organosulfur compound rofecoxib KEGG:C07590 Vioxx Beilstein:8269007 0 Ceoxx PMID:16934051 PMID:10859630 3-phenyl-4-[4-(methylsulfonyl)phenyl]-2(5H)-furanone DrugBank:DB00533 rofecoxibum LINCS:LSM-2482 PMID:28166217 4-[4-(methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone C17H14O4S Reaxys:8269007 4-[4-(methylsulfonyl)phenyl]-3-phenylfuran-2(5H)-one Drug_Central:2397 InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3 CAS:162011-90-7 chebi_ontology CS(=O)(=O)c1ccc(cc1)C1=C(C(=O)OC1)c1ccccc1 KEGG:D00568 PMID:20162413 RZJQGNCSTQAWON-UHFFFAOYSA-N Wikipedia:Rofecoxib rofecoxib CHEBI:8887 314.06128 PMID:12069696 314.35600 Rofecoxib A butenolide that is furan-2(5H)-one substituted by a phenyl group at position 3 and by a p-(methylsulfonyl)phenyl group at position 4. A selective cyclooxygenase 2 inhibitor, it was used from 1999 to 2004 for the treatment of ostoarthritis, but was withdrawn following concerns about an associated increased risk of heart attack and stroke. PMID:11014111