confers_resistance_to_antibiotic confers_resistance_to_antibiotic tylosin gimA gimA ARO:3000463 antibiotic_resistance A macrolide glycosyltransferase encoded by the gimA gene in Streptomyces ambofaciens, a natural producer of the macrolide antibiotic spiramycin. Chalcomycin, methymycin, tylosin, pikromycin, rosaramicin, oleandomycin, josamycin, and carbomycin are preferred substrates of gimA glycosyltransferase, while erythromycin and spiramycin have notably low binding affinities. GimA may be able to inactivate spiramycin precursors. Described by Gourmelen et al. 1998. oleandomycin chalcomycin methymycin gimA family macrolide glycosyltransferase