the sample (seen as increasing turbidity), which can be subjectively quantitated visually or more precisely quantitated using photometry.
http://purl.obolibrary.org/obo/SCDO_0001218	obsolete Urology	http://purl.obolibrary.org/obo/SCDO_0001208	deprecated Urinary System		The medical specialty concerned with the study, diagnosis, and treatment of diseases of the genitourinary tract.
http://purl.obolibrary.org/obo/SCDO_0001223	Validation Studies	http://purl.obolibrary.org/obo/SCDO_0300005	Research Characteristics		Works consisting of research using processes by which the reliability and relevance of a procedure for a specific purpose are established.
http://purl.obolibrary.org/obo/SCDO_0001224	Vaping	http://purl.obolibrary.org/obo/SCDO_0001079	Smoking		Smoking vapors produced from electronic nicotene delivery systems.
http://purl.obolibrary.org/obo/SCDO_0001228	Endothelial Function Test	http://purl.obolibrary.org/obo/SCDO_0000902	Physiological Assay		A measure of vascular endothelial cell response to stimulation, for example, by vasoactive substances released by or those that interact with the vascular endothelium.
http://purl.obolibrary.org/obo/SCDO_0001229	Vaso-Occlusive Crisis	http://purl.obolibrary.org/obo/SCDO_0001023	SCD Related Pain		Pain resulting from tissue ischemia as a result of blockage of blood vessels, occurring in a variety of vascular beds, but most commonly in the bone or bone marrow and requiring analgesic medication.
http://purl.obolibrary.org/obo/SCDO_0001230	Venipuncture	http://purl.obolibrary.org/obo/SCDO_0000082	Diagnostic Technique, Method, Test or Assay		Extraction of blood from a vein using a needle. In human, the basilic, cephalic and median cubital veins are most commonly used as well as the femoral vein.
http://purl.obolibrary.org/obo/SCDO_0001232	Vineland Adaptive Behavior Scales, Second Edition (Vineland-II)	http://purl.obolibrary.org/obo/SCDO_1000297	Quality of Life and Care Diagnostic Instrument		A parent or caregiver questionnaire administered as part of a structured interview that measures day-to-day performance on communication, daily living, socialization, and motor skills. Standard scores can be derived for communication, daily living, socialization, and motor skills subtests or combined to create an Adaptive Behavior Composite (ABC).
http://purl.obolibrary.org/obo/SCDO_0001234	Virus	http://purl.obolibrary.org/obo/OBI_0000925	Infectious Agent		Minute infectious agents whose genomes are composed of DNA or RNA, but not both. They are characterized by a lack of independent metabolism and the inability to replicate outside living host cells.
http://purl.obolibrary.org/obo/SCDO_0001237	Vitrectomy	http://purl.obolibrary.org/obo/SCDO_0000833	Ophthalmologic Surgical Procedure		Removal of the whole or part of the vitreous body in treating endophthalmitis, diabetic retinopathy, retinal detachment, intraocular foreign bodies, and some types of glaucoma.
http://purl.obolibrary.org/obo/SCDO_0001240	Western Blot	http://purl.obolibrary.org/obo/SCDO_0000424	Electrophoresis		Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
http://purl.obolibrary.org/obo/SCDO_0001241	Wheezing Episode with Co-Morbid Asthma	http://purl.obolibrary.org/obo/SCDO_0000895	Phenotype of Sickle Cell Disease		An acute onset of wheezing in a person with SCD and co-morbid asthma.
http://purl.obolibrary.org/obo/SCDO_0001246	Witchcraft	http://purl.obolibrary.org/obo/SCDO_0000107	Beliefs About Causes of Illness		An act of employing sorcery (the use of power gained from the assistance or control of spirits), especially with malevolent intent, and the exercise of supernatural powers and alleged intercourse with the devil or a familiar. (From Webster, 3rd Ed).
http://purl.obolibrary.org/obo/SCDO_0001247	World Health Organisation Quality of Life Instrument (WHOQOL)	http://purl.obolibrary.org/obo/SCDO_0000953	Quality of Life Measure		The WHOQOL is a quality of life assessment developed by the WHOQOL Group with fifteen international field centres, simultaneously, in an attempt to develop a quality of life assessment that would be applicable cross-culturally.
http://purl.obolibrary.org/obo/SCDO_0001250	X-Ray Image of Chest	http://purl.obolibrary.org/obo/SCDO_0001249	X-Ray Image		The visual output that an X-ray machine produces when imaging the chest.
http://purl.obolibrary.org/obo/SCDO_0001252	X-Ray Therapy	http://purl.obolibrary.org/obo/SCDO_0001129	Supportive Therapeutics		Medical treatment involving the use of controlled amounts of X-Rays.
http://purl.obolibrary.org/obo/SCDO_0001253	X-Rays	http://purl.obolibrary.org/obo/OBI_0001138	X-Ray Machine		Penetrating, high-energy electromagnetic radiation emitted when the inner orbital electrons of an atom are excited and release radiant energy. X-ray wavelengths range from 1 pm to 10 nm. Hard X-rays are the higher energy, shorter wavelength X-rays. Soft x-rays or Grenz rays are less energetic and longer in wavelength. The short wavelength end of the X-ray spectrum overlaps the gamma rays wavelength range. The distinction between gamma rays and X-rays is based on their radiation source.
http://purl.obolibrary.org/obo/SCDO_0001267	EuroQol Five Dimensions Questionnaire (EQ-5D)	http://purl.obolibrary.org/obo/SCDO_0000951	Quality of Life and Care Measure		The EQ-5D is a widely-used generic instrument for describing health-related quality of life states in five dimensions scored from 1 to 3 or 1 to 5, and a visual analogue scale to record self-rated health state from 0 to100. These provide a simple descriptive profile and a single index value for health status. The EQ-5D can also be used to calculate health utilities and determine the quality-adjusted life years associated with a health state. There is also a youth version (EQ-5D-Y).
http://purl.obolibrary.org/obo/SCDO_0001268	Functional Assessment of Chronic Illness Therapy-Spirituality (FACIT-Sp) Scale	http://purl.obolibrary.org/obo/SCDO_0000953	Quality of Life Measure		The FACIT-Sp is a 12-item measure that asks participants to indicate how true various statements are about them on a Likert scale of 0 ("not at all") to 4 ("very much"). Responses on the FACIT-Sp are summed to create a total score, ranging from 0 to 48, with higher scores representing higher levels of spirituality.
http://purl.obolibrary.org/obo/SCDO_0001284	Behaviour Therapy	http://purl.obolibrary.org/obo/SCDO_0000940	Psychotherapy		The application of modern theories of learning and conditioning in the treatment of behavior disorders.
http://purl.obolibrary.org/obo/SCDO_0001288	Cluster Headache	http://purl.obolibrary.org/obo/SCDO_1000000	Acute Phenotype		A primary headache disorder that is characterized by severe, strictly unilateral pain which is orbital, supraorbital, temporal or in any combination of these sites, lasting 15-180 min. occurring 1 to 8 times a day. The attacks are associated with one or more of the following, all of which are ipsilateral: conjunctival injection, lacrimation, nasal congestion, rhinorrhea, facial sweating, eyelid edema, and miosis.
http://purl.obolibrary.org/obo/SCDO_0001292	D57.00 Hb-SS disease with crisis, unspecified	http://purl.obolibrary.org/obo/SCDO_0000312	D57.0 Hb-SS disease with crisis		Broad term used to describe several different acute conditions occurring with sickle cell disease, including aplastic crisis, hemolytic crisis, and vasoocclusive crisis.
http://purl.obolibrary.org/obo/SCDO_0001295	Electrocardiograph	http://purl.obolibrary.org/obo/SCDO_0000376	Diagnostic Device		An instrument used in the detection and diagnosis of heart abnormalities that measures electrical potentials on the body surface and generates a record of the electrical currents associated with heart muscle activity.
http://purl.obolibrary.org/obo/SCDO_0001296	Erythrocyte Transfusion	http://purl.obolibrary.org/obo/SCDO_0000138	Blood Component Transfusion		The transfer of erythrocytes from a donor to a recipient or reinfusion to the donor.
http://purl.obolibrary.org/obo/SCDO_0001299	Evaluation Studies	http://purl.obolibrary.org/obo/SCDO_0300005	Research Characteristics		Works consisting of studies determining the effectiveness or utility of processes, personnel, and equipment.
http://purl.obolibrary.org/obo/SCDO_0001303	Exchange Transfusion, Whole Blood	http://purl.obolibrary.org/obo/SCDO_0000147	Blood Transfusion		Repetitive withdrawal of small amounts of blood and replacement with donor blood until a large proportion of the blood volume has been exchanged. Used in treatment of fetal erythroblastosis, hepatic coma, sickle cell anemia, disseminated intravascular coagulation, septicemia, burns, thrombotic thrombopenic purpura, and fulminant malaria.
http://purl.obolibrary.org/obo/SCDO_0001304	Executive Function Measure	http://purl.obolibrary.org/obo/NCIT_C91105	Clinical or Research Assessment Questionnaire		An interviewer-administered test to measure a respondent's system of high-level cognitive functions such as abstract thinking, rule acquisition, cognitive flexibility, and goal-oriented behavior.
http://purl.obolibrary.org/obo/SCDO_0001312	deprecated Eye	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		The organ of vision that consists of the eyeball and the optic nerve.
http://purl.obolibrary.org/obo/SCDO_0001316	obsolete Facial Paralysis	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		Facial paralysis is loss of facial movement because of nerve damage.
http://purl.obolibrary.org/obo/SCDO_0001319	Fatigue	http://purl.obolibrary.org/obo/HP_0025142	Constitutional Symptom		Inability to function due to tiredness related to sickle cell disease.
http://purl.obolibrary.org/obo/SCDO_0001320	Feasibility Studies	http://purl.obolibrary.org/obo/SCDO_0300004	Epidemiologic Study Characteristics		Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
http://purl.obolibrary.org/obo/SCDO_0001321	Fentanyl	http://purl.obolibrary.org/obo/CHEBI_35482	Opioid		A potent narcotic analgesic, abuse of which leads to habituation or addiction. It is primarily a mu-opioid agonist. Fentanyl is also used as an adjunct to general anesthetics, and as an anesthetic for induction and maintenance.
http://purl.obolibrary.org/obo/SCDO_0001322	Serum Ferritin Test	http://purl.obolibrary.org/obo/SCDO_0000133	Blood Test		A bioassay to measure the serum concentration of ferritin (i.e., iron).
http://purl.obolibrary.org/obo/SCDO_0001323	Serum Ferritin Level	http://purl.obolibrary.org/obo/CMO_0000023	Blood Chemistry Measurement		The amount of ferritin found in a specified volume of serum.
http://purl.obolibrary.org/obo/SCDO_0001325	Flow Cytometer	http://purl.obolibrary.org/obo/SCDO_0000376	Diagnostic Device		An instrument which is used to count and sort microscopic particles suspended in a buffer. This instrument consists of a flow cell, at least one lamp or laser, a variable number of emission detectors or photomultipliers, a system that converts analog signals to digital, and a computer to run the system and collect and analyze the data output.
http://purl.obolibrary.org/obo/SCDO_0001326	Flow Cytometry	http://purl.obolibrary.org/obo/SCDO_0000896	Physical Detection Method		Flow cytometry uses the principles of light scattering and fluorescence from fluorochrome molecules to generate specific multi-parameter data from particles and cells in the size range of 0.5um to 40um diameter.
http://purl.obolibrary.org/obo/SCDO_0001327	Fluorescein Angiography	http://purl.obolibrary.org/obo/OBI_0000185	Imaging Assay		Visualization of a vascular system after intravenous injection of a fluorescein solution. The images may be photographed or televised. It is used especially in studying the retinal and uveal vasculature.
http://purl.obolibrary.org/obo/SCDO_0001328	Focal Dystonia	http://purl.obolibrary.org/obo/HP_0012638	Abnormal Nervous System Physiology		A rare neurologic movement disorder characterized by sustained muscle contractions of a single body region, usually producing twisting and repetitive movements or abnormal postures or positions.
http://purl.obolibrary.org/obo/SCDO_0001329	Folic Acid	http://purl.obolibrary.org/obo/CHEBI_23888	Drug		A member of the vitamin B family that stimulates the hematopoietic system. It is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses (poaceae). Folic acid is used in the treatment and prevention of folate deficiencies and megaloblastic anemia.
http://purl.obolibrary.org/obo/SCDO_0001330	Follow-Up Studies	http://purl.obolibrary.org/obo/SCDO_0000263	Cohort Studies		Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
http://purl.obolibrary.org/obo/SCDO_0001334	Chronic Phenotype	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		An observable characteristic of disease that is persistent and long standing.
http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		Terms deprecated in the "Phenotype" class.
http://purl.obolibrary.org/obo/SCDO_0001339	Functionality After Stroke Measure	http://purl.obolibrary.org/obo/SCDO_1000297	Quality of Life and Care Diagnostic Instrument		A questionnaire to measure the health status of individuals who had a stroke.
http://purl.obolibrary.org/obo/SCDO_0001340	deprecated Gastrointestinal System	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		'The system concerned with the function and disorders of the gastrointestinal tract, including stomach, intestines, and associated organs including liver, pancreas and gall bladder. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0001342	Gene-Environment Interaction	http://purl.obolibrary.org/obo/SCDO_0000391	Disease Modifier		Combined effects of genotypes and environmental factors together to affect phenotypic characteristics.
http://purl.obolibrary.org/obo/SCDO_0001369	Genetic Variation	http://purl.obolibrary.org/obo/SCDO_0000765	Genetic Phenomena		Deviation(s) in the nucleotide sequence of the genetic material of an individual from that typical of the group to which the individual belongs, or deviation(s) in the nucleotide sequence of the genetic material of offspring from that of its parents.
http://purl.obolibrary.org/obo/SCDO_0001373	deprecated beta C mutation	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		'To be defined by an expert [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0001376	deprecated beta E mutation	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		'To be defined by an expert [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0001377	deprecated beta S mutation	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		'To be defined by an expert [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0001378	HBA1	http://purl.obolibrary.org/obo/SCDO_1000361	Alpha-Globin Gene		This gene provides instructions for making a protein called alpha-globin, which is involved in oxygen transport. This protein is also produced from a nearly identical gene called HBA2.
http://purl.obolibrary.org/obo/SCDO_0001379	HBA2	http://purl.obolibrary.org/obo/SCDO_1000361	Alpha-Globin Gene		This gene provides instructions for making a protein called alpha-globin, which is involved in oxygen transport. This protein is also produced from a nearly identical gene called HBA1.
http://purl.obolibrary.org/obo/SCDO_0001382	Hemoglobin Subunit Gamma	http://purl.obolibrary.org/obo/SCDO_1000012	Beta-Globin Family Members		Gamma Globin is a type of polypeptide chain that when in combination with alpha globin chains forms fetal hemoglobin. Beta-Hemoglobin subunits gamma-1 (147 aa, ~16 kDa) and gamma-2 (147 aa, ~16 kDa) are encoded by the human HBG1 and HBG2 gene respectively, in the beta-globin gene cluster. These proteins play a role in the transport of oxygen to tissues of the fetal body.
http://purl.obolibrary.org/obo/SCDO_0001385	Absence of Alpha Globin Synthesis with Gamma Globin Synthesis	http://purl.obolibrary.org/obo/SCDO_0001384	Reduced Alpha/Gamma Synthesis Ratio		The state, in utero or shortly after birth, in which all four alpha globin genes are deleted or inactivated resulting in absent alpha globin synthesis. If gamma globin synthesis persists, then the resulting phenotype is hemoglobin Barts (four gamma chains) and hemoglobin Bart hydrops fetalis.
http://purl.obolibrary.org/obo/SCDO_0001386	Alpha-Globin Locus Deletion	http://purl.obolibrary.org/obo/NCIT_C19296	Deletion Mutation		A deletion in or of the HBA1 or HBA2 gene that can result in some form of alpha thalassemia.
http://purl.obolibrary.org/obo/SCDO_0001387	Homozygous Deletion of HBA1 and HBA2	http://purl.obolibrary.org/obo/SCDO_0001386	Alpha-Globin Locus Deletion		Deletion of all four alpha-globin genes resulting in the most severe form of alpha thalassemia, Hemoglobin Barts Hydrops Fetalis.
http://purl.obolibrary.org/obo/SCDO_0001388	Insertion	http://purl.obolibrary.org/obo/IDOMAL_50000026	Mutation		Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt genetic translation of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.
http://purl.obolibrary.org/obo/SCDO_0001436	Oxygen Therapy	http://purl.obolibrary.org/obo/SCDO_0001133	Symptomatic Therapeutics		The administration of oxygen to an individual. It is of paramount importance in the peri-operative care of SCD patients as hypoxaemia predisposes to sickling.
http://purl.obolibrary.org/obo/SCDO_0001511	Renal Medullary Carcinoma	http://purl.obolibrary.org/obo/SCDO_0001054	Sickle Cell Related Cancer		Renal medullary carcinoma is a rare, aggressive subtype of renal cell carcinoma characterized by a large, white or tan, firm, infiltrative tumor with microabscess-like foci centered in the renal medulla, typically presenting with hematuria, abdominal/flank pain, weight loss and fever. It is associated with sickle cell trait and disease and metastasis to the bones and lungs is common at time of diagnosis.
http://purl.obolibrary.org/obo/SCDO_0001551	Ethnolinguistics	http://purl.obolibrary.org/obo/NCIT_C16495	Demographic Factor		A part of anthropological linguistics concerned with the interrelation between a language and the cultural behavior of those who speak it.
http://purl.obolibrary.org/obo/SCDO_0001604	Steady State	http://purl.obolibrary.org/obo/SCDO_0000895	Phenotype of Sickle Cell Disease		That period when the patient with sickle cell anaemia is free of infection, pain, or other disease processes.
http://purl.obolibrary.org/obo/SCDO_0001611	deprecated-Renal Insufficiency	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		A reduction in the level of performance of the kidneys in areas of function comprising the concentration of urine, removal of wastes, the maintenance of electrolyte balance, homeostasis of blood pressure, and calcium metabolism.
http://purl.obolibrary.org/obo/SCDO_0001624	Non-Anemic	http://purl.obolibrary.org/obo/NCIT_C3833	Asymptomatic		Not anemic, i.e. no reduction in erythrocytes volume and/or hemoglobin concentration.
http://purl.obolibrary.org/obo/SCDO_0001626	Nonsense Codon	http://purl.obolibrary.org/obo/SCDO_0004623	Codon		An amino acid-specifying codon that has been converted to a stop codon by mutation. Its occurance is abnormal causing premature termination of protein translation and results in production of truncated and non-functional proteins. A nonsense mutation is one that converts an amino acid-specific codon to a stop codon.
http://purl.obolibrary.org/obo/SCDO_0001715	deprecated-Neuropathic Pain	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		Chronic pain caused by damage to nerve fibers. It is usually associated with tissue injury. This pain is usually described as burning, numb, tingling, lancinating, shooting, or paroxysmal in nature and is associated with a sensation of pins and needles. Its severity is also enhanced by exposure to either cold or heat.
http://purl.obolibrary.org/obo/SCDO_0001751	Homozygous Deletion of HBA2	http://purl.obolibrary.org/obo/SCDO_0001386	Alpha-Globin Locus Deletion		Deletion of both HBA2 genes, which results in an alpha-thal-2 (alpha-/alpha-) form of alpha thalassemia trait. With this deletion there is nearly normal production of red blood cells, but there may be a mild anemia.
http://purl.obolibrary.org/obo/SCDO_0001851	Tachycardia	http://purl.obolibrary.org/obo/HP_0011025	Abnormal Cardiovascular System Physiology		A rapid heartrate that exceeds the range of the normal resting heartrate for age, gender or patient population.
http://purl.obolibrary.org/obo/SCDO_0001997	Crystallisation of Hemoglobin	http://purl.obolibrary.org/obo/SCDO_1000253	Abnormal Biological Process		The process whereby a mutation in a hemoglobin molecule causes conformational changes in the hemoglobin molecule, which cause increased hydrophobicity of the molecule, which result in the formation of crystals consisting of the mutated hemoglobin molecules. This type of crystallisation is observed in hemoglobins with the HbC mutation.
http://purl.obolibrary.org/obo/SCDO_0002039	Zinc Deficiency	http://purl.obolibrary.org/obo/SCDO_1000261	Avitaminosis		A deficiency of the essential metal Zinc; an essential cofactor for many enzymes. Zinc deficiency is caused by a lack of zinc in the diet, loss of zinc after absorption, for example through loss through burns, inability to absorb Zinc, or increased loss through exercise.
http://purl.obolibrary.org/obo/SCDO_0002107	deprecated-Nature of Mutations	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		This represents the phenotypic feature of mutational effects on a given property of an organism biological system [Gaston K. Mazandu, []].
http://purl.obolibrary.org/obo/SCDO_0002125	Confidentiality	http://purl.obolibrary.org/obo/SCDO_0300005	Research Characteristics		The privacy of information and its protection against unauthorized disclosure.
http://purl.obolibrary.org/obo/SCDO_0002130	Transcriptome	http://purl.obolibrary.org/obo/SCDO_0005722	Genetic Structure		The pattern of gene expression at the level of genetic transcription in a specific organism or under specific circumstances in specific cells.
http://purl.obolibrary.org/obo/SCDO_0002240	Disease Severity	http://purl.obolibrary.org/obo/NCIT_C43646	Association		The presence and extensiveness of a disease in the body. It is objectively evaluated through diagnostic testing and physiological examination of the impaired biological organs or tissues, in cases in which disease severity can be distinguished from other realms of health, as in heart disease.
http://purl.obolibrary.org/obo/SCDO_0002243	Research Participant Compensation	http://purl.obolibrary.org/obo/NCIT_C19332	Personal Attribute		Reimbursement of research participants for costs directly incurred during the research, such as travel costs and reasonable compensation for their inconvenience and time spent. Compensation can be monetary or non-monetary.
http://purl.obolibrary.org/obo/SCDO_0002305	Hemoglobin D Disease Causal Mutation	http://purl.obolibrary.org/obo/IDOMAL_50000026	Mutation		A mutation wholly or partly responsible for causing Hemoglobin D Disease.
http://purl.obolibrary.org/obo/SCDO_0002337	Ethical Conduct	http://purl.obolibrary.org/obo/SCDO_1000430	Ethics Related Concept		The abiding by applicable principles such as 1. compliance by research institutions; 2. obtaining and documenting informed consent; 3. Research Ethics Committee membership function, operations, review of research, and record keeping; 4. additional protection for certain vulnerable research subjects - pregnant women, prisoners, and children
http://purl.obolibrary.org/obo/SCDO_0002475	Beta-Zero Thalassemia Mutation	http://purl.obolibrary.org/obo/SCDO_0009731	Beta Thalassemia Mutation		A mutation in the beta-globin gene, HBB, that results in absent beta globin synthesis.
http://purl.obolibrary.org/obo/SCDO_0002674	Abnormality of Metabolism/Homeostasis	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		An abnormality of the body's metabolism or homeostasis.
http://purl.obolibrary.org/obo/SCDO_0002798	Pharmacogenomic Variants	http://purl.obolibrary.org/obo/NCIT_C17004	Genetic Polymorphism		Naturally occurring genetic variations associated with drug response. While these variants are not markers for genetic predisposition to disease, they influence pharmacokinetics and pharmacodynamics and often occur on genes encoding drug metabolism enzymes and transporters (e.g., angiotensin converting enzyme; cytochrome P-450 CYP2D6).
http://purl.obolibrary.org/obo/SCDO_0002814	deprecated Globin Gene	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		'The hemoglobin molecule that transports oxygen in the blood is made up of a number of components. Human hemoglobin is a tetramer: in adults it is made up of two alpha globins and two beta globins; in the fetus, of two alpha and two g globins; and in the embryo, two e and two z globins. The sequences of these five globin types are similar and the genes that code for them occur in clusters on the chromosomes. In humans, there are two main clusters of globin genes: the alpha globin cluster on chromosome 16 and the beta globin cluster on chromosome 11. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0002829	Sample	http://purl.obolibrary.org/obo/NCIT_C19332	Personal Attribute		A sample is a limited quantity of something (e.g. an individual or set of individuals from a population, or a portion of a material) to be used for testing, analysis, inspection, investigation, demonstration, or trial use.
http://purl.obolibrary.org/obo/SCDO_0002939	Polymerised Hemoglobin	http://purl.obolibrary.org/obo/SCDO_0003807	Abnormal Hemoglobin		Deoxygenated malfunctioning or mutated hemoglobins which clump together and form a long polymer in a process called polymerisation.
http://purl.obolibrary.org/obo/SCDO_0003028	Ethnic Status	http://purl.obolibrary.org/obo/SCDO_0001551	Ethnolinguistics		A person's ethnic status, whether conserved or mixed ethnicity.
http://purl.obolibrary.org/obo/SCDO_0003065	obsolete Non-SCD Structural Variants	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		Genetic variation in the structure leading to the abnomality of protein structure in non-sickle cell disease hemoglobin.
http://purl.obolibrary.org/obo/SCDO_0003572	Consent Form	http://purl.obolibrary.org/obo/SCDO_0007597	Descriptor of Consent		Documents describing a medical treatment or research project, including proposed procedures, risks, and alternatives, that are to be signed by an individual, or the individual's proxy, to indicate his/her understanding of the document and a willingness to undergo the treatment or to participate in the research.
http://purl.obolibrary.org/obo/SCDO_0003675	Single Nucleotide Polymorphism	http://purl.obolibrary.org/obo/NCIT_C17004	Genetic Polymorphism		A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
http://purl.obolibrary.org/obo/SCDO_0003696	Peripheral Blood Film	http://purl.obolibrary.org/obo/NCIT_C79903	Blood Smear		A procedure in which a sample of peripheral blood is viewed under a microscope to count different circulating blood cells (red blood cells, white blood cells, platelets, etc.) and see whether the cells look normal.
http://purl.obolibrary.org/obo/SCDO_0003712	Proxy Consent	http://purl.obolibrary.org/obo/NCIT_C25460	Consent		A legal representation or family member of the participant gives consent on behalf of the patient.
http://purl.obolibrary.org/obo/SCDO_0003736	Dynamic Consent	http://purl.obolibrary.org/obo/SCDO_0007087	Informed Consent		Dynamic consent is a personalised, communication interface to enable greater participant engagement in clinical and research activities.The interface facilitates two-way communication to stimulate a more engaged, informed and scientifically literate participant population where individuals can tailor and manage their own consent preferences. It has the potential to be applied more broadly to situations where there are multiple and varied uses of data requiring different kinds of consent over a period of time.
http://purl.obolibrary.org/obo/SCDO_0003742	Splenectomy	http://purl.obolibrary.org/obo/SCDO_0001133	Symptomatic Therapeutics		Surgical procedure involving either partial or entire removal of the spleen.
http://purl.obolibrary.org/obo/SCDO_0003807	Abnormal Hemoglobin	http://purl.obolibrary.org/obo/SCDO_0006921	Hemoglobin Variant		Hemoglobin characterized by structural alterations within the molecule that confer an inherited health condition phenotype. The alteration can be either absence, addition or substitution of one or more amino acids in the globin part of the molecule at selected positions in the polypeptide chains.
http://purl.obolibrary.org/obo/SCDO_0003894	Gap PCR	http://purl.obolibrary.org/obo/SCDO_0000913	Polymerase Chain Reaction		The polymerase chain reaction (PCR) is the most common method to detect the deletional thalassaemias. Gap-PCR amplifies the deleted DNA sequence using the primers flanking the deleted region 10. Three primers are designed for each deletion to amplify the normal (undeleted) and deleted gene sequences.
http://purl.obolibrary.org/obo/SCDO_0004061	Genotype	http://purl.obolibrary.org/obo/SCDO_0000765	Genetic Phenomena		The genetic constitution of the individual, comprising the alleles present at each genetic locus.
http://purl.obolibrary.org/obo/SCDO_0004078	Girdle Syndrome	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		Characterized by an established ileus, with vomiting, a silent distended abdomen and distended bowel loops and fluid levels on abdominal x-ray. Some hepatic enlargement is common, and it is often associated with bilateral basal lung consolidation (chest syndrome).
http://purl.obolibrary.org/obo/SCDO_0004139	Adult Hemoglobin	http://purl.obolibrary.org/obo/SCDO_0006835	Normal Hemoglobin		The most common and normal adult human hemoglobin tetramer, comprising over 97% of the total red blood cell hemoglobin and consisting of two alpha chains and two beta chains.
http://purl.obolibrary.org/obo/SCDO_0004187	Hemolytic Crisis	http://purl.obolibrary.org/obo/HP_0001871	Abnormality of Blood and Blood-Forming Tissues		May be caused by an acute VOC, malarial infection or oxidant drug exposure in individuals with concomitant glucose-6-phosphate dehydrogenase (G6PD) deficiency. Haemolytic crisis may be distinguished from aplastic crisis by the finding of a reticulocytosis as opposed to a reticulocytopenia.
http://purl.obolibrary.org/obo/SCDO_0004277	Assent	http://purl.obolibrary.org/obo/SCDO_0007597	Descriptor of Consent		A term used to express willingness to participate in research by persons who are by definition too young to give informed consent but who are old enough to understand the proposed research in general, its expected risks and possible benefits, and the activities expected of them as subjects.
http://purl.obolibrary.org/obo/SCDO_0004444	Delta Beta Globin Fusion Chain	http://purl.obolibrary.org/obo/SCDO_1000012	Beta-Globin Family Members		The protein product of the fusion of the gene products of the HBD and HBB genes that causes the mutation which causes the Hemoglobin Lepore Trait.
http://purl.obolibrary.org/obo/SCDO_0004576	Chronic Hypersplenism	http://purl.obolibrary.org/obo/SCDO_0006905	Hypersplenism		Chronic splenic sequestration associated with enlarged spleen and cytopaenia with anaemia and reduction in white blood cells and platelets. The anaemia is usually chronic in nature and patients rarely present with signs of heart failure.
http://purl.obolibrary.org/obo/SCDO_0004598	Anticodon	http://purl.obolibrary.org/obo/SCDO_0005593	Genetic Code		The sequential set of three nucleotides in transfer RNA that interacts with its complement in messenger RNA, the Codon, during translation in the ribosome.
http://purl.obolibrary.org/obo/SCDO_0004623	Codon	http://purl.obolibrary.org/obo/SCDO_0005593	Genetic Code		Also known as sense codon, a set of three nucleotides in a protein coding sequence that specifies individual amino acids or a termination signal (terminator codon). Most codons are universal, but some organisms do not produce the transfer RNAs complementary to all codons. These codons are referred to as unassigned codons (nonsense codons).
http://purl.obolibrary.org/obo/SCDO_0004716	Initiator Codon	http://purl.obolibrary.org/obo/SCDO_0004623	Codon		A codon that directs initiation of protein translation (Translation, Genetic) by stimulating the binding of initiator tRNA (RNA, TRANSFER, MET). In prokaryotes, the codons AUG or GUG can act as initiators while in eukaryotes, AUG is the only initiator codon.
http://purl.obolibrary.org/obo/SCDO_0004829	Transient Ischemic Attack	http://purl.obolibrary.org/obo/HP_0030680	Abnormal Cardiovascular System Morphology		Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic).
http://purl.obolibrary.org/obo/SCDO_0004836	Angina	http://purl.obolibrary.org/obo/HP_0011025	Abnormal Cardiovascular System Physiology		A chest pain that is caused when your heart muscle doesn't get enough oxygen-rich blood.
http://purl.obolibrary.org/obo/SCDO_0004847	Acute Hepatic Sequestration	http://purl.obolibrary.org/obo/HP_0001392	Abnormality of the Liver		A rarely recognized complication of vaso-occlusive crisis. It is characterized by a presentation of right upper quadrant pain in the liver. A smooth, tender, enlarged liver is noted on physical exam. The lab values show a decrease in the hemoglobin/hematocrit. An increase in reticulocyte count is also seen.
http://purl.obolibrary.org/obo/SCDO_0004860	deprecated-Amoxicillin	http://purl.obolibrary.org/obo/SCDO_1000035	from therapeutics		'A penicillin in which the substituent at position 6 of the penam ring is a 2-amino-2-(4-hydroxyphenyl)acetamido group. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0004888	Functional Hyposplenism	http://purl.obolibrary.org/obo/HP_0001743	Abnormality of the Spleen		An acquired disorder caused by several hematological and immunological diseases and characterized by impairment of splenic function.
http://purl.obolibrary.org/obo/SCDO_0004905	Beta-Globin Locus Deletion	http://purl.obolibrary.org/obo/NCIT_C19296	Deletion Mutation		Deletion of a part of the beta-globin locus.
http://purl.obolibrary.org/obo/SCDO_0005167	Chronic Anemia	http://purl.obolibrary.org/obo/HP_0001903	Anemia		Long lasting form of anemia.
http://purl.obolibrary.org/obo/SCDO_0005191	Hyperhemolysis	http://purl.obolibrary.org/obo/SCDO_0000895	Phenotype of Sickle Cell Disease		An increase in the rate of hemolysis, in conjunction with specific clinical complications of sickle cell disease.
http://purl.obolibrary.org/obo/SCDO_0005243	Comparative Genomic Hybridisation	http://purl.obolibrary.org/obo/SCDO_0000448	Genetic Technique		A method for comparing two sets of chromosomal DNA by analyzing differences in the copy number and location of specific sequences. It is used to look for large sequence changes such as deletions, duplications, amplifications, or translocations.
http://purl.obolibrary.org/obo/SCDO_0005279	deprecated High Reticulocyte Count	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		An abnormally high number of reticulocytes per unit volume of blood. The normal fraction of reticulocytes in the blood depends on the clinical situation but is usually 0.5% to 2.5% in adults and 2% to 6% in infants.
http://purl.obolibrary.org/obo/SCDO_0005339	Globin Phenotype	http://purl.obolibrary.org/obo/SCDO_0009613	Protein Phenotype		The physical characteristics of the globin polypeptides that form hemoglobins.
http://purl.obolibrary.org/obo/SCDO_0005379	Database	http://purl.obolibrary.org/obo/SCDO_0300003	Publication Formats		Work consisting of a structured file of information or a set of logically related data stored and retrieved using computer-based means.
http://purl.obolibrary.org/obo/SCDO_0005446	Fetal Hemoglobin	http://purl.obolibrary.org/obo/SCDO_0006835	Normal Hemoglobin		The major component of hemoglobin in the fetus. This hemoglobin has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by leukemia and several types of anemia.
http://purl.obolibrary.org/obo/SCDO_0005464	Myocardial Ischemia	http://purl.obolibrary.org/obo/SCDO_0000665	Ischemia		A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (coronary artery disease), to obstruction by a thrombus (coronary thrombosis), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (myocardial infarction).
http://purl.obolibrary.org/obo/SCDO_0005580	deprecated-Avascular Necrosis of the Femoral Head	http://purl.obolibrary.org/obo/NCIT_C118385	deprecated-Avascular Necrosis		Avascular necrosis of femoral head (ANFH) is a severely disabling disease characterised by progressive groin pain, a limping gait, leg length discrepancy, collapse of the subchondral bone, limitation of hip function and eventual degeneration of the hip joint requiring total hip arthroplasty.
http://purl.obolibrary.org/obo/SCDO_0005593	Genetic Code	http://purl.obolibrary.org/obo/SCDO_0005722	Genetic Structure		The meaning ascribed to the base sequence with respect to how it is translated into amino acid sequence. The start, stop, and order of amino acids of a protein is specified by consecutive triplets of nucleotides called codons.
http://purl.obolibrary.org/obo/SCDO_0005671	HBB and HBD Deletion	http://purl.obolibrary.org/obo/SCDO_1000366	Delta Beta Thalassemia Mutation		Deletion of the HBB and HBD genes that results in delta-beta thalassemia.
http://purl.obolibrary.org/obo/SCDO_0005722	Genetic Structure	http://purl.obolibrary.org/obo/SCDO_0000765	Genetic Phenomena		A biological object that contains genetic information and that is involved in transmitting genetically encoded traits from one organism to another.
http://purl.obolibrary.org/obo/SCDO_0005927	Justice	http://purl.obolibrary.org/obo/GSSO_003239	Ethical Principle		An ethical principle that obligates one to treat people fairly. Distributive justice refers to allocating benefits and harms fairly; procedural justice refers to using fair processes to make decisions that affect people; formal justice refers to treating similar cases in the same way. In human subjects research, the principle of justice implies that subjects should be selected equitably.
http://purl.obolibrary.org/obo/SCDO_0006000	Fever	http://purl.obolibrary.org/obo/SCDO_0002674	Abnormality of Metabolism/Homeostasis		Elevated body temperature due to failed thermoregulation, or inflammation or immune responses.
http://purl.obolibrary.org/obo/SCDO_0006036	Minor	http://purl.obolibrary.org/obo/SCDO_0002125	Confidentiality		A person who has not attained the age at which full civil rights are accorded.
http://purl.obolibrary.org/obo/SCDO_0006070	Mixed Ethnicity	http://purl.obolibrary.org/obo/SCDO_0003028	Ethnic Status		An ethnic group that includes persons with significant ethnic contributions from more than one group.
http://purl.obolibrary.org/obo/SCDO_0006339	Research	http://purl.obolibrary.org/obo/SCDO_0001000	SCDO		Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws.
http://purl.obolibrary.org/obo/SCDO_0006429	Gallbladder Empyema	http://purl.obolibrary.org/obo/HP_0025031	Abnormality of the Digestive System		An uncommon complication of cholecystitis and refers to a situation where the gallbladder lumen is filled and distended by purulent material (pus).
http://purl.obolibrary.org/obo/SCDO_0006517	Human Subject Research	http://purl.obolibrary.org/obo/SCDO_0300005	Research Characteristics		Research involving the collection, storage, or use of private data or biological samples from living individuals by means of interactions, interventions, surveys, or other research methods or procedures.
http://purl.obolibrary.org/obo/SCDO_0006589	Cordocentesis	http://purl.obolibrary.org/obo/SCDO_0000505	Hematology Screening Test		The collecting of fetal blood samples typically via endoscopic ultrasound guided fine needle aspiration from the umbilical vein, followed by examination of the blood to detect fetal abnormalities.
http://purl.obolibrary.org/obo/SCDO_0006613	Material Transfer Agreement	http://purl.obolibrary.org/obo/SCDO_0300006	Information Disclosure		A material transfer agreement (MTA) is a type of legally enforceable contract employed by research institutions and companies to set the terms under which their materials and associated data may be obtained and used by others.
http://purl.obolibrary.org/obo/SCDO_0006706	Bioethics	http://purl.obolibrary.org/obo/NCIT_C39796	Ethics		A branch of applied ethics that studies the value implications of practices and developments in life sciences, medicine, and health care.
http://purl.obolibrary.org/obo/SCDO_0006832	Ascorbic Acid Deficiency	http://purl.obolibrary.org/obo/SCDO_1000261	Avitaminosis		A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into SCURVY in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)
http://purl.obolibrary.org/obo/SCDO_0006833	Moyamoya Disease	http://purl.obolibrary.org/obo/SCDO_0000267	Comorbid Disease		A rare intracranial arteriopathy involving progressive stenosis of the cerebral vasculature located at the base of the brain causing transient ischemic attacks or strokes.
http://purl.obolibrary.org/obo/SCDO_0006835	Normal Hemoglobin	http://purl.obolibrary.org/obo/NCIT_C16676	Hemoglobin		Hemoglobin that presents no inherited health condition phenotype.
http://purl.obolibrary.org/obo/SCDO_0006847	Aplastic Crisis	http://purl.obolibrary.org/obo/SCDO_1000000	Acute Phenotype		An acute form of acquired red cell aplasia. A significant change in blood picture is observed, characterised by a precipitous fall in the haemoglobin level (>20 g/l beyond steady state level) and reduced (<1%) or absent reticulocytes in the peripheral blood. The total white blood cell or platelet counts may or may not be affected. In addition, there is no significant increase in the unconjugated fraction of serum bilirubin.The most common cause is infection by parvovirus B19, a DNA virus that replicates inside immature red blood cells in the bone marrow, resulting in severe anaemia (hemoglobin levels well below steady state) and low reticulocyte count. It is rarely recurrent.
http://purl.obolibrary.org/obo/SCDO_0006860	HBG1 and/or HBG2 Mutations	http://purl.obolibrary.org/obo/IDOMAL_50000026	Mutation		Mutations in the HBG1 and/or HBG2 genes. Such mutations can lead to variably increased levels of fetal hemoglobin (Hb) (Hb F, alpha2gamma2) in the syndrome of hereditary persistence of fetal Hb (HPFH).
http://purl.obolibrary.org/obo/SCDO_0006905	Hypersplenism	http://purl.obolibrary.org/obo/HP_0001743	Abnormality of the Spleen		Condition characterized by splenomegaly, some reduction in the number of circulating blood cells in the presence of a normal or hyperactive bone marrow, and the potential for reversal by splenectomy.
http://purl.obolibrary.org/obo/SCDO_0006909	Hyper-Hemolytic Crisis	http://purl.obolibrary.org/obo/SCDO_0004187	Hemolytic Crisis		Significant change in blood picture characterised by a precipitous fall in the haemoglobin level associated with jaundice, marked reticulocytosis, and polychromasia on the blood smear, increased unconju- gated hyperbilirubinaemia, and increased urobilinogen content in urine above the steady state level for each individual patient.
http://purl.obolibrary.org/obo/SCDO_0006911	Conserved Ethnicity	http://purl.obolibrary.org/obo/SCDO_0003028	Ethnic Status		An ethnic group that includes persons with ethnic contributions from only one ethnic group.
http://purl.obolibrary.org/obo/SCDO_0006921	Hemoglobin Variant	http://purl.obolibrary.org/obo/NCIT_C16676	Hemoglobin		Hemoglobin with altered structural and biochemical properties.
http://purl.obolibrary.org/obo/SCDO_0007087	Informed Consent	http://purl.obolibrary.org/obo/NCIT_C25460	Consent		Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment.
http://purl.obolibrary.org/obo/SCDO_0007161	Acute Splenic Sequestration Crisis	http://purl.obolibrary.org/obo/SCDO_1000000	Acute Phenotype		Significant change in blood picture characterised by a precipitous fall in the haemoglobin level of at least 20 g/l and accompanied by a rapidly enlarging spleen or liver (greater than 2 cm from the steady state level) and reticulocytosis above the steady state level for each individual patient. Signs of acute circulatory insufficiency such tachypnoea, tachycardia, and hypotension may or may not be present. It is the earliest life-threatening complication seen in patients with SCD besides pneumococcal infections.
http://purl.obolibrary.org/obo/SCDO_0007192	Quantitative Hemoglobinopathy	http://purl.obolibrary.org/obo/SCDO_0000552	Hemoglobinopathy		A hemoglobinopathy caused by a reduced or imbalanced synthesis of a normal globin chain or by a defect in the switch between synthesis of different types of normal hemoglobin.
http://purl.obolibrary.org/obo/SCDO_0007212	obsolete Other Molecules	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		'Other molecules are complexes which do not contain protein or RNA, including lipids, carbohydrates, etc.'
http://purl.obolibrary.org/obo/SCDO_0007281	Adrenal Insufficiency	http://purl.obolibrary.org/obo/HP_0000834	Abnormality of the Adrenal Glands		Insufficient production of steroid hormones (primarily cortisol) by the adrenal glands as a result of a primary defect in the glands themselves.
http://purl.obolibrary.org/obo/SCDO_0007495	Risk	http://purl.obolibrary.org/obo/SCDO_0006339	Research		The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
http://purl.obolibrary.org/obo/SCDO_0007519	Community Engagement	http://purl.obolibrary.org/obo/SCDO_0300005	Research Characteristics		A process of inclusive participation that supports mutual respect of values, strategies, and actions for authentic partnership of people affiliated by geographic location, shared interest, or similar circumstances to address issues affecting community wellbeing.
http://purl.obolibrary.org/obo/SCDO_0007565	deprecated Major Area	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		Distinct geographical area.
http://purl.obolibrary.org/obo/SCDO_0007618	deprecated-Avascular necrosis of the humeral head	http://purl.obolibrary.org/obo/NCIT_C118385	deprecated-Avascular Necrosis		In situ death of bone within the humeral head due to disruption of blood supply.
http://purl.obolibrary.org/obo/SCDO_0007623	Molecular Phenotype	http://purl.obolibrary.org/obo/OGMS_0000023	Phenotype		The molecular characteristics of a cell of tissue including expressed coding and non-coding RNAs, proteins and their post-translational modifications, lipids, carbohydrates and small molecules that characterize the state in a cell or tissue and that result from the interaction of its genotype and the environment.
http://purl.obolibrary.org/obo/SCDO_0007624	Beta Thalassemia Genotype	http://purl.obolibrary.org/obo/SCDO_0004061	Genotype		HBB genetic variants that result in reduced or absent hemoglobin subunit beta production.
http://purl.obolibrary.org/obo/SCDO_0007656	Sickle Cell Thalassemia	http://purl.obolibrary.org/obo/SCDO_1000215	Structural and Quantitative Hemoglobinopathy		Hemolytic anemia, in which patients are compound or double heterozygous for both the sickle cell gene and a thalassemia gene.
http://purl.obolibrary.org/obo/SCDO_0007897	Ethics Approval	http://purl.obolibrary.org/obo/SCDO_1000430	Ethics Related Concept		A document containing the determination of the Research Ethics Committee (REC) that the clinical study with human subject participation has been reviewed and may be conducted at a particular study site within the constraints set forth by the REC and other institutional and federal requirements. The regulations require that an REC conduct continuing review of research at intervals appropriate to the degree of risk, but not less than once a year.
http://purl.obolibrary.org/obo/SCDO_0007900	Embryonic Hemoglobin	http://purl.obolibrary.org/obo/SCDO_0006835	Normal Hemoglobin		Hemoglobin produced in the blood islands in the embryonic yolk sac during the mesoblastic stage of gestation. There are four different embryonic hemoglobins, Hemoglobin Gower 1, Hemoglobin Gower 2, Hemoglobin Portland 1 and Hemoglobin Portland 2.
http://purl.obolibrary.org/obo/SCDO_0008037	Acute Symptomatic Seizure	http://purl.obolibrary.org/obo/SCDO_1000000	Acute Phenotype		A seizure that occurs in the context of a brain insult (systemic, toxic, or metabolic) and may not recur when the underlying cause has been removed or the acute phase has elapsed. It is often associated with infections, infarctions, and severe metabolic or sickle cell complications.
http://purl.obolibrary.org/obo/SCDO_0008251	Homozygous Deletion of HBA1	http://purl.obolibrary.org/obo/SCDO_0001386	Alpha-Globin Locus Deletion		Deletion of both HBA1 genes, which results in an alpha-thal-2 (alpha-/alpha-) form of alpha thalassemia trait. With this deletion there is nearly normal production of red blood cells, but there may be a mild anemia.
http://purl.obolibrary.org/obo/SCDO_0008262	Structural Hemoglobinopathy	http://purl.obolibrary.org/obo/SCDO_0000552	Hemoglobinopathy		A hemoglobinopathy caused by the presence of structurally abnormal hemoglobins.
http://purl.obolibrary.org/obo/SCDO_0008595	Chronic Arthritis	http://purl.obolibrary.org/obo/HP_0001369	Arthritis		Persistence of an inflammatory event in the articulation overtime.
http://purl.obolibrary.org/obo/SCDO_0008623	Vaso-Occlusion	http://purl.obolibrary.org/obo/HP_0030680	Abnormal Cardiovascular System Morphology		The obstruction of blood vessels by altered erythrocytes that can result in pain, anemia and tissue ischemia.
http://purl.obolibrary.org/obo/SCDO_0008625	Right Upper Quadrant Syndrome	http://purl.obolibrary.org/obo/SCDO_0000895	Phenotype of Sickle Cell Disease		Characterized by pain and discomfort in the right upper quadrant (RUQ) of the abdomen caused by a number of possible aetiologies in sickle cell disease. Causes of RUQ pain may be divided into pain originating from the liver or gall bladder versus other origins of abdominal pain in that region.
http://purl.obolibrary.org/obo/SCDO_0008688	Biobank	http://purl.obolibrary.org/obo/SCDO_0300003	Publication Formats		A biobank is a collections of samples of biological substances (e.g. tissue, blood, DNA) which are linked to data about the samples and their donors. They have a dual nature as collections of samples and data and usually require investigators or institutions to agree to certain conditions as a condition for sharing samples or data with them.
http://purl.obolibrary.org/obo/SCDO_0008713	Sickle Cell Anemia Associated with Alpha Thalassemia	http://purl.obolibrary.org/obo/SCDO_1000106	Sickle Cell Disease		The concurrence of sickle cell anemia and alpha-thalassemia. This condition is thought to result in less severe hemolytic anemia due to reduced concentration of hemoglobin S and its polymerization within red blood cells.
http://purl.obolibrary.org/obo/SCDO_0008778	Dental Radiograph	http://purl.obolibrary.org/obo/SCDO_0000963	Radiography		A radiograph of dental structures made on x-ray film or stored as a digital image. The radiographs may be extraoral or intraoral. Three common types of intraoral dental images are periapical, interproximal, and occlusal radiographs.
http://purl.obolibrary.org/obo/SCDO_0008888	Iron Chelation Therapy	http://purl.obolibrary.org/obo/SCDO_0001133	Symptomatic Therapeutics		The removal of excess iron from the body with special drugs.
http://purl.obolibrary.org/obo/SCDO_0008925	Autonomy	http://purl.obolibrary.org/obo/GSSO_003239	Ethical Principle		The capacity for self-governance, i.e. the ability to make reasonable decisions.
http://purl.obolibrary.org/obo/SCDO_0008937	Central Retinal Artery Occlusion	http://purl.obolibrary.org/obo/HP_0030680	Abnormal Cardiovascular System Morphology		Blockage of blood flow in the central retinal artery. Results in sudden painless loss of vision and occurs in children and young adults. Thrombus formation in the retinal artery occurs spontaneously or in association with hyphema, Moyamoya and acute chest sydrome. There is no associated pain and it may be unilateral or bilateral.
http://purl.obolibrary.org/obo/SCDO_0008990	Vertebral Collapse	http://purl.obolibrary.org/obo/HP_0000924	Abnormality of the Skeletal System		Occurs where there is infarction of vertebral bone marrow, leading to collapse of the vertebrae with a typical 'fish mouth' appearance. It is often asymptomatic, but may cause acute and/or long term pain requiring analgesia and mechanical support such as a brace. Can be an acute or chronic bone problem in SCD.
http://purl.obolibrary.org/obo/SCDO_0009089	Non-Maleficience	http://purl.obolibrary.org/obo/GSSO_003239	Ethical Principle		Principle dictating that harm should not come to individuals as a result of their participation in a research project.
http://purl.obolibrary.org/obo/SCDO_0009117	Folate Deficiency	http://purl.obolibrary.org/obo/SCDO_1000261	Avitaminosis		A nutritional condition produced by a deficiency of folic acid in the diet.
http://purl.obolibrary.org/obo/SCDO_0009169	obsolete Sickle Plus Structural Variant	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		A hemoglobinopathy caused by compound heterozygous inheritance of one hemoglobin S allele and one hemoglobin allele that produces structurally abnormal hemoglobin.
http://purl.obolibrary.org/obo/SCDO_0009279	Unstable Hemoglobin	http://purl.obolibrary.org/obo/SCDO_0003807	Abnormal Hemoglobin		Hemoglobin with decreased solubility in the red cell due to substitutions in the primary sequence of globin which alters the tertiary or quaternary structure of the molecule and results in a globin polypeptide/hemoglobin tetramer that is unstable and precipitates intracellularly, reducing the red blood cell lifespan.
http://purl.obolibrary.org/obo/SCDO_0009350	Splenic Sequestration	http://purl.obolibrary.org/obo/HP_0001743	Abnormality of the Spleen		An acute condition of intrasplenic pooling of large amounts of blood.
http://purl.obolibrary.org/obo/SCDO_0009445	Renal Papillary Necrosis	http://purl.obolibrary.org/obo/HP_0000077	Abnormality of the Kidney		A complication of kidney diseases characterized by cell death involving kidney papilla in the kidney medulla. Damages to this area may hinder the kidney to concentrate urine resulting in polyuria. Sloughed off necrotic tissue may block kidney pelvis or ureter. Necrosis of multiple renal papillae can lead to kidney failure.
http://purl.obolibrary.org/obo/SCDO_0009488	obsolete Molecule	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		'Any single chemical entity that is an electrically neutral entity consisting of more than one atom. Each atom carries a certain number of electrons that orbit around the nucleus.[Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0009532	Beneficence	http://purl.obolibrary.org/obo/GSSO_003239	Ethical Principle		Effort made to secure the well-being of persons, maximizing possible benefits and minimizing possible harms.
http://purl.obolibrary.org/obo/SCDO_0009613	Protein Phenotype	http://purl.obolibrary.org/obo/SCDO_0009884	Biochemical Phenotype		The physical characteristics and levels of proteins that characterize the state in a cell or tissue and that result from the interaction of its genotype and the environment.
http://purl.obolibrary.org/obo/SCDO_0009620	deprecated Low Reticulocyte Count	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		An abnormally low number of reticulocytes per unit volume of blood.
http://purl.obolibrary.org/obo/SCDO_0009635	deprecated Aplastic Crises	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		'The aplastic crisis is temporary cessation of red cell production. This usually affect sickle cell patients, because of the markedly shortened red cell survival time in patients with sickle cell disease, a precipitous drop in hemoglobin occurs in the absence of adequate reticulocytosis. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0009731	Beta Thalassemia Mutation	http://purl.obolibrary.org/obo/IDOMAL_50000026	Mutation		A mutation in the beta-globin gene, HBB, that causes decreased or absent beta-globin synthesis.
http://purl.obolibrary.org/obo/SCDO_0009786	Other HBB Variants	http://purl.obolibrary.org/obo/SCDO_1000038	SCD Causal Mutation		A genetic mutation in the HBB gene that results in absent or decreased hemoglobin subunit beta or an abnormal hemoglobin other than Hb S.
http://purl.obolibrary.org/obo/SCDO_0009884	Biochemical Phenotype	http://purl.obolibrary.org/obo/SCDO_0007623	Molecular Phenotype		The proteins and their post-translational modifications, lipids, carbohydrates and small molecules that characterize the state in a cell or tissue and that result from the interaction of its genotype and the environment.
http://purl.obolibrary.org/obo/SCDO_0010000	obsolete Other Genotypes	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		'Genotypes which are not specific to sickle cell trait.'
http://purl.obolibrary.org/obo/SCDO_0300002	Research Ethics	http://purl.obolibrary.org/obo/NCIT_C39796	Ethics		The moral obligations governing the conduct of research. Used for discussions of research ethics as a general topic.
http://purl.obolibrary.org/obo/SCDO_0300003	Publication Formats	http://purl.obolibrary.org/obo/SCDO_0006339	Research		Specific genre of publication.
http://purl.obolibrary.org/obo/SCDO_0300004	Epidemiologic Study Characteristics	http://purl.obolibrary.org/obo/SCDO_0000437	Epidemiologic Studies		Types and formulations of studies used in epidemiological and clinical research.
http://purl.obolibrary.org/obo/SCDO_0300005	Research Characteristics	http://purl.obolibrary.org/obo/SCDO_0006339	Research		Elements, types, descriptions and formulations of a research study.
http://purl.obolibrary.org/obo/SCDO_0300006	Information Disclosure	http://purl.obolibrary.org/obo/SCDO_0002125	Confidentiality		Revealing of information, by oral or written communication.
http://purl.obolibrary.org/obo/SCDO_0300007	Parental Notification	http://purl.obolibrary.org/obo/SCDO_0300006	Information Disclosure		Reporting to parents or guardians about care to be provided to a minor (minors).
http://purl.obolibrary.org/obo/SCDO_0300008	Mandatory Reporting	http://purl.obolibrary.org/obo/SCDO_0300006	Information Disclosure		A legal requirement that designated types of information acquired by professionals or institutions in the course of their work be reported to appropriate authorities.
http://purl.obolibrary.org/obo/SCDO_0300009	Data Anonymization	http://purl.obolibrary.org/obo/SCDO_0002125	Confidentiality		Making information permanently non-identifiable that is associated with the identity of specific entities via encryption or other methods.
http://purl.obolibrary.org/obo/SCDO_1000000	Acute Phenotype	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		An observable characteristic of disease that has a severe and rapid onset of symptoms with short duration.
http://purl.obolibrary.org/obo/SCDO_1000001	deprecated Research Subject ID	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		A unique identifier generated either manually or electronically when adding a subject to a study.
http://purl.obolibrary.org/obo/SCDO_1000004	Renal Replacement Therapy	http://purl.obolibrary.org/obo/SCDO_0001129	Supportive Therapeutics		Procedures which temporarily or permanently remedy insufficient cleansing of body fluids by the kidneys.
http://purl.obolibrary.org/obo/SCDO_1000007	Hemoglobin D	http://purl.obolibrary.org/obo/SCDO_0003807	Abnormal Hemoglobin		An abnormal hemoglobin caused by various point mutations within the HBB gene. This form of hemoglobin prevents red blood cells from carrying oxygen effectively. There are at least 8 different types of hemoglobin D.
http://purl.obolibrary.org/obo/SCDO_1000008	Hemoglobin M	http://purl.obolibrary.org/obo/SCDO_0003807	Abnormal Hemoglobin		A group of abnormal hemoglobins in which amino acid substitutions take place in either the alpha, beta or gamma chains but near the heme iron. This results in facilitated oxidation of the hemoglobin to yield excess methemoglobin which leads to cyanosis.
http://purl.obolibrary.org/obo/SCDO_1000009	Hemoglobin E	http://purl.obolibrary.org/obo/SCDO_0003807	Abnormal Hemoglobin		An abnormal hemoglobin that results from the substitution of lysine for glutamic acid at position 26 of the beta chain. It is most frequently observed in southeast Asian populations.
http://purl.obolibrary.org/obo/SCDO_1000010	Sickle Cell Disease-S/HPFH	http://purl.obolibrary.org/obo/SCDO_1000215	Structural and Quantitative Hemoglobinopathy		A group of disorders caused by large deletions of the beta-globin gene complex; typically 30% fetal haemoglobin.
http://purl.obolibrary.org/obo/SCDO_1000012	Beta-Globin Family Members	http://purl.obolibrary.org/obo/SCDO_1000104	Hemoglobin Subunits		Members of the beta-globin family. In humans, they are encoded in a gene cluster on chromosome 11. They include hemoglobin subunit epsilon, hemoglobin subunit gamma, hemoglobin subunit delta and hemoglobin subunit beta. There is also a pseudogene of beta (theta-beta) in the gene cluster. Adult hemoglobin is comprised of two alpha globin chains and two beta-globin chains.
http://purl.obolibrary.org/obo/SCDO_1000013	HBB	http://purl.obolibrary.org/obo/SCDO_1000362	Beta-Globin Gene		This gene encodes the hemoglobin subunit beta and is located on chromosome 11 mapped at 11p15.5.
http://purl.obolibrary.org/obo/SCDO_1000014	HBD	http://purl.obolibrary.org/obo/SCDO_1000362	Beta-Globin Gene		This gene encodes the hemoglobin subunit delta, which is a component of hemoglobin A2, which plays a role in the transport of oxygen to tissues of the adult body, but exists only in small amounts in all adult humans (1.5-3.1% of all hemoglobin molecules).
http://purl.obolibrary.org/obo/SCDO_1000016	Hemoglobin O-Arab	http://purl.obolibrary.org/obo/SCDO_0003807	Abnormal Hemoglobin		An abnormal hemoglobin that results from the substitution of glutamic acid with lysine at position 121 of the beta chain.
http://purl.obolibrary.org/obo/SCDO_1000017	Surgery	http://purl.obolibrary.org/obo/SCDO_0001133	Symptomatic Therapeutics		A material processing technique that uses operative manual and instrumental techniques on a patient to investigate and/or treat a pathological condition such as disease or injury or to help improve bodily function or appearance.
http://purl.obolibrary.org/obo/SCDO_1000020	Treatment of Precipitating Factors	http://purl.obolibrary.org/obo/SCDO_0001152	Therapeutics		Treatment of factors associated with the definitive onset of a disease, illness, accident, behavioral response, or course of action. Usually one factor is more important or more obviously recognizable than others, if several are involved, and one may often be regarded as necessary. Examples include exposure to specific disease; amount or level of an infectious organism, drug, or noxious agent, etc.
http://purl.obolibrary.org/obo/SCDO_1000023	obsolete Evidence Code	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		'Every annotation must be attributed to a source, which may be a literature reference, another database or a computational analysis. The annotation must indicate what kind of evidence is found in the cited source to support the association between the gene product and the GO term. A simple controlled vocabulary is used to record evidence; and the evidence codes are simply the three-letter codes used to signify the type of evidence cited. [Curator team: Exact []]'
http://purl.obolibrary.org/obo/SCDO_1000024	obsolete IEA (inferred from electronic annotation)	http://purl.obolibrary.org/obo/SCDO_1000023	obsolete Evidence Code		'Used for annotations that depend directly on computation or automated transfer of annotations from a database, particularly when the analysis is performed internally and not published. A key feature that distinguishes this evidence code from others is that it is not made by a curator; use IEA when no curator has checked the specific annotation to verify its accuracy. [Curator team: Exact []]'
http://purl.obolibrary.org/obo/SCDO_1000025	obsolete PCS (published clinical study)	http://purl.obolibrary.org/obo/SCDO_1000023	obsolete Evidence Code		'This should be used for information extracted from articles in the medical literature. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_1000026	obsolete ICE (individual clinical experience)	http://purl.obolibrary.org/obo/SCDO_1000023	obsolete Evidence Code		'Can be used for annotations based on individual clinical experience. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_1000027	obsolete ITM (inferred by text-mining)	http://purl.obolibrary.org/obo/SCDO_1000023	obsolete Evidence Code		'Not described [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_1000028	obsolete TAS (traceable author statement)	http://purl.obolibrary.org/obo/SCDO_1000023	obsolete Evidence Code		'Usually reviews or disease entries (e.g. OMIM) that only refers to the original publication. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_1000029	obsolete NAS (non-traceable author statement)	http://purl.obolibrary.org/obo/SCDO_1000023	obsolete Evidence Code		'used in all cases where the author makes a statement that a curator wants to capture but for which there are neither results presented nor a specific reference cited in the source used to make the annotation. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_1000030	obsolete IC (inferred by curator)	http://purl.obolibrary.org/obo/SCDO_1000023	obsolete Evidence Code		'Used for those cases where an annotation is not supported by any direct evidence, but can be reasonably inferred by a curator from other annotations, for which evidence is available. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_1000031	from personal attribute	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		Terms deprecated in the "Personal Attribute" class.
http://purl.obolibrary.org/obo/SCDO_1000032	Diagnostic Tool	http://purl.obolibrary.org/obo/SCDO_0000379	Diagnostics		A diagnostic instrument, technique, laboratory assay or test, or method of patient examination used for differential diagnosis.
http://purl.obolibrary.org/obo/SCDO_1000033	Diagnostic Instrument	http://purl.obolibrary.org/obo/SCDO_1000032	Diagnostic Tool		A research instrument consisting of a series of questions and other prompts for the purpose of gathering information from respondents to assist with differential diagnosis.
http://purl.obolibrary.org/obo/SCDO_1000034	from diagnostics	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		Terms deprecated in the "Diagnostics" class.
http://purl.obolibrary.org/obo/SCDO_1000035	from therapeutics	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		Terms deprecated in the "Therapeutics" class.
http://purl.obolibrary.org/obo/SCDO_1000036	Hemoglobin C Present	http://purl.obolibrary.org/obo/HP_0020061	Abnormal Hemoglobin Concentration		When the abnormal hemoglobin, hemoglobin C (HbC), has been detected in a blood sample.
http://purl.obolibrary.org/obo/SCDO_1000037	Abnormality of the Cerebral Vasculature	http://purl.obolibrary.org/obo/HP_0002597	Abnormality of the Vasculature		An abnormality of the cerebral vasculature.
http://purl.obolibrary.org/obo/SCDO_1000038	SCD Causal Mutation	http://purl.obolibrary.org/obo/IDOMAL_50000026	Mutation		A mutation wholly or partly responsible for causing a sickle cell disease.
http://purl.obolibrary.org/obo/SCDO_1000039	HBB, GLU6VAL	http://purl.obolibrary.org/obo/SCDO_1000038	SCD Causal Mutation		The glutamic acid in position 6 in the primary sequence of a beta-chain produced by the HBB gene is replaced by valine.
http://purl.obolibrary.org/obo/SCDO_1000040	HBB, GLU121LYS	http://purl.obolibrary.org/obo/SCDO_0009786	Other HBB Variants		A mutation where the glutamic acid in position 121 in the primary sequence of a beta-chain produced by the HBB gene is replaced by lysine. This mutation is found as a single alteration in Hemoglobin O-Arab and is one of the two contributing mutations to the production of Hemoglobin S-Oman.
http://purl.obolibrary.org/obo/SCDO_1000041	HBB, GLU6LYS	http://purl.obolibrary.org/obo/SCDO_0009786	Other HBB Variants		A mutation where the glutamic acid in position 6 in the primary sequence of a beta-chain produced by the HBB gene is replaced by lysine. This mutation results in the production of Hemoglobin C and confers resistance to malaria.
http://purl.obolibrary.org/obo/SCDO_1000042	HBB, GLU26LYS	http://purl.obolibrary.org/obo/SCDO_0001765	Beta-Minus Thalassemia Mutation		A mutation in the HBB gene causing substitution of glutamic acid for lysine at the 26th position of the beta-globin chain.
http://purl.obolibrary.org/obo/SCDO_1000043	Gender Identity	http://purl.obolibrary.org/obo/NCIT_C19332	Personal Attribute		A person's concept of self as being male and masculine or female and feminine, or ambivalent, based in part on physical characteristics, parental responses, and psychological and social pressures. It is the internal experience of gender role.
http://purl.obolibrary.org/obo/SCDO_1000044	HBB, ASP73ASN	http://purl.obolibrary.org/obo/SCDO_0009786	Other HBB Variants		A mutation where the aspartic acid in position 73 in the primary sequence of a beta-chain produced by the HBB gene is replaced by asparagine. This mutation is found as a single alteration in Hemoglobin Korle Bu and is one of the two contributing mutations to the production of Hemoglobin C-Harlem.
http://purl.obolibrary.org/obo/SCDO_1000045	HBB, VAL23ILE	http://purl.obolibrary.org/obo/SCDO_0009786	Other HBB Variants		A mutation where the valine in position 23 in the primary sequence of a beta-chain produced by the HBB gene is replaced by isoleucine. When compounded with the HbS mutation in the same gene, the sickling Hemoglobin S-Antilles is produced.
http://purl.obolibrary.org/obo/SCDO_1000046	HBB, THR87ILE	http://purl.obolibrary.org/obo/SCDO_0009786	Other HBB Variants		A mutation where the threonine in position 87 in the primary sequence of a beta-chain produced by the HBB gene is replaced by isoleucine. This mutation is found as a single alteration in Hemoglobin Quebec-Chori. Compound heterozygosity for Hb Quebec-chori and Hb S results in sickle cell disease.
http://purl.obolibrary.org/obo/SCDO_1000047	HBB, LEU68PHE	http://purl.obolibrary.org/obo/SCDO_0009786	Other HBB Variants		A mutation where the leusine residue in position 6 in the primary sequence of a beta-chain produced by the HBB gene is replaced by phenylalanine. This mutation on its own produces a stable hemoglobin that does not result in hemolysis (Hb Rockford), but when in combination with the Hb S mutation (HBB, GLU6VAL), the symptomatic Hb Jamaica Plain is produced.
http://purl.obolibrary.org/obo/SCDO_1000048	SCD Genotype	http://purl.obolibrary.org/obo/SCDO_0004061	Genotype		The alleles, or variant forms of the HBB gene, that are carried by an SCD sufferer.
http://purl.obolibrary.org/obo/SCDO_1000049	Hemoglobin Genotype SC	http://purl.obolibrary.org/obo/SCDO_1000048	SCD Genotype		The genotype when an individual has the Hb C gene from one parent and the Hb S gene from the other. Individuals with Hb SC have similar symptoms to individuals with Hb SS, however, the anemia is less severe.
http://purl.obolibrary.org/obo/SCDO_1000051	Hemoglobin Genotype S/O-Arab	http://purl.obolibrary.org/obo/SCDO_1000048	SCD Genotype		Compound heterozygosity for the hemoglobin S (HBB Glu6Val) and hemoglobin O-Arab (HBB GluU121Lys) variants.
http://purl.obolibrary.org/obo/SCDO_1000052	Hemoglobin Genotype SE	http://purl.obolibrary.org/obo/SCDO_1000048	SCD Genotype		Compound heterozygosity for the hemoglobin S (HBB Glu6Val) and hemoglobin E (HBB Glu26Lys) variants.
http://purl.obolibrary.org/obo/SCDO_1000053	Hemoglobin Genotype SS	http://purl.obolibrary.org/obo/SCDO_1000048	SCD Genotype		The homozygous genotype that involves a substitution of glutamic acid for a valine at position 6 of beta-globin chains produced by both beta-globin gene (HBB) alleles.
http://purl.obolibrary.org/obo/SCDO_1000054	Hemoglobin Genotype SD	http://purl.obolibrary.org/obo/SCDO_1000048	SCD Genotype		Compound heterozygous inheritance of Hb S and Hb D mutations. Hb S occurs from substitution of valine for glutamic acid in the beta-6 position (beta6Glu>Val). Hb D generally results from substitution of glutamic acid for glutamine at beta-121 (beta121Glu>Gln); such as the Hb D-Punjab/Hb D-Los Angeles variants. There are several other Hb D variants, including Hb D-Iband where threonine is substituted by lysine at beta-87 (beta87Thr>Lys) and Hb D-Iran where glutamic acid is substituted by glutamine at beta-22 (beta22Glu>Gln).
http://purl.obolibrary.org/obo/SCDO_1000056	Hemoglobin Genotype S/C-Harlem	http://purl.obolibrary.org/obo/SCDO_1000048	SCD Genotype		Compound heterozygous inheritance of Hb S and Hb C-Harlem mutations. Hb S occurs from substitution of valine for glutamic acid in the beta-6 position (beta6Glu>Val). Hb C-Harlem involves two substitutions in each beta-chain: the first being identical to that found in Hb S, and the second being a substitution of aspartic acid at position 73 by asparagine (beta73Asp>Asn).
http://purl.obolibrary.org/obo/SCDO_1000058	Hemoglobin C-Harlem	http://purl.obolibrary.org/obo/SCDO_1000082	Sickling Hemoglobin with Two Beta-Globin Gene Substitutions		An abnormal hemoglobin in which two mutations occur in its beta-chains results in the sickling of red blood cells containing this hemoglobin. The sickling is the result of the mutation in which glutamic acid in position 6 is replaced by valine, which is not counteracted by the second mutation, in which the aspartic acid in position 73 is replaced by asparagine.
http://purl.obolibrary.org/obo/SCDO_1000059	Hemoglobin D-Punjab Trait	http://purl.obolibrary.org/obo/SCDO_0000525	Hemoglobin D Trait		The inheritance of the gene for hemoglobin D-Punjab from one parent and a gene for normal adult hemoglobin (hemoglobin A) from the other parent.
http://purl.obolibrary.org/obo/SCDO_1000060	SCD Molecular Phenotype	http://purl.obolibrary.org/obo/SCDO_0007623	Molecular Phenotype		The underlying molecular makeup resulting in sickle cell disease.
http://purl.obolibrary.org/obo/SCDO_1000061	Altered Level of Normal Hemoglobin in SCD	http://purl.obolibrary.org/obo/SCDO_1000276	Abnormal Hemoglobin Level in SCD		An altered level of normal hemoglobin (Hemoglobin A (Hb A), Hemoglobin A2 (Hb A2) or Hemoglobin F (Hb F, fetal hemoglobin) in the blood, which may be seen in those suffering with Sickle Cell Disease (SCD).
http://purl.obolibrary.org/obo/SCDO_1000062	Sickle Cell Disease-S/C-Harlem	http://purl.obolibrary.org/obo/SCDO_1000163	Compound Heterozygous Sickle Cell Disease		A rare type of sickle cell disease with the compound heterozygous genotype involving the mutations for Hemoglobin S and Hemoglobin C-Harlem. This condition is described to have a clinical course similar to sickle cell anemia.
http://purl.obolibrary.org/obo/SCDO_1000063	HBB, 106-KB DEL	http://purl.obolibrary.org/obo/SCDO_0009786	Other HBB Variants		A 106-kb deletion of the beta globin gene cluster.
http://purl.obolibrary.org/obo/SCDO_1000064	Tiered Consent	http://purl.obolibrary.org/obo/NCIT_C25460	Consent		A consent model in which participants are given a set of options allowing them to select how they want to participate in the research.
http://purl.obolibrary.org/obo/SCDO_1000065	Specific Consent	http://purl.obolibrary.org/obo/SCDO_0007087	Informed Consent		Requires that consent to the use of human samples be specific to the 'purpose' for which the sample is to be used and that where previously collected samples are to be used for a different 'research purpose' further consent should generally be obtained.
http://purl.obolibrary.org/obo/SCDO_1000066	Hemoglobin F Test	http://purl.obolibrary.org/obo/SCDO_0000522	Hemoglobin Variant Test		The determination of the amount of hemoglobin F present in a sample.
http://purl.obolibrary.org/obo/SCDO_1000068	deprecated Severe S/Beta-Plus-Thal	http://purl.obolibrary.org/obo/SCDO_1000091	deprecated Sickle beta plus thalassemia		'Genotype where a person is a compound heterozygote for the hemoglobin S mutation and a severe beta plus thalassemia mutation. Source: CLAIR [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_1000069	Hemoglobin Genotype S/HPFH	http://purl.obolibrary.org/obo/SCDO_1000048	SCD Genotype		Genotype whereby a person is heterozygous for a hemoglobin S mutation and heterozygous for a mutation that causes persistant fetal hemoglobin production into adulthood. HPFH causative mutations are largely due to deletions in the beta-globin locus, but also by point mutations in the gamma-globin gene promoters.
http://purl.obolibrary.org/obo/SCDO_1000070	Hemoglobin Genotype S/Lepore Boston	http://purl.obolibrary.org/obo/SCDO_1000107	Hemoglobin Genotype S/Beta Thalassemia		A compound heterozygous genotype, involving the mutations for Hemoglobin S (beta6Glu>Val) and Hemoglobin Lepore Boston.
http://purl.obolibrary.org/obo/SCDO_1000071	Hemoglobin Genotype A/Jamaica Plain	http://purl.obolibrary.org/obo/SCDO_1000048	SCD Genotype		A genotype that involves a double mutation in one beta-globin gene that results in hemoglobin with low oxygen affinity, which results in the polymerisation of the hemoglobin variant (hemoglobin Jamaica Plain) and thus sickling of erythorcytes.
http://purl.obolibrary.org/obo/SCDO_1000072	Hemoglobin Jamaica Plain	http://purl.obolibrary.org/obo/SCDO_1000082	Sickling Hemoglobin with Two Beta-Globin Gene Substitutions		A sickling hemoglobin with reduced oxygen affinity that causes severe hemolytic anemia and sickling of erythrocytes.
http://purl.obolibrary.org/obo/SCDO_1000073	Hemoglobin S-Antilles	http://purl.obolibrary.org/obo/SCDO_1000082	Sickling Hemoglobin with Two Beta-Globin Gene Substitutions		A form of hemoglobin caused by two mutations in its beta-chains, the classic beta S mutation (beta 6 Glu>Val) and beta 23 Val>Ile. Hemoglobin S-Antilles has the same electrophoretic mobility as Hemoglobin S but a distinct isoelectric focus and produces sickling in the carriers of the Hb A/S Antilles trait.
http://purl.obolibrary.org/obo/SCDO_1000074	Hemoglobin S-Oman	http://purl.obolibrary.org/obo/SCDO_1000082	Sickling Hemoglobin with Two Beta-Globin Gene Substitutions		A form of hemoglobin caused by two mutations in a beta-globin chain, the classic beta S mutation (beta6 Glu> Val) and a beta121 Glu > Lys mutation identical to that of Hb-O Arab. The hemoglobin variant has reduced solubility and there is an apparent increase in red cell sickling tendency. It is reported to cause a rare dominant form of sickle cell disease, Sickle Cell Disease A/S-Oman.
http://purl.obolibrary.org/obo/SCDO_1000075	Hemoglobin Genotype A/S-Oman	http://purl.obolibrary.org/obo/SCDO_1000048	SCD Genotype		Dominant heterozygosity for the double HBB Glu6Val and Glu121Lys mutation.
http://purl.obolibrary.org/obo/SCDO_1000076	Mild Sickle Cell Disease-S Beta Minus Thalassemia	http://purl.obolibrary.org/obo/SCDO_0001056	Sickle Cell Disease-S Beta Minus Thalassemia		A form of sickle cell thalassemia, with a mild clinical phenotype, characterized by the presence of hemoglobin S and a small amount of hemoglobin A in the red blood cells.
http://purl.obolibrary.org/obo/SCDO_1000077	Moderate Sickle Cell Disease-S Beta Minus Thalassemia	http://purl.obolibrary.org/obo/SCDO_0001056	Sickle Cell Disease-S Beta Minus Thalassemia		A form of sickle cell thalassemia, with a moderate clinical phenotype, characterized by the presence of hemoglobin S and a small amount of hemoglobin A in the red blood cells.
http://purl.obolibrary.org/obo/SCDO_1000078	Severe Sickle Cell Disease-S Beta Minus Thalassemia	http://purl.obolibrary.org/obo/SCDO_0001056	Sickle Cell Disease-S Beta Minus Thalassemia		A form of sickle cell thalassemia, with a severe clinical phenotype, characterized by the presence of hemoglobin S and a small amount of hemoglobin A in the red blood cells.
http://purl.obolibrary.org/obo/SCDO_1000079	deprecated Moderate S/Beta-Plus-Thal	http://purl.obolibrary.org/obo/SCDO_1000091	deprecated Sickle beta plus thalassemia		'Genotype where a person is a compound heterozygote for the hemoglobin S mutation and a moderate beta plus thalassemia mutation. Source: CLAIR [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_1000080	deprecated Mild S/Beta-Plus-Thal	http://purl.obolibrary.org/obo/SCDO_1000091	deprecated Sickle beta plus thalassemia		'Not described [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_1000081	Hemoglobin Genotype C/S Antilles	http://purl.obolibrary.org/obo/SCDO_1000048	SCD Genotype		Compound heterozygosity for the hemoglobin C (HBB Glu6Lys) mutation and the double HBB Glu6Val, Val23Ile mutation of hemoglobin S-Antilles.
http://purl.obolibrary.org/obo/SCDO_1000082	Sickling Hemoglobin with Two Beta-Globin Gene Substitutions	http://purl.obolibrary.org/obo/SCDO_0003807	Abnormal Hemoglobin		A hemoglobin that sickles due to the presence of two beta-globin gene mutations within the same HBB gene.
http://purl.obolibrary.org/obo/SCDO_1000083	Hemoglobin S-South End	http://purl.obolibrary.org/obo/SCDO_1000082	Sickling Hemoglobin with Two Beta-Globin Gene Substitutions		An abnormal hemoglobin in which two mutations occurring in its beta-chains results in the sickling of red blood cells containing this hemoglobin. The sickling is the result of the mutation in which glutamic acid in position 6 is replaced by valine, which is not counteracted by the second mutation, in which the lysine in position 132 is replaced by asparagine.
http://purl.obolibrary.org/obo/SCDO_1000084	Hemoglobin Genotype S/Quebec-Chori	http://purl.obolibrary.org/obo/SCDO_1000048	SCD Genotype		A compound heterozygous genotype, involving the mutations for Hemoglobin S and Hemoglobin Quebec Chori, which shows an electrophoretic pattern similar to that of the Hb A/S Genotype, but shows sickling.
http://purl.obolibrary.org/obo/SCDO_1000085	Hemoglobin Quebec Chori	http://purl.obolibrary.org/obo/SCDO_0003807	Abnormal Hemoglobin		An abnormal hemoglobin in which a threonine is replaced by an isoleucine residue at the eighty-seventh position of beta chains. It migrates like HbA but promotes sickling.
http://purl.obolibrary.org/obo/SCDO_1000086	Sickle Cell Disease-S/Quebec Chori	http://purl.obolibrary.org/obo/SCDO_1000163	Compound Heterozygous Sickle Cell Disease		A severe compound heterozygous sickling disorder characterized by the presence of both hemoglobin S and hemoglobin Quebec Chori.
http://purl.obolibrary.org/obo/SCDO_1000087	HBB, LYS132ASN	http://purl.obolibrary.org/obo/SCDO_0009786	Other HBB Variants		A mutation where the lysine residue in position 132 in the primary sequence of a beta-chain produced by the HBB gene is replaced by asparagine. This mutation on its own produces Hb Yamagata which has reduced oxygen affinity, but no distinctive clinical abnormalities. However, when present in the same gene as the Hb S mutation (HBB, GLU6VAL), the sickling HbS-South End is produced.
http://purl.obolibrary.org/obo/SCDO_1000088	Hemoglobin Genotype S/S-South End	http://purl.obolibrary.org/obo/SCDO_1000048	SCD Genotype		A compound heterozygous genotype, involving the mutations for hemoglobin S and hemoglobin S-South End.
http://purl.obolibrary.org/obo/SCDO_1000089	Hemoglobin Lepore Boston	http://purl.obolibrary.org/obo/SCDO_0003807	Abnormal Hemoglobin		The most common Hemoglobin Lepore type and the only type of the three known variants described in association with HbS. This abnormal hemoglobin consists of two normal alpha globin chains (HBA) and two deltabeta globin fusion chains which occur due to a crossover between the delta (HBD) and beta globin (HBB) gene loci during meiosis.
http://purl.obolibrary.org/obo/SCDO_1000090	Sickle Cell Disease-S/S-South End	http://purl.obolibrary.org/obo/SCDO_1000163	Compound Heterozygous Sickle Cell Disease		A rare, reported severe, type of sickle cell disease with the compound heterozygous genotype involving the mutations for Hemoglobin S and Hemoglobin S-South End.
http://purl.obolibrary.org/obo/SCDO_1000091	deprecated Sickle beta plus thalassemia	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		'Sb+ thalassemia is an inherited condition. Hemoglobin S comes from one parent and Beta plus thalassemia comes from the other parent. Instead of appearing round (like donuts), red blood cells are somewhat small, pale and misshapen. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_1000092	deprecated-Acute Severe Headache	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		A primary headache disorder that is characterized by severe, strictly unilateral PAIN which is orbital, supraorbital, temporal or in any combination of these sites, lasting 15-180 min. occurring 1 to 8 times a day. The attacks are associated with one or more of the following, all of which are ipsilateral: conjunctival injection, lacrimation, nasal congestion, rhinorrhea, facial SWEATING, eyelid EDEMA, and miosis.
http://purl.obolibrary.org/obo/SCDO_1000093	Adverse Event (AE)	http://purl.obolibrary.org/obo/SCDO_0000391	Disease Modifier		A medically undesirable event occurring in a research subject, such as an abnormal sign, symptom, worsening of a disease, injury, etc. A serious adverse event (SAE) results in death, hospitalization (or increased hospital stay), persistent disability, birth defect, or any other outcome that seriously jeopardizes the subject's health.
http://purl.obolibrary.org/obo/SCDO_1000094	Research Benefit	http://purl.obolibrary.org/obo/SCDO_0300005	Research Characteristics		A desirable research outcome or state of affairs, such as medical treatment, clinically useful information, or self-esteem. In the oversight of human subjects research, money is usually not treated as a benefit.
http://purl.obolibrary.org/obo/SCDO_1000095	Conflict of Interest	http://purl.obolibrary.org/obo/SCDO_1000430	Ethics Related Concept		A situation in which an individual or their close associates might benefit personally from official or professional actions. It includes a conflict between a person's private interests and official responsibilities in a position of trust.The concept refers both to actual conflict of interest and the appearance or perception of conflict.
http://purl.obolibrary.org/obo/SCDO_1000097	Human Subject	http://purl.obolibrary.org/obo/SCDO_0300005	Research Characteristics		An homo sapiens that bears an experimental subject role which is realized through his/her participation in a scientific technique as the subject of interest (ie as the subject about which data is generated in an assay or study, or the entity that is transformed or modified in a material processing technique).
http://purl.obolibrary.org/obo/SCDO_1000098	Case Report Form (CRF)	http://purl.obolibrary.org/obo/SCDO_0300003	Publication Formats		A paper or electronic questionnaire specifically used in research by the sponsor of the research to collect data from each research participant. All data on each participant in the study are held and/or documented in the CRF, including adverse events.
http://purl.obolibrary.org/obo/SCDO_1000099	Modifier Gene	http://purl.obolibrary.org/obo/SCDO_0000444	Genetic Disease Modifier		Genes with alleles that affect the phenotype associated with a nonallelic gene.
http://purl.obolibrary.org/obo/SCDO_1000100	ICD-10-CM Code Type	http://purl.obolibrary.org/obo/SCDO_0000245	Clinical Coding		The type of ICD-10-CM code, in terms of a code's usability for reimbursement purposes.
http://purl.obolibrary.org/obo/SCDO_1000103	Genetic Locus	http://purl.obolibrary.org/obo/SCDO_0005722	Genetic Structure		A specific region that is mapped within a genome. Genetic loci are usually identified with a shorthand notation that indicates the chromosome number and the position of a specific band along the P or Q arm of the chromosome where they are found. For example the locus 6p21 is found within band 21 of the P-arm of CHROMOSOME 6. Many well known genetic loci are also known by common names that are associated with a genetic function or hereditary disease.
http://purl.obolibrary.org/obo/SCDO_1000104	Hemoglobin Subunits	http://purl.obolibrary.org/obo/NCIT_C26548	Gene Product		The protein subunits that comprise multimeric hemoglobins.
http://purl.obolibrary.org/obo/SCDO_1000105	Alpha-Globin Family Members	http://purl.obolibrary.org/obo/SCDO_1000104	Hemoglobin Subunits		Members of the alpha-globin family. In humans, they are encoded in a gene cluster on chromosome 16. They include hemoglobin subunit zeta and hemoglobin subunit alpha. There are also pseudogenes of zeta (theta-zeta) and alpha (theta-alpha) in the cluster. Adult hemoglobin is comprised of 2 alpha-globin chains and 2 beta-globin chains.
http://purl.obolibrary.org/obo/SCDO_1000106	Sickle Cell Disease	http://purl.obolibrary.org/obo/SCDO_0000552	Hemoglobinopathy		Sickle cell disease (SCD) is a pleiotropic inherited disorder of the blood, characterised by the appearance of sickle-shaped red blood cells and anemia. It results from homozygosity for the sickle beta-globin gene mutation at position 6 (glu > val), or compound heterozygosity for the sickle gene and either another mutation for a different hemoglobin variant or one of numerous beta-thalassemia
 mutations.
http://purl.obolibrary.org/obo/SCDO_1000107	Hemoglobin Genotype S/Beta Thalassemia	http://purl.obolibrary.org/obo/SCDO_1000048	SCD Genotype		The combination of the hemoglobin S mutation (beta6Glu>Val) and a beta-thalassemia mutation.
http://purl.obolibrary.org/obo/SCDO_1000108	HBB, SER9TYR	http://purl.obolibrary.org/obo/SCDO_0002305	Hemoglobin D Disease Causal Mutation		A mutation where the serine in position 9 in the primary sequence of a beta-chain produced by the HBB gene is replaced by tyrosine. This mutation is one of 2 amino acid substitutions in the same beta chain that produces the asymptomatic Hemoglobin D-Agri, the other mutation being HBB, GLU121GLN, which on its own produces Hemoglobin D-Punjab.
http://purl.obolibrary.org/obo/SCDO_1000109	HBB, GLU121GLN	http://purl.obolibrary.org/obo/SCDO_0009786	Other HBB Variants		A mutation where the glutamic acid in position 121 in the primary sequence of a beta-chain produced by the HBB gene is replaced by glutamine.
http://purl.obolibrary.org/obo/SCDO_1000110	HBB, GLY16ARG	http://purl.obolibrary.org/obo/SCDO_0002305	Hemoglobin D Disease Causal Mutation		A mutation where the glycine in position 16 in the primary sequence of a beta-chain produced by the HBB gene is replaced by arginine.
http://purl.obolibrary.org/obo/SCDO_1000111	HBB, ASN19LYS	http://purl.obolibrary.org/obo/SCDO_0002305	Hemoglobin D Disease Causal Mutation		A mutation where the asparargine acid in position 19 in the primary sequence of a beta-chain produced by the HBB gene is replaced by lysine.
http://purl.obolibrary.org/obo/SCDO_1000112	HBB, GLU22GLN	http://purl.obolibrary.org/obo/SCDO_0002305	Hemoglobin D Disease Causal Mutation		A mutation where the glutamic acid in position 22 in the primary sequence of a beta-chain produced by the HBB gene is replaced by glutamine.
http://purl.obolibrary.org/obo/SCDO_1000115	HBB, GLU121ALA	http://purl.obolibrary.org/obo/SCDO_0002305	Hemoglobin D Disease Causal Mutation		A mutation where the glutamic acid in position 121 in the primary sequence of a beta-chain produced by the HBB gene is replaced by alanine.
http://purl.obolibrary.org/obo/SCDO_1000116	Adja	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		The Adja ethnic group are mostly farmers and live in the southern part of Benin Republic. They make up 15% of the general country population. This group of people migrated into Benin between the 12th and 13th centuries from River Mono. The primary language is Aja-Gbe with a majority of the people being trilingual.
http://purl.obolibrary.org/obo/SCDO_1000117	Bariba	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		Bariba is the ethnic group dominating the northern side of Benin, who constitute 9% of the population. They are the first inhabitants of Benin and are concentrated in the capital city, Nikki. One of their leading practices is horse riding, which is a practice that has been enjoyed from generation to generation. With agriculture being their dominant occupation, Bariba people have a diverse range of produce such as corn, rice and palm oil.
http://purl.obolibrary.org/obo/SCDO_1000119	Fon	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		The largest ethnic group in Benin is Fon/Dahomey which constitutes 39% of the total population. Established in 1600 by the Fon, a group that came about through the intermarriage between the Adja and local Gedevi.
http://purl.obolibrary.org/obo/SCDO_1000122	Embu	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		The Embu are a Bantu-speaking people who are closely related to the Gikuyu of Ndia and Gicugu to the west, the Mbeere and the Kamba to the southeast, and the Chuka and the Meru to the north in Kenya.
http://purl.obolibrary.org/obo/SCDO_1000123	Kalenjin	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		The Kalenjin ethnic group are one of the five largest ethnic groups in Kenya. They are a Nilotic ethnic group and they are mainly farmers.
http://purl.obolibrary.org/obo/SCDO_1000124	Kamba	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		The Kamba ethnic group, also known as Akamba is one of the five largest ethnic groups in Kenya. They are Bantu-speaking people and primarily agriculturists.
http://purl.obolibrary.org/obo/SCDO_1000125	Kikuyu	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		The Kikuyu are the largest single ethnic tribe in Kenya, making up 22% of the country's population. It is believed that the Kikuyu people migrated from Lake Chad to East Africa in 1000 AD, settling in the fertile central highlands of Kenya and engaging in farming.
http://purl.obolibrary.org/obo/SCDO_1000126	Kisii	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		The Kisii tribe (also known as the Gusii tribe) is a Bantu ethnic group who occupy the Kisii highlands in Nyanza, Western Kenya. The Kisiis constitute the sixth largest ethnic group, comprising about seven percent of the national population. Kisii, which is their ethnic language, is also traditionally known as Ekegusii.
http://purl.obolibrary.org/obo/SCDO_1000127	Luhya	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		The Luhya ethnic group, also known as the Abaluhya, Baluhya, or Abaluyia, is a Bantu tribe living in Kenya's agriculturally fertile western region. They are the second largest tribe in Kenya and neighbors to some of the Nilotic tribes, including the Luo, Kalenjin, Maasai and Teso (Iteso).
http://purl.obolibrary.org/obo/SCDO_1000128	Luo	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		Luo, also called Joluo or Kavirondo constitute the fourth largest ethnic group in Kenya. The Luo speak a Nilotic language of the Nilo-Saharan language family.
http://purl.obolibrary.org/obo/SCDO_1000129	Maasai	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		A smaller ethnic group, accounting for only about 0.7 percent of Kenya's population, with a similar number living in Tanzania. Maasais speak Maa, a Nilotic ethnic language from their origin in the Nile region of North Africa.
http://purl.obolibrary.org/obo/SCDO_1000131	Yoruba	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		Yoruba is an ethnic group coming from Nigeria and well settled along the eastern boundary of Benin. They are more than 18% of the population. The majority of the Yoruba people in Benin are descendants of the Ife tribe, and the Yoruba people are predominantly of the Muslim religion.
http://purl.obolibrary.org/obo/SCDO_1000132	Meru	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		The Meru tribe or Merus is a Bantu ethnic group. They reside on Mount Kenya's agriculturally rich northeastern slopes, in Kenya's Eastern Province. The name Meru refers to both the people and the location. Merus are primarily agrarian, raising a few domestic animals.
http://purl.obolibrary.org/obo/SCDO_1000133	Mijikenda/Swahili	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		The Mijikenda tribe is a Kenyan coastal Bantu tribe that consists of nine closely related sub-tribes. "Mijikenda" literally means nine homes or nine homesteads (in Swahili), referring to the common ancestry of the Mijikenda people. The nine Mijikenda sub-tribes are believed to be nine different homes of the same tribe. Each sub-tribe speaks its own dialect of the Mijikenda language.
http://purl.obolibrary.org/obo/SCDO_1000134	Somali	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		A Cushitic speaking people comprising a small minority of Kenya's population. The Somali tend large herds of cattle, goats, sheep, and camels in the dry, arid lands of Northern Kenya. They are politically well organized and are united by both family allegiances and political treaties. The Somali also produce exquisitely carved headrests and woven artifacts.
http://purl.obolibrary.org/obo/SCDO_1000135	Taita/Taveta	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		The Taita people are a Bantu tribe living in the Taita Hills on Kenya's southwest, near the Tanzania border and surrounding plains. Taita tribe actually consists of three separate but closely-related tribes: Wadawida (or Taita), Wasaghala (Sagalla) and Wataveta (Taveta).
http://purl.obolibrary.org/obo/SCDO_1000136	Borana	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		The  Borana  are  a  branch  of  the  populous  Oromo  people  found  in  southern  Ethiopia and  northern  Kenya.
http://purl.obolibrary.org/obo/SCDO_1000137	Maragoli	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		It is the second largest sub-tribe of the Luhya ethnic group in Kenya.
http://purl.obolibrary.org/obo/SCDO_1000138	Pokot	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		The Pokot are a Kalenjin-speaking people whose language incorporates words from the neighboring Karamojong and Turkana. The Pokot live in an ecologically complex region that extends from the plains of eastern Uganda across the highlands of northwestern Kenya to the plains of Lake Baringo.
http://purl.obolibrary.org/obo/SCDO_1000139	Turkana	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		The Turkana tribe is a nomadic pastoralist people that inhabit the Turkana district in Kenya's Rift Valley Province. Turkana tribe is part of the Nilotic tribes and constitutes the second largest pastoralist community in Kenya after the Maasais. They speak the Turkana language, which is Nilotic and similar to the Maasai language.
http://purl.obolibrary.org/obo/SCDO_1000141	Bassa	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		Bassa is a Niger-Congo Kru language. Historians have traced the Bassa's origins back to Egypt nearly six thousand years ago. Due to their migration from Egypt to other parts of Africa, the Bassa in Liberia share a similar history with Bassa groups in other parts  of   the continent such as Nigeria (Bassa  Nge), The Democratic Republic of  the Congo (Bassaa la Mpasu), Togo (Basa'r), Senegal (Bassa-Ri), and Cameroon (Basaa Mpoo).
http://purl.obolibrary.org/obo/SCDO_1000142	Spectrophotometry	http://purl.obolibrary.org/obo/SCDO_0000896	Physical Detection Method		Spectrophotometry involves the use of a spectrophotometer to measure the amount of light that a sample absorbs. The instrument operates by passing a beam of light through a sample and measuring the intensity of light reaching a detector.
http://purl.obolibrary.org/obo/SCDO_1000143	Disease Management Guideline	http://purl.obolibrary.org/obo/SCDO_1000160	Guideline		A recommendation on the appropriate treatment and care of people with a specific disease or condition, based on the best available evidence, designed to help healthcare professionals in their work.
http://purl.obolibrary.org/obo/SCDO_1000144	Recommendations for the Management of Sickle Cell Disease in South Africa	http://purl.obolibrary.org/obo/SCDO_1000143	Disease Management Guideline		Management protocols for the purposes of consistency and standardisation, which could also facilitate sharing of resources between centers for maximal utility. These recommendations have been developed for the South African setting, and it is intended to update them regularly to meet new demands and challenges.
http://purl.obolibrary.org/obo/SCDO_1000145	National Guideline for the Control and Management of Sickle Cell Disease	http://purl.obolibrary.org/obo/SCDO_1000143	Disease Management Guideline		Guidelines for the management of specific clinical problems and protocols for various therapeutic procedures for patients with sickle cell disease and thalassaemia; to facilitate uniformity and standardization of care across different disciplines.
http://purl.obolibrary.org/obo/SCDO_1000146	Management of Sickle Cell Disease - The United Republic of Tanzania	http://purl.obolibrary.org/obo/SCDO_1000143	Disease Management Guideline		Guidelines for health care professionals for management of sickle cell disease in patients in the Tanzanian context.
http://purl.obolibrary.org/obo/SCDO_1000147	A Parental Guide to Managing Sickle Cell Disease	http://purl.obolibrary.org/obo/SCDO_1000143	Disease Management Guideline		A booklet with information and standard guidelines to help parents learn about sickle cell disease and how to take care of their children with sickle cell disease.
http://purl.obolibrary.org/obo/SCDO_1000148	Standards for Clinical Care of Adults with Sickle Cell Disease in the UK	http://purl.obolibrary.org/obo/SCDO_1000143	Disease Management Guideline		A document that includes standards and guidelines for clinical care and recommendations for how care for adults with sickle cell disease should be delivered.
http://purl.obolibrary.org/obo/SCDO_1000149	Sickle Cell Disease: The Clinical Care Guidelines of the Sickle Cell Unit	http://purl.obolibrary.org/obo/SCDO_1000143	Disease Management Guideline		The second edition of the Clinical Care Guidelines of the Sickle Cell Unit, containing revised and expanded guidelines for the management of sickle cell disease. It outlines a standard of care that is informed by best practice, taking into account resource limitations locally and regionally. It also contains patient information leaflets.
http://purl.obolibrary.org/obo/SCDO_1000150	Consensus Statement on the Care of Patients with Sickle Cell Disease in Canada	http://purl.obolibrary.org/obo/SCDO_1000143	Disease Management Guideline		Standard of care guidelines that promote excellence in sickle cell care, and that lead to improved patient experiences around care and treatment.
http://purl.obolibrary.org/obo/SCDO_1000151	Sickle Cell Disease in Children, Standards and Guidelines for Clinic Care	http://purl.obolibrary.org/obo/SCDO_1000143	Disease Management Guideline		A document that include standards and guidelines for clinical care and recommendations for how care for children with sickle cell disease should be delivered.
http://purl.obolibrary.org/obo/SCDO_1000152	Evidence-Based Management of Sickle Cell Disease	http://purl.obolibrary.org/obo/SCDO_1000143	Disease Management Guideline		Guidelines providing the best science-based recommendations to guide practice decisions for primary care providers and other clinicians, nurses, and staff who provide emergency or continuity care to individuals with sickle cell disease (SCD). They assist health care professionals in the management of common issues, including routine health maintenance, the recognition and treatment of common acute and chronic complications and comorbidities of SCD, as well as the indications for and monitoring of hydroxyurea and blood transfusion therapy. The guidelines address the care of infants, children, adolescents, and adults with SCD, with the goal of facilitating high-quality and appropriate care for all individuals with this disease.
http://purl.obolibrary.org/obo/SCDO_1000153	Management of Children with Sickle Cell Disease in Europe: Current Situation and Future Perspectives	http://purl.obolibrary.org/obo/SCDO_1000143	Disease Management Guideline		A review of service delivery across Europe to children with sickle cell disease (SCD), reporting on the available minimum standards of care and future perspectives.
http://purl.obolibrary.org/obo/SCDO_1000154	ENERCA Clinical Recommendations for Disease Management and Prevention of Complications of Sickle Cell Disease in Children	http://purl.obolibrary.org/obo/SCDO_1000143	Disease Management Guideline		A document that describes various ways in which sickle cell disease can be managed and its complications can be prevented in children.
http://purl.obolibrary.org/obo/SCDO_1000155	Family Study	http://purl.obolibrary.org/obo/SCDO_0000437	Epidemiologic Studies		Research conducted on members of families, examining the affects of genetics, the environment, or twin offspring.
http://purl.obolibrary.org/obo/SCDO_1000158	Crystallised Hemoglobin	http://purl.obolibrary.org/obo/SCDO_0003807	Abnormal Hemoglobin		Hemoglobin that has undergone conformational changes resulting in increased hydrophobicity that results in the formation of solid crystals consisting of hemoglobin particles.
http://purl.obolibrary.org/obo/SCDO_1000159	Hemoglobin Genotype S/Beta Minus Thalassaemia	http://purl.obolibrary.org/obo/SCDO_1000107	Hemoglobin Genotype S/Beta Thalassemia		When one beta-globin gene carries the hemoglobin S mutation (beta6Glu>Val) whereas the other carries a mutation that reduces the amount of beta-globin chain synthesised.
http://purl.obolibrary.org/obo/SCDO_1000160	Guideline	http://purl.obolibrary.org/obo/SCDO_0001000	SCDO		Work consisting of a set of statements, directions, or principles presenting current or future rules or policy. Guidelines may be developed by government agencies at any level, institutions, organizations such as professional societies or governing boards, or by the convening of expert panels. The text may be cursive or in outline form, but it is generally a comprehensive guide to problems and approaches in any discipline or activity. This concept relates to the general conduct and administration of health care activities rather than to specific decisions for a particular clinical condition.
http://purl.obolibrary.org/obo/SCDO_1000161	Hemoglobin Genotype AS	http://purl.obolibrary.org/obo/SCDO_1000048	SCD Genotype		A genotype whereby one HBB allele produces hemoglobin beta chains for normal adult hemoglobin and the other produces the abnormal hemoglobin beta chains of hemoglobin S. Individuals with this genotype are known to be carriers of the sickle cell trait.
http://purl.obolibrary.org/obo/SCDO_1000162	deprecated-Symptomatic Sickle Cell Trait	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		The condition in which an individual with sickle cell trait shows symptoms of sickle cell disease such as anemia or acute chest syndrome.
http://purl.obolibrary.org/obo/SCDO_1000163	Compound Heterozygous Sickle Cell Disease	http://purl.obolibrary.org/obo/SCDO_0001051	Variant Sickle Cell Syndrome		A hemoglobinopathy in which the sickle mutation (HBB, Glu6Val) is inherited in combination with another beta-globin gene mutation, other thanHBB, Glu6Val.
http://purl.obolibrary.org/obo/SCDO_1000164	Sickle Cell Disease A/Jamaica Plain	http://purl.obolibrary.org/obo/SCDO_1000211	Dominant Sickle Cell Disease		Sickle cell disease caused by two mutations in the same beta globin allele, specifically the sickle cell mutation beta6 Glu > Val and a second beta68 Leu > Phe mutation.The other beta globin allele produces normal beta globin chains.
http://purl.obolibrary.org/obo/SCDO_1000165	Sickle Cell Disease A/S-Oman	http://purl.obolibrary.org/obo/SCDO_1000211	Dominant Sickle Cell Disease		Sickle cell disease caused by two mutations in the same beta globin allele, specifically the sickle cell mutation (beta6 Glu > Val) and the hemoglobin O-Arab mutation (beta121 Glu > Lys). The other beta globin allele produces normal beta globin chains.
http://purl.obolibrary.org/obo/SCDO_1000166	Sickle Cell Disease C/S Antilles	http://purl.obolibrary.org/obo/SCDO_1000211	Dominant Sickle Cell Disease		Sickle cell disease caused by two mutations in the same beta globin allele, specifically the sickle cell mutation beta6 Glu > Val and a second beta 23 Val>Ile mutation. The other beta globin allele produces normal beta globin chains.
http://purl.obolibrary.org/obo/SCDO_1000170	Diagnosis Guideline	http://purl.obolibrary.org/obo/SCDO_1000160	Guideline		A directive information entity that specifies how to establish a diagnosis based on clinical findings.
http://purl.obolibrary.org/obo/SCDO_1000173	Billable ICD-10-CM Code	http://purl.obolibrary.org/obo/SCDO_1000100	ICD-10-CM Code Type		An ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes as there are no codes with a greater level of specificity under each code.
http://purl.obolibrary.org/obo/SCDO_1000174	Non-Billable ICD-10-CM Code	http://purl.obolibrary.org/obo/SCDO_1000100	ICD-10-CM Code Type		An ICD-10-CM diagnosis code that is not billable as there are more specific codes below it that contain a greater level of detail.
http://purl.obolibrary.org/obo/SCDO_1000177	N48.32 Priapism due to disease classified elsewhere	http://purl.obolibrary.org/obo/SCDO_0000607	ICD-10-CM Diagnosis Codes		-
http://purl.obolibrary.org/obo/SCDO_1000178	SickleInAfrica Extended Demographics Data Element	http://purl.obolibrary.org/obo/SCDO_1000508	SickleInAfrica Data Element		A data element in the SickleInAfrica Extended Demographics data capture instrument.
http://purl.obolibrary.org/obo/SCDO_1000179	Absent Hemoglobin E	http://purl.obolibrary.org/obo/SCDO_1000783	Normal Hemoglobin Concentration		A lack of production of hemoglobin E.
http://purl.obolibrary.org/obo/SCDO_1000181	Hemoglobin E Present	http://purl.obolibrary.org/obo/HP_0020061	Abnormal Hemoglobin Concentration		When the abnormal hemoglobin, hemoglobin E (HbE), has been detected in a blood sample.
http://purl.obolibrary.org/obo/SCDO_1000187	Normal Hemoglobin A2 Level	http://purl.obolibrary.org/obo/SCDO_1000783	Normal Hemoglobin Concentration		When the level of hemoglobin A2 detected in a sample of blood falls in the normal range for HbA2.
http://purl.obolibrary.org/obo/SCDO_1000197	HIV Combination Test	http://purl.obolibrary.org/obo/SCDO_0000571	HIV Test		A test to detect both HIV antibodies and HIV antigens (a part of the virus) in blood.
http://purl.obolibrary.org/obo/SCDO_1000198	HIV Nucleic Acid Test	http://purl.obolibrary.org/obo/SCDO_0000571	HIV Test		A test to detect HIV in a person's blood.
http://purl.obolibrary.org/obo/SCDO_1000201	High Level Albuminuria	http://purl.obolibrary.org/obo/SCDO_0000037	Albuminuria		An abnormal albumin excretion rate of more than 300 mg/g urine creatinine.
http://purl.obolibrary.org/obo/SCDO_1000205	Hemoglobin C-Harlem Disease	http://purl.obolibrary.org/obo/SCDO_0008262	Structural Hemoglobinopathy		A clinically severe form of sickle cell disease resulting when a person is homozygous for Hemoglobin C-Harlem.
http://purl.obolibrary.org/obo/SCDO_1000206	Genetic Recombination	http://purl.obolibrary.org/obo/SCDO_0001369	Genetic Variation		Production of new arrangements of DNA by various mechanisms such as assortment and segregation, crossing over; gene conversion; genetic transformation; genetic conjugation; genetic transduction; or mixed infection of viruses.
http://purl.obolibrary.org/obo/SCDO_1000207	Homologous Recombination	http://purl.obolibrary.org/obo/SCDO_1000206	Genetic Recombination		An exchange of DNA between matching or similar sequences.
http://purl.obolibrary.org/obo/SCDO_1000208	Genetic Crossing Over	http://purl.obolibrary.org/obo/SCDO_1000207	Homologous Recombination		The reciprocal exchange of segments at corresponding positions along pairs of homologous chromosomes by symmetrical breakage and crosswise rejoining forming cross-over sites (Holliday junctions) that are resolved during chromosome segregation. Crossing-over typically occurs during meiosis but it may also occur in the absence of meiosis, for example, with bacterial chromosomes, organelle chromosomes, or somatic cell nuclear chromosomes.
http://purl.obolibrary.org/obo/SCDO_1000209	Crossover between delta (HBD) and beta globin (HBB) gene loci	http://purl.obolibrary.org/obo/SCDO_1000208	Genetic Crossing Over		The homologous recombination event that occurs during meiosis and results in the delta beta globin fusion chains that replace hemoglobin subunit beta chains in the abnormal hemoglobin, Hemoglobin Lepore.
http://purl.obolibrary.org/obo/SCDO_1000211	Dominant Sickle Cell Disease	http://purl.obolibrary.org/obo/NCIT_C95534	Hemoglobin Trait		Clinical sickle cell disease in the heterozygous state due to an additional mutation on the same allele as the beta S mutation.
http://purl.obolibrary.org/obo/SCDO_1000215	Structural and Quantitative Hemoglobinopathy	http://purl.obolibrary.org/obo/SCDO_0000552	Hemoglobinopathy		A hemoglobinopathy involving the presence of structurally abnormal hemoglobins and defects in the quantity of hemoglobins synthesised.
http://purl.obolibrary.org/obo/SCDO_1000221	Alpha Thalassemia Silent Genotype	http://purl.obolibrary.org/obo/EUPATH_0000034	Alpha Thalassemia Genotype		A genotype whereby one of the four alpha-globin genes is faulty, either as a result of a single nucleotide variant (SNP) or of a deletion.
http://purl.obolibrary.org/obo/SCDO_1000224	Easy Bruisability	http://purl.obolibrary.org/obo/HP_0002597	Abnormality of the Vasculature		Increased susceptibility to bruising.
http://purl.obolibrary.org/obo/SCDO_1000225	Hemoglobin Genotype AC	http://purl.obolibrary.org/obo/SCDO_0004061	Genotype		A genotype whereby one HBB allele produces hemoglobin beta chains for normal adult hemoglobin and the other produces the abnormal hemoglobin beta chains for hemoglobin C. Individuals with this genotype are known to be carriers of the hemoglobin C trait.
http://purl.obolibrary.org/obo/SCDO_1000226	Hemoglobin Genotype AD	http://purl.obolibrary.org/obo/SCDO_0004061	Genotype		A genotype whereby one HBB allele produces hemoglobin beta chains for normal adult hemoglobin and the other produces the abnormal hemoglobin beta chains for hemoglobin D. Individuals with this genotype are known to be carriers of the hemoglobin D trait.
http://purl.obolibrary.org/obo/SCDO_1000227	Hemoglobin Genotype AE	http://purl.obolibrary.org/obo/SCDO_0004061	Genotype		A genotype whereby one HBB allele produces hemoglobin beta chains for normal adult hemoglobin and the other produces the abnormal hemoglobin beta chains for hemoglobin E. Individuals with this genotype are known to be carriers of the hemoglobin E trait.
http://purl.obolibrary.org/obo/SCDO_1000229	Hemoglobin Genotype EE	http://purl.obolibrary.org/obo/SCDO_0004061	Genotype		The homozygous genotype that involves a substitution of glutamic acid for a lysine at position 26 of beta-globin chains (hemoglobin E mutation) produced by both beta-globin gene (HBB) alleles.
http://purl.obolibrary.org/obo/SCDO_1000230	Hemoglobin Genotype DD	http://purl.obolibrary.org/obo/SCDO_0004061	Genotype		The homozygous genotype that involves a hemoglobin D mutation in both beta-globin gene (HBB) alleles.
http://purl.obolibrary.org/obo/SCDO_1000231	Hemoglobin Genotype O-Arab	http://purl.obolibrary.org/obo/SCDO_0004061	Genotype		The homozygous genotype that involves a substitution of glutamic acid for a lysine at position 121 of beta-globin chains (hemoglobin O-Arab mutation) produced by both beta-globin gene (HBB) alleles.
http://purl.obolibrary.org/obo/SCDO_1000232	Hemoglobin Genotype CC	http://purl.obolibrary.org/obo/SCDO_0004061	Genotype		The homozygous genotype that involves a substitution of glutamic acid for a lysine at position 6 of beta-globin chains (hemoglobin C mutation) produced by both beta-globin gene (HBB) alleles.
http://purl.obolibrary.org/obo/SCDO_1000233	Hemoglobin Genotype M	http://purl.obolibrary.org/obo/SCDO_0004061	Genotype		The presence of an amino acid substitution in either an alpha-, beta-, or gamma-globin chain such that its proximity to the heme iron in the hemoglobin molecule results in facilitated oxidation of the hemoglobin to yield excess methemoglobin. This can occur in either one or both alleles of the effected gene.
http://purl.obolibrary.org/obo/SCDO_1000235	Hereditary Persistence of Fetal Hemoglobin Genotype	http://purl.obolibrary.org/obo/SCDO_0004061	Genotype		Either homozygosity or heterozygosity for the HPFH1 mutation, a 106-KB deletion in the beta globin gene cluster.
http://purl.obolibrary.org/obo/SCDO_1000236	Hemoglobin Lepore Boston Genotype	http://purl.obolibrary.org/obo/SCDO_0007624	Beta Thalassemia Genotype		The homozygous genotype for Hemoglobin Lepore Boston that involves a crossover between both sets of delta (HBD) and beta globin (HBB) gene loci during meiosis.
http://purl.obolibrary.org/obo/SCDO_1000237	Hemoglobin C-Harlem Trait	http://purl.obolibrary.org/obo/NCIT_C95534	Hemoglobin Trait		The inheritance of one normal HBB gene along with an abnormal HBB gene that contains two amino acid substitutions, namely Glu6Val (HbS) and Asp73Asn.
http://purl.obolibrary.org/obo/SCDO_1000238	CYB5R3 Mutation	http://purl.obolibrary.org/obo/IDOMAL_50000026	Mutation		A mutation in the NADH-Cytochrome b5 Reductase 3 gene, CYB5R3, that contributes to the presence of methemoglobinemia (type I or II).
http://purl.obolibrary.org/obo/SCDO_1000239	Heterozygous Deletion of HBA1 or HBA2	http://purl.obolibrary.org/obo/SCDO_0001386	Alpha-Globin Locus Deletion		Deletion of one alpha-globin gene, either an HBA1 or HBA2 gene, which results in Alpha Thalassemia Silent (the person with the mutation is a silent carrier).
http://purl.obolibrary.org/obo/SCDO_1000240	Reduced or Absent Hemoglobin A	http://purl.obolibrary.org/obo/SCDO_1000061	Altered Level of Normal Hemoglobin in SCD		Either a decrease in the proportion of hemoglobin A to below 96-98% of all hemoglobin, or a complete lack of hemoglobin A production.
http://purl.obolibrary.org/obo/SCDO_1000241	Absent Hemoglobin A	http://purl.obolibrary.org/obo/HP_0020061	Abnormal Hemoglobin Concentration		A lack of production of normal adult hemoglobin.
http://purl.obolibrary.org/obo/SCDO_1000243	Autosomal Recessive Compound Heterozygous	http://purl.obolibrary.org/obo/HP_0000007	Autosomal Recessive		A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals that are compound heterozygotes (whereby each copy of a gene has a distinct mutant allele).
http://purl.obolibrary.org/obo/SCDO_1000244	Sickle Cell Trait with a Severe Pyruvate Kinase Deficiency	http://purl.obolibrary.org/obo/SCDO_1000211	Dominant Sickle Cell Disease		A sickle cell disease phenotype in which an individual heterozygous for hemoglobin S also has a severe pyruvate kinase deficiency, which lowers the hemoglobin oxygen affinity, resulting in hemoglobin S polymerization and sickling.
http://purl.obolibrary.org/obo/SCDO_1000247	L-Glutamine Oral Powder	http://purl.obolibrary.org/obo/CHEBI_23888	Drug		A powder form of the optically active form of glutamine having L-configuration; to be administered orally.
http://purl.obolibrary.org/obo/SCDO_1000250	deprecated Abnormal Molecular Function	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		A phenotype in which a specific molecular function is abnormal.
http://purl.obolibrary.org/obo/SCDO_1000251	Increased Red Cell Osmotic Fragility	http://purl.obolibrary.org/obo/HP_0020054	Abnormal Erythrocyte Physiology		An increase in red blood cell sensitivity to change in osmotic pressure. More specifically, the degree or proportion of hemolysis that occurs when a sample of red blood cells are subjected to osmotic stress by being placed in a hypotonic solution.
http://purl.obolibrary.org/obo/SCDO_1000253	Abnormal Biological Process	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		A situation in which a specific biological process within an organism is abnormal.
http://purl.obolibrary.org/obo/SCDO_1000254	Polymerisation of Hemoglobin	http://purl.obolibrary.org/obo/SCDO_1000253	Abnormal Biological Process		When deoxygenated, malfunctioning or mutated hemoglobins clump together and form a long polymer.
http://purl.obolibrary.org/obo/SCDO_1000255	Guidelines on Red Cell Transfusion in Sickle Cell Disease - Part II: Indications for Transfusion	http://purl.obolibrary.org/obo/SCDO_1000143	Disease Management Guideline		Guidelines that examine current available evidence on indications for transfusion in sickle cell disease.
http://purl.obolibrary.org/obo/SCDO_1000256	Sickle Cell Acute Painful Episode - Management of an Acute Painful Sickle Cell Episode in Hospital	http://purl.obolibrary.org/obo/SCDO_1000143	Disease Management Guideline		This guideline addresses the management of an acute painful sickle cell episode in patients presenting to hospital until discharge. This includes the use of pharmacological and non-pharmacological interventions, identifying the signs and symptoms of acute complications, skills and settings for managing an acute painful episode, and the information and support needs of patients.
http://purl.obolibrary.org/obo/SCDO_1000257	Three Tips About Sickle Cell Disease Every Emergency Provider Needs to Know	http://purl.obolibrary.org/obo/SCDO_1000143	Disease Management Guideline		A factsheet that shares steps to improve care in emergency departments (ED) of hospitals and clinics for people with sickle cell disease (SCD). It was created to help improve healthcare in the ED for patients with SCD.
http://purl.obolibrary.org/obo/SCDO_1000258	Practice Guidelines: Management of Pain in Sickle Cell Disease	http://purl.obolibrary.org/obo/SCDO_1000143	Disease Management Guideline		A comprehensive guideline to aid physicians and other health care professionals in the management of patients with acute and chronic pain associated with sickle cell disease (SCD). The guideline covers the following information: an overview of the disease, the types and characteristics of pain associated with the disease, recommendations for pain assessment, methods for treatment of pain and a discussion of pain in the various developmental stages. It also includes discussions of pain assessment instruments.
http://purl.obolibrary.org/obo/SCDO_1000259	Unusual Hemoglobin	http://purl.obolibrary.org/obo/SCDO_0006921	Hemoglobin Variant		A hemoglobin that shows characteristics of an abnormal hemoglobin, but its inheritance does not accompany any disability.
http://purl.obolibrary.org/obo/SCDO_1000260	Symptom Induced by Strenuous Exercise	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		Any feeling of illness or physical or mental change that results from strenuous exercise.
http://purl.obolibrary.org/obo/SCDO_1000261	Avitaminosis	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		A condition due to a deficiency of one or more essential vitamins. (Dorland, 27th ed)
http://purl.obolibrary.org/obo/SCDO_1000268	Abnormality of the Musculature	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		Abnormality originating in one or more muscles of the set of muscles in the body.
http://purl.obolibrary.org/obo/SCDO_1000276	Abnormal Hemoglobin Level in SCD	http://purl.obolibrary.org/obo/SCDO_1000060	SCD Molecular Phenotype		An abnormal level of hemoglobin that occurs in one or more forms of Sickle Cell Disease (SCD).
http://purl.obolibrary.org/obo/SCDO_1000280	Transfusion Hemochromatosis	http://purl.obolibrary.org/obo/SCDO_1000281	Secondary Hemochromatosis		Hemochromatosis that results from repeated blood transfusions.
http://purl.obolibrary.org/obo/SCDO_1000281	Secondary Hemochromatosis	http://purl.obolibrary.org/obo/NCIT_C78393	Iron Overload		An acquired metabolic disorder characterized by iron accumulation in the tissues.
http://purl.obolibrary.org/obo/SCDO_1000289	Hemoglobin D-Punjab Present	http://purl.obolibrary.org/obo/HP_0020061	Abnormal Hemoglobin Concentration		When the abnormal hemoglobin, hemoglobin D-Punjab (Hb D-Punjab), has been detected in a blood sample.
http://purl.obolibrary.org/obo/SCDO_1000290	Hemoglobin G-Philadelphia Present	http://purl.obolibrary.org/obo/HP_0020061	Abnormal Hemoglobin Concentration		When the abnormal hemoglobin, hemoglobin G-Philadelphia (Hb G-Philadelphia), has been detected in a blood sample.
http://purl.obolibrary.org/obo/SCDO_1000291	Hemoglobin O-Arab Present	http://purl.obolibrary.org/obo/HP_0020061	Abnormal Hemoglobin Concentration		When the abnormal hemoglobin, hemoglobin O-Arab (Hb O-Arab), has been detected in a blood sample.
http://purl.obolibrary.org/obo/SCDO_1000292	Normal Hemoglobin F Level	http://purl.obolibrary.org/obo/SCDO_1000783	Normal Hemoglobin Concentration		When the level of hemoglobin F detected in a sample of blood falls in the normal range for HbF.
http://purl.obolibrary.org/obo/SCDO_1000295	Quality of Life Assessment Score	http://purl.obolibrary.org/obo/SCDO_1000318	Diagnostic Instrument Measurement		The score obtained from a quality of life-related diagnostic instrument.
http://purl.obolibrary.org/obo/SCDO_1000296	ASCQ-Me Score	http://purl.obolibrary.org/obo/SCDO_1000295	Quality of Life Assessment Score		The score obtained from the Adult Sickle Cell Quality-of-Life Measurement Information System (ASCQ-Me) diagnostic instrument.
http://purl.obolibrary.org/obo/SCDO_1000298	Hepatitis B Virus Surface Antigen Test	http://purl.obolibrary.org/obo/SCDO_0000616	Immunochemical Assay		A deteremination of the presence of hepatitis B virus surface antigen.
http://purl.obolibrary.org/obo/SCDO_1000299	Hepatitis B Surface Antibody Test	http://purl.obolibrary.org/obo/SCDO_1000302	Hepatitis B Virus Antibody Test		The determination of the surface antibody reaction of a sample to the Hepatitis B virus.
http://purl.obolibrary.org/obo/SCDO_1000300	Hepatitis B Core Antibody Test	http://purl.obolibrary.org/obo/SCDO_1000302	Hepatitis B Virus Antibody Test		The determination of the amount of Hepatitis B virus core antibody present in a sample.
http://purl.obolibrary.org/obo/SCDO_1000301	Hepatitis B Blood Panel	http://purl.obolibrary.org/obo/SCDO_0000616	Immunochemical Assay		A set of three blood tests (Hepatitis B Core Antibody Test, Hepatitis B Surface Antibody Test, and Hepatitis B Virus Surface Antigen Test) needed to fully understand whether a person is infected with Hepatitis B or not.
http://purl.obolibrary.org/obo/SCDO_1000302	Hepatitis B Virus Antibody Test	http://purl.obolibrary.org/obo/SCDO_0000616	Immunochemical Assay		The determination of the amount of hepatitis B virus antibody present in a sample.
http://purl.obolibrary.org/obo/SCDO_1000303	Hepatitis B Core IgG Antibody Test	http://purl.obolibrary.org/obo/SCDO_1000300	Hepatitis B Core Antibody Test		The determination of the amount of hepatitis B virus core IgG antibody in a biological specimen.
http://purl.obolibrary.org/obo/SCDO_1000304	Hepatitis B Core IgM Antibody Test	http://purl.obolibrary.org/obo/SCDO_1000300	Hepatitis B Core Antibody Test		The determination of the amount of Hepatitis B virus core IgM antibody present in a sample.
http://purl.obolibrary.org/obo/SCDO_1000305	Pulse Oximetry (Exercise)	http://purl.obolibrary.org/obo/NCIT_C38085	Pulse Oximetry		Exercise testing for evaluation of hypoxemia and/or desaturation that occurs on exertion.
http://purl.obolibrary.org/obo/SCDO_1000306	Hepatitis C Virus Antigen Test	http://purl.obolibrary.org/obo/SCDO_0000616	Immunochemical Assay		The determination of the amount of hepatitis C virus antigen present in a sample.
http://purl.obolibrary.org/obo/SCDO_1000307	Hepatitis C Antibody Test	http://purl.obolibrary.org/obo/SCDO_0000616	Immunochemical Assay		A determination of the presence of the hepatitis C virus antibody in a biological specimen.
http://purl.obolibrary.org/obo/SCDO_1000308	Hepatitis C Virus Core Antigen Test	http://purl.obolibrary.org/obo/SCDO_1000306	Hepatitis C Virus Antigen Test		The determination of the amount of hepatitis C virus core antigen in a biological sample.
http://purl.obolibrary.org/obo/SCDO_1000309	Hepatitis C Surface Antibody Test	http://purl.obolibrary.org/obo/SCDO_1000307	Hepatitis C Antibody Test		The determination of the surface antibody reaction of a sample to the Hepatitis C virus.
http://purl.obolibrary.org/obo/SCDO_1000310	Cystatin C Blood Test	http://purl.obolibrary.org/obo/SCDO_0000676	Kidney Function Test		The determination of the amount of cystatin C present in a sample.
http://purl.obolibrary.org/obo/SCDO_1000313	Diagnostic Device Visual Output	http://purl.obolibrary.org/obo/SCDO_0000379	Diagnostics		The visual output that a specific diagnostic device produces.
http://purl.obolibrary.org/obo/SCDO_1000314	Red Blood Cell Microparticles Assay	http://purl.obolibrary.org/obo/SCDO_0000133	Blood Test		A bioassay to measure levels of red blood cell microparticles.
http://purl.obolibrary.org/obo/SCDO_1000316	Blood Flow Test	http://purl.obolibrary.org/obo/SCDO_0000902	Physiological Assay		A technique used to measure velocity and amount of blood flow and circulation in the living system.
http://purl.obolibrary.org/obo/SCDO_1000317	Heart Measurement	http://purl.obolibrary.org/obo/CMO_0000001	Cardiovascular Measurement		Any value resulting from the quantification of a morphological or physiological parameter pertaining to the heart.
http://purl.obolibrary.org/obo/SCDO_1000318	Diagnostic Instrument Measurement	http://purl.obolibrary.org/obo/SCDO_0000728	Diagnostic Measurement		An information entity, used in the diagnosis of medical conditions, that is a recording of the output of a diagnostic instrument.
http://purl.obolibrary.org/obo/SCDO_1000319	Cigarette Smoking Status Diagnostic Instrument	http://purl.obolibrary.org/obo/SCDO_1000033	Diagnostic Instrument		Questions asking the respondent about smoking status in his or her entire life.
http://purl.obolibrary.org/obo/SCDO_1000321	Cigarette Smoking Status Diagnostic Instrument - Adolescent	http://purl.obolibrary.org/obo/SCDO_1000319	Cigarette Smoking Status Diagnostic Instrument		Questions asking an adolescentt respondent about smoking status in his or her entire life.
http://purl.obolibrary.org/obo/SCDO_1000322	Never Smoker	http://purl.obolibrary.org/obo/SCDO_0000235	Cigarette Smoking Status		A person who has never smoked a cigarette, not even one or two puffs.
http://purl.obolibrary.org/obo/SCDO_1000323	Current Every-Day Smoker	http://purl.obolibrary.org/obo/SCDO_0000235	Cigarette Smoking Status		A person who was smoking on a daily basis at the time of the interview.
http://purl.obolibrary.org/obo/SCDO_1000324	Current Some-Day Smoker	http://purl.obolibrary.org/obo/SCDO_0000235	Cigarette Smoking Status		A person who had smoked a cigarette in the past, and was smoking on some days, but not daily, at the time of the interview.
http://purl.obolibrary.org/obo/SCDO_1000325	Former Smoker	http://purl.obolibrary.org/obo/SCDO_0000235	Cigarette Smoking Status		A person who was not smoking at the time of the interview but has smoked a cigarette in the past, even if just one or two puffs
http://purl.obolibrary.org/obo/SCDO_1000326	Ever-Smoker	http://purl.obolibrary.org/obo/SCDO_0000235	Cigarette Smoking Status		A person who has smoked a cigarette in the past, even if just one or two puffs, but was unable to or refused to answer when asked when the last time was that they smoked a cigarette, even one or two puffs.
http://purl.obolibrary.org/obo/SCDO_1000327	Past 30-Day Smoker	http://purl.obolibrary.org/obo/SCDO_0000235	Cigarette Smoking Status		A person who had smoked in the past 30 days at the time of the interview, but who had not smoked every day of the past 30 days.
http://purl.obolibrary.org/obo/SCDO_1000328	Past 30-Day Every-Day Smoker	http://purl.obolibrary.org/obo/SCDO_0000235	Cigarette Smoking Status		A person who had smoked every day of the past 30 days at the time of the interview.
http://purl.obolibrary.org/obo/SCDO_1000329	Alcohol - Lifetime Use Diagnostic Instrument	http://purl.obolibrary.org/obo/SCDO_1000474	Clinical or Research Assessment Data Element		Question asking the respondent if s/he has ever consumed any alcoholic beverage during his or her entire life.
http://purl.obolibrary.org/obo/SCDO_1000330	Epilepsy Screener - Adult	http://purl.obolibrary.org/obo/SCDO_0000440	Epilepsy Screener		A nine-item, interviewer-administered questionnaire to screen for the presence of epilepsy in adults.
http://purl.obolibrary.org/obo/SCDO_1000331	Epilepsy Screener - Child/Proxy	http://purl.obolibrary.org/obo/SCDO_0000440	Epilepsy Screener		A nine-item, interviewer-administered questionnaire to screen for the presence of epilepsy in family members, including children and those who are deceased.
http://purl.obolibrary.org/obo/SCDO_1000332	Executive Dysfunction	http://purl.obolibrary.org/obo/HP_0000708	Behavioural Abnormality		A disruption to the efficacy of the executive functions, which is a group of cognitive processes that regulate, control, and manage other cognitive processes.
http://purl.obolibrary.org/obo/SCDO_1000333	Global Mental Status Screener - Child	http://purl.obolibrary.org/obo/SCDO_0000455	Global Mental Status Screener		A series of 21 age-specific questionnaires and scoring sheets designed to screen a child's skills in five developmental areas: fine motor, gross motor, problem solving, communication, and personal-social. A child's scores for each area are compared to cut-off scores to determine a need for monitoring or further assessment.
http://purl.obolibrary.org/obo/SCDO_1000336	Frequency of Sickle Cell Pain Episodes	http://purl.obolibrary.org/obo/SCDO_1000318	Diagnostic Instrument Measurement		The frequency of acute pain episodes due to sickle cell disease (SCD).
http://purl.obolibrary.org/obo/SCDO_1000337	Substances - Lifetime Use Diagnostic Instrument	http://purl.obolibrary.org/obo/NCIT_C91105	Clinical or Research Assessment Questionnaire		Questions from the National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III) related to their lifetime use of illicit and prescribed substances.
http://purl.obolibrary.org/obo/SCDO_1000338	Sleep Disorders Screener - Children	http://purl.obolibrary.org/obo/SCDO_1000348	Sleep Disorders Screener		A 26-item, self-administered scale completed by the parent that assesses the child's sleep behaviors in the past 6 months. The scale includes six subscales: disorders of initiating and maintaining sleep (items 1, 2, 3, 4, 5, 10, 11); sleep breathing disorders (items 13, 14, 15); disorders of arousal (items 17, 20, 21); sleep-wake transition disorders (items 6, 7, 8, 12, 18, 19); disorders of excessive somnolence (items 22, 23, 24, 25, 26); and sleep hyperhidrosis (score of the items 9, 16). Each item is rated on a 5-point, Likert-type scale (1 = Never; 5 = Always [daily]). Scores from individual items of each subscale are added together to give a subscale score, with higher scores indicating greater symptoms. Scores from the individual subscales can be added together to give a total score.
http://purl.obolibrary.org/obo/SCDO_1000339	History of Head Trauma	http://purl.obolibrary.org/obo/NCIT_C18772	Personal Medical History		A record of an individual's background in regard to head trauma.
http://purl.obolibrary.org/obo/SCDO_1000340	History of Stroke	http://purl.obolibrary.org/obo/NCIT_C18772	Personal Medical History		A record of an individual's history of stroke(s) and associated symptoms such as slurred speech, double vision, loss of vision, and paralysis.
http://purl.obolibrary.org/obo/SCDO_1000341	History of Kidney Failure	http://purl.obolibrary.org/obo/NCIT_C18772	Personal Medical History		A record of an individual's history of kidney failure.
http://purl.obolibrary.org/obo/SCDO_1000343	History of Type 1 and Type 2 Diabetes	http://purl.obolibrary.org/obo/NCIT_C18772	Personal Medical History		A record of an individual's history of type 1 and type 2 diabetes.
http://purl.obolibrary.org/obo/SCDO_1000344	Reproductive History Diagnostic Instrument - Male	http://purl.obolibrary.org/obo/SCDO_0000987	Reproductive History Diagnostic Instrument		A questionnaire to assess males' pregnancy history.
http://purl.obolibrary.org/obo/SCDO_1000345	Reproductive History Diagnostic Instrument - Female	http://purl.obolibrary.org/obo/SCDO_0000987	Reproductive History Diagnostic Instrument		A questionnaire to assess females' pregnancy history.
http://purl.obolibrary.org/obo/SCDO_1000348	Sleep Disorders Screener	http://purl.obolibrary.org/obo/NCIT_C91105	Clinical or Research Assessment Questionnaire		A questionnaire to assess sleep disorders, a broad group of disorders that can be caused by endogenous disturbances in the sleep-wake or timing cycles (American Psychiatric Association, 2000).
http://purl.obolibrary.org/obo/SCDO_1000350	Heart Valve Function Test	http://purl.obolibrary.org/obo/SCDO_0000500	Heart Function Test		A test to assess the structure and function of the heart valves.
http://purl.obolibrary.org/obo/SCDO_1000352	Spirometry - Adult	http://purl.obolibrary.org/obo/NCIT_C85397	Spirometry		Measurement of the breathing capacity of an adult's lung by means of a spirometer.
http://purl.obolibrary.org/obo/SCDO_1000353	Spirometry - Child	http://purl.obolibrary.org/obo/NCIT_C85397	Spirometry		Measurement of the breathing capacity of a child's lung by means of a spirometer.
http://purl.obolibrary.org/obo/SCDO_1000354	Health Risk Behavior	http://purl.obolibrary.org/obo/SCDO_0000487	Health Behaviour		Pattern of behavior which predisposes certain individuals to increased risk for contracting disease or sustaining personal injury. These behaviors may cluster into a risky lifestyle.
http://purl.obolibrary.org/obo/SCDO_1000355	Health Facility Environment	http://purl.obolibrary.org/obo/ExO_0000048	Built Environment		Physical surroundings or conditions of a hospital or other health facility and influence of these factors on patients and staff.
http://purl.obolibrary.org/obo/SCDO_1000356	Altitude	http://purl.obolibrary.org/obo/SCDO_0000897	Physical Environment		Height above sea level or above the earth's surface.
http://purl.obolibrary.org/obo/SCDO_1000357	Self Reported Educational Attainment	http://purl.obolibrary.org/obo/SCDO_0000305	Current Educational Attainment		A measure of educational progress reported using a questionnaire based approach, often used as a proxy for cognitive performance as the two are correlated.
http://purl.obolibrary.org/obo/SCDO_1000360	Globin Gene	http://purl.obolibrary.org/obo/NCIT_C16612	Gene		A gene that encodes one of the globin family proteins, which are globular heme-containing proteins and include androglobin, cryoglobin, hemoglobin subunits, myoglobin and neuroglobin.
http://purl.obolibrary.org/obo/SCDO_1000361	Alpha-Globin Gene	http://purl.obolibrary.org/obo/SCDO_1000360	Globin Gene		A gene that provides instructions for making a protein called alpha-globin.
http://purl.obolibrary.org/obo/SCDO_1000362	Beta-Globin Gene	http://purl.obolibrary.org/obo/SCDO_1000360	Globin Gene		A gene located in the beta-globin locus (or gene cluster) on chromosome 11.
http://purl.obolibrary.org/obo/SCDO_1000363	Hemoglobin Subunit Zeta	http://purl.obolibrary.org/obo/SCDO_1000105	Alpha-Globin Family Members		A member of the alpha-globin family. In humans, it is encoded in the alpha-globin gene cluster or locus, located on chromosome 16. Two hemoglobin subunit zeta chains combine with two hemoglobin subunit epsilon chains to form the embryonic Hemoglobin Gower 1.
http://purl.obolibrary.org/obo/SCDO_1000364	Hemoglobin A2	http://purl.obolibrary.org/obo/SCDO_0006835	Normal Hemoglobin		An adult hemoglobin component normally present in hemolysates from human erythrocytes in concentrations of about 3%. The hemoglobin is composed of two alpha chains and two delta chains. The percentage of HbA2 varies in some hematologic disorders, but is about double in beta-thalassemia.
http://purl.obolibrary.org/obo/SCDO_1000366	Delta Beta Thalassemia Mutation	http://purl.obolibrary.org/obo/SCDO_0009731	Beta Thalassemia Mutation		A mutation that contributes to decreased or absent synthesis of the delta- and beta-globin chains with a compensatory increase in expression of fetal gamma-chain synthesis.
http://purl.obolibrary.org/obo/SCDO_1000371	Prenatal Maternal Abnormality	http://purl.obolibrary.org/obo/HP_0001197	Abnormality of Prenatal Development or Birth		A health abnormality in a woman during pregnancy.
http://purl.obolibrary.org/obo/SCDO_1000376	Osteonecrosis of the Humeral Head	http://purl.obolibrary.org/obo/HP_0010885	Osteonecrosis		In situ death of bone within the humeral head due to disruption of blood supply.
http://purl.obolibrary.org/obo/SCDO_1000379	Culturally Competent Care	http://purl.obolibrary.org/obo/SCDO_0000246	Clinical Competence		Health care services that are respectful of and responsive to the health beliefs, practices and cultural and linguistic needs of diverse patients. The provider and the patient each bring their individual learned patterns of language and culture to the health care experience which must be transcended to achieve equal access and quality health care.
http://purl.obolibrary.org/obo/SCDO_1000392	Sp1 Transcription Factor	http://purl.obolibrary.org/obo/NCIT_C26548	Gene Product		Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.
http://purl.obolibrary.org/obo/SCDO_1000394	Gene Component	http://purl.obolibrary.org/obo/SCDO_0005722	Genetic Structure		A gene component is a component of a gene.
http://purl.obolibrary.org/obo/SCDO_1000395	Gene Regulatory Component	http://purl.obolibrary.org/obo/SCDO_1000394	Gene Component		A gene regulatory component is a gene component that exerts a regulatory function.
http://purl.obolibrary.org/obo/SCDO_1000396	Gene Enhancer	http://purl.obolibrary.org/obo/SCDO_1000395	Gene Regulatory Component		A gene enhancer is a short region of DNA that can be bound with proteins to enhance transcription levels of genes in a gene cluster.
http://purl.obolibrary.org/obo/SCDO_1000397	Gene Promoter	http://purl.obolibrary.org/obo/SCDO_1000395	Gene Regulatory Component		A gene promoter is a region of DNA that initiates transcription of a particular gene.
http://purl.obolibrary.org/obo/SCDO_1000401	Data Descriptor	http://purl.obolibrary.org/obo/SCDO_0006339	Research		A characteristic that further describes the nature of data.
http://purl.obolibrary.org/obo/SCDO_1000402	Journal Article	http://purl.obolibrary.org/obo/SCDO_0300003	Publication Formats		The predominant publication type for articles and other items indexed for NLM databases.
http://purl.obolibrary.org/obo/SCDO_1000406	Data Sharing Descriptor	http://purl.obolibrary.org/obo/SCDO_0006339	Research		A characteristic or directive that further describes the nature of data sharing.
http://purl.obolibrary.org/obo/SCDO_1000421	Participant Feedback Policy	http://purl.obolibrary.org/obo/SCDO_1000424	Study Policy		The standard method of providing feedback to study participants regarding their information (data, biological samples, genetic material) that has been shared.
http://purl.obolibrary.org/obo/SCDO_1000422	Basic Element of a Consent Form	http://purl.obolibrary.org/obo/SCDO_0007597	Descriptor of Consent		An element or information entity that is required to be provided in consent forms.
http://purl.obolibrary.org/obo/SCDO_1000423	Participant Withdrawal Policy	http://purl.obolibrary.org/obo/SCDO_1000424	Study Policy		The policy regarding participants' right to withdraw their participation in a study.
http://purl.obolibrary.org/obo/SCDO_1000424	Study Policy	http://purl.obolibrary.org/obo/SCDO_0300005	Research Characteristics		A course or principle of action adopted or proposed by a study.
http://purl.obolibrary.org/obo/SCDO_1000425	Study Focus Statement	http://purl.obolibrary.org/obo/SCDO_1000422	Basic Element of a Consent Form		A statement of what the key investigational purpose of the study is.
http://purl.obolibrary.org/obo/SCDO_1000426	Communicable Disease - Report by Law Statement	http://purl.obolibrary.org/obo/SCDO_1000422	Basic Element of a Consent Form		A statement about how the researcher is obligated by law to report if the participant is found to have a communicable disease.
http://purl.obolibrary.org/obo/SCDO_1000429	Medical Ethics	http://purl.obolibrary.org/obo/SCDO_0006706	Bioethics		The principles of professional conduct concerning the rights and duties of the physician, relations with patients and fellow practitioners, as well as actions of the physician in patient care and interpersonal relations with patient families.
http://purl.obolibrary.org/obo/SCDO_1000430	Ethics Related Concept	http://purl.obolibrary.org/obo/SCDO_0006339	Research		Concepts related to ethics, excluding types of ethics.
http://purl.obolibrary.org/obo/SCDO_1000431	Intestinal Fatty-Acid Binding Protein	http://purl.obolibrary.org/obo/NCIT_C26548	Gene Product		A protein expressed in enterocytes of the small intestine and released into the systemic circulation when there is intestinal damage. This protein plays a role in binding to saturated long-chain fatty acids with a high affinity and to unsaturated long-chain fatty acids with less affinity.
http://purl.obolibrary.org/obo/SCDO_1000432	Serum iFABP Level	http://purl.obolibrary.org/obo/CMO_0000023	Blood Chemistry Measurement		The level of intestinal fatty-acid binding protein in the systemic circulation (serum).
http://purl.obolibrary.org/obo/SCDO_1000433	Intestinal Injury	http://purl.obolibrary.org/obo/HP_0025031	Abnormality of the Digestive System		Damage inflicted on the intestine.
http://purl.obolibrary.org/obo/SCDO_1000436	Hypoxia-Reperfusion Injury	http://purl.obolibrary.org/obo/NCIT_C3671	Injury		Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (reperfusion), including swelling; hemorrhage; necrosis; and damage from free radicals. The most common instance is myocardial reperfusion injury.
http://purl.obolibrary.org/obo/SCDO_1000439	Elevated Serum iFABP Level	http://purl.obolibrary.org/obo/HP_0010876	Abnormal Circulating Protein Level		An increased circulating blood concentration of the intestinal fatty-acid binding protein.
http://purl.obolibrary.org/obo/SCDO_1000444	Serum L-Selectin Level	http://purl.obolibrary.org/obo/CMO_0000023	Blood Chemistry Measurement		The level of L-selectin in the systemic circulation (serum).
http://purl.obolibrary.org/obo/SCDO_1000445	Aged Neutrophil Count	http://purl.obolibrary.org/obo/CMO_0000030	Blood Neutrophil Count		The number of aged neutrophils in a specified volume of blood, usually 1 cubic millimeter.
http://purl.obolibrary.org/obo/SCDO_1000448	Adjunct Analgesic Agent	http://purl.obolibrary.org/obo/SCDO_0001133	Symptomatic Therapeutics		A medication that is typically used for indications other than pain control but provides control of pain in some painful diseases.
http://purl.obolibrary.org/obo/SCDO_1000449	Low-Dose Ketamine Infusion	http://purl.obolibrary.org/obo/SCDO_1000448	Adjunct Analgesic Agent		An infusion of ketamine at a low dose (up to 5 µg/kg/min).
http://purl.obolibrary.org/obo/SCDO_1000452	Cancer Pain	http://purl.obolibrary.org/obo/SCDO_0000851	Pain		Pain that may be caused by or related to cellular, tissue, and systemic changes that occur during neoplasm growth, tissue invasion, and metastasis.
http://purl.obolibrary.org/obo/SCDO_1000455	Calculated Current Age (Years)	http://purl.obolibrary.org/obo/SCDO_1000527	Calculated Current Age		The current age of a patient, calculated using the current date and the patient's date of birth and provided in years.
http://purl.obolibrary.org/obo/SCDO_1000457	Temporal Consent Concept	http://purl.obolibrary.org/obo/NCIT_C25460	Consent		A type of consent that includes an aspect of timing (i.e. an indication of when consent was acquired).
http://purl.obolibrary.org/obo/SCDO_1000458	Prospective Consent	http://purl.obolibrary.org/obo/SCDO_1000457	Temporal Consent Concept		Consent given prior to enrollment.
http://purl.obolibrary.org/obo/SCDO_1000459	Deferred Consent	http://purl.obolibrary.org/obo/SCDO_1000457	Temporal Consent Concept		Consent that is taken later after enrollment into study especially in emergency situations.
http://purl.obolibrary.org/obo/SCDO_1000460	Prospective Informed Consent	http://purl.obolibrary.org/obo/SCDO_1000458	Prospective Consent		Informed consent given prior to enrollment.
http://purl.obolibrary.org/obo/SCDO_1000461	Waived Consent	http://purl.obolibrary.org/obo/NCIT_C25460	Consent		Consent obtained at a population level through public/community engagement where individual consenting is not feasible. This is normally done for low risk studies and/or in case of emergencies.
http://purl.obolibrary.org/obo/SCDO_1000462	Research Ethics Committee Decision	http://purl.obolibrary.org/obo/SCDO_1000430	Ethics Related Concept		A decision made by a research ethics committee.
http://purl.obolibrary.org/obo/SCDO_1000463	Approval of Ethics	http://purl.obolibrary.org/obo/SCDO_1000462	Research Ethics Committee Decision		When a research ethics committee approves a study's application for approval of their proposed research.
http://purl.obolibrary.org/obo/SCDO_1000464	Disapproval of Ethics	http://purl.obolibrary.org/obo/SCDO_1000462	Research Ethics Committee Decision		When a research ethics committee declines a study's application for approval of their proposed research.
http://purl.obolibrary.org/obo/SCDO_1000465	Mode of Providing Consent	http://purl.obolibrary.org/obo/SCDO_0007597	Descriptor of Consent		A method in which a patient or their legal representative provides consent.
http://purl.obolibrary.org/obo/SCDO_1000466	Written Consent	http://purl.obolibrary.org/obo/SCDO_1000465	Mode of Providing Consent		When the participant or a legal representative or family member provides consent by filling out and/or signing a written form.
http://purl.obolibrary.org/obo/SCDO_1000467	Verbal Consent	http://purl.obolibrary.org/obo/SCDO_1000465	Mode of Providing Consent		When the participant communicates consent orally rather than by filling out and signing a written form. Normally a witness is present when verbal consent is given.
http://purl.obolibrary.org/obo/SCDO_1000470	SickleInAfrica Participant Number	http://purl.obolibrary.org/obo/NCIT_C69256	Subject Unique Identifier		A unique identifier assigned to a study participant's data when it is registered in the SickleInAfrica data registry.
http://purl.obolibrary.org/obo/SCDO_1000471	Country of Data Collection	http://purl.obolibrary.org/obo/SCDO_1000401	Data Descriptor		The name of the country where the sample or data was collected.
http://purl.obolibrary.org/obo/SCDO_1000472	Data Standards	http://purl.obolibrary.org/obo/SCDO_0001000	SCDO		The rules by which data are described and recorded.
http://purl.obolibrary.org/obo/SCDO_1000474	Clinical or Research Assessment Data Element	http://purl.obolibrary.org/obo/SCDO_1000472	Data Standards		A data element used to capture or facilitate the capture of data in a clinical or research assessment.
http://purl.obolibrary.org/obo/SCDO_1000475	Clinical or Research Assessment Question Type	http://purl.obolibrary.org/obo/SCDO_1000472	Data Standards		A type of question pertaining to a clinical or research assessment data element.
http://purl.obolibrary.org/obo/SCDO_1000490	Consent Status	http://purl.obolibrary.org/obo/SCDO_0007597	Descriptor of Consent		The situation, with regard to obtaining consent from a respondent, at a particular stage during a process.
http://purl.obolibrary.org/obo/SCDO_1000492	Close-Ended Question	http://purl.obolibrary.org/obo/SCDO_1000475	Clinical or Research Assessment Question Type		A question that provides the respondent with specific answer options to choose from.
http://purl.obolibrary.org/obo/SCDO_1000493	Open-Ended Question	http://purl.obolibrary.org/obo/SCDO_1000475	Clinical or Research Assessment Question Type		A question that allows the respondent to give their own answer instead of selecting an answer from answer options.
http://purl.obolibrary.org/obo/SCDO_1000494	Dichotomous Question	http://purl.obolibrary.org/obo/SCDO_1000492	Close-Ended Question		A close-ended question that provides two possible answers.
http://purl.obolibrary.org/obo/SCDO_1000495	Multiple Choice Multiple Selection Question	http://purl.obolibrary.org/obo/SCDO_1000492	Close-Ended Question		A close-ended question that provides multiple answers for respondents to select from and allows for the selection of multiple options.
http://purl.obolibrary.org/obo/SCDO_1000496	Multiple Choice Single Selection Question	http://purl.obolibrary.org/obo/SCDO_1000492	Close-Ended Question		A close-ended question that provides multiple answers for respondents to select from but allows for the selection of only one option.
http://purl.obolibrary.org/obo/SCDO_1000497	True-False Question	http://purl.obolibrary.org/obo/SCDO_1000494	Dichotomous Question		A dichotomous question that has answer options "true" and "false".
http://purl.obolibrary.org/obo/SCDO_1000498	Yes-No Question	http://purl.obolibrary.org/obo/SCDO_1000494	Dichotomous Question		A dichotomous question that has answer options "yes" and "no".
http://purl.obolibrary.org/obo/SCDO_1000501	Open-Ended Question - Restricted	http://purl.obolibrary.org/obo/SCDO_1000493	Open-Ended Question		A open ended question that restricts the nature of the text answer that can be provided by the respondent.
http://purl.obolibrary.org/obo/SCDO_1000502	Open-Ended Question - Free Text	http://purl.obolibrary.org/obo/SCDO_1000493	Open-Ended Question		A open ended question that allows the respondent to respond in free text, without any restrictions on the nature of the text answer provided.
http://purl.obolibrary.org/obo/SCDO_1000508	SickleInAfrica Data Element	http://purl.obolibrary.org/obo/SCDO_1000474	Clinical or Research Assessment Data Element		A data element in a SickleInAfrica data capture instrument.
http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element	http://purl.obolibrary.org/obo/SCDO_1000508	SickleInAfrica Data Element		A data element in the SickleInAfrica core data capture instrument.
http://purl.obolibrary.org/obo/SCDO_1000510	SickleInAfrica CDE - Urinary Albumin Concentration Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the concentration of albumin in the respondent's urine.
http://purl.obolibrary.org/obo/SCDO_1000512	SickleInAfrica CDE - Informed Consent Obtained Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records whether the respondent has consented as necessary.
http://purl.obolibrary.org/obo/SCDO_1000513	Informed Consent Obtained	http://purl.obolibrary.org/obo/SCDO_1000490	Consent Status		An indication of whether informed consent was obtained from the respondent and/or their proxy.
http://purl.obolibrary.org/obo/SCDO_1000514	Study Enrollment Consent	http://purl.obolibrary.org/obo/SCDO_0007087	Informed Consent		Voluntary authorization given by a respondent and/or their proxy to be enrolled into a study as a research subject.
http://purl.obolibrary.org/obo/SCDO_1000515	Specimen Storage Consent	http://purl.obolibrary.org/obo/SCDO_0007087	Informed Consent		Voluntary authorization given by a study respondent and/or their proxy to have their specimen(s) stored.
http://purl.obolibrary.org/obo/SCDO_1000516	Genetic Material Storage Consent	http://purl.obolibrary.org/obo/SCDO_0007087	Informed Consent		Voluntary authorization given by a study paticipant to have their genetic material stored.
http://purl.obolibrary.org/obo/SCDO_1000520	SickleInAfrica CDE - Type of Informed Consent Obtained Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the type(s) of informed consent obtained from the participant.
http://purl.obolibrary.org/obo/SCDO_1000521	Type of Informed Consent Obtained	http://purl.obolibrary.org/obo/SCDO_1000490	Consent Status		An indication of the type of informed consent that was obtained from the respondent and/or their proxies.
http://purl.obolibrary.org/obo/SCDO_1000522	Temporal Observable of Consent	http://purl.obolibrary.org/obo/SCDO_0007597	Descriptor of Consent		Time-related information that can be observed and is related to consent.
http://purl.obolibrary.org/obo/SCDO_1000527	Calculated Current Age	http://purl.obolibrary.org/obo/SCDO_0000304	Current Age		The current age of a patient, calculated using the current date and the patient's date of birth.
http://purl.obolibrary.org/obo/SCDO_1000532	SickleInAfrica CDE - Date of Signing Consent Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the date on which the respondent signed the consent form for the relevant study.
http://purl.obolibrary.org/obo/SCDO_1000533	SickleInAfrica CDE - Consented By Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the name of the person who managed the process of consenting the respondent.
http://purl.obolibrary.org/obo/SCDO_1000534	Blood Transfusion Since Last Visit	http://purl.obolibrary.org/obo/SCDO_1000318	Diagnostic Instrument Measurement		An indication of whether the respondent has had a blood transfusion since their last hospital visit. This is any transfusion before enrolment if it is the patient's first hospital visit.
http://purl.obolibrary.org/obo/SCDO_1000535	Consent Form Uploaded	http://purl.obolibrary.org/obo/SCDO_1000490	Consent Status		An indication of whether the consent form used for obtaining informed consent from the respondent has been uploaded to the relevant electronic system.
http://purl.obolibrary.org/obo/SCDO_1000536	Consented By	http://purl.obolibrary.org/obo/SCDO_0007597	Descriptor of Consent		The name of the person who conducted consenting of the respondent.
http://purl.obolibrary.org/obo/SCDO_1000537	Temporal Observable	http://purl.obolibrary.org/obo/SCDO_0001000	SCDO		Time-related information that can be observed.
http://purl.obolibrary.org/obo/SCDO_1000538	Diagnosis Temporal Observable	http://purl.obolibrary.org/obo/SCDO_1000553	Diagnosis Descriptor		Time-related information that can be observed and is related to a diagnosis.
http://purl.obolibrary.org/obo/SCDO_1000539	SickleInAfrica CDE - Visit Date Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the visit date, in the format dd/mm/yyyy.
http://purl.obolibrary.org/obo/SCDO_1000542	SickleInAfrica CDE - Site Participant Number Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the site-specific unique identifier that was assigned to the study participant by the data collectors at the data collection site.
http://purl.obolibrary.org/obo/SCDO_1000543	SickleInAfrica CDE - Date of Birth Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the respondent's date of birth in the format dd/mm/yyyy.
http://purl.obolibrary.org/obo/SCDO_1000545	Calculated Current Age (Months)	http://purl.obolibrary.org/obo/SCDO_1000527	Calculated Current Age		The current age of a patient, calculated using the current date and the patient's date of birth and provided in months.
http://purl.obolibrary.org/obo/SCDO_1000546	Self-Reported Current Age (Years)	http://purl.obolibrary.org/obo/SCDO_0000304	Current Age		The length of time that a person has lived since their birth up until the current day, as reported in years by the respondent.
http://purl.obolibrary.org/obo/SCDO_1000547	SickleInAfrica CDE - Self-Reported Age Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the respondent's age, as reported by the respondent in years.
http://purl.obolibrary.org/obo/SCDO_1000548	SickleInAfrica CDE - Current Marital Status Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the respondent's current marital status.
http://purl.obolibrary.org/obo/SCDO_1000549	SickleInAfrica CDE - Date of Transfusion Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the date on which the respondent last received a blood transfusion.
http://purl.obolibrary.org/obo/SCDO_1000550	SickleInAfrica CDE - SCD Other Test Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the type of SCD test that was used to diagnose the respondent, in the case where the type of test was not listed as an answer option in a  previous data element.
http://purl.obolibrary.org/obo/SCDO_1000551	SickleInAfrica CDE - Sex Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the respondent's sex.
http://purl.obolibrary.org/obo/SCDO_1000552	SickleInAfrica CDE - Date of Diagnosis Known Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records whether the respondent knows the date of their SCD diagnosis.
http://purl.obolibrary.org/obo/SCDO_1000553	Diagnosis Descriptor	http://purl.obolibrary.org/obo/SCDO_0000379	Diagnostics		Information or a description that further describes a diagnosis.
http://purl.obolibrary.org/obo/SCDO_1000554	Date of Diagnosis Known	http://purl.obolibrary.org/obo/SCDO_1000538	Diagnosis Temporal Observable		An indication of whether the date of the respondent's diagnosis of a disease is known by the respondent or the respondent's guardian.
http://purl.obolibrary.org/obo/SCDO_1000555	Date of SCD Diagnosis Known	http://purl.obolibrary.org/obo/SCDO_1000554	Date of Diagnosis Known		An indication of whether the date of the respondent's SCD diagnosis is known by the respondent or the respondent's guardian.
http://purl.obolibrary.org/obo/SCDO_1000556	SickleInAfrica CDE - Date of Diagnosis Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the respondent's date of diagnosis in the format dd/mm/yyyy.
http://purl.obolibrary.org/obo/SCDO_1000558	Date of SCD Diagnosis	http://purl.obolibrary.org/obo/NCIT_C164339	Date of Diagnosis		The date on which a diagnosis of sickle cell disease was made.
http://purl.obolibrary.org/obo/SCDO_1000566	Date of Blood Transfusion	http://purl.obolibrary.org/obo/SCDO_1000590	SCD Management Details		The date on which a patient received a blood transfusion.
http://purl.obolibrary.org/obo/SCDO_1000568	Year of SCD Diagnosis	http://purl.obolibrary.org/obo/NCIT_C168823	Year of Diagnosis		The year in which a sickle cell disease diagnosis was made.
http://purl.obolibrary.org/obo/SCDO_1000569	Month of Diagnosis	http://purl.obolibrary.org/obo/SCDO_1000538	Diagnosis Temporal Observable		The month when a diagnosis was assigned to an individual's condition.
http://purl.obolibrary.org/obo/SCDO_1000570	Month of SCD Diagnosis	http://purl.obolibrary.org/obo/SCDO_1000569	Month of Diagnosis		The month when a sickle cell disease diagnosis was made.
http://purl.obolibrary.org/obo/SCDO_1000571	SickleInAfrica CDE - Month of Diagnosis Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the month of the year in which the respondent was diagnosed with SCD.
http://purl.obolibrary.org/obo/SCDO_1000572	Diagnosis	http://purl.obolibrary.org/obo/NCIT_C18772	Personal Medical History		A diagnosis is the result of a medical investigation to identify a disorder from its signs and symptoms.
http://purl.obolibrary.org/obo/SCDO_1000573	SickleInAfrica CDE - SCD Test Result Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the respondent's SCD test result.
http://purl.obolibrary.org/obo/SCDO_1000574	SCD Test Result	http://purl.obolibrary.org/obo/CMO_0000508	Hemoglobin Measurement		The result of a medical investigation to identify the type of sickle cell disease that a person has.
http://purl.obolibrary.org/obo/SCDO_1000575	SickleInAfrica CDE - Type of SCD Test Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the type of SCD test that was used to diagnose the respondent.
http://purl.obolibrary.org/obo/SCDO_1000576	Diagnostic Measurement Descriptor	http://purl.obolibrary.org/obo/SCDO_0000379	Diagnostics		A piece of information that further describes a diagnostic measurement.
http://purl.obolibrary.org/obo/SCDO_1000577	Type of SCD Test	http://purl.obolibrary.org/obo/SCDO_1000576	Diagnostic Measurement Descriptor		The type of test that was used to obtain a sickle cell disease diagnosis.
http://purl.obolibrary.org/obo/SCDO_1000578	SickleInAfrica CDE - SCD Test Other Result Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the respondent's SCD test result, in the case where the specific result was not listed as an answer option in a previous data element.
http://purl.obolibrary.org/obo/SCDO_1000579	SickleInAfrica CDE - Blood Group Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the respondent's ABO Blood Group.
http://purl.obolibrary.org/obo/SCDO_1000580	Hemoglobin Electrophoresis	http://purl.obolibrary.org/obo/SCDO_0000424	Electrophoresis		A blood test that uses the principles of gel electrophoresis to separate out the various types of hemoglobin in order to determine the level of different types of hemoglobin in the blood.
http://purl.obolibrary.org/obo/SCDO_1000582	Blood Type A Positive	http://purl.obolibrary.org/obo/HP_0032224	ABO Blood Group		A blood type containing type A red blood cell surface markers, with the presence of a protein called rhesus (Rh) factor.
http://purl.obolibrary.org/obo/SCDO_1000583	Blood Type A Negative	http://purl.obolibrary.org/obo/HP_0032224	ABO Blood Group		A blood type containing type A red blood cell surface markers, with the absence of a protein called rhesus (Rh) factor.
http://purl.obolibrary.org/obo/SCDO_1000584	Blood Type B Positive	http://purl.obolibrary.org/obo/HP_0032224	ABO Blood Group		A blood type containing type B red blood cell surface markers, with the presence of a protein called rhesus (Rh) factor.
http://purl.obolibrary.org/obo/SCDO_1000585	Blood Type B Negative	http://purl.obolibrary.org/obo/HP_0032224	ABO Blood Group		A blood type containing type B red blood cell surface markers, with the absence of a protein called rhesus (Rh) factor.
http://purl.obolibrary.org/obo/SCDO_1000586	Blood Type O Positive	http://purl.obolibrary.org/obo/HP_0032224	ABO Blood Group		A blood type containing no surface markers on red blood cells, with the presence of a protein called rhesus (Rh) factor.
http://purl.obolibrary.org/obo/SCDO_1000587	Blood Type O Negative	http://purl.obolibrary.org/obo/HP_0032224	ABO Blood Group		A blood type containing no surface markers on red blood cells, with the absence of a protein called rhesus (Rh) factor.
http://purl.obolibrary.org/obo/SCDO_1000588	Blood Type AB Positive	http://purl.obolibrary.org/obo/HP_0032224	ABO Blood Group		A blood type containing both type A and B red blood cell surface markers, with the presence of a protein called rhesus (Rh) factor.
http://purl.obolibrary.org/obo/SCDO_1000589	Blood Type AB Negative	http://purl.obolibrary.org/obo/HP_0032224	ABO Blood Group		A blood type containing both type A and B red blood cell surface markers, with the absence of a protein called rhesus (Rh) factor
http://purl.obolibrary.org/obo/SCDO_1000590	SCD Management Details	http://purl.obolibrary.org/obo/NCIT_C19332	Personal Attribute		Information about how a patient's SCD is being managed.
http://purl.obolibrary.org/obo/SCDO_1000591	SickleInAfrica CDE - Hydroxyurea Use Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the respondent's hydroxyurea use status (i.e. an indication of whether the respondent is using hydroxyurea).
http://purl.obolibrary.org/obo/SCDO_1000592	Hydroxyurea Use Status	http://purl.obolibrary.org/obo/SCDO_1000590	SCD Management Details		An indication of whether the respondent is using hydroxyurea.
http://purl.obolibrary.org/obo/SCDO_1000593	SickleInAfrica CDE - Hydroxyurea Initiation Date Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the date on which the respondent started hydroxyurea therapy, in the format dd/mm/yyyy.
http://purl.obolibrary.org/obo/SCDO_1000594	Date of Hydroxyurea Therapy Initiation	http://purl.obolibrary.org/obo/SCDO_1000537	Temporal Observable		The date on which hydroxyurea therapy was initiated.
http://purl.obolibrary.org/obo/SCDO_1000595	SickleInAfrica CDE - Penicillin V Use Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records whether the respondent is using penicillin V as a prophylaxis against bacterial infections.
http://purl.obolibrary.org/obo/SCDO_1000596	Penicillin V Prophylaxis Use Status	http://purl.obolibrary.org/obo/SCDO_1000590	SCD Management Details		An indication of whether the respondent is using penicillin V prophylaxis.
http://purl.obolibrary.org/obo/SCDO_1000597	SickleInAfrica CDE - Folic Acid Use Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the respondent's folic acid use status (i.e. an indication of whether the respondent is using folic acid).
http://purl.obolibrary.org/obo/SCDO_1000598	Folic Acid Use Status	http://purl.obolibrary.org/obo/SCDO_1000590	SCD Management Details		An indication of whether the respondent is using folic acid.
http://purl.obolibrary.org/obo/SCDO_1000599	Malaria Prophylaxis Status	http://purl.obolibrary.org/obo/SCDO_1000590	SCD Management Details		An indication of whether the respondent is using malaria prophylaxis.
http://purl.obolibrary.org/obo/SCDO_1000600	SickleInAfrica CDE - Malaria Prophylaxis Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records whether the respondent is using malaria chemoprophylaxis (drugs that prevent malaria).
http://purl.obolibrary.org/obo/SCDO_1000601	SickleInAfrica CDE - Pneumococcal Vaccination Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records whether the respondent's pneumococcal vaccination is up to date.
http://purl.obolibrary.org/obo/SCDO_1000602	Pneumococcal Vaccination Status	http://purl.obolibrary.org/obo/SCDO_1000590	SCD Management Details		An indication of whether the respondent is up to date with their pneumococcal vaccinations.
http://purl.obolibrary.org/obo/SCDO_1000604	Management Details Added By	http://purl.obolibrary.org/obo/SCDO_1000590	SCD Management Details		The person who recorded the information about how a patient's condition is being managed.
http://purl.obolibrary.org/obo/SCDO_1000605	Blood Urea Analysis	http://purl.obolibrary.org/obo/SCDO_0000133	Blood Test		Any assay which measures the amount, level or concentration of urea in whole blood.
http://purl.obolibrary.org/obo/SCDO_1000606	Management Details Add Date	http://purl.obolibrary.org/obo/SCDO_1000590	SCD Management Details		The date on which the respondent's management details were added/recorded.
http://purl.obolibrary.org/obo/SCDO_1000607	SickleInAfrica CDE - Red Blood Cell Count Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the red blood cell count in the respondent's blood, as measured by a complete blood count.
http://purl.obolibrary.org/obo/SCDO_1000611	SickleInAfrica CDE - White Blood Cell Count Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the white blood cell count in the respondent's blood, as measured by a complete blood count.
http://purl.obolibrary.org/obo/SCDO_1000612	Abnormal Leukocyte Morphology	http://purl.obolibrary.org/obo/HP_0002715	Abnormality of the Immune System		Any structural abnormality of leukocytes (nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue).
http://purl.obolibrary.org/obo/SCDO_1000615	SickleInAfrica CDE - Platelet Count Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the platelet count in the respondent's blood, as measured by a complete blood count.
http://purl.obolibrary.org/obo/SCDO_1000619	SickleInAfrica CDE - Hemoglobin - CBC Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the concentration of hemoglobin in the respondent's blood, as measured by a complete blood count.
http://purl.obolibrary.org/obo/SCDO_1000621	SickleInAfrica CDE - Mean Cell Volume Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the respondent's mean cell volume (MCV), as measured by a complete blood count.
http://purl.obolibrary.org/obo/SCDO_1000627	SickleInAfrica CDE - Mean Cell Hemoglobin Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the respondent's mean cell hemoglobin  (MCH), as measured by a complete blood count.
http://purl.obolibrary.org/obo/SCDO_1000630	SickleInAfrica CDE - Mean Cell Hemoglobin Concentration Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the respondent's mean cell hemoglobin concentration (MCHC), as measured by a complete blood count.
http://purl.obolibrary.org/obo/SCDO_1000637	SickleInAfrica CDE - Red Cell Distribution Width Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the respondent's red cell distribution width, as measured by a complete blood count.
http://purl.obolibrary.org/obo/SCDO_1000638	Red Blood Cell Distribution Width	http://purl.obolibrary.org/obo/CMO_0001356	Red Blood Cell Measurement		Red blood cell distribution width (RDW or RDW-CV or RCDW and RDW-SD) is a measure of the range of variation of red blood cell (RBC) volume that is reported as part of a standard complete blood count. Usually red blood cells are a standard size of about 6-8 μm in diameter. Certain disorders, however, cause a significant variation in cell size. Higher RDW values indicate greater variation in size. Normal reference range of RDW-CV in human red blood cells is 11.5-14.5%.[1] If anemia is observed, RDW test results are often used together with mean corpuscular volume (MCV) results to determine the possible causes of the anemia. It is mainly used to differentiate an anemia of mixed causes from an anemia of a single cause.
http://purl.obolibrary.org/obo/SCDO_1000645	SickleInAfrica CDE - Serum Creatinine Concentration Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the level of serum creatinine in the respondent's blood.
http://purl.obolibrary.org/obo/SCDO_1000649	Elevated Serum Creatinine	http://purl.obolibrary.org/obo/HP_0012100	Abnormal Circulating Creatinine Level		An abnormally increased amount of creatinine in the blood.
http://purl.obolibrary.org/obo/SCDO_1000650	SickleInAfrica CDE - Urinary Creatinine Concentration Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the concentration of creatinine in the respondent's urine.
http://purl.obolibrary.org/obo/SCDO_1000657	SickleInAfrica CDE - Alanine Aminotransferase Level Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the level of alanine aminotransferase in the respondent's blood.
http://purl.obolibrary.org/obo/SCDO_1000660	SickleInAfrica CDE - Aspartate Aminotransferase Level Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the level of aspartate aminotransferase in the respondent's blood.
http://purl.obolibrary.org/obo/SCDO_1000662	SickleInAfrica CDE - Alkaline Phosphatase Level Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the level of alkaline phosphatase in the respondent's blood.
http://purl.obolibrary.org/obo/SCDO_1000663	Alkaline Phosphatase Blood Test	http://purl.obolibrary.org/obo/NCIT_C74954	Liver Function Test		A quantitative measurement of alkaline phosphatase present in a blood sample.
http://purl.obolibrary.org/obo/SCDO_1000669	Sickle SCAN Rapid Test	http://purl.obolibrary.org/obo/SCDO_1000577	Type of SCD Test		A multiplexed qualitative point-of-care immunoassay used for the rapid diagnosis of sickle cell disorders. The test is made up of three indicators which detect the presence of hemoglobins A, S, and C, allowing the user to rapidly distinguish between normal, carrier, and sickle cell samples.
http://purl.obolibrary.org/obo/SCDO_1000673	Current Partner Status	http://purl.obolibrary.org/obo/NCIT_C16495	Demographic Factor		An indication of a person's current status in terms of living with a person as though married (in a romantic relationship and living together but not married).
http://purl.obolibrary.org/obo/SCDO_1000679	Past Partner Status	http://purl.obolibrary.org/obo/NCIT_C16495	Demographic Factor		An indication of whether a person has previously lived with someone as though married (in a romantic relationship and lived together but were not married).
http://purl.obolibrary.org/obo/SCDO_1000680	SickleInAfrica CDE - Total Bilirubin Concentration Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the level of billirubin in the respondent's blood.
http://purl.obolibrary.org/obo/SCDO_1000682	SickleInAfrica CDE - Lactate Dehydrogenase Level Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the level of lactate dehydrogenase in the respondent's blood.
http://purl.obolibrary.org/obo/SCDO_1000684	Reduced Lactate Dehydrogenase Level	http://purl.obolibrary.org/obo/HP_0045040	Abnormal Lactate Dehydrogenase Level		A decreased or reduced level of the enzyme lactate dehydrogenase in serum.
http://purl.obolibrary.org/obo/SCDO_1000685	SickleInAfrica CDE - Reticulocyte Count Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the reticulocyte count in the respondent's blood, as measured by a complete blood count.
http://purl.obolibrary.org/obo/SCDO_1000686	Reticulocyte Count Assay	http://purl.obolibrary.org/obo/SCDO_0000133	Blood Test		A test used to measure the reticulocyte count (number of reticulocytes in a given volume of blood).
http://purl.obolibrary.org/obo/SCDO_1000687	SickleInAfrica CDE - Hb Assay Results Recorded Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the hemoglobins for which assay results were recorded.
http://purl.obolibrary.org/obo/SCDO_1000688	Hemoglobin Assay Results Recorded	http://purl.obolibrary.org/obo/SCDO_1000576	Diagnostic Measurement Descriptor		The hemoglobins for which assay results were recorded.
http://purl.obolibrary.org/obo/SCDO_1000689	Hemoglobin G-Philadelphia	http://purl.obolibrary.org/obo/SCDO_0006921	Hemoglobin Variant		Hemoglobin G Philadelphia (HbG Phil) is a structural variant of the hemoglobin molecule that involves the alpha chain rather than the beta chain. It has a frequency of about 1 in 5,000 African Americans, but has been reported in other ethnic groups in the Mediterranean region as well, HbG Phil itself has no clinical consequences. The only finding of clinical interest is the mild microcytosis. While this molecule has no clinical consequences, the presence helps to distinguish HbG from HbD that shares its electrophoretic migration on HPLC and gel electrophoresis and which does have consequences when it occurs with sickle trait.
http://purl.obolibrary.org/obo/SCDO_1000690	Hemoglobin A Level	http://purl.obolibrary.org/obo/SCDO_0000546	Hemoglobin Profile		The amount of hemoglobin A present in a specified volume of blood.
http://purl.obolibrary.org/obo/SCDO_1000691	SickleInAfrica CDE - Hemoglobin A Level Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin A.
http://purl.obolibrary.org/obo/SCDO_1000692	Hemoglobin S Level	http://purl.obolibrary.org/obo/SCDO_0000546	Hemoglobin Profile		The amount of hemoglobin S present in a specified volume of blood.
http://purl.obolibrary.org/obo/SCDO_1000693	SickleInAfrica CDE - Hemoglobin S Level Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin S.
http://purl.obolibrary.org/obo/SCDO_1000694	SickleInAfrica CDE - Hemoglobin C Level Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin C.
http://purl.obolibrary.org/obo/SCDO_1000695	Hemoglobin C Level	http://purl.obolibrary.org/obo/SCDO_0000546	Hemoglobin Profile		The amount of hemoglobin C present in a specified volume of blood.
http://purl.obolibrary.org/obo/SCDO_1000696	SickleInAfrica CDE - Hemoglobin E Level Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin E.
http://purl.obolibrary.org/obo/SCDO_1000697	Hemoglobin E Level	http://purl.obolibrary.org/obo/SCDO_0000546	Hemoglobin Profile		The amount of hemoglobin E present in a specified volume of blood.
http://purl.obolibrary.org/obo/SCDO_1000698	Hemoglobin A2 Level	http://purl.obolibrary.org/obo/SCDO_0000546	Hemoglobin Profile		The amount of hemoglobin A2 present in a specified volume of blood.
http://purl.obolibrary.org/obo/SCDO_1000699	SickleInAfrica CDE - Hemoglobin A2 Level Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin A2.
http://purl.obolibrary.org/obo/SCDO_1000700	SickleInAfrica CDE - Hemoglobin D-Punjab Level Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin D-Punjab.
http://purl.obolibrary.org/obo/SCDO_1000701	Hemoglobin D-Punjab Level	http://purl.obolibrary.org/obo/SCDO_0000546	Hemoglobin Profile		The amount of hemoglobin D-Punjab present in a specified volume of blood.
http://purl.obolibrary.org/obo/SCDO_1000702	SickleInAfrica CDE - Hemoglobin G-Philadelphia Level Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin G-Philadelphia.
http://purl.obolibrary.org/obo/SCDO_1000703	Hemoglobin G-Philadelphia Level	http://purl.obolibrary.org/obo/SCDO_0000546	Hemoglobin Profile		The amount of hemoglobin G-Philadelphia present in a specified volume of blood.
http://purl.obolibrary.org/obo/SCDO_1000704	SickleInAfrica CDE - Hemoglobin O-Arab Level Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin O-Arab.
http://purl.obolibrary.org/obo/SCDO_1000705	Hemoglobin O-Arab Level	http://purl.obolibrary.org/obo/SCDO_0000546	Hemoglobin Profile		The amount of hemoglobin O-Arab present in a specified volume of blood.
http://purl.obolibrary.org/obo/SCDO_1000706	SickleInAfrica CDE - Hemoglobin F Level Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the proportion of the respondent's hemoglobin that consists of hemoglobin F.
http://purl.obolibrary.org/obo/SCDO_1000707	Hemoglobin F Level	http://purl.obolibrary.org/obo/SCDO_0000546	Hemoglobin Profile		The amount of hemoglobin F present in a specified volume of blood.
http://purl.obolibrary.org/obo/SCDO_1000708	Sex of Spouse	http://purl.obolibrary.org/obo/NCIT_C16495	Demographic Factor		The sex of the respondent's spouse, as provided by the respondent.
http://purl.obolibrary.org/obo/SCDO_1000709	Sex of Partner	http://purl.obolibrary.org/obo/NCIT_C16495	Demographic Factor		The sex of the respondent's partner (where the partner is not a spouse), as provided by the respondent.
http://purl.obolibrary.org/obo/SCDO_1000711	SickleInAfrica CDE - Body Temperature Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the respondent's body temperature.
http://purl.obolibrary.org/obo/SCDO_1000714	SickleInAfrica CDE - Respiratory Rate Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the respondent's respiratory rate.
http://purl.obolibrary.org/obo/SCDO_1000717	SickleInAfrica CDE - Partial Pressure CO2 Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the respondent's partial pressure of carbon dioxide in their arterial blood, as measured by an arterial blood gas test.
http://purl.obolibrary.org/obo/SCDO_1000722	SickleInAfrica CDE - Partial Pressure O2 Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the respondent's partial pressure of oxygen their arterial blood, as measured by an arterial blood gas test.
http://purl.obolibrary.org/obo/SCDO_1000723	Partial Pressure of Oxygen	http://purl.obolibrary.org/obo/CMO_0000225	Arterial Blood Gas Measurement		The pressure exerted by oxygen dissolved in the blood, indicating how well oxygen is able to move from the airspace of the lungs into the blood.
http://purl.obolibrary.org/obo/SCDO_1000724	SickleInAfrica CDE - Oxyhemoglobin Saturation Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the respondent's arterial oxygen saturation (oxyhemoglobin saturation), as measured by an arterial blood gas test.
http://purl.obolibrary.org/obo/SCDO_1000725	SickleInAfrica CDE - Carboxyhemoglobin Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the respondent's carboxyhemoglobin to total hemoglobin ratio, as measured by an arterial blood gas test.
http://purl.obolibrary.org/obo/SCDO_1000726	SickleInAfrica CDE - Methemoglobin Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the respondent's methemoglobin to total hemoglobin ratio, as measured by an arterial blood gas test.
http://purl.obolibrary.org/obo/SCDO_1000727	Methemoglobin to Total Hemoglobin Ratio	http://purl.obolibrary.org/obo/CMO_0000508	Hemoglobin Measurement		The ratio of methemoglobin compared to total hemoglobin present in a sample. The measurement may be expressed as a ratio or percentage.
http://purl.obolibrary.org/obo/SCDO_1000728	Carboxyhemoglobin to Total Hemoglobin Ratio	http://purl.obolibrary.org/obo/CMO_0000508	Hemoglobin Measurement		The ratio of carboxyhemoglobin compared to total hemoglobin present in a sample. The measurement may be expressed as a ratio or percentage.
http://purl.obolibrary.org/obo/SCDO_1000729	Increased Methemoglobin	http://purl.obolibrary.org/obo/HP_0020063	Increased Hemoglobin Concentration		An elevated concentration in the blood of methemoglobin, which is the ferric (Fe(3+)) form of hemoglobin.
http://purl.obolibrary.org/obo/SCDO_1000730	Site Participant Number	http://purl.obolibrary.org/obo/NCIT_C69256	Subject Unique Identifier		A site-specific unique identifier assigned to a study participant by the data collectors at the data collection site.
http://purl.obolibrary.org/obo/SCDO_1000731	SCD Passport Number	http://purl.obolibrary.org/obo/NCIT_C69256	Subject Unique Identifier		A unique identifier provided on SCD passports.
http://purl.obolibrary.org/obo/SCDO_1000732	SickleInAfrica CDE - SickleInAfrica Participant Number	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the unique identifier that was assigned to the study participant's data when it was registered in the SickleInAfrica data registry.
http://purl.obolibrary.org/obo/SCDO_1000734	SickleInAfrica CDE - Age In Months Calculation	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that calculates the respondent's age in months, using the visit date and birth date collected by other core data elements.
http://purl.obolibrary.org/obo/SCDO_1000738	SickleInAfrica Core Data Element Instrument	http://purl.obolibrary.org/obo/NCIT_C91105	Clinical or Research Assessment Questionnaire		A data capture instrument designed and applied by the Sickle In Africa Consortium.
http://purl.obolibrary.org/obo/SCDO_1000751	SickleInAfrica CDE - Total Hemoglobin Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the total concentration of hemoglobin in the respondent's blood.
http://purl.obolibrary.org/obo/SCDO_1000753	Body Temperature - Oral Measurement Assay	http://purl.obolibrary.org/obo/OBI_0002140	Temperature Measurement Assay		An assay to determine the body temperature of an evaluant using an oral thermometer.
http://purl.obolibrary.org/obo/SCDO_1000754	Body Temperature - Tympanic Measurement Assay	http://purl.obolibrary.org/obo/OBI_0002140	Temperature Measurement Assay		An assay to determine the body temperature of an evaluant using a tympanic (i.e. ear) thermometer.
http://purl.obolibrary.org/obo/SCDO_1000755	Oral Temperature	http://purl.obolibrary.org/obo/CMO_0000015	Body Temperature		The temperature of the oral cavity.
http://purl.obolibrary.org/obo/SCDO_1000756	Tympanic Temperature	http://purl.obolibrary.org/obo/CMO_0000015	Body Temperature		The temperature of the external acoustic tube.
http://purl.obolibrary.org/obo/SCDO_1000757	Rectal Temperature	http://purl.obolibrary.org/obo/CMO_0000015	Body Temperature		The temperature of the lumen of the rectum.
http://purl.obolibrary.org/obo/SCDO_1000758	Axillary Temperature	http://purl.obolibrary.org/obo/CMO_0000015	Body Temperature		The temperature of the axillary fossa.
http://purl.obolibrary.org/obo/SCDO_1000759	SickleInAfrica CDE - Type of Temperature Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the type of body temperature that was taken for the respondent.
http://purl.obolibrary.org/obo/SCDO_1000766	Year 1900 - Current	http://purl.obolibrary.org/obo/NCIT_C91106	Clinical or Research Assessment Answer		An answer to a question where the answer is a year between 1900 and the current year, selected from a provided list of years.
http://purl.obolibrary.org/obo/SCDO_1000767	Month 1 - 12	http://purl.obolibrary.org/obo/NCIT_C91106	Clinical or Research Assessment Answer		An answer to a question where the answer is a month between 1 - 12, selected form a list of months.
http://purl.obolibrary.org/obo/SCDO_1000769	Basique	http://purl.obolibrary.org/obo/SCDO_1000577	Type of SCD Test		Waiting for description for this.
http://purl.obolibrary.org/obo/SCDO_1000774	D57.03 Hb-SS disease with cerebral vascular involvement	http://purl.obolibrary.org/obo/SCDO_0000312	D57.0 Hb-SS disease with crisis		-
http://purl.obolibrary.org/obo/SCDO_1000775	D57.09 Hb-SS disease with crisis with other specified complication	http://purl.obolibrary.org/obo/SCDO_0000312	D57.0 Hb-SS disease with crisis		-
http://purl.obolibrary.org/obo/SCDO_1000783	Normal Hemoglobin Concentration	http://purl.obolibrary.org/obo/SCDO_1000821	Normal Hematopoietic System Phenotype		When there is no deviation from the normal concentration of hemoglobin in the blood.
http://purl.obolibrary.org/obo/SCDO_1000784	Absent Hemoglobin S	http://purl.obolibrary.org/obo/SCDO_1000783	Normal Hemoglobin Concentration		A lack of production of hemoglobin S.
http://purl.obolibrary.org/obo/SCDO_1000786	D57.213 Sickle-cell/Hb-C disease with cerebral vascular involvement	http://purl.obolibrary.org/obo/SCDO_0000318	D57.21 Sickle-cell/Hb-C disease with crisis		-
http://purl.obolibrary.org/obo/SCDO_1000787	D57.218 Sickle-cell/Hb-C disease with crisis with other specified complication	http://purl.obolibrary.org/obo/SCDO_0000318	D57.21 Sickle-cell/Hb-C disease with crisis		-
http://purl.obolibrary.org/obo/SCDO_1000788	D57.413 Sickle-cell thalassemia, unspecified, with cerebral vascular involvement	http://purl.obolibrary.org/obo/SCDO_0000325	D57.41 Sickle-cell thalassemia, unspecified, with crisis		-
http://purl.obolibrary.org/obo/SCDO_1000789	D57.418 Sickle-cell thalassemia, unspecified, with crisis with other specified complication	http://purl.obolibrary.org/obo/SCDO_0000325	D57.41 Sickle-cell thalassemia, unspecified, with crisis		-
http://purl.obolibrary.org/obo/SCDO_1000790	D57.42 Sickle-cell thalassemia beta zero without crisis	http://purl.obolibrary.org/obo/SCDO_0000323	D57.4 Sickle-cell thalassemia		-
http://purl.obolibrary.org/obo/SCDO_1000791	D57.43 Sickle-cell thalassemia beta zero with crisis	http://purl.obolibrary.org/obo/SCDO_0000323	D57.4 Sickle-cell thalassemia		-
http://purl.obolibrary.org/obo/SCDO_1000792	D57.431 Sickle-cell thalassemia beta zero with acute chest syndrome	http://purl.obolibrary.org/obo/SCDO_1000791	D57.43 Sickle-cell thalassemia beta zero with crisis		-
http://purl.obolibrary.org/obo/SCDO_1000793	D57.432 Sickle-cell thalassemia beta zero with splenic sequestration	http://purl.obolibrary.org/obo/SCDO_1000791	D57.43 Sickle-cell thalassemia beta zero with crisis		-
http://purl.obolibrary.org/obo/SCDO_1000794	D57.433 Sickle-cell thalassemia beta zero with cerebral vascular involvement	http://purl.obolibrary.org/obo/SCDO_1000791	D57.43 Sickle-cell thalassemia beta zero with crisis		-
http://purl.obolibrary.org/obo/SCDO_1000795	D57.438 Sickle-cell thalassemia beta zero with crisis with other specified complication	http://purl.obolibrary.org/obo/SCDO_1000791	D57.43 Sickle-cell thalassemia beta zero with crisis		-
http://purl.obolibrary.org/obo/SCDO_1000796	D57.439 Sickle-cell thalassemia beta zero with crisis, unspecified	http://purl.obolibrary.org/obo/SCDO_1000791	D57.43 Sickle-cell thalassemia beta zero with crisis		-
http://purl.obolibrary.org/obo/SCDO_1000797	D57.44 Sickle-cell thalassemia beta plus without crisis	http://purl.obolibrary.org/obo/SCDO_0000323	D57.4 Sickle-cell thalassemia		-
http://purl.obolibrary.org/obo/SCDO_1000798	D57.45 Sickle-cell thalassemia beta plus with crisis	http://purl.obolibrary.org/obo/SCDO_0000323	D57.4 Sickle-cell thalassemia		-
http://purl.obolibrary.org/obo/SCDO_1000799	D57.451 Sickle-cell thalassemia beta plus with acute chest syndrome	http://purl.obolibrary.org/obo/SCDO_1000798	D57.45 Sickle-cell thalassemia beta plus with crisis		-
http://purl.obolibrary.org/obo/SCDO_1000800	D57.452 Sickle-cell thalassemia beta plus with splenic sequestration	http://purl.obolibrary.org/obo/SCDO_1000798	D57.45 Sickle-cell thalassemia beta plus with crisis		-
http://purl.obolibrary.org/obo/SCDO_1000801	D57.453 Sickle-cell thalassemia beta plus with cerebral vascular involvement	http://purl.obolibrary.org/obo/SCDO_1000798	D57.45 Sickle-cell thalassemia beta plus with crisis		-
http://purl.obolibrary.org/obo/SCDO_1000802	D57.458 Sickle-cell thalassemia beta plus with crisis with other specified complication	http://purl.obolibrary.org/obo/SCDO_1000798	D57.45 Sickle-cell thalassemia beta plus with crisis		-
http://purl.obolibrary.org/obo/SCDO_1000803	D57.459 Sickle-cell thalassemia beta plus with crisis, unspecified	http://purl.obolibrary.org/obo/SCDO_1000798	D57.45 Sickle-cell thalassemia beta plus with crisis		-
http://purl.obolibrary.org/obo/SCDO_1000804	D57.818 Other sickle-cell disorders with crisis with other specified complication	http://purl.obolibrary.org/obo/SCDO_0000331	D57.81 Other sickle-cell disorders with crisis		-
http://purl.obolibrary.org/obo/SCDO_1000805	D57.813 Other sickle-cell disorders with cerebral vascular involvement	http://purl.obolibrary.org/obo/SCDO_0000331	D57.81 Other sickle-cell disorders with crisis		-
http://purl.obolibrary.org/obo/SCDO_1000806	Absent Hemoglobin C	http://purl.obolibrary.org/obo/SCDO_1000783	Normal Hemoglobin Concentration		A lack of production of hemoglobin C.
http://purl.obolibrary.org/obo/SCDO_1000807	Increased Carboxyhemoglobin	http://purl.obolibrary.org/obo/HP_0020063	Increased Hemoglobin Concentration		An elevated concentration in the blood of carboxyhemoglobin, which is the form of hemoglobin where the heme group has formed a stable complex with carbon monoxide (CO).
http://purl.obolibrary.org/obo/SCDO_1000808	Decreased Arterial Oxygen Saturation	http://purl.obolibrary.org/obo/MP_0002329	Abnormal Blood Gas Level		An abnormal reduction in the amount of oxygen bound to hemoglobin in arterial blood expressed as a percentage of the maximal binding capacity.
http://purl.obolibrary.org/obo/SCDO_1000812	Normal Metabolism/Homeostasis Phenotype	http://purl.obolibrary.org/obo/MP_0005376	Metabolism/Homeostasis Phenotype		A phenotype of the body's metabolism or homeostasis that is not clinically abnormal.
http://purl.obolibrary.org/obo/SCDO_1000813	Normal Arterial Oxygen Saturation	http://purl.obolibrary.org/obo/SCDO_1000812	Normal Metabolism/Homeostasis Phenotype		When the degree to which oxygen is bound to hemoglobin in arterial blood is in the normal range.
http://purl.obolibrary.org/obo/SCDO_1000814	Normal Carboxyhemoglobin Level	http://purl.obolibrary.org/obo/SCDO_1000783	Normal Hemoglobin Concentration		When the level of carboxyhemoglobin detected in a sample of blood falls in the normal range for carboxyhemoglobin.
http://purl.obolibrary.org/obo/SCDO_1000815	Normal Methemoglobin Level	http://purl.obolibrary.org/obo/SCDO_1000783	Normal Hemoglobin Concentration		When the level of methemoglobin detected in a sample of blood falls in the normal range for methemoglobin.
http://purl.obolibrary.org/obo/SCDO_1000816	Absent Hemoglobin D-Punjab	http://purl.obolibrary.org/obo/SCDO_1000783	Normal Hemoglobin Concentration		A lack of production of hemoglobin D-Punjab.
http://purl.obolibrary.org/obo/SCDO_1000817	Absent Hemoglobin G-Philadelphia	http://purl.obolibrary.org/obo/SCDO_1000783	Normal Hemoglobin Concentration		A lack of production of hemoglobin G-Philadelphia.
http://purl.obolibrary.org/obo/SCDO_1000818	Absent Hemoglobin O-Arab	http://purl.obolibrary.org/obo/SCDO_1000783	Normal Hemoglobin Concentration		A lack of production of hemoglobin O-Arab.
http://purl.obolibrary.org/obo/SCDO_1000819	Decreased Partial Pressure of Oxygen	http://purl.obolibrary.org/obo/MP_0002329	Abnormal Blood Gas Level		An abnormal reduction in the pressure exerted by oxygen dissolved in the blood.
http://purl.obolibrary.org/obo/SCDO_1000820	Hematopoietic System Phenotype	http://purl.obolibrary.org/obo/OGMS_0000023	Phenotype		The observable morphological and physiological characteristics of the human blood cells or the organs associated with the development and formation of blood cells that are manifested through development and lifespan.
http://purl.obolibrary.org/obo/SCDO_1000821	Normal Hematopoietic System Phenotype	http://purl.obolibrary.org/obo/SCDO_1000820	Hematopoietic System Phenotype		A phenotype of the body's hematopoietic system  that is not clinically abnormal.
http://purl.obolibrary.org/obo/SCDO_1000822	Normal Red Blood Cell Count	http://purl.obolibrary.org/obo/SCDO_1000821	Normal Hematopoietic System Phenotype		When the number of red blood cells in a specified volume of blood falls in the normal range.
http://purl.obolibrary.org/obo/SCDO_1000823	Normal White Blood Cell Count	http://purl.obolibrary.org/obo/SCDO_1000821	Normal Hematopoietic System Phenotype		When the number of white blood cells in a specified volume of blood falls in the normal range.
http://purl.obolibrary.org/obo/SCDO_1000824	Normal Platelet Count	http://purl.obolibrary.org/obo/SCDO_1000821	Normal Hematopoietic System Phenotype		When the number of platelets in a specified volume of blood falls in the normal range.
http://purl.obolibrary.org/obo/SCDO_1000825	Normal Mean Corpuscular Volume	http://purl.obolibrary.org/obo/SCDO_1000821	Normal Hematopoietic System Phenotype		When the average volume or size of a single red blood cell falls in the normal range.
http://purl.obolibrary.org/obo/SCDO_1000827	Normal Mean Corpuscular Hemoglobin Concentration	http://purl.obolibrary.org/obo/SCDO_1000821	Normal Hematopoietic System Phenotype		When the amount of hemoglobin in a given volume of packed red blood cells falls in the normal range.
http://purl.obolibrary.org/obo/SCDO_1000828	Normal Red Blood Cell Distribution Width	http://purl.obolibrary.org/obo/SCDO_1000821	Normal Hematopoietic System Phenotype		When the range of variation of red blood cell (RBC) volume falls in the normal range.
http://purl.obolibrary.org/obo/SCDO_1000829	Normal Serum Creatinine	http://purl.obolibrary.org/obo/SCDO_1000812	Normal Metabolism/Homeostasis Phenotype		When the level of serum creatinine is in the normal range.
http://purl.obolibrary.org/obo/SCDO_1000830	Normal Serum Alanine Aminotransferase	http://purl.obolibrary.org/obo/SCDO_1000812	Normal Metabolism/Homeostasis Phenotype		When the level of serum alanine aminotransferase is in the normal range.
http://purl.obolibrary.org/obo/SCDO_1000831	Normal Serum Aspartate Aminotransferase	http://purl.obolibrary.org/obo/SCDO_1000812	Normal Metabolism/Homeostasis Phenotype		When the level of serum aspartate aminotransferase is in the normal range.
http://purl.obolibrary.org/obo/SCDO_1000832	Normal Serum Alkaline Phosphatase	http://purl.obolibrary.org/obo/SCDO_1000812	Normal Metabolism/Homeostasis Phenotype		When the level of serum alkaline aminotransferase is in the normal range.
http://purl.obolibrary.org/obo/SCDO_1000833	Normal Lactate Dehydrogenase Level	http://purl.obolibrary.org/obo/SCDO_1000812	Normal Metabolism/Homeostasis Phenotype		When the level of the enzyme lactate dehydrogenase in the serum is in the normal range.
http://purl.obolibrary.org/obo/SCDO_1000835	Normal Total Serum Bilirubin	http://purl.obolibrary.org/obo/SCDO_1000812	Normal Metabolism/Homeostasis Phenotype		When the total bilirubin level in the serum is in the normal range.
http://purl.obolibrary.org/obo/SCDO_1000836	Normal Urine Albumin Concentration	http://purl.obolibrary.org/obo/SCDO_1000812	Normal Metabolism/Homeostasis Phenotype		When the concentration of urinary albumin falls in the normal range.
http://purl.obolibrary.org/obo/SCDO_1000837	Normal Urine Creatinine Level	http://purl.obolibrary.org/obo/SCDO_1000812	Normal Metabolism/Homeostasis Phenotype		When the concentration of urine creatinine falls in the normal range.
http://purl.obolibrary.org/obo/SCDO_1000838	Normal Partial Pressure of Oxygen	http://purl.obolibrary.org/obo/SCDO_1000812	Normal Metabolism/Homeostasis Phenotype		When the pressure exerted by oxygen dissolved in the blood falls in the normal range.
http://purl.obolibrary.org/obo/SCDO_1000840	Decreased Partial Pressure of Carbon Dioxide	http://purl.obolibrary.org/obo/MP_0002329	Abnormal Blood Gas Level		An abnormal reduction in the pressure exerted by carbon dioxide dissolved in the blood.
http://purl.obolibrary.org/obo/SCDO_1000841	Increased Partial Pressure of Carbon Dioxide	http://purl.obolibrary.org/obo/MP_0002329	Abnormal Blood Gas Level		An abnormal increase in the pressure exerted by carbon dioxide dissolved in the blood.
http://purl.obolibrary.org/obo/SCDO_1000842	Hypocapnia	http://purl.obolibrary.org/obo/MP_0002329	Abnormal Blood Gas Level		Clinical manifestation consisting of a deficiency of carbon dioxide in arterial blood.
http://purl.obolibrary.org/obo/SCDO_1000843	Hypercapnia	http://purl.obolibrary.org/obo/MP_0002329	Abnormal Blood Gas Level		A clinical manifestation of abnormal increase in the amount of carbon dioxide in arterial blood.
http://purl.obolibrary.org/obo/SCDO_1000844	Hemoglobin S Present	http://purl.obolibrary.org/obo/HP_0020061	Abnormal Hemoglobin Concentration		When the abnormal hemoglobin, hemoglobin S (HbS), has been detected in a blood sample.
http://purl.obolibrary.org/obo/SCDO_1000847	SickleInAfrica CDE - Type of Visit Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the type of visit undertaken by a patient.
http://purl.obolibrary.org/obo/SCDO_1000849	Acute Clinical Visit	http://purl.obolibrary.org/obo/NCIT_C103165	Subject Visit Type		A clinical visit occuring because of an acute (severe with sudden onset) health condition.
http://purl.obolibrary.org/obo/SCDO_1000850	SickleInAfrica CDE - Medical Record Number Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the patient's medical record number.
http://purl.obolibrary.org/obo/SCDO_1000854	SickleInAfrica CDE - Hospital Name Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the name of the hospital that a patient visited.
http://purl.obolibrary.org/obo/SCDO_1000855	Hospital Name	http://purl.obolibrary.org/obo/EUPATH_0000310	Information on Observation Details		The name of the hospital visited by a patient.
http://purl.obolibrary.org/obo/SCDO_1000856	SickleInAfrica CDE - First Name Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records a respondent's first name.
http://purl.obolibrary.org/obo/SCDO_1000857	SickleInAfrica CDE - Middle Name Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records a respondent's middle name.
http://purl.obolibrary.org/obo/SCDO_1000858	First Name	http://purl.obolibrary.org/obo/NCIT_C25191	Person Name		A first name is a name that denotes a specific individual between members of a group of individuals, whose members usually share the same surname.
http://purl.obolibrary.org/obo/SCDO_1000860	Middle Name	http://purl.obolibrary.org/obo/NCIT_C25191	Person Name		A middle name is a name assigned to an individual that is not the first or last name.
http://purl.obolibrary.org/obo/SCDO_1000861	Last Name	http://purl.obolibrary.org/obo/NCIT_C25191	Person Name		A last name (surname) is a name added to a given name and is part of a personal name and is often the family name.
http://purl.obolibrary.org/obo/SCDO_1000862	SickleInAfrica CDE - Last Name Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records a respondent's last name.
http://purl.obolibrary.org/obo/SCDO_1000863	SickleInAfrica CDE - Height Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records a respondent's height.
http://purl.obolibrary.org/obo/SCDO_1000866	SickleInAfrica CDE - Weight Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records a respondent's measured weight.
http://purl.obolibrary.org/obo/SCDO_1000868	SickleInAfrica CDE - Ethnic Group Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the ethnic group to which a respondent belongs.
http://purl.obolibrary.org/obo/SCDO_1000869	SickleInAfrica CDE - Religion Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the religion of a respondent.
http://purl.obolibrary.org/obo/SCDO_1000870	SickleInAfrica CDE - Region Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the region in which the respondent lives.
http://purl.obolibrary.org/obo/SCDO_1000871	Street Name	http://purl.obolibrary.org/obo/NCIT_C19332	Personal Attribute		A street name is the token given to identify a particular street.
http://purl.obolibrary.org/obo/SCDO_1000872	SickleInAfrica CDE - Street Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the name of the street in which the respondent lives.
http://purl.obolibrary.org/obo/SCDO_1000873	SickleInAfrica CDE - Nearest Landmark Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the landmark that is nearest to where the participant lives.
http://purl.obolibrary.org/obo/SCDO_1000874	Nearest Geographical Landmark	http://purl.obolibrary.org/obo/NCIT_C19332	Personal Attribute		A recognizable natural or artificial geographic feature, used for navigation (often visible from long distances), that is nearest to where the participant lives.
http://purl.obolibrary.org/obo/SCDO_1000875	Next of Kin Name	http://purl.obolibrary.org/obo/NCIT_C25191	Person Name		The name of a respondent's next of kin.
http://purl.obolibrary.org/obo/SCDO_1000876	SickleInAfrica CDE - Telephone 1 Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the participant's primary telephone number.
http://purl.obolibrary.org/obo/SCDO_1000877	SickleInAfrica CDE - Telephone 2 Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the participant's secondary telephone number.
http://purl.obolibrary.org/obo/SCDO_1000878	SickleInAfrica CDE - Next of Kin Name Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the name of the participant's next of kin.
http://purl.obolibrary.org/obo/SCDO_1000879	SickleInAfrica CDE - Next of Kin Number Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the telephone number of the participant's next of kin.
http://purl.obolibrary.org/obo/SCDO_1000880	SickleInAfrica CDE - Relationship to Participant Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the participant's next of kin's relationship to the participant.
http://purl.obolibrary.org/obo/SCDO_1000882	Telephone Number 1	http://purl.obolibrary.org/obo/NCIT_C40978	Telephone Number		A respondent's primary telephone number.
http://purl.obolibrary.org/obo/SCDO_1000883	Telephone Number 2	http://purl.obolibrary.org/obo/NCIT_C40978	Telephone Number		A respondent's secondary telephone number.
http://purl.obolibrary.org/obo/SCDO_1000884	Next of Kin Telephone Number	http://purl.obolibrary.org/obo/NCIT_C40978	Telephone Number		The telephone number of a respondent's next of kin.
http://purl.obolibrary.org/obo/SCDO_1000885	Next of Kin Relationship to Participant	http://purl.obolibrary.org/obo/NCIT_C19332	Personal Attribute		The relationship that the participant's next of kin has with the participant.
http://purl.obolibrary.org/obo/SCDO_1000886	SickleInAfrica CDE - Blood Transfusion Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records whether the participant was given a blood transfusion.
http://purl.obolibrary.org/obo/SCDO_1000887	SickleInAfrica CDE - Units Transfused Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records the number of units of blood that a participant was given during a blood transfusion.
http://purl.obolibrary.org/obo/SCDO_1000888	Number of Units Transfused	http://purl.obolibrary.org/obo/SCDO_1000590	SCD Management Details		The number of units of blood that a patient received during a blood transfusion.
http://purl.obolibrary.org/obo/SCDO_1000889	SickleInAfrica CDE - Difficulty in Breathing Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records whether a participant has difficulty in breathing.
http://purl.obolibrary.org/obo/SCDO_1000890	SickleInAfrica CDE - Systolic Blood Pressure Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records a participant's systolic blood pressure.
http://purl.obolibrary.org/obo/SCDO_1000891	SickleInAfrica CDE - Diastolic Blood Pressure Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records a participant's diastolic blood pressure.
http://purl.obolibrary.org/obo/SCDO_1000894	SickleInAfrica CDE - Priapism Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records whether a participant has priapism.
http://purl.obolibrary.org/obo/SCDO_1000895	SickleInAfrica CDE - Chest Pain Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records whether a participant has chest pain.
http://purl.obolibrary.org/obo/SCDO_1000896	SickleInAfrica CDE - Anaemia Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records whether a participant has anaemia.
http://purl.obolibrary.org/obo/SCDO_1000897	SickleInAfrica CDE - Jaundice Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that records whether a participant has jaundice.
http://purl.obolibrary.org/obo/SCDO_1000898	SickleInAfrica CDE - Urea Question	http://purl.obolibrary.org/obo/SCDO_1000509	SickleInAfrica Core Data Element		The Sickle in Africa core data element that collects the concentration of urea in the respondent's blood.
http://purl.obolibrary.org/obo/SCDO_1000900	First Visit	http://purl.obolibrary.org/obo/NCIT_C103165	Subject Visit Type		A clinical visit that is the patient's first clinical visit.
http://purl.obolibrary.org/obo/SCDO_1000901	Follow-Up Visit	http://purl.obolibrary.org/obo/NCIT_C103165	Subject Visit Type		A clinical visit that is a follow-up for a previous visit.
http://purl.obolibrary.org/obo/CHEBI_35482	Opioid	http://purl.obolibrary.org/obo/SCDO_0000050	Analgesic		A narcotic or opioid substance, synthetic or semisynthetic agent producing profound analgesia, drowsiness, and changes in mood.
http://purl.obolibrary.org/obo/CHEBI_60809	Adjuvant	http://purl.obolibrary.org/obo/SCDO_0001152	Therapeutics		Any pharmacological or immunological agent that modifies the effect of other agents such as drugs or vaccines while having few if any direct effects when given by itself.
http://purl.obolibrary.org/obo/CHEBI_23888	Drug	http://purl.obolibrary.org/obo/SCDO_0001152	Therapeutics		Any substance which when absorbed into a living organism may modify one or more of its functions. The term is generally accepted for a substance taken for a therapeutic purpose, but is also commonly used for abused substances.
http://purl.obolibrary.org/obo/CHEBI_42797	Gabapentin	http://purl.obolibrary.org/obo/CHEBI_23888	Drug		A gamma-amino acid that is cyclohexane substituted at position 1 by aminomethyl and carboxymethyl groups. Used for treatment of neuropathic pain and restless legs syndrome.
http://purl.obolibrary.org/obo/CHEBI_6909	Metronidazole	http://purl.obolibrary.org/obo/NCIT_C258	Antibiotic		A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
http://purl.obolibrary.org/obo/CHEBI_7852	Oxycodone	http://purl.obolibrary.org/obo/CHEBI_35482	Opioid		A semisynthetic derivative of codeine that acts as a narcotic analgesic more potent and addicting than codeine.
http://purl.obolibrary.org/obo/DOID_0050731	Vitamin B12 Deficiency	http://purl.obolibrary.org/obo/SCDO_1000261	Avitaminosis		A vitamin metabolic disorder that results from low blood levels of vitamin B12.
http://purl.obolibrary.org/obo/DOID_0060181	Ischemic Cholitis	http://purl.obolibrary.org/obo/HP_0025031	Abnormality of the Digestive System		A colitis caused by inadequate blood supply to the colon.
http://purl.obolibrary.org/obo/DOID_1188	Mononeuropathy	http://purl.obolibrary.org/obo/HP_0012639	Abnormal Nervous System Morphology		A neuropathy that is characterized by damage to a single nerve, which results in loss of movement, sensation, or other function of that nerve.
http://purl.obolibrary.org/obo/DOID_1584	Acute Chest Syndrome	http://purl.obolibrary.org/obo/SCDO_1000000	Acute Phenotype		A lung disease that involves a vasoocclusive crisis of the pulmonary vasculature seen in patients with sickle cell anemia. The crisis is initiated by a lung infection, and the resulting inflammation and loss of oxygen tension leads to sickling of red cells and further vasoocclusion.
http://purl.obolibrary.org/obo/DOID_1826	Epilepsy	http://purl.obolibrary.org/obo/HP_0000708	Behavioural Abnormality		A brain disease that is characterized by the occurrance of at least two unprovoked seizures resulting from a persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity and typically manifested by sudden brief episodes of altered or diminished consciousness, involuntary movements, or convulsions.
http://purl.obolibrary.org/obo/DOID_4	Disease	http://purl.obolibrary.org/obo/SCDO_0001000	SCDO		A disease is a disposition (i) to undergo pathological processes that (ii) exists in an organism because of one or more disorders in that organism.
http://purl.obolibrary.org/obo/HP_0000132	Menorrhagia	http://purl.obolibrary.org/obo/HP_0012243	Abnormal Reproductive System Morphology		Prolonged and/or excessive menses at regular intervals in excess of 80 ml or lasting longer than 7 days.
http://purl.obolibrary.org/obo/HP_0000271	Abnormality of the Face	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		An abnormality of the face.
http://purl.obolibrary.org/obo/HP_0000618	Blindness	http://purl.obolibrary.org/obo/HP_0000505	Visual Impairment		Blindness is the condition of lacking visual perception defined as visual perception below 3/60 and/or a visual field of no greater than 10 degress in radius around central fixation.
http://purl.obolibrary.org/obo/HP_0000707	Abnormality of the Nervous System	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		Any abnormality of the nervous system.
http://purl.obolibrary.org/obo/HP_0000819	Diabetes Mellitus	http://purl.obolibrary.org/obo/SCDO_0000267	Comorbid Disease		A group of abnormalities characterized by hyperglycemia and glucose intolerance.
http://purl.obolibrary.org/obo/HP_0000924	Abnormality of the Skeletal System	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		An abnormality of the skeletal system.
http://purl.obolibrary.org/obo/HP_0000952	Jaundice	http://purl.obolibrary.org/obo/SCDO_0000954	Quality of Life Related SCD Symptoms and Complications		Yellow pigmentation of the skin or sclera due to bilirubin, which in turn is the result of increased bilirubin concentration in the bloodstream.
http://purl.obolibrary.org/obo/HP_0000962	Hyperkeratosis	http://purl.obolibrary.org/obo/HP_0011121	Abnormality of Skin Morphology		Hyperkeratosis is thickening of the outer layer of the skin, the stratum corneum, which is composed of large, polyhedral, plate-like envelopes filled with keratin which are the dead cells that have migrated up from the stratum granulosum.
http://purl.obolibrary.org/obo/HP_0000967	Petechiae	http://purl.obolibrary.org/obo/HP_0002597	Abnormality of the Vasculature		Petechiae are pinpoint-sized reddish/purple spots, resembling a rash, that appear just under the skin or a mucous membrane when capillaries have ruptured and some superficial bleeding into the skin has happened. This term refers to an abnormally increased susceptibility to developing petechiae.
http://purl.obolibrary.org/obo/HP_0000969	Edema	http://purl.obolibrary.org/obo/SCDO_0002674	Abnormality of Metabolism/Homeostasis		An abnormal accumulation of fluid beneath the skin, or in one or more cavities of the body.
http://purl.obolibrary.org/obo/HP_0000999	Pyoderma	http://purl.obolibrary.org/obo/HP_0011122	Abnormality of Skin Physiology		Any manifestation of a skin disease associated with the production of pus.
http://purl.obolibrary.org/obo/HP_0001022	Albinism	http://purl.obolibrary.org/obo/HP_0001010	Hypopigmentation		An abnormal reduction in the amount of pigmentation (reduced or absent) of skin, hair and eye (iris and retina).
http://purl.obolibrary.org/obo/HP_0001025	Urticaria	http://purl.obolibrary.org/obo/HP_0002597	Abnormality of the Vasculature		Raised, well-circumscribed areas of erythema and edema involving the dermis and epidermis. Urticaria is intensely pruritic, and blanches completely with pressure.
http://purl.obolibrary.org/obo/HP_0001250	Seizure	http://purl.obolibrary.org/obo/HP_0012638	Abnormal Nervous System Physiology		Seizures are an intermittent abnormality of the central nervous system due to a sudden, excessive, disorderly discharge of cerebral neurons and characterized clinically by some combination of disturbance of sensation, loss of consciousness, impairment of psychic function, or convulsive movements. The term epilepsy is used to describe chronic, recurrent seizures.
http://purl.obolibrary.org/obo/HP_0001254	Lethargy	http://purl.obolibrary.org/obo/HP_0012638	Abnormal Nervous System Physiology		A state of disinterestedness, listlessness, and indifference, resulting in difficulty performing simple tasks or concentrating.
http://purl.obolibrary.org/obo/HP_0001260	Dysarthria	http://purl.obolibrary.org/obo/HP_0012638	Abnormal Nervous System Physiology		Dysarthric speech is a general description referring to a neurological speech disorder characterized by poor articulation. Depending on the involved neurological structures, dysarthria may be further classified as spastic, flaccid, ataxic, hyperkinetic and hypokinetic, or mixed.
http://purl.obolibrary.org/obo/HP_0001269	Hemiparesis	http://purl.obolibrary.org/obo/HP_0012638	Abnormal Nervous System Physiology		Loss of strength in the arm, leg, and sometimes face on one side of the body. Hemiplegia refers to a complete loss of strength, whereas hemiparesis refers to an incomplete loss of strength.
http://purl.obolibrary.org/obo/HP_0001287	Meningitis	http://purl.obolibrary.org/obo/IDO_0000586	Infection		Inflammation of the meninges.
http://purl.obolibrary.org/obo/HP_0001289	Confusion	http://purl.obolibrary.org/obo/HP_0012638	Abnormal Nervous System Physiology		Lack of clarity and coherence of thought, perception, understanding, or action.
http://purl.obolibrary.org/obo/HP_0001369	Arthritis	http://purl.obolibrary.org/obo/HP_0000924	Abnormality of the Skeletal System		Inflammation of a joint.
http://purl.obolibrary.org/obo/HP_0001370	Rheumatoid Arthritis	http://purl.obolibrary.org/obo/HP_0001369	Arthritis		An autoimmune response that primarily affects connective tissue; it also results in chronic inflammation of the joints, especially of the hands and feet and may also cause inflammation of the tissue around the joints, as well as other organs in the body.
http://purl.obolibrary.org/obo/HP_0001433	Hepatosplenomegaly	http://purl.obolibrary.org/obo/HP_0001743	Abnormality of the Spleen		Simultaneous enlargement of the liver and spleen.
http://purl.obolibrary.org/obo/HP_0001508	Failure to Thrive	http://purl.obolibrary.org/obo/HP_0001507	Growth Abnormality		Failure to thrive (FTT) refers to a child whose physical growth is substantially below the norm.
http://purl.obolibrary.org/obo/HP_0001513	Obesity	http://purl.obolibrary.org/obo/HP_0001507	Growth Abnormality		Body weight that is grossly above the acceptable or desirable weight, usually due to accumulation of excess fats in the body. The standards may vary with age, sex, genetic or cultural background. In the body mass index (BMI), a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese.
http://purl.obolibrary.org/obo/HP_0001744	Splenomegaly	http://purl.obolibrary.org/obo/HP_0001743	Abnormality of the Spleen		Abnormal increased size of the spleen.
http://purl.obolibrary.org/obo/HP_0001789	Hydrops Fetalis	http://purl.obolibrary.org/obo/HP_0000969	Edema		The abnormal accumulation of fluid in two or more fetal compartments, including ascites, pleural effusion, pericardial effusion, and skin edema.
http://purl.obolibrary.org/obo/HP_0001873	Thrombocytopenia	http://purl.obolibrary.org/obo/HP_0011873	Abnormal Platelet Count		A reduction in the number of circulating thrombocytes.
http://purl.obolibrary.org/obo/HP_0001882	Leukopenia	http://purl.obolibrary.org/obo/HP_0011893	Abnormal Leukocyte Count		An abnormal decreased number of leukocytes in the blood.
http://purl.obolibrary.org/obo/HP_0001889	Megaloblastic Anemia	http://purl.obolibrary.org/obo/HP_0001903	Anemia		Anemia characterized by the presence of erythroblasts that are larger than normal (megaloblasts).
http://purl.obolibrary.org/obo/HP_0001903	Anemia	http://purl.obolibrary.org/obo/HP_0001877	Abnormal Erythrocyte Morphology		A reduction in erythrocytes volume or hemoglobin concentration.
http://purl.obolibrary.org/obo/HP_0001974	Leukocytosis	http://purl.obolibrary.org/obo/HP_0011893	Abnormal Leukocyte Count		An abnormal increase in the number of leukocytes in the blood.
http://purl.obolibrary.org/obo/HP_0001977	Abnormal Thrombosis	http://purl.obolibrary.org/obo/HP_0001871	Abnormality of Blood and Blood-Forming Tissues		Venous or arterial thrombosis (formation of blood clots) of spontaneous nature and which cannot be fully explained by acquired risk (e.g. atherosclerosis).
http://purl.obolibrary.org/obo/HP_0002090	Pneumonia	http://purl.obolibrary.org/obo/HP_0002715	Abnormality of the Immune System		Inflammation of any part of the lung parenchyma.
http://purl.obolibrary.org/obo/HP_0002098	Respiratory Distress	http://purl.obolibrary.org/obo/HP_0002086	Abnormality of the Respiratory System		Difficulty in breathing. The physical presentation of respiratory distress is generally referred to as labored breathing, while the sensation of respiratory distress is called shortness of breath or dyspnea.
http://purl.obolibrary.org/obo/HP_0002149	Hyperuricemia	http://purl.obolibrary.org/obo/HP_0002157	Azotaemia		An abnormally high level of uric acid in the blood.
http://purl.obolibrary.org/obo/HP_0002164	Nail Dysplasia	http://purl.obolibrary.org/obo/HP_0001574	Abnormality of the Integument		The presence of developmental dysplasia of the nail.
http://purl.obolibrary.org/obo/HP_0002204	Pulmonary Embolism	http://purl.obolibrary.org/obo/HP_0030680	Abnormal Cardiovascular System Morphology		An embolus (that is, an abnormal particle circulating in the blood) located in the pulmonary artery and thereby blocking blood circulation to the lung. Usually the embolus is a blood clot that has developed in an extremity (for instance, a deep venous thrombosis), detached, and traveled through the circulation before becoming trapped in the pulmonary artery.
http://purl.obolibrary.org/obo/HP_0002650	Scoliosis	http://purl.obolibrary.org/obo/HP_0000924	Abnormality of the Skeletal System		The presence of an abnormal lateral curvature of the spine.
http://purl.obolibrary.org/obo/HP_0002653	Bone Pain	http://purl.obolibrary.org/obo/SCDO_0000851	Pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to bone.
http://purl.obolibrary.org/obo/HP_0002725	Systemic Lupus Erythematosus	http://purl.obolibrary.org/obo/SCDO_0000267	Comorbid Disease		A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes.
http://purl.obolibrary.org/obo/HP_0002829	Arthralgia	http://purl.obolibrary.org/obo/SCDO_0000851	Pain		Joint pain.
http://purl.obolibrary.org/obo/HP_0003418	Back Pain	http://purl.obolibrary.org/obo/SCDO_0000851	Pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the back.
http://purl.obolibrary.org/obo/HP_0003470	Paralysis	http://purl.obolibrary.org/obo/HP_0012638	Abnormal Nervous System Physiology		Paralysis of voluntary muscles means loss of contraction due to interruption of one or more motor pathways from the brain to the muscle fibers. Motor paralysis is often accompanied by an impairment in the facility of movement.
http://purl.obolibrary.org/obo/HP_0010885	Osteonecrosis	http://purl.obolibrary.org/obo/HP_0000924	Abnormality of the Skeletal System		A disease where there is cellular death (necrosis) of bone components due to interruption of the blood supply.
http://purl.obolibrary.org/obo/HP_0011001	Increased Bone Mineral Density	http://purl.obolibrary.org/obo/HP_0000924	Abnormality of the Skeletal System		An abnormal increase of bone mineral density, that is, of the amount of matter per cubic centimeter of bones which is often refered to as osteosclerosis. Osteosclerosis can be detected on radiological examination as an increased whiteness (density) of affected bones.
http://purl.obolibrary.org/obo/HP_0011123	Skin Inflammation	http://purl.obolibrary.org/obo/HP_0011122	Abnormality of Skin Physiology		The presence of inflammation of the skin. That is, an abnormality of the skin resulting from the local accumulation of fluid, plasma proteins, and leukocytes.
http://purl.obolibrary.org/obo/HP_0100614	Myositis	http://purl.obolibrary.org/obo/SCDO_1000268	Abnormality of the Musculature		A general term for inflammation of the muscles without respect to the underlying cause.
http://purl.obolibrary.org/obo/HP_0100774	Hyperostosis	http://purl.obolibrary.org/obo/HP_0000924	Abnormality of the Skeletal System		Excessive growth or abnormal thickening of bone tissue.
http://purl.obolibrary.org/obo/HP_0100806	Sepsis	http://purl.obolibrary.org/obo/IDO_0000586	Infection		Severe systemic inflammatory response to infection.
http://purl.obolibrary.org/obo/ExO_0000048	Built Environment	http://purl.obolibrary.org/obo/SCDO_0000897	Physical Environment		Human-made surroundings that provide the setting for human activity, ranging in scale from personal shelter and buildings to neighborhoods and cite, and can often include their supporting infrastructure, such as water supply or energy networks.
http://purl.obolibrary.org/obo/NCIT_C26702	Ataxia	http://purl.obolibrary.org/obo/HP_0012638	Abnormal Nervous System Physiology		Lack of coordination of muscle movements resulting in the impairment or inability to perform voluntary activities. Causes include peripheral nerve disorders, posterior column injuries, cerebral and cerebellar disorders, basal ganglia disorders, and thalamic disorders.
http://purl.obolibrary.org/obo/NCIT_C28407	National Origin	http://purl.obolibrary.org/obo/NCIT_C16495	Demographic Factor		System of classification based on nation from which a person originates, regardless of the nation in which he/she currently resides.
http://purl.obolibrary.org/obo/NCIT_C28516	Sickle Cell Dactylitis	http://purl.obolibrary.org/obo/SCDO_0001023	SCD Related Pain		A severe acute inflammatory response affecting the hands and feet of individuals with sickle cell disease, sickle cell-hemoglobin C disease or sickle cell-beta-thalassemia. It is caused by vaso-occlusive episodes leading to ischemia and finally infarction of the distal portions of the extremities. Clinical signs of pain, swelling and tenderness of digits usually begin in early childhood and may be the initial manifestations of sickle cell anemia. Clinical course is self-limited with instances typically lasting a few weeks and occurring during sickling crises. An initial episode before the age of 1 strongly correlates with a more severe disease course.
http://purl.obolibrary.org/obo/SCDO_1000408	Data Use Requirements	http://purl.obolibrary.org/obo/SCDO_0006339	Research		Requirements indicate additional conditions set for use of data.
http://purl.obolibrary.org/obo/CHEBI_35475	Non-Steroidal Anti-Inflammatory Drug	http://purl.obolibrary.org/obo/SCDO_0000057	Anti-Inflammatory Agent		An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
http://purl.obolibrary.org/obo/HP_0004727	Impaired Renal Concentrating Ability	http://purl.obolibrary.org/obo/HP_0000077	Abnormality of the Kidney		A defect in the ability to concentrate the urine.
http://purl.obolibrary.org/obo/HP_0004756	Ventricular Tachycardia	http://purl.obolibrary.org/obo/SCDO_0001851	Tachycardia		A tachycardia originating in the ventricles characterized by rapid heart rate (over 100 beats per minute) and broad QRS complexes (over 120 ms).
http://purl.obolibrary.org/obo/HP_0004825	Increased Hemoglobin Oxygen Affinity	http://purl.obolibrary.org/obo/HP_0020054	Abnormal Erythrocyte Physiology		An abnormal increase in the binding affinity of hemoglobin for oxygen.
http://purl.obolibrary.org/obo/HP_0004870	Chronic Hemolytic Anemia	http://purl.obolibrary.org/obo/SCDO_0005167	Chronic Anemia		A chronic form of hemolytic anemia.
http://purl.obolibrary.org/obo/HP_0005162	Left Ventricular Dysfunction	http://purl.obolibrary.org/obo/HP_0011025	Abnormal Cardiovascular System Physiology		Inability of the left ventricle to perform its normal physiologic function. Failure is either due to an inability to contract the left ventricle or the inability to relax completely and fill with blood during diastole.
http://purl.obolibrary.org/obo/HP_0005268	Spontaneous Abortion	http://purl.obolibrary.org/obo/NCIT_C34941	Pregnancy Complication		A pregnancy that ends at a stage in which the fetus is incapable of surviving on its own, defined as the spontaneous loss of a fetus before the 20th week of pregnancy.
http://purl.obolibrary.org/obo/HP_0005305	Cerebral Venous Thrombosis	http://purl.obolibrary.org/obo/HP_0001977	Abnormal Thrombosis		Formation of a blood clot (thrombus) inside a cerebral vein, causing the obstruction of blood flow.
http://purl.obolibrary.org/obo/HP_0005318	Cerebral Vasculitis	http://purl.obolibrary.org/obo/HP_0002060	Abnormality of the Cerebrum		Inflammation of the blood vessels within the brain.
http://purl.obolibrary.org/obo/HP_0005518	Increased Mean Corpuscular Volume	http://purl.obolibrary.org/obo/HP_0025065	Abnormal Mean Corpuscular Volume		Larger than normal size of erythrocytes. Macrocytosis refers to a mean cell volume (MCV) greater than 100 fL. If macrocytosis is an isolated abnormality, the amount of hemoglobin in the cell increases proportionately, so the mean cell hemoglobin concentration (MCHC) remains within normal limits.
http://purl.obolibrary.org/obo/HP_0005560	Imbalanced Hemoglobin Synthesis	http://purl.obolibrary.org/obo/SCDO_1000060	SCD Molecular Phenotype		Normal hemoglobin synthesis is characterized by production of equal amounts of alpha and beta globins. This term refers to a deviation from this pattern and is the main characteristic of the various forms of thalassemia.
http://purl.obolibrary.org/obo/HP_0006689	Bacterial Endocarditis	http://purl.obolibrary.org/obo/NCIT_C2890	Bacterial Infection		A bacterial infection of the endocardium, the inner layer of the heart, which usually involves the heart valves.
http://purl.obolibrary.org/obo/HP_0007018	Attention Deficit Hyperactivity Disorder	http://purl.obolibrary.org/obo/HP_0000708	Behavioural Abnormality		Attention deficit hyperactivity disorder (ADHD) manifests at age 2-3 years or by first grade at the latest. The main symptoms are distractibility, impulsivity, hyperactivity, and often trouble organizing tasks and projects, difficulty going to sleep, and social problems from being aggressive, loud, or impatient.
http://purl.obolibrary.org/obo/HP_0007340	Leg Weakness	http://purl.obolibrary.org/obo/HP_0025142	Constitutional Symptom		Weakness of the muscles of the legs.
http://purl.obolibrary.org/obo/HP_0007902	Vitreous Hemorrhage	http://purl.obolibrary.org/obo/HP_0000478	Abnormality of the Eye		Bleeding within the vitreous compartment of the eye.
http://purl.obolibrary.org/obo/HP_0008245	Secondary Hypothyroidism	http://purl.obolibrary.org/obo/HP_0000821	Hypothyroidism		A type of hypothyroidism that results from a defect in thyroid-stimulating hormone secretion.
http://purl.obolibrary.org/obo/HP_0008682	Acute Tubular Necrosis	http://purl.obolibrary.org/obo/SCDO_1000000	Acute Phenotype		Acute death of renal tubular cells that usually results from prolonged renal ischemia, nephrotoxins, or sepsis.
http://purl.obolibrary.org/obo/HP_0009045	Exercise-Induced Rhabdomyolysis	http://purl.obolibrary.org/obo/SCDO_1000260	Symptom Induced by Strenuous Exercise		Rhabdomyolysis induced by exercise.
http://purl.obolibrary.org/obo/HP_0011106	Hypovolemia	http://purl.obolibrary.org/obo/HP_0011025	Abnormal Cardiovascular System Physiology		A decrease in the amount of intravascular fluid, particularly in the volume of the circulating blood.
http://purl.obolibrary.org/obo/HP_0011410	Caesarian Section	http://purl.obolibrary.org/obo/HP_0001787	Abnormal Delivery		Delivery of a fetus through surgical incisions made through the abdominal wall (laparotomy) and the uterine wall (hysterotomy).
http://purl.obolibrary.org/obo/HP_0011413	Shoulder Dystocia	http://purl.obolibrary.org/obo/HP_0001787	Abnormal Delivery		Shoulder dystocia occurs when the fetal anterior shoulder impacts against the maternal symphysis following delivery of the vertex.
http://purl.obolibrary.org/obo/HP_0011695	Cerebellar Hemorrhage	http://purl.obolibrary.org/obo/HP_0002170	Intracranial Hemorrhage		Hemorrhage into the parenchyma of the cerebellum.
http://purl.obolibrary.org/obo/HP_0011856	Pica	http://purl.obolibrary.org/obo/SCDO_0000954	Quality of Life Related SCD Symptoms and Complications		An appetite for and the persistent ingestion of non-food substances such as clay. In order to diagnose pica, this behavior must have persisted over a period of at least one month.
http://purl.obolibrary.org/obo/HP_0011868	Sciatica	http://purl.obolibrary.org/obo/HP_0003418	Back Pain		Pain in the lower back and hip radiating in the distribution of the sciatic nerve.
http://purl.obolibrary.org/obo/HP_0011886	Hyphema	http://purl.obolibrary.org/obo/HP_0011025	Abnormal Cardiovascular System Physiology		Bleeding in the anterior chamber of the eye.
http://purl.obolibrary.org/obo/HP_0011897	Neutrophilia	http://purl.obolibrary.org/obo/HP_0011991	Abnormal Neutrophil Count		Increased number of neutrophils circulating in blood.
http://purl.obolibrary.org/obo/HP_0011904	Increased Hemoglobin F	http://purl.obolibrary.org/obo/HP_0020063	Increased Hemoglobin Concentration		Hemoglobin F (HbF) contains two globin alpha chains and two globin gamma chains. It is the main form of hemoglobin in the fetus during the last seven months of intrauterine development and in the half year of postnatal life. In adults it normally makes up less than one percent of all hemoglobiin. This term refers to an increase in HbF above this limit. In beta thalassemia major, it may represent over 90 percent of all hemoglobin, and in beta thalassemia minor it may make up between 0.5 to 4 percent.
http://purl.obolibrary.org/obo/HP_0011906	Reduced Beta/Alpha Synthesis Ratio	http://purl.obolibrary.org/obo/HP_0005560	Imbalanced Hemoglobin Synthesis		A reduction in the ratio of production of beta globin to that of alpha globin. This is the major abnormality in the various forms of beta thalassemia.
http://purl.obolibrary.org/obo/HP_0011907	Reduced Alpha/Beta Synthesis Ratio	http://purl.obolibrary.org/obo/HP_0005560	Imbalanced Hemoglobin Synthesis		A reduction in the ratio of production of alpha globin to that of beta globin. This is the major abnormality in the various forms of alpha thalassemia.
http://purl.obolibrary.org/obo/HP_0011950	Bronchiolitis	http://purl.obolibrary.org/obo/HP_0002086	Abnormality of the Respiratory System		Inflammation of the bronchioles.
http://purl.obolibrary.org/obo/HP_0012101	Decreased Serum Creatinine	http://purl.obolibrary.org/obo/HP_0012100	Abnormal Circulating Creatinine Level		An abnormally reduced amount of creatinine in the blood.
http://purl.obolibrary.org/obo/HP_0012203	Onychomycosis	http://purl.obolibrary.org/obo/NCIT_C3245	Fungal Infection		A fungal infection of the toenails or fingernails that tends to cause the nails to thicken, discolor, disfigure, and split.
http://purl.obolibrary.org/obo/HP_0012229	Cerebrospinal Fluid Pleocytosis	http://purl.obolibrary.org/obo/HP_0002060	Abnormality of the Cerebrum		An increased white blood cell count in the cerebrospinal fluid.
http://purl.obolibrary.org/obo/HP_0012282	Morbilliform Rash	http://purl.obolibrary.org/obo/HP_0011122	Abnormality of Skin Physiology		An exanthema consisting of widespread pink-to-red macules (flat spots of 2-10 mm in diameter) or papules (red bumps) that blanch with pressure. The macules and papules may cluster and merge to form sheets over several days.
http://purl.obolibrary.org/obo/HP_0012330	Pyelonephritis	http://purl.obolibrary.org/obo/HP_0000123	Nephritis		An inflammation of the kidney involving the parenchyma of kidney, the renal pelvis and the kidney calices.
http://purl.obolibrary.org/obo/HP_0012379	Abnormal Enzyme/Coenzyme Activity	http://purl.obolibrary.org/obo/SCDO_0002674	Abnormality of Metabolism/Homeostasis		An altered ability of any enzyme or their cofactors to act as catalysts. This term includes changes due to altered levels of an enzyme.
http://purl.obolibrary.org/obo/HP_0012418	Hypoxemia	http://purl.obolibrary.org/obo/MP_0002329	Abnormal Blood Gas Level		An abnormally low level of blood oxygen.
http://purl.obolibrary.org/obo/HP_0012465	Elevated Hepatic Iron Concentration	http://purl.obolibrary.org/obo/HP_0001392	Abnormality of the Liver		An increased level of iron in liver tissues.
http://purl.obolibrary.org/obo/HP_0012532	Chronic Pain	http://purl.obolibrary.org/obo/SCDO_0001334	Chronic Phenotype		Persistent pain, usually defined as pain that has lasted longer than 3 to 6 months.
http://purl.obolibrary.org/obo/HP_0012574	Mesangial Hypercellularity	http://purl.obolibrary.org/obo/HP_0000077	Abnormality of the Kidney		Increased numbers of mesangial cells per glomerulus, defined as four or more nuclei in a peripheral mesangial segment.
http://purl.obolibrary.org/obo/HP_0012587	Macroscopic Hematuria	http://purl.obolibrary.org/obo/SCDO_0000508	Hematuria		Hematuria that is visible upon inspection of the urine.
http://purl.obolibrary.org/obo/HP_0012594	Low Level Albuminuria	http://purl.obolibrary.org/obo/SCDO_0000037	Albuminuria		The presence of mildly increased concentrations of albumin in the urine (in adults, 30-150 mg per day).
http://purl.obolibrary.org/obo/HP_0012735	Cough	http://purl.obolibrary.org/obo/HP_0002086	Abnormality of the Respiratory System		A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation.
http://purl.obolibrary.org/obo/HP_0100601	Eclampsia	http://purl.obolibrary.org/obo/NCIT_C34941	Pregnancy Complication		An acute and life-threatening complication of pregnancy, which is characterized by the appearance of tonic-clonic seizures, usually in a patient who had developed pre-eclampsia. Eclampsia includes seizures and coma that happen during pregnancy but are not due to preexisting or organic brain disorders.
http://purl.obolibrary.org/obo/HP_0100602	Preeclampsia	http://purl.obolibrary.org/obo/NCIT_C34941	Pregnancy Complication		Pregnancy-induced hypertension in association with significant amounts of protein in the urine.
http://purl.obolibrary.org/obo/HP_0100749	Chest Pain	http://purl.obolibrary.org/obo/SCDO_0000851	Pain		An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the chest.
http://purl.obolibrary.org/obo/HP_0100820	Glomerulopathy	http://purl.obolibrary.org/obo/HP_0000077	Abnormality of the Kidney		Inflammatory or noninflammatory diseases affecting the glomeruli of the nephron.
http://purl.obolibrary.org/obo/CMO_0000001	Cardiovascular Measurement	http://purl.obolibrary.org/obo/SCDO_0000728	Diagnostic Measurement		Any value resulting from the quantification of a morphological or physiological parameter pertaining to the heart and/or blood vessels.
http://purl.obolibrary.org/obo/CMO_0000003	Blood Pressure Measurement	http://purl.obolibrary.org/obo/CMO_0000001	Cardiovascular Measurement		Measurement of the pressure, or force per area, exerted by circulating blood against the walls of the blood vessels. The pressure is dependent on the energy of the heart action, elasticity of the vessel walls and volume and viscosity of the blood.
http://purl.obolibrary.org/obo/CMO_0000011	Whole Body Morphological Measurement	http://purl.obolibrary.org/obo/CMO_0000021	Body Morphological Measurement		Morphological measurement involving the entire body of an organism.
http://purl.obolibrary.org/obo/CMO_0000015	Body Temperature	http://purl.obolibrary.org/obo/SCDO_0000728	Diagnostic Measurement		The level of heat in an organism.
http://purl.obolibrary.org/obo/CMO_0000021	Body Morphological Measurement	http://purl.obolibrary.org/obo/SCDO_0000728	Diagnostic Measurement		Measurement of the structure or forms of the entire body or parts of the body of an organism.
http://purl.obolibrary.org/obo/CMO_0000023	Blood Chemistry Measurement	http://purl.obolibrary.org/obo/CMO_0000035	Blood Measurement		A quantification of a parameter of the chemical composition of blood.
http://purl.obolibrary.org/obo/CMO_0000025	Red Blood Cell Count	http://purl.obolibrary.org/obo/CMO_0001356	Red Blood Cell Measurement		The number of red blood cells in a specified volume of blood most commonly 1 cubic millimeter (i.e. 1 microliter) of peripheral venous blood.
http://purl.obolibrary.org/obo/CMO_0000027	White Blood Cell Count	http://purl.obolibrary.org/obo/CMO_0002341	White Blood Cell Measurement		The number of white blood cells in a specified volume of blood.
http://purl.obolibrary.org/obo/CMO_0000029	Platelet Count	http://purl.obolibrary.org/obo/CMO_0000921	Platelet Measurement		The number of platelets (thrombocytes) in a specified volume of blood, usually expressed as platelets per cubic millimeter of whole blood.
http://purl.obolibrary.org/obo/CMO_0000030	Blood Neutrophil Count	http://purl.obolibrary.org/obo/CMO_0000111	Blood Granulocyte Count		The number of granulocytes categorized as neutrophils in a specified volume of blood. A neutrophil is, or is in the process of becoming, a granular leucocyte having a nucleus with three to five lobes connected by threads of chromatin, cytoplasm containing very fine granules, and which is readily stainable with neutral dyes.
http://purl.obolibrary.org/obo/CMO_0000035	Blood Measurement	http://purl.obolibrary.org/obo/SCDO_0000728	Diagnostic Measurement		A measurement of the blood, it's contents, cells or other factors contained within the blood.
http://purl.obolibrary.org/obo/CMO_0000036	Blood Cell Measurement	http://purl.obolibrary.org/obo/CMO_0000035	Blood Measurement		A value resulting from the quantification of a morphological or physiological parameter of blood cells, i.e. cells native to the circulation, including those of erythroid, lymphoid, myeloid and monocytic lineages. A cell is a membrane-enclosed protoplasmic mass constituting the smallest structural unit of an organism that is capable of independent functioning.
http://purl.obolibrary.org/obo/CMO_0000037	Hematocrit	http://purl.obolibrary.org/obo/CMO_0001356	Red Blood Cell Measurement		Percentage of total blood volume that is made up of red blood cells.
http://purl.obolibrary.org/obo/CMO_0000038	Mean Corpuscular Volume	http://purl.obolibrary.org/obo/CMO_0001356	Red Blood Cell Measurement		A measure of the average volume or size of a single red blood cell. It is derived by dividing the total volume of packed red blood cells by the total red blood cell count.
http://purl.obolibrary.org/obo/CMO_0000057	Serum Creatinine Level	http://purl.obolibrary.org/obo/CMO_0000023	Blood Chemistry Measurement		The amount of creatinine, a catabolic product of creatine phosphate used in skeletal muscle contraction found in a specified volume of serum.
http://purl.obolibrary.org/obo/CMO_0000094	Respiratory System Measurement	http://purl.obolibrary.org/obo/SCDO_0000728	Diagnostic Measurement		A measurement to assess the morphological or physiological state of the respiratory system or portion of the respiratory system.
http://purl.obolibrary.org/obo/CMO_0000111	Blood Granulocyte Count	http://purl.obolibrary.org/obo/CMO_0000366	Blood Differential White Blood Cell Count		The number of granulocytes (polymorphonuclear leukocytes) in a specified volume of blood, usually 1 cubic millimeter.
http://purl.obolibrary.org/obo/CMO_0000123	Blood Bilirubin Level	http://purl.obolibrary.org/obo/CMO_0000023	Blood Chemistry Measurement		The amount of bilirubin found in a specific volume of blood.
http://purl.obolibrary.org/obo/CMO_0000195	Blood Flow Measurement	http://purl.obolibrary.org/obo/CMO_0000001	Cardiovascular Measurement		Any measurement of the movement of blood through the heart and blood vessels.
http://purl.obolibrary.org/obo/CMO_0000204	Blood Coagulation Measurement	http://purl.obolibrary.org/obo/CMO_0000035	Blood Measurement		Measurement to assess the sequential process through which multiple factors of the blood interact to form an insoluble fibrin clot.
http://purl.obolibrary.org/obo/CMO_0000210	Activated Partial Thromboplastin Time	http://purl.obolibrary.org/obo/CMO_0000204	Blood Coagulation Measurement		The time needed for plasma to form a fibrin clot after the addition of calcium and a phospholipid reagent. It is used to evaluate the intrinsic clotting system.
http://purl.obolibrary.org/obo/CMO_0000211	Prothrombin Time	http://purl.obolibrary.org/obo/CMO_0000204	Blood Coagulation Measurement		Measurement of the clotting ability of fibrinogen, prothrombin, proaccelerin, proconvertin and Stuart factor, usually given in seconds to formation of clot after the addition of a tissue factor or thromboplastin.
http://purl.obolibrary.org/obo/CMO_0000225	Arterial Blood Gas Measurement	http://purl.obolibrary.org/obo/CMO_0001321	Blood Gas Measurement		Any measurement of a gas or gases dissolved in arterial blood, that is, blood which has absorbed oxygen in the lungs, including oxygen, nitrogen carbon dioxide and/or hydrogen.
http://purl.obolibrary.org/obo/CMO_0000256	Urine Measurement	http://purl.obolibrary.org/obo/SCDO_0000728	Diagnostic Measurement		Any measurement of urine, the fluid waste product excreted by the kidneys, or its components.
http://purl.obolibrary.org/obo/CMO_0000283	Partial Pressure of Carbon Dioxide	http://purl.obolibrary.org/obo/CMO_0000225	Arterial Blood Gas Measurement		The force per unit area attributable to the carbon dioxide, a colorless, odorless, incombustible gas formed during respiration and composed of one atom of carbon and two atoms of oxygen, dissolved in a specified volume of blood, defined as the force per unit area exerted by carbon dioxide in a mixture of gases in equilibrium with such a sample of blood at the same temperature.
http://purl.obolibrary.org/obo/CMO_0000290	Mean Corpuscular Hemoglobin Level	http://purl.obolibrary.org/obo/CMO_0001356	Red Blood Cell Measurement		The average amount of hemoglobin per red blood cell calculated by dividing the total mass of hemoglobin by the number of red blood cells in a volume of blood.
http://purl.obolibrary.org/obo/CMO_0000291	Mean Corpuscular Hemoglobin Concentration	http://purl.obolibrary.org/obo/CMO_0001356	Red Blood Cell Measurement		The amount of hemoglobin in a given volume of packed red blood cells and is often calculated by dividing the hemoglobin concentration by the hematocrit.
http://purl.obolibrary.org/obo/CMO_0000364	Complete Blood Count	http://purl.obolibrary.org/obo/SCDO_0000133	Blood Test		The calculation of the cellular elements of the blood, usually including cell counts for white and red blood cells and platelets.
http://purl.obolibrary.org/obo/CMO_0000365	Total White Blood Cell Count	http://purl.obolibrary.org/obo/CMO_0000027	White Blood Cell Count		The total number of leukocytes in 1 cubic millimeter of peripheral venous blood.
http://purl.obolibrary.org/obo/CMO_0000366	Blood Differential White Blood Cell Count	http://purl.obolibrary.org/obo/CMO_0000027	White Blood Cell Count		The number of each type of leukocyte present in a specific volume of blood, usually 1 cubic millimeter.
http://purl.obolibrary.org/obo/CMO_0000376	Total Serum Bilirubin Level	http://purl.obolibrary.org/obo/CMO_0000123	Blood Bilirubin Level		The complete or entire amount of bilirubin in a specified volume of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed. Bilirubin is the bile pigment produced by breakdown of heme and reduction of biliverdin.
http://purl.obolibrary.org/obo/CMO_0000506	Hemoglobin Concentration	http://purl.obolibrary.org/obo/CMO_0000508	Hemoglobin Measurement		The amount of hemoglobin, the red oxygen-carrying pigment of erythrocytes, in a specified volume of blood, as calculated from the optical density of a solution of lysed red cells in which hemoglobin has been converted to cyanomethemoglobin and measured with a spectrophotometer.
http://purl.obolibrary.org/obo/CMO_0000507	Hemoglobin Absorbance	http://purl.obolibrary.org/obo/CMO_0000508	Hemoglobin Measurement		The optical density as calculated from the intensity of light at a specified wavelength as it passes through a solution of lysed red blood cells.
http://purl.obolibrary.org/obo/CMO_0000508	Hemoglobin Measurement	http://purl.obolibrary.org/obo/CMO_0000036	Blood Cell Measurement		A measure of the oxygen carrying pigment of erythrocytes.
http://purl.obolibrary.org/obo/CMO_0000665	Heart Contraction Pressure	http://purl.obolibrary.org/obo/SCDO_1000317	Heart Measurement		Pressure exerted by the heart muscle in its maximally contracted state.
http://purl.obolibrary.org/obo/CMO_0000921	Platelet Measurement	http://purl.obolibrary.org/obo/CMO_0000036	Blood Cell Measurement		Any measurement of platelets, the disk-shaped structures found in the blood of mammals which play a vital role in blood coagulation. Platelets lack nuclei and DNA but contain active enzymes and mitochondria.
http://purl.obolibrary.org/obo/CMO_0001321	Blood Gas Measurement	http://purl.obolibrary.org/obo/CMO_0000035	Blood Measurement		Any measurement of a gas or gases dissolved in the blood, including oxygen, nitrogen carbon dioxide and/or hydrogen.
http://purl.obolibrary.org/obo/CMO_0001324	Oxygen Saturation	http://purl.obolibrary.org/obo/CMO_0001321	Blood Gas Measurement		The amount of oxygen bound to hemoglobin in the blood expressed as a percentage of the maximal binding capacity.
http://purl.obolibrary.org/obo/CMO_0001356	Red Blood Cell Measurement	http://purl.obolibrary.org/obo/CMO_0000036	Blood Cell Measurement		Any measurement of a single red blood cell, one of the hemoglobin-containing blood cells that transport oxygen and carbon dioxide to and from the tissues, or of all of the red blood cells in a sample of blood.
http://purl.obolibrary.org/obo/CMO_0002079	Birth Weight	http://purl.obolibrary.org/obo/SCDO_0000152	Body Weight		The heaviness or degree to which the entire body of an organism at the point of or shortly after birth is drawn to the earth by gravity.
http://purl.obolibrary.org/obo/CMO_0002341	White Blood Cell Measurement	http://purl.obolibrary.org/obo/CMO_0000036	Blood Cell Measurement		Any value resulting from the quantification of a morphological or physiological parameter of leukocytes, largely colorless blood corpuscles capable of ameboid movement, whose chief function is to protect the body against microorganisms and other disease-causing entities.
http://purl.obolibrary.org/obo/CMO_0002520	Serum Haptoglobin Level	http://purl.obolibrary.org/obo/CMO_0000023	Blood Chemistry Measurement		Measurement of the amount of haptoglobin in a specified sample of serum, the clear liquid that separates from blood after it has clotted completely, i.e. blood plasma from which fibrinogen has been removed. Haptoglobin is a serum alpha2 globulin glycoprotein, produced by the liver, that functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin.
http://purl.obolibrary.org/obo/UO_0000000	Unit of Measurement	http://purl.obolibrary.org/obo/SCDO_1000472	Data Standards		A standardized quantity of a physical quality.
http://purl.obolibrary.org/obo/UO_0000190	Ratio	http://purl.obolibrary.org/obo/UO_0000186	Dimensionless Unit		A dimensionless unit which denotes an amount or magnitude of one quantity relative to another.
http://purl.obolibrary.org/obo/HsapDv_0000000	Human Life Cycle Stage	http://purl.obolibrary.org/obo/NCIT_C43646	Association		A spatiotemporal region encompassing some part of the life cycle of an organism.
http://purl.obolibrary.org/obo/HP_0012759	Neurodevelopmental Abnormality	http://purl.obolibrary.org/obo/HP_0012638	Abnormal Nervous System Physiology		A deviation from normal of the neurological development of a child, which may include any or all of the aspects of the development of personal, social, gross or fine motor, and cognitive abilities. This term should be used to describe abnormalities with onset in the developmental period.
http://purl.obolibrary.org/obo/HP_0025031	Abnormality of the Digestive System	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		Any anomaly of the digestive system, a collection of organs that is made up of the gastrointestinal tract and the liver, pancreas, and gallbladder. The gastrointestinal tract is a series of hollow organs joined in a long, twisting tube from the mouth to the anus, including the mouth, esophagus, stomach, small intestine, large intestine and anus.
http://purl.obolibrary.org/obo/HP_0030680	Abnormal Cardiovascular System Morphology	http://purl.obolibrary.org/obo/HP_0001626	Abnormality of Cardiovascular System		Any structural anomaly of the heart and great vessels.
http://purl.obolibrary.org/obo/STATO_0000091	Genome Wide Association Study	http://purl.obolibrary.org/obo/SCDO_0000437	Epidemiologic Studies		Genome wide association study is a kind of study whose objective is to detect association between genetic markers (SNP or otherwise) accross the genome and a trait which may be a disease or another phenotype (e.g. trait of agronomic relevance in animal or plant studies). Genome wide association study compare the allele frequencies in 2 populations, one free of the trait used as control, the other one showing the trait use as 'case'. GWAS studies implement case-control design.
http://purl.obolibrary.org/obo/NCIT_C103526	Patient Health Questionnaire-9 (PHQ-9)	http://purl.obolibrary.org/obo/SCDO_1000297	Quality of Life and Care Diagnostic Instrument		A 9-item scale using each of the 9 DSM-IV criteria with self-reported frequency of "0" (not at all) to "3" (nearly every day). One of the most widely used instruments to assess depression, PHQ-9 scores of 5, 10, 15, and 20 represent mild, moderate, moderately severe, and severe depression, respectively.
http://purl.obolibrary.org/obo/NCIT_C107564	S-Nitroso-Hemoglobin	http://purl.obolibrary.org/obo/NCIT_C16676	Hemoglobin		Hemoglobin that has a nitric oxide bound to the cysteine at position 93 in the beta-globin chain.
http://purl.obolibrary.org/obo/NCIT_C16676	Hemoglobin	http://purl.obolibrary.org/obo/NCIT_C26548	Gene Product		The red respiratory protein of erythrocytes, consisting of approximately 3.8% heme and 96.2% globin (64.5 KD), which as oxyhemoglobin (HbO2) transports oxygen from the lungs to the tissues where the oxygen is readily released and HbO2 becomes Hb.
http://purl.obolibrary.org/obo/NCIT_C25150	Age	http://purl.obolibrary.org/obo/NCIT_C16495	Demographic Factor		How long something has existed; elapsed time since birth.
http://purl.obolibrary.org/obo/NCIT_C118385	deprecated-Avascular Necrosis	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		Tissue death resulting from an interruption to the blood supply.
http://purl.obolibrary.org/obo/NCIT_C120254	Intelligence Scale - 16 to 90 years	http://purl.obolibrary.org/obo/NCIT_C122920	Intelligence Scale		A standardized tool designed to assess an individual's cognitive abilities. It consists of a battery of tests that allow an investigator to conduct a comprehensive cognitive evaluation of IQ.
http://purl.obolibrary.org/obo/NCIT_C120255	Intelligence Scale - 6 to 16 years 11 months	http://purl.obolibrary.org/obo/NCIT_C122920	Intelligence Scale		A battery of tests that allow an investigator to conduct a comprehensive evaluation of a child or adolescent's cognitive ability.
http://purl.obolibrary.org/obo/NCIT_C120256	Intelligence Scale - 2 years, 6 months to 7 years, 7 months	http://purl.obolibrary.org/obo/NCIT_C122920	Intelligence Scale		A standardized tool designed to assess the cognitive development in preschool and young children (up to age 7 years and 7 months). It consists of a battery of tests that allow an investigator to conduct a comprehensive evaluation of IQ.
http://purl.obolibrary.org/obo/NCIT_C16779	Language	http://purl.obolibrary.org/obo/SCDO_0001551	Ethnolinguistics		A systematic means of communicating by the use of sounds, symbols, or gestures.
http://purl.obolibrary.org/obo/NCIT_C25298	Systolic Blood Pressure	http://purl.obolibrary.org/obo/CMO_0000003	Blood Pressure Measurement		The maximum pressure exerted into the systemic arterial circulation during the contraction of the left ventricle of the heart.
http://purl.obolibrary.org/obo/NCIT_C25299	Diastolic Blood Pressure	http://purl.obolibrary.org/obo/CMO_0000003	Blood Pressure Measurement		The minimum pressure exerted into the systemic arterial circulation during cardiac ventricular relaxation and filling.
http://purl.obolibrary.org/obo/NCIT_C258	Antibiotic	http://purl.obolibrary.org/obo/CHEBI_23888	Drug		Substances naturally produced by microorganisms or their derivatives that selectively target microorganisms not humans. Antibiotics kill or inhibit the growth of microorganisms by targeting components of the microbial cell absent from human cells, including bacterial cell walls, cell membrane, and 30S or 50S ribosomal subunits. These substances are used in the treatment of bacterial and other microbial infections.
http://purl.obolibrary.org/obo/NCIT_C70731	Clinical Trial Subject Unique Identifier	http://purl.obolibrary.org/obo/NCIT_C69256	Subject Unique Identifier		A unique identifier assigned to each clinical trial subject to protect the subject's identity and used in lieu of the subject's name when the investigator reports adverse events and/or other trial-related data.
http://purl.obolibrary.org/obo/NCIT_C71375	Abdominal Ultrasound	http://purl.obolibrary.org/obo/NCIT_C17230	Ultrasound Test		A method of ultrasound imaging in which the ultrasound probe is pressed against the skin of the abdomen in order to create an image of the abdominal organs.
http://purl.obolibrary.org/obo/NCIT_C71754	Anonymous	http://purl.obolibrary.org/obo/SCDO_0002125	Confidentiality		Having no known name or identity or known source.
http://purl.obolibrary.org/obo/NCIT_C85397	Spirometry	http://purl.obolibrary.org/obo/SCDO_0000942	Pulmonary Function Test		Measurement of the breathing capacity of the lung by means of a spirometer.
http://purl.obolibrary.org/obo/NCIT_C86008	Methemoglobin	http://purl.obolibrary.org/obo/NCIT_C16676	Hemoglobin		A product of hemoglobin produced by oxidation of the iron atom from the ferrous to the ferric state.
http://purl.obolibrary.org/obo/NCIT_C92803	Genetic Screening	http://purl.obolibrary.org/obo/NCIT_C15709	Genetic Testing		Testing to determine if there is a predisposition or indication of a possible genetic or a chromosomal abnormality.
http://purl.obolibrary.org/obo/NCIT_C93407	Study Outcome Measurement	http://purl.obolibrary.org/obo/SCDO_0300005	Research Characteristics		Specific key measurement(s) or observation(s) used to measure the effect of experimental variables on the subjects in a study, or for observational studies, to describe patterns of diseases or traits or associations with exposures, risk factors or treatment. The specific measure that receives the most emphasis in assessment.
http://purl.obolibrary.org/obo/NCIT_C95437	Acute Pancreatitis	http://purl.obolibrary.org/obo/HP_0025031	Abnormality of the Digestive System		An acute inflammatory process that leads to necrosis of the pancreatic parenchyma. Signs and symptoms include severe abdominal pain, nausea, vomiting, diarrhea, fever, and shock. Causes include alcohol consumption, presence of gallstones, trauma, and drugs.
http://purl.obolibrary.org/obo/NCIT_C95504	Hemoglobin H Disease	http://purl.obolibrary.org/obo/SCDO_0000042	Alpha Thalassemia		A form of alpha thalassemia that results from reduced protein production from three of the four alpha-globin genes. Clinically it is characterized by chronic hemolytic anemia.
http://purl.obolibrary.org/obo/NCIT_C95535	Alpha Thalassemia Trait	http://purl.obolibrary.org/obo/SCDO_0000551	Thalassemia Trait		A condition in which a person has reduced protein production from two of the four alpha-globin alleles.
http://purl.obolibrary.org/obo/NCIT_C95536	Alpha Thalassemia Silent Carrier	http://purl.obolibrary.org/obo/SCDO_0000551	Thalassemia Trait		A condition in which a person has reduced protein production from one of the four alpha-globin alleles.
http://purl.obolibrary.org/obo/NCIT_C95539	Sickle Beta Thalassemia	http://purl.obolibrary.org/obo/SCDO_0007656	Sickle Cell Thalassemia		A compound heterozygous state in which a person has a hemoglobin S allele along with a beta-thalassemia allele. The severity of the condition is determined to a large extent by the quantity of normal hemoglobin produced by the beta-thalassemia gene.
http://purl.obolibrary.org/obo/NCIT_C142664	Recruitment Period	http://purl.obolibrary.org/obo/SCDO_0300005	Research Characteristics		The interval of time during which subjects are to be enrolled in a clinical study.
http://purl.obolibrary.org/obo/NCIT_C173396	Cerebral Blood Flow Velocity	http://purl.obolibrary.org/obo/SCDO_0000213	Cerebrovascular Hemodynamics		The rate of blood flow through the cerebral arteries.
http://purl.obolibrary.org/obo/SCDO_0000334	D57.819 Other sickle-cell disorders with crisis, unspecified	http://purl.obolibrary.org/obo/SCDO_0000331	D57.81 Other sickle-cell disorders with crisis		-
http://purl.obolibrary.org/obo/SCDO_0000765	Genetic Phenomena	http://purl.obolibrary.org/obo/SCDO_0001000	SCDO		The biological processes, properties, and objects that are involved in maintaining, expressing, and transmitting from one organism to another, genetically encoded traits.
http://purl.obolibrary.org/obo/CHEBI_5790	Hydromorphone	http://purl.obolibrary.org/obo/CHEBI_35482	Opioid		An opioid analgesic derived from morphine and used mainly as an analgesic. It has a shorter duration of action and is more potent than morphine.
http://purl.obolibrary.org/obo/NCIT_C128326	Intra-Abdominal Abscess	http://purl.obolibrary.org/obo/IDO_0000586	Infection		An abscess within the abdomen.
http://purl.obolibrary.org/obo/NCIT_C129072	Hereditary Persistence of Fetal Hemoglobin	http://purl.obolibrary.org/obo/SCDO_0007192	Quantitative Hemoglobinopathy		The persistence of substantial fetal hemoglobin production into adulthood, usually associated with hemoglobinopathies due to mutations in the alpha and/or beta chain of hemoglobin.
http://purl.obolibrary.org/obo/NCIT_C19771	Molecular Profiling Assay	http://purl.obolibrary.org/obo/SCDO_0000082	Diagnostic Technique, Method, Test or Assay		Analysis of the RNA expression pattern in a tissue sample using molecular techniques.
http://purl.obolibrary.org/obo/NCIT_C3245	Fungal Infection	http://purl.obolibrary.org/obo/IDO_0000586	Infection		An infection caused by a fungus.
http://purl.obolibrary.org/obo/EUPATH_0000034	Alpha Thalassemia Genotype	http://purl.obolibrary.org/obo/SCDO_0004061	Genotype		A genotype information which is about the presence and degree of alpha-thalassemia, a form of thalassemia involving the number of functional HBA1 and HBA2 genes.
http://purl.obolibrary.org/obo/EUPATH_0000050	Routine Clinical Visit	http://purl.obolibrary.org/obo/NCIT_C103165	Subject Visit Type		A clinical visit that is primarily for a regular examination.
http://purl.obolibrary.org/obo/EUPATH_0000215	Severe Anemia	http://purl.obolibrary.org/obo/HP_0001903	Anemia		An anemia with hemoglobin levels less than 5 gm/dL.
http://purl.obolibrary.org/obo/EUPATH_0000310	Information on Observation Details	http://purl.obolibrary.org/obo/SCDO_0006339	Research		An information content entity that is about a clinical visit.
http://purl.obolibrary.org/obo/ICO_0000179	Broad Consent	http://purl.obolibrary.org/obo/SCDO_0007087	Informed Consent		An informed consent for an unspecified range of future research subject to a few content and/or process restrictions.
http://purl.obolibrary.org/obo/SCDO_0000396	Doppler Ultrasound Machine - 2 Megahertz	http://purl.obolibrary.org/obo/OBI_0001098	Ultrasound Machine		A diagnostic ultrasound-based imaging technique operating at the frequency range of 2 megahertz. This machine makes use of the doppler effect to measure and visualise blood flow for possible pathology or lesions within blood vessels.
http://purl.obolibrary.org/obo/SCDO_1000228	Hemoglobin Genotype AO-Arab	http://purl.obolibrary.org/obo/SCDO_0004061	Genotype		A genotype whereby one HBB allele produces hemoglobin beta chains for normal adult hemoglobin and the other produces the abnormal hemoglobin beta chains for hemoglobin O-Arab. Individuals with this genotype are known to be carriers of the hemoglobin O-Arab trait.
http://purl.obolibrary.org/obo/SCDO_0000066	Antihistamine	http://purl.obolibrary.org/obo/CHEBI_23888	Drug		Drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. Classical antihistaminics block the histamine H1 receptors only.
http://purl.obolibrary.org/obo/MP_0011469	Abnormal Urine Creatinine Level	http://purl.obolibrary.org/obo/MP_0011468	Abnormal Urine Amino Acid Level		Any change in the amount of creatinine in the urine
http://purl.obolibrary.org/obo/MP_0011470	Increased Urine Creatinine Level	http://purl.obolibrary.org/obo/MP_0011469	Abnormal Urine Creatinine Level		An increased amount of creatinine in the urine compared to the normal state.
http://purl.obolibrary.org/obo/MP_0011471	Decreased Urine Creatinine Level	http://purl.obolibrary.org/obo/MP_0011469	Abnormal Urine Creatinine Level		a reduced amount of creatinine in the urine compared to the normal state
http://purl.obolibrary.org/obo/MP_0013305	Isosthenuria	http://purl.obolibrary.org/obo/HP_0004727	Impaired Renal Concentrating Ability		Inability of the kidneys to produce either a concentrated or a dilute urine; refers to a state in chronic renal disease in which the kidney cannot form urine with a higher or a lower specific gravity (concentration) than that of protein-free plasma; the specific gravity of the urine becomes fixed, irrespective of the fluid intake.
http://purl.obolibrary.org/obo/OGMS_0000028	Disease Phenotype	http://purl.obolibrary.org/obo/OGMS_0000023	Phenotype		A clinically abnormal phenotype that is characteristic of a single disease.
http://purl.obolibrary.org/obo/OGMS_0000046	Epigenetic Disorder	http://purl.obolibrary.org/obo/SCDO_0000444	Genetic Disease Modifier		A disorder whose etiology involves (1) a modification to the patient's genomic DNA which leads to alterations in the normal expression pattern of the genome, but is (2) not a change in the nucleotide sequence.
http://purl.obolibrary.org/obo/OGMS_0000047	Genetic Disorder	http://purl.obolibrary.org/obo/DOID_4	Disease		A disorder whose etiology involves an abnormality in the nucleotide sequence of an organism's genome.
http://purl.obolibrary.org/obo/OGMS_0000051	Constitutional Genetic Disorder	http://purl.obolibrary.org/obo/OGMS_0000047	Genetic Disorder		A genetic disorder inherited during conception that is part of all cells in the organism.
http://purl.obolibrary.org/obo/OGMS_0000088	Patient Symptom Report	http://purl.obolibrary.org/obo/SCDO_0000738	Medical Records		A communication from a patient about something they perceive as being abnormal about their body or life.
http://purl.obolibrary.org/obo/IDOMAL_0000592	Spleen Examination	http://purl.obolibrary.org/obo/SCDO_0000898	Physical Examination		Any process carried out to determine the condition of a patient's spleen.
http://purl.obolibrary.org/obo/NCIT_C156541	Separated	http://purl.obolibrary.org/obo/NCIT_C91106	Clinical or Research Assessment Answer		A person who is separated from their spouse, whether or not there is a legal arrangement.
http://purl.obolibrary.org/obo/SCDO_0000493	Health Service Utilization	http://purl.obolibrary.org/obo/SCDO_0000948	Quality of Health Care		The measure of the population's use of the health care services available to them. This includes the utilization of hospital resources, Personal Care Home (PCH) resources, and physician resources. Health care utilization and health status are used to examine how efficiently a health care system produces health in a population.
http://purl.obolibrary.org/obo/SCDO_0000742	Mefloquine	http://purl.obolibrary.org/obo/IDOMAL_0000122	Malaria Chemoprophylaxis		A phospholipid-interacting antimalarial drug (antimalarials). It is very effective against plasmodium falciparum with very few side effects.
http://purl.obolibrary.org/obo/SCDO_0000514	Hemoglobin S	http://purl.obolibrary.org/obo/SCDO_0003807	Abnormal Hemoglobin		An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.
http://purl.obolibrary.org/obo/SCDO_0001249	X-Ray Image	http://purl.obolibrary.org/obo/SCDO_1000313	Diagnostic Device Visual Output		The visual output that an X-ray machine produces.
http://purl.obolibrary.org/obo/SCDO_0000115	Beta Zero Thalassemia	http://purl.obolibrary.org/obo/SCDO_0000111	Beta Thalassemia		Beta-zero thalassemia is a form of beta-thalassemia in which beta-globin chain synthesis is absent. The clinical phenotype is often that of transfusion-dependant beta thalassemia major, however modifying factors may ameliorate the symptoms of severe anemia (Cao & Gallanelo, 2010).
http://purl.obolibrary.org/obo/SCDO_0007597	Descriptor of Consent	http://purl.obolibrary.org/obo/SCDO_0006339	Research		Information or a description of consent (hypothetical or obtained) or any aspect involved in or captured in the consent process.
http://purl.obolibrary.org/obo/SCDO_0009664	Abdominal Vaso-Occlusive Crisis	http://purl.obolibrary.org/obo/SCDO_0001229	Vaso-Occlusive Crisis		Pain resulting from tissue ischemia as a result of blockage of mesenteric blood vessels.
http://purl.obolibrary.org/obo/SCDO_0001049	Sickle Cell Disease Screening Test	http://purl.obolibrary.org/obo/SCDO_0000781	Mutation Carrier Screening		Sickle cell tests are used to help diagnose sickle cell anemia (also called sickle cell disease) and to identify those who may have sickle cell trait. Sickle cell anemia is an inherited disorder that leads to the production of an abnormal hemoglobin called hemoglobin S (Hb S or Hgb S). Sickle cell tests determine the presence and relative amount of hemoglobin S in a blood sample.
http://purl.obolibrary.org/obo/SCDO_1000067	Hemoglobin Genotype S/Beta Zero Thalassaemia	http://purl.obolibrary.org/obo/SCDO_1000107	Hemoglobin Genotype S/Beta Thalassemia		When one beta-globin gene carries the hemoglobin S mutation (beta6Glu>Val) whereas the other carries a null mutation, called beta-zero, because of the resulting inability to synthesize any beta-globin chain.
http://purl.obolibrary.org/obo/SCDO_0000706	obsolete Lymphoid System	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		'The lymphatic system in vertebrates is a network of conduits that carry a clear fluid called lymph. It also includes the lymphoid tissue through which the lymph travels. Lymphoid tissue is found in many organs, particularly the lymph nodes, and in the lymphoid follicles associated with the digestive system such as the tonsils. The system also includes all the structures dedicated to the circulation and production of lymphocytes, which includes the spleen, thymus, bone marrow and the lymphoid tissue associated with the digestive system. [Curator team: []]'
http://purl.obolibrary.org/obo/SCDO_0000249	obsolete Clinical Diagnostic Questionnaire	http://purl.obolibrary.org/obo/SCDO_0000957	obsolete Questionnaire		'A quick and accurate way of assessing the patient health states using well defined set of questions and analyzed for an optimal clinical decision for the patient. [Curator team: Gaston K. Mazandu]'
http://purl.obolibrary.org/obo/SCDO_1000839	Normal Partial Pressure of Carbon Dioxide	http://purl.obolibrary.org/obo/SCDO_1000812	Normal Metabolism/Homeostasis Phenotype		When the pressure exerted by carbon dioxide dissolved in the blood falls in the normal range.
http://purl.obolibrary.org/obo/SCDO_0000415	Electrocardiogram	http://purl.obolibrary.org/obo/SCDO_1000313	Diagnostic Device Visual Output		The visual output that an electrocardiograph produces.
http://purl.obolibrary.org/obo/SBO_0000316	MicroRNA	http://purl.obolibrary.org/obo/NCIT_C26548	Gene Product		Single-stranded RNA molecules thought to regulate the expression of other genes. miRNAs are encoded by genes that are transcribed from DNA but not translated into protein (non-coding RNA).
http://purl.obolibrary.org/obo/SCDO_0000950	Quality of Life and Care	http://purl.obolibrary.org/obo/SCDO_0001000	SCDO		The subjective measurement of an individual's sense of well-being and ability to enjoy life, and the levels of excellence which characterize the health service or health care provided to individuals based on accepted standards of quality.
http://purl.obolibrary.org/obo/SCDO_0000116	Beta-Globin Locus	http://purl.obolibrary.org/obo/SCDO_0000456	Globin Locus		A globin locus composed of five genes located on a short 45 kb region of chromosome 11. The order of genes in this cluster is: 5' - epsilon - gamma-G - gamma-A - delta - beta - 3'. It is responsible for the creation of the beta parts (roughly half) of the oxygen transport protein Hemoglobin.
http://purl.obolibrary.org/obo/SCDO_0000035	Alanine Aminotransferase Level	http://purl.obolibrary.org/obo/CMO_0000023	Blood Chemistry Measurement		The amount of alanine aminotransferase present in a specified volume of blood.
http://purl.obolibrary.org/obo/SCDO_1000826	Normal Mean Corpuscular Hemoglobin	http://purl.obolibrary.org/obo/SCDO_1000821	Normal Hematopoietic System Phenotype		When the average amount of hemoglobin per red blood cell (calculated by dividing the total mass of hemoglobin by the number of red blood cells in a volume of blood) falls in the normal range.
http://purl.obolibrary.org/obo/SCDO_1000383	Renal Complication	http://purl.obolibrary.org/obo/NCIT_C2959	Complication		Any kidney disorder occurring as a consequence of injury to the kidney.
http://purl.obolibrary.org/obo/SCDO_0002106	Splenic Infarction	http://purl.obolibrary.org/obo/HP_0001743	Abnormality of the Spleen		Insufficiency of arterial or venous blood supply to the spleen due to emboli, thrombi, vascular torsion, or pressure that produces a macroscopic area of necrosis.
http://purl.obolibrary.org/obo/SCDO_1000242	Autosomal Recessive Homozygous	http://purl.obolibrary.org/obo/HP_0000007	Autosomal Recessive		A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in individuals that are homozygotes (having two copies of the same mutant allele).
http://purl.obolibrary.org/obo/SCDO_1000834	Normal Reticulocyte Count	http://purl.obolibrary.org/obo/SCDO_1000821	Normal Hematopoietic System Phenotype		When the number of reticulocytes in a specified volume of blood falls in the normal range.
http://purl.obolibrary.org/obo/PR_000001318	L-Selectin	http://purl.obolibrary.org/obo/NCIT_C26548	Gene Product		A protein that is a translation product of the human SELL gene or a 1:1 ortholog thereof. It is a leukocyte adhesion receptor that play an important role in regulating the inflammatory response by mediating leukocyte tethering and rolling on adherent leukocytes.
http://purl.obolibrary.org/obo/UO_0000104	fL	http://purl.obolibrary.org/obo/UO_0000095	Volume Unit		A volume unit which is equal to 10^[-15] L.
http://purl.obolibrary.org/obo/UO_0000186	Dimensionless Unit	http://purl.obolibrary.org/obo/UO_0000000	Unit of Measurement		A unit which is a standard measure of physical quantity consisting of only a numerical number without any units.
http://purl.obolibrary.org/obo/UO_0000187	Percent	http://purl.obolibrary.org/obo/UO_0000190	Ratio		A dimensionless ratio unit which denotes numbers as fractions of 100.
http://purl.obolibrary.org/obo/VT_0000202	Alkaline Phosphatase Level	http://purl.obolibrary.org/obo/CMO_0000023	Blood Chemistry Measurement		The amount of alkaline phosphatase present in a specified volume of blood.
http://purl.obolibrary.org/obo/NCIT_C142494	Data Storage	http://purl.obolibrary.org/obo/SCDO_0006339	Research		To maintain data by placing the data, or a copy of the data, onto an electronically accessible device for preservation (either in plain-text or encrypted format).
http://purl.obolibrary.org/obo/NCIT_C142541	Research Ethics Committee	http://purl.obolibrary.org/obo/SCDO_1000430	Ethics Related Concept		An independent group that comprises medical, scientific, and non-scientific members, and is tasked with the continuing review and approval of research, including  clinical trials, with respect to the protocols, methods, and informed consent process to ensure the protection of the rights, safety, and wellbeing of participants.
http://purl.obolibrary.org/obo/SCDO_0000114	Beta Thalassemia Trait	http://purl.obolibrary.org/obo/SCDO_0000251	Clinical Phenotype of Beta Thalassemia		The inheritance of only one mutated beta-globin allele (beta+ or beta0).
http://purl.obolibrary.org/obo/NCIT_C164339	Date of Diagnosis	http://purl.obolibrary.org/obo/SCDO_1000538	Diagnosis Temporal Observable		The date on which a diagnosis of disease was made.
http://purl.obolibrary.org/obo/SCDO_0000194	Causal Adverse Drug Event Due to Genetic Predisposition	http://purl.obolibrary.org/obo/SCDO_0000191	Causal Adverse Drug Event		A causal adverse drug event that is induced by genetic predisposition.
http://purl.obolibrary.org/obo/SCDO_1000114	HBB, THR87LYS	http://purl.obolibrary.org/obo/SCDO_0002305	Hemoglobin D Disease Causal Mutation		A mutation where the threonine in position 87 in the primary sequence of a beta-chain produced by the HBB gene is replaced by lysine.
http://purl.obolibrary.org/obo/SCDO_0000878	PedsQL Sickle Cell Disease Module	http://purl.obolibrary.org/obo/NCIT_C78652	Pediatric Quality of Life Inventory (PedsQL)		The PedsQL Sickle Cell Disease Module includes 43 items from 9 subscales: Pain and Hurt (9 items); Pain Impact (10 items); Pain Management and Control (2 items); Worry (5 items); Worry II (2 items); Emotions (2 items); Treatment (7 items); Communication I (3 items); and Communication II (3 items). For all ages, each item asks how much of a problem there has been in the past month. There are self- or parent-reported forms for ages 8 to 18, and responses are scored on a 5-point Likert-style scale (0 = never a problem; 1 = almost never a problem; 2 = sometimes a problem; 3 = often a problem; 4 = almost always a problem). Forms for children ages 5 to 7 are interviewer-administered, and responses include a 3-point Likert-style scale (0 = not at all a problem; 2 = sometimes a problem; 4 = a lot of a problem). Items are reversed-scored and converted to a 100-point scale (0 = 100, 1 = 75, 2 = 50, 3 = 25, 4 = 0) with higher scores indicating better quality of life. Scores for individual subscales are the sum of items divided by the total number or items answered. The total score for the PedsQL Sickle Cell Disease Module is the sum of the items divided by the number of items answered.
http://purl.obolibrary.org/obo/SCDO_0000119	Bilirubin Blood Test	http://purl.obolibrary.org/obo/NCIT_C74954	Liver Function Test		A bioassay to measure levels of bilirubin, a yellow substance found in bile produced when the liver breaks down old red blood cells.
http://purl.obolibrary.org/obo/HP_0012819	Myocarditis	http://purl.obolibrary.org/obo/HP_0030680	Abnormal Cardiovascular System Morphology		Inflammation of the myocardium.
http://purl.obolibrary.org/obo/HP_0025066	Decreased Mean Corpuscular Volume	http://purl.obolibrary.org/obo/HP_0025065	Abnormal Mean Corpuscular Volume		A reduction from normal of the mean corpuscular volume, or mean cell volume (MCV) of red blood cells (usually defined as an MCV below 80 femtoliters).
http://purl.obolibrary.org/obo/HP_0025142	Constitutional Symptom	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		A symptom or manifestation indicating a systemic or general effect of a disease and that may affect the general well-being or status of an individual.
http://purl.obolibrary.org/obo/HP_0030049	Brain Abscess	http://purl.obolibrary.org/obo/HP_0012639	Abnormal Nervous System Morphology		A collection of pus, immune cells, and other material in the brain.
http://purl.obolibrary.org/obo/HP_0030050	Narcolepsy	http://purl.obolibrary.org/obo/HP_0000708	Behavioural Abnormality		An abnormal phenomenon characterized by a classic tetrad of excessive daytime sleepiness with irresistible sleep attacks, cataplexy (sudden bilateral loss of muscle tone), hypnagogic hallucination, and sleep paralysis.
http://purl.obolibrary.org/obo/HP_0030058	Sickled Erythrocyte	http://purl.obolibrary.org/obo/HP_0004447	Poikilocytosis		An irreversible distortion of the morphology of an erythrocyte such that the cells are elongated and curved, resembling the blade of a sickle (the hand-held agricultural tool traditionally used to harvest grains).
http://purl.obolibrary.org/obo/HP_0030127	Endometriosis	http://purl.obolibrary.org/obo/HP_0012243	Abnormal Reproductive System Morphology		The growth of endometrial tissue outside the uterus.
http://purl.obolibrary.org/obo/HP_0030243	Hepatic Vein Thrombosis	http://purl.obolibrary.org/obo/HP_0001977	Abnormal Thrombosis		An obstruction in the veins of the liver caused by a blood clot (thrombosis).
http://purl.obolibrary.org/obo/HP_0030248	Mesenteric Venous Thrombosis	http://purl.obolibrary.org/obo/HP_0001977	Abnormal Thrombosis		A clot that obstructs blood flow in a mesenteric vein (the superior and the inferior mesenteric vein drain blood from the small and large intestine).
http://purl.obolibrary.org/obo/HP_0045040	Abnormal Lactate Dehydrogenase Level	http://purl.obolibrary.org/obo/HP_0012379	Abnormal Enzyme/Coenzyme Activity		A deviation from the normal serum concentration/activity of lactate dehydrogenase (LDH), which catalyzes the reduction of pyruvate to form lactate.
http://purl.obolibrary.org/obo/HP_0045048	Increased Hemoglobin A2	http://purl.obolibrary.org/obo/HP_0020063	Increased Hemoglobin Concentration		An elevated concentration in the blood of hemoglobin A2 (HbA2), which is a normal variant of hemoglobin A that consists of two alpha and two delta chains and is normally present at low levels in adults but may be increased in beta thalassemia.
http://purl.obolibrary.org/obo/NBO_0000131	Alcohol Intake	http://purl.obolibrary.org/obo/SCDO_0000487	Health Behaviour		A drinking behavior associated with the intake of alcohol.
http://purl.obolibrary.org/obo/IDO_0000515	Microbiome	http://purl.obolibrary.org/obo/SCDO_0000122	Biological Disease Modifier		An organism population whose members are particpating in non-parasitic symbiosis with a particular host.
http://purl.obolibrary.org/obo/IDO_0000560	Antifungal	http://purl.obolibrary.org/obo/CHEBI_23888	Drug		A material entity bearing an antifungal disposition.
http://purl.obolibrary.org/obo/HP_0000084	Kidney Failure	http://purl.obolibrary.org/obo/SCDO_1000383	Renal Complication		Failure of the kidneys to adequately filter toxins and waste products from the blood; classified as acute (as in acute kidney injury) or chronic (as in chronic kidney disease); a number of other diseases or health problems may cause either form of renal failure to occur.
http://purl.obolibrary.org/obo/HP_0032224	ABO Blood Group	http://purl.obolibrary.org/obo/SCDO_0009884	Biochemical Phenotype		The ABO histo-blood group consists of two antigens (A and B antigens) and four blood types (types A, B, AB, and O). The A and B antigens are the product of the ABO gene and are autosomal codominant. The group O phenotype is an autosomal-recessive phenotype due to the homozygous inheritance of two null ABO alleles. Group O individuals express the H antigen, the biosynthetic precursor to A and B antigens. ABO, therefore, is the blood type, whereas A, B, and H refer to the antigens. The ABO system consists of A and B antigens and antibodies against these antigens.
http://purl.obolibrary.org/obo/NCIT_C168823	Year of Diagnosis	http://purl.obolibrary.org/obo/SCDO_1000538	Diagnosis Temporal Observable		The year when a diagnosis was assigned to an individual's condition.
http://purl.obolibrary.org/obo/SCDO_0000298	Cross-Sectional Studies	http://purl.obolibrary.org/obo/SCDO_0000437	Epidemiologic Studies		Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with longitudinal studies which are followed over a period of time.
http://purl.obolibrary.org/obo/SCDO_0000312	D57.0 Hb-SS disease with crisis	http://purl.obolibrary.org/obo/SCDO_0000311	D57 Sickle-Cell Disorders		Broad term used to describe several different acute conditions occurring with sickle cell disease, including aplastic crisis, hemolytic crisis, and vasoocclusive crisis.
http://purl.obolibrary.org/obo/SCDO_0000531	Hemoglobin E Trait	http://purl.obolibrary.org/obo/NCIT_C95534	Hemoglobin Trait		The inheritance of the gene for hemoglobin E from one parent and a gene for normal adult hemoglobin (hemoglobin A) from the other parent.
http://purl.obolibrary.org/obo/SCDO_0000677	Kinesiotherapy	http://purl.obolibrary.org/obo/SCDO_0000978	Rehabilitation		A specialized area of medicine in which exercise and movement are used as the primary form of rehabilitation.
http://purl.obolibrary.org/obo/DUO_0000018	Not for Profit Use Only	http://purl.obolibrary.org/obo/SCDO_1000408	Data Use Requirements		This requirement indicates that use of the data is limited to not-for-profit organizations and not-for-profit use, non-commercial use.
http://purl.obolibrary.org/obo/DUO_0000019	Publication Required	http://purl.obolibrary.org/obo/SCDO_1000408	Data Use Requirements		This requirement indicates that requestor agrees to make results of studies using the data available to the larger scientific community.
http://purl.obolibrary.org/obo/DUO_0000020	Collaboration Required	http://purl.obolibrary.org/obo/SCDO_1000408	Data Use Requirements		This could be coupled with a string describing the primary study investigator(s).
http://purl.obolibrary.org/obo/DUO_0000021	Ethics Approval Required	http://purl.obolibrary.org/obo/SCDO_1000408	Data Use Requirements		This requirement indicates that the requestor must provide documentation of local IRB/ERB approval.
http://purl.obolibrary.org/obo/DUO_0000022	Geographical Restriction	http://purl.obolibrary.org/obo/SCDO_1000408	Data Use Requirements		This should be coupled with an ontology term describing the geographical location the restriction applies to.
http://purl.obolibrary.org/obo/DUO_0000024	Publication Moratorium	http://purl.obolibrary.org/obo/SCDO_1000408	Data Use Requirements		This should be coupled with a date specified as ISO8601
http://purl.obolibrary.org/obo/DUO_0000025	Time Limit on Use	http://purl.obolibrary.org/obo/SCDO_1000408	Data Use Requirements		This should be coupled with an integer value indicating the number of months.
http://purl.obolibrary.org/obo/DUO_0000026	User Specific Restriction	http://purl.obolibrary.org/obo/SCDO_1000408	Data Use Requirements		This requirement indicates that use is limited to use by approved users.
http://purl.obolibrary.org/obo/DUO_0000027	Project Specific Restriction	http://purl.obolibrary.org/obo/SCDO_1000408	Data Use Requirements		This requirement indicates that use is limited to use within an approved project.
http://purl.obolibrary.org/obo/DUO_0000028	Institution Specific Restriction	http://purl.obolibrary.org/obo/SCDO_1000408	Data Use Requirements		This requirement indicates that use is limited to use within an approved institution.
http://purl.obolibrary.org/obo/DUO_0000029	Return to Database or Resource	http://purl.obolibrary.org/obo/SCDO_1000408	Data Use Requirements		This requirement indicates that the requestor must return derived/enriched data to the database/resource.
http://purl.obolibrary.org/obo/ENVO_02500036	Pollution	http://purl.obolibrary.org/obo/SCDO_0000897	Physical Environment		An environmental system process that results in the introduction of contaminants into an environment.
http://purl.obolibrary.org/obo/NCIT_C20197	Male	http://purl.obolibrary.org/obo/NCIT_C91106	Clinical or Research Assessment Answer		A person who belongs to the sex that normally produces sperm. The term is used to indicate biological sex distinctions, cultural gender role distinctions, or both.
http://purl.obolibrary.org/obo/NCIT_C20629	Silent Mutation	http://purl.obolibrary.org/obo/NCIT_C62200	Point Mutation		A point mutation occurring within the protein-coding region of a gene, and which codes for the same amino acid as expected.
http://purl.obolibrary.org/obo/NCIT_C20711	SP1 Gene	http://purl.obolibrary.org/obo/NCIT_C16612	Gene		This gene plays a role in transcriptional regulation and is involved in several signal transduction pathways.
http://purl.obolibrary.org/obo/NCIT_C63547	Haplotype	http://purl.obolibrary.org/obo/SCDO_0004061	Genotype		A way of denoting the collective genotype of a number of closely linked loci on a chromosome.
http://purl.obolibrary.org/obo/NCIT_C34465	Cholecystitis	http://purl.obolibrary.org/obo/HP_0025031	Abnormality of the Digestive System		An acute or chronic inflammation involving the gallbladder wall. It may be associated with the presence of gallstones.
http://purl.obolibrary.org/obo/NCIT_C34887	Peri-Operative Pain	http://purl.obolibrary.org/obo/SCDO_0000851	Pain		A sensation of discomfort secondary to surgery.
http://purl.obolibrary.org/obo/NCIT_C35069	Thalassemia	http://purl.obolibrary.org/obo/SCDO_0007192	Quantitative Hemoglobinopathy		An inherited blood disorder characterized by a decreased synthesis of one of the polypeptide chains that form hemoglobin. Anemia results from this abnormal hemoglobin formation.
http://purl.obolibrary.org/obo/NCIT_C35146	Chronic Cholecystitis	http://purl.obolibrary.org/obo/NCIT_C34465	Cholecystitis		Cholecystitis that is persistent and long-standing.
http://purl.obolibrary.org/obo/NCIT_C35152	Acute Cholecystitis	http://purl.obolibrary.org/obo/NCIT_C34465	Cholecystitis		Acute inflammation of the gallbladder.
http://purl.obolibrary.org/obo/NCIT_C35372	Ascending Cholangitis	http://purl.obolibrary.org/obo/HP_0025031	Abnormality of the Digestive System		Acute infection of the bile ducts caused by bacteria ascending from the small intestine.
http://purl.obolibrary.org/obo/NCIT_C35447	Osteonecrosis of the Femoral Head	http://purl.obolibrary.org/obo/HP_0010885	Osteonecrosis		Necrotic changes in the bone tissue of the femoral head due to interruption of blood supply.
http://purl.obolibrary.org/obo/NCIT_C50791	Urinary Tract Infection	http://purl.obolibrary.org/obo/IDO_0000586	Infection		A bacterial infectious process affecting any part of the urinary tract, most commonly the bladder and the urethra. Symptoms include urinary urgency and frequency, burning sensation during urination, lower abdominal discomfort, and cloudy urine.
http://purl.obolibrary.org/obo/NCIT_C96239	Glomerular Hypertrophy	http://purl.obolibrary.org/obo/HP_0000077	Abnormality of the Kidney		A morphologic finding indicating enlargement of the glomeruli in a kidney specimen.
http://purl.obolibrary.org/obo/NCIT_C49674	Breaths per Minute	http://purl.obolibrary.org/obo/UO_0000280	Rate Unit		The number of breaths (inhalation and exhalation) taken per minute time.
http://purl.obolibrary.org/obo/NCIT_C50474	Bradypnea	http://purl.obolibrary.org/obo/HP_0002086	Abnormality of the Respiratory System		Abnormal decrease of rate of breathing.
http://purl.obolibrary.org/obo/NCIT_C50767	Tachypnea	http://purl.obolibrary.org/obo/HP_0002086	Abnormality of the Respiratory System		Abnormal increase of rate of breathing.
http://purl.obolibrary.org/obo/NCIT_C51677	Liver Biopsy	http://purl.obolibrary.org/obo/SCDO_0000082	Diagnostic Technique, Method, Test or Assay		Removal of tissue from the liver for microscopic examination.
http://purl.obolibrary.org/obo/NCIT_C51773	Married	http://purl.obolibrary.org/obo/NCIT_C91106	Clinical or Research Assessment Answer		Indicates a person currently joined in a legally binding matrimonial union. Classify common law marriage as married. Includes married couples living together and not living together.
http://purl.obolibrary.org/obo/NCIT_C51774	Never Been Married	http://purl.obolibrary.org/obo/NCIT_C91106	Clinical or Research Assessment Answer		Indicates a person who has never been married or whose marriages have been annulled.
http://purl.obolibrary.org/obo/NCIT_C51775	Widowed	http://purl.obolibrary.org/obo/NCIT_C91106	Clinical or Research Assessment Answer		Indicates a person who is no longer married because of the death of his/her spouse and has not remarried.
http://purl.obolibrary.org/obo/NCIT_C51776	Divorced	http://purl.obolibrary.org/obo/NCIT_C91106	Clinical or Research Assessment Answer		Indicates a person whose marriage has been legally dissolved and has not remarried.
http://purl.obolibrary.org/obo/NCIT_C51993	Antibiotic Prophylaxis	http://purl.obolibrary.org/obo/SCDO_0000930	Infection Prophylaxis		Administration of antibiotics with the intent of preventing bacterial infection.
http://purl.obolibrary.org/obo/NCIT_C52009	Amniocentesis	http://purl.obolibrary.org/obo/SCDO_0000919	Prenatal Screening for Sickle Cell		A prenatal diagnostic procedure in which a small sample of amniotic fluid is removed from the uterus by a needle inserted into the abdomen. This procedure is used to detect various genetic abnormalities in the fetus and/or the sex of the fetus.
http://purl.obolibrary.org/obo/NCIT_C67015	mg/dL	http://purl.obolibrary.org/obo/UO_0000180	Mass Per Unit Volume		A unit of mass concentration defined as the concentration of one milligram of a substance in unit volume of the mixture equal to one cubic deciliter or 100 cubic centimeters. It is also a unit of mass density (volumic mass) defined as the density of substance which mass equal to one milligram occupies the volume one cubic deciliter or 100 cubic centimeters.
http://purl.obolibrary.org/obo/NCIT_C67244	thousand cells per microliter	http://purl.obolibrary.org/obo/UO_0000316	cells per microliter		A unit of cell concentration expressed as a number of cells in thousands per unit volume equal to one microliter.
http://purl.obolibrary.org/obo/NCIT_C67251	million cells per microliter	http://purl.obolibrary.org/obo/UO_0000316	cells per microliter		A unit of cell concentration expressed as a number of cells in millions per unit volume equal to one microliter.
http://purl.obolibrary.org/obo/NCIT_C67376	IU/L	http://purl.obolibrary.org/obo/UO_0000051	Concentration Unit		Unit of arbitrary substance concentration (biologic activity concentration) defined as the concentration of one international unit per one liter of the system volume.
http://purl.obolibrary.org/obo/NCIT_C68615	Birth Date	http://purl.obolibrary.org/obo/NCIT_C16495	Demographic Factor		The calendar date on which a person was born.
http://purl.obolibrary.org/obo/NCIT_C69256	Subject Unique Identifier	http://purl.obolibrary.org/obo/NCIT_C19332	Personal Attribute		A unique identifier for a subject in a study.
http://purl.obolibrary.org/obo/NCIT_C78393	Iron Overload	http://purl.obolibrary.org/obo/SCDO_0002674	Abnormality of Metabolism/Homeostasis		Accumulation of iron in the tissues. It may be a manifestation of an inherited disorder (e.g., hemochromatosis) or acquired (in patients with repeated blood transfusions). Symptoms include hepatomegaly, arthritis, diabetes mellitus, and bronzed skin. If untreated it has a progressive course and may lead to death.
http://purl.obolibrary.org/obo/NCIT_C78598	Posterior Reversible Leukoencephalopathy	http://purl.obolibrary.org/obo/HP_0012638	Abnormal Nervous System Physiology		An acute or subacute reversible condition characterized by headaches, mental status changes, visual disturbances, and seizures associated with imaging findings of posterior leukoencephalopathy. It has been observed in association with hypertensive encephalopathy, eclampsia, and immunosuppressive and cytotoxic drug treatment.
http://purl.obolibrary.org/obo/NCIT_C78638	Thrombus in Catheter	http://purl.obolibrary.org/obo/NCIT_C78254	Device Complication		The development of a blood clot in a catheter.
http://purl.obolibrary.org/obo/NCIT_C79903	Blood Smear	http://purl.obolibrary.org/obo/SCDO_0000133	Blood Test		A sample of blood applied in a thin film to a microscope slide for study under a microscope.
http://purl.obolibrary.org/obo/NCIT_C80411	Right Heart Catheterization	http://purl.obolibrary.org/obo/SCDO_0000500	Heart Function Test		A diagnostic procedure in which a catheter is guided into the right heart, where pressures may be measured and radiocontrast material may be injected to visualize blood flow in and around the right heart.
http://purl.obolibrary.org/obo/NCIT_C81229	Alcohol Use History	http://purl.obolibrary.org/obo/SCDO_0001120	Substance Use History		A description of an individual's current and past experience with alcoholic beverage consumption.
http://purl.obolibrary.org/obo/NCIT_C81262	Medical Record Number	http://purl.obolibrary.org/obo/NCIT_C69256	Subject Unique Identifier		An identifying number within an institution that is used to reference a subject's medical information.
http://purl.obolibrary.org/obo/NCIT_C141366	Hemoglobin Lepore Syndrome	http://purl.obolibrary.org/obo/SCDO_0000343	Delta Beta Thalassemia		A rare autosomal recessive hemoglobinopathy, caused by the presence of two deltabeta globin fusion chains, which occurs due to a crossover between the delta (HBD) and beta globin (HBB) gene loci during meiosis.
http://purl.obolibrary.org/obo/ARO_0000006	Erythromycin	http://purl.obolibrary.org/obo/NCIT_C258	Antibiotic		Erythromycin is a macrolide antibiotic with a 14-carbon ring that has an antimicrobial spectrum similar to or slightly wider than that of penicillin, and is often used for people that have an allergy to penicillins. Erythromycin may possess bacteriocidal activity, particularly at higher concentrations by binding to the 50S subunit of the bacterial 70S rRNA complex, inhibiting peptidyl-tRNA translocation. Thus, protein synthesis and subsequently structure/function processes critical for life or replication are inhibited.
http://purl.obolibrary.org/obo/ARO_0000054	Penicillin	http://purl.obolibrary.org/obo/NCIT_C258	Antibiotic		Penicillin (sometimes abbreviated PCN) is a beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually Gram-positive, organisms. It works by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms.
http://purl.obolibrary.org/obo/ARO_0000064	Amoxycillin	http://purl.obolibrary.org/obo/ARO_0000054	Penicillin		Amoxicillin is a moderate-spectrum, bacteriolytic, beta-lactam antibiotic used to treat bacterial infections caused by susceptible microorganisms. A derivative of penicillin, it has a wider range of treatment but remains relatively ineffective against Gram-negative bacteria. It is commonly taken with clavulanic acid, a beta-lactamase inhibitor. Like other beta-lactams, amoxicillin interferes with the synthesis of peptidoglycan.
http://purl.obolibrary.org/obo/NCIT_C152089	Voxelotor	http://purl.obolibrary.org/obo/CHEBI_23888	Drug		An orally bioavailable modulator and stabilizer of sickle cell hemoglobin (HbS), with potential use in the treatment of sickle cell disease (SCD). Upon administration, voxelotor targets and covalently binds to the N-terminal valine of the alpha chain of HbS. This stabilizes HbS, thereby improving oxygen binding affinity. The binding of voxelotor to HbS prevents HbS polymerization, reduces sickling, decreases red blood cell (RBC) damage and increases the half-life of RBCs. This improves blood flow and decreases hemolytic anemia.
http://purl.obolibrary.org/obo/SCDO_0000330	D57.80 Other sickle-cell disorders without crisis	http://purl.obolibrary.org/obo/SCDO_0000329	D57.8 Other sickle-cell disorders		-
http://purl.obolibrary.org/obo/SCDO_0000024	deprecated-Adherence	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		The extent to which a person's behaviour - taking medications, following a diet and/or executing life style changes, corresponds to agreed recommendations by a health care provider.
http://purl.obolibrary.org/obo/SCDO_0000122	Biological Disease Modifier	http://purl.obolibrary.org/obo/SCDO_0000391	Disease Modifier		A biological factor that modifies one or more aspects of a disease, such as sickle cell disease (SCD) (e.g. aspects such as temporal pattern, age of onset and mortality), for specific phenotype(s) of the disease.
http://purl.obolibrary.org/obo/SCDO_0000616	Immunochemical Assay	http://purl.obolibrary.org/obo/NCIT_C16723	Immunological Assay		An assay that identifies a substance (especially a protein) by its action as an antigen.
http://purl.obolibrary.org/obo/SCDO_0001206	Urinary Creatinine Test	http://purl.obolibrary.org/obo/SCDO_0000676	Kidney Function Test		A bioassay to measure urine concentration of creatinine, a muscle metabolite that is filtered out of blood by the kidneys.
http://purl.obolibrary.org/obo/NCIT_C16723	Immunological Assay	http://purl.obolibrary.org/obo/SCDO_0000120	Biochemical Assay		Laboratory test involving interaction of antigens with specific antibodies.
http://purl.obolibrary.org/obo/NCIT_C19332	Personal Attribute	http://purl.obolibrary.org/obo/SCDO_0001000	SCDO		The distinguishing qualities or prominent aspects of an individual person.
http://purl.obolibrary.org/obo/NCIT_C26548	Gene Product	http://purl.obolibrary.org/obo/SCDO_0001000	SCDO		A protein, RNA or a complex that contains proteins and/or RNA.
http://purl.obolibrary.org/obo/NCIT_C2959	Complication	http://purl.obolibrary.org/obo/HP_0000118	Abnormal Phenotype		Any disease or disorder that occurs during the course of, or because of, another disease, treatment, or procedure.
http://purl.obolibrary.org/obo/NCIT_C34941	Pregnancy Complication	http://purl.obolibrary.org/obo/NCIT_C2959	Complication		The co-occurrence of pregnancy and a disease. The disease may precede or follow conception and it may or may not have a deleterious effect on the pregnant woman or fetus.
http://purl.obolibrary.org/obo/NCIT_C91105	Clinical or Research Assessment Questionnaire	http://purl.obolibrary.org/obo/SCDO_1000472	Data Standards		An instrument consisting of a predetermined set of questions for a clinical or research assessment.
http://purl.obolibrary.org/obo/NCIT_C91106	Clinical or Research Assessment Answer	http://purl.obolibrary.org/obo/SCDO_1000472	Data Standards		A statement (either spoken or written) that is made in reply to a clinical research assessment question.
http://purl.obolibrary.org/obo/NCIT_C98805	Acquired Methemoglobinemia	http://purl.obolibrary.org/obo/SCDO_0000753	Methemoglobinemia		Methemoglobinemia that is caused by exposure to certain drugs (xylocaine and benzene) and nitrate-rich foods.
http://purl.obolibrary.org/obo/NCIT_C122931	Imaging Transcranial Doppler Ultrasonography	http://purl.obolibrary.org/obo/NCIT_C154865	Cerebral Blood Flow Assay		A diagnostic technique that uses pulsed Doppler ultrasound to both identify blood vessels in the brain and measure the velocity of blood flow through those vessels. It allows a more accurate estimation of stroke risk because it allows outlining of parenchymal structures and visualization of the examined vessels.
http://purl.obolibrary.org/obo/NCIT_C123446	Continuous Ambulatory ECG	http://purl.obolibrary.org/obo/SCDO_0000500	Heart Function Test		A continuous electrocardiographic (ECG) recording that utilizes one or more leads that both records and stores data directly to a device worn by the subject, such that the subject need not be restricted to a medical facility, and may be able to participate in their customary activities of daily living.
http://purl.obolibrary.org/obo/NCIT_C123667	Global Mental Status Screener - Adult	http://purl.obolibrary.org/obo/SCDO_0000455	Global Mental Status Screener		A standardized rating scale developed by Ziad Nasreddine in 1996 to screen for mild cognitive dysfunction and impairment. This instrument assesses the following cognitive domains: attention and concentration, executive functions, memory, language, visuoconstructional skills, conceptual thinking, calculations, and orientation
http://purl.obolibrary.org/obo/NCIT_C124059	Pulmonary Consolidation	http://purl.obolibrary.org/obo/HP_0030680	Abnormal Cardiovascular System Morphology		A chest X-ray finding indicating the presence of a radio-opaque area in the lung. The opacification is caused by fluid or solid material within the airways or lung parenchyma.
http://purl.obolibrary.org/obo/NCIT_C124065	Hepatic Iron Concentration	http://purl.obolibrary.org/obo/SCDO_0000728	Diagnostic Measurement		A measurement of the concentration of iron in the liver as an estimate of body iron load.
http://purl.obolibrary.org/obo/NCIT_C124475	Mid Upper Arm Circumference	http://purl.obolibrary.org/obo/CMO_0000021	Body Morphological Measurement		A circumferential measurement of the largest part of the upper arm.
http://purl.obolibrary.org/obo/NCIT_C28421	Sex	http://purl.obolibrary.org/obo/NCIT_C16495	Demographic Factor		The totality of characteristics of reproductive structure, functions, phenotype, and genotype, differentiating the male from the female organism.
http://purl.obolibrary.org/obo/NCIT_C71746	Vascular Access Device Complications	http://purl.obolibrary.org/obo/NCIT_C78254	Device Complication		Difficulties related to an apparatus used to gain access to arteries and veins.
http://purl.obolibrary.org/obo/NCIT_C74954	Liver Function Test	http://purl.obolibrary.org/obo/SCDO_0000902	Physiological Assay		The quantitative measurement of liver enzymes in the blood, which is useful in assessing the functional state of a patient's liver. Liver function tests include the measurement of albumin, alanine transaminase, aspartate transaminase, alkaline phosphatase, bilirubin, and gamma glutamyl transferase.
http://purl.obolibrary.org/obo/NCIT_C15238	Gene Therapy	http://purl.obolibrary.org/obo/SCDO_0000301	Curative Therapeutics		Application of genetic material (usually DNA) into cells in order to permanently correct an inherited disease or acquired disease.
http://purl.obolibrary.org/obo/NCIT_C15320	Study Design	http://purl.obolibrary.org/obo/SCDO_0300005	Research Characteristics		A plan detailing how a study will be performed in order to represent the phenomenon under examination, to answer the research questions that have been asked, and defining the methods of data analysis. Study design is driven by research hypothesis being posed, study subject/population/sample available, logistics/resources: technology, support, networking, collaborative support, etc.
http://purl.obolibrary.org/obo/NCIT_C15709	Genetic Testing	http://purl.obolibrary.org/obo/SCDO_0000448	Genetic Technique		The process of isolating and testing the DNA of an embryo or a person to detect the presence of genetic alterations or defects that may predispose to the future development of a disease or disorder.
http://purl.obolibrary.org/obo/NCIT_C15900	Lifestyle Therapy	http://purl.obolibrary.org/obo/SCDO_0001152	Therapeutics		Therapy dealing with lifestyle management and includes: behavioral and dietary modifications, exercise, stress management, and addiction control. This therapy must be used as major adjunct to 'standard care' or be applied as alternative treatment to conventional medicine practices.
http://purl.obolibrary.org/obo/NCIT_C2905	Bone Marrow Hyperplasia	http://purl.obolibrary.org/obo/HP_0001871	Abnormality of Blood and Blood-Forming Tissues		Increase in the number of hematopoietic cells in the bone marrow. It may involve all or individual hematopoietic cell lines.
http://purl.obolibrary.org/obo/NCIT_C29107	IV fluids	http://purl.obolibrary.org/obo/SCDO_0000922	Preventative Therapeutics		A sterile liquid preparation infused into a vein. IV fluid is prescribed as a replacement of fluid, electrolytes, calories, vitamins, and other nutritional substances. In addition, IV fluids are used to administer blood products and medications such as chemotherapy. Examples of IV fluids include Normal Saline, Ringers Solution, and Lactated Ringers Solution.
http://purl.obolibrary.org/obo/NCIT_C29719	Smoking History	http://purl.obolibrary.org/obo/SCDO_0001120	Substance Use History		A record of an individual's background in regard to smoking tobacco. This would include such factors as start date, end date (if applicable), number of cigarette smoked, attempts to quit, and others.
http://purl.obolibrary.org/obo/NCIT_C30142	History of Transfusion	http://purl.obolibrary.org/obo/NCIT_C18772	Personal Medical History		An account of all experiences related to the receipt of blood, WBC, platelets, and/or other blood components.
http://purl.obolibrary.org/obo/NCIT_C61797	Ketamine	http://purl.obolibrary.org/obo/CHEBI_23888	Drug		A cyclohexanone derivative with analgesic and anesthetic properties. Although its mechanism of action is not well understood, ketamine appears exerts complex pharmacological actions including inhibition of biogenic amine uptake, binding to opioid receptors, and inhibition of N-methyl D-aspartate (NMDA) receptors. Because of the involvement of spinal NMDA receptors in the process of central sensitization, this agent may reduce pain perception and induce sedation.
http://purl.obolibrary.org/obo/NCIT_C62005	Amitriptyline	http://purl.obolibrary.org/obo/CHEBI_23888	Drug		A derivative of dibenzocycloheptadiene and a tricyclic antidepressant. Amitriptyline inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity.
http://purl.obolibrary.org/obo/NCIT_C48660	NA	http://purl.obolibrary.org/obo/NCIT_C91106	Clinical or Research Assessment Answer		Determination of a value is not relevant in the current context.
http://purl.obolibrary.org/obo/NCIT_C64387	Millimole per Liter	http://purl.obolibrary.org/obo/UO_0000051	Concentration Unit		A unit of concentration (molarity unit) equal to one millimole of solute per liter of solution.
http://purl.obolibrary.org/obo/NCIT_C64572	microgram per millilitre	http://purl.obolibrary.org/obo/UO_0000180	Mass Per Unit Volume		A metric unit of mass concentration defined as the concentration of one gram of a substance per unit volume of the mixture equal to one cubic meter. The concept also refers to the metric unit of mass density (volumic mass) defined as the density of a substance which mass equal to one gram occupies the volume of one cubic meter.
http://purl.obolibrary.org/obo/NCIT_C64625	Pregabalin	http://purl.obolibrary.org/obo/SCDO_0000809	Non Opioid		A 3-isobutyl derivative of gamma-amino butyric acid (GABA) with anti-convulsant, anti-epileptic, anxiolytic, and analgesic activities. Although the exact mechanism of action is unknown, pregabalin selectively binds to alpha2delta (A2D) subunits of presynaptic voltage-dependent calcium channels (VDCCs) located in the central nervous system (CNS). Binding of pregabalin to VDCC A2D subunits prevents calcium influx and the subsequent calcium-dependent release of various neurotransmitters, including glutamate, norepinephrine, serotonin, dopamine, and substance P, from the presynaptic nerve terminals of hyperexcited neurons; synaptic transmission is inhibited and neuronal excitability is diminished. Pregabalin does not bind directly to GABA-A or GABA-B receptors and does not alter GABA uptake or degradation.
http://purl.obolibrary.org/obo/NCIT_C64783	g/dL	http://purl.obolibrary.org/obo/UO_0000180	Mass Per Unit Volume		A unit of mass concentration defined as the concentration of one gram of a substance per unit volume of the mixture equal to one deciliter (100 milliliters). The concept also refers to the metric unit of mass density (volumic mass) defined as the density of substance which mass equal to one gram occupies the volume one deciliter.
http://purl.obolibrary.org/obo/NCIT_C82909	Mild Anemia	http://purl.obolibrary.org/obo/HP_0001903	Anemia		Anemia not associated with symptoms of fatigue, headaches, palpitations, or shortness of breath. In asymptomatic anemia the hematocrit levels usually range from 32 to 35%.
http://purl.obolibrary.org/obo/NCIT_C83031	Visit Date	http://purl.obolibrary.org/obo/EUPATH_0000310	Information on Observation Details		The date on which a visit occurred.
http://purl.obolibrary.org/obo/NCIT_C84481	Hereditary Hemochromatosis	http://purl.obolibrary.org/obo/NCIT_C78393	Iron Overload		An inherited metabolic disorder characterized by iron accumulation in the tissues.
http://purl.obolibrary.org/obo/NCIT_C84979	Hemoglobin Subunit Epsilon	http://purl.obolibrary.org/obo/SCDO_1000012	Beta-Globin Family Members		Hemoglobin subunit epsilon (147 aa, ~16 kDa) is encoded by the human HBE1 gene. This protein plays a role in the transport of oxygen to tissues of the embryo.
http://purl.obolibrary.org/obo/NCIT_C84980	Hemoglobin Subunit Delta	http://purl.obolibrary.org/obo/SCDO_1000012	Beta-Globin Family Members		A type of polypeptide chain that when in combination with alpha globin polypeptide chains forms adult hemoglobin 2 (HbA2). HbA2 comprises around 3% of adult hemoglobin. Hemoglobin subunit delta (147 aa, ~16 kDa) is encoded by the human HBD gene. This protein plays a role in the transport of oxygen to tissues of the adult body.
http://purl.obolibrary.org/obo/NCIT_C84983	Hemoglobin Subunit Beta	http://purl.obolibrary.org/obo/SCDO_1000012	Beta-Globin Family Members		Hemoglobin subunit beta (147 aa, ~16 kDa) is encoded by the human HBB gene. This protein plays a role in the transport of oxygen to tissues of the adult body.
http://purl.obolibrary.org/obo/NCIT_C99042	Renal Vein Thrombosis	http://purl.obolibrary.org/obo/HP_0001977	Abnormal Thrombosis		The formation of a thrombus in the renal vein.
http://purl.obolibrary.org/obo/GSSO_000109	Intersex	http://purl.obolibrary.org/obo/NCIT_C91106	Clinical or Research Assessment Answer		Intersex is an umbrella term with a complex history. It is usually used to refer to persons with congenital conditions which involve differences in the many intertwined processes of sexual development.
http://purl.obolibrary.org/obo/SCDO_0000317	D57.20 Sickle-cell/Hb-C disease without crisis	http://purl.obolibrary.org/obo/SCDO_0000316	D57.2 Sickle-cell/Hb-C disease		-
http://purl.obolibrary.org/obo/SCDO_0000072	Arteriovenous Malformation	http://purl.obolibrary.org/obo/HP_0030680	Abnormal Cardiovascular System Morphology		Abnormal formation of blood vessels that shunt arterial blood directly into veins without passing through the CAPILLARIES. They usually are crooked, dilated, and with thick vessel walls. A common type is the congenital arteriovenous fistula. The lack of blood flow and oxygen in the capillaries can lead to tissue damage in the affected areas.
http://purl.obolibrary.org/obo/SCDO_0000521	deprecated Hemoglobin C-Beta Thalassemia	http://purl.obolibrary.org/obo/SCDO_0000272	obsolete Compound Heterozygous Hemoglobinopathy		'A form of beta-thalassemia with a phenotype of mild to moderate hemolytic anemia. Patients are often asymptomatic but if present symptoms include anemia and enlarged spleen.'
http://purl.obolibrary.org/obo/SCDO_0001765	Beta-Minus Thalassemia Mutation	http://purl.obolibrary.org/obo/SCDO_0009731	Beta Thalassemia Mutation		A mutation in the beta-globin gene, HBB, that results in reduced beta globin synthesis.
http://purl.obolibrary.org/obo/SCDO_0001064	Sickle Cell Disease-S/O-Arab	http://purl.obolibrary.org/obo/SCDO_1000163	Compound Heterozygous Sickle Cell Disease		One of the sickle cell disorders characterized by the presence of both hemoglobin S and hemoglobin O-Arab. It can cause anemia, repeated infections, and periodic episodes of pain and organ damage.
http://purl.obolibrary.org/obo/SCDO_0000107	Beliefs About Causes of Illness	http://purl.obolibrary.org/obo/SCDO_0000488	Health Beliefs		Personal or collective understanding of what the causes (could be predisposing factors, enabling factors, precipitating factors, reinforcing factors, and/or risk factors) are of a certain illness.
http://purl.obolibrary.org/obo/SCDO_0000966	Rapid Estimate of Adolescent Literacy in Medicine (REALM-Teen)	http://purl.obolibrary.org/obo/SCDO_0000953	Quality of Life Measure		The Rapid Estimate of Adolescent Literacy or REALM-Teen is a valid, reliable, easy-to-administer tool that will allow health professionals to screen youth in grades 6-12 for below-grade reading. The REALM-Teen is a reading recognition instrument, modeled after the Rapid Estimate of Adult Literacy in Medicine (REALM), the most commonly used tool to screen adults for low literacy in health care settings. The REALM-Teen is a reading recognition instrument which measures an individual's ability to pronounce words in ascending order of difficulty. All test words are commonly used adolescent health terms.
http://purl.obolibrary.org/obo/SCDO_0000849	Arterial Oxygen Saturation	http://purl.obolibrary.org/obo/CMO_0001324	Oxygen Saturation		The amount of oxygen bound to hemoglobin in arterial blood expressed as a percentage of the maximal binding capacity, as determined by an arterial blood gas test.
http://purl.obolibrary.org/obo/SCDO_1000315	Serum HDL Cholesterol Test	http://purl.obolibrary.org/obo/SCDO_0000133	Blood Test		A quantitative measurement of the amount of HDL cholesterol present in a sample of serum.
http://purl.obolibrary.org/obo/SCDO_0006461	Acutely Severe Anemia	http://purl.obolibrary.org/obo/HP_0001903	Anemia		Aplasia or hemolysis may be precipitated by another illness/infection in sickle cell disease patients. Acutely severe anemia is defined as Hb < 5g/dl or a recent acute drop in HB > 2g/dl below the individual's steady state value. If no steady state value is available, it can be detected by the presence of acutely symptomatic anemia (i.e. tachycardia, cardiac failure, shock).
http://purl.obolibrary.org/obo/SCDO_0000539	Hemoglobin Lepore Trait	http://purl.obolibrary.org/obo/SCDO_0000551	Thalassemia Trait		The inheritance of the gene for hemoglobin Lepore from one parent and a gene for normal adult hemoglobin (hemoglobin A) from the other parent.
http://purl.obolibrary.org/obo/SCDO_0000780	deprecated Musculoskeletal System	http://purl.obolibrary.org/obo/SCDO_0001336	from phenotype		Anatomical system that consists of the muscular and skeletal systems.
http://purl.obolibrary.org/obo/SCDO_1000157	Quality of Life Related Personal Attribute	http://purl.obolibrary.org/obo/NCIT_C17047	Quality of Life		The distinguishing qualities or prominent aspects of an individual person that have some relation with quality of life.
http://purl.obolibrary.org/obo/SCDO_0000195	Causal Adverse Drug Event Due to SNP	http://purl.obolibrary.org/obo/SCDO_0000194	Causal Adverse Drug Event Due to Genetic Predisposition		A causal adverse drug event due to genetic predisposition that is specifically induced by SNP.
http://purl.obolibrary.org/obo/SCDO_0000492	Health Records	http://purl.obolibrary.org/obo/SCDO_0000738	Medical Records		Health data accessible to the patient and others.
http://purl.obolibrary.org/obo/SCDO_0000307	Current Marital Status	http://purl.obolibrary.org/obo/NCIT_C16495	Demographic Factor		The respondent's current marital status.
http://purl.obolibrary.org/obo/CHMO_0001009	High-Performance Liquid Chromatography	http://purl.obolibrary.org/obo/SCDO_1000577	Type of SCD Test		Column chromatography where the mobile phase is a liquid, the stationary phase consists of very small particles and the inlet pressure is relatively high.
http://purl.obolibrary.org/obo/CHMO_0002580	Colorimetric Test	http://purl.obolibrary.org/obo/SCDO_0000120	Biochemical Assay		A test which produces colour change in the sample.
http://purl.obolibrary.org/obo/HP_0025435	Increased Lactate Dehydrogenase Level	http://purl.obolibrary.org/obo/HP_0045040	Abnormal Lactate Dehydrogenase Level		An elevated level of the enzyme lactate dehydrogenase in serum.
http://purl.obolibrary.org/obo/NCIT_C102988	Patient Reported Outcomes Measurement Information System (PROMIS)	http://purl.obolibrary.org/obo/SCDO_1000297	Quality of Life and Care Diagnostic Instrument		A project to develop standards for the collection and analysis of patient-reported health status data using a system of highly reliable, precise measures for physical, mental, and social well-being. Patients are asked a series of rigorously reviewed questions covering common domains and metrics across differing conditions and treatments. The questions can be administered in short forms or adaptively through computerized adaptive testing and reports can be generated to allow clinicians to better understand how treatments might affect the quality of life of their patients.
http://purl.obolibrary.org/obo/NCIT_C103165	Subject Visit Type	http://purl.obolibrary.org/obo/EUPATH_0000310	Information on Observation Details		The kind of visit undertaken by the subject within a study, such as inpatient, outpatient, telephone, etc.
http://purl.obolibrary.org/obo/NCIT_C103270	Waiver of Consent	http://purl.obolibrary.org/obo/SCDO_1000462	Research Ethics Committee Decision		The release from the requirement to obtain informed consent during a study that is granted by Human Subject Protection committee for a research institution for a protocol that is being reviewed by the Institutional Review Board.
http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group	http://purl.obolibrary.org/obo/SCDO_0001551	Ethnolinguistics		A social group characterized by a distinctive social and cultural tradition that is maintained from generation to generation. Members share a common history and origin and a sense of identification with the group. They have similar and distinctive features in their lifestyle habits and shared experiences. They often have a common genetic heritage which may be reflected in their experience of health and disease.
http://purl.obolibrary.org/obo/NCIT_C17049	Race	http://purl.obolibrary.org/obo/NCIT_C16495	Demographic Factor		An arbitrary classification of a taxonomic group that is a division of a species. It usually arises as a consequence of geographical isolation within a species and is characterized by shared heredity, physical attributes and behavior, and in the case of humans, by common history, nationality, or geographic distribution.
http://purl.obolibrary.org/obo/NCIT_C78652	Pediatric Quality of Life Inventory (PedsQL)	http://purl.obolibrary.org/obo/SCDO_0000952	Quality of Life in Sickle Cell Disease Measure		A parent report or patient self report for measuring health-related quality of life (HRQOL) in healthy children and adolescents and those with acute and chronic health conditions. The PedsQL Measurement Model uses a modular approach that integrates both generic core scales and disease-specific modules into one measurement system. (Copyright 1998-2008 James W. Varni, Ph.D.)
http://purl.obolibrary.org/obo/NCIT_C113340	Secondary Amenorrhea	http://purl.obolibrary.org/obo/HP_0000080	Abnormality of Reproductive System Physiology		The cessation of menstruation for six months or more in a female that is not pregnant, breastfeeding or menopausal.
http://purl.obolibrary.org/obo/NCIT_C114300	Carboxyhemoglobin	http://purl.obolibrary.org/obo/NCIT_C16676	Hemoglobin		Hemoglobin where the heme group has formed a stable complex with carbon monoxide (CO). This complex is produced after CO has been inhaled or as a byproduct of hemoglobin, protoporphyrin or dichloromethane catabolism. The heme-CO complex is approximately 200 times more stable than heme-oxygen complexes. Thus, high levels of carboxyhemoglobin in the circulation can lead to tissue hypoxia and death.
http://purl.obolibrary.org/obo/NCIT_C114714	Dialysis Membrane Reaction	http://purl.obolibrary.org/obo/NCIT_C78254	Device Complication		A severe hypersensitivity-like reaction occurring during dialysis due to exposure to the dialysis membrane.
http://purl.obolibrary.org/obo/NCIT_C114717	Dialysis Catheter Fracture	http://purl.obolibrary.org/obo/NCIT_C78254	Device Complication		A crack or break in a dialysis catheter caused by material weakness or mechanical compression.
http://purl.obolibrary.org/obo/NCIT_C116081	Dialysis Access Complication	http://purl.obolibrary.org/obo/NCIT_C2959	Complication		Any issue that arises as a consequence of a problem with a patient's dialysis access.
http://purl.obolibrary.org/obo/NCIT_C16809	Magnetic Resonance Imaging	http://purl.obolibrary.org/obo/OBI_0000185	Imaging Assay		Imaging that uses radiofrequency waves and a strong magnetic field rather than x-rays to provide amazingly clear and detailed pictures of internal organs and tissues. The technique is valuable for the diagnosis of many pathologic conditions, including cancer, heart and vascular disease, stroke, and joint and musculoskeletal disorders.
http://purl.obolibrary.org/obo/NCIT_C27088	Hyperbilirubinemia	http://purl.obolibrary.org/obo/HP_0032180	Abnormal Circulating Metabolite Concentration		Abnormally high level of bilirubin in the blood. Excess bilirubin is associated with jaundice.
http://purl.obolibrary.org/obo/NCIT_C2890	Bacterial Infection	http://purl.obolibrary.org/obo/IDO_0000586	Infection		An acute infectious disorder caused by gram positive or gram negative bacteria. Representative examples include pneumococcal, streptococcal, salmonella and meningeal infections.
http://purl.obolibrary.org/obo/NCIT_C29091	Hepatitis B Vaccine	http://purl.obolibrary.org/obo/VO_0000001	Vaccine		A non-infectious mixture containing recombinant hepatitis B surface antigen (HBsAg) in a liquid vehicle. Immunization with the hepatitis B vaccine induces the formation of specific anti-hepatitis B antibodies and an active immunity against hepatitis B infection.
http://purl.obolibrary.org/obo/NCIT_C3890	Hypoxia	http://purl.obolibrary.org/obo/HP_0002086	Abnormality of the Respiratory System		A decrease in the amount of oxygen in the body. Symptoms range from mild (impaired judgment, memory loss, impaired motor coordination) to severe (seizures and coma). In SCD patients, this is considered as saturated oxygen < 95% on air.
http://purl.obolibrary.org/obo/NCIT_C49131	Diagnostic Histology Test	http://purl.obolibrary.org/obo/SCDO_0000902	Physiological Assay		A diagnostic test used to examine and define microscopic tissue structure, composition, or etiology. The test results are often used by a clinician to diagnose disease or disordered function.
http://purl.obolibrary.org/obo/NCIT_C519	Gentamicin	http://purl.obolibrary.org/obo/NCIT_C258	Antibiotic		A broad-spectrum aminoglycoside antibiotic produced by fermentation of Micromonospora purpurea or M. echinospora. Gentamicin is an antibiotic complex consisting of four major (C1, C1a, C2, and C2a) and several minor components. This agent irreversibly binds to the bacterial 30S ribosomal subunit. Specifically, this antibiotic is lodged between 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex, misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.
http://purl.obolibrary.org/obo/NCIT_C78254	Device Complication	http://purl.obolibrary.org/obo/NCIT_C2959	Complication		Any problem arising from the use of a medical device.
http://purl.obolibrary.org/obo/NCIT_C92853	Postpartum Hemorrhage	http://purl.obolibrary.org/obo/NCIT_C34941	Pregnancy Complication		Hemorrhage defined as a blood loss in excess of 500 mL after vaginal delivery or more than 1000 mL after a cesarean delivery.
http://purl.obolibrary.org/obo/NCIT_C126120	Oxygenated Hemoglobin	http://purl.obolibrary.org/obo/NCIT_C16676	Hemoglobin		Hemoglobin where the heme group has formed a reversible complex with oxygen (O2) in the lungs. This molecule is found in the systemic arteries and transports O2 from the lungs to the tissues where it is readily released.
http://purl.obolibrary.org/obo/NCIT_C126121	Deoxygenated Hemoglobin	http://purl.obolibrary.org/obo/NCIT_C16676	Hemoglobin		Hemoglobin containing a heme group that is not bound to oxygen (O2). This molecule is normally found in the systemic veins following transit through capillaries and release of O2 into the tissues. Excess deoxyhemoglobin can be associated with hypoxia.
http://purl.obolibrary.org/obo/NCIT_C1643	Polyvalent Pneumococcal Vaccine	http://purl.obolibrary.org/obo/VO_0000675	Streptococcus Pneumoniae Vaccine		An polyvalent vaccine used to prevent infection by the bacterium Streptococcus pneumoniae. Pneumococcal polyvalent vaccine contains highly purified capsular antigens from the 23 most prevalent or invasive pneumococcal types of Streptococcus pneumoniae to ensure cross-protection. Following vaccination, protective capsular type-specific antibody levels typically develop by the third week; serotype-specific antibody levels generally decline after 5-10 years.
http://purl.obolibrary.org/obo/NCIT_C16453	Community	http://purl.obolibrary.org/obo/SCDO_0001082	Social Environment		A set of people with some shared element. The substance of shared element varies widely, from geography to a situation to interest to lives and values. The term is widely used to evoke sense of collectivity.
http://purl.obolibrary.org/obo/NCIT_C16495	Demographic Factor	http://purl.obolibrary.org/obo/NCIT_C19332	Personal Attribute		The statistical characterization of human populations or segments of human populations (e.g., characterization by age, sex, race, or income).
http://purl.obolibrary.org/obo/NCIT_C16567	Exercise	http://purl.obolibrary.org/obo/NCIT_C15900	Lifestyle Therapy		Activity that requires physical or mental exertion, especially when performed to develop or maintain fitness.
http://purl.obolibrary.org/obo/NCIT_C16576	Female	http://purl.obolibrary.org/obo/NCIT_C91106	Clinical or Research Assessment Answer		A person who belongs to the sex that normally produces ova. The term is used to indicate biological sex distinctions, or cultural gender role distinctions, or both.
http://purl.obolibrary.org/obo/NCIT_C17004	Genetic Polymorphism	http://purl.obolibrary.org/obo/SCDO_0001369	Genetic Variation		The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site to large nucleotide sequences visible at a chromosomal level.
http://purl.obolibrary.org/obo/NCIT_C17047	Quality of Life	http://purl.obolibrary.org/obo/SCDO_0000950	Quality of Life and Care		The subjective measurement of an individual's sense of well-being and ability to enjoy life. The concept holds varying meanings for different people and may evolve over time. For some individuals it implies autonomy, empowerment, capability, and choice; for others, security, social integration, or freedom from stress or illness.
http://purl.obolibrary.org/obo/NCIT_C17357	Gender	http://purl.obolibrary.org/obo/NCIT_C16495	Demographic Factor		The assemblage of properties that distinguish people on the basis of the societal roles expected for the two sexes.
http://purl.obolibrary.org/obo/NCIT_C17655	Reproductive History	http://purl.obolibrary.org/obo/NCIT_C18772	Personal Medical History		An account of all reproductive events and problems a person has experienced. An important aggregate factor in epidemiological studies of women's health. The concept usually includes the number and timing of pregnancies and their outcomes, the incidence of breast feeding, and may include age of menarche and menopause, regularity of menstruation, fertility, gynecological or obstetric problems, or contraceptive usage.
http://purl.obolibrary.org/obo/NCIT_C17873	Psychosocial Effect	http://purl.obolibrary.org/obo/SCDO_0000746	Mental Health		Having to do with the physical, psychological, cognitive, and social consequences of disease, including stigmatization of persons affected.
http://purl.obolibrary.org/obo/NCIT_C18133	Missense Mutation	http://purl.obolibrary.org/obo/NCIT_C62200	Point Mutation		A single base pair substitution that alters the genetic code in a way that produces an amino acid that is different from the usual amino acid at that position. Some missense mutations will alter the function of the protein.
http://purl.obolibrary.org/obo/NCIT_C18772	Personal Medical History	http://purl.obolibrary.org/obo/SCDO_1000157	Quality of Life Related Personal Attribute		A record of a patient's background regarding health and the occurrence of disease events of the individual. In addition, personal medical history may be a variable in epidemiologic studies.
http://purl.obolibrary.org/obo/NCIT_C19228	Optical Instrument	http://purl.obolibrary.org/obo/OBI_0400169	Microscope		An instrument used to measure an event involving emission, absorption, or refraction of light.
http://purl.obolibrary.org/obo/NCIT_C19296	Deletion Mutation	http://purl.obolibrary.org/obo/IDOMAL_50000026	Mutation		Any rearrangement to the genomic content that results in the loss of one or more nucleotides of DNA. Deletions are generally irreversible rearrangements. They may alter the reading frame of a gene, or may result in loss of large chromosomal regions.
http://purl.obolibrary.org/obo/NCIT_C39796	Ethics	http://purl.obolibrary.org/obo/SCDO_0006339	Research		The philosophical study of moral values and rules. Ethics is a general term for what is often described as the "science of morality". The Western tradition of ethics is sometimes called moral philosophy. This is one of the three major branches of philosophy, alongside metaphysics and logic.
http://purl.obolibrary.org/obo/NCIT_C62200	Point Mutation	http://purl.obolibrary.org/obo/IDOMAL_50000026	Mutation		A small scale mutation caused by the substitution of a single nucleotide for another nucleotide.
http://purl.obolibrary.org/obo/NCIT_C96391	Meningococcal Conjugate Vaccine MCV4	http://purl.obolibrary.org/obo/VO_0000001	Vaccine		A conjugate vaccine of meningococcal polysaccharide used for active immunization against invasive meningococcal disease caused by Neisseria meningiditis serogroups A, C, Y, and W-135.
http://purl.obolibrary.org/obo/NCIT_C97120	Pneumococcal 10-Valent Conjugate Vaccine	http://purl.obolibrary.org/obo/NCIT_C97123	Conjugate Pneumococcal Vaccine		An active immunizing vaccine used to prevent infection by the bacterium Streptococcus pneumoniae. It is indicated for disease caused by serotypes 1, 5, 4, 6B, 7, 9V, 14, 18C, 19F, and 23F.
http://purl.obolibrary.org/obo/NCIT_C97121	Pneumococcal 13-Valent Conjugate Vaccine	http://purl.obolibrary.org/obo/NCIT_C97123	Conjugate Pneumococcal Vaccine		A pneumococcal conjugate vaccine containing 13 different strains of the bacterium Streptococcus pneumoniae, used in children and studied in immunocompromised patients for the prevention of pneumococcal disease. The pneumococcal 13-valent conjugate vaccine contains capsular antigen polysaccharides derived from the S. pneumoniae serotypes 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F that are individually conjugated to a nontoxic diphtheria cross-reactive material (CRM) carrier protein (CRM197). Upon vaccination, pneumococcal 13-valent conjugate vaccine induces active immunization against 13 different serotypes of S. pneumoniae and protects against pneumococcal disease.
http://purl.obolibrary.org/obo/NCIT_C98835	Sickle Cell Disease-S Beta Zero Thalassemia	http://purl.obolibrary.org/obo/NCIT_C95539	Sickle Beta Thalassemia		A form of sickle cell thalassemia characterized by the absence of hemoglobin A. Patients usually have severe anemia identical to that seen in sickle cell disease.
http://purl.obolibrary.org/obo/SCDO_0000685	Leg Ulcer	http://purl.obolibrary.org/obo/HP_0200042	Skin Ulcer		Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (varicose ulcer), 5% to arterial disease, and the remaining 5% to other causes.
http://purl.obolibrary.org/obo/SCDO_1000320	Cigarette Smoking Status Diagnostic Instrument - Adult	http://purl.obolibrary.org/obo/SCDO_1000319	Cigarette Smoking Status Diagnostic Instrument		Questions asking an adult respondent about smoking status in his or her entire life.
http://purl.obolibrary.org/obo/SCDO_0000505	Hematology Screening Test	http://purl.obolibrary.org/obo/SCDO_0000133	Blood Test		A test to detect potential blood disorders or diseases in people who do not have any symptoms of disease.
http://purl.obolibrary.org/obo/SCDO_0001041	Seroepidemiologic Studies	http://purl.obolibrary.org/obo/SCDO_0000437	Epidemiologic Studies		Epidemiologic studies based on the detection through serological testing of characteristic change in the serum level of specific antibodies. Latent subclinical infections and carrier states can thus be detected in addition to clinically overt cases.
http://purl.obolibrary.org/obo/SCDO_0000424	Electrophoresis	http://purl.obolibrary.org/obo/SCDO_0000216	Chemical Assay		An electrochemical process in which macromolecules or colloidal particles with a net electric charge migrate in a solution under the influence of an electric current.
http://purl.obolibrary.org/obo/DOID_0111033	African Iron Overload	http://purl.obolibrary.org/obo/SCDO_1000281	Secondary Hemochromatosis		A hemochromatosis characterized by a predisposition to iron loading that is exacerbated by excessive intake of dietary iron, commonly related to consumption of tradition beer brewed in non-galvanized steel drums.
http://purl.obolibrary.org/obo/HP_0020054	Abnormal Erythrocyte Physiology	http://purl.obolibrary.org/obo/HP_0001871	Abnormality of Blood and Blood-Forming Tissues		Any functional abnormality of erythrocytes (red-blood cells).
http://purl.obolibrary.org/obo/HP_0032180	Abnormal Circulating Metabolite Concentration	http://purl.obolibrary.org/obo/MP_0009642	Abnormal Blood Homeostasis		An abnormal level of an analyte measured in the blood.
http://purl.obolibrary.org/obo/SCDO_0000466	Haptoglobin Blood Test	http://purl.obolibrary.org/obo/SCDO_0000133	Blood Test		A bioassay to measure haptoglobin, which is produced by the liver and transports hemoglobin to the liver for recycling.
http://purl.obolibrary.org/obo/SCDO_0000073	Artesunate	http://purl.obolibrary.org/obo/SCDO_0001129	Supportive Therapeutics		A water-soluble, semi-synthetic derivative of the sesquiterpene lactone artemisinin with anti-malarial, anti-schistosomiasis, antiviral, and potential anti-neoplastic activities.
http://purl.obolibrary.org/obo/SCDO_0001135	Acute Sickle Cell Crisis	http://purl.obolibrary.org/obo/SCDO_1000000	Acute Phenotype		Refers to a worsening, over a short period of time, of the symptoms and signs of SCD; usually associated with pain and/or shortage of blood (anaemia). Can be suspected in a person with sickle cell disease who presents with a sudden onset of pain, infection, anemia or other symptoms such as stroke or priapism. Acute pain frequently occurs spontaneously, but may be precipitated by infections, skin cooling, dehydration or stress.
http://purl.obolibrary.org/obo/ICO_0000157	Parental Consent	http://purl.obolibrary.org/obo/SCDO_0007087	Informed Consent		An informed consent by the parent/guardian of a child or a minor to consent to give permission for the child/minor to be included in research.
http://purl.obolibrary.org/obo/HP_0500015	Abnormal Cardiac Test	http://purl.obolibrary.org/obo/HP_0001626	Abnormality of Cardiovascular System		Abnormal test result of cardiovascular physiology.
http://purl.obolibrary.org/obo/HP_0020058	Abnormal Red Blood Cell Count	http://purl.obolibrary.org/obo/HP_0001877	Abnormal Erythrocyte Morphology		Any deviation from the normal number of red blood cells per volume in the circulation.
http://purl.obolibrary.org/obo/HP_0020059	Increased Red Blood Cell Count	http://purl.obolibrary.org/obo/HP_0020058	Abnormal Red Blood Cell Count		An abnormal elevation above the normal number of red blood cells per volume in the circulation.
http://purl.obolibrary.org/obo/HP_0020060	Decreased Red Blood Cell Count	http://purl.obolibrary.org/obo/HP_0020058	Abnormal Red Blood Cell Count		An abnormal reduction below the normal number of red blood cells per volume in the circulation.
http://purl.obolibrary.org/obo/HP_0020061	Abnormal Hemoglobin Concentration	http://purl.obolibrary.org/obo/SCDO_0009613	Protein Phenotype		Any deviation from the normal concentration of hemoglobin in the blood.
http://purl.obolibrary.org/obo/HP_0020062	Decreased Hemoglobin Concentration	http://purl.obolibrary.org/obo/HP_0020061	Abnormal Hemoglobin Concentration		An abnormal reduction below normal hemoglobin concentration in the circulation.
http://purl.obolibrary.org/obo/HP_0020063	Increased Hemoglobin Concentration	http://purl.obolibrary.org/obo/HP_0020061	Abnormal Hemoglobin Concentration		An abnormal elevation above normal hemoglobin concentration in the circulation.
http://purl.obolibrary.org/obo/OPMI_0000023	Yes	http://purl.obolibrary.org/obo/NCIT_C91106	Clinical or Research Assessment Answer		An answer to question where the answer is Yes.
http://purl.obolibrary.org/obo/OPMI_0000024	No	http://purl.obolibrary.org/obo/NCIT_C91106	Clinical or Research Assessment Answer		An answer to question where the answer is No.
http://purl.obolibrary.org/obo/OPMI_0000025	Do Not Know	http://purl.obolibrary.org/obo/NCIT_C91106	Clinical or Research Assessment Answer		An answer to question that indicates the response to the specified question is unknown.
http://purl.obolibrary.org/obo/OPMI_0000027	Refused	http://purl.obolibrary.org/obo/NCIT_C91106	Clinical or Research Assessment Answer		An answer to question where one declines to answer the specified question.
http://purl.obolibrary.org/obo/OPMI_0000028	Other	http://purl.obolibrary.org/obo/NCIT_C91106	Clinical or Research Assessment Answer		An answer to question that is not enumerated in the list and then may be entered with free text in a separate text box
http://purl.obolibrary.org/obo/SCDO_1000342	History of Transfusion Diagnostic Instrument	http://purl.obolibrary.org/obo/NCIT_C91105	Clinical or Research Assessment Questionnaire		A questionnaire to assess history of transfusion.
http://purl.obolibrary.org/obo/SCDO_0001034	Self Care	http://purl.obolibrary.org/obo/SCDO_0000978	Rehabilitation		Caring for self when ill or positive actions and adopting behaviors to prevent illness.
http://purl.obolibrary.org/obo/SCDO_0001061	Sickle Cell Disease-S/D-Punjab	http://purl.obolibrary.org/obo/NCIT_C155310	Sickle Cell Disease-SD		A rare compound heterozygous hemoglobinopathy characterised by the presence of two beta globin gene variants: that of hemoglobin S (beta-6(GAG-->GTG)) and that of hemoglobin D-Punjab (beta-121(GAA-->CAA)).
http://purl.obolibrary.org/obo/NCIT_C38085	Pulse Oximetry	http://purl.obolibrary.org/obo/SCDO_0000942	Pulmonary Function Test		A non-invasive method that provides estimates of arterial oxyhemoglobin saturation by utilizing selected wavelengths of light to determine the saturation of oxyhemoglobin.
http://purl.obolibrary.org/obo/NCIT_C38141	Pneumococcal 7-Valent Conjugate Vaccine	http://purl.obolibrary.org/obo/NCIT_C97123	Conjugate Pneumococcal Vaccine		An active immunizing agent used to prevent infection by the bacterium Streptococcus pneumoniae. Pneumococcal 7-valent conjugate vaccine consists of a solution of saccharides of the capsular antigens of Streptococcus serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F individually conjugated to diphtheria CRM 197 protein.
http://purl.obolibrary.org/obo/NCIT_C3833	Asymptomatic	http://purl.obolibrary.org/obo/OGMS_0000023	Phenotype		Without clinical signs or indications that raise the possibility of a particular disorder or dysfunction.
http://purl.obolibrary.org/obo/NCIT_C38698	Hyperviscosity	http://purl.obolibrary.org/obo/HP_0001871	Abnormality of Blood and Blood-Forming Tissues		An increase in the viscosity of blood resulting from an increase in the proportion of cellular elements of the blood, a change in the mechanical properties of the cellular elements of the blood, and/or an alteration in plasma viscosity.
http://purl.obolibrary.org/obo/NCIT_C39547	Treatment Efficacy	http://purl.obolibrary.org/obo/NCIT_C43646	Association		The probability of benefit to individuals in a defined population from a medical technology applied for a given medical problem under ideal conditions of use. Efficacy is a measure of effect of therapy among appropriate patients in whom treatment is tolerated and effectively administered, under the condition of sufficient patients' compliance, usually determined in randomized trials.
http://purl.obolibrary.org/obo/NCIT_C40438	Beck Depression Inventory-II (BDI-II)	http://purl.obolibrary.org/obo/SCDO_1000297	Quality of Life and Care Diagnostic Instrument		The BDI-II is the most widely used instrument for measuring depression. It consists of 21 items to assess the intensity of depression in clinical and normal patients. Each item is a list of four statements arranged in increasing severity about a particular symptom of depression, and rated on a scale of 0 to 3.
http://purl.obolibrary.org/obo/NCIT_C40978	Telephone Number	http://purl.obolibrary.org/obo/NCIT_C19332	Personal Attribute		A sequence of decimal digits (0-9) that is used for identifying a destination telephone line or other device in a telephone network.
http://purl.obolibrary.org/obo/NCIT_C95534	Hemoglobin Trait	http://purl.obolibrary.org/obo/SCDO_0000552	Hemoglobinopathy		A condition in which a person is heterozygous for a globin gene, with one normal allele and one defective allele.
http://purl.obolibrary.org/obo/NCIT_C97123	Conjugate Pneumococcal Vaccine	http://purl.obolibrary.org/obo/VO_0000675	Streptococcus Pneumoniae Vaccine		An active immunizing vaccine used to prevent infection by the bacterium Streptococcus pneumoniae. It consists of a solution of saccharides of the capsular antigens of Streptococcus serotypes individually conjugated to proteins.
http://purl.obolibrary.org/obo/NCIT_C92755	Chorionic Villus Sampling	http://purl.obolibrary.org/obo/SCDO_0000919	Prenatal Screening for Sickle Cell		The biopsy of placental tissue containing the chorionic villi from the maternal uterus in early pregnancy to diagnose fetal genetic defects.
http://purl.obolibrary.org/obo/SCDO_0000098	Bacteria	http://purl.obolibrary.org/obo/OBI_0000925	Infectious Agent		One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to oxygen: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or phototrophy (via light reaction); for chemotrophs by their source of chemical energy: chemolithotrophy (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for carbon; nitrogen; etc.; heterotrophy (from organic sources) or autotrophy (from carbon dioxide). They can also be classified by whether or not they stain (based on the structure of their cell walls) with crystal violet dye: gram-negative or gram-positive.
http://purl.obolibrary.org/obo/SCDO_0000728	Diagnostic Measurement	http://purl.obolibrary.org/obo/SCDO_0000379	Diagnostics		An information entity used in the diagnosis of medical conditions. It could be the recording of the output of a diagnostic device or the outcome of a diagnostic tool.
http://purl.obolibrary.org/obo/SYMP_0000412	Anxiety	http://purl.obolibrary.org/obo/SCDO_0000954	Quality of Life Related SCD Symptoms and Complications		A neurological and physiological symptom characterized by a painful or apprehensive uneasiness of mind usually over an impending or anticipated ill.
http://purl.obolibrary.org/obo/SYMP_0019161	Muscle Pain	http://purl.obolibrary.org/obo/SCDO_0000851	Pain		Muscle pain is a pain characterized by pain in one or more muscles.
http://purl.obolibrary.org/obo/VO_0000675	Streptococcus Pneumoniae Vaccine	http://purl.obolibrary.org/obo/VO_0000001	Vaccine		A Streptococcal vaccine that is used against S. pneumoniae infection, which causes pneumococcal diseases.
http://purl.obolibrary.org/obo/ICO_0000036	Date of Signing Consent	http://purl.obolibrary.org/obo/SCDO_1000522	Temporal Observable of Consent		A date specification that designates when an informed consent form was signed.
http://purl.obolibrary.org/obo/NCIT_C41129	deprecated Region	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		An area or portion of something with more or less definite boundaries designed or specified according to some established biological, administrative, economic, demographic, etc. criteria.
http://purl.obolibrary.org/obo/NCIT_C42559	Degree Celsius	http://purl.obolibrary.org/obo/UO_0000005	Temperature Unit		A unit of temperature of the temperature scale designed so that the freezing point of water is 0 degrees and the boiling point is 100 degrees at standard atmospheric pressure. The current official definition of the Celsius sets 0.01 C to be at the triple point of water and a degree to be 1/273.16 of the difference in temperature between the triple point of water and absolute zero. One degree Celsius represents the same temperature difference as one Kelvin.
http://purl.obolibrary.org/obo/NCIT_C62198	Nonsense Mutation	http://purl.obolibrary.org/obo/NCIT_C62200	Point Mutation		A point mutation occurring within the protein-coding region of a gene, and which codes for a stop that can truncate the protein.
http://purl.obolibrary.org/obo/NCIT_C561	Ibuprofen	http://purl.obolibrary.org/obo/CHEBI_35475	Non-Steroidal Anti-Inflammatory Drug		A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation.
http://purl.obolibrary.org/obo/CMO_0002876	N-Terminal Pro-Brain Natriuretic Peptide Level	http://purl.obolibrary.org/obo/CMO_0000023	Blood Chemistry Measurement		The amount of N-terminal (NT)-pro hormone BNP (Nppb) in a specified volume of blood.
http://purl.obolibrary.org/obo/NCIT_C154481	Adult Sickle Cell Quality-of-Life Measurement Information System (ASCQ-Me)	http://purl.obolibrary.org/obo/SCDO_0000952	Quality of Life in Sickle Cell Disease Measure		A patient-reported outcome measurement system designed to evaluate and monitor the physical, mental, and social well-being of adults with sickle cell disease.
http://purl.obolibrary.org/obo/NCIT_C154865	Cerebral Blood Flow Assay	http://purl.obolibrary.org/obo/SCDO_1000316	Blood Flow Test		An evaluation of the perfusion of blood through the brain.
http://purl.obolibrary.org/obo/NCIT_C155310	Sickle Cell Disease-SD	http://purl.obolibrary.org/obo/SCDO_1000163	Compound Heterozygous Sickle Cell Disease		A variant of sickle cell disease due to heterozygosity for hemoglobin S and hemoglobin D mutations. Patients present with the symptoms of sickle cell disease but the symptoms are less frequent and severe compared to patients with hemoglobin SS disease.
http://purl.obolibrary.org/obo/NCIT_C155312	Sickle Cell Chronic Lung Disease	http://purl.obolibrary.org/obo/SCDO_0000895	Phenotype of Sickle Cell Disease		A pulmonary complication of sickle cell disease characterized by radiographic interstitial abnormalities and impaired pulmonary function. In severe cases, pulmonary hypertension is present.
http://purl.obolibrary.org/obo/NCIT_C155932	Global Mental Status Screener - Older Children and Adolescents	http://purl.obolibrary.org/obo/SCDO_0000455	Global Mental Status Screener		A clinician-assessed rating of psychological and social functioning in children ages six to seventeen that was developed by Shaffer et al. in 1983. The numerical scale, which is an adaptation of the adult Global Assessment Scale (GAS) developed by Endicott et al in 1976, is scored from 0 to 100 based on behaviors and life situations that are applicable to children.
http://purl.obolibrary.org/obo/HP_0025636	Endometritis	http://purl.obolibrary.org/obo/HP_0000078	Abnormality of the Genital System		Local accumulation of fluid, plasma proteins, and leukocytes in the endometrium.
http://purl.obolibrary.org/obo/SCDO_0000251	Clinical Phenotype of Beta Thalassemia	http://purl.obolibrary.org/obo/SCDO_0000111	Beta Thalassemia		Abnormal clinical manifestations of beta thalassemia that are as a result of the underlying genotype.
http://purl.obolibrary.org/obo/EUPATH_0021227	Blood Urea Concentration	http://purl.obolibrary.org/obo/CMO_0000023	Blood Chemistry Measurement		A scalar measurement datum of the concentration of urea in blood that is a specified output of a blood test.
http://purl.obolibrary.org/obo/SCDO_1000050	Hemoglobin Genotype S/D-Punjab	http://purl.obolibrary.org/obo/SCDO_1000054	Hemoglobin Genotype SD		Compound heterozygosity for the hemoglobin S (HBB Glu6Val) and hemoglobin D-Punjab (HBB Glu121Gln) variants.
http://purl.obolibrary.org/obo/SCDO_0001111	Stroke	http://purl.obolibrary.org/obo/SCDO_1000037	Abnormality of the Cerebral Vasculature		A group of pathological conditions characterized by sudden loss of neurological function due to brain ischemia or intracranial hemorrhages. Stroke is classified by the type of tissue necrosis, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature.
http://purl.obolibrary.org/obo/SCDO_1000113	HBB, GLU22VAL	http://purl.obolibrary.org/obo/SCDO_0002305	Hemoglobin D Disease Causal Mutation		A mutation where the glutamic acid in position 22 in the primary sequence of a beta-chain produced by the HBB gene is replaced by valine.
http://purl.obolibrary.org/obo/SCDO_0000423	Electronic Health Records	http://purl.obolibrary.org/obo/SCDO_0000492	Health Records		Media that facilitate transportability of pertinent information concerning patient's illness across varied providers and geographic locations. Some versions include direct linkages to online consumer health information that is relevant to the health conditions and treatments related to a specific patient.
http://purl.obolibrary.org/obo/SCDO_1000297	Quality of Life and Care Diagnostic Instrument	http://purl.obolibrary.org/obo/SCDO_1000033	Diagnostic Instrument		A diagnostic instrument that involves an assessment of quality of life- and/or quality of care-related elements.
http://purl.obolibrary.org/obo/SCDO_0000490	Health Insurance Coverage	http://purl.obolibrary.org/obo/NCIT_C16495	Demographic Factor		Whether the respondent is covered by health insurance or some other form of health care coverage at the time of the interview.
http://purl.obolibrary.org/obo/SCDO_0000383	obsolete Diffusion Capacity by Biochemical Methods	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		
http://purl.obolibrary.org/obo/SCDO_0000516	deprecated Hemoglobin A2 Profile	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		
http://purl.obolibrary.org/obo/SCDO_0000542	obsolete - Hemoglobin M Trait	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		
http://purl.obolibrary.org/obo/SCDO_0001374	obsolete heterozygous beta c mutation	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		
http://purl.obolibrary.org/obo/SCDO_0001375	obsolete homozygous beta c mutation	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		
http://purl.obolibrary.org/obo/SCDO_1000212	deprecated Disease Caused by A/Jamaica Plain Genotype	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		
http://purl.obolibrary.org/obo/SCDO_1000213	deprecated Disease Caused by A/S-Oman Genotype	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		
http://purl.obolibrary.org/obo/SCDO_1000214	deprecated Disease Caused by C/S Antilles Genotype	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		
http://purl.obolibrary.org/obo/SCDO_1000234	obsolete - Hemoglobin M trait Genotype	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		
http://purl.obolibrary.org/obo/SCDO_1000477	deprecated Field Type	http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms		
http://purl.obolibrary.org/obo/SCDO_0000766	obsolete Modifying the Home Environment and Making it Safer For the Patient	http://purl.obolibrary.org/obo/SCDO_1000035	from therapeutics		
http://purl.obolibrary.org/obo/SCDO_1000398	BCL11A Erythroid Enhancer	http://purl.obolibrary.org/obo/SCDO_1000396	Gene Enhancer		
http://purl.obolibrary.org/obo/SCDO_1000479	deprecated Calculation Field Type	http://purl.obolibrary.org/obo/SCDO_1000477	deprecated Field Type		
http://purl.obolibrary.org/obo/SCDO_1000480	deprecated  Checkbox Field Type	http://purl.obolibrary.org/obo/SCDO_1000477	deprecated Field Type		
http://purl.obolibrary.org/obo/SCDO_1000481	deprecated Descriptive Field Type	http://purl.obolibrary.org/obo/SCDO_1000477	deprecated Field Type		
http://purl.obolibrary.org/obo/SCDO_1000482	deprecated Dropdown Field Type	http://purl.obolibrary.org/obo/SCDO_1000477	deprecated Field Type		
http://purl.obolibrary.org/obo/SCDO_1000483	deprecated Dropdown Multiple Choice Field Type	http://purl.obolibrary.org/obo/SCDO_1000477	deprecated Field Type		
http://purl.obolibrary.org/obo/SCDO_1000484	deprecated Dropdown Single Choice Field Type	http://purl.obolibrary.org/obo/SCDO_1000477	deprecated Field Type		
http://purl.obolibrary.org/obo/SCDO_1000485	deprecated File Upload Field Type	http://purl.obolibrary.org/obo/SCDO_1000477	deprecated Field Type		
http://purl.obolibrary.org/obo/SCDO_1000486	deprecated Radio Field Type	http://purl.obolibrary.org/obo/SCDO_1000477	deprecated Field Type		
http://purl.obolibrary.org/obo/SCDO_1000487	deprecated Text Box Field Type	http://purl.obolibrary.org/obo/SCDO_1000477	deprecated Field Type		
http://purl.obolibrary.org/obo/SCDO_1000488	deprecated Notes Box Field Type	http://purl.obolibrary.org/obo/SCDO_1000477	deprecated Field Type		
http://purl.obolibrary.org/obo/SCDO_1000489	deprecated Slider - Visual Analog Scale	http://purl.obolibrary.org/obo/SCDO_1000477	deprecated Field Type		
http://purl.obolibrary.org/obo/SCDO_1000763	Type of Body Temperature	http://purl.obolibrary.org/obo/SCDO_1000576	Diagnostic Measurement Descriptor		
http://purl.obolibrary.org/obo/SCDO_1000768	Acide	http://purl.obolibrary.org/obo/SCDO_1000577	Type of SCD Test		
http://purl.obolibrary.org/obo/SCDO_1000118	Dendi	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		
http://purl.obolibrary.org/obo/SCDO_1000120	Yoa	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		
http://purl.obolibrary.org/obo/SCDO_1000121	Betamaribe	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		
http://purl.obolibrary.org/obo/SCDO_1000130	Peulh	http://purl.obolibrary.org/obo/NCIT_C16564	Ethnic Group		
http://purl.obolibrary.org/obo/SCDO_1000252	Increased Red Cell Osmotic Resistance	http://purl.obolibrary.org/obo/HP_0020054	Abnormal Erythrocyte Physiology		
http://purl.obolibrary.org/obo/SCDO_0001000	SCDO				Root of all terms in the Sickle Cell Disease Ontology, an effort of unambiguously describing all concepts and unifying up-to-date knowledge in sickle cell disease.
http://purl.obolibrary.org/obo/SCDO_0000359	deprecated terms				Terms that are no longer being used in the ontology.
http://purl.obolibrary.org/obo/SCDO_0000031	age of onset modified by	http://purl.obolibrary.org/obo/SCDO_1000005	modified by		A relationship between a phenotype and a disease modifier, where the disease modifier modifies the age of onset of the phenotype. Age of onset is defined as "The age group in which disease manifestations appear." (HPO)
http://purl.obolibrary.org/obo/SCDO_0000772	mortality modified by	http://purl.obolibrary.org/obo/SCDO_1000005	modified by		A relationship between a phenotype and a disease modifier, where the disease modifier modifies the mortality (due to the phenotype) of the SCD sufferer.
http://purl.obolibrary.org/obo/SCDO_0001139	temporal pattern modified by	http://purl.obolibrary.org/obo/SCDO_1000005	modified by		A relationship between a phenotype and a disease modifier, where the disease modifier modifies the temporal pattern of the phenotype. Temporal pattern is defined as "The speed at which disease manifestations appear and develop." (HPO)
http://purl.obolibrary.org/obo/SCDO_1000172	has causal genotype	http://purl.obolibrary.org/obo/SCDO_0000660	caused or contributed to by		A relation between a condition (hemoglobinopathy) and the genotype that causes the condition.
http://purl.obolibrary.org/obo/SCDO_1000180	manifestation of	http://purl.obolibrary.org/obo/RO_0002201	phenotype of		A relationship that holds between a phenotype (i.e. manifestation) and a condition such as a disease (hemoglobinopathy), wherein the phenotype is evidence of the condition.
http://purl.obolibrary.org/obo/SCDO_1000182	symptom of	http://purl.obolibrary.org/obo/RO_0002201	phenotype of		A relation between a phenotype that is a symptom (subjective evidence of disease perceived by the patient) and a disease.
http://purl.obolibrary.org/obo/SCDO_1000184	contributes to genotype	http://purl.obolibrary.org/obo/SCDO_1000183	causes or contributes to		A relationship between an entity (e.g. genetic variation such as mutation or specific allele) and a genotype, where the entity contributes to the genotype.
http://purl.obolibrary.org/obo/SCDO_1000196	has contributing genetic variation	http://purl.obolibrary.org/obo/SCDO_0000660	caused or contributed to by		A relation between a genotype and a genetic variation (e.g. mutation or genetic recombination), where the genetic variation contributes to the genotype.
http://purl.obolibrary.org/obo/SCDO_1000202	caused by	http://purl.obolibrary.org/obo/SCDO_0000660	caused or contributed to by		A relationship between a condition (a phenotype or disease) and an entity (e.g. environment) or condition (phenotype or disease) which could be an existing condition or an event, where the entity or second condition has a causal role for the condition being described.
http://purl.obolibrary.org/obo/SCDO_1000210	has causal or contributing genetic variation	http://purl.obolibrary.org/obo/SCDO_0000660	caused or contributed to by		A relation between a condition (disease or phenotype) or an entity (molecular phenotype) and a genetic variation (e.g. mutation or genetic recombination), where the genetic variation has some causal or contributing role that influences the condition or entity.
http://purl.obolibrary.org/obo/SCDO_1000217	causes or contributes to molecular phenotype	http://purl.obolibrary.org/obo/SCDO_1000183	causes or contributes to		A relation between an entity (genotype) and a molecular phenotype, where the entity has some causal or contributing role that influences the molecular phenotype.
http://purl.obolibrary.org/obo/SCDO_1000218	has manifestation	http://purl.obolibrary.org/obo/RO_0002200	has phenotype		A relationship that holds between a condition such as a disease (hemoglobinopathy) and a phenotype (i.e. manifestation), where the phenotype is evidence of the condition.
http://purl.obolibrary.org/obo/SCDO_1000222	causes molecular phenotype	http://purl.obolibrary.org/obo/SCDO_1000183	causes or contributes to		A relation between a genotype and a molecular phenotype, where the genotype has a causal role for the molecular phenotype.
http://purl.obolibrary.org/obo/SCDO_1000223	has causal molecular phenotype	http://purl.obolibrary.org/obo/SCDO_0000660	caused or contributed to by		A relation between a condition (disease such as a Hemoglobinopathy) and a molecular phenotype, where the molecular phenotype is evidence of the condition.
http://purl.obolibrary.org/obo/RO_0003302	causes or contributes to condition	http://purl.obolibrary.org/obo/SCDO_1000183	causes or contributes to		A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal or contributing role that influences the condition.
http://purl.obolibrary.org/obo/RO_0003303	causes condition	http://purl.obolibrary.org/obo/SCDO_1000183	causes or contributes to		A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity has some causal role for the condition.
http://purl.obolibrary.org/obo/RO_0003306	contributes to frequency of condition	http://purl.obolibrary.org/obo/SCDO_1000015	modifies		A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the entity influences the frequency of the condition in a population.
http://purl.obolibrary.org/obo/RO_0003307	ameliorates condition	http://purl.obolibrary.org/obo/SCDO_1000015	modifies		A relationship between an entity (e.g. a genotype, genetic variation, chemical, or environmental exposure) and a condition (a phenotype or disease), where the presence of the entity reduces or eliminates some or all aspects of the condition.
http://purl.obolibrary.org/obo/RO_0003309	exacerbates condition	http://purl.obolibrary.org/obo/SCDO_1000015	modifies		A relationship between an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) and a condition (a phenotype or disease), where the presence of the entity worsens some or all aspects of the condition.
http://purl.obolibrary.org/obo/RO_0003310	condition ameliorated by	http://purl.obolibrary.org/obo/SCDO_1000005	modified by		A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are reduced or eliminated by the presence of the entity.
http://purl.obolibrary.org/obo/RO_0003311	condition exacerbated by	http://purl.obolibrary.org/obo/SCDO_1000005	modified by		A relationship between a condition (a phenotype or disease) and an entity (e.g. a chemical, environmental exposure, or some form of genetic variation) where some or all aspects of the condition are worsened by the presence of the entity.
http://purl.obolibrary.org/obo/RO_0002452	has symptom	http://purl.obolibrary.org/obo/RO_0002200	has phenotype		A relation that holds between a disease or an organism and a phenotype that is a symptom (subjective evidence of disease perceived by the patient).
http://purl.obolibrary.org/obo/SCDO_1000785	code requires phenotype				A relationship between a clinical code (such as ICD10 code) and a Phenotype, where the code can only be applied in instances where the phenotype is present.
http://purl.obolibrary.org/obo/SCDO_0000469	has clinical code				A relationship between a condition (phenotype or disease) and a relevant ICD-10-CM Diagnosis Code.
http://purl.obolibrary.org/obo/SCDO_0000474	has output measurement				A relation between a device (diagnostic device) and the recording of the output (diagnostic measurement) of the device.
http://purl.obolibrary.org/obo/SCDO_0000475	uses medical device				A relation between a process (e.g. a form of therapy) and a medical device, where the medical device is used in the process.
http://purl.obolibrary.org/obo/SCDO_0000660	caused or contributed to by				A relationship between a condition (a phenotype or disease) and an entity (a genotype or genetic variation) where the entity has a causal role for the condition.
http://purl.obolibrary.org/obo/SCDO_0000663	diagnosed using tool				A relation between a phenotype that is a diagnosis and a diagnostic tool used in making the diagnosis.
http://purl.obolibrary.org/obo/SCDO_0000664	treated with				A relation between a condition (phenotype or disease) and a type of treatment or a specific treatment, where the condition can be treated with the treatment.
http://purl.obolibrary.org/obo/SCDO_0001297	has essential measure				A measure that is critical to the collection of the measure at hand or is necessary for the interpretation of results for the measure at hand. Without such information, the data collected would be incomplete or misleading.
http://purl.obolibrary.org/obo/SCDO_0001364	has mode of inheritance				A relation between a particular genotype or disorder and the pattern in which the particular genotype or disorder is passed from one generation to the next.
http://purl.obolibrary.org/obo/SCDO_1000005	modified by				A relationship between a condition (phenotype or disease), entity (aspect of quality of life) or process (therapy) and a disease modifier, where the condition, entity or process is modified by the disease modifier in some way.
http://purl.obolibrary.org/obo/SCDO_1000015	modifies				A relationship between a disease modifier and a condition (phenotype or disease), entity (aspect of quality of life) or process (therapy), where the disease modifier modifies the condition, entity or process in some way.
http://purl.obolibrary.org/obo/SCDO_1000018	treats				A relation between a type of treatment or a specific treatment and a condition (phenotype or disease), where the type of treatment or specific treatment treat the condition.
http://purl.obolibrary.org/obo/SCDO_1000171	has diagnostic device				A relation between a Diagnostic Tool (test, method, assay, etc.) or the Diagnostic Measurement obtained from such a tool and a specific Diagnostic Device, where the Diagnostic Device is used in the application of the Diagnostic Tool or to obtain the Diagnostic Measurement.
http://purl.obolibrary.org/obo/SCDO_1000175	is ICD-10-CM code type				An object property that specifies the type of an ICD-10-CM code, whether Billable or Non-Billable.
http://purl.obolibrary.org/obo/SCDO_1000183	causes or contributes to				A relationship between 'a' and 'b', where 'a' has some causal role for 'b'.
http://purl.obolibrary.org/obo/SCDO_1000188	studied in				A relation between a condition (Hemoglobinopathy) and a form of research (type of study) that the condition was studied in.
http://purl.obolibrary.org/obo/SCDO_1000189	associated via				A relation between a condition (disease or phenotype) and a type of linking association (e.g. age of onset association).
http://purl.obolibrary.org/obo/SCDO_1000190	obtained via diagnostic tool				A relationship between a diagnostic measurement and the diagnostic tool used to produce the measurement.
http://purl.obolibrary.org/obo/SCDO_1000191	used by diagnostic tool				A relationship between a diagnostic device and the diagnostic tool by which the device is used.
http://purl.obolibrary.org/obo/SCDO_1000192	uses diagnostic device				A relation between a diagnostic tool (test, method, assay, etc.) and a diagnostic device, where the diagnostic device is used in the application of the diagnostic tool.
http://purl.obolibrary.org/obo/SCDO_1000193	output of diagnostic device				A relation between a diagnostic measurement and a diagnostic device, where the diagnostic measurement is the output of the diagnostic device.
http://purl.obolibrary.org/obo/SCDO_1000194	measures				A relation between a diagnostic tool and the diagnostic measurement that it measures.
http://purl.obolibrary.org/obo/SCDO_1000199	induced by				A condition (phenotype or disease) or event (adverse event) induced by an entity (e.g. a drug) or activity (e.g. exercise).
http://purl.obolibrary.org/obo/SCDO_1000203	has risk factor				A relation between a condition (disease or phenotype) and an aspect of an individual's life (personal attribute), behavior, an environmental exposure, or an inborn or inherited characteristic that increases the likelihood of the condition.
http://purl.obolibrary.org/obo/SCDO_1000219	diagnosed by				A relation between a condition that is a diagnosis and a phenotype used in making the diagnosis.
http://purl.obolibrary.org/obo/SCDO_1000220	diagnosed using measurement				A relation between an Abnormal Phenotype that is a diagnosis and a Diagnostic Measurement or Diagnostic Device Visual Output used in making the diagnosis.
http://purl.obolibrary.org/obo/SCDO_1000525	is question type				A relationship between a Clinical or Research Assessment Data Element and a Clinical or Research Assessment Question Type.
http://purl.obolibrary.org/obo/SCDO_1000526	has answer option				A relationship between a multiple choice data element and an answer option or a group of answer options that are provided to the respondent by the data element.
http://purl.obolibrary.org/obo/SCDO_1000528	collects				A relationship between a data element and the type of information that is collected by that data element.
http://purl.obolibrary.org/obo/SCDO_1000529	min number of selections allowed				Records the minimum number of selections that a respondent is allowed to make from a list of multiple answer options provided for a data element.
http://purl.obolibrary.org/obo/SCDO_1000771	has answer standard unit				A relationship between a data element and the unit of measurement used, as a standard, for the information that is collected by the data element.
http://purl.obolibrary.org/obo/SCDO_1000772	has possible finding				A relationship between a Diagnostic Measurement and a Phenotype, where the Phenotype is a possible finding of the Diagnostic Measurement, depending on the value recorded for the Diagnostic Measurement.
http://purl.obolibrary.org/obo/SCDO_1000773	diagnosed using finding				A relationship between an Abnormal Phenotype that is a diagnosis of a condition and a Phenotype that is a finding from a Diagnostic Measurement, where the Phenotype that is a finding is used as evidence to diagnose patients with the Abnormal Phenotype that is a diagnosis.
http://purl.obolibrary.org/obo/SCDO_1000776	has LLN male				Used to record the lowest value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for males for a particular laboratory result or other quantitative parameter.
http://purl.obolibrary.org/obo/SCDO_1000777	has LLN female				Used to record the lowest value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for females for a particular laboratory result or other quantitative parameter.
http://purl.obolibrary.org/obo/SCDO_1000778	has LLN pediatric				Used to record the lowest value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for children for a particular laboratory result or other quantitative parameter.
http://purl.obolibrary.org/obo/SCDO_1000779	has ULN male				Used to record the top value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for males for a particular laboratory result or other quantitative parameter.
http://purl.obolibrary.org/obo/SCDO_1000780	has ULN female				Used to record the top value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for females for a particular laboratory result or other quantitative parameter.
http://purl.obolibrary.org/obo/SCDO_1000781	has ULN pediatric				Used to record the top value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for children for a particular laboratory result or other quantitative parameter.
http://purl.obolibrary.org/obo/SCDO_1000782	has reference range standard unit				A relationship between a Diagnostic Measurement and the Unit of Measurement used for the values provided by the data properties that specify upper (ULN) or lower (LLN) limit of normal for the Diagnostic Measurement.
http://purl.obolibrary.org/obo/SCDO_1110663	in guideline				A relation between an entity (phenotypic, therapeutic or diagnostic concept) and a guideline or directive.
http://purl.obolibrary.org/obo/RO_0002200	has phenotype				A relationship that holds between a biological entity and a phenotype. Here a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). The subject of this relationship can be an organism (where the organism has the phenotype, i.e. the qualities inhere in parts of this organism), a genomic entity such as a gene or genotype (if modifications of the gene or the genotype causes the phenotype), or a condition such as a disease (such that if the condition inheres in an organism, then the organism has the phenotype).
http://purl.obolibrary.org/obo/SCDO_1000523	has LLN				Used to record the lowest value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for particular laboratory result or other quantitative parameter.
http://purl.obolibrary.org/obo/SCDO_1000204	risk factor for				A relation between an aspect of an individual's life (personal attribute), behavior, an environmental exposure, or an inborn or inherited characteristic that increases the likelihood of a condition and the condition (disease or phenotype) that it increases the likelihood of.
http://purl.obolibrary.org/obo/SCDO_1000524	has ULN				Used to record the top value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for particular laboratory result or other quantitative parameter.
http://purl.obolibrary.org/obo/SCDO_1000530	max number of selections allowed				Records the maximum number of selections that a respondent is allowed to make from a list of multiple answer options provided for a data element.
http://purl.obolibrary.org/obo/RO_0002201	phenotype of				Inverse of "has phenotype" object property.
http://purl.obolibrary.org/obo/so#associated_with	associated with