targeted_by targeted_by_antibiotic targeted_by targeted_by_antibiotic sulfonamide antibiotic sulfadiazine sulfadimidine sulfadoxine sulfamethoxazole sulfisoxazole sulfacetamide mafenide sulfasalazine sulfamethizole folate synthesis enzyme targeted by antibiotic antibiotic sensitive dihydropteroate synthase Dihydropteroate synthase catalyzes the conversion of p-aminobenzoic acid to dihydropteroic acid as part of the tetrahydrofolic acid biosynthetic pathway. Tetrahydrofolic acid is essential for folate synthesis, and a precursor of many nucleotides and amino acids. Inhibiting dihydropteroate leads to slow cell death, as bacteria can survive on existing folate storages for a few generations. ARO:3000744 antibiotic_resistance sulfone antibiotic dapsone