confers_resistance_to_drug_class derives_from confers_resistance_to_drug_class aminocoumarin sensitive parE aminocoumarin antibiotic antibiotic resistant DNA topoisomerase subunit parE aminocoumarin resistant parE ARO:3000457 ParE is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Point mutations in ParE prevent anticoumarin antibiotics from inhibiting DNA synthesis, thus conferring resistance. antibiotic_resistance