confers_resistance_to_antibiotic erythromycin roxithromycin lincomycin telithromycin clarithromycin clindamycin confers_resistance_to_antibiotic tylosin spiramycin azithromycin dirithromycin ErmC ErmC' ermIM ARO:3000250 antibiotic_resistance ErmC ErmC is a methyltransferase that catalyzes the methylation of A2058 of the 23S ribosomal RNA in two steps. Expression of ErmC is inducible by erythromycin. The leader peptide causes attenuation of the mRNA and stabilizes the structure preventing further translation. When erythromycin is present, it binds the leader peptide causing a change in conformation allowing for the expression of ErmC. ermM Erm 23S ribosomal RNA methyltransferase pristinamycin IA quinupristin virginiamycin M1 madumycin II griseoviridin dalfopristin pristinamycin IB virginiamycin S2 pristinamycin IC vernamycin C patricin A patricin B ostreogrycin B3 oleandomycin