<?xml version="1.0"?>
<?xml-stylesheet type="text/xsl" href="https://ontobee.org/ontology/view/ADO?iri=http://purl.obolibrary.org/obo/CHEBI_7476"?>
<rdf:RDF xmlns="http://www.w3.org/2002/07/owl#"
     xml:base="http://www.w3.org/2002/07/owl"
     xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
     xmlns:owl="http://www.w3.org/2002/07/owl#"
     xmlns:oboInOwl="http://www.geneontology.org/formats/oboInOwl#"
     xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
     xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#"
     xmlns:ns2="http://purl.obolibrary.org/obo/"
     xmlns:ns4="http://purl.obolibrary.org/obo/chebi/"
     xmlns:foaf="http://xmlns.com/foaf/0.1/"
     xmlns:dc="http://purl.org/dc/elements/1.1/">
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Annotation properties
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000412"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasDbXref"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/inchi"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasRelatedSynonym"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#id"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/charge"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/smiles"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasOBONamespace"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasExactSynonym"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/inchikey"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/monoisotopicmass"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#hasAlternativeId"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/formula"/>
    <AnnotationProperty rdf:about="http://www.geneontology.org/formats/oboInOwl#inSubset"/>
    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/chebi/mass"/>
    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Datatypes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- 
    ///////////////////////////////////////////////////////////////////////////////////////
    //
    // Classes
    //
    ///////////////////////////////////////////////////////////////////////////////////////
     -->

    


    <!-- http://purl.obolibrary.org/obo/CHEBI_25698 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_25698">
        <rdfs:label>ether</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/CHEBI_7476 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/CHEBI_7476">
        <rdfs:label>naproxen</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/CHEBI_25698"/>
        <oboInOwl:hasDbXref>Patent:US4009197</oboInOwl:hasDbXref>
        <oboInOwl:id>CHEBI:7476</oboInOwl:id>
        <oboInOwl:hasDbXref>DrugBank:DB00788</oboInOwl:hasDbXref>
        <ns4:smiles>COc1ccc2cc(ccc2c1)[C@H](C)C(O)=O</ns4:smiles>
        <oboInOwl:hasDbXref>CAS:22204-53-1</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>Naproxen</oboInOwl:hasExactSynonym>
        <ns4:inchi>InChI=1S/C14H14O3/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10/h3-9H,1-2H3,(H,15,16)/t9-/m0/s1</ns4:inchi>
        <ns4:charge>0</ns4:charge>
        <oboInOwl:hasDbXref>Wikipedia:Naproxen</oboInOwl:hasDbXref>
        <ns4:mass>230.25920</ns4:mass>
        <ns4:formula>C14H14O3</ns4:formula>
        <oboInOwl:hasRelatedSynonym>(+)-(S)-Naproxen</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>(+)-(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:9784154</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Patent:US3904682</oboInOwl:hasDbXref>
        <oboInOwl:hasExactSynonym>naproxen</oboInOwl:hasExactSynonym>
        <oboInOwl:hasRelatedSynonym>(S)-Naproxen</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>(+)-2-(6-Methoxy-2-naphthyl)propionic acid</oboInOwl:hasRelatedSynonym>
        <ns4:monoisotopicmass>230.09429</ns4:monoisotopicmass>
        <oboInOwl:hasDbXref>HMDB:HMDB0001923</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>(S)-2-(6-Methoxy-2-naphthyl)propanoic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>(+)-2-(Methoxy-2-naphthyl)-propionic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasAlternativeId>CHEBI:603695</oboInOwl:hasAlternativeId>
        <oboInOwl:hasExactSynonym>(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid</oboInOwl:hasExactSynonym>
        <oboInOwl:hasRelatedSynonym>(+)-2-(Methoxy-2-naphthyl)-propionsaeure</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>(S)-(+)-Naproxen</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>naproxeno</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>PMID:18044350</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>(+)-Naproxen</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>naproxenum</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>(S)-6-Methoxy-alpha-methyl-2-naphthaleneacetic acid</oboInOwl:hasRelatedSynonym>
        <ns2:IAO_0000115>A methoxynaphthalene that is 2-methoxynaphthalene substituted by a carboxy ethyl group at position 6. Naproxen is a non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation  and stiffness caused by conditions such as osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes.</ns2:IAO_0000115>
        <oboInOwl:hasDbXref>LINCS:LSM-5689</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>Drug_Central:1883</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>(S)-2-(6-Methoxy-2-naphthyl)propionic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasRelatedSynonym>naproxen</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>KEGG:D00118</oboInOwl:hasDbXref>
        <oboInOwl:hasDbXref>PMID:24478225</oboInOwl:hasDbXref>
        <oboInOwl:hasRelatedSynonym>naproxene</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasOBONamespace>chebi_ontology</oboInOwl:hasOBONamespace>
        <oboInOwl:hasRelatedSynonym>(S)-(+)-2-(6-Methoxy-2-naphthyl)propionic acid</oboInOwl:hasRelatedSynonym>
        <oboInOwl:hasDbXref>Beilstein:3591067</oboInOwl:hasDbXref>
        <ns4:inchikey>CMWTZPSULFXXJA-VIFPVBQESA-N</ns4:inchikey>
        <oboInOwl:inSubset rdf:resource="http://purl.oboInOwllibrary.org/oboInOwl/chebi#3_STAR"/>
        <ns2:IAO_0000412 rdf:resource="http://purl.obolibrary.org/obo/chebi.owl"/>
    </Class>
</rdf:RDF>



<!-- Generated by the OWL API (version 3.2.4.1806) http://owlapi.sourceforge.net -->



