fosfomycin ChEBI:28915 PubChem:73491 CAS:23155-02-4 (1R,2S)-1,2-epoxy-propylphosphonic acid phosphonomycin antibiotic_resistance ARO:0000025 ChEMBL:CHEMBL1757 phosphomycin Fosfomycin (also known as phosphomycin and phosphonomycin) is a broad-spectrum antibiotic produced by certain Streptomyces species. It is effective on gram positive and negative bacteria as it targets the cell wall, an essential feature shared by both bacteria. Its specific target is MurA (MurZ in E.coli), which attaches phosphoenolpyruvate (PEP) to UDP-N-acetylglucosamine, a step of commitment to cell wall synthesis. In the active site of MurA, the active cysteine molecule is alkylated which stops the catalytic reaction. phosphonic acid antibiotic