negatively regulates biological regulation protein localization to cell leading edge negative regulation of protein localization regulation of protein localization to cell leading edge negative regulation of protein localization to cell leading edge down-regulation of protein localisation to cell leading edge Any process that stops, prevents or reduces the frequency, rate or extent of protein localization to cell leading edge. down-regulation of protein localization to cell leading edge down-regulation of protein localization in cell leading edge downregulation of protein localisation to cell leading edge down regulation of protein localization in cell leading edge down regulation of protein localisation in cell leading edge downregulation of protein localization to cell leading edge down-regulation of protein localisation in cell leading edge downregulation of protein localisation in cell leading edge negative regulation of protein localization in cell leading edge down regulation of protein localization to cell leading edge down regulation of protein localisation to cell leading edge 2017-01-27T19:35:04Z negative regulation of protein localisation in cell leading edge downregulation of protein localization in cell leading edge negative regulation of protein localisation to cell leading edge GO:1905872 biological_process