confers_resistance_to_antibiotic fosfomycin confers_resistance_to_antibiotic fosfomycin thiol transferase FosA3 FosA3 ARO:3002872 antibiotic_resistance An enzyme that confers resistance to fosfomycin in Escherichia coli by breaking the epoxide ring of the molecule. It depends on the cofactors Manganese (II) and Potassium and uses Glutathione (GSH) as the nucleophilic molecule.