confers_resistance_to_drug_class lincosamide antibiotic streptogramin antibiotic confers_resistance_to_drug_class oxazolidinone antibiotic Cfr 23S ribosomal RNA methyltransferase ARO:3000202 Cfr genes produce enzymes which catalyze the methylation of the 23S rRNA subunit at position 8 of adenine-2503. Methylation of 23S rRNA at this site confers resistance to some classes of antibiotics, including streptogramins, chloramphenicols, florfenicols, linezolids and clindamycin. antibiotic_resistance phenicol antibiotic S-adenosylmethionine (SAM) superfamily