Neurotrophic Factor Biologically Active Substance Neurotrophic Factor C0132298 Neurotrophin signaling is mediated by the Trk family of receptor tyrosine kinases. (IP, N. Y. (1998), The Neurotrophins and Neuropoietic Cytokines: Two Families of Growth Factors Acting on Neural and Hematopoietic Cells. Annals of the New York Academy of Sciences, 840: 97-106. doi: 10.1111/j.1749-6632.1998.tb09553.x) Neurotrophic_Factor Amino Acid, Peptide, or Protein C20391 Neurotrophic Factor Neurotrophin A family of protein growth factors produced by the nervous system and peripheral target tissues. These proteins are critical for development, growth, regeneration, survival, and differentiation of neurons. protein