cefepime antibiotic_resistance ARO:0000059 Axepim Cefepime (INN) is a fourth-generation cephalosporin antibiotic developed in 1994. It contains an aminothiazolyl group that decreases its affinity with beta-lactamases. Cefepime shows high binding affinity with penicillin-binding proteins and has an extended spectrum of activity against Gram-positive and Gram-negative bacteria, with greater activity against both Gram-negative and Gram-positive organisms than third-generation agents. Cefepimum PubChem:5479537 Cefepima FEP Maxipime ChEMBL:CHEMBL186 ChEBI:478164 CAS:88040-23-7 fourth-generation cephalosporin