confers_resistance_to_antibiotic vancomycin confers_resistance_to_antibiotic glycopeptide resistance gene cluster glycopeptide resistance gene cluster VanL vanL_cluster antibiotic_resistance ARO:3000260 Homologous to VanC, contains a D-Ala-D-Ser ligase. The chromosome-located vanL gene cluster is inducible and confers low resistance to vancomycin. vanL organisms remain susceptible to teicoplanin. It is the only van gene cluster with two vanT genes. Gene orientation: vanL(XY)TmTrRS.