pleuromutilin antibiotic pleuromutilin Pleuromutilin is a natural product antibiotic produced by Clitopilus passeckerianus. Related antibiotics of clinical significance, such as tiamulin and retapamulin, are semi-synthetic derivatives of this compound. ChEMBL:CHEMBL3989485 ARO:3001317 CAS:125-65-5 ChEBI:8269 PubChem:31326 antibiotic_resistance