<?xml version="1.0"?>
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    <AnnotationProperty rdf:about="http://purl.obolibrary.org/obo/IAO_0000115"/>
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    <!-- http://purl.obolibrary.org/obo/ARO_3000053 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/ARO_3000053">
        <rdfs:label>peptide antibiotic</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/ARO_3000119 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/ARO_3000119">
        <rdfs:label>edeine</rdfs:label>
    </Class>
    


    <!-- http://purl.obolibrary.org/obo/ARO_3000134 -->

    <Class rdf:about="http://purl.obolibrary.org/obo/ARO_3000134">
        <rdfs:label>edeine B</rdfs:label>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/ARO_3000053"/>
        <rdfs:subClassOf rdf:resource="http://purl.obolibrary.org/obo/ARO_3000119"/>
        <oboInOwl:hasDbXref>PubChem:446232</oboInOwl:hasDbXref>
        <ns3:IAO_0000115>Edeine B is a subtype of the peptide antibiotic edeine, composed of beta-tyr, beta-ser, diaminopropionic acid, diaminohydroxyazelaic acid, glycine, and guanylspermidine. Edeine B is a mixture of edeine B1 and its inactive isomer, edeine B2.  Edeines bind to the 30S subunit to block fMet-tRNA interaction at the P site, inhibiting protein synthesis and subsequent structure/function processes critical for life or replication. Edeine B has also been shown to inhibit septation and cause filamentous morphology, also leading to cell death.</ns3:IAO_0000115>
        <oboInOwl:id>ARO:3000134</oboInOwl:id>
        <oboInOwl:hasOBONamespace>antibiotic_resistance</oboInOwl:hasOBONamespace>
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