confers_resistance_to_drug_class derives_from confers_resistance_to_drug_class rifamycin antibiotic rifamycin-resistant beta-subunit of RNA polymerase (rpoB) antibiotic_resistance ARO:3000210 Rifampin resistant RNA polymerases include amino acids substitutions which disrupt the affinity of rifampin for its binding site. These mutations are frequently concentrated in the rif I region of the beta-subunit and most often involve amino acids which make direct interactions with rifampin. However, mutations which also confer resistance can occur outside this region and may involve amino acids which do not directly make contact with rifampin. antibiotic target replacement protein rifamycin sensitive beta-subunit of RNA polymerase (rpoB) antibiotic resistant rpoB