confers_resistance_to_drug_class monobactam carbapenem cephalosporin confers_resistance_to_drug_class penicillin beta-lactam KPC beta-lactamase Klebsiella pneumoniae carbapenem resistant (KPC) beta-lactamases are notorious for their ability to efficiently hydrolyze carbapenems, unlike other Ambler Class A beta-lactamases. There are currently 9 variants reported worldwide. These enzymes were first isolated from Klebsiella pneumoniae strains in 2001 in the United States. Hospital outbreaks have since been reported in Greece and Israel and KPC carrying strains are now endemic to New York facilities. KPC-1 and KPC-2 have been shown to be identical and are now referred to as KPC-2. ARO:3000059 antibiotic_resistance class A beta-lactamase