derives_from rRNA with mutation conferring antibiotic resistance 23S rRNA with mutation conferring antibiotic resistance antibiotic_resistance Point mutations in bacterial 23S rRNA from the large ribosomal subunit that confer resistance to antibiotics. Antibiotics such as linezolid block peptide synthesis through peptidyl transferase activity. Mutations in the 23S rRNA subunit reduce antibiotic binding affinity at specific sites, conferring resistance. ARO:3000336 antibiotic sensitive peptidyl transferase (23S rRNA)