confers_resistance_to_antibiotic erythromycin roxithromycin lincomycin telithromycin clarithromycin clindamycin confers_resistance_to_antibiotic tylosin spiramycin azithromycin dirithromycin Erm 23S ribosomal RNA methyltransferase pristinamycin IA quinupristin ErmN ErmN ARO:3000592 antibiotic_resistance ErmN is a methyltransferase found in the tylosin producer Streptomyces fradiae. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers only one methyl group. The gene is found in the tylosin biosynthetic cluster and is responsible for self-resistance to tylosin. tlrD virginiamycin M1 madumycin II griseoviridin dalfopristin pristinamycin IB virginiamycin S2 pristinamycin IC vernamycin C patricin A patricin B ostreogrycin B3 oleandomycin