antidepressant paroxetine PMID:17652957 KEGG:C07415 PMID:17559097 PMID:16395417 PMID:21908494 0 PMID:14624192 PMID:16397315 PMID:11910269 PMID:19851065 PMID:15853570 LINCS:LSM-2843 PMID:18273418 PMID:14521492 PMID:15845695 Paroxetine PMID:15376524 CHEBI:7936 Wikipedia:Paroxetine PMID:15963219 PMID:14689334 InChI=1S/C19H20FNO3/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18/h1-6,9,14,17,21H,7-8,10-12H2/t14-,17-/m0/s1 PMID:16822276 PMID:18808757 PMID:12906023 PMID:15199661 PMID:17874333 PMID:17286545 PMID:17612590 PMID:15374134 (3S-trans)-3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)piperidine A benzodioxole that consists of piperidine bearing 1,3-benzodioxol-5-yloxy)methyl and 4-fluorophenyl substituents at positions 3 and 4 respectively; the (3S,4R)-diastereomer. Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for alpha1-, alpha2- or beta-adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo. PMID:15048901 PMID:11360029 PMID:22240860 PMID:22263916 Reaxys:7467879 PMID:12818234 CAS:61869-08-7 PMID:11009210 (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine PMID:16913391 PMID:15903129 PMID:17122538 PMID:22198456 PMID:11565622 (-)-(3S,4R)-4-(p-fluorophenyl)-3-((3,4-(methylenedioxy)phenoxy)methyl)piperidine PMID:21739267 PMID:15992089 PMID:12369443 PMID:18983224 PMID:17452166 PMID:21939725 PMID:11563413 PMID:19687003 Drug_Central:2068 PMID:16765127 DrugBank:DB00715 329.36540 PMID:17162096 PMID:11324355 PMID:11513198 PMID:22153922 PMID:15544025 paroxetinum PMID:14566200 PMID:16426087 KEGG:D02362 PMID:12027788 PMID:12920419 PMID:21404089 PMID:22377745 PMID:15613191 PMID:12088162 PMID:14566196 PMID:22283559 PMID:18345955 [H][C@]1(CCNC[C@H]1COc1ccc2OCOc2c1)c1ccc(F)cc1 PMID:14673053 PMID:12820211 PMID:14516531 PMID:11169163 paroxetina C19H20FNO3 PMID:14619895 PMID:21922171 PMID:22353759 PMID:21909633 PMID:21452176 PMID:11271409 PMID:14978354 PMID:12421645 PMID:15264994 PMID:15241233 AHOUBRCZNHFOSL-YOEHRIQHSA-N PMID:17219219 Beilstein:7467879 329.14272 PMID:11281965 PMID:11819027 chebi_ontology PMID:22212003 PMID:11893234