cefoxitin Mefoxitin antibiotic_resistance CAS:35607-66-0 Cefoxitin is a cephamycin antibiotic often grouped with the second generation cephalosporins. Cefoxitin is bactericidal and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. Cefoxitin's 7-alpha-methoxy group and 3' leaving group make it a poor substrate for most beta-lactamases. ChEMBL:CHEMBL996 FOX mefoxin PubChem:441199 ChEBI:209807 ARO:0000008 second-generation cephalosporin