involves is about angioedema finding 20130423, MC: in the anaphylaxis case definition, angioedeme can be localized or generalized. There was no need as of today to create specialized subclasses representing those. AngEdGenLoc Areas of deeper swelling of the skin and/or mucosal tissues in either single or multiple sites which may not be well circumscribed and is usually not itchy. Reported symptoms of ‘swelling of the lip’ or ‘swelling of the tongue or throat’ should not be documented as angioedema unless there is visible skin or mucosal swelling. Vaccine 28 (2010) 4487-4498 generalized pruritus with skin rash finding major cardiovascular criterion for anaphylaxis according to Brighton major respiratory criterion for anaphylaxis according to Brighton measured hypotension finding uncompensated shock sign finding tachycardia finding capillary refill time > 3s finding reduced central pulse volume finding stridor finding upper airway swelling finding tachypnoea finding increased use of accessory respiratory muscles finding recession finding cyanosis finding grunting finding respiratory distress sign finding reduced peripheral circulation finding generalized pruritus without skin rash finding hoarse voice finding sensation of throat closure finding diarrhoea finding abdominal pain finding nausea finding vomiting finding mast cell tryptase elevation > upper normal limit finding gastrointestinal sign dry cough finding chest tightness finding indrawing finding rhinorrhea finding sore throat finding wheezing finding erythema finding red eyes finding itchy eyes finding prickle sensation finding pruritus finding rash finding urticaria finding decreased level of consciousness finding sneezing finding difficulty breathing finding diagnosis textual entity clinical finding dermatological-mucosal system angioedema