confers_resistance_to_drug_class macrolide antibiotic lincosamide antibiotic streptogramin antibiotic confers_resistance_to_drug_class Erm 23S ribosomal RNA methyltransferase Erm proteins are part of the RNA methyltransferase family and methylate A2058 (E. coli nomenclature) of the 23S ribosomal RNA conferring degrees of resistance to Macrolides, Lincosamides and Streptogramin b. This is called the MLSb phenotype. antibiotic_resistance ARO:3000560 23S ribosomal RNA methyltransferase