resistance-nodulation-cell division (RND) antibiotic efflux pump antibiotic_resistance ARO:0010004 RND type drug efflux Directed pumping of antibiotic out of a cell to confer resistance. Resistance-nodulation-division (RND) proteins are found in both prokaryotic and eukaryotic cells and have diverse substrate specificities and physiological roles. However, there are relatively few RND transporters and they are secondary transporters, energized not by ATP binding/hydrolysis but by proton movement down the transmembrane electrochemical gradient. efflux pump complex or subunit conferring antibiotic resistance