targeted_by targeted_by_antibiotic cefoxitin cloxacillin methicillin carbenicillin oxacillin cefazolin cefepime ceftazidime ceftobiprole ceftriaxone cefuroxime amoxicillin ertapenem meropenem piperacillin targeted_by targeted_by_antibiotic beta-lactam antibiotic imipenem aztreonam benzylpenicillin phenoxymethylpenicillin propicillin dicloxacillin flucloxacillin ampicillin azlocillin mezlocillin doripenem cefalexin cefadroxil cefotiam cefaclor cefotaxime cefixime cefpodoxime ceftibuten cefditoren cefdinir ceftaroline cefalotin cell wall synthesis enzyme targeted by antibiotic beta-lactam sensitive penicillin-binding protein ARO:3000749 antibiotic_resistance Penicillin-binding proteins (PBPs) are responsible for transpeptidation, joining subunits to form peptidoglycan. They are numbered according to descending molecular weight, and may vary between species. These numbers represent the PBPs of E. coli. Inhibition of the larger PBPs responsible for transpeptidation (1-3) are lethal. Smaller PBPs (4-6) are involed in carboxypeptidation; inhibition of these is non-lethal. mecillinam cefmetazole cefonicid cefprozil ceftiofur ceftizoxime cephapirin cefradine loracarbef moxalactam