confers_resistance_to_drug_class derives_from fluoroquinolone antibiotic confers_resistance_to_drug_class antibiotic resistant DNA topoisomerase subunit parC fluoroquinolone resistant DNA topoisomerase fluoroquinolone resistant parC ARO:3000619 antibiotic_resistance ParC is a subunit of topoisomerase IV, which decatenates and relaxes DNA to allow access to genes for transcription or translation. Point mutations in ParC prevent fluoroquinolone antibiotics from inhibiting DNA synthesis, and confer low-level resistance. Higher-level resistance results from both gyrA and parC mutations. Fluoroquinolone sensitive parC