confers_resistance_to_antibiotic lincomycin confers_resistance_to_antibiotic spiramycin Erm 23S ribosomal RNA methyltransferase carbomycin ErmO-srmA ErmO-srmA ARO:3001303 antibiotic_resistance srmA ErmO (gene srmA) is a methyltransferase found in the spiramycin producer Streptomyces ambofaciens. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers only one methyl group. The gene is responsible for self-resistance to spiramycin.