confers_resistance_to_antibiotic lincomycin confers_resistance_to_antibiotic tylosin Erm 23S ribosomal RNA methyltransferase pristinamycin IC carbomycin niddamycin ErmS ErmS is a methyltransferase found in the tylosin producer Streptomyces fradiae. Like other Erm enzymes, it catalyzes the methylation of A2058 of the 23S ribosomal RNA. Specifically, this enzyme transfers two methyl groups. The gene is found within the tylosin biosynthetic cluster and is responsible for self-resistance. antibiotic_resistance ErmS ermSF tlrA ARO:3001304