enzyme Caspase Amino Acid, Peptide, or Protein ICE-like proteases C0010656 Caspases TNF Alpha ICE Proteinases Caspase Cell-Death Protease Caspase Cysteine-Dependent Aspartate-Directed Protease Peptidase Family C14 Enzyme Caspase Caspases are a family of intracellular cysteine proteinases involved in inflammation and apoptosis. These enzymes appear to be involved in the initial signaling events, as well as the downstream proteolytic cleavages, that result in apoptotic cell death. They are specific for aspartic acid at the P1 position and are divided into two classes based on the lengths of their N-terminal pro-domains. Caspases-1, -2, -4, -5, -8, and -10 have long pro-domains; caspases-3, -6, -7, and -9 have short pro-domains. (from Science 1998. 281:1312 and Br Med Bull 1997. 53:478) Caspase ICE-like protease C18153 CTRP Cysteine-aspartic Protease