confers_resistance_to_drug_class carbapenem cephalosporin confers_resistance_to_drug_class penicillin beta-lactam VIM beta-lactamase antibiotic_resistance ARO:3000021 The Verone integron-encoded metallo-beta-lactamase (VIM) family was reported from Italy in 1999. There are, to date, 23 reported variants. VIM enzymes mostly occur in P. aeruginosa, also P. putida and, very rarely, Enterobacteriaceae. Integron-associated, sometimes within plasmids. Hydrolyses all beta-lactams except monobactams, and evades all beta-lactam inhibitors. There is a strong incidence of these in East Asia. subclass B1 (metallo-) beta-lactamase