confers_resistance_to_drug_class macrolide antibiotic lincosamide antibiotic streptogramin antibiotic confers_resistance_to_drug_class Erm-like 23S rRNA methyltransferase antibiotic_resistance Erm proteins are part of the RNA methyltransferase family and methylate A2058 (E. coli numbering) of the 23S ribosomal RNA conferring degrees of resistance to Macrolides, Lincosamides and Streptogramin. This is called the MLS phenotype. ARO:3000560 23S rRNA (adenine(2058)-N(6))-methyltransferase