confers_resistance_to_drug_class regulates confers_resistance_to_drug_class peptide antibiotic protein(s) and two-component regulatory system modulating antibiotic efflux MacAB-TolC phoPQ ARO:3000821 PhoPQ is a two-component regulatory system. phoP is phosphorylated by phoQ at a low [mg2+], activating the repressor. Its part of a two component regulating system that activates the PmrA/B system which has downstream effects, leading to Antimicrobial resistance in many pathogens. In Salmonella, phoP bind to macAB ABC transporter and represses it. In Escherichia coli, phoPQ regulates arnA expression. In Pseudomonas aeruginosa, phoPQ regulates OprH expression. phoPQ have other roles in other species. antibiotic_resistance PhoP/Q arnA basRS mgrB