targeted_by targeted_by_antibiotic polymyxin antibiotic targeted_by targeted_by_antibiotic gramicidin gramicidin S gramicidin A gramicidin B gramicidin C colistin A colistin B polymyxin B1 polymyxin B2 polymyxin B3 polymyxin B4 defensin magainin antibiotic target cell membrane component targeted by antibiotic antibiotic_resistance Interaction with the cell membrane phospholipids interferes with membrane permeability and integrity, leading to the leakage of cell contents. The outer membrane of Gram-negative bacteria is particularly sensitive. ARO:3000710