racemate ketorolac PMID:10027870 HMDB:HMDB0014608 255.269 PMID:10593468 PMID:23088994 C15H13NO3 Reaxys:413572 PMID:23702435 0 PMID:28166217 255.08954 Wikipedia:Ketorolac ketorolaco PMID:23298250 PMID:19281996 Patent:BE856681 PMID:10223774 CHEBI:6129 rac-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid InChI=1S/C15H13NO3/c17-14(10-4-2-1-3-5-10)13-7-6-12-11(15(18)19)8-9-16(12)13/h1-7,11H,8-9H2,(H,18,19) Patent:US4089969 DrugBank:DB00465 PMID:22191998 PMID:23179562 PMID:23562034 Patent:US4347186 OZWKMVRBQXNZKK-UHFFFAOYSA-N PMID:23447046 KEGG:D08104 PMID:23126437 PMID:24112670 PMID:9549656 PMID:24022643 PMID:23653032 N12C(C(C(=O)O)CC1)=CC=C2C(=O)C3=CC=CC=C3 ketorolacum ketorolac (+-)-ketorolac PMID:23473380 rac-ketorolac CAS:74103-06-3 PMID:17456651 (+-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid A racemate comprising equimolar amounts of (R)-(+)- and (S)-(-)-5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid. While only the (S)-(-) enantiomer is a COX1 and COX2 inhibitor, the (R)-(+) enantiomer exhibits potent analgesic activity. A non-steroidal anti-inflammatory drug, ketorolac is mainly used (generally as the tromethamine salt) for its potent analgesic properties in the short-term management of post-operative pain, and in eye drops to relieve the ocular itching associated with seasonal allergic conjunctivitis. It was withdrawn from the market in many countries in 1993 following association with haemorrhage and renal failure. chebi_ontology KEGG:C07062